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Sample records for central hidroelectrica ing

  1. Electric generator overhaul of the Ing. Carlos Ramirez Ulloa hydroelectric. Central project conclusions; Rehabilitacion de los generadores de la central hidroelectrica Ing. Carlos Ramirez Ulloa. Conclusiones del proyecto

    Energy Technology Data Exchange (ETDEWEB)

    Campuzano Martinez, Ignacio Roberto; Gonzalez Vazquez, Alejandro Esteban; Robles Pimentel, Edgar Guillermo; Esparza Saucedo, Marcos; Garcia Martinez, Javier; Sanchez Flores, Ernesto; Martinez Romero, Jose Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-12-31

    The Hydroelectric Ing. Carlos Ramirez Ulloa Power Central has three 200 MW electric generators. The Central initiated its commercial operation in 1985. The electric generators had design problems that were properly corrected in an overhaul program that was initiated in 1996, with Unit 2 electric generator and completed in 1998 with Unit 1 electric generator. This paper presents the relevant aspects of the experience accumulated in the project. [Espanol] La central hidroelectrica Ing. Carlos Ramirez Ulloa cuenta con tres generadores de 200 MW cada uno. La central inicio su operacion comercial en 1985. Los generadores tenian problemas de diseno que fueron debidamente corregidos en un programa de rehabilitacion que inicio en 1996, con el generador de la unidad 2, y culmino en 1998 con el generador de la unidad 1. En este articulo se presentan los aspectos relevantes de la experiencia acumulada en el proyecto.

  2. Overhaul of the generator of the hydroelectric central station Ingeniero Carlos Ramirez Ulloa; Rehabilitacion del generador de la unidad 2 de la central hidroelectrica ingeniero Carlos Ramirez Ulloa

    Energy Technology Data Exchange (ETDEWEB)

    Robles Pimentel, Edgar [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Garcia Hernandez, Javier [Comision Federal de Electricidad, Mexico, D. F. (Mexico)

    1997-12-31

    In November 1995, the failure of the Unit 2 generator at the hydroelectric central station Ingeniero Carlos Ramirez Ulloa, El Caracol, occurred. The accident forced to carry out its overhaul. Here are presented the technical problems faced during the overhaul of the generator and analyzed the implemented solutions. [Espanol] En noviembre de 1995 ocurrio la falla del generador de la unidad 2 de la central hidroelectrica Ing. Carlos Ramirez Ulloa, El Caracol. El accidente obligo a llevar a cabo su rehabilitacion. Se presentan los problemas tecnicos enfrentados durante la rehabilitacion del generador y se discuten las soluciones implementadas.

  3. The repair of an electric generator at the Patla hydro central; Reparacion de un generador de la central hidroelectrica de Patla

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez Hernandez, Roman [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    This document describes the repair of the Generator Number 1 of the system of the Unit No. 1 of the Patla Hydro Power Central in Mexico. The tests that were conducted to determine the fault and the location of the same are shown. Mention is made of the fault repair options and the stages in one of the options are described, since it is the one that better covers the expectations for the satisfactory repair of the generator. Finally the commissioning test is described and it is concluded that an increment of 92% (14 MW) in the generation capacity of the unit was achieved, being this the first time a repair of this type is made of generating units [Espanol] Este documento describe la reparacion del generador numero 1 del sistema de la unidad numero 1 de la central hidroelectrica de Patla en Mexico. Se muestran las pruebas que se hicieron para determinar la falla y localizacion de la misma. Se mencionan las alternativas de reparacion de la falla y se describen las etapas de una de las alternativas, ya que es la que cubre mejor las expectativas para la reparacion satisfactoria del generador. Por ultimo se describe la prueba de puesta en servicio y se concluye en que se logro un aumento de la capacidad de generacion de la unidad en un 92% (14 MW), siendo la primera vez que se hace una reparacion de este tipo de unidades generadoras

  4. Methodology for maintenance analysis based on hydroelectric power stations reliability; Metodologia para realizar analisis de mantenimiento basado en confiabilidad en centrales hidroelectricas

    Energy Technology Data Exchange (ETDEWEB)

    Rea Soto, Rogelio; Calixto Rodriguez, Roberto; Sandoval Valenzuela, Salvador; Velasco Flores, Rocio; Garcia Lizarraga, Maria del Carmen [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2012-07-01

    A methodology to carry out Reliability Centered Maintenance (RCM) studies for hydroelectric power plants is presented. The methodology is an implantation/extension of the guidelines proposed by the Engineering Society for Advanced Mobility Land, Sea and Space in the SAE-JA1012 standard. With the purpose of answering the first five questions, that are set out in that standard, the use of standard ISO14224 is strongly recommended. This approach standardizes failure mechanisms and homogenizes RCM studies with the process of collecting failure and maintenance data. The use of risk matrixes to rank the importance of each failure based on a risk criteria is also proposed. [Spanish] Se presenta una metodologia para realizar estudios de mantenimiento Basado en Confiabilidad (RCM) aplicados a la industria hidroelectrica. La metodologia es una implantacion/ extension realizada por los autores de este trabajo, de los lineamientos propuestos por la Engineering Society for Advanced Mobility Land, Sea and Space en el estandar SAE-JA1012. Para contestar las primeras cinco preguntas del estandar se propone tomar como base los modos y mecanismos de fallas de componentes documentados en la guia para recopilar datos de falla en el estandar ISO-14224. Este enfoque permite estandarizar la descripcion de mecanismos de fallas de los equipos, tanto en el estudio RCM como en el proceso de recopilacion de datos de falla y de mantenimiento, lo que permite retroalimentar el ciclo de mejora continua de los procesos RCM. Tambien se propone el uso de matrices de riesgo para jerarquizar la importancia de los mecanismos de falla con base en el nivel de riesgo.

