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Sample records for central hidroelectrica ing

  1. Electric generator overhaul of the Ing. Carlos Ramirez Ulloa hydroelectric. Central project conclusions; Rehabilitacion de los generadores de la central hidroelectrica Ing. Carlos Ramirez Ulloa. Conclusiones del proyecto

    Energy Technology Data Exchange (ETDEWEB)

    Campuzano Martinez, Ignacio Roberto; Gonzalez Vazquez, Alejandro Esteban; Robles Pimentel, Edgar Guillermo; Esparza Saucedo, Marcos; Garcia Martinez, Javier; Sanchez Flores, Ernesto; Martinez Romero, Jose Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-12-31

    The Hydroelectric Ing. Carlos Ramirez Ulloa Power Central has three 200 MW electric generators. The Central initiated its commercial operation in 1985. The electric generators had design problems that were properly corrected in an overhaul program that was initiated in 1996, with Unit 2 electric generator and completed in 1998 with Unit 1 electric generator. This paper presents the relevant aspects of the experience accumulated in the project. [Espanol] La central hidroelectrica Ing. Carlos Ramirez Ulloa cuenta con tres generadores de 200 MW cada uno. La central inicio su operacion comercial en 1985. Los generadores tenian problemas de diseno que fueron debidamente corregidos en un programa de rehabilitacion que inicio en 1996, con el generador de la unidad 2, y culmino en 1998 con el generador de la unidad 1. En este articulo se presentan los aspectos relevantes de la experiencia acumulada en el proyecto.

  2. Overhaul of the generator of the hydroelectric central station Ingeniero Carlos Ramirez Ulloa; Rehabilitacion del generador de la unidad 2 de la central hidroelectrica ingeniero Carlos Ramirez Ulloa

    Energy Technology Data Exchange (ETDEWEB)

    Robles Pimentel, Edgar [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Garcia Hernandez, Javier [Comision Federal de Electricidad, Mexico, D. F. (Mexico)

    1997-12-31

    In November 1995, the failure of the Unit 2 generator at the hydroelectric central station Ingeniero Carlos Ramirez Ulloa, El Caracol, occurred. The accident forced to carry out its overhaul. Here are presented the technical problems faced during the overhaul of the generator and analyzed the implemented solutions. [Espanol] En noviembre de 1995 ocurrio la falla del generador de la unidad 2 de la central hidroelectrica Ing. Carlos Ramirez Ulloa, El Caracol. El accidente obligo a llevar a cabo su rehabilitacion. Se presentan los problemas tecnicos enfrentados durante la rehabilitacion del generador y se discuten las soluciones implementadas.

  3. Methodology for maintenance analysis based on hydroelectric power stations reliability; Metodologia para realizar analisis de mantenimiento basado en confiabilidad en centrales hidroelectricas

    Energy Technology Data Exchange (ETDEWEB)

    Rea Soto, Rogelio; Calixto Rodriguez, Roberto; Sandoval Valenzuela, Salvador; Velasco Flores, Rocio; Garcia Lizarraga, Maria del Carmen [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2012-07-01

    A methodology to carry out Reliability Centered Maintenance (RCM) studies for hydroelectric power plants is presented. The methodology is an implantation/extension of the guidelines proposed by the Engineering Society for Advanced Mobility Land, Sea and Space in the SAE-JA1012 standard. With the purpose of answering the first five questions, that are set out in that standard, the use of standard ISO14224 is strongly recommended. This approach standardizes failure mechanisms and homogenizes RCM studies with the process of collecting failure and maintenance data. The use of risk matrixes to rank the importance of each failure based on a risk criteria is also proposed. [Spanish] Se presenta una metodologia para realizar estudios de mantenimiento Basado en Confiabilidad (RCM) aplicados a la industria hidroelectrica. La metodologia es una implantacion/ extension realizada por los autores de este trabajo, de los lineamientos propuestos por la Engineering Society for Advanced Mobility Land, Sea and Space en el estandar SAE-JA1012. Para contestar las primeras cinco preguntas del estandar se propone tomar como base los modos y mecanismos de fallas de componentes documentados en la guia para recopilar datos de falla en el estandar ISO-14224. Este enfoque permite estandarizar la descripcion de mecanismos de fallas de los equipos, tanto en el estudio RCM como en el proceso de recopilacion de datos de falla y de mantenimiento, lo que permite retroalimentar el ciclo de mejora continua de los procesos RCM. Tambien se propone el uso de matrices de riesgo para jerarquizar la importancia de los mecanismos de falla con base en el nivel de riesgo.

  4. Reliability of hydroelectric generation components, systems and units; Confiabilidad de componentes, sistemas y unidades de generacion hidroelectrica

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Sanchez, Ramon; Torres Toledano, Gerardo; Franco Nava, Jose Manuel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1996-12-31

    This article presents a methodology for the calculation of the reliability of components, systems and hydroelectric generating units, as well as the scope of a computational system for the evaluation of such reliability. In the case of the reliability calculation of components and systems, the computer programs is not limited to hydro stations and can be used in other type of systems. [Espanol] En este articulo se presenta una metodologia para calcular la confiabilidad de componentes, sistemas y unidades de generacion hidroelectrica, asi como el alcance de un sistema computacional para evaluar dicha confiabilidad. En el caso del calculo de confiabilidad de componentes y sistemas, el programa de computo no se limita a centrales hidroelectricas y puede utilizarse en otro tipo de sistemas.

  5. Electro-economic, environmental and social consequences in the efficient abatement of a hydroelectric plant (C. H. Santa Rosa, CFE-ACO); Consecuencias electro-economicas, ambientales y sociales del abatimiento eficiente de una central hidroelectrica (C. H. Santa Rosa, CFE-ACO)

    Energy Technology Data Exchange (ETDEWEB)

    Narvaez Perez, Camilo; Garcia Conejo, Dante Aristoteles [Comision Federal de Electricidad, Centro Nacional de Control de Energia, Area de Control Occidental, Zapopan, Jalisco (Mexico)]. E-mail: camilo.narvaez@cfe.gob.mx; camilo.narvaez@univa.mx; Narvaez Perez, Claudia Universidad de Guadalajara, Zapopan, Jalisco [Mexico]). E-mail: claudia_narvaez@hotmail.com; Blanco Gomez, Cesar Eduardo [Comision Federal de Electricidad, Centro Nacional de Control de Energia, Area de Control Occidental, Zapopan, Jalisco (Mexico)

    2013-03-15

    Renewable energy systems, like hydroelectric generation system gives electric energy, in reliable economic, it takes care with environment, and growths the society, if the hydroelectric dam is suitably drained in non rainy season, if we consider, flow rate in its river, rain, thunderstorms and floods, dam's size, load shape per day, generators capacity unit and the flow in turbines, generating units maintenance and other necessities like irrigation crops in farms. In this research we propose a new methodology about hydroelectric dam drained in non rainy season. But in rainy season, you can consider this methodology with few changes and you would obtain satisfactory results. The methodology is used since 2010 in the Area de Control Occidental in the Comision Federal de Electricidad with results compared with data from previous years, in which different methodologies were applied. [Spanish] Los sistemas de energias renovables, como los complejos hidroelectricos impactan de manera electrica, economica, ambiental y social, siempre y cuando se realice adecuadamente el abatimiento de la presa en el estiaje, considerando, el aporte del cauce, las lluvias aun siendo escasas, el tamano del embalse, la demanda horaria de la carga abastecida, el tamano de los generadores y su gasto turbinado, los mantenimientos de las unidades, las necesidades hidraulicas aguas abajo y demas imponderantes. En esta investigacion se propone una metodologia de abatimiento de presas de centrales hidroelectricas en estiaje. Y para tiempo de lluvias se aplica la metodologia con variantes pequenas y con resultados satisfactorios. La metodologia es utilizada desde el 2010 en el Area de Control Occidental de la Comision Federal de Electricidad, con resultados comparados con los datos de los anos anteriores, en los cuales se aplicaron metodologias diversas.

  6. "GAG-ing with the neuron": The role of glycosaminoglycan patterning in the central nervous system.

    Science.gov (United States)

    Smith, Patrice D; Coulson-Thomas, Vivien J; Foscarin, Simona; Kwok, Jessica C F; Fawcett, James W

    2015-12-01

    Proteoglycans (PGs) are a diverse family of proteins that consist of one or more glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major components of the extracellular matrix (ECM) and play critical roles in development, normal function and damage-response of the central nervous system (CNS). GAGs are classified based on their disaccharide subunits, into the following major groups: chondroitin sulfate (CS), heparan sulfate (HS), heparin (HEP), dermatan sulfate (DS), keratan sulfate (KS) and hyaluronic acid (HA). All except HA are modified by sulfation, giving GAG chains specific charged structures and binding properties. While significant neuroscience research has focused on the role of one PG family member, chondroitin sulfate proteoglycan (CSPG), there is ample evidence in support of a role for the other PGs in regulating CNS function in normal and pathological conditions. This review discusses the role of all the identified PG family members (CS, HS, HEP, DS, KS and HA) in normal CNS function and in the context of pathology. Understanding the pleiotropic roles of these molecules in the CNS may open the door to novel therapeutic strategies for a number of neurological conditions. PMID:26277685

  7. Hydroelectric microcentrals for small consumption centers; Microcentrales hidroelectricas para pequenos centros de consumo

    Energy Technology Data Exchange (ETDEWEB)

    Angeles A, V. H.; Espino C, F. P. [Universidad Autonoma Metropolitana, Mexico, D. F. (Mexico); Buitron Sanchez, H. C. [Programa de Ahorro de Energia para el Sector Electrico, Mexico, D. F. (Mexico)

    1995-12-31

    The utilization of alternate energy sources (wind power, solar and hydro to small scale) represents an option for the rural electrification. This paper analyzes the case of hydro microgeneration, for this purpose the mechanical and electrical fitting are mainly discussed. For the mechanical re-equipment the turbine types that can be used are fundamentally presented and how they can be selected. As to the electrical re-equipment the different types of electric generators are discussed, as well as the form of selecting them, the operation, the control and the protection in the hydroelectric microcentrals. [Espanol] La utilizacion de fuentes alternas de energia (eolica, solar e hidraulica a pequena escala) representan una alternativa para la electrificacion rural. Este trabajo trata del caso de la microgeneracion hidraulica para la cual se discuten principalmente, alternativas para el equipamiento mecanico y electrico. Para el equipamiento mecanico se presentan fundamentalmente los tipos de turbinas que pueden ser utilizadas y como se pueden seleccionar. En cuanto al equipo electrico se manejan los diferentes tipos de generadores, la forma de seleccionarlos, la operacion, el control y la proteccion en las microcentrales hidroelectricas.

  8. Engineering challenges in ING

    International Nuclear Information System (INIS)

    With the Intense Neutron Generator (ING) we intend to produce a neutron flux of 1016 n/cm2 sec. Bismuth, bombarded by 1 GeV protons, yields about 20 neutrons per proton with a heat output of 23 MeV/neutron. A circulating liquid bismuth target will dissipate about 34 MW of heat. To produce the beam we will accelerate protons in a separated orbit cyclotron. The 65 mA current will require about 70-75 MW of radio-frequency power (50-200 Mc/s). We must generate and transmit RF efficiently. In ING precise magnet-fields, resonating-cavity electric-fields and well maintained vacuum (10-6 torr) will place demands on most of today's engineering technology. (author)

  9. RegulatING chromatin regulators

    DEFF Research Database (Denmark)

    Satpathy, Shankha; Nabbi, Arash; Riabowol, Karl

    2013-01-01

    The five human ING genes encode at least 15 splicing isoforms, most of which affect cell growth, differentiation and apoptosis through their ability to alter gene expression by epigenetic mechanisms. Since their discovery in 1996, ING proteins have been classified as type II tumour suppressors on...... the basis of reports describing their down-regulation and mislocalization in a variety of cancer types. In addition to their regulation by transcriptional mechanisms, understanding the range of PTMs (post-translational modifications) of INGs is important in understanding how ING functions are fine...... stresses. We also describe the ING PTMs that have been identified by several unbiased MS-based PTM enrichment techniques and subsequent proteomic analysis. Among the ING PTMs identified to date, a subset has been characterized for their biological significance and have been shown to affect processes...

  10. Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis

    International Nuclear Information System (INIS)

    The INhibitor of Growth (ING) family of plant homeodomain (PHD) proteins induce apoptosis and regulate gene expression through stress-inducible binding of phospholipids with subsequent nuclear and nucleolar localization. Relocalization occurs concomitantly with interaction with a subset of nuclear proteins, including PCNA, p53 and several regulators of acetylation such as the p300/CBP and PCAF histone acetyltransferases (HATs), as well as the histone deacetylases HDAC1 and hSir2. These interactions alter the localized state of chromatin compaction, subsequently affecting the expression of subsets of genes, including those associated with the stress response (Hsp70), apoptosis (Bax, MDM2) and cell cycle regulation (p21WAF1, cyclin B) in a cell- and tissue-specific manner. The expression levels and subcellular localization of ING proteins are altered in a significant number of human cancer types, while the expression of ING isoforms changes during cellular aging, suggesting that ING proteins may play a role in linking cellular transformation and replicative senescence. The variety of functions attributed to ING proteins suggest that this tumor suppressor serves to link the disparate processes of cell cycle regulation, cell suicide and cellular aging through epigenetic regulation of gene expression. This review examines recent findings in the ING field with a focus on the functions of protein-protein interactions involving ING family members and the mechanisms by which these interactions facilitate the various roles that ING proteins play in tumorigenesis, apoptosis and senescence

  11. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  12. Des ingénieurs perdus

    OpenAIRE

    Desbois, Evelyne

    2014-01-01

    Dans cet essai de reconstitution d’une période de l’histoire politique et sociale du bassin minier, la figure de l’ingénieur traversait les récits recueillis auprès des mineurs, mais de manière le plus souvent anecdotique. En revanche, elle occupait une place beaucoup plus importante et souvent centrale dans les discours politiques et les revendications syndicales de cette époque. Cette émergence inattendue et brutale sur la scène publique d’une catégorie socio-professionnelle surprend d’auta...

  13. ING status report July 1967

    International Nuclear Information System (INIS)

    Evolution of ING from initial concept to advanced systems and the interplay between participating disciplines are illustrated in Fig. 1.2. Anticipated requirements for intense continuous fluxes of thermal neutrons set the initial goal and dictated the scale and other guidelines of the system including the desired completion date. While neutron applications were given prime consideration in conceptual planning, much wider fields of research, both pure and applied, would benefit from the facility now being studied. (author)

  14. ING status report July 1967

    Energy Technology Data Exchange (ETDEWEB)

    Church, T.G

    1967-07-01

    Evolution of ING from initial concept to advanced systems and the interplay between participating disciplines are illustrated in Fig. 1.2. Anticipated requirements for intense continuous fluxes of thermal neutrons set the initial goal and dictated the scale and other guidelines of the system including the desired completion date. While neutron applications were given prime consideration in conceptual planning, much wider fields of research, both pure and applied, would benefit from the facility now being studied. (author)

  15. 75 FR 16456 - Inglis Hydropower, LLC; Notice Soliciting Scoping Comments

    Science.gov (United States)

    2010-04-01

    ... Energy Regulatory Commission Inglis Hydropower, LLC; Notice Soliciting Scoping Comments March 26, 2010.... c. Date filed: July 22, 2009. d. Applicant: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The proposed project would be located at the existing Inglis Bypass...

  16. ING1 induces apoptosis through direct effects at the mitochondria

    DEFF Research Database (Denmark)

    Bose, P; Thakur, S; Thalappilly, S;

    2013-01-01

    translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. The ability of ING1 to induce apoptosis in various breast cancer cell lines correlates well with its degree of translocation to the...... mitochondria after UV treatment. Endogenous ING1 protein specifically interacts with the pro-apoptotic BCL2 family member BAX, and colocalizes with BAX in a UV-inducible manner. Ectopic expression of a mitochondria-targeted ING1 construct is more proficient in inducing apoptosis than the wild type ING1 protein...

  17. ING: a vehicle to new frontiers

    International Nuclear Information System (INIS)

    The Intense Neutron Generator (ING) is primarily an original design for an advanced research instrument for the production of sub-atomic particles, especially neutrons and mesons. But, actually, it is far more than that: It is expected to be the heart of a many-sided research institute, and at the same time a production facility making both direct and indirect contributions to Canadian trade. The major advances in technology in the world have taken place under the spur of an inspiring and intensely competitive situation. Examples are radar, the jet aircraft and the atomic bomb in World War II, and in more recent times, Sputnik and the race to the moon. These objectives also have funded the major technical developments of transistors and electronic computers and, to some extent, economic nuclear power. (author)

  18. The allocation of hydroelectric units in the short term planning of the operation of electrical power systems; La asignacion de unidades hidroelectricas en la planeacion de corto plazo de la operacion de los sistemas electricos de potencia

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Casillas, Manuel Eduardo

    1986-05-01

    A method is presented to find an approximated solution to the allocation problem of hydroelectric units. The problem consists in determining, for each one of the intervals the planned period, which hydroelectric units will be in operation and how much they will generate, so that the production cost of thermoelectric energy is minimum. The solution must satisfy certain operation policies, and restrictions of physical origin and safety. The modeling of the system elements is very detailed, for example, are considered: the not-linear dependency of the generating units with respect to the cost and the net height, the effects of the discharge level and the losses in conducts, and the relation volume storage against level in the dams. Mathematically, the problem is of non-linear programming, with continuous and discreet variables; in addition, if it is of large scale: in a real case, as de one that appears here, the problem has 16600 continuous variables, 8400 binary variables, and 51000 restrictions. The method exploits the problem structure and the modeled elements characteristics. It obtains a solution in reasonable computing time, and provides a lower elevation to the value of the optimal solution, which allows to judge the quality of the obtained solution. The algorithm was programmed for a VAX 11/780. Problems with a size as the one described are solved in 30 CPU minutes. The value of the obtained solutions, when 35% of the produced energy is hydroelectric, is typically 4% away from its respective inferior elevations. [Spanish] Se presenta un metodo para encontrar una solucion aproximada al problema de asignacion de unidades hidroelectricas. El problema consiste en determinar, para cada uno de los intervalos del periodo de planeacion, cuales unidades hidroelectricas estaran en operacion y cuanto generaran, para que el costo de produccion de energia termoelectrica sea minimo. La solucion debe satisfacer ciertas politicas de operacion y restricciones de origen fisico

  19. ingénierie de base d'images, quelles procédures mettre en oeuvre ? L'exemple de la base d'images de la bibliothèque centrale du Muséum national d'histoire naturelle

    OpenAIRE

    Lenglet, Estel

    2012-01-01

    La réingénierie d'une base de données, notamment les bases d'images, pose la question des processus à suivre. Ce mémoire, rédigé à partir d'un stage au sein des bibliothèques du Muséum national d'histoire naturelle, a pour objectif de déterminer des procédures à mettre en place au cours de la réingénierie, mais également pour l'alimentation courante de la future base d'images. Après une étude du contexte et de l'existant, ce mémoire propose des procédures à appliquer dans le cadre de la gesti...

  20. How Inge Lehmann Discovered the Inner Core of the Earth

    Science.gov (United States)

    Rousseau, Christiane

    2013-01-01

    The mathematics behind Inge Lehmann's discovery that the inner core of the Earth is solid is explained using data collected around the Earth on seismic waves and their travel time through the Earth.

  1. LACEwING: Lessons from a New Moving Group Code

    CERN Document Server

    Riedel, Adric R

    2015-01-01

    With all the new discoveries being made about nearby young stars, the ability to find new nearby young stars is as important as ever, and membership identification codes will continue to perform a vital role in scientific research. In the process of creating a new moving group membership identification code - LocAting Constituent mEmbers In Nearby Groups (LACEwING) - we have discovered a few pointers relevant to astronomers trying to use codes like LACEwING to locate young stars.

  2. 78 FR 39023 - ING Investments, LLC, et al.;

    Science.gov (United States)

    2013-06-28

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION ING Investments, LLC, et al.; Notice of Application June 24, 2013. AGENCY: Securities and Exchange... shareholder approval. \\1\\ Portfolio Partners, Inc., et al., Investment Company Act Release Nos. 25558 (Apr....

  3. 75 FR 10230 - Inglis Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting Motions To...

    Science.gov (United States)

    2010-03-05

    ... Rousseau and Inglis dam, within the town of Inglis, in Levy, Citrus, and Marion counties, Florida. No... surface elevation of Lake Rousseau at 27.5 feet mean sea level. Flow releases would be determined by...

  4. Immediate relation of ING to fast breeder reactor programs

    International Nuclear Information System (INIS)

    The future large-scale use of nuclear energy is linked in the United States and other major countries to their fast breeder reactor development. Very serious basic problems have been discovered within the last two years, limiting the life in the high fast neutron flux at appropriate temperatures of materials, in particular of metals suitable for fuel cladding in sodium coolant. There is therefore a most urgent need for materials testing facilities under controlled conditions of temperature and neutron flux at sufficiently high ratings to match or surpass those required in commercially competitive fast breeder reactors. None of the test facilities yet planned for 1976 or sooner in the western world appears to match these conditions. The problem is mainly the difficulty of providing the high neutron flux effectively continuously. The spallation reaction in heavy elements was chosen as the basis of ING - the intense neutron generator, because it is the only known reaction that promises a fast neutron source density that is higher than can be controlled from the fission process. It is suggested that several countries will wish to consider urgently whether they should also explore the spallation reaction for the purpose of a fast neutron irradiation test facility. In view of the discontinuance of the ING project in Canada a favourable opportunity will exist over the next few months 10 obtain from Canada by direct personal contact details of the significant study that has been carried on for ING over the last five years. In the event that satisfactory materials are established within the lifetime of the spallation facilities they may continue to be used for the production of selected isotopes more profitably produced in high neutron fluxes. The facilities may be also used for the desirable preirradiation of thorium reactor fuel. The other research purposes planned for ING could also be served. (author)

  5. The ING1b tumor suppressor facilitates nucleotide excision repair by promoting chromatin accessibility to XPA

    International Nuclear Information System (INIS)

    ING1b is the most studied ING family protein and perhaps the most ubiquitously and abundantly expressed. This protein is involved in the regulation of various biological functions ranging from senescence, cell cycle arrest, apoptosis, to DNA repair. ING1b is upregulated by UV irradiation and enhances the removal of bulky nucleic acid photoproducts. In this study, we provide evidence that ING1b mediates nucleotide excision repair by facilitating the access to damaged nucleosomal DNA. We demonstrate that ING1b is not recruited to UV-induced DNA lesions but enhances nucleotide excision repair only in XPC-proficient cells, implying an essential role in early steps of the 'access, repair, restore' model. We also find that ING1b alters histone acetylation dynamics upon exposure to UV radiation and induces chromatin relaxation in microccocal nuclease digestion assay, revealing that ING1b may allow better access to nucleotide excision repair machinery. More importantly, ING1b associates with chromatin in a UV-inducible manner and facilitates DNA access to nucleotide excision repair factor XPA. Furthermore, depletion of the endogenous ING1b results to the sensitization of cells at S-phase to UV irradiation. Taken together, these observations establish a role of ING1b acting as a chromatin accessibility factor for DNA damage recognition proteins upon genotoxic injury

  6. Radioprotection et ingénierie nucléaire

    CERN Document Server

    2006-01-01

    Le développement de l'énergie nucléaire repose sur deux piliers essentiels : la sûreté nucléaire, qui concerne la machine, et la radioprotection, qui se préoccupe des hommes. Construit de manière fiable, un réacteur nucléaire se doit d'irradier le moins possible ses opérateurs et conduire à un impact très faible pour les populations avoisinantes. Tout cela est soumis à des règles strictes, élaborées au niveau international, et qui ne tolèrent aucun écart. Les ingénieurs qui ont à concevoir, construire et conduire ces machines doivent maîtriser les règles de protection : cet ouvrage leur est destiné. La radioprotection, si elle se fonde principalement sur des bases scientifiques, intègre également une dimension sociétale exigeante. Ces activités sont en effet sous le regard critique et permanent de nos concitoyens, qui exigent des acteurs de cette industrie une maîtrise totale de la radioprotection ; un ingénieur qui ne connaîtrait pas la genèse de la radioprotection, ses règle...

  7. Ingénierie et réingénierie des EIAH - L'approche REDiM

    OpenAIRE

    Choquet, Christophe

    2007-01-01

    Ce document présente nos recherches dans le domaine des EIAH (Environnements Informatiques pour l'Apprentissage Humain). Ces travaux se sont structurés en tant que projet scientifique impliquant plusieurs chercheurs. Ce projet, REDiM (Réingénierie des EIAH Dirigée par les Modèles), a pour objectif d'intégrer les enseignants et les formateurs de terrain dans le processus de conception d'un EIAH. La posture scientifique générale est de considérer la conception comme continue, supportée par un p...

  8. La Direction centrale de la statistique et la « Balance de l’économie nationale de l’URSS en 1923-24 » : la contribution de Pavel Illitch Popov à la théorie et à l’ingénierie de la planification économique.

    OpenAIRE

    Akhabbar, Amanar

    2014-01-01

    La Direction centrale de la statistique soviétique, la TsSOU, est créée en 1918 avec le soutien de Lénine. Pavel Illitch Popov en est le premier directeur (1918-1926). Centralisant le système régional des zemstva hérité du régime tsariste, la TsSOU est le cœur névralgique de la statistique soviétique pendant la NEP avant d’être dominée puis absorbée par le Gosplan. A la TsSOU, Popov défend sa vision d’une statistique qui, au service de la révolution et de la dictature du prolétariat, est scie...

  9. ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53.

    Directory of Open Access Journals (Sweden)

    Ulrike Linzen

    Full Text Available Inhibitor of growth (ING proteins have multiple functions in the control of cell proliferation, mainly by regulating processes associated with chromatin regulation and gene expression. ING5 has been described to regulate aspects of gene transcription and replication. Moreover deregulation of ING5 is observed in different tumors, potentially functioning as a tumor suppressor. Gene transcription in late G1 and in S phase and replication is regulated by cyclin-dependent kinase 2 (CDK2 in complex with cyclin E or cyclin A. CDK2 complexes phosphorylate and regulate several substrate proteins relevant for overcoming the restriction point and promoting S phase. We have identified ING5 as a novel CDK2 substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E/CDK2 and cyclin A/CDK2 in vitro. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate. Furthermore overexpression of cyclin E/CDK2 stimulates while the CDK2 inhibitor p27KIP1 represses phosphorylation at threonine 152. This site is located in a bipartite nuclear localization sequence but its phosphorylation was not sufficient to deregulate the subcellular localization of ING5. Although ING5 interacts with the tumor suppressor p53, we could not establish p53-dependent regulation of cell proliferation by ING5 and by phospho-site mutants. Instead we observed that the knockdown of ING5 resulted in a strong reduction of proliferation in different tumor cell lines, irrespective of the p53 status. This inhibition of proliferation was at least in part due to the induction of apoptosis. In summary we identified a phosphorylation site at threonine 152 of ING5 that is cell cycle regulated and we observed that ING5 is necessary for tumor cell proliferation, without any apparent dependency on the tumor suppressor p53.

  10. 77 FR 58375 - Inglis Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2012-09-20

    ... Energy Regulatory Commission Inglis Hydropower, LLC; Notice of Preliminary Permit Application Accepted..., Inglis Hydropower, LLC filed an application for a preliminary permit, pursuant to section 4(f) of the Federal Power Act (FPA), proposing to study the feasibility of a hydropower project located at the...

  11. 75 FR 65620 - Inglis Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting...

    Science.gov (United States)

    2010-10-26

    ... spillway on the Withlacoochee River, west of Lake Rousseau and Inglis Dam, within the town of Inglis and... flows released by the Southwest Water Management District from Lake Rousseau which is typically operated to maintain the water surface elevation of Lake Rousseau at 27.5 feet mean sea level. The...

  12. Inges Kindlustus kukkus kahjumisse. Kindlustushindade alandamata jätmine viis miinusesse / Kadrin Karner

    Index Scriptorium Estoniae

    Karner, Kadrin

    2011-01-01

    Inges Kindlustuse kahjumi põhjustas kõrgema hinnataseme säilitamine ning juhatuse liikmele välja makstud märkimisväärne tasu. Konkurentide RSA Kindlustus, Ergo Kindlustuse AS ja IF Kindlustus majandustulemused

  13. ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth

    OpenAIRE

    Satbir Thakur; Xiaolan Feng; Zhong Qiao Shi; Amudha Ganapathy; Manoj Kumar Mishra; Peter Atadja; Don Morris; Karl Riabowol

    2012-01-01

    BACKGROUND: Inhibitor of Growth (ING) proteins are epigenetic "readers" that recognize trimethylated lysine 4 of histone H3 (H3K4Me3) and target histone acetyl transferase (HAT) and histone deacetylase (HDAC) complexes to chromatin. METHODS AND PRINCIPAL FINDINGS: Here we asked whether dysregulating two epigenetic pathways with chemical inhibitors showed synergistic effects on breast cancer cell line killing. We also tested whether ING1 could synergize better with chemotherapeutics that targe...

  14. ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth

    Science.gov (United States)

    Thakur, Satbir; Feng, Xiaolan; Qiao Shi, Zhong; Ganapathy, Amudha; Kumar Mishra, Manoj; Atadja, Peter; Morris, Don; Riabowol, Karl

    2012-01-01

    Background Inhibitor of Growth (ING) proteins are epigenetic “readers” that recognize trimethylated lysine 4 of histone H3 (H3K4Me3) and target histone acetyl transferase (HAT) and histone deacetylase (HDAC) complexes to chromatin. Methods and Principal Findings Here we asked whether dysregulating two epigenetic pathways with chemical inhibitors showed synergistic effects on breast cancer cell line killing. We also tested whether ING1 could synergize better with chemotherapeutics that target the same epigenetic mechanism such as the HDAC inhibitor LBH589 (Panobinostat) or a different epigenetic mechanism such as 5-azacytidine (5azaC), which inhibits DNA methyl transferases. Simultaneous treatment of breast cancer cell lines with LBH589 and 5azaC did not show significant synergy in killing cells. However, combination treatment of ING1 with either LBH589 or 5azaC did show synergy. The combination of ING1b with 5azaC, which targets two distinct epigenetic mechanisms, was more effective at lower doses and enhanced apoptosis as determined by Annexin V staining and cleavage of caspase 3 and poly-ADP-ribose polymerase (PARP). ING1b plus 5azaC also acted synergistically to increase γH2AX staining indicating significant levels of DNA damage were induced. Adenoviral delivery of ING1b with 5azaC also inhibited cancer cell growth in a murine xenograft model and led to tumor regression when viral concentration was optimized in vivo. Conclusions These data show that targeting distinct epigenetic pathways can be more effective in blocking cancer cell line growth than targeting the same pathway with multiple agents, and that using viral delivery of epigenetic regulators can be more effective in synergizing with a chemical agent than using two chemotherapeutic agents. This study also indicates that the ING1 epigenetic regulator may have additional activities in the cell when expressed at high levels. PMID:22916295

  15. ING1 and 5-azacytidine act synergistically to block breast cancer cell growth.

    Directory of Open Access Journals (Sweden)

    Satbir Thakur

    Full Text Available BACKGROUND: Inhibitor of Growth (ING proteins are epigenetic "readers" that recognize trimethylated lysine 4 of histone H3 (H3K4Me3 and target histone acetyl transferase (HAT and histone deacetylase (HDAC complexes to chromatin. METHODS AND PRINCIPAL FINDINGS: Here we asked whether dysregulating two epigenetic pathways with chemical inhibitors showed synergistic effects on breast cancer cell line killing. We also tested whether ING1 could synergize better with chemotherapeutics that target the same epigenetic mechanism such as the HDAC inhibitor LBH589 (Panobinostat or a different epigenetic mechanism such as 5-azacytidine (5azaC, which inhibits DNA methyl transferases. Simultaneous treatment of breast cancer cell lines with LBH589 and 5azaC did not show significant synergy in killing cells. However, combination treatment of ING1 with either LBH589 or 5azaC did show synergy. The combination of ING1b with 5azaC, which targets two distinct epigenetic mechanisms, was more effective at lower doses and enhanced apoptosis as determined by Annexin V staining and cleavage of caspase 3 and poly-ADP-ribose polymerase (PARP. ING1b plus 5azaC also acted synergistically to increase γH2AX staining indicating significant levels of DNA damage were induced. Adenoviral delivery of ING1b with 5azaC also inhibited cancer cell growth in a murine xenograft model and led to tumor regression when viral concentration was optimized in vivo. CONCLUSIONS: These data show that targeting distinct epigenetic pathways can be more effective in blocking cancer cell line growth than targeting the same pathway with multiple agents, and that using viral delivery of epigenetic regulators can be more effective in synergizing with a chemical agent than using two chemotherapeutic agents. This study also indicates that the ING1 epigenetic regulator may have additional activities in the cell when expressed at high levels.

  16. ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.

    Science.gov (United States)

    Zhang, Feng; Zhang, Xutao; Meng, Jin; Zhao, Yong; Liu, Xinli; Liu, Yanxia; Wang, Yukun; Li, Yuhua; Sun, Yang; Wang, Zhipeng; Mei, Qibing; Zhang, Tao

    2015-06-30

    The proteins of the Inhibitor of Growth (ING) candidate tumor suppressor family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 is the new member of the family whose actual role in tumor suppression is not known. Here we show that ING5 overexpression in lung cancer A549 cells inhibited cell proliferation and invasiveness, while ING5 knockdown in lung cancer H1299 cells promoted cell aggressiveness. ING5 overexpression also abrogated tumor growth and invasive abilities of lung cancer cells in mouse xenograft models. Further study showed that ING5 overexpression inhibited EMT indicated by increase of E-cadherin and decrease of N-cadherin, Snail and slug at mRNA and protein levels, which was accompanied with morphological changes. cDNA microarray and subsequent qRT-PCR validation revealed that ING5 significantly downregulated expression of EMT (epithelial to mesenchymal transition)-inducing genes including CEACAM6, BMP2 and CDH11. Clinical study by tissue microarray showed that nuclear ING5 negatively correlated with clinical stages and lymph node metastasis of lung cancer. Furthermore, high level of nuclear ING5 was associated with a better prognosis. Taken together, these findings uncover an important role for ING5 as a potent tumor suppressor in lung cancer growth and metastasis. PMID:25938545

  17. De quels ingénieurs parle-t-on ? Situation et trajectoires des ingénieurs des grandes écoles. Le cas du Maroc

    Directory of Open Access Journals (Sweden)

    Pierre Vermeren

    2009-05-01

    Full Text Available Cet article est consacré au cas des « ingénieurs de conception » marocains, formés la plupart du temps dans les grandes écoles françaises. Cette fraction des ingénieurs marocains (dont la majorité est formée dans les écoles d'ingénieurs du Maroc n'est pas loin de constituer une véritable aristocratie de fonction. Ce phénomène illustre la structure sociale très inégalitaire du Maroc et la stratification opérée par la monarchie (le Makhzen pour sélectionner ses élites, qui sont aujourd'hui des élites à la fois technocratiques et sociales. Cette domination des « technocrates » sur l'appareil d'Etat marocain, analysée ici à travers des publics étudiants de grandes écoles, s'accompagne de l'émergence d'une contre-élite sociale de contestation. Les écoles d'ingénieurs de second rang, peuplées par les éléments des classes moyennes, ont été le premier terreau des mouvements islamistes en milieu universitaire. Elles produisent aujourd'hui une contre-élite politique et sociale qui piétine aux portes du vrai pouvoir.

  18. L'ingénierie des connaissances, entre science de l'information et science de gestion

    OpenAIRE

    Charlet, Jean

    2004-01-01

    Dans cet article, nous voulons expliciter et analyser les méthodes de l'ingénierie des connaissances. Nous voulons aussi étudier la position des outils de l'ingénierie des connaissances par rapport à l'organisation et aux sciences de gestion. Pour cela, nous pensons qu'il est nécessaire de revenir sur les fondements des systèmes à base de connaissances issus de l'ingénierie des connaissances et de l'intelligence artificielle pour positionner l'ingénierie des connaissances au sein des sciences...

  19. LACEwING: LocAting Constituent mEmbers In Nearby Groups

    Science.gov (United States)

    Riedel, Adric R.

    2016-01-01

    LACEwING (LocAting Constituent mEmbers In Nearby Groups) uses the kinematics (positions and motions) of stars to determine if they are members of one of 10 nearby young moving groups or 4 nearby open clusters within 100 parsecs. It is written for Python 2.7 and depends upon Numpy, Scipy, and Astropy (ascl:1304.002) modules. LACEwING can be used as a stand-alone code or as a module in other code. Additional python programs are present in the repository for the purpose of recalibrating the code and producing other analyses, including a traceback analysis.

  20. BE-ing @Work: Wearables and Presence of Mind in the Workplace

    Science.gov (United States)

    Forbes Oste, Heidi

    2016-01-01

    Expectations and demands in the changing contemporary workplace are driven by emergent technologies. Ubiquitous in nature, they are designed to enhance human and organization potential. These technologies provide access to information and connection at all times. They are increasingly reliant on human relationships and connection. BE-ing one's…

  1. Ad-ING4-IRES-IL-24双基因共表达载体的构建及表达%Construction and expression of adenovirus-mediated ING4 and IL-24 co-expression

    Institute of Scientific and Technical Information of China (English)

    盛伟华; 谢宇锋; 缪竞诚; 顾范博; 单云波; 朱晔涵; 陈华昕; 杜贤荣; 杨吉成

    2011-01-01

    目的:构建IRES介导的携带人肿瘤生长抑制因子4(ING4)和人白介素24(IL-24)双基因的重组腺病毒共表达载体(简称为Ad-ING4-IRES-IL-24),研究其表达产物对A549肺癌细胞生长的影响.方法:将PCR扩增的IRES、ING4和IL-24基因片段分别插入pAdTrack-CMV载体中构建pAdTrack-CMV-ING4-IRES-IL-24双基因共表达重组转移载体.按腺病毒载体常规构建方法获得同源重组腺病毒质粒pAdEasy-1-pAdTrack-CMV-ING4-IRES-IL-24,并在QBI-293A包装细胞中进行包装和病毒扩增.将扩增后的Ad-ING4-IRES-IL-24腺病毒感染A549肺癌细胞,并用RT-PCR和Western blot法鉴定ING4和IL-24基因在QBI-293A细胞或A549肺癌细胞中的表达,MTT法和流式细胞仪检测其对A549肺癌细胞生长抑制和诱导凋亡的功能和抑癌增效作用.结果:DNA测序结果显示pAdTrack-CMV转移载体中插入的ING4、IRES和IL-24片段的序列与GenBank报道的完全一致,Ad-ING4-IRES-IL-24能成功介导ING4和IL-24基因在QBI-293A和A549细胞中表达,不仅能明显抑制A549肺癌细胞生长和诱导其凋亡(72小时生长抑制率为62.82%±0.65%,凋亡率为19.40%±1.29%),而且与Ad-ING4-IRES(72小时生长抑制率为42.31%±0.43%,凋亡率为13.30%±1.85%)和Ad-IRES-IL-24单基因组(72小时生长抑制率为47.44%±0.39%,凋亡率为12.40%±1.05%)相比具有显著性差异(P<0.05).结论:成功构建了IRES介导的Ad-ING4-IL-24双基因共表达重组腺病毒载体,Ad-ING4-IL-24不仅能明显抑制A549肺癌细胞生长和诱导其凋亡,而且与Ad-ING4和AdIL-24单基因组相比具有抑癌增效作用.%Objective:To construct a recombinant adenoviral vector canying and co-expressing human inhibitor of growth 4(ING 4) and human interleukin-24(IL-24) mediated by internal ribosome entry site(IRES)(referred to as Ad-ING4-IRES-IL-24)and explore its effect on the growth of A549 human lung carcinoma cells in vitro.Methods:The IRES,ING4,and IL-24 fragments were amplified by PCR using p

  2. Penser la chaîne d'ingénierie territoriale

    OpenAIRE

    Trognon, Laurent

    2011-01-01

    La notion de chaîne d‟ingénierie est récente. Revue de la littérature retrace sa construction. Ses analogies avec les concepts de filières et de supply chain son étudiés. Une vision de cette chaîne combinant gouvernance, management, ingénierie et intelligence territoriale au service du développement territorial est proposée. Penser la CIT, aujourdhui, s‟est oser porter un regard managérial sur l‟organisation qu‟elle constitue, afin d‟accompagner le développement de son ingenium au service des...

  3. Les premiers ingénieurs du son français

    OpenAIRE

    Barnier, Martin

    2014-01-01

    Comment la profession des ingénieurs du son s’est-elle créée en France ? On constate que la formation s’est faite principalement sur le tas. La transmission s’est effectuée d’abord avec les anciens du laboratoire Gaumont (première institution à avoir travaillé régulièrement sur le son). Puis viennent les ingénieurs du son étrangers qui transmettent leur savoir lors de la généralisation du parlant. Le travail dans les studios de « dubbing » (doublage) et les liens entre les plateaux et les ind...

  4. Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer.

    Science.gov (United States)

    Zhang, H; Zhou, X; Xu, C; Yang, J; Xiang, J; Tao, M; Xie, Y

    2016-01-01

    Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog (PTEN) have been shown to be strong candidate tumor suppressors. However, the combined efficacy of ING4 and PTEN for human gastric cancer remains to be determined. In this report, we constructed a multiple promoter expression cassette-based recombinant adenovirus coexpressing ING4 and PTEN (AdVING4/PTEN), assessed the combined effects of AdVING4/PTEN on gastric cancer using wild-type p53 AGS and SNU-1 human gastric cancer cell lines, and elucidated its underlying mechanisms. We found that AdVING4/PTEN-induced synergistic growth inhibition and apoptosis in vitro AGS or SNU-1 tumor cells and in vivo AGS xenografted tumors subcutaneously inoculated in athymic BALB/c nude mice. Mechanistically, AdVING4/PTEN exhibited an enhanced effect on upregulation of p53, Ac-p53 (K382), P21, Bax, PUMA, Noxa, cleaved Caspase-9, cleaved Caspase-3 and cleaved PARP as well as downregulation of Bcl-2 in vitro and in vivo. In addition, AdVING4/PTEN synergistically downregulated tumor vessel CD34 expression and reduced microvessel density, and additively inhibited vascular endothelial growth factor (VEGF) expression in vivo. The synergistic tumor suppression elicited by AdVING4/PTEN was closely associated with the synergistic induction of apoptosis possibly via enhancement of endogenous p53 responses through cooperatively facilitating p53's stability and acetylation, and the synergistic inhibition of tumor angiogenesis probably via overlapping reduction of VEGF through cooperatively downregulating hypoxia inducible factor-1α's level and transcription activity. Thus, our results indicate that cancer gene therapy combining ING4 and PTEN may constitute a novel and effective therapeutic modality for human gastric cancer and other cancers. PMID:26564429

  5. Excel pour l'ingénieur bases, graphiques, calculs, macros, VBA

    CERN Document Server

    Bellan, Philippe

    2010-01-01

    Excel, utilisé par tout possesseur d'un ordinateur personnel pour effectuer des manipulations élémentaires de tableaux et de chiffres, est en réalité un outil beaucoup plus puissant, aux potentialités souvent ignorées. A tous ceux, étudiants scientifiques, élèves-ingénieurs ou ingénieurs en exercice qui pensaient le calcul numérique seulement possible à travers des logiciels lourds et coûteux, ce livre montrera qu'un grand nombre de problèmes mathématiques courants de l'ingénieur peuvent être résolus numériquement en utilisant les outils de calcul et la capacité graphique d'Excel. A cet effet, après avoir introduit les notions de base, l'ouvrage décrit les fonctions disponibles avec Excel, puis quelques méthodes numériques simples permettant de calculer des intégrales, de résoudre des équations différentielles, d'obtenir les solutions de systèmes linéaires ou non, de traiter des problèmes d'optimisation... Les méthodes numériques présentées, qui sont très simples, peuvent...

  6. The 'Techniques de l'ingénieur' available online at CERN!

    CERN Multimedia

    2001-01-01

    Those already familiar with 'Techniques de l'ingénieur' will be delighted. This engineering technology database widely known among French-speaking engineers and technicians can now be consulted online from the CERN Intranet until the end of the summer. To access this database of reference articles in French, all you need to do is go to the CERN Library's Web pages (http://library.cern.ch) and click on the 'Techniques de l'ingénieur' link under the 'News' heading. The Library will be monitoring the use of the database for a couple of months, at the end of which an access licence may be negotiated. Don't hesitate to use it because the decision whether or not to purchase it will depend on the extent to which it is used. The Library is seeking partners within the Laboratory to finance the purchase if it is decided to go ahead with it. Contributions from the CERN community are therefore welcome. For those who are not yet familiar with it, the 'Techniques de l'ingénieur' database ...

  7. The ING Seismic Network Databank (ISND : a friendly parameters and waveform database

    Directory of Open Access Journals (Sweden)

    G. Smriglio

    1995-06-01

    Full Text Available he Istituto Nazionale di Geofisica (ING Seismic Network Database (ISND includes over 300000 arrivaI times of Italian, Mediterranean and teleseismic earthquakes from 1983 to date. This database is a useful tool for Italian and foreign seismologists ( over 1000 data requests in the first 6 months of this year. Recently (1994 the ING began storing in the ISND, the digital waveforms associated with arri,Tal times and experimen- tally allowed users to retrieve waveforms recorded by the ING acquisition system. In this paper we describe the types of data stored and the interactive and batch procedures available to obtain arrivaI times and/or asso- ciated waveforms. The ISND is reachable via telephone line, P.S.I., Internet and DecNet. Users can read and send to their E-mail address alI selected earthquakes locations, parameters, arrivaI times and associated digital waveforms (in SAC, SUDS or ASCII format. For r;aedium or large amounts of data users can ask to receive data by means of magnetic media (DAT, Video 8, floppy disk.

  8. Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.

    Science.gov (United States)

    Ren, Xin; Liu, Hao; Zhang, Mingjie; Wang, Mengjun; Ma, Shiyin

    2016-09-01

    Hypopharyngeal cancer is a distinct type of malignant head and neck tumor, which exhibits low sensitivity to anti-cancer drugs. The importance of developing methods for reducing chemotherapy resistance, and improving and enhancing prognosis has previously been emphasized and is considered a challenge for effective clinical treatment of hypopharyngeal cancer. The current study investigated the effects of co‑expression of inhibitor of growth protein 4 (ING4) and P53, a tumor suppressor gene, on chemosensitivity to cisplatin in human hypopharyngeal cancer xenografts in vivo, and the potential molecular mechanisms involved. A tumor model was established by injecting athymic nude mice with FADU human hypopharyngeal cancer cells. Five days after intratumoral and peritumoral injections of an empty adenoviral vector (Ad), Ad‑ING4‑P53, cisplatin, or a combination of Ad‑ING4‑P53 and cisplatin (Ad‑ING4‑P53 + cisplatin) every other day for 5 days, the mice were euthanized and their tumors, livers, and kidneys were removed. The tumor weights were used to calculate the inhibition rate, and the expression levels of ING4 and P53 were detected by reverse transcription‑polymerase chain reaction. Additionally, apoptotic cells were detected using terminal deoxynucleotidyl transferase dUTP nick end labeling, and immunohistochemistry determined the levels ING4, P53, B‑cell lymphoma‑2 (Bcl‑2) and Bcl‑2 associated X protein (Bax) protein expression. The results demonstrated increased expression of ING4 and P53 in the Ad‑ING4‑P53 groups compared with PBS and Ad groups, indicating successful introduction of the genes into the tumor cells. Notably, the Ad‑ING4‑P53 + cisplatin group exhibited a higher inhibition rate compared with the four other groups. The results of immunohistochemistry analysis demonstrated that Bax expression was increased and Bcl‑2 was decreased in the Ad‑ING4‑P53 + cisplatin group. This suggested that the enhanced

  9. Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis

    OpenAIRE

    Froudarakis Marios; Sotiriou Ioannis; Steiropoulos Paschalis; Konstantinou Fotios; Mikroulis Dimitrios; Zacharis George; Karameris Andreas; Harokopos Vagelis; Aidinis Vassilis; Tzouvelekis Argyris; Pneumatikos Ioannis; Tringidou Rodoula; Bouros Demosthenes

    2009-01-01

    Abstract Background Recent evidence has underscored the role of hypoxia and angiogenesis in the pathogenesis of idiopathic fibrotic lung disease. Inhibitor of growth family member 4 (ING4) has recently attracted much attention as a tumor suppressor gene, due to its ability to inhibit cancer cell proliferation, migration and angiogenesis. The aim of our study was to investigate the role of ING4 in the pathogenesis of pulmonary fibrosis both in the bleomycin (BLM)-model and in two different typ...

