WorldWideScience

Sample records for central japan response

  1. Central bank capital, financial strength, and the Bank of Japan

    OpenAIRE

    Thomas F. Cargill

    2006-01-01

    This Economic Letter addresses central bank capital and financial strength in the context of Bank of Japan policy (Cargill 2005). Specifically, it reviews general considerations about central bank capital and financial strength, discusses recent Bank of Japan policy in the context of capital structure, evaluates the Bank of Japan's concern in the context of the broader issue of central bank independence, and draws some lessons from recent Bank of Japan policy.

  2. NATION BRANDING THROUGH STIGMATIZED POPULAR CULTURE: THE "COOL JAPAN" CRAZE AMONG CENTRAL MINISTRIES IN JAPAN

    OpenAIRE

    Matsui, Takeshi

    2014-01-01

    This paper investigates how and why various central ministries in Japan have adopted policies promoting Japanese popular culture such as manga (comic books), anime (animated films and TV shows), games, fashion and so forth, which had formerly been neglected by the state due to their stigmatized status. This paper analyzes documents released by bureaucrats and the results of interviews conducted with key persons from central ministries and institutions under their jurisdiction to shed light on...

  3. Japan.

    Science.gov (United States)

    1989-02-01

    Japan consists of 3900 islands and lies off the east coast of Asia. Even though Japan is one of the most densely populated nations in the world, its growth rate has stabilized at .5%. 94% of all children go to senior high school and almost 90% finish. Responsibility for the sick, aged, and infirmed is changing from the family and private sector to government. Japan was founded in 600 BC and its 1st capital was in Nara (710-1867). The Portuguese, the 1st Westerners to make contact with Japan in 1542, opened trade which lasted until the mid 17th century. US Navy Commodore Matthew Perry forced Japan to reopen in 1854. Following wars with China and Russia in the late 1800s and early 1900s respectively, Japan took part in World Wars I and II. In between these wars Japan invaded Manchuria and China. The US dropped an atomic bomb on Hiroshima and Nagasaki and the Japanese surrendered in September, 1945 ending World War II (WWII). Following, WWII, the Allied Powers guided Japan's establishment as a nonthreatening nation and a democratic parliamentary government (a constitutional monarchy) with a limited defense force. Japan remains one of the most politically stable of all postwar democracies. The Liberal Democratic Party's Noboru Takeshita became prime minister in 1987. Japan has limited natural resources and only 19% of the land is arable. Japanese ingenuity and skill combine to produce one of the highest per hectare crop yields in the world. Japan is a major economic power, and its and the US economies are becoming more interdependent. Its exports, making up only 13% of the gross national product, mainly go to Canada and the US. Many in the US are concerned, however, with the trade deficit with Japan and are seeking ways to make trade more equitable. Japan wishes to maintain good relations with its Asian neighbors and other nations. The US and Japan enjoy a strong, productive relationship.

  4. Broadband hydroseismograms observed by closed borehole wells in the Kamioka mine, central Japan: Response of pore pressure to seismic waves from 0.05 to 2 Hz

    Science.gov (United States)

    Kano, Yasuyuki; Yanagidani, Takashi

    2006-03-01

    We obtained broadband hydroseismograms by monitoring the pore pressure changes of a rock mass in the Kamioka mine, using borehole wells. The wellhead was sealed to maintain an undrained condition, under which there is no flow of water through the interface between the well and the rock mass. This reduces the wellbore storage effect, which can cause a high-frequency cutoff response for systems of conventional open wells and rock mass. Using these closed borehole wells, 16 hydroseismograms were recorded for earthquakes in a range of magnitudes of 4.5-7.9 and epicentral distances of 1.0°-71.6°. Direct P waves, SV waves converted to P, and Rayleigh phases are clearly observed on the hydroseismograms. The similarity between hydroseismograms and seismograms reveals a clear relationship between radial ground velocity and pore pressure. The relationship is expressed as a zero-order system, which is characterized by no distortion or time lag between the input and output, and the pore pressure has no coupling with shear deformation. These results are consistent with an undrained constitutive relation of linear poroelastic theory and confirm that the relation is valid for the seismic frequency range. We determined in situ values of pore pressure sensitivity to volumetric change of the rock mass, which were then used to estimate in situ Skempton coefficients with values of 0.70-0.85.

  5. Nitrous oxide fluxes from upland soils in central Hokkaido, Japan

    Institute of Scientific and Technical Information of China (English)

    MU Zhijian; Sonoko D. KIMURA; Yo TOMA; Ryusuke HATANO

    2008-01-01

    Nitrous oxide (N2O) fluxes from soils were measured using the closed chamber method during the snow-free seasons (middle April to early November), for three years, in a total of 11 upland crop fields in central Hokkaido, Japan. The annual mean N2O fluxes ranged fluxes showed a large temporal variation with peak emissions generally occurring following fertilization and heavy rainfall events around harvesting in autumn. No clear common factor regulating instantaneous N2O fluxes was found at any of the study sites. Instead,instantaneous N2O fluxes at different sites were affected by different soil variables. The cumulative N2O emissions during the study period within each year varied from 0.15 to 7.05 kgN/hm2 for different sites, which accounted for 0.33% to 5.09% of the applied fertilizer N. No obvious relationship was observed between cumulative N2O emission and applied fertilizer N rate (P>0.4). However,the cumulative N2O emission was significantly correlated with gross mineralized N as estimated by CO2 emissions from bare soils divided by C/N ratios of each soil, and with soil mineral N pool (I.e., the sum of gross mineralized N and fertilizer N) (P<0.001).

  6. The stock market performance of the central banks of Belgium and Japan

    NARCIS (Netherlands)

    Goldberg, Lawrence G.; Kabir, Rezaul

    2002-01-01

    Most central banks issue stock that is held by the government and/or commercial banks and is not tradable. In contrast, stocks of the central banks of Belgium and Japan are traded on the Brussels and Tokyo stock exchanges. The purpose of the paper is to examine this unique phenomenon of stock market

  7. The stock market performance of the central banks of Belgium and Japan

    NARCIS (Netherlands)

    Kabir, Mohammed Rezaul; Goldberg, Lawrence G.

    2002-01-01

    Most central banks issue stock that is held by the government and/or commercial banks and is not tradable. In contrast, stocks of the central banks of Belgium and Japan are traded on the Brussels and Tokyo stock exchanges. The purpose of the paper is to examine this unique phenomenon of stock market

  8. FORMATIVE MECHANISM OF AKAISHI MOUNTAINS AND ENREI BASIN IN CENTRAL JAPAN

    Institute of Scientific and Technical Information of China (English)

    Yasu'uchi KUBOTA; Takao YANO

    2001-01-01

    @@ 1 Introduction It is common in mobile belts that uplifting mountains are neighbored by synchronously subsiding basins.The coupling mechanism of such subsidence and uplift is an important target to clarify the dynamics of mobile belts.We investigate the coupled mountain uplift and basin subsidence in the Central Japan highland,the junction of three island arcs (the Northeast Japan,the Southwest Japan and the Izu-Ogasawara arcs).The highland over 3 000 m in height is composed of mountain ranges,plateaus and intramountain basins (Fig.1).

  9. FORMATIVE MECHANISM OF AKAISHI MOUNTAINS AND ENREI BASIN IN CENTRAL JAPAN

    Institute of Scientific and Technical Information of China (English)

    Yasu'uchi; KUBOTA; Takao; YANO

    2001-01-01

    1 Introduction  It is common in mobile belts that uplifting mountains are neighbored by synchronously subsiding basins.The coupling mechanism of such subsidence and uplift is an important target to clarify the dynamics of mobile belts.We investigate the coupled mountain uplift and basin subsidence in the Central Japan highland,the junction of three island arcs (the Northeast Japan,the Southwest Japan and the Izu-Ogasawara arcs).The highland over 3 000 m in height is composed of mountain ranges,plateaus and intramountain basins (Fig.1).……

  10. Kosa (yellow sand) components in precipitation collected at central Japan

    Institute of Scientific and Technical Information of China (English)

    Chohji; Tetsuji; Kitamura; Moritsugu; Tabata; Masahiro

    2002-01-01

    In east Asia, acidic gases derived from fossil fuel combustion have increased in the pastdecades. On the other hand, the Asian dust, also called Kosa (yellow sand) is transported follow-ing windstorms from arid lands in the Asian continent. Many researchers have been interested inthe reaction between acidic aerosols and Kosa aerosols as well as the long-range transport ofthese emissions. To investigate the characteristics of chemical components in precipitation on along-term basis over Japan, precipitation was sequentially collected from April 1984 to March 1997at Kanazawa located near the coast of the Sea of Japan. Precipitation samples were collected at 1mm intervals for the first 5 mm rainfall and all volume of rainwater after 6 mm for all precipitationevents with an automatic wet only precipitation collector. According to the analyses of precipitationincluding Kosa aerosols during Kosa periods, the reaction in the air between Kosa and acidiccomponents during the long-range transport was discussed.

  11. Japan.

    Science.gov (United States)

    1987-02-01

    Japan is composed of 4 main islands and more than 3900 smaller islands and has 317.7 persons/square kilometer. This makes it one of the most densely populated nations in the world. Religion is an important force in the life of the Japanese and most consider themselves Buddhists. Schooling is free through junior high but 90% of Japanese students complete high school. In fact, Japan enjoys one of the highest literacy rates in the world. There are over 178 newspapers and 3500 magazines published in Japan and the number of new book titles issued each year is greater than that in the US. Since WW1, Japan expanded its influence in Asia and its holdings in the Pacific. However, as a direct result of WW2, Japan lost all of its overseas possessions and was able to retain only its own islands. Since 1952, Japan has been ruled by conservative governments which cooperate closely with the West. Great economic growth has come since the post-treaty period. Japan as a constitutional monarchy operates within the framework of a constitution which became effective in May 1947. Executive power is vested in a cabinet which includes the prime minister and the ministers of state. Japan is one of the most politically stable of the postwar democracies and the Liberal Democratic Party is representative of Japanese moderate conservatism. The economy of Japan is strong and growing. With few resources, there is only 19% of Japanese land suitable for cultivation. Its exports earn only about 19% of the country's gross national product. More than 59 million workers comprise Japan's labor force, 40% of whom are women. Japan and the US are strongly linked trading partners and after Canada, Japan is the largest trading partner of the US. Foreign policy since 1952 has fostered close cooperation with the West and Japan is vitally interested in good relations with its neighbors. Relations with the Soviet Union are not close although Japan is attempting to improve the situation. US policy is based on

  12. [Distribution of Clostridium tetani in topsoil from Sagamihara, central Japan].

    Science.gov (United States)

    Haneda, Jun; Shiobara, Yasumasa; Inui, Masami; Sekiguchi, Tomoko; Sato, Yoshinori; Takayama, Yoko; Kikuno, Ritsuko; Okuda, Shunji; Inoue, Matsuhisa; Sasahara, Takeshi

    2006-11-01

    Despite reports of Clostridium tetani being isolated from soil in Kanazawa, Okinawa, and Tokyo, Japan, little has been studied about C. tetani distribution in other regions. We studied C. tetani in topsoil samples collected from private gardens, public road shoulders, a university campus, mountains, and fields in Sagamihara. C. tetani occurred in 8 of 35 soil samples (22.9%) and tetanus toxin in 7 of the 8 C. tetani-positive samples (87.5%). Contamination was clearly higher in soils from mountains near Tsukui-gun (Kanagawa Prefecture), Minamitsuru-gun, and Uenohara and Koshu cities (Yamanashi Prefecture) than in other regions. These findings suggest that tetanus toxin-producing strains of C. tetani tend to inhabit the topsoil of western Sagaminaha region, as a geographical feature.

  13. Japan

    Science.gov (United States)

    Hawkins, John N.

    1986-01-01

    Analyzes the intergroup relations in Japanese society and Japan's educational system. Challenges the view that Japan is a homogeneous society by presenting the various forms of discrimination against Koreans, Ainu, and the burakumin. Suggests that despite ostracism and isolation, groups can affect public policy and achieve social advancement. (SA)

  14. Japan

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    2013-01-01

    I 1500- og 1600-tallet dannedes tidligt moderne stater i Europa, men samtidig eksisterede der ligeså avancerede statsdannelser uden for Europa, bl.a. i Kina, Indien og Japan. I det følgende ser vi nærmere på dannelsen af den moderne stat i Japan. Hvorfor blev Japan aldrig en europæisk koloni......? Hvordan havde japanske magthavere igennem 300 år forberedt Japan og de mennesker, der boede på de japanske øer, til at kunne udvikle en nation, der skulle blive den stærkeste og rigeste i Asien i mere end 100 år? Hvem bestemte i Japan? Kejseren eller shogunen?...

  15. Japan

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    2013-01-01

    I 1500- og 1600-tallet dannedes tidligt moderne stater i Europa, men samtidig eksisterede der ligeså avancerede statsdannelser uden for Europa, bl.a. i Kina, Indien og Japan. I det følgende ser vi nærmere på dannelsen af den moderne stat i Japan. Hvorfor blev Japan aldrig en europæisk koloni......? Hvordan havde japanske magthavere igennem 300 år forberedt Japan og de mennesker, der boede på de japanske øer, til at kunne udvikle en nation, der skulle blive den stærkeste og rigeste i Asien i mere end 100 år? Hvem bestemte i Japan? Kejseren eller shogunen?...

  16. Learning from Japan: strengthening US emergency care and disaster response.

    Science.gov (United States)

    Parmar, Parveen; Arii, Maya; Kayden, Stephanie

    2013-12-01

    As Hurricane Katrina demonstrated in 2005, US health response systems for disasters-typically designed to handle only short-term mass-casualty events-are inadequately prepared for disasters that result in large-scale population displacements. Similarly, after the 2011 Great East Japan Earthquake, Japan found that many of its disaster shelters failed to meet international standards for long-term provision of basic needs and health care for the vulnerable populations that sought refuge in the shelters. Hospital disaster plans had not been tested and turned out to be inadequate, and emergency communication equipment did not function. We make policy recommendations that aim to improve US responses to mass-displacement disasters based on Japan's 2011 experience. First, response systems must provide for the extended care of large populations of chronically ill and vulnerable people. Second, policies should ensure that shelters meet or exceed international standards for the provision of food, water, sanitation, and privacy. Third, hospital disaster plans should include redundant communication systems and sufficient emergency provisions for both staff and patients. Finally, there must be routine drills for responses to mass-displacement disasters so that areas needing improvement can be uncovered before an emergency occurs.

  17. Japan

    OpenAIRE

    Kazujo Suzuki

    2000-01-01

    This contribution aims to introduce the situation of qualitative research in social science in Japan, with an emphasis on qualitative research in psychology. At first, the history of psychology in Japan is briefly discussed and qualitative research in the history of the Japanese psychology is described. Then trends and problems of qualitative research in present-day psychology are mentioned. Finally, qualitative research in the other social sciences are briefly touched on. URN: urn:nbn:de:...

  18. Persistent Aseismic Deformation in Central Japan Revealed by GPS Observation Before and After the 2011 Tohoku-Oki Earthquake

    Science.gov (United States)

    Meneses Gutierrez, A. D. V.; Sagiya, T.

    2015-12-01

    On March 11th, 2011 the occurrence of the Tohoku-oki Earthquake (Mw 9.0) considerably changed the observed crustal deformation pattern in Central -Eastern Japan, providing the opportunity to study the mechanical properties in the area, since elastic and inelastic mediums would have different response to the coseismic instantaneous displacement as well as transient postseismic displacement. In the near field of the 2011 Tohoku-oki earthquake, it is difficult to extract a pure deformation response since direct effects from the postseismic deformation source are mixed. In order to focus on the response at the far field, we analyzed postseismic crustal deformation in Central Japan. Before the quake, we observe general East-West contraction with localize deformation in the eastern margin of the Japan Sea, known as the Niigata Kobe Tectonic Zone (NKTZ) (Sagiya, 2000), whereas the coseismic response, which corresponds to the instantaneous elastic strain release, do not indicate highly concentrated strain feature, as expected if the deformation could be explain only by an elastic behavior. This implies that the interseismic and coseismic strains are not balanced and there is significant amount of contribution of inelastic processes. In the Earth's crust, inelastic processes are expected to take a form of aseismic faulting, and should be distinguished from elastic behavior by its spatial wavelength. Also, the inelastic behavior can be persistent before and after the quake since the coseismic stress change in the far field is considered to be too small to change the regional stress that drives the inelastic process. Thus we review temporal variation of crustal deformation pattern in Central Japan based on daily coordinates of 837 GPS sites from GEONET, before and after the Tohoku-oki earthquake in order to distinguish elastic and inelastic behavior within the NKTZ. We found that the deformation in the area can be explained as a combination of two processes: an elastic

  19. Japan

    OpenAIRE

    World Bank Group

    2016-01-01

    This economy profile presents the Doing Business indicators for Japan. To allow useful comparison, it also provides data for other selected economies (comparator economies) for each indicator. Doing Business 2017 is the 14th in a series of annual reports investigating the regulations that enhance business activity and those that constrain it. Economies are ranked on their ease of doing bus...

  20. Application of InSAR and GIS techniques to ground subsidence assessment in the Nobi Plain, Central Japan

    National Research Council Canada - National Science Library

    Zheng, Minxue; Fukuyama, Kaoru; Sanga-Ngoie, Kazadi

    Spatial variation and temporal changes in ground subsidence over the Nobi Plain, Central Japan, are assessed using GIS techniques and ground level measurements data taken over this area since the 1970s...

  1. Decoupling of Pacific subduction zone guided waves beneath central Japan: Evidence for thin slab

    Science.gov (United States)

    Padhy, Simanchal; Furumura, Takashi; Maeda, Takuto

    2014-11-01

    The fine-scale seismic structure of the northeast Japan subduction zone is studied based on waveform analyses of moderate-sized (M4.5-6), deep-focus earthquakes (h >350 km) and the finite difference method (FDM) simulation of high-frequency (up to 8 Hz) wave propagation. Strong regional S wave attenuation anomalies for specific source-receiver paths connecting the cluster of events occurring in central part of the Sea of Japan recorded at fore arc stations in northern and central Japanese Islands (Honshu) are used to model the deeper structure of the subducting Pacific Plate, where recent teleseismic tomography has shown evidence for a possible slab tear westward beneath the Sea of Japan. The character of the observed anomalous S wave attenuation and the following high-frequency coda can be captured with the two-dimensional (2-D) FDM simulation of seismic waves in heterogeneous plate model, incorporating the thinning of the plate at depth, which is also compared with other possible causes of dramatic attenuation of high-frequency S wave due to low-Q or much weaker heterogeneities in the slab. The results of simulation clearly demonstrate that the dramatic loss of high-frequency S wavefield from the plate into the surrounding mantle occurred due to the variation in the plate geometry (i.e., thinning of the plate) at depth near the source rather than due to variation in physical properties, such as due to the lowered-Q and weaker heterogeneities in the plate. The presence of such a thin zone defocuses the high-frequency slab-guided S wave energy from the subducting plate into the surrounding mantle and acts as a geometric antiwaveguide. Based on the sequence of simulation results obtained, we propose thinning of Pacific Plate at depth subducting beneath northeastern Japan, localized to central part of Honshu, in agreement with the observations.

  2. Japan

    OpenAIRE

    Suzuki, Kazujo

    2000-01-01

    Mit diesem Beitrag wird das Ziel verfolgt, einen ersten Überblick über die Lage der qualitativen Forschung in den Sozialwissenschaften in Japan zu geben. Dabei werden u.a. folgende Themenbereiche fokussiert: Qualitativ-psychologische Forschung (auch unter einer historischen Perspektive), das japanische Verständnis von Sozialwissenschaften, verwendete qualitative Verfahren, sowie die aktuelle Situation der qualitativen Forschung in der Psychologie und in anderen Sozial- und Humanwissenschaften...

  3. Japan's response to China's rise : regional engagement, global containment, dangers of collision

    OpenAIRE

    Hughes, Christopher W.

    2009-01-01

    Japan and China's ability to manage their bilateral relationship is crucial for the stability of the East Asian region. It also has a global impact on the security and economic development of other regions. For just as China's rise has inevitably involved an expansion of its global reach, so Japan's responses to the challenges posed by China have increasingly taken a global form, seeking to incorporate new partners and frameworks outside East Asia. Japan's preferred response to China's region...

  4. High-resolution Imaging of the Philippine Sea Plate subducting beneath Central Japan

    Science.gov (United States)

    Padhy, S.; Furumura, T.

    2016-12-01

    Thermal models predict that the oceanic crust of the young (PHP) is more prone to melting. Deriving a high-resolution image of the PHP, including slab melting and other features of the subduction zone, is a key to understand the basics of earthquake occurrence and origin of magma in complex subduction zone like central Japan, where both the PHP and Pacific (PAC) Plates subduct. To this purpose, we analyzed high-resolution waveforms of moderate sized (M 4-6), intermediate-to-deep (>150 km) PAC earthquakes occurring in central Japan and conducted numerical simulation to derive a fine-scale PHP model, which is not constrained in earlier studies. Observations show spindle-shaped seismograms with strong converted phases and extended coda with very slow decay from a group of PAC events occurring in northern part of central Japan and recorded by high-sensitivity seismograph network (Hi-net) stations in the region. We investigate the mechanism of propagation of these anomalous waveforms using the finite difference method (FDM) simulation of wave propagation through the subduction zone. We examine the effects on waveform changes of major subduction zone features, such as the melting of oceanic crust in PHP, serpentinized mantle wedge, hydrated layer on the PAC due to slab dehydration, and anomaly in upper mantle between the PAC and PHP. Simulation results show that the waveform anomaly is primarily explained by strong scattering and absorption of high-frequency energy by the low-velocity anomalous mantle structure, with a strong coda excitation yielding spindle-shaped waveforms. The data are secondarily explained by melting of PHP in the basaltic crust. The location of the mantle anomaly is tightly constrained by the observation and evidence of PAC thinning in the region; these localized low-velocity structures aid in ascending the slab-derived fluids around the slab thinning. We expect that the results of this study will enhance our present understanding on the mechanism

  5. Assessment of individual radionuclide distributions from the Fukushima nuclear accident covering central-east Japan.

    Science.gov (United States)

    Kinoshita, Norikazu; Sueki, Keisuke; Sasa, Kimikazu; Kitagawa, Jun-ichi; Ikarashi, Satoshi; Nishimura, Tomohiro; Wong, Ying-Shee; Satou, Yukihiko; Handa, Koji; Takahashi, Tsutomu; Sato, Masanori; Yamagata, Takeyasu

    2011-12-01

    A tremendous amount of radioactivity was discharged because of the damage to cooling systems of nuclear reactors in the Fukushima No. 1 nuclear power plant in March 2011. Fukushima and its adjacent prefectures were contaminated with fission products from the accident. Here, we show a geographical distribution of radioactive iodine, tellurium, and cesium in the surface soils of central-east Japan as determined by gamma-ray spectrometry. Especially in Fukushima prefecture, contaminated area spreads around Iitate and Naka-Dori for all the radionuclides we measured. Distributions of the radionuclides were affected by the physical state of each nuclide as well as geographical features. Considering meteorological conditions, it is concluded that the radioactive material transported on March 15 was the major contributor to contamination in Fukushima prefecture, whereas the radioactive material transported on March 21 was the major source in Ibaraki, Tochigi, Saitama, and Chiba prefectures and in Tokyo.

  6. Extirpation of Hediste japonica (Izuka, 1908) (Nereididae, Polychaeta) in central Japan, evidenced by a museum historical collection.

    Science.gov (United States)

    Sato, Masanori; Sattmann, Helmut

    2009-05-01

    A total of 11 specimens of a nereidid polychaete, which had been collected from the inner part ("Bay of Miya" is the old place name) of lse Bay in central Japan and preserved in the Natural History Museum Vienna, were taxonomically examined. They were all identified as the brackishwater nereidid, Hediste japonica (Izuka, 1908), which was previously known only from the Ariake Sea and Seto Inland Sea in western Japan and the western coast of Korea. The new information indicates that this species formerly had a wider distribution extending to at least lse Bay in central Japan, though all Japanese populations of this species seem to have been extirpated except for a population remaining in the Ariake Sea.

  7. A Facebook's Responses to the 2011 Triple Catastrophe in Japan

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    have engendered global networks, I have frequented the Association of Overseas Technical Scholarships (AOTS)' Facebook group. In the wake of the earthquake on March 11, 2011, many greetings came in from alumni who have within the last 50 years attended overseas training courses in Japan, which have...

  8. Modelling psychological responses to the Great East Japan earthquake and nuclear incident.

    Directory of Open Access Journals (Sweden)

    Robin Goodwin

    Full Text Available The Great East Japan (Tōhoku/Kanto earthquake of March 2011 was followed by a major tsunami and nuclear incident. Several previous studies have suggested a number of psychological responses to such disasters. However, few previous studies have modelled individual differences in the risk perceptions of major events, or the implications of these perceptions for relevant behaviours. We conducted a survey specifically examining responses to the Great Japan earthquake and nuclear incident, with data collected 11-13 weeks following these events. 844 young respondents completed a questionnaire in three regions of Japan; Miyagi (close to the earthquake and leaking nuclear plants, Tokyo/Chiba (approximately 220 km from the nuclear plants, and Western Japan (Yamaguchi and Nagasaki, some 1000 km from the plants. Results indicated significant regional differences in risk perception, with greater concern over earthquake risks in Tokyo than in Miyagi or Western Japan. Structural equation analyses showed that shared normative concerns about earthquake and nuclear risks, conservation values, lack of trust in governmental advice about the nuclear hazard, and poor personal control over the nuclear incident were positively correlated with perceived earthquake and nuclear risks. These risk perceptions further predicted specific outcomes (e.g. modifying homes, avoiding going outside, contemplating leaving Japan. The strength and significance of these pathways varied by region. Mental health and practical implications of these findings are discussed in the light of the continuing uncertainties in Japan following the March 2011 events.

  9. Modelling psychological responses to the Great East Japan earthquake and nuclear incident.

    Science.gov (United States)

    Goodwin, Robin; Takahashi, Masahito; Sun, Shaojing; Gaines, Stanley O

    2012-01-01

    The Great East Japan (Tōhoku/Kanto) earthquake of March 2011 was followed by a major tsunami and nuclear incident. Several previous studies have suggested a number of psychological responses to such disasters. However, few previous studies have modelled individual differences in the risk perceptions of major events, or the implications of these perceptions for relevant behaviours. We conducted a survey specifically examining responses to the Great Japan earthquake and nuclear incident, with data collected 11-13 weeks following these events. 844 young respondents completed a questionnaire in three regions of Japan; Miyagi (close to the earthquake and leaking nuclear plants), Tokyo/Chiba (approximately 220 km from the nuclear plants), and Western Japan (Yamaguchi and Nagasaki, some 1000 km from the plants). Results indicated significant regional differences in risk perception, with greater concern over earthquake risks in Tokyo than in Miyagi or Western Japan. Structural equation analyses showed that shared normative concerns about earthquake and nuclear risks, conservation values, lack of trust in governmental advice about the nuclear hazard, and poor personal control over the nuclear incident were positively correlated with perceived earthquake and nuclear risks. These risk perceptions further predicted specific outcomes (e.g. modifying homes, avoiding going outside, contemplating leaving Japan). The strength and significance of these pathways varied by region. Mental health and practical implications of these findings are discussed in the light of the continuing uncertainties in Japan following the March 2011 events.

  10. Tephrostratigraphy during 3000 years recorded in the sedimentary sequence of Beppu Bay, central Kyushu, Japan

    Science.gov (United States)

    Takemura, K.; Yamada, K.; Kuwae, M.; Yamamoto, M.; Danhara, T.

    2012-12-01

    The tephrostratigraphy around Beppu Bay, central Japan, is investigated using a 9m-long sedimentary core (KT09-3) collected in 2009 with a piston corer. Beppu Bay is located to the east of active volcanic region in Kyushu Island in southwest Japan. Eruptive history of their active volcanoes and widespread tephra records may be preserved in the sedimentary sequence in bay environment. A method to determine the down-hole content of volcanic glass was used in this study. This method consists of four steps: (1) continuous measurement of magnetic susceptibility with lithological observation of sediments, (2) systematic separation of the volcanic glass particles from samples taken at close intervals, and the determination of relative concentration; (3) mineral assemblages counted in the size of 63-125 micro meter fraction; (4) precise measurement of the refractive indices of the separated glass particles. A refractive index measuring system (RIMS) based on the thermal immersion method permitted quick and accurate measurement of the refractive index of a large number of samples. Core (KT09-3) is one of fourteen piston and gravity cores which were retrieved at the center of the basin. Correlation of cores was conducted using sand and silt seams related by events such as turbidite or flood or volcanic ash air fall, and the age-depth model was created by wiggle-matching of forty-two AMS radiocarbon dates from bivalve mollusk shells and excess Pb-210 and Cs-137 concentrations (Kuwae et al., 2012). The sedimentation rates were 230-300 cm/ky. Core is composed of massive diatomaceous clays with 18 event sediments of coarse fractions. Two distinct volcanic ash horizons and several cryptically deposited horizons are found within the sequence. Upper distinct volcanic ash of 509.2 cm depth is composed of many volcanic glasses and heavy minerals of Opx and Cpx with GHb and BHb. Most of volcanic glasses have characteristic high refractive index of about 1.559. This tephra is

  11. Purification of dialysis water in the central dialysis fluid delivery system in Japan: a prospective observation study.

    Science.gov (United States)

    Uchino, Junji; Kawasaki, Tadayuki

    2009-01-01

    Whereas the main measure of dialysis fluid purity is endotoxin (ET) activity in Japan, it is the viability count in Western countries. Because of this difference, little information is available concerning dialysis fluid purity determined in terms of viability count in Japan. Under these circumstances a fact-finding investigation was planned and conducted concerning dialysis fluid purity to demonstrate the effectiveness of dialysis fluid purification measures. 93 medical institutions are equipped with the central dialysis fluid delivery system (CDDS) unique to Japan. Almost all medical institutions surveyed have achieved the purification level of ultrapure dialysis fluid after ETRF, but the methods of ETRF use and management widely vary with each institution so that early validation of the methods of evaluation of ET inhibition and system management is in urgent need. It is also important that simple universal microbial monitoring and purification procedures be diffused far and wide as suggested by the Purification Guidelines proposed by us.

  12. Geothermal structure of the Miura-Boso plate subduction margin, central Japan

    Science.gov (United States)

    Yamamoto, Yuzuru; Hamada, Yohei; Kamiya, Nana; Ojima, Takanori; Chiyonobu, Shun; Saito, Saneatsu

    2017-07-01

    We have constrained the geothermal structure of the Miura-Boso plate subduction margin, located in central Japan, using maximum paleo-temperature data derived from vitrinite reflectance measurements. We established that higher maximum paleo-temperatures are restricted to the western part of the early Miocene Hota accretionary complex (Hota and Hayama groups), indicating a spatial difference in the amount of slip upon the out-of-sequence thrust potentially associated with the Izu-Bonin Island Arc collision. The weakly deformed sedimentary sequences overlying the highly deformed Hota Group strata have much lower vitrinite reflectance values than the latter. This variation indicates that the sedimentary sequences of the trench slope experienced a markedly lower maximum burial depth than the relatively deep-buried and uplifted Hota accretionary complex. Conversely, maximum paleo-temperatures obtained for tectonic blocks hosted by the neighboring Mineoka ophiolite complex are very high: ca. 140 °C for the large, early Miocene Haccho Formation blocks, and 65-90 °C for the other blocks. This result suggests that the individual tectonic blocks enclosed in the ophiolite complex were subjected exhumation from depths of 3-5 km.

  13. Seismomagnetic models for earthquakes in the eastern part of Izu Peninsula, Central Japan

    Directory of Open Access Journals (Sweden)

    Y. Ishikawa

    1997-06-01

    Full Text Available Seismomagnetic changes accompanied by four damaging earthquakes are explained by the piezomagnetic effect observed in the eastern part of Izu Peninsula, Central Japan. Most of the data were obtained by repeat surveys. Although these data suffered electric railway noise, significant magnetic changes were detected at points close to earthquake faults. Coseismic changes can be well interpreted by piezomagnetic models in the case of the 1978 Near Izu-Oshima (M 7.0 and the 1980 East Off Izu Peninsula (M 6.7 earthquakes. A large total intensity change up to 5 nT was observed at a survey point almost above the epicenter of the 1976 Kawazu (M 5.4 earthquake. This change is not explained by a single fault model; a 2-segment fault is suggested. Remarkable precursory and coseismic changes in the total force intensity were observed at KWZ station along with the 1978 Higashi-Izu (M 4.9 earthquake. KWZ station is located very close to a buried subsidiary fault of the M 7.0 Near Izu-Oshima earthquake, which moved aseismically at the time of the M 7.0 quake. The precursory magnetic change to the M 4.9 quake is ascribed to aseismic faulting of this buried fault, while the coseismic rebound to enlargement of the slipping surface at the time of M 4.9 quake. This implies that we observed the formation process of the earthquake nucleation zone via the magnetic field.

  14. Erosion and sedimentation during the September 2015 flooding of the Kinu River, central Japan

    Science.gov (United States)

    Dan Matsumoto; Sawai, Yuki; Yamada, Masaki; Namegaya, Yuichi; Shinozaki, Tetsuya; Takeda, Daisuke; Fujino, Shigehiro; Tanigawa, Koichiro; Nakamura, Atsunori; Pilarczyk, Jessica E.

    2016-01-01

    Erosional and sedimentary features associated with flooding have been documented in both modern and past cases. However, only a few studies have demonstrated the relationship between these features and the corresponding hydraulic conditions that produced them, making it difficult to evaluate the magnitude of paleo-flooding. This study describes the characteristics associated with inundation depth and flow direction, as well as the erosional and sedimentary features resulting from the disastrous flooding of the Kinu River, central Japan, in September 2015. Water levels rose rapidly due to heavy rainfall that eventually overtopped, and subsequently breached, a levee in Joso City, causing destructive flooding on the surrounding floodplain. Distinctive erosional features are found next to the breached levee, while depositional features, such as a sandy crevasse-splay deposit are found further away from the breach. The deposit can be divided into three units based on sedimentary facies. The vertical and lateral changes of these sedimentary facies may be the result of temporal and spatial changes associated with flow during the single flooding event. These observations and quantitative data provide information that can be used to reveal the paleohydrology of flood deposits in the stratigraphic record, leading to improved mitigation of future flooding disasters. PMID:27677769

  15. Bacterial community in sclerotia of Cenococcum species and soil in sub-alpine forest, central Japan

    Science.gov (United States)

    Nonoyama, Y.; Narisawa, K.; Ohta, H.; Watanabe, M.

    2009-04-01

    Species of Cenococcum, ectomycorrhizal fungi, may be particularly abundant in cold- or nutrient-stressed habitats. The fungus is easily recognized by its jet-black hyphae, and distinct compact masses of fungal mycelium called sclerotia. They are hard, black, comparatively smooth and mostly spherical. Sclerotia are formed in rhizosphere and can provide sufficient inoculums for several years. The purpose of this study is to investigate bacterial community inside sclerotia, with an interest on contribution of sclerotia to microbial diversity in rhizosphere. To investigate bacterial community inside of the fungal sclerotia by 16S rDNA gene clone library, several hundred of sclerotia (ca. 1g) were collected from sub-alpine forest soil in central Japan. Furthermore, three sclerotium grains were applied to investigate internal bacteria community by culture method. The isolated bacterial strains were then proceeded to determine their 16S rDNA partial sequences. The predominant group determined by clone library analysis of 16S ribosomal RNA genes with DNA from the sclerotia was Acidobacteria in both sclerotia and soil. Bacterial community of sclerotia showed higher diversity compared to soil. On the contrary, bacterial flora isolated from single sclerotium differed each other. Additionally, the bacterial community was composed by limited species of related genus.

  16. Influence of dam reservoir on deep marine sedimentological environment : An example of the Kumano Trough, central Japan

    OpenAIRE

    2016-01-01

    Sedimentation rate (mass accumulation rate; MAR) of surface hemipelagic sediments in the Kumano Trough, a forearc basin approximately 2000 m deep off the eastern Kii Peninsula, central Japan, was estimated from excess Pb-210 radioactivity profile and dry bulk density of the core sample. The estimated excess Pb-210 radioactivity profile was subdivided into three segments. The top segment was inferred to be affected by biological mixing in the surface mixing layer (SML). In contrast, a differen...

  17. Effect of the surface geology on strong ground motions due to the 2016 Central Tottori Earthquake, Japan

    Science.gov (United States)

    Kagawa, Takao; Noguchi, Tatsuya; Yoshida, Shohei; Yamamoto, Shinji

    2017-08-01

    On October 21, 2016, an earthquake with Japan Meteorological Agency (JMA) magnitude 6.6 hit the central part of Tottori Prefecture, Japan. This paper demonstrates two notable effects of the surface geology on strong ground motions due to the earthquake. One is a predominant period issue observed over a large area. A seismic intensity of 6 lower on the JMA scale was registered at three sites in the disaster area. However, the peak ground acceleration ranged from 0.3 to 1.4 G at the three sites because of the varying peak periods of observed strong ground motions. The spectral properties of the observations also reflect the damage around the sites. Three-component microtremors were observed in the area; the predominant ground period distributions based on horizontal to vertical spectral ratios were provided by the authors. The peak periods of the strong motion records agree well with predominant periods estimated from microtremor observations at a rather hard site; however, the predominant periods of the microtremors are slightly shorter than those of the main shock at the other two soft sites. We checked the nonlinear effect at the sites by comparing the site responses to small events and the main shock. The peak periods of the main shock were longer than those of the weak motions at the sites. This phenomenon indicates a nonlinear site effect due to large ground motions caused by the main shock. A horizontal component of the accelerogram showed rather pulsating swings that indicate cyclic mobility behavior, especially at a site close to a pond shore; ground subsidence of 20 cm was observed around the site. The peak periods of weak motions agree well with those of the microtremor observations. This implies an important issue that the predominant periods estimated by microtremors are not sufficient to estimate the effect of surface geology for disaster mitigation. We have to estimate the predominant periods under large ground motions considering the nonlinear site

  18. Seismological Features of the Subducting Slab Beneath the Kii Peninsula, Central Japan, Revealed by Receiver Functions

    Science.gov (United States)

    Shiomi, K.; Park, J.

    2007-12-01

    We report seismological evidence that the subducting Philippine Sea slab (PHS) beneath the Kii Peninsula, central Japan, can be divided into three segments. Offshore the Kii Peninsula, the "Tonankai" and "Nankai" fault segments suffer mega-thrust earthquakes that repeat every 100 to 150 years. The structure of the young, thin, contorted PHS is important to the seismo-tectonics in this region. We apply the receiver function (RF) analysis to 26 Hi-net short-period and 4 F-net broad-band seismographic stations. In the case that dipping velocity discontinuities and/or anisotropic media exist beneath seismometer, both radial RFs and transverse RFs contain useful information to estimate underground structure. For isotropic media with a dipping-slab interface, back- azimuthal variation in RFs depends largely on three parameters, the downdip azimuth, dip angle and the depth of the interface. We stack both radial and transverse RFs with allowance a time-shift caused by the dipping interface, searching for optimal parameters based on the grid-search technique at each station. At some stations located near the eastern coastline of the Kii Peninsula, the dip angle of the interface inferred from RF stacking is much steeper than that estimated by the local seismicity. This discrepancy arises from the interference of two slab-converted phases, suggesting a layer atop the slab. In these cases we refine the stack to distinguish two slab phases and estimate three parameters of each dipping interface separately. Two interfaces with the same dip direction and low dip angle are estimated at these stations, with depth difference near 6 km. Thus, the shallower interface may be related to the layer within the oceanic crust and the deeper one is the slab Moho. These double-layered interfaces are detected only at stations located up-dip of a belt-like distribution of non- volcanic low-frequency tremor. Comparing the interface dips estimated in this study with the direction of slab motion

  19. Susceptible conditions for debarking by deer in subalpine coniferous forests in central Japan

    Institute of Scientific and Technical Information of China (English)

    Hayato Iijima; Takuo Nagaike

    2016-01-01

    Background:Recently, deer have expanded their distribution to higher altitude ranges including subalpine forests. However, culling deer and construction of deer fence in subalpine forests are difficult because of steep slopes and complex topography. Thus it is necessary to clarify the factors which are associated with debarking by deer for the effective protection of subalpine forests. In this study, we examined which factors are associated with debarking by sika deer (Cervus nippon) in subalpine coniferous forests. Methods:We conducted our survey in Minami-Alps National Park, central Japan. We established 24 10 m × 40 m plots and surveyed the occurrence of debarking on saplings>30 cm in height and3 cm in DBH, as well as sapling density within each plot. Minimum distances to nearest grassland of plots were calculated (tentatively assuming grassland would attract deer and would cause high debarking pressure in the surrounding subalpine forests). Results:The mean percentage of debarked live saplings was higher than that of live trees. The mean percentage of debarked saplings which had already died was 81.6 %. Debarking of saplings increased with lower elevation, taller sapling size, and marginally increased near grassland. Sapling density was lower in plots with low basal area of conspecific trees near grassland and differed among species. Sapling density marginally decreased with decreasing elevation and increasing stand tree density. Debarking of trees was positively related to small DBH and low elevation, and marginally increased near grassland and differed among species. Conclusions:Our results suggest that tall saplings in subalpine forests of low elevation or near subalpine grassland were susceptible to debarking by deer and monitoring of these areas may permit the early detection of the impacts of deer in subalpine coniferous forests.

  20. Growth, allometry and shade tolerance of understory saplings of four subalpine conifers in central Japan.

    Science.gov (United States)

    Takahashi, Koichi; Obata, Yoshiko

    2014-03-01

    The conifers Abies veitchii, A. mariesii, Picea jezoensis var. hondoensis, Tsuga diversifolia dominate in subalpine forests in central Japan. We expected that species differences in shade tolerance and in aboveground and belowground architecture are important for their coexistence. We examined net production and carbon allocation of understory saplings. Although the four species allocated similar amounts of biomass to roots at a given trunk height, the root-zone area of T. diversifolia was greater than that of the three other species. T. diversifolia often dominates shallow soil sites, such as ridge and rocky slopes, and, therefore, a wide spread of lateral roots would be an adaptation to such edaphic conditions. Crown width and leaf and branch mass were greatest for T. diversifolia and A. mariesii, followed in order by A. veitchii and P. jezoensis var. hondoensis. Although leaf mass of P. jezoensis var. hondoensis was lowest among the four species, species differences were not found in the net production per sapling because net production per leaf mass was greatest for P. jezoensis var. hondoensis. The leaf lifespan was longer in the order A. mariesii, T. diversifolia, P. jezoensis var. hondoensis and A. veitchii. The minimum rate of net production per leaf mass required to maintain the current sapling leaf mass (MRNP(LM)) was lowest in A. mariesii and T. diversifolia, and increased in the order of A. veitchii and P. jezoensis var. hondoensis. A. mariesii and T. diversifolia may survive in shade conditions by a lower MRNP(LM) than the two other species. Therefore, species differences in aboveground and belowground architecture and MRNPLM reflected their shade tolerance and regeneration strategies, which contribute to their coexistence.

  1. Imaging the spatiotemporal evolution of a slow slip event near the Boso Peninsula, central Japan

    Science.gov (United States)

    Fukuda, J.; Kato, A.; Obara, K.; Miura, S.; Kato, T.

    2015-12-01

    Continuous GPS measurements have identified numerous slow slip events (SSEs), but our knowledge of the spatiotemporal evolution of SSEs remains limited. For example, the detailed spatiotemporal correlation between slow slip and its associated seismic activity has not been well resolved, and we have limited knowledge of SSE nucleation. Thus, elucidating the detailed spatiotemporal evolution of SSEs may help constrain the physics of SSEs and their associated seismic activity. In this study, we use a modified version of the Network Inversion Filter (NIF) to investigate the detailed spatiotemporal evolution of SSEs including the nucleation and spatiotemporal correlations with seismicity. We focus on a SSE that occurred near the Boso Peninsula, in central Japan, from December 2013 to January 2014. We apply the modified NIF to GPS time series to estimate the spatiotemporal evolution of daily cumulative slip and slip rate on the subducting Philippine Sea plate. We find that the evolution of the SSE and its associated seismicity is divided into two distinct phases. Slip initially accelerated slowly with low slip rates, low propagation speeds, and no accompanying seismicity during the early phase, and then accelerated more rapidly with higher slip rates, a higher propagation speed, and local earthquake swarm activity during the later phase. The seismicity was highly correlated in space and time with slip rate, suggesting that the swarm activity was triggered by stress loading due to the slow slip. The transition from the slow to faster phase shares some similarities with the nucleation of megathrust earthquakes inferred from foreshock activities, suggesting that SSEs may provide insights into the nucleation of large earthquakes.

  2. Recent Intermediate Depth Earthquakes in El Salvador, Central Mexico, Cascadia and South-West Japan

    Science.gov (United States)

    Lemoine, A.; Gardi, A.; Gutscher, M.; Madariaga, R.

    2001-12-01

    We studied occurence and source parameters of several recent intermediate depth earthquakes. We concentrated on the Mw=7.7 salvadorian earthquake which took place on January 13, 2001. It was a good example of the high seismic risk associated to such kind of events which occur closer to the coast than the interplate thrust events. The Salvadorian earthquake was an intermediate depth downdip extensional event which occured inside the downgoing Cocos plate, next to the downdip flexure where the dip increases sharply before the slab sinks more steeply. This location corresponds closely to the position of the Mw=5.7 1996 and Mw=7.3 1982 downdip extensional events. Several recent intermediate depth earthquakes occured in subduction zones exhibiting a ``flat slab'' geometry with three distinct flexural bends where flexural stress may be enhanced. The Mw=6.7 Geiyo event showed a downdip extensional mechanism with N-S striking nodal planes. This trend was highly oblique to the trench (Nankai Trough), yet consistent with westward steepening at the SW lateral termination of the SW Japan flat slab. The Mw=6.8 Olympia earthquake in the Cascadia subduction zone occured at the downdip termination of the Juan de Fuca slab, where plate dip increases from about 5o to over 30o. The N-S orientation of the focal planes, parallel to the trench indicated downdip extension. The location at the downdip flexure corresponds closely to the estimated positions of the 1949 M7.1 Olympia and 1965 M6.5 Seattle-Tacoma events. Between 1994 and 1999, in Central Mexico, an unusually high intermediate depth seismicity occured where several authors proposed a flat geometry for the Cocos plate. Seven events of magnitude between Mw=5.9 and Mw=7.1 occured. Three of them were downdip compressional and four where down-dip extensional. We can explain these earthquakes by flexural stresses at down-dip and lateral terminations of the supposed flat segment. Even if intermediate depth earthquakes occurence could

  3. Emission of Nitrous Oxide in Temperate Forests with Different Stages of Nitrogen Saturation in Central Japan

    Science.gov (United States)

    Shaoyan, F.

    2015-12-01

    Long-term nitrogen deposition has caused a problem called nitrogen saturation in forest ecosystems globally. Aber et al. (1989) suggested that nitrogen saturation activate soil nitrification in forest systems, which is the main process of N2O production in aerobic condition. Thus, nitrogen saturation may affect significantly the N2O emission from forests, while the impact on flux has not been quantitatively evaluated yet. In the present study, 3-year monitoring of N2O emission was performed in an N-saturated forests (Tama Hill, Tokyo): the emission rate of N2O was measured monthly by a closed chamber method at 12 plots along a slope, and the net nitrification rate of surface soil (0-10 cm) was measured 4 times in situ. In addition, a comparative research was conducted in summer in eight temperate forests with different stages of nitrogen saturation in central Japan; the N2O flux, soil moisture, nitrogen availability and stream water NO3- concentration were measured at each site. In an N-saturated forests, the annual N2O emission was estimated to be 0.88 kg N ha-1year-1 , showing a typical seasonal variation . The seasonal patterns of N2O emission were significantly related to soil moisture and ambient temperature. We also found high spatial variation of N2O flux among 12 plots along the slope, which was generally higher at the bottom. Moreover, a positive correlation was found between the rate of N2O emission and the net nitrification rate with WFPS60% , probably due to the effect of denitrification. In comparison sites, the N2O emission rate ranged nearly 16-fold from 0.13-2.11 g N ha-1day-1 was linearly related to the stream water NO3- concentration ranged 10-fold from 0.14 to 1.4 mg N/L. Our results revealed N enrichment in forest obviously stimulate soil N2O emission. Keywords: Nitrous oxide, nitrogen saturation, nitrification, temperate forest

  4. Shallow seismic section in the central Kanto plain, to the north of Tokyo metropolitan area, Japan

    Science.gov (United States)

    Yamaguchi, K.; Kano, N.; Ohtaki, T.; Yokokura, T.; Ito, S.; Sumita, T.; Makino, M.; Yokota, T.; Kimura, H.

    2008-12-01

    Shallow seismic reflection surveys were carried out in the central part of the Kanto plain, 40 km northwest of Tokyo, Japan. The survey target ranges about from 50 m to 500 m in depth. The final purpose of the surveys is to reveal the relationship between the subsurface structure and the distribution and flow of the underground water in this area. The survey lines were divided into Kawagoe1(length of CMP line: 8km), Okegawa1(5.3km), Shobu1(8.7km) and Kazo1(6.3km). They line up southwest to northeast from the Iruma upland to the Kazo lowland via the Arakawa lowland and Omiya upland. The survey lines cross the Arakawa fault, the Ayasegawa fault and the Kuki fault. They are considered active, but only the Aysegawa fault has fault topography and is confirmed by subsurface structure. The total length of the lines is about 27km and there is a 2 km long opening between the Okegawa1 and the Shobu1, because of dense population and heavy traffic. Survey parameters are as follows. Seismic source: one EnviroVib or MiniVib or Mini Impactor, shot interval: 2.5m or 10m, sweep frequency: 15-120Hz, sweep length: 13s, receiver: UltraMark2, receiver interval: 10m, elements: 6 bunching, recording instrument: DAS-1, number of channel: 144, listening length: 3.3s, spread: shots from the edge to the 48th point of 144 fixed receiver points, maximum offset: between 1440m and 960m. The data were processed to make seismic sections for each survey line by conventional CMP method. Then the sections were cut and pasted into a series of seismic sections. Many continuous reflectors are imaged between several ten meters and 1 km in depth in the whole seismic section. Reflectors are discontinuous below 1 km, probably because of lack of source energy. In the Iruma upland and Arakawa lowland, the Pliocene and Pleistocene units thicken northeastward, indicating that sedimentation has been synchronous with northeastward tilting of the underlying basement rocks. Undulation and bending of reflectors

  5. Overland flow connectivity in a forest plantation before and after tree thinning (Tochigi Prefecture, central Japan)

    Science.gov (United States)

    López-Vicente, Manuel; Onda, Yuichi; Sun, Xinchao; Kato, Hiroaki; Gomi, Takashi; Hiraoka, Marino

    2016-04-01

    Overland flow connectivity is a key factor to understand the redistribution dynamics of sediments, nutrients, radiotracers, etc., in the different compartments at channel, hillslope and catchment scales. Human organization of landscape elements has a significant control on runoff and soil redistribution processes. Construction of trails, forest roads and firewalls influence runoff connectivity (RC) in forested catchments. In this study we simulated RC in two forested catchments, called K2 (19.3 ha) and K3 (13.6 ha), located on the Mount Karasawa, in the Tochigi Prefecture in central Japan. Forest plantation includes Japanese cypress and cedar and covers 59% of the total area. Native broad-leaved trees (28%) and mixed forest occupy the rest of the study area. We selected the Index of runoff and sediment Connectivity (IC) of Borselli et al. (2008) to simulate three temporal scenarios: i) Sc-2011, before tree thinning (TT); ii) Sc-2012 after TT in most part of the forest plantation in K2 (32% of the total area); and iii) Sc-2013 after TT in some areas of the K3 catchment, affecting 38% of the total area. The study areas were defined from the coalescence point (139⁰ 36' 04" E, 36⁰ 22' 03" N) of both catchments upslope. Elevation ranges from 75 to 287 m a.s.l. and the mean slope steepness is of 67 and 65% in K2 and K3. Three different high resolution DEM-LiDAR maps at 0.5 x 0.5 m of cell size were used to run the IC model in each scenario. The permanent streams in the study area have a total length of 2123 m. The mean C-RUSLE factor was of 0.0225 in Sc-2011 and 21% and 25% higher in Sc-2012 and Sc-2013. The total length of the landscape linear elements incremented from 2482 m in Sc-2011 to 3151 m in Sc-2012 and Sc-2013 due to the construction of new skid trails in K2. The mean RC in the study area was of -4.536 in Sc-2011 and increased 7.4% and 8.9% in the Sc-2012 and Sc-2013, respectively, due to the tree thinning operations and the construction of new skid trails

  6. Structural Analysis of Serpentinite in the Jikkoku Pass Area, Northwestern Kanto Mountains, Central Japan

    Science.gov (United States)

    Hirauchi, K.; Hisada, K.

    2004-12-01

    Serpentinite is a product made by hydrothermal alteration of ultramafic rocks such as peridotite. It has been understood that serpentinite along a fault or a plate boundary plays a role as a lubricant for rheological properties. However, it is unknown how serpentinite actually acts through its deformation processes. The study area is located on the Jikkoku Pass area, northwestern Kanto Mountains, central Japan. Serpentinite bodies are intermittently distributed along fault boundaries. In this study, we divided serpentinite into four deformation stages (D1-D4) based on meso- and microstructures. 1) D1 stage: It is represented by block-in-matrix structure. Block sizes are various, and their longest axis is about 1 m. Shapes of blocks are almost oblate type and rounded to subangular. The long axes of blocks nearly show a same orientation, and planar structures are nearly parallel to them. Inner structures of blocks are entirely deformed, and mesh texture as a pseudomorph of olivine and euhedral chromian spinels are observed. Serpentines consist mainly of lizardite and chrysotile. Fine-gained serpentines of various sizes are randomly scattered in the matrix. 2) D2 stage: It is represented by alternation in portions of different colors and textures. Colors consist mainly of dark green and yellowish green. Intervals of this alternation vary from 1 to 3 mm. In portions of dark green, needle-shaped antigorites have a preferred orientation. Antigorites are remarkably fine-grained in some cases, and are similar to characteristics of ultramylonite. Portions of yellowish green include opaque minerals such as magnetite, forming planar structures. A chromian spinel occurs as a porphyroclast (rounded shape) together with fine-grained recrystallized antigorites. 3) D3 stage: It is represented by fracture foliation. It is formed by foliation as fracture planes that are penetratively developed with a few hundreds of ƒEm intervals. Besides, intervals of this foliation also vary on

  7. Central Congenital Hypothyroidism Detected by Neonatal Screening in Sapporo, Japan (2000-2004): It's Prevalence and Clinical Characteristics.

    Science.gov (United States)

    Fujiwara, Fumie; Fujikura, Kaori; Okuhara, Koji; Tsubaki, Jyunko; Fukushi, Masaru; Fujita, Kozo; Fujieda, Kenji; Tajima, Toshihiro

    2008-01-01

    In Sapporo, Japan, a neonatal screening program for congenital hypothyroidism (CH) has employed measurement of free thyroxine (T4) and TSH in the same filter-paper blood spot. This system has enabled us to identify primary CH and central CH during the neonatal period. The aim of this study was to clarify the prevalence and clinical characteristics of central CH. For this purpose, the screening program requested serum from infants with free T4 concentrations below the cut off value regardless of the TSH levels. Between January 2000 and December 2004, 83,232 newborns were screened and six central CH patients were detected as a result of follow-up of low free T4 and non-elevated TSH screening (1:13,872). This frequency is higher than in other studies. Four patients showed multiple pituitary hormone deficiency with pituitary malformations on magnetic resonance imaging. One patient was diagnosed as having Prader-Willie syndrome. The remaining patient was considered to have isolated central CH. Our study demonstrated that the frequency of central CH is 1:13,872. Free T4 measurement would also be advantageous in early recognition of multiple pituitary hormone deficiency.

  8. Comparison of wood-inhabiting myxomycetes in subalpine and montane coniferous forests in the Yatsugatake Mountains of Central Japan.

    Science.gov (United States)

    Takahashi, Kazunari; Harakon, Yuichi

    2012-05-01

    To demonstrate altitudinal gradients (and resulting temperatures) that affect myxomycete biodiversity and species composition, we statistically compared myxomycete assemblages between a subalpine coniferous forest and a montane pine forest within the region of the Yatsugatake Mountains, Nagano Prefecture, Central Japan. In summer and autumn field surveys during 2003-2010, 53 myxomycete taxa (with varieties treated as species) were observed from 639 records of fruiting bodies in the subalpine forest and 32 taxa were detected from 613 records in the montane forest. There were 20 species in common between the assemblages and the percentage similarity index was 0.400. Myxomycete biodiversity was higher in the subalpine than in the montane forest. Nine myxomycete species were statistically frequent occurrences in the subalpine forest and appeared in autumn: Lamproderma columbinum, Cribraria macrocarpa, Trichia botrytis, Physarum newtonii, Diderma ochraceum, Enteridium splendens, Elaeomyxa cerifera, Trichia verrucosa, and Colloderma oculatum. Five species were restricted to appear in the subalpine forest: Cribraria purpurea, Cribraria rufa, Cribraria ferruginea, Cribraria piriformis, and Lepidoderma tigrinum. Dead wood in the subalpine forest provided a breeding habitat for specific myxomycetes that inhabit cold areas; that is those areas having geographical features of decreasing temperature and increasing elevation, such as the temperate area of Central Japan.

  9. The Centralization and Decentralization of Telemedicine Networks in Korea and Japan

    OpenAIRE

    Soo-kyung Park

    2013-01-01

    This study scrutinizes telemedicine networks with regard to regionalization and the propensities and determinants of core telemedicine users (doctors and patients) by employing two case areas, Choongbook in Korea and Kagawa in Japan. According to the results, telemedicine networks in Choongbook are dominated by an inter-regional level (in particular, a national level), and most of the telemedicine networks are observed between clinical sites in Choongbook and tertiary care centers in Kyunggi....

  10. Nuclear power plants making a comeback in Japan; El retorno de la centrales nucleares en Japon

    Energy Technology Data Exchange (ETDEWEB)

    Torralbo, J. R.

    2016-08-01

    We reproduce in this magazine the interesting article published by the president of the SNE in issue 46 of Cuadernos de Energia in October 2015, which describes the events that have taken place since the March 11, 2011 earthquake in Japan, the largest in its history, and the subsequent tsunami, which affected the Fukushima power plant, as well as the measures implemented since then and how some of this country nuclear power plants are being started up again. (Author)

  11. [A new stream of the next disaster response with a variety of hospital ship in Japan].

    Science.gov (United States)

    Kato, Soichiro; Yamaguchi, Yoshihiro

    2016-02-01

    In Japan, experience from an earthquake has always provided an opportunity to reconsider measures of disaster preparedness. To facilitate decision-making and its enforcement in a large-scale disaster response, a cross-agency organization and tough infrastructure are required as a foundation of crisis management. In the Fukushima nuclear power plant accident, the Fukushima Nuclear Disaster Management Center could not perform their mission due to the collapse of various infrastructure caused by the earthquake. The archipelago structure of Japan is easy terrain that provides approach from the shore to any place in the country; this makes it possible to plan effective relief operations. Therefore, in preparing for the next large-scale disaster, the use of a hospital ship has been discussed as one of the strong bases to combat collapse of infrastructure. For effective utilization of the ship, we will discuss the main points collated from experience of past disaster responses and training.

  12. Conflicting views on elder care responsibility in Japan.

    Science.gov (United States)

    Lee, Kristen Schultz

    2016-05-01

    I examine the attitudinal ambivalence created by conflicting social expectations regarding parent-child devotion, filial obligation and family membership, and gender norms in a national population of Japanese adults. I ask: in a context of rapidly changing family and elder care norms, how do different beliefs and attitudes overlap and conflict and how are they related to elder care preferences? I analyze data from the 2006 Japanese General Social Survey and use Latent Class Analysis to identify latent groups in the population defined by their beliefs and examine the relationship between class membership and elder care preferences. I found variation in the population with respect to the measured beliefs as well as a relationship between patterns of beliefs and choice of elder caregiver. I found conflicting expectations regarding elder care responsibility in one latent class and this class also expressed elder care preferences that conflict with at least some of their strongly held beliefs.

  13. Hypersensitivity Responses in the Central Nervous System

    DEFF Research Database (Denmark)

    Khorooshi, Reza; Asgari, Nasrin; Mørch, Marlene Thorsen

    2015-01-01

    of pathology in neuromyelitis optica (NMO), a central nervous system (CNS) demyelinating disease where activated neutrophils infiltrate, unlike in MS. The most widely used model for MS, experimental autoimmune encephalomyelitis, is an autoantigen-immunized disease that can be transferred to naive animals...

  14. Wide-angle seismic survey in the trench-outer rise region of the central Japan Trench

    Science.gov (United States)

    Fujie, G.; Kodaira, S.; Iwamaru, H.; Shirai, T.; Dannowski, A.; Thorwart, M.; Grevemeyer, I.; Morgan, J. P.

    2015-12-01

    Dehydration process within the subducting oceanic plate and expelled water from there affect various subduction-zone processes, including arc volcanism and generation of earthquakes. This implies that the degree of hydration within the incoming oceanic plate just prior to subduction might be a key control factor on the regional variations in subduction zone processes like interplate earthquakes and arc volcanism. Recent advances in seismic structure studies in the trench-outer rise region of the Japan Trench have revealed that seismic velocities within the incoming oceanic plate become lower owing to the plate bending-related faulting, suggesting the hydration of the oceanic plate. If the degree of the oceanic plate hydration is one of key factors controlling the regional variations of the interplate earthquakes, the degree of the oceanic plate hydration just prior to subduction is expected to show the along-trench variation because the interplate seismicity in the forearc region of the Japan Trench show along-trench variations. However, we cannot discuss the along-trench variation of the incoming plate structure because seismic structure studies have been confined only to the northern Japan Trench so far.In 2014 and 2015, JAMSTEC and GEOMAR conducted wide-angle seismic surveys in the trench-outer rise region of the central Japan Trench to reveal the detailed seismic structure of the incoming oceanic plate. The western extension of our survey line corresponds to the epicenter of the 2011 M9 Tohoku earthquakes. We deployed 88 Ocean Bottom Seismometers (OBSs) at intervals of 6 km and shot a tuned air-gun array of R/V Kairei at 200 m spacing. In this presentation, we will show the overview of our seismic survey and present seismic structure models obtained by the data of mainly 2014 seismic survey together with the several OBS data from 2015 survey. The preliminary results show P-wave velocity (Vp) within the oceanic crust and mantle decreases toward the trench axis

  15. Using Online Tools to Assess Public Responses to Climate Change Mitigation Policies in Japan

    Directory of Open Access Journals (Sweden)

    Nophea Sasaki

    2011-04-01

    Full Text Available As a member of the Annex 1 countries to the Kyoto Protocol of the United Nations Framework Convention on Climate Change, Japan is committed to reducing 6% of the greenhouse gas emissions. In order to achieve this commitment, Japan has undertaken several major mitigation measures, one of which is the domestic measure that includes ecologically friendly lifestyle programs, utilizing natural energy, participating in local environmental activities, and amending environmental laws. Mitigation policies could be achieved if public responses were strong. As the internet has increasingly become an online platform for sharing environmental information, public responses to the need for reducing greenhouse gas emissions may be assessed using available online tools. We used Google Insights for Search, Google AdWords Keyword Tool, and Google Timeline View to assess public responses in Japan based on the interest shown for five search terms that define global climate change and its mitigation policies. Data on online search interests from January 04, 2004 to July 18, 2010 were analyzed according to locations and categories. Our study suggests that the search interests for the five chosen search terms dramatically increased, especially when new mitigation policies were introduced or when climate change related events were organized. Such a rapid increase indicates that the Japanese public strongly responds to climate change mitigation policies.

  16. Lateral variation of H2O contents in Quaternary Magma of central Northeastern Japan arc

    Science.gov (United States)

    Miyagi, I.; Matsu'ura, T.; Itoh, J.; Morishita, Y.

    2011-12-01

    Water plays a key role in the genesis and eruptive mechanisms of subduction zone volcanoes. We estimated bulk rock water content of both frontal and back arc volcanoes from Northeastern Japan arc in order to understand the lateral variation of magmatic H2O contents in the island arc magma. Our analytical targets are the Adachi volcano located near the volcanic front and the Hijiori volcano located on back arc side. In this study, the bulk magmatic H2O content is estimated by a simple mass balance calculation of the chemistry of bulk rock and melt inclusions in phenocrysts; the melt H2O contents of melt inclusions analyzed by SIMS or EPMA are corrected according to the difference in K2O content between melt inclusions and bulk rock. The bulk magmatic H2O we obtained is 8 wt. % or even more for Adachi and is 2-3 wt. % for Hijiori. Thus, the frontal volcano has higher H2O than the back arc volcano. Although our data are opposed to the previous estimation on the lateral variation of H2O contents in Quaternary volcanoes of Northeastern Japan arc (e.g., Sakuyama, 1979), thermodynamic computations using MELTS (Ghiorso and Sack, 1995) suggest that the amount of bulk magmatic H2O we estimated is consistent with petrographical observations. Our data imply a regional characteristics in the type of eruption that the H2O rich frontal volcanoes will erupt explosively and those H2O poor back arc ones will be effusive, which implication is consistent with actual geological observations that volcanoes located on back arc side of the Northeastern Japan arc generally comprise lava flow (e.g., Iwaki, Kanpu, Chokai, Gassan), in contrast to the frontal ones that produced voluminous tephra (e.g., Osorezan, Towada, Narugo, Adachi). This research project has been conducted under the research contract with Nuclear and Industrial Safety Agency (NISA).

  17. Estradiol and osmolality: Behavioral responses and central pathways.

    Science.gov (United States)

    Curtis, Kathleen S

    2015-12-01

    Regulation of appropriate osmolality of body fluid is critical for survival, yet there are sex differences in compensatory responses to osmotic challenges. Few studies have focused on the role of sex hormones such as estradiol in behavioral responses to increases or decreases in systemic osmolality, and even fewer studies have investigated whether central actions of estrogens contribute to these responses. This overview integrates findings from a series of ongoing and completed experiments conducted in my laboratory to assess estradiol effects on water and NaCl intake in response to osmotic challenges, and on activity in central pathways that mediate such responses.

  18. Moral Education in Japan

    DEFF Research Database (Denmark)

    Roesgaard, Marie Højlund

    What is a ‘good’ person and how do we educate ‘good’ persons? This question of morality is central to any society and its government and educational system including the Japanese. In many societies it has been customary to teach about morality from a religious standpoint, but not so in Japan, where....... It places moral education within the context of globalization and cosmopolitanism and shows, that moral education in Japan is a useful key to understanding how globalization and cosmopolitanism can work within a specific system, in this case Japanese values education. In recent years various changes...... political focus on moral education in Japan, particularly by the two Abe-administrations. Changes include for example increased emphasis on patriotism, on respect for life and the environment, on individual responsibility, on respecting differences and other countries and on a general strengthening of moral...

  19. Measurements of atmospheric hydroperoxides over a rural site in central Japan during summers using a helicopter

    Science.gov (United States)

    Watanabe, Koichi; Yachi, Chinatsu; Nishibe, Miyuki; Michigami, Serina; Saito, Yukiko; Eda, Nagisa; Yamazaki, Nobuhiro; Hirai, Taiki

    2016-12-01

    The concentrations of hydroperoxides (H2O2 and MHP), O3, SO2 and NOX* over Imizu City, Toyama Prefecture, Japan were measured during summers using a helicopter. The concentrations of hydroperoxides were analyzed by an HPLC system within 5-10 min after the sampling. The H2O2 concentration was lowest at the surface, and the highest concentration was detected at altitudes of 6000 and 8000 ft. The MHP was also higher in the high-altitude atmosphere. Significantly high concentrations of hydroperoxides were observed when air pollutants were transported from China. The concentration of H2O2 was higher than that of SO2 above 4000 ft where the potential capacity of SO2 oxidation in the aqueous phase is large. A helicopter is useful for measuring of hydroperoxides in the high-altitude atmosphere using an HPLC system in a laboratory.

  20. Characteristics of overland flow generation on steep forested hillslopes of central Japan

    Science.gov (United States)

    Gomi, Takashi; Sidle, Roy C.; Ueno, Masayasu; Miyata, Shusuke; Kosugi, Ken'ichirou

    2008-11-01

    SummaryOverland flow generation was monitored in large plots (8 × 25 m) on four hillslopes in a 4.9-ha catchment in Mie Prefecture, Japan. Three Japanese cypress (hinoki, Chamaecyparis obtusa) treatments (including three different understory conditions) and one deciduous forest treatment were studied. For all plots, including deciduous hillslopes, we observed overland flow even for small storm events (180 mm, runoff from Japanese cypress plots with dense fern understory exhibited a delayed and higher peak associated with return flow. The dominance of hillslope-scale flow contribution to catchment runoff was also affected by changes in the dominance of overland flow and return flow. Understory vegetation cover and the availability of a litter layer altered the amount of overland flow, which was mediated by soil water repellency and soil moisture. Observations at the hillslope scale are essential for conceptualization of runoff mechanisms and pathways in forested headwaters.

  1. Prevalence of food-responsive enteropathy among dogs with chronic enteropathy in Japan.

    Science.gov (United States)

    Kawano, Koji; Shimakura, Hidekatsu; Nagata, Noriyuki; Masashi, Yuki; Suto, Akemi; Suto, Yukinori; Uto, Shohei; Ueno, Hiromichi; Hasegawa, Takehiro; Ushigusa, Takahiro; Nagai, Takashi; Arawatari, Yasunori; Miyaji, Kazuki; Ohmori, Keitaro; Mizuno, Takuya

    2016-09-01

    There have been limited reports on the prevalence of adverse food reactions among dogs suffering from chronic enteropathy (CE) in Japan. We examined the prevalence and histological features of food-responsive enteropathy (FRE) in a total of 32 dogs with history of CE. Fourteen of 18 cases (56.2%) diagnosed as FRE had lymphocytic-plasmacytic enteritis or eosinophilic enteritis by histopathological examination. Characteristic histopathological changes indicating FRE were not identified in 18 cases, though 4 cases did not show any abnormalities. Results collected from this study provided important information that can help to change the way dogs with CE are treated in the future.

  2. China’s Energy Strategy in Central Asia: Interactions with Russia, India and Japan

    Directory of Open Access Journals (Sweden)

    Irina Pop

    2010-10-01

    Full Text Available La estrategia de seguridad energética de China y sus inversiones en ultramar son el sujeto de un intenso debate. Asia Central es una región colindante, rica en reservas de petróleo y gas, que parece ser la más susceptible de jugar un papel importante en la estrategia china de reducción de la dependencia de suministros de Oriente Próximo. Por tanto, este artículo va a intentar evaluar la estrategia energética china hacia Asia Central, analizando las siguientes cuestiones: los intereses de China en la región, su estrategia de seguridad energética con respecto a su diplomacia energética y sus inversiones en Asia Central, y las interacciones con Rusia, la India y Japón en el campo de la energía. Este artículo finaliza con conclusiones y comentarios sobre: la influencia de los factores geopolíticos y geo-estratégicos con respecto a la eficiencia, durabilidad y desarrollos potenciales de la estrategia energética de China en Asia Central.

  3. Surface rupturing earthquakes repeated in the 300 years along the ISTL active fault system, central Japan

    Science.gov (United States)

    Katsube, Aya; Kondo, Hisao; Kurosawa, Hideki

    2017-06-01

    Surface rupturing earthquakes produced by intraplate active faults generally have long recurrence intervals of a few thousands to tens of thousands of years. We here report the first evidence for an extremely short recurrence interval of 300 years for surface rupturing earthquakes on an intraplate system in Japan. The Kamishiro fault of the Itoigawa-Shizuoka Tectonic Line (ISTL) active fault system generated a Mw 6.2 earthquake in 2014. A paleoseismic trench excavation across the 2014 surface rupture showed the evidence for the 2014 event and two prior paleoearthquakes. The slip of the penultimate earthquake was similar to that of 2014 earthquake, and its timing was constrained to be after A.D. 1645. Judging from the timing, the damaged area, and the amount of slip, the penultimate earthquake most probably corresponds to a historical earthquake in A.D. 1714. The recurrence interval of the two most recent earthquakes is thus extremely short compared with intervals on other active faults known globally. Furthermore, the slip repetition during the last three earthquakes is in accordance with the time-predictable recurrence model rather than the characteristic earthquake model. In addition, the spatial extent of the 2014 surface rupture accords with the distribution of a serpentinite block, suggesting that the relatively low coefficient of friction may account for the unusually frequent earthquakes. These findings would affect long-term forecast of earthquake probability and seismic hazard assessment on active faults.