  5. Reliability of hydroelectric generation components, systems and units; Confiabilidad de componentes, sistemas y unidades de generacion hidroelectrica

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Sanchez, Ramon; Torres Toledano, Gerardo; Franco Nava, Jose Manuel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1996-12-31

    This article presents a methodology for the calculation of the reliability of components, systems and hydroelectric generating units, as well as the scope of a computational system for the evaluation of such reliability. In the case of the reliability calculation of components and systems, the computer programs is not limited to hydro stations and can be used in other type of systems. [Espanol] En este articulo se presenta una metodologia para calcular la confiabilidad de componentes, sistemas y unidades de generacion hidroelectrica, asi como el alcance de un sistema computacional para evaluar dicha confiabilidad. En el caso del calculo de confiabilidad de componentes y sistemas, el programa de computo no se limita a centrales hidroelectricas y puede utilizarse en otro tipo de sistemas.

  6. Electro-economic, environmental and social consequences in the efficient abatement of a hydroelectric plant (C. H. Santa Rosa, CFE-ACO); Consecuencias electro-economicas, ambientales y sociales del abatimiento eficiente de una central hidroelectrica (C. H. Santa Rosa, CFE-ACO)

    Energy Technology Data Exchange (ETDEWEB)

    Narvaez Perez, Camilo; Garcia Conejo, Dante Aristoteles [Comision Federal de Electricidad, Centro Nacional de Control de Energia, Area de Control Occidental, Zapopan, Jalisco (Mexico)]. E-mail: camilo.narvaez@cfe.gob.mx; camilo.narvaez@univa.mx; Narvaez Perez, Claudia Universidad de Guadalajara, Zapopan, Jalisco [Mexico]). E-mail: claudia_narvaez@hotmail.com; Blanco Gomez, Cesar Eduardo [Comision Federal de Electricidad, Centro Nacional de Control de Energia, Area de Control Occidental, Zapopan, Jalisco (Mexico)

    2013-03-15

    Renewable energy systems, like hydroelectric generation system gives electric energy, in reliable economic, it takes care with environment, and growths the society, if the hydroelectric dam is suitably drained in non rainy season, if we consider, flow rate in its river, rain, thunderstorms and floods, dam's size, load shape per day, generators capacity unit and the flow in turbines, generating units maintenance and other necessities like irrigation crops in farms. In this research we propose a new methodology about hydroelectric dam drained in non rainy season. But in rainy season, you can consider this methodology with few changes and you would obtain satisfactory results. The methodology is used since 2010 in the Area de Control Occidental in the Comision Federal de Electricidad with results compared with data from previous years, in which different methodologies were applied. [Spanish] Los sistemas de energias renovables, como los complejos hidroelectricos impactan de manera electrica, economica, ambiental y social, siempre y cuando se realice adecuadamente el abatimiento de la presa en el estiaje, considerando, el aporte del cauce, las lluvias aun siendo escasas, el tamano del embalse, la demanda horaria de la carga abastecida, el tamano de los generadores y su gasto turbinado, los mantenimientos de las unidades, las necesidades hidraulicas aguas abajo y demas imponderantes. En esta investigacion se propone una metodologia de abatimiento de presas de centrales hidroelectricas en estiaje. Y para tiempo de lluvias se aplica la metodologia con variantes pequenas y con resultados satisfactorios. La metodologia es utilizada desde el 2010 en el Area de Control Occidental de la Comision Federal de Electricidad, con resultados comparados con los datos de los anos anteriores, en los cuales se aplicaron metodologias diversas.

  7. Hydroelectric microcentrals for small consumption centers; Microcentrales hidroelectricas para pequenos centros de consumo

    Energy Technology Data Exchange (ETDEWEB)

    Angeles A, V. H.; Espino C, F. P. [Universidad Autonoma Metropolitana, Mexico, D. F. (Mexico); Buitron Sanchez, H. C. [Programa de Ahorro de Energia para el Sector Electrico, Mexico, D. F. (Mexico)

    1995-12-31

    The utilization of alternate energy sources (wind power, solar and hydro to small scale) represents an option for the rural electrification. This paper analyzes the case of hydro microgeneration, for this purpose the mechanical and electrical fitting are mainly discussed. For the mechanical re-equipment the turbine types that can be used are fundamentally presented and how they can be selected. As to the electrical re-equipment the different types of electric generators are discussed, as well as the form of selecting them, the operation, the control and the protection in the hydroelectric microcentrals. [Espanol] La utilizacion de fuentes alternas de energia (eolica, solar e hidraulica a pequena escala) representan una alternativa para la electrificacion rural. Este trabajo trata del caso de la microgeneracion hidraulica para la cual se discuten principalmente, alternativas para el equipamiento mecanico y electrico. Para el equipamiento mecanico se presentan fundamentalmente los tipos de turbinas que pueden ser utilizadas y como se pueden seleccionar. En cuanto al equipo electrico se manejan los diferentes tipos de generadores, la forma de seleccionarlos, la operacion, el control y la proteccion en las microcentrales hidroelectricas.

  8. ING proteins in cellular senescence.

    Science.gov (United States)

    Menéndez, Camino; Abad, María; Gómez-Cabello, Daniel; Moreno, Alberto; Palmero, Ignacio

    2009-05-01

    Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.

  9. Ingénierie didactique

    OpenAIRE

    Marty, Olivier

    2015-01-01

    Leçon 1 : introduction théoriqueLeçon 2 : concepts fondamentaux de l’ingénierie didactiqueLeçon 3 : construire une ingénierie pédagogiqueLa didactique professionnelle : autour d’un cas pratiqueLeçon 4 : gestion de l’ingénierie de formation; Master; Cours d'ingénierie didactique. Intervention du premier semestre 2015 dans le master Ingénierie de formation de l'université de Lille.Support progressivement mis à disposition des étudiants dans la plateforme d'enseignement à distance Accel (puis co...