  10. The inhibitor of growth protein 5 (ING5 depends on INCA1 as a co-factor for its antiproliferative effects.

    Directory of Open Access Journals (Sweden)

    Feng Zhang

    Full Text Available The proteins of the Inhibitor of Growth (ING family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. For ING5, its actual role in growth suppression and the necessary partners are not known. In a yeast-two-hybrid approach with human bone marrow derived cDNA, we identified ING5 as well as several other proteins as interaction partners of Inhibitor of cyclin A1 (INCA1 that we previously characterized as a novel interaction partner of cyclin A1/CDK2. ING5 expression in leukemic AML blasts was severely reduced compared to normal bone marrow. In line, ING5 inhibited bone marrow colony formation upon retroviral transduction. However, Inca1(-/- bone marrow colony formation was not suppressed by ING5. In murine embryonic fibroblast (MEF cells from Inca1(+/+ and Inca1(-/- mice, overexpression of ING5 suppressed cell proliferation only in the presence of INCA1, while ING5 had no effect in Inca1(-/- MEFs. ING5 overexpression induced a delay in S-phase progression, which required INCA1. Finally, ING5 overexpression enhanced Fas-induced apoptosis in Inca1(+/+ MEFs, while Inca1(-/- MEFs were protected from Fas antibody-induced apoptosis. Taken together, these results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.

  11. Crystallization and preliminary X-ray diffraction analysis of the dimerization domain of the tumour suppressor ING4

    International Nuclear Information System (INIS)

    The N-terminal domain of ING4 was overexpressed in Escherichia coli and purified to homogeneity. Crystallization experiments yielded crystals that were suitable for high-resolution X-ray diffraction analysis. Inhibitor of growth protein 4 (ING4) belongs to the ING family of tumour suppressors and is involved in chromatin remodelling, in growth arrest and, in cooperation with p53, in senescence and apoptosis. Whereas the structure and histone H3-binding properties of the C-terminal PHD domains of the ING proteins are known, no structural information is available for the N-terminal domains. This domain contains a putative oligomerization site rich in helical structure in the ING2–5 members of the family. The N-terminal domain of ING4 was overexpressed in Escherichia coli and purified to homogeneity. Crystallization experiments yielded crystals that were suitable for high-resolution X-ray diffraction analysis. The crystals belonged to the orthorhombic space group C222, with unit-cell parameters a = 129.7, b = 188.3, c = 62.7 Å. The self-rotation function and the Matthews coefficient suggested the presence of three protein dimers per asymmetric unit. The crystals diffracted to a resolution of 2.3 Å using synchrotron radiation at the Swiss Light Source (SLS) and the European Synchrotron Radiation Facility (ESRF)

  12. 皮肤鳞状细胞癌组织中p33ING1蛋白的表达%p33ING1 Gene Expression in Cutaneous Squamous Cell Carcinoma

    Institute of Scientific and Technical Information of China (English)

    姚莹

    2014-01-01

    Objective To investigate the expression of p33ING1 protein rate in skin squamous cell carcinoma and their clinical signiifcance. Methods All samples of normal and cancer tissues from 95 patients were detected for their protein expression levels of p33ING1 with the SP immunohistochemical staining. Results The positive rate of p33ING1 in cutaneous squamous cell carcinoma was 42.9%, signiifcantly lower than that of normal skin tissue 82.9%, P<0.05. The expression of p33ING1 was lower in Bowen disease tissues (56%) than that of normal tissues (82.9%). Conclusion The low expression of p33ING1 in carcinoma may be important fators related to carcinogenesis, development of cutaneous squamous cell carcinoma.%目的:研究p33ING1基因表达与皮肤鳞状细胞癌的发生、发展的关系。方法应用免疫组化检测我科在1999年~2004年35例皮肤鳞状细胞癌及25例原位鳞癌(Bowen病)组织中的p33ING1表达情况。结果皮肤鳞状细胞癌p33ING1蛋白表达阳性率为42.9%(15/35),明显低于正常组的82.9%(29/35),二者比较有明显差异性,χ2=11.99,P<0.05。其原位鳞癌中阳性表达为14(56%),同样明显低于正常组织的阳性率82.9%(29/35),二者比较有明显差异性,χ2=5.18,P<0.05。结论p33ING1蛋白在皮肤鳞状细胞癌组织中的表达下降,提示p33ING1蛋白在皮肤鳞状细胞癌的发生、进展有重要意义,并有可能成为肿瘤检测蛋白之一。

  13. Firemní kultura společnosti INGE Opava spol. s r.o.

    OpenAIRE

    Šimetková, Tereza

    2013-01-01

    This bachelor thesis deals with the corporate culture of INGE Opava spol. s r.o. The first part of the thesis is devoted to the issue of corporate culture in theory and the important concepts as well as the importance of corporate culture are explained. The practical part is focused on a specific company and its corporate culture. Firstly, the basic information about the company and the key elements of its corporate culture are described. Subsequently, an analysis of the corporate culture is ...

  14. The intense neutron generator INGE-1 at the Technical University of Dresden

    International Nuclear Information System (INIS)

    The INGE-1 neutron generator developed for intergal 14 MeV neutron experiments is described. The accelerator produces steady d+ ion beam in the current range of 1-10 mA with 120-240 keV energies at the target position. The beam is produced with a combined duoplasmatron focalization system on high voltage. A 30 keV beam is accelerated on final energy by a two-gap acceleration tube. The estimations conducted show that the generator maximum strength can reach up to 2x1012s-1 at 10 mA beam current and 220 keV energy. 4 refs

  15. Down-regulation of the inhibitor of growth family member 4 (ING4 in different forms of pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Froudarakis Marios

    2009-02-01

    Full Text Available Abstract Background Recent evidence has underscored the role of hypoxia and angiogenesis in the pathogenesis of idiopathic fibrotic lung disease. Inhibitor of growth family member 4 (ING4 has recently attracted much attention as a tumor suppressor gene, due to its ability to inhibit cancer cell proliferation, migration and angiogenesis. The aim of our study was to investigate the role of ING4 in the pathogenesis of pulmonary fibrosis both in the bleomycin (BLM-model and in two different types of human pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF and cryptogenic organizing pneumonia (COP. Methods Experimental model of pulmonary fibrosis was induced by a single tail vein injection of bleomycin in 6- to 8-wk-old C57BL/6mice. Tissue microarrays coupled with qRT-PCR and immunohistochemistry were applied in whole lung samples and paraffin-embedded tissue sections of 30 patients with IPF, 20 with COP and 20 control subjects. Results A gradual decline of ING4 expression in both mRNA and protein levels was reported in the BLM-model. ING4 was also found down-regulated in IPF patients compared to COP and control subjects. Immunolocalization analyses revealed increased expression in areas of normal epithelium and in alveolar epithelium surrounding Masson bodies, in COP lung, whereas showed no expression within areas of active fibrosis within IPF and COP lung. In addition, ING4 expression levels were negatively correlated with pulmonary function parameters in IPF patients. Conclusion Our data suggest a potential role for ING4 in lung fibrogenesis. ING4 down-regulation may facilitate aberrant vascular remodelling and fibroblast proliferation and migration leading to progressive disease.

  16. Hope for Central China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The cities surrounding Changsha and Wuhan in the middle reaches of the Yangtze River will ally to form a new pilot zone to boost regional economic development China’s fourth pilot zone for compre- hensive and coordinated economic reform will soon debut in the middle reaches of the Yangtze River,open- ing a new area to attract foreign investment. The application has been submitted to the State Council for approval. The pilot zone will include two clusters of cities in central China:One consists of Wuhan,capital of Hubei Province,and eight surrounding cities in Hubei,and the other is composed of Changsha,Zhuzhou and Xiangtan,three major cities in Hunan Province.

  17. MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity

    International Nuclear Information System (INIS)

    MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in human gastric cancer progression has been reported; however, the role of miR-650 in gastric cancer is poorly understood. In this study, we show that miR-650 is involved in lymphatic and distant metastasis in human gastric cancer, and we find that ectopic expression of miR-650 promotes tumorigenesis and proliferation of gastric cancer cells. A luciferase reporter assay demonstrates that Inhibitor of Growth 4 (ING4) is a direct target of miR-650. Collectively, our study demonstrates that over-expression of miR-650 in gastric cancer may promote proliferation and growth of cancer cells, at least partially through directly targeting ING4. These findings help clarify the molecular mechanisms involved in gastric carcinogenesis and indicate that miR-650 modulation may be a bona fide miRNA-based treatment of gastric cancer.

  18. LoopIng: a template-based tool for predicting the structure of protein loops.

    KAUST Repository

    Messih, Mario Abdel

    2015-08-06

    Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure. This implies that, unlike the rest of the protein, standard homology modeling techniques are not very effective in modeling their structure. However, loops are often involved in protein function, hence inferring their structure is important for predicting protein structure as well as function.We describe a method, LoopIng, based on the Random Forest automated learning technique, which, given a target loop, selects a structural template for it from a database of loop candidates. Compared to the most recently available methods, LoopIng is able to achieve similar accuracy for short loops (4-10 residues) and significant enhancements for long loops (11-20 residues). The quality of the predictions is robust to errors that unavoidably affect the stem regions when these are modeled. The method returns a confidence score for the predicted template loops and has the advantage of being very fast (on average: 1 min/loop).www.biocomputing.it/loopinganna.tramontano@uniroma1.itSupplementary data are available at Bioinformatics online.

  19. Quality of wooden chips produced by Claas Jaguar fitted with experimental CRA-ING rotor

    Energy Technology Data Exchange (ETDEWEB)

    Pari, L.; Civitarese, V.; Del Giudice, A. [Council for Research in Agriculture, Agricultural Engineering Research Unit, Rome (Italy)

    2010-07-01

    This paper described a newly developed chipper device for mounting on Claas Jaguar chipper harvesters for short rotation forestry harvesting. It was designed by the Agriculture Engineering Research Unit of the Agricultural Research Council in Rome, Italy. The new rotor has a lower number of blades compared to standard rotors and has a different cutting angle and drum insertion. This study evaluated the particle-size distribution of wood chips produced by standard rotors compared to those with the experimental rotor. The objective was to distinguish the particle size distribution of chips produced using the two types of chippers in order to evaluate the influence of wooden species in the chip formation process. Tests were conducted using 860 and 890 Claas Jaguar chipper harvesters, both equipped with standard and CRA-ING rotors. The experiment was conducted on poplar cultivations on biennial shift and on arboreal cultivations. Compared to traditional rotors, CRA-ING rotors provide a considerable product increase within particle sizes ranging from 12.5 to 25 mm, and an equivalent product reduction within the finest particle size classes. The study showed that the new rotor tends to concentrate dimensional increments along the longitudinal section of the chip, regardless of the species used. In order to obtain a better quality chip in terms of particle size, a second rotor was devised to engrave a cleaner cut on the biomass introduced by the feeding rollers.

  20. Techniques de l’ingénieur, a long-awaited resource

    CERN Multimedia

    GS Department

    2009-01-01

    Since 1 August 2009, a new online resource Les techniques de l’Ingénieur has been available at CERN: and its corpus of over 4,000 articles covering 11 disciplines is now accessible from your computer. This multidisciplinary database covers many subjects ranging from mechanics to the environment. The articles are written by scientific experts recognized in their fields. Online access includes the archives since 1946; it also serves to monitor the latest trends and innovations, and new industry products. This database is therefore both a valuable resource in past and present scientific and technological information and a tool to observe future developments. Anyone can create a free account on this resource. This account is needed to configure your personal alerts and download pdf files of the documents you are interested in. More information on the Library website. Direct access to the database

  1. Spre[ing amelanotic malignant melanoma: A rare differential diagnosis with tumors of the glandula submandibularis

    International Nuclear Information System (INIS)

    The case reported emphasizes the importance of immediate performance of imaging scans in case of the slightest suspicion that clinical symptoms might indicate malignancy of a detected lesion. Despite the superficially only marginal macroscopic findings, MR imaging as well as the CT scans revealed an [vanced, malignant process that h[ been spre[ing. Particularly the soft tissue differential diagnosis obtained with MRI yields the information required for diagnostic characterization of the space occupying tumor mass. It will however be necessary in any case to verify the diagnosis by biopsy or extirpation and cytologic examination of tissue, as the imaging methods do not always unambigiously reveal the malignant dignity of the tumor. (orig./CB)

  2. ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression

    Science.gov (United States)

    Gou, Wen-feng; Shen, Dao-fu; Yang, Xue-feng; Zhao, Shuang; Liu, Yun-peng; Sun, Hong-zhi; Su, Rong-jian; Luo, Jun-sheng; Zheng, Hua-chuan

    2015-01-01

    Here, we found that ING5 overexpression increased autophagy, differentiation, and decreased proliferation, apoptosis, migration, invasion and lamellipodia formation in gastric cancer cells, while ING5 knockdown had the opposite effects. In SGC-7901 transfectants, ING5 overexpression caused G1 arrest, which was positively associated with 14-3-3 overexpression, Cdk4 and c-jun hypoexpression. The induction of Bax hypoexpression, Bcl-2, survivin, 14-3-3, PI3K, p-Akt and p70S6K overexpression by ING5 decreased apoptosis in SGC-7901 cells. The hypoexpression of MMP-9, MAP1B and flotillin 2 contributed to the inhibitory effects of ING5 on migration and invasion of SGC-7901 cells. ING5 overexpression might activate both β-catenin and NF-κB pathways in SGC-7901 cells, and promote the expression of down-stream genes (c-myc, VEGF, Cyclin D1, survivin, and interleukins). Compared with the control, ING5 transfectants displayed drug resistance to triciribine, paclitaxel, cisplatin, SAHA, MG132 and parthenolide, which was positively related to their apoptotic induction and the overexpression of chemoresistance-related genes (MDR1, GRP78, GRP94, IRE, CD147, FBXW7, TOP1, TOP2, MLH1, MRP1, BRCP1 and GST-π). ING5 expression was higher in gastric cancer than matched mucosa. It was inversely associated with tumor size, dedifferentiation, lymph node metastasis and clinicopathological staging of cancer. ING5 overexpression suppressed growth, blood supply and lung metastasis of SGC-7901 cells by inhibiting proliferation, enhancing autophagy and apoptosis in xenograft models. It was suggested that ING5 expression might be employed as a good marker for gastric carcinogenesis and subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis. ING5 might induce apoptotic and chemotherapeutic resistances of gastric cancer cells by activating β-catenin, NF-κB and Akt pathways. PMID:25980581

  3. Linguistic Variation, Context, and Meaning: A Case of "-ing/in'" Variation in North American Workers' Speech.

    Science.gov (United States)

    Huspek, Michael R.

    1986-01-01

    Suggests an alternative approach to the variable rule method of accounting for linguistic variability. This alternative approach, which is sensitive to social context and the relevance of meaning, is used to support an analysis of "-ing/in'" variability in some North American industrial workers' speech. (SED)

  4. Warm isostatic pressing (WIP'ing) of GS44 Si3N4 FDC parts for defect removal

    International Nuclear Information System (INIS)

    Fused deposition of ceramics (FDC) is one of the developing solid freeform fabrication (SFF) techniques. The successful production of high performance ceramics by the FDC process requires that no defects exist in the green parts. However, build defects, such as missing roads, poorly bonded layers or sub-perimeter voids can be encountered in improperly built FDC parts. In this study, a method known as WIP'ing (warm isostatic pressing) was evaluated for its ability to eliminate existing defects in GS44 Si3N4 green FDC parts. Analogous to CIP'ing (cold isostatic pressing), the green FDC parts were rubber bagged and loaded into a pressure chamber filled with water soluble oil at different temperatures, ranging from 30 to 90 deg. C, at pressures of up to 35 MPa. X-Ray radiography results indicated that at temperatures above 70 deg. C, WIP'ing was effective in closing the gaps of the intentionally placed void defects in FDC parts. However, WIP'ing above 70 deg. C was not effective in healing the defects completely. The fracture strengths of FDC parts with intentional added defects, WIP'ed above 70 deg. C were substantially lower than control samples

  5. Algõpetuse peajoon ja harupedagoogikad / Sirje Piht, Elve Voltein, Anne Uusen, Inge Timoštšuk

    Index Scriptorium Estoniae

    2012-01-01

    Intervjuu Sirje Pihti ja Anne Uuseniga Tallinna Ülikooli algõpetuse osakonnast, Elve Volteiniga Tartu Ülikooli haridusteaduste instituudi õpetajate seminarist ja Inge Timoštšukiga Tallinna Ülikooli kasvatusteaduste instituudi pedagoogilise praktika keskusest

  6. ING-1(heMAb, a Monoclonal Antibody to Epithelial Cell Adhesion Molecule, Inhibits Tumor Metastases in a Murine Cancer Model

    Directory of Open Access Journals (Sweden)

    Harry H. Ruan

    2003-11-01

    Full Text Available ING-1(heMAb, a human-engineered monoclonal antibody (MAb that specifically targets the epithelial cell adhesion molecule (Ep-CAM, kills adenocarcinoma cells in vitro and inhibits tumor growth in vivo. In the current study, we evaluated the efficacy of ING-1(heMAb in a murine model of cancer metastases. Mice received intravenous dosing of 1 mg/kg ING-1(heMAb, twice a week, starting on day 2 or day 5. A negative control group received 1 mg/kg human immunoglobulin G with the same dose frequency starting on day 2. A positive control group received weekly 100 mg/kg 54lurouracil/leucovorin starting on day 2. ING-1(heMAb/day 2 treatment significantly reduced both the number of visible tumor nodules in body cavities (P < .01 and the number of metastases on lung surfaces (P < .005. The treatment also resulted in a 91% reduction of micrometastases in lung tissues (P <.0001. Delaying ING-1(heMAb treatment until day 5 caused 54% reduction in micrometastases (P <.005. Our results indicate that a number of parameters, including treatment starting day, dose level, and dose frequency, are critical in achieving the optimal efficacy of ING-1(heMAb. We conclude that ING-1(heMAb effectively reduced tumor metastases in a murine cancer model. Immunotherapy with ING-1(heMAb may be beneficial in treating human metastatic diseases.

  7. Adenovirus-mediated ING4 expression reduces multidrug resistance of human gastric carcinoma cells in vitro and in vivo.

    Science.gov (United States)

    Mao, Zong-Lei; He, Song-Bing; Sheng, Wei-Hua; Dong, Xiao-Qiang; Yang, Ji-Cheng

    2013-11-01

    Chemotherapy is the primary treatment for both resectable and advanced gastric carcinoma, yet multiple drug resistance (MDR) of gastric carcinoma remains a significant therapeutic obstacle. The development of novel strategies to reduce MDR in gastric carcinoma would yield a better outcome following chemotherapy. ING4, a member of the inhibitor of growth (ING) tumor-suppressor family, possesses antitumor and radiosensitization or chemosensitization effects in a variety of human cancers. The present study investigated the effects and possible mechanisms of action of adenovirus-mediated ING4 (AdVING4) on the reversion of human gastric carcinoma cell MDR in vitro and in vivo in nude mouse xenografts. The data showed that the expression of ING4 mRNA and protein was dramatically downregulated (or lost) in gastric carcinoma SGC7901/CDDP cells after CDDP-induced MDR phenotype and in the parental SGC7901 cells. AdVING4‑induced ING4 expression reversed MDR and induced apoptosis of SGC7901/CDDP cells in vitro and in vivo in the SGC7901/CDDP xenograft tumors. Furthermore, AdVING4 substantially downregulated the expression of MDR-related proteins P-gp and MRP1 and apoptosis‑related proteins Bcl-2 and survivin, but upregulated the expression of apoptosis-related protein Bax in the SGC7901/CDDP xenograft tissues. The reversion effects elicited by AdVING4 on gastric cancer cell MDR were closely associated with the downregulation of ATP-binding cassette transporters and activation of apoptotic pathways. Thus, these findings suggest that AdVING4 may be a feasible modulator for the MDR phenotype of gastric carcinoma cells. PMID:23969950

  8. Hnattvæðing: Kynjað eða kynblint ferli?

    OpenAIRE

    Helga Benediktsdóttir 1990

    2009-01-01

    Hnattvæðing hefur haft mismunandi áhrif á íbúa heimsins eftir til dæmis aldri, kynþætti, búsetu, samfélagsstöðu, menntun, fjárhagsstöðu og síðast en ekki síst kyni. Í þessari ritgerð skoða ég hvernig ferli hnattvæðingar hafa haft önnur áhrif á konur en karla. Ég skoða konur sem nýtt vinnuafl í launuðum störfum í þriðja heiminum, konur sem sölu- og neysluvöru í kynlífsiðnaði og konur sem landfræðilega hreyfanlegt vinnuafl þegar kemur að heimilis- og umönnunarstörfum. Ég skoða jafnframt hvort k...

  9. Démarche d'Ingénierie Système pour les systèmes de management.Application à l'ingénierie d'un processus de conception et développement

    OpenAIRE

    Bron, Jean-Yves; Salzemann, Bruno

    2015-01-01

    Le pôle AIP-PRIMECA Lorraine est un centre de ressources de l'Université de Lorraine, il met à disposition des filières de formation des plateformes à caractères industriels. Dans cette publication, nous proposons une démarche d'ingénierie d'un processus de son système de management. L'originalité de notre contribution repose principalement sur l'usage de méthodologies issues de l'Ingénierie des Systèmes Complexes pour la conception d'un processus d'un système de management. Ce dernier étant ...

  10. ING4在脑胶质瘤中的表达与curcumin治疗作用研究%ING4 expression in human gliomas and therapeutic role of curcumin on gliomas

    Institute of Scientific and Technical Information of China (English)

    刘恩渝; 章翔; 张剑宁; 刘卫平; 蒋晓帆

    2007-01-01

    目的 研究生长抑制因子4(ING4)在脑胶质瘤中的表达和姜黄素(curcumin)对脑胶质瘤的治疗作用,揭示curcumin抗脑胶质瘤作用的分子机制.方法 体外培养U251胶质瘤细胞并以不同浓度curcumin处理细胞;以药物敏感试验和流式细胞仪分别检测curcumin对胶质瘤细胞生长和细胞周期的影响,以DNA梯度凝胶电泳检测细胞凋亡,以Western blot分析curcumin处理后蛋白表达变化.结果 ING4蛋白在正常神经细胞中高表达,在U251细胞中几乎不表达.低剂量curcumin对U251细胞无明显抑制作用,而高剂量curcumin对U251细胞存在明显的生长抑制作用,生长抑制率达35%.10μM curcumin作用24 h后,U251细胞中ING4蛋白表达水平显著增加.结论 高剂量curcumin通过诱导ING4表达上调,抑制脑胶质瘤细胞体外生长.

  11. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

    Science.gov (United States)

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng

    2015-03-15

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1-Cul1-F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention. PMID:25792601

  12. Démarche d'Ingénierie Système pour les systèmes de management

    OpenAIRE

    Bron, Jean-Yves; Salzemann, Bruno

    2015-01-01

    Le pôle AIP-PRIMECA Lorraine est un centre de ressources de l'Université de Lorraine, il met à disposition des filières de formation des plateformes à caractères industriels. Dans cette publication, nous proposons une démarche d'ingénierie d'un processus de son système de management. L'originalité de notre contribution repose principalement sur l'usage de méthodologies issues de l'Ingénierie des Systèmes Complexes pour la conception d'un processus d'un système de management. Ce dernier étant ...

  13. 'HESPERIA' HORIZON 2020 project: High Energy Solar Particle Events foRecastIng and Analysis

    Science.gov (United States)

    Malandraki, Olga; Klein, Karl-Ludwig; Vainio, Rami; Agueda, Neus; Nunez, Marlon; Heber, Bernd; Buetikofer, Rolf; Sarlanis, Christos; Crosby, Norma; Bindi, Veronica; Murphy, Ronald; Tyka, Allan J.; Rodriguez, Juan

    2016-04-01

    Solar energetic particles (SEPs) are of prime interest for fundamental astrophysics. However, due to their high energies they are a space weather concern for technology in space as well as human space exploration calling for reliable tools with predictive capabilities. The two-year EU HORIZON 2020 project HESPERIA (High Energy Solar Particle Events foRecastIng and Analysis, http://www.hesperia-space.eu/) will produce two novel operational SEP forecasting tools based upon proven concepts (UMASEP, REleASE). At the same time the project will advance our understanding of the physical mechanisms that result into high-energy SEP events through the systematic exploitation of the high-energy gamma-ray observations of the FERMI mission and other novel published datasets (PAMELA, AMS), together with in situ SEP measurements near 1 AU. By using multi-frequency observations and performing simulations, the project will address the chain of processes from particle acceleration in the corona, particle transport in the magnetically complex corona and interplanetary space to their detection near 1 AU. Furthermore, HESPERIA will explore the possibility of incorporating the derived results into future innovative space weather services. Publicly available software to invert neutron monitor observations of relativistic SEPs to physical parameters, giving information on the high-energy processes occurring at or near the Sun during solar eruptions, will be provided for the first time. The results of this inversion software will complement the space-borne measurements at adjacent higher energies. In order to achieve these goals HESPERIA will exploit already existing large datasets that are stored into databases built under EU FP7 projects NMDB and SEPServer. The structure of the HESPERIA project, its main objectives and forecasting operational tools, as well as the added value to SEP research will be presented and discussed. Acknowledgement: This project has received funding from the

  14. The Inhibitor of Growth Protein 5 (ING5) Depends on INCA1 as a Co-Factor for Its Antiproliferative Effects

    OpenAIRE

    Zhang, F.; Bäumer, N. (Nicole); M. Rode; Ji, P.; Zhang, T.; Berdel, W. E.; Müller-Tidow, C

    2011-01-01

    The proteins of the Inhibitor of Growth (ING) family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. For ING5, its actual role in growth suppression and the necessary partners are not known. In a yeast-two-hybrid approach with human bone marrow derived cDNA, we identified ING5 as well as several other proteins as interaction partners of Inhibitor of cyclin A1 (INCA1) that we previously characterized as a novel interaction partner...

  15. Les Schlumberger de l’École centrale

    OpenAIRE

    Hau, Michel; Stoskopf, Nicolas

    2010-01-01

    International audience La famille Schlumberger inaugure dès le milieu du XIXe siècle une tradition alsacienne de patrons ingénieurs dotés d’une formation scientifique et technique de haut niveau. L’itinéraire des onze Schlumberger sortis de l’Ecole centrale des arts et manufactures est ici décrit et replacé dans son contexte historique et familial.

  16. Initier au projet par le jeu. Evaluation d’une expérimentation en école d’ingénieurs

    Directory of Open Access Journals (Sweden)

    Caroline Verzat

    2009-09-01

    Full Text Available Cette communication s’appuie sur une recherche-action menée à l’automne 2006 auprès des élèves ingénieurs de l’Ecole Centrale de Lille (Bac + 3 et 4. Elle évalue l’impact d’un jeu de construction utilisant des spaghettis sur la capacité des équipes d’étudiants à émettre des idées créatives, à constituer des groupes, à gérer leurs relations au sein de ces groupes et à apprendre de leurs expériences. L’impact du jeu est mesuré par l’analyse des retours d’expérience en séance, puis par le suivi des équipes de projet réel qui démarrent ensuite. Sont examinés la composition des équipes, l’origine des sujets six semaines plus tard, puis les auto-évaluations du travail en équipe au bout de trois mois.This paper is based on an action-research, conducted with students in engineering at the Ecole Centrale de Lille in 2006. The aim of this paper is to evaluate the effects of a construction game using spaghettis on the students’ capacity to suggest creative ideas, to build and manage their team work and to learn from experience. These effects are measured through the immediate feedbacks on the game and the management of real project teams after the game. Items such as the composition of the teams, the origins of their subject six weeks later and self-evaluations of team management after 3 month are examined.

  17. Milles näete suurimat probleemi Eesti hariduselus? Mida ja kuidas võiks tulevikus teha teisiti? / Thor-Sten Vertmann, Inge Kalle, Heino Luiga, Vallo Reimaa

    Index Scriptorium Estoniae

    2007-01-01

    Küsimustele vastavad Eesti Tööandjate Keskliidu tööturunõunik Thor-Sten Vertmann, Vastse-Kuuste kooli direktor Inge Kalle, Räpina Aianduskooli direktor Heino Luiga ja regionaalminister Vallo Reimaa

  18. ING1 ist in die durch TSA induzierte Apoptose und in den FADD/Caspase-3-Signalweg in humanen Glioblastomzellen involviert

    OpenAIRE

    Tamannai, Mona

    2010-01-01

    Purpose: Prognosis for patients with glioblastoma multiforme (GBM) still remains poor. Inhibitors of histone deacetylases (HDACi) like Trichostatin A (TSA) are promising alternatives to conventional treatment. Deficient tumor suppressor functions, such as TP53 mutations and CDKN2A deletions, are characteristic for GBM and can cause resistance. We have previously reported that the type II tumor suppressor ING1 is downregulated in GBM. Problem: To test whether ING1 proteins function in TSA-...

  19. Gradients de prototypicalité, mesures de similarité et de proximité sémantique : une contribution à l'Ingénierie des Ontologies.

    OpenAIRE

    Aimé, Xavier

    2011-01-01

    En psychologie cognitive, la notion de prototype apparaît de manière centrale dans les représentations conceptuelles. Dans le cadre de nos travaux, nous proposons d'introduire cette notion au sein des activités relevant de l'Ingénierie des Ontologies et de ses modèles de représentation. L'approche sémiotique que nous avons développée est fondée sur les trois dimensions d'une conceptualisation que sont l'intension (les propriétés), l'expression (les termes), et l'extension (les instances). Ell...

  20. Adenovirus-mediated p53 and ING4 gene co-transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.

    Science.gov (United States)

    Wu, Jie; Zhu, Yanbo; Xu, Chun; Xu, Hong; Zhou, Xiumin; Yang, Jicheng; Xie, Yufeng; Tao, Min

    2016-01-01

    Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its transcriptional activity. Hence, we assumed that combined treatment of p53 and ING4 double tumor suppressors would exhibit enhanced antitumor effects. The combined therapeutic efficacy of p53 and ING4 for human cancers has not been previously reported. We thus generated multiple promoter expression cassette-based recombinant adenovirus-co-expressing ING4 and p53 double tumor suppressor genes (AdVING4/p53), evaluated the combined effects of AdVING4/p53 on breast cancer using the MDA-MB-231 (mutant p53) human breast cancer cell line, and also elucidated its underlying molecular mechanisms. We demonstrated that AdVING4/p53-mediated p53 and ING4 co-expression induced synergistic growth inhibition and apoptosis as well as enhanced effects on upregulation of acetylated p53, P21, Bax, PUMA, Noxa, cleaved caspase-9, cleaved caspase-3 and cleaved PARP, and downregulation of Bcl-2, CD31 and microvessel density (MVD) in MDA-MB-231 breast cancer in vitro and/or in vivo subcutaneous (s.c.) xenografted tumors. The synergistic antitumor activity elicited by AdVING4/p53 was closely associated with the enhanced activation of the intrinsic apoptotic pathway and synergistic inhibition of tumor angiogenesis, very possibly via ING4-mediated enhancement of p53 acetylation and activity. Thus, our results indicate that cancer gene therapy combining two or more tumor suppressors such as p53 and ING4 may constitute a novel and effective therapeutic modality for human breast cancer and other cancers. PMID:26530780

  1. Ingázás a falusi Magyarországon. Egy megoldatlan probléma

    OpenAIRE

    Kertesi, Gábor

    2000-01-01

    A tanulmány azt vizsgálja, milyen szerepet játszik a magyarországi falvakat és városokat egymással összekötő közlekedési kapcsolatok fejletlensége, illetve a közlekedés magas költsége a falusi munkanélküliség viszonylagosan magas szintjének állandósulásában. Tanulmányunk két részből áll. Az első részben egy ingázási költségeket is magában foglaló participációs modell segítségével rekonstruáljuk a városi munkavállalást fontolgató falusi lakos döntési problémáját. Ingázási modellünkből kiindulv...

  2. Sustainability Assessment of a Self-Consumption Wood-Energy Chain on Small Scale for Heat Generation in Central Italy

    OpenAIRE

    Stefano Verani; Giulio Sperandio; Rodolfo Picchio; Enrico Marchi; Corrado Costa

    2015-01-01

    The sustainability of a small-scale self-consumption wood-energy chain for heat generation in central Italy was analyzed from a technical, economic and energetic point of view. A micro-chain was developed within the CRA-ING farm at Monterotondo (Rome, Italy): The purpose of this system was to produce biomass for supplying a heating plant within the CRA-ING property as a substitute for diesel fuel. A poplar short rotation coppice, established with clones AF2, AF6 and Monviso, fed the micro-cha...

  3. Making Central Banks Serve The Real Economy

    Directory of Open Access Journals (Sweden)

    Suleika Reiners

    2013-10-01

    Full Text Available The challenge is to redirect central bank money into the real economy and to the needs of society. If new money is issued to expand the productive capacity, there is no reason for inflation. Long-term financing could become available at an affordable price. Central bank money must not replace a sound tax system and the distribution of income and wealth, but complement them. The remaining task, apart from the financing of real needs, is the prevention of speculative asset price inflation. For this, central banks and regulators should install debt brakes for the financial sector. Furthermore, independent monetary policy calls for capital account management. It enables national central banks to find space for the conduct of their own policies in an interdependent global economy. Coordination between central banks and governments might increase as policies combine monetary, fiscal and regulatory facets. The future role of central banks should particularly lie in their insights regarding capital flows and leverage cycles and in their ability to create and withdraw money, depend­ing on economic conditions.

  4. Etude des méthodes d’ingénierie de bandes par les alliages semiconducteurs et leur rôle en photovoltaïque.

    OpenAIRE

    HAMIDI, Hocine

    2015-01-01

    L’ingénierie des bandes par les alliages semiconducteurs a ouvert une boite de pandore pour les chercheurs, puisqu’il est possible avec cette technique d’atteindre n’importe quelle bande interdite en partant seulement de deux ou trois matériaux semiconducteurs purs. Le coefficient stoechiométrique de l’alliage semiconducteur s’avère être un paramètre clé dans cette ingénierie, et plusieurs applications ont pu voir le jour grâce à cette technique, surtout dans le domaine opto-électronique (las...

  5. Ingénierie des exigences et conception des systèmes d'aéronefs

    OpenAIRE

    Micouin, Patrice

    2009-01-01

    Le but de cet article est de proposer un cadre de conception des systèmes complexes aussi cohérent et complet que possible qui permette à la fois : (1) d'intégrer les activités de développement et les activités d'évaluation de la sûreté, (2) de satisfaire aux exigences émises par les autorités de certification telles que la l'EASA et FAA , (3) de répondre à des standards tels que l'ED-79/ARP 4754 [9], la ED-80/DO-254 [10], ou la ED-12/DO-178B [8], (4) de préparer la voie à une ingénierie des ...

  6. Ingénierie de l'observation basée sur la prescription en EIAH

    OpenAIRE

    Iksal, Sébastien

    2012-01-01

    Les travaux présentés correspondent à ceux que nous avons menés au sein de l'équipe IEIAH (Ingénierie des Environnements Informatiques pour l'Apprentissage Humain) au sein du Laboratoire d'Informatique de l'Université du Maine. La question de recherche générale que nous avons choisie de traiter est la suivante : "Comment aider l'enseignant/concepteur à améliorer sa situation d'apprentissage grâce à l'observation de cette dernière?". Pour cela, nous nous sommes intéressés au processus d'observ...

  7. p33ING1b和p53在银屑病和基底细胞癌中的表达及临床意义%Expressions and clinical significance of p33ING1b and p53 in psoriasis and basal cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    贺琪; 岳青; 皮先明; 石全; 陈宏翔; 李家文

    2014-01-01

    目的:探讨肿瘤抑制因子p53和生长抑制因子p33ING1b在人类银屑病和基底细胞癌(basal cell carcinoma, BCC)中的表达情况及临床意义。方法:采用免疫组织化学Envision方法检测p53和p33ING1b在36例寻常型银屑病皮损(银屑病组)、28例BCC皮损(BCC组)和14例正常表皮(正常对照组)中的蛋白表达。结果:p53在正常对照组、银屑病组和BCC组中表达递增,p33ING1b在3组中表达递减,组间比较差异均有显著性(均P<0.05)。银屑病组和BCC组中,p53与p33ING1b之间均存在显著正相关(均P<0.05)。结论:p53和p33ING1b协同作用于增生性皮肤病的局部皮损,是细胞异常增殖的重要机制之一。%Objective To discuss the expressions and clinical significance of p53 and p33ING1b in human psoriasis and basal cell carcinoma (BCC). Methods Immunohistochemistry EnVision technique was used to detect the expressions of p53 and p33ING1b in samples of 36 psoriasis vulgaris, 28 BCC and 14 normal skins. Results The expression of p53 increased while p33ING1b had a degressive expression in the control group, the psoriasis group and the BCC group. It was found significant statistical difference between the two groups (all P < 0.05). Prominent positive correlation between p53 and p33ING1b were found in both psoriasis group and BCC group (all P<0.05). Conclusions p53 coacts with p33ING1b at local lesions of abnormal proliferative diseases . It′s one of the most prominent mechanisms contributing to deviant cell proliferation.

  8. MUSE-ings on AM1354-250: Collisions, Shocks and Rings

    CERN Document Server

    Conn, Blair C; Smith, Rory; Candlish, Graeme N

    2015-01-01

    We present MUSE observations of AM1354-250, confirming its status as a collisional ring galaxy which has recently undergone an interaction, creating its distinctive shape. We analyse the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of $\\sim$70km.s$^{-1}$ and that star formation is occurring primarily in HII regions associated with the ring. This star formation activity is likely triggered by the interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated $140 \\pm 12$ Myr ...

  9. MUSE-ings on AM1354-250: Collisions, Shocks, and Rings

    Science.gov (United States)

    Conn, Blair C.; Fogarty, L. M. R.; Smith, Rory; Candlish, Graeme N.

    2016-03-01

    We present Multi Unit Spectroscopic Explorer observations of AM1354-250, confirming its status as a collisional ring galaxy that has recently undergone an interaction, creating its distinctive shape. We analyze the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of ˜70 km s-1 and that star formation is occurring primarily in H ii regions associated with the ring. This star formation activity is likely triggered by this interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains a weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated 140 ± 12 Myr ago.

  10. OGLE-ing the Magellanic system: stellar populations in the Magellanic Bridge

    International Nuclear Information System (INIS)

    We report the discovery of a young stellar bridge that forms a continuous connection between the Magellanic Clouds. This finding is based on number density maps for stellar populations found in data gathered by OGLE-IV that fully cover over 270 deg2 of the sky in the Magellanic Bridge area. This is the most extensive optical survey of this region to date. We find that the young population is present mainly in the western half of the MBR, which, together with the newly discovered young population in the eastern Bridge, form a continuous stream of stars connecting both galaxies along δ ∼ –73.5 deg. The young population distribution is clumped, with one of the major densities close to the SMC and the other fairly isolated and located approximately mid-way between the Clouds, which we call the OGLE island. These overdensities are well matched by H I surface density contours, although the newly found young population in the eastern Bridge is offset by ∼2 deg north from the highest H I density contour. We observe a continuity of red clump stars between the Magellanic Clouds which represent an intermediate-age population. Red clump stars are present mainly in the southern and central parts of the Magellanic Bridge, below its gaseous part, and their presence is reflected by a strong deviation from the radial density profiles of the two galaxies. This may indicate either a tidal stream of stars, or that the stellar halos of the two galaxies overlap. On the other hand, we do not observe such an overlap within an intermediate-age population represented by the top of the red giant branch and the asymptotic giant branch stars. We also see only minor mixing of the old populations of the Clouds in the southern part of the Bridge, represented by the lowest part of the red giant branch.

  11. OGLE-ing the Magellanic system: stellar populations in the Magellanic Bridge

    Energy Technology Data Exchange (ETDEWEB)

    Skowron, D. M.; Jacyszyn, A. M.; Udalski, A.; Szymański, M. K.; Skowron, J.; Poleski, R.; Kozłowski, S.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Mróz, P.; Pietrukowicz, P.; Ulaczyk, K.; Wyrzykowski, Ł., E-mail: dszczyg@astrouw.edu.pl [Warsaw University Astronomical Observatory, Aleje Ujazdowskie 4, 00-478 Warszawa (Poland)

    2014-11-10

    We report the discovery of a young stellar bridge that forms a continuous connection between the Magellanic Clouds. This finding is based on number density maps for stellar populations found in data gathered by OGLE-IV that fully cover over 270 deg{sup 2} of the sky in the Magellanic Bridge area. This is the most extensive optical survey of this region to date. We find that the young population is present mainly in the western half of the MBR, which, together with the newly discovered young population in the eastern Bridge, form a continuous stream of stars connecting both galaxies along δ ∼ –73.5 deg. The young population distribution is clumped, with one of the major densities close to the SMC and the other fairly isolated and located approximately mid-way between the Clouds, which we call the OGLE island. These overdensities are well matched by H I surface density contours, although the newly found young population in the eastern Bridge is offset by ∼2 deg north from the highest H I density contour. We observe a continuity of red clump stars between the Magellanic Clouds which represent an intermediate-age population. Red clump stars are present mainly in the southern and central parts of the Magellanic Bridge, below its gaseous part, and their presence is reflected by a strong deviation from the radial density profiles of the two galaxies. This may indicate either a tidal stream of stars, or that the stellar halos of the two galaxies overlap. On the other hand, we do not observe such an overlap within an intermediate-age population represented by the top of the red giant branch and the asymptotic giant branch stars. We also see only minor mixing of the old populations of the Clouds in the southern part of the Bridge, represented by the lowest part of the red giant branch.

  12. Problems and Countermeasures of Colloquial English Large Size Class Teach-ing of Higher Vocational Public English under the Constructivism Theory

    Institute of Scientific and Technical Information of China (English)

    WANG Yan-ping

    2014-01-01

    Based on the theory of constructivism, this article analyzes the open problems colloquial English large size class teach-ing of higher vocational public English and points out the countermeasures of colloquial English large-scale class teaching of high-er vocational public English.

  13. Warm isostatic pressing (WIP'ing) of GS44 Si{sub 3}N{sub 4} FDC parts for defect removal

    Energy Technology Data Exchange (ETDEWEB)

    Wu Suxing; Rangarajan, Sriram; Dai Cheng; McCuiston, Ryan; Langrana, Noshir A.; Safari, Ahmad; Danforth, Stephen C.; Clancy, Richard B.; Whalen, Philip J

    2003-12-15

    Fused deposition of ceramics (FDC) is one of the developing solid freeform fabrication (SFF) techniques. The successful production of high performance ceramics by the FDC process requires that no defects exist in the green parts. However, build defects, such as missing roads, poorly bonded layers or sub-perimeter voids can be encountered in improperly built FDC parts. In this study, a method known as WIP'ing (warm isostatic pressing) was evaluated for its ability to eliminate existing defects in GS44 Si{sub 3}N{sub 4} green FDC parts. Analogous to CIP'ing (cold isostatic pressing), the green FDC parts were rubber bagged and loaded into a pressure chamber filled with water soluble oil at different temperatures, ranging from 30 to 90 deg. C, at pressures of up to 35 MPa. X-Ray radiography results indicated that at temperatures above 70 deg. C, WIP'ing was effective in closing the gaps of the intentionally placed void defects in FDC parts. However, WIP'ing above 70 deg. C was not effective in healing the defects completely. The fracture strengths of FDC parts with intentional added defects, WIP'ed above 70 deg. C were substantially lower than control samples.

  14. Material development in the SI sub 3 N sub 4 system using glass encapsulated Hip'ing

    Energy Technology Data Exchange (ETDEWEB)

    Corbin, N.D.; Sundberg, G.J.; Siebein, K.N.; Willkens, C.A.; Pujari, V.K.; Rossi, G.A.; Hansen, J.S.; Chang, C.L.; Hammarstrom, J.L.

    1992-04-01

    This report covers a two-year program to develop fully dense Si{sub 3}N{sub 4} matrix SiC whisker composites with enhanced properties over monolithic Si{sub 3}N{sub 4} materials. The primary goal was to develop a composite with a fracture toughness > 10 MPa{radical}m, capable of using high pressure glass encapsulated HIP'ing. Coating methods were developed to apply thin (<150nm) stoichiometric BN layers to SiC whiskers and also to apply a dual coating of SiC over carbon to the whiskers. Fracture toughness of the composites was determined to increase as the quantity of whiskers (or elongated grains) with their axis perpendicular to the crack plane increased. Of the interface compositions evaluated in this effort, carbon was determined to be the most effective for increasing toughness. The highest toughnesses (6.8--7.0 MPa{radical}m) were obtained with uniaxially aligned carbon coated whiskers. There was no evidence of the carbon coating compromising the oxidation resistance of the composites at 1370{degree}C.

  15. L’ingénierie des systèmes appliqués à l’autoroute est-ouest

    OpenAIRE

    KERBOUA, Mohammed

    2012-01-01

    Ce document est un outil pour les gestionnaires de transports en Algérie d’une manière générale et du transport routier d’une manière spécifique désireux de réfléchir à leur approche de management ingénierie et à la manière de gérer leur démarche d’intégration des technologies de l’information des communications (TIC) et du management de l’ingénierie de système. Il vise à sensibiliser les membres de la direction de transport à une approche systémique fondée sur un leadership pa...

  16. Approche pragmatique de conception d'un EIAH : réingénierie pédagogique dirigée par les modèles

    OpenAIRE

    El-Kechaï, Hassina; Choquet, Christophe

    2005-01-01

    L'objectif de cet article est de proposer une démarche de conception participative entre chercheurs et enseignants et de montrer, à l'éclairage de la mise à l'essai d'un dispositif d'apprentissage collaboratif, comment elle se réifie dans un contexte situé. En particulier, nous présentons comment le processus d'ingénierie et de réingénierie guidé par le modèle de conception du scénario pédagogique permet aux enseignants de s'approprier, de concevoir et d'intégrer dans leurs pratiques pédagogi...

  17. Les ingénieurs de l'Institut algérien du pétrole : formation et parcours professionnels

    OpenAIRE

    Ali Benali, Azzedine

    2014-01-01

    La politique d'industrialisation entreprise en Algérie dans les décennies 1960-1970 a permis à plusieurs générations de cadres, en particulier celles de l'après indépendance, de voir leur carrière progresser rapidement et d'accéder aux plus hautes fonctions de responsabilité. L'Etat mobilisait alors des moyens techniques et financiers considérables pour la formation des ingénieurs et des techniciens, afin de garantir l'indépendance technique du pays. Aussi peut-on avancer l'idée que les ingén...