  4. Diurnal Cycle of Convective Instability around the Central Mountains in Japan during the Warm Season.

    Science.gov (United States)

    Sato, Tomonori; Kimura, Fujio

    2005-05-01

    Convective rainfall often shows a clear diurnal cycle. The nighttime peak of convective activity prevails in various regions near the world's mountains. The influence of the water vapor and convective instability upon nocturnal precipitation is investigated using a numerical model and observed data. Recent developments in GPS meteorology allow the estimation of precipitable water vapor (PWV) with a high temporal resolution. A dense network has been established in Japan. The GPS analysis in August 2000 provides the following results: In the early evening, a high-GPS-PWV region forms over mountainous areas because of the convergence of low-level moisture, which gradually propagates toward the adjacent plain before midnight. A region of convection propagates simultaneously eastward into the plain. The precipitating frequency correlates fairly well with the GPS-PWV and attains a maximum value at night over the plain. The model also provides similar characteristics in the diurnal cycles of rainfall and high PWV. Abundant moisture accumulates over the mountainous areas in the afternoon and then advects continuously toward the plain by the ambient wind. The specific humidity greatly increases at about the 800-hPa level over the plain at night, and the PWV reaches its nocturnal maximum. The increase in the specific humidity causes an increase of equivalent potential temperature at about the 800-hPa level; as a result, the convective instability index becomes more unstable over the plain at night. These findings are consistent with the diurnal cycle of the observed precipitating frequency.

  5. Estimation of Secondary Compounds Concentrations Contributed by Biogenic VOC With Chemical Transport Model in the Central Area of Japan

    Science.gov (United States)

    Yamamoto, K.; Kanemaru, A.; Okumura, M.; Tohno, S.

    2008-12-01

    Biogenic VOC (BVOC) has comparably large contribution to generation of secondary air pollutants, such as photochemical oxidant or urban aerosol. In this study a BVOC emission inventory in the Kansai area, which is located in the central part of Japan, based on the field observation was developed. Some validations of the inventory were conducted by estimating the concentration distribution of oxidants with this developed and an existing BVOC emission inventory in Kansai area by meteorological model MM5 and atmospheric chemical transport model CMAQ. In the development of BVOC emission, the vegetation map by the Biodiversity Center of Japan which had been arranged as basic information on natural environmental preservation in a regional standard mesh (the third mesh) in 1999 was used. In this study isoprene and the mono-terpene were taken up as BVOC. Quercus crispula and Quercus serrata were selected as the source of isoprene, and Cryptomeria japonica, Chamaecyparis obtuse, Quercus phillyraeoides, Pinus densiflora, and Pinus thunbergii were selected as sources of mono-terpene. The parameter of the basic emission rate included in the model was decided by arranging the result of the observation in Kansai Research Center of Forestry and Forest Products Research Institute in each season. This emission flux from each species were calculated by G93 model by Guenther et al. and meteorological fields for the model, such as temperatures and sunlight intensities, were renewed hour by hour, therefore, this emission inventory has a high time resolution according to the season and time. In calculating meteorological fields, meteorological model MM5 Ver.3.7 was conducted in Japanese standard mesh in the selected five days of April, July, and October in 2004, and January 2005 respectively, and taking out the result of wind velocities and temperatures for substituting to the G93 model. Then atmospheric chemical transport model CMAQ Ver.4.6 with the emission inventories and

  6. Immediate behavioural responses to earthquakes in Christchurch, New Zealand, and Hitachi, Japan.

    Science.gov (United States)

    Lindell, Michael K; Prater, Carla S; Wu, Hao Che; Huang, Shih-Kai; Johnston, David M; Becker, Julia S; Shiroshita, Hideyuki

    2016-01-01

    This study examines people's immediate responses to earthquakes in Christchurch, New Zealand, and Hitachi, Japan. Data collected from 257 respondents in Christchurch and 332 respondents in Hitachi revealed notable similarities between the two cities in people's emotional reactions, risk perceptions, and immediate protective actions during the events. Respondents' physical, household, and social contexts were quite similar, but Hitachi residents reported somewhat higher levels of emotional reaction and risk perception than did Christchurch residents. Contrary to the recommendations of emergency officials, the most frequent response of residents in both cities was to freeze. Christchurch residents were more likely than Hitachi residents to drop to the ground and take cover, whereas Hitachi residents were more likely than Christchurch residents to evacuate immediately the building in which they were situated. There were relatively small correlations between immediate behavioural responses and demographic characteristics, earthquake experience, and physical, social, or household context. © 2016 The Author(s). Disasters © Overseas Development Institute, 2016.

  7. Hypercoagulability in response to elevated body temperature and central hypovolemia

    DEFF Research Database (Denmark)

    Meyer, Martin; Ostrowski, Sisse R; Overgaard, Flemming Anders;

    2013-01-01

    Coagulation abnormalities contribute to poor outcomes in critically ill patients. In trauma patients exposed to a hot environment, a systemic inflammatory response syndrome, elevated body temperature, and reduced central blood volume occur in parallel with changes in hemostasis and endothelial...... damage. The objective of this study was to evaluate whether experimentally elevated body temperature and reduced central blood volume (CBV) per se affects hemostasis and endothelial activation....

  8. Numerical modeling of the three-layered hydrothermal system in the Kuju volcanic region, central Kyushu, Japan

    Science.gov (United States)

    Araragi, K.; Ehara, S.; Fujimitsu, Y.

    2008-12-01

    Numerical modeling of hydrothermal systems beneath active volcanoes has been conducted. Their purposes were, however, confined to interpret individual geothermal systems. We constructed a numerical model of the Kuju volcanic region, central Kyushu, Japan using 3-D finite-difference code HYDROTHERM ver.2.2 (Hayba and Ingebritsen, 1994). The central part of Kuju volcano is categorized as an active magmatic hydrothermal system. Otake-Hatchobaru geothermal area, where two geothermal power plants are in operation, is known as a typical liquid dominated hydrothermal system. These two types of geothermal systems are closely located in the region. Moreover, subsurface horizontal temperature distributions in the Kuju volcanic region consist of a three-layered structure. A horizontal temperature anomaly at a depth of -2000m separates into two anomalies at depths of about 0m. Five anomalies appear in the horizontal temperature distribution of 80m depth. Geothermal systems or such characteristics of the thermal structure should be related to the influence of the magma chamber in the region. Existence of molten magma was suggested from seismic observations (Yoshikawa et al., 2005). Therefore, we presumed that the geothermal systems in Otake- Hatchobaru geothermal area and in the central part of Kuju volcano can be explained by a common magma chamber. We determined the calculation time as 40000 based on the age of the latest large pyroclastic flow deposit (Kamata, 1997). The temperature of the magma chamber in the model was maintained at a constant value during the calculation. Parameter studies of crustal permeabilities were conducted to reproduce temperature profiles obtained by logging at shallow depths (NEDO, 1987). The calculated results show that temperature anomalies in the basement rock seemed to be directly affected by the magma chamber. The results also indicate that molten materials have been continuously supplied from the bottom of the magma chamber of Kuju volcano

  9. Georesistivity structure in the central part of North-Eastern Japan Arc; Tohoku chiho chubu chiiki no denki dendodo kozo

    Energy Technology Data Exchange (ETDEWEB)

    Fujinawa, Y. [National Research Institute for Disaster Prevention, Tsukuba (Japan); Kawakami, N. [GERD Geothermal Energy Research and Development Co. Ltd., Tokyo (Japan); Ueshima, M. [The University of Tokyo, Tokyo (Japan). Earthquake Research Institute; Honkura, Y. [Tokyo Institute of Technology, Tokyo (Japan)

    1998-03-13

    MT measurement of transects was made in the central part of North-Eastern Japan Arc to clarify tectonics of subduction zones. 1-D, 2-D and 3-D resistivity structures are observed in surface layers, and zones shallower and deeper than a Conrad surface, respectively. A main structure direction is S-N or NNE-SSW. Ishinomaki-Chokai tectonic line and low- resistivity zones due to Quaternary volcanos (Naruko, Onikobe) exist in a backbone range region. Resistivity is 100{Omega}{center_dot}m or less by Bostick Inversion except Mesozoic and Palaeozoic layers in the southern Kitakami mountainous region, resulting in a good agreement with previous results in a north transect. Resistivity is several {Omega}{center_dot}m and depth is several km around Shinjo basin and in surface layers of Kitakami River region. The backbone range region shows complex resistivity structures because of volcanic activity and wide-area hot water activity. High-resistivity layers correspond to stable Mesozoic and Palaeozoic land layers. Seismic velocity increases in the low-resistivity zone. Earthquake generally occurs at the boundary between resistivity structures. 68 refs., 9 figs., 2 tabs.

  10. Continuity of subsurface fault structure revealed by gravity anomaly: the eastern boundary fault zone of the Niigata plain, central Japan

    Science.gov (United States)

    Wada, Shigeki; Sawada, Akihiro; Hiramatsu, Yoshihiro; Matsumoto, Nayuta; Okada, Shinsuke; Tanaka, Toshiyuki; Honda, Ryo

    2017-01-01

    We have investigated gravity anomalies around the Niigata plain, which is a sedimentary basin in central Japan bounded by mountains, to examine the continuity of subsurface fault structures of a large fault zone—the eastern boundary fault zone of the Niigata plain (EBFZNP). The features of the Bouguer anomaly and its first horizontal and vertical derivatives clearly illustrate the EBFZNP. The steep first horizontal derivative and the zero isoline of the vertical derivative are clearly recognized along the entire EBFZNP over an area that shows no surface topographic features of an active fault. Two-dimensional density structure analyses also confirm a relationship between the two first derivatives and the subsurface fault structure. Therefore, we conclude that the length of the EBFZNP as an active fault extends to 56 km, which is longer than previously estimated. This length leads to an estimation of a moment magnitude of 7.4 of an expected earthquake from the EBFZNP.[Figure not available: see fulltext.

  11. Effects of silviculture treatments in a hurricane-damaged forest on car- bon storage and emissions in central Hokkaido, Japan

    Institute of Scientific and Technical Information of China (English)

    Toshiaki Owari; Naoto Kamata; Takeshi Tange; Mikio Kaji; Akio Shimomura

    2011-01-01

    Hurricanes cause abrupt carbon reduction in forests, but silviculture treatment can be an effective means of quickly regenerating and restoring hurricane-damaged sites. This study assessed how silviculture treatments affect carbon balance after hurricane damage in central Hokkaido, Japan. We examined carbon storage in trees and underground vegetation as well as carbon emissions from silviculture operations in 25year-old stands, where scarification and plantation occurred just after hurricane damage. The amount of carbon stored varied according to silviculture treatment. Among three scarification treatments, a scarified depth of 0 cm (understory vegetation removal) led to the largest amount of carbon stored (64.7 t·ha 1 C). Among four plantation treatments, the largest amount of carbon was stored in a Larix hybrid (L. gmelinii var. japonica × L. kaempferi) plantation (80.3 t·ha-1 C). The plantation of Abies sachalinensis was not successful at accumulating carbon (40.5·ha-1 C). The amount of carbon emitted from silviculture operations was 0.050.14 t·ha 1 C, and it marginally affected the net carbon balance of the silviculture project. Results indicate that silviculture treatments should be performed in an appropriate way to effectively recover the ability of carbon sequestration in hurricane-damaged forests.

  12. Lonestones as indicators of tsunami deposits in deep-sea sedimentary rocks of the Miocene Morozaki Group, central Japan

    Science.gov (United States)

    Tachibana, Toru

    2013-05-01

    Lonestones are isolated larger clasts enclosed in muddy fine-grained deposits, and are usually interpreted as iceberg-rafted dropstones. This interpretation implies the existence of glaciers (continental ice sheets) and, consequently, a cool climate. However, alternative interpretations are possible, as lonestones may also be deposited by non-glacial processes. Therefore, clarification of the depositional processes associated with lonestones is fundamental for studies based on lonestone-bearing deposits. A field survey of lonestone-bearing deposits from Early Miocene deep-sea sedimentary rocks found around the Chita Peninsula of central Japan suggests that tsunami-induced flows on the sea bottom may also form lonestones. These lonestones are associated with sandy to gravelly deposits, and were deposited by high-energy episodic currents. The main features of these deposits are the multiple stacking of normally graded units, and the laterally discontinuous distribution of coarse-grained clastic material (sands and gravels). Such features are consistent with deposition by tsunamis and suggest that lonestone-bearing depositional successions must be carefully interpreted, especially where lonestones are used as glacial indicators, as some lonestones were probably put in place by ancient tsunami events.

  13. Plutonium concentration and isotopic ratio in soil samples from central-eastern Japan collected around the 1970s

    Science.gov (United States)

    Yang, Guosheng; Zheng, Jian; Tagami, Keiko; Uchida, Shigeo

    2015-04-01

    Obtaining Pu background data in the environment is essential for contamination source identification and assessment of environmental impact of Pu released from the Fukushima Daiichi nuclear power plant (FDNPP) accident. However, no baseline information on Pu isotopes in Fukushima Prefecture has been reported. Here we analyzed 80 surface soil samples collected from the central-eastern Japan during 1969-1977 for 239+240Pu activity concentration and 240Pu/239Pu atom ratio to establish the baseline before the FDNPP accident. We found that 239+240Pu activity concentrations ranged from 0.004 -1.46 mBq g-1, and 240Pu/239Pu atom ratios varied narrowly from 0.148 to 0.229 with a mean of 0.186 +/- 0.015. We also reconstructed the surface deposition density of 241Pu using the 241Pu/239Pu atom ratio in the Japanese fallout reference material. The obtained results indicated that, for the FDNPP-accident released 241Pu, a similar radiation impact can be estimated as was seen for the global fallout deposited 241Pu in the last decades.

  14. Innate immune responses in central nervous system inflammation

    DEFF Research Database (Denmark)

    Finsen, Bente; Owens, Trevor

    2011-01-01

    In autoimmune diseases of the central nervous system (CNS), innate glial cell responses play a key role in determining the outcome of leukocyte infiltration. Access of leukocytes is controlled via complex interactions with glial components of the blood-brain barrier that include angiotensin II...

  15. Magnetic Surveys for Mapping of Ultramafic Bodies on the Site of the Ohi Nuclear Power Station, Central Japan

    Science.gov (United States)

    Okuma, S.; Makino, M.; Miyakawa, A.; Nakatsuka, T.; Iwamori, A.; Tanaka, Y.; Kudo, S.; Yanagida, M.; Sasaki, T.; Sugimori, T.; Kitao, H.; Asahi, N.; Shiomi, T.; Higashida, Y.

    2016-12-01

    The Ohi nuclear power station is located at the northern Oshima Peninsula in the Wakasa Bay on the coast of Japan Sea, central Japan. The geology of the site of the power station is composed mainly of shales, diabases, gabbros and ultramafic rocks of the Paleozoic Yakuno Ophiolite. An evaluation of the power station on conformity to the new regulatory requirements for nuclear power plants has been conducted. Various surveys such as tectonic geomorphological, trenching and drilling were conducted to better understand the fracture zones in the gabbro and ultramafic complex. As a result, the fracture zones can be classified into two types: faults found only in the complex and landslides seen in the upper parts of the ultramafic bodies. Whereas, magnetic susceptibilities were measured for whole cores from drilling and the upper parts of the ultramafic bodies showed high magnetic susceptibilities (> 10-2 SI). To map the distribution of ultramafic bodies, we conducted magnetic surveys on ground and at sea around Daibahama beach in December 2015. A ground magnetic survey was carried out on a grid and along a specified line on a small peninsula and some reeves by using a proton magnetometer. A seaborne magnetic survey was also conducted by a small rubber boat on which a Cesium magnetometer was mounted. Both observed data were merged and an IGRF residual magnetic anomaly map was compiled. According to the map, several positive magnetic anomalies lie over the southeastern edge of the estimated distribution area of ultramafic bodies on land, while negative magnetic anomalies are dominant at the northwestern edge. Magnetic susceptibility and NRM measurements were carried out for columnar specimens sampled from drill cores. As a preliminary analysis, we conducted 2D modeling of the specific survey line on a basis of the rock magnetic measurements. A thin dipping-dike with a reverse magnetization can account for the observed magnetic anomalies. However there still remain

  16. Determination of temporal changes in seismic velocity caused by volcanic activity in and around Hakone volcano, central Japan, using ambient seismic noise records

    Science.gov (United States)

    Yukutake, Yohei; Ueno, Tomotake; Miyaoka, Kazuki

    2016-12-01

    Autocorrelation functions (ACFs) for ambient seismic noise are considered to be useful tools for estimating temporal changes in the subsurface structure. Velocity changes at Hakone volcano in central Japan, where remarkable swarm activity has often been observed, were investigated in this study. Significant velocity changes were detected during two seismic activities in 2011 and 2013. The 2011 activity began immediately after the 2011 Tohoku-oki earthquake, suggesting remote triggering by the dynamic stress changes resulting from the earthquake. During the 2013 activity, which exhibited swarm-like features, crustal deformations were detected by Global Navigation Satellite System (GNSS) stations and tiltmeters, suggesting a pressure increment of a Mogi point source at a depth of 7 km and two shallow open cracks. Waveforms that were bandpass-filtered between 1 and 3 Hz were used to calculate ACFs using a one-bit correlation technique. Fluctuations in the velocity structure were obtained using the stretching method. A gradual decrease in the velocity structure was observed prior to the 2013 activity at the KOM station near the central cone of the caldera, which started after the onset of crustal expansion observed by the GNSS stations. Additionally, a sudden significant velocity decrease was observed at the OWD station near a fumarolic area just after the onset of the 2013 activity and the tilt changes. The changes in the stress and strain caused by the deformation sources were likely the main contributors to these decreases in velocity. The precursory velocity reduction at the KOM station likely resulted from the inflation of the deep Mogi source, whereas the sudden velocity decrease at the OWD station may reflect changes in the strain caused by the shallow open-crack source. Rapid velocity decreases were also detected at many stations in and around the volcano after the 2011 Tohoku-oki earthquake. The velocity changes may reflect the redistribution of hydrothermal

  17. Medical response to the Great East Japan Earthquake in Ishinomaki City

    Directory of Open Access Journals (Sweden)

    Tadashi Ishii

    2011-12-01

    Full Text Available Problem: The Ishinomaki Red Cross Hospital is the only designated disaster hospital in the Ishinomaki Medical Zone, Japan that was undamaged from the Great East Japan Earthquake in March 2011. The tsunami completely destroyed a large part of the Ishinomaki Medical Zone.Context: The Ishinomaki Red Cross Hospital was designed with the capability to respond to disasters. An instruction manual for responding to disasters had been developed and was exercised through drills. Action: In accordance with the manual, the hospital disaster task force was established. The Ishinomaki Zone Joint Relief Team coordinated medical support from organizations such as physicians associations, dental associations, self-defence forces medical teams, pharmacists associations, the Japanese Red Cross and relief teams from hospitals all over the country. In three days, the joint relief team directly visited all emergency shelters to make an initial assessment and to collect information about the number and state of health of evacuees, provision of food and drinking water and the availability of electricity, water and sewerage. Outcome: Initial assessment revealed that 35 emergency shelters lacked a sufficient food supply and that 100 shelters had unsanitary conditions. The joint relief team provided the Miyagi Prefecture government and the Ishinomaki municipal government with information about emergency shelters that did not have a sufficient food supply. As of 30 September, the activities of the joint relief teams were completed, and there was no outbreak of communicable diseases in the Ishinomaki Medical Zone. A total of 328 shelters with 46 480 evacuees were managed by the Ishinomaki Zone Joint Relief Team.Discussion: Advanced preparation to quickly establish an initial response system, expertise, and decision-making ability and the ability to get things done are required for disaster response management.

  18. Estimation of total discharged mass from the phreatic eruption of Ontake Volcano, central Japan, on September 27, 2014

    Science.gov (United States)

    Takarada, Shinji; Oikawa, Teruki; Furukawa, Ryuta; Hoshizumi, Hideo; Itoh, Jun'ichi; Geshi, Nobuo; Miyagi, Isoji

    2016-08-01

    The total mass discharged by the phreatic eruption of Ontake Volcano, central Japan, on September 27, 2014, was estimated using several methods. The estimated discharged mass was 1.2 × 106 t (segment integration method), 8.9 × 105 t (Pyle's exponential method), and varied from 8.6 × 103 to 2.5 × 106 t (Hayakawa's single isopach method). The segment integration and Pyle's exponential methods gave similar values. The single isopach method, however, gave a wide range of results depending on which contour was used. Therefore, the total discharged mass of the 2014 eruption is estimated at between 8.9 × 105 and 1.2 × 106 t. More than 90 % of the total mass accumulated within the proximal area. This shows how important it is to include a proximal area field survey for the total mass estimation of phreatic eruptions. A detailed isopleth mass distribution map was prepared covering as far as 85 km from the source. The main ash-fall dispersal was ENE in the proximal and medial areas and E in the distal area. The secondary distribution lobes also extended to the S and NW proximally, reflecting the effects of elutriation ash and surge deposits from pyroclastic density currents during the phreatic eruption. The total discharged mass of the 1979 phreatic eruption was also calculated for comparison. The resulting volume of 1.9 × 106 t (using the segment integration method) indicates that it was about 1.6-2.1 times larger than the 2014 eruption. The estimated average discharged mass flux rate of the 2014 eruption was 1.7 × 108 kg/h and for the 1979 eruption was 1.0 × 108 kg/h. One of the possible reasons for the higher flux rate of the 2014 eruption is the occurrence of pyroclastic density currents at the summit area.

  19. Distribution and community structure of fish in Obitsu-gawa River Estuary of inner Tokyo Bay, central Japan

    Directory of Open Access Journals (Sweden)

    Joeppette J. Hermosilla

    2012-09-01

    Full Text Available The distribution and community structure of fish in Obitsu-gawa River Estuary of inner TokyoBay, central Japan was studied from May to December 2005 and March to April 2006. A total of 19,006individuals, represented by 25 species and some unidentified species under family Clupeidae, Cyprinidae,Gobiidae, Hemiramphidae, Mugilidae, Platycephidae, Pleuronectidae and Triglidae were collected. FamilyGobiidae had the most number of taxa with 13 genera and 10 species. Greatest fish abundancehappened in August and secondarily in April and May. Species richness was evident in the warmermonths particularly in May (17 taxa, August (21 taxa, September (15 taxa and October (17 taxa.Marine teleosts significantly contributed to the species richness and abundance of fish, whichcorresponded to 52.9% (10,046 individuals of the total catch while the estuarine fishes were the secondmost abundant group with 33.5% (6,372 individuals of the total catch. Species dominance was acoherent feature of this community. The proportional contribution of marine teleosts to the fishcommunity decreased with increase distance upstream while that of estuarine fishes increased withincrease distance upstream. The developmental stages of gobies range from larvae to adult but juvenilesconstitute 77.06% of the total sample. The distribution of developmental stage of estuarine gobies wasinfluenced to a greater extent by variation in monthly water temperature and station or the interaction ofboth. Adult estuarine gobies had the tendency to aggregate in the middle estuary reflecting their hightolerance to a wide range of water salinity inherent in this station but avoided the lower estuary mostlikely due to the predominance of high salinity waters.

  20. Sedimentary environment and paleosols of middle Miocene fluvial and lacustrine sediments in central Japan: Implications for paleoclimate interpretations

    Science.gov (United States)

    Hatano, Nozomi; Yoshida, Kohki

    2017-01-01

    Sedimentary facies analysis and description of paleosols were carried out for the middle Miocene Tokiguchi Porcelain Clay Formation (PCF) in central Japan in order to interpret the soil-forming environments during a long hiatus in the Japanese Islands. The sedimentary facies suggests that deposition occurred mainly in a lacustrine environment, with minor channel-fill and debris-flow deposits associated with alluvial fan environments. The coarse-grained sediments, which are inferred to have been deposited in channel-bar and debris-flow deposits, are present only in the marginal area of the sedimentary basin. Mature paleosols are identified in the Tokiguchi PCF, characterized by illuviated clay, identifiable soil horizons including Bt horizons and many in situ plant fossils, and are then similar to Ultisols. Most tree trunk fossils, however, were preserved by burial beneath debris-flow deposits. Most of paleosols formed on lacustrine deposits and were covered by lacustrine clay and silt deposits, without intervening coarse-grained deposits, such as flood-flow deposits. This change of sedimentary facies indicates a dramatic change of hydrologic environment, from stagnant water to entirely desiccated conditions, promoting weathering and soil formation. The relationship between sedimentary facies and Pedotypes, consequently, implies the repetition of specific events, i.e., submergence and emergence of lake bottom, most likely due to formation and drainage of a dammed lake. These isolated events and development of mature paleosols might suggest specific characteristics of middle Miocene weathering conditions, such as seasonally heavy rainfall and/or warm climatic conditions in the Japanese Islands.

  1. An Attempt at Captive Breeding of the Endangered Newt Echinotriton andersoni, from the Central Ryukyus in Japan.

    Science.gov (United States)

    Igawa, Takeshi; Sugawara, Hirotaka; Tado, Miyuki; Nishitani, Takuma; Kurabayashi, Atsushi; Islam, Mohammed Mafizul; Oumi, Shohei; Katsuren, Seiki; Fujii, Tamotsu; Sumida, Masayuki

    2013-07-31

    Anderson's crocodile newt (Echinotriton andersoni) is distributed in the Central Ryukyu Islands of southern Japan, but environmental degradation and illegal collection over the last several decades have devastated the local populations. It has therefore been listed as a class B1 endangered species in the IUCN Red List, indicating that it is at high risk of extinction in the wild. The species is also protected by law in both Okinawa and Kagoshima prefectures. An artificial insemination technique using hormonal injections could not be applied to the breeding of this species in the laboratory. In this study we naturally bred the species, and tested a laboratory farming technique using several male and female E. andersoni pairs collected from Okinawa, Amami, and Tokunoshima Islands and subsequently maintained in near-biotopic breeding cages. Among 378 eggs derived from 17 females, 319 (84.4%) became normal tailbud embryos, 274 (72.5%) hatched normally, 213 (56.3%) metamorphosed normally, and 141 (37.3%) became normal two-month-old newts; in addition, 77 one- to three-year-old Tokunoshima newts and 32 Amami larvae are currently still growing normally. Over the last five breeding seasons, eggs were laid in-cage on slopes near the waterfront. Larvae were raised in nets maintained in a temperature-controlled water bath at 20 °C and fed live Tubifex. Metamorphosed newts were transferred to plastic containers containing wet sponges kept in a temperature-controlled incubator at 22.5 °C and fed a cricket diet to promote healthy growth. This is the first published report of successfully propagating an endangered species by using breeding cages in a laboratory setting for captive breeding. Our findings on the natural breeding and raising of larvae and adults are useful in breeding this endangered species and can be applied to the preservation of other similarly wild and endangered species such as E. chinhaiensis.

  2. The efficacy of support vector machines (SVM) in robust determination of earthquake early warning magnitudes in central Japan

    Indian Academy of Sciences (India)

    Ramakrushna Reddy; Rajesh R Nair

    2013-10-01

    This work deals with a methodology applied to seismic early warning systems which are designed to provide real-time estimation of the magnitude of an event. We will reappraise the work of Simons et al. (2006), who on the basis of wavelet approach predicted a magnitude error of ±1. We will verify and improve upon the methodology of Simons et al. (2006) by applying an SVM statistical learning machine on the time-scale wavelet decomposition methods. We used the data of 108 events in central Japan with magnitude ranging from 3 to 7.4 recorded at KiK-net network stations, for a source–receiver distance of up to 150 km during the period 1998–2011. We applied a wavelet transform on the seismogram data and calculating scale-dependent threshold wavelet coefficients. These coefficients were then classified into low magnitude and high magnitude events by constructing a maximum margin hyperplane between the two classes, which forms the essence of SVMs. Further, the classified events from both the classes were picked up and linear regressions were plotted to determine the relationship between wavelet coefficient magnitude and earthquake magnitude, which in turn helped us to estimate the earthquake magnitude of an event given its threshold wavelet coefficient. At wavelet scale number 7, we predicted the earthquake magnitude of an event within 2.7 seconds. This means that a magnitude determination is available within 2.7 s after the initial onset of the P-wave. These results shed light on the application of SVM as a way to choose the optimal regression function to estimate the magnitude from a few seconds of an incoming seismogram. This would improve the approaches from Simons et al. (2006) which use an average of the two regression functions to estimate the magnitude.

  3. An Attempt at Captive Breeding of the Endangered Newt Echinotriton andersoni, from the Central Ryukyus in Japan

    Directory of Open Access Journals (Sweden)

    Masayuki Sumida

    2013-07-01

    Full Text Available Anderson’s crocodile newt (Echinotriton andersoni is distributed in the Central Ryukyu Islands of southern Japan, but environmental degradation and illegal collection over the last several decades have devastated the local populations. It has therefore been listed as a class B1 endangered species in the IUCN Red List, indicating that it is at high risk of extinction in the wild. The species is also protected by law in both Okinawa and Kagoshima prefectures. An artificial insemination technique using hormonal injections could not be applied to the breeding of this species in the laboratory. In this study we naturally bred the species, and tested a laboratory farming technique using several male and female E. andersoni pairs collected from Okinawa, Amami, and Tokunoshima Islands and subsequently maintained in near-biotopic breeding cages. Among 378 eggs derived from 17 females, 319 (84.4% became normal tailbud embryos, 274 (72.5% hatched normally, 213 (56.3% metamorphosed normally, and 141 (37.3% became normal two-month-old newts; in addition, 77 one- to three-year-old Tokunoshima newts and 32 Amami larvae are currently still growing normally. Over the last five breeding seasons, eggs were laid in-cage on slopes near the waterfront. Larvae were raised in nets maintained in a temperature-controlled water bath at 20 °C and fed live Tubifex. Metamorphosed newts were transferred to plastic containers containing wet sponges kept in a temperature-controlled incubator at 22.5 °C and fed a cricket diet to promote healthy growth. This is the first published report of successfully propagating an endangered species by using breeding cages in a laboratory setting for captive breeding. Our findings on the natural breeding and raising of larvae and adults are useful in breeding this endangered species and can be applied to the preservation of other similarly wild and endangered species such as E. chinhaiensis.

  4. Visit of Mr. Susumu Yoda, Japanese Atomic Energy Commission, Mr. Nobuo Natsume, Vice-President, Central Research Institute of Electric Power Industry, Japan (CRIEPI), Mr. Nobuya Yoshiki, CRIEPI, Mrs. Seiko Ichikawa, Interpreter, with Mr. Taylor of CERN, visiting SM18

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Visit of Mr. Susumu Yoda, Japanese Atomic Energy Commission, Mr. Nobuo Natsume, Vice-President, Central Research Institute of Electric Power Industry, Japan (CRIEPI), Mr. Nobuya Yoshiki, CRIEPI, Mrs. Seiko Ichikawa, Interpreter, with Mr. Taylor of CERN, visiting SM18

  5. Analysis of the interdecadal variability of summer precipitation in central Japan using a reconstructed 106 year long oxygen isotope record from tree ring cellulose

    Science.gov (United States)

    Kurita, Naoyuki; Nakatsuka, Takeshi; Ohnishi, Keiko; Mitsutani, Takumi; Kumagai, Tomo'omi

    2016-10-01

    We present a unique proxy for reconstructing the interannual variability of summer precipitation associated with the quasi-stationary front (Baiu front) in central Japan. The rainfall from the Baiu front has a relatively lower oxygen isotopic composition than other types of nonfrontal precipitation. The variability in the oxygen isotopes in summer rainfall is closely related to the Baiu frontal activity. In this study we used a mechanistic tree ring isotope model to reconstruct a 106 year long oxygen isotopic composition of precipitation during the early rainy season (June) based on the oxygen isotopic compositions of the annual rings of Chamaecyparis obtusa Endl trees from central Japan. The year-to-year variations of the isotopes over the most recent 25 years are associated with several teleconnection patterns that often lead to the Baiu precipitation anomalies in central Japan (such as the Pacific-Japan (PJ) pattern, Silk Road pattern, and wave train pattern along the polar jet). Yet none of these external forcing mechanisms apply further back in time. From the 1950s to 1980s, the interannual isotopic variability is predominantly related to local factors such as anomalous intensification/weakening of the Bonin High. Before the 1950s, the variability of the oxygen isotopic composition of precipitation is mainly associated with a wave train pattern along the polar jet. The isotopic variability is predominantly linked to the PJ pattern, while the PJ index is correlated with El Niño-Southern Oscillation. These findings suggest that the teleconnection patterns influencing Baiu precipitation variability vary according to interdecadal time scales during the twentieth century.

  6. Immune response induction in the central nervous system

    DEFF Research Database (Denmark)

    Owens, Trevor; Babcock, Alicia

    2002-01-01

    The primary function of the immune response is protection of the host against infection with pathogens, including viruses. Since viruses can infect any tissue of the body, including the central nervous system (CNS), it is logical that cells of the immune system should equally have access to all...... tissues. Nevertheless, the brain and spinal cord are noted for their lack of immune presence. Relative to other organ systems, the CNS appears immunologically privileged. Furthermore, when immune responses do occur in the CNS, they are frequently associated with deleterious effects such as inflammatory...

  7. Molecular characterization of phenylketonuria and tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Japan.

    Science.gov (United States)

    Okano, Yoshiyuki; Kudo, Satoshi; Nishi, Yasuaki; Sakaguchi, Tomoko; Aso, Kazuyoshi

    2011-04-01

    Phenylketonuria (PKU) is a heterogeneous metabolic disorder caused by a deficiency in hepatic phenylalanine hydroxylase (PAH). On the basis of phenotype/genotype correlations, determination of phenylketonuric genotype is important for classification of the clinical phenotype and treatment of PKU, including tetrahydrobiopterin therapy. We characterized the genotypes of 203 Japanese patients with PKU and hyperphenylalaninemia using the following systems: (1) denaturing high-performance liquid chromatography with a GC-clamped primer; (2) direct sequencing; and, (3) multiplex ligation-dependent probe amplification. Of 406 mutant alleles, 390 (96%) were genotyped; 65 mutations were identified, including 22 new mutations. R413P, R241C, IVS4-1g>a, R111X and R243Q were prevalent mutations. Mutations prevalent in the Japanese cohort are also common in Korean and Northern Chinese populations, suggesting same origin. The spectrum of prevalent mutations was not significantly different among six Japanese districts, indicating that Japan comprises a relatively homogeneous ethnic group. We classified the mutations by clinical phenotypes and in vivo PAH activity and estimated the mutations with potential tetrahydrobiopterin (BH(4)) responsiveness. The frequency of BH(4) responsiveness based on the genotype was 29.1% in Japanese PKU patients. A catalog of PKU genotypes would be useful for predicting clinical phenotype, deciding on the subsequent treatment of PKU including BH(4) therapy, and genetic counseling in East Asia.

  8. Involvement of central alpha1-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenaline.

    Science.gov (United States)

    de Andrade, Carina A F; de Andrade, Glaucia M F; De Paula, Patricia M; De Luca, Laurival A; Menani, José V

    2009-04-01

    Moxonidine (alpha2-adrenoceptor/imidazoline receptor agonist) injected into the lateral ventricle induces diuresis, natriuresis and renal vasodilation. Moxonidine-induced diuresis and natriuresis depend on central imidazoline receptors, while central alpha1-adrenoceptors are involved in renal vasodilation. However, the involvement of central alpha1-adrenoceptors on diuresis and natriuresis to central moxonidine was not investigated yet. In the present study, the effects of moxonidine, alpha-methylnoradrenaline (alpha2-adrenoceptor agonist) or phenylephrine (alpha1-adrenoceptor agonist) alone or combined with previous injections of prazosin (alpha1-adrenoceptor antagonist), yohimbine or RX 821002 (alpha2-adrenoceptor antagonists) intracerebroventricularly (i.c.v.) on urinary sodium, potassium and volume were investigated. Male Holtzman rats (n = 5-18/group) with stainless steel cannula implanted into the lateral ventricle and submitted to gastric water load (10% of body weight) were used. Injections of moxonidine (20 nmol) or alpha-methylnoradrenaline (80 nmol) i.c.v. induced natriuresis (196 +/- 25 and 171 +/- 30, respectively, vs. vehicle: 101 +/- 9 microEq/2 h) and diuresis (9.0 +/- 0.4 and 12.3 +/- 1.6, respectively, vs. vehicle: 5.2 +/- 0.5 ml/2 h). Pre-treatment with prazosin (320 nmol) i.c.v. abolished the natriuresis (23 +/- 4 and 76 +/- 11 microEq/2 h, respectively) and diuresis (5 +/- 1 and 7.6 +/- 0.8 ml/2 h, respectively) produced by i.c.v. moxonidine or alpha-methylnoradrenaline. RX 821002 (320 nmol) i.c.v. abolished the natriuretic effect of alpha-methylnoradrenaline, however, yohimbine (320 nmol) did not change renal responses to moxonidine. Phenylephrine (80 nmol) i.c.v. induced natriuresis and kaliuresis that were blocked by prazosin. Therefore, the present data suggest that moxonidine and alpha-methylnoradrenaline acting on central imidazoline receptors and alpha2-adrenoceptors, respectively, activate central alpha1-adrenergic mechanisms to

  9. Reconstruction of early spring temperature for central Japan from the tree-ring widths of Hinoki cypress and its verification by other proxy records

    Science.gov (United States)

    Yonenobu, Hitoshi; Eckstein, Dieter

    2006-05-01

    We describe the results of a dendroclimatic study in central Japan using ring width data from living trees of Hinoki cypress. February-April temperatures were reconstructed for the period AD 1719-1961. This reconstruction, from which five cooling events were determined for the late Little Ice Age, was validated against other climate proxies. There is a reasonable agreement with cold periods previously estimated from documentary records in Japan and China. A notably good agreement is also found for a dendroclimatic reconstruction for Korea, suggesting that the annual activity of the winter monsoon in the western Pacific Rim persisted longer in the 19th century than at present. Records of prolonged famines and unusual climatic phenomena support the reconstruction of the cold periods in the 1780s, 1810s and 1830s. It is thus revealed that the Hinoki chronology has enough potential to reconstruct the climatic variability further into the past.

  10. Seasonally and diurnally different response of surface air temperature to historical urbanization in Sapporo, North Japan

    Science.gov (United States)

    Sato, T.; Sugimoto, S.; Sasaki, T.

    2014-12-01

    Anthropogenic landscape changes have dramatically altered near surface climate in many regions of the world. In particular, regional/local-scale land use change is attributed to the long-term change in observed surface air temperature through changes in surface radiation budget and energy partitioning. This study analyses the response of surface air temperature characteristics to the historical urbanization in Sapporo, a snowy city in North Japan. Around Sapporo, natural forest has been cleared and replaced with urban since the late 19th century. Annual mean temperature in Sapporo has increased dramatically, whose rate being approximately twice of that in the station without urbanization. The rate of temperature increase shows asymmetric feature among seasons and dependent on time of the day; a prominent warming in winter daily minimum temperature and no significant trend in summer daily maximum temperature. In order to clarify the seasonal and diurnal dependence of the response to land use change, two 27-year simulations were conducted using WRF-ARW model nudged to reanalysis data during 19872/1983 winter to 2008/2009 winter; a control run uses past land cover and a sensitivity run uses present land cover. The numerical experiments successfully replicate the observed influence of urbanization with higher temperature change in winter nights and smaller temperature change in summer days. An analysis on surface energy balance indicates the changes in Bowen ratio is a primal cause of increasing sensible heat in both summer and winter. However, atmospheric response to the elevated sensible heat flux is very different depending on boundary layer structure between winter and summer or between night and day. This mechanism could clearly explain the asymmetric temperature trend observed worldwide, especially in cold regions where nocturnal inversion develops.

  11. Present situation of cedar pollinosis in Japan and its immune responses.

    Science.gov (United States)

    Okamoto, Yoshitaka; Horiguchi, Shigetoshi; Yamamoto, Heizaburo; Yonekura, Syuji; Hanazawa, Toyoyuki

    2009-06-01

    Recent observations have suggested significant worldwide increase in the prevalence of allergic rhinitis and cedar pollinosis. In Japan, Japanese cedar (Cryptometria japonica) and Japanese cypress (Chamaecyparis obtusa) pollens are considered to be the major unique allergens and their extent of dispersal is quite large, travelling more than 100km and thus causing serious pollinosis. Cedar pollinosis is a typical type 1 allergic disease by an adaptive immune response that occurs through the induction of allergen-specific effector T cells from naïve T cells. We examined the number of Japanese cedar pollen specific memory Th cells in the peripheral blood of the patients and found that the cedar pollen specific IL-4-producing Th2 memory cells increased during the pollen season and decreased during the off-season. However, more than 60% of the cedar-specific memory Th2 cells survived up to 8 months after the pollen season. Natural killer T(NKT) cells represent a unique lymphocyte subpopulation and their activity is not restricted to MHC antigens. NKT cells play an important role in innate immunity, however, the participation in development of allergic rhinitis could not be clarified.

  12. Present Situation of Cedar Pollinosis in Japan and its Immune Responses

    Directory of Open Access Journals (Sweden)

    Yoshitaka Okamoto

    2009-01-01

    Full Text Available Recent observations have suggested significant worldwide increase in the prevalence of allergic rhinitis and cedar pollinosis. In Japan, Japanese cedar (Cryptometria japonica and Japanese cypress (Chamaecyparis obtusa pollens are considered to be the major unique allergens and their extent of dispersal is quite large, travelling more than 100 km and thus causing serious pollinosis. Cedar pollinosis is a typical type 1 allergic disease by an adaptive immune response that occurs through the induction of allergen-specific effector T cells from naive T cells. We examined the number of Japanese cedar pollen specific memory Th cells in the peripheral blood of the patients and found that the cedar pollen specific IL-4-producing Th2 memory cells increased during the pollen season and decreased during the off-season. However, more than 60% of the cedar-specific memory Th2 cells survived up to 8 months after the pollen season. Natural killer T(NKT cells represent a unique lymphocyte subpopulation and their activity is not restricted to MHC antigens. NKT cells play an important role in innate immunity, however, the participation in development of allergic rhinitis could not be clarified.

  13. Severity of pre-existing psychiatric illness and response to the Great East Japan Earthquake.

    Science.gov (United States)

    Funayama, Michitaka; Mizushima, Jin

    2013-10-01

    Reports have described how psychiatric patients respond to disasters. However, previous reports on the response depending on diagnostic categories have provided no clear consensus. Here we analyzed response to the Great East Japan Earthquake of March 11, 2011, among psychiatric patients in light of severity of pre-existing psychiatric illness. We studied psychiatric change among a population of psychiatric outpatients in Tochigi prefecture, located ~160 km (~100 miles) southeast of the Fukushima nuclear power plant, in an area that suffered moderate damage from the earthquake and radiation. A total of 294 psychiatric outpatients was assessed using the Global Assessment of Functioning (GAF-F). A change of ≥10 points in the GAF-F score was counted as a change in symptoms. The data were stratified by disease category, gender, and GAF-F score and analyzed using the Fisher's exact test. In the 2 months after the earthquake, 5.4% of patients showed evidence of a change in symptoms, with 4.1% worsening and 1.4% improving. Compared with patients having a GAF-F score ≤50, significantly more patients with a score >50 showed evidence of worsening symptoms. No significant difference was found with respect to gender or diagnostic category for patients with worsened or improved symptoms. Our findings reveal that a relatively small percent of patients with pre-existing psychiatric diseases showed evidence of a change in symptoms and that patients with mild-to-moderate psychiatric illness are potentially vulnerable to the impacts of a natural disaster. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Relatively spared central multifocal electroretinogram responses in acute quinine toxicity

    Science.gov (United States)

    Saeed, Muhammad Usman; Noonan, Carmel; Hagan, Richard; Brown, Malcolm

    2011-01-01

    A 71-year-old man was investigated with electrodiagnostic testing 4 months after a deliberate quinine overdose. Initially he was admitted to intensive care unit with visual acuity (VA) of perception of light in both eyes. VA recovered to 6/6 right eye and 6/12 left eye, though severely constricted fields were noted. Slow stimulus (base period of 83 ms) multifocal electroretinogram (ERG) showed electronegative responses outside the inner 5 degrees, with a reduced but electropositive response seen in this central area. It appears that in this case of bilaterally negative ERGs that the macula/fovea (which has a vascular supply through the choroid) is relatively spared as is seen in bilateral vascular electronegative ERGs. This may indicate that quinine toxicity to the retina may be secondary to effects similar to vascular occlusion or severe ischemia during the acute phase of quinine poisoning. PMID:22693278

  15. Contrasting response of glacierized catchments in the Central Himalaya and the Central Andes to climate change

    Science.gov (United States)

    Ragettli, Silvan; Pellicciotti, Francesca; Immerzeel, Walter

    2015-04-01

    total melt from glaciers differ fundamentally. In the Langtang region in the Central Himalaya, the model results indicate increasing catchment runoff until mid-century and then either slowly declining or constant runoff depending on the climate scenario. In the Juncal region in the Central Andes catchment runoff starts to decline sharply after 2031-2040, so that annual river runoff may decrease by up to 60% until the end of the century. While in the Juncal region the seasonality of runoff may change dramatically, due to less snow- and glacier melt during the summer, the seasonality of runoff in the Central Himalaya will be essentially unaffected by climate change. Differences in catchment response are explained by differences in climate change projections (as precipitation is projected to increase in the Central Himalaya but to decrease in the Central Andes), but also by the differences in glacier characteristics and glacier evolution. Meltwater production of glaciers in Juncal is already on a decline under the present climate. In Langtang, in contrast, the rate of glacier area decrease at lower elevations is exceeded by the rate of additional glacier area at high elevations contributing to melt in a warming climate. As a consequence of this, annual icemelt in the Central Himalaya will reach its peak not before mid-century.

  16. Occupational safety and health aspects of corporate social responsibility reporting in Japan from 2004 to 2012.

    Science.gov (United States)

    Nagata, Tomohisa; Nakata, Akinori; Mori, Koji; Maruyama, Takashi; Kawashita, Futoshi; Nagata, Masako

    2017-05-02

    A number of companies publish corporate social responsibility (CSR) reporting in booklets and other publicly available formats. The purpose of this paper is to clarify the nine-year (2004-2012) trend of occupational safety and health (OSH) activities as described in CSR reporting (by industry sector and company size). We investigated CSR reporting on the website in all Japanese companies listed on the first section of the Tokyo Stock Exchange. The data were extracted from CSR reporting of each company every year from 2004 to 2012. We counted the pages dedicated to information on OSH activities by industry sector and company size and calculated the rate of OSH divided by total CSR-related activities. The number of companies publishing CSR reports increased in all industry sectors, although the rate of inclusion of OSH activity within CSR reports increased only among sectors such as construction, manufacturing, transportation, and commerce. Among all company size, CSR reporting increased constantly throughout all observed years. The proportion of companies that had described OSH in CSR reporting increased from 2004 to 2012, and 76.5% companies had described OSH activities in 2012. The average number of pages of CSR-related report was 34.2 in 2004, increasing to 43.1 in 2012. The proportion of described pages of OSH activities in total CSR reporting increased gradually, and 2.7% in 2012. The focus of CSR reporting gradually shifted from 'environment' to 'social activity including OSH'. Majority of companies are putting more emphasis on OSH in CSR reporting in Japan.

  17. Radiocarbon dating and wiggle matching of wooden poles forming circular structures in the 1st Millennium BC at the Mawaki archaeological site, central Japan

    Energy Technology Data Exchange (ETDEWEB)

    Nishimoto, Hiroshi, E-mail: momo@nendai.nagoya-u.ac.j [Graduate School of Environmental Studies, Nagoya University, Nagoya Aichi 464-8602 (Japan); Nakamura, Toshio [Noto-Town Board of Education, Mawaki Noto-cho, Ishikawa 927-0562 (Japan); Takada, Hideki [Center for Chronological Research, Nagoya University, Nagoya Aichi 464-8602 (Japan)

    2010-04-15

    Wooden circular structures, presumed archaeologically as a structure related with ritual of ancient people in the Final Jomon period, are specific to archaeological sites excavated mainly in the coastal region around Noto peninsula, central Japan. So far, only few attempts have been made at chronological studies on these wooden structures. {sup 14}C dating has been attempted to wooden poles forming the structures, which had been excavated at the Mawaki archaeological site, Ishikawa prefecture, central Japan, to examine construction period of the structures. It was revealed that these structures were constructed in the Final Jomon period, most probably within 900-400 cal BC. In addition, we have tried wiggle matching of {sup 14}C ages for several annual rings separated from three and two poles that were constituting two circular structures, the oldest and the newest ones. {sup 14}C dates of annual rings measured with AMS were wiggle-matched to IntCal04 data sets by Bayesian statistics. The results indicated that the construction period of these wooden structures can be placed within ca. 820-680 cal BC, being narrowed by about 350 calendar years successfully.

  18. Occurrence factors of large vacant lots in central districts and their utilization by local governments in Japan

    Directory of Open Access Journals (Sweden)

    Takeshi Kobayashi

    2016-12-01

    Full Text Available In Japan, local cities experience a number of problems related to deterioration of residential environment, quality of public service, and vitalization of commercial land. Specifically, the presence of large vacant lots behind sizable stores, office buildings, hospitals, and factories devitalize urban activity and its landscape. Many local cities are seeking to actualize a sustainable compact city with an integrated population, commerce, traffic and other public services in ways that promote a low carbon and energy-conserving society. Against the backdrop of these issues, this study examines the occurrence of large vacant lots and their utilization by local governments in Japan based on a questionnaire and field survey. It highlights several cases in which a large vacant lot is used to forward the development of a compact city by a local government.

  19. Response to Masafumi Ogawa, "Music Teacher Education in Japan: Structure, Problems, and Perspectives"

    Science.gov (United States)

    Wheeler, Peggy

    2004-01-01

    Masafumi Ogawa's paper presents challenge after challenge facing the teacher and the teacher educator in Japan. One has the sense that a lifetime of frustrations with the national curriculum, the set-up of student teaching, and the definition of music as a school subject each made its way into the paper. Even choosing to focus on teacher training…

  20. Food after Fukushima--Japan's regulatory response to the radioactive contamination of its food chain.

    Science.gov (United States)

    Berends, Gijs; Kobayashi, Megumi

    2012-01-01

    The nuclear accident in Fukushima triggered a process of regulatory action, inspections, and market restrictions that has deeply affected the Japanese food market. When higher than permissible levels of radioactivity entered the food chain, the Japanese Government had to take strong measures to protect consumers. At the same time, it had to explore ways to avoid disproportionate penalties on the producers from the affected region. This article examines Japan's regulatory response to the nuclear accident and the legal instruments the government accordingly employed. Our analysis follows four regulatory steps that were taken by the government to safeguard the food chain: the establishment of maximum permissible levels for radioactive levels in food; the adoption of guidelines on how to monitor these levels; the restriction of the distribution and consumption of excessively contaminated food and, finally, where and when possible, the lifting of these restrictions. This article discusses how the Food and Drug Administration has come to adopt informal guidance (agency advice that influences regulated entities but does not carry the force and effect of law) as its primary method of policymaking, as opposed to more formalized procedures like notice-and-comment rulemaking or case-specific adjudication. Using major developments in administrative law and modifications to FDA's regulatory regime as milestones, the article traces how and why FDA's use of informal guidance to fulfill its statutory mandate has changed over the past century. Along the way, the article identifies important doctrinal questions that persist today, namely (1) whether informal advisory opinions bind FDA and (2) the degree of judicial deference guidance documents should receive under the Supreme Court's decisions in Chevron and Mead. The article attempts to resolve these doctrinal ambiguities. It then undertakes a normative analysis of FDA's increasing reliance on informal guidance, and conclude that

  1. Comparison between the European Central Bank as a New Monetary Experiment and other Major - Central Banks - US Federal Reserve and Bank of Japan

    Directory of Open Access Journals (Sweden)

    Tache I.

    2014-12-01

    Full Text Available Our goal is to make a survey of three major central banks practices and to emphasize both the different national characteristics and the similarities derived from the global changes of financial environment. Using a descriptive methodology, the comparison will concern the central banks’ goals, the institutional and organizational structures, strategies and tools of monetary policy

  2. Behavioral Response in the Immediate Aftermath of Shaking: Earthquakes in Christchurch and Wellington, New Zealand, and Hitachi, Japan.

    Science.gov (United States)

    Jon, Ihnji; Lindell, Michael K; Prater, Carla S; Huang, Shih-Kai; Wu, Hao-Che; Johnston, David M; Becker, Julia S; Shiroshita, Hideyuki; Doyle, Emma E H; Potter, Sally H; McClure, John; Lambie, Emily

    2016-11-15

    This study examines people's response actions in the first 30 min after shaking stopped following earthquakes in Christchurch and Wellington, New Zealand, and Hitachi, Japan. Data collected from 257 respondents in Christchurch, 332 respondents in Hitachi, and 204 respondents in Wellington revealed notable similarities in some response actions immediately after the shaking stopped. In all four events, people were most likely to contact family members and seek additional information about the situation. However, there were notable differences among events in the frequency of resuming previous activities. Actions taken in the first 30 min were weakly related to: demographic variables, earthquake experience, contextual variables, and actions taken during the shaking, but were significantly related to perceived shaking intensity, risk perception and affective responses to the shaking, and damage/infrastructure disruption. These results have important implications for future research and practice because they identify promising avenues for emergency managers to communicate seismic risks and appropriate responses to risk area populations.

  3. High-resolution detrital flux and provenance records from the Lake Suigetsu (SG06/12 cores) and climate changes in Central Japan during the last deglaciation

    Science.gov (United States)

    Nagashima, K.; Nakagawa, T.; Suzuki, Y.; Tada, R.; Sugisaki, S.; Bronk Ramsey, C.; Bryant, C. L.; Staff, R.; Brauer, A.; Lamb, H.; Schlolaut, G.; Tarasov, P. E.; Gotanda, K.; Haraguchi, T.; Yonenobu, H.; Yokoyama, Y.

    2013-12-01

    Stalagmites in Chinese caves (e.g., Wang et al., 2001, 2005), loess/paleosol sequence of the Chinese Loess Plateau, and lacustrine sediments in Asian countries are favorable to monitor the past changes in East Asian monsoon and the path and intensity of the Westerly Jet. However, not much is known about these changes during the last deglaciation mostly due to the large uncertainty in the chronologies of the lacustrine and loess/paleosol sediments. Lake Suigetsu in Central Japan is known for the varved sediments which cover at least last 70 kyr. Recently, precise Age-Model is established for SG06 core based on varve counting and more than 800 radiocarbon dates (e.g., Ramsey et al., 2012; Staff et al., 2013). Here we examine the precipitation and wind-system changes in Central Japan during the last deglaciation from the flux and provenance changes of the detrital materials in the sediments of SG06 core. We reconstructed flux of detrital materials for the last glacial part of the SG06 core (1402-1810 cm interval of the SG06 composite depth) with 1 cm resolution (corresponded to 7-13 yrs) and estimated provenance of the detrital materials using color, chemical compositions (please see a poster presented by Suzuki et al), grain sizes, and electron spin resonance intensity and crystallinity of the quartz (these methods were detailed in Nagashima et al., 2007, 2011). The reconstructed flux of detrital materials are characterized by the millennial-scale increases exceeding 12 mg/cm2/yr at 16,600-14,800 and 13,700-12,800 SG062012 yr BP and short-lived (centennial to decadal) episodes of higher flux repeated more than thirty times throughout the deglaciation. The grain sizes, color, and crystallinity of quartz suggest that the content of the detrital materials increased during 16,600-14,800 SG062012 yr BP, which was mostly due to suspended particles supplied from Hasu river through Lake Mikata, that is located immediately upstream of Lake Suigetsu and trapping most of coarse

  4. Japan 2003

    DEFF Research Database (Denmark)

    Ørstrup, Finn Rude; Hvass, Sven

    2003-01-01

    Kompendium udarbejdet til en studierejse til Japan  2003 Kunstakademiets Arkitektskole, Studieafdeling 10......Kompendium udarbejdet til en studierejse til Japan  2003 Kunstakademiets Arkitektskole, Studieafdeling 10...

  5. COMPARISON BETWEEN THE EUROPEAN CENTRAL BANK AS A NEW MONETARY EXPERIMENT AND OTHER MAJOR CENTRAL BANKS - US FEDERAL RESERVE AND BANK OF JAPAN

    National Research Council Canada - National Science Library

    I Tache; A L Danu

    2014-01-01

      Our goal is to make a survey of three major central banks practices and to emphasize both the different national characteristics and the similarities derived from the global changes of financial environment...

  6. Driving with central visual field loss I: Impact of central scotoma on response to hazards

    Science.gov (United States)

    Bronstad, P. Matthew; Bowers, Alex R.; Albu, Amanda; Goldstein, Robert; Peli, Eli

    2012-01-01

    Objective To determine how central field loss (CFL) affects reaction time to pedestrians and test the hypothesis that scotomas lateral to the preferred retinal locus will delay detection of hazards approaching from that side. Methods Eleven participants with binocular CFL (scotoma diameter 7°-25°; VA 0.3-1.0 logMAR) using lateral preferred retinal fixation loci and eleven matched controls with normal vision drove in a simulator for about an hour and a half per session, for two sessions a week apart. Participants responded to frequent virtual pedestrians that appeared on either the left or right sides, and approached the participants’ lane on a collision trajectory that, therefore, caused them to remain in approximately the same area of the visual field. Results CFL participants reacted more slowly to pedestrians that appeared in the area of visual field loss than in non-scotomatous areas (4.3 vs. 2.4 seconds, phazard detection even though small eye movements could potentially compensate for the loss. Responses in non-scotomatous areas were also delayed, though to a lesser extent, possibly due to the eccentricity of fixation. Our findings will help practitioners in advising patients with CFL about specific difficulties they may face when driving. PMID:23329309

  7. JPRS Report, Environmental Issues, Japan: Response Strategies for Global Warming Studied

    Science.gov (United States)

    2007-11-02

    dioxide absorbed in to the ocean changes and in some areas absorbtion turns to emission. The result of observation for the last 20 to 30 years shows...circulation pattern of air. 4) Increase of humidity and emission rates of trace gases, such as ammonia, DMS, hydrogen sulfide, nitric oxide, terpenes ...forestry are relatively small, it is respon- sible for about 1% of the total demand in Japan. However, the amount of wood and vegetation which absorb

  8. Seismic velocity structure and spatial distribution of reflection intensity off the Boso Peninsula, Central Japan, revealed by an ocean bottom seismographic experiment

    Science.gov (United States)

    Kono, Akihiro; Sato, Toshinori; Shinohara, Masanao; Mochizuki, Kimihiro; Yamada, Tomoaki; Uehira, Kenji; Shinbo, Takashi; Machida, Yuuya; Hino, Ryota; Azuma, Ryosuke

    2016-04-01

    Off the Boso Peninsula, central Japan, where the Sagami Trough is in the south and the Japan Trench is in the east, there is a triple junction where the Pacific plate (PAC), the Philippine Sea plate (PHS) and the Honshu island arc (HIA) meet each other. In this region, the PAC subducts beneath the PHS and the HIA, and the PHS subducts beneath the HIA. Due to the subduction of 2 oceanic plates, numerous seismic events took place in the past. In order to understand these events, it is important to image structure of these plates. Hence, many researchers attempted to reveal the substructure from natural earthquakes and seismic experiments. Because most of the seismometers are placed inland area and the regular seismicity off Boso is inactive, it is difficult to reveal the precise substructure off Boso area using only natural earthquakes. Although several marine seismic experiments using active sources were conducted, vast area remains unclear off Boso Peninsula. In order to improve the situation, a marine seismic experiment, using airgun as an active source, was conducted from 30th July to 4th of August, 2009. The survey line has 216 km length and 20 Ocean Bottom Seismometers (OBSs) were placed on it. We estimated 2-D P-wave velocity structure from the airgun data using the PMDM (Progressive Model Development Method; Sato and Kenett, 2000) and the FAST (First Arrival Seismic Tomography ; Zelt and Barton, 1998). Furthermore, we identified the probable reflection phases from the data and estimated the location of reflectors using Travel time mapping method (Fujie et al. 2006). We found some reflection phases from the data, and the reflectors are located near the region where P-wave velocity is 5.0 km/s. We interpret that the reflectors indicate the plate boundary between the PHS and the HIA. The variation of the intensity of reflection along the upper surface of PHS seems to be consistent with the result from previous reflection seismic experiment conducted by Kimura et

  9. [Expression of negative emotional responses to the 2011 Great East Japan Earthquake: Analysis of big data from social media].

    Science.gov (United States)

    Miura, Asako; Komori, Masashi; Matsumura, Naohiro; Maeda, Kazutoshi

    2015-06-01

    In this article, we investigated the expression of emotional responses to the 2011 Great East Japan Earthquake by analyzing the frequency of negative emotional terms in tweets posted on Twitter, one of the most popular social media platforms. We focused on differences in time-series variations and diurnal changes between two kinds of disasters: natural disasters (earthquakes and tsunamis) and nuclear accidents. The number of tweets containing negative emotional responses increased sharply shortly after the first huge earthquake and decreased over time, whereas tweets about nuclear accidents showed no correlation with elapsed time. Expressions of anxiety about natural disasters had a circadian rhythm, with a peak at midnight, whereas expressions of anger about the nuclear accident were highly sensitive to critical events related to the accident. These findings were discussed in terms of similarities and differences compared to earlier studies on emotional responses in social media.

  10. Frost damage of bricks composing a railway tunnel monument in Central Japan: field monitoring and laboratory simulation

    Directory of Open Access Journals (Sweden)

    C. Thomachot

    2005-01-01

    Full Text Available Bricks of tunnels and bridges of Usui Pass railway (Japan exposed to north are subject to frost damage. Average depth of erosion due to detachment of angular blocks is around 1-1.5 cm. In order to assess this weathering and to understand its mechanism, an experimental study was carried out in the field and laboratory. Field monitoring showed the combination of seasonal and diurnal freezing with a maximum of heave when the freezing front reached 5 cm depth. Bricks taken from the site were submitted to unidirectional freezing at capillary and vacuum saturation in the laboratory. Results showed that frost damage of bricks was favoured by high saturation level and repetition of freeze-thaw cycles.

  11. Annual layers in river-bed sediment of a stagnant river-mouth area of the Kitagawa Brook, Central Japan

    Science.gov (United States)

    Kurashige, Y.; Nakano, T.; Kasubuchi, E.; Maruo, M.; Domitsu, H.

    2015-03-01

    The river mouth of Kitagawa Brook is normally stagnant because it is easily closed by sand and gravel transported by littoral currents of Biwa Lake, Japan. A new urban area exists in the basin and sewerage works were constructed in the early 1990s, so contaminated water with a bad odour had flowed into the brook before the sewerage works. To reduce the smell, the river mouth was excavated to narrow the channel in the early 1980s. Thus, river-bed sediment after this excavation only occurs at the river mouth. From the upper 24 cm of a sediment core, we found 19 strata of leaves which were supplied from deciduous trees in autumn. We also found several gravel layers which were supplied from the lake during severe storms. The combination of veins and gravel layers were reconstructed for about 20 years of sediment records with an error of two to three years.

  12. Educational needs concerning disaster preparedness and response: a comparison of undergraduate nursing students from Istanbul, Turkey, and Miyazaki, Japan.

    Science.gov (United States)

    Oztekın, Seher Deniz; Larson, Eric Edwin; Altun Uğraş, Gülay; Yüksel, Serpil

    2014-04-01

    To compare 4 year undergraduate nursing students' educational needs concerning disaster preparedness and response in Istanbul and Miyazaki. This was a 13 question descriptive/comparative survey. Females, aged 18-22 years, and in their second year of their nursing programs, rarely participate in disaster preparedness and response courses at their universities (75.2%) or outside (89.8%). Educational needs of Miyazaki's students who had already participated in these courses (85%) were higher than in Istanbul's (67.2%). Of those whose educational needs had not been met, 55.9% were considering taking another lecture/course in one of the following years (Istanbul, 47.4%; Miyazaki, 71.4%). The majority of students from Istanbul reported some knowledge about disaster preparedness and response from courses at their universities while Miyazaki's students showed less. Effective teaching methods/resources were mock drills. Nursing interventions in disaster situations in "response competencies" were preferred issues to be included in course content (Istanbul, 90.4%; Miyazaki, 93.1%). Most student nurses had no expectations on skills that could be gained from a disaster preparedness and response course/culture of disaster lecture (Istanbul, 48.7%; Miyazaki, 34.5%). Nursing students in both cities seem more likely to participate in disaster preparedness and response courses/lectures. The present study also addresses the need to incorporate mass casualty care and disaster management skills into undergraduate curricula. Core contents for nursing curricula in both cities need to be continued. Outcome competencies must be identified and validated through further research. © 2013 The Authors. Japan Journal of Nursing Science © 2013 Japan Academy of Nursing Science.

  13. Molecular identification of Anisakis and Hysterothylacium larvae in marine fishes from the East China Sea and the Pacific coast of central Japan.

    Science.gov (United States)

    Kong, Qingming; Fan, Lanfen; Zhang, Junhe; Akao, Nobuaki; Dong, Kewei; Lou, Di; Ding, Jianzu; Tong, Qunbo; Zheng, Bin; Chen, Rui; Ohta, Nobuo; Lu, Shaohong

    2015-04-16

    Anisakiasis is a human disease caused by the accidental ingestion of larvae belonging to the family Anisakidae. Three fish species, the small yellow croaker Pseudosciaena polyactis, the mackerel Pneumatophorus japonicus and the hairtail Trichiurus haumela are important source for food products in the East China Sea. The prevalence and the identification of Anisakidae larvae in these fishes will benefit the prevention and control of anisakiasis. In this study, fish samples were obtained from fish markers in the East China Sea and the Pacific coast of central Japan during April 2011 and July 2013. For species identification, the PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis of the entire ITS region (ITS1, 5.8 S and ITS2) of nuclear ribosomal DNA (rDNA) was performed. In total, 2004 larvae were collected from 80 hairtail fish, 20 small yellow croaker, and 27 mackerel from the East China Sea and the Pacific coast of central Japan. High prevalence of Anisakidae larvae infection (116/122, 95.1%) was detected in the East China Sea. Seven species were identified belonging to the genera Anisakis (Nematoda: Anisakidae) and Hysterothylacium (Nematoda: Anisakidae). Anisakis pegreffii was the predominant species accounting for 84.8% of all larvae examined in East China Sea, while all Anisakidae larvae isolated from Japan were identified as Anisakis simplex sensu stricto (s.s.). In the East China Sea, A. simplex s.s. and Anisakis typica were 0.6% (4/619) and 1.5% (9/619) of the identified nematodes, respectively. Interestingly, one larva was identified as a recombinant genotype of A. simplex s.s. and A. pegreffii. In addition, four species of the genus Hysterothylacium, namely, Hysterothylacium amoyense (31/619, 5.0%), Hysterothylacium aduncum (10/619, 1.6%), Hysterothylacium fabri (21/619, 3.4%) and Hysterothylacium spp. (18/619, 2.9%) were also identified in the present study. This is a comprehensive epidemiological dataset for the family Anisakidae in

  14. EARLY STAGE RESPONSES OF INTENSIVE CARE UNITS DURING MAJOR DISASTERS: FROM THE EXPERIENCES OF THE GREAT EAST JAPAN EARTHQUAKE.

    Science.gov (United States)

    Shimada, Jiro; Tase, Choichiro; Tsukada, Yasuhiko; Hasegawa, Arifumi; Iida, Hiroshi

    2015-01-01

    The present study investigated the role of intensive care units (ICU) during disasters, including the responses of our ICU following the Great East Japan Earthquake on March 11, 2011. Our ICU comprises 8 beds for postoperative inpatients and those with rapidly deteriorating conditions; 20 beds in an emergency unit for critically ill patients; and 17 beds for neonates. It is important to secure empty beds when a major disaster occurs, as was the case after the Great Hanshin Earthquake, due to the resulting large numbers of trauma patients. Therefore, each ICU section cooperated to ensure sufficient space for admissions following the Great East Japan Earthquake. However, unlike the Great Hanshin Earthquake, securing beds was ultimately unnecessary due to the nature of the recent disaster, which also consisted of a subsequent tsunami and nuclear accident. Therefore, air quality monitoring was required on this occasion due to the risk of environmental radioactive pollution from the nuclear disaster causing problems with artificial respiration management involving atmospheric air. The variability in damage arising during different disasters thus requires a flexible response from ICUs that handle seriously ill patients.

  15. Risk factors and treatment responses in patients with vitiligo in Japan--A retrospective large-scale study.

    Science.gov (United States)

    Ohguchi, Ryoko; Kato, Hiroshi; Furuhashi, Takuya; Nakamura, Motoki; Nishida, Emi; Watanabe, Shoichi; Shintani, Yoichi; Morita, Akimichi

    2015-05-01

    Vitiligo is a refractory skin disease. To investigate the risk factors and treatment responses of patients with vitiligo in Japan, we recorded and analyzed the details of 713 vitiligo patients (comorbidity, treatment responses, family history, age, and sex) who visited the dermatology clinic of the Nagoya City University Hospital, Nagoya, Japan between January 2004 and August 2010 (mean age, 35.2 years; 302 men, 411 women) using logistic regression analysis. The results are expressed as odds ratios (OR) with 95% confidence interval (CI). Patients were diagnosed with vitiligo [n = 644; 338 generalized type (47.4%), 170 segmental type (23.8%), and 136 localized type (19.1%)], nevus depigmentosus (n = 53, 7.4%), halo nevus (n = 14, 2.0%), and hypomelanosis of Ito (n = 2, 0.3%). For generalized and localized types, none of the analyzed factors were statistically significant. For the segmental type, antinuclear antibody (OR = 1.005; 95% CI, 1.00-1.01; p 55 years (OR = 0.0171; 95% CI, 0.00333-0.0879; p vitiligo.

  16. Public health challenges and legacies of Japan's response to the Ebola virus disease outbreak in West Africa 2014 to 2015.

    Science.gov (United States)

    Saito, Tomoya

    2015-01-01

    The largest outbreak of Ebola virus disease occurred in West Africa in 2014 and resulted in unprecedented transmission even in distant countries. In Japan, only nine individuals were screened for Ebola and there was no confirmed case. However, the government promoted the reinforcement of response measures and interagency collaboration, with training and simulation exercises conducted country-wide. The legacies included: publication of a communication policy on case disclosure, a protocol for collaboration between public health and other agencies, and establishing an expert committee to assemble the limited available expertise. There were challenges in taking proportionate and flexible measures in the management of people identified to be at high risk at entry points to Japan, in the decentralised medical response strategy, and in the medical countermeasures preparedness. The Ebola outbreak in West Africa provided a crucial opportunity to reveal the challenges and improve the preparedness for rare but high impact emerging diseases that are prone to be neglected. Efforts to uphold the lessons learnt and maintain public health preparedness should help prepare for future emerging diseases, including bioterrorist acts and pandemics.

  17. Kozu-Matsuda fault system in northern Izu collision zone, western part of Kanagawa Prefecture, central Japan

    Science.gov (United States)

    Odawara, K.; Aketagawa, T.; Yoshida, A.

    2010-12-01

    Western area of Kanagawa Prefecture is techtonically highlighted by its geological setting that the Izu-Bonin volcanic arc collides with the Japan Island arc there. The Kozu-Matsuda fault system which consists of the Kozu-Matsuda fault, the Matsuda-kita fault, the Hinata fault and the Hirayama fault is a surface manifestation of the plate boundary. Research of the Kozu-Matsuda fault has advanced dramatically after the 1995 Kobe Earthquake. Having conducted a trench survey, Kanagawa Prefectural Government (2004) reported that the Kozu-Matsuda fault was activated at least four times in the past 4000 years and the latest activity occurred 650-950 years ago (AD. 1350-1050). However, details of the activity of the Hinata and Hirayama faults, the northern extension of the Kozu-Matsuda fault, are not well understood. The Special Project for Earthquake Disaster Mitigation in Urban areas (DaiDaiToku) made a 2040 m deep drilling in 2004 in Yamakita Town (Hayashi et al., 2006). DaiDaiToku also carried out the seismic reflection profiling along a route from Odawara to Yamanashi in 2005 (Sato et al., 2005). The study done by DaiDaiToku elucidated presence of two north-dipping thrusts. The northern thrust corresponds to the Hinata fault, and the southern one which is also considered to be a continuation of the Kozu-Matsuda fault probably represents a frontal thrust (Miyauchi et al., 2006). We have conducted paleoseismic investigations using data from boreholes across these thrusts.

  18. Channel geometry change of a first-order stream after a small debris flow in Ashio Mountains of central Japan

    Science.gov (United States)

    Hattanji, T.; Wasklewicz, T.