  10. Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis.

    Science.gov (United States)

    Russell, Michael; Berardi, Philip; Gong, Wei; Riabowol, Karl

    2006-04-15

    The INhibitor of Growth (ING) family of plant homeodomain (PHD) proteins induce apoptosis and regulate gene expression through stress-inducible binding of phospholipids with subsequent nuclear and nucleolar localization. Relocalization occurs concomitantly with interaction with a subset of nuclear proteins, including PCNA, p53 and several regulators of acetylation such as the p300/CBP and PCAF histone acetyltransferases (HATs), as well as the histone deacetylases HDAC1 and hSir2. These interactions alter the localized state of chromatin compaction, subsequently affecting the expression of subsets of genes, including those associated with the stress response (Hsp70), apoptosis (Bax, MDM2) and cell cycle regulation (p21WAF1, cyclin B) in a cell- and tissue-specific manner. The expression levels and subcellular localization of ING proteins are altered in a significant number of human cancer types, while the expression of ING isoforms changes during cellular aging, suggesting that ING proteins may play a role in linking cellular transformation and replicative senescence. The variety of functions attributed to ING proteins suggest that this tumor suppressor serves to link the disparate processes of cell cycle regulation, cell suicide and cellular aging through epigenetic regulation of gene expression. This review examines recent findings in the ING field with a focus on the functions of protein-protein interactions involving ING family members and the mechanisms by which these interactions facilitate the various roles that ING proteins play in tumorigenesis, apoptosis and senescence.

  11. RegulatING chromatin regulators

    DEFF Research Database (Denmark)

    Satpathy, Shankha; Nabbi, Arash; Riabowol, Karl

    2013-01-01

    The five human ING genes encode at least 15 splicing isoforms, most of which affect cell growth, differentiation and apoptosis through their ability to alter gene expression by epigenetic mechanisms. Since their discovery in 1996, ING proteins have been classified as type II tumour suppressors on...

  12. Beech bark necrosis: partition- ing the environmental and spatial variation of the damage severity in Central and South-Eastern Europe

    Directory of Open Access Journals (Sweden)

    Benjamín Jarčuška

    2013-12-01

    Full Text Available The beech bark necrosis (BBN infestation severity of European beech (Fagus sylvatica L. was assessed in regions of Central (CE and South-Eastern Europe (SE. Altogether more than 10,000 trees were sampled at 114 sites. Using variation partitioning method, we examined the pure and shared effects of stand, site, climate and spatial sets of variables on mean BBN severity. Our rating included (i the whole stand, (ii tree social status classes, (iii canopy (C and (iv understory (U trees separately. We found that C trees were less affected by BBN than sub-canopy and U trees in both regions. There were found inter-regional differences in amount of explained variability (25.4–73.9% for whole stand BBN and in the sensitivity of C and U trees to the environmental gradients. The analysis revealed that the climate and spatial variables followed by stand variables had the largest marginal effects on mean BBN severity in all models, while the site set of variables had the weakest one. More than half of the explained variation was shared among four sets of variables in SE, contrary to CE. Except to U trees in SE, the effect of climate – pure or spatially structured – remained the highest also after partitioning of variance; more in SE than in CE. Taking into account positive association between mean annual temperature and mean BBN severity in C trees in SE, reinforced negative effect of climate change on the necrosis might be expected to be more serious mainly in low situated beech forests there. Promoting the tree species diversity in forested areas with higher incidence of beech bark necrosis, i.e. in low altitudes in SE, could reduce the susceptibility of forests to the necrosis at regional level in the future. For better understanding of the relative importance of environmental and spatial variables on BBN severity, further research performed on finer spatial scale (extent and grain is necessary, along with accounting for pathogens involved in the

  13. Operator training for the Yacyreta binational hydroelectric power plant; Formacion de operadores para la Central Hidroelectrica de Yacireta

    Energy Technology Data Exchange (ETDEWEB)

    Dure, Francisco; Tachella, Heriberto [Entidad Binacional Yacyreta, Isla Yacireta (Paraguay). Central Hidroelectrica Yacyreta]. E-mail: yacyreta@internet.siscotel.com

    1998-07-01

    This work is oriented to the power plant operators, by exposing the criteria and methods adopted for operators selection, training and incorporation to the Yacyreta Hydroelectric Power Plant. The used criteria considered some aspects, as follows: the operation staff should be consisted of equal numbers of Argentine and Paraguayan nationalities, viewing the both systems operation; experience of the shift supervisors in operating a plant for a minimum of 10 years; the supervisors should participate training the auxiliary operators.

  14. The hydroelectric power plant as a project of private investment; La central hidroelectrica como proyecto de inversion privada

    Energy Technology Data Exchange (ETDEWEB)

    Guerra, Eduardo [Industrias Metalurgicas Pescarmona S.A. (IMPSA), Mendoza (Argentina)]. E-mail: guerra@impsa.com.ar

    2001-07-01

    The paper describes the process to be followed for the performance, construction and operation of a hydroelectric investment from the view point of a private investor. The paper demonstrates that it is possible to finance the project through the 'project finance', where the finance has as guarantee the own assets and the fund fluxes of the investment.

  15. 78 FR 39023 - ING Investments, LLC, et al.;

    Science.gov (United States)

    2013-06-28

    ... COMMISSION ING Investments, LLC, et al.; Notice of Application June 24, 2013. AGENCY: Securities and Exchange..., 2002) (notice) and 25592 (May 24, 2002) (order). Applicants: ING Balanced Portfolio, Inc., ING Equity Trust, ING Funds Trust, ING Intermediate Bond Portfolio, ING Investors Trust, ING Mayflower Trust,...