  18. Kartlegging av organisasjonskultur ved Lyngdal ungdomsskole ; kartlegging av organisasjonskultur med OCAI ett år etter sammenslåing av to likestilte organisasjoner

    OpenAIRE

    Moe, Marith Johanne

    2014-01-01

    Kartlegging av organisasjonskultur er i liten utstrekning i dag benyttet som et verktøy for ledelse i offentlig sektor. Denne oppgaven tar for seg kartlegging av organisasjonskulturen ved en ungdomskole ett år etter sammenslåing av to likestilte organisasjoner, to tidligere ungdomskoler. Cameron og Quinns (2013) metode Organzational Cultural Assessment Instrument (OCAI), er benyttet i kartleggingen. Kartleggingen inngikk i et større prosjekt ved Universitetet i Agder (UIA) hvor en kartla ...

  19. Dinâmica do chumbo no lago do parque Ingá, Maringá, PR, Brasil

    Directory of Open Access Journals (Sweden)

    Sérgio Renato Vaz

    1998-08-01

    Full Text Available Este trabalho analisa a dinâmica do chumbo no lago do parque do Ingá, Maringá - PR. Mensalmente durante um ano foram coletadas amostras de água e sedimentos e o pH e temperatura medidos no ato da coleta. Nas amostras de água foi determinada a Demanda Química de Oxigênio (DQO e a concentração total de Pb na água e sedimentos. A determinação da concentração Pb na água e sedimentos foi feita com a técnica da espectrometria da absorção atômica, modalidade chama. Os valores médios mensais encontrados, em intervalos e médias globais foram respectivamente: concentração de Pb na água, em ng.mL-1, não detectado (nd - 55,56 e 19,23; Pb em sedimentos, em µg.g-1, 48,73 - 92,87 e 71,93; pH, 7,02 - 8,23 e 7,60; temperatura, em °C, 19,33 - 27,48 e 23,73; DQO, em mg.L-1, 13,33 - 30,11 e 23,54. Uma análise dos resultados das variáveis medidas, em nível de 5% de significância permitem concluir que a concentração de Pb na água é independente dos pontos de coleta (local, mas, dependente do período de amostragem (temporalidade e nos sedimentos dependente dos dois parâmetros.This work introduce the study of lead dynamic in the lake of Ingá Park, Maringá - PR. Monthly, during a year, samples of water and sediments were collected and pH and temperature measured. In the water samples were determined the chemical oxygen demand (COD and the total lead concentration in water and sediment samples. The determination of lead concentration in water and sediments was performed with atomic absorption spectrometer - flame technique. The monthly mean values found, presented in intervals and global mean values, were respectively: lead concentration in water (ng.mL-1, non detected (nd - 55.56 and 19.23; lead in sediments (µg.g-1, 48.73 - 92.87 and 71.93; pH, 7.02 - 8.23 and 7.60; temperature (ºC, 19.33 - 27.48 and 23.73; COD (mg.L-1, 13.33 - 30.11 and 23.54. A survey of the lead concentration results found permit to conclude, at 5% of

  20. Muutunud Euroopa / Inge Pitsner

    Index Scriptorium Estoniae

    Pitsner, Inge

    2009-01-01

    Mihhail Vladislavlev ja Aleksandr Zukerman kordasid 15 aasta tagust reisi taksoga mööda Euroopat. Sellest, mis on muutunud Poolas, Horvaatias, Essenis, Linzis ja Eestis "Subboteja" tegijate omil sõnul

  1. Europa central

    Directory of Open Access Journals (Sweden)

    Karel BARTOSEK

    2010-02-01

    Full Text Available La investigación francesa continúa interesándose por Europa Central. Desde luego, hay límites a este interés en el ambiente general de mi nueva patria: en la ignorancia, producto del largo desinterés de Francia por este espacio después de la Segunda Guerra Mundial, y en el comportamiento y la reflexión de la clase política y de los medios de comunicación (una anécdota para ilustrar este ambiente: durante la preparación de nuestro coloquio «Refugiados e inmigrantes de Europa Central en el movimiento antifascista y la Resistencia en Francia, 1933-1945», celebrado en París en octubre de 1986, el problema de la definición fue planteado concreta y «prácticamente». ¡Y hubo entonces un historiador eminente, para quién Alemania no formaría parte de Europa Central!.

  2. Finance computationnelle et gestion des risques ingénierie financière avec applications Excel (Visual Basic) et Matlab

    CERN Document Server

    Racicot, François-Éric

    2006-01-01

    Ce manuel propose un exposé rigoureux de la gestion des risques en finance. Les aspects théoriques de la question sont abordés par des démonstrations claires et des rappels élaborés des bases mathématiques de la finance computationnelle. Le texte est émaillé de nombreux programmes écrits en langages Visual Basic (Excel), Matlab et EViews qui prépareront l'étudiant à sa carrière de spécialiste en ingénierie financière.

  3. Ré-ingénierie d'une plate-forme fondée sur la modélisation d'un processus global de FOAD

    OpenAIRE

    Oubahssi, Lahcen; Grandbastien, Monique; Claës, Gérard

    2004-01-01

    Les fournisseurs de plates-formes pour la formation en ligne doivent pouvoir adapter leur offre aux nouveaux besoins des acteurs et aux évolutions technologiques tout en exploitant un existant. Un processus de réingénierie de logiciel existant, aboutissant à une architecture à base de composants réutilisables et interopérables est proposé dans cet article. Il comprend une spécification fonctionnelle couvrant l'ensemble du cycle d'une FOAD et une décomposition en composants implantant les fonc...

  4. The hydrology of Lake Rousseau, west-central Florida

    Science.gov (United States)

    German, E.R.

    1978-01-01

    Lake Rousseau, about 4 miles southwest of Inglis, Florida, was formed in 1909 by impoundment of the Withlacooche River by Inglis Dam, west of Dunnellon, Florida. The lake was to have been part of the Cross-Florida Barge Canal; a lock and channel associated with the presently inactive project were completed in 1969. Lake Rousseau is about 11 miles long, covers about 4,000 acres, and contains about 34,000 acre-feet of water at the normal pool elevation of 27.5 feet above mean sea level. Inflow to the lake is relatively constant and responds slowly to rainfall. The estimated 100-year peak inflow, 10,400 cubic feet per second, is only 19 percent higher than the 100-year high monthly inflow. Water in Lake Rousseau is a calcium-bicarbonate type and is hard. Mean total phosphorus and organic nitrogen concentrations are considerably lower in Lake Rousseau than in north-central Florida lakes which have been considered to be eutrophic by other investigators, however, the lake supports of prolific aquatic plant community. Dissolved-oxygen concentrations near the water surface are occasionally less than 3 mg/liter. (Woodard-USGS)

  5. Production de savoir et dynamique pédagogique ingénieuse. Le cas particulier de « l’Ecole de Tours »

    Directory of Open Access Journals (Sweden)

    Catherine Guillaumin

    2012-04-01

    Full Text Available Depuis les années ‘80, les enseignants-chercheurs du département des sciences de l’éducation et de la formation de l’Université de Tours développent une pédagogie universitaire de formation par alternance comme voie différente pour apprendre et se former. « L’Ecole de Tours » est fondée sur le primat de l’expérience et celui de la production de savoir, renversant l’ordonnancement classique de la formation, mais convergeant vers l’abstraction avec les mêmes exigences de savoirs rigoureux conceptuels et méthodologiques. Elle est le produit complexe de l’ingenium lerbétien et du génie stratégique et pédagogique de Gaston Pineau. Cette contribution recense et explicite l’ingéniosité pédagogique qui structure transversalement ces dispositifs de formation associant, dans la complémentarité, les professionnels, dans et hors les murs de l’université, tandis qu’une veille réflexive et transformatrice, attentive aux changements sociétaux, oriente les ré-ingénieries successives.

  6. Model(ing) Law: The ICTY, the International Criminal Justice Template, and Reconciliation in the Former Yugoslavia

    DEFF Research Database (Denmark)

    Carlson, Kerstin Bree

    2013-01-01

    term the international criminal justice template. This template accords three transitional justice functions for ICTs beyond (and in conjunction with) their central judicial aim of adjudicating cases: as (1) articulators of progressive criminal law (2) historians and (3) reconcilers or storytellers. My...... development of international law and society studies, in order to better theorize and understand the structural and theoretical constraints governing the establishment of legitimacy for international criminal courts.......My project uses the case study of the ICTY and reconciliation in the Balkans to address the larger topic of the capacity of international criminal tribunals (ICTs) as transitional justice mechanisms. I argue that the ICTY operates under the (flawed) received wisdom of the IMT at Nuremberg, what I...

  7. Gérer l'interface entre ingénierie, didactique, pédagogie et dispositifs ouverts Interfacing open learning environments, didactics and pedagogy

    OpenAIRE

    Guy Achard-Bayle; Françoise Demaizière

    2003-01-01

    Nous proposons de croiser le regard du didacticien linguiste et celui du spécialiste de l'utilisation des TIC pour la formation et de l'ingénierie de formation, afin d'analyser des dispositifs expérimentaux "ouverts" que nous avons pu observer de près. Le premier est un dispositif à distance basé sur une pédagogie du projet, le second relève de l'autoformation guidée en centre de ressources. Dans les deux cas on relève le rôle pivot du centre de ressources et la disparition du groupe-...

  8. Dispositifs d'apprentissage instrumentés par les technologies : vers une ingénierie centrée sur les scénarios

    OpenAIRE

    Pernin, Jean-Philippe; Lejeune, Anne

    2004-01-01

    Les récents travaux qui centrent leur démarche sur l'activité et sur les langages de modélisation pédagogique amènent à étudier la notion de scénario pédagogique, terme souvent employé mais répondant à des définitions variées. L'objet de cet article est de poser les bases d'une nouvelle approche d'ingénierie des dispositifs instrumentés fondée sur les scénarios. Nous proposons un modèle conceptuel reposant sur un vocabulaire précis et sur une taxonomie des scénarios, en nous intéressant parti...

  9. Discerner, éviter ou ingérer le trouble L'aliment comme enjeu sanitaire, individuel et collectif : (exemples africains au regard du contemporain)

    OpenAIRE

    Bargès, Anne

    2005-01-01

    Le propos se fera sur la base d'un travail sur la maladie grave et chronique en Afrique de l'Ouest associé à des réflexions actuelles sur les besoins de l'individu et de la société en matière de prédiction du mal et de prévention de la santé. Sous l'angle de la chose ingérée, de sa comestibilité, seront abordées les représentations causales d'une méta-maladie, la lèpre, se partageant entre deux paradigmes (le mal germant dans la personne et le mal déposé sur la personne, l'intérieur et l'exté...

  10. Cambodian and their Doctors, a Medical Anthropology of Colonial and Post-Colonial Cambodia, Jan Ovesen & Ing-Britt Trankell

    Directory of Open Access Journals (Sweden)

    Didier Bertrand

    2012-09-01

    Full Text Available Cet ouvrage, écrit par Jan Ovesen et Ing-Britt Trankell (professeurs associés d’anthropologie à l’université d’Uppsala engagés dans l’étude de la société cambodgienne depuis 1995, offre une synthèse unique d’anthropologie historique et d’ethnographie contemporaine sur le système de soins de santé cambodgien de la colonisation française à nos jours. Les auteurs décrivent la tension dans le Cambodge moderne entre la tradition médicale occidentale introduite par les colonisateurs français et le...

  11. Central Pain Syndrome

    Science.gov (United States)

    ... Enhancing Diversity Find People About NINDS NINDS Central Pain Syndrome Information Page Table of Contents (click to ... being done? Clinical Trials Organizations What is Central Pain Syndrome? Central pain syndrome is a neurological condition ...

  12. L'ingénierie lexicale ou la description d'un objet entre l'invention et la découverte

    Directory of Open Access Journals (Sweden)

    Jean-Nicolas De Surmont

    2011-10-01

    Full Text Available

    RÉSUMÉ: Résoudre des problèmes théoriques constitue également résoudre des problèmes lexicaux. C'est ce que nous avons baptisé l'ingénierie lexicale, processus d'évaluation et de description d'une activité ou d'une discipline et de création de termes ou de lexies pouvant satisfaire les besoins théoriques du chercheur. La nécessité de recourir à l'ingénierie lexicale peut apparaître dans différents contextes scientifiques notamment les études transdisciplinaires, les études diachroniques, l'harmonisation interlinguistique, etc. Nous présentons donc différents cas de figures notamment dans le cadre de nos travaux sur la poésie vocale.

    Mots-clés: INGE⁄NIERIE LEXICALE, RE⁄SOLUTION DE PROBLEŸME (LEXIQUE, LEXICOLOGIE, TERMINOLOGIE, E⁄PISTE⁄MOLOGIE

    ABSTRACT: Lexical Engineering or the Description of an Object between Invention and Discovery. Solving theoretical problems also involves solving lexical problems. This we have named lexical engineering, a process of evaluation and description of an activity or a discipline and the creation of terms or lexical items, which have to satisfy the theoretical needs of the researcher. The necessity to resort to lexical engineering becomes apparent in different scientific contexts, notably transdisciplinary studies, diachronic studies, interlinguistic harmonization, etc. We therefore present different kinds of figurative senses notably as part of our work on vocal poetry.

     

  13. Gérer l'interface entre ingénierie, didactique, pédagogie et dispositifs ouverts Interfacing open learning environments, didactics and pedagogy

    Directory of Open Access Journals (Sweden)

    Guy Achard-Bayle

    2003-06-01

    Full Text Available Nous proposons de croiser le regard du didacticien linguiste et celui du spécialiste de l'utilisation des TIC pour la formation et de l'ingénierie de formation, afin d'analyser des dispositifs expérimentaux "ouverts" que nous avons pu observer de près. Le premier est un dispositif à distance basé sur une pédagogie du projet, le second relève de l'autoformation guidée en centre de ressources. Dans les deux cas on relève le rôle pivot du centre de ressources et la disparition du groupe-classe. Quelques points importants pour une approche des dispositifs ouverts se dégagent, entre autres tutorat et suivi des apprenants, rapport au temps (temps perdu, temps retrouvé, choix des ressources supports des apprentissages (outils de référence et matériaux pédagogiques. Nous plaiderons pour une meilleure gestion de l'interface entre ingénierie, didactique, pédagogie et dispositifs ouverts par une remobilisation du didacticien autour de quelques axes se dégageant de nos observations.We acted as linguists interested in didactics and specialists in the use of ICT to analyze two language learning environments we had an opportunity to closely follow. Both can be labeled as open learning systems relying on self directed learning. We point out the importance of the self access learning centre where learners come and the disappearance of the traditional group. Several relevant elements are analyzed such as tutoring and coaching of learners, changes in the relationship to time (wasting and finding time, choosing appropriate materials (reference tools or teaching materials. We will argue in favor of a more deliberate implication of didactics so as to better approach open learning situations and self directed learning.

  14. Banco Central de Costa Rica

    Directory of Open Access Journals (Sweden)

    Sauter, Franz

    1963-06-01

    Full Text Available This new building is intended to house the various services of the Central Bank of Costa Rica. It has a prestressed concrete structure, and consists of a basement parking space for 105 vehicles, and nine storeys, providing altogether a floor surface of 12,000 ms2. The building rests on a ground area of 40 by 60 ms, and the main structure occupies 22 by 45 ms. This Bank is located in a district of narrow streets, but its main side overlooks a green open space, which will improve its visibility and appearance. The building structure is made up of a framework of prestressed beams and columns. The beams have been concreted at the site, and the joists, which are also prestressed, are factory made. This framework, at each floor level, constitutes the basis of a continuous slab, which renders the total structure exceedingly stiff. The main continuous girders span 11.22 ms spaces, and vary in cross section. The prestressing reinforcements consist of 6 Loeba type cables. This is an original design by Dr. Leonhardt, in which the cables are placed on three horizontal layers, of parabolic outline. Each cable is made up of 12 x 5.4 mm wires, with a breaking stress of 180 kg/mm2 The tensioning stress was 108 kg/mm2, and the total prestress load is 29,700 kgs. The cables run in corrugated metal tubes, and these were kept in precise position with the aid of distance pieces.El nuevo edificio, destinado a agrupar los servicios del Banco Central de Costa Rica, está constituido por una estructura de hormigón pretensado. El inmueble dispone de un sótano, estacionamiento propio para 105 vehículos y nueve plantas, con una superficie total de 12.000 metros cuadrados. Se asienta sobre una base de 40x60 m, donde se levanta un núcleo central de 22x45 metros. Está situado en un barrio de calles estrechas, pero tiene su fachada, principal frente a una zona verde que le proporcionará mayor categoría y visibilidad. La estructura se compone de una retícula de vigas

  15. To centralize or not to centralize?

    OpenAIRE

    Campbell, Andrew; Kunisch, Sven; Müller-Stewens, Günter

    2011-01-01

    The CEO's dilemma-were the gains of centralization worth the pain it could cause?-is a perennial one. Business leaders dating back at least to Alfred Sloan, who laid out GM's influential philosophy of decentralization in a series of memos during the 1920s, have recognized that badly judged centralization can stifle initiative, constrain the ability to tailor products and services locally, and burden business divisions with high costs and poor service.1 Insufficient centralization can deny bus...

  16. Straumur í æðum. Rafvæðing Íslands með tilliti til verka sjálfmenntaðra manna

    OpenAIRE

    Tinna Guðbjartsdóttir 1983

    2014-01-01

    Í þessari ritgerð er farið yfir rafvæðingu Íslands. Skoðað er hvernig rafvæðingin hefst og hversu langan tíma hún tók. Byrjað er á að skoða hvernig þekking á rafmagni þróast frá Forn-Grikklandi til 19. aldar. Einnig er skoðað hvernig rafvæðing fer fram í Bandaríkjunum með áherslu á vinnu Thomas Edisons, Nikola Tesla og George Westinghouse. Farið er yfir sögu rafvæðingar á Íslandi frá komu Frímanns Arngrímssonar til landsins og þar til rafveitur fara að hasla sér völl. Skoðaðar eru ástæður ...

  17. Velferð raflausnarbíla hjá Alcoa Fjarðaráli : innleiðing og ávinningur

    OpenAIRE

    Þórður Valdimarsson 1965

    2015-01-01

    Í þessu verkefni er leitast við að svara því hver er ávinningur af innleiðingu á velferð búnaðar fyrir raflausnarbíla Fjarðaáls og með hvaða hætti væri skynsam-legt að innleiða þessa aðferðafræði. Lögð var fyrir spurningakönnun sem starfs-fólk kerskála svaraði. Með því fengust mikilvæg gögn sem koma til með að móta hvernig verði staðið að innleiðingu á velferð búnaðar. Velferð búnaðar er þýðing Alcoa á autonomous maintenance. Í bók Iðntæknistofnunar TPM fyrir starfsfólk í iðnaði er íslensk þ...

  18. Central Neuropathic Pain Syndromes.

    Science.gov (United States)

    Watson, James C; Sandroni, Paola

    2016-03-01

    Chronic pain is common in patients with neurologic complications of a central nervous system insult such as stroke. The pain is most commonly musculoskeletal or related to obligatory overuse of neurologically unaffected limbs. However, neuropathic pain can result directly from the central nervous system injury. Impaired sensory discrimination can make it challenging to differentiate central neuropathic pain from other pain types or spasticity. Central neuropathic pain may also begin months to years after the injury, further obscuring recognition of its association with a past neurologic injury. This review focuses on unique clinical features that help distinguish central neuropathic pain. The most common clinical central pain syndromes-central poststroke pain, multiple sclerosis-related pain, and spinal cord injury-related pain-are reviewed in detail. Recent progress in understanding of the pathogenesis of central neuropathic pain is reviewed, and pharmacological, surgical, and neuromodulatory treatments of this notoriously difficult to treat pain syndrome are discussed. PMID:26944242

  19. NIDDK Central Repository

    Data.gov (United States)

    U.S. Department of Health & Human Services — The NIDDK Central Repository stores biosamples, genetic and other data collected in designated NIDDK-funded clinical studies. The purpose of the NIDDK Central...

  20. Central and peripheral demyelination

    OpenAIRE

    Man Mohan Mehndiratta; Natasha Singh Gulati

    2014-01-01

    Several conditions cause damage to the inherently normal myelin of central nervous system, perepheral nervous system or both central and perepheral nervous system and hence termed as central demyelinating diseases, perepheral demyelinating diseases and combined central and perepheral demyelinating diseases respectively. Here we analysed and foccused on the etiology, prevalance, incidence and age of these demyelinating disorders. Clinical attention and various diagnostic tests are needed to ad...

  1. Analyse d'incertitudes et aide à la décision : contributions méthodologiques, techniques et managériales aux études d'ingénierie et de R&D

    OpenAIRE

    Pasanisi, Alberto

    2014-01-01

    Le message principal livré par ce manuscrit, qui constitue également le fil conducteur des activités techniques et scientifiques que nous présentons ici, est que les méthodes mathématiques avancées, en particulier issues du domaine des probabilités et de la statistique sont nécessaires pour la résolution de problèmes d'ingénierie. Ces méthodes, pas toujours familières aux ingénieurs, deviennent de plus en plus indispensables dans la pratique industrielle. Le but de ce document est aussi de ré...

  2. Complete genome sequence of Peptoniphilus sp. strain ING2-D1G isolated from a mesophilic lab-scale completely stirred tank reactor utilizing maize silage in co-digestion with pig and cattle manure for biomethanation.

    Science.gov (United States)

    Tomazetto, Geizecler; Hahnke, Sarah; Maus, Irena; Wibberg, Daniel; Pühler, Alfred; Schlüter, Andreas; Klocke, Michael

    2014-12-20

    The bacterium Peptoniphilus sp. strain ING2-D1G (DSM 28672), a mesophilic and obligate anaerobic bacterium belonging to the order Clostridiales was isolated from a biogas-producing lab-scale completely stirred tank reactor (CSTR) optimized for anaerobic digestion of maize silage in co-fermentation with pig and cattle manure. In this study, the whole genome sequence of Peptoniphilus sp. strain ING2-D1G, a new isolate potentially involved in protein breakdown and acidogenesis during biomass degradation, is reported. The chromosome of this strain is 1.6Mb in size and encodes genes predicted to be involved in the production of acetate, lactate and butyrate specifying the acidogenic metabolism of the isolate. PMID:25242663

  3. Conception Collective de scénarios pédagogiques dans un contexte de réingénierie : une approche par la métamodélisation située

    OpenAIRE

    El-Kechai, Hassina

    2008-01-01

    Mon sujet de thèse s'inscrit dans le contexte de l'ingénierie des Environnements Informatiques pour l'Apprentissage Humain (EIAH) et porte sur la mise en oeuvre d'un processus dédié à la conception collective de scénarios pédagogiques dans un contexte de réingénierie.Ce processus doit pouvoir aider des équipes de conception dont le but est de décrire des situations d'apprentissage qui peuvent être opérationnalisées dans un Environnement Informatique pour l'Apprentissage Humain (EIAH).Nous con...

  4. Redescription of some Spauligodon spp. and Parapharyngodon spp., and of skrjabinodon mabuyae (Sandground, 1936) inglis, 1968 (Pharyngodonidae: Oxyuroidea) from insectivorous South African lizards.

    Science.gov (United States)

    Hering-Hagenbeck, S F B N; Petter, A J; Boomker, J

    2002-03-01

    As part of a study on the helminth parasites of South African lizards several species of saurians were collected from localities in the North West Province, the Northern Province, Mpumalanga Province and Gauteng Province. Spauligodon blydeensis (Hering-Hagenbeck, 2001) from the Cape thick-toed gecko, Pachydactylus capensis, Spauligodon molpoensis (Hering-Hagenbeck, 2001) from Wahlberg's velvet gecko, Homopholis wahibergii, Parapharyngodon margaritiferi, Hering-Hagenbeck, 2001 from the skink, Mabuya margaritifer, Parapharyngodon gerrhosauri, Hering-Hagenbeck, 2001 from the plated lizard, Gerrhosaurus flavigularis and Skrjabinodon mabuyae (Sandground, 1936) Inglis, 1968 from the skinks Mabuya punctatissima, Mabuya spilogaster and Mabuya varia are redescribed. The different Spauligodon spp. in the subcontnent may be separated on the presence or absence of spicules in the males, the presence or absence of spines on the tail of both the males and females, as well as on the size and shape of the eggs, and the configuration of the polar caps. The Parapharyngodon spp. are distinguished mainly by the morphological characters of the males, such as the width of the caudal alae and the size of the pre- and adanal papillae. Female Parapharyngodon spp. closely resemble each other and some could not be identified to the species level since males were absent. Spinose larvae, together with adult Parapharyngodon spp. were recovered from Mabuya margaritifer. All Parapharyngodon spp. larvae described to date are spinose and since the larvae in this study were collected together with adult Parapharyngodon spp., we consider them to belong to the same genus. Skrjabinodon mabuyae differs from the closely related Skrjabinodon mabuiensis in the presence of a spicule in the male and lateral alae in the female. The former nematode is described for the first time from skinks in South Africa. PMID:12092780

  5. A Study of the Central Auditory Function in Stutters by Masking Level Difference and Synthetic Sentence Identification Tests

    Directory of Open Access Journals (Sweden)

    Afsaneh Rajab

    2007-06-01

    Full Text Available Background and Aim: There are evidences that indicate a relationship between auditory processing disor¬ders and stuttering,¬ and any disorder in the central auditory function can be at least one of the underly¬ing causes of stuttering. Even though, using the most state of the art radiographic technologies, i.e. MRI, no definitive answer has been given in relative to this question. In this research, using Mask-ing Level Difference (MLD and Synthetic Sentence Identification (SSI tests, the central auditory func¬tion of stutters and normal group was evaluated.Materials and Methods: In this study was analytic cross-sectional, fifteen male patients with stutter-ing and 15 male normal cases with the age range from 16 to 40 years (average age 26.78 year were evalu¬ated. SSI-ICM, SSI-CCM and MLD tests were performed. The results were compared in both groups.Results: Although stutterers mean MLD was less than that of normal group, the different was not signifi¬cant between stutters and normal group in SSI test in right ear at negative MCRs. There was a signifi¬cant difference in ICM state, but in CCM state, there was no significant difference between the aver¬age score of two groups in various MCRs.Conclusion: The findings of this research is compatible with those of similar researches about the SSI test and the pattern of results, probably indicates a partial dysfunction of brainstem in some of the stutters.

  6. CENTRAL ASIA'S POWER DILEMMAS

    OpenAIRE

    Budkin, Viktor

    2006-01-01

    It turned out to be much harder to create new power structures in Central Asia than elsewhere in the post-socialist world: no matter how hard it was for the Central European countries to acquire new political institutions, their advance toward the Western democratic model was much smoother. In the European part of the post-Soviet geopolitical expanse, Russia, Ukraine, and Moldova experienced fewer problems than the Central Asian region (CAR for short), though they too had their share of contr...

  7. Central Laboratories Services

    Data.gov (United States)

    Federal Laboratory Consortium — The TVA Central Laboratories Services is a comprehensive technical support center, offering you a complete range of scientific, engineering, and technical services....

  8. Traits associated with winter wheat grain yield in Central and West Asia

    Institute of Scientific and Technical Information of China (English)

    Marta Silva Lopes; Didem Saglam; Mutlu Ozdogan; Matthew Reynolds

    2014-01-01

    Improved adaptation of winter wheat (Triticum aestivum L.) to drought and heat may be influenced by days to heading, plant height, biomass, canopy temperature (CT) at grain fil ing, and rate of senescence. This study shows that, under supplemental irrigation or rainfed conditions, days to heading and plant height together explain up to 68%of grain yield (GY) variation, and these associations were further confirmed in several locations across West and Central Asia. Days to heading can be slightly reduced below that of check line Karahan to further improve GY while avoiding the effect of late frosts. Plant height has been decreased in recent germplasm, but further reductions below that of check line Karahan could stil improve GY in a wide range of environ-ments. However, in Iranian sites, tal er genotypes showed better adaptation with higher biomass and increased reserves for grain fil ing. Canopy temperature and rate senescence were not associated with GY. A normalized difference vegetation index, used to estimate biomass (Feekes stages 4-5), had intermediate heritability across environments and correlated positively with GY under low plant density and should be explored further as a tool for early selection.

  9. Central centrifugal cicatricial alopecia

    OpenAIRE

    Collin Blattner; Dennis C Polley; Frank Ferritto; Elston, Dirk M

    2013-01-01

    Central centrifugal cicatricial alopecia is a common cause of progressive permanent apical alopecia. This unique form of alopecia includes entities previously know as “hot comb alopecia,” “follicular degeneration syndrome,” “pseudopelade” in African Americans and “central elliptical pseudopelade” in Caucasians. The etiology appears to be multifactorial and the condition occurs in all races.

  10. Central pontine myelinolysis

    Science.gov (United States)

    ... from one nerve to another. The most common cause of central pontine myelinolysis is a quick change in the body's sodium ... The nerve damage caused by central pontine myelinolysis is usually ... The disorder can cause serious long-term (chronic) disability.

  11. Central Diffraction at ALICE

    CERN Document Server

    Lämsä, Jerry W

    2011-01-01

    The ALICE experiment is shown to be well suited for studies of exclusive final states from central diffractive reactions. The gluon-rich environment of the central system allows detailed QCD studies and searches for exotic meson states, such as glueballs, hybrids and new charmonium-like states. It would also provide a good testing ground for detailed studies of heavy quarkonia. Due to its central barrel performance, ALICE can accurately measure the low-mass central systems with good purity. The efficiency of the Forward Multiplicity Detector (FMD) and the Forward Shower Counter (FSC) system for detecting rapidity gaps is shown to be adequate for the proposed studies. With this detector arrangement, valuable new data can be obtained by tagging central diffractive processes.

  12. Central diffraction at ALICE

    Energy Technology Data Exchange (ETDEWEB)

    Laemsae, J W; Orava, R, E-mail: risto.orava@helsinki.fi [Helsinki Insitute of Physics, and Division of Elementary Particle Physics, Department of Physics, PL 64 (Gustaf Haellstroeminkatu 2a), FI-00014 University of Helsinki (Finland)

    2011-02-01

    The ALICE experiment is shown to be well suited for studies of exclusive final states from central diffractive reactions. The gluon-rich environment of the central system allows detailed QCD studies and searches for exotic meson states, such as glueballs, hybrids and new charmonium-like states. It would also provide a good testing ground for detailed studies of heavy quarkonia. Due to its central barrel performance, ALICE can accurately measure the low-mass central systems with good purity. The efficiency of the Forward Multiplicity Detector (FMD) and the Forward Shower Counter (FSC) system for detecting rapidity gaps is shown to be adequate for the proposed studies. With this detector arrangement, valuable new data can be obtained by tagging central diffractive processes.

  13. Problems and Coping Strategies of College English Writ-ing%大学英语写作中存在的问题及应对策略

    Institute of Scientific and Technical Information of China (English)

    熊婧竹

    2014-01-01

    English writing training is an effective way to develop students' thinking and expression ability, also it is a standard to measure the effect of English teaching. The teaching of writing has become an indispensable part of English teaching in the uni-versity, however, it is the weak point of university English teach-ing. Due to the limited English teaching time, teachers need time to cope with university English level test, so they pay less atten-tion on English writing teaching. Aiming at these problems, teachers should combine theory with the reality of students, im-prove teaching methods, lay emphasis on vocabulary accumula-tion, expand English reading, cultivate students' writing skills, meanwhile improving the composition assessment methods,to im-prove the students' English writing ability.%英语写作能力训练是发展学生思维能力和表达能力的有效途径,也是衡量英语教学效果的标准之一。写作教学已经成为大学英语教学中不可或缺的重要组成部分,然而却是大学英语教学中的薄弱环节。由于英语教学的学时有限,以及依然严重的应付四、六级考试的应试写作教学,缺乏系统的写作训练,学生的基本写作能力得不到培养,学生的写作水平提高缓慢。针对这些问题,教师应结合学生的实际,改进教学方法,注重词汇积累,扩大学生的英语阅读量,培养学生的写作技能,同时改进作文评改方法,以提高学生的英语写作能力。

  14. 北京城市气候图系统的初步建立%Preliminary establishment of Beij ing Urban Climate Map(UCMap)system

    Institute of Scientific and Technical Information of China (English)

    贺晓冬; 苗世光; 窦晶晶; 申双和

    2014-01-01

    Modern urbanization and development bring great influence to local climate and environment.However,the application impact of urban climatic information on urban planning and local development is still very limited.This paper takes Beijing as the demonstration case and preliminarily establishes Beijing Urban Climate Map(UCMap) system,to apply urban climatic information to scientific planning and the construction of sustainable city and envi-ronment.The impacts of Beij ing’s natural environment and urban morphology characteristics on urban thermal envi-ronment and urban wind environment are quantitatively analyzed.Urban Climatic Analysis Map(UC-AnMap)within Beij ing urban areas is then formed.Incorporating three-dimensional wind field characteristics numerical simulations of complex building environments in each representative urban climatic spatial unit,Urban Climatic Recommendation Map(UC-ReMap)within Beijing urban areas is finally developed.It shows that nearly closed-type “single center+rings”urban layout within the Fourth Ring Road results in strong thermal load and poor ventilation in most of the areas.Besides,a series of possible climatic spatial planning recommendations are put forward to relieve urban climate problems and improve urban environment.Based on traditional Urban Climate Map,Beijing Urban Climate Map system specifically emphasizes the forecast and evaluation of proposed planning schemes.Furthermore,it particularly stress risk assessment of urban meteorological disasters from the view of early warning in planning,in order to strengthen the ability of disaster prevention and mitigation in Beij ing.%现代城市化发展给当地气候和环境带来巨大影响,然而城市规划和城市发展中对城市气候信息的应用却非常有限。以北京为示范案例,初步建立北京城市气候图系统,将城市气候信息应用于北京可持续发展和生态城市建设。定量分析北京自然环境和典型城市形态因

  15. Central line infections - hospitals

    Science.gov (United States)

    ... risk is higher if you: Are in the intensive care unit (ICU) Have a weakened immune system or serious ... unless you have washed your hands. Tell your nurse if your central line: Gets dirty Is coming ...

  16. Central Data Exchange

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Central Data Exchange (CDX) enables fast, efficient and more accurate environmental data submissions from state and local governments, industry and tribes to...

  17. "Central Station" Londonis

    Index Scriptorium Estoniae

    2000-01-01

    Londoni galeriis Milch seitsme läti, leedu ja eesti kunstniku projekt "Central Station". Kuraatorid Lisa Panting, Sally Tallant. Eestist osalevad Hanno Soans (Catarina Campinoga koostöös valminud video), Kiwa, Kai Kaljo

  18. Central Asian Republic Info

    Data.gov (United States)

    US Agency for International Development — CAR Info is designed and managed by the Central Asian Republic Mission to fill in the knowledge and reporting gaps in existing agency systems for that Mission. It...

  19. Central nervous system

    Science.gov (United States)

    The central nervous system is composed of the brain and spinal cord. Your brain and spinal cord serve as the main "processing center" for your entire nervous system. They control all the workings of your body.

  20. Central nervous system resuscitation

    DEFF Research Database (Denmark)

    McIntosh, T K; Garde, E; Saatman, K E;

    1997-01-01

    Traumatic injury to the central nervous system induces delayed neuronal death, which may be mediated by acute and chronic neurochemical changes. Experimental identification of these injury mechanisms and elucidation of the neurochemical cascade following trauma may provide enhanced opportunities...

  1. Central Bank independence

    OpenAIRE

    Vasile DEDU; Tiberiu STOICA

    2012-01-01

    In this paper we present the key aspects regarding central bank’s independence. Most economists consider that the factor which positively influences the efficiency of monetary policy measures is the high independence of the central bank. We determined that the National Bank of Romania (NBR) has a high degree of independence. NBR has both goal and instrument independence. We also consider that the hike of NBR’s independence played an important role in the significant disin...

  2. EMT Central Offices

    OpenAIRE

    Campo Baeza, Alberto

    2001-01-01

    The brief was the construction of the Central Headquarters of the Municipal Transportation Company of Madrid (EMT) on a site edged by the train lines, near the Atocha train station. = Se trataba de la construcción de la sede central de la empresa EMT de Madrid, en un solar junto a las vías del tren cerca de la estación de Atocha.

  3. Centralization and political accountability

    OpenAIRE

    Hindriks, Jean; Lockwood, Ben

    2004-01-01

    In this paper we abstract from the usual gains and costs of decentralization (e.g. preference matching, spillovers and economies of scale). Instead we compare the political accountability of decentralized governments relative to centralized ones when there is a risk of "bad" governance. We study both the selection and incentive effects of accountability. A key aspect of centralization is to make the politician answerable to multiple constituencies subject to a common budget constraint. Our ma...

  4. SOCRATES Invades Central Europe

    OpenAIRE

    Joseph Slowinski

    1998-01-01

    The objective of this article is to explore the current reality faced by higher education students in Central and Eastern Europe and to draw out the implications of this current reality for policy makers in the future. In the article, I explore the influence of transnational corporations' training programs on education as it currently pertains to Central and Eastern European higher education and employment. In addition, multinational corporate entities exercise influence on European Union pol...

  5. Outsourcing central banking

    OpenAIRE

    Khoury, Sarkis Joseph; Wihlborg , Clas

    2005-01-01

    The literature on Currency Boards (CB) stops at the water edge in terms of dealing with the totality of the functions of a central bank. Monetary policy, and banking supervision can be "outsourced" in an open economy with substantial foreign direct investment (FDI) in the banking sector if political nationalism does not trump economic rationality. An orthodox CB renders the central banking function redundant in terms of interest rate and exchange rate determination. FDI in banking could...

  6. Impact of physical activity levels and diet on central obesity among civil servants in Tamale metropolis

    Directory of Open Access Journals (Sweden)

    Amalba, A.

    2012-04-01

    Full Text Available This study sought to assess the prevalence of central obesity using Waist to Hip ratio as well as establishing the relationship between physical activity, diet and central obesity among civil serv-ants in the Tamale metropolis. This cross-sectional study was conducted between January and Ju-ly, 2011. One hundred and eighty six (186 subjects were involved with 121 being males and 65 be-ing females. The study participants were recruited from an adult population between the ages of 20-59 years. Dietary pattern was assessed using food frequency questionnaires whilst physical activity was determined using the WHO Global physical activity levels questionnaire. The prevalence of central obesity was found to be 31.2%. The prevalence of central obesity was significantly higher (p=0.031 among females (41.5% compared to men (25.6% and also increased with age (p<0.0001. The prevalence of obesity significantly decreased (p = 0.018 from 70.7% via 25.6% to 3.4% as the level of physical activity increased from low through moderate to high. There were no significant associations between dietary pattern and central obesity from this study. Central obesity from this study is high and more common in females. The level of physical activity appears to be a key determinant of the prevalence of central obesity in this study. Preventive actions such as exer-cise and active lifestyles have to be implemented to reduce the tendency for central obesity in this population in particular and the general Ghanaian populace at large.

  7. Pour une approche artistique du cirque au collège : élaboration d'une ingénierie didactique collaborative en EPS en classe de 5ème

    OpenAIRE

    Coasne, Joelle

    2013-01-01

    Notre recherche est une ingénierie didactique de type coopératif (Sensevy & Mercier, 2007) qui s'attache à faire vivre à une classe de 5ème de collège, la complexité du cirque, oeuvre (Chevallard, 1995) au " risque de l'art " (Wallon, 2002), entre " jeux de l'Ilinx et jeux de Mimicry " (Caillois, 1958). Par l'analyse des interactions verbales et corporelles, nous analysons la portée des jeux d'apprentissage qui s'attachent à faire approcher la classe des jeux épistémiques circassiens. La Théo...

  8. Ingénierie système et système de production manufacturière: intégration de l'avolution des exigences dans le PLM

    OpenAIRE

    Messaadia, Mourad

    2008-01-01

    La concurrence impose aux entreprises des contraintes de plus en plus élevées en termes de qualité des produits. Elles sont soumises à des exigences de plus en plus contraignantes. Ainsi, pour ces entreprises modernes, le succès implique de produire le meilleur produit, au plus bas prix, juste à temps. L'INCOSE (Association Internationale de l'Ingénierie Système) a émit le slogan " faster, Better, and Cheaper ". Dans ce contexte, la gestion conjointe des produits et des processus de productio...

  9. CENTRAL PLATEAU REMEDIATION

    Energy Technology Data Exchange (ETDEWEB)

    ROMINE, L.D.

    2006-02-01

    A systematic approach to closure planning is being implemented at the Hanford Site's Central Plateau to help achieve the goal of closure by the year 2035. The overall objective of Central Plateau remediation is to protect human health and the environment from the significant quantity of contaminated material that resulted from decades of plutonium production in support of the nation's defense. This goal will be achieved either by removing contaminants or placing the residual contaminated materials in a secure configuration that minimizes further migration to the groundwater and reduces the potential for inadvertent intrusion into contaminated sites. The approach to Central Plateau cleanup used three key concepts--closure zones, closure elements, and closure process steps--to create an organized picture of actions required to complete remediation. These actions were merged with logic ties, constraints, and required resources to produce an integrated time-phased schedule and cost profile for Central Plateau closure. Programmatic risks associated with implementation of Central Plateau closure were identified and analyzed. Actions to mitigate the most significant risks are underway while high priority remediation projects continue to make progress.

  10. CENTRAL PLATEAU REMEDIATION

    International Nuclear Information System (INIS)

    A systematic approach to closure planning is being implemented at the Hanford Site's Central Plateau to help achieve the goal of closure by the year 2035. The overall objective of Central Plateau remediation is to protect human health and the environment from the significant quantity of contaminated material that resulted from decades of plutonium production in support of the nation's defense. This goal will be achieved either by removing contaminants or placing the residual contaminated materials in a secure configuration that minimizes further migration to the groundwater and reduces the potential for inadvertent intrusion into contaminated sites. The approach to Central Plateau cleanup used three key concepts--closure zones, closure elements, and closure process steps--to create an organized picture of actions required to complete remediation. These actions were merged with logic ties, constraints, and required resources to produce an integrated time-phased schedule and cost profile for Central Plateau closure. Programmatic risks associated with implementation of Central Plateau closure were identified and analyzed. Actions to mitigate the most significant risks are underway while high priority remediation projects continue to make progress

  11. Ocorrência e aspectos ecológicos de metazoários parasitos de peixes do Lago do Parque do Ingá, Maringá, Estado do Paraná = Occurrence and ecological aspects of the metazoan fish parasites from Ingá lake, Maringá, Paraná State

    Directory of Open Access Journals (Sweden)

    Marion Haruko Machado

    2007-07-01

    Full Text Available Nenhum estudo de peixes e parasitos foi realizado, até o momento, no Lago do Parque do Ingá que sofre influências antrópicas desde seu represamento, em 1970. Este trabalho analisou alguns aspectos ecológicos dos parasitos metazoários dos peixes deste lago. Dos peixes analisados, (69,5% estavam parasitados por pelo menos uma espécie de parasito. Foram encontrados 1.372 parasitos pertencentes à Nematoda (larvas e Platyhelminthes (Monogenea e Cestoda, sendo estes os mais prevalentes e numerosos. O encontro de larvas decestóides em Tilapia rendalli e Oreochromis niloticus confirma a importância destas espécies como participantes de níveis tróficos intermediários. A maior abundância de T. rendalli e O. niloticus,no local, pode ser um fator determinante no recrutamento de parasitos. O parasito aproveita-se das espécies de hospedeiros mais abundantes para garantir o desenvolvimento de seu ciclo de vida e também por serem os mais disponíveis à predação pelas aves piscívorasali presentes, o que torna o local de grande importância para a sustentação do ciclo de vida desses parasitos. A baixa diversidade de endoparasitos coletados pode ser justificada pela presença de metais pesados – Cu e Pb – no sedimento, o que deve estar interferindo nodesenvolvimento dos invertebrados, possíveis hospedeiros intermediários.Ingá lake was dammed in 1970 and, since then, no study on fish and parasites had been done, but it has suffered anthropic influences. This study analyzed some ecological aspects of the metazoan parasites form this lake. From analyzed fish, 69.5% had at least one species of parasite. Among them, 1.372 parasites were found, prevailing Nematoda (larvae and Platyhelminthes (Monogenea and Cestoda. The discovery of cestode larvae in Tilapia rendalli and Oreochromis nitolicus confirms the importance of these species as participants of intermediate trophic levels. The great number of Tilapia rendalli and Oreochromis nitolicus

  12. Colloquium on Central Asia

    International Nuclear Information System (INIS)

    This colloquium on Azerbaijan was organized by the direction of international relations of the French Senate and the French center of foreign trade (CFCE). This document gathers the interventions of the participants and the debates with the audience following these interventions. The topics treated concern: - the present day political-economical situation of Central Asia countries (problem of borders, relations with Russia and China); - the economies of Central Asia countries: short term problems and medium-term perspectives; - the relations with the European Union (political, economical, trade and investments, perspectives); - the European energy stakes of Caspian sea (oil and gas reserves, development of hydrocarbon resources, exploitation and transport constraints, stakes for Europe and France); - TotalFinaElf company in Central Asia (Kazakhstan, Azerbaijan, enclavement problem); - the economical impacts of the TRACECA pathway (Transport Corridor Europe Caucasus Asia). (J.S.)

  13. The Naive Central Banker

    Directory of Open Access Journals (Sweden)

    Marcelo de Carvalho Griebeler

    2015-09-01

    Full Text Available There has been in some countries a trend of assigning other functions to central banks besides price stability. The most suggested function to be added to monetary authority’s obligations is to pursue economic growth or full employment. In this paper we characterize the behavior and analyse the optimal monetary policy of, what we call, a naive central banker. We describe the naive behavior as one that does face the inflation-unemployment trade-off, but it tries to minimize both variables simultaneously. Our findings, both under discretion and commitment, indicate that the naive central banker delivers lower expected inflation and inflation variance than the benchmark behavior whenever the economy is rigid enough. However, the degree of conservativeness also affects this result, such that the less conservative the naive policymaker, the more rigidity is necessary.

  14. SOCRATES Invades Central Europe

    Directory of Open Access Journals (Sweden)

    Joseph Slowinski

    1998-04-01

    Full Text Available The objective of this article is to explore the current reality faced by higher education students in Central and Eastern Europe and to draw out the implications of this current reality for policy makers in the future. In the article, I explore the influence of transnational corporations' training programs on education as it currently pertains to Central and Eastern European higher education and employment. In addition, multinational corporate entities exercise influence on European Union policy through the role of lobby organizations and activities. I explore the influence of these practices on education with an emphasis on the emerging importance of Western language skills. In addition, I focus on the European Union and its efforts to expand into Central and Eastern Europe in order to provide a focal point for analysis.

  15. ORIC central region calculations

    International Nuclear Information System (INIS)

    The central region for the K = 100 Oak Ridge Isochronous Cyclotron, ORIC, will be modified to provide better orbit centering, focusing of orbits in the axial direction, and phase selection, in order to improve extraction efficiency, and reduce radioactive activation of cyclotron components. The central region is specifically designed for the acceleration of intense light ion beams such as 60 MeV protons and 15--100 MeV alphas. These beams will be used in the production of radioactive atoms in the Radioactive Ion Beam Project at Oak Ridge National Laboratory

  16. Hale Central Peak

    Science.gov (United States)

    2004-01-01

    19 September 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows some of the mountains that make up the central peak region of Hale Crater, located near 35.8oS, 36.5oW. Dark, smooth-surfaced sand dunes are seen to be climbing up the mountainous slopes. The central peak of a crater consists of rock brought up during the impact from below the crater floor. This autumn image is illuminated from the upper left and covers an area approximately 3 km (1.9 mi) across.