    2006-12-01

    We examined geometry change of a steep first-order channel with a laserscanner before and after a small debris flow. The study site is located in chert area, Ashio Mountains, Japan. On August 12, 2005, a 20-year storm event with maximum 1-hour rainfall of 75.4 mm/h triggered a small landslide at a steep channel head. The sliding material moved as a debris flow along the first-order channel (C3) to the mouth. We successfully measured high-resolution channel topography with the Leica Geosystems High-Definition Surveying Laser Scanner before (April 30) and after the debris-flow event (October 9-11). Width, depth and other related parameters were measured for 30 selected cross sections. Bankfull stage of this first-order channel after the debris-flow event is much higher than two-year flood stage. The magnitude of channel geometry change varies non-linearly in downstream direction. The non-linear variability is attributed to differences in stream bed and bank characteristics. Bedrock-channel reach is less impacted by the debris flow. The largest magnitude changes in the channel geometry parameters occur along colluvially confined channel reaches.

  19. Re-evaluation of the regional tectonic stress fields and faulting regimes in central Kyushu, Japan, behind the 2016 Mw 7.0 Kumamoto Earthquake

    Science.gov (United States)

    Yoshida, Masaki

    2017-08-01

    To re-evaluate the regional tectonic stress fields in central Kyushu, Japan, the region in which the 2016 Kumamoto Earthquakes occurred on 14 April 2016 (Mw 6.2) and 16 April (Mw 7.0), the faulting regimes in central Kyushu were analyzed using the focal mechanisms of this earthquake sequence. Results show that almost all of the focal mechanisms of the earthquakes occurring along the active Futagawa-Hinagu fault zone fall into two spatial faulting regimes: a strike-slip (SS) regime along this fault zone and a pure normal faulting (NF) regime without or with minor strike-slip component in the northern part of this fault zone. In terms of the relationship between the two horizontal principal stresses acting on Kyushu Island, these two regimes are regarded as a set of tectonics stress fields. The highly accumulated strain energy along this fault zone and asymmetrically unbalanced stress condition for the maximum horizontal principal stress acting on the east-west sides of the crustal blocks in this area expected from a pair of these two regimes might explain the relatively large number of aftershocks following the Kumamoto Earthquake as compared to other recent inland earthquakes in the Japanese Islands. From the results of the present analyses, it is considered that the regional stress field of Honshu Island could be extended to Kyushu Island and that the kinematics of the Philippine Sea Plate may have been affecting the stress field in Kyushu since the late Miocene.

  20. Central adaptation of pain perception in response to rehabilitation of musculoskeletal pain

    DEFF Research Database (Denmark)

    Andersen, Lars L; Andersen, Christoffer H; Sundstrup, Emil

    2012-01-01

    Understanding the mechanisms of long-standing musculoskeletal pain and adaptations in response to physical rehabilitation is important for developing optimal treatment strategies. The influence of central adaptations of pain perception in response to rehabilitation of musculoskeletal pain remains...

  1. Central adaptation of pain perception in response to rehabilitation of musculoskeletal pain

    DEFF Research Database (Denmark)

    Andersen, Lars L; Andersen, Christoffer H; Sundstrup, Emil

    2012-01-01

    Understanding the mechanisms of long-standing musculoskeletal pain and adaptations in response to physical rehabilitation is important for developing optimal treatment strategies. The influence of central adaptations of pain perception in response to rehabilitation of musculoskeletal pain remains...

  2. A record of the upper Olduvai geomagnetic polarity transition from a sediment core in southern Yokohama City, Pacific side of central Japan

    Science.gov (United States)

    Kusu, Chie; Okada, Makoto; Nozaki, Atsushi; Majima, Ryuichi; Wada, Hideki

    2016-12-01

    A detailed paleomagnetic record of the upper Olduvai polarity transition was obtained from a 106.72 m-long sediment core drilled in southern Yokohama City, located on the northern Miura Peninsula, on the Pacific side of central Japan. The core spans the upper part of the Nojima Formation and the lowermost part of the Ofuna Formation, both of which correspond to the middle Kazusa Group (Lower Pleistocene forearc basin fill). The record was reconstructed using discrete specimens taken throughout mudstone and/or sandy mudstone sequences in the Nojima Formation. In this record, the virtual geomagnetic pole (VGP) fluctuation accompanying the polarity transition was determined to occur between depths of 66.99 and 63.60 m. These depths have been dated at 1784.4 and 1779.9 ka, respectively, and the duration of the polarity transition is estimated to be 4.5 kyr using an age model based on a δ18O record from that core. The VGP paths during the transition do not appear to show any preferred longitudinal bands. However, the VGP positions cluster in five areas: (A) eastern Asia near Japan, (B) the Middle East, (C) eastern North America (North Atlantic), (D) off southern Australasia, and (E) the southern South Atlantic off South Africa. The primary locations of the observed VGP clusters coincide with the areas on the Earth's surface that possess a strong downward flux of the vertical component of the present geomagnetic non-axial dipole field. The relative paleointensity rapidly decreased approximately 1 kyr before the beginning of the polarity transition and gradually recovered to its initial level in 12 kyr.

  3. Two modes of occurrence of garnets from the Tonaru metagabbro mass in the Sambagawa metamorphic belt, central Shikoku, Japan

    OpenAIRE

    蔵谷, 樹; 高須, 晃; カビール, エムデイ ファズレー

    2015-01-01

    Garnet epidote amphibolite from the central part of the Tonaru metagabbro mass consists mainly of garnet, epidote and amphibole (ferro-hornblende), with small amounts of quartz, plagioclase (albite and oligoclase) and paragonite. Rutile, apatite, hematite, calcite and chlorite occur occasionally. Garnets in the garnet epidote amphibolites exhibit two modes of occurrence. Garnet 1 (Grt 1) occurs as porphyroblast, and garnet 2 (Grt 2) is found as fine grain in the matrix. Porphyroblastic garnet...

  4. Variations in airborne bacterial communities at high altitudes over the Noto Peninsula (Japan in response to Asian dust events

    Directory of Open Access Journals (Sweden)

    T. Maki

    2017-10-01

    Full Text Available Aerosol particles, including airborne microorganisms, are transported through the free troposphere from the Asian continental area to the downwind area in East Asia and can influence climate changes, ecosystem dynamics, and human health. However, the variations present in airborne bacterial communities in the free troposphere over downwind areas are poorly understood, and there are few studies that provide an in-depth examination of the effects of long-range transport of aerosols (natural and anthropogenic particles on bacterial variations. In this study, the vertical distributions of airborne bacterial communities at high altitudes were investigated and the bacterial variations were compared between dust events and non-dust events.Aerosols were collected at three altitudes from ground level to the free troposphere (upper level: 3000 or 2500 m; middle level: 1200 or 500 m; and low level: 10 m during Asian dust events and non-dust events over the Noto Peninsula, Japan, where westerly winds carry aerosols from the Asian continental areas. During Asian dust events, air masses at high altitudes were transported from the Asian continental area by westerly winds, and laser imaging detection and ranging (lidar data indicated high concentrations of non-spherical particles, suggesting that dust-sand particles were transported from the central desert regions of Asia. The air samples collected during the dust events contained 10–100 times higher concentrations of microscopic fluorescent particles and optical particle counter (OPC measured particles than in non-dust events. The air masses of non-dust events contained lower amounts of dust-sand particles. Additionally, some air samples showed relatively high levels of black carbon, which were likely transported from the Asian continental coasts. Moreover, during the dust events, microbial particles at altitudes of  >  1200 m increased to the concentrations ranging from 1. 2 × 106 to 6

  5. Temporal and spatial variation of groundwater in quantity and quality in sand dune at coastal region, Kamisu city, central Japan.

    Science.gov (United States)

    Umei, Yohei; Tsujimura, Maki; Sakakibara, Koichi; Watanabe, Yasuto; Minema, Motomitsu

    2016-04-01

    The role of groundwater in integrated water management has become important in recent 10 years, though the surface water is the major source of drinking water in Japan. Especially, it is remarked that groundwater recharge changed due to land cover change under the anthropogenic and climatic condition factors. Therefore, we need to investigate temporal and spatial variation of groundwater in quantity and quality focusing on the change during recent 10-20 years in specific region. We performed research on groundwater level and quality in sand dune at coastal region facing Pacific Ocean, Kamisu city, Ibaraki Prefecture, which have been facing environmental issues, such as land cover change due to soil mining for construction and urbanization. We compared the present situation of groundwater with that in 2000 using existed data to clarify the change of groundwater from 2000 to 2015. The quality of water is dominantly characterized by Ca2+-HCO3- in both 2000 and 2015, and nitrate was not observed in 2015, though it was detected in some locations in 2000. This may be caused by improvement of the domestic wastewater treatment. The topography of groundwater table was in parallel with that of ground surface in 2015, same as that in 2000. However, a depletion of groundwater table was observed in higher elevation area in 2015 as compared with that in 2000, and this area corresponds to the locations where the land cover has changed due to soil mining and urbanization between 2015 and 2000. In the region of soil mining, the original soil is generally replaced by impermeable soil after mining, and this may cause a decrease of percolation and net groundwater recharge, thus the depletion of groundwater table occurred after the soil mining.

  6. Hemagglutinating virus of Japan envelope (HVJ-E) can enhance the immune responses of swine immunized with killed PRRSV vaccine

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Zhihong [State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing 100094 (China); China Institute of Veterinary Drug Control, Beijing 100081 (China); Zhang, Quan [College of Veterinary Medicine, Yangzhou University, Yangzhou 225009 (China); Wang, Zaishi [China Institute of Veterinary Drug Control, Beijing 100081 (China); Zhang, Zhongqiu [State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing 100094 (China); Veterinary Bureau, Ministry of Agriculture of the People' s Republic of China, Beijing 100125 (China); Guo, Pengju [Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences, Guangdong 510640 (China); Zhao, Deming, E-mail: zhaodm@cau.edu.cn [State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing 100094 (China)

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer We investigated the immunoadjuvant effects of HVJ-E on killed PRRSV vaccine. Black-Right-Pointing-Pointer HVJ-E enhanced the humoral and cellular responses of the piglets to PRRSV. Black-Right-Pointing-Pointer It is suggested that HVJ-E could be developed as a new-type adjuvant for mammals. -- Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically detrimental pig pathogen that causes significant losses for the pig industry. The immunostimulatory effects of hemagglutinating virus of Japan envelope (HVJ-E) in cancer therapy and the adjuvant efficacy of HVJ-E have been previously evaluated. The objective of this study was to investigate the adjuvant effects of HVJ-E on immunization with killed PRRSV vaccine, and to evaluate the protective effects of this immunization strategy against virulent PRRSV infection in piglets. Next, the PRRSV-specific antibody response, lymphocyte proliferation, PRRSV-specific IL-2, IL-10 and IFN-{gamma} production, and the overall protection efficacy were evaluated to assess the immune responses of the piglets. The results showed that the piglets inoculated simultaneously with killed PRRSV vaccine and HVJ-E had a significantly stronger immune response than those inoculated with killed PRRSV vaccine alone. Our results suggest that HVJ-E could be employed as an effective adjuvant to enhance the humoral and cellular responses of piglets to PRRSV.

  7. Seed bank response to prescribed fire in the central Appalachians.

    Science.gov (United States)

    Thomas M. Schuler; Melissa Thomas Van-Gundy; Mary B. Adams; W. Mark. Ford

    2010-01-01

    Pre- and post-treatment seed-bank characteristics of woody species were compared after two prescribed fires in a mesic mixed-oak forest in the central Appalachians. Nineteen woody species were identified from soil samples. Mean species richness declined but evenness did not after prescribed burning. The...

  8. The slow slip event in the Tokai region, central Japan, since 2013 as seen from GPS data

    Science.gov (United States)

    Sakaue, H.; Fukuda, J.; Kato, T.; Nishimura, T.

    2016-12-01

    In the Tokai region, cetral Japan, the previous long-term slow slip event (SSE) occurred on the subducting Philippine Sea plate from 2000 to 2005, the longest SSE ever found. In addition, many short-term SSEs have been observed in the Tokai region since 2004. Ozawa et al. (2016) reported that a slow slip event seems to have started in the similar area of the previous Tokai long term SSE in the beginning of 2013. We analyzed GPS data in the Tokai region to estimate the temporal evolution of the current event. GPS data from 1 Jan. 2008 to 30 Apr. 2015 were used in this study. The GIPSY-OASIS II software was used to estimate daily coordinates of 226 GPS stations from the GEONET in the Tokai district. The 2011 Tohoku-oki earthquake (Mw9.0) occurred on 11 Mar. 2011 and post-seismic deformation has also been observed in the Tokai region since then. Therefore, the effects of the post-seismic deformation due to the Tohoku-oki earthquake were removed by fitting the data from 11 Mar. 2011 to 31 Dec. 2012 with simple mathematical functions. We approximate the post-seismic deformations by the sum of exponential and logarithmic functions and subtract the estimated post-seismic deformation from the GPS time series. After removing this compornent, we applied a time-dependent inversion method to the data to obtain the spatio-temporal evolution of slip on the Philippine Sea plate beneath the Tokai region. For this purpose, we used a modified Network Inversion Filter (NIF) (Fukuda et al., 2008). The original NIF (Segall and Matthews, 1997) assumes a constant hyperparameter for the temporal smoothing of slip rate and thus results in oversmoothing of slip rate. The modified NIF assumes a time variable hyperparameter, so that changes in slip rate are effectively extracted from GPS time series. The results indicate that maximum slip for the long-term SSE from 1 Jan. 2013 to 30 Apr. 2015 was estimated to be about 6 cm and the large slip was located in nearly the same area as or slightly

  9. Public health response to the combined Great East Japan Earthquake, tsunami and nuclear power plant accident: perspective from the Ministry of Health, Labour and Welfare of Japan

    Directory of Open Access Journals (Sweden)

    Tomoya Saito

    2011-12-01

    Full Text Available At 14:46 on 11 March 2011, eastern Japan was struck by the largest earthquake in Japan's recorded history. With the epicentre off the Sanriku coast, the magnitude 9.0 quake triggered a tsunami, which together with the effects of the quake ignited a serious accident at a nuclear power plant. The damage was grave and widespread with the death toll as of 9 November 2011 at 15 835 and the number of missing and unaccounted for at 3664.1 Immediately after the earthquake, the Japanese Government, local governments in the stricken areas, hospitals, external organizations and volunteers launched coordinated relief and recovery activities. The role of the Ministry of Health, Labour and Welfare (MHLW in a disaster includes securing medical and nursing care, providing public health services and ensuring the safety of food and water supplies.

  10. Behavioral Response in the Immediate Aftermath of Shaking: Earthquakes in Christchurch and Wellington, New Zealand, and Hitachi, Japan

    Directory of Open Access Journals (Sweden)

    Ihnji Jon

    2016-11-01

    Full Text Available This study examines people’s response actions in the first 30 min after shaking stopped following earthquakes in Christchurch and Wellington, New Zealand, and Hitachi, Japan. Data collected from 257 respondents in Christchurch, 332 respondents in Hitachi, and 204 respondents in Wellington revealed notable similarities in some response actions immediately after the shaking stopped. In all four events, people were most likely to contact family members and seek additional information about the situation. However, there were notable differences among events in the frequency of resuming previous activities. Actions taken in the first 30 min were weakly related to: demographic variables, earthquake experience, contextual variables, and actions taken during the shaking, but were significantly related to perceived shaking intensity, risk perception and affective responses to the shaking, and damage/infrastructure disruption. These results have important implications for future research and practice because they identify promising avenues for emergency managers to communicate seismic risks and appropriate responses to risk area populations.

  11. Dike Intrusion Process of 2000 Miyakejima - Kozujima Event estimated from GPS measurements in Kozujima - Niijima Islands, central Japan

    Science.gov (United States)

    Murase, M.; Nakao, S.; Kato, T.; Tabei, T.; Kimata, F.; Fujii, N.

    2003-12-01

    Kozujima - Niijima Islands of Izu Volcano Islands are located about 180 km southeast of Tokyo, Japan. Although the last volcano eruptions in Kozujima and Niijima volcanoes are recorded more than 1000 year before, the ground deformation of 2-3 cm is detected at Kozujima - Niijima Islands by GPS measurements since 1996. On June 26, 2000, earthquake swarm and large ground deformation more than 20 cm are observed at Miyakejima volcano located 40 km east-southeastward of Kozu Island, and volcano eruption are continued since July 7. Remarkable earthquake swarm including five earthquakes more than M5 is stretching to Kozushima Island from Miyakejima Island. From the rapid ground deformation detected by continuous GPS measurements at Miyakejima Island on June 26, magma intrusion models of two or three dikes are discussed in the south and west part of Miyakejima volcano by Irwan et al.(2003) and Ueda et al.(2003). They also estimate dike intrusions are propagated from southern part of Miyakejima volcano to western part, and finally dike intrusion is stretching to 20 km distance toward Kozujima Island. From the ground deformation detected by GPS daily solution of Nation-wide dense GPS network (GEONET), some dike intrusion models are discussed. Ito et al.(2002) estimate the huge dike intrusion with length of about 20 km and volume of 1 km3 in the sea area between the Miyake Island and Kozu Island. (And) Nishimura et al.(2001) introduce not only dike but also aseismic creep source to explain the deformation in Shikinejima. Yamaoka et al.(2002) discuss the dike and spherical deflation source under the dike, because of no evidence supported large aseismic creep. They indicate a dike and spherical deflation source model is as good as dike and creep source model. In case of dike and creep, magma supply is only from the chamber under the Miyakejima volcano. In dike and spherical deflation source model, magma supply is from under Miyakejima volcano and under the dike. Furuya et al

  12. Re-examination of the damage distribution and the source of the 1828 Sanjo Earthquake in central Japan

    Science.gov (United States)

    Nishiyama, A.; Satake, K.; Yata, T.; Urabe, A.

    2010-12-01

    The Sanjo earthquake occurred in the mid-Niigata Prefecture, Japan, at around 6 or 7 a.m. on 18 December, 1828, and caused serious damage especially in the town of Sanjo. The epicenter and source fault were previously investigated by Usami (2003) and Uetake et al. (2005). Usami (2003) also estimated the magnitude as 6.9. According to historical records, the number of completely collapsed houses is 2418 in Sanjo town, in the flood plain of Shinano river, and 305 in Yoita town, on the western edge of Nagaoka plain. These two towns were the large population centers in those days. However, it is erroneous to conclude that the source of this earthquake is around Sanjo or Yoita town from the number of collapsed houses, because large population towns yield more collapsed houses. Therefore, we investigate damages in the other areas, and also estimate damage ratio in order to specify the focal region of the Sanjo Earthquake. We selected three reliable historical records which describe the original population and number of houses, as well as casualties or damages caused by this earthquake. The first document, compiled by Kuwana feudal clan, records the numbers of total houses and damaged houses at 54 villages. The second historical document seems to be based on a report which compiled damages and casualties to a public office of the Nagaoka feudal clan, and records the numbers of houses and of non-collapsed houses. The third document describes the number of houses and damages of each house (burned, collapsed or partially collapsed) in each region of Yoita town. The collapse ratio of houses at each village estimated from the above three historical documents is then converted into Japanese seismic intensity scale based on Usami (1986)'s table, i.e. Seismic intensity 7 (XII on MM scale) : 81 - 100 % collapse ratio of houses. Seismic intensity 6 (X - XI on MM scale): 71 - 80 % collapse ratio of houses. Seismic intensity 5+ (IX on MM scale) : 1 - 70 % collapse ratio of houses

  13. Atmospheric Response to Fukushima Daiichi NPP (Japan) Accident Reviled by Satellite and Ground observations

    CERN Document Server

    Ouzounov, D; Hattori, K; Kafatos, M; Taylor, P

    2011-01-01

    Immediately after the March 11, 2011 earthquake and tsunami in Japan we started to continuously survey the Outgoing Long-wavelength Radiation (OLR, 10-13 microns) from NOAA/AVHRR. Our preliminary results show the presence of hot spots on the top of the atmosphere over the Fukushima Daiichi Nuclear Power Plant (FDNPP) and due to their persistence over the same region they are most likely not of meteorological origin. On March 14 and 21 we detected a significant increase in radiation (14 W/m2) at the top of the atmosphere which also coincides with a reported radioactivity gas leaks from the FDNPP. After March 21 the intensity of OLR started to decline, which has been confirmed by ground radiometer network. We hypothesize that this increase in OLR was a result of the radioactive leaks released in atmosphere from the FDNPP. This energy triggers ionization of the air near the ground and lead to release of latent heat energy due to change of air humidity and temperature. Our early results demonstrate the potential ...

  14. Evaluation of energy responses for neutron dose-equivalent meters made in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Saegusa, J. E-mail: saegusa@popsvr.tokai.jaeri.go.jp; Yoshizawa, M.; Tanimura, Y.; Yoshida, M.; Yamano, T.; Nakaoka, H

    2004-01-01

    Energy responses of three types of Japanese neutron dose-equivalent (DE) meters were evaluated by Monte Carlo simulations and measurements. The energy responses were evaluated for thermal neutrons, monoenergetic neutrons with energies up to 15.2 MeV, and also for neutrons from such radionuclide sources as {sup 252}Cf and {sup 241}Am-Be. The calculated results were corroborated with the measured ones. The angular dependence of the response and the DE response were also evaluated. As a result, reliable energy responses were obtained by careful simulations of the proportional counter, moderator and absorber of the DE meters. Furthermore, the relationship between pressure of counting gas and response of the DE meter was discussed. By using the obtained responses, relations between predicted readings of the DE meters and true DE values were studied for various workplace spectra.

  15. Distribution of 36Cl in the Yoro River Basin, Central Japan, and Its Relation to the Residence Time of the Regional Groundwater Flow System

    Directory of Open Access Journals (Sweden)

    Akihiko Kondoh

    2011-01-01

    Full Text Available This study investigates the potential of 36Cl in tracing young groundwater with residence times of up to ~50 years. Groundwater samples were obtained from 16 irrigation wells in paddy fields located within an upland–lowland system in the Yoro River basin, Central Japan. The 36Cl/Cl ratios were in the range of 17 to 362 × 10−15. Among the samples with higher Cl− concentrations (>10 mg/L, two samples showed high nitrate concentrations as well (>30 mg/L. Except for these samples, the distribution of 36Cl in groundwater was essentially consistent with previous tritium concentration data measured in 1982 and 1994, considering the time that has elapsed since these earlier measurements were performed. 36Cl/Cl values were less than 30 × 10−15 in lowland areas, with higher values in and around upland areas. The results indicate longer residence times in the regional groundwater flow system (>50 years than those estimated in previous studies, especially in the area west of the Yoro River. The results demonstrate the ability of 36Cl to trace young groundwater flow, particularly because high values of bomb-derived 36Cl/Cl are easily discriminated from pre-bomb water with low 36Cl/Cl values. Because of its very long half-life (3.01 × 105 years, 36Cl remains even after tritium is no longer available.

  16. Effects of climatic conditions on annual shoot length and tree-ring width of alpine dwarf pine Pinus pumila in central Japan.

    Science.gov (United States)

    Takahashi, Koichi; Aoki, Keigo

    2015-07-01

    This study compared the effects of climatic conditions on annual shoot length (ASL) and tree-ring width (TRW) of alpine dwarf pine Pinus pumila in central Japan, by using dendrochronological techniques. Chronologies of ASL (1951-2009) and TRW (1972-2009) were standardized to remove non-climatic signals, and correlation tests were done for non-standardized observed values and standardized indices with monthly temperatures and precipitation. Monthly mean temperatures from March to October, except for July, increased during 1951‒2009; observed values and a standardized index of ASL increased during this period. For the rate of increase in ASL, the standardized index was lower than the observed values. However, these values of TRW showed no trends. The observed values and standardized index of TRW positively correlated with temperatures of the beginning of the growing season of the current year. The observed values of ASL positively correlated with temperatures during the growing season of the previous and current years. However, the standardized index of ASL positively correlated with only June temperatures of the previous and current years. The different results of ASL between observed values and standardized indices indicate that many significant correlations of observed values were attributable to increasing trends of temperature and ASL. This study suggests that standardized ASL of P. pumila tended to increase greater than TRW, that high temperatures at the beginning of the growing season increases ASL and TRW, and that analyzing observed values of ASL may overestimate the effects of temperature on ASL of P. pumila.

  17. Quaternary strike-slip crustal deformation around an active fault based on paleomagnetic analysis: a case study of the Enako fault in central Japan

    Science.gov (United States)

    Kimura, Haruo; Itoh, Yasuto; Tsutsumi, Hiroyuki

    2004-10-01

    To evaluate cumulative strike-slip deformation around an active fault, we carried out tectonic geomorphic investigations of the active right-lateral strike-slip Enako fault in central Japan and paleomagnetic investigations of the Kamitakara pyroclastic flow deposit (KPFD; 0.6 Ma welded tuff) distributed around the fault. Tectonic geomorphic study revealed that the strike-slip displacement on the fault is ca. 150 m during the past 600 ka. We carried out measurements of paleomagnetic directions and anisotropy of magnetic susceptibility (AMS) within the pyroclastic flow deposit. Stable primary magnetic directions at each sampling site are well clustered and the AMS fabric is very oblate. We then applied tilt correction of paleomagnetic directions at 15 sites using tilting data obtained by the AMS property and orientations of eutaxitic structures. Within a distance of about 500 m from the fault trace, differential clockwise rotations were detected; the rotation angle is larger for zones closer to the fault. Because of this relation and absence of block boundary faults, a continuous deformation model explains the crustal deformation in the study area. The calculated minimum value of strike-slip displacement associated with this deformation detected within the shear zone is 210 m. The sum of this and offset on the Enako fault is 360 m and the slip rate is estimated at 0.6 mm/year.

  18. Long-Period Ground Motion Prediction Equations for Relative, Pseudo-Relative and Absolute Velocity Response Spectra in Japan

    Science.gov (United States)

    Dhakal, Y. P.; Kunugi, T.; Suzuki, W.; Aoi, S.

    2014-12-01

    Many of the empirical ground motion prediction equations (GMPE) also known as attenuation relations have been developed for absolute acceleration or pseudo relative velocity response spectra. For a small damping, pseudo and absolute acceleration response spectra are nearly identical and hence interchangeable. It is generally known that the relative and pseudo relative velocity response spectra differ considerably at very short or very long periods, and the two are often considered similar at intermediate periods. However, observations show that the period range at which the two spectra become comparable is different from site to site. Also, the relationship of the above two types of velocity response spectra with absolute velocity response spectra are not discussed well in literature. The absolute velocity response spectra are the peak values of time histories obtained by adding the ground velocities to relative velocity response time histories at individual natural periods. There exists many tall buildings on huge and deep sedimentary basins such as the Kanto basin, and the number of such buildings is growing. Recently, Japan Meteorological Agency (JMA) has proposed four classes of long-period ground motion intensity (http://www.data.jma.go.jp/svd/eew/data/ltpgm/) based on absolute velocity response spectra, which correlate to the difficulty of movement of people in tall buildings. As the researchers are using various types of response spectra for long-period ground motions, it is important to understand the relationships between them to take appropriate measures for disaster prevention applications. In this paper, we, therefore, obtain and discuss the empirical attenuation relationships using the same functional forms for the three types of velocity response spectra computed from observed strong motion records from moderate to large earthquakes in relation to JMA magnitude, hypocentral distance, sediment depths, and AVS30 as predictor variables at periods between

  19. A Preliminary Analysis on Empirical Attenuation of Absolute Velocity Response Spectra (1 to 10s) in Japan

    Science.gov (United States)

    Dhakal, Y. P.; Kunugi, T.; Suzuki, W.; Aoi, S.

    2013-12-01

    The Mw 9.1 Tohoku-oki earthquake caused strong shakings of super high rise and high rise buildings constructed on deep sedimentary basins in Japan. Many people felt difficulty in moving inside the high rise buildings even on the Osaka basin located at distances as far as 800 km from the epicentral area. Several empirical equations are proposed to estimate the peak ground motions and absolute acceleration response spectra applicable mainly within 300 to 500km from the source area. On the other hand, Japan Meteorological Agency has recently proposed four classes of absolute velocity response spectra as suitable indices to qualitatively describe the intensity of long-period ground motions based on the observed earthquake records, human experiences, and actual damages that occurred in the high rise and super high rise buildings. The empirical prediction equations have been used in disaster mitigation planning as well as earthquake early warning. In this study, we discuss the results of our preliminary analysis on attenuation relation of absolute velocity response spectra calculated from the observed strong motion records including those from the Mw 9.1 Tohoku-oki earthquake using simple regression models with various model parameters. We used earthquakes, having Mw 6.5 or greater, and focal depths shallower than 50km, which occurred in and around Japanese archipelago. We selected those earthquakes for which the good quality records are available over 50 observation sites combined from K-NET and KiK-net. After a visual inspection on approximately 21,000 three component records from 36 earthquakes, we used about 15,000 good quality records in the period range of 1 to 10s within the hypocentral distance (R) of 800km. We performed regression analyses assuming the following five regression models. (1) log10Y (T) = c+ aMw - log10R - bR (2) log10Y (T) = c+ aMw - log10R - bR +gS (3) log10Y (T) = c+ aMw - log10R - bR + hD (4) log10Y (T) = c+ aMw - log10R - bR +gS +hD (5) log10Y

  20. Stigma in response to mental disorders: a comparison of Australia and Japan

    Directory of Open Access Journals (Sweden)

    Jorm Anthony F

    2006-05-01

    Full Text Available Abstract Background There are few national or cross-cultural studies of the stigma associated with mental disorders. Australia and Japan have different systems of psychiatric health care, and distinct differences in cultural values, but enjoy similar standards of living. This study seeks to compare the nature and extent of stigma among the public in the two countries. Methods A household survey of the public was conducted in each country using similar methodologies. The Australian study comprised a national survey of 3998 adults aged over 18 years. The Japanese survey involved 2000 adults aged 20 to 69 from 25 regional sites distributed across the country. Interviewees reported their personal attitudes (personal stigma, social distance and perceptions of the attitudes of others (perceived stigma, perceived discrimination in the community with respect to four case vignettes. These vignettes described a person with: depression; depression with suicidal ideation; early schizophrenia; and chronic schizophrenia. Results Personal stigma and social distance were typically greater among the Japanese than the Australian public whereas the reverse was true with respect to the perception of the attitudes and discriminatory behaviour of others. In both countries, personal stigma was significantly greater than perceived stigma. The public in both countries showed evidence of greater social distance, greater personal stigma and greater perceived stigma for schizophrenia (particularly in its chronic form than for depression. There was little evidence of a difference in stigma for depression with and without suicide for either country. However, social distance was greater for chronic compared to early schizophrenia for the Australian public. Conclusion Stigmatising attitudes were common in both countries, but negative attitudes were greater among the Japanese than the Australian public. The results suggest that there is a need to implement national public

  1. Platelets as Central Mediators of Systemic Inflammatory Responses

    OpenAIRE

    Smith, Tammy L; Weyrich, Andrew S.

    2010-01-01

    Systemic inflammatory responses are associated with high morbidity and mortality and represent a diverse and clinically challenging group of diseases. Platelets are increasingly linked to inflammation, in addition to their well-known roles in hemostasis and thrombosis. There is agreement that traditional functions of platelets, including adherence, aggregation, and secretion of preformed mediators, contribute to systemic inflammatory responses. However, emerging evidence indicates that platel...

  2. Roles of National and Local Governments and the Dietetic Association in Nutrition Assistance Response to Natural Disasters: Systems and Experiences in Japan and the USA.

    Science.gov (United States)

    Sudo, Noriko

    2015-01-01

    In the first half of this symposium, the disaster response system in Japan will be introduced. The ultimate aim of nutrition assistance is to keep people in disaster areas healthy. This is a task for the Ministry of Health, Labour and Welfare and the health departments of prefectural governments. Our first speaker, Dr. Yasuhiro Kanatani, National Institute of Public Health, will briefly overview the disaster response system in Japan and its related laws. He will also mention how the Ministry responded to the Great East Japan Earthquake. In the second presentation, I will play one chapter of DVD that we released in last September. In that chapter, Ms. Makiko Sawaguchi, a registered dietitian working for a public health center in the area affected by the Great East Japan Earthquake, talks about her experience in supporting disaster victims. As an employee of Iwate Prefectural Government, she helped affected municipal governments and coordinated outside support. One type of outside support was registered dietitians dispatched by the Japan Dietetic Association (JDA). Dr. Nobuyo Tsuboyama-Kasaoka will report what those dietitians did in the affected areas. She will also explain the aim and training of the JDA-Disaster Assistance Team. Provision of food is essential in nutrition assistance. This is a task for the Ministry of Agriculture, Forestry and Fisheries. Our fourth speaker, Mr. Kunihiro Doi, analyzed the government procurement data and will discuss the limitations of government emergency food supplies and lessons learned from the Great East Japan Earthquake. As for the systems and experiences in the US, we invited Ms. Toni Abernathy from the Office of Emergency Management, Food and Nutrition Service (FNS), United States Department of Agriculture.

  3. Spatial Upscaling of Soil Respiration under a Complex Canopy Structure in an Old‐Growth Deciduous Forest, Central Japan

    Directory of Open Access Journals (Sweden)

    Vilanee Suchewaboripont

    2017-01-01

    Full Text Available The structural complexity, especially canopy and gap structure, of old‐growth forests affects the spatial variation of soil respiration (Rs. Without considering this variation, the upscaling of Rs from field measurements to the forest site will be biased. The present study examined responses of Rs to soil temperature (Ts and water content (W in canopy and gap areas, developed the best fit modelof Rs and used the unique spatial patterns of Rs and crown closure to upscale chamber measurements to the site scale in an old‐growth beech‐oak forest. Rs increased with an increase in Ts in both gap and canopy areas, but the effect of W on Rs was different between the two areas. The generalized linear model (GLM analysis identified that an empirical model of Rs with thecoupling of Ts and W was better than an exponential model of Rs with only Ts. Moreover, because of different responses of Rs to W between canopy and gap areas, it was necessary to estimate Rs in these areas separately. Consequently, combining the spatial patterns of Rs and the crown closure could allow upscaling of Rs from chamber‐based measurements to the whole site in the present study.

  4. Neonatal maturation of the hypercapnic ventilatory response and central neural CO2 chemosensitivity.

    Science.gov (United States)

    Putnam, Robert W; Conrad, Susan C; Gdovin, M J; Erlichman, Joseph S; Leiter, J C

    2005-11-15

    The ventilatory response to CO2 changes as a function of neonatal development. In rats, a ventilatory response to CO2 is present in the first 5 days of life, but this ventilatory response to CO2 wanes and reaches its lowest point around postnatal day 8. Subsequently, the ventilatory response to CO2 rises towards adult levels. Similar patterns in the ventilatory response to CO2 are seen in some other species, although some animals do not exhibit all of these phases. Different developmental patterns of the ventilatory response to CO2 may be related to the state of development of the animal at birth. The triphasic pattern of responsiveness (early decline, a nadir, and subsequent achievement of adult levels of responsiveness) may arise from the development of several processes, including central neural mechanisms, gas exchange, the neuromuscular junction, respiratory muscles and respiratory mechanics. We only discuss central neural mechanisms here, including altered CO2 sensitivity of neurons among the various sites of central CO2 chemosensitivity, changes in astrocytic function during development, the maturation of electrical and chemical synaptic mechanisms (both inhibitory and excitatory mechanisms) or changes in the integration of chemosensory information originating from peripheral and multiple central CO2 chemosensory sites. Among these central processes, the maturation of synaptic mechanisms seems most important and the relative maturation of synaptic processes may also determine how plastic the response to CO2 is at any particular age.

  5. Characterized Fault Model of Scenario Earthquake Caused by the Itoigawa-Shizuoka Tectonic Line Fault Zone in Central Japan and Strong Ground Motion Prediction

    Science.gov (United States)

    Sato, T.; Dan, K.; Irikura, K.; Furumura, M.

    2001-12-01

    Based on the existing ideas on characterizing complex fault rupture process, we constructed four different characterized fault models for predicting strong motions from the most likely scenario earthquake along the active fault zone of the Itoigawa-Shizuoka Tectonic Line in central Japan. The Headquarters for Earthquake Research Promotion in Japanese government (2001) estimated that the earthquake (8 +/- 0.5) has the total fault length of 112 km with four segments. We assumed that the characterized fault model consisted of two regions: asperity and background (Somerville et al., 1999; Irikura, 2000; Dan et al., 2000). The main differences in the four fault models were 1) how to determine a seismic moment Mo from a fault rupture area S, 2) number of asperities N, 3) how to determine a stress parameter σ , and 4) fmax. We calculated broadband strong motions at three stations near the fault by a hybrid method of the semi-empirical and theoretical approaches. A comparison between the results from the hybrid method and those from empirical attenuation relations showed that the hybrid method using the characterized fault model could evaluate near-fault rupture directivity effects more reliably than the empirical attenuation relations. We also discussed the characterized fault models and the strong motion characteristics. The Mo extrapolated from the empirical Mo-S relation by Somerville et al. (1999) was a half of that determined from the mean value of the Wells and Coppersmith (1994) data. The latter Mo was consistent with that for the 1891 Nobi, Japan, earthquake whose fault length was almost the same as the length of the target earthquake. In addition, the fault model using the latter Mo produced a slip amount of about 6 m on the largest asperity, which was consistent with the displacement of 6 m to 9 m per event obtained from a trench survey. High-frequency strong motions were greatly influenced by the σ for the asperities (188 bars, 246 bars, 108 bars, and 134

  6. Regulation of Neurotransmitter Responses in the Central Nervous System

    Science.gov (United States)

    1990-02-05

    accordance with DoD 5200.1 -R, Information Security Program Regulation. Chapter V1 Section 2, V"-apaph 4-200. clasification markings are to be stamped...through pharmacologically distinct reports. Finally, the augmenting response does not appear to be mediated through protein kinase C. However, BAC...may facilitate second messenger production by altering the coupling of catecholamine receptor to C- proteins involved in the cAMP cascade. (( ( CONTRACT

  7. Contrasting responses of Central Asian rock glaciers to global warming

    OpenAIRE

    Annina Sorg; Andreas Kääb; Andrea Roesch; Christof Bigler; Markus Stoffel

    2015-01-01

    While the responses of Tien Shan glaciers – and glaciers elsewhere – to climatic changes are becoming increasingly well understood, this is less the case for permafrost in general and for rock glaciers in particular. We use a novel approach to describe the climate sensitivity of rock glaciers and to reconstruct periods of high and low rock glacier activity in the Tien Shan since 1895. Using more than 1500 growth anomalies from 280 trees growing on rock glacier bodies, repeat aerial photograph...

  8. Policy responses to HIV/AIDS in Central Asia.

    Science.gov (United States)

    Ancker, Svetlana; Rechel, Bernd

    2015-01-01

    The countries of Central Asia (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) are confronted with one of the fastest growing HIV/AIDS epidemics worldwide, largely driven through injecting drug use. This article, based on a review of academic and grey literature, explores how they have responded. We find major similarities and differences across the region. At one extreme is Turkmenistan, which denies that there is any problem, does not offer harm reduction services or HIV/AIDS treatment and does not report any meaningful data to the international community. Uzbekistan is also pretty closed to outside influences, has discontinued its opioid substitution project and shares with Turkmenistan the legal prohibition of male-to-male sex. Kyrgyzstan originally led many progressive approaches in the region and, like neighbouring Tajikistan, has received substantial assistance by international agencies, in particular the Global Fund. Kazakhstan, with a much higher gross domestic product per capita, has taken on the financing of harm reduction activities through its national budget and has liberalised its drug policies. Yet, across the region punitive approaches to injecting drug use and people living with HIV/AIDS persist as do stigma and discrimination, while coverage with harm reduction programmes and treatment services is still low although with substantial variation across countries.

  9. Responses and Results to Ethical Problems by Psychiatric Nurses in Japan.

    Science.gov (United States)

    Ando, Michiyo; Kawano, Masashi

    2016-10-01

    The aim of this study was to investigate the responses of Japanese psychiatric nurses to ethical problems, and the results of those issues. The participants were 130 nurses who worked in psychiatry wards in a hospital. The nurses answered the question "how did you respond when you faced an ethical problem and what results did you get?" in free description. Seven categories were selected qualitatively from their responses: "Lack of action and no change," "Experiencing problems and feeling gloomy," "Pointing out misconduct and being hurt," "Consultation among staff and resolution or not," "Consultation with physicians and getting positive or negative responses," and "Searching for and providing evidence-based care," and "Thinking for themselves." The facts that some nurses do not cope with ethical problems and some face moral distress without knowing what to do suggest that "improvement of moral efficacy to cope with ethical problems", "proposing resolution methods", and "organizational ethics support" may be useful.

  10. Calcareous nannofossil biostratigraphy and geochronology of Neogene trench-slope cover sediments in the south Boso Peninsula, central Japan: Implications for the development of a shallow accretionary complex

    Science.gov (United States)

    Chiyonobu, Shun; Yamamoto, Yuzuru; Saito, Saneatsu

    2017-07-01

    The geological structure and calcareous nannofossil biostratigraphy of the Middle to Late Miocene trench-slope succession in the southern Boso Peninsula, central Japan, were examined to obtain chronological constraints on the accretion and formation of the trench-slope architecture. As a result, trench-slope cover sediments (Kinone and Amatsu Formations) are clearly distinguishable from the Early Miocene Hota accretionary complex (Hota Group). The Hota accretionary complex was deposited below the carbonate compensation depth (CCD) and was affected by intense shearing, forming an east-west trending and south-verging fold and thrust belt. In contrast, the trench-slope cover sediments basically have a homoclinal dip, except at the northern rim where they are bounded by fault contact. They contain many species of calcareous nannofossils and foraminifers, which are indicative of their depositional environment above the CCD, and they show shallowing-upward sedimentary structures. Biostratigraphy revealed that the depositional age of the trench-slope sediments is ca. 15-5.5 Ma, suggesting that there is an approximately 2 myr hiatus beween the Miura Group and the underlying accretionary prism. Based on these results, the age of accretion of the Hota Group is inferred to be between ca. 17-15 Ma, and the group is covered by trench-slope sediments overlain on it after ca. 15 Ma. The timing of accretion and the age of the trench-slope basin tend to be younger southward of the Boso Peninsula. The accretionary system of the Boso Peninsula apparently developed in two stages, in the Middle Miocene and in the Late Miocene to Pliocene.

  11. Event sand layers suggesting the possibility of tsunami deposits identified in the upper Holocene sequence nearby the Kuwana fault, central Japan

    Science.gov (United States)

    Niwa, Y.; Sugai, T.; Matsuzaki, H.

    2012-12-01

    The Kuwana fault is located on coastal area situated on inner part of the Ise Bay, central Japan, which opens to the Nankai Trough. This reverse fault displaces a late Pleistocene terrace surface with 1 to 2 mm/yr of average vertical slip rate, and a topset of delta at several meters, respectively. And, this fault is estimated to have generated two historical earthquakes (the AD 745 Tempyo and the AD 1586 Tensho earthquakes). We identified two event sand layers from upper Holocene sequence on the upthrown side of the Kuwana fault. Upper Holocene deposits in this study area show prograding delta sequence; prodelta mud, delta front sandy silt to sand, and flood plain sand/mud, respectively, from lower to upper. Two sand layers intervene in delta front sandy silt layer, respectively. Lower sand layer (S1) shows upward-coarsening succession, whereas upper sand layer (S2) upward-fining succession. These sand layers contain sharp contact, rip-up crust, and shell fragment, indicating strong stream flow. Radiocarbon ages show that these strong stream flow events occurred between 3000 and 1600 years ago. Decreasing of salinity is estimated from decreasing trend of electrical conductivity (EC) across S1. Based on the possibility that decreasing of salinity can be occurred by shallowing of water depth caused by coseismic uplift, and that S1 can be correlated with previously known faulting event on the Kuwana fault, S1 is considered to be tsunami deposits caused by faulting on the Kuwana fault. On the other hand, S2, which cannot be correlated with previously known faulting events on the Kuwana fault, may be tsunami deposits by ocean-trench earthquake or storm deposits. In the presentation, we will discuss more detail correlation of these sand deposits not only in the upthrown side of the Kuwana fault, but also downthrown side of the fault.

  12. An extremely large magnitude eruption close to the Plio-Pleistocene boundary: reconstruction of eruptive style and history of the Ebisutoge-Fukuda tephra, central Japan

    Science.gov (United States)

    Kataoka, K.; Nagahashi, Y.; Yoshikawa, S.

    2001-06-01

    An extremely large magnitude eruption of the Ebisutoge-Fukuda tephra, close to the Plio-Pleistocene boundary, central Japan, spread volcanic materials widely more than 290,000 km 2 reaching more than 300 km from the probable source. Characteristics of the distal air-fall ash (>150 km away from the vent) and proximal pyroclastic deposits are clarified to constrain the eruptive style, history, and magnitude of the Ebisutoge-Fukuda eruption. Eruptive history had five phases. Phase 1 is phreatoplinian eruption producing >105 km 3 of volcanic materials. Phases 2 and 3 are plinian eruption and transition to pyroclastic flow. Plinian activity also occurred in phase 4, which ejected conspicuous obsidian fragments to the distal locations. In phase 5, collapse of eruption column triggered by phase 4, generated large pyroclastic flow in all directions and resulted in more than 250-350 km 3 of deposits. Thus, the total volume of this tephra amounts over 380-490 km 3. This indicates that the Volcanic Explosivity Index (VEI) of the Ebisutoge-Fukuda tephra is greater than 7. The huge thickness of reworked volcaniclastic deposits overlying the fall units also attests to the tremendous volume of eruptive materials of this tephra. Numerous ancient tephra layers with large volume have been reported worldwide, but sources and eruptive history are often unknown and difficult to determine. Comparison of distal air-fall ashes with proximal pyroclastic deposits revealed eruption style, history and magnitude of the Ebisutoge-Fukuda tephra. Hence, recognition of the Ebisutoge-Fukuda tephra, is useful for understanding the volcanic activity during the Pliocene to Pleistocene, is important as a boundary marker bed, and can be used to interpret the global environmental and climatic impact of large magnitude eruptions in the past.

  13. Contrasting responses of Central Asian rock glaciers to global warming.

    Science.gov (United States)

    Sorg, Annina; Kääb, Andreas; Roesch, Andrea; Bigler, Christof; Stoffel, Markus

    2015-02-06

    While the responses of Tien Shan glaciers--and glaciers elsewhere--to climatic changes are becoming increasingly well understood, this is less the case for permafrost in general and for rock glaciers in particular. We use a novel approach to describe the climate sensitivity of rock glaciers and to reconstruct periods of high and low rock glacier activity in the Tien Shan since 1895. Using more than 1500 growth anomalies from 280 trees growing on rock glacier bodies, repeat aerial photography from Soviet archives and high-resolution satellite imagery, we present here the world's longest record of rock glacier movements. We also demonstrate that the rock glaciers exhibit synchronous periods of activity at decadal timescales. Despite the complex energy-balance processes on rock glaciers, periods of enhanced activity coincide with warm summers, and the annual mass balance of Tuyuksu glacier fluctuates asynchronously with rock glacier activity. At multi-decadal timescales, however, the investigated rock glaciers exhibit site-specific trends reflecting different stages of inactivation, seemingly in response to the strong increase in air temperature since the 1970s.

  14. Faszination Japan

    OpenAIRE

    Árokay, Judit

    2014-01-01

    Japan ist ein Ausnahmeland. Nach dem Zweiten Weltkrieg stieg Japan rasand schnell zu einer Wirtschaftsmacht auf, heute ist es das westlichste Land im Fernen Osten. Über das Leben im modernen Japan sowie über Einschätzungen und Fehleinschätzungen dieses faszinierenden Landes in Deutschland sprach der Campus-Reporter Nils Birschmann mit der Professorin für Japanologie an der Universität Heidelberg, Frau Prof. Dr. Judit Árokay. Der Beitrag "Faszination Japan" erschien in der Sendereihe "Camp...

  15. Fighting Brick with Brick: Chikazumi Jōkan and Buddhism’s Response to Christian Space in Imperial Japan

    Directory of Open Access Journals (Sweden)

    Garrett Washington

    2013-03-01

    Full Text Available In 1915, with the support of Jōdo Shinshū (True Pure Land Buddhism’s Higashi Honganji sect and dozens of private Buddhist donors, Buddhist priest Chikazumi Jōkan erected a new, one-of-a-kind Buddhist meeting hall in Tokyo, the Kyūdō Kaikan. Chikazumi conceived of the building as a clear and deliberate spatial challenge to the crowded Protestant churches and lecture halls of turn-of-the-twentieth-century Tokyo. He chose prominent Western-style architect Takeda Goichi (1872–1938, rather than a traditional Japanese shrine or temple carpenter, to design it. The new building, in tandem with the adjacent Kyūdō Gakusha (Salvation Dormitory that Chikazumi established in 1902, spoke to, and significantly impacted, the socio-moral, intellectual, and religious life of hundreds of young Tokyoites. These two buildings represented a response to Protestant Christianity’s popularity and relevance like no other in imperial Japan. In order to achieve the religious evangelism and suprasectarian reform that he envisioned for Buddhism, Chikazumi proved willing to apply observations made in the West and appropriate practical Western Christian architectural features. Through an analysis of drawings, photographs, periodicals, institutional records, and other sources, this article tells the story of the rare fusion of opposites as Chikazumi equipped Buddhism to compete with Protestantism for the attention and devotion of the educated elite.

  16. Update Japan.

    Science.gov (United States)

    Hoopes, Aaron

    This book is a guide intended for persons planning on relocating to Japan. Following a chapter on background information, 13 additional chapters lead the reader step-by-step through the relocation process. These chapters include: before leaving, on arrival, language, culture, doing business in Japan, household pointers and everyday life, schools…

  17. Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

    Directory of Open Access Journals (Sweden)

    Yi Zhao

    2016-01-01

    Full Text Available It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn. In fact, despite intricate internal neuroplasticity and diverse external symptoms, several classical injury models provide a feasible path to locate responses to different peripheral cochlear lesions. In these cases, hair cell damage may lead to considerable hyperactivity in the central auditory pathways, mediated by a reduction in inhibition, which may underlie some clinical symptoms associated with hearing loss, such as tinnitus. Homeostatic plasticity, the most discussed and acknowledged mechanism in recent years, is most likely responsible for excited central activity following cochlear damage.

  18. Seasonal variations of {sup 14}C and δ{sup 13}C for cave drip waters in Ryugashi Cave, Shizuoka Prefecture, central Japan

    Energy Technology Data Exchange (ETDEWEB)

    Minami, Masayo, E-mail: minami@nendai.nagoya-u.ac.jp [Center for Chronological Research, Nagoya University, Nagoya 464-8602 (Japan); Kato, Tomomi [Graduate School of Environmental Studies, Nagoya University, Nagoya 464-8601 (Japan); Horikawa, Keiji [Department of Environmental Biology and Chemistry, Toyama University, Toyama 930-8555 (Japan); Nakamura, Toshio [Center for Chronological Research, Nagoya University, Nagoya 464-8602 (Japan)

    2015-11-01

    Speleothem {sup 14}C has recently emerged as a potentially powerful proxy for hydrology changes in comparison with atmospheric {sup 14}C calibration curve, rather than as a direct dating tool, apart from a time marker using bomb peak of {sup 14}C. Some possible causes for the relationship between speleothem {sup 14}C content (or dead carbon fraction: DCF) and karst hydrology have been proposed, such as changes in temperature, precipitation, drip water flow dynamics, cave air ventilation, soil air pCO{sub 2}. In this study, we investigated seasonal variation in {sup 14}C and δ{sup 13}C of drip water in Ryugashi Cave, Shizuoka Prefecture, central Japan, to examine the causes of the {sup 14}C and δ{sup 13}C variations in a speleothem. The results show that different {sup 14}C concentrations and δ{sup 13}C values of drip water from the Ryugashi Cave, were exhibited at different sites of the Caves No. 1, No. 3, and No. 4, which have different temperature, air pCO{sub 2}, and flow paths. Further, the {sup 14}C and δ{sup 13}C of drip waters showed seasonal variations at all sites, which were lower in fall and winter, and higher in spring and summer, though the extent of the variations was different among the sites. The {sup 14}C in drip waters tended to be correlated with the drip rates: {sup 14}C tended to be higher in drip waters with higher drip rates, and also correlated with rainfall amount around the Ryugashi Cave, especially for the drip waters in Cave No. 3, which are considered to have simpler flow paths. The increase in rainfall amount could bring the increase in drip rate of drip water, and then the decrease in interaction between solution and karst, resulting in {sup 14}C increase (DCF decrease) in drip water. Accordingly, the reconstruction of precipitation could be performed using {sup 14}C variation in a speleothem formed by drip water with simple flow dynamics.

  19. Responses of Manila clam growth and its food sources to global warming in a subarctic lagoon in Japan

    Science.gov (United States)

    Yoon, Seokjin; Abe, Hiroya; Kishi, Michio J.

    2013-12-01

    Akkeshi Lake is a subarctic shallow brackish lagoon located in Hokkaido, Japan. The Manila clam, Ruditapes philippinarum, is cultured in sandy sediments at the shallow, intertidal flat near the mouth of the lake. To quantitatively evaluate the effects of environmental factors such as water temperature and food availability on the growth of the Manila clam and to estimate the responses of Manila clam growth and food availability to global warming in Akkeshi Lake, we developed a numerical model by coupling a three-dimensional ecosystem model with a bioenergetics model for the growth of the Manila clam. We ran the model under two different conditions: the present condition and the global warming condition. For the global warming condition, water temperature was increased by 2 °C at the open boundary for the entire computational period. The growth of the Manila clam was limited by water temperature and food availability. The Manila clam grew up to 1.33 g dry weight ind.-1 at the lake mouth (station A) for 5 years, whereas it grew up to 1.00 g dry weight ind.-1 at the lake center (station B). The difference in the biomass of the Manila clam between two stations was due to the difference in food availability. Under the global warming condition, the water temperature limitation for the Manila clam was relaxed with a water temperature increase. The Manila clam grew up to 1.55 g dry weight ind.-1 at station A and 1.10 g dry weight ind.-1 at station B. While the growth of the Manila clam was improved in the lake under the global warming condition, its food sources, especially phytoplankton, decreased because of ingestion increases of grazers.

  20. IS SOCIAL RESPONSIBILITY CONSIDERS A FUNCTION OF LATIN AMERICAN CENTRAL BANKS?

    Directory of Open Access Journals (Sweden)

    Rosa Elena Carrera Pedroza

    2013-07-01

    Full Text Available The main purpose was to research whether social responsibility is considered a function of Latin American Central Banks. It focused on a qualitative and quantitative model, with epistemological base centered on phenomenology, a type of methodological approach that uses a feasible project and design field. From a statistical probabilistic procedure, a sample of nine Latin American Central banks was selected. For data collection, a questionnaire was applied, which revealed that 78% have education programs designed to train and disseminate economic knowledge, 56% takes social responsibility activities, while 44% makes grants to third parties.

  1. Rearming Japan

    Science.gov (United States)

    2007-11-02

    roughly ~’ Ibid., pp. 14-16, 27-30. 12 3.5 percent of their GDP towards defense while Japan spends slightly over 1 percent. Yet, when compared with...runs up huge trade surpluses in its commerce with the United States and Western Europe. Conversely, Japan spends just slightly over one percent of...its GNP on defense indicating to many in the U.S. and Western Europe that Japan is enjoying a free ride and waxing rich under American military

  2. Benthic Biotic Response to Climate Changes over the Last 700,000 Years, the Sea of Japan: Ostracode Assemblages from Site U1427, IODP Expedition 346

    Science.gov (United States)

    Huang, H. H. M.; Yasuhara, M.; Iwatani, H.; Alvarez Zarikian, C. A.; Bassetti, M. A.; Sagawa, T.

    2016-12-01

    The Sea of Japan is a marginal sea, semi-enclosed by the Eurasian Continent, Korean Peninsula, Japanese Islands, and shallow straits (water depth formed 1.7 My ago by tectonic subsidence of the Tsushima Strait. The Sea of Japan, therefore, is an interesting research subject for studying the biotic response to orbital-scale climate changes and benthic faunal development under the influence of TWC. Here we present 700,000-year record of benthic biotic response to the paleoceanographic changes in the southern Sea of Japan based on ostracode assemblage reconstruction at IODP Site U1427. Five local extinction events were caused by extreme bottom conditions (mainly oxygen depletion) during the Ice Age Terminations I, II, IV, V, and VII. Primary and secondary ostracode assemblages were revealed by Q-mode k-means clustering, CABFAC factor analysis, and non-metric multidimensional scaling. The primary ostracode components, characterized by Krithe sawanensis and Cytheropteron hyalinosa, broadly reflect glacial/interglacial and high-latitude insolation cycles. In contrast, a faunal shift determined by the secondary faunal components was driven by the TWC enhancement at 300 ka.

  3. Higher Education Studies in Japan

    Science.gov (United States)

    Kaneko, Motohisa

    2010-01-01

    The rapid development of higher education in the postwar period has given rise to various problems, and higher education studies in Japan have developed in response to them. What have been the major issues, and how did academic research respond to them, in postwar Japan? This article delineates an outline of higher education studies in general,…

  4. Central Banks’ Response to the Current Financial Crisis – Between Costs and Benefits

    Directory of Open Access Journals (Sweden)

    Teodora Cristina Barbu

    2012-01-01

    Full Text Available Our study is inserted in the thematic area dedicated, during recent years, to the research on central banks’ response to financial crisis. The global financial crisis has outlined a series of weaknesses located at regulatory and supervisory activities’ level, causing major central banks to face a new operating environment, in which traditional monetary policy tools are ineffective (key interest rate close to zero in restoring the financial markets’ proper functioning. The unconventional monetary policy measures, the dramatic fall of the key interest rate, the balance sheet structure modification and extension of collateral accepted by central banks are the main issues on which we focused our attention, to highlight the costs and benefits recorded by these institutions. All major central banks have implemented highly innovative, flexible facilities and the main beneficiaries have been the banking systems in their entirety.

  5. Networking Japan

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    Human Resource Development was the first and remains an important pillar in Japanese foreign aid. I will argue that Japan has access to a global network of alumni who will co-define Japanese foreign aid in the future, because Japan has encouraged alumni societies and networking since 1965. A total...... of more than a million people in more than 100 countries have attended courses in Japan funded fully or partly by Japanese ODA since the inception of the technical assistance programs in 1954 through the Colombo Plan and since 1959 through the Association of Overseas Technical Scholarships (AOTS from 2009...... HIDA). Many of these alumni have and will in the future exchange ideas and keep contact not only to Japan, but also to fellow alumni around the globe and, thereby, practice south-south exchanges, which are made possible and traceable by their established alumni network and the World Network of Friends...

  6. A framework for assessing climate change vulnerability and identifying adaptation responses in the central hardwoods region

    Science.gov (United States)

    Patricia R. Butler; Leslie A. Brandt; Stephen D. Handler; Maria K. Janowiak; Patricia D. Shannon; Chris W. Swanston

    2014-01-01

    The Central Hardwood region contains a mosaic of forests, woodlands, savannas, and other ecosystems that will increasingly be affected by a changing climate over the next century. Understanding potential impacts is important to sustaining healthy forests under changing conditions. The objectives of the Climate Change Response Framework (forestadaptation.org) are to...

  7. Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response

    Directory of Open Access Journals (Sweden)

    Jennifer M. Rojas

    2015-08-01

    Conclusions: The effect of acute inhibition of central FGFR signaling to impair glucose tolerance likely involves a stress response associated with pronounced, but transient, sympathoadrenal activation and an associated reduction of insulin secretion. Whether this effect is a true consequence of FGFR blockade or involves an off-target effect of the FGFR inhibitor requires additional study.

  8. An inter-religious humanitarian response in the Central African Republic

    Directory of Open Access Journals (Sweden)

    Catherine Mahony

    2014-11-01

    Full Text Available Inter-religious action has played a key role in ensuring that social cohesion and inter-religious mediation remain on the international agenda in relation to response in the Central African Republic, where people’s faith is an integral part of their identity but where it has been manipulated in a horrific way.

  9. The Bilateral and Multilateral Relationship between Central Asia and Japan, and the Enlightenment on China%中亚-日本双边、多边关系及其对中国的启示

    Institute of Scientific and Technical Information of China (English)

    玉素甫·阿布来提

    2014-01-01

    Since the Middle Asian countries established diplomatic relations with Japan, the bilateral partnership began to develop steadily with the increasing ofifcial contacts. In 1997 the“Silk Road”Diplomacy concept revealed Japan’s policy toward Central Asia. In the beginning of 21st century, new partners were mainly welcomed in the region. During the two decades the partnership between Central Asian nations and Japan began to increase steadily, including cooperation in education, economic development of the region, political reforms, as well as energy resources. Japan's effort in creating the“Central Asia plus Japan”dialogue is part of its multilateral diplomacy. Building the conception of“Silk Road Economic Belt”demonstrates the importance the Chinese leaders attach on Central Asia policy, relfecting China’s strategy in Central Asia. Japan’s Central Asian policy may cause some negative inlfuence to China. Therefore, the policy should be positively handled, but not be regarded as a policy to restrain China. There might be some enlightenment to China.%中亚各国与日本建立外交关系以来,随着官方交往水平的提高,其伙伴关系稳步发展。1997年,“新丝路外交”这一概念总结了日本的中亚政策。21世纪伊始,新的地区伙伴开始受到中亚的欢迎。20多年间,日本与中亚的合作突出了几个特别的领域,即教育、区域经济发展、政治改革以及能源资源,其多边外交关系提升到了建立“中亚+日本”的对话机制。构建“丝绸之路经济带”的构想,反映了中国领导人对中亚政策的重要体现,反映了中国的中亚战略。日本的中亚政策,会在一定程度上给中国与中亚国家合作关系的发展造成一些影响,但是不能看作遏制中国与中亚国家合作关系的政策,应从中获得一定的启示。

  10. Biogeochemistry of plant-soil system in a limestone area: A case study of Mt. Kinsho-zan, Gifu prefecture, central Japan

    Science.gov (United States)

    Ueno, S.; Sugitani, K.; Ono, M.

    2010-12-01

    Limestone contains few of the nutrients essential for plant growth, such as Si, K, and P. Owing to its high concentrations of alkali earth elements and the resulting high pH, P and Fe tend to be sparingly available for plants in soils developed in limestone areas. Because of this limited availability of nutrients in calcareous soils, certain typical calcareous plants are known to occasionally dominate. On Mt. Kinsho-zan, a limestone mountain in Gifu prefecture, central Japan, however, typical calcareous plants are not seen; various non-calcareous plants appear and do not seem to be malnourished. In addition to the nutrients supplied by precipitation and eolian dusts, litter decomposition may supply nutrients, which could circulate in the plant-soil system. In this study, the soil properties (water content, loss on ignition, and pH) and the chemical compositions of soils, plant leaves (Chamaecyparis obtusa), and parental rocks (limestone) were analyzed to clarify the biogeochemical cycle of the plant-soil system on Mt. Kinsho-zan. A mountain composed of sandstone and mudstone, which lies near the main research area, was chosen for comparison. Chemical compositions were analyzed using an X-ray fluorescence spectrometer (Spectris Co., Ltd Panalytical Division Axios-N system). Ten major elements were analyzed in all samples, and 13 and 4 trace elements were analyzed for soils and plants and for limestones, respectively. In the limestone samples, the concentrations were as follows: SiO2 = 0.12-0.22wt%, Al2O3 = 0.054-0.13wt%, Fe2O3 = 0.021-0.057wt%, CaO = 55.12-55.33wt%, K2O = 40-55 ppm, TiO2 = 29-48 ppm, and Zr = 12-14 ppm. In soils developed in the limestone area, SiO2 = 43.48-55.46wt%, Al2O3 = 25.47-34.92wt%, Fe2O3 = 10.75-13.64wt%, CaO = 0.46-5.61wt%, K2O = 1.30-1.72wt%, TiO2 = 1.02-1.36wt%, and Zr = 240-319 ppm. Concentrations of Fe2O3, MnO, and P2O5 in soils from the limestone area are two times higher than those in soils from the sandstone-mudstone area; the

  11. Renal responses to central vascular expansion are suppressed at night in conscious primates

    Science.gov (United States)

    Kass, D. A.; Sulzman, F. M.; Fuller, C. A.; Moore-Ede, M. C.

    1980-01-01

    The renal and hemodynamic responses of squirrel monkeys to central vascular volume expansion induced by lower body positive pressure (LBPP) during the day and night are investigated. Twelve unanesthetized animals trained to sit in a metabolism chair in which they were restrained only at the waist by a partition separating upper and lower body chambers were subjected to 4 h of continuous LBPP during the day and night, and hemodynamic, urinary and drinking data were monitored. LBPP during day and night is found to induce similar increases in central venous pressure, rises in heart rate and elevations in mean arterial blood pressure. However, although daytime LBPP induced a significant increase in urine flow and sodium excretion, a marked nocturnal inhibition of the renal response to LBPP is observed. Analysis of the time course and circadian regulation patterns of the urinary responses suggests that several separate efferent control pathways are involved.

  12. IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis

    Science.gov (United States)

    Phares, Timothy W.; DiSano, Krista D.; Hinton, David R.; Hwang, Mihyun; Zajac, Allan J.; Stohlman, Stephen A.; Bergmann, Cornelia C.

    2013-01-01

    Acute coronavirus encephalomyelitis is controlled by T cells while humoral responses suppress virus persistence. This study defines the contribution of interleukin (IL)-21, a regulator of T and B cell function, to central nervous system (CNS) immunity. IL-21 receptor deficiency did not affect peripheral T cell activation or trafficking, but dampened granzyme B, gamma interferon and IL-10 expression by CNS T cells and reduced serum and intrathecal humoral responses. Viral control was already lost prior to humoral CNS responses, but demyelination remained comparable. These data demonstrate a critical role of IL-21 in regulating CNS immunity, sustaining viral persistence and preventing mortality. PMID:23992866

  13. Central Mechanisms Underlying Variability in the Behavioral and Neuroendocrine Responses to Stress in Fish

    DEFF Research Database (Denmark)

    Moltesen, Maria Møller

    of the stress response. In mammals, the hippocampus and amygdala in the telencephalon play central roles in the process of discriminating sensory inputs that, potentially, will threaten the homeostasis of an individual. These regions are part of the limbic system, which interacts with the hypothalamic....... The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) also plays an important role in the neuroendocrine stress response by controlling CRF release in hypothalamus. The transmission of 5-HT and CRF are under feedback control of glucocorticoids and interact with the stress response by affecting processes...

  14. Decreased vegetation growth in response to summer drought in Central Asia from 2000 to 2012

    Science.gov (United States)

    Xu, Hao-jie; Wang, Xin-ping; Zhang, Xiao-xiao

    2016-10-01

    Climate change scenarios predict that Central Asia may experience an increase in the frequency and magnitude of temperature and precipitation extremes by the end of the 21st century, but the response regularity of different types of vegetation to climate extremes is uncertain. Based on remote-sensed vegetation index and in-situ meteorological data for the period of 2000-2012, we examined the diverse responses of vegetation to climate mean/extremes and differentiated climatic and anthropogenic influence on the vegetation in Central Asia. Our results showed that extensive vegetation degradation was related to summer water deficit as a result of the combined effect of decreased precipitation and increased potential evapotranspiration. Water was a primary climatic driver for vegetation changes regionally, and human-induced changes in vegetation confined mainly to local areas. Responses of vegetation to water stress varied in different vegetation types. Grasslands were most responsive to water deficit followed by forests and desert vegetation. Climate extremes caused significant vegetation changes, and different vegetation types had diverse responses to climate extremes. Grasslands represented a symmetric response to wet and dry periods. Desert vegetation was more responsive during wet years than in dry years. Forests responded more strongly to dry than to wet years due to a severe drought occurred in 2008. This study has important implications for predicting how vegetation ecosystems in drylands respond to climate mean/extremes under future scenarios of climate change.

  15. Land surface phenological responses to land use and climate variation in a changing Central Asia

    Science.gov (United States)

    Kariyeva, Jahan

    During the last few decades Central Asia has experienced widespread changes in land cover and land use following the socio-economic and institutional transformations of the region catalyzed by the USSR collapse in 1991. The decade-long drought events and steadily increasing temperature regimes in the region came on top of these institutional transformations, affecting the long term and landscape scale vegetation responses. This research is based on the need to better understand the potential ecological and policy implications of climate variation and land use practices in the contexts of landscape-scale changes dynamics and variability patterns of land surface phenology responses in Central Asia. The land surface phenology responses -- the spatio-temporal dynamics of terrestrial vegetation derived from the remotely sensed data -- provide measurements linked to the timing of vegetation growth cycles (e.g., start of growing season) and total vegetation productivity over the growing season, which are used as a proxy for the assessment of effects of variations in environmental settings. Local and regional scale assessment of the before and after the USSR collapse vegetation response patterns in the natural and agricultural systems of the Central Asian drylands was conducted to characterize newly emerging links (since 1991) between coupled human and natural systems, e.g., socio-economic and policy drivers of altered land and water use and distribution patterns. Spatio-temporal patterns of bioclimatic responses were examined to determine how phenology is associated with temperature and precipitation in different land use types, including rainfed and irrigated agricultural types. Phenological models were developed to examine relationship between environmental drivers and effect of their altitudinal and latitudinal gradients on the broad-scale vegetation response patterns in non-cropland ecosystems of the desert, steppe, and mountainous regional landscapes of Central Asia

  16. Novel Genetic Variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale, and a Novel Ehrlichia sp. in Wild Deer and Ticks on Two Major Islands in Japan

    OpenAIRE

    Kawahara, Makoto; Rikihisa, Yasuko; Lin, Quan; Isogai, Emiko; Tahara, Kenji; Itagaki, Asao; Hiramitsu, Yoshimichi; Tajima, Tomoko

    2006-01-01

    Wild deer are one of the important natural reservoir hosts of several species of Ehrlichia and Anaplasma that cause human ehrlichiosis or anaplasmosis in the United States and Europe. The primary aim of the present study was to determine whether and what species of Ehrlichia and Anaplasma naturally infect deer in Japan. Blood samples obtained from wild deer on two major Japanese islands, Hokkaido and Honshu, were tested for the presence of Ehrlichia and Anaplasma by PCR assays and sequencing ...

  17. Non-linear buffeting response analysis of long-span suspension bridges with central buckle

    Science.gov (United States)

    Wang, Hao; Li, Aiqun; Zhao, Gengwen; Li, Jian

    2010-06-01

    The rigid central buckle employed in the Runyang Suspension Bridge (RSB) was the first time it was used in a suspension bridge in China. By using a spectral representation method and FFT technique combined with measured data, a 3D fluctuating wind field considering the tower wind effect is simulated. A novel FE model for buffeting analysis is then presented, in which a specific user-defined Matrix27 element in ANSYS is employed to simulate the aeroelastic forces and its stiffness or damping matrices are parameterized by wind velocity and vibration frequency. A nonlinear time history analysis is carried out to study the influence of the rigid central buckle on the wind-induced buffeting response of a long-span suspension bridge. The results can be used as a reference for wind resistance design of long-span suspension bridges with a rigid central buckle in the future.

  18. Musterland Japan?

    OpenAIRE

    Weidner, Helmut

    1990-01-01

    Im Gegensatz zu Japan ist in den westeuro­päischen Ländern die Umweltpolitik erst seit Beginn der achtziger Jahre in heftige Bewe­gung geraten. Den Anstoß hierzu gaben wie in Japan in den sechziger Jahren vor allem Umweltschadensfälle größeren Ausmaßes, wodurch Regierungen, Verwaltungen und umweltbelastende Betriebe unter starken Handlungsdruck gesetzt wurden. Seitdem gehören Umweltfragen in nahezu allen Indu­strieländern zu den zentralen politischen Themen. Trotz teilweise beeindrucken...

  19. Effects of food on the central and peripheral haemodynamic response to upright exercise in normal volunteers.

    OpenAIRE

    Yi, J. J.; Fullwood, L.; Stainer, K; Cowley, A. J.; Hampton, J R

    1990-01-01

    The central and peripheral haemodynamic effects of a modest meal were investigated in healthy volunteers at rest and in response to submaximal exercise. The meal increased heart rate, cardiac output, oxygen consumption, carbon dioxide production, and minute ventilation at rest and during exercise. The effects of food were additive to those induced by the exercise. Food had no effect on limb blood flow and lowered total systemic vascular resistance suggesting that there were no compensatory ch...

  20. Clinical features and early treatment response of central nervous system involvement in childhood acute lymphoblastic leukemia

    DEFF Research Database (Denmark)

    Levinsen, Mette; Taskinen, Mervi; Abrahamsson, Jonas

    2014-01-01

    BACKGROUND: Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) remains a therapeutic challenge. PROCEDURE: To explore leukemia characteristics of patients with CNS involvement at ALL diagnosis, we analyzed clinical features and early treatment response of 744...... leukemia and patients without such characteristics (0.50 vs. 0.61; P = 0.2). CONCLUSION: CNS involvement at diagnosis is associated with adverse prognostic features but does not indicate a less chemosensitive leukemia....