  16. RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators.

    Science.gov (United States)

    Satpathy, Shankha; Nabbi, Arash; Riabowol, Karl

    2013-03-15

    The five human ING genes encode at least 15 splicing isoforms, most of which affect cell growth, differentiation and apoptosis through their ability to alter gene expression by epigenetic mechanisms. Since their discovery in 1996, ING proteins have been classified as type II tumour suppressors on the basis of reports describing their down-regulation and mislocalization in a variety of cancer types. In addition to their regulation by transcriptional mechanisms, understanding the range of PTMs (post-translational modifications) of INGs is important in understanding how ING functions are fine-tuned in the physiological setting and how they add to the repertoire of activities affected by the INGs. In the present paper we review the different PTMs that have been reported to occur on INGs. We discuss the PTMs that modulate ING function under normal conditions and in response to a variety of stresses. We also describe the ING PTMs that have been identified by several unbiased MS-based PTM enrichment techniques and subsequent proteomic analysis. Among the ING PTMs identified to date, a subset has been characterized for their biological significance and have been shown to affect processes including subcellular localization, interaction with enzymatic complexes and ING protein half-life. The present review aims to highlight the emerging role of PTMs in regulating ING function and to suggest additional pathways and functions where PTMs may effect ING function.

  17. MOdERNIzING AGRICULTURE

    Institute of Scientific and Technical Information of China (English)

    Tang; yuankai

    2013-01-01

    The Central Rural Work Conference charts a new path for development When Zhang Shifang started growing strawberries in her 10 greenhouses in Cuicun Township of Beijing’s Changping District in 2005, she made 40,000 yuan ($6,428).

  18. The ING tumor suppressors in cellular senescence and chromatin.

    Science.gov (United States)

    Ludwig, Susann; Klitzsch, Alexandra; Baniahmad, Aria

    2011-07-18

    The Inhibitor of Growth (ING) proteins represent a type II tumor suppressor family comprising five conserved genes, ING1 to ING5. While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC complexes, the association of ING1, ING4 and ING5 with HAT protein complexes was also reported. Among these the ING1 and ING2 have been analyzed more deeply. Similar to other tumor suppressor factors the ING proteins are also involved in many cellular pathways linked to cancer and cell proliferation such as cell cycle regulation, cellular senescence, DNA repair, apoptosis, inhibition of angiogenesis and modulation of chromatin.A common structural feature of ING factors is the conserved plant homeodomain (PHD), which can bind directly to the histone mark trimethylated lysine of histone H3 (H3K4me3). PHD mutants lose the ability to undergo cellular senescence linking chromatin mark recognition with cellular senescence. ING1 and ING2 are localized in the cell nucleus and associated with chromatin modifying enzymes, linking tumor suppression directly to chromatin regulation. In line with this, the expression of ING1 in tumors is aberrant or identified point mutations are mostly localized in the PHD finger and affect histone binding. Interestingly, ING1 protein levels increase in replicative senescent cells, latter representing an efficient pathway to inhibit cancer proliferation. In association with this, suppression of p33ING1 expression prolongs replicative life span and is also sufficient to bypass oncogene-induced senescence. Recent analyses of ING1- and ING2-deficient mice confirm a tumor suppressive role of ING1 and ING2 and also indicate an essential role of ING2 in meiosis.Here we summarize the activity of ING1 and ING2 as tumor suppressors, chromatin factors and in development.

  19. Project of the new measurement system for energy invoicing - Itaipu Hydroelectric Central; Proyecto del nuevo sistema de medicion de energia para facturacion de la Central Hidroelectrica de Itaipu

    Energy Technology Data Exchange (ETDEWEB)

    Montania E, Julio Cesar [Usina Hidroelectrica de Itaipu Binacional, Assuncion (Paraguay)

    2001-07-01

    Itaipu Binacional has taken a decision of executing a technological updating for the energy measurement system through the substitution of the current system by other one equipped with digital devices. The main reasons for that were the following: a) The equipment in operation were of an outdated generation b) The accuracy class of the existing equipment was of 0.5%, but the tendency for invoicing measurements was to install meters with accuracy class of 0.2% in the enterprises c) The requirements of ONS/MAE, in Brazil, which establishes the minimum requisites to be attended by invoicing measurement systems.

  20. Multiple ING1 and ING2 genes in Xenopus laevis and evidence for differential association of thyroid hormone receptors and ING proteins to their promoters.

    Science.gov (United States)

    Wagner, Mary J; Helbing, Caren C

    2008-03-01

    ING (INhibitor of Growth) tumor suppressor proteins are epigenetic factors involved in numerous cellular processes including apoptosis in species ranging from yeast to humans. We recently isolated ING1 and ING2 transcript variants in Xenopus laevis and showed that these transcripts were differentially regulated by thyroid hormone (TH) during postembryonic development. However, no information exists regarding ING gene structure and how it relates to these differential responses to TH. To further investigate the regulation of ING genes by TH, we isolated ING1 and ING2 gene sequences and demonstrated that there are at least duplicate genes for each. The relationship between transcript variants and their responsiveness to TH were examined through promoter sequence and chromatin immunoprecipitation analyses on tail homogenates. Both TH receptors (TRs) differentially associated with ING1 and ING2 promoter regions with increased recruitment in the presence of TH. This occurred irrespective of gene transcript level response to this hormone. However, differential recruitment of RNA polymerase II corresponded well to transcript levels. ING proteins consistently associated with their own gene promoters except in the region generating the TH-inducible xING1b5 transcript. In this case, a substantial recruitment of TRbeta in the absence ING proteins occurred. These data establish the TH-dependent recruitment of transcription factors to ING promoter regions and suggest that differential TR recruitment in response to TH may not be a sufficient indicator for modulating the expression of ING in the tail.