  17. 对学术期刊实行"编校合一"的思考%Pondering on the Implementation of "Editing-Proofread- ing Integration"for Academic Journals

    Institute of Scientific and Technical Information of China (English)

    杨呈祥

    2015-01-01

    The"editing-proofreading integration"system prevail-ing in the current publishing field is explored in this paper. The definition of"editing-proofreading integration"and the difference between editing and proofreading are analyzed first, and the rea-sons why more and more academic journals are implementing"editing-proofreading integration" are also analyzed, and then the scientificalness and shortcomings of the "editing-proofread-ing integration"system are expounded. The writer holds that it is scientific and feasible to implement the"editing-proofreading in-tegration"system for academic journals in the new situation, and the shortcomings can be eliminated through appropriate means.%本文对目前出版界颇为盛行的"编校合一"制度进行了探讨.首先分析了"编校合一"的概念以及编辑与校对两个岗位的区别,并对越来越多的学术期刊实行"编校合一"的原因进行了分析,继而阐明了"编校合一"制度的科学性以及存在的弊端.认为在新时期下学术期刊实行"编校合一"制度具备科学性和可行性,其弊端可以通过合适的手段消除.

  18. Channeling the Central Dogma.

    Science.gov (United States)

    Calabrese, Ronald L

    2014-05-21

    How do neurons and networks achieve their characteristic electrical activity, regulate this activity homeostatically, and yet show population variability in expression? In this issue of Neuron, O'Leary et al. (2014) address some of these thorny questions in this theoretical analysis that starts with the Central Dogma. PMID:24853932

  19. Central Dogma Goes Digital.

    Science.gov (United States)

    Lin, Yihan; Elowitz, Michael B

    2016-03-17

    In this issue of Molecular Cell, Tay and colleagues (Albayrak et al., 2016) describe a new technique to digitally quantify the numbers of protein and mRNA in the same mammalian cell, providing a new way to look at the central dogma of molecular biology. PMID:26990983

  20. Central areolar choroidal dystrophy.

    NARCIS (Netherlands)

    Boon, C.J.F.; Klevering, B.J.; Cremers, F.P.M.; Zonneveld-Vrieling, M.N.; Theelen, T.; Hollander, A.I. den; Hoyng, C.B.

    2009-01-01

    OBJECTIVE: To describe the clinical characteristics, follow-up data and molecular genetic background in a large group of patients with central areolar choroidal dystrophy (CACD). DESIGN: Retrospective case series study. PARTICIPANTS: One hundred three patients with CACD from the Netherlands. METHODS

  1. [Central manifestations of dystrophinopathies].

    Science.gov (United States)

    Cuisset, J-M; Rivier, F

    2015-12-01

    The dystrophin gene involved in Duchenne and Becker muscular dystrophy is expressed in three main tissues resulting in clinical manifestations: skeletal muscle, heart and central nervous system. The 6 different existing dystrophins in the brain may play a role in the maturation and plasticity of neuronal synapses in particular by their functions in clustering and stabilization of different receptors at the post synaptic membrane. The possibility of an intellectual deficiency in Duchenne muscular dystrophy is known from the original description by Duchenne himself. Current data are in line with a constant cognitive impairment with a Gaussian curve shifted intellectual quotient (IQ) at -1 standard deviation from the standard population with an average IQ around 80. Clinical manifestations suggestive of a central nervous system involvement can affect all dystrophinopathies, including isolated central presentations without myopathic sign. The phenotypic spectrum appears broader and more subtle than non specific intellectual deficiency. The isolated or shared involvement of specific cognitive functions is possible (memory functions, executive functions, attention) with or without intellectual deficiency. Autism spectrum disorders are also among the encountered events. In clinical practice, it seems worth to ask for a measurement of serum creatine kinase (CK) in these different situations, keeping in mind that pure forms of central dystrophinopathies with a normal CK level have been recently reported. PMID:26773588

  2. Retiring the central executive.

    Science.gov (United States)

    Logie, Robert H

    2016-10-01

    Reasoning, problem solving, comprehension, learning and retrieval, inhibition, switching, updating, or multitasking are often referred to as higher cognition, thought to require control processes or the use of a central executive. However, the concept of an executive controller begs the question of what is controlling the controller and so on, leading to an infinite hierarchy of executives or "homunculi". In what is now a QJEP citation classic, Baddeley [Baddeley, A. D. (1996). Exploring the central executive. Quarterly Journal of Experimental Psychology, 49A, 5-28] referred to the concept of a central executive in cognition as a "conceptual ragbag" that acted as a placeholder umbrella term for aspects of cognition that are complex, were poorly understood at the time, and most likely involve several different cognitive functions working in concert. He suggested that with systematic empirical research, advances in understanding might progress sufficiently to allow the executive concept to be "sacked". This article offers an overview of the 1996 article and of some subsequent systematic research and argues that after two decades of research, there is sufficient advance in understanding to suggest that executive control might arise from the interaction among multiple different functions in cognition that use different, but overlapping, brain networks. The article concludes that the central executive concept might now be offered a dignified retirement. PMID:26821744

  3. Centralizers of spin subalgebras

    Science.gov (United States)

    Arizmendi, Gerardo; Herrera, Rafael

    2015-11-01

    We determine the centralizers of certain isomorphic copies of spin subalgebras spin(r) in so(dr m), where dr is the dimension of a real irreducible representation of Clr0, the even Clifford algebra determined by the positive definite inner product on Rr, where r, m ∈ N.

  4. Outsourcing central banking

    DEFF Research Database (Denmark)

    Khoury, Sarkis Joseph; Wihlborg, Clas

    2005-01-01

    The literature on Currency Boards (CB) stops at the water edge in terms of dealing with the totality of the functions of a central bank. Monetary policy, and banking supervisioncan be "outsourced" in an open economy with substantial foreign direct investment (FDI)in the banking sector if politica...

  5. Sustainability Assessment of a Self-Consumption Wood-Energy Chain on Small Scale for Heat Generation in Central Italy

    Directory of Open Access Journals (Sweden)

    Stefano Verani

    2015-06-01

    Full Text Available The sustainability of a small-scale self-consumption wood-energy chain for heat generation in central Italy was analyzed from a technical, economic and energetic point of view. A micro-chain was developed within the CRA-ING farm at Monterotondo (Rome, Italy: The purpose of this system was to produce biomass for supplying a heating plant within the CRA-ING property as a substitute for diesel fuel. A poplar short rotation coppice, established with clones AF2, AF6 and Monviso, fed the micro-chain. The rotation was biennial. The average plantation production (Mgd.m.·ha−1·year−1 was 10.2, with a maximum of 13.53 for the twin-rows AF2 and a minimum of 8.00 for the single-row Monviso. The economic assessment was based on the Net Present Value (NPV method and the equivalent annuity cost, and found an average saving of 15.60 €·GJ−1 of heat generated by the wood chips heating system in comparison with the diesel heating system over a 10 year lifetime of the thermal power plant. The energy assessment of the poplar plantation, carried out using the Gross Energy Requirements method, reported an energy output/input ratio of 12.3. The energy output/input ratio of the whole micro-chain was 4.5.

  6. Central Station Design Options

    DEFF Research Database (Denmark)

    2011-01-01

    The purpose of EDISON Work Package 4.1 is the evaluation of possible Central (charging) Stations design options for making possible the public charging of Electric Vehicles (EVs). A number of scenarios for EVs are assessed, with special emphasis on the options of Fast Charging and Battery Swapping...... charging, rated at 50 kW, fast charging would be easier in both Denmark and Bornholm scenarios. For each scenario and charging power level, the possible number of EVs is estimated and finally architectural design options are proposed. Technical assessment is performed for evaluating the benefits.......g. due to vandalism, the charge supply circuit is disconnected. More electrical vehicles on the market are capable today of quick charging up to 50 kW power level. The feasibility of Central Stations with fast charging/swapping option, their capacity, design, costs and grid impact, as well as battery...

  7. Forward central jets correlations

    International Nuclear Information System (INIS)

    The azimuthal correlation between forward and central jets has been measured in pp collisions with the CMS detector at the LHC at the centre-of-mass energy of 7 TeV. The forward jet is required to be reconstructed in the hadronic forward calorimeter, within the pseudo-rapidity 3.2t>35 GeV. The measurement of the azimuthal angle between the jets is performed for different separations in pseudo-rapidity between the jets, with the largest separation being 7.5 units. The measurement is repeated for two subsamples of events, one in which an additional jet is required between the forward and the central jet, and one where the additional jet is vetoed. The measurement is compared to several different Monte Carlo models and tunes.

  8. Ferrule Designs and Stress Distribution in Endodontically Treated Upper Central Incisors: 3D Finite Element Analysis

    Directory of Open Access Journals (Sweden)

    A. Hassan Ahangari

    2008-09-01

    Full Text Available Objective: The main goal of this study was to evaluate stress distribution of endodonti-cally treated maxillary central incisors restored with glass fiber posts, composite resin cores, and crowns with different ferrule designs.Materials and Methods: Four three-dimensional models of a maxillary central incisor were modeled in SolidWorks 2006. Tooth with no ferrule, tooth with a 2 mm circumferen-tial ferrule, tooth with a 2 mm beveled ferrule and tooth with a 0.5 mm circumferential ferrule. The teeth were restored with glass fiber posts, composite resin cores, and full ce-ramics crowns. Each model was loaded (1 N on the palatal side at an angle of 45 degrees to tooth long axis. Von Mises stress findings along the inner surface of the root canals were assessed and compared.Results: The Von Mises Stress at CEJ was the highest in the model without a ferrule when compared to the other models (without ferrule 0.0696, short ferrule 0.0492, cylindrical fer-rule 0.0248, and beveled ferrule 0.0387 MPa.Conclusion: Endodontically treated maxillary central incisors with a ferrule length vary-ing between 0.5 mm and 2.0 mm exhibit lower stress distribution compared to those with-out a ferrule. Keeping a long ferrule is suggested to decrease the stress at the cervical area of restored teeth.

  9. Measuring Central Bank Communication:

    OpenAIRE

    David Lucca; Francesco Trebbi

    2008-01-01

    We present a new automated, objective and intuitive scoring method to measure the content of central bank communication about future policy rate moves. We apply the methodology to statements released by the Federal Open Market Commitee (FOMC) after monetary policy meetings. Using high-frequency financial data, we find that yields on short-term risk-free nominal rates respond both to changes in policy rates and the content of the statements, whereas, medium and long-term rates only respond to ...

  10. Central nervous system diseases

    International Nuclear Information System (INIS)

    It is shown that roentgenological examination plays an important role in diagnosis of central nervous system diseases in children. The methods of roentgenological examinations are divided into 3 groups: roentgenography without contrast media (conventional roentgenography), roentgenography with artificial contrasting of liquor space (ventriculopneumoencelography, myelography) and contrasting of brain and spinal blood vessels (angiography). Conventional contrastless roentgenography of skull and vertebral column occupies leadership in diagnosis of brain neoplasms and some vascular diseases

  11. Centrality Measures in Networks

    CERN Document Server

    Bloch, Francis; Tebaldi, Pietro

    2016-01-01

    We show that although the prominent centrality measures in network analysis make use of different information about nodes' positions, they all process that information in an identical way: they all spring from a common family that are characterized by the same simple axioms. In particular, they are all based on a monotonic and additively separable treatment of a statistic that captures a node's position in the network.

  12. FNAL central email systems

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jack; Lilianstrom, Al; Pasetes, Ray; Hill, Kevin; /Fermilab

    2004-10-01

    The FNAL Email System is the primary point of entry for email destined for an employee or user at Fermilab. This centrally supported system is designed for reliability and availability. It uses multiple layers of protection to help ensure that: (1) SPAM messages are tagged properly; (2) All mail is inspected for viruses; and (3) Valid mail gets delivered. This system employs numerous redundant subsystems to accomplish these tasks.

  13. Centrally Banked Cryptocurrencies

    OpenAIRE

    Danezis, G.; Meiklejohn, S.

    2016-01-01

    Current cryptocurrencies, starting with Bitcoin, build a decentralized blockchain-based transaction ledger, maintained through proofs-of-work that also serve to generate a monetary supply. Such decentralization has benefits, such as independence from national political control, but also significant limitations in terms of computational costs and scalability. We introduce RSCoin, a cryptocurrency framework in which central banks maintain complete control over the monetary supply, but rely on...

  14. Central simple Poisson algebras

    Institute of Scientific and Technical Information of China (English)

    SU; Yucai; XU; Xiaoping

    2004-01-01

    Poisson algebras are fundamental algebraic structures in physics and symplectic geometry. However, the structure theory of Poisson algebras has not been well developed. In this paper, we determine the structure of the central simple Poisson algebras related to locally finite derivations, over an algebraically closed field of characteristic zero.The Lie algebra structures of these Poisson algebras are in general not finitely-graded.

  15. Centrally Banked Cryptocurrencies

    OpenAIRE

    Danezis, George; Meiklejohn, Sarah

    2015-01-01

    Current cryptocurrencies, starting with Bitcoin, build a decentralized blockchain-based transaction ledger, maintained through proofs-of-work that also generate a monetary supply. Such decentralization has benefits, such as independence from national political control, but also significant limitations in terms of scalability and computational cost. We introduce RSCoin, a cryptocurrency framework in which central banks maintain complete control over the monetary supply, but rely on a distribut...

  16. Dinamismo econômico e batismos de ingênuos: a libertação do ventre da escrava em Casa Branca e Iguape, província de São Paulo (1871-1885

    Directory of Open Access Journals (Sweden)

    José Flávio Motta

    2008-01-01

    Full Text Available Estudamos os batismos de ingênuos registrados nas localidades paulistas de Iguape e Casa Branca entre 1871 e 1885. Nesse período, houve em Iguape o esmorecimento do dinamismo econômico assentado no cultivo de arroz destinado ao mercado interno. Já Casa Branca achava-se próxima à fronteira da expansão da lavoura cafeeira na província. Com a ênfase posta na comparação entre esses dois municípios, com vistas a explorar o condicionamento exercido por seus díspares panos de fundo econômicos, analisamos as características dos registros aludidos. Observamos a freqüência dos batizados no tempo, bem como computamos a distribuição, de acordo com a condição de legitimidade, das crianças nascidas de mães escravas após a promulgação da Lei do Ventre Livre. Acompanhamos o comportamento da defasagem temporal entre a data do nascimento e a do batismo. Avançamos, com fundamento em dois estudos de caso, um para cada uma das localidades selecionadas, algumas considerações acerca dos intervalos intergenésicos. Por fim, voltamos nossa atenção para a condição social de padrinhos e madrinhas. Mostraram-se muito expressivas, regra geral, as disparidades entre Iguape e Casa Branca.We study the baptisms of ingênuos registered in the localities of Iguape and Casa Branca, both in the province of São Paulo, in the period 1871-1885. Iguape, in those years, saw a slackening of the economic dynamism based on rice cultivation for the internal market. Casa Branca, on the other hand, was near the expansion frontier of coffee culture in the province. We emphasize the comparison between the characteristics of the registers of baptisms of ingênuos preserved for those two cities to explore the impact of their different economic contexts. We observe the frequency in time of the baptisms of children born of slave mothers after de promulgation of the Ventre-Livre Law. In addition, we compute the distribution of baptisms according to legitimacy

  17. “FORESEEING, THRIFTY ECONOMICAL”? THE PROVIDENT CLOTH ING AND SUPPLY COMPANY AND WORKING CLASS CONSUMER CREDIT IN THE UNITED KINGDOM, 1925-60

    Directory of Open Access Journals (Sweden)

    Sean O'Connell

    2004-01-01

    Full Text Available Historical surveys of consumer credit in the United Kingdom identify the importance of check trading without documenting its magnitude or development. Check traders provided promissory notes redeemable with local retailers, who paid discounts in return for the custom. The Provident Clothing and Supply Company established the system in 1880 and by 1910 had obtained an annual turnover of £1,000,000. Checks were used to purchase goods at what Provident argued were “ordinary retail prices.” While critics claimed the system offered poor credit bargains check trading remained unregulated. Using Provident’s records the paper offers a unique opportunity to assess the size and nature of an institution central to many working class budgets.

  18. Exploitation sémantique des modèles d'ingénierie : application à la modélisation des réservoirs pétroliers

    OpenAIRE

    Silveira Mastella, Laura

    2010-01-01

    Ce travail propose des solutions innovantes en vue de l'exploitation des modèles d'ingénierie hétérogènes. Il prend pour exemple le domaine de la prospection pétrolière. Les stratégies de prospection sont élaborées à partir de représentations tridimensionnelles du sous-sol appelées modèles géologiques. Ceux-ci reposent sur un grand nombre de données hétérogènes générées au fur et à mesure de la conduite de l'exploration par des activités telles que la prospection séismique, les forages, l'int...

  19. Le français, clé de l’avenir professionnel de l’étudiant : exemple de la formation des ingénieurs en télécommunications

    Directory of Open Access Journals (Sweden)

    Mª Ángeles Lence

    2014-12-01

    Full Text Available Cet article veut attirer l’attention sur l’importance de la langue française dans la formation des étudiants universitaires, non seulement au niveau académique pour qu’ils puissent poursuivre leurs études dans un pays francophone, mais aussi au niveau professionnel pour leur future immersion sur le marché de l’emploi. Dans le contexte de la globalisation qui impose la maîtrise de l’anglais comme un requis inexcusable dans les offres d’emploi, la connaissance d’une deuxième langue étrangère accorde une valeur de plus au curriculum des diplômés espagnols, en les mettant en conditions égales avec leurs homologues européens, en augmentant leurs possibilités de travail au niveau international, en les rendant enfin aussi compétitifs que les diplômés d’autres universités où le bagage de deux langues étrangères conditionne l’obtention du diplôme d’ingénieur. Comme exemple, nous exposons comment les étudiants peuvent apprendre le français dans les études actuelles de Grado en Ingénierie Technique de Télécommunications de l’Universitat Politècnica de València (UPV, en comparant en même temps avec l’apprentissage des langues dans une École homologue en France.

  20. Central osteosclerosis with trichothiodystrophy

    International Nuclear Information System (INIS)

    Trichothiodystrophy (TTD) is a rare, autosomal recessive, multisystem disorder associated with defects in nucleotide excision repair. We report a 7-year-old boy with TTD due to mutation in the XPD gene. The patient has classic features of this condition, including brittle, sulphur-deficient hair, ichthyosis, growth retardation and developmental delay. In addition, he has radiological evidence of progressive central osteosclerosis. Although similar radiological findings have previously been reported in a small number of patients, this association is not widely recognised. We review the radiological findings in this and other similar cases and discuss the natural history of these bony changes. (orig.)

  1. Solar thermal central receivers

    International Nuclear Information System (INIS)

    Market issues, environmental impact, and technology issues related to the Solar Central Receiver concept are addressed. The rationale for selection of the preferred configuration and working fluid are presented as the result of a joint utility-industry analysis. A $30 million conversion of Solar One to an external molten salt receiver would provide the intermediate step to a commercial demonstration plant. The first plant in this series could produce electricity at 11.2 cents/kWhr and the seventh at 8.2 cents/kWhr, completely competitive with projected costs of new utility plants in 1992

  2. Floods in Central China

    Science.gov (United States)

    2002-01-01

    This pair of true- and false-color images from the Moderate resolution Imaging Spectroradiometer (MODIS) shows flooding in central China on July 4, 2002. In the false-color image vegetation appears orange and water appears dark blue to black. Because of the cloud cover and the fact that some of the water is filled with sediment, the false-color image provides a clearer picture of where rivers have exceeded their banks and lakes have risen. The river in this image is the Yangtze River, and the large lake is the Poyang Hu. Credits: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

  3. Central ignition scenarios for TFTR

    International Nuclear Information System (INIS)

    The possibility of obtaining ignition in TFTR by means of very centrally peaked density profiles is examined. It is shown that local central alpha heating can be made to exceed local central energy losses (''central ignition'') under global conditions for which Q greater than or equal to 1. Time dependent 1-D transport simulations show that the normal global ignition requirements are substantially relaxed for plasmas with peaked density profiles. 18 refs., 18 figs

  4. Central Banking after the Crisis

    OpenAIRE

    Frederick S. Mishkin

    2013-01-01

    This paper explores where central banking is heading after the recent financial crisis. First it discusses the central bank consensus before the crisis and then outlines the key facts learned from the crisis that require changes in the way central banks conduct their business. Finally, it discusses four main areas in which central banks are altering their policy frameworks: 1) the interaction between monetary and financial stability policies, 2) nonconventional monetary policy, 3) risk manage...

  5. Three myths about central banks

    OpenAIRE

    Geoffrey P. Miller

    2002-01-01

    Do central banks control the business cycle? Should price stability be their only monetary policy goal? Do politicians give up a degree of power and gain nothing personally when they grant central banks independence? This Commentary argues that none of these widely held notions is true. The Commentary is based on a speech presented to participants at the conference on the Origins and Evolution of Central Banking, sponsored by the Central Bank Institute of the Federal Reserve Bank of Cleveland...

  6. Centralized vs. De-centralized Multinationals and Taxes

    DEFF Research Database (Denmark)

    Nielsen, Søren Bo; Raimondos-Møller, Pascalis; Schjelderup, Guttorm

    2005-01-01

    The paper examines how country tax differences affect a multinational enterprise's choice to centralize or de-centralize its decision structure. Within a simple model that emphasizes the multiple conflicting roles of transfer prices in MNEs - here, as a strategic pre-commitment device and a tax m...... manipulation instrument -, we show that (de-)centralized decisions are more profitable when tax differentials are (small) large.Keywords: Centralized vs. de-centralized decisions, taxes, MNEs.JEL-Classification: H25, F23, L23....

  7. en los pivotes centrales

    Directory of Open Access Journals (Sweden)

    Reynaldo Roque Rodés

    2005-01-01

    Full Text Available Se hace una revisión y comentarios sobre las ventajas y limitantes del empleo del LEPA (Low Enery Precision Aplication en los sistemas de riego de pivotes centrales. Estos sistemas o filosofía de manejo del agua para condiciones de escasez o mala calidad del líquido es una alternativa viable para la producción de alimentos. Introducida en la década del 80 en las planicies del sur de Texas, donde la alta evaporación del agua y la necesidad de regar grandes áreas con pivotes centrales obligaba a la búsqueda de una alternativa para incrementar al máximo la eficiencia de aplicación del riego. Aún en fase de estudio e introducción en Cuba para áreas específicas, puede ser una solución de incremento de los rendimientos de los cultivos, empleando menos agua y aguas con calidad limitada

  8. Central Sumatra enjoys success

    Energy Technology Data Exchange (ETDEWEB)

    Wongsosantiko, A.

    1977-05-02

    The Sihapas group contains the most prolific oil producing zones in the Central Sumatra Basin. It represents the transgressive, coarse clastic sequence deposited during the early Miocene. Some of these sandstone grade laterally into siltstones and shales of the Telisa Formation, believed to be a major source of rock for Central Sumatra oil. Recent exploratory wells drilled between the mountain front and coastal plain areas have provided more data for stratigraphic studies. These have resulted in subdivision of the lower Miocene transgressive sequence into discrete rock-stratigraphic units. The former Sihapas Formation has subsequently been elevated to group rank and now consists of several formations with the Duri Formation as the uppermost sand unit. This study covers Caltex's areas of operation, which includes the area between the Kampar River of the south, the Barumum River to the north, the Malacca Straits to the east, and the Barisan Mt. to the west. A basic map shows the regional scene, while a stratigraphic chart shows the lithology.

  9. Centrality Measures in Urban Networks

    CERN Document Server

    Crucitti, P; Porta, S; Crucitti, Paolo; Latora, Vito; Porta, Sergio

    2005-01-01

    Centrality has revealed crucial for understanding the structural order of complex relational networks. Centrality is also relevant for various spatial factors affecting human life and behaviors in cities. We present a comprehensive study of centrality distributions over geographic networks of urban streets. Four different measures of centrality, namely closeness, betweenness, straightness and information, are compared over eighteen 1-square-mile samples of different world cities. Samples are represented by primal geographic graphs, i.e. valued graphs defined by metric rather than topologic distance where intersections are turned into nodes and streets into edges. The spatial behavior of centrality indexes over the networks is investigated graphically by means of colour-coded maps. The results indicate that a spatial analysis, that we term Multiple Centrality Assessment(MCA), grounded not a single but on a set of different centrality indices, allows an extended comprehension of the city structure, nicely captu...

  10. Sucker rod centralizer

    Energy Technology Data Exchange (ETDEWEB)

    Rivas, O.; Newski, A.

    1989-10-03

    This patent describes a device for centralizing at least one sucker rod within a production pipe downhole in a well and for reducing frictional forces between the pipe and at least one sucker rod. It comprises an elongate, substantially cylindrical body member having a longitudinal axis, a plurality of slots within the member and a rotatable member mounted within each slot, each of the plurality of slots has its major dimension along a first axis parallel to the longitudinal axis of the body member and is oriented with respect to the other seats so as to form a helicoidal array for maximizing the total surface contact area between the rotatable members and the pipe and for decreasing the forces acting on each rotatable member.

  11. Centralizer for well casing

    International Nuclear Information System (INIS)

    This patent describes an improved centralizer for centering a well casing in a wellbore. It comprises: a first anchor adapted to fit around and be securely fixed to the casing, the first anchor being threaded on its external surface; a first collar adapted to fit around and be threadedly engaged by the first anchor; a second collar adapted to fit around and free to rotate and move axially with respect to the casing; a second anchor adapted to fit around and be securely fixed to the casing spaced from the first anchor and comprising a bearing surface for restraining axial movement of the second collar along the casing; and metallic straps extending between the first collar and the second collar, and being securely fixed to each

  12. UA2 central calorimeter

    CERN Multimedia

    The UA2 central calorimeter measured the energy of individual particles created in proton-antiproton collisions. Accurate calibration allowed the W and Z masses to be measured with a precision of about 1%. The calorimeter had 24 slices like this one, each weighing 4 tons. The slices were arranged like orange segments around the collision point. Incoming particles produced showers of secondary particles in the layers of heavy material. These showers passed through the layers of plastic scintillator, generating light which was taken by light guides (green) to the data collection electronics. The amount of light was proportional to the energy of the original particle. The inner 23 cm of lead and plastic sandwiches measured electrons and photons; the outer 80 cm of iron and plastic sandwiches measured strongly interacting hadrons. The detector was calibrated by injecting light through optical fibres or by placing a radioactive source in the tube on the bottom edge.

  13. UA1 central detector

    CERN Multimedia

    The UA1 central detector was crucial to understanding the complex topology of proton-antiproton events. It played a most important role in identifying a handful of Ws and Zs among billions of collisions. The detector was a 6-chamber cylindrical assembly 5.8 m long and 2.3 m in diameter, the largest imaging drift chamber of its day. It recorded the tracks of charged particles curving in a 0.7 Tesla magnetic field, measuring their momentum, the sign of their electric charge and their rate of energy loss (dE/dx). Atoms in the argon-ethane gas mixture filling the chambers were ionised by the passage of charged particles. The electrons which were released drifted along an electric field shaped by field wires and were collected on sense wires. The geometrical arrangement of the 17000 field wires and 6125 sense wires allowed a spectacular 3-D interactive display of reconstructed physics events to be produced.

  14. The exhibition"La France au CERN" was inaugurated by Danièle Hulin, Directrice adjointe Secteur Physique, Chimie, Sciences pour l'Ingénieur (PCSI), Ministère délégué à l'Enseignement supérieur et à la recherche.

    CERN Document Server

    Patrice Loïez

    2005-01-01

    The exhibition"La France au CERN" was inaugurated by Danièle Hulin, Directrice adjointe Secteur Physique, Chimie, Sciences pour l'Ingénieur (PCSI), Ministère délégué à l'Enseignement supérieur et à la recherche.

  15. Flux analysis of central metabolic pathways in Geobactermetallireducens during reduction of solubleFe(III)-NTA

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Yinjie J.; Chakraborty, Romy; Garcia-Martin, Hector; Chu,Jeannie; Hazen, Terry C.; Keasling, Jay D.

    2007-01-01

    We analyzed the carbon fluxes in the central metabolism ofGeobacter metallireducens strain GS-15 using 13C isotopomer modeling.Acetate labeled in the 1st or 2nd position was the sole carbon source,and Fe-NTA was the sole terminal electron acceptor. The measured labeledacetate uptake rate was 21 mmol/gdw/h in the exponential growth phase.The resulting isotope labeling pattern of amino acids allowed an accuratedetermination of the in vivo global metabolic reaction rates (fluxes)through the central metabolic pathways using a computational isotopomermodel. The tracer experiments showed that G. metallireducens containedcomplete biosynthesis pathways for essential metabolism, and this strainmight also have an unusual isoleucine biosynthesis route (usingacetyl-CoA and pyruvate as the precursors). The model indicated that over90 percent of the acetate was completely oxidized to CO2 via a completetricarboxylic acid (TCA) cycle while reducing iron. Pyruvate carboxylaseand phosphoenolpyruvate carboxykinase were present under theseconditions, but enzymes in the glyoxylate shunt and malic enzyme wereabsent. Gluconeogenesis and the pentose phosphate pathway were mainlyemployed for biosynthesis and accounted for less than 3 percent of totalcarbon consumption. The model also indicated surprisingly highreversibility in the reaction between oxoglutarate and succinate. Thisstep operates close to the thermodynamic equilibrium possibly becausesuccinate is synthesized via a transferase reaction, and the conversionof oxoglutarate to succinate is a rate limiting step for carbonmetabolism. These findings enable a better understanding of therelationship between genome annotation and extant metabolic pathways inG. metallireducens.

  16. In the presence of danger:the extracellular matrix defensive response to central nervous system injury

    Institute of Scientific and Technical Information of China (English)

    Lyn B. Jakeman; Kent E. Williams; Bryan Brautigam

    2014-01-01

    Glial cells in the central nervous system (CNS) contribute to formation of the extracellular matrix, which provides adhesive sites, signaling molecules, and a diffusion barrier to enhance efifcient neurotransmission and axon potential propagation. In the normal adult CNS, the extracellular matrix (ECM) is relatively stable except in selected regions characterized by dynamic remodel-ing. However, after trauma such as a spinal cord injury or cortical contusion, the lesion epicenter becomes a focus of acute neuroinlfammation. The activation of the surrounding glial cells leads to a dramatic change in the composition of the ECM at the edges of the lesion, creating a perile-sion environment dominated by growth inhibitory molecules and restoration of the peripheral/central nervous system border. An advantage of this response is to limit the invasion of damaging cells and diffusion of toxic molecules into the spared tissue regions, but this occurs at the cost of inhibiting migration of endogenous repair cells and preventing axonal regrowth. The following review was prepared by reading and discussing over 200 research articles in the ifeld published in PubMed and selecting those with signiifcant impact and/or controversial points. This article highlights structural and functional features of the normal adult CNS ECM and then focuses on the reactions of glial cells and changes in the perilesion border that occur following spinal cord or contusive brain injury. Current research strategies directed at modifying the inhibitory perile-sion microenvironment without eliminating the protective functions of glial cell activation are discussed.

  17. [Central auditory prosthesis].

    Science.gov (United States)

    Lenarz, T; Lim, H; Joseph, G; Reuter, G; Lenarz, M

    2009-06-01

    Deaf patients with severe sensory hearing loss can benefit from a cochlear implant (CI), which stimulates the auditory nerve fibers. However, patients who do not have an intact auditory nerve cannot benefit from a CI. The majority of these patients are neurofibromatosis type 2 (NF2) patients who developed neural deafness due to growth or surgical removal of a bilateral acoustic neuroma. The only current solution is the auditory brainstem implant (ABI), which stimulates the surface of the cochlear nucleus in the brainstem. Although the ABI provides improvement in environmental awareness and lip-reading capabilities, only a few NF2 patients have achieved some limited open set speech perception. In the search for alternative procedures our research group in collaboration with Cochlear Ltd. (Australia) developed a human prototype auditory midbrain implant (AMI), which is designed to electrically stimulate the inferior colliculus (IC). The IC has the potential as a new target for an auditory prosthesis as it provides access to neural projections necessary for speech perception as well as a systematic map of spectral information. In this paper the present status of research and development in the field of central auditory prostheses is presented with respect to technology, surgical technique and hearing results as well as the background concepts of ABI and AMI. PMID:19517084

  18. CENTRAL EUROPE: Role models

    International Nuclear Information System (INIS)

    Hungary is one of the newcomers to the CERN fold, having joined in 1992. The country's contributions are naturally in line with its slender resources and are not as immediately visible as those of the major Western European Member States. However the approach used and its consequent successes provide a good role model for a smaller nation in an international research environment. This was reflected on 24 September at a meeting of the European Committee for Future Accelerators (ECFA) convened in Budapest, continuing an ECFA tradition of holding meetings in national centres to learn more about the physics programmes of different countries. This tradition started with visits to major West European Centres, but last year ECFA held a meeting in Warsaw, its first in a central European country. By far the largest Hungarian population centre, Budapest is also a hub for national research in this sector, with university centres and the KFKI Research Institute for Particle and Nuclear Physics of the National Academy of Sciences. However important research work is also carried out in the eastern city of Debrecen. Hungarians look back to the classic investigations of Eotvos early this century as the starting point of their national tradition in fundamental physics. (In the mid-80s, these experiments briefly came back into vogue when there was a suggestion of an additional 'fifth force' contribution to nuclear masses.)

  19. Central pontine myelinolysis.

    Science.gov (United States)

    Kiley, M A; King, M; Burns, R J

    1999-03-01

    Central pontine myelinolysis (CPM) was initially associated with alcoholism. Subsequently other factors, including rapid reversal of hyponatraemia and extreme serum hypoosmolality associated with severe burns, have been identified as other important factors in its pathogenesis. Extra-pontine lesions have also been described. CPM may be found at autopsy, either having been overlooked during life or as an incidental finding. Its precise incidence is not known but the ability to diagnose it during life has been helped by modern neuroimaging, particularly magnetic resonance imaging (MRI) of the brain stem. In the past the prognosis for CPM was thought to be invariably fatal. It is clear now that with the greater general awareness of the disorder and the ability to diagnose it during life that some degree of recovery is possible. However, the number who do recover and the degree of recovery is not known. We report a 40-year-old man who developed CPM presenting with quadriparesis and inability to speak and swallow. There were risk factors for CPM and the diagnosis was confirmed by MRI scanning. He made a complete recovery although he remains ataxic. We are reporting this case as we believe it is important to make clinicians aware of the potential for recovery of CPM. While no specific treatment has been shown to influence the degree and rate of recovery of the demyelination, the fact that the quadriplegia and bulbar paralysis can recover fully is of considerable importance. In particular, it means that when the diagnosis is made, complete and vigorous nursing and medical care is warranted. PMID:18639140

  20. Dublin South Central (DSC)

    LENUS (Irish Health Repository)

    O'Gorman, Clodagh S M

    2010-12-01

    Children who appear healthy, even if they have one or more recognized cardiovascular risk factors, do not generally have outcomes of cardiovascular or other vascular disease during childhood. Historically, pediatric medicine has not aggressively screened for or treated cardiovascular risk factors in otherwise healthy children. However, studies such as the P-Day Study (Pathobiological Determinants of Atherosclerosis in Youth), and the Bogalusa Heart Study, indicate that healthy children at remarkably young ages can have evidence of significant atherosclerosis. With the increasing prevalence of pediatric obesity, can we expect more health problems related to the consequences of pediatric dyslipidemia, hypertriglyceridemia, and atherosclerosis in the future? For many years, medications have been available and used in adult populations to treat dyslipidemia. In recent years, reports of short-term safety of some of these medications in children have been published. However, none of these studies have detailed long-term follow-up, and therefore none have described potential late side-effects of early cholesterol-lowering therapy, or potential benefits in terms of reduction of or delay in cardiovascular or other vascular end-points. In 2007, the American Heart Association published a scientific statement on the use of cholesterol-lowering therapy in pediatric patients. In this review paper, we discuss some of the current literature on cholesterol-lowering therapy in children, including the statins that are currently available for use in children, and some of the cautions with using these and other cholesterol-lowering medications. A central tenet of this review is that medications are not a substitute for dietary and lifestyle interventions, and that even in children on cholesterol-lowering medications, physicians should take every opportunity to encourage children and their parents to make healthy diet and lifestyle choices.

  1. Central nervous system tumors

    International Nuclear Information System (INIS)

    Central nervous system (CNS) tumors are relatively common in veterinary medicine, with most diagnoses occurring in the canine and feline species. Numerous tumor types from various cells or origins have been identified with the most common tumors being meningiomas and glial cell tumors. Radiation therapy is often used as an aid to control the clinical signs associated with these neoplasms. In general, these tumors have a very low metastatic potential, such that local control offers substantial benefit. Experience in veterinary radiation oncology would indicate that many patients benefit from radiation treatment. Current practice indicates the need for computed tomography or magnetic resonance imaging studies. These highly beneficial studies are used for diagnosis, treatment planning, and to monitor treatment response. Improvements in treatment planning and radiation delivered to the tumor, while sparing the normal tissues, should improve local control and decrease potential radiation related problems to the CNS. When possible, multiple fractions of 3 Gy or less should be used. The tolerance dose to the normal tissue with this fractionation schedule is 50 to 55 Gy. The most common and serious complications of radiation for CNS tumors is delayed radiation myelopathy and necrosis. Medical management of the patient during radiation therapy requires careful attention to anesthetic protocols, and medications to reduce intracranial pressure that is often elevated in these patients. Canine brain tumors have served as an experimental model to test numerous new treatments. Increased availability of advanced imaging modalities has spawned increased detection of these neoplasms. Early detection of these tumors with appropriate aggressive therapy should prove beneficial to many patients

  2. Central bank independence and ageing

    OpenAIRE

    Farvaque, Etienne; Héricourt, Jérôme; Lagadec, Gaël

    2008-01-01

    We contrast the influence of demography and central bank independence on inflation. The recent demographic trends in developed countries are shown to weight more on inflation than central bank independence, while the contrary stands for the period from 1960 to 1979.

  3. Central dose registration in Switzerland

    International Nuclear Information System (INIS)

    In 1990 the Central Swiss Dose Register of the Federal Health Office took up its activities. The following publication describes the organisation of dosimetry applicable to persons in Switzerland together with a brief history of dose registration, the central dose register and its applications. 2 refs

  4. 多种教学方法在解热镇痛抗炎药教学中的应用%The Application of Multiple Teaching Methods in the Teach-ing of Antipyretic Analgesic and Anti-inflammatory Drugs

    Institute of Scientific and Technical Information of China (English)

    杨薪正

    2014-01-01

    药理学是一门桥梁学科,是多学科的融合。药品种类繁多、作用机制复杂、理论性强、不易理解、难记忆。本文通过比较法、图片演示法、歌诀法、教学简笔画法等教学方法在解热镇痛抗炎药教学中的应用,阐述灵活掌握教学方法对引导学生主动学习,提高药理学教学质量的重要性。%Pharmacology is a subject just like a bridge, as it is multidisciplinary integration. It includes variety of drugs, complex mechanism of drug action, and a higher theoretical level, so it is difficult in understanding and remembering. Through adopting comparison method, image presentation method, method of for-mulas and stick figure method in the teaching of antipyretic anal-gesic and anti-inflammatory drugs, it proves a view that master-ing the teaching methods flexibly plays a significant role in in-structing students' active study and improving the quality of pharmacology teaching.

  5. Material development in the SI{sub 3}N{sub 4} system using glass encapsulated Hip`ing. Final report, Phase 2: DOE/ORNL Ceramic Technology Project

    Energy Technology Data Exchange (ETDEWEB)

    Corbin, N.D.; Sundberg, G.J.; Siebein, K.N.; Willkens, C.A.; Pujari, V.K.; Rossi, G.A.; Hansen, J.S.; Chang, C.L.; Hammarstrom, J.L.

    1992-04-01

    This report covers a two-year program to develop fully dense Si{sub 3}N{sub 4} matrix SiC whisker composites with enhanced properties over monolithic Si{sub 3}N{sub 4} materials. The primary goal was to develop a composite with a fracture toughness > 10 MPa{radical}m, capable of using high pressure glass encapsulated HIP`ing. Coating methods were developed to apply thin (<150nm) stoichiometric BN layers to SiC whiskers and also to apply a dual coating of SiC over carbon to the whiskers. Fracture toughness of the composites was determined to increase as the quantity of whiskers (or elongated grains) with their axis perpendicular to the crack plane increased. Of the interface compositions evaluated in this effort, carbon was determined to be the most effective for increasing toughness. The highest toughnesses (6.8--7.0 MPa{radical}m) were obtained with uniaxially aligned carbon coated whiskers. There was no evidence of the carbon coating compromising the oxidation resistance of the composites at 1370{degree}C.

  6. Central control of body temperature.

    Science.gov (United States)

    Morrison, Shaun F

    2016-01-01

    Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis. PMID:27239289

  7. SQUARE AND RHOMBUS CENTRAL CONFIGURATIONS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In this paper, we consider the flat central configurations of bodies using the characteristic set method. We completely solve two special cases of four planets, namely,the square and the rhombus. For the square case, we obtain that a square is a central configuration only in the case where the masses are equal and there exactly are two different square central configurations determined by the mass and the angular velocity; for the rhombus case, we obtain that if a rhombus is a central configuration, then the masses of the diagonal vertices must be equal. Furthermore, there are two or three or four different rhombus central configurations determined by the masses and the angular velocity.

  8. Central control of body temperature

    Science.gov (United States)

    Morrison, Shaun F.

    2016-01-01

    Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis. PMID:27239289

  9. North Central Thailand

    Science.gov (United States)

    1998-01-01

    This radar image shows the dramatic landscape in the Phang Hoei Range of north central Thailand, about 40 kilometers (25 miles) northeast of the city of Lom Sak. The plateau, shown in green to the left of center, is the area of Phu Kradung National Park. This plateau is a remnant of a once larger plateau, another portion of which is seen along the right side of the image. The plateaus have been dissected by water erosion over thousands of years. Forest areas appear green on the image; agricultural areas and settlements appear as red and blue. North is toward the lower right. The area shown is 38 by 50 kilometers (24 by 31 miles) and is centered at 16.96 degrees north latitude, 101.67 degrees east longitude. Colors are assigned to different radar frequencies and polarizations as follows: red is L-band horizontally transmitted and horizontally received; green is L-band horizontally transmitted and vertically received; blue is C-band horizontally transmitted and vertically received. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) imaging radar on October 3, 1994, when it flew aboard the space shuttle Endeavour. SIR-C/X-SAR is a joint mission of the U.S./German and Italian space agencies.Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those changes which are induced by human activity. SIR-C was developed by NASA

  10. Betweenness centrality profiles in trees

    CERN Document Server

    Fish, Benjamin; Turan, Gyorgy

    2016-01-01

    Betweenness centrality of a vertex in a graph measures the fraction of shortest paths going through the vertex. This is a basic notion for determining the importance of a vertex in a network. The k-betweenness centrality of a vertex is defined similarly, but only considers shortest paths of length at most k. The sequence of k-betweenness centralities for all possible values of k forms the betweenness centrality profile of a vertex. We study properties of betweenness centrality profiles in trees. We show that for scale-free random trees, for fixed k, the expectation of k-betweenness centrality strictly decreases as the index of the vertex increases. We also analyze worst-case properties of profiles in terms of the distance of profiles from being monotone, and the number of times pairs of profiles can cross. This is related to whether k-betweenness centrality, for small values of k, may be used instead of having to consider all shortest paths. Bounds are given that are optimal in order of magnitude. We also pre...

  11. Central European gas market perspectives

    International Nuclear Information System (INIS)

    This presentation deals with (1) Definition of the Central European market, (2) Factors driving up consumption of natural gas in Central and Eastern Europe, (3) Role of natural gas in regional energy consumption, (4) Position of natural gas in individual country markets, (5) Future sources of imported natural gas into the region. The Central European market are the eleven countries Albania, Bulgaria, Croatia, Czech Republic, Hungary, Macedonia, Poland, Romania, Serbia and Montenegro, Slovakia, and Slovenia, with a total population of 121 million. This market is comparable to combined France and Italy in terms of population, but only 30% of its size in terms of GDP

  12. Centralized digital control of accelerators

    International Nuclear Information System (INIS)

    In contrasting the title of this paper with a second paper to be presented at this conference entitled Distributed Digital Control of Accelerators, a potential reader might be led to believe that this paper will focus on systems whose computing intelligence is centered in one or more computers in a centralized location. Instead, this paper will describe the architectural evolution of SLAC's computer based accelerator control systems with respect to the distribution of their intelligence. However, the use of the word centralized in the title is appropriate because these systems are based on the use of centralized large and computationally powerful processors that are typically supported by networks of smaller distributed processors

  13. Payments and Central Bank Policy

    DEFF Research Database (Denmark)

    Korsgaard, Søren

    This thesis consists of three chapters. The rst, "Paying for Payments", examines the role of interchange fees in payment card networks. The second, "Bank Liquidity and the Interbank Market" (co-authored with Mikael Reimer Jensen), investigates how banks' liquidity holdings at the central bank a ect...... outcomes in the money market. The third, "Collateralized Lending and Central Bank Collateral Policy", considers the emergence of credit constraints under collateralized lending, and how central banks use collateral policy to mitigate these constraints. While the chapters can be read independently, they...... share common themes. Each chapter is concerned with payments in one way or another, each is concerned with the e ciency of market outcomes, and, to the extent that there is scope for improving these outcomes, each discusses the appropriate role for policy, in particular central bank policy....

  14. Central Exclusive Production at LHCb

    CERN Document Server

    McNulty, Ronan

    2015-01-01

    Central Exclusive Production is a unique QCD process in which particles are produced via colourless propagators. Several results have been obtained at LHCb for the production of single charmonia, pairs of charmonia, and single bottomonia.

  15. The Central Trigger Processor (CTP)

    CERN Multimedia

    Franchini, Matteo

    2016-01-01

    The Central Trigger Processor (CTP) receives trigger information from the calorimeter and muon trigger processors, as well as from other sources of trigger. It makes the Level-1 decision (L1A) based on a trigger menu.

  16. Congenital nystagmus and central hypothyroidism

    OpenAIRE

    Reynaert, Nele; Braat, Elke; de Zegher, Francis

    2015-01-01

    We observed a male newborn with bilateral nystagmus and central hypothyroidism without hypoprolactinemia due to a deletion of chromosome band Xq26.1q26.2, containing FRMD7 and IGSF1. These two loss-of function mutations are known to cause, respectively, congenital nystagmus and the ensemble of central hypothyroidism, hypoprolactinemia and testicular enlargement. These latter two features may not yet be present in early life.

  17. Central Control Over Distributed Routing

    OpenAIRE

    Vissicchio, Stefano; Tilmans, Olivier; Vanbever, Laurent; Rexford, Jennifer; ACM SIGCOMM

    2015-01-01

    Centralizing routing decisions offers tremendous flexibility, but sacrifices the robustness of distributed protocols. In this paper, we present Fibbing, an architecture that achieves both flexibility and robustness through central control over distributed routing. Fibbing introduces fake nodes and links into an underlying link-state routing protocol, so that routers compute their own forwarding tables based on the augmented topology. Fibbing is expressive, and readily supports flexible load b...

  18. Rogoff's 'Conservative' Central Banker Restored

    OpenAIRE

    Herrendorf, Berthold; Lockwood, Ben

    1996-01-01

    This paper shows that delegation of monetary policy to a weight-conservative central banker is optimal, although the government can also use an inflation contract, an employment target, an inflation target, or any combination of these, to control the central banker. The key feature of our model is a stochastic inflation bias, arising when wage-setters receive some information about a supply shock prior to signing nominal wage contracts. Weight-conservatism is shown to be desirable if the stoc...

  19. CENTRAL PLATEAU REMEDIATION OPTIMIZATION STUDY

    Energy Technology Data Exchange (ETDEWEB)

    BERGMAN, T. B.; STEFANSKI, L. D.; SEELEY, P. N.; ZINSLI, L. C.; CUSACK, L. J.