  1. Area of peripheral retinal nonperfusion and treatment response in branch and central retinal vein occlusion.

    Science.gov (United States)

    Singer, Michael; Tan, Colin S; Bell, Darren; Sadda, Srinivas R

    2014-09-01

    To evaluate the extent of peripheral retinal nonperfusion in retinal vein occlusion and to determine its effect on the severity of macular edema and response to treatment. This prospective clinic-based cohort study included 32 consecutive patients with retinal vein occlusion and refractory macular edema evaluated using spectral domain optical coherence tomography and wide-field fluorescein angiography. Areas of ischemia were calculated as a percentage of the total visible retina (ischemic index), which was evaluated when macular edema was present (foveal central subfield >300 μm) and when edema had resolved (foveal central subfield ≤ 300 μm). Ischemic index was the main outcome measure. The mean ischemic index at study enrollment was 14.8% and was larger when macular edema was present compared with when edema had resolved (14.8 vs. 10.3%, P 10% had thicker mean foveal central subfield on optical coherence tomography (520.8 vs. 424.5 μm, P = 0.029) and worse visual acuity (56.3 vs. 59 letters) with the presence of macular edema and experienced greater decrease in optical coherence tomography (296.1 vs. 165.3 μm, P = 0.019) and gain in visual acuity (12.4 vs. 0.9 letters, P = 0.036) in response to treatment. The area of peripheral retinal nonperfusion is variable in patients with retinal vein occlusion and affects its clinical course and response to treatment.

  2. Japan 2014

    DEFF Research Database (Denmark)

    Selmer, Finn

    2014-01-01

    In March 2014 a group of teachers and students from the Royal Danish Academy of Fine Arts Schools of Architecture, Design and Conservation, School of Architecture, Study Dept. 3 went on a study trip to Japan. This publication collects observations and reflections that the participants of the trip...

  3. Japan 2014

    DEFF Research Database (Denmark)

    Selmer, Finn

    2014-01-01

    In March 2014 a group of teachers and students from the Royal Danish Academy of Fine Arts Schools of Architecture, Design and Conservation, School of Architecture, Study Dept. 3 went on a study trip to Japan. This publication collects observations and reflections that the participants of the trip...

  4. Safety and effectiveness of tacrolimus add-on therapy for rheumatoid arthritis patients without an adequate response to biological disease-modifying anti-rheumatic drugs (DMARDs): Post-marketing surveillance in Japan.

    Science.gov (United States)

    Takeuchi, Tsutomu; Ishida, Kota; Shiraki, Katsuhisa; Yoshiyasu, Takashi

    2017-06-26

    Post-marketing surveillance (PMS) was conducted to assess the safety and effectiveness of tacrolimus (TAC) add-on therapy for patients with rheumatoid arthritis (RA) and an inadequate response to biological disease-modifying anti-rheumatic drugs (DMARDs). Patients with RA from 180 medical sites across Japan were registered centrally with an electronic investigation system. The observational period was 24 weeks from the first day of TAC administration concomitantly with biological DMARDs. Safety and effectiveness populations included 624 and 566 patients, respectively. Patients were predominantly female (81.1%), with a mean age of 61.9 years. Overall, 125 adverse drug reactions (ADRs) occurred in 94 patients (15.1%), and 15 serious ADRs occurred in 11 patients (1.8%). These incidences were lower compared with previously reported incidences after TAC treatment in PMS, and all of the observed ADRs were already known. A statistically significant improvement was observed in the primary effectiveness variable of Simplified Disease Activity Index after TAC treatment; 62.7% of patients achieved remission or low disease activity at week 24. TAC is well tolerated and effective when used as an add-on to biological DMARDs in Japanese patients with RA who do not achieve an adequate response to biological DMARDs in a real-world clinical setting.

  5. Central Appalachians forest ecosystem vulnerability assessment and synthesis: a report from the Central Appalachians Climate Change Response Framework project

    Science.gov (United States)

    Patricia R. Butler; Louis Iverson; Frank R. Thompson; Leslie Brandt; Stephen Handler; Maria Janowiak; P. Danielle Shannon; Chris Swanston; Kent Karriker; Jarel Bartig; Stephanie Connolly; William Dijak; Scott Bearer; Steve Blatt; Andrea Brandon; Elizabeth Byers; Cheryl Coon; Tim Culbreth; Jad Daly; Wade Dorsey; David Ede; Chris Euler; Neil Gillies; David M. Hix; Catherine Johnson; Latasha Lyte; Stephen Matthews; Dawn McCarthy; Dave Minney; Daniel Murphy; Claire O’Dea; Rachel Orwan; Matthew Peters; Anantha Prasad; Cotton Randall; Jason Reed; Cynthia Sandeno; Tom Schuler; Lesley Sneddon; Bill Stanley; Al Steele; Susan Stout; Randy Swaty; Jason Teets; Tim Tomon; Jim Vanderhorst; John Whatley; Nicholas. Zegre

    2015-01-01

    Forest ecosystems in the Central Appalachians will be affected directly and indirectly by a changing climate over the 21st century. This assessment evaluates the vulnerability of forest ecosystems in the Central Appalachian Broadleaf Forest-Coniferous Forest-Meadow and Eastern Broadleaf Forest Provinces of Ohio, West Virginia, and Maryland for a range of future...

  6. Central Hardwoods ecosystem vulnerability assessment and synthesis: a report from the Central Hardwoods Climate Change Response Framework project

    Science.gov (United States)

    Leslie Brandt; Hong He; Louis Iverson; Frank R. Thompson; Patricia Butler; Stephen Handler; Maria Janowiak; P. Danielle Shannon; Chris Swanston; Matthew Albrecht; Richard Blume-Weaver; Paul Deizman; John DePuy; William D. Dijak; Gary Dinkel; Songlin Fei; D. Todd Jones-Farrand; Michael Leahy; Stephen Matthews; Paul Nelson; Brad Oberle; Judi Perez; Matthew Peters; Anantha Prasad; Jeffrey E. Schneiderman; John Shuey; Adam B. Smith; Charles Studyvin; John M. Tirpak; Jeffery W. Walk; Wen J. Wang; Laura Watts; Dale Weigel; Steve. Westin

    2014-01-01

    The forests in the Central Hardwoods Region will be affected directly and indirectly by a changing climate over the next 100 years. This assessment evaluates the vulnerability of terrestrial ecosystems in the Central Hardwoods Region of Illinois, Indiana, and Missouri to a range of future climates. Information on current forest conditions, observed climate trends,...

  7. Megaloblastic anemia in Japan

    Directory of Open Access Journals (Sweden)

    Taguchi,Hirokuni

    1978-08-01

    Full Text Available Since 1903, 744 cases of megaloblastic anemia have been reported in Japan: 490 cases of pernicious anemia; 95 cases associated with pregnancy; 66 cases after gastrectomy; 22 cases of megaloblastic anemia of infants; 21 cases of folic acid deficiency other than pregnancy and 19 cases of vitamin B12 malabsorption after ileal resection. It is generally agreed among hematologists in Japan that pernicious anemia is relatively rare, as in other Asian countries. The diagnosis of pernicious anemia in Japan is usually made by stained marrow films, radioisotopic assay of serum vitamin B12, Schilling test and good response to vitamin B12 therapy. Serum folate level, intrinsic factor or its antibody, methylmalonic acid excretion, formiminoglutamic acid excretion and deoxyuridine suppression test are performed only at a small number of laboratories. The drugs of choice are hydroxocobalamin, deoxyadenosylcobalamin and methylcobalamin. Cyanocobalamin has nearly disappeared from commercial sources in Japan. Vitamin B12 administration is common in patients with neurological disorders. Megaloblastic anemia due to folic acid deficiency is extremely rare in Japan. Low serum folate levels are frequently observed among patients receiving anticonvulsants or in pregnant women, but in such samples megaloblastic anemia is almost never detected. The folic acid content of hospital diets indicates that satisfactory amounts of folate are taken in Japan. The intake of folic acid from rice is well over the minimum daily requirement of folate. Other factors in folic acid deficiency, such as food taboos, severe alcoholism and malabsorption syndrome are not frequently found in Japanese. The inadequate intake of folate was the critical factor in most reported cases.

  8. Acoustic profiling and surface imaging of the coastal area near the subduction zone: the eastern coastal area of Boso Peninsula, Central Japan.

    Science.gov (United States)

    Furuyama, S.; Sato, T.

    2016-12-01

    The plate motion of the Philippine Sea plate and the Pacific plate influences geology of coastal area in the Pacific side in Japan and sometime causes extensive damage of human activity, such as the Great East Japan Earthquake. It is important to understand the geological structures in a coastal area for disaster prevention. Especially, rapid equipment of geoinformations is highly demanded in the Kanto region where covers capital Tokyo area. Geological Survey of Japan investigated the eastern coastal area in Boso Peninsula, eastern part of the Kanto region, Japan within two years from 2014 to 2015. We obtained seismic sections of ca. 1100 km in total length with a boomer and multi-channel streamer (24 channel with 3.125 m spacing) and report the geological significance of the subsurface structures. The survey area is divided into the northern part of Kujukuri area, the southern part of Kujukuri area, the coastal part of Kujukuri area based on topography and geological structures. In these Kujukuri areas, two strata that show distinct stratification bounded by distinct unconformity distribute and we define them as the Kujukuri A Unit and the Kujukuri B Unit, in ascending order. The lower sequence has some folds and normal faults. These folds that deformed the Kujukuri B Unit extend toward north-northeast in the northern part of Kujukuri area. They contributed to development of wide shelf distributed in this area. In the southern part of Kujukuri area, a lot of faults deformed the Kujukuri B Unit and some of them displaced the Kujukuri A Unit over 10 msec (two way travel). Normal faults developed in the Kujukuri B Unit over 10 msec made grabens and half grabens in the coastal part of Kujukuri area and these grabens and half grabens could make the lowland in the Kujukuri coastal area. The combination of these geological structures identified in the Kujukuri areas could reflect the transition of stress field associated with the subduction of the Philippine Sea plate

  9. Aftershock distribution and heterogeneous structure in and around the source area of the 2014 northern Nagano Prefecture earthquake (Mw 6.2) , central Japan, revealed by dense seismic array observation

    Science.gov (United States)

    Kurashimo, E.; Hirata, N.; Iwasaki, T.; Sakai, S.; Obara, K.; Ishiyama, T.; Sato, H.

    2015-12-01

    A shallow earthquake (Mw 6.2) occurred on November 22 in the northern Nagano Prefecture, central Japan. Aftershock area is located near the Kamishiro fault, which is a part of the Itoigawa-Shizuoka Tectonic Line (ISTL). ISTL is one of the major tectonic boundaries in Japan. Precise aftershock distribution and heterogeneous structure in and around the source region of this earthquake is important to constrain the process of earthquake occurrence. We conducted a high-density seismic array observation in and around source area to investigate aftershock distribution and crustal structure. One hundred sixty-three seismic stations, approximately 1 km apart, were deployed during the period from December 3, 2014 to December 21, 2014. Each seismograph consisted of a 4.5 Hz 3-component seismometer and a digital data recorder (GSX-3). Furthermore, the seismic data at 40 permanent stations were incorporated in our analysis. During the seismic array observation, the Japan Meteorological Agency located 977 earthquakes in a latitude range of 35.5°-37.1°N and a longitude range of 136.7°-139.0°E, from which we selected 500 local events distributed uniformly in the study area. To investigate the aftershock distribution and the crustal structure, the double-difference tomography method [Zhang and Thurber, 2003] was applied to the P- and S-wave arrival time data obtained from 500 local earthquakes. The relocated aftershock distribution shows a concentration on a plane dipping eastward in the vicinity of the mainshock hypocenter. The large slip region (asperity) estimated from InSAR analysis [GSI, 2014] corresponds to the low-activity region of the aftershocks. The depth section of Vp structure shows that the high Vp zone corresponds to the large slip region. These results suggest that structural heterogeneities in and around the fault plane may have controlled the rupture process of the 2014 northern Nagano Prefecture earthquake.

  10. Relationships among temperature, dehydration of the subducting Philippine Sea plate, and the occurrence of a megathrust earthquake, low-frequency earthquakes, and a slow slip event in the Tokai district, central Japan

    Science.gov (United States)

    Suenaga, Nobuaki; Yoshioka, Shoichi; Matsumoto, Takumi

    2016-11-01

    In this study, we performed two-dimensional numerical simulations of temperature distribution associated with subduction of the Philippine Sea (PHS) plate, and estimated the dehydration process of hydrous mid-ocean-ridge basalt (MORB) in the oceanic crust in the Tokai district, central Japan. We discuss the relationship among temperature, dehydration, and a seismogenic zone of an expected megathrust Tokai earthquake, and the occurrence of a slow slip event (SSE) and deep low-frequency earthquakes (LFEs). The depth range of the seismogenic zone for the megathrust earthquake was estimated to be 8-22 km, narrowing toward the east. The most suitable value of the pore pressure ratio on the plate interface was estimated to be 0.97, indicating minimal frictional heating there. The temperatures of the upper surface of the PHS plate, where the Tokai SSE occurred from 2000 to 2005, were estimated to be 350-450 °C. Therefore, the Tokai SSE is considered to have occurred at the transition zone between unstable and stable sliding. In addition, hydrous MORB was transformed from blueschist into greenschist near the region where the Tokai SSE occurred. The temperatures of the upper surface of the PHS plate, where LFEs occur, were estimated to be 450-500 °C. Therefore, LFEs are considered to occur near the down-dip limit of the transition zone. The amount of dehydration from the oceanic crust of the subducting PHS plate near the region where LFEs are distributed in a belt-like form decreases toward the east with deepening of the hypocenters of the LFEs. Thus, the mechanisms of generation of LFEs in the Tokai district might differ from those in southwest and central Japan where LFEs generally occur at depths between 27 and 35 km. In summary, we consider that the occurrence of LFEs is related to both temperature conditions and dehydration process. However, there is an exceptional area in the eastern part of the Tokai district where the occurrence of LFEs is restricted by

  11. State Response to Religious Revivalism in Post-Soviet Central Asia

    Directory of Open Access Journals (Sweden)

    Eren Tatari

    2016-02-01

    Full Text Available After gaining independence from the USSR in 1991, the Islamic heritage of the Central Asian Republics became an alternative ideology to fill the political and social vacuum. Islam gradually started to take its place on the social scene following Gorbachev's Glasnost, as it partially eased the communist oppression towards religious belief and expression. Religious education institutions, mosques, and other religiously affiliated organizations began to emerge. Some of these organizations steadily led their way to political parties with Islamic agendas, and politicization of Islam became a prominent reality. While religious revivalism took sway in Central Asian societies, their governments had an instrumentalist view of religion. Religious expressions were encouraged where they contribute to the goal of nation-building and legitimization of the dominant power coalitions as defined by the power holders. Yet, Central Asian governments proceeded in the opposite direction implementing oppressive policies against extra-governmental religious groups and institutions perceived as a threat. It was anticipated for the Central Asian societies to revive their Islamic heritage that has been suppressed under the Soviet regime and combine religion with nationalist sentiments as a catalyst in the nation-building process and political transition. However, the suppressive state response to this religious revivalism was unpredicted and led to prolonged conflict between state and society. This article seeks to identify the factors that explain the competing courses of the governments' push for secularization through historical institutionalism and cultural and national values approaches.

  12. State Response to Religious Revivalism in Post-Soviet Central Asia

    Directory of Open Access Journals (Sweden)

    Eren Tatari

    2010-10-01

    Full Text Available After gaining independence from the USSR in 1991, the Islamic heritage of the Central Asian Republics became an alternative ideology to fill the political and social vacuum. Islam gradually started to take its place on the social scene following Gorbachev’s Glasnost, as it partially eased the communist oppression towards religious belief and expression. Religious education institutions, mosques, and other religiously affiliated organizations began to emerge. Some of these organizations steadily led their way to political parties with Islamic agendas, and politicization of Islam became a prominent reality. While religious revivalism took sway in Central Asian societies, their governments had an instrumentalist view of religion. Religious expressions were encouraged where they contribute to the goal of nation-building and legitimization of the dominant power coalitions as defined by the power holders. Yet, Central Asian governments proceeded in the opposite direction implementing oppressive policies against extra-governmental religious groups and institutions perceived as a threat. It was anticipated for the Central Asian societies to revive their Islamic heritage that has been suppressed under the Soviet regime and combine religion with nationalist sentiments as a catalyst in the nation-building process and political transition. However, the suppressive state response to this religious revivalism was unpredicted and led to prolonged conflict between state and society. This article seeks to identify the factors that explain the competing courses of the governments’ push for secularization through historical institutionalism and cultural and national values approaches.

  13. Widespread seismicity excitation throughout central Japan following the 2011 M=9.0 Tohoku earthquake and its interpretation by Coulomb stress transfer

    Science.gov (United States)

    Toda, S.; Stein, R.S.; Lin, J.

    2011-01-01

    We report on a broad and unprecedented increase in seismicity rate following the M=9.0 Tohoku mainshock for M ≥ 2 earthquakes over inland Japan, parts of the Japan Sea and Izu islands, at distances of up to 425 km from the locus of high (≥15 m) seismic slip on the megathrust. Such an increase was not seen for the 2004 M=9.1 Sumatra or 2010 M=8.8 Chile earthquakes, but they lacked the seismic networks necessary to detect such small events. Here we explore the possibility that the rate changes are the product of static Coulomb stress transfer to small faults. We use the nodal planes of M ≥ 3.5 earthquakes as proxies for such small active faults, and find that of fifteen regions averaging ~80 by 80 km in size, 11 show a positive association between calculated stress changes and the observed seismicity rate change, 3 show a negative correlation, and for one the changes are too small to assess. This work demonstrates that seismicity can turn on in the nominal stress shadow of a mainshock as long as small geometrically diverse active faults exist there, which is likely quite common.

  14. Life in tidepools: distribution and abundance of two crawling hydromedusae, Staurocladia oahuensis and S. bilateralis, on a rocky intertidal shore in Kominato, central Japan

    Directory of Open Access Journals (Sweden)

    Yayoi M. Hirano

    2000-12-01

    Full Text Available Two crawling medusae, Staurocladia oahuensis (Edmondson, 1930 and S. bilateralis (Edmondson, 1930 were found to be abundant in intertidal rock pools in Kominato from late summer until early winter. The two species were found to rarely share the same individual alga, and sometimes showed exclusive occupancy of pools at higher intertidal levels. The abundance of the two species of medusae fluctuated widely over time with both species showing similar population structures during their period of occurrence. The asexual reproduction of the medusae was considered to be a cause of the distributional pattern and the fluctuation in abundance. An experiment was conducted to evaluate the rate of asexual reproduction under different conditions. At 12°C neither species performed asexual reproduction, while at 17°C and higher temperatures both species reproduced asexually at a high rate. The number of each population was found to nearly double in about a week. The coexistence of the two species of medusae in tidepools is discussed in relation to the habitat characteristics. S. oahuensis and S. bilateralis were not known previously from Japan; this constitutes a new record of both species from Japanese waters. We also found both species in several other warm water locations in Japan.

  15. Japan Report.

    Science.gov (United States)

    1985-05-09

    its warers unless Japan withdraws its objections to the IWC by April i. Abe pointed to the strong American influence on world-wide support of a...squadron of five SH-3 Sea King antisubmarine helicopters which it carries for a squadron of six model H [helicopters] equipped with radar for monitoring ...which appeared in the American newspaper The CHRISTIAN SCIENCE MONITOR on 3 May 1983, introduced a statement by Commander (Holcomb) to the effect that

  16. Japan Report.

    Science.gov (United States)

    2007-11-02

    said Monday. In return, Japan has obtained the right to extend its air service beyond Kuala Lumpur to any further point of its choosing, the...System (MAS) and Northwest Orient Airlines will be dropped, the sources said. JAL and MAS will be allowed to begin new services via Kuala Lumpur and...secondary wood manufacturing and tourism , the leader of a state investment mission said Monday. James M. Root, leader of the 19-member mission, said

  17. Japan Report

    Science.gov (United States)

    2007-11-02

    Japan Socialist Party General Secretary Tsuruo Yamaguchi: "The Deceptiveness of Breaking Through the Defense - Spending Limit of 1 Percent of GNP...Agency Budget Proposal 22 Defense Facilities Administration Agency Budget Proposal 41 Breaking of Defense - Spending Limit Criticized (Tsuruo...such as the high yen and decline in the price of oil. (1) Total Amount Fiscal 1987 defense related expenditures are 3,517.4 billion yen, an

  18. Responses of two tall buildings in Tokyo, Japan, before, during, and after the M9.0 Tohoku earthquake of 11 March 2011

    Science.gov (United States)

    Çelebi, Mehmet; Hisada, Yoshiuaki; Omrani, Roshanak; Ghahari, S. Farid; Taciroglu, Ertugrul

    2016-01-01

    The 11 March 2011 M 9.0 Tohoku earthquake generated significant long duration shaking that propagated hundreds of kilometers from the epicenter and affected urban areas throughout much of Honshu. Recorded responses of tall buildings at several hundred km from the epicenter of the main shock and other events show tall buildings were affected by long-period motions of events at distant sources. This study presents behavioral aspects of 29-story and 30-story neighboring buildings in the Shinjuku area of Tokyo, Japan, as inferred from records retrieved from a sparse array of accelerometers deployed in the superstructures, at ground and 100 m below the ground level over a time interval covering before, during, and after the main shock. Such long-period effects are common in several regions of Japan as well as in the United States and in other seismically active countries. Permanent shifts in fundamental frequencies are observed. Drift ratios indicate possible structural nonlinear behavior occurred during the main shock. The need to consider risks to built environments from distant sources, including those in neighboring countries, is emphasized.

  19. Radar Rainfall Estimates for Modeling Flood Response to Orographic Thunderstorms in the Central Appalachians

    Science.gov (United States)

    Hicks, N. S.; Smith, J. A.

    2001-12-01

    We examine the hydrometeorology and hydrology of extreme flooding from orographic convective systems in the central Appalachian region. Analyses of flood response are based on rainfall and discharge observations for major flood events along the western margin of the central Appalachians (16-17 May 1996, 18-19 July 1996, 30-31 July 1996, 28-29 June 1998, and 7-8 July 2001). A distributed hydrologic model is used to access flood response in Appalachian basins with diverse physiographic properties. High-resolution (1 km, 5 minutes) rainfall fields derived from WSR-88D radars in Charleston, West Virginia and Pittsburgh, Pennsylvania are used for model analyses. Cloud-to-ground lightning and the IFLOWs raingage network provide additional information for hydrometeorological analyses. Flood response is viewed in the context of land surface hydrologic processes and frequency of extreme precipitation events. Orographic convective systems in the Appalachians have produced some of the largest rainfall accumulations in the world for time intervals less than 6 hours and some of the largest unit discharge flood peaks for the U.S. east of the Mississippi River. The 18 July 1942 Smethport, Pennsylvania storm, for example, produced the world record rainfall accumulation of 780 mm in 4.5 hours.

  20. Dexmedetomidine and haemodynamic responses to acute central hypovolaemia in conscious rabbits.

    Science.gov (United States)

    Blake, D W; Ludbrook, J; Van Leeuwen, A F

    2000-10-01

    1. Effects of the alpha2-adrenoceptor agonist dexmedetomidine on vasoconstrictor and heart rate (HR) responses to acute central hypovolaemia were studied in eight chronically instrumented rabbits. We compared intravenous (i.v.) and fourth ventricular (V4) dexmedetomidine (0.1-10 microg/kg) and the reversal of effects by the alpha2-adrenoceptor antagonist idazoxan and the opioid agonist alfentanil. 2. Gradual inflation of an inferior vena cava (IVC) cuff reduced cardiac index (CI) by 8%/min, with progressive vasoconstriction and increased HR. In control rabbits, at approximately 40% baseline CI, there was sudden decompensation with failure of vasoconstriction and a fall in mean arterial pressure (MAP). 3. Dexmedetomidine (i.v. and V4) reduced resting MAP and HR and caused an earlier decompensation during central hypovolaemia. Intravenous dexmedetomidine (3 and 10 microg/kg) also reduced the slope of the initial vasoconstrictor response and the maximum HR. 4. The effects of dexmedetomidine were reversed by the antagonist idazoxan, which prevented the decompensation phase. Intravenous alfentanil was also effective in restoring the vasoconstrictor response and delaying decompensation with hypovolaemia after dexmedetomidine. Combining dexmedetomidine with an opioid, such as alfentanil, may provide the benefit of reduced sympathetic tone without increased risk of cardiovascular collapse.

  1. Vegetation and aquatic communities responses to late Quaternary climate change in central Mexico

    Science.gov (United States)

    Lozano-Garcia, S.; Caballero, M.; Correa-Metrio, A.

    2013-05-01

    A significant amount of information regarding the glacial history of volcanoes, vegetation history and lakes evolution of the Trans Mexican Volcanic Belt (TMVB) is available. The TMVB is a volcanically active highland area, and during its geological history numerous lakes basins have been formed. Climate change has been a significant factor in promoting transformations of the landscape and changes in the vegetation and lake levels during the Quaternary. Paleoclimatic studies carried out in central Mexico have documented variations in temperature and humidity during the late Pleistocene. In order to explore the response of vegetation to late glacial climatic and geological change, multyproxy records of lacustrine sequences from a series of lakes in the western and central sections of the TMVB have been under analysis. Calculated ecological change and its associated rates (RoCs) for six sites that follow an altitudinal and longitudinal gradient of central Mexico offer information on vegetation and dynamics of the lakes in the area. Most of these records show high variability. Dry periods in Lakes Cuitzeo and Zacapu (the most western and lower locations) show high RoC and seem to coincide with Heinrich events (H4 and H5). Contrastingly, RoC in Chalco and Texcoco records (the eastern and higher locations) seem more variable. The observed patterns are most likely the result of the confluence of climate, geologic events, and human occupation, all of them interacting at different time scales and posing difficulties when interpreting fossil sequences from the area.

  2. Influence of Vegetation Cover on Rain Pulse Responses in Semi-Arid Savannas in Central Texas

    Science.gov (United States)

    Litvak, M.; Heilman, J.; McInnes, K.; Thijs, A.; Kjelgaard, J.

    2007-12-01

    Savannas in central Texas are dominated by live oak (Quercus virginiana) and Ashe juniper (Juniperus asheii) underlain by perennial, C3/C4 grasslands, and are increasingly becoming juniper and mesquite dominated due to overgrazing and suppression of wildfires. Since 2004, we have been investigating how carbon, water and energy exchange in these rain-limited savannas respond to rainfall variability and this observed vegetation change. In semi-arid regions, rainfall pulses provide inputs of soil moisture and trigger biotic activity in the form of plant gas exchange and microbial metabolism as well as water dependent physical processes in the soil. Each of these components has a different characteristic response curve to soil moisture and integrates soil water content over a different range of depths. Here we focus on examining how the observed increase of woody species in central Texas savannas alters the response of net ecosystem exchange and its components, ecosystem respiration and gross ecosystem exchange, to rain pulses. Using data we have collected over the last three years from three Ameriflux tower sites at Freeman Ranch near San Marcos, TX (C3/C4 grassland, juniper/mesquite savanna with 50 percent woody cover, and oak/juniper woodland), we quantify the responses of both ecosystem respiration and daily carbon uptake to rainfall pulses throughout the year. Specifically, we look at the enhancement and persistence of ecosystem respiration and carbon uptake responses following a pulse, and isolate the main controlling factors on the observed response: seasonality, antecedent soil moisture and temperature, or previous pulses. In all three land covers, the general response to precipitation pulses is a respiration pulse followed by an increase in total carbon uptake. Differences in pulse responses observed at the savanna site compared to the grassland and woodland sites can be explained, in part, by the observed differences in rooting structure and photosynthetic

  3. Can we remove iodine-131 from tap water in Japan by boiling? - Experimental testing in response to the Fukushima Daiichi Nuclear Power Plant accident.

    Science.gov (United States)

    Tagami, K; Uchida, S

    2011-08-01

    Iodine-131 concentrations in tap water higher than 100 BqL(-1) were reported by several local governments in Japan following the Fukushima Daiichi Nuclear Power Plant accident. Some individuals in the emergency-response community recommended the boiling of tap water to remove iodine-131. However, the tap water boiling tests in this study showed no iodine-131 loss from the tap water with either short-term boiling (1-10 min) or prolonged boiling (up to 30 min) resulting in up to 3-fold volume reductions. In this situation, boiling was shown to be not effective in removing iodine-131 from tap water; indeed even higher concentrations may result from the liquid-volume reduction accompanying this process.

  4. Asymmetry in the response of central Eurasian winter temperature to AMO

    Science.gov (United States)

    Hao, Xin; He, Shengping; Wang, Huijun

    2016-10-01

    The asymmetry in the teleconnection of the central Eurasian winter surface air temperature (SAT) with the Atlantic multidecadal oscillation (AMO) is discussed using observations and model simulations. Observations indicate that the winter SAT over central Eurasia (30°-70°E, 30°-50°N) shows significant positive anomalies during the warm AMO period but weak and insignificant anomalies in the cold AMO period. In general, the warm winters in central Eurasia are associated with large-scale negative sea level pressure anomalies in Europe, anomalous southwesterly winds at 850 hPa over Europe, the "+ - +" geopotential height anomalies at 500 hPa in the south of Greenland, northern Europe, western Asia, and the slant north-south "+ -" pattern jet stream anomalies at 200 hPa in the north and south of the Caspian Sea. Reverse patterns occur during cold winters. These statistically significant features are observed in the warm phase of AMO. Reversed circulation anomalies are observed during the cold phase of AMO; however, these anomalies are weak and not statistically significant. Furthermore, the asymmetry in the atmospheric response to AMO is well supported by simulations with a suite of GFDL atmospheric model idealized experiments and four CMIP5 models historical experiments. Both observations and simulations indicate that Rossby waves propagating from the North Atlantic eastward to Eurasia emerge in the warm AMO and disappear in the cold AMO. Thus, the different propagations of Rossby waves, induced by the different surface thermal conditions of the warm and cold AMO, are the potential connection between the North Atlantic Ocean and central Eurasian climate, and may explain the asymmetry.

  5. Thermal Responses of Growth and Toxin Production in Four Prorocentrum Species from the Central Red Sea

    KAUST Repository

    Aynousah, Arwa

    2017-06-01

    Harmful algae studies, in particular toxic dinoflagellates, and their response to global warming in the Red Sea are still limited. This study was aimed to be the first to characterize the identity, thermal responses and toxin production of four Prorocentrum strains isolated from the Central Red Sea, Saudi Arabia. Morphological and molecular phylogenetic analysis identified the strains as P. elegans, P. rhathymum and P. emarginatum. However, the identity of strain P. sp.6 is currently unresolved, albeit sharing close affinity with P. leve. Growth experiments showed that all species could grow at 24-32°C, but only P. sp.6 survived the 34°C treatment. The optimum temperatures (Topt) estimated from the Gaussian model corresponded to 27.17, 29.33, 26.87, and 27.64°C for P. sp.6, P. elegans, P. rhathymum and P. emarginatum, respectively. However, some discrepancy with the Topt derived from the growth performance were observed for P. elegans and P. emarginatum, as thermal responses differed from the typical Gaussian fit. The Prorocentrum species examined showed a sharp decrease after the optimum temperature resulting in very high activation energies for the fall slope, especially for P. elegans and P. emarginatum. The minimum critical temperature limit for growth was not detected within the range of temperatures examined. Subsequently, high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) analysis revealed all species as non okadaic acid (OA, common toxin of the Prorocentrum genus) producers at any temperature treatment. However, other forms of toxin (i.e. fast acting toxins) not examined here could be produced. Therefore, further investigations are required. The results of this study provided significant contribution to our knowledge regarding the presence, thermal response and toxin production of four Prorocentrum species from the Central Red Sea, Saudi Arabia.

  6. Factors affecting the United Nations' response to natural disasters: what determines the allocation of the Central Emergency Response Fund?

    Science.gov (United States)

    Robinson, Tyler D; Oliveira, Thiago M; Kayden, Stephanie

    2017-01-30

    Natural disasters can overwhelm the domestic response of a country, leaving it dependent on external humanitarian relief. The Central Emergency Response Fund (CERF) of the United Nations centralises humanitarian funding and thus allows for a rapid response. This study combined data to analyse the factors that affected the allocation of CERF funding to countries that suffered a natural disaster between 2007 and 2013. It generated descriptive statistics and information on relative risks, and performed regressions of CERF funding across countries. There were 4,346 disasters in total in 188 countries between 2007 and 2013. CERF provided USD 2.98 billion to 87 countries, comprising 3.3 per cent of their total humanitarian funding. CERF more frequently supplied aid to countries in North Africa and the Middle East, and to those that had suffered geophysical disasters. Appropriately, it funds vulnerable countries experiencing severe natural disasters, yet its funding may be affected by variables beyond severity and vulnerability. Further investigation is warranted, therefore.

  7. Synoptic climatological study on the decrease in heavy snowfall days in Hokuriku District of Central Japan after the latter half of 1980s

    Science.gov (United States)

    Kato, Kuranoshin; Kan, Yuusuke

    2010-05-01

    Many reports point out that the total snowfall amount in winter in the Japan Sea side of the Japan Islands, such as Hokuriku District, decreased considerably after the latter half of 1980s, in coincidence with the Global Warming together with the interdecadal variation. As for around December, this seems to be partly because more precipitation in the winter monsoon situation is brought as rainfall (not as snowfall), due to the warmer temperature than before. On the other hand, contribution of the daily heavy snowfall events there would be also important for mid-winter when the air temperature is the lowest in a year. Thus the present study examined the contribution of the heavy snowfall events to the difference of the total snowfall amount before and after the middle of 1980s, based on the daily data at several operational surface observation stations of JMA in the Hokuriku District for 1971 - 2001. Then the related daily atmospheric fields were analyzed climatologically with use of the NCEP/NCAR re-analysis data with every 2.5 degrees latitude/longitude interval. In the former half of the analysis period, the larger total snowfall amount in January in the Hokuriku District, such as at Takada, was greatly contributed to by the heavy snowfall events with more than 30 cm/day (referred to as "heavy snowfall day", hereafter). The decrease in the total amount in the latter half of that period was due to that in the contribution of "heavy snowfall days". Furthermore, the "heavy snowfall days" tended to appear in the persistent snowfall episodes (including also the days with 10 cm/day), before around 1986. In short, the decrease in the total snowfall in the latter half period there seems to be reflected by the weakening of persistency of heavy snowfall episodes. As shown by Akiyama (1981a and b) in detail, there are several different synoptic situations in the winter monsoon situation for bringing heavy snowfall there (the "mountain snow type" and the "plateau snow type

  8. Response of a tall building far from the epicenter of the 11 March 2011 M 9.0 Great East Japan earthquake and aftershocks

    Science.gov (United States)

    Celebi, Mehmet; Okawa, Izuru; Kashima, Toshidate; Koyama, Shin; Iiba, Masanori

    2012-01-01

    The 11 March 2011 M 9.0 Great East Japan earthquake generated significant long-duration shaking that propagated hundreds of kilometers from the epicenter and affected urban areas throughout much of Honshu. Recorded responses of a tall building at 770 km from the epicenter of the mainshock and other related or unrelated events show how structures sensitive to long-period motions can be affected by distant sources. Even when the largest peak input motions to the building is about 3% g, the strong-shaking duration was about 140 s. The 300- to 1000-s prolonged responses of the building are primarily due to a combination of site resonance (e.g. structural fundamental frequency ~0.15 Hz and site frequency ~0.13–0.17 Hz) and low damping (~1–2%) of the structure. Response modification technologies can improve the response of the building during future earthquakes. The need-to-consider risks to such built environments from distant sources are emphasized.

  9. Wind Energy Japan

    Energy Technology Data Exchange (ETDEWEB)

    Komatsubara, Kazuyo [Embassy of the Kingdom of the Netherlands, Tokyo (Japan)

    2012-06-15

    An overview is given of wind energy in Japan: Background; Wind Energy in Japan; Japanese Wind Energy Industry; Government Supports; Useful Links; Major Japanese Companies; Profiles of Major Japanese Companies; Major Wind Energy Projects in Japan.

  10. Subtyping Schizophrenia by Treatment Response: Antipsychotic Development and the Central Role of Positive Symptoms.

    Science.gov (United States)

    Lee, Jimmy; Takeuchi, Hiroyoshi; Fervaha, Gagan; Sin, Gwen Li; Foussias, George; Agid, Ofer; Farooq, Saeed; Remington, Gary

    2015-11-01

    We have recently proposed a model for subtyping schizophrenia based on antipsychotic (AP) treatment response. Evidence suggests that APs, both old and new, are comparable in terms of efficacy; however, one AP, clozapine, is uniquely effective in one subgroup of patients (that is, those with treatment-resistant schizophrenia [TRS]). This permits us to subdivide schizophrenia into 3 specific groups: AP responsive, clozapine responsive, and clozapine resistant. Here, we integrate this model with current criteria related to TRS and ultraresistant schizophrenia, the latter referred to in our model as clozapine resistant. We suggest several modifications to existing criteria, in line with current evidence and practice patterns, particularly emphasizing the need to focus on positive symptoms. While APs can favourably impact numerous dimensions related to schizophrenia, it is their effect on positive symptoms that distinguishes them from other psychotropics. Further, it is positive symptoms that are central to AP and clozapine resistance, and it is these people that place the greatest demands on acute and long-term inpatient resources. In moving AP development forward, we advocate specifically focusing on positive symptoms and capitalizing on the evidence we have of 3 subtypes of psychosis (that is, positive symptoms) based on treatment response, implicating 3 distinguishable forms of underlying pathophysiology. Conversely, pooling these groups risks obfuscating potentially identifiable differences. Such a position does not challenge the importance of dopamine D2 receptor blockade, but rather highlights the need to better isolate those other subgroups that require something more or entirely different.

  11. Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons.

    Science.gov (United States)

    Casey, Kenneth L; Geisser, Michael; Lorenz, Jürgen; Morrow, Thomas J; Paulson, Pamela; Minoshima, Satoshi

    2012-02-01

    Patients with central pain (CP) typically have chronic pain within an area of reduced pain and temperature sensation, suggesting an impairment of endogenous pain modulation mechanisms. We tested the hypothesis that some brain structures normally activated by cutaneous heat stimulation would be hyperresponsive among patients with CP but not among patients with a central nervous system lesion causing a loss of heat or nociceptive sensation with no pain (NP). We used H(2)(15)O positron emission tomography to measure, in 15 healthy control participants, 10 NP patients, and 10 CP patients, increases in regional cerebral blood flow among volumes of interest (VOI) from the resting (no stimulus) condition during bilateral contact heat stimulation at heat detection, heat pain threshold, and heat pain tolerance levels. Both patient groups had a reduced perception of heat intensity and unpleasantness on the clinically affected side and a bilateral impairment of heat detection. Compared with the HC group, both NP and CP patients had more hyperactive and hypoactive VOI in the resting state and more hyperresponsive and hyporesponsive VOI during heat stimulation. Compared with NP patients, CP patients had more hyperresponsive VOI in the intralaminar thalamus and sensory-motor cortex during heat stimulation. Our results show that focal CNS lesions produce bilateral sensory deficits and widespread changes in the nociceptive excitability of the brain. The increased nociceptive excitability within the intralaminar thalamus and sensory-motor cortex of our sample of CP patients suggests an underlying pathophysiology for the pain in some central pain syndromes.

  12. Effects of aging on thermoregulatory responses and hormonal changes in humans during the four seasons in Japan

    Science.gov (United States)

    Sato, Maki; Kanikowska, Dominika; Sugenoya, Junichi; Inukai, Yoko; Shimizu, Yuuki; Nishimura, Naoki; Iwase, Satoshi

    2011-03-01

    Physiological functions are impaired in various organs in aged people, as manifest by, e.g., renal and cardiac dysfunction and muscle atrophy. The elderly are also at increased risk of both hypothermia and hyperthermia in extreme temperatures. The majority of those over 65 years old have elevated serum osmolality. Our hypothesis is that the elderly have suppressed osmolality control in different seasons compared to the young. Eight healthy young men and six healthy older men participated in this study. The experiments were performed during spring, summer, autumn and winter in Japan, with average atmospheric temperatures of 15-20°C in spring, 25-30°C in summer, 15-23°C in autumn and 5-10°C in winter. Each subject immersed his lower legs in warm water at 40°C for 30 min. Core (tympanic) temperature and sweat rate at chest were recorded continuously. Blood was taken pre-immersion to measure the concentrations of antidiuretic hormone, serum osmolality, plasma renin activity, angiotensin II, aldosterone, leptin, thyroid stimulating hormone, fT3 and fT4. The results suggested that the elderly have suppressed osmolality control compared to the young; osmolality was especially elevated in winter compared to the summer in elderly subjects. Therefore, particularly in the elderly, balancing fluid by drinking water should be encouraged to maintain euhydration status in winter.

  13. Neuropeptides in the posterodorsal medial amygdala modulate central cardiovascular reflex responses in awake male rats

    Energy Technology Data Exchange (ETDEWEB)

    Quagliotto, E. [Departamento de Ciências Básicas da Saúde/Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS (Brazil); Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil); Casali, K.R. [Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, SP (Brazil); Dal Lago, P. [Departamento de Fisioterapia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS (Brazil); Rasia-Filho, A.A. [Departamento de Ciências Básicas da Saúde/Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS (Brazil); Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil)

    2014-11-21

    The rat posterodorsal medial amygdala (MePD) links emotionally charged sensory stimuli to social behavior, and is part of the supramedullary control of the cardiovascular system. We studied the effects of microinjections of neuroactive peptides markedly found in the MePD, namely oxytocin (OT, 10 ng and 25 pg; n=6/group), somatostatin (SST, 1 and 0.05 μM; n=8 and 5, respectively), and angiotensin II (Ang II, 50 pmol and 50 fmol; n=7/group), on basal cardiovascular activity and on baroreflex- and chemoreflex-mediated responses in awake adult male rats. Power spectral and symbolic analyses were applied to pulse interval and systolic arterial pressure series to identify centrally mediated sympathetic/parasympathetic components in the heart rate variability (HRV) and arterial pressure variability (APV). No microinjected substance affected basal parameters. On the other hand, compared with the control data (saline, 0.3 µL; n=7), OT (10 ng) decreased mean AP (MAP{sub 50}) after baroreflex stimulation and increased both the mean AP response after chemoreflex activation and the high-frequency component of the HRV. OT (25 pg) increased overall HRV but did not affect any parameter of the symbolic analysis. SST (1 μM) decreased MAP{sub 50}, and SST (0.05 μM) enhanced the sympathovagal cardiac index. Both doses of SST increased HRV and its low-frequency component. Ang II (50 pmol) increased HRV and reduced the two unlike variations pattern of the symbolic analysis (P<0.05 in all cases). These results demonstrate neuropeptidergic actions in the MePD for both the increase in the range of the cardiovascular reflex responses and the involvement of the central sympathetic and parasympathetic systems on HRV and APV.

  14. Forest response to increased disturbance in the Central Amazon and comparison to Western Amazonian forests

    Science.gov (United States)

    Holm, J. A.; Chambers, J. Q.; Collins, W.; Higuchi, N.

    2014-12-01

    Uncertainties surrounding vegetation response to increased disturbance rates associated with climate change remains a major global change issue for Amazon forests. Additionally, turnover rates in the Western Amazon are doubled compared to the Central Amazon, and notable gradients currently exist in specific wood density and aboveground biomass (AGB). This study investigates the extent to which the variation in disturbance regimes contributes to these regional gradients. To address these issues, we evaluated disturbance-recovery processes under scenarios of increased disturbance rates in a Central Amazon forest using first ZELIG-TROP, a dynamic vegetation gap model which we calibrated using long-term inventory data, and second using the Community Land Model (CLM), a global land surface model. Upon doubling the mortality rate in the Central Amazon to mirror the disturbance regime in the Western Amazon of ~2% mortality, the two regions continued to differ in multiple forest processes. With the inclusion of elevated natural disturbances, at steady-state, AGB significantly decreased by 41.9% with no significant difference between modeled AGB and empirical AGB from the western Amazon datasets (104 vs. 107 Mg C ha-1). However, different processes were responsible for the reductions in AGB between the models and empirical dataset. The empirical dataset suggests that a decrease in wood density drives the reduction in AGB. While decreased stand basal area was the driver of AGB loss in ZELIG-TROP, and decreased leaf area index (LAI) was the driver in CLM, two forest attributes that do not significantly vary across the Amazon Basin. Further comparisons found that stem density, specific wood density, and growth rates differed between the two Amazonian regions. This suggests that: 1) the variability between regions cannot be entirely explained by the variability in disturbance regime, but rather potentially sensitive to intrinsic environmental factors; or 2) the models are not

  15. Paleomagnetic direction and paleointensity variations during the Matuyama-Brunhes polarity transition from a marine succession in the Chiba composite section of the Boso Peninsula, central Japan

    Science.gov (United States)

    Okada, Makoto; Suganuma, Yusuke; Haneda, Yuki; Kazaoka, Osamu

    2017-03-01

    The youngest geomagnetic polarity reversal, the Matuyama-Brunhes (M-B) boundary, provides an important plane of data for sediments, ice cores, and lavas. The geomagnetic field intensity and directional changes that occurred during the reversal also provide important information for understanding the dynamics of the Earth's outer core, which generates the magnetic field. However, the reversal process is relatively rapid in terms of the geological timescale; therefore, adequate temporal resolution of the geomagnetic field record is essential for addressing these topics. Here, we report a new high-resolution paleomagnetic record from a continuous marine succession in the Chiba composite section of the Kokumoto Formation of the Kazusa Group, Japan, that reveals detailed behaviors of the virtual geomagnetic poles (VGPs) and relative paleointensity changes during the M-B polarity transition. The resultant relative paleointensity and VGP records show a significant paleointensity minimum near the M-B boundary, which is accompanied by a clear "polarity switch." A newly obtained high-resolution oxygen isotope chronology for the Chiba composite section indicates that the M-B boundary is located in the middle of marine isotope stage (MIS) 19 and yields an age of 771.7 ka for the boundary. This age is consistent with those based on the latest astronomically tuned marine and ice core records and with the recalculated age of 770.9 ± 7.3 ka deduced from the U-Pb zircon age of the Byk-E tephra. To the best of our knowledge, our new paleomagnetic data represent one of the most detailed records on this geomagnetic field reversal that has thus far been obtained from marine sediments and will therefore be key for understanding the dynamics of the geomagnetic dynamo and for calibrating the geological timescale.[Figure not available: see fulltext.

  16. A study of the Taisho lahar generated by the 1926 eruption of Tokachidake Volcano, central Hokkaido, Japan, and implications for the generation of cohesive lahars

    Science.gov (United States)

    Uesawa, Shimpei

    2014-01-01

    Understanding the generation mechanisms of lahars is important for improving volcanic hazard assessments. The Taisho lahar (TL) was generated during the 1926 eruption of Tokachidake Volcano, Japan, and was considered a typical snowmelt lahar caused by the runout of hot debris onto a snow-covered slope. A similar mechanism produced a huge mud flow during the 1985 eruption of Nevado del Ruiz, Colombia. However, the origin of water in such lahars remains a controversial topic because the calculated water mass is based on the assumption that all of the snow on the runout area of the TL was melted, although this is much less than the estimated water volume in the TL estimated by previous studies. I have re-examined proximal deposits of the TL and their paleomagnetic characteristics in order to better understand the eruption sequence and formation of the TL. The TL produced two debris avalanche deposits and a surge-like deposit that had relatively high emplacement temperature (~ 350 °C). The deposits are composed of hydrothermally altered andesitic gravel, sand and mud. The high clay content (3-5 wt.% clay in the pyroclastic cone (hypocenter). The presence of the surge deposit indicates that the TL was not caused by simple collapse of a cinder cone but by a phreatic explosion that resulted in sector collapse. This suggests that the hydrothermal system was related to the 1926 eruption. The present-day volcano has a large hydrothermal system (1 × 106 m3 water) beneath the active crater. This study indicates that hydrothermal system explosions can trigger cohesive lahars that contain both snow melt and hydrothermal pore water, and this indicates the need to monitor hydrothermal systems.

  17. Central nervous system effects of the second-generation antihistamines marketed in Japan--review of inter-drug differences using the proportional impairment ratio (PIR-.

    Directory of Open Access Journals (Sweden)

    Tatsuya Isomura

    Full Text Available BACKGROUND: Second-generation antihistamines (AHs have, in general, fewer sedative effects than the first-generation. However, important inter-drug differences remain in the degree of cognitive and/or psychomotor impairment. The extent to which a particular compound causes disruption can be conveniently compared, to all other AHs, using the Proportional Impairment Ratio (PIR. Although the PIR can differentiate the relative impairment caused by individual drugs, there is no indication of the reliability of the ratios obtained. OBJECTIVE: To calculate the PIRs -together with 95% confidence intervals (CIs, as an index of reliability- and compare AHs currently, or soon to be, available in Japan, with respect to their intrinsic capacity to cause impairment. METHODS: Results from studies of cetirizine, desloratadine, ebastine, fexofenadine, levocetirizine, loratadine, mequitazine, and olopatadine were included in the PIR calculations. All data utilised came from crossover studies in healthy volunteers which were randomised and placebo and positive-internal controlled. Existing databases from studies reporting the sedative effects of AHs on objective (speed, accuracy, memory and subjective (feeling psychometrics were augmented, via results from suitable studies published after the previous reviews. The null value for a PIR was one. RESULTS: A total of 45 studies were finally included for this review. Of the AHs assessed, fexofenadine, ebastine, and levocetirizine showed a PIR for objective tests of 0. However, only fexofenadine (PIR = 0.49 had an upper limit of the 95% CI of less than 1. Fexofenadine, levocetirizine, desloratadine, olopatadine, loratadine, and mequitazine all had a PIR for subjective ratings of 0, but the upper limits of the 95% CIs were all in excess of 1, although fexofenadine (PIR = 2.57 was the lowest. CONCLUSIONS: The results show that there are differences between second-generation AHs in the extent of sedation produced

  18. Reduced compensatory responses to maintain central blood volume during hypovolemic stress in women with vasovagal syncope.

    Science.gov (United States)

    Skoog, Johan; Zachrisson, Helene; Länne, Toste; Lindenberger, Marcus

    2017-01-01

    Although vasovagal syncope (VVS) is a common clinical condition, the underlying pathophysiology is not fully understood. A decrease in cardiac output has recently been suggested as a factor in orthostatic VVS. The aim was to investigate compensatory mechanisms to maintain central blood volume and venous return during hypovolemic stress in women with VVS. Fourteen VVS women (25.7 ± 5.0 yr) and 15 matched controls (22.8 ± 3.2 yr) were investigated. Single-step and graded lower body negative pressure (LBNP) to presyncope were used to create hypovolemic stress. Peripheral mobilization of venous blood from the arm (capacitance response and net capillary fluid absorption) and lower limb blood pooling (calf capacitance response) were evaluated using a volumetric technique. Cardiovascular responses and plasma norepinephrine (P-NE) were measured. Resting P-NE was elevated in VVS women (P < 0.01). Despite a similar hypovolemic stimulus, the increase in P-NE was blunted (P < 0.01) and the maximal percent increase in total peripheral resistance was reduced (P < 0.05) during graded LBNP in VVS women. The arm capacitance response was slower (P < 0.05) and reduced in VVS women at higher levels of LBNP (P < 0.05). Capillary fluid absorption from extra- to intravascular space was reduced by ∼40% in VVS women (P < 0.05). Accordingly, the reduction in cardiac output was more pronounced (P < 0.05). In conclusion, in VVS women, mobilization of peripheral venous blood and net fluid absorption from tissue to blood during hypovolemic stress were decreased partly as a result of an attenuated vasoconstrictor response. This may seriously impede maintenance of cardiac output during hypovolemic stress and could contribute to the pathogenesis of VVS.

  19. Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster.

    Science.gov (United States)

    Alò, Raffaella; Avolio, Ennio; Mele, Maria; Di Vito, Anna; Canonaco, Marcello

    2015-04-15

    Interaction of the orexinergic (ORXergic) neuronal system with the excitatory (glutamate, l-Glu) or the inhibitory (GABA) neurosignaling complexes evokes major homeostatic physiological events. In this study, effects of the two ORXergic neuropeptides (ORX-A/B) on their receptor (ORX-2R) expression changes were correlated to feeding and grooming actions of the hibernating hamster (Mesocricetus auratus). Infusion of the central amygdala nucleus (CeA) with ORX-A caused hamsters to consume notable quantities of food, while ORX-B accounted for a moderate increase. Interestingly the latter neuropeptide was responsible for greater frequencies of grooming with respect to both controls and the hamsters treated with ORX-A. These distinct behavioral changes turned out to be even greater in the presence of l-Glu agonist (NMDA) while the α1 GABAA receptor agonist (zolpidem, Zol) greatly reduced ORX-A-dependent feeding bouts. Moreover, ORX-A+NMDA mainly promoted greater ORX-2R expression levels with respect to ORX-A-treated hamsters while ORX-B+Zol was instead largely responsible for a down-regulatory trend. Overall, these features point to CeA ORX-2R sites as key sensory limbic elements capable of regulating eating and grooming responses, which may provide useful insights regarding the type of molecular mechanism(s) operating during feeding bouts.

  20. Central stimulation of hormone release and the proliferative response of lymphocytes in humans.

    Science.gov (United States)

    Juránková, E; Jezová, D; Vigas, M

    1995-01-01

    The central nervous system (CNS) may communicate with the immune system by direct innervation of lymphoid organs and/or by neurotransmitters and changes in neuroendocrine functioning and hormone release. The consequences of selective transient changes in circulating hormones on immune functioning in humans have not yet been studied. To address this problem, the authors evaluated the lymphoproliferative responses to optimal and suboptimal concentrations of phytohemagglutinin (PHA) and pokeweek mitogen (PWM) under selective enhancement of circulating growth hormone, prolactin, or norepinephrine. The authors failed to demonstrate any effect of elevated growth hormone levels after clonidine challenge on the lymphoproliferative response to mitogens. Similarly, the results did not show any effect of elevated prolactin concentrations induced by domperidone administration on the immune test. Exposure of volunteers to cold resulted in elevation of plasma norepinephrine levels without changes in growth hormone, epinephrine, or cortisol secretion. Cold exposure induced elevation of plasma norepinephrine and reduction of the lymphoproliferative response to the suboptimal dosage of PHA. The reduction was significant 180 and 240 min after exposure. These results are indicative of a relationship between norepinephrine and immunity.

  1. Peripheral, central and behavioral responses to the cuticular pheromone bouquet in Drosophila melanogaster males.

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Inoshita

    Full Text Available Pheromonal communication is crucial with regard to mate choice in many animals including insects. Drosophila melanogaster flies produce a pheromonal bouquet with many cuticular hydrocarbons some of which diverge between the sexes and differently affect male courtship behavior. Cuticular pheromones have a relatively high weight and are thought to be -- mostly but not only -- detected by gustatory contact. However, the response of the peripheral and central gustatory systems to these substances remains poorly explored. We measured the effect induced by pheromonal cuticular mixtures on (i the electrophysiological response of peripheral gustatory receptor neurons, (ii the calcium variation in brain centers receiving these gustatory inputs and (iii the behavioral reaction induced in control males and in mutant desat1 males, which show abnormal pheromone production and perception. While male and female pheromones induced inhibitory-like effects on taste receptor neurons, the contact of male pheromones on male fore-tarsi elicits a long-lasting response of higher intensity in the dedicated gustatory brain center. We found that the behavior of control males was more strongly inhibited by male pheromones than by female pheromones, but this difference disappeared in anosmic males. Mutant desat1 males showed an increased sensitivity of their peripheral gustatory neurons to contact pheromones and a behavioral incapacity to discriminate sex pheromones. Together our data indicate that cuticular hydrocarbons induce long-lasting inhibitory effects on the relevant taste pathway which may interact with the olfactory pathway to modulate pheromonal perception.

  2. Peripheral, Central and Behavioral Responses to the Cuticular Pheromone Bouquet in Drosophila melanogaster Males

    Science.gov (United States)

    Inoshita, Tsuyoshi; Martin, Jean-René; Marion-Poll, Frédéric; Ferveur, Jean-François

    2011-01-01

    Pheromonal communication is crucial with regard to mate choice in many animals including insects. Drosophila melanogaster flies produce a pheromonal bouquet with many cuticular hydrocarbons some of which diverge between the sexes and differently affect male courtship behavior. Cuticular pheromones have a relatively high weight and are thought to be — mostly but not only — detected by gustatory contact. However, the response of the peripheral and central gustatory systems to these substances remains poorly explored. We measured the effect induced by pheromonal cuticular mixtures on (i) the electrophysiological response of peripheral gustatory receptor neurons, (ii) the calcium variation in brain centers receiving these gustatory inputs and (iii) the behavioral reaction induced in control males and in mutant desat1 males, which show abnormal pheromone production and perception. While male and female pheromones induced inhibitory-like effects on taste receptor neurons, the contact of male pheromones on male fore-tarsi elicits a long-lasting response of higher intensity in the dedicated gustatory brain center. We found that the behavior of control males was more strongly inhibited by male pheromones than by female pheromones, but this difference disappeared in anosmic males. Mutant desat1 males showed an increased sensitivity of their peripheral gustatory neurons to contact pheromones and a behavioral incapacity to discriminate sex pheromones. Together our data indicate that cuticular hydrocarbons induce long-lasting inhibitory effects on the relevant taste pathway which may interact with the olfactory pathway to modulate pheromonal perception. PMID:21625481

  3. Effects of caffeine on the electrophysiological, cognitive and motor responses of the central nervous system

    Directory of Open Access Journals (Sweden)

    Deslandes A.C.

    2005-01-01

    Full Text Available Caffeine is the most consumed psychoactive substance in the world. The effects of caffeine have been studied using cognitive and motor measures, quantitative electroencephalography (qEEG and event-related potentials. However, these methods are not usually employed in combination, a fact that impairs the interpretation of the results. The objective of the present study was to analyze changes in electrophysiological, cognitive and motor variables with the ingestion of caffeine, and to relate central to peripheral responses. For this purpose we recorded event-related potentials and eyes-closed, resting EEG, applied the Stroop test, and measured reaction time. Fifteen volunteers took caffeine (400 mg or placebo in a randomized, crossover, double-blind design. A significant reduction of alpha absolute power over the entire scalp and of P300 latency at the Fz electrode were observed after caffeine ingestion. These results are consistent with a stimulatory effect of caffeine, although there was no change in the attention (Stroop test or in reaction time. The qEEG seems to be the most sensitive index of the changes produced by caffeine in the central nervous system since it proved to be capable of detecting changes that were not evident in the tests of cognitive or motor performance.

  4. Climate-induced larch growth response within the central Siberian permafrost zone

    Science.gov (United States)

    Kharuk, Viacheslav I.; Ranson, Kenneth J.; Im, Sergei T.; Petrov, Il'ya A.

    2015-12-01

    Aim: estimation of larch (Larix gmelinii) growth response to current climate changes. Location: permafrost area within the northern part of Central Siberia (˜65.8°N, 98.5°E). Method: analysis of dendrochronological data, climate variables, drought index SPEI, GPP (gross primary production) and EVI vegetation index (both Aqua/MODIS satellite derived), and soil water content anomalies (GRACE satellite measurements of equivalent water thickness anomalies, EWTA). Results: larch tree ring width (TRW) correlated with previous year August precipitation (r = 0.63), snow accumulation (r = 0.61), soil water anomalies (r = 0.79), early summer temperatures and water vapor pressure (r = 0.73 and r = 0.69, respectively), May and June drought index (r = 0.68-0.82). There are significant positive trends of TRW since late 1980 s and GPP since the year 2000. Mean TRW increased by about 50%, which is similar to post-Little Ice Age warming. TRW correlated with GPP and EVI of larch stands (r = 0.68-0.69). Main conclusions: within the permafrost zone of central Siberia larch TRW growth is limited by early summer temperatures, available water from snowmelt, water accumulated within soil in the previous year, and permafrost thaw water. Water stress is one of the limiting factors of larch growth. Larch TRW growth and GPP increased during recent decades.

  5. In the presence of danger:the extracellular matrix defensive response to central nervous system injury

    Institute of Scientific and Technical Information of China (English)

    Lyn B. Jakeman; Kent E. Williams; Bryan Brautigam

    2014-01-01

    Glial cells in the central nervous system (CNS) contribute to formation of the extracellular matrix, which provides adhesive sites, signaling molecules, and a diffusion barrier to enhance efifcient neurotransmission and axon potential propagation. In the normal adult CNS, the extracellular matrix (ECM) is relatively stable except in selected regions characterized by dynamic remodel-ing. However, after trauma such as a spinal cord injury or cortical contusion, the lesion epicenter becomes a focus of acute neuroinlfammation. The activation of the surrounding glial cells leads to a dramatic change in the composition of the ECM at the edges of the lesion, creating a perile-sion environment dominated by growth inhibitory molecules and restoration of the peripheral/central nervous system border. An advantage of this response is to limit the invasion of damaging cells and diffusion of toxic molecules into the spared tissue regions, but this occurs at the cost of inhibiting migration of endogenous repair cells and preventing axonal regrowth. The following review was prepared by reading and discussing over 200 research articles in the ifeld published in PubMed and selecting those with signiifcant impact and/or controversial points. This article highlights structural and functional features of the normal adult CNS ECM and then focuses on the reactions of glial cells and changes in the perilesion border that occur following spinal cord or contusive brain injury. Current research strategies directed at modifying the inhibitory perile-sion microenvironment without eliminating the protective functions of glial cell activation are discussed.

  6. Climate-Induced Larch Growth Response Within the Central Siberian Permafrost Zone

    Science.gov (United States)

    Kharuk, Viacheslav I.; Ranson, Kenneth J.; Im, Sergei T.; Petrov, Il'ya A.

    2015-01-01

    Aim: estimation of larch (Larix gmelinii) growth response to current climate changes. Location: permafrost area within the northern part of Central Siberia (approximately 65.8 deg N, 98.5 deg E). Method: analysis of dendrochronological data, climate variables, drought index SPEI, GPP (gross primary production) and EVI vegetation index (both Aqua/MODIS satellite derived), and soil water content anomalies (GRACE satellite measurements of equivalent water thickness anomalies, EWTA). Results: larch tree ring width (TRW) correlated with previous year August precipitation (r = 0.63), snow accumulation (r = 0.61), soil water anomalies (r = 0.79), early summer temperatures and water vapor pressure (r = 0.73 and r = 0.69, respectively), May and June drought index (r = 0.68-0.82). There are significant positive trends of TRW since late 1980s and GPP since the year 2000. Mean TRW increased by about 50%, which is similar to post-Little Ice Age warming. TRW correlated with GPP and EVI of larch stands (r = 0.68-0.69). Main conclusions: within the permafrost zone of central Siberia larch TRW growth is limited by early summer temperatures, available water from snowmelt, water accumulated within soil in the previous year, and permafrost thaw water. Water stress is one of the limiting factors of larch growth. Larch TRW growth and GPP increased during recent decades.

  7. MITA/STING: a central and multifaceted mediator in innate immune response.

    Science.gov (United States)

    Ran, Yong; Shu, Hong-Bing; Wang, Yan-Yi

    2014-12-01

    The recognition of nucleic acids is a general strategy used by the host to detect invading pathogens. Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. MITA can act both as a direct sensor of cyclic dinucleotides (CDNs) and as an adaptor for the recruitment of downstream signaling components. In both roles, MITA is part of signaling cascades that orchestrate innate immune defenses against various pathogens, including viruses, bacteria and parasites. Here, we highlight recent studies that have uncovered the molecular mechanisms of MITA-mediated signal transduction and regulation, and discuss some notable issues that remain elusive.

  8. Clinical features and early treatment response of central nervous system involvement in childhood acute lymphoblastic leukemia.

    Science.gov (United States)

    Levinsen, Mette; Taskinen, Mervi; Abrahamsson, Jonas; Forestier, Erik; Frandsen, Thomas L; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G; Lähteenmäki, Päivi M; Lausen, Birgitte; Vaitkevičienė, Goda; Asberg, Ann; Schmiegelow, Kjeld

    2014-08-01

    Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) remains a therapeutic challenge. To explore leukemia characteristics of patients with CNS involvement at ALL diagnosis, we analyzed clinical features and early treatment response of 744 patients on Nordic-Baltic trials. CNS status was classified as CNS1 (no CSF blasts), CNS2 ( 0.15). The 12-year event-free survival for patients with leukemic mass on neuroimaging did not differ from patients with negative or no scan (0.50 vs. 0.60; P = 0.7) or between patients with symptoms or signs suggestive of CNS leukemia and patients without such characteristics (0.50 vs. 0.61; P = 0.2). CNS involvement at diagnosis is associated with adverse prognostic features but does not indicate a less chemosensitive leukemia. © 2014 Wiley Periodicals, Inc.

  9. Semiarid watershed response in central New Mexico and its sensitivity to climate variability and change

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    E. R. Vivoni

    2009-06-01

    Full Text Available Hydrologic processes in the semiarid regions of the Southwest United States are considered to be highly susceptible to variations in temperature and precipitation characteristics due to the effects of climate change. Relatively little is known about the potential impacts of climate change on the basin hydrologic response, namely streamflow, evapotranspiration and recharge, in the region. In this study, we present the development and application of a continuous, semi-distributed watershed model for climate change studies in semiarid basins of the Southwest US. Our objective is to capture hydrologic processes in large watersheds, while accounting for the spatial and temporal variations of climate forcing and basin properties in a simple fashion. We apply the model to the Río Salado basin in central New Mexico since it exhibits both a winter and summer precipitation regime and has a historical streamflow record for model testing purposes. Subsequently, we use a sequence of climate change scenarios that capture observed trends for winter and summer precipitation, as well as their interaction with higher temperatures, to perform long-term ensemble simulations of the basin response. Results of the modeling exercise indicate that precipitation uncertainty is amplified in the hydrologic response, in particular for processes that depend on a soil saturation threshold. We obtained substantially different hydrologic sensitivities for winter and summer precipitation ensembles, indicating a greater sensitivity to more intense summer storms as compared to more frequent winter events. In addition, the impact of changes in precipitation characteristics overwhelmed the effects of increased temperature in the study basin. Nevertheless, combined trends in precipitation and temperature yield a more sensitive hydrologic response throughout the year.

  10. Impressions of Japan

    Institute of Scientific and Technical Information of China (English)

    Su; Fangyuan

    2013-01-01

    <正>The eight-day visit to Japan seemed to be a beautiful dream that ended before I woke up. However, in the dream I saw the future of China-Japan friendship. On March 4, flying to Japan, I thought all the way: "What kind of a country is Japan? Is it really as orderly and

  11. Short-Term Response of Sasa Dwarf Bamboo to a Change of Soil Nitrogen Fertility in a Forest Ecosystem in Northern Hokkaido, Japan.

    Science.gov (United States)

    Watanabe, Tsunehiro; Fukuzawa, Karibu; Shibata, Hideaki

    2016-04-14

    In forest ecosystems, a change of soil nitrogen (N) cycling after disturbance is regulated by various factors. Sasa dwarf bamboo (hereafter referred to as Sasa) is an understory plant that grows thickly on the forest floor in northern Hokkaido, Japan. However, the ecosystem function of Sasa after disturbances in the soil N cycling is not fully understood. The purpose of this study was to determine the short-term response of Sasa to a change of soil N fertility. Biomass, litterfall, litter decomposition, soil N pool, and N leaching from soil were measured in control, and low- (5 g N m(-2) year(-1)) and high-N (15 g N m(-2) year(-1)) addition plots. Sasa immobilized much N as the soil N fertility increased. However, the leaf N concentration in aboveground biomass did not increase, suggesting that the N in leaves was maintained because of the increase of leaf biomass. As a result, the decomposition and mineralization rates of the produced litter before and after N addition were comparable among plots, even though the soil inorganic N fertility increased greatly. These results suggest that immediate response of Sasa to an increase of soil inorganic N mitigates the excess N leaching from soil.

  12. Learning from Disaster Simulation Drills in Japan

    OpenAIRE

    World Bank

    2017-01-01

    Large-scale natural disasters are a frequent and common occurrence in Japan. Over the years, Japan has evolved its disaster management system to address all phases of a disaster: from disaster prevention, mitigation, and preparedness, to emergency response, recovery, and rehabilitation. This report consists of four parts: Introduction (Chapter 1, 2, 3), Simulation drills (Chapter 4, 5, 6, ...

  13. Mind-body response and neurophysiological changes during stress and meditation: central role of homeostasis.

    Science.gov (United States)

    Jerath, R; Barnes, V A; Crawford, M W

    2014-01-01

    Stress profoundly impacts quality of life and may lead to various diseases and conditions. Understanding the underlying physiological and neurological processes that take place during stress and meditation techniques may be critical for effectively treating stress-related diseases. The article examines a hypothetical physiological homeostatic response that compares and contrasts changes in central and peripheral oscillations during stress and meditation, and relates these to changes in the autonomic system and neurological activity. The authors discuss how cardiorespiratory synchronization, which occurs during the parasympathetic response and meditation, influences and modulates activity and oscillations of the brain and autonomic nervous system. Evidence is presented on how synchronization of cardiac and respiratory rates during meditation may lead to a homeostatic increase in cellular membrane potentials in neurons and other cells throughout the body. These potential membrane changes may underlie the reduced activity in the amygdala, and other cortical areas during meditation, and research examining these changes may foster better understanding of the restorative properties and health benefits of meditation.

  14. Testing bird response to roads on a rural environment: A case study from Central Italy

    Science.gov (United States)

    Morelli, Federico; Jerzak, Leszek; Pruscini, Fabio; Santolini, Riccardo; Benedetti, Yanina; Tryjanowski, Piotr

    2015-11-01

    The construction of roads is currently well spread in many parts of our world and impacts strongly on wildlife distribution. Some bird species avoid, while other prefer to be in the vicinity of these human structures. However, studies on roads effects on birds, in terms of strength or direction of these effects, are scarce. Therefore, in a study carried out in Central Italy we tested the responses of different bird species to roads at a local spatial scale, using generalized linear models (GLM). Analysis were conducted on a large dataset (more than 1400 sampled sites, mainly on rural environments). Both positive and negative effects of roads on birds were found for bird species of close or semi-close environments, while the negative effects of roads were negligible for bird species of open and semi-open environments. This fact suggest that roads can be a source of "functional heterogeneity" on semi-open environments, providing marginal habitats, hedgerows and residual vegetation typical of roadsides, offering breeding and feeding habitat for some bird species. The proposed methodology provide a useful explorative tool, in order to develop conservation policies to preserve the biodiversity, mainly in rural landscapes. The outputs of GLM can be used as inputs in ecological planning: direction and strength of the effects of roads on bird species are adequate to estimate the response of bird community, up front to the presence of new structures, or identifying which of them should be mitigated to reduce negative effects on the biodiversity.

  15. Central polar cap convection response to short duration southward Interplanetary Magnetic Field

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    P. T. Jayachandran

    Full Text Available Central polar cap convection changes associated with southward turnings of the Interplanetary Magnetic Field (IMF are studied using a chain of Canadian Advanced Digital Ionosondes (CADI in the northern polar cap. A study of 32 short duration (~1 h southward IMF transition events found a three stage response: (1 initial response to a southward transition is near simultaneous for the entire polar cap; (2 the peak of the convection speed (attributed to the maximum merging electric field propagates poleward from the ionospheric footprint of the merging region; and (3 if the change in IMF is rapid enough, then a step in convection appears to start at the cusp and then propagates antisunward over the polar cap with the velocity of the maximum convection. On the nightside, a substorm onset is observed at about the time when the step increase in convection (associated with the rapid transition of IMF arrives at the polar cap boundary.

    Key words: Ionosphere (plasma convection; polar ionosphere - Magnetospheric physics (solar wind - magnetosphere interaction

  16. Study of the central auditive pathway by encephalic trunk evoked e auditory responses (ear) in children with language retard

    OpenAIRE

    Gallardo, Manuel; Servicio de Otorrinolaringología, Hospital Central de la Fuerza Aérea del Perú; Vera, Carlos; Servicio de Otorrinolaringología, Hospital Central de la Fuerza Aérea del Perú

    2013-01-01

    Objetive: To determine the functional integrity of the brainstem auditory pathway by the auditive brainstem response (ABR) in language-retarded children without pathology in both the middle ear and central nervous system and no neonatal hearing loss risk factors. Design: Retrospective transversal study. Setting: Naval Medical Center and Air Force Central Hospital Otorhinolaryngology Services, Lima. Peru. Material and methods: Analysis of children’s ABR performed in the last ten years included...