  1. [Age(ing), ambivalence and mimicry].

    Science.gov (United States)

    Küpper, Thomas

    2016-01-01

    This essay aims to show that the concept of ambivalence could prove especially productive for gerontology. It is known that age(ing) is a category that is characterized by difference and at the same time delineates a process. Ambivalence is eminently suitable for capturing this duality as it enables us to take into account the dynamics peculiar to age(ing) and move beyond those conventional rigid distinctions which fail to grasp key nuances. These theoretical considerations will be put to the test by looking at the so-called young-old and their ambivalent positioning as well as their own mimicry of the middle-agers.

  2. ING4 Loss in Prostate Cancer Progression

    Science.gov (United States)

    2015-10-01

    transcription system (Promega). Synthesized cDNA was amplified for qRT-PCR using SYBR Green Master Mix (Roche) with gene-specific primers and an ABI 7500 RT...siMyc) or a scrambled sequence ( Scr ) on days 2, 4, and 6. D, ING4 andMyc expressionwere detected in undifferentiated (iPr) or in siRNA- treated...Myc or ING4 overexpressing cells were transfected with Bnip3 siRNA (siBnip3) or a scrambled sequence ( Scr ) and immunostained 72 hours later for

  3. "文化-ing"的女人更美丽

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ "-ing"词缀源于英语现在进行时时态,表示正在进行的一种动作或状态. 我们倡导"文化-ing",就如同倡导"美丽-ing"、"快乐-ing"、 "幸福-ing"等美好的文字一样,要使得自己更加富有成就感和魅力.

  4. ING function in apoptosis in diverse model systems.

    Science.gov (United States)

    Shah, Sitar; Smith, Heather; Feng, Xiaolan; Rancourt, Derrick E; Riabowol, Karl

    2009-02-01

    Genetic studies in model organisms have shown that programmed cell death (apoptosis) plays a significant role during development, where a deficiency in apoptosis results in severe and diverse diseases. Dysregulation of apoptosis also contributes to a variety of human diseases, such as cancer and autoimmune diseases. ING family proteins (ING1-ING5) are involved in many cellular processes, and appear to play a significant role in apoptosis. Loss or downregulation of ING protein function is frequently observed in different tumour types, many of which are resistant to apoptosis, thus warranting their classification as type II tumour suppressors. Several different in vitro and in vivo models have explored the role of ING proteins in regulating apoptosis. In this review, we discuss the progress that has been made in understanding ING protein function in apoptosis using in vitro studies and Mus musculus, Xenopus laevis, and Caenorhabditis elegans experimental models, with an emphasis on ING1 and ING3.

  5. The ING family tumor suppressors: from structure to function.

    Science.gov (United States)

    Aguissa-Touré, Almass-Houd; Wong, Ronald P C; Li, Gang

    2011-01-01

    The Inhibitor of Growth (ING) proteins belong to a well-conserved family which presents in diverse organisms with several structural and functional domains for each protein. The ING family members are found in association with many cellular processes. Thus, the ING family proteins are involved in regulation of gene transcription, DNA repair, tumorigenesis, apoptosis, cellular senescence and cell cycle arrest. The ING proteins have multiple domains that are potentially capable of binding to many partners. It is conceivable, therefore, that such proteins could function similarly within protein complexes. In this case, within this family, each function could be attributed to a specific domain. However, the role of ING domains is not definitively clear. In this review, we summarize recent advances in structure-function relationships in ING proteins. For each domain, we describe the known biological functions and the approaches utilized to identify the functions associated with ING proteins.

  6. RESPUESTA DE PECES NATIVOS A FLUCTUACIONES DE CAUDAL PRODUCIDAS POR LA OPERACION DE CENTRALES HIDROELECTRICAS EN EL RIO BIO-BIO

    OpenAIRE

    2011-01-01

    Los sistemas fluviales son ecosistemas de alta diversidad ambiental, cuyos procesos naturales operan mientras se mantengan las condiciones de heterogeneidad espacio–temporal. La biota acuática de estos ecosistemas responde a dicha diversidad presentando patrones de distribución que varían a escala espacial y temporal, asociadas a variables como la disponibilidad de hábitat, la oferta de alimento y el gasto energético asociado a mantenerse en un hábitat. Estas variables pueden ser alteradas...

  7. Interaction between operation and maintenance in the Itaipu Hydroelectric Power Plant, Brazil; Interacciones entre operacion y mantenimiento en la Central Hidroelectrica Itaipu

    Energy Technology Data Exchange (ETDEWEB)

    Vergara Baez, Carlos A. [Itaipu Binacional, Foz do Iguacu, PR (Brazil)]. E-mail: vergara@itaipu.gov.br

    1998-07-01

    This paper demonstrates the importance of the human resources good relationship, cooperation, understanding and training, for obtaining optimized results from the various interactions exiting among the operation and maintenance areas.

  8. ING1 induces apoptosis through direct effects at the mitochondria

    DEFF Research Database (Denmark)

    Bose, P; Thakur, S; Thalappilly, S;

    2013-01-01

    The ING family of tumor suppressors acts as readers and writers of the histone epigenetic code, affecting DNA repair, chromatin remodeling, cellular senescence, cell cycle regulation and apoptosis. The best characterized member of the ING family, ING1,interacts with the proliferating cell nuclear...... translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. The ability of ING1 to induce apoptosis in various breast cancer cell lines correlates well with its degree of translocation...