    2012-09-19

    THE CENTRAL PLATEAU REMEDIATION OPTIMIZATION STUDY WAS CONDUCTED TO DEVELOP AN OPTIMAL SEQUENCE OF REMEDIATION ACTIVITIES IMPLEMENTING THE CERCLA DECISION ON THE CENTRAL PLATEAU. THE STUDY DEFINES A SEQUENCE OF ACTIVITIES THAT RESULT IN AN EFFECTIVE USE OF RESOURCES FROM A STRATEGIC PERSPECTIVE WHEN CONSIDERING EQUIPMENT PROCUREMENT AND STAGING, WORKFORCE MOBILIZATION/DEMOBILIZATION, WORKFORCE LEVELING, WORKFORCE SKILL-MIX, AND OTHER REMEDIATION/DISPOSITION PROJECT EXECUTION PARAMETERS.

  20. Re-Centring Central Asia

    OpenAIRE

    Grenet, Frantz

    2015-01-01

    The “golden peaches” of Samarkand in the days of Sogdian trade As a cultural area Central Asia was recognized at a late stage, since its emergence as a geographical reality was very slow. The term Central Asia was coined in around 1825, simultaneously in Russia and in France, by the diplomat Georges de Meyendorff and by Julius Klaproth, respectively. It soon gained currency, along with its variant Middle Asia, sometimes preferred in Russia. Reading this nineteenth-century geographic literat...

  1. Audit Committees in Central Banks

    OpenAIRE

    Kenneth Sullivan; Marie-Therese Camilleri; Tonny Lybek

    2007-01-01

    This paper reviews the tasks and design of audit committees, increasingly recommended as a way to strengthen financial accountability and good central bank governance. It outlines the motivations for the establishment of audit committees in commercial corporations and public sector entities, and explains how audit committees interact with other governance bodies within a central bank. The paper focuses on the functions of an audit committee, since the terminology of the governance structure i...

  2. Discussion on the construction of MOOC course in obstetric and gynecological nursing teach-ing%妇产科护理学课程慕课建设探讨

    Institute of Scientific and Technical Information of China (English)

    廖碧珍

    2015-01-01

    重庆医科大学为适应信息化教学新要求,以培养具有良好评判思维能力及岗位胜任力的新型护理人才为目标,以课程建设为突破口,探索妇产科护理学课程慕课建设与应用。通过慕课网络平台为学生提供丰富教学资源,让学生课前完成自主学习、互动讨论、试题出错率检测与反馈,为教师设计翻转课堂教学提供依据。利用慕课实施混合教学,逐步培养学生自主学习能力。%To meet the new requirements of modern information education, and to achieve the goal of developing a new type of nursing talents with good judgment thinking ability and post compe-tency, Chongqing Medical University explored the construction and application of nursing courses in obstetrics and Gynecology. By means of MOOC network platform, we provided students with rich teach-ing resources, so that students could complete their own learning, interactive discussion, examination questions and feedback, to provide the basis for teachers designing the teaching of flipped classroom. We also used the MOOC class to implement the mixed teaching, and gradually develop students' au-tonomous learning ability.

  3. Eesti lastekodulaps kinkis Norra kuningannale ingli

    Index Scriptorium Estoniae

    2004-01-01

    Norra kuninganna Sonja ning peaminister Kjell Magne Bondevik võõrustasid lastekodukasvandikku Marina Shirabokovat koos Norra filantroobi Solveig Bergslandiga, kes on seitse aastat toetanud puudust kannatavaid Eesti lapsi

  4. "-ing" Project: Encouraging Cohesion in Small Groups

    Science.gov (United States)

    McBride, M. Chad

    2006-01-01

    Group cohesiveness is a topic addressed in most small group communication texts and courses and is often defined as the degree of attraction members feel towards one another, the degree of loyalty within a group, or the "groupness" felt among members. Further, groups which are cohesive tend to be happier and more productive. When working on…

  5. Idea juht eitas maksupettust / Inge Rumessen

    Index Scriptorium Estoniae

    Rumessen, Inge

    2002-01-01

    Reklaamiagentuuri Idea juht Mark Eikner eitas kohtuistungil seost mitmemiljonilise maksupettuse skeemiga möödunud kohalike valimiste ajal. Kohtuprotsess Meelis Siidirätsepa üle, kes OÜ Rescue juhina jättis tasumata 1,5 milj. krooni käibemaksu

  6. DAM-ing the Digital Flood

    Science.gov (United States)

    Raths, David

    2008-01-01

    With the widespread digitization of art, photography, and music, plus the introduction of streaming video, many colleges and universities are realizing that they must develop or purchase systems to preserve their school's digitized objects; that they must create searchable databases so that researchers can find and share copies of digital files;…

  7. Zinc'ing down RNA polymerase I

    OpenAIRE

    Chanfreau, Guillaume F.

    2013-01-01

    Most RNA polymerases contain zinc, yet the precise function of zinc and its influence of polymerases stability are unknown. A recent study provides evidence that zinc levels control the stability of RNA polymerase I in vivo and that the enzyme might serve as a zinc reservoir for other proteins.

  8. Ühiskonnakriitika kinos / Inge Pitsner

    Index Scriptorium Estoniae

    Pitsner, Inge

    2004-01-01

    Baltimaade dokfilmiprogramm "Subjektiivne kaamera", mis tutvustab uuemaid provokatiivseid, poleemikat tekitavaid autorikeskseid filme. See on osa Tallinnas toimuvast 8. Läänemere Dokumentalistika Foorumist

  9. Lögleiðing kannabisefna

    OpenAIRE

    Sigurður Magnús Sigurðsson 1985

    2012-01-01

    Þessi ritgerð eða rannsókn fjallar um hvort lögleiðsla kannabisefna á Íslandi muni hafa neikvæð eða jákvæð áhrif fyrir samfélagið. Í aldanna rás hefur mannkynið haft mikla reynslu af kannabis/marijúana plöntunni og afurðum hennar. Kannabisefni birtast okkur í ýmsu formi, svo sem í fatnaði, byggingavörum og jafnvel í matvælum, en stærsta ágreiningsefnið hvað kannabis varðar er hampurinn sem marijúana plantan framleiðir. Manneskjur geta reykt, borðað eða drukkið þessa afurð plöntunnar með...

  10. Ravimid, risk, raha & tervis / Inge Pitsner

    Index Scriptorium Estoniae

    Pitsner, Inge

    2008-01-01

    Ravimifirma Roche Eesti OÜ tegevjuht Kadri Mägi selgitab ravimiäri toimemehhanisme ning põhjuseid, miks ravimitööstus on riskantne ja kallis valdkond. Lisa: Mis on farmakoökonoomika?; Roche Eesti kontor

  11. Pharmaceutical Market(ing): Theory and Reality

    OpenAIRE

    Stevan Vasiljev; Darko Pantelic

    2010-01-01

    The pharmaceutical market represents one of the most dynamic and controversial markets. Its specific features are rooted in the specific nature of its products and in the complex interests of the main constituents of market demand. Finding ways to improve marketing practice in the pharmaceutical sector lie in understanding marketing theory and best practice logic and comparing it with on-going everyday practice. Sensitive circumstances of using pharmaceuticals, their potential for abuse and h...

  12. All aboard the Safety Train(ing)!

    CERN Multimedia

    Rosaria Marraffino

    2015-01-01

    Would you like to influence CERN’s safety courses? Do you want to help build better training courses? If your answer is yes to one or both of these questions: now is the time! The Safety Training section is looking for volunteers from the whole CERN community to test new courses before they go online for all members of the personnel.    The Safety Training section is redesigning the CERN e-learning package in order to adopt a more educational approach and to make the courses a more enjoyable experience. The section is now calling for volunteers. “We know we can do much more with testers’ help and feedback,” explains Christoph Balle, Safety Training section leader. “By having the end users actively involved in the process, we’ll achieve our goal of communicating safety in the best possible way. As the volunteers will play an active role in the development of the courses, they will be providing a service to the whole community.&am...

  13. Tenor bass, dr02, Central Symphony

    OpenAIRE

    Helmlinger, Aurélie

    2011-01-01

    Tenor bass, dr02, augmented, Central Symphony Steel Orchestra panyard, Government House road, Tobago( erreur dans le nom de fichier : "central_symphony_steel_tenor_bass_1_dr02" ; nom correct ="central_symphony_tenor_bass_1_dr02 " )

  14. Ash Layers: The Controlling Factor On Translational Sliding Offshore Central America?

    Science.gov (United States)

    Harders, R.; Brueckmann, W.; Feeser, V.; Hensen, C.; Kutterolf, S.

    2006-12-01

    The erosive convergent margin of Central America is dominated by the fast subduction of the rough Pacific plate. Off Costa Rica the morphology of the subducted oceanic plate is characterized by numerous seamounts and the Cocos Ridge. Off Nicaragua fewer seamounts and bend ing-related faults dominate the morphology. In both areas seamount subduction with resulting slope uplift or subduction erosion at the base of the upper plate causes oversteepening and frequent slope failure. Our investigation focuses on translational slides off Nicaragua (Skempton ratio pelagic sediments. Firstly they have higher contents of silt and sand causing higher intrinsic permeabilities. Secondly they consist of disc shaped glass shards which causes higher consolidation rates. This is proved by our first laboratory shear box tests, where ash matter compacted with much higher values than spherical grain shaped reference material of the same grain size. Both factors together could cause a peak pore pressure if ashes compacted rapidly, for instance in a seismic event like the earthquake 1992 off Nicaragua. This would effectively reduce the shear strength between the ash particles and facilitate translational failure. To test this hypothesis and to analyse the relation between pore water pressures and shear strengths under drained conditions, we have modified a shear box, to simultaneously measure pore water pressure and shear strength. We will present field observations from cruise M66 as well as first results from laboratory deformation experiments, supporting our model.

  15. Ocorrência e aspectos ecológicos de metazoários parasitos de peixes do Lago do Parque do Ingá, Maringá, Estado do Paraná - DOI: 10.4025/actascibiolsci.v29i3.507 Occurrence and ecological aspects of the metazoan fish parasites from Ingá lake, Maringá, Paraná State - DOI: 10.4025/actascibiolsci.v29i3.507

    Directory of Open Access Journals (Sweden)

    Marion Haruko Machado

    2007-12-01

    Full Text Available Nenhum estudo de peixes e parasitos foi realizado, até o momento, no Lago do Parque do Ingá que sofre influências antrópicas desde seu represamento, em 1970. Este trabalho analisou alguns aspectos ecológicos dos parasitos metazoários dos peixes deste lago. Dos peixes analisados, (69,5% estavam parasitados por pelo menos uma espécie de parasito. Foram encontrados 1.372 parasitos pertencentes à Nematoda (larvas e Platyhelminthes (Monogenea e Cestoda, sendo estes os mais prevalentes e numerosos. O encontro de larvas de cestóides em Tilapia rendalli e Oreochromis niloticus confirma a importância destas espécies como participantes de níveis tróficos intermediários. A maior abundância de T. rendalli e O. niloticus, no local, pode ser um fator determinante no recrutamento de parasitos. O parasito aproveita-se das espécies de hospedeiros mais abundantes para garantir o desenvolvimento de seu ciclo de vida e também por serem os mais disponíveis à predação pelas aves piscívoras ali presentes, o que torna o local de grande importância para a sustentação do ciclo de vida desses parasitos. A baixa diversidade de endoparasitos coletados pode ser justificada pela presença de metais pesados – Cu e Pb – no sedimento, o que deve estar interferindo no desenvolvimento dos invertebrados, possíveis hospedeiros intermediários.Ingá lake was dammed in 1970 and, since then, no study on fish and parasites had been done, but it has suffered anthropic influences. This study analyzed some ecological aspects of the metazoan parasites form this lake. From analyzed fish, 69.5% had at least one species of parasite. Among them, 1.372 parasites were found, prevailing Nematoda (larvae and Platyhelminthes (Monogenea and Cestoda. The discovery of cestode larvae in Tilapia rendalli and Oreochromis nitolicus confirms the importance of these species as participants of intermediate trophic levels. The great number of Tilapia rendalli and Oreochromis

  16. Network centrality of metro systems.

    Directory of Open Access Journals (Sweden)

    Sybil Derrible

    Full Text Available Whilst being hailed as the remedy to the world's ills, cities will need to adapt in the 21(st century. In particular, the role of public transport is likely to increase significantly, and new methods and technics to better plan transit systems are in dire need. This paper examines one fundamental aspect of transit: network centrality. By applying the notion of betweenness centrality to 28 worldwide metro systems, the main goal of this paper is to study the emergence of global trends in the evolution of centrality with network size and examine several individual systems in more detail. Betweenness was notably found to consistently become more evenly distributed with size (i.e. no "winner takes all" unlike other complex network properties. Two distinct regimes were also observed that are representative of their structure. Moreover, the share of betweenness was found to decrease in a power law with size (with exponent 1 for the average node, but the share of most central nodes decreases much slower than least central nodes (0.87 vs. 2.48. Finally the betweenness of individual stations in several systems were examined, which can be useful to locate stations where passengers can be redistributed to relieve pressure from overcrowded stations. Overall, this study offers significant insights that can help planners in their task to design the systems of tomorrow, and similar undertakings can easily be imagined to other urban infrastructure systems (e.g., electricity grid, water/wastewater system, etc. to develop more sustainable cities.

  17. Network centrality of metro systems.

    Science.gov (United States)

    Derrible, Sybil

    2012-01-01

    Whilst being hailed as the remedy to the world's ills, cities will need to adapt in the 21(st) century. In particular, the role of public transport is likely to increase significantly, and new methods and technics to better plan transit systems are in dire need. This paper examines one fundamental aspect of transit: network centrality. By applying the notion of betweenness centrality to 28 worldwide metro systems, the main goal of this paper is to study the emergence of global trends in the evolution of centrality with network size and examine several individual systems in more detail. Betweenness was notably found to consistently become more evenly distributed with size (i.e. no "winner takes all") unlike other complex network properties. Two distinct regimes were also observed that are representative of their structure. Moreover, the share of betweenness was found to decrease in a power law with size (with exponent 1 for the average node), but the share of most central nodes decreases much slower than least central nodes (0.87 vs. 2.48). Finally the betweenness of individual stations in several systems were examined, which can be useful to locate stations where passengers can be redistributed to relieve pressure from overcrowded stations. Overall, this study offers significant insights that can help planners in their task to design the systems of tomorrow, and similar undertakings can easily be imagined to other urban infrastructure systems (e.g., electricity grid, water/wastewater system, etc.) to develop more sustainable cities. PMID:22792373

  18. Coverage centralities for temporal networks*

    Science.gov (United States)

    Takaguchi, Taro; Yano, Yosuke; Yoshida, Yuichi

    2016-02-01

    Structure of real networked systems, such as social relationship, can be modeled as temporal networks in which each edge appears only at the prescribed time. Understanding the structure of temporal networks requires quantifying the importance of a temporal vertex, which is a pair of vertex index and time. In this paper, we define two centrality measures of a temporal vertex based on the fastest temporal paths which use the temporal vertex. The definition is free from parameters and robust against the change in time scale on which we focus. In addition, we can efficiently compute these centrality values for all temporal vertices. Using the two centrality measures, we reveal that distributions of these centrality values of real-world temporal networks are heterogeneous. For various datasets, we also demonstrate that a majority of the highly central temporal vertices are located within a narrow time window around a particular time. In other words, there is a bottleneck time at which most information sent in the temporal network passes through a small number of temporal vertices, which suggests an important role of these temporal vertices in spreading phenomena. Contribution to the Topical Issue "Temporal Network Theory and Applications", edited by Petter Holme.Supplementary material in the form of one pdf file available from the Journal web page at http://dx.doi.org/10.1140/epjb/e2016-60498-7

  19. Coverage centralities for temporal networks

    CERN Document Server

    Takaguchi, Taro; Yoshida, Yuichi

    2015-01-01

    Structure of real networked systems, such as social relationship, can be modeled as temporal networks in which each edge appears only at the prescribed time. Understanding the structure of temporal networks requires quantifying the importance of a temporal vertex, which is a pair of vertex index and time. In this paper, we define two centrality measures of a temporal vertex by the proportion of (normal) vertex pairs, the quickest routes between which can (or should) use the temporal vertex. The definition is free from parameters and robust against the change in time scale on which we focus. In addition, we can efficiently compute these centrality values for all temporal vertices. Using the two centrality measures, we reveal that distributions of these centrality values of real-world temporal networks are heterogeneous. For various datasets, we also demonstrate that a majority of the highly central temporal vertices are located within a narrow time window around a particular time. In other words, there is a bo...

  20. Centralized digital control of accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Melen, R.E.

    1983-09-01

    In contrasting the title of this paper with a second paper to be presented at this conference entitled Distributed Digital Control of Accelerators, a potential reader might be led to believe that this paper will focus on systems whose computing intelligence is centered in one or more computers in a centralized location. Instead, this paper will describe the architectural evolution of SLAC's computer based accelerator control systems with respect to the distribution of their intelligence. However, the use of the word centralized in the title is appropriate because these systems are based on the use of centralized large and computationally powerful processors that are typically supported by networks of smaller distributed processors.

  1. Pathophysiology of central sleep apneas.

    Science.gov (United States)

    Hernandez, Adam B; Patil, Susheel P

    2016-05-01

    The transition from wake to sleep is accompanied by a host of physiologic changes, which result in major alterations in respiratory control and may result in sleep-related breathing disorders. The central sleep apneas are a group of sleep-related breathing disorders that are characterized by recurrent episodes of airflow reduction or cessation due to a temporary reduction or absence of central respiratory drive. The fundamental hallmark of central sleep apnea (CSA) disorders is the presence of ventilatory control instability; however, additional mechanisms play a role in one or more specific manifestations of CSA. CSA may manifest during conditions of eucapnia/hypocapnia or chronic hypercapnia, which is a useful clinical classification that lends understanding to the underlying pathophysiology and potential therapies. In this review, an overview of normal breathing physiology is provided, followed by a discussion of pathophysiologic mechanisms that promote CSA and the mechanisms that are specific to different manifestations of CSA. PMID:26782104

  2. Network Centrality of Metro Systems

    OpenAIRE

    Sybil Derrible

    2012-01-01

    Whilst being hailed as the remedy to the world's ills, cities will need to adapt in the 21(st) century. In particular, the role of public transport is likely to increase significantly, and new methods and technics to better plan transit systems are in dire need. This paper examines one fundamental aspect of transit: network centrality. By applying the notion of betweenness centrality to 28 worldwide metro systems, the main goal of this paper is to study the emergence of global trends in the e...

  3. From Dungans to Xinyimin: China, Chinese Migration and the Changing Sociopolitical Fabric of Central Asian Republics

    Directory of Open Access Journals (Sweden)

    Emile Kok-Kheng Yeoh

    2015-08-01

    Full Text Available This paper looks at the issue of ethnic identity of the Dungans – descendants of early Chinese migrants in Central Asia – and its change and preservation in the context of the fragile social fabric of the Central Asian states that were born from the shadow of the now-defunct Soviet Union, the arduous processes of nation-building plagued by often violent, competing emergent nationalisms as well as political and economic turbulence, and the impact brought by the emergence of the xinyimin (Chinese new migrants. These Chinese-speaking Dungans staying in compact communities mostly in Kazakhstan, Kyrgyzstan and Uzbekistan are descendants of political and war refugees from China’s provinces of Shaanxi and Gansu who moved across the border into the territory of Czarist Russia in the later part of the nineteenth century after the crushing of the Northwest Uprising by the Imperial Ch’ing (the Manchu dynasty army which bordered on genocide and ethnic cleansing. This paper analyses how a new ethnic identity has since emerged due partly to the geographical isolation imposed by the formidable natural barrier of the Tianshan (“Heavenly Mountains” However, their Chinese language in the form of a mixture of the Shaanxi and Gansu regionalects, remarkably written today not in Chinese characters but in the Cyrillic alphabet, and Chinese traditions of the Shaanxi and Gansu varieties have been fiercely preserved through the generations until today, including nineteenth-century vocabulary and traditions which are no longer found in modern China, due both to the cohesiveness of communal life and an aversion to marriage outside the community. After analysing the community’s dilemmas of identity preservation and identity creation, this paper then proceeds to look at the impact of the disintegration of the Soviet Union in 1991 resulting in the birth of the post-Soviet independent Central Asian republics, and the influx of the xinyimin from China since the

  4. Copycats of the Central Himalayas

    NARCIS (Netherlands)

    P.A. Arora (Payal)

    2009-01-01

    textabstractThis case study highlights practices of a rarely documented group of neo-users of the Internet or newbies from Central Himalayas, serving as a catalyst for delving deeply into the act of ‘plagiarism’ in online learning By looking at such ‘learning’ practices away from schools, namely at

  5. /S/ in Central American Spanish.

    Science.gov (United States)

    Lipski, John M.

    1985-01-01

    Describes the behavior of the phoneme /s/ in Central American Spanish by comparing the speech patterns of residents of Guatemala City, San Salvador, Tegucigalpa, San Jose, and Managua. Considers the possible diachronic processes which could have given rise to the current configurations and the theoretical consequences implied by the…

  6. The CMS central hadron calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, J.; E892 Collaboration

    1996-12-31

    The CMS central hadron calorimeter is a copper absorber/ scintillator sampling structure. We describe design choices that led us to this concept, details of the mechanical and optical structure, and test beam results. We discuss calibration techniques, and finally the anticipated construction schedule.

  7. A First for Central America

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    FTA gives impetus to China’s trade with Costa Rica and other countries in the region The free trade agreement (FTA) between China and Costa Rica, signed in April 2010,came into effect on August 1.It was the first free trade pact between China and a Central

  8. Vulnerability in north- central Vietnam

    DEFF Research Database (Denmark)

    Casse, Thorkil; Milhøj, Anders; Nguyen, Thao Phuong

    2015-01-01

    This article examines changes in livelihood strategies in response to flooding. It does so on the basis of a household survey which was undertaken in three provinces in north central Vietnam. All households in the survey were regularly affected by flooding, but only poor households experience...

  9. Illustrating the Central Limit Theorem

    Science.gov (United States)

    Corcoran, Mimi

    2016-01-01

    Statistics is enjoying some well-deserved limelight across mathematics curricula of late. Some statistical concepts, however, are not especially intuitive, and students struggle to comprehend and apply them. As an AP Statistics teacher, the author appreciates the central limit theorem as a foundational concept that plays a crucial role in…

  10. Centralized Allocation in Multiple Markets

    DEFF Research Database (Denmark)

    Monte, Daniel; Tumennasan, Norovsambuu

    | generalizations of Gale's Top Trading Cycles mechanism. We study the centralized allocation that takes place in multiple markets. For example, the assignment of multiple types of indivisible objects; or the assignment of objects in successive periods. We show that the set of strategy-proof, Pareto efficient and...

  11. Large teleseismic P-wave residuals observed at the Alban Hills volcano, Central Italy

    Directory of Open Access Journals (Sweden)

    H. Mahadeva Iyer

    1994-06-01

    Full Text Available We collected teleseismic waveforms from a digital microseismic network deployed by the Istituto Nazionale di Geofisica (ING in collaboration with the U.S. Geological Survey (USGS, on the Alban Hills Quaternary volcano during the 1989-1990 seismic swann. About 50 events were recorded by the network, 30 of them by at least 4 stations. We analysed the data in order to image crustal heterogeneities beneath the volcano. The results show large delay time residuals up to - 1 second for stations located on the volcano with respect to station CP9 of the National Seismic Network located about 20 km to the east, on the Apennines. This suggests that the whole area overlies a broad low-velocity region. Although the ray coverage is not very dense, we model the gross seismic structure beneath the volcano by inverting the teleseismic relative residuals with the ACH technique. The main features detected by tbc inversion are a low-velocity zone beneath the southwestern fiank of tbc volcano, and a high-velocity region beneath the center. The depth extension of these anomalous zones ranges between 5 and 16 km. The correspondence between the low-velocity region and the most recent activity of the volcano (- 0.027 Ma leads us to infer the presence of a still hot magmatic body in the crust beneath the southwestern side of the volcano, whereas the central part overlies the older and colder high-velocity volcanic roots related to the previous central activity (0.7 to 0.3 Ma.

  12. From Centrality to Temporary Fame: Dynamic Centrality in Complex Networks

    OpenAIRE

    Braha, Dan; Bar-Yam, Yaneer

    2006-01-01

    We develop a new approach to the study of the dynamics of link utilization in complex networks using records of communication in a large social network. Counter to the perspective that nodes have particular roles, we find roles change dramatically from day to day. "Local hubs" have a power law degree distribution over time, with no characteristic degree value. Our results imply a significant reinterpretation of the concept of node centrality in complex networks, and among other conclusions su...

  13. Centralized versus Decentralized Infrastructure Networks

    CERN Document Server

    Hines, Paul D H; Schläpfer, Markus

    2015-01-01

    While many large infrastructure networks, such as power, water, and natural gas systems, have similar physical properties governing flows, these systems tend to have distinctly different sizes and topological structures. This paper seeks to understand how these different size-scales and topological features can emerge from relatively simple design principles. Specifically, we seek to describe the conditions under which it is optimal to build decentralized network infrastructures, such as a microgrid, rather than centralized ones, such as a large high-voltage power system. While our method is simple it is useful in explaining why sometimes, but not always, it is economical to build large, interconnected networks and in other cases it is preferable to use smaller, distributed systems. The results indicate that there is not a single set of infrastructure cost conditions under which optimally-designed networks will have highly centralized architectures. Instead, as costs increase we find that average network size...

  14. A centralized audio presentation manager

    Energy Technology Data Exchange (ETDEWEB)

    Papp, A.L. III; Blattner, M.M.

    1994-05-16

    The centralized audio presentation manager addresses the problems which occur when multiple programs running simultaneously attempt to use the audio output of a computer system. Time dependence of sound means that certain auditory messages must be scheduled simultaneously, which can lead to perceptual problems due to psychoacoustic phenomena. Furthermore, the combination of speech and nonspeech audio is examined; each presents its own problems of perceptibility in an acoustic environment composed of multiple auditory streams. The centralized audio presentation manager receives abstract parameterized message requests from the currently running programs, and attempts to create and present a sonic representation in the most perceptible manner through the use of a theoretically and empirically designed rule set.

  15. Centrality in Interconnected Multilayer Networks

    CERN Document Server

    De Domenico, Manlio; Omodei, Elisa; Gómez, Sergio; Arenas, Alex

    2013-01-01

    Real-world complex systems exhibit multiple levels of relationships. In many cases, they require to be modeled by interconnected multilayer networks, characterizing interactions on several levels simultaneously. It is of crucial importance in many fields, from economics to biology, from urban planning to social sciences, to identify the most (or the less) influent nodes in a network. However, defining the centrality of actors in an interconnected structure is not trivial. In this paper, we capitalize on the tensorial formalism, recently proposed to characterize and investigate this kind of complex topologies, to show how several centrality measures -- well-known in the case of standard ("monoplex") networks -- can be extended naturally to the realm of interconnected multiplexes. We consider diagnostics widely used in different fields, e.g., computer science, biology, communication and social sciences, to cite only some of them. We show, both theoretically and numerically, that using the weighted monoplex obta...

  16. PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

    Directory of Open Access Journals (Sweden)

    S.S. Anvari

    2009-08-01

    Full Text Available ObjectivePrimary central nervous system lymphoma (PCNSL is an extremely rare condition in childhood. We report the first case of PCNSL in a child in Iran.Clinical presentationA nine-year-old boy was referred to Mofid Hospital with the history of headache of four months and seizure of 2 months duration. Magnetic resonance imaging of the brain revealed a hyper-intense lesion in left fronto-parietal area with secondary satellite lesions. Biopsy of the brain mass was performed. Pathologic findings showed brain lymphoma and immunohistochemistry confirmed this diagnosis. The treatment started with intrathecal and systemic chemotherapy in combination with radiotherapy.Keywords:Lymphoma, Primary central nervous system lymphoma (PCNSL, Children

  17. A Randomized Central Limit Theorem

    Science.gov (United States)

    Eliazar, Iddo; Klafter, Joseph

    2010-05-01

    The Central Limit Theorem (CLT), one of the most elemental pillars of Probability Theory and Statistical Physics, asserts that: the universal probability law of large aggregates of independent and identically distributed random summands with zero mean and finite variance, scaled by the square root of the aggregate-size (√{n}), is Gaussian. The scaling scheme of the CLT is deterministic and uniform - scaling all aggregate-summands by the common and deterministic factor √{n}. This Letter considers scaling schemes which are stochastic and non-uniform, and presents a "Randomized Central Limit Theorem" (RCLT): we establish a class of random scaling schemes which yields universal probability laws of large aggregates of independent and identically distributed random summands. The RCLT universal probability laws, in turn, are the one-sided and the symmetric Lévy laws.

  18. A Randomized Central Limit Theorem

    International Nuclear Information System (INIS)

    The Central Limit Theorem (CLT), one of the most elemental pillars of Probability Theory and Statistical Physics, asserts that: the universal probability law of large aggregates of independent and identically distributed random summands with zero mean and finite variance, scaled by the square root of the aggregate-size (√(n)), is Gaussian. The scaling scheme of the CLT is deterministic and uniform - scaling all aggregate-summands by the common and deterministic factor √(n). This Letter considers scaling schemes which are stochastic and non-uniform, and presents a 'Randomized Central Limit Theorem' (RCLT): we establish a class of random scaling schemes which yields universal probability laws of large aggregates of independent and identically distributed random summands. The RCLT universal probability laws, in turn, are the one-sided and the symmetric Levy laws.

  19. Central exclusive production at RHIC

    Science.gov (United States)

    Adamczyk, Leszek; Guryn, Włodek; Turnau, Jacek

    2014-11-01

    The present status and future plans of the physics program of Central Exclusive Production (CEP) at RHIC are described. The measurements are based on the detection of the forward protons from the Double Pomeron Exchange (DPE) process in the Roman Pot system and of the recoil system of charged particles from the DPE process measured in the STAR experiment's Time Projection Chamber (TPC). The data described here were taken using polarized proton-proton collisions at √ {s} = 200 GeV. The preliminary spectra of two-pion mass reconstructed by STAR TPC in central region of pseudorapidity |η| < 1, are presented. Near future plans to take data with the current system at center-of-mass energy √ {s} = 200 GeV and plans to upgrade the forward proton tagging system are presented. Also a possible addition of the RPs to the sPHENIX detector is discussed.

  20. Information from the central stores

    CERN Multimedia

    GS Department

    2010-01-01

    All items sold in the CERN shop (Bldg. 33) are now available in the central stores (Bldg. 73) and can be purchased on-line via EDH “Material Request” or at the “Emergency Desk” of the stores on the ground floor of Bldg. 73. These items are visible in the CERN catalogue under the “SCEM” codes beginning with 92. Department of General Infrastructure Services (GS) GS-SEM Group

  1. Central Asian drug trafficking dilemma

    OpenAIRE

    McGowen, Richard S.

    2003-01-01

    Tajikistan, a state that is completely landlocked, consists of very rough terrain that is comprised of mountains, cliffs and glaciers. There are very few transportation links through the area that gives Tajikistan limited access to neighboring countries. Security problems resulting from the increasing flow of narcotics illegally smuggled across the 1200 km Tajikistan- Afghanistan border have become critical in understanding the nature of political instability within Central Asia. This thesis ...

  2. Four Central Points About Coevolution

    OpenAIRE

    Thompson, John N.

    2010-01-01

    Much of evolution is about the coevolution of species with each other. In recent years, we have learned that coevolution is much more pervasive, dynamic, and relentless than we previously thought. There are four central points about coevolution that we should teach the next generation of students to help them understand the importance of the coevolutionary process in shaping the web of life. (1) Complex organisms require coevolved interactions to survive and reproduce. (2) Species-rich ecosys...

  3. CENTRAL ASIA: ECONOMIC COOPERATION POTENTIAL

    OpenAIRE

    Rakhmatullina, Gulnur

    2007-01-01

    The Central Asian republics are rich in energy resources: three of them (Kazakhstan, Uzbekistan, and Turkmenistan) can boast of oil and gas deposits, while the other two (Kyrgyzstan and Tajikistan) have vast hydropower potential. This means that harmonized energy policy designed to meet their demands in energy, energy exports, and stronger positions in ensuring international energy security makes sense. By the same token, these countries can, potentially, develop metallurgy, machine building,...

  4. Central collisions of heavy ions

    International Nuclear Information System (INIS)

    This report describes the activities of the Heavy Ion Physics Group at the University of California, Riverside from October 1, 1991 to September 30, 1992. During this period, the program focused on particle production at AGS energies, and correlation studies at the Bevalac in nucleus-nucleus central collisions. As part of the PHENIX collaboration, contributions were made to the Preliminary Conceptual Design Report (pCDR), and work on a RHIC silicon microstrip detector R ampersand D project was performed

  5. Plague in Central Java, Indonesia

    OpenAIRE

    Williams, J.E.; Hudson, B. W.; Turner, R W; Saroso, J. Sulianti; Cavanaugh, D. C.

    1980-01-01

    Plague in man occurred from 1968 to 1970 in mountain villages of the Boyolali Regency in Central Java. Infected fleas, infected rats, and seropositive rats were collected in villages with human plague cases. Subsequent isolations of Yersinia pestis and seropositive rodents, detected during investigations of rodent plague undertaken by the Government of Indonesia and the WHO, attested to the persistence of plague in the region from 1972 to 1974.

  6. MR findings of central nerocytoma

    International Nuclear Information System (INIS)

    Central neurocytoma is a reae neuronal differentiated intraventricular tomor of young adults. The purpose of this study was to evaluate the characteristic MR appearance of central neurocytoma. We retrospectively reviewed MR images of 12 patients with central neurocytoma, confirmed by ultrastructural and immunohistochemical study. We analyzed patient age, and on all sequences, tumor location, extension into the third ventricle, involvement of brain parenchyma, cyst, hemorrhage, vascular signal void and signal intensity ; and egree of Gd-enhancement was examined on MR images, pattern of calcification on CT, and neovascularity, tumor staining on angiography. Age distribution was wide ranging from 26 to 64 years ; the most frequent age group was the fourth decade (five patients). All tumors except one (in the third ventricle) were located in the lateral ventricle and most were seen in the region of the foramen of Monro (10 cases). Tumors showed extension into the third ventricle and involvement of parenchyma in three cases. The internal architecture of the tumor was heterogenous and consisted of cysts (83%), hemorrhage (25%) and vascular signal void (25%). The solid portion of the tumor showed variable signal intensity on T1-weighted images and iso or high signal intensity on T2- and proton density-weighted images. On MR imaging, mild to moderate heterogenous Gd-enhancement was seen in ten cases (83%), and on CT, a spotted, amorphous, nodular pattern of calcifications was seen in seven cases (63%). On angiography, neovasevlarity and tumor staining was seen in three cases (100%). The typical location of the lateral and third ventricles and MR imaging characteristics including variable signal intensity and heterogenous internal architecture are helpful in the diagnosis of central neurocytoma in young adults

  7. Seismotectonic model of Central Europe

    International Nuclear Information System (INIS)

    Earthquakes belong to natural disasters which are associated with tectonic processes in the interior of the Earth. They are extremely devastating in populated areas; they cause human losses and damage personal estates and the environment. To mitigate the potential effects of earthquakes it is necessary that relief and mitigation structures operate following an earthquake, but it is also essential to stimulate and enhance preparedness and prevention. Prevention includes the development of scenarios of potential earthquakes, hazard mapping, formulation of regulations, etc. Preparedness includes the installation and operation of warning systems, establishing communication networks to operate before, during, and after earthquakes. As nuclear technology belongs to high-risk technologies with regard to human health and the environment and its hazard substantially increases in consequence of earthquakes, in the siting of a nuclear plant engineering solutions are generally available to mitigate the potential vibratory effects through design. For the choice of a suitable engineering solution, reliable data must be processed by reliable techniques. The IAEA safety guide of the safety series No. 50-SG-S1(Rev. 1) specifies the demands on data and on their processing and also on the regional seismotectonic model. With a view of this the regional seismotectonic model of Central Europe was created. The paper presents regional geological characteristics of Central Europe and a chronological model of neotectonic movements in Central Europe with specification of neotectonic regional units and their present movements. Moreover, it contains earthquake characteristics for Central Europe and the specification of seismogenic movements. It was found that the genesis of local regions with occurrence of the strongest earthquakes is connected with several movement trends in the last 5 Ma. Six more or less tectonically separate regional units were revealed. The earthquake epicenters often

  8. Political centralization and government accountability

    OpenAIRE

    Boffa, Federico; Piolatto, Amedeo; Giacomo A. M. Ponzetto

    2011-01-01

    This paper explains why decentralization can undermine accountability and answers three questions: what determines if power should be centralized or decentralized when regions are heterogeneous? How many levels of government should there be? How should state borders be drawn? We develop a model of political agency in which voters differ in their ability to monitor rent-seeking politicians. We find that rent extraction is a decreasing and convex function of the share of informed...

  9. Optimal Central Counterparty Risk Management

    OpenAIRE

    Philipp Haene; Andy Sturm

    2009-01-01

    In order to protect themselves against the potential losses in case of a participant's default and to contain systemic risk, central counterparties (CCPs) need to maintain sufficient financial resources. Typically, these financial resources consist of margin requirements and contributions to a collective default fund. Based on a stylized model of CCP risk management, this article analyzes the main factors affecting the trade-off between margins and default fund. The optimal balance between th...

  10. Wine markets in central Europe

    OpenAIRE

    Š BOJNEC

    2013-01-01

    This paper analyses the tendencies of grapes growing, wine trading and wine price competitiveness in Central European region. Croatia is net exporter of wines, Hungary is net exporter of grapes and wines, and Austria, Slovakia, and Slovenia are net importers of grapes and wines. Reductions in vineyards and increase in yields are found for Austria, Hungary, and Slovakia. More stable developments in vineyards, but decline in yields, are found for Croatia and Slovenia. Grape production increases...

  11. Central nervous system mesenchymal chondrosarcoma

    International Nuclear Information System (INIS)

    Central nervous system mesenchymal chondrosarcomas are rare malignant tumors that constitute a separate entity from the classical chondrosarcoma and myxoid variant. Clinical behaviour of central nervous system chondrosarcomas is still unknown. We describe two rare examples of intracranial mesenchymal chondrosarcoma with a review of the literature, in an attempt to clarify the clinical characteristics, prognosis and treatment of choice of these unusual tumors. Among the 55 reported cases, 23 had postoperative radiotherapy. Although there is no statistical significance according to the Log-Rank test (p=0.7), the patients treated with radiation therapy seem to have a better chance of survival. Patients who had adjuvant chemotherapy (only 5) showed survival times similar to those patients who had none. Although clinical behaviour of central nervous system chondrosarcomas remains to be defined, data from our series as well as literature show that radical removal is the best therapeutic choice. In addition, patients treated with postoperative radiotherapy seem to show a trend toward increased survival

  12. Sustaining volcanism in Central Kamchatka

    Science.gov (United States)

    Nikulin, Alex

    Flux-induced melting in the mantle wedge acts as the driving mechanism of arc volcanism in subduction zone environments. The primary control on the geographical position of arc volcanic centers is the depth of the subducting plate beneath the overriding plate. Globally, the average depth to the subducting plate beneath volcanic arcs is estimated at ˜100km. Volcanoes of the Central Kamchatka Depression in Eastern Russia comprise the most active volcanic arc system in the world with the depth of the subducting Pacific plate beneath the arc estimated at 180-200km, greatly in excess of the global average. In my research I attempt to describe the special tectonic circumstances that explain the deviation of the subduction depth constraint on arc volcanism in Central Kamchatka. In my study I rely on geophysical and geochemical data and petrological modeling to propose a new geodynamic model to explain voluminous volcanic activity in Central Kamchatka. In the initial stage of the study I conducted a geophysical investigation using receiver function methodology to map and describe the contact of the subducting Juan de Fuca Plate in the well-instrumented Cascadia subduction zone. I calculated and compiled a database of receiver function profiles from stations along the extent of the Cascadia forearc and mapped a low velocity anisotropic zone proposed to be serpentinized material along the forearc axis. In the second stage of my study I applied a similar methodology to describe the sub-crustal structure of Central Kamchatka. Results of this effort suggested presence of a low-velocity zone in the upper mantle separate from the subducting Pacific plate. I proceeded to investigate the tectonic origin of this feature in the final stage of my dissertation work with the use of receiver function migration, geochemical analysis and petrological modeling. I was able to further constrain the position of the low velocity anomaly and derive geochemical and petrological evidence linking

  13. Central hypersensitivity in chronic musculoskeletal pain

    DEFF Research Database (Denmark)

    Curatolo, Michele; Arendt-Nielsen, Lars

    2015-01-01

    Clinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold...... standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central...... level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity....

  14. From Centrality to Temporary Fame: Dynamic Centrality in Complex Networks

    CERN Document Server

    Braha, D; Braha, Dan; Bar-Yam, Yaneer

    2006-01-01

    We develop a new approach to the study of the dynamics of link utilization in complex networks using records of communication in a large social network. Counter to the perspective that nodes have particular roles, we find roles change dramatically from day to day. "Local hubs" have a power law degree distribution over time, with no characteristic degree value. Our results imply a significant reinterpretation of the concept of node centrality in complex networks, and among other conclusions suggest that interventions targeting hubs will have significantly less effect than previously thought.

  15. Kalmanovitz y la Banca central / Kalmanovitz and central banking

    OpenAIRE

    Maya Muñoz, Guillermo

    2004-01-01

    Salomón Kalmanovitz, Codirector del Banco de la República (B de la R) hasta enero de 2005, uno de los economistas colombianos más brillantes, publicó un libro titulado Ensayos sobre Banca Central, Comportamiento, Independencia e Historia (Norma, 2003). Si los estudiantes de economía de los años 70 y 80 estudiaron a un Kalmanovitz marxista, los estudiantes de hoy estudian a un economista ortodoxo y liberal, igualmente brillante. Kalmanovitz es un partidario de la independencia de la BC para la...

  16. 羅振玉日本教育考察與晚清學制制定的關係 Chen-Yu Lo’ Educational Visit to Japan and the Drafting of School Systems in Late Ch’ing

    Directory of Open Access Journals (Sweden)

    周愚文 Yu-Wen Chou

    2015-03-01

    materials public, and published his account of the visit to Japan, he also presented his own version of educational plan in the Journal “Education World”. Unfortunately Lo was not engaged in the planning the Ren-yin and Kuei-mao school systems, and his publications were only used as one of reference sources, even though two of his proposals probably adapted by the officials in charge. The planner of Kuei-mao, I Chen, was a translator of several Japanese education acts and he took the educational visit to Japan with Lo; however, because the key policy-makers were inexperienced the school system borrowed from Japan could not completely meet the educational need of Ch’ing dynasty.

  17. Un episodio del pensamiento francés de la autonomía. Benjamin Constant y las idées très ingénieuses

    Directory of Open Access Journals (Sweden)

    Francisco Gelman Constantin

    2014-03-01

    Full Text Available UN EPISODIO DEL PENSAMIENTO FRANCÉS DE LA AUTONOMÍA Benjamin Constant y las idées très ingénieuses   Francisco Gelman Constantin Facultad de Filosofía y Letras, Universidad de Buenos Aires     Abstract – This paper attempts a consideration of the significance of Benjamin Constant’s aesthetic thoughts within the context of the history of the concept of “aesthetic autonomy”. With that in mind it reevaluates his transformation of the German tradition, by way of its binding to the social theory corresponding to the cultural and historical analysis of early French Romanticism. Taking the coinage of the expression “art for art’s sake” as a starting point, this paper reconstructs the whole of Constant’s thought-system, as well as its exchanges with some of his contemporaries –namely Mme. de Staël and Henry Crabb Robinson– in the means of understanding the proper reach of the conceptual novelties brought in by him, as can be seen from the standing point of Begriffsgeschichte. The paper deals not only with his postulates referring specifically to a negative relationship towards the mercantile society, but also with the analogies he establishes between art, love, religion and morality, while it furthermore examines his theory of social autonomy. The reflexive setting together of this different elements, assembled from his political essays, his journals, the novel Adolphe and other writings, brings to the light a general form of a thought of the autonomous, which explains the manner in which Constant understands aesthetic autonomy in particular, by way of his collaboration and dissent with his European colleagues.   Keywords: autonomy; Constant; art for art’s sake; Begriffsgeschichte; religion     Resumen – Este trabajo se propone reconsiderar la importancia de las reflexiones estéticas de Benjamin Constant en el contexto de la historia del concepto de autonomía estética. Para ello reevalúa las transformaciones

  18. Impacts des TIC sur l’enseignement et l’apprentissage des conceptions relatives au champ électrostatique en classes préparatoires aux grandes écoles d’ingénieurs (CPGE

    Directory of Open Access Journals (Sweden)

    Abdelaziz Bouchaib

    2011-01-01

    Full Text Available [Français] Cet article décrit une séquence d’enseignement au cours de laquelle nous avons expérimenté les ressources numériques du site Université en Ligne (UeL, relatives au module d’électrostatique, avec des étudiants de la première année des classes préparatoires aux grandes écoles d’ingénieurs. Nous rappelons brièvement les difficultés conceptuelles rencontrées chez les étudiants de premier cycle universitaire dans le domaine de l’électrostatique. La description de la séquence, expérimentée durant trois années consécutives en deux versions, est suivie d’une analyse des perceptions des étudiants à propos du site UeL. Cette analyse montre que les étudiants sont largement satisfaits du contenu, de la clarté et de la motivation que le site procure dans l’apprentissage. Nous étudions ensuite l’apport de l’UeL sur les conceptions des étudiants participant à l’expérimentation à propos du champ électrostatique créé par une charge ponctuelle et du principe de superposition des champs créés par deux charges ponctuelles. Les résultats montrent que, lorsque les ressources de l’UeL sont intégrées en situation d’auto-apprentissage accompagné par un enseignant tuteur, elles permettent une bonne appropriation de ces concepts et une meilleure interprétation des situations utilisées comme instrument d’évaluation. [English] This article describes a teaching sequence in which we have experimented digital resources of “online university (UeL” site related to Electrostatics module with students of the first year of preparatory classes for engineering schools. We briefly remind the conceptual difficulties faced by the first cycle university students in the domain of Electrostatics. The sequence description experienced during three consecutive years in two versions is followed by an analysis of students’ perception of UeL site. This analysis shows that students are widely satisfied of the

  19. CHINA AND ENERGY SECURITY IN CENTRAL ASIA

    OpenAIRE

    Guang, PAN

    2007-01-01

    This paper is divided into three parts: China’s energy policy and energy development strategy; Central Asia’s significance for China’s overseas energy development strategy; and Central Asia’s energy security and energy development.

  20. Biomass energy in Central America

    International Nuclear Information System (INIS)

    The objective of this paper is to introduce the concept of biomass to energy issues and opportunities in Central America. In this region, made up of seven countries (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua and Panama), the biomass sector has the potential to play a crucial role in alleviating the environmental and development predicaments faced by all economies of the region. This paper assesses the available biomass resources at the regional and country levels and gives an overview of the current utilization of biomass fuels. It also describes the overall context in which the biomass-to-energy initiatives are immersed. At the regional level, biomass energy consumption accounts for more than 50% of total energy consumption. In regard to the utilization of biomass for energy purposes, it is clear that Central America faces a critical juncture at two levels, both mainly in rural areas: in the productive sector and at the household level. The absence of sustainable development policies and practices has jeopardized the availability of biomass fuels, particularly wood. Firewood is an important source of energy for rural industries such as coffee processing, which is one of the largest productive activities in the region. This paper comments on some of the most successful technological innovations already in place in the region, for instance, the rapid development of co-generation projects by the sugar cane industry, especially in El Salvador and Guatemala, the substitution of coffee husks for firewood in coffee processing plants in Costa Rica and El Salvador and the sustainable use of pine forests for co-generation in Honduras. Only one out of every two inhabitants in Central America now has access to electricity from the public grid. Biomass fuels, mainly firewood but also, to a lesser extent, other crop residues such as corn stalks, are the main source of energy for cooking and heating by most of the population. (It is foreseen that by the end

  1. Neurocitoma no sistema nervoso central

    Directory of Open Access Journals (Sweden)

    José Torquato Severo

    1973-03-01

    Full Text Available É relatado o caso de uma paciente com 6 anos de idade, hospitalizada com síndrome de hipertensão intracraniana. Após o exame neuro-radiológico que evidenciou processo expansivo frontal direito, a paciente foi submetida à cirurgia, durante a qual ocorreu o óbito. O exame histo-patológico do material retirado durante o ato operatório, permitiu o diagnóstico de neurocitoma, tumor raro no sistema nervoso central.