  17. A Rearmed Japan: Implications.

    Science.gov (United States)

    1980-06-01

    Japan started its initial rearmament effort. Japan’s defense expenditures have fluctuated from near 3% of GNP to as low...Klein, Donald W. " Japan 1979: The Second Oil Crisis’ Asian Survey, January 1980. Lee, William T. "Soviet Defense Expenditures in an Era of SALT." United...relationship to the options Japan can take. In very general terms, Japan has two options: to solely rely on the D.S.-Japanese Mutual Defense Treaty for

  18. Effects of production circumstances on expected responses for growth and carcass traits to selection of bulls in Japan.

    Science.gov (United States)

    Hirooka, H; Groen, A F

    1999-05-01

    Economic values of growth and carcass traits in Japanese beef cattle for production systems with various types of integration of levels/ stages (cow-calf and feedlot segments and the integrated system) and production circumstances (including 20% higher genetic levels of the traits, management, and economic alternatives) were used to examine responses to selection. Discounted economic values with interest rates of 0, 4.2 (Japanese average), and 8.4% were obtained to investigate the effect of discounting on selection efficiency. Traits considered were daily gain in the feedlot, marbling score, birth weight, weaning weight, and mature weight. The effects of discounting were small. Correlated responses to selection were not always economically favorable for all situations. Selecting bulls for the base situation (i.e., the typical biological and economic conditions for the production of Japanese Black cattle) resulted in negative genetic changes in weaning weight and mature weight in the feedlot segment. Higher genetic levels of daily gain and weaning weight affected efficiency of selection. Although effects of management and economic alternatives on responses to selection were generally small, lighter market weight influenced responses to selection. The results indicate that predicted correlated responses to selection are sensitive to production systems and some production circumstances.

  19. Responses of Montane Forest to Climate Variability in the Central Himalayas of Nepal

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    Janardan Mainali

    2015-02-01

    Full Text Available Climate changes are having dramatic ecological impacts in mid- to high-latitude mountain ranges where growth conditions are limited by climatic variables such as duration of growing season, moisture, and ambient temperature. We document patterns of forest vegetative response for 5 major alpine forest communities to current climate variability in the central Himalayas of Nepal to provide a baseline for assessment of future changes, as well as offer some insight into the trajectory of these changes over time. We used mean monthly surface air temperature and rainfall and the monthly averaged normalized difference vegetation index (NDVI to compare relative vegetation productivity among forest types and in relation to both climatic variables. Because changes in temperature and precipitation are directly manifested as changes in phenology, we examined current vegetative responses to climate variability in an effort to determine which climate variable is most critical for different alpine forest types. Our results show that correlations differ according to vegetation type and confirm that both precipitation and temperature affect monthly NDVI values, though more significant correlations were found with temperature data. The temperature response was more consistent because at the maximum increased temperatures, there was still an ongoing increase in vegetative vigor. This indicates that temperature is still the major limiting factor for plant growth at higher-elevation sites. This part of the Himalayas has abundant moisture, and some forest types are already saturated in terms of growth in relation to precipitation. Clear increases in productivity are documented on the upper treeline ecotones, and these systems are likely to continue to have increasing growth rates.

  20. Effect of auditory training on the middle latency response in children with (central auditory processing disorder

    Directory of Open Access Journals (Sweden)

    E. Schochat

    2010-08-01

    Full Text Available The purpose of this study was to determine the middle latency response (MLR characteristics (latency and amplitude in children with (central auditory processing disorder [(CAPD], categorized as such by their performance on the central auditory test battery, and the effects of these characteristics after auditory training. Thirty children with (CAPD, 8 to 14 years of age, were tested using the MLR-evoked potential. This group was then enrolled in an 8-week auditory training program and then retested at the completion of the program. A control group of 22 children without (CAPD, composed of relatives and acquaintances of those involved in the research, underwent the same testing at equal time intervals, but were not enrolled in the auditory training program. Before auditory training, MLR results for the (CAPD group exhibited lower C3-A1 and C3-A2 wave amplitudes in comparison to the control group [C3-A1, 0.84 µV (mean, 0.39 (SD - standard deviation for the (CAPD group and 1.18 µV (mean, 0.65 (SD for the control group; C3-A2, 0.69 µV (mean, 0.31 (SD for the (CAPD group and 1.00 µV (mean, 0.46 (SD for the control group]. After training, the MLR C3-A1 [1.59 µV (mean, 0.82 (SD] and C3-A2 [1.24 µV (mean, 0.73 (SD] wave amplitudes of the (CAPD group significantly increased, so that there was no longer a significant difference in MLR amplitude between (CAPD and control groups. These findings suggest progress in the use of electrophysiological measurements for the diagnosis and treatment of (CAPD.

  1. Effect of auditory training on the middle latency response in children with (central) auditory processing disorder.

    Science.gov (United States)

    Schochat, E; Musiek, F E; Alonso, R; Ogata, J

    2010-08-01

    The purpose of this study was to determine the middle latency response (MLR) characteristics (latency and amplitude) in children with (central) auditory processing disorder [(C)APD], categorized as such by their performance on the central auditory test battery, and the effects of these characteristics after auditory training. Thirty children with (C)APD, 8 to 14 years of age, were tested using the MLR-evoked potential. This group was then enrolled in an 8-week auditory training program and then retested at the completion of the program. A control group of 22 children without (C)APD, composed of relatives and acquaintances of those involved in the research, underwent the same testing at equal time intervals, but were not enrolled in the auditory training program. Before auditory training, MLR results for the (C)APD group exhibited lower C3-A1 and C3-A2 wave amplitudes in comparison to the control group [C3-A1, 0.84 microV (mean), 0.39 (SD--standard deviation) for the (C)APD group and 1.18 microV (mean), 0.65 (SD) for the control group; C3-A2, 0.69 microV (mean), 0.31 (SD) for the (C)APD group and 1.00 microV (mean), 0.46 (SD) for the control group]. After training, the MLR C3-A1 [1.59 microV (mean), 0.82 (SD)] and C3-A2 [1.24 microV (mean), 0.73 (SD)] wave amplitudes of the (C)APD group significantly increased, so that there was no longer a significant difference in MLR amplitude between (C)APD and control groups. These findings suggest progress in the use of electrophysiological measurements for the diagnosis and treatment of (C)APD.

  2. Hominin responses to environmental changes during the Middle Pleistocene in central and southern Italy

    Directory of Open Access Journals (Sweden)

    R. Orain

    2013-03-01

    Full Text Available The palaeobotanical record of early Palaeolithic sites from Western Europe indicates that hominins settled in different kinds of environments. During the "mid-Pleistocene transition (MPT", from about 1 to 0.6 Ma, the transition from 41- to 100-ka dominant climatic oscillations, occurring within a long-term cooling trend, was associated with an aridity crisis which strongly modified the ecosystems. Starting from the MPT the more favourable climate of central and southern Italy provided propitious environmental conditions for long-term human occupations even during the glacial times. In fact, the human strategy of territory occupation was certainly driven by the availabilities of resources. Prehistoric sites such as Notarchirico (ca. 680–600 ka, La Pineta (ca. 600–620 ka, Guado San Nicola (ca. 380–350 ka or Ceprano (ca. 345–355 ka testify to a preferential occupation of the central and southern Apennines valleys during interglacial phases, while later interglacial occupations were oriented towards the coastal plains, as attested by the numerous settlements of the Roma Basin (ca. 300 ka. Faunal remains indicate that human subsistence behaviours benefited from a diversity of exploitable ecosystems, from semi-open to closed environments. In central and southern Italy, several palynological records have already illustrated the regional- and local-scale vegetation dynamic trends. During the Middle Pleistocene climate cycles, mixed mesophytic forests developed during the interglacial periods and withdrew in response to increasing aridity during the glacial episodes. New pollen data from the Boiano Basin (Molise, Italy attest to the evolution of vegetation and climate between MIS 13 and 9 (ca. 500 to 300 ka. In this basin the persistence of high edaphic humidity, even during the glacial phases, could have favoured the establishment of a refuge area for the arboreal flora and provided subsistence resources for the animal and hominin communities

  3. Hominin responses to environmental changes during the Middle Pleistocene in Central and Southern Italy

    Directory of Open Access Journals (Sweden)

    R. Orain

    2012-10-01

    Full Text Available The palaeobotanical record of early Palaeolithic sites from Western Europe indicates that hominins settled in different kinds of environments. During the "Mid-Pleistocene Transition (MPT", from about 1 to 0.6 Ma, the transition from 41-ka to 100-ka dominant climatic oscillations, occurring within a long-term cooling trend, was associated with an aridity crisis which strongly modified the ecosystems. Starting from the MPT the more favorable climate of central and southern Italy provided propitious environmental conditions for long-term human occupations even during the glacial times. In fact, the human strategy of territory occupation was certainly driven by the availabilities of resources. Prehistoric sites such as Notarchirico (ca. 680–600 ka, La Pineta (ca. 600–620 ka, Gaudo San Nicola (ca. 380–350 ka or Ceprano (ca. 345–355 ka testify to a preferential occupation of the central and southern Apennines valleys during interglacial phases, while later interglacial occupations were oriented towards the coastal plains, as attested by the numerous settlements of the Roma basin (ca. 300 ka. Faunal remains indicate that human subsistence behaviors benefited of a diversity of exploitable ecosystems, from semi-open to closed environments. In central and southern Italy, several palynological records have already illustrated the regional and local scale vegetation dynamic trends. During the Middle Pleistocene climate cycles, mixed mesophytic forests developed during the interglacial periods and withdrew in response to increasing aridity during the glacial episodes. New pollen data from the Boiano basin (Molise, Italy, attest to the evolution of vegetation and climate between OIS 13 and 9 (ca. 500 to 300 ka. In this basin, the persistence of high edaphic humidity, even during the glacial phases, could have favored the establishment of a refuge area for the arboreal flora and provided subsistence resources for the animal and hominin communities

  4. The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats.

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    Lukas Rüttiger

    Full Text Available Tinnitus is proposed to be caused by decreased central input from the cochlea, followed by increased spontaneous and evoked subcortical activity that is interpreted as compensation for increased responsiveness of central auditory circuits. We compared equally noise exposed rats separated into groups with and without tinnitus for differences in brain responsiveness relative to the degree of deafferentation in the periphery. We analyzed (1 the number of CtBP2/RIBEYE-positive particles in ribbon synapses of the inner hair cell (IHC as a measure for deafferentation; (2 the fine structure of the amplitudes of auditory brainstem responses (ABR reflecting differences in sound responses following decreased auditory nerve activity and (3 the expression of the activity-regulated gene Arc in the auditory cortex (AC to identify long-lasting central activity following sensory deprivation. Following moderate trauma, 30% of animals exhibited tinnitus, similar to the tinnitus prevalence among hearing impaired humans. Although both tinnitus and no-tinnitus animals exhibited a reduced ABR wave I amplitude (generated by primary auditory nerve fibers, IHCs ribbon loss and high-frequency hearing impairment was more severe in tinnitus animals, associated with significantly reduced amplitudes of the more centrally generated wave IV and V and less intense staining of Arc mRNA and protein in the AC. The observed severe IHCs ribbon loss, the minimal restoration of ABR wave size, and reduced cortical Arc expression suggest that tinnitus is linked to a failure to adapt central circuits to reduced cochlear input.

  5. Application of UAV-SfM photogrammetry and aerial lidar to a disastrous flood: repeated topographic measurement of a newly formed crevasse splay of the Kinu River, central Japan

    Science.gov (United States)

    Izumida, Atsuto; Uchiyama, Shoichiro; Sugai, Toshihiko

    2017-09-01

    Geomorphic impacts of a disastrous crevasse splay that formed in September 2015 and its post-formation modifications were quantitatively documented by using repeated, high-definition digital surface models (DSMs) of an inhabited and cultivated floodplain of the Kinu River, central Japan. The DSMs were based on pre-flood (resolution: 2 m) and post-flood (resolution: 1 m) aerial light detection and ranging (lidar) data from January 2007 and September 2015, respectively, and on structure-from-motion (SfM) photogrammetry data (resolution: 3.84 cm) derived from aerial photos taken by an unmanned aerial vehicle (UAV) in December 2015. After elimination of systematic errors among the DSMs and down-sampling of the SfM-derived DSM, elevation changes on the order of 10-1 m - including not only topography but also growth of vegetation, vanishing of flood waters, and restoration and repair works - were detected. Comparison of the DSMs showed that the volume eroded by the flood was more than twice the deposited volume in the area within 300-500 m of the breached artificial levee, where the topography was significantly affected. The results suggest that DSMs based on a combination of UAV-SfM and lidar data can be used to quantify, rapidly and in rich detail, topographic changes on floodplains caused by floods.

  6. Fate of an Oceanic Island-arc at the Collision Zone: Insight From a Modern Case at the Izu Collision Zone, Central Japan

    Science.gov (United States)

    Aoike, K.

    2003-12-01

    Arc-arc or arc-continent collision zone, which separates an arc crust into materials to be left on the earth_fs surface and to be returned to the mantle, is regarded as the final disposal place of the subduction factory product. Mass balance across the collision boundary, therefore, should have great significance in the processes of continental growth and mantle evolution. The Izu Collision Zone (ICZ) located at the conjunction of the Honshu arc and the Izu-Bonin arc (IBA), is a place of ongoing orthogonal arc-arc collision, where the middle to upper crust of the northern IBA is exposed on land as accretionary terranes. The IBA-ICZ system is much advantageous for elucidating the mass balance, because that the product is simple and fresh and the flow from manufacture to disposal is quite clear. Across arc variation of buoyancy and rheological state of the lithosphere controlled principally by geothermal gradient would regulate the regime of collision tectonics. Crust-scale accretion is taking place associated with conspicuous crustal shortening and thickening in the central ICZ where the active arc that is about 100 km wide and 20 km thick is colliding. By contrast, almost the whole arc crust is subducting, leaving the off-scraped sediments as accretionary prisms in the eastern and western areas where the inactive forearc and backarc, totally 200 km wide and averagely 14 km thick, are colliding. Based on the land geology and existing seismic structure, crustal volume of the accreted IBA is estimated for the line along the axis of the ICZ and another line passing through the Tanzawa Terrane situated eastward 30 km apart from the axis. The estimation indicates that the volume of the Tanzawa line is significantly smaller (16 %) than that of the axis, in spite of being very close. This difference is explainable, if the Philippine Sea Plate slab including expected aseismic part is accompanied with 7 km thick subducted arc crust. This result of calculation implies that

  7. What American Students Want to Know about Japan.

    Science.gov (United States)

    Bullard, Betty; And Others

    1981-01-01

    Presents and discusses five sample topics out of 25 covered in the booklet entitled "What I Want to Know about Japan." The booklet was published by the Japan Information Center in New York in response to a survey of Japan-related knowledge of seventh grade students throughout the United States. Questions focus on houses, teenagers, marriage,…

  8. Japan Tobacco International: To 'be the most successful and respected tobacco company in the world'.

    Science.gov (United States)

    MacKenzie, Ross; Eckhardt, Jappe; Widyati Prastyani, Ade

    2017-03-01

    Japan Tobacco International (JTI) is the international division of Japan Tobacco Incorporated, and the world's third largest transnational tobacco company. Founded in 1999, JTI's rapid growth has been the result of a global business strategy that potentially serves as a model for other Asian tobacco companies. This paper analyses Japan Tobacco Incorporated's global expansion since the 1980s in response to market opening, foreign competition, and declining share of a contracting domestic market. Key features of its global strategy include the on-going central role and investment by the Japanese government, and an expansion agenda based on mergers and acquisitions. The paper also discusses the challenges this global business strategy poses for global tobacco control and public health. This paper is part of the special issue 'The Emergence of Asian Tobacco Companies: Implications for Global Health Governance'.

  9. Epidemiological evaluation of cat health at a first-response animal shelter in Fukushima, following the Great East Japan Earthquakes of 2011.

    Science.gov (United States)

    Tanaka, Aki; Kass, Philip H; Martinez-Lopez, Beatriz; Hayama, Shinichi

    2017-01-01

    The Great East Japan Earthquakes of March 11, 2011 caused immense harm to the community and subsequent nuclear accident in Fukushima Prefecture extended the damage. Local residents were forced to evacuated without pets and the left behind animals were rescued from the restricted zone one month later. Unplanned animal rescue and unregulated sheltering caused secondary damage to animals such as disease epidemics at impounded animal shelter. The purpose of this study was to retrospectively evaluate the incidence of upper respiratory infection (URI) and diarrhea in cats at the first response animal shelter in Fukushima, and investigate factors affecting the duration of disease and determinants of treatments performed. Eighty percent and 59% of impounded cats developed URI, 71% and 54% of cats developed diarrhea, and 91% and 83% of cats had at least one disease in 2011 and 2012, respectively. Uses of multiple drug administration (more than five drugs) was associated with prolonged URI and diarrhea. Multiple antibiotics, antihistamines, interferon, and steroids were associated with relapse of and prolonged URI. Developing a standardized treatment protocol for commonly observed diseases at Japanese animal shelters to prevent and control diseases, to promote animal welfare, and protect public health in the face of future disasters is overdue.

  10. Community response to construction noise in three central cities of Zhejiang province, China.

    Science.gov (United States)

    Liu, Yong; Xia, Bo; Cui, Caiyun; Skitmore, Martin

    2017-11-01

    As a common source of environmental noise in China and many developing countries worldwide, construction work provokes many complaints and deterioration in acoustic climate quality. This paper describes research to obtain an improved understanding of people's community response to, and evaluation of, construction noise in three central cities of Zhejiang province, China. This involved carrying out a social survey using standard questionnaires developed by the International Commission on Biological Effects of Noise (ICBEN). A dose-response relationship model is established using a quadratic polynomial regression analysis based on construction noise exposure measurements from 40 construction sites in Hangzhou, Ningbo and Wenzhou. The results of the study indicate that the majority of people have a negative attitude to construction noise; the noise ranges between 60 dB and 80 dB (compared with 50 dB-70 dB traffic noise in Tianjin), with the percentage of highly annoyed people affected increasing from 15%-20% to 30%-40% over the range. There also different levels of annoyance depending on the time of day, and the location and activities of those affected. Other cultural differences are also apparent both between Ningbo/Wenzhou and the more urbane citizens of Hangzhou, and the Chinese people and their more noise-tolerant EU and Vietnam counterparts. The findings of this study provide a new perspective for the study of construction noise that can help local governments have an improved understanding of how residents react to construction noise for the purpose of selecting construction noise-mitigation projects and introducing construction noise-control regulations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Mangshan loess on China’s Central Plain and its response to tectonic movement and climate

    Institute of Scientific and Technical Information of China (English)

    吴锡浩; 蒋复初; 肖华国; 薛滨; 孙东怀

    1999-01-01

    The Mangshan loess on China’s Central Plain, located on the transitional zone between the uplifting Loess Plateau and the subsiding North China Plain, is a proximal sandy loess transported from the fanhead of alluvial fan in the lower reaches of the Yellow River and has recorded the eoupting effect of the tectonics and climate over the last 200 ka. An abrupt environmental change indicated by the abrupt rise of deposit rate in the late penultimate glaciation, about 150 ka BP, took place; that is, the Yellow River downcut and moved eastwards through the Sanmenxia Gorge and transported abundant materials from the Loess Plateau to form paleosol S1 with a thickness of 15.7 m and loess L1 with a thickness of 77.3 m. The loess-paleosol sequence at Mangshan has not only recorded detailed climate responses of this area to the East Asian monsoon, but also refleets the tectonogenetie environmental effect caused by the trunk stream of the Yellow River cutting through Sanmenxia Gorge into sea.

  12. Surface Mining and Reclamation Effects on Flood Response of Watersheds in the Central Appalachian Plateau Region

    Science.gov (United States)

    Ferrari, J. R.; Lookingbill, T. R.; McCormick, B.; Townsend, P. A.; Eshleman, K. N.

    2009-01-01

    Surface mining of coal and subsequent reclamation represent the dominant land use change in the central Appalachian Plateau (CAP) region of the United States. Hydrologic impacts of surface mining have been studied at the plot scale, but effects at broader scales have not been explored adequately. Broad-scale classification of reclaimed sites is difficult because standing vegetation makes them nearly indistinguishable from alternate land uses. We used a land cover data set that accurately maps surface mines for a 187-km2 watershed within the CAP. These land cover data, as well as plot-level data from within the watershed, are used with HSPF (Hydrologic Simulation Program-Fortran) to estimate changes in flood response as a function of increased mining. Results show that the rate at which flood magnitude increases due to increased mining is linear, with greater rates observed for less frequent return intervals. These findings indicate that mine reclamation leaves the landscape in a condition more similar to urban areas rather than does simple deforestation, and call into question the effectiveness of reclamation in terms of returning mined areas to the hydrological state that existed before mining.

  13. Response of arid ecosystems to the Holocene climate variability along west and central Mediterranean gradients.

    Science.gov (United States)

    Jaouadi, Sahbi; Combourieu Nebout, Nathalie; Azuara, Julien; Lebreton, Vincent

    2017-04-01

    Decadal to millennial climate variability is a common feature recorded by environmental series. However interconnections between climate forcing (i.e. insolation, thermohaline circulation) and large atmospheric circulation patterns (i.e. North Atlantic Oscillation, Mediterranean Oscillation, Monsoon) still remain poorly understood considering their respective impacts on the global climate mechanisms. In the Mediterranean area, joint climatic influences from high temperate and low subtropical latitudes result in a high sensitivity of ecosystems to climate changes and especially to extreme events. Several vegetation records illustrate millennial changes in Mediterranean. Nevertheless notable discrepancies in the environmental response arise between Mediterranean edges (east vs west, north vs south). The new paleoenvironmental record from Sebkha Boujmel (33°N, southern Tunisia) covers the last 8kyr and exhibits eight humid/arid fluctuations with cyclic expansion of the desert, related to Middle and Late Holocene rapid climate changes (RCC) occurring at a centennial scale. Sebkha Boujmel record is replaced in the wider context of west Mediterranean and northern hemisphere. Asynchronies and disparity of the Mediterranean RCC occurrence documents north-south and west-east climate gradients in the west Mediterranean and pinpoint Sebkha Boujmel as the single vegetation record tracing as many climate events during the last 8kyr. Indeed the high sensitivity of arid environments triggers the prompt reaction of the southern Tunisian vegetation to Holocene RCC however tenuous. Pattern of RCC geographical occurrence in west and central Mediterranean is interpreted in the light of climate forcings involved for the Holocene centennial variability.

  14. Canopy Transpiration and Stomatal Responses to Prolonged Drought by a Dominant Desert Species in Central Asia

    Directory of Open Access Journals (Sweden)

    Daxing Gu

    2017-06-01

    Full Text Available In arid and semiarid lands, canopy transpiration and its dynamics depend largely on stomatal sensitivity to drought. In this study, the sap flow of a dominant species, Haloxylon ammodendron growing in Central Asian deserts, was monitored using Granier-type sensors, from which the canopy stomatal conductance was derived. The responses of canopy transpiration and stomatal conductance to environmental variables during the second half of the growing season, when annual prolonged drought occurred, was analyzed for four continuous years, from 2013 to 2016. A soil water content (SWC of 3% was identified as the lower soil water threshold for this species, below which the plant lost the ability for stomatal regulation on water loss and suffered the risk of mortality. Above this threshold, the sensitivity of canopy transpiration to vapor pressure deficit, VPD (K, was linearly correlated with SWC, which mainly resulted from different stomatal behaviors at varying drought intensities. Stomatal sensitivity to VPD (m/Gsref increased linearly with soil moisture deficit, inducing a shift from more anisohydric to a more isohydric stomatal behavior. The flexibility of stomatal behavior regarding soil drought was one key element facilitating the survival of H. ammodendron in such an extreme dry environment.

  15. Measurement and Analysis of Olfactory Responses with the Aim of Establishing an Objective Diagnostic Method for Central Olfactory Disorders

    Science.gov (United States)

    Uno, Tominori; Wang, Li-Qun; Miwakeichi, Fumikazu; Tonoike, Mitsuo; Kaneda, Teruo

    In order to establish a new diagnostic method for central olfactory disorders and to identify objective indicators, we measured and analyzed brain activities in the parahippocampal gyrus and uncus, region of responsibility for central olfactory disorders. The relationship between olfactory stimulation and brain response at region of responsibility can be examined in terms of fitted responses (FR). FR in these regions may be individual indicators of changes in brain olfactory responses. In the present study, in order to non-invasively and objectively measure olfactory responses, an odor oddball task was conducted on four healthy volunteers using functional magnetic resonance imaging (fMRI) and a odorant stimulator with blast-method. The results showed favorable FR and activation in the parahippocampal gyrus or uncus in all subjects. In some subjects, both the parahippocampal gyrus and uncus were activated. Furthermore, activation was also confirmed in the cingulate gyrus, middle frontal gyrus, precentral gyrus, postcentral gyrus, superior temporal gyrus and insula. The hippocampus and uncus are known to be involved in the olfactory disorders associated with early-stage Alzheimer's disease and other olfactory disorders. In the future, it will be necessary to further develop the present measurement and analysis method to clarify the relationship between central olfactory disorders and brain activities and establish objective indicators that are useful for diagnosis.

  16. Assessment of local seismic response of the Stracciacappa maar (Central Italy)

    Science.gov (United States)

    Moscatelli, Massimiliano; Simionato, Maurizio; Gaudiosi, Iolanda; Sottili, Gianluca; Pagliaroli, Alessandro; Sirianni, Pietro; Pileggi, Domenico; Avalle, Alessandra; Giallini, Silvia; Razzano, Roberto; Mancini, Marco; Vignaroli, Gianluca; Piscitelli, Sabatino; Bellanova, Jessica; Calamita, Giuseppe; Perrone, Angela; Lanzo, Giuseppe

    2016-04-01

    In this work, we face the definition of a subsoil model aimed at the local seismic response assessment of the Stracciacappa maar (Sabatini Volcanic District, central Italy) (e.g., De Rita and Zanetti, 1986; Marra et al., 2014). The pyroclastic succession of Stracciacappa records two main hydromagmatic eruptive phases ended about 0.09 Ma ago (e.g., Sottili et al., 2010). The preserved crater, with a diameter of about 1500 meters and a crater floor of about 30-40 m, hosted a lake until it was drained in AD 1834. In the framework of the cooperation between CNR IGAG and Italian Department of Civil Protection (DPC) of the Presidency of Council of Ministers (DPC funds 2014), a multidisciplinary approach including detailed stratigraphic and geophysical study has been carried out in the Stracciacappa maar and surrounding areas. New geological map and cross sections illustrate the complex geometric relationships between the thick pyroclastic surge succession, showing diffuse sandwave structures, and even meter-sized lava ballistic. A composite interdigitation between lacustrine and epiclastic debris sediments fills the crater floor. A continuous coring borehole was drilled inside the crater, 45 meters deep from the wellhead, with sampling of undisturbed samples. In addition, four MASW and one SCPTU test were carried out, in order to define the velocity profile of the s-waves within the lacustrine deposits. This Vs profile was then extended at higher depths by using the results of four 2D seismic passive arrays. Moreover, in order to define the resonance frequency of sedimentary covers via the HVSR technique, twenty-eight measurements were carried out with digital sensor Tromino® and seven measurements were performed with a Lennartz® Le-3D/5s sensor with Lennartz Marslite® digitizer. Finally, three electrical resistivity tomography tests, with a total length of about 3500 meters, were carried out with the purpose of constraining the subsoil model. Regarding the non linear

  17. Maize Response to Fertilizer Dosing at Three Sites in the Central Rift Valley of Ethiopia

    Directory of Open Access Journals (Sweden)

    Getachew Sime

    2014-09-01

    Full Text Available This study examines the agronomic response, efficiency and profitability of fertilizer microdosing in maize. An experiment with the following treatments was conducted: control without fertilizer, microdosing treatments, with the rate of 27 + 27, 53 + 53 and 80 + 80 kg ha−1, and banding of fertilizer with 100 + 100 kg ha−1 of di ammonium phosphate (DAP + urea, applied at planting and jointing, respectively. The treatments were arranged in a randomized complete block design with four replications. The experiment was conducted during the 2011/2012 and 2012/2013 cropping seasons at Ziway, Melkassa and Hawassa in the semiarid central rift valley region of Ethiopia. Compared to the control, the fertilizer treatments had higher yield and fertilizer use efficiency (FUE profitably. The 27 + 27 kg ha−1 fertilizer rate increased the grain yield by 19, 45 and 46% at Hawassa, Ziway and Melkassa, respectively, and it was equivalent to the higher rates. The value cost ratio (VCR was highest with the lowest fertilizer rate, varying between seven and 11 in the treatment with 27 + 27 kg ha−1, but two and three in the banding treatment. Similarly, FUE was highest with the lowest fertilizer rate, varying between 23 and 34 kg kg−1 but 7 and 8 kg kg−1 in the banding treatment. The improved yield, FUE, VCR and gross margin in maize with microdosing at the 27 + 27 kg ha−1 of DAP + urea rate makes it low cost, low risk, high yielding and profitable. Therefore, application of this particular rate in maize may be an option for the marginal farmers in the region with similar socioeconomic and agroecological conditions.

  18. Response of deciduous trees spring phenology to recent and projected climate change in Central Lithuania

    Science.gov (United States)

    Juknys, Romualdas; Kanapickas, Arvydas; Šveikauskaitė, Irma; Sujetovienė, Gintarė

    2016-10-01

    The analysis of long-term time series of spring phenology for different deciduous trees species has shown that leaf unfolding for all the investigated species is the most sensitive to temperatures in March and April and illustrates that forcing temperature is the main driver of the advancement of leaf unfolding. Available chilling amount has increased by 22.5 % over the last 90 years, indicating that in the investigated geographical region there is no threat of chilling shortage. The projection of climatic parameters for Central Lithuania on the basis of three global circulation models has shown that under the optimistic climate change scenario (RCP 2.6) the mean temperature tends to increase by 1.28 °C and under the pessimistic scenario (RCP 8.5) by 5.03 °C until the end of the current century. Recently, different statistical models are used not only to analyze but also to project the changes in spring phenology. Our study has shown that when the data of long-term phenological observations are available, multiple regression models are suitable for the projection of the advancement of leaf unfolding under the changing climate. According to the RCP 8.5 scenario, the projected advancement in leaf unfolding for early-season species birch consists of almost 15 days as an average of all three used GSMs. Markedly less response to the projected far future (2071-2100), climate change is foreseen for other investigated climax species: -9 days for lime, 10 days for oak, and 11 days for maple.

  19. Response of foster grapefruit (Citrus paradisi Macf. to organic and inorganic fertilization in central Sudan

    Directory of Open Access Journals (Sweden)

    Abdalla A.M. Elhassan

    2011-06-01

    Full Text Available The response of Foster grapefruit (Citrus paradisi Macf. to organic and inorganic fertilization in Sennar area (13°37′N–33°37′E representing central Sudan, was studied for two successive seasons (2003/2004 and 2004/2005. Urea, sheep manure and terra-sorb (as foliar at the rates of 2.17 kg/tree/year, 20 kg/tree/year and 200 ml/100 L water, respectively, and their combinations were applied to 18 years old trees to determine their effects on fruit yield and quality. The layout was a randomized complete block design replicated three times. Results indicated that all treatments significantly increased average yield over control with inconsistent effects on fruit quality parameters. Trees received urea at the rate of 2.17 kg/tree/year, yielded thick peel fruits of reduced vitamin C. Sheep manure at the rate of 20 kg/tree/year resulted in dark green fruits of thick peel. The foliar treated trees at the rate of 200 ml/100 L water gave little thick peel fruits of lower total soluble solids, low % titrable acidity and low vitamin C. The best fruits reflected by color, thinner peel, high % TSS and high vitamin C were obtained from urea + sheep manure treatment. Application of urea with foliar gave green large fruits. Small fruits of intensive green color on surface and low titrable acidity were recorded by combination of sheep manure and foliar. Application of the three fertilizers together gave fruits of dark green color on surface and thick peel. Therefore, application of 2.17 kg urea + 20 kg sheep manure/tree/year is recommended to Foster grapefruit trees in Sennar area and areas of similar environmental conditions.

  20. Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system.

    Science.gov (United States)

    Jiang, Xiu-Qing; Cao, Chang-Yu; Li, Zhao-Yang; Li, Wei; Zhang, Cong; Lin, Jia; Li, Xue-Nan; Li, Jing-Long

    2017-04-01

    Selenium (Se) incorporated in selenoproteins as selenocysteine and supports various important cellular and organismal functions. We recently reported that chicken brain exhibited high priority for Se supply and retention under conditions of dietary Se deficiency and supernutrition Li et al. (2012) . However, the selenotranscriptome expressions and their response to Se status in chicken central nervous system (CNS) are unclear. To better understand the relationship of Se homeostasis and selenoproteins expression in chicken CNS, 1day-old HyLine White chickens were fed a low Se diet (Se-L, 0.028mg/g) supplemented with 4 levels of dietary Se (0 to 5.0mgSe/kg) as Na2SeO3 for 8weeks. Then chickens were dissected for getting the CNS, which included cerebral cortex, cerebellum, thalamus, bulbus cinereus and marrow. The expressions of selenoproteome which have 24 selenoproteins were detected by the quantitative real-time PCR array. The concept of a selenoprotein hierarchy was developed and the hierarchy of different regions in chicken CNS was existence, especially cerebral cortex and bulbus cinereus. The expression of selenoproteins has a hierarch while changing Se content, and Selenoprotein T (Selt), Selenoprotein K (Selk), Selenoprotein W (Selw), Selenoprotein U (Selu), Glutathione peroxidase 3 (Gpx3), Glutathione peroxidase 4 (Gpx4), Selenoprotein P (Sepp1), Selenoprotein O (Selo), Selenoprotein 15 (Sel15), Selenoprotein N (Seln), Glutathione peroxidase 2 (Gpx2) and Selenoprotein P 2 (Sepp2) take more necessary function in the chicken CNS. Therefore, we hypothesize that hierarchy of regulated the transcriptions of selenoproteome makes an important role of CNS Se metabolism and transport in birds. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Hydrologic response in karstic-ridge wetlands to rainfall and evapotranspiration, central Florida, 2001-2003

    Science.gov (United States)

    Knowles, Leel; Phelps, G.G.; Kinnaman, Sandra L.; German, Edward R.

    2005-01-01

    Two internally drained karstic wetlands in central Florida-Boggy Marsh at the Hilochee Wildlife Management Area and a large unnamed wetland at the Lyonia Preserve-were studied during 2001-03 to gain a better understanding of the net-recharge function that these wetlands provide, the significance of exchanges with ground water with regard to wetland water budgets, and the variability in wetland hydrologic response to a range of climate conditions. These natural, relatively remote and unaltered wetlands were selected to provide a baseline of natural wetland hydrologic variability to which anthropogenic influences on wetland hydrology could be compared. Large departures from normal rainfall during the study were fortuitous, and allowed monitoring of hydrologic processes over a wide range of climate conditions. Wetland responses varied greatly as a result of climate conditions that ranged from moderate drought to extremely moist. Anthropogenic activities influenced water levels at both study sites; however, because these activities were brief relative to the duration of the study, sufficient data were collected during unimpacted periods to allow for the following conclusions to be made. Water budgets developed for Boggy Marsh and the Lyonia large wetland showed strong similarity between the flux terms of rainfall, evaporation, net change in storage, and the net ground-water exchange residual. Runoff was assumed to be negligible. Of the total annual flux at Boggy Marsh, rainfall accounted for 45 percent; evaporation accounted for 25 percent; net change in storage accounted for 25 percent; and the net residual accounted for 5 percent. At the Lyonia large wetland, rainfall accounted for 44 percent; evaporation accounted for 29 percent; net change in storage accounted for 21 percent; and the net residual accounted for 6 percent of the total annual flux. Wetland storage and ground-water exchange were important when compared to the total water budget at both wetlands. Even

  2. Academic Libraries in Japan

    Science.gov (United States)

    Cullen, Rowena; Nagata, Haruki

    2008-01-01

    Academic libraries in Japan are well resourced by international standards, and support Japan's internationally recognized research capability well, but there are also ways in which they reflect Japan's strong bureaucratic culture. Recent changes to the status of national university libraries have seen a new interest in customer service, and…

  3. Academic Libraries in Japan

    Science.gov (United States)

    Cullen, Rowena; Nagata, Haruki

    2008-01-01

    Academic libraries in Japan are well resourced by international standards, and support Japan's internationally recognized research capability well, but there are also ways in which they reflect Japan's strong bureaucratic culture. Recent changes to the status of national university libraries have seen a new interest in customer service, and…

  4. Get Oriented: Study Japan.

    Science.gov (United States)

    Parramore, Barbara M.

    1981-01-01

    Recommends that students in social studies classes be exposed to a study of Japan because of the wide array of contrasts possible between Japan and the United States. Information is presented on Japan's modernization, global status, language, decision-making processes, and ancient traditions. (DB)

  5. Development of cancer cooperative groups in Japan.

    Science.gov (United States)

    Fukuda, Haruhiko

    2010-09-01

    Investigator-initiated clinical trials are essential for improving the standard of care for cancer patients, because pharmaceutical companies do not conduct trials that evaluate combination chemotherapy using drugs from different companies, surgery, radiotherapy or multimodal treatments. Government-sponsored cooperative groups have played a vital role in developing cancer therapeutics since the 1950s in the USA; however, the establishment of these groups in Japan did not take place until 30 years later. Methodological standards for multicenter cancer clinical trials were established in the 1980s by the National Cancer Institute and cooperative groups. The Japan Clinical Oncology Group, one of the largest cooperative groups in the country, was instituted in 1990. Its data center and operations office, formed during the 1990s, applied the standard methods of US cooperative groups. At present, the Japan Clinical Oncology Group consists of 14 subgroups, a Data Center, an Operations Office, nine standing committees and an Executive Committee represented by the Japan Clinical Oncology Group Chair. Quality control and quality assurance at the Japan Clinical Oncology Group, including regular central monitoring, statistical methods, interim analyses, adverse event reporting and site visit audit, have complied with international standards. Other cooperative groups have also been established in Japan since the 1980s; however, nobody figures out all of them. A project involving the restructuring of US cooperative groups has been ongoing since 2005. Learning from the success of this project will permit further progress of the cancer clinical trials enterprise in Japan.

  6. Response of zooplankton to physical changes in the environment: coastal upwelling along central west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Madhupratap, M.; Nair, S.R.S.; Haridas, P.; Padmavati, G.

    Research 413-426 Fort Lauderdale, Florida Response of Zooplankton to Physical Changes in the Environment: Coastal Upwelling Along the Central West Coast of India b~ M. Madhupratap,t S.R. Sreekumaran Nair/ P. Haridas,* and Gadi PadmavatP tNational Institute... of zooplankton to physical changes in the environment: COlistlil upwelling along the central west coast of India. Journal of Coastal Research, 6(2), 413-426. Fort Lauderdale (Florida). ISSN 0749-0208. Zooplankton composition lind abundance were studied in a...

  7. Japan Trail '83: American Art Education Odyssey to the Orient.

    Science.gov (United States)

    Dobbs, Stephen Mark

    1983-01-01

    Five American middle school students went to Japan for two weeks in 1983 as ambassadors for American art education. Art education in Japan is much more centralized than in America. In addition to school study, children are exposed to traditional arts like the tea ceremony, calligraphy, and ikebana. (CS)

  8. Japan Trail '83: American Art Education Odyssey to the Orient.

    Science.gov (United States)

    Dobbs, Stephen Mark

    1983-01-01

    Five American middle school students went to Japan for two weeks in 1983 as ambassadors for American art education. Art education in Japan is much more centralized than in America. In addition to school study, children are exposed to traditional arts like the tea ceremony, calligraphy, and ikebana. (CS)

  9. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint.

    Directory of Open Access Journals (Sweden)

    James J Burston

    Full Text Available Osteoarthritis (OA of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impacts upon the central processing of pain is crucial for the identification of novel analgesic targets/new therapeutic strategies. Inhibitory cannabinoid 2 (CB2 receptors attenuate peripheral immune cell function and modulate central neuro-immune responses in models of neurodegeneration. Systemic administration of the CB2 receptor agonist JWH133 attenuated OA-induced pain behaviour, and the changes in circulating pro- and anti-inflammatory cytokines exhibited in this model. Electrophysiological studies revealed that spinal administration of JWH133 inhibited noxious-evoked responses of spinal neurones in the model of OA pain, but not in control rats, indicating a novel spinal role of this target. We further demonstrate dynamic changes in spinal CB2 receptor mRNA and protein expression in an OA pain model. The expression of CB2 receptor protein by both neurones and microglia in the spinal cord was significantly increased in the model of OA. Hallmarks of central sensitization, significant spinal astrogliosis and increases in activity of metalloproteases MMP-2 and MMP-9 in the spinal cord were evident in the model of OA pain. Systemic administration of JWH133 attenuated these markers of central sensitization, providing a neurobiological basis for analgesic effects of the CB2 receptor in this model of OA pain. Analysis of human spinal cord revealed a negative correlation between spinal cord CB2 receptor mRNA and macroscopic knee chondropathy. These data provide new clinically relevant evidence that joint damage and spinal CB2 receptor expression are correlated combined with converging pre-clinical evidence that activation of CB2 receptors inhibits central sensitization and its contribution to the manifestation

  10. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint.

    Science.gov (United States)

    Burston, James J; Sagar, Devi Rani; Shao, Pin; Bai, Mingfeng; King, Emma; Brailsford, Louis; Turner, Jenna M; Hathway, Gareth J; Bennett, Andrew J; Walsh, David A; Kendall, David A; Lichtman, Aron; Chapman, Victoria

    2013-01-01

    Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impacts upon the central processing of pain is crucial for the identification of novel analgesic targets/new therapeutic strategies. Inhibitory cannabinoid 2 (CB2) receptors attenuate peripheral immune cell function and modulate central neuro-immune responses in models of neurodegeneration. Systemic administration of the CB2 receptor agonist JWH133 attenuated OA-induced pain behaviour, and the changes in circulating pro- and anti-inflammatory cytokines exhibited in this model. Electrophysiological studies revealed that spinal administration of JWH133 inhibited noxious-evoked responses of spinal neurones in the model of OA pain, but not in control rats, indicating a novel spinal role of this target. We further demonstrate dynamic changes in spinal CB2 receptor mRNA and protein expression in an OA pain model. The expression of CB2 receptor protein by both neurones and microglia in the spinal cord was significantly increased in the model of OA. Hallmarks of central sensitization, significant spinal astrogliosis and increases in activity of metalloproteases MMP-2 and MMP-9 in the spinal cord were evident in the model of OA pain. Systemic administration of JWH133 attenuated these markers of central sensitization, providing a neurobiological basis for analgesic effects of the CB2 receptor in this model of OA pain. Analysis of human spinal cord revealed a negative correlation between spinal cord CB2 receptor mRNA and macroscopic knee chondropathy. These data provide new clinically relevant evidence that joint damage and spinal CB2 receptor expression are correlated combined with converging pre-clinical evidence that activation of CB2 receptors inhibits central sensitization and its contribution to the manifestation of chronic OA

  11. Involvement of central alpha1- and alpha2-adrenoceptors on cardiovascular responses to moxonidine.

    Science.gov (United States)

    Moreira, Thiago S; Takakura, Ana C; Menani, José V; Colombari, Eduardo

    2007-06-01

    In the present study we compared the effects produced by moxonidine (alpha2-adrenoceptor/imidazoline agonist) injected into the 4th cerebral ventricle and into the lateral cerebral ventricle on mean arterial pressure, heart rate and on renal, mesenteric and hindquarter vascular resistances, as well as the possible action of moxonidine on central alpha1- or alpha2-adrenoceptors to produce cardiovascular responses. Male Holtzman rats (n=7-8) anesthetized with urethane (0.5 g/kg, intravenously-i.v.) and alpha-chloralose (60 mg/kg, i.v.) were used. Moxonidine (5, 10 and 20 nmol) injected into the 4th ventricle reduced arterial pressure (-19+/-5, -30+/-7 and -43+/-8 mmHg vs. vehicle: 2+/-4 mmHg), heart rate (-10+/-6, -16+/-7 and -27+/-9 beats per minute-bpm, vs. vehicle: 4+/-5 bpm), and renal, mesenteric and hindquarter vascular resistances. Moxonidine (5, 10 and 20 nmol) into the lateral ventricle only reduced renal vascular resistance (-77+/-17%, -85+/-13%, -89+/-10% vs. vehicle: 3+/-4%), without changes on arterial pressure, heart rate and mesenteric and hindquarter vascular resistances. Pre-treatment with the selective alpha2-adrenoceptor antagonist yohimbine (80, 160 and 320 nmol) injected into the 4th ventricle attenuated the hypotension (-32+/-5, -25+/-4 and -12+/-6 mmHg), bradycardia (-26+/-11, -23+/-5 and -11+/-6 bpm) and the reduction in renal, mesenteric and hindquarter vascular resistances produced by moxonidine (20 nmol) into the 4th ventricle. Pre-treatment with yohimbine (320 nmol) into the lateral ventricle did not change the renal vasodilation produced by moxonidine (20 nmol) into the lateral ventricle. The alpha1-adrenoceptor antagonist prazosin (320 nmol) injected into the 4th ventricle did not affect the cardiovascular effects of moxonidine. However, prazosin (80, 160 and 320 nmol) into the lateral ventricle abolished the renal vasodilation (-17+/-4, -6+/-9 and 2+/-11%) produced by moxonidine. The results indicate that the decrease in renal vascular

  12. Rock slope response to fluvial incision in the central Swiss Alps

    Science.gov (United States)

    Leith, Kerry; Fox, Matthew; Moore, Jeffrey R.

    2016-04-01

    The longitudinal profile of rivers intersecting the Rhone Valley in the central Swiss Alps suggests the development of topography throughout much of this region has been dominated by interglacial fluvial incision and ongoing tectonic uplift with only minimal glacial erosion since the mid-Pleistocene transition. Evidence indicates bedrock river incision during this period reflects a base level fall of between 500 m and 800 m (depending on the degree of overdeepening following an early period of enhanced glacial incision). This observation raises important questions regarding the preservation, or development of hillslope morphologies through multiple glacial-interglacial cycles. Since the pioneering works of Richter (1900) and Penck and Brückner (1909), Alpine geomorphologists have commented on a sequence of between three and five moderately dipping matched terraces that converge toward inferred paleo-river channels up to 800 m above the axis of many valleys. Here, we use a combination of integral analysis, forward streampower models, and a new method of topographic analysis based on high resolution LiDAR DEMs in order to test the correspondence of valley morphologies in this formerly glaciated landscape, with hillslope processes initiated by fluvial incision up to 700,000 years ago. Results indicate topography adjacent to reaches subjected to transient fluvial incision is characterized by a coherent region of consistently steep slopes, while narrow gorges correspond to rapid incision close to the Rhone valley since MIS 5. A majority of hillslopes converge to our initial fluvial valley floor, or the location of propagating knickpoints. The correspondence between intermediate-level terraces and modeled stages of river incision is, however, currently unclear. These results offer a unique insight into the long-term response of bedrock slopes to varying rates of base level fall, and the cumulative impact of glacial erosion on Alpine valley walls since MIS 11. Penck, A

  13. Responses of the central nervous system to high linear energy transfer radiation: NSCOR project highlights

    Science.gov (United States)

    Nelson, Gregory; Fike, John; Limoli, Charles; Obenaus, André; Raber, Jacob; Soltesz, Ivan; Vlkolinský, Roman

    2014-01-01

    Overview: The five-university NSCOR project investigates the responses of the central nervous system to space-like charged particle exposure by evaluating: synaptic function, in vitro and in vivo neurogenesis, behavior and behaviorally induced gene expression, and oxidative stress of the mouse hippocampus and cultured neural precursor cells. To test the role of reactive oxygen species in mediating the effects of radiation exposure, we compare responses in a catalase overexpressing transgenic mouse strain to wild type. We also use computational models of the hippocampus in three dimensions, informed by experimental measurements, to provide insight into network behavior. Radiation exposure protocols include single, acute whole-body exposures to 1H, 28Si and 56Fe ions and mixed field exposures using 1H + 56Fe ions (24 h later). The animal models are 10-week-old C57BL/6J and MCATtg males which are evaluated at 30 and 90 days postirradiation. In vitro models are cultured murine and human neural stem cells irradiated with 1H, 16O, 28Si and 56Fe ions at multiple energies and are evaluated at times from days to weeks. Highlights: Neural stem cells organized into neurospheres were irradiated with several ions at doses as low as 0.75 cGy. Data show that significant oxidative stress occurs that alters survival, proliferation and differentiation. Overall trends indicate that changes in oxidative stress (persisting for weeks) correlate with particle linear energy transfer (LET). 56Fe ions elicited the largest and most persistent changes in stress markers, including antioxidant enzyme expression levels. The hippocampus-dependent contextual fear conditioning (CFC) and novel object recognition (NOR) paradigms were used to assess cognition and showed cognitive deficits after irradiation with the NOR paradigm more sensitive than CFC. Analysis of neurogenesis indicates that overall neurogenesis is inhibited at doses ≥1 Gy, but newly born activated microglia are significantly

  14. Actual measurement, hygrothermal response experiment and growth prediction analysis of microbial contamination of central air conditioning system in Dalian, China.

    Science.gov (United States)

    Lv, Yang; Hu, Guangyao; Wang, Chunyang; Yuan, Wenjie; Wei, Shanshan; Gao, Jiaoqi; Wang, Boyuan; Song, Fangchao

    2017-04-03

    The microbial contamination of central air conditioning system is one of the important factors that affect the indoor air quality. Actual measurement and analysis were carried out on microbial contamination in central air conditioning system at a venue in Dalian, China. Illumina miseq method was used and three fungal samples of two units were analysed by high throughput sequencing. Results showed that the predominant fungus in air conditioning unit A and B were Candida spp. and Cladosporium spp., and two fungus were further used in the hygrothermal response experiment. Based on the data of Cladosporium in hygrothermal response experiment, this paper used the logistic equation and the Gompertz equation to fit the growth predictive model of Cladosporium genera in different temperature and relative humidity conditions, and the square root model was fitted based on the two environmental factors. In addition, the models were carried on the analysis to verify the accuracy and feasibility of the established model equation.

  15. Meta-analysis of placebo responses in central neuropathic pain: impact of subject, study, and pain characteristics.

    Science.gov (United States)

    Cragg, Jacquelyn J; Warner, Freda M; Finnerup, Nanna Brix; Jensen, Mark P; Mercier, Catherine; Richards, John Scott; Wrigley, Paul; Soler, Dolors; Kramer, John L K

    2016-03-01

    The placebo response is a complex construct related to psychobiological effects, as well as natural history and regression to the mean. Moreover, patient and study design characteristics have also been proposed as significantly affecting placebo responses. The aim of the current investigation was to identify factors that contribute to variable placebo responses in clinical trials involving individuals with central neuropathic pain. To this end, we performed a systematic review and meta-analysis of placebo-controlled trials examining pharmacological and noninvasive brain stimulation interventions for central neuropathic pain. Study design, subject characteristics, and pain ratings for the placebo group were extracted from each trial. Pooling of results and identification of moderating factors were carried out using random effects meta-analysis and meta-regression techniques. A total of 39 published trials met the inclusion criteria (spinal cord injury, n = 26; stroke, n = 6; multiple sclerosis, n = 7). No significant publication bias was detected. Overall, there was a significant effect for placebo to reduce central pain (-0.64, CI: -0.83 to -0.45). Smaller placebo responses were associated with crossover-design studies, longer pain duration, and greater between-subject baseline pain variability. There were no significant effects for neurological condition (stroke vs multiple sclerosis vs spinal cord injury) or the type of intervention (eg, pharmacological vs noninvasive brain stimulation). In a planned subanalysis, the severity of damage in the spinal cord also had no significant effect on the placebo response. Further study is warranted to identify factors that may explain the impact of pain duration on the placebo response at the individual subject level.

  16. Carbon stock and its responses to climate change in Central Asia.

    Science.gov (United States)

    Li, Chaofan; Zhang, Chi; Luo, Geping; Chen, Xi; Maisupova, Bagila; Madaminov, Abdullo A; Han, Qifei; Djenbaev, Bekmamat M

    2015-05-01

    Central Asia has a land area of 5.6 × 10(6) km(2) and contains 80-90% of the world's temperate deserts. Yet it is one of the least characterized areas in the estimation of the global carbon (C) stock/balance. This study assessed the sizes and spatiotemporal patterns of C pools in Central Asia using both inventory (based on 353 biomass and 284 soil samples) and process-based modeling approaches. The results showed that the C stock in Central Asia was 31.34-34.16 Pg in the top 1-m soil with another 10.42-11.43 Pg stored in deep soil (1-3 m) of the temperate deserts. They amounted to 18-24% of the global C stock in deserts and dry shrublands. The C stock was comparable to that of the neighboring regions in Eurasia or major drylands around the world (e.g. Australia). However, 90% of Central Asia C pool was stored in soil, and the fraction was much higher than in other regions. Compared to hot deserts of the world, the temperate deserts in Central Asia had relatively high soil organic carbon density. The C stock in Central Asia is under threat from dramatic climate change. During a decadal drought between 1998 and 2008, which was possibly related to protracted La Niña episodes, the dryland lost approximately 0.46 Pg C from 1979 to 2011. The largest C losses were found in northern Kazakhstan, where annual precipitation declined at a rate of 90 mm decade(-1) . The regional C dynamics were mainly determined by changes in the vegetation C pool, and the SOC pool was stable due to the balance between reduced plant-derived C influx and inhibited respiration.

  17. Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress.

    Science.gov (United States)

    Wulsin, Aynara C; Herman, James P; Solomon, Matia B

    2010-08-01

    Glucocorticoid dyshomeostasis is observed in a proportion of depressed individuals. As a result, glucocorticoid receptor (GR) antagonists are currently being tested as potential anti-depressants. The current study was designed to test the efficacy of mifepristone, a GR antagonist, in mitigating behavioral, neuroendocrine and central nervous system (CNS) responses to an acute stressor. Adult male rats were treated for 5 days with mifepristone (10 mg/kg) and then exposed to the forced swim test (FST). Treatment with mifepristone decreased immobility and increased swimming (but not climbing) behavior in the FST, consistent with anti-depressant action. In addition, mifepristone dampened the ACTH response to FST exposure. In the CNS, mifepristone increased c-Fos expression in all subdivisions of the medial prefrontal cortex (mPFC) and decreased neuronal activity in some subdivisions of the hippocampus including the CA2, CA3, and hilus region of the dentate gyrus in animals exposed to FST. In contrast, mifepristone increased neuronal activity in the ventral subiculum (output region of the hippocampus) and decreased c-Fos expression in the central amygdala (CeA) in animals exposed to FST. These data suggest that anti-depressant efficacy and perhaps HPA dampening properties of RU486 are related to alterations in key limbic circuits mediating CNS stress responses, resulting in enhanced stress inhibition (via the mPFC and ventral subiculum) as well as decreased stress excitation (central amygdala). Overall the data suggest that drugs targeting the glucocorticoid receptor may ameliorate stress dysfunction associated with depressive illness.

  18. Central Svalbard 2000-2011 meteorological dynamics and periglacial landscape response

    DEFF Research Database (Denmark)

    Christiansen, Hanne Hvidtfeldt; Humlum, O.; Eckerstorfer, M.

    2013-01-01

    Local mountain meteorology of the landscape around Longyearbyen in central Svalbard is analyzed through the decade from 2000 to 2011. Standard meteorological stations from close to sea level and up to 464 m a.s.1. located on different periglacial landforms, have been used. During winters with lit...

  19. Central Cardiovascular Responses of Quadriplegic Subjects to Arm Exercise at Varying Levels of Oxygen Uptake.

    Science.gov (United States)

    Figoni, Stephen F.

    The purpose of this study was to assess selected central cardiovascular functions of spinal cord injured, quadriplegic subjects at varying levels of oxygen uptake (VO sub 2). Subjects included 11 untrained, male college students with C5, C6, or C7 complete quadriplegia and 11 able-bodied reference subjects. Exercise was performed on a Monark cycle…

  20. Behavioral responses of gorillas to habituation in the Dzanga-Ndoki National Park, Central African Republic

    NARCIS (Netherlands)

    Blom, A.; Cipolletta, C.; Brunsting, A.M.H.; Prins, H.H.T.

    2004-01-01

    We monitored the impact of habituation for tourism through changes in gorillas' behavior during the habituation process at Bai Hokou (Dzanga-Ndoki National Park, Central African Republic) from August 1996 to December 1999. From August 1998 onwards we focused on one gorilla group: the Munye. During t

  1. Study on Litterfall, Nutrient Returned by Litterfall and Nutrient Use Efficiency in Scenic Forests of Central Japan%日本中部风景林凋落物量、养分归还量

    Institute of Scientific and Technical Information of China (English)

    薛达; 薛立; 罗山

    2001-01-01

    研究了日本中部的3个风景林——常绿针叶林、常绿阔叶林和常绿落叶阔叶混交林的凋落物,养分归还量和养分利用效率.常绿针叶林、常绿阔叶林和常绿落叶阔叶混交林的年凋落量分别为7562、6023和5565kg/hm2,养分年归还量分别为233.87、125.20和140.23kg/hm2.各养分中N、K和Ca的归还量大于P和Mg.叶的养分归还量占养分年归还量的64.19%~79.29%.常绿针叶林和常绿阔叶林中Mg的利用效率高,表明Mg可能是这2种风景林生长的限制因子.%Litterfall amounts, nutrients returned by litterfall and nutrientuse efficiency in evergreen coniferous forest, evergreen broad-leaved forest, and evergreen and deciduous broad-leaved mixed forest of Central Japan were studied. Annual amounts of litterfall in evergreen coniferous forest, evergreen broad-leaved forest, and mixed forest were 7 562, 6 023 and 5 565 kg/hm2, respectively, which resulted in the amount of nutrient contained in litterfall being 233.87, 125.20 and 140.23 kg/hm2, respectively. Returned amounts of N, K and Ca were greater than P and Mg in all scenic forests, and leaves contributed 64.19%~79.29% of the total. A high Mg use efficiency in evergreen coniferous forest and evergreen broad-leaved forest indicates that Mg may be in a limited supply in the two scenic forests.

  2. GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord.

    Science.gov (United States)

    Corns, Laura F; Deuchars, Jim; Deuchars, Susan A

    2013-10-11

    The area surrounding the central canal of the postnatal mammalian spinal cord is a highly plastic region that exhibits many similarities to other postnatal neurogenic niches, such as the subventricular zone. Within this region, ependymal cells have been identified as neural stem cells however very little is known about their properties and how the local environment, including neurotransmitters, is capable of affecting them. The neurotransmitter GABA is present around the central canal and is known to affect cells within other postnatal neurogenic niches. This study used whole cell patch clamp electrophysiology and intracellular dye-loading in in vitro Wistar rat spinal cord slices to characterise ependymal cells and their ability to respond to GABA. Ependymal cells were defined by their passive response properties and low input resistances. Extensive dye-coupling was observed between ependymal cells; this was confirmed as gap junction coupling using the gap junction blocker, 18β-glycyrrhetinic acid, which significantly increased the input resistance of ependymal cells. GABA depolarised all ependymal cells tested; the partial antagonism of this response by bicuculline and gabazine indicates that GABA(A) receptors contribute to this response. A lack of effect by baclofen suggests that GABA(B) receptors do not contribute to the GABAergic response. The ability of ependymal cells to respond to GABA suggests that GABA could be capable of influencing the proliferation and differentiation of cells within the neurogenic niche of the postnatal spinal cord.

  3. The influence of asymmetry in centralizing spring of squeeze film damper on stability and bifurcation of rigid rotor response

    Directory of Open Access Journals (Sweden)

    Hamidreza Heidari

    2016-12-01

    Full Text Available One of the main challenges in the design of rotating machinery is the occurrence of undesirable vibration. In this paper, stability and bifurcation of the unbalance response of a rigid rotor supported by squeeze film damper with asymmetry in centralizing spring are investigated. The unbalanced rotor response is determined by the shooting method and the stability of these solutions is examined by using the Floquet theorem. Numerical examples are given for both symmetric (Kx=Ky and asymmetry (Kx≠Ky centralizing springs in x or y direction. Jump phenomenon and subharmonic and quasi-periodic vibrations are predicted for a range of design and operating parameters such as the unbalancing (U, gravity (W, bearing (B and spring (K. The results show that increasing the spring stiffness asymmetry parameter in y direction has no influence on the nature of system response and occurrence of bifurcation. But, examining the effect of increase in stiffness parameter in x direction leads to occurrence instability and period-doubling bifurcation in response to the system. Our findings show that this phenomena are due to the weight force in the y direction. Finally, it is shown that the unsymmetrical stiffness of squeeze film dampers in the presence of cavitation promoting the chance of undesirable nonsynchronous vibrations.

  4. Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.

    Directory of Open Access Journals (Sweden)

    Narisara Chantratita

    . pseudomallei lipopolysaccharide in blood is greater than the response to other lipopolysaccharide expressing isolates. Our findings suggest that B. pseudomallei lipopolysaccharide may play a central role in stimulating the host response in melioidosis.

  5. Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

    Directory of Open Access Journals (Sweden)

    N. Isbil-Buyukcoskun

    2001-06-01

    Full Text Available In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv choline (50, 100 and 150 µg on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 µg, icv, an angiotensin-converting enzyme inhibitor, captopril (25 and 50 µg, icv, was administered 3 min before choline. Twenty-five µg captopril did not block the pressor effect of choline, while 50 µg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.

  6. Understanding coupled climatic and ecosystem responses to global climate change in the Central Grasslands

    Energy Technology Data Exchange (ETDEWEB)

    Falkner, M.B.; Detling, J.; Ojima, D.; Pielke, R.A.; Stohlgren, T.J. (Colorado State Univ., Ft. Collins (United States)); Kittel, T.G.F. (Colorado State Univ., Ft. Collins (United States) UCAR, Boulder, CO (United States)); Lenihan, J.; Neilson, R. (Oregon State Univ., Corvallis (United States)); Reiners, W. (Univ. of Wyoming, Laramie (United States))

    1993-06-01

    A long-term National Park Service research program to assess the potential effect of global climate change on the Central Grasslands Biogeographic Area is underway. The program consists of two integrated projects: Projecting climate and vegetation change at regional to landscape scales; and Predicting the effect of global change on vegetation in park landscapes at the plot to landscape scales. Together, these integrated field and modeling studies establish a means to validate mesoscale and landscape vegetation models, a central goal of the NPS Global Change Research Program. Vegetation life form modeling suggests that under climate change scenarios the distribution of grassland vegetation zones will undergo major shifts. Results indicate that climate change impacts that reduce water availability will more severely depress productivity of C[sub 3] grass communities relative to C[sub 4] grass communities.

  7. Epidemiology of diabetes mellitus in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Blackard, W.G.; Omori, Yoshiaki; Freedman, L.R.

    1964-03-12

    The clinical and epidemiological features of diabetes mellitus in Japan have been compiled and compared with data from other countries. Diabetes is basically the same in Japan as elsewhere: however, consideration of important differences has led to the following conclusions: The rarity of ketoacidosis in Japan is due to the mild carbohydrate defect present in most diabetics. The mild carbohydrate intolerance in diabetics is probably in part due to a high carbohydrate intake. Diabetic retinopathy is more common in women than in men in Japan; there are limited and conflicting data from the West on this point, but retinopathy, nephropathy and neuropathy occur about as frequently in Japan as in the West. Because of marked dietary differences between Japan and Western countries, these findings suggest that dietary fat has no significance in the pathogenesis of these lesions. Peripheral gangrene is distinctly unusual in Japanese diabetics. This suggests that either: the responsible vascular lesions are different from those responsible for nephropathy and retinopathy; or that small vessel lesions are the same but the lack of large vessel atherosclerosis in the population accounts for the decreased incidence of gangrene. Men have diabetes 2 or 3 times as commonly as women in Japan. If sex-limited inheritance is discarded as a possible reason, it is likely that adult-onset diabetes is more common in men than women except in those countries (the West) where women gain relatively large amounts of weight. The rarity of juvenile diabetes in Japan is best explained by the infrequency of responsible genetic factors. As a consequence, it is likely that juvenile diabetes is caused by different or additional genetic factors which are not significant in adult-onset diabetes. Diabetes prevalance varies sufficiently between different localities in the same country to render the concept of national prevalance of doubtful usefulness. 55 references, 3 figures, 3 tables.

  8. Hydrological response of the central Pyrenees to projected environmental change in the 21st century

    OpenAIRE

    López-Moreno, J. I.; S. M. Vicente-Serrano; J. Zabalza; J. Revuelto; Gilaberte, M.; Azorín-Molina, C.; Morán-Tejeda, E.; García-Ruiz, J. M.; Tague, C

    2014-01-01

    Streamflows in five Mediterranean mountain headwaters in the central Spanish Pyrenees were projected under various climate and land use change scenarios. Streamflows were simulated using the Regional Hydro-Ecologic Simulation System (RHESSys). The results show that changes in precipitation and temperature could cause a decline of annual streamflow between 13% and 23%, depending on the considered catchment. When the effect of increased forest cover in the basins is added to climate change effe...

  9. Accuracy of System Step Response Roll Magnitude Estimation from Central and Peripheral Visual Displays and Simulator Cockpit Motion

    Science.gov (United States)

    Hosman, R. J. A. W.; Vandervaart, J. C.

    1984-01-01

    An experiment to investigate visual roll attitude and roll rate perception is described. The experiment was also designed to assess the improvements of perception due to cockpit motion. After the onset of the motion, subjects were to make accurate and quick estimates of the final magnitude of the roll angle step response by pressing the appropriate button of a keyboard device. The differing time-histories of roll angle, roll rate and roll acceleration caused by a step response stimulate the different perception processes related the central visual field, peripheral visual field and vestibular organs in different, yet exactly known ways. Experiments with either of the visual displays or cockpit motion and some combinations of these were run to asses the roles of the different perception processes. Results show that the differences in response time are much more pronounced than the differences in perception accuracy.

  10. Central and peripheral psychophysiological responses to trauma-related cues in subclinical posttraumatic stress disorder: a pilot study.

    Science.gov (United States)

    Wessa, Michèle; Karl, Anke; Flor, Herta

    2005-11-01

    This study examined verbal-subjective, peripheral and central physiological responses of motor vehicle accident (MVA) survivors with subclinical posttraumatic stress disorder (PTSD), without PTSD symptoms as well as healthy controls. Seven persons of each group were exposed to positive, neutral, accident-related and negative, non-accident-related slides. The verbal-subjective ratings of the slides did not differ between the groups. In contrast to the verbal ratings of the trauma-related materials, the behavioral and physiological responses showed a remarkable dissociation from these reports. The startle responses were enhanced to accident-related slides only in the PTSD group and MVA survivors with PTSD had a significantly lower response to the neutral slides than MVA survivors without PTSD. P200 was lower to positive, neutral and negative slides in the PTSD group compared to both other groups. The late positive complex showed no group-related effects. The data suggest that traumatized persons with PTSD show exaggerated emotional responses to trauma-related stimuli and reduced cognitive responses to several types of stimuli that may interfere with the extinction of the emotional trauma memory.

  11. Mesenteric artery response to head-up tilt-induced central hypovolaemia and hypotension

    DEFF Research Database (Denmark)

    Perko, M J; Madsen, P; Perko, Grazyna

    1997-01-01

    .01) and an increase in thoracic electric impedance from 38.6 +/- 2.1 to 42.6 +/- 2.1 omega (P 6 mmHg: P ...Superior mesenteric artery (SMA) blood flow and impedance were evaluated by duplex ultrasound during head-up tilt (HUT)-induced central hypovolaemia and hypotension in eight healthy volunteers. HUT induced a reduction in cardiac stroke volume from 88.8 +/- 6.3 to 64.7 +/- 6.3 ml (mean +/- SEM; P

  12. Japan reforms its nuclear safety

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2013-11-15

    The Fukushima Daiichi NPP accident deeply questioned the bases of nuclear safety and nuclear safety regulation in Japan. It also resulted in a considerable loss of public confidence in the safety of nuclear power across the world. Although the accident was caused by natural phenomena, institutional and human factors also largely contributed to its devastating consequences, as shown by the Japanese Diet's and Government's investigation reports. 'Both regulators and licensees were held responsible and decided to fully reconsider the existing approaches to nuclear safety. Consequently, the regulatory system underwent extensive reform based on the lessons learned from the accident,' Yoshihiro Nakagome, the President of Japan Nuclear Energy Safety Organisation, an ETSON member TSO, explains. (orig.)

  13. Neutrophils that infiltrate the central nervous system regulate T cell responses

    DEFF Research Database (Denmark)

    Zehntner, Simone P; Brickman, Cristina; Bourbonnière, Lyne;

    2005-01-01

    Regulation of inflammatory responses is critical to progression of organ-specific autoimmune disease. Although many candidate cell types have been identified, immunoregulatory activity has rarely been directly assayed and never from the CNS. We have analyzed the regulatory capability of Gr-1high......, and activated Gr-1high neutrophils within the target organ determines the outcome of inflammatory and potentially autoimmune T cell responses....

  14. Lessons From Japan

    Institute of Scientific and Technical Information of China (English)

    LI YAFEN

    2010-01-01

    @@ In the mid-to late 1980s, Japan experienced a prolonged bubble economy and entered a decadelong recession after it burst. The economy in China currently has several things in common with Japan's economy before its bubbles burst, such as a large foreign exchange reserve, an international dispute over currency revaluation, excess liquidity, and soaring asset prices.

  15. Restored agricultural wetlands in Central Iowa: habitat quality and amphibian response

    Science.gov (United States)

    Pierce, Clay; Rebecca A. Reeves,; Smalling, Kelly; Klaver, Robert W.; Vandever, Mark; Battaglin, William A.; Muths, Erin L.

    2016-01-01

    Amphibians are declining throughout the United States and worldwide due, partly, to habitat loss. Conservation practices on the landscape restore wetlands to denitrify tile drainage effluent and restore ecosystem services. Understanding how water quality, hydroperiod, predation, and disease affect amphibians in restored wetlands is central to maintaining healthy amphibian populations in the region. We examined the quality of amphibian habitat in restored wetlands relative to reference wetlands by comparing species richness, developmental stress, and adult leopard frog (Lithobates pipiens) survival probabilities to a suite of environmental metrics. Although measured habitat variables differed between restored and reference wetlands, differences appeared to have sub-lethal rather than lethal effects on resident amphibian populations. There were few differences in amphibian species richness and no difference in estimated survival probabilities between wetland types. Restored wetlands had more nitrate and alkaline pH, longer hydroperiods, and were deeper, whereas reference wetlands had more amphibian chytrid fungus zoospores in water samples and resident amphibians exhibited increased developmental stress. Restored and reference wetlands are both important components of the landscape in central Iowa and maintaining a complex of fish-free wetlands with a variety of hydroperiods will likely contribute to the persistence of amphibians in this landscape.

  16. Lightning activity on the central Tibetan Plateau and its response to convective available potential energy

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Lightning flash activities on the central Tibetan Plateau have been studied by using the satellite-based Lightning Imaging Sensor (LIS) database from January 1998 to July 2002. The lightning activity shows a clear diurnal variation on the central Plateau. The peak lightning activity appears at about 17︰00 which is 3 h earlier than that in Jingzhou, Hubei in the same latitude belt nearby, indicating that the lightning activity is a sensitive indicator of solar heating on the Plateau. The lightning discharge is weaker on the Plateau than Jingzhou, Hubei and other low-altitude continental regions because of the lower convective available potential energy (CAPE) on the Plateau. The CAPE on the Plateau is 12 times lower than that in Jingzhou, Hubei, and 20 times lower than that in the sea-level region, such as Guangzhou and Florida. However, the sensitivity of lightning activity to CAPE changes on the Plateau is up to 30 times more sensitive than other prominent low-altitude regions.

  17. Responses of Aquatic Saproxylic Macroinvertebrates to Reduced-Impact Logging in Central Amazonia.

    Science.gov (United States)

    Roque, F O; Escarpinati, S C; Valente-Neto, F; Hamada, N

    2015-08-01

    Reduced-impact logging (RIL) is an alternative land use because it reduces damage to forest cover in comparison with clear-cut practices. However, management practices adopted in RIL can affect wood availability and, consequently, fauna associated with dead wood during part of their life cycle (saproxylic). In this study, we evaluated whether aquatic saproxylic macroinvertebrates are affected by reduced-impact logging in Central Amazonia. We selected six streams in areas under reduced-impacted logging and six in primary forest areas and collected submerged woody debris. We did not find any differences in water pH, conductivity, and wood availability between reduced-impacted forest and primary forest streams. We found 248 saproxylic aquatic macroinvertebrates belonging to 37 taxa. We found five wood specialist (Dryops, Lutrochus, Stenochironomus, Oukuriella, and Endotribelos) and 32 generalists, totalling 98 and 150 individuals, respectively. In general, our results show that reduced-impact logging does not affect richness, abundance, and composition of saproxylic macroinvertebrates. The main explanation for this pattern is that management practices do not change important macroinvertebrate niche dimensions, including wood availability and the water's chemical and physical variables. Thus, controlled logging, such as applied in the area of the Central Amazonian streams studied, opens a new prospect for insect conservation and commercial exploitation of wood, which is not possible when clear-cut practices are adopted.