  9. The ING tumor suppressor genes: status in human tumors.

    Science.gov (United States)

    Guérillon, Claire; Bigot, Nicolas; Pedeux, Rémy

    2014-04-01

    ING genes (ING1-5) were identified has tumor suppressor genes. ING proteins are characterized as Type II TSGs since they are involved in the control of cell proliferation, apoptosis and senescence. They may also function as Type I TSGs since they are also involved in DNA replication and repair. Most studies have reported that they are frequently lost in human tumors and epigenetic mechanisms or misregulation of their transcription may be involved. Recently, studies have described that this loss may be caused by microRNA inhibition. Here, we summarize the current knowledge on ING functions, their involvement in tumor suppression and, in order to give a full assessment of the current knowledge, we review all the studies that have examined ING status in human cancers.

  10. The allocation of hydroelectric units in the short term planning of the operation of electrical power systems; La asignacion de unidades hidroelectricas en la planeacion de corto plazo de la operacion de los sistemas electricos de potencia

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Casillas, Manuel Eduardo

    1986-05-01

    A method is presented to find an approximated solution to the allocation problem of hydroelectric units. The problem consists in determining, for each one of the intervals the planned period, which hydroelectric units will be in operation and how much they will generate, so that the production cost of thermoelectric energy is minimum. The solution must satisfy certain operation policies, and restrictions of physical origin and safety. The modeling of the system elements is very detailed, for example, are considered: the not-linear dependency of the generating units with respect to the cost and the net height, the effects of the discharge level and the losses in conducts, and the relation volume storage against level in the dams. Mathematically, the problem is of non-linear programming, with continuous and discreet variables; in addition, if it is of large scale: in a real case, as de one that appears here, the problem has 16600 continuous variables, 8400 binary variables, and 51000 restrictions. The method exploits the problem structure and the modeled elements characteristics. It obtains a solution in reasonable computing time, and provides a lower elevation to the value of the optimal solution, which allows to judge the quality of the obtained solution. The algorithm was programmed for a VAX 11/780. Problems with a size as the one described are solved in 30 CPU minutes. The value of the obtained solutions, when 35% of the produced energy is hydroelectric, is typically 4% away from its respective inferior elevations. [Spanish] Se presenta un metodo para encontrar una solucion aproximada al problema de asignacion de unidades hidroelectricas. El problema consiste en determinar, para cada uno de los intervalos del periodo de planeacion, cuales unidades hidroelectricas estaran en operacion y cuanto generaran, para que el costo de produccion de energia termoelectrica sea minimo. La solucion debe satisfacer ciertas politicas de operacion y restricciones de origen fisico

  11. Keep-ING balance: tumor suppression by epigenetic regulation.

    Science.gov (United States)

    Tallen, Gesche; Riabowol, Karl

    2014-08-19

    Cancer cells accumulate genetic and epigenetic changes that alter gene expression to drive tumorigenesis. Epigenetic silencing of tumor suppressor, cell cycle, differentiation and DNA repair genes contributes to neoplastic transformation. The ING (inhibitor of growth) proteins (ING1-ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 - and several HAT chromatin-modifying complexes. This review will describe the characteristic pathways by which ING family proteins differentially affect the Hallmarks of Cancer and highlight the various epigenetic mechanisms by which they regulate gene expression. Finally, we will discuss their potentials as biomarkers and therapeutic targets in epigenetic treatment strategies.

  12. Signaling pathways of the ING proteins in apoptosis.

    Science.gov (United States)

    Shah, Sitar; Riabowol, Karl

    2009-05-01

    Members of the ING family of type II tumor suppressors reside in different chromatin regulatory complexes and are stoichiometeric members of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes. It has been frequently observed that expressing ING proteins promotes apoptosis in both normal and transformed cells of different species. They have also been reported to either rely upon p53, or to add to its ability to promote programmed cell death (apoptosis) although whether ING proteins require p53 to induce apoptosis is now questionable based upon observations using knockout cell lines and animal models. Genetic studies in model organisms, and particularly in Caenorhabditis elegans, have identified different pathways involved in apoptosis during development, in the germ line and in response to various forms of stress including DNA damage. In this review we summarize structural features of the INGs and recent observations made in knockout models of Mus musculus and Caenorhabditis elegans that have helped to further clarify the functions of the ING proteins in biochemical pathways leading to apoptosis. Based upon these observations we propose a model for how ING proteins may act both independently and in concert with p53 to promote apoptosis.

  13. The ING observatory in the 2015-2025 decade

    Science.gov (United States)

    Balcells, M.

    2015-05-01

    The Isaac Newton Group, after nearly 30 years of productive operation of the William Herschel, Isaac Newton and Jacobus Kapteyn telescopes, is reviewing its science focus. The central goal is to respond to the changes in the astronomical landscapes in UK, the Netherlands, and especially in Spain, now a mature world-player community with access to 10-m class telescopes on La Palma and Paranal. The current model, which exploits scientific and instrumentation diversity, will continue to be offered until 2017. In the meantime, an ING-led consortium is building WEAVE, a next-generation spectroscopic facility for the WHT. WEAVE is a multi-fibre system capable of deploying either 1000 single-fibre probes, 25 mini-IFUs or a single large IFU, to feed a two-arm bench spectrograph which delivers resolving powers of either 5000 or 20,000. WEAVE will exploit a new field corrector at the WHT that enlarges the prime-focus FOV diameter from the current 40 arcmin to 2 degrees. WEAVE will be used to carry out massive surveys that exploit Gaia data in topics of Milky Way astronomy and stellar evolution; surveys that carry out galaxy evolution studies linked to various multi-wavelength surveys, including the LOFAR radio telescope; and redshift surveys of distant galaxies for cosmology. Community fibres will be available. The expectation is that these surveys will use 70% of the WHT time until at least 2022. The rest of the time will be available via normal TAC allocations, for use of facility instrumentation. Plans for the INT include involving external institutions in the provision of new instrumentation and/or telescope upgrades in exchange for significant fractions of telescope time.