  2. The ZEUS central tracking detector

    International Nuclear Information System (INIS)

    The Central Tracking Detector (CTD) of ZEUS covers a wide angular range, whilst the Forward Detector - comprising the Forward Tracking Detector (FTD) and electron identification by transition radiation - concentrates on the important forward cone. The RTD (Rear Tracking Detector) provides accurate angle measurement of the recoil electron and the vertex detector (VXD) aims to find particles from heavy flavour decay. To measure momentum accurately the CTD sits in a high magnetic field (B=1,8 T) within the ZEUS calorimeter. (orig./HSI)

  3. Central Clearing of OTC Derivatives

    DEFF Research Database (Denmark)

    Cont, Rama; Kokholm, Thomas

    2014-01-01

    netting agreements. When a CCP exists for interest rate derivatives, adding a CCP for credit derivatives is shown to decrease overall exposures. These findings are shown to be robust to the statistical assumptions of the model as well as the choice of risk measure used to quantify exposures....... classes are realistically taken into account. We argue that empirically plausible specifications of model parameters lead to the conclusion that central clearing does reduce interdealer exposures: the gain from multilateral netting in a CCP overweighs the loss of netting across asset classes in bilateral...

  4. Legal and actual central bank independence

    OpenAIRE

    Artha, I.K.D.S.; J. de Haan

    2010-01-01

    Indicators of central bank independence (CBI) based on the interpretation central bank laws in place may not capture the actual independence of the central bank. This paper develops an indicator of actual independence of the Bank Indonesia (BI), the central bank of Indonesia, for the period 1953-2008 and compares it with a new legal CBI indicator based on Cukierman (1992). The indicator of actual independence captures institutional and economic factors that affect CBI. We find that before 199...

  5. Distributed trace using central performance counter memory

    Science.gov (United States)

    Satterfield, David L.; Sexton, James C.

    2013-01-22

    A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.

  6. Evidence for Central Regulation of Glucose Metabolism*

    OpenAIRE

    Carey, Michelle; Kehlenbrink, Sylvia; Hawkins, Meredith

    2013-01-01

    Evidence for central regulation of glucose homeostasis is accumulating from both animal and human studies. Central nutrient and hormone sensing in the hypothalamus appears to coordinate regulation of whole body metabolism. Central signals activate ATP-sensitive potassium (KATP) channels, thereby down-regulating glucose production, likely through vagal efferent signals. Recent human studies are consistent with this hypothesis. The contributions of direct and central inputs to metabolic regulat...

  7. "Christofest" New Yorgi Central Parkis / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2004-01-01

    12. II 2005. a. avatakse Christo ja Jeanne-Claude'i keskkonnainstallatsioon "The Gates" New Yorgi Central Parkis. Paralleelselt toimub Metropolitan Muuseumis näitus "Christo and Jeanne-Claude : The Gates, Central Park, New York", kus eksponeeritakse Central Parki installatsiooni ettevalmistavaid materjale: joonistusi, diagramme, fotosid jne

  8. An Exploration on Unconscious Centralization and Leadership Decision-making%权力非意识集聚与领导决策探微

    Institute of Scientific and Technical Information of China (English)

    李世雄

    2013-01-01

      权力非意识集聚不仅是集权的一种形式,同时也是集权现象得以存在的核心支撑要素之一,它具有“非有意性”的本质特征,在上下级权力意识差异性、领导权威以及群体压力等因素作用下得以形成,它是集权现象持续存在并不断得到强化的根本原因,对领导决策产生重要影响。克服它对领导决策的负面影响必须从其本质特征入手,通过改善组织成员潜意识中对权力运作体系的相关认知来有效改善权力集聚的非意识形态。%The non-conscious centralization of power is not only a form of centralization but also one of key supporting elements of its existence.It has the essential characteristic of non-conscious, which is caused by the differences of superior-subordinate power consciousness, leading authority, the group pressure and so on.It is the fundamental reason for power centralization lasting and being continually strengthened.The non-conscious centralization of power has significant impact on the leadership decision -mak-ing.To overcome its negative effects , we should starting with its essential characteristic , and effectively improve the non-con-scious centralization of power through improving the related knowledge about the system of power operation in group members 'sub-conscious awareness.

  9. Hazardous pesticides in Central America.

    Science.gov (United States)

    Wesseling, C; Aragón, A; Castillo, L; Corriols, M; Chaverri, F; de la Cruz, E; Keifer, M; Monge, P; Partanen, T J; Ruepert, C; van Wendel de Joode, B

    2001-01-01

    Pesticides are an extensively documented occupational and environmental hazard in Central America. Yet, severe problems persist. Toxic pesticide use in the Region increased during 1985-1999. High exposure levels and ineffectiveness of personal protective equipment evidence the difficulties for risk reduction. Acute poisonings remain a severe problem. Delayed and/or long-lasting health effects include dermatoses, cancer, and genotoxic, neurotoxic, and respiratory effects. The use of hazardous pesticides persists through deficiencies in government-driven assessment and risk management; excessive focus on regional harmonization; short-term economic interests; strong links between industry and governments; aggressive marketing; weak trade unions; and failure of universities to reach decision makers. Regulation based on local data is lacking. An agreement of the Ministries of Health for restricting the most toxic pesticides in Central America has potential for progress. The most effective way to reduce risk is to greatly reduce pesticide use. Actions needed include development of multidisciplinary strategies for local studies on health and environmental impact of pesticides; development of sustainable nonchemical agricultural technologies; evaluation of interventions; extending and sharing of expertise within the Region; strengthening of unions and communities; and redefining the role of industry toward development of safer products, with responsible marketing and reliable information. PMID:11783858

  10. Central and forward tracking collaboration

    International Nuclear Information System (INIS)

    The goal of this subsystem R ampersand D project is to carry out a detailed study and design of a complete wire chamber tracking system covering pseudorapidity |η| ≤ 2.5 in a solenoidal detector for the SSC. Most of our group are now part of the Solenoidal Detector Collaboration (SDC), so the work has evolved into developing a tracking system conceptual design for the SDC detector. The design discussed in this report uses straw tube drift chambers for the central tracking region. Because of the high rates in the SSC environment, a small cell design is needed for wire chambers in the central region. Straw tubes as small cells offer many advantages because the sense wire is enclosed in a continuous cathode, and the wire tension due to the sense wire only can be supported without a massive structure. The straw tubes are grouped together to form superlayers in order to provide local track segments. The superlayers are composed of modules consisting of about two hundred straw tubes enclosed in a carbon fiber composite shell. Straw tubes have been used in previous experiments for small vertex drift chambers. However, they have never before been used for a large tracking system

  11. 集中供热管网工程井室逆作法施工方案设计%The construction scheme design of well chamber reverse construction method of central heating pipe network engineering

    Institute of Scientific and Technical Information of China (English)

    周彬

    2014-01-01

    Combining with the construction scheme design of well chamber reverse construction method of central heating pipe network engineer-ing,this paper elaborated in detail the main contents of soil excavation,crown beam construction,concrete pouring and each construction process in well chamber reverse construction method,summarized the matters needing attention in construction process,accumulated experience for heat supply engineering construction.%结合集中供热管网工程井室逆作法施工设计方案,详细阐述了井室逆作法施工过程中土方开挖、冠梁施工、混凝土浇筑等各个施工工序的主要内容,总结了施工过程中需注意的事项,为供热工程施工积累了经验。

  12. 中枢性嗜眠症%Hypersomnia of central origin

    Institute of Scientific and Technical Information of China (English)

    陈静; 陈贵海

    2014-01-01

    中枢性嗜眠症是在排除呼吸相关的睡眠障碍、生理节律紊乱及夜间睡眠干扰等因素后,以日间睡眠增多为首要主诉的睡眠异常。它包括发作性睡病、特发性嗜眠症、复发性嗜眠症、行为诱发的睡眠不足综合征、疾病状态相关性嗜眠症、药物相关性嗜眠症等多个睡眠障碍类型,不同程度地影响人们的生活质量乃至生命安全。其中绝大多数的发病机制均未明确。药物治疗上多侧重于促醒、兴奋等对症处理,行为治疗尤其对发作性睡病和特发性嗜眠症患者不可或缺。未来对于中枢性嗜眠症的研究需要更加致力于其发病机制以及治疗方法的探索,期待有更大样本的临床研究。%Hypersomnia of central origin,in which the primary complaint is excessive daytime sleep,is a group of sleep disorders including narcolepsy,idiopathic hypersomnia,recurrent hypersomnia,behaviorally induced insuffient sleep syndrome,hy-persomnia due to medical conditions and hypersomnia due to drug or substance intake.It is not caused by sleep-disordered breath-ing,misaligned circadian rhythms or disturbed nocturnal sleep,and can influence the quality and safety of life in certain degrees. The treatment for hypersomnia of central origin focus on stimulants and waking-promoting agents targeting at symptom improve-ment simply,for its pathogenesis is still unclear.Moreover,behavioral management can also make a significant impact,espacially for narcolepsy and idiopathic hypersomnia.In the futrue,the research of hypersomnia of central origin needs to struggle for the ex-ploration of the pathogenesis and therapy,expecting more large sample clinical researchs.

  13. Central Solenoid Insert Technical Specification

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, Nicolai N [ORNL; Smirnov, Alexandre [ORNL

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  14. 76 FR 22746 - Wiregrass Central Railway, LLC-Acquisition and Operation Exemption-Wiregrass Central Railroad...

    Science.gov (United States)

    2011-04-22

    ... Surface Transportation Board Wiregrass Central Railway, LLC--Acquisition and Operation Exemption--Wiregrass Central Railroad Company, Inc. Wiregrass Central Railway, LLC (WCR), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to acquire from Wiregrass Central Railroad Company,...

  15. Central Exclusive Production at LHCb

    CERN Document Server

    McNulty, Ronan

    2016-01-01

    Central Exclusive Production (CEP) is a unique process at hadron machines in which particles are produced via colourless propagators. LHCb have measured the cross-sections for the CEP of vector mesons, $J/\\psi,\\psi(2S),\\Upsilon(1S),\\Upsilon(2S)$ and $\\Upsilon(3S)$, which are photo-produced. In the double pomeron exchange process, preliminary measurements have been made of $\\chi_{c0},\\chi_{c1}, \\chi_{c2}$ meson production while the first observations of the CEP of pairs of charmonia, $J/\\psi J/\\psi$ and $J/\\psi \\psi(2S)$, have been made and limits obtained on the pair production of other charmonia.

  16. WINE MARKETS IN CENTRAL EUROPE

    Directory of Open Access Journals (Sweden)

    Š BOJNEC

    2007-04-01

    Full Text Available This paper analyses the tendencies of grapes growing, wine trading and wine price competitiveness in Central European region. Croatia is net exporter of wines, Hungary is net exporter of grapes and wines, and Austria, Slovakia, and Slovenia are net importers of grapes and wines. Reductions in vineyards and increase in yields are found for Austria, Hungary, and Slovakia. More stable developments in vineyards, but decline in yields, are found for Croatia and Slovenia. Grape production increases in Austria, remains stable in Croatia, explores annual oscillations in Hungary, and declines in Slovakia and Slovenia. Export-to-import wine prices deteriorate for Austria and Hungary with most recent stabilization and price similarity, which hold also for Slovakia. Slovenian export-to-import wine prices are unstable, while Croatia experiences a bit higher export than import wine prices. Wine marketing, wine brand image of quality, and wine tourism are seen as tools to improve competitiveness in the wine sector.

  17. Fermilab central helium liquefier operations

    International Nuclear Information System (INIS)

    This chapter discusses the use of liquid helium to cool the Fermilab superconducting accelerator. Liquid from the Central Helium Liquefier (CHL) is transported in a six kilometer circular transfer line and each satellite withdraws the amount required to boost its refrigeration capacity to the necessary level. Topics considered include the compressor, the heater, the control system, gas storage, liquid storage, the nitrogen reliquefier, gas purification, initial and early operation, and recent operation. The liquid helium is warmed to near ambient temperature in the satellite heat exchangers. The satellite compressors return the excess inventory to the CHL via a 20 bar gas header. This gas is injected into the high pressure supply to the cold box. Some turbine instabilities have been experienced, including the destruction of a turbine during the initial start-up

  18. Elements of Poro-Elasticity for Reservoir Engineering Éléments de poro-élasticité pour l'ingénierie de réservoirs

    Directory of Open Access Journals (Sweden)

    Bouteca M.

    2006-11-01

    -élasticité utiles à l'ingénieur de réservoir. La poro-élasticité permet de calculer les déformations du solide liées au mouvement du fluide. C'est donc le cadre théorique qui permet de définir la compressibilité de la roche. Nous montrons ainsi, dans un premier temps, comment les variables mécaniques précédemment introduites sont reliées à la compressibilité de la roche mesurée expérimentalement. Deux hypothèses sont retenues : a mesure en condition isotrope (définie par une pression de confinement et une pression de pore, b mesure en condition oedométrique (définie par un chargement vertical, un déplacement radial nul et une pression de pore. Les principaux résultats sont illustrés dans le tableau 6. On montre en outre qu'en condition isotrope, la compressibilité du volume poreux peut être mesurée indifféremment à pression de pore variable et pression de confinement constante ou à pression de pore constante et pression de confinement variable (tableau 5. Dans un deuxième temps nous examinons sous quelles conditions l'équation de diffusivité définie dans la première partie peut être découplée de l'équation d'équilibre du solide. On montre que la contribution de la déformation de la roche à l'écoulement peut être exprimée à l'aide d'un coefficient de compressibilité à condition que l'on fasse des hypothèses sur le mode de déformation local de la roche. Rappelons que, par opposition à des conditions aux limites qui sont vraies sur le contour du domaine, les conditions locales sont vraies en tout point et constituent une simplification du problème réel. En conclusion, on souligne l'importance du choix des conditions locales retenues pour la mesure de la compressibilité de la roche. La compressibilité de la roche étant définie, l'équation de diffusivité prend sa forme classique : la contribution de la roche est introduite en définissant une compressibilité totale somme de la compressibilité du fluide et de celle de la roche.

  19. Projet pédagogique et ingénierie de l’unité didactique Proyecto pedagógico e ingeniería de la unidad didáctica

    Directory of Open Access Journals (Sweden)

    Christian Puren

    2012-02-01

    Full Text Available La nouvelle « perspective actionnelle » ébauchée dans le Cadre Européen Commun de Référence pour les Langues (CECRL, Didier 2001 se donne comme finalité la formation d’un « acteur social ». Cette finalité amène tout naturellement à considérer le « projet pédagogique » comme activité de référence parce qu’il engage par définition les apprenants comme des acteurs sociaux à part entière de leur propre projet d’apprentissage dans l’espace de la classe et pendant le temps de leur apprentissage. C’est (ou ce devrait être particulièrement le cas dans des environnements d’enseignement-apprentissage tels que les IUT, où les projets pédagogiques proposés par les enseignants peuvent soit simuler de futures activités professionnelles, soit correspondre à des projets réels tels que ceux impliquant la conception, la préparation, la réalisation et l’exploitation de stages de terrain à l’étranger. On se propose d’examiner ici la nouvelle question d’ingénierie didactique qui se pose du coup aux enseignants et concepteurs de matériels didactiques : comment concilier la logique (d’autonomie maximale et le temps (long des projets pédagogiques avec un dispositif ‒ ladite « unité didactique » ‒ qui reste malgré tout nécessaire, mais qui obéit à une logique contraire (celle de la pré-programmation des contenus et des activités et à un temps plus court.El nuevo “enfoque orientado a la acción” esbozado en el Marco Común Europeo de Referencia para las Lenguas (edición francesa Didier 2001 se fija como finalidad la formación de un “actor social”. Si se aplica la ley de homología fin-medio ‒ según la cual el actuar de aprendizaje siempre debe ser el más parecido posible al actuar social ‒, tal finalidad supone natu-ralmente considerar el “proyecto pedagógico” como actividad de referencia, ya que en el proyecto los alumnos por definición se implican como unos

  20. GLOBAL FINANCIAL CRISIS AND UNIT-LINKED INSURANCE MARKETS EFFICIENCY: EMPIRICAL EVIDENCE FROM CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Botoş Horia Mircea

    2012-12-01

    Full Text Available This paper empirically investigates the impact of the Global financial crisis on the efficiency of four Central and Eastern European emerging unit-linked insurance markets, applying the automatic variance ratio (AVR test of Kim (2009 and variance ratio tests using ranks and signs by Wright (2000 for entire, pre-crisis and crisis periods. This study contributes to the existing literature on efficient market hypothesis with several distinct features: it provides a systematic review of the weak-form market efficiency literature that examines return predictability of the daily ING unit-linked funds prices; also the article aims at monitoring any improvement in the degree of efficiency in time and also examines the relative efficiency of unit-linked insurance markets in pre-crisis and crisis periods. Unit linked insurance are life insurance policies with investment component. In the literature there are few studies investigating the effects of a financial crisis on the potential of predictability and implicitly on the degree of efficiency of financial markets. The occurrence of a market crash or financial crisis is a possible contributing factor of market inefficiency. Most of the studies are focused on the Asian crisis in 1997: Holden et al. (2005 examined the weak-form efficiency of eight emerging Asian stock markets using VR tests before, during and after the Asian crisis; Kim and Shamsuddin (2008 used three different types of multiple VR tests for nine Asian stock markets; the findings reported by Lim et al. (2008 are consistent with those reported by Cheong et al. (2007, in which the highest inefficiency occurs during the crisis period. Todea and Lazar (2010 investigated the effects of the Global crisis on the relative efficiency of ten CEE stock markets, using Generalized Spectral test of Escanciano and Velasco (2006. Wright (2000 proposes the alternative non-parametric variance ratio tests using ranks and signs of return and demonstrates that

  1. A tectonomagnetic effect detected in Central Italy

    Directory of Open Access Journals (Sweden)

    P. Palangio

    1994-06-01

    Full Text Available Significant variations in the absolute value of the geomagnetic field intensity related to tectonic events, as earthquakes and volcanic eruptions, have been observed in several cases. To detect such a tectonomagnetic effect related to seismic activity, a seismomagnetic network was installed by the Istituto Nazionale di Geofisica (ING in the Abruzzi region (CentraI Italy, in July 1989. This area is being uplifting since the Pliocene. A logistic compromise between geophysical requirements and the electrified railway system tracks distribution led to the installation of five total magnetic field intensity data acquisition sites. From July 1989 to September 1992 geomagnetic intensity data were simultaneously recorded at all stations and compared to that recorded at the L'Aquila Observatory, located in the same area. A variation of about 10 nT in the absolute level of the geomagnetic field was measured at two stations located on the eastern side of the network. We suggest that the detected magnetic anomaly could resuIt from aseismic-changes in crustal stress during this time.

  2. Hirsch index as a network centrality measure

    CERN Document Server

    Campiteli, Monica G; Soles, Paulo R C; Soares, Leonardo H D; Kinouchi, Osame

    2010-01-01

    We study the h Hirsch index as a local node centrality measure for complex networks in general. The h index is compared with the Degree centrality (a local measure), the Betweenness and Eigenvector centralities (two non-local measures) in the case of a biological network (Yeast interaction protein-protein network) and a linguistic network (Moby Thesaurus II) as test environments. In both networks, the Hirsch index has poor correlation with Betweenness centrality but correlates well with Eigenvector centrality, specially for the more important nodes that are relevant for ranking purposes, say in Search Machine Optimization. In the thesaurus network, the h index seems even to outperform the Eigenvector centrality measure as evaluated by simple linguistic criteria.

  3. Reduced central blood volume in cirrhosis

    DEFF Research Database (Denmark)

    Bendtsen, F; Henriksen, Jens Henrik Sahl; Sørensen, T I; Stadeager, C; Ring-Larsen, H

    1989-01-01

    The pathogenesis of ascites formation in cirrhosis is uncertain. It is still under debate whether the effective blood volume is reduced (underfilling theory) or whether the intravascular compartment is expanded (overflow theory). This problem has not yet been solved because of insufficient tools...... for measuring the central blood volume. We have developed a method that enables us to determine directly the central blood volume, i.e., the blood volume in the heart cavities, lungs, and central arterial tree. In 60 patients with cirrhosis and 16 control subjects the central blood volume was assessed...... according to the kinetic theory as the product of cardiac output and mean transit time of the central vascular bed. Central blood volume was significantly smaller in patients with cirrhosis than in controls (mean 21 vs. 27 ml/kg estimated ideal body weight, p less than 0.001; 25% vs. 33% of the total blood...

  4. Central sleep apnea – a case report

    OpenAIRE

    Dybala Andrzej; Dyczko Monika; Makaruk Boguslaw; Kicinski Pawel; Bartoszek Elzbieta; Myslinski Wojciech; Rahnama Mansur; Mosiewicz Jerzy

    2014-01-01

    Central sleep apnea (CSA) is a disease characterized by repetitive episodes of the socalled central apneas during sleep. The disease has a very complex etiology. In clinical practice, the most important causes of CSA are disorders of the central nervous system, congestive heart failure or certain pathological changes of the respiratory muscles. We present a case of a 43-year-old male with severe CSA, who was successfully treated with BiPAP ST equipment.

  5. Central sleep apnea – a case report

    Directory of Open Access Journals (Sweden)

    Dybala Andrzej

    2014-06-01

    Full Text Available Central sleep apnea (CSA is a disease characterized by repetitive episodes of the socalled central apneas during sleep. The disease has a very complex etiology. In clinical practice, the most important causes of CSA are disorders of the central nervous system, congestive heart failure or certain pathological changes of the respiratory muscles. We present a case of a 43-year-old male with severe CSA, who was successfully treated with BiPAP ST equipment.

  6. Clarity of Central Bank Communication About Inflation

    OpenAIRE

    Ales Bulir; David-Jan Jansen; Martin Cihak

    2011-01-01

    This paper examines whether the clarity of central bank communication about inflation has changed with the economic environment. We use readability statistics and content analysis to study the clarity of communication on the inflation outlook by seven central banks between 1997 and 2010. Overall, we find no strong indications that central banks were less clear in explaining their policies when faced with higher uncertainty or a less favorable inflation outlook. The global financial crisis, ho...

  7. 2. The Central American gang phenomenon

    OpenAIRE

    Does, Antonia

    2013-01-01

    2.1. Differentiating between pandillas and maras Youth gangs have existed since the 1960s and 1970s in Central America. However, there are different types of Central American gangs and thus one has to distinguish between pandillas and maras. The former are localized, homegrown gangs, which are “direct inheritors” (Jütersonke, Rodgers & Muggah 2009: 379) of the gangs that have historically characterized Central American societies, while the latter are a more recent phenomenon with transnationa...

  8. Central Neurogenic Respiratory Failure: A Challenging Diagnosis

    OpenAIRE

    Carvalho, Flávio A.; Bernardino, Tenille; Maciel, Ricardo O.H.; Felizola, Sérgio F.A.; Costa, Eduardo L.V.; Silva, Gisele S

    2011-01-01

    Background Central nervous system lesions are rare causes of respiratory failure. Simple observation of the breathing pattern can help localize the lesion, but the examiner needs to be aware of potential pitfalls such as metabolic or pulmonary alterations. Methods We describe 3 cases in which central neurogenic respiratory failure occurred simultaneously with other alterations or in an unusual presentation. Results All patients were diagnosed with central neurogenic respiratory failure and tr...

  9. Managing human resources - a central bank perspective

    OpenAIRE

    Donna Hickey; Geof Mortlock

    2002-01-01

    The adage that "people are our greatest asset" has been a recurrent theme in many businesses and organisations through history. This is no less true for a central bank. Indeed, people are, without doubt, a central bank's most important resource. Our business relies heavily on the expertise, experience and sound judgement of our staff. A central bank's effectiveness crucially depends on its credibility, and this in turn largely comes down to the quality of its staff. Therefore, managing human ...

  10. Transparency in Central Bank Financial Statement Disclosures

    OpenAIRE

    Kenneth Sullivan

    2000-01-01

    The IMF's development of the Code of Good Practices on Transparency in Monetary and Financial Policies and the introduction of safeguards assessments have increased emphasis on transparency of the disclosures made in central bank financial statements. This paper, which updates WP/00/186, looks at the disclosure requirements for central banks under International Financial Reporting Standards and provides practical guidance for those responsible for preparing central bank financial statements.

  11. On the Central Coefficients of Riordan Matrices

    OpenAIRE

    Barry, Paul

    2013-01-01

    We use the Lagrange-Bürmann inversion theorem to characterize the generating function of the central coefficients of the elements of the Riordan group of matrices. We apply this result to calculate the generating function of the central elements of a number of explicit Riordan arrays, defined by rational expressions, and in two cases we use the generating functions thus found to calculate the Hankel transforms of the central elements, which are themselves expressible as combinatorial polynomi...

  12. Urban history and modernity in Central Europe

    OpenAIRE

    Klautke, E. F.

    2010-01-01

    This historiographical review discusses recent literature on cities in modern Central Europe – mainly on Berlin and Vienna – which reflects the great variety of approaches to urban history and underlines the importance of urban history for the study of modernity. The history of urbanisation was a central event in the history of modernity. Especially in the Central European capitals of Berlin and Vienna, where modernisation and urban growth started later and then advanced quicker than in West ...

  13. Central banking and the economics of information

    OpenAIRE

    Green, Edward J.

    2001-01-01

    This article concerns the potential relevance of information technology to three aspects of central banking: setting the objectives of monetary policy, ensuring the integrity and security of financial system infrastructure, and maintaining the transparency of decision-making. Regarding integrity and security of infrastructure, a revised role for central banks may be appropriate. However, recent innovations in technology and advances in learning confirm the wisdom of central banks' efforts to ...

  14. The Information Value of Central School Exams

    OpenAIRE

    Schwerdt, Guido; Woessmann, Ludger

    2015-01-01

    The central vs. local nature of high-school exit exam systems can have important repercussions on the labor market. By increasing the informational content of grades, central exams may improve the sorting of students by productivity. To test this, we exploit the unique German setting where students from states with and without central exams work on the same labor market. Our difference-in-difference model estimates whether the earnings difference between individuals with high and low grades d...

  15. Transpleural central venous catheter discovered during thoracotomy

    OpenAIRE

    Ashima Malhotra; Prakash Sharma; Ashvini Kumar; Nikhil Malhotra

    2014-01-01

    We report an uncommon complication of subclavian central venous catheterization, discovered at thoracotomy. The central venous catheter (CVC) was placed by left infraclavicular route after induction of general anesthesia. CVC was secured after aspiration of blood and satisfactory central venous tracing. On thoracotomy, CVC was noticed to traverse the pleural cavity while the tracing was normal. CVC was thus removed consequent to which bleeding from each puncture site was noticed, that were se...

  16. The Centrality of Organization Design

    Directory of Open Access Journals (Sweden)

    Raymond E. Miles

    2012-05-01

    Full Text Available I am excited about this new journal focused on the subject of organization design. In my view, organization design is a central issue in the field of management. Designing an organization requires an understanding of strategy, as we pointed out some time ago (Miles & Snow, 1978. For example, if you want to be a prospector (a first-mover strategy, you have to design your firm to move quickly in new directions, which is likely to require that it be arranged so that various kinds of teams can interact across organizational units and levels. Designing an organization to follow a first-mover strategy also requires both an understanding of leadership and a commitment to the free flow of information throughout the organization. Leaders must understand how cross-functional teams pursue ideas and opportunities, and they must facilitate collaborative knowledge sharing to drive innovations that help the firm operate entrepreneurially. Because an organization is a complex, dynamic system, perhaps no other single topic is so deeply implanted at the core of management, organization theory, and organizational behavior as organization design. Moreover, organization design once was, and could be again, the topic of an ongoing dialogue between managers and academics focused on business organizations.

  17. Central nervous system tuberculosis: MRI

    International Nuclear Information System (INIS)

    The MRI findings of 18 proven cases of central nervous system (CNS) tuberculosis were reviewed; 10 patients were seropositive for HIV. All had medical, laboratory, or surgical proof of CNS tuberculosis. Eleven patients had meningitis, of whom two also had arachnoiditis. Five patients had focal intra-axial tuberculomas: four brain masses and one an intramedullary spinal lesion. Two patients had focal extra-axial tuberculomas: one in the pontine cistern, and one in the spine. In all 11 patients with meningitis MRI showed diffuse, thick, meningeal enhancement. All intraparenchymal tuberculomas showed low signal intensity on T2-weighted images and ring or nodular enhancement. The extra-axial tuberculomas had areas isointense or hypointense relative to normal brain and spinal cord on T2-weighted images. Although tuberculous meningitis cannot be differentiated from other meningitides on the basis of MR findings, intraparenchymal tuberculomas show characteristic T2 shortening, not found in most other space-occupying lesions. In the appropriate clinical setting, tuberculoma should be considered. (orig.)

  18. A Central Theory of Biology

    Science.gov (United States)

    Torday, John S.

    2015-01-01

    The history of physiologic cellular–molecular interrelationships can be traced all the way back to the unicellular state by following the pathway formed by lipids ubiquitously accommodating calcium homeostasis, and its consequent adaptive effects on oxygen uptake by cells, tissues and organs. As a result, a cohesive, mechanistically integrated view of physiology can be formulated by recognizing the continuum comprising conception, development, physiologic homeostasis and death mediated by soluble growth factor signaling. Seeing such seemingly disparate processes as embryogenesis, chronic disease and dying as the gain and subsequent loss of cell–cell signaling provides a novel perspective for physiology and medicine. It is emblematic of the self-organizing, self-referential nature of life, starting from its origins. Such organizing principles obviate the pitfalls of teleologic evolution, conversely providing a way of resolving such seeming dichotomies as holism and reductionism, genotype and phenotype, emergence and contingence, proximate and ultimate causation in evolution, cells and organisms. The proposed approach is scale-free and predictive, offering a Central Theory of Biology. PMID:25911556

  19. Towards a centralized Grid Speedometer

    International Nuclear Information System (INIS)

    Given the distributed nature of the Worldwide LHC Computing Grid and the way CPU resources are pledged and shared around the globe, Virtual Organizations (VOs) face the challenge of monitoring the use of these resources. For CMS and the operation of centralized workflows, the monitoring of how many production jobs are running and pending in the Glidein WMS production pools is very important. The Dashboard Site Status Board (SSB) provides a very flexible framework to collect, aggregate and visualize data. The CMS production monitoring team uses the SSB to define the metrics that have to be monitored and the alarms that have to be raised. During the integration of CMS production monitoring into the SSB, several enhancements to the core functionality of the SSB were required; They were implemented in a generic way, so that other VOs using the SSB can exploit them. Alongside these enhancements, there were a number of changes to the core of the SSB framework. This paper presents the details of the implementation and the advantages for current and future usage of the new features in SSB.

  20. A partitioned central solar receiver

    International Nuclear Information System (INIS)

    Else of solar energy as substitute for conventional fuels at a competitive cost requires efficient conversion from solar radiation to usable forms of energy. In solar thermal or thermochemical applications, high efficiency usually re- quires high temperature and high concentration of incoming radiation. The main form of energy loss from high temperature solar central receivers is thermal emission ('re radiation'), at an effective temperature close to the maximum receiver temperature. This loss is reduced if the aperture is divided into segments, most of which are maintained at lower temperatures. A two-stage partitioned receiver demonstrating this concept is under construction at the Weizman Solar Tower. The high-temperature stage is the DIAPR (Directly Irradiated Annular Pressurized Receiver). The low-temperature stage is made of tubular cavity receivers of simpler design. Preliminary optical and thermal design of the partitioned receiver is presented. For the design exit temperature of 1500 K, the aperture size of the partitioned receiver is about 60% of the equivalent single-stage receiver, indicating a significant increase of conversion efficiency. The exit temperature of the low-temperature stage is around 1100 K, allowing simpler design and inexpensive construction. (authors)

  1. Conductivity Anomalies in Central Europe

    Science.gov (United States)

    Neska, Anne

    2016-01-01

    This paper is a review of studies which, by applying the magnetotelluric, geomagnetic deep sounding, and magnetovariational sounding methods (the latter refers to usage of the horizontal magnetic tensor), investigate Central Europe for zones of enhanced electrical conductivity. The study areas comprise the region of the Trans-European Suture Zone (i.e. the south Baltic region and Poland), the North German Basin, the German and Czech Variscides, the Pannonian Basin (Hungary), and the Polish, Slovakian, Ukrainian, and Romanian Carpathians. This part of the world is well investigated in terms of data coverage and of the density of published studies, whereas the certainty that the results lead to comprehensive interpretations varies within the reviewed literature. A comparison of spatially coincident or adjacent studies reveals the important role that the data coverage of a distinct conductivity anomaly plays for the consistency of results. The encountered conductivity anomalies are understood as linked to basin sediments, asthenospheric upwelling, large differences in lithospheric age, and—this concerns most of them, which all concentrate in the middle crust—tectonic boundaries that developed during all mountain building phases that have taken place on the continent.

  2. Pyramidal central configurations and perverse solutions

    OpenAIRE

    Zhifu Xie; Shiqing Zhang

    2004-01-01

    For $n$-body problems, a central configuration (CC) plays an important role. In this paper, we establish the relation between the spatial pyramidal central configuration (PCC) and the planar central configuration. We prove that the base of PCC is also a CC and we also prove that for some given conditions a planar CC can be extended to a PCC. In particular, if the pyramidal central configuration has a regular polygon base, then the masses of base are equal and the distance between the top vert...

  3. The primary Maxillary Central Incisor in the Solitary Median Maxillary Central Incisor syndrome

    DEFF Research Database (Denmark)

    Kjaer, I; Balslev-Olesen, M

    2012-01-01

    Solitary Median Maxillary Central Incisor (SMMCI) is a developmental anomaly in the permanent dentition with one single central incisor in the maxilla, positioned exactly in the midline. This condition has been associated with extra- and intraoral malformations in the frontonasal segment of the...... cranium and face. It is not known whether the centrally located permanent incisor is always preceded by a centrally located primary incisor. The aim was to analyse whether a permanent single central incisor in SMMCI is always preceded by a primary single central incisor and to study extra- and intraoral...

  4. Vers les démarches en ingénierie écologique pour la santé des plantes : gestion des couvre-sols des vergers pour lutter contre les bactérioses des arbres fruitiers provoquées par Pseudomonas syringae

    OpenAIRE

    Buisson, Elise; Parisi, Luciana; Morris, Cindy E.

    2013-01-01

    Ce poster présentera une thèse entamée à l’automne 2013 visant à contribuer au développement des pratiques de l’ingénierie écologique, et en particulier la gestion des couvre-sols afin de réduire leur impact en tant que source d’inoculum pour les bactérioses d’arbres fruitiers provoquées par Pseudomonas syringae et d’augmenter leur rôle en tant que réserve d’antagonistes aux micro-organismes générant les bactérioses des arbres fruitiers. La recherche a pour objectif global de contribuer à l’é...

  5. L'épistémologie et l'histoire des sciences et des techniques peuvent elles aider les futurs enseignants de sciences physiques dans l'exercice de leur métier ? Regards portés pour une ingénierie de formation

    Directory of Open Access Journals (Sweden)

    Guedj Muriel

    2014-01-01

    Full Text Available Cette étude interroge la place de l'Epistémologie, l'Histoire des Sciences et des Techniques comme élément pertinent pour améliorer la professionnalité des enseignants de sciences physiques. La réflexion se nourrit des nouvelles orientations prises au sein d'écoles d'ingénieurs et de facultés de médecine qui ont fait le choix d'introduire des unités d'enseignement dédiées aux Sciences Humaines et Sociales afin de perfectionner la qualité professionnelle de leurs formations. Une étude de cas dédiée à l'enseignement de l'énergie illustre le propos.

  6. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of a constant recharge value for the Central Oklahoma aquifer in central Oklahoma. This area encompasses all or part of...

  7. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of a constant hydraulic conductivity value for the Central Oklahoma aquifer in central Oklahoma. This area encompasses...

  8. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized water-level elevation contours for the Central Oklahoma aquifer in central Oklahoma. This area encompasses all or part of...

  9. Nuclear Energy in Central Europe 98, Proceedings

    International Nuclear Information System (INIS)

    Regional Meeting for Nuclear Energy in Central Europe is an annual meeting of the Nuclear Society of Slovenia. The proceedings contain 63 articles from Slovenia, sorounding countries and countries of the Central and Eastern European Region. Topics are: Research Reactors, Nuclear Methods, Reactor Physics, Thermal Hydraulics, Structural Analysis, Probabilistic Safety Assessment, Severe Accidents, NPP Operation and Nuclear Waste disposal

  10. The Cartan Matrix of a Centralizer Algebra

    Indian Academy of Sciences (India)

    Umesh V Dubey; Amritanshu Prasad; Pooja Singla

    2012-02-01

    The centralizer algebra of a matrix consists of those matrices that commute with it. We investigate the basic representation-theoretic invariants of centralizer algebras, namely their radicals, projective indecomposable modules, injective indecomposable modules, simple modules and Cartan matrices. With the help of our Cartan matrix calculations we determine their global dimensions. Many of these algebras are of infinite global dimension.

  11. A SCALED CENTRAL PATH FOR LINEAR PROGRAMMING

    Institute of Scientific and Technical Information of China (English)

    Ya-xiang Yuan

    2001-01-01

    Interior point methods are very efficient methods for solving large scale linear programming problems. The central path plays a very important role in interior point methods. In this paper we propose a new central path, which scales the variables. Thus it has the advantage of forcing the path to have roughly the same distance from each active constraint boundary near the solution.

  12. Improved closeness centrality using arithmetic mean approach

    Science.gov (United States)

    Ruslan, Nuraimi; Sharif, Shamshuritawati

    2015-12-01

    In this paper, we improved the mathematical formulation of closeness centrality measure for weighted network. The proposed measure is used arithmetic mean approach and the performance is successfully better than the existing closeness centrality. This measure can be used as a measure of influential nodes.

  13. CENTRAL PONTINE MYELINOLYSIS: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Chethan Belgur

    2014-04-01

    Full Text Available Central Pontine Myelinolysis is a clinically heterogeneous condition with difficult clinical and radiological diagnosis. When the condition is found outside pons it is called extrapontine myelinolysis which is together termed as osmotic demyelination syndrome. We present a case of central pontine myelinolysis with characteristic MR imaging features

  14. Visualizing the Central Limit Theorem through Simulation

    Science.gov (United States)

    Ruggieri, Eric

    2016-01-01

    The Central Limit Theorem is one of the most important concepts taught in an introductory statistics course, however, it may be the least understood by students. Sure, students can plug numbers into a formula and solve problems, but conceptually, do they really understand what the Central Limit Theorem is saying? This paper describes a simulation…

  15. Guidance and Orientation Manual : Internal Diseases Ward 11 - Central Finland Central Hospital

    OpenAIRE

    Hirjaba, Marina

    2009-01-01

    The purpose of this Bachelor’s Thesis is to create an initiation manual for the foreign students, foreign visitors or anyone else interested about Internal Diseases ward 11, Central Finland Central Hospital. The aim of the guidance material is to help the foreign students, who are practicing on ward 11, to become acquainted with the Finnish Healthcare System, Central Finland Central Hospital and to offer orientation upon the nursing and organisation of Internal Diseases ward 11. It is taken i...

  16. Central station market development strategies for photovoltaics

    Science.gov (United States)

    1980-01-01

    Federal market development strategies designed to accelerate the market penetration of central station applications of photovoltaic energy system are analyzed. Since no specific goals were set for the commercialization of central station applications, strategic principles are explored which, when coupled with specific objectives for central stations, can produce a market development implementation plan. The study includes (1) background information on the National Photovoltaic Program, photovoltaic technology, and central stations; (2) a brief market assessment; (3) a discussion of the viewpoints of the electric utility industry with respect to solar energy; (4) a discussion of commercialization issues; and (5) strategy principles. It is recommended that a set of specific goals and objectives be defined for the photovoltaic central station program, and that these goals and objectives evolve into an implementation plan that identifies the appropriate federal role.

  17. Central station market development strategies for photovoltaics

    Science.gov (United States)

    1980-11-01

    Federal market development strategies designed to accelerate the market penetration of central station applications of photovoltaic energy system are analyzed. Since no specific goals were set for the commercialization of central station applications, strategic principles are explored which, when coupled with specific objectives for central stations, can produce a market development implementation plan. The study includes (1) background information on the National Photovoltaic Program, photovoltaic technology, and central stations; (2) a brief market assessment; (3) a discussion of the viewpoints of the electric utility industry with respect to solar energy; (4) a discussion of commercialization issues; and (5) strategy principles. It is recommended that a set of specific goals and objectives be defined for the photovoltaic central station program, and that these goals and objectives evolve into an implementation plan that identifies the appropriate federal role.

  18. Reduced central blood volume in cirrhosis

    DEFF Research Database (Denmark)

    Henriksen, Jens Henrik; Bendtsen, Flemming; Sørensen, T I;

    1989-01-01

    was inversely correlated to the systemic vascular resistance (r = -0.49, p less than 0.001), the latter being significantly reduced in the patient group. Patients with cirrhosis apparently are unable to maintain a normal central blood volume. This may be due to arteriolar vasodilation, portosystemic collateral......The pathogenesis of ascites formation in cirrhosis is uncertain. It is still under debate whether the effective blood volume is reduced (underfilling theory) or whether the intravascular compartment is expanded (overflow theory). This problem has not yet been solved because of insufficient tools...... for measuring the central blood volume. We have developed a method that enables us to determine directly the central blood volume, i.e., the blood volume in the heart cavities, lungs, and central arterial tree. In 60 patients with cirrhosis and 16 control subjects the central blood volume was assessed according...

  19. The central curve in linear programming

    CERN Document Server

    De Loera, Jesús A; Vinzant, Cynthia

    2010-01-01

    The central curve of a linear program is an algebraic curve specified by linear and quadratic constraints arising from complementary slackness. It is the union of the various central paths for minimizing or maximizing the cost function over any region in the associated hyperplane arrangement. We determine the degree, arithmetic genus and defining prime ideal of the central curve, thereby answering a question of Bayer and Lagarias. These invariants, along with the degree of the Gauss image of the curve, are expressed in terms of the matroid of the input matrix. Extending work of Dedieu, Malajovich and Shub, this yields an instance-specific bound on the total curvature of the central path, a quantity relevant for interior point methods. The global geometry of central curves is studied in detail.

  20. FROM CENTRAL ASIA TO GREAT CENTRAL ASIA: THE GOALS AND ADJUSTMENTS OF U.S. CENTRAL ASIAN STRATEGY

    OpenAIRE

    Tian, Robert

    2009-01-01

    To penetrate and maintain peaceful development of the Central Asian region is a consistent goal of the United States for its international interests. With the 9/11 event as the baseline, since 2001 America's awareness of the strategic importance of Central Asia and the latter's weight in U.S. global strategy has been greatly changed. According to Charles Manes, the 9/11 terrorist attack enabled the U.S. to "discover Central Asia. As a result of this discovery the United States effectively gai...

  1. Report of the Central Tracking Group

    International Nuclear Information System (INIS)

    Issues involved in building a realistic central tracking system for a general-purpose 4π detector for the SSC are addressed. Such a central tracking system must be capable of running at the full design luminosity of 1033 cm-2s-1. Momentum measurement was required in a general-purpose 4π detector. Limitations on charged particle tracking detectors at the SSC imposed by rates and radiation damage are reviewed. Cell occupancy is the dominant constraint, which led us to the conclusion that only small cells, either wires or straw tubes, are suitable for a central tracking system at the SSC. Mechanical problems involved in building a central tracking system of either wires or straw tubes were studied, and our conclusion was that it is possible to build such a large central tracking system. Of course, a great deal of research and development is required. We also considered central tracking systems made of scintillating fibers or silicon microstrips, but our conclusion was that neither is a realistic candidate given the current state of technology. We began to work on computer simulation of a realistic central tracking system. Events from interesting physics processes at the SSC will be complex and will be further complicated by hits from out-of-time bunch crossings and multiple interactions within the same bunch crossing. Detailed computer simulations are needed to demonstrate that the pattern recognition and tracking problems can be solved

  2. XNAT Central: Open sourcing imaging research data.

    Science.gov (United States)

    Herrick, Rick; Horton, William; Olsen, Timothy; McKay, Michael; Archie, Kevin A; Marcus, Daniel S

    2016-01-01

    XNAT Central is a publicly accessible medical imaging data repository based on the XNAT open-source imaging informatics platform. It hosts a wide variety of research imaging data sets. The primary motivation for creating XNAT Central was to provide a central repository to host and provide access to a wide variety of neuroimaging data. In this capacity, XNAT Central hosts a number of data sets from research labs and investigative efforts from around the world, including the OASIS Brains imaging studies, the NUSDAST study of schizophrenia, and more. Over time, XNAT Central has expanded to include imaging data from many different fields of research, including oncology, orthopedics, cardiology, and animal studies, but continues to emphasize neuroimaging data. Through the use of XNAT's DICOM metadata extraction capabilities, XNAT Central provides a searchable repository of imaging data that can be referenced by groups, labs, or individuals working in many different areas of research. The future development of XNAT Central will be geared towards greater ease of use as a reference library of heterogeneous neuroimaging data and associated synthetic data. It will also become a tool for making data available supporting published research and academic articles. PMID:26143202

  3. Central black hole masses of galaxies

    Institute of Scientific and Technical Information of China (English)

    樊军辉

    2003-01-01

    In this paper, the stellar velocity dispersions in the host galaxies are used to estimate the central black hole masses for a sample of elliptical galaxies. We find that the central black hole masses are in the range of 10(5.5-9.5) M(○). Based on the estimated masses in this paper and those by Woo & Urry (2002) and the measured host galaxy absolute magnitude,a relation, log(MBH/M(○)) = -(0.25 ± 4.3 × 10-3)MR + (2.98 4 0.208) is found for central black hole mass and the host galaxy magnitude. Some discussions are presented.

  4. Central versus institutional self-archiving

    OpenAIRE

    Harnad, Stevan

    2006-01-01

    NIH's, PLoS's, the Wellcome Trust's and now the UK MRC's unreflective support for PubMed Central (PMC), a Central Repository (CR), as the locus for direct self-archiving by authors is very unfortunate for Institutional Repositories (IRs), for self-archiving, and for Open Access (OA) progress in general. Alma Swan has published key papers on both OA self-archiving policy and institutional versus central self-archiving (IRs vs. CRs) analysing the reasons. (a) Institutional self-archiving and ce...

  5. Searchability of central nodes in networks

    CERN Document Server

    Klemm, Konstantin

    2013-01-01

    Social networks are discrete systems with a large amount of heterogeneity among nodes (individuals). Measures of centrality aim at a quantification of nodes' importance for structure and function. Here we ask to which extent the most central nodes can be found by purely local search. We find that many networks have close-to-optimal searchability under eigenvector centrality, outperforming searches for degree and betweenness. Searchability of the strongest spreaders in epidemic dynamics tends to be substantially larger for supercritical than for subcritical spreading.