  18. SARM is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection

    OpenAIRE

    Hou, Ying-Ju; Banerjee, Rebecca; Thomas, Bobby; Nathan, Carl; García-Sastre, Adolfo; Ding, Aihao; Uccellini, Melissa B.

    2013-01-01

    Four of the five members of the Toll-interleukin-1 receptor (TIR) domain-containing adaptor family are required for signaling downstream of Toll-like receptors, promoting innate immune responses against different pathogens. However, the role of the fifth member of this family, sterile alpha and TIR-domain containing 1 (SARM), is unclear. SARM is expressed primarily in the central nervous system where it is required for axonal death. Studies in C.elegans have also shown a role for SARM in inna...

  19. U.S./Japan burdensharing: constraints to increased Japanese contribution

    OpenAIRE

    Braker, Patrick J.

    1990-01-01

    Approved for public release; distribution is unlimited. This thesis explores issues relevant to U.S./Japan burdensharing. As U.S. defense expenditures are reduced in the 1990's, U.S. allies will be called upon to contribute a greater share to meet common security responsibilities. Japan's government faces a multitude of constraints to increasing defense expenditures placed upon them by the U.S., the Japanese public and Japan's Asian neighbors. Some of these constraints are affected sig...

  20. Central serotonin transporter levels are associated with stress hormone response and anxiety

    Science.gov (United States)

    Reimold, Matthias; Knobel, Astrid; Rapp, Michael A.; Batra, Anil; Wiedemann, Klaus; Ströhle, Andreas; Zimmer, Anke; Schönknecht, Peter; Smolka, Michael N.; Weinberger, Daniel R.; Goldman, David; Machulla, Hans-Jürgen; Bares, Roland; Heinz, Andreas

    2010-01-01

    Rationale Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients suffering from negative mood states. Objective The objective of this cross-sectional study was to assess the interrelation of cortisol response, thalamic 5-HTT levels, and anxiety in healthy subjects and two previously published samples of patients with unipolar major depression (UMD) and obsessive–compulsive disorder (OCD), controlling for age, gender, 5-HTT genotype, smoking, and seasonality. Methods Regional 5-HTT levels and cortisol response to dexamethasone-corticotropin (Dex-CRH) challenge were assessed in consecutive samples of medication-free patients suffering from UMD (N=10) and OCD (N=10), and 20 healthy volunteers. The intervention used was combined Dex-CRH test and [11C]DASB positron emission tomography. The main outcome measures were: 5-HTT binding potential (BPND) in a predefined thalamic ROI, cortisol response defined as the maximum cortisol increase in the combined Dex-CRH-test, and state of anxiety from the state-trait-anxiety inventory. Results Reduced thalamic 5-HTT BPND was associated with increased cortisol response (r=−0.35, p<0.05; in patients: r=−0.53, p<0.01) and with increased state anxiety (r=−0.46, p<0.01), surviving correction for age, gender, 5-HTT genotype, smoking, and seasonality (p<0.05). The 5-HTT genotype, on the contrary, was not significantly associated with cortisol response (p=0.19) or negative mood (p=0.23). Conclusion The association between stress hormone response, thalamic 5-HTT levels, and anxiety in patients suffering from negative mood states suggests an interaction between two major mechanisms implicated in negative mood states in humans. PMID:20585760

  1. Optimization of Jiawei Qing'e Oral Fast Disintegrating Tablets Based on Response Surface-Central Composite Design

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wei-ling; WANG Ya-jing; GAO Xiu-mei; GAO Xu; PENG Shu-juan; ZHENG Yin; OKEKE Chukwunweike Ikechukwu

    2013-01-01

    Objective To apply the response surface-central composite design to developing and optimizing the oral fast disintegrating tablets (ODT) formulation for Jiawei Qing'e,a kind of prescription of Chinese herbal medicine.Methods The bitterness of Jiawei Qing'e was masked using Eudragit E-100 by solvent evaporation technique.Response surface approach was applied to investigating the interaction of formulation parameters in optimizing the formulation.The independent variables were Eudragit E-100/drug ratio (X1),amount of disintegrants (X2),and the amount of diluents (X3).The disintegration time (Y1),hardness (Y2),and weight variations of the tablets were characterized.Results The models predicted levels ofX1 =4.63%,X2 =5.25%,and X3 =34.33%,for the optimal formulation having a hardness of 3.0 kg with the disintegration time of 30 s within experimental region.The observed response of Y1 =26.5 s and Y2 =3.14 kg reasonably agreed with the predicted response.Conclusion Response surface methodology shows the good predictability and reliability in optimizing the formulation.The optimized ODT of Jiawei Qing'e has acceptable taste,rapid disintegrating ability,and good mechanical strength.

  2. Mesenteric artery response to head-up tilt-induced central hypovolaemia and hypotension

    DEFF Research Database (Denmark)

    Perko, M J; Madsen, P; Perko, Grazyna

    1997-01-01

    Superior mesenteric artery (SMA) blood flow and impedance were evaluated by duplex ultrasound during head-up tilt (HUT)-induced central hypovolaemia and hypotension in eight healthy volunteers. HUT induced a reduction in cardiac stroke volume from 88.8 +/- 6.3 to 64.7 +/- 6.3 ml (mean +/- SEM; P ... the normotensive and the hypotensive phase of HUT, the SMA diameter (5.7 +/- 0.03 mm) and blood flow (514 +/- 75 ml min-1) did not change significantly, although the end-diastolic velocity increased from 9.7 +/- 4.8 to 39.7 +/- 4.0 cm s-1 (P ... or reduced arterial pressure, supports a reduction in the SMA impedance as it was reproduced during a meal test when a moderate reduction in mean arterial pressure (87 +/- 4 to 80 +/- 4 mm Hg; P = 0.04) was accompanied by a ninefold increase in the end-diastolic velocity (P

  3. Response of Central European Civil Security Systems to the Economic Crisis

    Directory of Open Access Journals (Sweden)

    Brázová Věra - Karin

    2015-12-01

    Full Text Available The public sector across Europe and elsewhere was affected by the economic crisis which fully unfolded in 2008. Considerable attention has been paid in the literature to the impacts of related budgetary cuts on social welfare, while some other areas remain largely under-researched. One of such areas is the so-called civil security, where no such endeavour has been attempted so far. In order to fill this gap, the paper examines the civil security systems of Central European countries (Czech Republic, Slovakia, Poland and Hungary, employing a qualitative comparative analysis. Taking on the systems perspective, the article inquires how the stress posed by the economic crisis affected the civil security systems - their structure and financing. The paper builds on the findings from a 7th FP project, “ANVIL”, within which data on civil protection and disaster management systems were collected.

  4. Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system

    DEFF Research Database (Denmark)

    Banati, M; Csecsei, P; Koszegi, E

    2013-01-01

    BACKGROUND: Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity. METHODS: Antibodies against gliadin, tissue transglutaminase (t......TG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis...

  5. Long-Term Response of Groundwater Nitrate Concentrations to Management Regulations in Nebraska's Central Platte Valley

    Directory of Open Access Journals (Sweden)

    Mary E. Exner

    2010-01-01

    Full Text Available The impact of 16 years (1988–2003 of management practices on high groundwater nitrate concentrations in Nebraska's central Platte River valley was assessed in a 58,812-ha (145,215-ac groundwater quality management area intensively cropped to irrigated corn (Zea mays L.. Crop production and groundwater nitrate data were obtained from ~23,800 producer reports. The terrace, comprising ~56% of the study area, is much more intensively cropped to irrigated corn than the bottomland. From 1987 to 2003, average groundwater nitrate concentrations in the primary aquifer beneath the bottomland remained static at ~8 mg N/l. During the same period, average groundwater nitrate concentrations in the primary aquifer beneath the terrace decreased from 26.4 to 22.0 mg N/l at a slow, but significant (p < 0.0001, rate of 0.26 mg N/l/year. Approximately 20% of the decrease in nitrate concentrations can be attributed to increases in the amount of N removed from fields as a consequence of small annual increases in yield. During the study, producers converted ~15% of the ~28,300 furrow-irrigated terrace hectares (~69,800 ac to sprinkler irrigation. The conversion is associated with about an additional 50% of the decline in the nitrate concentration, and demonstrates the importance of both improved water and N management. Average N fertilizer application rates on the terrace were essentially unchanged during the study. The data indicate that groundwater nitrate concentrations have responded to improved management practices instituted by the Central Platte Natural Resources District.

  6. Marine response to climate changes during the last five millennia in the central Mediterranean Sea

    Science.gov (United States)

    Margaritelli, G.; Vallefuoco, M.; Di Rita, F.; Capotondi, L.; Bellucci, L. G.; Insinga, D. D.; Petrosino, P.; Bonomo, S.; Cacho, I.; Cascella, A.; Ferraro, L.; Florindo, F.; Lubritto, C.; Lurcock, P. C.; Magri, D.; Pelosi, N.; Rettori, R.; Lirer, F.

    2016-07-01

    We present a high-resolution paleoclimatic and paleoenvironmental reconstruction of the last five millennia from a shallow water marine sedimentary record from the central Tyrrhenian Sea (Gulf of Gaeta) using planktonic foraminifera, pollen, oxygen stable isotope, tephrostratigrapy and magnetostratigrapy. This multiproxy approach allows to evidence and characterize nine time intervals associated with archaeological/cultural periods: Eneolithic (base of the core-ca. 2410 BCE), Early Bronze Age (ca. 2410 BCE-ca. 1900 BCE), Middle Bronze Age-Iron Age (ca. 1900 BCE-ca. 500 BCE), Roman Period (ca. 500 BCE-ca. 550 CE), Dark Age (ca. 550 CE-ca. 860 CE), Medieval Climate Anomaly (ca. 860 CE-ca. 1250 CE), Little Ice Age (ca. 1250 CE-ca. 1850 CE), Industrial Period (ca. 1850 CE-ca. 1950 CE), Modern Warm Period (ca. 1950 CE-present day). The reconstructed climatic evolution in the investigated sedimentary succession is coherent with the short-term climate variability documented at the Mediterranean scale. By integrating the planktonic foraminiferal turnover from carnivorous to herbivorous-opportunistic species, the oxygen isotope record and the pollen distribution, we document important modification from the onset of the Roman Period to the present-day. From ca. 500 CE upwards the documentation of the cooling trend punctuated by climate variability at secular scale evidenced by the short-term δ18O is very detailed. We hypothesise that the present day warm conditions started from the end of cold Maunder event. Additionally, we provide that the North Atlantic Oscillation (NAO) directly affected the central Mediterranean region during the investigated time interval.

  7. Comparative study of two active faults in different stages of the earthquake cycle in central Japan -The Atera fault (with 1586 Tensho earthquake) and the Nojima fault (with 1995 Kobe earthquake)-

    Science.gov (United States)

    Matsuda, T.; Omura, K.; Ikeda, R.

    2003-12-01

    National Research Institute for Earth Science and Disaster Prevention (NIED) has been conducting _gFault zone drilling_h. Fault zone drilling is especially important in understanding the structure, composition, and physical properties of an active fault. In the Chubu district of central Japan, large active faults such as the Atotsugawa (with 1858 Hietsu earthquake) and the Atera (with 1586 Tensho earthquake) faults exist. After the occurrence of the 1995 Kobe earthquake, it has been widely recognized that direct measurements in fault zones by drilling. This time, we describe about the Atera fault and the Nojima fault. Because, these two faults are similar in geological situation (mostly composed of granitic rocks), so it is easy to do comparative study of drilling investigation. The features of the Atera fault, which have been dislocated by the 1586 Tensho earthquake, are as follows. Total length is about 70 km. That general trend is NW45 degree with a left-lateral strike slip. Slip rate is estimated as 3-5 m / 1000 years. Seismicity is very low at present and lithologies around the fault are basically granitic rocks and rhyolite. Six boreholes have been drilled from the depth of 400 m to 630 m. Four of these boreholes (Hatajiri, Fukuoka, Ueno and Kawaue) are located on a line crossing in a direction perpendicular to the Atera fault. In the Kawaue well, mostly fractured and alternating granitic rock continued from the surface to the bottom at 630 m. X-ray fluorescence analysis (XRF) is conducted to estimate the amount of major chemical elements using the glass bead method for core samples. The amounts of H20+ are about from 0.5 to 2.5 weight percent. This fractured zone is also characterized by the logging data such as low resistivity, low P-wave velocity, low density and high neutron porosity. The 1995 Kobe (Hyogo-ken Nanbu) earthquake occurred along the NE-SW-trending Rokko-Awaji fault system, and the Nojima fault appeared on the surface on Awaji Island when this

  8. The Pacific and Philippine Sea slabs in contact beneath Tokyo, central Japan: their roles in defining hazardous interaction earthquakes and in limiting the southern extent of Tohoku-oki aftershocks

    Science.gov (United States)

    Okaya, D. A.; Sato, H.; Lavier, L. L.; Tan, E.; Wu, F. T.; Hirata, N.

    2011-12-01

    The M9 Tohoku-oki earthquake produced over 11,000 >M3 aftershocks within the first four months after its 2011 March 11 occurrence date. The majority of these aftershocks define the earthquake source region between the subducting Pacific plate (PAC) and its overlying Eurasian plate (EUR) along the Japan Trench. While this portion of the trench boundary extends southward to the Boso triple junction (latitude ~34.3 oN), the Tohoku-oki aftershocks predominantly terminate at ~35.7 oN. Between these two latitudes there is a marked dropoff in aftershocks, most noticably offshore of Boso Peninsula, eastern Kanto, which we refer to as the off-Boso aftershock gap. Inside this gap, aftershocks that have occurred form two narrow-width streaks that radiate from the triple junction and extend into central Kanto. There is a correlation between the location of the off-Boso aftershock gap and the northern extent of the Philippine Sea plate (PHS). The PHS is sandwiched between the PAC-EUR plates beneath Kanto. While the majority of Tohoku-oki aftershocks occur within the one-slab PAC-EUR system to the north, the off-Boso gap is updip of where the PHS slab is resident inside the PAC-EUR mantle wedge. Furthermore, the northern of the two aftershock streaks spatially correlates with the downdip extent of the PHS with many located at the PHS-PAC contact based on published tomographic/seismicity studies. The presence of PHS changes the conditions of PAC-EUR slip. Preliminary finite-source studies from web sources (e.g., Univ Tokyo, Harvard) show that Tohoku-oki rupture terminated just north of the off-Boso gap. Apparently, the presence of the Philippine Sea plate may have been a contributing factor to inhibiting this rupture from propagating further southward. The megathrust source faults beneath Kanto are associated with the tops of Philippine Sea and Pacific plates. These shallow source faults have been the focus of much recent geological and geophysical study including seismicity and

  9. CD40/CD40L Dyad in the Inflammatory and Immune Responses in the Central Nervous System

    Institute of Scientific and Technical Information of China (English)

    Keqiang Chen; Jian Huang; Wanghua Gong; Lingzhi Zhang; Peichu Yu; Ji Ming Wang

    2006-01-01

    CD40 and its cognate ligand (CD40L) are a pair of regulators of pro-inflammatory and immune responses. In the central nervous system (CNS), CD40 is expressed on a variety of cells, including vascular endothelial cells, smooth muscle cells, astrocytes and microglia (the brain macrophages, being the most sensitive cell type to respond to CD40 ligand). Interaction between CD40 on microglia and CD40L presented by infiltrating T lymphocytes and other resident CNS cells triggers a series of intracellular signaling events that promote the production of a wide array of cytokines, chemokines and neurotoxins. Thus, both molecules serve as amplifiers of pro-inflammatory and immune responses in the CNS and constitute important molecular targets for therapeutic intervention of diseases.

  10. Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

    DEFF Research Database (Denmark)

    Khorooshi, Reza; Owens, Trevor

    2010-01-01

    Innate glial response is critical for the induction of inflammatory mediators and recruitment of leukocytes to sites of the injury in the CNS. We have examined the involvement of type I IFN signaling in the mouse hippocampus following sterile injury (transection of entorhinal afferents). Type I I...

  11. Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity

    NARCIS (Netherlands)

    Imre, G; Fokkema, DS; Den Boer, JA; Ter Horst, GJ

    2006-01-01

    The present dose-response study sought to determine the effects of subanesthetic dosages (4-16 mg/kg) of ketamine on locomotion, sensorimotor gating (PP1), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia. In addition, we examined

  12. Inhibition of centrally-evoked pressor responses by neurohypophyseal peptides and their fragments

    NARCIS (Netherlands)

    Versteeg, C.A.M.; Bohus, B.; Jong, Wybren de

    1982-01-01

    Intracerebroventricular administration of fragments of [arginine8]-vasopressin (AVP) such as AVP1–6 and AVP7–9 attenuated the pressor response evoked by electrical stimulation of the mesencephalic reticular formation in urethane-anaesthetized rats. Oxytocin (OXT) and the fragment OXT7–9 were also ac

  13. Central blockade of (methyl-)atropine on carbachol drinking: A dose-response study

    NARCIS (Netherlands)

    Terpstra, G.K.; Slangen, J.L.

    1972-01-01

    Administration of carbachol in the tractus diagonalis in rats elicited drinking and no eating. Norepinephrine administered in the same place did not induce drinking or eating. The specific drinking response induced by stimulation with 7.2 nmol (= 1.3 μg) of carbachol was gradually inhibited by prece

  14. The CRF family of neuropeptides and their receptors - mediators of the central stress response.

    Science.gov (United States)

    Dedic, Nina; Chen, Alon; Deussing, Jan M

    2017-03-01

    Dysregulated stress neurocircuits, caused by genetic and/or environmental changes, underlie the development of many neuropsychiatric disorders. Corticotropin-releasing factor (CRF) is the major physiological activator of the hypothalamic-pituitary-adrenal (HPA) axis and consequently a primary regulator of the mammalian stress response. Together with its three family members, urocortins (UCNs) 1, 2, and 3, CRF integrates the neuroendocrine, autonomic, metabolic and behavioral responses to stress by activating its cognate receptors CRFR1 and CRFR2. Here we review the past and current state of the CRH/CRHR field, ranging from pharmacological studies to genetic mouse models and virus-mediated manipulations. Although it is well established that CRF/CRFR1 signaling mediates aversive responses, including anxiety and depression-like behaviors, a number of recent studies have challenged this viewpoint by revealing anxiolytic and appetitive properties of specific CRF/CRFR1 circuits. In contrast, the UCN/CRFR2 system is less well understood and may possibly also exert divergent functions on physiology and behavior depending on the brain region,underlying circuit, and/or experienced stress conditions. A plethora of available genetic tools, including conventional and conditional mouse mutants targeting CRF system components, has greatly advanced our understanding about the endogenous mechanisms underlying HPA system regulation and CRH/UCN-related neuronal circuits involved in stress-related behaviors. Yet, the deailed pathways and molecular mechanism by which the CRH/UCN-system translates negative or positive stimuli into the final, integrated biological response are not completely understood. The utilization of future complementary methodologies, such as cell-type specific Cre-driver lines, viral and optogenetic tools will help to further dissect the function of genetically defined CRH/UCN neurocircuits in the context of adaptive and maladaptive stress responses. Copyright

  15. p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1β and footshock in conscious rats

    Institute of Scientific and Technical Information of China (English)

    Rui-mao ZHENG; Chang-jiang ZOU; Shi-gong ZHU

    2004-01-01

    AIM: To investigate the roles of p38 mitogen-activated protein kinase (p38 MAPK) in the cardiovascular and behavioral responses induced by intracerebral ventricular injection (icv) of interleukin- 1 β (IL- 1 β) or footshock.METHODS: We examined the effects of p38 MAPK on mean artery blood pressure (mABP), heart rate (HR), and motor activity (MA) during central administration of IL- 1 β, or footshock after icv SB203580 (a specific inhibitor of the p38 MAPK) with Cardiovascular and Behavior Telemetry System in conscious SD rats. RESULTS: (1) IL-1 β (icy) or footshock remarkably rise the mABP, and the maximal changes are (7.8± 1.8) and (12.3±3.5) mmHg,respectively, which was abrogated by the pretreatment with p38 inhibitor SB203580 intracerebroventricularly. (2)Compared with icv saline group, the motor activity was significantly decreased in SB203580 group with maximal changes (-7.6± 1.1) counts/min after footshock. CONCLUSION: p38 MAPK plays an important role in the pressor response induced by central administration of IL- 1 β or footshock and change of motor activity after footshock in conscious rats.

  16. Blunted sympathoinhibitory responses in obesity-related hypertension are due to aberrant central but not peripheral signalling mechanisms.

    Science.gov (United States)

    How, Jackie M Y; Wardak, Suhail A; Ameer, Shaik I; Davey, Rachel A; Sartor, Daniela M

    2014-04-01

    The gut hormone cholecystokinin (CCK) acts at subdiaphragmatic vagal afferents to induce renal and splanchnic sympathoinhibition and vasodilatation, via reflex inhibition of a subclass of cardiovascular-controlling neurons in the rostroventrolateral medulla (RVLM). These sympathoinhibitory and vasodilator responses are blunted in obese, hypertensive rats and our aim in the present study was to determine whether this is attributable to (i) altered sensitivity of presympathetic vasomotor RVLM neurons, and (ii) aberrant peripheral or central signalling mechanisms. Using a diet-induced obesity model, male Sprague-Dawley rats exhibited either an obesity-prone (OP) or obesity-resistant (OR) phenotype when placed on a medium high fat diet for 13-15 weeks; control animals were placed on a low fat diet. OP animals had elevated resting arterial pressure compared to OR/control animals (P obesity-related hypertension are due to alterations in RVLM neuronal responses, resulting from aberrant central but not peripheral signalling mechanisms. In obesity, blunted sympathoinhibitory mechanisms may lead to increased regional vascular resistance and contribute to the development of hypertension.

  17. Central autonomic nervous system response to autonomic challenges is altered in patients with a previous episode of Takotsubo cardiomyopathy.

    Science.gov (United States)

    Pereira, Vitor H; Marques, Paulo; Magalhães, Ricardo; Português, João; Calvo, Lucy; Cerqueira, João J; Sousa, Nuno

    2016-04-01

    Takotsubo cardiomyopathy is an intriguing disease characterized by acute transient left ventricular dysfunction usually triggered by an episode of severe stress. The excessive levels of catecholamines and the overactivation of the sympathetic system are believed to be the main pathophysiologic mechanisms of Takotsubo cardiomyopathy, but it is unclear whether there is a structural or functional signature of the disease. In this sense, our aim was to characterize the central autonomic system response to autonomic challenges in patients with a previous episode of Takotsubo cardiomyopathy when compared with a control group of healthy volunteers. Functional magnetic resonance imaging (fMRI) was performed in four patients with a previous episode of Takotsubo cardiomyopathy (average age of 67 ± 12 years) and in eight healthy volunteers (average age of 66 ± 5 years) while being submitted to different autonomic challenges (cold exposure and Valsalva manoeuvre). The fMRI analysis revealed a significant variation of the blood oxygen level dependent signal triggered by the Valsalva manoeuvre in specific areas of the brain involved in the cortical control of the autonomic system and significant differences in the pattern of activation of the insular cortex, amygdala and the right hippocampus between patients with Takotsubo cardiomyopathy and controls, even though these regions did not present significant volumetric changes. The central autonomic response to autonomic challenges is altered in patients with Takotsubo cardiomyopathy, thus suggesting a dysregulation of the central autonomic nervous system network. Subsequent studies are needed to unveil whether these alterations are causal or predisposing factors to Takotsubo cardiomyopathy. © The European Society of Cardiology 2015.

  18. PALYNOLOGICAL INVESTIGATION OF THE MATTO SUBMERGED FOREST ON THE CONTINENTAL SHELF IN THE JAPAN SEA OFF THE TEDORI-GAWA ALLUVIAL FAN, THE HOKURIKU REGION, CENTRAL JAPAN%日本中部北陆地区大陆架松任市水下森林的孢粉学研究

    Institute of Scientific and Technical Information of China (English)

    藤则雄

    2003-01-01

    松任市水下森林于1998年发现,位于日本中部北陆地区松任市Hama sogo和Kurabe附近手取河现代冲积扇2-3km外的20-30 m水下,呈树桩、树根或直立的树干保存.这一发现证明在早全新世当地有森林发育,森林的主要成分有Alnus,Quercus,Morus,Fraxinus.14C年代为距今8 000-10 000a.孢粉分析显示沼泽植物,如Alnus,Salix,Cryptomeria,Gramineae,Numphaceae丰富,Lepidobalanus,Castanea,Fraxinus常见,而Fagus cf. crenata,Pinus少见.硅藻表明其在森林发育时期当地为淡水或小湖泊.因此,当时森林生长在古手取河冲积扇边缘的沼泽地区,寒温带的Sasa-Fagetum crenate群丛(Association)的Alnus japonica群落(Community)广泛分布,推测年均温比现代要低几度.水下森林的形成时间和冰期后气候变暖所引起的海平面上升相一致,推测可能由于海水水位上升,古手取河洪水从上游冲下的碎屑物掩埋了当时的森林形成了现在的水下森林.因为日本海沿岸的洋流冲刷而使得这些化石森林显露出来.当前的水下森林和Nyuzen水下森林是目前世界上已知仅有的两处大陆架上的水下森林.%The Matto submerged forest was found in spring of 1998 as stumps, roots and erect trunks from the continentalshelf at depth between 20 and 30 m, and in 2 to 3 km off the recent marginal area of the Tedori-gawa alluvial fan at Hama-sogoand Kurabe, Matto City, the Hokuriku region, Central Japan. This discovery proves the development of ancient forest in theearly Holocene. Main tree remnants of the forest are Alnus, Quercus (Lepidobalanus), Morus and Fraxinus, the most commonlypreserved genera. These trees had grown on the now submerged seaward margin of the old Tedori-gawa alluvial fan. An age ofthe submerged forest determined by the C-14 method is about 10 000 to 8 000 years B.P. According to pollen analyses, suchmarshy plants as Alnus, Salix, Cryptomeria, Gramineae and Nymphaceae are abundant, Lepidobalanus, Castanea

  19. [Trichophyton tonsurans infection among judo practitioners who attended the National Junior High School Judo Tournament in Japan (2005): incidence and therapeutic response].

    Science.gov (United States)

    Suganami, Morio; Hirose, Nobuyoshi; Shiraki, Yumi; Hiruma, Masataro; Ikeda, Shigaku

    2006-01-01

    The spread of Trichophyton tonsurans infection among high school students and university undergraduates who practice Judo is an emerging problem in Japan and other countries. However, the extent of infection among Judo practitioners in junior high school in Japan is unknown. We conducted an epidemiological study of T. tonsurans infection among students who participated in the national junior high school Judo tournament in 2005. Of the 1,039 tournament participants invited to undergo screening, 496 (218 boys and 278 girls) consented, and 45 participants (9.1%) were found to be positive by hairbrush culture. We found the following to be relative risk factors for T. tonsurans infection: 1) male gender, 2) frequent judo practice in groups at either a high school or a dojo, 3) presence of tinea corporis in practice partners, 4) history of tinea corporis, 5) classification in lower-weight categories. 45 culture positive subjects were offered treatment and re-examined by hairbrush culture 3 months later. All twelve of them had negative cultures after miconazole shampoo treatment. A half of 12 subjects who had systemic antifungal therapy with itraconazole had positive culture. These observations suggest that T. tonsurans infection is rapidly spreading among junior high school Judo players in Japan. We speculate that the outbreak is caused, at least in part, by ignorance of the disease among Judo students, coaches and officials due to the high incidence of carriers and the mild or asymptomatic form of disease seen in infected individuals. Appropriate measures should be taken immediately to prevent more severe outbreak of this disease.

  20. Geomorphic and exhumational response of the Central American Volcanic Arc to Cocos Ridge subduction

    Science.gov (United States)

    Morell, Kristin D.; Kirby, Eric; Fisher, Donald M.; van Soest, Matthijs

    2012-04-01

    The timing of collision of the Cocos Ridge at the Middle America Trench remains one of the outstanding questions in the tectonic evolution of the Central American convergent margin. New analyses of the tectonic geomorphology of the Cordillera de Talamanca, the extinct volcanic arc inboard of the Cocos Ridge, coupled with low temperature thermochronometry data, provide insight into the cooling and erosional history of the arc from late Miocene to present. We identify a low-relief surface at high elevation along the northeastern flanks of the range, which represents a relict erosional landscape cut across shallow plutonic rocks of the arc edifice. Longitudinal profiles of rivers on this surface are isolated from steep downstream sections by prominent knickzones that are interpreted to reflect a migrating wave of transient incision generated during differential rock uplift of the range. Reconstruction of pre-incision profiles suggests that rock uplift during the growth of the Cordillera de Talamanca is no greater than ˜2 km. This inference is corroborated by results from our apatite (U-Th)/He and apatite fission track analyses along an elevation transect on Mt. Chirripó, the highest mountain in the Cordillera de Talamanca. Low-temperature cooling ages overlap significantly with published high-temperature40Ar/39Ar ages; the combined results imply that rapid cooling in the late Miocene was related to secular cooling of a shallow pluton, rather than exhumation. Our results imply that rapid incision along downstream channel segments, differential rock uplift, and growth of the Talamanca as a bivergent orogenic wedge associated with the onset of Cocos Ridge subduction are relatively young characteristics of the range. A review of previously published radiometric ages and revised plate reconstructions for the late Miocene further suggest that the cessation of arc volcanism in both the Cordillera de Talamanca and the Cordillera Central of western Panama was coeval with the

  1. Trauma and posttraumatic stress disorder in Japan: Results from the World Mental Health Japan Survey

    OpenAIRE

    Kawakami, Norito; Tsuchiya, Masao; Umeda, Maki; Koenen,Karestan C; Kessler, Ronald C.

    2014-01-01

    The purpose of the study was to report the prevalence of trauma exposure and PTSD, conditional risk of PTSD associated with each trauma exposure in the community population in Japan. An interview survey was conducted of a random sample of adult residents in 11 communities of Japan. Among 4134 respondents (response rate, 55%), data from those who completed the part 2 interview (n = 1682) were analyzed with a weight for this subsample. Lifetime experiences of 27 trauma events and PTSD were asse...

  2. Influence of stimulus and oral adaptation temperature on gustatory responses in central taste-sensitive neurons.

    Science.gov (United States)

    Li, Jinrong; Lemon, Christian H

    2015-04-01

    The temperature of taste stimuli can modulate gustatory processing. Perceptual data indicate that the adapted temperature of oral epithelia also influences gustation, although little is known about the neural basis of this effect. Here, we electrophysiologically recorded orosensory responses (spikes) to 25°C (cool) and 35°C (warm) solutions of sucrose (0.1 and 0.3 M), NaCl (0.004, 0.1, and 0.3 M), and water from taste-sensitive neurons in the nucleus of the solitary tract in mice under varied thermal adaptation of oral epithelia. Conditions included presentation of taste stimuli isothermal to adaptation temperatures of 25°C (constant cooling) and 35°C (constant warming), delivery of 25°C stimuli following 35°C adaptation (relative cooling), and presentation of 35°C stimuli following 25°C adaptation (relative warming). Responses to sucrose in sucrose-oriented cells (n = 15) were enhanced under the constant and relative warming conditions compared with constant cooling, where contiguous cooling across adaptation and stimulus periods induced the lowest and longest latency responses to sucrose. Yet compared with constant warming, cooling sucrose following warm adaptation (relative cooling) only marginally reduced activity to 0.1 M sucrose and did not alter responses to 0.3 M sucrose. Thus, warmth adaptation counteracted the attenuation in sucrose activity associated with stimulus cooling. Analysis of sodium-oriented (n = 25) neurons revealed adaptation to cool water, and cooling taste solutions enhanced unit firing to 0.004 M (perithreshold) NaCl, whereas warmth adaptation and stimulus warming could facilitate activity to 0.3 M NaCl. The concentration dependence of this thermal effect may reflect a dual effect of temperature on the sodium reception mechanism that drives sodium-oriented cells.

  3. Macrophage biology plays a central role during ionizing radiation-elicited tumor response

    Directory of Open Access Journals (Sweden)

    Qiuji Wu

    2017-08-01

    Full Text Available Radiation therapy is one of the major therapeutic modalities for most solid tumors. The anti-tumor effect of radiation therapy consists of the direct tumor cell killing, as well as the modulation of tumor microenvironment and the activation of immune response against tumors. Radiation therapy has been shown to promote immunogenic cells death, activate dendritic cells and enhance tumor antigen presentation and anti-tumor T cell activation. Radiation therapy also programs innate immune cells such as macrophages that leads to either radiosensitization or radioresistance, according to different tumors and different radiation regimen studied. The mechanisms underlying radiation-induced macrophage activation remain largely elusive. Various molecular players such as NF-κB, MAPKs, p53, reactive oxygen species, inflammasomes have been involved in these processes. The skewing to a pro-inflammatory phenotype thus results in the activation of anti-tumor immune response and enhanced radiotherapy effect. Therefore, a comprehensive understanding of the mechanism of radiation-induced macrophage activation and its role in tumor response to radiation therapy is crucial for the development of new therapeutic strategies to enhance radiation therapy efficacy.

  4. Antiviral Type I and Type III Interferon Responses in the Central Nervous System

    Directory of Open Access Journals (Sweden)

    Thomas Michiels

    2013-03-01

    Full Text Available The central nervous system (CNS harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB from toxic substances and pathogens carried in the bloodstream. Yet, neurotropic viruses can reach the CNS either by crossing the BBB after viremia, or by exploiting motile infected cells as Trojan horses, or by using axonal transport. Type I and type III interferons (IFNs are cytokines that are critical to control early steps of viral infections. Deficiencies in the IFN pathway have been associated with fatal viral encephalitis both in humans and mice. Therefore, the IFN system provides an essential protection of the CNS against viral infections. Yet, basal activity of the IFN system appears to be low within the CNS, likely owing to the toxicity of IFN to this organ. Moreover, after viral infection, neurons and oligodendrocytes were reported to be relatively poor IFN producers and appear to keep some susceptibility to neurotropic viruses, even in the presence of IFN. This review addresses some trends and recent developments concerning the role of type I and type III IFNs in: i preventing neuroinvasion and infection of CNS cells; ii the identity of IFN-producing cells in the CNS; iii the antiviral activity of ISGs; and iv the activity of viral proteins of neurotropic viruses that target the IFN pathway.

  5. Antiviral Type I and Type III Interferon Responses in the Central Nervous System

    Science.gov (United States)

    Sorgeloos, Frédéric; Kreit, Marguerite; Hermant, Pascale; Lardinois, Cécile; Michiels, Thomas

    2013-01-01

    The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens carried in the bloodstream. Yet, neurotropic viruses can reach the CNS either by crossing the BBB after viremia, or by exploiting motile infected cells as Trojan horses, or by using axonal transport. Type I and type III interferons (IFNs) are cytokines that are critical to control early steps of viral infections. Deficiencies in the IFN pathway have been associated with fatal viral encephalitis both in humans and mice. Therefore, the IFN system provides an essential protection of the CNS against viral infections. Yet, basal activity of the IFN system appears to be low within the CNS, likely owing to the toxicity of IFN to this organ. Moreover, after viral infection, neurons and oligodendrocytes were reported to be relatively poor IFN producers and appear to keep some susceptibility to neurotropic viruses, even in the presence of IFN. This review addresses some trends and recent developments concerning the role of type I and type III IFNs in: i) preventing neuroinvasion and infection of CNS cells; ii) the identity of IFN-producing cells in the CNS; iii) the antiviral activity of ISGs; and iv) the activity of viral proteins of neurotropic viruses that target the IFN pathway. PMID:23503326

  6. Dose-dependent response of central dopaminergic systems to buspirone in mice.

    Science.gov (United States)

    Jadhav, S A; Gaikwad, R V; Gaonkar, R K; Thorat, V M; Gursale, S C; Balsara, J J

    2008-10-01

    Buspirone, a partial agonist of 5-hydroxytryptaminelA autoreceptors, preferentially blocks the presynaptic rather than the postsynaptic D2 dopamine (DA) receptors. Behavioural effects of a wide dose range of buspirone were therefore studied in mice. Buspirone at 0.625 to 5 mg/kg ip induced stereotyped cage climbing behaviour which was antagonized by pretreatment with haloperidol, alpha-methyl-p-tyrosine and small doses of apomorphine. Buspirone at 10, 20 and 40 mg/kg ip induced catalepsy and antagonized oral stereotypies induced by high doses of apomorphine and methamphetamine and apomorphine-induced cage climbing behaviour. The findings indicate that buspirone at 0.625 to 5 mg/kg selectively blocks the presynaptic mesolimbic D2 DA autoreceptors and releases DA which stimulates the postsynaptic mesolimbic D2 and D1 DA receptors and induces cage climbing behaviour. Buspirone, at 10, 20 and 40 mg/kg blocks the postsynaptic striatal and mesolimbic D2 and D1 DA receptors. Pretreatment with 1-tryptophan, dexfenfluramine and fluoxetine antagonized buspirone induced cage climbing behaviour and potentiated buspirone induced catalepsy. Pretreatment with trazodone, mianserin and p-chlorophenylalanine potentiated buspirone induced cage climbing behaviour and antagonized buspirone induced catalepsy. The results indicate that drugs which influence the activity of central serotonergic systems modulate the intensity of buspirone induced cage climbing behaviour and catalepsy.

  7. Groundwater contamination in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Tase, Norio [Univ. of Tsukuba, Ibaraki (Japan)

    1992-07-01

    Problems on groundwater contamination in Japan are briefly summarized in this paper. Although normal physical conditions in Japan restrict the possibilities of groundwater contamination, human activities are threatening groundwater resources. A survey by the Environment Agency of Japan showed nationwide spreading of organic substances, such as trichloroethylene as well as nitrogen compounds. Synthetic detergents have also been detected even in rural areas and in deep confined aquifers, although their concentrations are not as high. Public awareness of agrichemical or pesticides abuse, especially from golf courses, is apparent. Other problems such as nitrate-nitrogen, leachate from landfills, and the leaking of underground storage tanks are also discussed. 9 refs., 3 figs., 4 tabs.

  8. Groundwater contamination in Japan

    Science.gov (United States)

    Tase, Norio

    1992-07-01

    Problems on groundwater contamination in Japan are briefly summarized in this paper. Although normal physical conditions in Japan restrict the possibilities of groundwater contamination, human activities are threatening groundwater resources. A survey by the Environment Agency of Japan showed nationwide spreading of organic substances, such as trichloroethylene as well as nitrogen compounds. Synthetic detergents have also been detected even in rural areas and in deep confined aquifers, although their concentrations are not as high. Public awareness of agrichemical or pesticides abuse, especially from golf courses, is apparent. Other problems such as nitrate-nitrogen, leachate from landfills, and the leaking of underground storage tanks are also discussed.

  9. Assessment of nonlinear site response at ocean bottom seismograph sites based on S-wave horizontal-to-vertical spectral ratios: a study at the Sagami Bay area K-NET sites in Japan

    Science.gov (United States)

    Dhakal, Yadab P.; Aoi, Shin; Kunugi, Takashi; Suzuki, Wataru; Kimura, Takeshi

    2017-02-01

    We analyzed S-wave horizontal-to-vertical (S-H/V) spectral ratios at six ocean bottom seismograph (OBS) sites of K-NET located in the Sagami Bay area of Japan for nonlinear site responses. The degree of nonlinearity was computed by comparing the S-H/V spectral ratios for strong motions (PGA ≥ 20 cm/s2) with those for weak motions (PGA offshore earthquakes with a large magnitude. However, frequencies lower than about 2 Hz are not affected by the nonlinear site response in the analyzed data ranges (PGA < 467 cm/s2). These results indicate the need for careful utilization of recorded strong motions at OBS sites for applications such as real-time ground motion predictions as front detections.

  10. CJFA Delegation Led by Song Jian Visits Japan

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>At the invitation of the Japan-China Friendship Centre,a delegation of the China-Japan Friendship Association(CJFA) led by its President Song Jian paid a goodwill visit to Japan from December 3 to 10,2006.In Tokyo Song Jian and his party paid an official call on leaders of the Japanese ruling party and parties not in office and a number of important political figures including Prime Minister Shinzo Abe,Speaker of the House of Representatives Yohei Kono,Foreign Minister Taro Aso,head of the New Komeito Party Akihiro Ota,leader of the Democratic Party Ichiro Ozawa,Chairman of the Central Committee of the Communist Party of Japan Kazuo Shii,and Chairman of the Socialist Party Mizuho Fukushima,and fully exchanged views with the leaders of the seven Japan-China friendship organizations on making great efforts to promote people-to-people friendly exchanges.

  11. Alterations in peripheral and central components of the auditory brainstem response: a neural assay of tinnitus.

    Directory of Open Access Journals (Sweden)

    Andrea S Lowe

    Full Text Available Chronic tinnitus, or "ringing of the ears", affects upwards of 15% of the adult population. Identifying a cost-effective and objective measure of tinnitus is needed due to legal concerns and disability issues, as well as for facilitating the effort to assess neural biomarkers. We developed a modified gap-in-noise (GIN paradigm to assess tinnitus in mice using the auditory brainstem response (ABR. We then compared the commonly used acoustic startle reflex gap-prepulse inhibition (gap-PPI and the ABR GIN paradigm in young adult CBA/CaJ mice before and after administrating sodium salicylate (SS, which is known to reliably induce a 16 kHz tinnitus percept in rodents. Post-SS, gap-PPI was significantly reduced at 12 and 16 kHz, consistent with previous studies demonstrating a tinnitus-induced gap-PPI reduction in this frequency range. ABR audiograms indicated thresholds were significantly elevated post-SS, also consistent with previous studies. There was a significant increase in the peak 2 (P2 to peak 1 (P1 and peak 4 (P4 to P1 amplitude ratios in the mid-frequency range, along with decreased latency of P4 at higher intensities. For the ABR GIN, peak amplitudes of the response to the second noise burst were calculated as a percentage of the first noise burst response amplitudes to quantify neural gap processing. A significant decrease in this ratio (i.e. recovery was seen only at 16 kHz for P1, indicating the presence of tinnitus near this frequency. Thus, this study demonstrates that GIN ABRs can be used as an efficient, non-invasive, and objective method of identifying the approximate pitch and presence of tinnitus in a mouse model. This technique has the potential for application in human subjects and also indicates significant, albeit different, deficits in temporal processing in peripheral and brainstem circuits following drug induced tinnitus.

  12. Mantle Response to a Slab Gap and Three-dimensional Slab Interaction in Central America

    Science.gov (United States)

    Jadamec, M. A.; Fischer, K. M.

    2013-12-01

    Seismically constrained global slab geometries suggest the Middle America-South American subduction system contains a gap on the order of 500 km separating the east-dipping Cocos and Nazca slabs at depth (Gudmundsson and Sambridge, 1998; Syracuse and Abers, 2006; Hayes et al., 2012). The location of the gap correlates with tectonic features impinging on the Pacific side of the Middle America trench, in particular the incoming young buoyant oceanic lithosphere and oceanic ridges associated with the Galapagos hotspot and Cocos-Nazca spreading center (Protti et al., 1994; Mann et al., 2007; Muller et al., 2008). Moreover, geochemical studies focusing on the arc chemistry in the Central American volcanic front argue for a slab window of some kind in this region (Johnston and Thorkelson, 1997; Abratis and Worner, 2001; Hoernle et al., 2008). We use high-resolution, three-dimensional (3D) geodynamic modeling of the Middle America-South American subduction system to investigate the role of the incoming young oceanic lithosphere and a gap between the Cocos and Nazca slabs in controlling mantle flow velocity and geochemical signatures beneath Central America. The geodynamic models are geographically referenced with the geometry and thermal structure for the overriding and subducting plates based on geological and geophysical observables and constructed with the multi-plate subduction generator code, SlabGenerator (Jadamec and Billen, 2010; Jadamec et al., 2012; Jadamec and Billen, 2012). The viscous flow simulations are solved using the mantle convection finite-element code, CitcomCU (Zhong, 2006), modified by Jadamec and Billen (2010) to take into account the experimentally derived flow law for olivine and allow for variable 3D plate interface geometries and magnitudes of inter-plate coupling. The 3D numerical models indicate the gap between the Cocos and Nazca slabs serves as a conduit for Pacific-Cocos mantle to pass into the Caribbean, with toroidal flow around the

  13. Unravel biophysical factors on river water quality response in Chilean Central-Southern watersheds.

    Science.gov (United States)

    Yevenes, Mariela A; Arumí, José L; Farías, Laura

    2016-05-01

    Identifying the key anthropogenic (land uses) and natural (topography and climate) biophysical drivers affecting river water quality is essential for efficient management of water resources. We tested the hypothesis that water quality can be predicted by different biophysical factors. Multivariate statistics based on a geographical information system (GIS) were used to explore the influence of factors (i.e., precipitation, topography, and land uses) on water quality (i.e., nitrate (NO 3 (-)), phosphate (PO 4 (3-)), silicate (Si(OH)4), dissolved oxygen (DO), suspended solids (TSS), biological oxygen demand (DO), temperature (T), conductivity (EC), and pH) for two consecutive years in the Itata and Biobío river watersheds, Central Chile (36° 00' and 38° 30'). The results showed that (NO 3 (-)), (PO 4 (3-)), Si(OH)4, TSS, EC, and DO were higher during rainy season (austral fall, winter, and spring), whereas BOD and temperature were higher during dry season. The spatial variation of these parameters in both watersheds was related to land use, topography (e.g., soil moisture, soil hydrological group, and erodability), and precipitation. Soil hydrological group and soil moisture were the strongest explanatory predictors for PO 4 (3-) , Si(OH)4 and EC in the river, followed by land use such as agriculture for NO 3 (-) and DO and silviculture for TSS and Si(OH)4. High-resolution water leaching and runoff maps allowed us to identify agriculture areas with major probability of water leaching and higher probability of runoff in silviculture areas. Moreover, redundancy analysis (RDA) revealed that land uses (agriculture and silviculture) explained in 60 % the river water quality variation. Our finding highlights the vulnerability of Chilean river waters to different biophysical drivers, rather than climate conditions alone, which is amplified by human-induced degradation.

  14. Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide.

    Science.gov (United States)

    Moreira, Thiago Santos; Takakura, Ana Carolina Thomaz; Sato, Monica Akemi; Menani, José Vanderlei; Colombari, Eduardo

    2006-06-01

    In the present study, we investigated the effects of pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) (nitric oxide synthase inhibitor) injected intravenously (IV) on the hypotension, bradycardia, and vasodilation produced by moxonidine (alpha2-adrenergic/imidazoline receptor agonist) injected into the fourth brain ventricle (4th V) in rats submitted to acute hypertension that results from baroreflex blockade by bilateral injections of kynurenic acid (kyn, glutamatergic receptor antagonist) into the nucleus of the solitary tract (NTS) or in normotensive rats. Male Wistar rats (n=5 to 7/group) anesthetized with IV urethane (1.0 g kg(-1) of body weight) and alpha-chloralose (60 mg kg(-1) of body weight) were used. Bilateral injections of kyn (2.7 nmol 100 nL(-1)) into the NTS increased baseline mean arterial pressure (148 +/- 11 mm Hg, vs. control: 102 +/- 4 mm Hg) and baseline heart rate (417 +/- 11 bpm, vs. control: 379 +/- 6 bpm). Moxonidine (20 nmol microL(-1)) into the 4th V reduced mean arterial pressure and heart rate to similar levels in rats treated with kyn into the NTS (68 +/- 9 mm Hg and 359 +/- 7 bpm) or in control normotensive rats (66 +/- 7 mm Hg and 362 +/- 8 bpm, respectively). The pretreatment with L-NAME (25 micromol kg, IV) attenuated the hypotension produced by moxonidine into the 4th V in rats treated with kyn (104 +/- 6 mm Hg) or in normotensive rats (95 +/- 8 mm Hg), without changing bradycardia. Moxonidine into the 4th V also reduced renal, mesenteric, and hindquarter vascular resistances in rats treated or not with kyn into the NTS and the pretreatment with L-NAME IV reduced these effects of moxonidine. Therefore, these data indicate that nitric oxide mechanisms are involved in hypotension and mesenteric, renal, and hindquarter vasodilation induced by central moxonidine in normotensive and in acute hypertensive rats.

  15. null Kirishima, Japan Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The shield volcano consists of more than 20 eruptive centers over a 20 x 30 km area that also includes Japan's first national park. Sixty-nine eruptions have been...

  16. Japan's radiant architecture

    National Research Council Canada - National Science Library

    Ruairí O'Brien

    2014-01-01

    .... If Japanese architecture in the last century could be seen as an expression of fast growth, destruction, rebirth and expansion, today's Japan promises to deliver a new hybrid of high and low tech...

  17. Vegetation dynamics and responses to climate change and human activities in Central Asia.

    Science.gov (United States)

    Jiang, Liangliang; Guli Jiapaer; Bao, Anming; Guo, Hao; Ndayisaba, Felix

    2017-12-01

    Knowledge of the current changes and dynamics of different types of vegetation in relation to climatic changes and anthropogenic activities is critical for developing adaptation strategies to address the challenges posed by climate change and human activities for ecosystems. Based on a regression analysis and the Hurst exponent index method, this research investigated the spatial and temporal characteristics and relationships between vegetation greenness and climatic factors in Central Asia using the Normalized Difference Vegetation Index (NDVI) and gridded high-resolution station (land) data for the period 1984-2013. Further analysis distinguished between the effects of climatic change and those of human activities on vegetation dynamics by means of a residual analysis trend method. The results show that vegetation pixels significantly decreased for shrubs and sparse vegetation compared with those for the other vegetation types and that the degradation of sparse vegetation was more serious in the Karakum and Kyzylkum Deserts, the Ustyurt Plateau and the wetland delta of the Large Aral Sea than in other regions. The Hurst exponent results indicated that forests are more sustainable than grasslands, shrubs and sparse vegetation. Precipitation is the main factor affecting vegetation growth in the Kazakhskiy Melkosopochnik. Moreover, temperature is a controlling factor that influences the seasonal variation of vegetation greenness in the mountains and the Aral Sea basin. Drought is the main factor affecting vegetation degradation as a result of both increased temperature and decreased precipitation in the Kyzylkum Desert and the northern Ustyurt Plateau. The residual analysis highlighted that sparse vegetation and the degradation of some shrubs in the southern part of the Karakum Desert, the southern Ustyurt Plateau and the wetland delta of the Large Aral Sea were mainly triggered by human activities: the excessive exploitation of water resources in the upstream areas

  18. Active Forearc Response to CO-NZ-CA Triple Junction Migration, Southern Central America

    Science.gov (United States)

    Morell, K.; Fisher, D.; Gardner, T. W.

    2007-12-01

    Southeast migration of the CO-NZ-CA triple junction at a rate of ~55 mm/yr results in an abrupt increase in convergence rate, slab thickness and subduction direction within the upper plate of the Central American convergent margin. At the triple junction, an active transform fault (the dextral Panama Fracture Zone) subducts beneath the Caribbean plate at the Middle America Trench, and juxtaposes the thick, orthogonal and shallow subduction of the Cocos plate against the thin, oblique and steeper subduction of the Nazca plate. New bedrock geology, Quaternary mapping and Ar/Ar dates of fluvial and volcanic deposits inboard of the triple junction provide evidence that both the outer and inner forearc of this system is actively responding to the dynamic changes presented by triple junction migration. Our results confirm that the Fila Costeña, a thin-skinned inner forearc thrust belt, is active and likely propagating in concert with triple junction migration. Mapping within the area overriding the Panama Fracture Zone indicates that thrusting develops only in those areas experiencing Cocos subduction; the thrust belt dies out coincident with the on-shore projection of the Panama Fracture Zone, and balanced cross-sections indicate a lateral gradient in the amount of shortening near the termination of the thrust belt. Along-strike variations in drainage basin morphometry suggest that drainage divides of the Fila Costeña are propagating to the southeast with the triple junction, resulting in hook-shaped drainage patterns and asymmetric basin shapes. A survey of a flight of 3-4 fluvial terraces along the Río Chiriquí Viejo indicates recent thrusting along a prominent thrust fault of the Fila Costeña. These terraces are also inset into multiple lahar flows with an upper surface tentatively constrained at ~507 ka based on an Ar/Ar hornblende plateau age. Recent work indicates that this thrust fault displaces surficial lahar deposits, suggesting that it must have become

  19. Assessing Land Management Changes and Population Dynamics in Central Burkina Faso in Response to Climate Change.

    Science.gov (United States)

    Kabore Bontogho, P. E.; Boubacar, I.; Afouda, A.; Joerg, H.

    2015-12-01

    Assessing landscape and population's dynamics at watershed level contribute to address anthropogenic aspect of climate change issue owing to the close link between LULC and climate changes. The objective of this study is to explore the dependencies of population to land management changes in Massili basin (2612 km²) located in central Burkina Faso. A set of three satellite scenes was acquired for the years 1990 (Landsat 7 ETM), 2002 (Landsat 7 ETM+) and 2013 (Landsat 8 OLI/TIRS) from the Global Land Cover Facility's (GLCF) website. Census data were provided by the National institute of statistics and demographic (INSD). The satellites images were classified using object-oriented classification method which was supported by historic maps and field data. Those were collected in order to allow for class definition, verification and accuracy assessments. Based on the developed land use maps, change analysis was carried out using post classification comparison in GIS. Finally, derived land use changes were compared with census data in order to explore links between population dynamics and the land use changes. It was found in 1990 that Massili watershed LULC was dominated by Tree/shrub savannah (69%, 1802.28 km2 ), Farm/Fallow was representing 22%, Gallery forest (4%), Settlement (3%), Barre soil (1%), Water bodies (1%). In 2002, the major landscape was Farm (54%). Tree/Shrub savannas were reduced to 36% while the Gallery Forest was decreased to1% of the basin area. The situation has also slightly changed in 2013 with an increase of the area devoted to farm/fallow and settlement at a rate of 3% and Gallery forest has increased to 4%. The changes in land use are in agreement with a notable increase in population. The analysis of census data showed that the number of inhabitants increased from 338 inhabitants per km2 in 1990 to 1150 inhabitants per km2 in 2013. As shown by statistical analysis (Kendall correlation tau=0.9), there is a close relation between both dynamics.

  20. Occupational asthma in Japan

    OpenAIRE

    Dobashi, Kunio

    2012-01-01

    Research into occupational asthma (OA) in Japan has been led by the Japanese Society of Occupational and Environmental Allergy. The first report about allergic OA identified konjac asthma. After that, many kinds of OA have been reported. Cases of some types of OA, such as konjac asthma and sea squirt asthma, have been dramatically reduced by the efforts of medical personnel. Recently, with the development of new technologies, chemical antigen-induced asthma has increased in Japan. Due to adva...

  1. Japan; Selected Issues

    OpenAIRE

    International Monetary Fund

    2012-01-01

    Japan has a universal public pension system. Social security spending is a key fiscal policy challenge in Japan. The 2004 pension reforms have increased the ratio of the government subsidy to the basic pension benefit. Three reform measures are necessary to improve pension finances: an increase in pension eligibility age, a reduction in the pension benefit, and an increase in contributions. Eliminating the preferential tax treatments of pension income and collecting pension contributions from...

  2. Age aspect of adaptive response of the central nervous system in the state of emotional pain

    Directory of Open Access Journals (Sweden)

    Demchenko Ye.M.

    2014-11-01

    Full Text Available The formation of higher adaptive response in the postoperative period was investigated in experiments on rats of two age groups. It was found inhibition of the orientation-motor and emotional activity in young (5-6 months and old rats (20-24 months with the greatear effect in animals of the first age group. In young rats the inhibition of spatial memory was observed – number of food-getting depleted reactions decreased by 28%. Cognitive deficit was accompanied by opposite changes in the content of free unsaturated fatty acids (C18: 2.3, respectively to age features: decreased by 46% in the cortex of young rats and increased by 2.5-fold in the hippocampus of old animals.

  3. Introductory Overview of Stone Heritages in Japan

    Science.gov (United States)

    Kato, Hirokazu; Oikawa, Teruki; Fujita, Masayo; Yokoyama, Shunji

    2013-04-01

    As one contribution to 'Global Heritage Stone Resources' (GHSR), some stone heritages in Japan, which are nominated in the interim list, are briefly introduced. The geology of Japanese Islands where are the one of the most active areas in the history of the Earth, is very complicated. Therefore Japanese Islands consist of various kinds of minerals and rocks. Some of them were used to make stone implements and accessories. Japanese people also used to the best possible advantage to built tombstone, gate, pavement ,and the basement and wall of the large building such as temples, shrines, castles and modern buildings. 1. Stone Heritages of Pre-historical age: In the late Pleistocene and the early Holocene, ancient Japanese used obsidian cooled rapidly from rhyolitic magma.to make small implements and accessories. For example, Shirataki, Hokkaido (north island) is the largest place producing obsidian in Japan where Paleolithic people made arrowhead, knives and so on. Another example, Jade yielded in Itoigawa City, Japan Sea coast of central Japan, was made in the metamorphic rock about five hundred million years ago. Itoigawa area is only one place where jade is abundantly produced in Japan. Ancient people had been already collected and processed to ornaments although it is very hard and traded in wide area more than several thousand years ago. 2. Stone Heritages of Historical age: 2.1 Archaeological remains: In the Kofun (old mound) period (250 to 538 AD), stone burial chambers were used for old mounds to preserve against the putrefaction and to protect from the theft. For example, Ishibutai Kofun ("ishi" means "stone" and "butai" means "stage") in Nara old capital city, southwest Japan, is the largest known megalithic structure made of granite in Japan. 2.2 Stone walls of some typical castles Stones used is because of not only the rich reserves of rocks but also restriction of transportation. Osaka (second biggest city) castle, are composed of Cretaceous granite

  4. Climate-related response of dust flux to the central equatorial Pacific over the past 150 kyr

    Science.gov (United States)

    Jacobel, A. W.; McManus, J. F.; Anderson, R. F.; Winckler, G.

    2017-01-01

    High resolution paleoclimate records from low latitudes are critical for understanding the role of the tropics in transmitting and generating feedbacks for high-latitude climate change on glacial-interglacial and millennial timescales. Here we present three new records of 230Thxs,0-normalized 232Th-derived dust fluxes from the central equatorial Pacific spanning the last 150 kyr at millennial-resolution. All three dust flux records share the "sawtooth" pattern characteristic of glacial-interglacial cycles in ice volume, confirming a coherent response to global climate forcing on long timescales. These records permit a detailed examination of millennial variability in tropical dust fluxes related to abrupt perturbations in oceanic and atmospheric circulation. Increases in dust flux in association with at least six of the longest Greenland stadials provide evidence that abrupt, high-latitude climate oscillations influenced the atmospheric aerosol load in the equatorial Pacific, with implications for both direct and indirect effects on the tropical energy balance. Our latitudinal transect of cores captures shifts in the position of the Intertropical Convergence Zone (ITCZ) in response to variations in the interhemispheric thermal gradient associated with cooling in Greenland and bipolar seesaw warming in Antarctica. These observations demonstrate that changes in the energy and hydrologic balance of the tropics were repeated features of the penultimate deglaciation, last glacial inception and last glacial cycle, and highlight the role of the tropical atmosphere as a dynamic and responsive component of Earth's climate system.

  5. The salience network is responsible for switching between the default mode network and the central executive network: replication from DCM.

    Science.gov (United States)

    Goulden, Nia; Khusnulina, Aygul; Davis, Nicholas J; Bracewell, Robert M; Bokde, Arun L; McNulty, Jonathan P; Mullins, Paul G

    2014-10-01

    With the advent of new analysis methods in neuroimaging that involve independent component analysis (ICA) and dynamic causal modelling (DCM), investigations have focused on measuring both the activity and connectivity of specific brain networks. In this study we combined DCM with spatial ICA to investigate network switching in the brain. Using time courses determined by ICA in our dynamic causal models, we focused on the dynamics of switching between the default mode network (DMN), the network which is active when the brain is not engaging in a specific task, and the central executive network (CEN), which is active when the brain is engaging in a task requiring attention. Previous work using Granger causality methods has shown that regions of the brain which respond to the degree of subjective salience of a stimulus, the salience network, are responsible for switching between the DMN and the CEN (Sridharan et al., 2008). In this work we apply DCM to ICA time courses representing these networks in resting state data. In order to test the repeatability of our work we applied this to two independent datasets. This work confirms that the salience network drives the switching between default mode and central executive networks and that our novel technique is repeatable.

  6. Hyperthermic responses to central injections of some peptide and non-peptide opioids in the guinea-pig

    Science.gov (United States)

    Kandasamy, S. B.; Williams, B. A.

    1983-01-01

    The intracerebroventricular administration of prototype nonpeptide opioid receptor (mu, kappa, and sigma) agonists, morphine, ketocyclazocine, and N-allyl normetazocine and an agonist at both kappa and sigma receptors, pentazocine, was found to induce hyperthermia in guinea pigs. The similar administration of peptide opioids like beta endorphin, methionine endkephalin, leucine endkephaline, and several of their synthetic analogues was also found to cause hyperthermia. Only the liver-like transport system of the three anion transport systems (iodide, hippurate, and liver-like) present in the choroid plexus was determined to be important to the central inactivation of beta-endorphin and two synthetic analogues. Prostaglandins and norepinephrine (NE) as well as cAMP were not involved in peptide and nonpeptide opioid-induced hyperthermia. Naloxone-sensitive receptors were found to be involved in the induction of hyperthermia by morphine and beta-endorphin, while hyperthermic responses to ketocyclazocine, N-allyl normetazocine, pentazocine, Met-enkephalin, Leu-enkephalin, and two of the synthetic analogues were not antagonized by nalozone. The lack of antagonism of naloxone on pyrogen, arachidonic acid, PGE2, dibutyryl cAMP, and NE-induced hyperthermia shows that endogenous opioid peptides are not likely to be central mediators of the hyperthermia induced by these agents.

  7. Gastric electrical stimulation decreases gastric distension-induced central nociception response through direct action on primary afferents.

    Directory of Open Access Journals (Sweden)

    Wassila Ouelaa

    Full Text Available BACKGROUND & AIMS: Gastric electrical stimulation (GES is an effective therapy to treat patients with chronic dyspepsia refractory to medical management. However, its mechanisms of action remain poorly understood. METHODS: Gastric pain was induced by performing gastric distension (GD in anesthetized rats. Pain response was monitored by measuring the pseudo-affective reflex (e.g., blood pressure variation, while neuronal activation was determined using c-fos immunochemistry in the central nervous system. Involvement of primary afferents was assessed by measuring phosphorylation of ERK1/2 in dorsal root ganglia. RESULTS: GES decreased blood pressure variation induced by GD, and prevented GD-induced neuronal activation in the dorsal horn of the spinal cord (T9-T10, the nucleus of the solitary tract and in CRF neurons of the hypothalamic paraventricular nucleus. This effect remained unaltered within the spinal cord when sectioning the medulla at the T5 level. Furthermore, GES prevented GD-induced phosphorylation of ERK1/2 in dorsal root ganglia. CONCLUSIONS: GES decreases GD-induced pain and/or discomfort likely through a direct modulation of gastric spinal afferents reducing central processing of visceral nociception.

  8. Together with the farmers: social and rural medicine in Japan.

    Science.gov (United States)

    Abrams, H K

    1978-01-01

    Japan emerged from feudalism a century ago. Farmers comprise 20 percent of the population of 110 million. The agricultural cooperative movement sponsors 118 hospitals in rural areas. Of these, the Saku Central Hospital is the largest, and provides leadership to a vigorous rural health movement. Its unique outreach program and its contributions to rural health are described, together with remarks about Japan's health situation generally. There may be lessons here for America.

  9. Rural Old-age Nursing Risk Response:The Experience Learning from Japan%农村养老护理风险应对:日本的经验与借鉴

    Institute of Scientific and Technical Information of China (English)

    夏支平

    2014-01-01

    At present, the problems of old-age nursing risk in rural China have become the public issues which need social re-sponse. After the World War Ⅱ, Japan has accumulated valuable experience in dealing with the rural old-age nursing risk. Experi-ence learning from Japan, these measures should be taken: cherishing the opportunity to develop the rural social security system steadily;strengthening legal protection in order to improve farmers’ stable expectations;county governments oriented and farmers’ families as the core to create an integrated organization system composed of the county governments, township governments and vil-lage for the old-age nursing risk response;overall planning for town and country to increase resources support for the rural old-age nursing risk response.%当前中国农村养老护理风险问题已经成为具有普遍性的,需要社会共同应对的公共问题。二战后的日本在应对农村养老护理风险方面积累了宝贵经验。借鉴这些经验,应该做到珍惜机遇,稳步发展农村社会保障事业;强化法制保障,提高农民的稳定预期;以县为主导,以农户家庭为核心,创建县乡村一体化的养老风险应对组织体系;加大城乡统筹力度,为应对农村养老护理风险提供资源支持。

  10. Coral microbial community dynamics in response to anthropogenic impacts near a major city in the central Red Sea

    KAUST Repository

    Ziegler, Maren

    2016-01-04

    Coral-associated bacteria play an increasingly recognized part in coral health. We investigated the effect of local anthropogenic impacts on coral microbial communities on reefs near Jeddah, the largest city on the Saudi Arabian coast of the central Red Sea. We analyzed the bacterial community structure of water and corals (Pocillopora verrucosa and Acropora hemprichii) at sites that were relatively unimpacted, exposed to sedimentation & local sewage, or in the discharge area of municipal wastewaters. Coral microbial communities were significantly different at impacted sites: in both corals the main symbiotic taxon decreased in abundance. In contrast, opportunistic bacterial families, such as e.g. Vibrionaceae and Rhodobacteraceae, were more abundant in corals at impacted sites. In conclusion, microbial community response revealed a measurable footprint of anthropogenic impacts to coral ecosystems close to Jeddah, even though the corals appeared visually healthy.

  11. Multi-response optimization of factors affecting ultrasonic assisted extraction from Iranian basil using central composite design.

    Science.gov (United States)

    Izadiyan, Parisa; Hemmateenejad, Bahram

    2016-01-01

    The present study reports on the extraction of antioxidant compounds from Iranian Ocimum basilicum. Central composite design (CCD) was used to investigate the effect of extraction variables on the ultrasound-assisted extraction (UAE). Three independent variables including temperature, methanol to water ratio percent, and sonication time were studied for simultaneous optimization of antioxidant capacity, total phenolic content and extraction yield. Both quantitative modeling and response surface methodology suggested that methanol to water ratio percent and extraction temperature were the most effective parameters of UAE process. However, sonication time was found out to be an insignificant factor in ultrasound-assisted extraction of antioxidant and total phenolic compounds of O. basilicum. The optimum conditions were determined as temperature of 59 °C, methanol to water ratio of 65.2% (v/v), and extraction time of 20 min.

  12. Hemodynamic and ADH responses to central blood volume shifts in cardiac-denervated humans

    Science.gov (United States)

    Convertino, V. A.; Thompson, C. A.; Benjamin, B. A.; Keil, L. C.; Savin, W. M.; Gordon, E. P.; Haskell, W. L.; Schroeder, J. S.; Sandler, H.

    1990-01-01

    Hemodynamic responses and antidiuretic hormone (ADH) were measured during body position changes designed to induce blood volume shifts in ten cardiac transplant recipients to assess the contribution of cardiac and vascular volume receptors in the control of ADH secretion. Each subject underwent 15 min of a control period in the seated posture, then assumed a lying posture for 30 min at 6 deg head down tilt (HDT) followed by 20 min of seated recovery. Venous blood samples and cardiac dimensions (echocardiography) were taken at 0 and 15 min before HDT, 5, 15, and 30 min of HDT, and 5, 15, and 30 min of seated recovery. Blood samples were analyzed for hematocrit, plasma osmolality, plasma renin activity (PRA), and ADH. Resting plasma volume (PV) was measured by Evans blue dye and percent changes in PV during posture changes were calculated from changes in hematocrit. Heart rate (HR) and blood pressure (BP) were recorded every 2 min. Results indicate that cardiac volume receptors are not the only mechanism for the control of ADH release during acute blood volume shifts in man.

  13. The U.S. - Japan Security Alliance: Will it Survive in the New World Order?

    Science.gov (United States)

    1991-04-01

    further solidified Japan’s perception of the Soviets as a military threat. Now, warming of U.S.-Soviet relations also could change Japan’s traditional view...fierce debate internally, Japan c;F’e under increasing pressure from abroad-- some criticizing her ck of response, some urging her to exert a globa L role

  14. Malnutrition alters the cardiovascular responses induced by central injection of tityustoxin in Fischer rats.

    Science.gov (United States)

    Silva, Fernanda Cacilda Santos; Guidine, Patrícia Alves; Ribeiro, Mara Fernandes; Fernandes, Luciano Gonçalves; Xavier, Carlos Henrique; de Menezes, Rodrigo Cunha; Silva, Marcelo Eustáquio; Moraes-Santos, Tasso; Moraes, Márcio Flávio; Chianca, Deoclécio Alves

    2013-12-15

    Scorpion envenoming and malnutrition are considered two important public health problems in Brazil, involving mainly children. Both these conditions are more common among the economically stratified lower income portion of the population, thus suggesting that these factors should be analyzed concomitantly. It is known that cardiorespiratory manifestations, as cardiac arrhythmias, arterial hypertension and hypotension, pulmonary edema and circulatory failure are the main "causa mortis" of scorpion envenomation. Additionally, there are evidences in the literature that deficiencies in dietary intake endanger the CNS and modify the cardiovascular homeostasis. Then, the objective of this work is to evaluate the protein malnourished effect on cardiovascular responses induced by tityustoxin (TsTX, an α-type toxin extracted from the Tityus serrulatus scorpion venom). Fischer rats (n = 20) were injected i.c.v. with TsTX and divided in control and malnorished groups, which were, respectively, submitted to a control and a low-protein diet. Arterial pressure recordings were done until death of the animals. Although both groups presented an increased mean arterial pressure after TsTX injection, this increase was smaller and delayed in malnourished rats, when compared to control rats. In addition, heart rate increased only in rats from the control group. Finally, malnourished rats had an increase in survival time (9:9/13.5 vs. 15.5:10.5/18 min; p = 0.0009). In summary, our results suggest that the protein restriction attenuates the cardiovascular manifestations resulting from TsTX action on CNS.

  15. Responses of a tall building with U.S. code-type instrumentation in Tokyo, Japan, to events before, during and after the Tohoku earthquake of 11 March 2011

    Science.gov (United States)

    Çelebi, Mehmet; Kashima, Toshihide; Ghahari, S. Farid; Abazarsa, Fariba; Taciroglu, Ertugrul

    2016-01-01

    The 11 March 2011 M 9.0 Tohoku earthquake generated long-duration shaking that propagated hundreds of kilometers from the epicenter and affected tall buildings in urban areas several hundred kilometers from the epicenter of the main shock. Recorded responses show that tall buildings were affected by long-period motions. This study presents the behavior and performance of a 37-story building in the Tsukuda area of Tokyo, Japan, as inferred from modal analyses of records retrieved for a time interval covering a few days before, during, and for several months after the main shock. The U.S. “code-type” array comprises three triaxial accelerometers deployed at three levels in the superstructure. Such a sparse array in a tall structure limits a reliable assessment, because its performance must be based on only the average drift ratios. Based on the inferred values of this parameter, the subject building was not structurally damaged.

  16. The emperor of Japan and the aurora

    Science.gov (United States)

    Akasofu, S. I.

    On October 3, 1985, I gave a special lecture on the aurora for the Emperor of Japan in his palace in Tokyo. It seems the Emperor, a marine biologist, has an unusual interest in the aurora. After my slide presentation, he asked how we confirm ancient sighting reports of the aurora in Japan. He was not satisfied with my response that anomalous events in the sky were well documented in an ancient publication entitled Japanese Meteorological Data and asked further how one could confirm such sightings as auroral events. He was visibly pleased to learn that the dates of these sightings coincided with those recorded elsewhere in the world.

  17. Changes in gene expression of Actinobacillus pleuropneumoniae in response to anaerobic stress reveal induction of central metabolism and biofilm formation.