  14. SUMOylation of the ING1b tumor suppressor regulates gene transcription

    DEFF Research Database (Denmark)

    Satpathy, Shankha; Guérillon, Claire; Kim, Tae-Sun;

    2014-01-01

    The INhibitor of Growth (ING) proteins are encoded as multiple isoforms in five ING genes (ING1 -5) and act as type II tumor suppressors. They are growth inhibitory when overexpressed and are frequently mislocalized or downregulated in several forms of cancer. ING1 and ING2 are stoichiometric mem......1b E195A), we further demonstrate that ING1b SUMOylation regulates the binding of ING1b to the ISG15 and DGCR8 promoters, consequently regulating ISG15 and DGCR8 transcription. These results suggest a role for ING1b SUMOylation in the regulation of gene transcription....

  15. Structural insight into histone recognition by the ING PHD fingers.

    Science.gov (United States)

    Champagne, Karen S; Kutateladze, Tatiana G

    2009-05-01

    The Inhibitor of Growth (ING) tumor suppressors are implicated in oncogenesis, control of DNA damage repair, cellular senescence and apoptosis. All members of the ING family contain unique amino-terminal regions and a carboxy-terminal plant homeodomain (PHD) finger. While the amino-terminal domains associate with a number of protein effectors including distinct components of histone deacetylase (HDAC) and histone acetyltransferase (HAT) complexes, the PHD finger binds strongly and specifically to histone H3 trimethylated at lysine 4 (H3K4me3). In this review we describe the molecular mechanism of H3K4me3 recognition by the ING1-5 PHD fingers, analyze the determinants of the histone specificity and compare the biological activities and structures within subsets of PHD fingers. The atomic-resolution structures of the ING PHD fingers in complex with a H3K4me3 peptide reveal that the histone tail is bound in a large and deep binding site encompassing nearly one-third of the protein surface. An extensive network of intermolecular hydrogen bonds, hydrophobic and cation-pi contacts, and complementary surface interactions coordinate the first six residues of the H3K4me3 peptide. The trimethylated Lys4 occupies an elongated groove, formed by the highly conserved aromatic and hydrophobic residues of the PHD finger, whereas the adjacent groove accommodates Arg2. The two grooves are connected by a narrow channel, the small size of which defines the PHD finger's specificity, excluding interactions with other modified histone peptides. Binding of the ING PHD fingers to H3K4me3 plays a critical role in regulating chromatin acetylation. The ING proteins function as tethering molecules that physically link the HDAC and HAT enzymatic complexes to chromatin. In this review we also highlight progress recently made in understanding the molecular basis underlying biological and tumorigenic activities of the ING tumor suppressors.

  16. The fission yeast inhibitor of growth (ING) protein Png1p functions in response to DNA damage.

    Science.gov (United States)

    Chen, Jian-Qiang; Li, Yang; Pan, Xian; Lei, Bing-Kun; Chang, Cheng; Liu, Zheng-Xun; Lu, Hong

    2010-05-21

    In budding yeast and human cells, ING (inhibitor of growth) tumor suppressor proteins play important roles in response to DNA damage by modulating chromatin structure through collaborating with histone acetyltransferase or histone deacetylase complexes. However, the biological functions of ING family proteins in fission yeast are poorly defined. Here, we report that Png1p, a fission yeast ING homolog protein, is required for cell growth under normal and DNA-damaged conditions. Png1p was further confirmed to regulate histone H4 acetylation through collaboration with the MYST family histone acetyltransferase 1 (Mst1). Additionally, both fission yeast PNG1 and MST1 can functionally complement their budding yeast correspondence homologs YNG2 and ESA1, respectively. These results suggest that ING proteins in fission yeast might also conserve function, similar to ING proteins in budding yeast and human cells. We also showed that decreased acetylation in Deltapng1 cells resulted in genome-wide down-regulation of 756 open reading frames, including the central DNA repair gene RAD22. Overexpression of RAD22 partially rescued the png1 mutant phenotype under both normal and DNA-damaged conditions. Furthermore, decreased expression of RAD22 in Deltapng1 cells was confirmed to be caused by decreased H4 acetylation at its promoter. Altogether, these results indicate that Png1p is required for histone H4 acetylation and functions upstream of RAD22 in the DNA damage response pathway.

  17. MUNC-ing around with insulin action.

    Science.gov (United States)

    James, David E

    2005-02-01

    Defective uptake of glucose into muscle and fat cells, or insulin resistance, is a central feature of obesity and type 2 diabetes. As we brace ourselves for the diabetes epidemic, it is reassuring to know that real progress is being made in defining the molecular biology of how insulin stimulates glucose uptake and what goes awry in obesity and type 2 diabetes. An understanding of the molecular determinants of insulin-stimulated glucose transport has been one of the holy grails of hormone action research. A major breakthrough was the discovery that insulin stimulates the translocation of a specific glucose transport protein, GLUT4, from intracellular vesicles to the cell surface. Elucidating how this process is regulated has remained a challenge because it represents a convergence of 2 disparate and complex fields of research--namely, vesicle transport and signal transduction. A study reported in this issue of the JCI using mice lacking Munc18c, one of the vesicle-trafficking proteins involved in GLUT4 translocation, has provided new insights into the signaling/trafficking intersection that controls insulin-stimulated GLUT4 movement.

  18. LACEwING: A New Moving Group Analysis Code

    Science.gov (United States)

    Riedel, Adric R.; Blunt, Sarah C.; Lambrides, Erini L.; Rice, Emily L.; Cruz, Kelle L.; Faherty, Jacqueline K.