  6. Performance contracting in central government in Denmark

    DEFF Research Database (Denmark)

    Kristiansen, Mads Bøge

    2015-01-01

    This paper looks into performance contracting in Danish central government. Management by Objectives and Results (MBOR) was adopted in central government in Denmark during the 1980s and early 1990s. In 1991, performance contracts between parent ministries and their agencies were introduced in...... observed across central government agencies, when the content of the performance contracts is compared. This makes it interesting to examine how variation in the content of the performance contracts across agencies can be explained? Based on a broad theoretical framework in which variation in...

  7. China and Central Asian Energy Geopolitics

    Directory of Open Access Journals (Sweden)

    Zafar Javed

    2014-04-01

    Full Text Available China is immediate neighbour of Central Asian States and has very long history of engagement with the region. A brief history of Chinese engagementis discussed in given paper. China is world largest economy and dependent of imported oil and gas form different part of world and this oiland gas supply is expensive and vulnerable because of various reasons, therefore China is focusing on Central Asia as this region has vast amountof hydrocarbons. Chinese policies and strategies to grab Central Asian oil and gas are also examined in given paper.

  8. Miniaturized Airborne Imaging Central Server System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance computer-based electronic backend that...

  9. Miniaturized Airborne Imaging Central Server System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance-computer-based electronic backend that...

  10. Central Gulf of Alaska Rockfish Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The North Pacific Fishery Management Council adopted the Central Gulf of Alaska Rockfish Program (Rockfish Program) on June 14, 2010, to replace the expiring Pilot...

  11. Earthquakes in Central California, 1980-1984

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — There have been many earthquake occurrences in central California. This set of slides shows earthquake damage from the following events: Livermore, 1980, Coalinga,...

  12. Centrality measures for immunization of weighted networks

    Directory of Open Access Journals (Sweden)

    Mohammad Khansari

    2016-03-01

    Full Text Available Effective immunization of individual communities with minimal cost in vaccination has made great discussion surrounding the realm of complex networks. Meanwhile, proper realization of relationship among people in society and applying it to social networks brings about substantial improvements in immunization. Accordingly, weighted graph in which link weights represent the intensity and intimacy of relationships is an acceptable approach. In this work we employ weighted graphs and a wide variety of weighted centrality measures to distinguish important individuals in contagion of diseases. Furthermore, we propose new centrality measures for weighted networks. Our experimental results show that Radiality-Degree centrality is satisfying for weighted BA networks. Additionally, PageRank-Degree and Radiality-Degree centralities showmoreacceptable performance in targeted immunization of weighted networks.

  13. Legume Diversity Patterns in West Central Africa

    NARCIS (Netherlands)

    Estrella, de la M.; Mateo, M.A.; Wieringa, J.J.; Mackinder, B.; Munoz, J.

    2012-01-01

    Objectives - Species Distribution Models (SDMs) are used to produce predictions of potential Leguminosae diversity in West Central Africa. Those predictions are evaluated subsequently using expert opinion. The established methodology of combining all SDMs is refined to assess species diversity withi

  14. Early macroseismic maps in Central Europe

    Czech Academy of Sciences Publication Activity Database

    Kozák, Jan; Vaněk, Jiří

    2013-01-01

    Roč. 1, č. 2 (2013), s. 43-53. ISSN 2330-1740 Institutional support: RVO:67985530 Keywords : macroseismic maps * intensity scales * Central Europe * 19th century Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  15. Alluvial Boundary of California's Central Valley

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This digital dataset defines the extent of the alluvial deposits in the Central Valley of California and encompasses the contiguous Sacramento, San Joaquin, and...

  16. Random walk centrality in interconnected multilayer networks

    Science.gov (United States)

    Solé-Ribalta, Albert; De Domenico, Manlio; Gómez, Sergio; Arenas, Alex

    2016-06-01

    Real-world complex systems exhibit multiple levels of relationships. In many cases they require to be modeled as interconnected multilayer networks, characterizing interactions of several types simultaneously. It is of crucial importance in many fields, from economics to biology and from urban planning to social sciences, to identify the most (or the less) influent nodes in a network using centrality measures. However, defining the centrality of actors in interconnected complex networks is not trivial. In this paper, we rely on the tensorial formalism recently proposed to characterize and investigate this kind of complex topologies, and extend two well known random walk centrality measures, the random walk betweenness and closeness centrality, to interconnected multilayer networks. For each of the measures we provide analytical expressions that completely agree with numerically results.

  17. Development of the ZEUS Central Tracking Detector

    International Nuclear Information System (INIS)

    The design concept and development of the ZEUS Central Tracking Detector is described. This is a cylindrical drift chamber designed for track reconstruction, electron identification and event triggering in a high crossing-rate, high magnetic field environment. (author)

  18. Ablated tektite from the central Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Glass, B.P.; Chapman, D.R.; ShyamPrasad, M.

    ) australites found at Serpentine Lakes and Lake Wilson, Australia, and to some HMg microtektites found in deep-sea sediments from the central Indian Ocean. This discovery supports a previous conclusion that the Australasian tektite strewn field covers most...

  19. EXPLAINING TRAFFIC FLOW PATTERNS USING CENTRALITY MEASURES

    Directory of Open Access Journals (Sweden)

    Amila Jayasinghe

    2015-06-01

    Full Text Available This study examines the capability of centrality parameters of the road network to explain and predict traffic flow by types of vehicles. The case study was conducted in Colombo Metropolitan Area, Sri Lanka. Study used four centrality parameters i.e. connectivity, global integration, local integration and choice; and three analysis methods i.e. topological, metric and angular which introduced by space syntax analysis method to compute network centrality of the road network. Findings of this study stress that, (1 human beings perceive the space mostly from geometrical distance (topological and angular distance in comparison to metric distance. Further to this, it was found that angular distance is more powerful in global level whereas topological distance is more powerful in local level; (2 it is more appropriate to consider the multiple influences from multiple centrality parameters rather being confined to a single best parameter and influence of each parameter varies based on type of vehicles.

  20. Francis Crick, DNA, and the Central Dogma

    Science.gov (United States)

    Olby, Robert

    1970-01-01

    This essay describes how Francis Crick, ex-physicist, entered the field of biology and discovered the structure of DNA. Emphasis is upon the double helix, the sequence hypothesis, the central dogma, and the genetic code. (VW)

  1. The CMS central hadron calorimeter: Update

    International Nuclear Information System (INIS)

    The CMS central hadron calorimeter is a brass absorber/ scintillator sampling structure. We describe details of the mechanical and optical structure. We also discuss calibration techniques, and finally the anticipated construction schedule

  2. Random walk centrality in interconnected multilayer networks

    CERN Document Server

    Solé-Ribalta, Albert; Gómez, Sergio; Arenas, Alex

    2015-01-01

    Real-world complex systems exhibit multiple levels of relationships. In many cases they require to be modeled as interconnected multilayer networks, characterizing interactions of several types simultaneously. It is of crucial importance in many fields, from economics to biology and from urban planning to social sciences, to identify the most (or the less) influential nodes in a network using centrality measures. However, defining the centrality of actors in interconnected complex networks is not trivial. In this paper, we rely on the tensorial formalism recently proposed to characterize and investigate this kind of complex topologies, and extend two well known random walk centrality measures, the random walk betweenness and closeness centrality, to interconnected multilayer networks. For each of the measures we provide analytical expressions that completely agree with numerically results.

  3. NCPC Central Files Information System (CFIS)

    Data.gov (United States)

    National Capital Planning Commission — This dataset contains records from NCPC's Central Files Information System (CFIS), which is a comprehensive database of projects submitted to NCPC for design review...

  4. Central California 3 arc-second DEM

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 3-second Central California Elevation Grid provides bathymetric data in ASCII raster format of 3-second resolution in geographic coordinates. This grid is...

  5. Central Asian Snow Cover from Hydrometeorological Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Central Asian Snow Cover from Hydrometeorological Surveys data are based on observations made by personnel for three river basins: Amu Darya, Sir Darya, and...

  6. Central Station DHC Phase 1 feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, H.L.

    1992-03-01

    This project assisted a private real estate developer in technically assessing the feasibility of integrating a central DHC system into a proposed 72 acre area mixed-use Planned Development (Central Station) just south of the Chicago Central Business District (Loop). The technical assessment concluded that a district heating and cooling system for Central Station will be feasible, provided that a major anchor load can be connected to the system. The system conceived for the site employs a modular approach that adjusts production capacity to actual load growth. The design concept includes gas-fired boilers for heating, gas turbine driven chillers for base loading, electric motor driven chillers for peaking, steam turbines for peak power and back pressure operation, and chilled water storage. Energy will be supplied to the users in the form of steam or low temperature hot water for heating, and low temperature chilled water for cooling.

  7. Veterans Affairs Central Cancer Registry (VACCR)

    Data.gov (United States)

    Department of Veterans Affairs — The Veterans Affairs Central Cancer Registry (VACCR) receives and stores information on cancer diagnosis and treatment constraints compiled and sent in by the local...

  8. Staging Childhood Central Nervous System Embryonal Tumors

    Science.gov (United States)

    ... children. See the PDQ summary on Adult Central Nervous System Tumors Treatment for more information on the treatment of adults. There are different types of CNS embryonal tumors. Enlarge Anatomy of the inside of the brain, showing the ...

  9. 1999 Yellow River Aerial Photos, Central Wisconsin

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The 25-mile stretch of the Yellow River adjacent to the Necedah National Wildlife Refuge in Central Wisconsin provides valuable habitat to numerous species of...

  10. Initial TMX central-cell ICRH experiments

    International Nuclear Information System (INIS)

    Four topics are discussed in this report: the feasibility of applying ion cyclotron resonance heating (ICRH) in the TMX central cell, some applications of heating, the results of preliminary experiments, and plans for further ICRH experiments

  11. Asset prices, financial fragility, and central banking

    OpenAIRE

    Tymoigne, Éric

    2006-01-01

    The paper reviews the current literature on the subject in both the New Consensus and Post Keynesian frameworks. It shows that both approaches give to central banks a wrong goal (inflation, distribution, curbing speculation, and so on) and a wrong instrument (interest rate rule). The paper claims that central banks should focus their attention on maintaining financial stability and leave other problems to public institutions better suited for this task. In doing so they should develop new too...

  12. Central management of experimental data network

    OpenAIRE

    Meixner, Jaroslav

    2012-01-01

    The aim of this diploma thesis is design and implementation of experimantal data network central management in convergent network technology laboratory. This diploma thesis is devided into several chapters. Management network fundamentals are described in introduction. Actually used experimental network is analyzed in the second chapter. Design and implemantion of web modular information system are presented in third part. Solution of central management network system is summarised at the end...

  13. Role of Central Bank in Islamic Finance

    OpenAIRE

    Shaikh, Salman

    2009-01-01

    The rapid growth in Islamic finance industry urges us to not only look for alternatives in the Islamic commercial banking, but also focus on the regulator and its role and functions to enable it to work in conformity with Islamic principles. This study reviews limited, but precious academic literature on central banking and monetary management in an environment where Islamic finance is in vogue. Refinance ratio and Qard-e-Hasan ratio and Mudarabah between central bank and Islamic commercial b...

  14. Central diffractive resonance production at the LHC

    Science.gov (United States)

    Fiore, Roberto; Jenkovszky, Laszlo; Schicker, Rainer

    2016-07-01

    Central production of resonances resulting from the scattering of Pomerons in the central rapidity region of proton-proton scattering is studied. Estimates for relevant cross sections are presented. L.J. gratefully acknowledges an EMMI visiting Professorship at the University of Heidelberg for completion of this work. He is grateful to the organizers of this meeting for their hospitality and support. His work was supported also by DOMUS, Hungarian Academy of Sciences

  15. Focal lesions in the central nervous system

    International Nuclear Information System (INIS)

    This report reviews the animal and human studies currently in progress at LBL with heavy-ion beams to induce focal lesions in the central nervous system, and discusses the potential future prospects of fundamental and applied brain research with heavy-ion beams. Methods are being developed for producing discrete focal lesions in the central nervous system using the Bragg ionization peak to investigate nerve pathways and neuroendocrine responses, and for treating pathological disorders of the brain

  16. Hitherto unreported Agaricus species of Central India

    OpenAIRE

    MAHENDRA KUMAR RAI; ALKA KARWA

    2010-01-01

    Karwa A, Rai MK. 2010. Hitherto unreported Agaricus species of Central India. Nusantara Bioscience 2: 141-145. Melghat forest region from Central India was surveyed for occurrence of medicinal and culinary mushrooms during the years 2005-2008. Out of total 153 species, ten species of Agaricus were recorded from different localities. Of these, seven species namely Agaricus bitorquis, A. subrufescens, A. augustus, A. placomyces, A. essettei, A. basioanolosus and Agaricus sp. nov (a new species)...

  17. "Lessons from an Unconventional Central Banker"

    OpenAIRE

    Thorvald Grung Moe

    2013-01-01

    The global financial crisis has generated renewed interest in the 1951 Treasury - Federal Reserve Accord and its lessons for central bank independence. A broader interpretation of the Accord and of Marriner S. Eccles's role at the Federal Reserve should teach central bankers that independence can be crucial for fighting inflation, but also encourage them to be more supportive of government efforts to fight deflation and mass unemployment.

  18. Central Serous Chorioretinopathy after Solar Eclipse Viewing

    OpenAIRE

    Allie Lee; Timothy Lai

    2010-01-01

    Purpose: To report a case of central serous chorioretinopathy after solar eclipse viewing. Case Report: A middle-age man developed a sudden-onset unilateral scotoma after viewing a partial solar eclipse in Hong Kong. Fundus examination, fluorescein angiography, and optical coherence tomography showed features compatible with central serous chorioretinopathy. The patient was managed conservatively and reevaluated periodically. Serial optical coherence tomographic evaluations demonstrated a...

  19. Central Institute for Nuclear Research (1956 - 1979)

    International Nuclear Information System (INIS)

    The Central Institute for Nuclear Research (ZfK) of the Academy of Sciences of the GDR is presented. This first overall survey covers the development of the ZfK since 1956, the main research activities and results, a description of the departments responsible for the complex implementation of nuclear research, the social services for staff and the activities of different organizations in the largest central institute of the Academy of Sciences of the GDR. (author)

  20. Transient central diabetes insipidus following ischemic stroke

    Directory of Open Access Journals (Sweden)

    Muthukrishnan Jayaraman

    2013-01-01

    Full Text Available Central Diabetes Insipidus (CDI following ischemic infarction of the brain has been described as a rare presentation. Posterior pituitary ischemia has also been postulated as a possible cause of idiopathic CDI. We encountered a young male with bilateral extensive ischemic infarction sustained at high altitude, who had transient polyuria due to central diabetes insipidus, requiring desmopressin therapy. DI completely resolved during the course of his neurological recovery.

  1. Transient central diabetes insipidus following ischemic stroke

    OpenAIRE

    Muthukrishnan Jayaraman; Sandeep Kumar; Ahmad, F. M. H.

    2013-01-01

    Central Diabetes Insipidus (CDI) following ischemic infarction of the brain has been described as a rare presentation. Posterior pituitary ischemia has also been postulated as a possible cause of idiopathic CDI. We encountered a young male with bilateral extensive ischemic infarction sustained at high altitude, who had transient polyuria due to central diabetes insipidus, requiring desmopressin therapy. DI completely resolved during the course of his neurological recovery.

  2. Transient central diabetes insipidus following ischemic stroke.

    Science.gov (United States)

    Jayaraman, Muthukrishnan; Kumar, Sandeep; Ahmad, F M H

    2013-10-01

    Central Diabetes Insipidus (CDI) following ischemic infarction of the brain has been described as a rare presentation. Posterior pituitary ischemia has also been postulated as a possible cause of idiopathic CDI. We encountered a young male with bilateral extensive ischemic infarction sustained at high altitude, who had transient polyuria due to central diabetes insipidus, requiring desmopressin therapy. DI completely resolved during the course of his neurological recovery. PMID:24251140

  3. Central regions of keloids are severely ischaemic.

    Science.gov (United States)

    Touchi, Ryoma; Ueda, Koichi; Kurokawa, Norifumi; Tsuji, Motomu

    2016-02-01

    We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic. PMID:26794626

  4. Central Asia's comparative advantage in international trade

    OpenAIRE

    Lücke, Matthias; Rothert, Jacek

    2006-01-01

    This paper outlines a strategy for identifying the pattern of Central Asia’s comparative advantage in international trade, based on factor prices and transport costs, historical production patterns, and recent trends in the geographical and product composition of Central Asian trade. The paper focuses on Kazakhstan, the Kyrgyz Republic, Tajikistan, and Uzbekistan, along with Azerbaijan and Mongolia. A country’s comparative advantage cannot be determined at the level of individual industries o...

  5. Association and Centrality in Criminal Networks

    DEFF Research Database (Denmark)

    Petersen, Rasmus Rosenqvist

    analyze the structural richness required to model and investigate criminal network entities and their associations. We demonstrate a need to rethink entity associations with one specific case (inspired by \\textit{The Wire}, a tv series about organized crime in Baltimore, United States) and corroborated by...... three of these associations and extend and test two centrality measures using CrimeFighter Investigator, a novel tool for criminal network investigation. Our findings show that the extended centrality measures offer new insights into criminal networks....

  6. Central Exams Improve Educational Performance: International Evidence

    OpenAIRE

    Wößmann, Ludger

    2002-01-01

    International comparative studies of student performance have initiated political discussions in countries all over the world on how to improve the educational achievement of students. The empirical evidence suggests that central exams help to achieve higher student performance. Central exams direct the incentives of all educational actors towards furthering students’ knowledge. By providing the education system with performance information they improve the monitoring of students, teachers, s...

  7. A handbook for solar central receiver design

    Energy Technology Data Exchange (ETDEWEB)

    Falcone, P.K.

    1986-12-01

    This Handbook describes central receiver technology for solar thermal power plants. It contains a description and assessment of the major components in a central receiver system configured for utility scale production of electricity using Rankine-cycle steam turbines. It also describes procedures to size and optimize a plant and discussed examples from recent system analyses. Information concerning site selection criteria, cost estimation, construction, and operation and maintenance is also included, which should enable readers to perform design analyses for specific applications.

  8. Entrapment of guidewire during central venous catheterization

    Directory of Open Access Journals (Sweden)

    Tarun S.

    2016-07-01

    Full Text Available Central venous catheterization (CVC is common in the setting of ICU for various reasons like monitoring of CVP, fluid administration and vasopressor or drug infusions. Guidewires are routinely used in the Seldinger technique during central venous catheter placement CVC placement is not innocuous as numerous complications may occur, with varying frequency and severity. [Int J Res Med Sci 2016; 4(7.000: 3080-3081

  9. Peritoneal dissemination from central neurocytoma: case report

    OpenAIRE

    Coelho Neto Maurício; Ramina Ricardo; Meneses Murilo Sousa de; Arruda Walter Oleschko; Milano Jerônimo Buzetti

    2003-01-01

    OBJECTIVE: central neurocytoma is a low grade tumor of neuroglial origin and a relatively new histological entity. Only a few cases have been reported and its biological behavior is still uncertain. Some cases have shown an aggressive behavior (local recurrence, malignant dedifferentiation or CSF dissemination) and challenged the initial view of its relative benignity. A case of central neurocytoma with peritoneal dissemination is presented. CASE: a six years-old boy with recurrent neurocytom...

  10. Central structure preservation of the reversal sign

    International Nuclear Information System (INIS)

    We report serial changes of central structure preservation of the reversal sign in a case of child abuse. The serial CT images show that the relatively spared attenuation at the basal ganglia, thalami, and posterior fossa develops before the occurrence of transtentorial herniation. This finding makes the theory that central preservation of the reversal sign is due to pressure relief after transtentorial herniation less convincible. (orig.)

  11. Central structure preservation of the reversal sign

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C.J. [Dept. of Diagnostic Radiology, Chang Gung Memorial Hospital, Taipei (Taiwan)

    1999-12-01

    We report serial changes of central structure preservation of the reversal sign in a case of child abuse. The serial CT images show that the relatively spared attenuation at the basal ganglia, thalami, and posterior fossa develops before the occurrence of transtentorial herniation. This finding makes the theory that central preservation of the reversal sign is due to pressure relief after transtentorial herniation less convincible. (orig.)

  12. Yes, we need a central bank

    OpenAIRE

    Hanif, Muhammad Nadim

    2002-01-01

    The financial system of a country comprises entities engaged in transactions involving financial instruments in money, capital, and foreign exchange markets. This sector has strong linkages with other sectors of the economy like external, fiscal and real sectors. The apex financial institution in every country is its Central Bank and the State Bank of Pakistan functions as our Central Bank. Section 9A. 1. of the State Bank of Pakistan Act 1956 shoulders the function of securing the soundness ...

  13. Community centrality and social science research.

    Science.gov (United States)

    Allman, Dan

    2015-12-01

    Community centrality is a growing requirement of social science. The field's research practices are increasingly expected to conform to prescribed relationships with the people studied. Expectations about community centrality influence scholarly activities. These expectations can pressure social scientists to adhere to models of community involvement that are immediate and that include community-based co-investigators, advisory boards, and liaisons. In this context, disregarding community centrality can be interpreted as failure. This paper considers evolving norms about the centrality of community in social science. It problematises community inclusion and discusses concerns about the impact of community centrality on incremental theory development, academic integrity, freedom of speech, and the value of liberal versus communitarian knowledge. Through the application of a constructivist approach, this paper argues that social science in which community is omitted or on the periphery is not failed science, because not all social science requires a community base to make a genuine and valuable contribution. The utility of community centrality is not necessarily universal across all social science pursuits. The practices of knowing within social science disciplines may be difficult to transfer to a community. These practices of knowing require degrees of specialisation and interest that not all communities may want or have. PMID:26440071

  14. Central alarm system replacement in NPP Krsko

    International Nuclear Information System (INIS)

    Current NPP Krsko central alarm system consists of three main segments. Main Control Board alarm system (BETA 1000), Ventilation Control Board alarm system (BETA 1000) and Electrical Control Board alarm system (BETA 1100). All sections are equipped with specific BetaTone audible alarms and silence, acknowledge as well as test push buttons. The main reason for central alarm system replacement is system obsolescence and problems with maintenance, due to lack of spare parts. Other issue is lack of system redundancy, which could lead to loss of several Alarm Light Boxes in the event of particular power supply failure. Current central alarm system does not provide means of alarm optimization, grouping or prioritization. There are three main options for central alarm system replacement: Conventional annunciator system, hybrid annunciator system and advanced alarm system. Advanced alarm system implementation requires Main Control Board upgrade, integration of process instrumentation and plant process computer as well as long time for replacement. NPP Krsko has decided to implement hybrid alarm system with patchwork approach. The new central alarm system will be stand alone, digital, with advanced filtering and alarm grouping options. Sequence of event recorder will be linked with plant process computer and time synchronized with redundant GPS signal. Advanced functions such as link to plant procedures will be implemented with plant process computer upgrade in outage 2006. Central alarm system replacement is due in outage 2004.(author)

  15. Health challenges in Kazakhstan and Central Asia.

    Science.gov (United States)

    Adambekov, Shalkar; Kaiyrlykyzy, Aiym; Igissinov, Nurbek; Linkov, Faina

    2016-01-01

    The Central Asian region, which encompasses Kazakhstan, Uzbekistan, Tajikistan, Turkmenistan and Kyrgyzstan, is an interesting geographic region with a rich history dating back to the Silk Road, Mongol conquests and expansion of the Russian Empire. However, from a public health viewpoint, the Central Asian region is under-investigated, and many public health challenges exist, as countries of Central Asia inherited the centralised medical systems practiced in the Soviet Union, and are currently undergoing rapid transitions. A large number of low and middle-income countries around the world, including countries of Central Asia, face a double burden of chronic and infectious disease. This essay focuses on the exploration of the most important public health challenges in the Central Asian region, including limited scientific productivity, the double burden of chronic and infectious disease, the need for healthcare reform and the reduction in care variation. Central Asia has a large number of medical schools, medical centres, and emerging research institutes that can be used to foster a change in medical and public health practice in the region. PMID:26254293

  16. Determinants of Central Adiposity among Iranian Population

    Directory of Open Access Journals (Sweden)

    Leila Azadbakht

    2013-03-01

    Full Text Available Background: Central obesity is one of the major public health problems. Recent studies have indicated that body fat distribution would be important in general health. Materials and Methods: The present study is a review of several studies which discuss the contributing factors of abdominal obesity, particulary in Iran. This study reviews 34 cross-sectional and interventional studies, which have been comducted during 1995-2012 and issued in English language. PubMed search engine and the related keywords were used to search the papers.Results: Breakfast skipping and also the sleep duration as well as the quality of diet are also associated with central adiposity. Dietary diversity score among Iranians can be related to abdominal adiposity. Fastfood consumption can increase the risk of central adiposity among young Iranian population. Red meat intake and food source of trans fat can increase the risk of central adiposity. Low quality diet with low amount of nutrients can increase the risk of central adiposity. Conclusion: Some behaviours such as sleep duration and eating breakfast can be associated with central adiposity among Iranians. Diet quality and dietary diversity score is also associated with this problem among Iranians.

  17. Central Banker Contracts, Incomplete Information, and Monetary Policy Surprises: In Search of a Selfish Central Banker?

    OpenAIRE

    Georgios E. Chortareas; Miller, Stephen M.

    2002-01-01

    Approaching monetary policy as a principal agent problem provides a useful framework for interpreting alternative delegation schemes. In this paper, we consider the effectiveness of central banker incentive schemes when the principal delegates monetary policy through contracts but remains uncertain about the central banker's responsiveness to such schemes. We adopt a simple principal-agent model and assume that the central banker's trade-off between social welfare and the incentive scheme is ...

  18. Market Information and Signaling in Central Bank Operations, or, How Often Should a Central Bank Intervene?

    OpenAIRE

    International Monetary Fund

    1997-01-01

    A central bank must decide on the frequency with which it will conduct open market operations and the variability in short-term money market that it will allow. The paper shows how the optimal operating procedure balances the value of attaining an immediate target and broadcasting the central bank's intentions against the informational advantages to the central bank of allowing the free play of market forces to reveal more of the information available to market participants.

  19. 21 CFR 1305.24 - Central processing of orders.

    Science.gov (United States)

    2010-04-01

    ... order with all linked records on the central computer system. (b) A company that has central processing... or more registered locations and maintains a central processing computer system in which orders are... the company owns and operates....

  20. Re-introduction of globally threatened Arabian Gazelles Gazella Arabica (Pallas, 1766 (Mammalia: Bovidae in fenced protected area in central Saudi Arabia

    Directory of Open Access Journals (Sweden)

    M.Z. Islam

    2014-07-01

    Full Text Available The Arabian Gazelle is a globally threatened antelope (Vulnerable in Saudi Arabia. Small relict populations remain in limited areas, while historically Arabian Gazelles occurred in Mahazat as-Sayd protected area in central Saudi Arabia but were exterminated by anthropogenic and other pressures, including habitat loss and hunting. Important habitat has been lost to agricultural developments, fencing of pasture for livestock and the construction of human settlements and roads. The reintroduction of Arabian Gazelles was undertaken in Mahazat during 2011-2014 to bring back this locally extinct species study its ecology and biology in a fenced protected area. We released a total of 49 (12 males, 37 females animals. A year after release animals started breeding and six calves have been recorded so far with more to come. The gazelles prefer to use more rocky areas where shrubs and acacia trees occur in the reserve, and do not move long distances except for one individual that moved more than 50km. Mahazat is fenced, which prevents local people from entering the reserve to poach or otherwise disturb animals. Management lessons include the need for continued monitor-ing of reintroduced populations. Interactions between Arabian and Sand Gazelles (Gazella subgutturosa marica and Arabian Oryx (Oryx leucoryx were also studied.

  1. Crystal Structure, Chemical Bonding and Magnetism Studies for Three Quinary Polar Intermetallic Compounds in the (Eu1−xCax9In8(Ge1−ySny8 (x = 0.66, y = 0.03 and the (Eu1−xCax3In(Ge3−ySn1+y (x = 0.66, 0.68; y = 0.13, 0.27 Phases

    Directory of Open Access Journals (Sweden)

    Hyein Woo

    2015-04-01

    Full Text Available Three quinary polar intermetallic compounds in the (Eu1−xCax9In8(Ge1−ySny8 (x = 0.66, y = 0.03 and the (Eu1−xCax3In(Ge3-ySn1+y (x = 0.66, 0.68; y = 0.13, 0.27 phases have been synthesized using the molten In-metal flux method, and the crystal structures are characterized by powder and single-crystal X-ray diffractions. Two orthorhombic structural types can be viewed as an assembly of polyanionic frameworks consisting of the In(Ge/Sn4 tetrahedral chains, the bridging Ge2 dimers, either the annulene-like “12-membered rings” for the (Eu1−xCax9In8(Ge1−ySny8 series or the cis-trans Ge/Sn-chains for the (Eu1−xCax3In(Ge3−ySn1+y series, and several Eu/Ca-mixed cations. The most noticeable difference between two structural types is the amount and the location of the Sn-substitution for Ge: only a partial substitution (11% occurs at the In(Ge/Sn4 tetrahedron in the (Eu1−xCax9In8(Ge1−ySny8 series, whereas both a complete and a partial substitution (up to 27% are observed, respectively, at the cis-trans Ge/Sn-chain and at the In(Ge/Sn4 tetrahedron in the (Eu1−xCax3In(Ge3−ySn1+y series. A series of tight-binding linear muffin-tin orbital calculations is conducted to understand overall electronic structures and chemical bonding among components. Magnetic susceptibility measurement indicates a ferromagnetic ordering of Eu atoms below 5 K for Eu1.02(1Ca1.98InGe2.87(1Sn1.13.

  2. Estimating the Budgets of Nutrients for Phytoplankton Bloom in the Central Yellow Sea Using a Modified Lower Tropic Ecosystem Model

    Institute of Scientific and Technical Information of China (English)

    YUAN Chengyi; WANG Yuheng; WEI Hao

    2014-01-01

    A modified lower trophic ecosystem model (NEMURO) is coupled with a three-dimensional hydrodynamic model for an application in the central Yellow Sea. The model is used to simulate the horizontal distributions and annual cycles of chlorophyll-a and nutrients with results consistent with historical observations. Generally, during the winter background and spring bloom periods, the exchange with neighboring waters constitutes the primary sources of nutrients. Howerver, during the winter background period, the input of silicate from the layer deeper than 50 m is the most important source that contributes up to 60%to the total sources. Dur-ing the spring bloom period, the transport across the thermocline makes significant contribution to the input of phosphate and silicate. During the post spring bloom period, the relative contribution of relevant processes varies for different nutrients. For ammonium, atmospheric deposition, excretion of zooplankton and decomposition of particulate and dissolved nitrogen make similar contributions. For phosphate and silicate, the dominant input is the transport across the thermocline, accounting for 62% and 68% of the total sources, respectively. The N/P ratio averaged annually and over the whole southern Yellow Sea is up to 51.8, indicating the potential of P limitation in this region. The important influence of large scale sea water circulation is revealed by both the estimated fluxes and the corresponding N/P ratio of nutrients across a section linking the northeastern bank of the Changjiang River and Cheju Island. During the winter background period, the input of nitrate, ammonium, phosphate and silicate by the Yellow Sea Warm Current is estimated to be 4.6×1010, 2.3×1010, 2.0×109 and 1.2×1010 mol, respectively.

  3. Central depression of nuclear charge density distribution

    International Nuclear Information System (INIS)

    The center-depressed nuclear charge distributions are investigated with the parametrized distribution and the relativistic mean-field theory, and their corresponding charge form factors are worked out with the phase shift analysis method. The central depression of nuclear charge distribution of 46Ar and 44S is supported by the relativistic mean-field calculation. According to the calculation, the valence protons in 46Ar and 44S prefer to occupy the 1d3/2 state rather than the 2s1/2 state, which is different from that in the less neutron-rich argon and sulfur isotopes. As a result, the central proton densities of 46Ar and 44S are highly depressed, and so are their central charge densities. The charge form factors of some argon and sulfur isotopes are presented, and the minima of the charge form factors shift upward and inward when the central nuclear charge distributions are more depressed. Besides, the effect of the central depression on the charge form factors is studied with a parametrized distribution, when the root-mean-square charge radii remain constant.

  4. Generation of central exclusive final states

    CERN Document Server

    Lönnblad, Leif

    2016-01-01

    We present a scheme for the generation of central exclusive final states in the Pythia 8 program. The implementation allows for the investigation of higher order corrections to such exclusive processes as approximated by the initial-state parton shower in Pythia 8. To achieve this, the spin and colour decomposition of the initial-state shower has been worked out, in order to determine the probability that a partonic state generated from an inclusive sub-process followed by a series of initial-state parton splittings can be considered as an approximation of an exclusive colour- and spin-singlet process. We use our implementation to investigate effects of parton showers on some examples of central exclusive processes, and find sizeable effects on di-jet production, while the effects on e.g. central exclusive Higgs production are minor.

  5. Central functions of the orexinergic system

    Institute of Scientific and Technical Information of China (English)

    Xiao-Yang Zhang; Lei Yu; Qian-Xing Zhuang; Jing-Ning Zhu; Jian-Jun Wang

    2013-01-01

    The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus.However,these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system.It is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions,including feeding,energy homeostasis,the sleep/wake cycle,reward,addiction,and neuroendocrine,as well as motor control.Moreover,the absence of orexin results in narcolepsy-cataplexy,a simultaneous somatic and non-somatic dysfunction.In this review,we summarize these central functions of the orexinergic system and associated diseases,and suggest that this system may hold a key position in somatic-non-somatic integration.

  6. The Fermilab Central Computing Facility architectural model

    International Nuclear Information System (INIS)

    The goal of the current Central Computing Upgrade at Fermilab is to create a computing environment that maximizes total productivity, particularly for high energy physics analysis. The Computing Department and the Next Computer Acquisition Committee decided upon a model which includes five components: an interactive front end, a Large-Scale Scientific Computer (LSSC, a mainframe computing engine), a microprocessor farm system, a file server, and workstations. With the exception of the file server, all segments of this model are currently in production: a VAX/VMS Cluster interactive front end, an Amdahl VM computing engine, ACP farms, and (primarily) VMS workstations. This presentation will discuss the implementation of the Fermilab Central Computing Facility Architectural Model. Implications for Code Management in such a heterogeneous environment, including issues such as modularity and centrality, will be considered. Special emphasis will be placed on connectivity and communications between the front-end, LSSC, and workstations, as practiced at Fermilab. 2 figs

  7. Correcting intermittent central suppression improves binocular marksmanship.

    Science.gov (United States)

    Hussey, Eric S

    2007-04-01

    Intermittent central suppression (ICS) is a defect in normal binocular (two-eyed) vision that causes confusion in visual detail. ICS is a repetitive intermittent loss of visual sensation in the central area of vision. As the central vision of either eye "turns on and off", aiming errors in sight can occur that must be corrected when both eyes are seeing again. Any aiming errors in sight might be expected to interfere with marksmanship during two-eyed seeing. We compared monocular (one-eyed, patched) and binocular (two-eyed) marksmanship with pistol shooting with an Army ROTC cadet before and after successful therapy for diagnosed ICS. Pretreatment, monocular marksmanship was significantly better than binocular marksmanship, suggesting defective binocularity reduced accuracy. After treatment for ICS, binocular and monocular marksmanship were essentially the same. Results confirmed predictions that with increased visual stability from correcting the suppression, binocular and monocular marksmanship accuracies should merge. PMID:17484315

  8. Estimation for large non-centrality parameters

    Science.gov (United States)

    Inácio, Sónia; Mexia, João; Fonseca, Miguel; Carvalho, Francisco

    2016-06-01

    We introduce the concept of estimability for models for which accurate estimators can be obtained for the respective parameters. The study was conducted for model with almost scalar matrix using the study of estimability after validation of these models. In the validation of these models we use F statistics with non centrality parameter τ =‖λ/‖2 σ2 when this parameter is sufficiently large we obtain good estimators for λ and α so there is estimability. Thus, we are interested in obtaining a lower bound for the non-centrality parameter. In this context we use for the statistical inference inducing pivot variables, see Ferreira et al. 2013, and asymptotic linearity, introduced by Mexia & Oliveira 2011, to derive confidence intervals for large non-centrality parameters (see Inácio et al. 2015). These results enable us to measure relevance of effects and interactions in multifactors models when we get highly statistically significant the values of F tests statistics.

  9. Retail Market Structure Development in Central Europe

    Directory of Open Access Journals (Sweden)

    Martin Machek

    2012-12-01

    Full Text Available This article is analyzing the trends and development in the retailing sector in Central Europe, namely in the Czech Republic, Hungary, Poland and Slovakia. These markets serve about 63 million inhabitants. The retail industry in Central Europe has changed dramatically in the last two decades, and has become a model for successful transformation of emerging markets. The retail market is highly concentrated and dominated by Western European retail chains. International retail chains are using all formats of modern distribution. This article is focusing on the development of hypermarkets, supermarkets and discount stores. Due to the international retail chains, Central European countries benefit from a dense network of modern shopping places; the intense competition of highly productive retailers contributes to the lower level of inflation rate because of the so-called Wal-Mart Effect. The constant pressure on prices influences the marketing strategies of both retailers and suppliers.

  10. District Central Office Leadership as Teaching: How Central Office Administrators Support Principals' Development as Instructional Leaders

    Science.gov (United States)

    Honig, Meredith I.

    2012-01-01

    Purpose: Research on educational leadership underscores the importance of principals operating as instructional leaders and intensive job-embedded supports for such work; this research also identifies central office staff as key support providers. However, it teaches little about what central office staff do when they provide such support and how…

  11. 75 FR 14436 - Ameren Corporation, Illinois Power Company, Central Illinois Light Company, Central Illinois...

    Science.gov (United States)

    2010-03-25

    ... Energy Regulatory Commission Ameren Corporation, Illinois Power Company, Central Illinois Light Company, Central Illinois Public Service Company, Ameren Energy Resources Company, LLC, AmerenEnergy Resources Generating Company; Notice of Filing March 18, 2010. Take notice that on March 15, 2010, Ameren...

  12. The Crisis And Central Bank Reaction

    Directory of Open Access Journals (Sweden)

    Silviu CERNA

    2009-05-01

    Full Text Available The world economy is in the face of the strongest crisis of the last seventy years. This crisis is still ongoing, but authorities in many countries have already taken a series of measures to mitigate the effects. In this fight, the central banks are the first line. It is still too early to draw any lessons from the events taking place, but a reflection "sine ira et studio" over this experience is already possible. This paper aims to analyze this experience through the policies implemented by central banks to cope with the crisis.

  13. Central helium density measurements in PLT

    International Nuclear Information System (INIS)

    The central helium density in PLT has been deduced from measurements of the ratio of d-3He to d-d fusion reactions during deuterium neutral beam injection. The inward transport time for 3He puffed at the edge plasma was 10 → 30 msec. The decay time of the central 3He density increased with electron density, varying from 0.3 sec to greater than 1.0 sec over the density range of (1 → 5) x 1013 cm-3

  14. Progress in ATLAS central solenoid magnet

    CERN Document Server

    Yamamoto, A; Makida, Y; Tanaka, K; Haruyama, T; Yamaoka, H; Kondo, T; Mizumaki, S; Mine, S; Wada, K; Meguro, S; Sotoki, T; Kikuchi, K; ten Kate, H H J

    2000-01-01

    The ATLAS central solenoid magnet is being developed to provide a magnetic field of 2 Tesla in the central tracking volume of the ATLAS detector under construction at the CERN/LHC project. The solenoid coil design features high-strength aluminum stabilized superconductor to make the coil thinnest while maintaining its stability and the pure-aluminum strip technique for quench protection and safety. The solenoid coil is installed in a common cryostat with the LAr calorimeter in order to minimize the cryostat wall. A transparency of 0.66 radiation length is achieved with these integrated efforts. The progress in the solenoid coil fabrication is reported. (8 refs).

  15. MRI of central nervous system anomalies

    International Nuclear Information System (INIS)

    MRI was very useful in the evaluation of congenital anomalies of central nervous system as well as other nervous system disease with three-dimensional spatial resolution. We had experienced MRI of central nervous system anomalies, demonstrated characterisitic findings in each anomaly. MRI is useful to observe the coronal, horizontal and sagittal images of the brain and spinal cord in order to discuss the etiological mechanisms of spinal dysraphysm and its associated anomalies. In case of spina bifida cystica MRI was available to decide operative indication for radical operation and tetherd cord developed from postoperative scar or accompanied intraspinal lesions. (author)

  16. MRI of central nervous system anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Izawa, M.; Oikawa, A.; Matoba, A.

    1987-05-01

    MRI was very useful in the evaluation of congenital anomalies of central nervous system as well as other nervous system disease with three-dimensional spatial resolution. We had experienced MRI of central nervous system anomalies, demonstrated characterisitic findings in each anomaly. MRI is useful to observe the coronal, horizontal and sagittal images of the brain and spinal cord in order to discuss the etiological mechanisms of spinal dysraphysm and its associated anomalies. In case of spina bifida cystica MRI was available to decide operative indication for radical operation and tetherd cord developed from postoperative scar or accompanied intraspinal lesions.

  17. Metabolic syndrome and central retinal artery occlusion

    OpenAIRE

    Kosanović-Jaković Natalija; Petrović Lidija; Risimić Dijana; Milenković Svetislav; Matić Danica

    2005-01-01

    Background. The accumulation of risk factors for central retinal artery occlusion can be seen in a single person and might be explained by the metabolic syndrome. Case report. We presented the case of a 52-year-old man with no light perception in his right eye. The visual loss was monocular and painless, fundoscopy showed central retinal artery occlusion and the laboratory investigation showed the raised erythrocyte sedimentation rate of 105 mm/h and the raised C-reactive protein of 22 mg/l. ...

  18. Probabilistic seismic hazard assessment for Central Asia

    OpenAIRE

    Shahid Ullah; Dino Bindi; Marco Pilz; Laurentiu Danciu; Graeme Weatherill; Elisa Zuccolo; Anatoly Ischuk; Natalya N. Mikhailova; Kanat Abdrakhmatov; Stefano Parolai

    2015-01-01

    Central Asia is one of the seismically most active regions in the world. Its complex seismicity due to the collision of the Eurasian and Indian plates has resulted in some of the world’s largest intra-plate events over history. The region is dominated by reverse faulting over strike slip and normal faulting events. The GSHAP project (1999), aiming at a hazard assessment on a global scale, indicated that the region of Central Asia is characterized by peak ground accelerations for 10% probabili...

  19. Solitary median maxillary central incisor (SMMCI) syndrome

    OpenAIRE

    Hall Roger K

    2006-01-01

    Abstract Solitary median maxillary central incisor syndrome (SMMCI) is a complex disorder consisting of multiple, mainly midline defects of development resulting from unknown factor(s) operating in utero about the 35th–38th day(s) from conception. It is estimated to occur in 1:50,000 live births. Aetiology is uncertain. Missense mutation in the SHH gene (I111F) at 7q36 may be associated with SMMCI. The SMMCI tooth differs from the normal central incisor, in that the crown form is symmetric; i...

  20. Centralized rehabilitation after servere traumatic brain injury

    DEFF Research Database (Denmark)

    Engberg, Aase Worså; Liebach, Annette; Nordenbo, Annette Mosbæk

    2006-01-01

    OBJECTIVES: To present results from the first 3 years of centralized subacute rehabilitation after very severe traumatic brain injury (TBI), and to compare results of centralized versus decentralized rehabilitation. MATERIAL AND METHODS: Prospectively, the most severely injured group of adults from...... an uptake area of 2.4 million in Denmark were included at admission to a regional brain injury unit (BIU), on average 19 days after injury. Patients in the retrospective study used for comparison were randomly chosen from the national hospital register. RESULTS AND CONCLUSIONS: Out of 117 patients in...

  1. Church Orientations in Central and Eastern Europe

    Science.gov (United States)

    Laužikas, Rimvydas

    The objective of this case study is to discuss church orientation in Central and Eastern Europe. Due to its geographical situation, this region is a specific part of European cultural space: it is remote from the main cultural centers, it was the last to adopt Christianity, and it experienced intensive interactions with Byzantine culture. Therefore, we can assess church orientation in Central and Eastern Europe as a tradition affected by multicultural interactions and in which there is an interlacement of Catholicism from Western Europe, Byzantinism, local pagan faiths and, in part, the ideas of conception of geographical space of the Jews, Karaites, and Muslims.

  2. Simulating central forces in the classroom

    CERN Document Server

    Aguirregabiria, Juan M

    2015-01-01

    We describe the easy to customize and extend open source Java program Central force workbench that can be used in the classroom to simulate the motion of a particle (or a two-body system) under central forces. It may be useful to illustrate problems in which the analytical solution is not available as well as to help students to grasp a more intuitive understanding of the main features of this kind of problem and to realize the exceptional nature of the particular case of Newtonian (and harmonic) forces. We also include some suggestions on how to use the program as a pedagogical tool.

  3. A Study on Water Saving Irrigation in Sandy Slope -Taking Nanj ing Garden in the Eighth Garden Expo of Jiangsu Province as an Example%沙质坡地节水浇灌研究--以江苏省第八届园博会南京园为例

    Institute of Scientific and Technical Information of China (English)

    尹伟; 潘良

    2014-01-01

    归纳了绿地浇灌的主要方式,提出了园林绿化节水浇灌的主要思路。针对沙质坡地节水浇灌问题,提出自动循环喷灌的技术方法。最后以江苏省第八届园博会南京园为例,详细介绍了南京园沙质坡地绿化节水浇灌的具体应用。%The paper summarizes the main modes of irrigation,and the main ideas of water-sav-ing irrigation in garden landscape.It also puts forward the cyclic irrigation technology to settle the problems of water-saving irrigation in the sandy slope.Finally,taking Nanjing Garden in the eighth Garden Expo of Jiangsu province as an example,it introduces in detail the concrete appli-cation of greening water-saving irrigation in the sandy slope of Nanjing Garden.

  4. Central Endoscopy Reading in Inflammatory Bowel Diseases.

    Science.gov (United States)

    Panés, Julián; Feagan, Brian G; Hussain, Fez; Levesque, Barrett G; Travis, Simon P

    2016-09-01

    Endoscopic assessment of the presence and severity of endoscopic lesions has become an essential part of clinical trials in ulcerative colitis and Crohn's disease, for both patient eligibility and outcome measures. Variability in lesion interpretation between and within observers and the potential bias of local investigators in patient assessment have long been recognized. This variability can be reduced, although not completely removed, by independent evaluation of the examinations by experienced off-site (central) readers, properly trained in regard to lesion definition and identification, that should be removed from direct patient contact and blinded to any other clinical or study data. Adding endoscopic demonstration of active disease to eligibility criteria has the potential to reduce placebo response rates, whereas in outcome assessment it has the potential to provide a more precise estimation of the treatment effect, increasing the efficiency of the study. Central endoscopy reading is still at the beginning of its development, and the paradigms of central reading need refinement in terms of the number of readers, the process by which a final score is assigned, the selection and sequence of central readers, and the endoscopic indices of choice. PMID:27604978

  5. The Marstal Central Solar Heating Plant

    DEFF Research Database (Denmark)

    Heller, Alfred; Jochen, Dahm

    1999-01-01

    The central solar heating plant in Marstal is running since 1996 and has been monitored since. The resulting data from the plant is analysed and the plant performance evaluated. A TRNSYS-model (computersimulation) id prepared and validated based on the measured data from the plant. Acceptable good...

  6. Imaging of the fetal central nervous system

    NARCIS (Netherlands)

    Pistorius, L.R.