    Science.gov (United States)

    Li, Lu; Zhu, Jiawen; Yang, Kui; Xu, Zhuofei; Liu, Ziduo; Zhou, Rui

    2014-06-01

    Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry worldwide. Oxygen deprivation is a stress that A. pleuropneumoniae will encounter during both early infection and the later, persistent stage. To understand modulation of A. pleuropneumoniae gene expression in response to the stress caused by anaerobic conditions, gene expression profiles under anaerobic and aerobic conditions were compared in this study. The microarray results showed that 631 genes (27.7% of the total ORFs) were differentially expressed in anaerobic conditions. Many genes encoding proteins involved in glycolysis, carbon source uptake systems, pyruvate metabolism, fermentation and the electron respiration transport chain were up-regulated. These changes led to an increased amount of pyruvate, lactate, ethanol and acetate in the bacterial cells as confirmed by metabolite detection. Genes encoding proteins involved in cell surface structures, especially biofilm formation, peptidoglycan biosynthesis and lipopolysaccharide biosynthesis were up-regulated as well. Biofilm formation was significantly enhanced under anaerobic conditions. These results indicate that induction of central metabolism is important for basic survival of A. pleuropneumoniae after a shift to an anaerobic environment. Enhanced biofilm formation may contribute to the persistence of this pathogen in the damaged anaerobic host tissue and also in the early colonization stage. These discoveries give new insights into adaptation mechanisms of A. pleuropneumoniae in response to environmental stress.

  18. Application of Response Surface Methodology and Central Composite Inscribed Design for Modeling and Optimization of Marble Surface Quality

    Directory of Open Access Journals (Sweden)

    Sümeyra Cevheroğlu Çıra

    2016-01-01

    Full Text Available Factors affecting the final surface quality of polished marble are not yet fully understood. Clarifying these factors for optimization of multivariate polishing process by trial and error method is difficult, time-consuming, and costly task. In this study, the empirical practices were carried out using an experimental design, specifically, a central composite inscribed (CCI design. The factors considered in CCI design were belt speed, rotational speed, and pressure of the polishing head, and the responses were surface glossiness and roughness. Mathematical models describing responses were produced using experimental datasets, and analysis of variance (ANOVA was used to assess the fit of the models generated with the experimental data. For process optimization, desirability function analysis (DFA was used. This study has shown that the CCI could efficiently be applied for the modelling of polishing machine for surface quality of marble strips. Better surface quality generally resulted from lower belt speeds, which increased contact time between the abrasives and strips. Optimized surface quality for marble specimen was established.

  19. Vegetation Dynamics and Its Response to Climate Change - A Case Study from Gandaki River Basin in Central Nepal

    Science.gov (United States)

    Panthi, J., Sr.

    2016-12-01

    Vegetation is affected by inter-annual variability and trends in precipitation, temperature, and snow cover. Remote sensing is especially important for monitoring vegetation response in mountainous regions like the Himalayas in subtropical Asia, where few detailed field investigations of ecosystem variability have been performed due to logistical challenges. We compared MODIS Normalized Difference Vegetation Index (NDVI) in the Gandaki River Basin (GRB) in central Nepal to mean climate and its interannual variability and trends to quantify these relationships over a steep elevation gradient. NDVI was found to be highest in the lower and middle elevations and sharply decrease past 3000 m asl. Seasonally, NDVI peaks in the fall (post-monsoon season) followed by summer (monsoon season), indicating a positive response of vegetation to the rainfall peak. Inter-annual variability in climate, particularly temperature, is correlated with NDVI fluctuations in the basin. When the GRB is disaggregated by land cover, NDVI is most closely related to temperature and precipitation in agricultural areas, followed by grasslands. Snow cover in the GRB is decreasing but does not show any relationship with basin-wide NDVI.

  20. Regulatory approval pathways for anticancer drugs in Japan, the EU and the US.

    Science.gov (United States)

    Nagai, Sumimasa; Ozawa, Keiya

    2016-07-01

    The Pharmaceuticals and Medical Devices Agency and the Ministry of Health, Labour and Welfare in Japan and the US Food and Drug Administration are responsible for reviewing applications and approving drugs, medical devices, and regenerative medicines. In the EU, the European Medicines Agency is responsible for the centralized authorization procedure of medicines including oncologic drugs. In this review, we discuss general pathways for the marketing authorization of oncologic drugs and other drugs in Japan, the EU, and the US. There are still unmet medical needs in oncology, whereas scientific innovation and clinical development in oncology are rapid and active, suggesting a reasonable scope for new regulatory schemes for expedited review. Because regulatory schemes are also evolving rapidly, clinicians and academic researchers may have difficulty following the updated regulations in other regions as well as those in their own countries. However, keeping current with new regulations is important for the conduct of translational research and clinical development of new therapeutic products efficiently. This review is intended to help an international audience better understand the essence of the regulatory frameworks for the marketing authorization of oncologic drugs in Japan, the EU, and the US.

  1. Japan steel mill perspective

    Energy Technology Data Exchange (ETDEWEB)

    Murase, K. [Kobe Steel Ltd., Tokyo (Japan)

    2004-07-01

    The international and Japan's steel industry, the coking coal market, and Japan's expectations from Canada's coal industry are discussed. Japan's steel mills are operating at full capacity. Crude steel production for the first half of 2004 was 55.8 million tons. The steel mills are profitable, but costs are high, and there are difficulties with procuring raw materials. Japan is trying to enhance the quality of coke, in order to achieve higher productivity in the production of pig iron. Economic growth is rising disproportionately in the BRICs (Brazil, Russia, India, and China), with a large increase in coking coal demand from China. On the supply side, there are several projects underway in Australia and Canada to increase production. These include new developments by Elk Valley Coal Corporation, Grande Cache Coal, Western Canadian Coal, and Northern Energy and Mining in Canada. The Elga Mine in the far eastern part of Russia is under development. But the market is expected to remain tight for some time. Japan envisions Canadian coal producers will provide a stable coal supply, expansion of production and infrastructure capabilities, and stabilization of price. 16 slides/overheads are included.

  2. Twenty years of ecosystem response after clearcutting and slashburning in conifer forests of central British Columbia, Canada

    Science.gov (United States)

    Feller, Michael; Bradfield, Gary

    2017-01-01

    Forests are being clearcut over extensive areas of western North America, but plant community response to harvesting and slashburning under varying climatic conditions in central British Columbia, Canada is still largely unknown. Evaluation of resilience is hampered by the short history of logging, lack of long-term experiments and methodological limitations. To test the effect of clearcut logging, prescribed burning and reforestation on forest resilience, we recorded vascular plant cover repeatedly after treatment between 1981 and 2008 in 16 permanent research installations in three biogeoclimatic zones: Engelmann Spruce-Subalpine Fir, Interior Cedar-Hemlock and Sub-Boreal Spruce. We created a plant-trait dataset for the 181 recorded species to define plant functional types representing groups of plants that behave in similar ways and/or produce similar ecological outcomes. These plant functional types, along with taxonomic analysis of diagnostic and indicator species, were then used to evaluate plant community response to disturbance. Twenty years post-treatment, species diversity increased in all zones and plant abundance was greatest in the Interior Cedar-Hemlock. Cover of understory plant functional types associated with mature conifer forests increased in all zones, constituting a significant proportion (> 40%) of the vegetation community by year 20. Response patterns varied by zone and with time. Understory species diagnostic of mature forests were present in all zones by year 20, but we identified indicator species sensitive to slashburning or requiring more time for recovery, including white-flowered rhododendron (Rhododendron albiflorum) and devil's club (Oplopanax horridus). Overall, loss of compositional or functional diversity following harvest and site remediation was not detected, suggesting that montane and subalpine forests in British Columbia are resilient to this treatment. However, because these forests can be slow to recover from disturbance

  3. The redox-sensing regulator Rex modulates central carbon metabolism, stress tolerance response and biofilm formation by Streptococcus mutans.

    Directory of Open Access Journals (Sweden)

    Jacob P Bitoun

    Full Text Available The Rex repressor has been implicated in regulation of central carbon and energy metabolism in gram-positive bacteria. We have previously shown that Streptococcus mutans, the primary causative agent of dental caries, alters its transcriptome upon Rex-deficiency and renders S. mutans to have increased susceptibility to oxidative stress, aberrations in glucan production, and poor biofilm formation. In this study, we showed that rex in S. mutans is co-transcribed as an operon with downstream guaA, encoding a putative glutamine amidotransferase. Electrophoretic mobility shift assays showed that recombinant Rex bound promoters of target genes avidly and specifically, including those down-regulated in response to Rex-deficiency, and that the ability of recombinant Rex to bind to selected promoters was modulated by NADH and NAD(+. Results suggest that Rex in S. mutans can function as an activator in response to intracellular NADH/NAD(+ level, although the exact binding site for activator Rex remains unclear. Consistent with a role in oxidative stress tolerance, hydrogen peroxide challenge assays showed that the Rex-deficient mutant, TW239, and the Rex/GuaA double mutant, JB314, were more susceptible to hydrogen peroxide killing than the wildtype, UA159. Relative to UA159, JB314 displayed major defects in biofilm formation, with a decrease of more than 50-fold in biomass after 48-hours. Collectively, these results further suggest that Rex in S. mutans regulates fermentation pathways, oxidative stress tolerance, and biofilm formation in response to intracellular NADH/NAD(+ level. Current effort is being directed to further investigation of the role of GuaA in S. mutans cellular physiology.

  4. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration.

    Science.gov (United States)

    Whitaker, Keith W; Reyes, Teresa M

    2008-03-01

    Loss of appetite and cachexia is an obstacle in the treatment of chronic infection and cancer. Proinflammatory cytokines released from activated immune cells and acting in the central nervous system (CNS) are prime candidates for mediating these metabolic changes, potentially affecting both energy intake as well as energy expenditure. The effect of intravenous administration of two proinflammatory cytokines, interleukin (IL)-1beta (15 microg/kg) and tumor necrosis factor (TNF)-alpha (10 microg/kg), on food and water intake, locomotor activity, oxygen consumption (VO2), and respiratory exchange ratio (RER) was evaluated. The two cytokines elicited a comparable decrease in food intake and activated similar numbers of cells in the paraventricular nucleus of the hypothalamus (PVH), a region that plays a critical role in the regulation of appetite and metabolism (determined via expression of the immediate early gene, c-fos). However, only IL-1beta reduced locomotion and RER, and increased VO2, while TNF-alpha was without effect. To examine the role of the melanocortins in mediating IL-1beta- induced metabolic changes, animals were pretreated centrally with a melanocortin receptor antagonist, HS014. Pretreatment with HS014 blocked the effect of IL-1beta on food intake and RER at later time points (beyond 8 h post injection), as well as the hypoactivity and increased metabolic rate. Further, HS014 blocked the induction of Fos-ir in the PVH. These data highlight the importance of the melanocortin system, particularly within the PVH, in mediating a broad range of metabolic responses to IL-1beta.

  5. Psychology in Japan.

    Science.gov (United States)

    Imada, Hiroshi; Tanaka-Matsumi, Junko

    2016-06-01

    The purpose of this article is to provide information about Japan and its psychology in advance of the 31st International Congress of Psychology (ICP), to be held in Yokohama, Japan, in 2016. The article begins with the introduction of the Japanese Psychological Association (JPA), the hosting organization of the ICP 2016, and the Japanese Union of Psychological Associations consisting of 51 associations/societies, of which the JPA is a member. This is followed by a brief description of a history of psychology of Japan, with emphasis on the variation in our approach to psychology in three different periods, that is, the pre- and post-Pacific War periods, and the post-1960 period. Next, the international contributions of Japanese psychology/psychologists are discussed from the point of view of their visibility. Education and training in psychology in Japanese universities is discussed with a final positive remark about the long-awaited enactment of the Accredited Psychologist Law in September, 2015.

  6. Cultural Astronomy in Japan

    Science.gov (United States)

    Renshaw, Steven L.

    While Japan is known more for its contributions to modern astronomy than its archaeoastronomical sites, there is still much about the culture's heritage that is of interest in the study of cultural astronomy. This case study provides an overview of historical considerations necessary to understand the place of astronomy in Japanese society as well as methodological considerations that highlight traditional approaches that have at times been a barrier to interdisciplinary research. Some specific areas of study in the cultural astronomy of Japan are discussed including examples of contemporary research based on interdisciplinary approaches. Japan provides a fascinating background for scholars who are willing to go beyond their curiosity for sites of alignment and approach the culture with a desire to place astronomical iconography in social context.

  7. The Japan Medical Association's disaster preparedness: lessons from the Great East Japan Earthquake and Tsunami.

    Science.gov (United States)

    Ishii, Masami; Nagata, Takashi

    2013-10-01

    A complex disaster, the Great East Japan Earthquake of March 11, 2011, consisted of a large-scale earthquake, tsunami, and nuclear accident, resulting in more than 15 000 fatalities, injuries, and missing persons and damage over a 500-km area. The entire Japanese public was profoundly affected by "3/11." The risk of radiation exposure initially delayed the medical response, prolonging the recovery efforts. Japan's representative medical organization, the Japan Medical Association (JMA), began dispatching Japan Medical Association Teams (JMATs) to affected areas beginning March 15, 2011. About 1400 JMATs comprising nearly 5500 health workers were launched. The JMA coordinated JMAT operations and cooperated in conducting postmortem examination, transporting large quantities of medical supplies, and establishing a multiorganizational council to provide health assistance to disaster survivors. Importantly, these response efforts contributed to the complete recovery of the health care system in affected areas within 3 months, and by July 15, 2011, JMATs were withdrawn. Subsequently, JMATs II have been providing long-term continuing medical support to disaster-affected areas. However, Japan is at great risk for future natural disasters because of its Pacific Rim location. Also, its rapidly aging population, uneven distribution of and shortage of medical resources in regional communities, and an overburdened public health insurance system highlight the need for a highly prepared and effective disaster response system.

  8. Sub Moho boundary beneath island arc, Japan

    Science.gov (United States)

    Iidaka, T.; Igarashi, T.; Lee, C.; Iwasaki, T.; Niu, F.

    2008-12-01

    Moho is a seismic boundary discovered by Mohorovicic in 1909. It is generally considered as the boundary between Earth"fs crust and mantle, although the origin of the Moho and the definition of the crust-mantle boundary are still debated. Regardless whether it represents a phase or chemical boundary, it has been investigated world wide by seismologists since its discovery. Reflection/refraction data acquired from active sources were the main sources of the investigation. Recently, receiver function analysis provided an emerging tool for mapping this boundary below a seismic station. Since reflection/refraction data sample P- wave structure while receiver-function data are basically sensitive to S-wave velocity, a comparison of the two can provide better constraints on the composition of the lowermost crust and the uppermost mantle. In this study, we used receiver function data to determine subsurface boundaries. Receiver functions are calculated from teleseismic records of a borehole seismic network in Japan, the Hi-net, which covers the entire Japan with a 20-km station spacing. We used the multi-taper deconvolution method to generate individual receiver functions and a common-conversion-point gathering method for stacking the receiver functions. Results along several profiles where seismic refraction surveys have been conducted in the past were selected for comparison. We found remarkable difference between southwestern and central/northeastern Japan. In southwestern Japan both receiver function and refraction data yield a consistent and distinct Moho at around 35 km. In central and northeastern Japan, however, receiver function images reveal two P-to-S conversion events at approximately 30 km and 40 km, respectively. The shallow 30-km deep boundary is consistent with the refraction Moho. The deep boundary (sub-Moho) is about 10 km deeper than the refraction Moho boundary. The uppermost mantle seismic structure at central and northeastern Japan was known to be

  9. Divorce in contemporary Japan.

    Science.gov (United States)

    Fukurai, H; Alston, J

    1990-10-01

    Data from the 1985-86 Japanese census are analysed to explore the determinants of the divorce rates in Japan's forty-seven prefectures, using two theoretical models: (a) the social integration model, which is shown to have a greater utility in predicting Japanese divorce levels than (b), the human capital model. Female emigration patterns play a significant role in affecting the divorce rate. Population increase and net household income are also important predictors of the Japanese divorce rate and urbanization has a great influence in modern Japan. Demographic and aggregate variables such as migration, urbanization, and socioeconomic factors are useful when organized under a social integration model.

  10. Central effect of histamine and peripheral effect of histidine on the formalin-induced pain response in mice.

    Science.gov (United States)

    Tamaddonfard, Esmaeal; Rahimi, Saead

    2004-08-01

    /mouse, i.c.v., histamine strongly suppressed both phases of the formalin-induced pain response, particularly the second phase. 8. The results of the present study indicate that: (i) activation of brain histamine produces antinociception in the mouse formalin test; (ii) peripheral loading with a high dose of histidine (1000 mg/kg, i.p.) alone exerts the same effect as that seen following 40 microg/mouse, i.c.v., histamine; and (iii) pretreatment with a high dose of histidine potentiates central histamine-induced antinociception.

  11. Social Mobilization and Community Engagement Central to the Ebola Response in West Africa: Lessons for Future Public Health Emergencies.

    Science.gov (United States)

    Gillespie, Amaya M; Obregon, Rafael; El Asawi, Rania; Richey, Catherine; Manoncourt, Erma; Joshi, Kshiitij; Naqvi, Savita; Pouye, Ade; Safi, Naqibullah; Chitnis, Ketan; Quereshi, Sabeeha

    2016-12-23

    Following the World Health Organization (WHO) declaration of a Public Health Emergency of International Concern regarding the Ebola outbreak in West Africa in July 2014, UNICEF was asked to co-lead, in coordination with WHO and the ministries of health of affected countries, the communication and social mobilization component-which UNICEF refers to as communication for development (C4D)-of the Ebola response. For the first time in an emergency setting, C4D was formally incorporated into each country's national response, alongside more typical components such as supplies and logistics, surveillance, and clinical care. This article describes the lessons learned about social mobilization and community engagement in the emergency response to the Ebola outbreak, with a particular focus on UNICEF's C4D work in Guinea, Liberia, and Sierra Leone. The lessons emerged through an assessment conducted by UNICEF using 4 methods: a literature review of key documents, meeting reports, and other articles; structured discussions conducted in June 2015 and October 2015 with UNICEF and civil society experts; an electronic survey, launched in October and November 2015, with staff from government, the UN, or any partner organization who worked on Ebola (N = 53); and key informant interviews (N = 5). After triangulating the findings from all data sources, we distilled lessons under 7 major domains: (1) strategy and decentralization: develop a comprehensive C4D strategy with communities at the center and decentralized programming to facilitate flexibility and adaptation to the local context; (2) coordination: establish C4D leadership with the necessary authority to coordinate between partners and enforce use of standard operating procedures as a central coordination and quality assurance tool; (3) entering and engaging communities: invest in key communication channels (such as radio) and trusted local community members; (4) messaging: adapt messages and strategies continually as patterns

  12. Globalization and Education in Japan

    Science.gov (United States)

    Ohkura, Kentaro; Shibata, Masako

    2009-01-01

    In this paper, the authors contend that globalization in Japan is the gradual process in which Japan's positioning of "self" within international relations, which had formerly been dominated by the West, has changed. Accordingly, Japan's relationships with the West and the rest of the world, for example, Asia, have also been reviewed and…

  13. Globalization and Education in Japan

    Science.gov (United States)

    Ohkura, Kentaro; Shibata, Masako

    2009-01-01

    In this paper, the authors contend that globalization in Japan is the gradual process in which Japan's positioning of "self" within international relations, which had formerly been dominated by the West, has changed. Accordingly, Japan's relationships with the West and the rest of the world, for example, Asia, have also been reviewed and…

  14. Exposure-response relationship of wind turbine noise with self-reported symptoms of sleep and health problems: A nationwide socioacoustic survey in Japan.

    Science.gov (United States)

    Kageyama, Takayuki; Yano, Takashi; Kuwano, Sonoko; Sueoka, Shinichi; Tachibana, Hideki

    2016-01-01

    The association of wind turbine noise (WTN) with sleep and physical/mental health has not been fully investigated. To investigate the relationship of WTN with the prevalence of self-reported symptoms of sleep and health problems, a socioacoustic survey of 1079 adult residents was conducted throughout Japan (2010-2012): 747 in 34 areas surrounding wind turbine plants and 332 in 16 control areas. During face-to-face interviews, the respondents were not informed of the purpose of the survey. Questions on symptoms such as sleeplessness and physical/mental complaints were asked without specifying reasons. Insomnia was defined as having one or any combination of the following that occurs three or more times a week and bothers a respondent: Difficulty initiating sleep, difficulty maintaining sleep, premature morning awakening, and feeling of light overnight sleep. Poor health was defined as having high scores for health complaints, as determined using the Total Health Index, exceeding the criteria proposed by the authors of the index. The noise descriptor for WTN was LAeq,n outdoor, estimated from the results of actual measurement at some locations in each site. Multiple logistic analysis was applied to the LAeq,n and insomnia or poor health. The odds ratio (OR) of insomnia was significantly higher when the noise exposure level exceeded 40 dB, whereas the self-reported sensitivity to noise and visual annoyance with wind turbines were also independently associated with insomnia. OR of poor health was not significant for noise exposure, but significant for noise sensitivity and visual annoyance. The above two moderators appear to indicate the features of respondents who are sensitive to stimuli or changes in their homeostasis.

  15. Exposure-response relationship of wind turbine noise with self-reported symptoms of sleep and health problems: A nationwide socioacoustic survey in Japan

    Directory of Open Access Journals (Sweden)

    Takayuki Kageyama

    2016-01-01

    Full Text Available The association of wind turbine noise (WTN with sleep and physical/mental health has not been fully investigated. To investigate the relationship of WTN with the prevalence of self-reported symptoms of sleep and health problems, a socioacoustic survey of 1079 adult residents was conducted throughout Japan (2010-2012: 747 in 34 areas surrounding wind turbine plants and 332 in 16 control areas. During face-to-face interviews, the respondents were not informed of the purpose of the survey. Questions on symptoms such as sleeplessness and physical/mental complaints were asked without specifying reasons. Insomnia was defined as having one or any combination of the following that occurs three or more times a week and bothers a respondent: Difficulty initiating sleep, difficulty maintaining sleep, premature morning awakening, and feeling of light overnight sleep. Poor health was defined as having high scores for health complaints, as determined using the Total Health Index, exceeding the criteria proposed by the authors of the index. The noise descriptor for WTN was LAeq,n outdoor, estimated from the results of actual measurement at some locations in each site. Multiple logistic analysis was applied to the LAeq,n and insomnia or poor health. The odds ratio (OR of insomnia was significantly higher when the noise exposure level exceeded 40 dB, whereas the self-reported sensitivity to noise and visual annoyance with wind turbines were also independently associated with insomnia. OR of poor health was not significant for noise exposure, but significant for noise sensitivity and visual annoyance. The above two moderators appear to indicate the features of respondents who are sensitive to stimuli or changes in their homeostasis.

  16. Role of Serum Brain Derived Neurotrophic Factor and Central N-Acetylaspartate for Clinical Response under Antidepressive Pharmacotherapy

    Directory of Open Access Journals (Sweden)

    Sarah Nase

    2016-02-01

    Full Text Available Background: The predictive therapeutic value of brain derived neurotrophic factor (BDNF and its changes associated with the use of specific antidepressants are still unclear. In this study, we examined BDNF as a peripheral and NAA as a central biomarker over the time course of antidepressant treatment to specify both of their roles in the response to the medication and clinical outcome. Methods: We examined serum BDNF (ELISA kit in a sample of 76 (47 female and 29 male depressed patients in a naturalistic setting. BDNF was assessed before medication and subsequently after two, four and six weeks of antidepressant treatment. Additionally, in fifteen patients, N-acetylaspartate (NAA was measured in the anterior cingulate cortex (ACC with magnetic resonance spectroscopy (MRS. Over a time course of six weeks BDNF and NAA were also examined in a group of 41 healthy controls. Results: We found significant lower serum BDNF concentrations in depressed patients compared to the sample of healthy volunteers before and after medication. BDNF and clinical symptoms decreased significantly in the patients over the time course of antidepressant treatment. Serum BDNF levels at baseline predicted the symptom outcome after eight weeks. Specifically, responders and remitters had lower serum BDNF at baseline than the nonresponders and nonremitters. NAA was slightly decreased but not significantly lower in depressed patients when compared with healthy controls. During treatment period, NAA showed a tendency to increase. Limitations: A relative high drop-out rate and possibly, a suboptimal observation period for BDNF. Conclusion: Our data confirm serum BDNF as a biomarker of depression with a possible role in response prediction. However, our findings argue against serum BDNF increase being a prerequisite to depressive symptom reduction.

  17. SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons

    Science.gov (United States)

    Plant, Leigh D; Marks, Jeremy D; Goldstein, Steve AN

    2016-01-01

    The mechanism for the earliest response of central neurons to hypoxia—an increase in voltage-gated sodium current (INa)—has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases INa. The time-course for SUMOylation of single NaV1.2 channels at the cell surface and changes in INa coincide, and both are prevented by mutation of NaV1.2-Lys38 or application of a deSUMOylating enzyme. Within 40 s, hypoxia-induced linkage of SUMO1 to the channels is complete, shifting the voltage-dependence of channel activation so that depolarizing steps evoke larger sodium currents. Given the recognized role of INa in hypoxic brain damage, the SUMO pathway and NaV1.2 are identified as potential targets for neuroprotective interventions. DOI: http://dx.doi.org/10.7554/eLife.20054.001 PMID:28029095

  18. Blast response of centrally and eccentrically loaded flat-, U-, and V-shaped armored plates: comparative study

    Science.gov (United States)

    Trajkovski, J.; Kunc, R.; Prebil, I.

    2017-07-01

    Light armored vehicles (LAVs) can be exposed to blast loading by landmines or improvised explosive devices (IEDs) during their lifetime. The bottom hull of these vehicles is usually made of a few millimeters of thin armored plate that is the vehicle's weak point in a blast-loading scenario. Therefore, blast resistance and blast load redirection are very important characteristics in providing adequate vehicle as well as occupant protection. Furthermore, the eccentric nature of loading caused by landmines was found to be omitted in the studies of simplified structures like beams and plates. For this purpose, blast wave dispersion and blast response of centrally and eccentrically loaded flat-, U-, and V-shaped plates are examined using a combined finite-element-smoothed-particle hydrodynamics (FE-SPH) model. The results showed that V-shaped plates better disperse blast waves for any type of loading and, therefore, can be successfully applied in LAVs. Based on the results of the study and the geometry of a typical LAV 6× 6, the minimum angle of V-shaped plates is also determined.

  19. Response properties of neurons in the core of the central nucleus of the inferior colliculus of the barn owl.

    Science.gov (United States)

    Wagner, Hermann; Mazer, James A; von Campenhausen, Mark

    2002-04-01

    The central nucleus of the inferior colliculus (ICC) is particularly important for the processing of interaural time differences (ITDs). In the barn owl, neuronal best frequencies in a subnucleus of the ICC, the ICCcore, span the animal's entire hearing range (approximately equal to 200-10 000 Hz). This means that low-frequency ITD-sensitive ICCcore neurons in the owl can be directly compared to ITD-sensitive mammalian ICC neurons with similar best frequencies as well as to the high-frequency ITD-sensitive neurons usually studied in owls. This report represents a first attempt to systematically describe important physiological properties of ICCcore neurons in the barn owl, with particular attention to the low-frequency region (owl's physiological ITD range. ITD tuning widths were inversely correlated with neuronal best frequency. None of the ICCcore neurons studied were sensitive to interaural level differences. Monaural inputs to ICCcore cells were typically binaurally balanced, i.e. they exhibited similar response thresholds, dynamic ranges, slopes and saturation levels, for both left and right ear monaural stimulation.

  20. Blast response of centrally and eccentrically loaded flat-, U-, and V-shaped armored plates: comparative study

    Science.gov (United States)

    Trajkovski, J.; Kunc, R.; Prebil, I.

    2016-12-01

    Light armored vehicles (LAVs) can be exposed to blast loading by landmines or improvised explosive devices (IEDs) during their lifetime. The bottom hull of these vehicles is usually made of a few millimeters of thin armored plate that is the vehicle's weak point in a blast-loading scenario. Therefore, blast resistance and blast load redirection are very important characteristics in providing adequate vehicle as well as occupant protection. Furthermore, the eccentric nature of loading caused by landmines was found to be omitted in the studies of simplified structures like beams and plates. For this purpose, blast wave dispersion and blast response of centrally and eccentrically loaded flat-, U-, and V-shaped plates are examined using a combined finite-element-smoothed-particle hydrodynamics (FE-SPH) model. The results showed that V-shaped plates better disperse blast waves for any type of loading and, therefore, can be successfully applied in LAVs. Based on the results of the study and the geometry of a typical LAV 6× 6 , the minimum angle of V-shaped plates is also determined.

  1. Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design

    Directory of Open Access Journals (Sweden)

    Gurinder Singh

    2012-01-01

    Full Text Available Furosemide is a powerful diuretic and antihypertensive drug which has low bioavailability due to hepatic first pass metabolism and has a short half-life of 2 hours. To overcome the above drawback, the present study was carried out to formulate and evaluate sustained release (SR pellets of furosemide for oral administration prepared by extrusion/spheronization. Drug Coat L-100 was used within the pellet core along with microcrystalline cellulose as the diluent and concentration of selected binder was optimized to be 1.2%. The formulation was prepared with drug to polymer ratio 1:3. It was optimized using Design of Experiments by employing a 3 2 central composite design that was used to systematically optimize the process parameters combined with response surface methodology. Dissolution studies were carried out with USP apparatus Type I (basket type in both simulated gastric and intestinal pH. The statistical technique, i.e., the two-tailed paired t test and one-way ANOVA of in vitro data has proposed that there was very significant ( P≤0.05 difference in dissolution profile of furosemide SR pellets when compared with pure drug and commercial product. Validation of the process optimization study indicated an extremely high degree of prognostic ability. The study effectively undertook the development of optimized process parameters of pelletization of furosemide pellets with tremendous SR characteristics.

  2. Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design.

    Science.gov (United States)

    Singh, Gurinder; Pai, Roopa S; Devi, V Kusum

    2012-01-01

    Furosemide is a powerful diuretic and antihypertensive drug which has low bioavailability due to hepatic first pass metabolism and has a short half-life of 2 hours. To overcome the above drawback, the present study was carried out to formulate and evaluate sustained release (SR) pellets of furosemide for oral administration prepared by extrusion/spheronization. Drug Coat L-100 was used within the pellet core along with microcrystalline cellulose as the diluent and concentration of selected binder was optimized to be 1.2%. The formulation was prepared with drug to polymer ratio 1:3. It was optimized using Design of Experiments by employing a 3(2) central composite design that was used to systematically optimize the process parameters combined with response surface methodology. Dissolution studies were carried out with USP apparatus Type I (basket type) in both simulated gastric and intestinal pH. The statistical technique, i.e., the two-tailed paired t test and one-way ANOVA of in vitro data has proposed that there was very significant (P≤0.05) difference in dissolution profile of furosemide SR pellets when compared with pure drug and commercial product. Validation of the process optimization study indicated an extremely high degree of prognostic ability. The study effectively undertook the development of optimized process parameters of pelletization of furosemide pellets with tremendous SR characteristics.

  3. Migrants and asylum seekers: policy responses in the United States to immigrants and refugees from Central America and the Caribbean.

    Science.gov (United States)

    Mcbride, M J

    1999-01-01

    This article analyzes the complex political environment of US immigration and refugee policies in which tensions exist, especially with regard to Central America and the Caribbean. Recommendations for managing it more effectively in the future are discussed. Several western countries, including the US, have implemented stricter restriction policies as a result of the perceived threats to their economies and cultural homogeneity. In general, US immigration policy has addressed both economic concerns and domestic pressures, whereas US refugee policy has reflected foreign policy concerns. As a result of these policies, there has been an increasing number of immigrants from Mexico, as well as huge numbers of refugees from Cuba and Nicaragua. Yet, there has been limited acceptance of asylum seekers from Haiti, El Salvador and Guatemala. Among the policies passed by the US Congress to reduce illegal immigration and limit assistance to legal immigrants were the Welfare Reform Act, Illegal Immigration Reform, Immigration Responsibility Act of 1996, and the Proposition 187 movement. Revisions in the procedures of the Immigration and Naturalization Service were also made.

  4. Sapovirus in Water, Japan

    Science.gov (United States)

    Sano, Daisuke; Ueki, You; Imai, Takahiro; Oka, Tomoichiro; Katayama, Kazuhiko; Takeda, Naokazu; Omura, Tatsuo

    2007-01-01

    Sapoviruses are etiologic agents of human gastroenteritis. We detected sapovirus in untreated wastewater, treated wastewater, and a river in Japan. A total of 7 of 69 water samples were positive by reverse transcription–PCR. Phylogenetic analysis of the viral capsid gene grouped these strains into 4 genetic clusters. PMID:17370528

  5. Globalization in Japan

    DEFF Research Database (Denmark)

    Roesgaard, Marie Højlund

    2014-01-01

    Abstract for Nichibunken Copenhagen Symposium August 2012 Globalization in Japan – the case of moral education. 日本とグローバル化 - 道徳教育の件 Marie H. Roesgaard, Department of Cross-Cultural and Regional Studies, University of Copenhagen. This paper attempts to trace the history of global influence on Japan......Abstract for Nichibunken Copenhagen Symposium August 2012 Globalization in Japan – the case of moral education. 日本とグローバル化 - 道徳教育の件 Marie H. Roesgaard, Department of Cross-Cultural and Regional Studies, University of Copenhagen. This paper attempts to trace the history of global influence...... adjusting to those of the global currents that cannot be ignored. Further, I would suggest that global, or at least Western, influence is not a new thing in regard to moral education in Japan. The paper will provide an historical overview of the development of moral education since Meiji times and focus...

  6. 1993 Hokkaido, Japan Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — On July 12, 1993, a magnitude 7.6 Ms (7.7 Mw) (HRV) earthquake at 13:17 UT in the Sea of Japan near Hokkaido caused a back-arc tsunami that caused damage in all of...

  7. Liquid hydrogen in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Yasumi, S. [Iwatani Corp., Osaka (Japan). Dept. of Overseas Business Development

    2009-07-01

    Japan's Iwatani Corporation has focused its attention on hydrogen as the ultimate energy source in future. Unlike the United States, hydrogen use and delivery in liquid form is extremely limited in the European Union and in Japan. Iwatani Corporation broke through industry stereotypes by creating and building Hydro Edge Co. Ltd., Japan's largest liquid hydrogen plant. It was established in 2006 as a joint venture between Iwatani and Kansai Electric Power Group in Osaka. Hydro Edge is Japan's first combined liquid hydrogen and ASU plant, and is fully operational. Liquid oxygen, liquid nitrogen and liquid argon are separated from air using the cryogenic energy of liquefied natural gas fuel that is used for power generation. Liquid hydrogen is produced efficiently and simultaneously using liquid nitrogen. Approximately 12 times as much hydrogen in liquid form can be transported and supplied as pressurized hydrogen gas. This technology is a significant step forward in the dissemination and expansion of hydrogen in a hydrogen-based economy.

  8. Photovoltaics in Japan

    Science.gov (United States)

    Shimada, K.

    1985-01-01

    Report surveys status of research and development on photovoltaics in Japan. Report based on literature searches, private communications, and visits by author to Japanese facilities. Included in survey are Sunshine Project, national program to develop energy sources; industrial development at private firms; and work at academic institutions.

  9. [[Interregional marriage in Japan

    Science.gov (United States)

    Suzuki, T

    1990-07-01

    Patterns in interregional marriage in Japan are examined by prefecture. Data are from the 1977, 1982, and 1987 National Fertility Surveys and are presented for distance between marriage site and birthplace, including the effects of arranged marriage and wife's labor force participation; prior living arrangements; and educational status of the couple. (SUMMARY IN ENG)

  10. Moral Education in Japan.

    Science.gov (United States)

    Klaus, Luhmer

    1990-01-01

    Explores how religion is a pervasive influence in moral education in both the home and school in Japan, despite an official secular policy. Points out that after 1945 nationalism was replaced by secular social studies. Finds western thought included with Buddhism and Confucianism in government decrees on the curriculum. Places newly reemerging…

  11. Teacher Education in Japan.

    Science.gov (United States)

    Shimahara, Nobuo

    A discussion is presented on the education of Japanese teachers, their roles in the schools, and proposed reforms in their education. In describing the pre-World War II background of teacher education in Japan, three ideological forces are discussed: Western thought that impacted upon early Meiji reforms, Confucianism, and nationalism. Western…

  12. Japan Hadron Facility

    CERN Document Server

    Hayano, R S

    1999-01-01

    Japan Hadron Facility (JHF) is a high-intensity proton accelerator complex consisting of a 200 MeV linac, a 3 GeV booster and a 50 GeV main ring. Its status and future possibilities of realizing a versatile antiproton facility at JHF are presented.

  13. Technical Communication in Japan

    Institute of Scientific and Technical Information of China (English)

    Hiraku Amemiya

    2010-01-01

    @@ 1.Characteristics of Japanese Technical Communication(TC) The visual orientation of information characterizes Japanese technical communication.Manuals that have won Japan Manual Awards in the past have employed various designs with graphical presentations that evoke the style of popular magazines.

  14. Sapovirus in Water, Japan

    OpenAIRE

    Hansman, Grant S.; Sano, Daisuke; Ueki, You; Imai, Takahiro; Oka, Tomoichiro; Katayama, Kazuhiko; Takeda, Naokazu; Omura, Tatsuo

    2007-01-01

    Sapoviruses are etiologic agents of human gastroenteritis. We detected sapovirus in untreated wastewater, treated wastewater, and a river in Japan. A total of 7 of 69 water samples were positive by reverse transcription–PCR. Phylogenetic analysis of the viral capsid gene grouped these strains into 4 genetic clusters.

  15. Political Corruption in Japan.

    Science.gov (United States)

    Reed, Steven R.; And Others

    1996-01-01

    Provides an overview of political corruption and its place in Japanese culture and society. Discusses recent scandals and efforts at political reform. These efforts are moving Japan from a "boss-patronage" system to a "civic-culture." Includes a table of post-war Japanese prime ministers and corruption scandals. (MJP)

  16. Words of Tohkaku Wada: medical heritage in Japan.

    Science.gov (United States)

    Matsumoto, M; Inoue, K; Kajii, E

    2001-02-01

    The origins of Japan's medical ideas, which are deeply rooted in its religion, culture and history, are not widely understood in medical societies of other countries. We have taken up the task of summarising this tradition here so that some insight can be gained into the unique issues that characterise the practice of medicine in Japan. We borrow from the sayings of Tohkaku Wada, a medical philosopher of late eighteenth-century Japan, for a look at Japanese medical tradition. Wada's medical thought was very much reflective of the Buddhism, Zen, and swordsmanship that informed eighteenth-century philosophy in Japan. His central concepts were "chu" and "sei", that is, complete and selfless dedication to the patient and the practice of medicine. This paper explores Wada's thought, explaining it mainly from the standpoint of Japanese traditional culture.

  17. CXC Chemokine Ligand 10 Controls Viral Infection in the Central Nervous System: Evidence for a Role in Innate Immune Response through Recruitment and Activation of Natural Killer Cells

    OpenAIRE

    Trifilo, Matthew J.; Montalto-Morrison, Cynthia; Stiles, Linda N.; Hurst, Kelley R.; Hardison, Jenny L.; Manning, Jerry E.; Masters, Paul S.; Lane, Thomas E.

    2004-01-01

    How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating innate immune responses. Herein, we evaluated the contributions of CXC chemokine ligand 10 (CXCL10) in promoting innate defense mechanisms following coronavirus infection of the C...

  18. Atmospheric circulation controls on the inter-annual variability in precipitation isotope ratio in Japan

    Directory of Open Access Journals (Sweden)

    N. Kurita

    2014-10-01

    in winter. Therefore, isotope-based proxy records archived in central Japan may enable us to examine past atmospheric circulation changes in East Asia in response to climate variability.

  19. Reductions in Central Venous Pressure by Lower Body Negative Pressure or Blood Loss Elicit Similar Hemodynamic Responses

    Science.gov (United States)

    2014-05-29

    individual r2 values and individual regression line slope values of hemodynamic variables vs. central venous pressure r2 r2 Range Slope Slope Range...JUL 2014 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Reductions in Central Venous Pressure by Lower Body Negative Pressure...ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Reductions in central venous pressure by

  20. Institutional perceptions, adaptive capacity and climate change response in a post-conflict country: a case study from Central African Republic

    NARCIS (Netherlands)

    Brown, H.C.P.; Smit, B.; Somorin, O.A.; Sonwa, D.J.; Ngana, F.

    2013-01-01

    The Central African Republic (CAR) faces increased vulnerability to climate change because it is a low-income country with low adaptive capacity; a situation that is exacerbated by recent civil conflict. This research analysed the perceptions of decision-makers within, and the response of diverse na

  1. [Comparison of antibody responses to hepatitis B surface antigen among four recipient groups of hepatitis B vaccines that have been approved in Japan: evaluation using passive hemagglutination assay and chemiluminescent immunoassay].

    Science.gov (United States)

    Ogata, Norio

    2009-10-01

    In hepatitis B virus (HBV) infection-preventing programs, serum or plasma levels of antibody to hepatitis B surface antigen (anti-HBs) are important to determine whether individuals are protective or not. We compared anti-HBs responses using passive hemagglutination assay (Mycell) and chemiluminescent immunoassay (Architect) among four recipient groups of HB vaccines, Meinyu, HBY, Bimmugen and Heptavax II, that have been approved in Japan. Overall, in a total of 1875 vaccinees Mycell results showed recipient groups of Meinyu and HBY acquired higher anti-HBs levels than those of Bimmugen and Heptavax II. Comparison of anti-HBs responses by both Mycell and Architect in recipient groups of Meinyu (n=150), HBY (n=218), Bimmugen (n=260), and Heptavax II (n=47) demonstrated the order of vaccinees' responses, such as geometric mean titers, ratios of acquiring high antibody levels (Mycell titers over 1024, Architect measurements over 1000 mIU/mL), and ratios of having unsuccessful antibody responses (Mycell titers under 8, Architect measurements under 10 mIU/mL), were somewhat different between the two assays. Comparison of Architect measurements at given Mycell titers revealed Bimmugen-recipients showed significantly lower values than HBY- or Heptavax II-recipients. Around critical protective levels, 5 of 22 Bimmugen-recipients with Mycell titers 16 or 32 showed Architect measurements under 10 mIU/mL, while 8 of 11 Heptavax II-recipients with Mycell titers below 8 demonstrated Architect measurements over 10 mIU/mL. Thus, discrepancies in anti-HBs evaluation between Mycell and Architect seemed to partly depend on administered vaccines. These results indicate anti-HBs concentration should be evaluated carefully so that we could completely prevent HBV infection.

  2. Dinoflagellate cyst biostratigraphy and age of the Oligocene Momijiyama formation, Yubari Coal-Field, central Hokkaido, Japan; Hokkaido yubari tanden chiiki, zenshinto momijiyamaso no kaben moso kasekisojo to nendai

    Energy Technology Data Exchange (ETDEWEB)

    Kurita, H.; Miwa, M. [Japan Petroleum Exploration Co. Ltd., Chiba (Japan). JAPEX Research Center

    1998-01-15

    The Momijiyama formation distributed in the Yubari coalfield region of Hokkaido is one of the typical sea Oligocenes in the northern Japan. However, there has been much argument about the age of the Momijiyama formation. This paper reports newly-obtained findings concerning the upper limit age of the Momijiyama formation determined by the analysis of a dinoflagellate fossil, an organic microfossil, conducting a fission track (FT) age determination, and putting together the results of the analysis and determination and the results of the analysis of dinoflagellate fossil reported by Kurita and Matsuoka (1994). It can currently be concluded on the basis of both the data on the dinoflagellate cyst biostratigraphy which were obtained in the Hobetsu region and those on the radioactive data that the upper limit age of the Momijiyama formation is an initial period of the Oligocene epoch. The age of the floating foraminifer and the calcareous nannofossil produced from the upper portion of the Horonai formation, a formation on the lower layer of the Momijiyama formation is the final period of the Eocene or the initial period of the Oligocene. Therefore, it is considered that the lower limit age of the Momijiyama formation is substantially before or after the transition from the Eocene epoch to the Oligocene epoch. 19 refs., 4 figs., 1 tab.

  3. Central Solenoid Insert Technical Specification

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, Nicolai N [ORNL; Smirnov, Alexandre [ORNL

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  4. Comparative evaluation of central venous pressure and sonographic inferior vena cava variability in assessing fluid responsiveness in septic shock

    Directory of Open Access Journals (Sweden)

    Manjri Garg

    2016-01-01

    Full Text Available Objective: Fluid infusion, the most critical step in the resuscitation of patients with septic shock, needs preferably continuous invasive hemodynamic monitoring. The study was planned to evaluate the efficacy of ultrasonographically measured inferior vena cava collapsibility index (IVC CI in comparison to central venous pressure (CVP in predicting fluid responsiveness in septic shock. Materials and Methods: Thirty-six patients of septic shock requiring ventilatory support (invasive/noninvasive were included. Patients with congestive heart failure, raised intra-abdominal pressure, and poor echo window were excluded from the study. They were randomly divided into two groups based on mode of fluid resuscitation - Group I (CVP and Group II (IVC CI. Primary end-points were mean arterial pressure (MAP of ≥65 mmHg and CVP >12 mmHg or IVC CI <20% in Groups I and II, respectively. Patients were followed till achievement of end-points or maximum of 6 h. Outcome variables (pulse rate, MAP, urine output, pH, base deficit, and ScvO 2 were serially measured till the end of the study. Survival at 2 and 4 weeks was used as secondary end-point. Results: Primary end-point was reached in 31 patients (15 in Group I and 16 in Group II. Fluid infusion, by either method, had increased CVP and decreased IVC CI with resultant negative correlation between them (Pearson correlation coefficient -0.626. There was no significant difference in the amount of fluid infused and time to reach end-point in two groups. Comparison in outcome variables at baseline and end-point showed no significant difference including mortality. Conclusion: CVP and IVC CI are negatively correlated with fluid resuscitation, and both methods can be used for resuscitation, with IVC CI being noninferior to CVP.

  5. Central metabolic responses to the overproduction of fatty acids in Escherichia coli based on 13C-metabolic flux analysis.

    Science.gov (United States)

    He, Lian; Xiao, Yi; Gebreselassie, Nikodimos; Zhang, Fuzhong; Antoniewiez, Maciek R; Tang, Yinjie J; Peng, Lifeng

    2014-03-01

    We engineered a fatty acid overproducing Escherichia coli strain through overexpressing tesA (“pull”) and fadR (“push”) and knocking out fadE (“block”). This “pull-push-block” strategy yielded 0.17 g of fatty acids (C12–C18) per gram of glucose (equivalent to 48% of the maximum theoretical yield) in batch cultures during the exponential growth phase under aerobic conditions. Metabolic fluxes were determined for the engineered E. coli and its control strain using tracer ([1,2-13C]glucose) experiments and 13C-metabolic flux analysis. Cofactor (NADPH) and energy (ATP) balances were also investigated for both strains based on estimated fluxes. Compared to the control strain, fatty acid overproduction led to significant metabolic responses in the central metabolism: (1) Acetic acid secretion flux decreased 10-fold; (2) Pentose phosphate pathway and Entner–Doudoroff pathway fluxes increased 1.5- and 2.0-fold, respectively; (3) Biomass synthesis flux was reduced 1.9-fold; (4) Anaplerotic phosphoenolpyruvate carboxylation flux decreased 1.7-fold; (5) Transhydrogenation flux converting NADH to NADPH increased by 1.7-fold. Real-time quantitative RT-PCR analysis revealed the engineered strain increased the transcription levels of pntA (encoding the membrane-bound transhydrogenase) by 2.1-fold and udhA (encoding the soluble transhydrogenase) by 1.4-fold, which is in agreement with the increased transhydrogenation flux. Cofactor and energy balances analyses showed that the fatty acid overproducing E. coli consumed significantly higher cellular maintenance energy than the control strain. We discussed the strategies to future strain development and process improvements for fatty acid production in E. coli.

  6. Carbon and nitrogen allocations in corn grown in Central and Northeast China:different responses to fertilization treatments

    Institute of Scientific and Technical Information of China (English)

    MIAO Hui-tian; L Jia-long; XU Ming-gang; ZHANG Wen-ju; HUANG Shao-min; PENG Chang; CHEN Li-ming

    2015-01-01

    In order to reveal the impact of various fertilization strategies on carbon (C) and nitrogen (N) accumulation and al ocation in corn (Zea mays L.), corn was grown in the ifelds where continuous fertilization management had been lasted about 18 years at two sites located in Central and Northeast China (Zhengzhou and Gongzhuling), and biomass C and N contents in different organs of corn at harvest were analyzed. The fertilization treatments included non-fertilizer (control), chemical fertilizers of either nitrogen (N), or nitrogen and phosphorus (NP), or phosphorus and potassium (PK), or nitrogen, phospho-rus and potassium (NPK), NPK plus manure (NPKM), 150%of the NPKM (1.5NPKM), and NPK plus straw (NPKS). The results showed that accumulated C in aboveground ranged from 2 550–5 630 kg ha–1 in the control treatment to 9 300–9 610 kg ha–1 in the NPKM treatment, of which 57–67%and 43–50%were al ocated in the non-grain organs, respectively. Accumulated N in aboveground ranged from 44.8–55.2 kg ha–1 in the control treatment to 211–222 kg ha–1 in the NPKM treatment, of which 35–48% and 33–44% were al ocated in the non-grain parts, respectively. C al ocated to stem and leaf for the PK treatment was 65 and 49%higher than that for the NPKM treatment at the both sites, respectively, while N al ocated to the organs for the PK treatment was 18 and 6%higher than that for the NPKM treatment, respectively. This study demonstrated that responses of C and N al ocation in corn to fertilization strategies were different, and C al ocation was more sensitive to fertilization treatments than N al ocation in the area.

  7. Assessment of soil erosion sensitivity and post-timber-harvesting erosion response in a mountain environment of Central Italy

    Science.gov (United States)

    Borrelli, Pasquale; Schütt, Brigitta

    2014-01-01

    This study aimed to assess the effects of forest management on the occurrence of accelerated soil erosion by water. The study site is located in a mountainous area of the Italian Central Apennines. Here, forest harvesting is a widespread forestry activity and is mainly performed on the moderate to steep slopes of the highlands. Through modeling operations based on data on soil properties and direct monitoring of changes in the post-forest-harvesting soil surface level at the hillslope scale, we show that the observed site became prone to soil erosion after human intervention. Indeed, the measured mean soil erosion rate of 49 t ha- 1 yr- 1 for the harvested watershed is about 21 times higher than the rate measured in its neighboring undisturbed forested watershed (2.3 t ha- 1 yr- 1). The erosive response is greatly aggravated by exposing the just-harvested forest, with very limited herbaceous plant cover, to the aggressive attack of the heaviest annual rainfall without adopting any conservation practices. The erosivity of the storms during the first four months of field measurements was 1571 MJ mm h- 1 ha- 1 in total (i.e., from September to December 2008). At the end of the experiment (16 months), 18.8%, 26.1% and 55.1% of the erosion monitoring sites in the harvested watershed recorded variations equal or greater than 0-5, 5-10 and > 10 mm, respectively. This study also provides a quantification of Italian forestland surfaces with the same pedo-lithological characteristics exploited for wood supply. Within a period of ten years (2002-2011), about 9891 ha of coppice forest changes were identified and their potential soil erosion rates modeled.

  8. Short-term response of the solid Earth to cryosphere fluctuations and the earthquake cycle in south-central Alaska

    Science.gov (United States)

    Sauber, J. M.; Freymueller, J. T.; Han, S. C.; Davis, J. L.; Ruppert, N. A.

    2016-12-01

    In southern Alaska surface deformation and gravimetric change are associated with the seismic cycle as well as a strong seasonal cycle of snow accumulation and melt and a variable rate of glacier mass wastage. Numerical modeling of the solid Earth response to cryosphere change on a variety of temporal and spatial scales plays a critical role in supporting the interpretation of time-variable gravity and other geodetic data. In this study we calculate the surface displacements and stresses associated with variable spatial and temporal cryospheric loading and unloading in south-central coastal Alaska. A challenging aspect of estimating the response of the solid Earth to short-term (months to 102 years) regional cryospheric fluctuations is choosing the rock mechanics constitutive laws appropriate to this region. Here we report calculated differences in the predicted surface displacements and stresses during the GRACE time period (2002 to present). Broad-scale, GRACE-derived estimates of cryospheric mass change, along with independent snow melt onset/refreeze timing, snow depth and annual glacier wastage estimates from a variety of methods, were used to approximate the magnitude and timing of cryospheric load changes. We used the CIG finite element code PyLith to enable input of spatially complex surface loads. An as example of our evaluation of the influence of variable short-term surface loads, we calculated and contrasted the predicted surface displacements and stresses for a cooler than average and higher precipitation water year (WY12) versus a warmer than average year (WY05). Our calculation of these comparative stresses is motivated by our earlier empirical evaluation of the influence of short-term cryospheric fluctuations on the background seismic rate between 1988-2006 (Sauber and Ruppert, 2008). During the warmer than average years between 2002-2006 we found a stronger seasonal dependency in the frequency of small tectonic events in the Icy Bay region relative

  9. Effects of subchronic treatment with valproate on L-5-HTP-induced cortisol responses in mania: evidence for increased central serotonergic neurotransmission.

    Science.gov (United States)

    Maes, M; Calabrese, J; Jayathilake, K; Meltzer, H Y

    1997-07-04

    The mechanisms underlying the acute and prophylactic antimanic properties of valproate have remained elusive. There are some reports that treatment with valproic acid may increase brain serotonergic neurotransmission in the rodent. This study was carried out in order to investigate the effects of subchronic therapy with valproate on central serotonin metabolism in manic patients. Toward this end, the authors examined plasma cortisol responses to 200 mg (orally) L-5-hydroxy-tryptophan (L-5-HTP) in 10 manic patients both before and after subchronic treatment with valproate. Administration of L-5-HTP resulted in significantly increased cortisol responses both before and after treatment with valproate. The L-5-HTP-induced cortisol responses were significantly higher after treatment with valproate than before treatment. It is suggested that valproate may increase central serotonergic neurotransmission and that this stimulation may play a role in the antimanic effects of valproate.

  10. DPAL activities in Japan

    Science.gov (United States)

    Endo, Masamori; Wani, Fumio

    2015-02-01

    Activities on diode pumped alkali laser (DPAL) in Japan is reviewed. We have started alkali laser works in 2011, and currently, we are the only players in Japan. Our interests are application oriented, and it is not only defense but also industrial. DPAL is a good candidate as a source of remote laser machining, thanks to its scalability and extremely good beam quality. We are studying on scientific and engineering problems of Cs DPAL with a small-scale apparatus. A commercial diode laser with volume Bragg grating outcoupler is used to pump the gain cell longitudinally. A 6.5 W continuous-wave output with optical to optical efficiency of 56% (based on the absorbed power) has been achieved. Numerical simulation codes are developed to understand the physics of DPAL and to help future developments.

  11. [Gambling disorder in Japan].

    Science.gov (United States)

    Tanabe, Hitoshi

    2015-09-01

    Gambling disorder is a psychiatric disorder characterized by persistent and recurrent problematic gambling behavior, associated with impaired functioning, reduced quality of life, and frequent divorce and bankruptcy. Gambling disorder is reclassified in the category Substance-Related and Addictive Disorders in the DSM-5 because its clinical features closely resemble those of substance use disorders, and gambling activates the reward system in brain in much the same way drugs do. Prevalence of gambling disorder in Japan is high rate because of slot machines and pachinko game are very popular in Japan. The author recommend group psychotherapy and self-help group (Gamblers Anonymous), because group dynamics make them accept their wrongdoings related to gambling and believe that they can enjoy their lives without gambling.

  12. Sapporo, Hokkaido, Japan

    Science.gov (United States)

    1992-01-01

    The city of Sapporo on the northernmost of the Japanese Home Island of Hokkaido (43.5N, 141.5E), host to the 1986 Winter Olympic Games is situated along the margin of a large valley which extends across the island from the Sea of Japan to the Pacific Ocean. The Valley is largely cultivated (the lighter green of the cultivated land distinguishes it from the gray urban development of Sapporo), but much of the island remains heavily forested.

  13. Japan Report No. 173.

    Science.gov (United States)

    2007-11-02

    Also, when Mr Nikaido visited China, his statements regarding Japan’s present situation and the Nakasone cabinet were filled with polite sarcasm . In...t— o Ov ON OS UJ o cu O OS Q > X eS UJ o a. O ei a >• X cu D OS UJ O a. J < S in fN OS OS n OS < «r z UJ w Z JL1 -J -J J Ou

  14. Marital Dissolution in Japan

    OpenAIRE

    James M. Raymo; Bumpass, Larry L.; Miho Iwasawa

    2004-01-01

    Very little is known about recent trends in divorce in Japan. In this paper, we use Japanese vital statistics and census data to describe trends in the experience of marital dissolution across the life course, and to examine change over time in educational differentials in divorce. Cumulative probabilities of marital dissolution have increased rapidly across successive marriage cohorts over the past twenty years, and synthetic period estimates suggest that roughly one-third of Japanese marria...

  15. Responsible Investing in the Asia-Pacific Region: Understanding Sustainability and Investments in Japan and Hong Kong/China in an Era of Global Climate and Environmental Change

    NARCIS (Netherlands)

    J. Park (Jacob)

    2014-01-01

    markdownabstract__Abstract__ The author of this thesis examined the concept and market development of responsible investing (RI), which can be defined as an investment process that integrates social and environmental considerations within the context of traditional investment processes. RI has beco

  16. Chinese University Students Delegation For Musical Exchanges Visits Japan

    Institute of Scientific and Technical Information of China (English)

    Fu; Bo

    2014-01-01

    <正>Invited by the Japan-China Friendship Center(CJFC),an 83-member Chinese university students’delegation visited Tokyo and Hokkaido from July 9 to 16.It comprised students and teachers of the music specialty of the Central Conservatory of Music,the School of Music of the Minzu University of China and the Shanghai Conservatory of Music.

  17. The New Era of Geography Education in Japan.

    Science.gov (United States)

    Nakayama, Shuichi

    1996-01-01

    Summarizes the recent changes in the highly centralized national geography curriculum in Japan. Prominent reforms include the implementation of environmental studies in the elementary schools and a broader emphasis, across the curriculum, on world geography. In teacher education, emphasis is now placed on teaching skills rather than subject…

  18. Significance of Size of Persistent/Recurrent Central Nodal Disease on Surgical Morbidity and Response to Therapy in Reoperative Neck Dissection for Papillary Thyroid Carcinoma.

    Science.gov (United States)

    Lang, Brian Hung-Hin; Shek, Tony W H; Chan, Angel On-Kei; Lo, Chung-Yau; Wan, Koon Yat

    2017-01-01

    To balance the risk of disease progression, morbidity, and efficacy of reoperative central neck dissection (RCND) in papillary thyroid carcinoma, the latest clinical guidelines recommend early surgery over surveillance when the largest diseased node is >8 mm in its smallest dimension. However, the evidence remains scarce. To determine an appropriate size for first-time RCND, the relationship between size of largest diseased central node, morbidity, and response-to-therapy following RCND was examined. A total of 130 patients who underwent RCND following initial surgery for persistent/recurrent nodal disease were reviewed. Patients with largest diseased central node measured preoperatively by ultrasonography were included. Eligible patients were categorized into three groups: largest central node 15 mm (group III). Surgical morbidity and response to therapy at one year after RCND were compared between groups. To evaluate biochemical response, patients with structural incompleteness were excluded. Group III not only had significantly more high-risk tumors (by American Thyroid Association risk stratification) at initial therapy (64.5% vs. 44.4%, respectively; p = 0.038), but this group also a higher risk of extranodal extension (35.5% vs. 16.0%; p = 0.055), recurrent laryngeal nerve involvement (19.4% vs. 0.0%; p 15 mm in the largest disease central node was an independent risk factor for incomplete biochemical response, while nodal size 10-15 mm was not. These findings imply that the recommended threshold of 8 mm might be too stringent and could be raised to 15 mm without increasing the surgical morbidity from RCND.

  19. Urologic cancer in Japan: role of Japan at the frontier of issues in Asia.

    Science.gov (United States)

    Akaza, Hideyuki

    2016-01-01

    The characteristics of urological cancer in Japan can be summarized in the following points. (i) As the onset of this type of cancer is typically seen in elderly patients, it is becoming a major social issue in Japan that has already become an aging society. (ii) Many diverse treatment methods are available and a response is required that prioritizes quality of life. (iii) Although vigorous research and development efforts into new drugs are being carried out on a global level, resulting in beneficial medical agents becoming more readily available, unless concepts relating to cost vs. effectiveness are further developed and there is a real risk that medical systems and structures in their current form will become unsustainable. (iv) Although at the current point there are no original large-scale clinical trials being conducted in Asia, Japan has a wealth of experience of participating in many international joint clinical trials and it is therefore an urgent and pressing challenge to organize joint clinical trials in Asia and amass a body of knowledge that is unique to Asia. In view of this current situation and given Japan's position at the frontier of issues, it is important for Japan to take the initiative in Asia in cooperating with other Asian nations in efforts to resolve and overcome various challenges.

  20. CPC's Propositions and Actions of Resistance Against Japan in the Central Soviet Area%中央苏区时期中共抗日主张及其实践研究

    Institute of Scientific and Technical Information of China (English)

    朱钦胜; 陈刚

    2015-01-01

    自红军转战赣南后,苏区长期面临着国民党多次"围剿"的军事压力.随着日本悍然发动"九?一八"事变,中国局势更加复杂.在民族生死存亡面前,中共以民族大义为重,呼吁国民党停止进攻苏区,同时宣布了一系列抗日主张,并付诸实践.这些主张不仅得到工农大众支持,而且许多国民党下层军官也自动加入中共抗日大军中,甚至日本国内反战力量也积极响应号召.%Since the Red Army fought in Gannan, South Jiangxi, Soviet Area faced a sustained, enormous pressure from the KMT encirclement and suppression. As Japan launched a brutal Sept. 18th Incident, the situation in China got more complicated. At the vital moment, the CPC thought of overall national interests first, appealed the KMT to stop attacking Soviet Area, announced a series of anti-Japanese proposition, and put into practice. These claims were not only supported by workers and peasants, and many White Army grass-root officers also voluntarily joined in CPC anti-Japanese army. Even Japanese anti-war forces actively responded to CPC's call.

  1. China-Japan Friendship Association Delegation in Japan

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Invited by the Shorinji Kem-po Group and the Japan-China Friendship Association (JC-FA), the China-Japan Friendship Association (CJFA) delegation led by Vice President Jing Dun-quan visited Tokyo, Miyazaki and Fukuoka from November 2 to 9, 2007. During its stay in Japan, from November 2 to 4, the delegation attended a series of activities celebrating the 60th

  2. Report of Surrender and Occupation of Japan

    Science.gov (United States)

    1946-05-09

    for the entry of the forces into Tokyo Bay. Before any units were permitted to use this channel, however, it was swept by our own minecraft (TU...Northern Japan Area became the responsibility of SCAJAP. (2) Any further minesweeping to be conducted in the area would be supervised by Commander Minecraft ...Other minecraft have fared less fortunately from operational causes. In the typhoon of 16 September, 5 YMSs were lost; and during the severe typhoon

  3. Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan

    Science.gov (United States)

    Watanabe, Masanari; Noma, Hisashi; Kurai, Jun; Sano, Hiroyuki; Hantan, Degejirihu; Ueki, Masaru; Kitano, Hiroya; Shimizu, Eiji

    2016-01-01

    The relationship between particulate air pollutants and respiratory symptoms in children has not been consistent among studies, potentially owing to differences in the inflammatory response to different particulate air pollutants. This study aimed to investigate the effect of particulate air pollutants on respiratory symptoms and the inflammatory response in schoolchildren. Three hundred-and-sixty children were included in the study. The children recorded daily respiratory symptom scores for October 2015. In addition, the daily amount of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α production was assessed in THP1 cells stimulated with suspended particulate matter (SPM), which was collected every day during the study period. Generalized estimating equation logistic regression analyses were used to estimate the associations among respiratory symptoms and the daily levels of SPM, IL-6, IL-8, and TNF-α. Daily SPM levels were not associated with respiratory symptoms or the daily IL-6, IL-8, and TNF-α levels. Conversely, there was a significant association between respiratory symptoms and the daily IL-6, IL-8, and TNF-α levels. These results suggested that the effects of particulate air pollutants on respiratory symptoms in schoolchildren might depend more on the pro-inflammatory response to them than on their mass concentration. PMID:27706066

  4. GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord ☆

    OpenAIRE

    Corns, Laura F; Deuchars, Jim; Deuchars, Susan A

    2013-01-01

    The area surrounding the central canal of the postnatal mammalian spinal cord is a highly plastic region that exhibits many similarities to other postnatal neurogenic niches, such as the subventricular zone. Within this region, ependymal cells have been identified as neural stem cells however very little is known about their properties and how the local environment, including neurotransmitters, is capable of affecting them. The neurotransmitter GABA is present around the central canal and is ...

  5. A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats.

    Science.gov (United States)

    Ibrahim, Badr Mostafa; Abdel-Rahman, Abdel A

    2015-10-05

    Orexin receptor 1 (OX1R) signaling is implicated in cannabinoid receptor 1 (CB1R) modulation of feeding. Further, our studies established the dependence of the central CB1R-mediated pressor response on neuronal nitric oxide synthase (nNOS) and extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation in the RVLM. Here, we tested the novel hypothesis that brainstem orexin-A/OX1R signaling plays a pivotal role in the central CB1R-mediated pressor response. Our multiple labeling immunofluorescence findings revealed co-localization of CB1R, OX1R and the peptide orexin-A within the C1 area of the rostral ventrolateral medulla (RVLM). Activation of central CB1R following intracisternal (i.c.) WIN55,212-2 (15μg/rat) in conscious rats caused significant increases in BP and orexin-A level in RVLM neuronal tissue. Additional studies established a causal role for orexin-A in the central CB1R-mediated pressor response because (i) selective blockade of central CB1R (AM251, 30μg/rat; i.c.) abrogated WIN55,212-2-evoked increases in RVLM orexin-A level, (ii) the selective OX1R antagonist SB-408124 (10nmol/rat; i.c.) attenuated orexin-A (3nmol/rat; i.c.) or WIN55,212-2 (15μg/rat; i.c.)-evoked pressor response while selective CB1R blockade (AM251) had no effect on orexin-A (3nmol/rat; i.c.)-evoked pressor response, (iii) direct CB1R activation in the RVLM (WIN55,212-2; 0.1μg/rat) increased RVLM orexin-A and BP. Finally, SB-408124 attenuated WIN55,212-2-evoked increases in RVLM nNOS and ERK1/2 phosphorylation and BP. Our findings suggest that orexin-A/OX1R dependent activation of the RVLM nNOS/ERK1/2 cascade is essential neurochemical mechanism for the central CB1R-mediated pressor response in conscious rats.

  6. Overview of spherical tokamak research in Japan

    Science.gov (United States)

    Takase, Y.; Ejiri, A.; Fujita, T.; Fukumoto, N.; Fukuyama, A.; Hanada, K.; Idei, H.; Nagata, M.; Ono, Y.; Tanaka, H.; Uchida, M.; Horiuchi, R.; Kamada, Y.; Kasahara, H.; Masuzaki, S.; Nagayama, Y.; Oishi, T.; Saito, K.; Takeiri, Y.; Tsuji-Iio, S.

    2017-10-01

    Nationally coordinated research on spherical tokamak is being conducted in Japan. Recent achievements include: (i) plasma current start-up and ramp-up without the use of the central solenoid by RF waves (in electron cyclotron and lower hybrid frequency ranges), (ii) plasma current start-up by AC Ohmic operation and by coaxial helicity injection, (iii) development of an advanced fuelling technique by compact toroid injection, (iv) ultra-long-pulse operation and particle control using a high temperature metal wall, (v) access to the ultra-high-β regime by high-power reconnection heating, and (vi) improvement of spherical tokamak plasma stability by externally applied helical field.

  7. Linking the runoff response at micro-plot and catchment scale following wildfire and terracing, north-central Portugal

    Science.gov (United States)

    Martins, Martinho A. S.; Rial-Rivas, María E.; Machado, Ana I.; Serpa, Dalila; Prats, Sergio A.; Faria, Sílvia R.; Varela, María E. T.; González-Pelayo, Óscar; Keizer, J. Jacob

    2015-04-01

    Wildfires are known as one of the principal natural hazards affecting the Mediterranean region. This includes Portugal, where wildfires have affected some 100.000 ha of rural lands each year. The effects of wildfires on runoff generation and/or the associated soil (fertility) losses have been studied in Portugal for more than two decades. Some of these studies have reported strong and sometimes extreme hydrological responses in recently burnt areas. Forestry operations in such areas have increasingly come to include bench terracing in preparation of new eucalypt plantations. The hydrological impacts of bench terracing, however, have received little research attention so far and the few existing publications are limited to small spatial scales. The construction of terraces is commonly considered an effective practice for soil conservation on steep slopes, having been applied by mankind since early history. Nonetheless, the present authors have measured high rates of splash as well as inter-rill erosion on recently constructed terraces, and have regularly observed rill formation, including on forest tracks which typically constitute an extensive network in such bench terraced plantations. The present study was carried out in a 29-ha forest catchment in north-central Portugal that was burnt by a wildfire during the summer of 2010, logged during early winter 2010/11, and then bench terraced with bulldozers during late winter 2011, some 6 months after the wildfire. The catchment outlet was instrumented immediately after the fire with an automatic hydrometric station comprising two subsequent flumes with maximum discharge capacities of 120 and 1700 l sec-1. Within the catchment, rainfall was measured using several automatic and storage gauges and overland flow was monitored on two contrasting slopes using 3 micro-plots of approximately 0.25m2 on each slope.Overland flow was measured at 1- to 2-weekly intervals during the hydrological years of 2010/11 and 2011/12, i

  8. KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan.

    Directory of Open Access Journals (Sweden)

    Yuichi Nozawa

    Full Text Available Natural killer cell responses play a crucial role in virus clearance by the innate immune system. Although the killer immunoglobulin-like receptor (KIR in combination with its cognate human leukocyte antigen (HLA ligand, especially KIR2DL3-HLA-C1, is associated with both treatment-induced and spontaneous clearance of hepatitis C virus (HCV infection in Caucasians, these innate immunity genes have not been fully clarified in Japanese patients. We therefore investigated 16 KIR genotypes along with HLA-B and -C ligands and a genetic variant of interleukin (IL 28B (rs8099917 in 115 chronic hepatitis C genotype 1 patients who underwent pegylated-interferon-α2b (PEG-IFN and ribavirin therapy. HLA-Bw4 was significantly associated with a sustained virological response (SVR to treatment (P = 0.017; odds ratio [OR] = 2.50, , as was the centromeric A/A haplotype of KIR (P = 0.015; OR 3.37. In contrast, SVR rates were significantly decreased in patients with KIR2DL2 or KIR2DS2 (P = 0.015; OR = 0.30, and P = 0.025; OR = 0.32, respectively. Multivariate logistic regression analysis subsequently identified the IL28B TT genotype (P = 0.00009; OR = 6.87, 95% confidence interval [CI] = 2.62 - 18.01, KIR2DL2/HLA-C1 (P = 0.014; OR = 0.24, 95% CI = 0.08 - 0.75, KIR3DL1/HLA-Bw4 (P = 0.008, OR = 3.32, 95% CI = 1.37 - 8.05, and white blood cell count at baseline (P = 0.009; OR = 3.32, 95% CI = 1.35 - 8.16 as independent predictive factors of an SVR. We observed a significant association between the combination of IL28B TT genotype and KIR3DL1-HLA-Bw4 in responders (P = 0.0019, whereas IL28B TT along with KIR2DL2-HLA-C1 was related to a non-response (P = 0.0067. In conclusion, combinations of KIR3DL1/HLA-Bw4, KIR2DL2/HLA-C1, and a genetic variant of the IL28B gene are predictive of the response to PEG-IFN and ribavirin therapy in Japanese patients infected with genotype 1b HCV.

  9. Investing in Japan? Statistics Speak

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin

    2009-01-01

    @@ Is investing in Japan a good choice for ambitious Chinese enterprises? Xiong Lin, partner at the Beijing DaDi Law firm, reminded potential investors that understanding Sino-Japan cultural differences, local policies and the procedures concerning investment, as well as protecting intellectual property and prompt communication with local con-sulting finns are the keys to good prepa-ration. She gave this advice at the "2009 Investment in Japan Seminar" on March 5, a seminar co-hosted by CCPIT (China Council for the promotion of International Trade) and JETRO (Japan External Trade Organization) as the follow-up to a session held in 2007.

  10. JPRS Report, Science & Technology, Japan

    Science.gov (United States)

    2007-11-02

    This is Japan Report with Science and Technology. It contains the issues with different topics on biotecnology , defense industry, nuclear engineering, Marine technology, science and technology policy.