    2008-01-01

    Introduction : Ultrasound and MR imaging of the fetal central nervous system (CNS) develop at an ever-increasing rate. Theoretically, the two modalities should be synergistic, but a literature review revealed the difficulties of determining the merit of either technique and revealed gaps in our know

  7. Gabapentin inhibits central sensitization during migraine

    Institute of Scientific and Technical Information of China (English)

    Yanbo Zhang; Guo Shao; Wei Zhang; Sijie Li; Jingzhong Niu; Dongmei Hu; Mingfeng Yang; Xunming Ji

    2013-01-01

    Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein ki-nase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C ac-tivation.

  8. Housing Abroad: Central and Eastern Europe

    Czech Academy of Sciences Publication Activity Database

    Lux, Martin

    2. Los Angeles : Sage Publications, 2012, s. 320-322. ISBN 9781412989572 R&D Projects: GA ČR GA403/09/1915 Institutional support: RVO:68378025 Keywords : Housing * housing policy * Central and Eeastern Europe Subject RIV: AO - Sociology, Demography

  9. Larger foraminifera from Central Falcon (Venezuela)

    NARCIS (Netherlands)

    Gorter, Nettie E.; Vlerk, van der I.M.

    1931-01-01

    Dr. H. G. Kugler, chief geologist of the North Venezuelan Petroleum Company, at Puerto Cabello, entrusted us with the examination of a collection of larger foraminifera, selected from material collected by the geologists of this Company in Central Falcon. Dr. A. Senn kindly added material that had a

  10. Central modulation of cyclosporine-induced hypertension.

    Science.gov (United States)

    El-Gowelli, Hanan M; El-Mas, Mahmoud M

    2015-03-01

    Arterial hypertension is a considerable side effect that accompanies the clinical use of immunosuppressant drugs such as cyclosporine (CSA). In addition to promoting graft rejection, uncontrolled hypertension is a major risk factor for atherosclerosis, left ventricular hypertrophy, heart failure, and premature death. Most, if not all, reports that reviewed the hypertensive effect of CSA and underlying mechanisms focused on the roles of peripheral vasoactive machinaries, perhaps because of the limited capacity of CSA to diffuse to brain tissues and the lack of any appreciable effect for centrally administered CSA on blood pressure (BP) or central sympathetic outflow. This review focuses primarily on evidence that supports a modulatory role for central neural pathways, as go-between afferent and efferent sympathetic circuits, in the elicitation of the hypertensive action of CSA. Other areas covered briefly in the review include (1) an outline of peripheral mechanisms that contribute to the hypertensive action of CSA, and (2) comparisons of the BP effects of CSA and other calcineurin-dependent (tacrolimus) and independent (sirolimus) immunosuppressants. The knowledge of these mechanisms, central and peripheral, may permit the identification of new therapeutic strategies against CSA hypertension. PMID:25430438

  11. Prehistoric archaeology in Central Europe: beyond diversity

    Czech Academy of Sciences Publication Activity Database

    Sosna, D.; Kolář, Jan; Květina, Petr; Trampota, F.

    2013-01-01

    Roč. 51, č. 2 (2013), s. 123-130. ISSN 0323-1119. [ Theory and method in the prehistoric archaeology of Central Europe. Mikulov, 24.10.2012-26.10.2012] Institutional support: RVO:67985912 ; RVO:67985939 Keywords : archaeological theory * artefact * communication * environment * history of archaeology * reflexivity Subject RIV: AC - Archeology, Anthropology, Ethnology

  12. A central spent fuel storage in Sweden

    International Nuclear Information System (INIS)

    A planned central spent fuel storage facility in Sweden is described. The nuclear power program and quantities of spent fuel generated in Sweden is discussed. A general description of the facility is given with emphasis on the lay-out of the buildings, transport casks and fuel handling. Finally a possible design of a Swedish transportation system is discussed. (author)

  13. Dust on UA1 central detector

    CERN Multimedia

    1982-01-01

    In March 1982 the central derector of UA1 was contaminated by dirt in the compressed air used for cooling during the bakeout of the beam pipe. The lengthy cleaning imposed a change of the collider schedule (Annual Report 1982 p. 114).

  14. Universities and Knowledge Production in Central Europe

    Science.gov (United States)

    Kwiek, Marek

    2012-01-01

    The article discusses an East/West divide in Europe in university knowledge production. It argues that the communist and post-communist legacies in the four major Central European economies studied (Poland, Hungary, the Czech Republic and the Slovak Republic) matter substantially for educational and research systems. The differences in university…

  15. Central Limit Theorem for Coloured Hard Dimers

    Directory of Open Access Journals (Sweden)

    Maria Simonetta Bernabei

    2010-01-01

    Full Text Available We study the central limit theorem for a class of coloured graphs. This means that we investigate the limit behavior of certain random variables whose values are combinatorial parameters associated to these graphs. The techniques used at arriving this result comprise combinatorics, generating functions, and conditional expectations.

  16. Centrality measures for networks with community structure

    Science.gov (United States)

    Gupta, Naveen; Singh, Anurag; Cherifi, Hocine

    2016-06-01

    Understanding the network structure, and finding out the influential nodes is a challenging issue in large networks. Identifying the most influential nodes in a network can be useful in many applications like immunization of nodes in case of epidemic spreading, during intentional attacks on complex networks. A lot of research is being done to devise centrality measures which could efficiently identify the most influential nodes in a network. There are two major approaches to this problem: On one hand, deterministic strategies that exploit knowledge about the overall network topology, while on the other end, random strategies are completely agnostic about the network structure. Centrality measures that can deal with a limited knowledge of the network structure are of prime importance. Indeed, in practice, information about the global structure of the overall network is rarely available or hard to acquire. Even if available, the structure of the network might be too large that it is too much computationally expensive to calculate global centrality measures. To that end, a centrality measure is proposed here that requires information only at the community level. Indeed, most of the real-world networks exhibit a community structure that can be exploited efficiently to discover the influential nodes. We performed a comparative evaluation of prominent global deterministic strategies together with stochastic strategies, an available and the proposed deterministic community-based strategy. Effectiveness of the proposed method is evaluated by performing experiments on synthetic and real-world networks with community structure in the case of immunization of nodes for epidemic control.

  17. Best Minds Sought for Central Office, Startups

    Science.gov (United States)

    Maxwell, Lesli A.

    2009-01-01

    The central office isn't being overlooked in the movement to find and develop top talent for school districts. Although ways to recruit, groom, and keep top teachers and strong principals tend to dominate discussions of "human capital" needs in education, a handful of nonprofit organizations and foundations also see providing smart managers as…

  18. Bank Consolidation: A Central Banker's Perspective

    OpenAIRE

    Mishkin, Frederic S.

    1996-01-01

    This paper looks at why bank consolidation has been taking place in the United States and what the structure of the banking industry might look like in the future. It then discusses the implications of bank consolidation for the economy and the challenge it poses for central bankers.

  19. Stone age transitions. Neolithisation in central Scandinavia

    Directory of Open Access Journals (Sweden)

    Helena Knutsson

    2003-01-01

    Full Text Available A summary of a series of individual research projects focused on the processes from the Mesolithic to the Late Neolithic in central Scandinavia. The projects were embeded in the "Coast to Coast project". The historicity in this process was emphasised.

  20. Observatories in East and Central Europe

    Czech Academy of Sciences Publication Activity Database

    Hejda, Pavel

    Dordrecht: Springer, 2007 - (Gubbins, D.; Herrero-Bervera, E.), s. 728-729. (Encyclopedia of Earth sciences series). ISBN 978-1-4020-3992-8 Institutional research plan: CEZ:AV0Z30120515 Keywords : magnetic observatory * East and Central Europe * INTERMAGNET network Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  1. Quantum Central Processing Unit and Quantum Algorithm

    Institute of Scientific and Technical Information of China (English)

    王安民

    2002-01-01

    Based on a scalable and universal quantum network, quantum central processing unit, proposed in our previous paper [Chin. Phys. Left. 18 (2001)166], the whole quantum network for the known quantum algorithms,including quantum Fourier transformation, Shor's algorithm and Grover's algorithm, is obtained in a unitied way.

  2. Problem of heat pumps in central Russia

    International Nuclear Information System (INIS)

    This article describes the problems of heat pumps due to climatic conditions and the characteristics of energy sources. As energy sources for heat pumps, solar power, air, groundwater, soil, and rejected heat are considered. It is shown that in central Russia it is only rational to use waste heat as an energy source for heat pump systems. (author)

  3. Intracranial calcification in central diabetes insipidus

    International Nuclear Information System (INIS)

    Intracranial calcification is a known but extremely rare complication of diabetes insipidus. To date, only 16 patients have been reported and all had the peripheral (nephrogenic) type of diabetes insipidus. We report a child with intracranial calcification complicating central diabetes insipidus. We also report a child with nephrogenic diabetes insipidus, and compare the patterns of intracranial calcification. (orig.)

  4. Azole-Resistant Central Nervous System Aspergillosis

    NARCIS (Netherlands)

    J.W.M. van der Linden; R.R. Jansen; D. Bresters; C.E. Visser; S.E. Geerlings; E.J. Kuijper; W.J.G. Melchers; P.E. Verweij

    2009-01-01

    Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy

  5. Azole-resistant central nervous system aspergillosis.

    NARCIS (Netherlands)

    Linden, J.W.M. van der; Jansen, R.R.; Bresters, D.; Visser, C.E.; Geerlings, S.E.; Kuijper, E.J.; Melchers, W.J.G.; Verweij, P.E.

    2009-01-01

    Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy

  6. Notes on Central Asian dragonflies (Insecta: Odonata)

    OpenAIRE

    Schoorl Jr., J.W.

    2000-01-01

    New and old material from Central Asia is published. In total 38 species are recorded from various locations in this region. For the more interesting species notes and figures are provided. One probably new Ischnura species is briefly described, but not formally named. For a, possibly new, subspecies of Sympetrum sinaiticum Dumont, 1977, a short diagnosis with figures is provided.

  7. Enhancing the Capability of Central Finance Agencies

    OpenAIRE

    Allen, Richard; Grigoli, Francesco

    2012-01-01

    A well-organized and effective finance ministry and its associated central finance agencies (CFAs) are essential to good fiscal outcomes. Recent studies of CFAs in selected low-income countries demonstrate that their organizational structure varies widely and that decision making on public finance is strongly influenced by political economy factors. This note presents some common themes ar...

  8. Central Virginia Community College 1999 Fact Book.

    Science.gov (United States)

    Hicks, Geoffrey

    The Fact Book is an annual publication of the Office of Research, Assessment and Planning at Central Virginia Community College (CVCC). It includes data and trends from 1994-1998 and is divided into six parts: (1) "The College" includes information on the College Board, institutional history, facilities, mission and goals, revenues and…

  9. The Centrality of Engagement in Higher Education

    Science.gov (United States)

    Fitzgerald, Hiram E.; Bruns, Karen; Sonka, Steven T.; Furco, Andrew; Swanson, Louis

    2016-01-01

    The centrality of engagement is critical to the success of higher education in the future. Engagement is essential to most effectively achieving the overall purpose of the university, which is focused on the knowledge enterprise. Today's engagement is scholarly, is an aspect of learning and discovery, and enhances society and higher education.…

  10. Ichthyofauna of the reservoirs of Central Vietnam

    Directory of Open Access Journals (Sweden)

    I. A. Stolbunov

    2012-01-01

    Full Text Available Species composition, distribution and abundance of fish in the pelagic and littoral zone of four reservoirs of Central Vietnam (Suoi Chau, Kam Lam, Da Ban and Suoi Dau were studied first. According to the research data the fish community of the reservoirs is represented by 43 species of 19 fish families.

  11. On the dimension of twisted centralizer codes

    OpenAIRE

    Glasby, S. P.; Praeger, Cheryl E.; Alahmadi, Adel

    2016-01-01

    Given a field $F$, a scalar $\\lambda\\in F$ and a matrix $A\\in F^{n\\times n}$, the twisted centralizer code $C_F(A,\\lambda):=\\{B\\in F^{n\\times n}\\mid AB-\\lambda BA=0\\}$ is a linear code of length $n^2$. When $A$ is cyclic and $\\lambda\

  12. Hypersensitivity Responses in the Central Nervous System

    DEFF Research Database (Denmark)

    Khorooshi, Reza; Asgari, Nasrin; Mørch, Marlene Thorsen;

    2015-01-01

    of pathology in neuromyelitis optica (NMO), a central nervous system (CNS) demyelinating disease where activated neutrophils infiltrate, unlike in MS. The most widely used model for MS, experimental autoimmune encephalomyelitis, is an autoantigen-immunized disease that can be transferred to naive...

  13. Exercise, Stress Resistance, and Central Serotonergic Systems

    OpenAIRE

    Greenwood, Benjamin N.; Fleshner, Monika

    2011-01-01

    Voluntary exercise reduces the incidence of stress-related psychiatric disorders in humans and prevents serotonin-dependent behavioral consequences of stress in rodents. Evidence reviewed herein is consistent with the hypothesis that exercise increases stress resistance by producing neuroplasticity at multiple sites of the central serotonergic system, which all help to limit the behavioral impact of acute increases in serotonin during stressor exposure.

  14. Central Exclusive Production at the LHC

    CERN Document Server

    Forshaw, J R

    2009-01-01

    After a brief resume of the theory underpinning the central exclusive process (CEP) pp \\to p+H+p, attention is focussed upon Higgs bosons produced in the Standard Model, the MSSM and the NMSSM. In all cases, CEP adds significantly to the physics potential of the LHC and in some scenarios it may be crucial.

  15. Notes on Central Asian dragonflies (Insecta: Odonata)

    NARCIS (Netherlands)

    Schoorl Jr., J.W.

    2000-01-01

    New and old material from Central Asia is published. In total 38 species are recorded from various locations in this region. For the more interesting species notes and figures are provided. One probably new Ischnura species is briefly described, but not formally named. For a, possibly new, subspecie

  16. Medical segetal flora of Central Poland

    OpenAIRE

    Warcholińska, Aurelia Urszula

    2008-01-01

    In the paper a list and general characterization of medical segetal flora of Central Poland is given. This flora consists of 300 taxa. Among the most threatened species there are 6 taxa: Adonis aestivalis, A. flam mea, Anagallis foemina, Bupleurum rotundifolium, Camelina saliva, Cuscuta europaea.

  17. Central control element expands computer capability

    Science.gov (United States)

    Easton, R. A.

    1975-01-01

    Redundant processing and multiprocessing modes can be obtained from one computer by using logic configuration. Configuration serves as central control element which can automatically alternate between high-capacity multiprocessing mode and high-reliability redundant mode using dynamic mode switching in real time.

  18. 论中原经济区的范围、定位及作用%Scope, location and role of Central Plains Economic Region

    Institute of Scientific and Technical Information of China (English)

    陈隆文

    2012-01-01

    中原经济区的范围是以河南为主体,包括河南省南部、山东省西南部、安徽省西北部、陕西省东部等,这个区域正是中国的腹心地带。它的功能定位是以保障农业和粮食生产安全为前提,统筹城乡,努力实现工业化、城镇化和农业现代化协调发展。构建中原经济区不仅直接对国家区域经济发展有利,而且解决了中国社会发展中面临的最根本的困难,所以具有重大战略意义。%The scope of the Central Plains Economic Region takes Henan as the main body, including the southern Henan Province, southwest of Shandong Province, north-west provinces of Anhui Province, the east- ern part of Shaanxi Province, which is the heart of the hinterland. Its functional position is based on the prem- ise of protection of agriculture and food production safety, and the coordinated development for overall urban- rural development, efforts to achieve industrialization, urbanization and agricultural modernization. So build- ing of the Central Plains Economic Region not only directly benefits the development of national and regional e- conomy, but can solve the most fundamental difficulties faced in the development of Chinese society, and therefore has a major strategic significance.

  19. The Mediterranean fruit fly in Central America

    International Nuclear Information System (INIS)

    Various methods of controlling the medfly are available and include the use of insecticides, bait sprays and the sterile insect technique (SIT). Each of these control strategies may be used alone or in sequence. With regard to the application of the SIT, the Joint FAO/IAEA Division of Atomic Energy in Food and Agriculture through its Insect and Pest Control Section and Entomology Laboratory is in an excellent position to assist in containing the medfly in Central America. For the past 12 years, the laboratory has participated in all phases of medfly control by sterile insect releases in various climates. This involvement has included planning of medfly campaigns, development of pre-release techniques (bait spraying, trapping, etc.) and shipment and release of sterilized medflies. Small-scale field tests utilizing the SIT have been carried out by nine countries: Italy (Procida, Capri), Spain, Cyprus, Israel, Tunisia, Peru, Panama, Costa Rica and Nicaragua. Other field projects presently being counselled and serviced are located in Argentina, Venezuela and the Canary Islands. The research and development that are still needed to effectively stabilize and gain control of the medfly situation in Central America include: The development and use of effective quarantine procedures in various countries; Development of effective conventional medfly control procedures under the conditions found in Central America; Development of methods to determine the geographic origin of medflies introduced into new areas; Medfly mass production (viz. all aspects of rearing Central American strains); Assessing the performance (competitiveness, etc.) of various strains; Logistics, including the development of systems for releasing pre-adult stages; Genetic rearing methods: developmental research in this area is particularly promising since the preferential production of males would allow considerable savings in the rearing costs of medflies for release; Development of adequate surveillance

  20. Clinical analysis and treatment of central pain due to headinjury

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@Central pain is induced by the involvement of the abnormal pain pathway due to diseases of the central nervous system. Central pain after brain trauma is common clinically, but it is often misdiagnosed and neglected because of lack of objective disturbances. We treated 20 cases of central pain after head injury by invigorating blood circulation and satisfactory result was obtained.

  1. Kosa (yellow sand) components in precipitation collected at central Japan

    Institute of Scientific and Technical Information of China (English)

    Chohji Tetsuji; Kitamura Moritsugu; Tabata Masahiro

    2002-01-01

    In east Asia, acidic gases derived from fossil fuel combustion have increased in the pastdecades. On the other hand, the Asian dust, also called Kosa (yellow sand) is transported follow-ing windstorms from arid lands in the Asian continent. Many researchers have been interested inthe reaction between acidic aerosols and Kosa aerosols as well as the long-range transport ofthese emissions. To investigate the characteristics of chemical components in precipitation on along-term basis over Japan, precipitation was sequentially collected from April 1984 to March 1997at Kanazawa located near the coast of the Sea of Japan. Precipitation samples were collected at 1mm intervals for the first 5 mm rainfall and all volume of rainwater after 6 mm for all precipitationevents with an automatic wet only precipitation collector. According to the analyses of precipitationincluding Kosa aerosols during Kosa periods, the reaction in the air between Kosa and acidiccomponents during the long-range transport was discussed.

  2. Clinical significance of central corneal thickness and comparison of central corneal thickness

    Directory of Open Access Journals (Sweden)

    Özgür Çakıcı

    2014-03-01

    Full Text Available Significance of central corneal thickness has been increasing in ophthalmology practice. It is an important clinical evaluation tool especially prior to refractive surgery and in diagnosis of glaucoma and keratoconus. Refractive surgery is planned according to preoperative central corneal thickness measurements. Besides, in order to determine actual intraocular pressure, central corneal thickness is measured and corrected eye pressure is obtained. Today, devices used in measurement of central corneal thickness do the measurement according to two principles. First and relatively older method is ultrasonic method. Optic method is the second and more recent method. In daily practice, the most commonly used clinical method in measurement of central corneal thickness is ultrasound pachymeter. However, this measurement technique requires contact between cornea and probe and gives thinner measurement results compared to the methods that use optic principle. Recently, several technologic methods based on optics have been put in use; they provide advantages of non-contact technique and objective determination of central corneal thickness. Of these methods, most commonly used include Specular Microscopy, Optical coherence tomography, Laser Doppler Interferometry, Optical low coherence reflectometry pachymetry, Optic based topographic mapping (also called screening section pachymetry and Pentacam. In this article, it was aimed to evaluate importance of central corneal thickness in clinical use and compare measurement methods. J Clin Exp Invest 2014; 5 (1: 153-158

  3. Solitary Median Maxillary Central Incisor Versus Agenesis of the Maxillary Central Incisor.

    Science.gov (United States)

    de Carvalho, Fabrício Kitazono; Arid, Juliana; De Rossi, Andiara; Paula-Silva, Francisco W G; Nelson-Filho, Paulo

    2016-01-01

    A solitary median maxillary central incisor (SMMCI) is rare and affected individuals may carry a potentially serious condition known as SMMCI syndrome. However, many of these cases do not receive proper attention because they are misdiagnosed as agenesis of the maxillary central incisor. The purpose of this manuscript is to report two cases of children with only one maxillary central incisor and draw diagnostic differences between the entities. A correct diagnosis is very important because if an SMMCI is confirmed, the patient should be referred for genetic counseling. PMID:27098718

  4. Harada Group Uniquely Determined by Centralizer of a 2-Central Involution

    Institute of Scientific and Technical Information of China (English)

    M. Kratzer; G.O. Michler; M. Weller

    2003-01-01

    In this article we show that the sporadic simple Harada group G is uniquely determined up to isomorphism by the centralizer CG(z) of a 2-central involution z of G. This strengthens Y. Segev's uniqueness theorem [24] which required the known structure of the centralizers of two non-conjugate involutions.Using the second author's algorithm [19], we also provide a self-contained existence proof for the Harada group G by giving matrix generators inside GL133(19).Furthermore, the character table of G is determined and representatives for the conjugacy classes of the group are given as short words in the generating matrices.

  5. Modelling Central Bank Independence and Inflation: Deus Ex Machina?

    OpenAIRE

    Dumiter Florin; Brezeanu Petre; Radu Claudia; Turcas Florin

    2015-01-01

    Central bank independence represents the core element of assessing the complex relationship between government and central bank, having at background the fundamental issue of a free monetary policy decision-making process from the hands of the political circle. However, central bank independence is a multilevel concept within some social, economic and behavioral implications both for the central banks and for the society at whole. Central bank independence is needed in order to establish an a...

  6. Does a Good Central Banker make a Difference?

    OpenAIRE

    Matthias Neuenkirch; Peter Tillmann

    2013-01-01

    The personalities of central bankers moved center stage during the recent financial crisis. Some central bankers even gained "superstar" status. In this paper, we evaluate the pivotal role of superstar central bankers by assessing the difference an outstanding governor makes to economic performance. We employ school grades given to central bankers by the financial press. A superstar central banker is one receiving the top grade. In a probit estimation we first relate the grades to measures of...

  7. HANFORD SITE CENTRAL PLATEAU CLEANUP COMPLETION STRATEGY

    Energy Technology Data Exchange (ETDEWEB)

    BERGMAN TB

    2011-01-14

    Cleanup of the Hanford Site is a complex and challenging undertaking. The U.S. Department of Energy (DOE) has developed a comprehensive vision for completing Hanford's cleanup mission including transition to post-cleanup activities. This vision includes 3 principle components of cleanup: the {approx}200 square miles ofland adjacent to the Columbia River, known as the River Corridor; the 75 square miles of land in the center of the Hanford Site, where the majority of the reprocessing and waste management activities have occurred, known as the Central Plateau; and the stored reprocessing wastes in the Central Plateau, the Tank Wastes. Cleanup of the River Corridor is well underway and is progressing towards completion of most cleanup actions by 2015. Tank waste cleanup is progressing on a longer schedule due to the complexity of the mission, with construction of the largest nuclear construction project in the United States, the Waste Treatment Plant, over 50% complete. With the progress on the River Corridor and Tank Waste, it is time to place increased emphasis on moving forward with cleanup of the Central Plateau. Cleanup of the Hanford Site has been proceeding under a framework defmed in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement). In early 2009, the DOE, the State of Washington Department of Ecology, and the U.S. Environmental Protection Agency signed an Agreement in Principle in which the parties recognized the need to develop a more comprehensive strategy for cleanup of the Central Plateau. DOE agreed to develop a Central Plateau Cleanup Completion Strategy as a starting point for discussions. This DOE Strategy was the basis for negotiations between the Parties, discussions with the State of Oregon, the Hanford Advisory Board, and other Stakeholder groups (including open public meetings), and consultation with the Tribal Nations. The change packages to incorporate the Central Plateau Cleanup Completion Strategy were

  8. Volar Central Portal in Wrist Arthroscopy.

    Science.gov (United States)

    Corella, F; Ocampos, M; Cerro, M Del; Larrainzar-Garijo, R; Vázquez, T

    2016-03-01

    Background Nowadays, the wrist is not limited to a dorsal visualization; the joint can be thought of as a "box," which can be visualized from almost every perspective. The purpose of this study was to describe a new volar central portal for the wrist, following three principles: a single incision that allows access to both the radiocarpal and midcarpal joints, centered on the lunate, with the volar structures at risk protected not only by retractors, but also by tendons. Description of Technique The incision begins in the distal wrist crease and extended 1.5 cm proximally up to the proximal wrist crease, following the axis of the third intermetacarpal space. The flexor superficialis tendons are identified and retracted toward the radial side. Next, the fourth and fifth flexor digitorum profundus tendons are retracted toward the ulnar side, while the third and second tendons are retracted toward the radial side. The volar central midcarpal portal is performed under direct vision just over the anterior horn of the lunate through the Poirier space. The volar central radiocarpal portal is created under the lunate through the interval between the ulnocarpal ligaments and the short radioulnar ligament. Methods An anatomical study was performed on 14 cadaver specimens. Two data were recorded: iatrogenic injuries of the structures at risk and the distances to the structures at risk. Results The median (interquartile range [IQR]) distances from the volar central radiocarpal portal to the median nerve, palmar cutaneous branch of the median nerve, and ulnar neurovascular bundle were 10.5 (7.8-15.0), 18.5 (15.8-20.3), and 7.0 (5.0-10.5) mm, respectively. The median (IQR) distances from the volar central midcarpal portal to the median nerve, palmar cutaneous branch of the median nerve, and ulnar neurovascular bundle were 7.0 (4.8-10.3), 16.0 (14.8-19.0), and 4.5 (3.8-9.0) mm, respectively. No iatrogenic injuries were observed. Conclusion The volar central portal is

  9. THE ALLIANCE TRACHYNION DISTACHYAE RIVAS-MARTINEZ 1978 IN CENTRAL ITALYIN CENTRAL ITALY

    Directory of Open Access Journals (Sweden)

    M. DE SANCTIS

    2010-01-01

    Full Text Available The therophytic basiphilous vegetation of Central Italy has been generally framed in a single association Trifolio scabri- Hypochoeridetum achyrophori Biondi et al. 1997. We show that a considerable floristic variation exists inside Trifolio-Hypochoeridetum in Central Italy, and that it should be treated as a complex of no less than five different associations: Medicagini rigidulae-Trifolietum scabri Fanelli et al. hoc loco, Trifolio scabri-Hypochoeridetum achyrophori Biondi, Izco. Ballelli & Formica 1997 s.s, Hippocrepido siliquosae- Brachypodietum distachyi Fanelli et al. ad interim, Trigonello gladiatae-Brachypodietum distachyi Fanelli et al. hoc loc, Crucianello latifoliae-Hypochoeridetum achyrophori Filesi, Blasi, Di Marzio 1996. These associations are floristically and ecologically distinct, and show different geographical ranges in Central Italy. The great diversity of Trachynion distachyae in Central Italy is related to the widespread occurrence of limestone and calcareous alluvial rocks and to a climate with abundant winter and autumn rains very favourable to the development of winter annuals.

  10. Communities, households and animals: convergent developments in Central Anatolian and Central European neolithic:

    OpenAIRE

    Marciniak, Arkadiusz

    2008-01-01

    This paper intends to scrutinize striking similarities in cultural developments and social transformations in Neolithic communities in the North European Plain of Central Europe and Central Anatolia in the early phase of their development and in the following post-Eearly Neolithic period. They will be explored through evidence pertaining to architecture and the organization of space, alongside changes in settlement pattern, as well as animal bone assemblages and zoomorphic representations. So...

  11. Communities, households and animals. Convergent developments in Central Anatolian and Central European Neolithic

    OpenAIRE

    Arkadiusz Marciniak

    2008-01-01

    This paper intends to scrutinize striking similarities in cultural developments and social transformations in Neolithic communities in the North European Plain of Central Europe and Central Anatolia in the early phase of their development and in the following post-Eearly Neolithic period. They will be explored through evidence pertaining to architecture and the organization of space, alongside changes in settlement pattern, as well as animal bone assemblages and zoomorphic representations. So...

  12. Central nervous control of energy and glucose balance: focus on the central melanocortin system

    OpenAIRE

    Xu, Yong; Elmquist, Joel K.; Fukuda, Makoto

    2011-01-01

    Studies have suggested that manipulations of the central melanocortin circuitry by pharmacological agents produce robust effects on the regulation of body weight and glucose homeostasis. In this review, we discuss recent findings from genetic mouse models that have further established the physiological relevance of this circuitry in the context of glucose and energy balance. In addition, we will discuss distinct neuronal populations that respond to central melanocortins to regulate food intak...

  13. Central Asia's raging waters the prospects of water conflict in Central Asia

    OpenAIRE

    Hartman, William B.

    2007-01-01

    This thesis examines the prospects of conflict caused by water scarcity in Central Asia. The thesis analyzes the three most recent political eras of Central Asia, Tsarist Russia, the Soviet Union and independence, utilizing indicators of water tensions including: water quality, water quantity, the management of water for multiple uses, the political divisions and geopolitical setting, state institutions and national water ethos. Although water is not likely to be the sole cause of a majo...

  14. Expansion of museums in Central Europe?

    Directory of Open Access Journals (Sweden)

    Jagodzińska, Katarzyna

    2015-06-01

    Full Text Available The paper presents reflections on the specificity of collections and museums of contemporary art in Central Europe and considers a possibility of creating a regional alternative for the West. The analysis is conducted in the context of the expansionist policy of contemporary museums – notably the Louvre, the Guggenheim Foundation, and the Hermitage – whose numerous new development projects gave rise to a number of dilemmas in the museological world. The author discusses global "museum brands" that invest in Central Europe and addresses the possible profits of the expansion of such "concerns" for culture in the region, as well as emphasises the potential of the region itself, which may be used for its development without the avail of the internationally renowned collectors' names.

  15. Centralizers in simple locally finite groups

    Directory of Open Access Journals (Sweden)

    Mahmut Kuzucuoğlu

    2013-03-01

    Full Text Available This is a survey article on centralizers of finitesubgroups in locally finite, simple groups or LFS-groups as wewill call them. We mention some of the open problems aboutcentralizers of subgroups in LFS-groups and applications of theknown information about the centralizers of subgroups to thestructure of the locally finite group. We also prove thefollowing: Let $G$ be a countably infinite non-linear LFS-groupwith a Kegel sequence $mathcal{K}={(G_i,N_i | iinmathbf{N} }$. If there exists an upper bound for ${ |N_i| |iin mathbf{N} }$, then for any finite semisimplesubgroup $F$ in $G$ the subgroup $C_G(F$ has elements oforder $p_i$ for infinitely many distinct prime $p_i$. Inparticular $C_G(F$ is an infinite group. This answers Hartley'squestion provided that there exists a bound on ${ |N_i| | iin mathbf{N}$.

  16. Hydropower development in the Central Himalayas

    Energy Technology Data Exchange (ETDEWEB)

    Singh, N. (Irrigation Design Organization, Rourkee (India))

    1992-10-01

    The Central Himalayas comprise eight hill districts of the State of Uttar Pradesh, India. These mountains are the source of the Ganga and its main tributaries: the Yamuna, Ramganga and Sarda rivers. The identified hydro potential of the Ganga, Yamuna, Sarda and their tributaries in the Central Himalayas is about 30 000 MW, with an annual average energy potential of 100 TWh. The projects which have been completed so far have only developed 3.2 per cent of this potential. The projects which are now under construction will exploit another 10.4 per cent of the potential. Thus, the untapped potential is as much as 85 per cent of the total. The minor tributaries also offer vast potential for mini and micro hydroelectric stations. In most conservative estimates, this potential is about 2000 MW. (author).

  17. Simulation of macroseismic field in Central Greece

    Directory of Open Access Journals (Sweden)

    J. Drakopoulos

    1996-06-01

    Full Text Available The distribution of seismic intensity is generally influenced by major geological and tectonic features and, on a smaller scale, by local geological conditions, such as the type of surface soil, the surface-to-bedrock soil structure in sedimentary basins and the depth of the saturated zone, The present paper attempted to determine the distribution of macroseismic intensities based on published attenuation laws in the area of Central Greece, using the epicentral intensity, magnitude, length and direction of fault and a considerable number of observation sites, for which the above mentioned information is available, The expected intensity values were then compared to those observed in the same sites, from four earthquakes in Volos, Central Greece, for which the fault plane solutions are also known. The deviations of the observed values from the theoretical model were then related to the local geological conditions and the corresponding correction factor determined for each site.

  18. Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma

    Directory of Open Access Journals (Sweden)

    Prabhu Sudeendra

    2010-01-01

    Full Text Available Glandular odontogenic cyst (GOC is a rare developmental cyst of the jaws. The most common site of occurrence is the anterior mandible, and it is most commonly seen in middle-aged people. It is a destructive lesion with a high rate of recurrence. A predilection for men is observed. Clinical and radiographic findings are not specific, and it can mimic as any other destructive lesion of the jaw. The histopathological features of GOC and those of low-grade central mucoepidermoid carcinoma (MEC are similar. Often, they are misdiagnosed as MEC. We present a case of GOC in the posterior maxilla, which is a rare site. The similarities and differences between GOC and central MEC are also discussed.

  19. Hitherto unreported Agaricus species of Central India

    Directory of Open Access Journals (Sweden)

    MAHENDRA KUMAR RAI

    2010-11-01

    Full Text Available Karwa A, Rai MK. 2010. Hitherto unreported Agaricus species of Central India. Nusantara Bioscience 2: 141-145. Melghat forest region from Central India was surveyed for occurrence of medicinal and culinary mushrooms during the years 2005-2008. Out of total 153 species, ten species of Agaricus were recorded from different localities. Of these, seven species namely Agaricus bitorquis, A. subrufescens, A. augustus, A. placomyces, A. essettei, A. basioanolosus and Agaricus sp. nov (a new species are being reported for the first time from the region. The commercial button mushroom Agaricus bisporus lacks good breeding characters due to its bisporic nature. These wild cousins of the button mushroom can definitely prove to be a good source of genetic manipulations to the existing strains and also to develop new strains with improved characters.

  20. Spherical explosion with a central energy source

    Science.gov (United States)

    Masuyama, Miyu; Shigeyama, Toshikazu; Tsuboki, Yoichiro

    2016-04-01

    We present a novel semi-analytic solution that describes the propagation of a spherical blast wave driven by a central energy source. The initial density profile has a power-law function of the distance from the center and the energy is injected only into the central region at a rate given by a power-law function of time. This solution is composed of three regions separated by the contact surface and the shock front. The innermost region is assumed to be uniform and the outside of the contact surface includes the shocked matter described by self-similar solutions. We analytically derive the applicable range of parameters of this solution from requirements needed to satisfy the boundary conditions. We perform numerical simulations for flows with various values of parameters, some of which reside out of the thus-derived applicable range, and compare the results with the semi-analytic solutions.

  1. A study of Central Exclusive Production

    Energy Technology Data Exchange (ETDEWEB)

    Monk, James; /Manchester U.

    2008-09-01

    Central exclusive production of a system X in a collision between two hadrons h is defined as hh {yields} h + X + h with no other activity apart from the decay products of X. This thesis presents predictions for the production cross section of a CP violating supersymmetric Higgs boson and the radion of the Randall-Sundrum model. The ExHuME Monte Carlo generator was written to simulate central exclusive processes and is described and explored. A comparison to di-jet observations made by the D0 detector at the Tevatron, Fermilab between January and June 2004 is made and the distributions found support the predictions of ExHuME.

  2. Spherical explosion with central energy source

    CERN Document Server

    Masuyama, Miyu; Tsuboki, Yoichiro

    2015-01-01

    We present a novel semi-analytic solution describing the propagation of a spherical blast wave driven by a central energy source. The initial density profile has a power-law function of the distance from the center and the energy is injected only into the central region at a rate given by a power-law function of time. This solution is composed of three regions separated by the contact surface and the shock front. The innermost region is assumed to be uniform and the outside of the contact surface includes the shocked matter described by self-similar solutions. We analytically derive the applicable range of parameters of this solution from requirements to satisfy boundary conditions. We perform numerical simulations for flows with various values of parameters, some of which reside out of the thus derived applicable range, and compare with the semi-analytic solutions.

  3. Centralization vs. decentralization in medical school libraries.

    Science.gov (United States)

    Crawford, H

    1966-07-01

    Does the medical school library in the United States operate more commonly under the university library or the medical school administration? University-connected medical school libraries were asked to indicate (a) the source of their budgets, whether from the central library or the medical school, and (b) the responsibility for their acquisitions and cataloging. Returns received from sixtyeight of the seventy eligible institutions showed decentralization to be much the most common: 71 percent of the libraries are funded by their medical schools; 79 percent are responsible for their own acquisitions and processing. The factor most often associated with centralization of both budget and operation is public ownership. Decentralization is associated with service to one or two rather than three or more professional schools. Location of the medical school in a different city from the university is highly favorable to autonomy. Other factors associated with these trends are discussed. PMID:5945568

  4. Iowa Central Quality Fuel Testing Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Heach, Don; Bidieman, Julaine

    2013-09-30

    The objective of this project is to finalize the creation of an independent quality fuel testing laboratory on the campus of Iowa Central Community College in Fort Dodge, Iowa that shall provide the exploding biofuels industry a timely and cost-effective centrally located laboratory to complete all state and federal fuel and related tests that are required. The recipient shall work with various state regulatory agencies, biofuel companies and state and national industry associations to ensure that training and testing needs of their members and American consumers are met. The recipient shall work with the Iowa Department of Ag and Land Stewardship on the development of an Iowa Biofuel Quality Standard along with the Development of a standard that can be used throughout industry.

  5. Diagnosis and treatment of central diabetes insipidus

    Directory of Open Access Journals (Sweden)

    Ekaterina Aleksandrovna Pigarova

    2014-11-01

    Full Text Available Diabetes insipidus represents a serious disease that dramatically interferes with the everyday life of patients due to the need to constantly replenish of fluid lost in the urine, which comes amid shortage of synthesis, secretion or action of pituitary hormone vasopressin. The main difficulty is the differential diagnosis of types of diabetes insipidus in patients with the syndrome of polydipsia-polyuria as the correct differential diagnosis of these forms predetermine the safety and efficacy of further treatment. This lecture presents the current concepts of etiology, diagnosis and treatment of central diabetes insipidus (CDI. We give the comparative characteristics of various preparations of desmopressin for the treatment of the central form of the disease. We also consider the features of the management of selected patient populations with CDI: during pregnancy and lactation, pathology of the thirst sensation, after traumatic brain injury and neurosurgery.

  6. MINT centralized radiation monitoring system via ethernet

    International Nuclear Information System (INIS)

    Computer networking technologies allow user to receive data and other information easier and faster. This paper describes the development of centralized radiation monitoring system for monitoring of area radiation levels in various locations in MINT complex via Ethernet. The system utilizes a Local Area Network (LAN) known as MINT-NET as a communication media for data acquisition of the area radiation levels from radiation detectors. The development of the system involves system configuration, wiring and hardware installation, interface and software development. Apart from that data distribution package in a web form is also developed. Besides monitoring the area radiation levels in MINT centrally, additional features are developed for effective radiation level trend observation and studies. (Author)

  7. Central auditory neurons have composite receptive fields.

    Science.gov (United States)

    Kozlov, Andrei S; Gentner, Timothy Q

    2016-02-01

    High-level neurons processing complex, behaviorally relevant signals are sensitive to conjunctions of features. Characterizing the receptive fields of such neurons is difficult with standard statistical tools, however, and the principles governing their organization remain poorly understood. Here, we demonstrate multiple distinct receptive-field features in individual high-level auditory neurons in a songbird, European starling, in response to natural vocal signals (songs). We then show that receptive fields with similar characteristics can be reproduced by an unsupervised neural network trained to represent starling songs with a single learning rule that enforces sparseness and divisive normalization. We conclude that central auditory neurons have composite receptive fields that can arise through a combination of sparseness and normalization in neural circuits. Our results, along with descriptions of random, discontinuous receptive fields in the central olfactory neurons in mammals and insects, suggest general principles of neural computation across sensory systems and animal classes. PMID:26787894

  8. Regulation of protein prenyltransferase in central neurons

    OpenAIRE

    Zhou, Xiu-Ping; Luo, Zhen-Ge

    2009-01-01

    Geranylgeranyltransferase I (GGT) is a protein prenyltransferase that mediates lipid modification of some proteins such as Rho family small GTPases. Since the activation of Rho GTPases mediates tumorgenesis and metastasis, GGT has become an attractive target for anti-tumor drug design. Although GGT is extensively expressed in the brain, the function of GGT in central nervous system (CNS) is totally unknown. We have previously shown that GGT was involved in neuromuscular synaptogenesis. In thi...

  9. CDF Central Preshower and Crack Detector Upgrade

    OpenAIRE

    Artikov, A.

    2007-01-01

    The CDF Central Preshower and Crack Detector Upgrade consist of scintillator tiles with embedded wavelength-shifting fibers, clear-fiber optical cables, and multi-anode photomultiplier readout. A description of the detector design, test results from R&D studies, and construction phase are reported. The upgrade was installed late in 2004, and a large amount of proton-antiproton collider data has been collected since then. Detector studies using those data are also discussed.

  10. Ethnobotanical remarks on Central and Southern Italy

    OpenAIRE

    Lucia Leporatti; Guarrera Paolo

    2007-01-01

    Abstract Background The present paper is a brief survey on the ethnobotanical works published by the Authors since 1981, concerning the research carried out in some southern and central Italian regions. Before Roman domination these territories were first inhabited by local people, while the southern areas were colonized by the Greeks. These different cultural contributions left certain traces, both in the toponyms and in the vernacular names of the plants and, more generally, in the culture ...

  11. Nuclear insurance in Central and Eastern Europe

    International Nuclear Information System (INIS)

    In the world outside the former Soviet Union, insurance industries in their respective domestic markets have pooled their resources so as to provide a secure and cost-effective conduit for the transaction of insurance business on behalf of the nuclear industry. These are the so-called nuclear pools. This paper explains the four main principles behind nuclear liability insurance and discusses their application to Central Europe and in particular to the problems facing the nuclear industry in Eastern Europe. (author)

  12. A Central Limit Theorem for Punctuated Equilibrium

    OpenAIRE

    Bartoszek, Krzysztof

    2016-01-01

    Current evolutionary biology models usually assume that a phenotype undergoes gradual change. This is in stark contrast to biological intuition, which indicates that change can also be punctuated - the phenotype can jump. Such a jump can especially occur at speciation, i.e. dramatic change occurs that drives the species apart. Here we derive a central limit theorem for punctuated equilibrium. We show that, if adaptation is fast, for weak convergence to hold, dramatic change has to be a rare e...

  13. RETAIL SUPPLY CHAIN MANAGEMENT THROUGH CENTRALIZED DISTRIBUTION

    OpenAIRE

    Davor Dujak

    2012-01-01

    The paper reviews the trends in the design of distribution systems in retail supply chain management. Through goals, design decisions and costs of distribution system or distribution network, the paper points to the complexity and importance of this area of supply chain management. The goal of paper is to present modern trends in the distribution system, as well as specify the advantages and disadvantages of the leading distribution systems, with a special emphasis on the central distribution...

  14. Hedge funds: a central bank perspective.

    OpenAIRE

    Weber, A.A

    2007-01-01

    The international financial system is undergoing a sustained process of structural change characterised by features such as the rapid growth of the hedge fund industry and credit risk transfer markets. In general, this development should generate positive effects for the efficiency of the financial markets. As the financial system is becoming more complex and less transparent, however, it is becoming a growing challenge for central banks to make an adequate assessment of the potential risks t...

  15. Urban Governance and Participation in Central Mexico

    OpenAIRE

    Valeria Guarneros-Meza

    2007-01-01

    Valeria Guarneros-Meza looks at national aspects that characterize Mexico's democratization and decentralization processes, and their impact upon the central region of Mexico. Based on the region's social characteristics, she discusses the concept of ‘urban governance’ in terms of its ambiguity, which promotes municipal systems of participation at the same time as it fragments their internal organization. Development (2007) 50, 104–109. doi:10.1057/palgrave.development.1100340

  16. Virasoro central charges for Nichols algebras

    CERN Document Server

    Semikhatov, A M

    2011-01-01

    Virasoro central charge associated with Nichols algebras is invariant under the Weyl groupoid action and takes very suggestive values for some items in Heckenberger's list of rank-2 Nichols algebras. In particular, this might be taken as an indication of the existence of reasonable logarithmic extensions of W3==WA2, WB2, and WG2 models of conformal field theory. In the W3 case, the construction of an octuplet extended algebra is outlined.

  17. Probabilistic seismic hazard assessment for Central Asia

    Directory of Open Access Journals (Sweden)

    Shahid Ullah

    2015-04-01

    Full Text Available Central Asia is one of the seismically most active regions in the world. Its complex seismicity due to the collision of the Eurasian and Indian plates has resulted in some of the world’s largest intra-plate events over history. The region is dominated by reverse faulting over strike slip and normal faulting events. The GSHAP project (1999, aiming at a hazard assessment on a global scale, indicated that the region of Central Asia is characterized by peak ground accelerations for 10% probability of exceedance in 50 years as high as 9 m/s2. In this study, carried out within the framework of the EMCA project (Earthquake Model Central Asia, the area source model and different kernel approaches are used for a probabilistic seismic hazard assessment (PSHA for Central Asia. The seismic hazard is assessed considering shallow (depth < 50 km seismicity only and employs an updated (with respect to previous projects earthquake catalog for the region. The seismic hazard is calculated in terms of macroseismic intensity (MSK-64, intended to be used for the seismic risk maps of the region. The hazard maps, shown in terms of 10% probability of exceedance in 50 years, are derived by using the OpenQuake software [Pagani et al. 2014], which is an open source software tool developed by the GEM (Global Earthquake Model foundation. The maximum hazard observed in the region reaches an intensity of around 8 in southern Tien Shan for 475 years mean return period. The maximum hazard estimated for some of the cities in the region, Bishkek, Dushanbe, Tashkent and Almaty, is between 7 and 8 (7-8, 8.0, 7.0 and 8.0 macroseismic Intensity, respectively, for 475 years mean return period, using different approaches. The results of different methods for assessing the level of seismic hazard are compared and their underlying methodologies are discussed.

  18. Central Nevada Test Area Monitoring Report

    International Nuclear Information System (INIS)

    Water level measurements were performed and water samples collected from the Central Nevada Test Area model validation wells in September 2006. Hydraulic head measurements were compared to previous observations; the MV wells showed slight recovery from the drilling and testing operation in 2005. No radioisotopes exceeded limits set in the Corrective Action Decision Document/Corrective Action Plan, and no significant trends were observed when compared to previous analyses

  19. JUNO Central Detector and its prototyping

    Science.gov (United States)

    Wang, Zhimin

    2016-05-01

    JUNO is a multi-purpose underground liquid scintillator experiment; its R&D and civil construction all are in progress. During this July, 2015, JUNO collaboration selects the acrylic option as central detector (CD) scheme. The R&D progress of support point structure and acrylic panel of CD acrylic option all are in good shape. At the same time, a prototype detector of JUNO is designed and under construction, the goal is mainly to study different PMTs, background, electronics etc.

  20. Pandillas and Security in Central America

    OpenAIRE

    Thomas C. Bruneau

    2014-01-01

    This article introduces the topic of pandillas (street gangs) and their implications for security in Central America. There is minimal scholarly literature on pandillas and security. In part this is due to serious challenges in analyzing pandillas. First, pandilla members consider truth to be situational; data derived directly from them is suspect. Second, those who know most about them are involved in NGOs that rely on foreign assistance for their work. The project reports the...