  11. Forced Migration and Global Responsibility for Health; Comment on “Defining and Acting on Global Health: The Case of Japan and the Refugee Crisis”

    Directory of Open Access Journals (Sweden)

    Kayvan Bozorgmehr

    2017-07-01

    Full Text Available Forced migration has become a world-wide phenomenon in the past century, affecting increasing numbers of countries and people. It entails important challenges from a global health perspective. Leppold et al have critically discussed the Japanese interpretation of global responsibility for health in the context of forced migration. This commentary complements their analysis by outlining three priority areas of global health responsibility for European Union (EU countries. We highlight important stages of the migration phases related to forced migration and propose three arguments. First, the chronic neglect of the large number of internally displaced persons (IDPs in the discourses on the “refugee crisis” needs to be corrected in order to develop sustainable solutions with a framework of the Sustainable Development Goals (SDGs. Second, protection gaps in the global system of protection need to be effectively closed to resolve conflicts with border management and normative global health frameworks. Third, effective policies need to be developed and implemented to meet the health and humanitarian needs of forced migrants; at the same time, the solidarity crisis within the EU needs to be overcome. These stakes are high. EU countries, being committed to global health, should urgently address these areas.

  12. Forced Migration and Global Responsibility for Health Comment on "Defining and Acting on Global Health: The Case of Japan and the Refugee Crisis".

    Science.gov (United States)

    Bozorgmehr, Kayvan; Razum, Oliver

    2016-11-05

    Forced migration has become a world-wide phenomenon in the past century, affecting increasing numbers of countries and people. It entails important challenges from a global health perspective. Leppold et al have critically discussed the Japanese interpretation of global responsibility for health in the context of forced migration. This commentary complements their analysis by outlining three priority areas of global health responsibility for European Union (EU) countries. We highlight important stages of the migration phases related to forced migration and propose three arguments. First, the chronic neglect of the large number of internally displaced persons (IDPs) in the discourses on the "refugee crisis" needs to be corrected in order to develop sustainable solutions with a framework of the Sustainable Development Goals (SDGs). Second, protection gaps in the global system of protection need to be effectively closed to resolve conflicts with border management and normative global health frameworks. Third, effective policies need to be developed and implemented to meet the health and humanitarian needs of forced migrants; at the same time, the solidarity crisis within the EU needs to be overcome. These stakes are high. EU countries, being committed to global health, should urgently address these areas. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  13. Comparison of two large earthquakes: the 2008 Sichuan Earthquake and the 2011 East Japan Earthquake.

    Science.gov (United States)

    Otani, Yuki; Ando, Takayuki; Atobe, Kaori; Haiden, Akina; Kao, Sheng-Yuan; Saito, Kohei; Shimanuki, Marie; Yoshimoto, Norifumi; Fukunaga, Koichi

    2012-01-01

    Between August 15th and 19th, 2011, eight 5th-year medical students from the Keio University School of Medicine had the opportunity to visit the Peking University School of Medicine and hold a discussion session titled "What is the most effective way to educate people for survival in an acute disaster situation (before the mental health care stage)?" During the session, we discussed the following six points: basic information regarding the Sichuan Earthquake and the East Japan Earthquake, differences in preparedness for earthquakes, government actions, acceptance of medical rescue teams, earthquake-induced secondary effects, and media restrictions. Although comparison of the two earthquakes was not simple, we concluded that three major points should be emphasized to facilitate the most effective course of disaster planning and action. First, all relevant agencies should formulate emergency plans and should supply information regarding the emergency to the general public and health professionals on a normal basis. Second, each citizen should be educated and trained in how to minimize the risks from earthquake-induced secondary effects. Finally, the central government should establish a single headquarters responsible for command, control, and coordination during a natural disaster emergency and should centralize all powers in this single authority. We hope this discussion may be of some use in future natural disasters in China, Japan, and worldwide.

  14. Correlation between changes of central neurotransmitter expression and stress response in mice A restraint time-course analysis

    Institute of Scientific and Technical Information of China (English)

    Li Bao; Xinsheng Yao; Liang Zhao; Yanqing Lü; Hiroshi Kurihara

    2008-01-01

    BACKGROUND:Changes in central neurotransmitter expression play an important role in stress response and forms the basis for stress-induced psychological and behavior changes.OBJECTIVE:To observe the effects of different restraint stress intervals on brain monoamine neurotransmitter expression,and to investigate the correlation between stress response and neurotransmitter levels.DESIGN:Randomized controlled animal study.SETTING:Chinese Herb and Natural Medicine Institute,Pharmacological College of Jinan University.MATERIALS:Sixty 7-week-old male Kunming mice of clean grade,weighing 18-22 g,were provided by the Guangdong Medical Experimental Animal Center.The experiment was in accordance with animal ethics standards.METHODS:This study was performed at the Chinese Herb and Natural Medicine Institute,Pharmacological College of Jinan University from June 2006 to May 2007.A restraint device for mice was constructed according to published reports.Experimental mice were adaptively fed for 1 week and randomly divided into a control group(n=10)and an experimental group(n=50).The experimental group was sub-divided into five restraint intervals:4,8,12,18,and 24 hours(n=10 mice per time point).Animals in the experimental group were not allowed to eat or drink during the restraint period.Mice in the control group did not undergo restraint,but had identical food and water restrictions.Cerebral cortex and hypothalamus were separated based on observational times and protein was extracted using perchloric acid.Central monoamine neurotransmitter levels were measured using high performance liquid chromatography with electrochemical detection.MAIN OUTCOME MEASURES:Levels of norepinephrine(NE),dopamine hydrochloride(DA),3,4-dihydroxyphen-ylanetic acid (DOPAC),homovanillic acid(HVA),5-hydroxytryptamine(5-HT),and 5-hydroxyindoleac-etic acid(5-HIAA)in the cerebral cortex and hypothalamus of mice.RESULTS:Sixty mice were included in the final analysis.①NE levels in the cerebral

  15. Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Maryam Abedi

    2015-10-01

    Full Text Available In spite of huge efforts, chronic diseases remain an unresolved problem in medicine. Systems biology could assist to develop more efficient therapies through providing quantitative holistic sights to these complex disorders. In this study, we have re-analyzed a microarray dataset to identify critical signaling pathways related to diabetic nephropathy. GSE1009 dataset was downloaded from Gene Expression Omnibus database and the gene expression profile of glomeruli from diabetic nephropathy patients and those from healthy individuals were compared. The protein-protein interaction network for differentially expressed genes was constructed and enriched. In addition, topology of the network was analyzed to identify the genes with high centrality parameters and then pathway enrichment analysis was performed. We found 49 genes to be variably expressed between the two groups. The network of these genes had few interactions so it was enriched and a network with 137 nodes was constructed. Based on different parameters, 34 nodes were considered to have high centrality in this network. Pathway enrichment analysis with these central genes identified 62 inter-connected signaling pathways related to diabetic nephropathy. Interestingly, the central nodes were more informative for pathway enrichment analysis compared to all network nodes and also 49 differentially expressed genes. In conclusion, we here show that central nodes in protein interaction networks tend to be present in pathways that co-occur in a biological state. Also, this study suggests a computational method for inferring underlying mechanisms of complex disorders from raw high-throughput data.

  16. Educational Differences in Divorce in Japan

    Directory of Open Access Journals (Sweden)

    James M. Raymo

    2013-01-01

    Full Text Available BACKGROUND Evidence of a negative relationship between educational attainment and divorce in Japan is not consistent with predictions derived from standard theoretical emphases on the costs of divorce. OBJECTIVE Using marital history data from a cross-sectional survey, we estimated educational differences in divorce for two marriage cohorts: 1980-89 and 1990-2005. We also used 14 years of panel survey data to evaluate four possible explanations for the observed negative educational gradient. RESULTS Our results confirmed that educational attainment is inversely related to divorce in Japan, and showed that, in contrast to some previous findings, the negative relationship between women's education and divorce has not become stronger in recent years. Analyses of the panel data provided some support for hypotheses that focused on the role of economic strain and on cultural values regarding reputation or "face," but they also showed that the negative relationship between education and divorce remained strong even after controlling for a range of posited correlates. CONCLUSIONS Our failure to solve the theoretical puzzle motivating these analyses suggests that other types of contextual modification to standard theories of family change are required to explain the strong negative relationship between educational attainment and divorce in Japan. We discussed possible examples of such modifications, focusing on the patterns of selection into marriage and the central importance of investment in children's educational success in Japan's highly competitive educational system, while also offering more nuanced theorization regarding the role of reputation or "face".

  17. [Education of medicines in school education of Japan].

    Science.gov (United States)

    Kitagaki, Kunihiko

    2013-01-01

    World Health Organization (WHO) indicated that recognition of the responsibility of individuals for their own health and awareness that professional care for minor ailments is often unnecessary were important points of view for "Self-Medication" in "Guidelines for the Regulatory Assessment of Medicinal Products for Use in Self-Medication" published in 2000. In Japan, educational curriculum in each school is formulated by "the Courses of Study". Education for health at junior and senior high school is mainly carried out in "Health and Physical Education" class. The objectives are to enable students to develop qualities and abilities to appropriately manage and improve their health throughout their lives through understanding of health and safety in personal and social life. This idea is common with self-medication at a basic concept level. The previous Courses of Study were revised in 2008 and 2009. They described about medicine for senior but not junior high school. The interim report of "The Central Council for Education" in 2005 pointed out that understanding about effects/side effects by medicines, and abilities to use them appropriately are one of minimal qualities that all children must acquire. Due to revision of the Pharmaceutical Affairs Law in 2006, the necessity of endeavoring to widespread knowledge and enlighten about proper use of medicines in school education was considered. Since the new Courses of Study in the junior high school shows content that medicines should be used properly, it is thought that educational frame of medicines for children is going into new era in Japan.

  18. Dendritic cell-based vaccine for pancreatic cancer in Japan

    Institute of Scientific and Technical Information of China (English)

    Masato Okamoto; Masanori Kobayashi; Yoshikazu Yonemitsu; Shigeo Koido; Sadamu Homma

    2016-01-01

    "Vaccell" is a dendritic cell(DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DCmaturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity(DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be "Responders" for the DC vaccine in advanced pancreatic cancer patients. We next conducted a smallscale prospective clinical study. In this trial, we pulsed HLA class Ⅱ-restricted WT1 peptide(WT1-Ⅱ) in addition to HLA class Ⅰ-restricted peptide(WT1-Ⅰ) into the DCs. Survival of the patients received WT1-Ⅰ and-Ⅱ pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-Ⅰ or WT1-Ⅱ alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progressionfree survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan.

  19. Investigation of centrally and peripherally acting analgesic and anti inflammatory activity of biological immune response modulator (an Amazonian plant extract) in animal models of pain and inflammation

    OpenAIRE

    Mital Ravalji; Edwin Cevallos-Arellano; Suresh Balakrishnan

    2015-01-01

    Background: Biological immune response modulator (BIRM) - An aqueous extract of dried roots of the species Dulcamara (family Solanaceae) grown in Ecuador, considered as a natural remedy for various disease is promoted as a natural herbal medicine. Our aim of the study was to assess the central and peripheral analgesic and anti-inflammatory property of BIRM and to study its mechanism of action. Methods: Peripheral analgesic and anti-inflammatory activity was evaluated using acetic acid indu...

  20. Testing for shared biogeographic history in the lower Central American freshwater fish assemblage using comparative phylogeography: concerted, independent, or multiple evolutionary responses?

    Science.gov (United States)

    Bagley, Justin C; Johnson, Jerald B

    2014-05-01

    A central goal of comparative phylogeography is determining whether codistributed species experienced (1) concerted evolutionary responses to past geological and climatic events, indicated by congruent spatial and temporal patterns ("concerted-response hypothesis"); (2) independent responses, indicated by spatial incongruence ("independent-response hypothesis"); or (3) multiple responses ("multiple-response hypothesis"), indicated by spatial congruence but temporal incongruence ("pseudocongruence") or spatial and temporal incongruence ("pseudoincongruence"). We tested these competing hypotheses using DNA sequence data from three livebearing fish species codistributed in the Nicaraguan depression of Central America (Alfaro cultratus, Poecilia gillii, and Xenophallus umbratilis) that we predicted might display congruent responses due to co-occurrence in identical freshwater drainages. Spatial analyses recovered different subdivisions of genetic structure for each species, despite shared finer-scale breaks in northwestern Costa Rica (also supported by phylogenetic results). Isolation-with-migration models estimated incongruent timelines of among-region divergences, with A. cultratus and Xenophallus populations diverging over Miocene-mid-Pleistocene while P. gillii populations diverged over mid-late Pleistocene. Approximate Bayesian computation also lent substantial support to multiple discrete divergences over a model of simultaneous divergence across shared spatial breaks (e.g., Bayes factor [B 10] = 4.303 for Ψ [no. of divergences] > 1 vs. Ψ = 1). Thus, the data support phylogeographic pseudoincongruence consistent with the multiple-response hypothesis. Model comparisons also indicated incongruence in historical demography, for example, support for intraspecific late Pleistocene population growth was unique to P. gillii, despite evidence for finer-scale population expansions in the other taxa. Empirical tests for phylogeographic congruence indicate that multiple

  1. Nyheder i Japan

    DEFF Research Database (Denmark)

    Sejrup, Jens

    2016-01-01

    Kan man stole på, hvad folk siger, når man ikke ved, hvem de er? Forholdet mellem kildeanonymitet og troværdighed er forskelligt i mediesystemer rundt om i verden. Troværdighed er ingen universel størrelse, men en retorisk effekt der opstår på baggrund af faktorer som er kulturelt og systemisk in...... indlejret. I Japan har seriøse nyhedsmedier et specielt forhold til udsagn fra anonyme kilder, og udstrakt brug af uidentificerede informanter står ikke i modsætning til journalistisk kvalitet og pålidelighed....

  2. Gems of japanized English

    CERN Document Server

    Kenrick, Miranda

    2011-01-01

    If you've ever had the uneasy feeling that the Japanese do things better, this book may be the ideal antidote. Even the Japanese are quick to admit that despite their enthusiasm for learning it, they still have a certain amount of difficulty with the English language. This is no new phenomenon. Shortly after Japan opened her ports to foreign traders, one doctor advertised himself as ""a Specialist in the Decease of Children""; eggs were sold as ""extract of fowl""; and a notice advised that ""Tomorrow, from midnight to 12 noon, you will receive dirty water."" Fortunately, things are improving,

  3. The central hemodynamics special features of sportsmen with a glance to changes in heart rate variability as the response on the training loads

    Directory of Open Access Journals (Sweden)

    Оксана Володимирівна Гузій

    2015-12-01

    Full Text Available Aim: to analyze indices of the central hemodynamics of highly qualified sportsmen at rest taking into account HF-components of heart-rhythm variability after training loads.Methods of research. To study the special features of the central hemodynamics there was used spiroarteriocardiorythmography (SACR that allows to detect in the regimen of momentary registration indices that characterize heart activity (according to ECG data in the first lead, vessels (systolic arterial pressure (SAP and diastolic arterial pressure DAP on the middle phalanx of the finger by Penaz method, respiratory system (according to an ultrasound spirometry data. Statistical analysis was carried out using nonparametric methods with determination of Mann-Whitney criterion.Results. The study of influence of training loads in the period before competitions allowed to establish that after training load in several sportsmen were noticed the low values of HF-component of HRV(58,1%, and in other ones the values of HF-components of HRV were in the limits of population norm (38,7%. This fact indicated the differences of HRV responses in different sportsmen that further formed two groups of research ЕG1 and ЕG2.An analysis of central hemodynamics demonstrated that in most sportsmen from ЕG1 (88,2% and ЕG2 (64% was noticed the hypokinetic type of blood circulation. Hyperkinetic type of blood circulation was not registered in any group. The comparison of separate indices of central hemodynamic demonstrated that final diastolic volume (FDV, final systolic volume (FSV and momentary volume of blood (MVB are reliably higher in experimental group (ЕG2 (р < 0,01. In ЕG1 was noticed the reliably more peripheral resistivity of vessels (PRV (р < 0,05.Conclusion. The study of central hemodynamics in groups of sportsmen whose response on training loads differed on the level of high-frequency component activity of the heart rate variability allowed establish that these changes are

  4. Real-time detection of central carbon metabolism in living Escherichia coli and its response to perturbations.

    Science.gov (United States)

    Meier, Sebastian; Jensen, Pernille R; Duus, Jens Ø

    2011-10-03

    The direct tracking of cellular reactions in vivo has been facilitated with recent technologies that strongly enhance NMR signals in substrates of interest. This methodology can be used to assay intracellular reactions that occur within seconds to few minutes, as the NMR signal enhancement typically fades on this time scale. Here, we show that the enhancement of (13)C nuclear spin polarization in deuterated glucose allows to directly follow the flux of glucose signal through rather extended reaction networks of central carbon metabolism in living Escherichia coli. Alterations in central carbon metabolism depending on the growth phase or upon chemical perturbations are visualized with minimal data processing by instantaneous observation of cellular reactions.

  5. Safety Concerns of Tourism Business in Japan

    Directory of Open Access Journals (Sweden)

    Irina P. Karavaeva

    2012-05-01

    Full Text Available The article is focused on the current state of tourism industry in Japan after the nuclear disaster of 2011. A focus is made on networking activities of Japan Government aimed at boosting leisure travel flows to Japan.

  6. Analysis Of Japans Economy Based On 2014 From Macroeconomics Prospects

    Directory of Open Access Journals (Sweden)

    Dr Mohammad Rafiqul Islam

    2015-02-01

    Full Text Available Abstract Japan is the worlds third largest economy. But currently economic situations of Japan are not stable. It is not increasing as expected. Since 2013 it was world second largest economy but Japan loosed its placed to China in 2014 due to slow growth of important economic indicators. By using the basic Keynesian model we will provide a detailed analysis of the short and long run impacts of the changes for Japans real GDP rate of unemployment and inflation rate. We demonstrated a detailed use of the 45-degree diagram or the AD-IA model and other economic analysis of the macroeconomic principles that underlie the model and concepts. Finally we will recommend the government with a change in fiscal policy what based on the analysis by considering what might be achieved with a fiscal policy response and the extent to which any impact on the stock of public debt might be a consideration

  7. 21 CFR 186.1555 - Japan wax.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Japan wax. 186.1555 Section 186.1555 Food and Drugs... Substances Affirmed as GRAS § 186.1555 Japan wax. (a) Japan wax (CAS Reg. No. 8001-39-6), also known as Japan... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan...

  8. Strong congruence in tree and fern community turnover in response to soils and climate in central Panama

    DEFF Research Database (Denmark)

    Jones, Mirkka; Ferrier, Simon; Condit, Richard

    2013-01-01

    1. Plant species turnover in central Panamanian forests has been principally attributed to the effects of dispersal limitation and a strong Caribbean to Pacific gradient in rainfall seasonality. Despite marked geological heterogeneity, the role of soil variation has not been rigorously examined. 2...

  9. Anti-gang policies and gang responses in the Northern Triangle : The Evolution of the Gang Phenomenon in Central America

    NARCIS (Netherlands)

    van der Borgh, G.J.C.; Savenije, W.

    2014-01-01

    During the past decade, gangs have become a powerful and violent presence in El Salvador, Guatemala and Honduras, the ‘Northern Triangle’ of Central America. 1 The particular evolution of the gang phenomenon has been deeply shaped by a series of reactions and adaptations to ill-developed security po

  10. Summer cooling in the east central Arabian Sea - a process of dynamic response to the southwest monsoon

    Digital Repository Service at National Institute of Oceanography (India)

    RameshBabu, V.; Sastry, J.S.

    The cooling of the east central Arabian Sea during summer monsoon season is examined using data sets of MONEX '79 and MONSOON '77 programmes. These studies have revealed that downward transfer of heat due to the mixing of warm surface and cold sub...

  11. Wound response and ROS production in blue mold resistant wild apple germplasm from Kazakhstan and central Asia

    Science.gov (United States)

    Blue mold caused by Penicillium expansum is the most destructive pathogen of stored apples in the US and worldwide. It was recently shown that resistance to blue mold exists in wild apples, Malus sieversii, from Kazakhstan and central Asia maintained in a germplasm collection in Geneva, NY. We ini...

  12. Toxicokinetics in Japan

    Institute of Scientific and Technical Information of China (English)

    HakuH

    2002-01-01

    The word ‘toxicokinetics’ is a comparatively new word,but it was being generally practiced in Japanese pharmaceutical industry over 6 years ago.Note for guidance on toxicokinetics(ICH S3A):the assessment of systemic exposure in toxicity studies was harmonized internationally and was essential as the data package for the NDA of a new drug in Japan since 1996.Toxicokinetics is a combination of toxicology and pharmacokinetics.It was to develop a tool which could be most helpful in the interpretation of toxicity data.Using “exposure” as indicated by AUC and/or cmax for parent drug or major metabolite in laboratory animals and man,one can calculate a human safety margin.This human safety margin is the ratio of the AUC of the “no effect dose” in animals in the toxicology studies to the AUC to the therapeutic dose in man.I would like to introduce the actual practice of toxicolinetics in Japan.

  13. Nutrition trends in Japan.

    Science.gov (United States)

    Matsumura, Y

    2001-01-01

    The National Nutrition Survey (NNS) in Japan has been undertaken annually since 1946. It was originally intended to provide information on the food and nutrient intake of the Japanese people, with a view to acquiring emergency food supplies from other countries when food shortages caused malnutrition in many Japanese. The food balance sheet (FBS) has been drawn up since 1949 to show the food supply available to the Japanese people. The trends and figures shown by both approaches were similar until the mid-1970s. Since then, however, the disparity between the food supply and the intake of foods and nutrients has been getting larger. National food security means that a country has enough food for everyone. This does not mean, however, that every family has enough food, because the food may not be evenly distributed. In fact, marginal deficiencies in iron and calcium are thought to still exist and there is considerable variation among households in energy intake. In Japan, nutrition and diet are now considered to play important roles in the emerging problems of obesity, diabetes mellitus, hypertension etc., because of excessive energy intake and deficiency or excessive intake of certain nutrients.

  14. Legalized Abortion in Japan

    Science.gov (United States)

    Hart, Thomas M.

    1967-01-01

    The enactment of the Eugenic Protection Act in Japan was followed by many changes. The population explosion was stemmed, the birth rate was halved, and while the marriage rate remained steady the divorce rate declined. The annual total of abortions increased until 1955 and then slowly declined. The highest incidence of abortions in families is in the 30 to 34 age group when there are four children in the family. As elsewhere abortion in advanced stages of pregnancy is associated with high morbidity and mortality. There is little consensus as to the number of criminal abortions. Reasons for criminal abortions can be found in the legal restrictions concerning abortion: Licensing of the abortionist, certification of hospitals, taxation of operations and the requirement that abortion be reported. Other factors are price competition and the patient's desire for secrecy. Contraception is relatively ineffective as a birth control method in Japan. Oral contraceptives are not yet government approved. In 1958 alone 1.1 per cent of married women were sterilized and the incidence of sterilization was increasing. PMID:6062283

  15. Teaching Elementary Students about Japan

    Science.gov (United States)

    Fitzhugh, William P.

    This paper presents a study unit on Japan for elementary students which can be adapted for any level. Lessons include: (1) "Video Traveling Activities To Accompany Students on Their Journey to Japan"; (2) "Travel Brochure"; (3) "Discovering Culture by Using a Realia Kit"; (4) "Comparative Geography Using the Five Fundamental Themes of Geography";…

  16. Studying Japan: The Cooperative Way.

    Science.gov (United States)

    Hilke, Eileen

    1990-01-01

    Designs an elementary level social studies unit with the focus on Japan. Provides sample units of cooperative learning group projects. Suggests integrating mathematics, language arts, economics, fine arts, and science. Lists resources for obtaining more information and materials about Japan. (NL)

  17. [The small halophilic zygopteric odonate, Mortonagrion hirosei, of central Japan, a predator utilizable against tiny stinging diptera of coastal salt marshes, especially Ceratopogonidae of the genera Culicoides and Oecacta, pests of sea shores in southwestern U.S.A. and Caribbean area].

    Science.gov (United States)

    Vasserot, J

    1986-01-01

    Among stinging diptera pullulating in coastal salt marshes Ceratopogonidae gnats (mainly of genus Culicoides and Oecacta) are especially troublesome, particularly in Southeastern U. S. A. and Caribbean area, escaping attacks of most predators by their tiny size. But the zygopteric odonate insect Mortonagrion hirosei is well fitted for hunting those minute diptera, by its tiny size and its behaviour, seeking shelter between halophilic plants (2 facts explaining that it was not discovered in central Japan before 1971...). Its larvae, living in brackish waters of coastal lagoons, can devour those of Ceratopogonidae and at least young stages of those of Mosquitoes whose some halophilic species are dangerous vectors of diseases. According to similarity of climates M. hirosei can certainly thrive in Southeastern U. S. A., and probably in Southern Europe. At lower latitudes problems for completion of annual cycle could perhaps arise from lack of hivernal cooling. It is necessary to make at the world scale methodical researches for other species of zygopteric odonates of similar ecology which could exist in other countries, both for avoiding harmful competition of introduced M. hirosei with native species still unknown and for fulfilling the same ecological function in areas of climate no suitable for this Japanese insect. Introduction of M. hirosei in new geographic areas would be very useful, too, for protection of this interesting species threatened by human activities in its natural biotopes, made of discontinuous and rather little areas.

  18. Towards better understanding of the response of Sphagnum peatland to increased temperature and reduced precipitation in Central Europe

    Science.gov (United States)

    Juszczak, Radoslaw; Basińska, Anna; Chojnicki, Bogdan; Gąbka, Maciej; Hoffmann, Mathias; Józefczyk, Damian; Lamentowicz, Mariusz; Leśny, Jacek; Łuców, Dominika; Moni, Christophe; Reczuga, Monika; Samson, Mateusz; Silvennoinen, Hanna; Stróżecki, Marcin; Urbaniak, Marek; Zielińska, Małgorzata; Olejnik, Janusz

    2017-04-01

    temperature, methane emissions were positively correlated with LAI of vascular plants, which was higher at the warmer sites during both years. Despite of being a net sink for CO2 during both years, the NEE was five times smaller for all sites (-100 gCṡm-2yr-1) during the dry 2015 year compared to 2016. The highest CO2 emissions were measured for the site with increased temperature (W site, Reco 780 gCṡm-2yr-1). Temperature increase also provoked the productivity - GPP was the highest at W site. While the smallest CO2 emissions and GPP were recorded on the site exposed to reduced precipitation. This emphasizes the importance of drought in inhibiting respiration and carbon uptake by plants. Despite of a higher productivity, NEE was smaller on W and W+D, due to higher CO2 effluxes. As a result of the drier conditions in 2015, the GWP of all sites was positive, showing the highest values for the temperature increased sites. Compared to that, GWP was negative for all sites besides those exposed to drought during the more wet year 2016. Different vegetation parameters further support the C exchange estimates. In general, warmer and drier conditions led to an increased LAI, whilst the site only exposed to drought exhibited the lowest NDVI. In addition, increased temperatures shifted the vegetation species composition by promoting vascular plants (mainly Carex rostrata and C. limosa), which correlates positively with nutrient (Ptot, Mn, F, Na, Zn) availability in the ground water. We report short-term responses of peatland to increased temperature and reduced precipitation, showing that the combination of these to stressors are leading to very different scenarios, regardless of their individual impacts. Thus our results emphasize the need for long term records from full-factorial field manipulation sites on peatland response to climate changes. The Research was co-founded by the Polish National Centre for Research and Development within the Polish-Norwegian Research Programme

  19. Negative Energy Balance Blocks Neural and Behavioral Responses to Acute Stress by “Silencing” Central Glucagon-Like Peptide 1 Signaling in Rats

    Science.gov (United States)

    Maniscalco, James W.; Zheng, Huiyuan; Gordon, Patrick J.

    2015-01-01

    Previous reports indicate that caloric restriction attenuates anxiety and other behavioral responses to acute stress, and blunts the ability of stress to increase anterior pituitary release of adrenocorticotropic hormone. Since hindbrain glucagon-like peptide-1 (GLP-1) neurons and noradrenergic prolactin-releasing peptide (PrRP) neurons participate in behavioral and endocrine stress responses, and are sensitive to the metabolic state, we examined whether overnight food deprivation blunts stress-induced recruitment of these neurons and their downstream hypothalamic and limbic forebrain targets. A single overnight fast reduced anxiety-like behavior assessed in the elevated-plus maze and acoustic startle test, including marked attenuation of light-enhanced startle. Acute stress [i.e., 30 min restraint (RES) or 5 min elevated platform exposure] robustly activated c-Fos in GLP-1 and PrRP neurons in fed rats, but not in fasted rats. Fasting also significantly blunted the ability of acute stress to activate c-Fos expression within the anterior ventrolateral bed nucleus of the stria terminalis (vlBST). Acute RES stress suppressed dark-onset food intake in rats that were fed ad libitum, whereas central infusion of a GLP-1 receptor antagonist blocked RES-induced hypophagia, and reduced the ability of RES to activate PrRP and anterior vlBST neurons in ad libitum-fed rats. Thus, an overnight fast “silences” GLP-1 and PrRP neurons, and reduces both anxiety-like and hypophagic responses to acute stress. The partial mimicking of these fasting-induced effects in ad libitum-fed rats after GLP-1 receptor antagonism suggests a potential mechanism by which short-term negative energy balance attenuates neuroendocrine and behavioral responses to acute stress. SIGNIFICANCE STATEMENT The results from this study reveal a potential central mechanism for the “metabolic tuning” of stress responsiveness. A single overnight fast, which markedly reduces anxiety-like behavior in rats

  20. A remarkable sea-level drop and relevant biotic responses across the Guadalupian-Lopingian (Permian) boundary in low-latitude mid-Panthalassa: Irreversible changes recorded in accreted paleo-atoll limestones in Akasaka and Ishiyama, Japan

    Science.gov (United States)

    Kofukuda, Daisuke; Isozaki, Yukio; Igo, Hisayoshi

    2014-03-01

    The Capitanian (Upper Guadalupian) to Wuchiapingian (Lower Lopingian) shallow-marine limestones at Akasaka and Ishiyama in central Japan record unique aspects of the extinction-related Guadalupian-Lopingian boundary (G-LB) interval. The ca. 140 m-thick Akasaka Limestone consists of the Capitanian black limestone (Unit B; 112 m) and the Wuchiapingian light gray dolomitic limestone (Unit W; 21 m), with a black/white striped limestone (Unit S; 9 m) between them. The G-LB horizon is assigned at the base of Unit W, on the basis of the first occurrence of the Wuchiapingian fusulines. The Capitanian Unit B and the Wuchiapingian Unit W were deposited mostly in the subtidal zone of a lagoon, whereas the intervened Unit S and the lowermost Unit W were in the intertidal zone. A hiatus with a remarkable erosional feature was newly identified at the top of Unit S. These records indicate that the sea-level has dropped significantly around the G-LB to have exposed the top of the atoll complex above the sea-level. The Ishiyama Limestone, located ca. 10 km to the north of the Akasaka limestone, retains almost the same depositional records. The extinction of large-tested fusuline (Yabeina) and large bivalves (Alatoconchidae) occurred in the upper part of Unit B, and the overlying 20 m-thick limestone (the uppermost Unit B and Unit S) below the hiatus represents a unique barren interval. The upper half of the barren interval is more depleted in fossils than the lower half, and this likely represents a duration of the severest environmental stress(es) for the shallow-marine protists/animals on the mid-oceanic paleo-atoll complex. Small-tested fusulines re-appeared at the base of Unit W above the hiatus. These facts prove that the elimination of shallow-marine biota occurred during the Capitanian shallowing of Akasaka paleo-atoll before the subaerial exposure/erosion across the G-LB. The overall shallowing and the development of such a clear hiatus at the top of a mid-oceanic seamount

  1. Quantification of fluvial response to tectonic deformation in the Central Pontides, Turkey; inferences from OSL dating of fluvial terraces

    Science.gov (United States)

    McClain, Kevin; Yıldırım, Cengiz; Çiner, Attila; Akif Sarıkaya, M.; Şahin, Sefa; Özcan, Orkan; Güneç Kıyak, Nafiye; Öztürk, Tuǧba

    2017-04-01

    From Late Miocene to present, Anatolia's rapid counterclockwise movement, which increases in velocity towards the Hellenic Arc, has formed the North Anatolian Fault (NAF), a dextral transform fault along the Anatolia-Eurasia plate boundary and the northern margin of the Central Anatolian Plateau (CAP). A zone of transpression referred to as the Central Pontides exists between the broad restraining bend of the NAF and the Black Sea Basin, uplifting what is interpreted as a detached flower structure. Dating of Quaternary landforms in the eastern flank of the Central Pontides has helped to understand its recent deformation. However, in the western flank of the Central Pontides there is an absence of Quaternary studies, relatively quiet modern seismicity, and difficulties locating or observing fault scarps. This led us to use optically stimulated luminescence dating (OSL-dating) of fluvial terrace sediments and the study of geomorphic features to gain insight into the influence of climate and tectonics on landscape evolution of this area. In this area, the Filyos River crosses the Karabük Fault (reverse fault) and deeply incises a gorge through the Karabük Range before flowing towards the Black Sea. In the gorge an abundance of indicators of tectonic deformation were mapped, such as hanging valleys, wind gaps, bedrock gorges, landslides, steep V-shaped channels, tilted basins, as well as fluvial strath terraces. In particular, strath terraces of at least 8 levels within just 1.5 km of horizontal distance were examined. We used OSL-dating to estimate five deposition ages of fluvial strath terrace sediments, leading to an estimation of incision and uplift rates over time. Using three samples per terrace with strath elevations of 246 ± 0.2 m, 105.49 ± 0.2 m, 43.6 ± 0.2 m, 15.3 ± 0.2 m and 3.6 ± 0.2 m above the Filyos River, we determined corresponding ages of 841 ± 76 ka, 681 ± 49 ka, 386 ± 18 ka, 88 ± 5.1 ka and 50.9 ± 2.8 ka. Incision rates over time (oldest

  2. CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells.

    Science.gov (United States)

    Trifilo, Matthew J; Montalto-Morrison, Cynthia; Stiles, Linda N; Hurst, Kelley R; Hardison, Jenny L; Manning, Jerry E; Masters, Paul S; Lane, Thomas E

    2004-01-01

    How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating innate immune responses. Herein, we evaluated the contributions of CXC chemokine ligand 10 (CXCL10) in promoting innate defense mechanisms following coronavirus infection of the CNS. Intracerebral infection of RAG1(-/-) mice with a recombinant CXCL10-expressing murine coronavirus (mouse hepatitis virus) resulted in protection from disease and increased survival that correlated with a significant increase in recruitment and activation of natural killer (NK) cells within the CNS. Accumulation of NK cells resulted in a reduction in viral titers that was dependent on gamma interferon secretion. These results indicate that CXCL10 expression plays a pivotal role in defense following coronavirus infection of the CNS by enhancing innate immune responses.

  3. Systematic review including re-analyses of 1148 individual data sets of central venous pressure as a predictor of fluid responsiveness

    DEFF Research Database (Denmark)

    Eskesen, T G; Wetterslev, M; Perner, A

    2016-01-01

    PURPOSE: Central venous pressure (CVP) has been shown to have poor predictive value for fluid responsiveness in critically ill patients. We aimed to re-evaluate this in a larger sample subgrouped by baseline CVP values. METHODS: In April 2015, we systematically searched and included all clinical...... studies evaluating the value of CVP in predicting fluid responsiveness. We contacted investigators for patient data sets. We subgrouped data as lower (12 mmHg) baseline CVP. RESULTS: We included 51 studies; in the majority, mean/median CVP values were...... in which the lower 95 % CI crossed 0.50. We identified some positive and negative predictive value for fluid responsiveness for specific low and high values of CVP, respectively, but none of the predictive values were above 66 % for any CVPs from 0 to 20 mmHg. There were less data on higher CVPs...

  4. Japan's BSE program

    Science.gov (United States)

    Imai, N.; Matsushita, M.; Kajikawa, M.

    1982-12-01

    An overview of the program for Japan's Medium-scale Broadcasting Satellite for Experimental Purpose (BSE), placed in orbit in 1978, is presented. The BSE was developed in order to provide useful technical data for establishing the fundamental technology of satellite broadcasting systems, the controlling and operational techniques of the broadcasting satellite, and the reception of broadcasting satellite radio waves. The satellite system and the ground facilities are discussed, and tables are included which list the system parameters and subsystems of the BSE. In addition, an outline is presented of the various experiments conducted utilizing the BSE, including the evaluation of the broadcasting service area, the transmission methods and their characteristics, controlling technique of the satellite, multiple access from different stations, and the improvement of receiving systems

  5. Radiation processing in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Makuuchi, Keizo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    2001-03-01

    Economic scale of radiation application in the field of industry, agriculture and medicine in Japan in 1997 was investigated to compare its economic impacts with that of nuclear energy industry. Total production value of radiation application accounted for 54% of nuclear industry including nuclear energy industry and radiation applications in three fields above. Industrial radiation applications were further divided into five groups, namely nondestructive test, RI instruments, radiation facilities, radiation processing and ion beam processing. More than 70% of the total production value was brought about by ion beam processing for use with IC and semiconductors. Future economic prospect of radiation processing of polymers, for example cross-linking, EB curing, graft polymerization and degradation, is reviewed. Particular attention was paid to radiation vulcanization of natural rubber latex and also to degradation of natural polymers. (S. Ohno)

  6. Trauma and posttraumatic stress disorder in Japan: results from the World Mental Health Japan Survey.

    Science.gov (United States)

    Kawakami, Norito; Tsuchiya, Masao; Umeda, Maki; Koenen, Karestan C; Kessler, Ronald C

    2014-06-01

    The purpose of the study was to report the prevalence of trauma exposure and PTSD, conditional risk of PTSD associated with each trauma exposure in the community population in Japan. An interview survey was conducted of a random sample of adult residents in 11 communities of Japan. Among 4134 respondents (response rate, 55%), data from those who completed the part 2 interview (n = 1682) were analyzed with a weight for this subsample. Lifetime experiences of 27 trauma events and PTSD were assessed using the WHO-Composite International Diagnostic Interview version 3.0. Sixty percent of the part 2 sample reported exposure to at least one lifetime traumatic event. Lifetime and 12-month PTSD prevalences were 1.3% and 0.7%, respectively. Percentage of all months lived with PTSD in the population was predominantly accounted for by physical/sexual assaults and having a child with serious illness, and unexpected death of loved one. Ten percent of respondents reported "private events", for which respondents did not have to describe the content, which accounted for 19% of months with PTSD. The lower prevalence of PTSD in Japan seems attributable to lower conditional risks of PTSD following these events, as well as different distributions of the events. The greater impact of events that occurred to loved ones rather than to oneself and "private events" on PTSD in Japan warrants further research of cross-cultural assessment of trauma exposure and cultural heterogeneity in the trauma-PTSD relationship.

  7. How Operations in Haiti and Japan Informed Joint Publication 3-08: The Future of Interorganizational Operations?

    Science.gov (United States)

    2013-05-23

    Assistance, Japan Earthquake and Tsunami Update ( Tripler Army Medical Center, Hawaii, 2011), 42. 51Karl C. Rohr, Operation Tomodachi: After Action...Humanitarian Assistance. Japan Earthquake and Tsunami Update. Tripler Army Medical Center, Hawaii, 2011. Central Intelligence Agency, "CIA Fact Book" https

  8. Academic Profession's Challenge to the Construction of Educational Management in Japan. RIHE International Seminar Reports. No. 23

    Science.gov (United States)

    Arimoto, Akira

    2015-01-01

    Active learning is now gradually being adopted in many universities and colleges in Japan. This follows the release of the 2012 Central Council of Education (CCE) report that emphasized the need to introduce active learning and to reinforce educational management in academia. As a result, one of the most important problems in Japan's higher…

  9. Lack of correlation between the ventilatory response to CO2 and lung function impairment in myotonic dystrophy patients: evidence for a dysregulation at central level.

    Science.gov (United States)

    Poussel, Mathias; Thil, Catherine; Kaminsky, Pierre; Mercy, Magalie; Gomez, Emmanuel; Chaouat, Ari; Chabot, François; Chenuel, Bruno

    2015-05-01

    Myotonic dystrophy Type 1 (DM1) is the most common muscular dystrophy in adults. Respiratory failure is common but clinical findings support a dysregulation of the control of breathing at central level, furthermore contributing to alveolar hypoventilation independently of the severity of respiratory weakness. We therefore intended to study the relationship between the ventilatory response to CO2 and the impairment of lung function in DM1 patients. Sixty-nine DM1 patients were prospectively investigated (43.5 ± 12.7 years). Systematic pulmonary lung function evaluation including spirometry, plethysmography, measurements of respiratory muscle strength, arterial blood gas analysis and ventilatory response to CO2 were performed. Thirty-one DM1 patients (45%) presented a ventilatory restriction, 38 (55%) were hypoxaemic and 15 (22%) were hypercapnic. Total lung capacity decline was correlated to hypoxaemia (p = 0.0008) and hypercapnia (p = 0.0013), but not to a decrease in ventilatory response to CO2 (p = 0.194). Ventilatory response to CO2 was reduced to 0.85 ± 0.67 L/min/mmHg and not correlated to respiratory muscle weakness. Ventilatory response to CO2 was neither different among restricted/non-restricted patients (p = 0.2395) nor among normoxaemic/hypoxaemic subjects (p = 0.6380). The reduced ventilatory response to CO2 in DM1 patients appeared independent of lung function impairment and respiratory muscle weakness, suggesting a central cause of CO2 insensitivity.

  10. Japan (country/area statements).

    Science.gov (United States)

    1985-09-01

    Japan, a country generally successful in solving population problems, now faces the problem of an aging population. It must provide welfare for its aged population and give them a role in society. Recognizing the vital importance to economic and social development of population problems in developing countries, Japan has cooperated through bilateral and multilateral channels in assisting various projects of developing countries concerned about population problems. As for bilateral aid, Japan extends technical cooperation to Economic and Social Commission for Asia and the Pacific (ESCAP) region countries by providing them with experts, by conducting surveys, by giving equipment, and by organizing training courses, particularly in the field of family planning. Japan also cooperates with some of the developing countries of the ESCAP region by providing them with financial assistance in the form of multilateral cooperation. Japan makes a cash contribution the the UN Fund for Population Activities (UNFPA) as the biggest donor country. In fiscal year 1984, the Japanese contribution to UNFPA totaled $US 40.1 million; the contribution will amount of $US 42.9 million in 1985. Aware of the importance of human resource development in the field of population, Japan has organized annual group training courses for the developing countries, namely: the Seminar on Family Planning Administration for Senior Officers; the Seminar on Community-Based Family Planning Strategy; and the Seminar on Health Aspects of Family Planning. Japan generally supports the work of ESCAP with regard to training in the field of population.

  11. Central pain.

    Science.gov (United States)

    Singh, Supreet

    2014-12-01

    Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. The topic addressed in this issue is central pain, a neuropathic pain syndrome caused by a lesion in the brain or spinal cord that sensitizes one's perception of pain. It is a debilitating condition caused by various diseases such as multiple sclerosis, strokes, spinal cord injuries, or brain tumors. Varied symptoms and the use of pharmacological medicines and nonpharmacological therapies will be addressed.

  12. Multiple personality disorder in Japan.

    Science.gov (United States)

    Fujii, Y; Suzuki, K; Sato, T; Murakami, Y; Takahashi, T

    1998-06-01

    The aim of this study was to determine whether the features of multiple personality disorder (MPD) in Japan are similar to those in North America, although a wide disparity exists in the prevalence of MPD between the two areas. In order to describe the features of MPD in Japan, we obtained clinical data from MPD case reports, including two of our own cases, published in Japanese academic journals and compared it with the data from other countries. The cases in Japan differed significantly from those in North America in the mean number of personalities and prevalence of sexual and/or physical abuse.

  13. Amaranthus cruentus L. is suitable for cultivation in Central Italy: field evaluation and response to plant densities

    Directory of Open Access Journals (Sweden)

    Paolo Casini

    2014-12-01

    Full Text Available The aim of this study was to determine the possibility of amaranth cultivation in Central Italy and to determine the optimum plant density. Field trials were carried out in 2011 and 2012 under non-irrigated conditions in Tuscany (43° 18’ N, 11° 47’ E. Twelve accessions of two amaranth species (Amaranthus cruentus L. and A. hypochondriacus L. were utilised. Genotypes were evaluated over a two-year period using a RCB design with three replicates. The effects of plant density were investigated in 2012. A with a split-plot design was used, where the A. cruentus accessions (AMES 5148, PI 511719 and PI 643045 constituted the main plots. Plant densities (7.5, 15, 30 and 60 plants m–2 constituted the subplots. Plants were transplanted at the 3-4 true leaf stage. Morphological traits were determined using 5 plants selected from the two central rows of the sampling area. Plots were hand-harvested and cleaned with a mechanical grid with appropriate sieve diameters. A. cruentus was shown to be more suitable to the Central Italy agro-ecological conditions than A. hypochondriacus. The accessions derived from Mexico (PI 477913, PI 576481, PI 643045, PI 643053, and PI 6495079, Guatemala (PI 511719 and Puerto Rico (AMES 5148, had both higher grain yields and a greater stability over the two-year period, with a mean grain production ranging from 2.8 to 3.2 t ha–1. The severe climatic stress in 2012 (high temperatures and aridity, resulted in a 43-60% reduction in seed production compared to that of the previous year. Under these conditions, PI 511719, AMES 26015, AMES 5386, AMES 5148, PI 477913 yielded on average 1.9 t ha–1. Yields of A. hypochondriacus were negligible in both years, probably attributable to greater photoperiod sensitivity, resulting in reduced flowering and delayed maturity. By increasing density up to 60 and 30 plants m–2 for PI 511719 and AMES 5148, respectively, grain production was increased by 55%. As the plant population

  14. Optimization of electrospinning process of poly(vinyl alcohol via response surface methodology (RSM based on the central composite design

    Directory of Open Access Journals (Sweden)

    Mina Yazdanpanah

    2014-06-01

    Full Text Available Evaluating the capability of electrospinning method as an efficient versatile approach for fabrication of fibers, a central composite design (CCD model was used to design an experimental program for investigation of effective in production of poly (vinyl alcohol (PVA fibers fabricated from aqueous solutions of PVA. The studied variables were polymer solution concentration, applied voltage, distance between nozzle and collector plate and flow rate of solution injection. The influence of these parameters on diameter and morphology of obtained PVA fibers was studied by SEM analysis. Among all factors, concentration would strongly affect the fiber diameter.

  15. Romanticising Shinsengumi in Contemporary Japan

    Directory of Open Access Journals (Sweden)

    Rosa Lee

    2011-01-01

    Full Text Available Shinsengumi, a group of young men recruited by the Bakufu to protect Kyoto from radical Imperial House loyalists in the tumultuous Bakumatsu period, is romanticised and idolised in Japan despite its limited place in history. This article attempts to comprehend this phenomenon by locating the closest crystallisation of popularly imagined Shinsengumi in Moeyo ken, a popular historical fiction by Shiba Ryōtarō. Antonio Gramsci explains readers are attracted to popular literature because it reflects their ‘philosophies of the age’, which may be discovered by examining popular heroes with their subsequent replications. This article will identify why Shinsengumi is appealing by comparing Shiba’s hero in Moeyo ken with its twenty-first century reincarnation in Gintama, a popular manga series, and by discerning reader response to Moeyo ken from customer reviews on Amazon.co.jp. It will be demonstrated from these studies that a likely reason for the Japanese public’s romanticisation of Shinsengumi in recent years could be their attraction to autonomous, self-determining heroes who also appreciate the value of community.

  16. Japan, Indonesia to investigate condom plant feasibility.

    Science.gov (United States)

    1981-04-01

    The Japanese government has begun investigations on the possibility of constructing a condom manufacturing plant in Indonesia in response to a request by the Indonesian government. Indonesia, which hopes to reduce its birthrate as of 1971 by 1/2 by 1990, asked for Japanese assistance in building a condom plant based on the expectation that demand for this contraceptive method, although quite low at present, will increase rapidly in the near future with stepped-up motivation campaigns. As a 1st step in the investigation, the Japan International Cooperation Agency (JICA) sent a study team of family planning experts headed by Family Planning Federation of Japan Chairman Dr. Hidebumi Kubo and including JOICFP International Division Director MR. Tameyoshi Katagiri to Indonesia from March 15-24. During its visit, the JICA team held discussions with representatives of BKKBN (the National Family Planning Coordinating Board) including its Chairman and Minister of Health Dr. Suwardjono and reached agreement on the scope and schedule of work toward determining the feasibility of building and operating a condom plant in Indonesia. In defining the scope of work and the schedule, the JICA team and the BKKBN representatives decided on specific issues to be investigated in the feasibility study to be carried out by JICA and scheduled to be completed by the end of October of this year. To be included in the feasibility study are: estimation of future domestic demand for condoms, examination of the domestic supply of latex capacity, chemicals and packaging materials, and collection of information on infrastructure relating to water, energy, transportation, etc. Actual data collection for the study is expected to begin in late May or early June. Dr. Kubo and Mr. Katagiri, upon returning to Japan, reported great enthusiasm for the project in Indonesia and expressed the hope that the plant construction will be feasible so that the country's family planning program can be given a boost

  17. Occupational stress among healthcare workers in Japan.

    Science.gov (United States)

    Ito, Shinya; Fujita, Shigeru; Seto, Kanako; Kitazawa, Takefumi; Matsumoto, Kunichika; Hasegawa, Tomonori

    2014-01-01

    High distress levels in healthcare workers in Japan may deteriorate safe service provision. To clarify job stress of healthcare workers, we compared Brief Job Stress Questionnaire (BJSQ) scores among physicians, nursing staff and administrative workers. Healthcare workers (n=9,137) in 20 hospitals in Japan were asked to answer BJSQ. BJSQ is job stress questionnaire to measure "Job Stressors", "Stress Responses" and "Social Supports". The "Total Health Risk" of the healthcare workers was 10% higher than the national average. While the physicians felt the stress of the quantitative and qualitative job overload, they had support from supervisors and coworkers and showed mild "Stress Responses". The nursing staff felt the stress of the quantitative and qualitative job overload at the same level as the physicians, but they did not have sufficient support from supervisors and coworkers, and showed high "Stress Responses". The administrative workers did not have sufficient support from supervisors and coworkers, but they experienced less stress as measured by the quantitative and qualitative job overload than the physicians or the nursing staff and showed moderate "Stress Responses". Further studies are needed to clarify the mechanisms and the influence of other factors to the stress trait in healthcare workers.

  18. Can wolves help save Japan's mountain forests?

    Science.gov (United States)

    Barber-meyer, Shannon

    2017-01-01

    Japan’s wolves were extinct by 1905. Today Japan's mountain forests are being killed by overabundant sika deer and wild boars. Since the early 1990s, the Japan Wolf Association has proposed wolf reintroduction to Japan to restore rural ecology and to return a culturally important animal. In this article I discuss whether the return of wolves could help save Japan's mountain forests.

  19. Teaching about Japan in the Elementary School.

    Science.gov (United States)

    Cogan, John J.

    1981-01-01

    Focuses on ideas for teaching about Japan which elementary school classroom teachers can use to supplement a textbook unit on Japan. Suggestions are intended to allow for reflection by students on their own culture, as well as the culture of Japan. Topics are children's perceptions of Japan and the Japanese, developing a geographical perspective,…

  20. 2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition).

    Science.gov (United States)

    Satoh, Tetsurou; Isozaki, Osamu; Suzuki, Atsushi; Wakino, Shu; Iburi, Tadao; Tsuboi, Kumiko; Kanamoto, Naotetsu; Otani, Hajime; Furukawa, Yasushi; Teramukai, Satoshi; Akamizu, Takashi

    2016-12-30

    Thyroid storm is an endocrine emergency which is characterized by multiple organ failure due to severe thyrotoxicosis, often associated with triggering illnesses. Early suspicion, prompt diagnosis and intensive treatment will improve survival in thyroid storm patients. Because of its rarity and high mortality, prospective intervention studies for the treatment of thyroid storm are difficult to carry out. We, the Japan Thyroid Association and Japan Endocrine Society taskforce committee, previously developed new diagnostic criteria and conducted nationwide surveys for thyroid storm in Japan. Detailed analyses of clinical data from 356 patients revealed that the mortality in Japan was still high (∼11%) and that multiple organ failure and acute heart failure were common causes of death. In addition, multimodal treatment with antithyroid drugs, inorganic iodide, corticosteroids and beta-adrenergic antagonists has been suggested to improve mortality of these patients. Based on the evidence obtained by nationwide surveys and additional literature searches, we herein established clinical guidelines for the management of thyroid storm. The present guideline includes 15 recommendations for the treatment of thyrotoxicosis and organ failure in the central nervous system, cardiovascular system, and hepato-gastrointestinal tract, admission criteria for the intensive care unit, and prognostic evaluation. We also proposed preventive approaches to thyroid storm, roles of definitive therapy, and future prospective trial plans for the treatment of thyroid storm. We hope that this guideline will be useful for many physicians all over the world as well as in Japan in the management of thyroid storm and the improvement of its outcome.

  1. Current status of fiber optic gyro efforts for space applications in Japan

    Science.gov (United States)

    Mitani, Shinji; Mizutani, Tadahito; Sakai, Shin-ichiro

    2016-05-01

    In response to the maturation of Fiber Optic Gyro technologies, FOGs are being used in various applications. Also in Japan, the demand for FOG is high, and is used in some space applications. In this paper, we introduce examples of Japanese products that apply to space-use. It also describes some efforts for high-grade navigation use in Japan.

  2. Brain/MINDS: brain-mapping project in Japan

    Science.gov (United States)

    Okano, Hideyuki; Miyawaki, Atsushi; Kasai, Kiyoto

    2015-01-01

    There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas. PMID:25823872

  3. Modulation of Neuroimmune Responses on Glia in the Central Nervous System: Implication in Therapeutic Intervention against Neuroinflammation

    Institute of Scientific and Technical Information of China (English)

    Raymond Chuen-Chung Chang; Kin Chiu; Yuen-Shan Ho; Kwok-Fai So

    2009-01-01

    It has long been known that the brain is an immunologically privileged site in normal conditions. Although the cascade of immune responses can occur as long as there is a neuronal injury or a potent immune stimulation, how the brain keeps gliai cells in a quiescent state is still unclear. Increasing efforts have been made by several laboratories to elucidate how repression of immune responses is achieved in the neuronal environment. The suppression factors include neurotransmitters, neurohormones, neurotrophic factors, anti-inflammatory factors, and cell-cell contact via adhesion molecules or CD200 receptor. This review discusses how these factors affect the cascade of cerebral immune responses because no single factor listed above can fully account for the immune suppression. While several factors contribute to the suppression of immune responses, activation of glial cells and their production of pro-inflammatory factors do occur as long as there is a neuronal injury, suggesting that some neuronal components facilitate immune responses. This review also discusses which signals initiate or augment cerebral immune responses so that stimulatory signals override the suppressive signals. Increasing lines of evidence have demonstrated that immune responses in the brain are not always detrimental to neurons. Attempt to simply clear off inflammatory factors in the CNS may not be appropriate for neurons in neurological disorders. Appropriate control of immune cells in the CNS may be beneficial to neurons or even neuroregeneration. Therefore, understanding the mechanisms underlying immune suppression may help us to reshape pharmacological interventions against inflammation in many neurological disorders. Cellular & Molecular Immunology. 2009;6(5): 317-326.

  4. Positioning Indian Emigration to Japan

    DEFF Research Database (Denmark)

    D'Costa, Anthony

    2013-01-01

    as other IT-strong developing countries, are to supply technical talent, whose availability in Japan is constrained by the secular demographic crisis and changing educational and occupational preferences. The challenges for India are the institutional barriers, in particular, Japanese business practices...... that act as significant barriers to the entry of foreign skilled professionals. The paper brings out the source and pattern of foreign professionals and students in Japan as a proxy for talent. Though India’s presence in Japan is currently limited, its share of technical professionals to the total number...... of Indians in Japan is the highest. Also, the preconditions in the Japanese economy suggest a historic opportunity to forge a long-term, mutually beneficial, bilateral partnership between the two countries. For India, this means reducing its dependence on the US market and availing new learning opportunities...

  5. 1983 Akita, Honshu, Japan Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The tsunami generated by a magnitude 7.9 (Mw) earthquake destroyed 700 boats and 59 houses for a total of $800 million in property damage in Japan (1983 dollars)....

  6. Helicobacter pylori infection in Japan

    Science.gov (United States)

    Shiota, Seiji; Murakawi, Kazunari; Suzuki, Rumiko; Fujioka, Toshio; Yamaoka, Yoshio

    2013-01-01

    The prevalence of Helicobacter pylori infection is gradually decreasing in Japan. On the main island of Japan, nearly all H. pylori isolates possess cagA and vacA with strong virulence. However, less virulent H. pylori strains are frequently found in Okinawa where cases of gastric cancer are the lowest in Japan. Eradication therapy for peptic ulcer, idiopathic thrombocytopenic purpura, gastric mucosa-associated lymphoid tissue lymphoma and early gastric cancer after endoscopic resection has been approved by the Japanese national health insurance system. However, the Japanese Society for Helicobacter Research recently stated that all ‘H. pylori infection’ was considered as the indication for eradication irrespective of the background diseases. To eliminate H. pylori in Japan, the Japanese health insurance system should approve the eradication of all H. pylori infections. PMID:23265147

  7. The Social Sciences in Japan

    Science.gov (United States)

    Watanuki, Joji

    1975-01-01

    This article relates a brief historical background of social sciences in Japan, the institutional framework of social science education and research, and major issues and perspectives for the development of the social scinces. (ND)

  8. Investigating the dynamics of the brain response to music: A central role of the ventral striatum/nucleus accumbens.

    Science.gov (United States)

    Mueller, Karsten; Fritz, Thomas; Mildner, Toralf; Richter, Maxi; Schulze, Katrin; Lepsien, Jöran; Schroeter, Matthias L; Möller, Harald E

    2015-08-01

    Ventral striatal activity has been previously shown to correspond well to reward value mediated by music. Here, we investigate the dynamic brain response to music and manipulated counterparts using functional magnetic resonance imaging (fMRI). Counterparts of musical excerpts were produced by either manipulating the consonance/dissonance of the musical fragments or playing them backwards (or both). Results show a greater involvement of the ventral striatum/nucleus accumbens both when contrasting listening to music that is perceived as pleasant and listening to a manipulated version perceived as unpleasant (backward dissonant), as well as in a parametric analysis for increasing pleasantness. Notably, both analyses yielded a ventral striatal response that was strongest during an early phase of stimulus presentation. A hippocampal response to the musical stimuli was also observed, and was largely mediated by processing differences between listening to forward and backward music. This hippocampal involvement was again strongest during the early response to the music. Auditory cortex activity was more strongly evoked by the original (pleasant) music compared to its manipulated counterparts, but did not display a similar decline of activation over time as subcortical activity. These findings rather suggest that the ventral striatal/nucleus accumbens response during music listening is strongest in the first seconds and then declines.

  9. Diatom assemblage responses to changing environment in the conspicuously eutrophic Kiuruvesi lake route, central-eastern Finland

    Science.gov (United States)

    Tammelin, Mira; Kauppila, Tommi

    2016-04-01

    Lakes and their water quality have been affected by anthropogenic actions for centuries. The most intensive changes have often occurred since the mid-19th century. Industrialization, modern agriculture, forest ditching and artificial lowering of water level are examples of these changes that have usually resulted in the deterioration of lake water quality. Many organisms, such as diatoms, are sensitive to these changes in their environmental conditions. Therefore, a marked species turnover is often seen between the pre and post human impact diatom assemblages. This turnover can be rapidly assessed simultaneously from many lakes by using multivariate methods and top-bottom sampling. Our study area consists of three adjacent lake routes in the grass cultivation and dairy production area of central-eastern Finland, where slash-and-burn cultivation and artificial water level lowering were common practice during the past centuries. The centermost Iisalmi lake route is particularly interesting because of the conspicuously eutrophic lakes in its Kiuruvesi subroute. We used the top-bottom approach to sample pre and post human impact samples from 47 lakes (50 sampling sites) located in the three lake routes. In addition, stratigraphic samples from the long cores of three lakes (one larger central basin and two small upstream lakes) in the Kiuruvesi subroute were studied in more detail. Multivariate methods were used to assess diatom assemblage change within the long cores and between the pre-disturbance and modern samples. The results indicate that most study lakes have undergone a marked shift in their diatom assemblages since the onset of human impact in the area. The lake routes are characterized by differing pre-impact diatom assemblages. However, human influence has reduced their natural variation. Similar diatom species are common in the modern samples of the heavily impacted lakes in all three lake routes. The detailed examination of the diatom assemblage turnover in

  10. Central mechanism of the cardiovascular responses caused by L-proline microinjected into the paraventricular nucleus of the hypothalamus in unanesthetized rats.

    Science.gov (United States)

    Lopes-Azevedo, Silvana; Busnardo, Cristiane; Corrêa, Fernando Morgan Aguiar

    2016-12-01

    Previously, we reported that microinjection of L-proline (L-Pro) into the paraventricular nucleus of the hypothalamus (PVN) caused vasopressin-mediated pressor responses in unanesthetized rats. In the present study, we report on the central mechanisms involved in the mediation of the cardiovascular effects caused by the microinjection of L-Pro into the PVN. Microinjection of increasing doses of L-Pro (3-100nmol/100nL) into the PVN caused dose-related pressor and bradycardic responses. No cardiovascular responses were observed after the microinjection of equimolar doses (33nmol/100nL) of its isomer D-Proline (D-Pro) or Mannitol. The PVN pretreatment with either a selective non-NMDA (NBQX) or selective NMDA (LY235959 or DL-AP7) glutamate receptor antagonists blocked the cardiovascular response to L-Pro (33nmol/100nL). The dose-effect curve for the pretreatment with increasing doses of LY235959 was located at the left in relation to the curves for NBQX and DL-AP7, showing that LY235959 is more potent than NBQX, which is more potent than DL-AP7 in inhibiting the cardiovascular response to L-Pro. The cardiovascular response to the microinjection of L-Pro into the PVN was not affected by local pretreatment with N(ω)-Propyl-l-arginine (N-Propyl), a selective inhibitor of the neuronal nitric oxide synthase (nNOS), suggesting that NO does not mediate the responses to L-Pro in the PVN. In conclusion, the results suggest that ionotropic receptors in the PVN, blocked by both NMDA and non-NMDA receptor antagonists, mediate the pressor response to L-Pro that results from activation of PVN vasopressinergic magnocellular neurons and vasopressin release into the systemic circulation.

  11. WILL FERTILITY REBOUND IN JAPAN

    OpenAIRE

    Creina Day

    2012-01-01

    Fertility and per capita income are now positively associated across most high income OECD countries. Low fertility and a gender wage gap persist in Japan. This paper presents an original model where endogenous increases in childcare prices and gender equity in capital allocation play important roles in the effect of per capita income growth and rising female relative wages on fertility. Results suggest Japan has cause for optimism. Economic growth will raise female relative wages where capit...

  12. Japan Sports Arbitration Agency (JSAA

    Directory of Open Access Journals (Sweden)

    Ekaterina P. Rusakova

    2015-12-01

    Full Text Available In this article author analyzes the activities of Japan Sports Arbitration Agency. Author considers the goals, objectives and procedure for dealing with disputes relating to the use of performance-enhancing drugs by athletes. Author study the regulation of Japan Sports Arbitration Agency, to resolve disputes relating to the use of doping, as well as the procedure for application and acceptance of its agency, the choice of arbitrators, counterclaim, protection of evidence.

  13. Japan Report, Science and Technology.

    Science.gov (United States)

    2007-11-02

    include water temperature, water quality, ocean currents, sea ice, wave conditions, coastal conditions, and marine resources. Environmental polution ... air , and food supplies (procured in Japan) to the station for use by its crew. It is also a real possibility that Japan’s data relay satellite (DRTS...the pressurized unit via a mechanical manipulator and an air lock to permit the exchange of equipment and samples and the assembly of space

  14. Autoimmune central diabetes insipidus in a patient with ureaplasma urealyticum infection and review on new triggers of immune response.

    Science.gov (United States)

    Murdaca, Giuseppe; Russo, Rodolfo; Spanò, Francesca; Ferone, Diego; Albertelli, Manuela; Schenone, Angelo; Contatore, Miriam; Guastalla, Andrea; De Bellis, Annamaria; Garibotto, Giacomo; Puppo, Francesco

    2015-12-01

    Diabetes insipidus is a disease in which large volumes of dilute urine (polyuria) are excreted due to vasopressin (AVP) deficiency [central diabetes insipidus (CDI)] or to AVP resistance (nephrogenic diabetes insipidus). In the majority of patients, the occurrence of CDI is related to the destruction or degeneration of neurons of the hypothalamic supraoptic and paraventricular nuclei. The most common and well recognized causes include local inflammatory or autoimmune diseases, vascular disorders, Langerhans cell histiocytosis (LCH), sarcoidosis, tumors such as germinoma/craniopharyngioma or metastases, traumatic brain injuries, intracranial surgery, and midline cerebral and cranial malformations. Here we have the opportunity to describe an unusual case of female patient who developed autoimmune CDI following ureaplasma urealyticum infection and to review the literature on this uncommon feature. Moreover, we also discussed the potential mechanisms by which ureaplasma urealyticum might favor the development of autoimmune CDI.

  15. A Cell Line Producing Recombinant Nerve Growth Factor Evokes Growth Responses in Intrinsic and Grafted Central Cholinergic Neurons

    Science.gov (United States)

    Ernfors, Patrik; Ebendal, Ted; Olson, Lars; Mouton, Peter; Stromberg, Ingrid; Persson, Hakan

    1989-06-01

    The rat β nerve growth factor (NGF) gene was inserted into a mammalian expression vector and cotransfected with a plasmid conferring resistance to neomycin into mouse 3T3 fibroblasts. From this transfection a stable cell line was selected that contains several hundred copies of the rat NGF gene and produces excess levels of recombinant NGF. Such genetically modified cells were implanted into the rat brain as a probe for in vivo effects of NGF on central nervous system neurons. In a model of the cortical cholinergic deficits in Alzheimer disease, we demonstrate a marked increase in the survival of, and fiber outgrowth from, grafts of fetal basal forebrain cholinergic neurons, as well as stimulation of fiber formation by intact adult intrinsic cholinergic circuits in the cerebral cortex. Adult cholinergic interneurons in intact striatum also sprout vigorously toward implanted fibroblasts. Our results suggest that this model has implications for future treatment of neurodegenerative diseases.

  16. 根据日本中部琵琶湖深井孢粉资料重建第四纪古植被和古气候及全球古气候对比%PALAEOVEGETATION AND PALAEOCLIMATE DURING THE QUATERNARY PERIOD BASED ON THE LONG CORES FROM LAKE BIWA, CENTRAL JAPAN, AND GLOBAL CORRELATION OF THE PALAEOCLIMATE RECORDS

    Institute of Scientific and Technical Information of China (English)

    藤则雄

    2003-01-01

    根据日本中部琵琶湖深井钻探资料研究了过去3Ma的古植被、地层及古气候.由湖底取得的200m和1 400m样品的孢粉组合可分别划分出19个和37个带,反映了湖区及其周围自晚上新世以来的古植被和古气候演变史.在冰期阶时琵琶湖附近山区的典型植被为亚北极带,低地为冷温带.而在间冰期阶里山区一般为温带或冷温带植被,低地则主要由落叶和常绿树组成的温带和暖温带的植被.在进行过去3Ma古植被、古气候演变对比中,当地古气候史和以下资料显示出明显的一致,例如加勒比海、西太平洋及赤道海洋的氧同位素资料,地中海西部(Mallorca)的沉积旋回,欧洲中部的风成沉积序列,日本关东和新几内亚的海平面变化记录,以及在南美波哥大高地和以色列死海裂谷根据孢粉得出的古气候变化记录.%Investigation was carried out on the palaeovegetation, stratigraphy and palaeoclimate in the last 3 Ma based onthe long cores from the Lake Biwa, Central Japan. Samples of 200-meter and 1400-meter cores obtained from the bottom of thelake yield nineteen and thirty-seven pollen zones respectively showing the palaeovegetational and palaeoclimatic changes inand around the lake since the late Pliocene period. During the glacial stages or stadials, typical vegetation of the subpolar zoneoccurred in the mountainous area around Lake Biwa. While in the lowland area in and around the lake, characteristic plants ofthe Cool Temperate zone occurred. During the interglacial stages or interstadials the vegetation of the mountainous area wasgenerally characterized by plants of the Temperate zone and/or Cool Temperate zone, while in the lowland area the vegetationwas composed mainly of deciduous and evergreen broad-leaved trees of the Temperate and Warm Temperate zones. In theglobal correlation from the viewpoints of palaeovegetation and palaeoclimate changes during the last 3 Ma since the late

  17. Tree-rings mirror management legacy: dramatic response of standard oaks to past coppicing in Central Europe.

    Directory of Open Access Journals (Sweden)

    Jan Altman

    Full Text Available BACKGROUND: Coppicing was one of the most important forest management systems in Europe documented in prehistory as well as in the Middle Ages. However, coppicing was gradually abandoned by the mid-20(th century, which has altered the ecosystem structure, diversity and function of coppice woods. METHODOLOGY/PRINCIPAL FINDINGS: Our aim was to disentangle factors shaping the historical growth dynamics of oak standards (i.e. mature trees growing through several coppice cycles in a former coppice-with-standards in Central Europe. Specifically, we tried to detect historical coppicing events from tree-rings of oak standards, to link coppicing events with the recruitment of mature oaks, and to determine the effects of neighbouring trees on the stem increment of oak standards. Large peaks in radial growth found for the periods 1895-1899 and 1935-1939 matched with historical records of coppice harvests. After coppicing, the number of newly recruited oak standards markedly grew in comparison with the preceding or following periods. The last significant recruitment of oak standards was after the 1930s following the last regular coppicing event. The diameter increment of oak standards from 1953 to 2003 was negatively correlated with competition indices, suggesting that neighbouring trees (mainly resprouting coppiced Tilia platyphyllos partly suppressed the growth of oak standards. Our results showed that improved light conditions following historical coppicing events caused significant increase in pulses of radial growth and most probably maintained oak recruitment. CONCLUSIONS/SIGNIFICANCE: Our historical perspective carries important implications for oak management in Central Europe and elsewhere. Relatively intense cutting creating open canopy woodlands, either as in the coppicing system or in the form of selective cutting, is needed to achieve significant radial growth in mature oaks. It is also critical for the successful regeneration and long

  18. Seismic moment of the 1891 Nobi, Japan, earthquake estimated from historical seismograms

    Science.gov (United States)

    Fukuyama, E.; Muramatu, I.; Mikumo, T.

    2007-06-01

    The seismic moment of the 1891 Nobi, Japan, earthquake has been evaluated from the historical seismogram recorded at the Central Meteorological Observatory in Tokyo. For this purpose, synthetic seismograms from point and finite source models with various fault parameters have been calculated by a discrete wave-number method, incorporating the instrumental response of the Gray-Milne-Ewing seismograph, and then compared with the original records. Our estimate of the seismic moment (Mo) is 1.8 × 1020 N m corresponding to a moment magnitude (Mw) 7.5. This is significantly smaller than the previous estimates from the distribution of damage, but is consistent with that inferred from geological field survey (Matsuda, 1974) of the surface faults.

  19. Response of middle-taiga permafrost landscapes of Central Siberia to global warming in the late 20th and early 21st centuries

    Science.gov (United States)

    Medvedkov, Alexey A.

    2016-11-01

    In this paper, regional features of a climatogenic response of the middle-taiga permafrost landscapes of Central Siberia, as well as corresponding transformations of the exodynamic processes, are considered. Lithological-geomorphologic and landscape- geocryological data are analyzed with large amounts of actual data and results of monitoring surveys. Specific features of an ecotone localization of middle-taiga permafrost landscapes and their typical physiognomic characteristics are described. A comprehensive investigation of representative key sites makes it possible to discover the response of different types of permafrost landscapes to regional climate warming. A rapid increase in the active layer depth, slower creep, transformations of the moving kurums, intensive solifluction, and a local replacement of solifluction by landslides-earthflows are revealed within ecotone landscapes of the cryolithozone.

  20. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report.

    Science.gov (United States)

    Wang, Xiaolin; Huang, Dehui; Huang, Xusheng; Zhang, Jiatang; Ran, Ye; Lou, Xin; Gui, Qiuping; Yu, Shengyuan

    2017-04-15

    Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroid (CLIPPERS) was first described in 2010. The characteristic clinical picture, radiological distribution and steroid response have been well-described in previous reports. However, the underlying pathogenesis and nosological position of CLIPPERS in the CNS require further investigation for the primary CNS lymphoma have been identified by autopsy subsequently. Here, we report a 51-year-old woman who was diagnosed with CLIPPERS but progressed to primary CNS lymphomatoid granulomatosis, which supports that CLIPPERS is not just an inflammatory CNS disorder.