    2017-03-01

    We present a new nearby young moving group (NYMG) kinematic membership analysis code, LocAting Constituent mEmbers In Nearby Groups (LACEwING), a new Catalog of Suspected Nearby Young Stars, a new list of bona fide members of moving groups, and a kinematic traceback code. LACEwING is a convergence-style algorithm with carefully vetted membership statistics based on a large numerical simulation of the Solar Neighborhood. Given spatial and kinematic information on stars, LACEwING calculates membership probabilities in 13 NYMGs and three open clusters within 100 pc. In addition to describing the inputs, methods, and products of the code, we provide comparisons of LACEwING to other popular kinematic moving group membership identification codes. As a proof of concept, we use LACEwING to reconsider the membership of 930 stellar systems in the Solar Neighborhood (within 100 pc) that have reported measurable lithium equivalent widths. We quantify the evidence in support of a population of young stars not attached to any NYMGs, which is a possible sign of new as-yet-undiscovered groups or of a field population of young stars.

  19. 77 FR 74245 - ING Investments, LLC, et al.; Notice of Application

    Science.gov (United States)

    2012-12-13

    ... COMMISSION ING Investments, LLC, et al.; Notice of Application December 6, 2012. AGENCY: Securities and...''). Applicants: ING Investments, LLC (``IIL''), Directed Services LLC (``DSL'') and ING Investment Management Co. LLC (``IIM'') (each, an ``Adviser,'' and collectively, the ``Advisers'') and ING Balanced...

  20. Green(ing) English: Voices Howling in the Wilderness?

    Science.gov (United States)

    Bruce, Heather E.

    2011-01-01

    The relatively new fields of ecocriticism in literary studies and ecocomposition in rhetoric and composition studies provide a usable foundation for those interested in green(ing) English. Nevertheless, even suggesting that interest in the environment within English studies is a relatively new concern is somewhat misleading. Contemplation of…

  1. The inhibitor of growth (ING) gene family: potential role in cancer therapy.

    Science.gov (United States)

    Gunduz, Mehmet; Gunduz, Esra; Rivera, Rosario S; Nagatsuka, Hitoshi

    2008-06-01

    The discovery of ING1 gene paved the way to the identification of other ING members (ING2-5) and their isoforms associated with cell cycle, apoptosis and senescence. The ING family has been an emerging putative tumor suppressor gene (TSG) in which the major mechanism is through interaction with the determinants of chromatin function and gene-specific transcription factors. The regulatory mechanism highly involves the conserved plant homeodomain (PHD), which binds to histones in a methylation-sensitive manner, suggesting that ING proteins may contribute to the maintenance of the epigenetic code. Furthermore, ING family members contain nuclear localization signals and N-terminal sequences important in the interaction with histone acetyltransferase (HAT) and histone deacetyltransferase (HDAC) that regulate gene promoter activity within chromatin. Although ING proteins have the same PHD motif, the variation in the N-terminal dictates the differences in tumor the suppressive ability of ING in various tumors. Inactivation of the normal function is achieved through allelic loss of genomic regions containing the ING gene, alteration in the ING promoter region, variation of mRNA splicing efficacy or reduced mRNA stability. It is most probably the apparent combination of these aberrant mechanisms that resulted in reduced availability of functional ING protein. In cancer cells, ING transcript levels are often suppressed but the genes are rarely mutated. The mechanism of suppression of ING expression may have to do with the abnormally high methylation levels of the ING gene promoter, which have been correlated with low transcript levels. Emerging evidence on the function of ING and related regulatory mechanisms strongly points to ING as a candidate TSG and therefore a potential target in the molecular therapy of some types of tumor.

  2. Co-Story-ing: Collaborative Story Writing with Children Who Fear

    Science.gov (United States)

    Pehrsson, Dale-Elizabeth

    2007-01-01

    This article offers a guide for using collaborative story writing (co-story-ing), an assessment technique as well as a therapeutic intervention for children who demonstrate fears, extreme shyness and difficulty in establishing relationships. Co-story-ing draws from Gardner's Mutual Story Telling Technique. Co-story-ing guides clients as they…

  3. The influence of English on Spanish fashion terminology: -ing forms

    OpenAIRE

    Balteiro Fernández, Isabel

    2014-01-01

    As has been the case with other European languages, Spanish has welcomed the arrival of English words, in spite of all purist efforts to the contrary. Moreover, it has not only adopted and adapted true Anglicisms but it has also created other forms based on English patterns, such mechanisms particularly visible in the fashion jargon in Spanish. In this paper we focus on -ing forms in the Spanish language of fashion, which may at times be genuine Anglicisms (formal or semantic ones) or false A...

  4. Application of the bundle of nursing care in cancer patients with indwel ing thoracic central venous catheter%集束化护理在留置胸腔中心静脉导管肿瘤患者中的应用

    Institute of Scientific and Technical Information of China (English)

    钟文娟; 陈娟; 傅芳芳

    2016-01-01

    Objective:To explore the application method and effect of the bundle of nursing care in cancer patients with indwelling tho-racic central venous catheter.Methods:175 cancer patients with indwelling central venous catheter were randomly divided into the control group(n=88)and the intervention group(n=87).The routine nursing care was taken in the control group and the bundle of nursing care was provided in the intervention group,the effect of nursing care was compared between the two groups.Results:The catheter shedding rate was lower in the intervention group than the control group(P<0.05);the satisfaction rate of the patients was higher than the control group (P<0.05).Conclusion:Application of the bundle of nursing care in cancer patients with indwelling thoracic central venous catheter can effectively reduce the incidence of catheter shedding and improve the patient′s satisfaction.%目的:探讨集束化护理在留置胸腔中心静脉导管肿瘤患者中的应用方法及效果。方法:将175例留置胸腔中心静脉导管肿瘤患者随机分为对照组88例和干预组87例,对照组实施常规护理,干预组实施集束化护理,比较两组护理效果。结果:干预组脱管发生率低于对照组(P<0.05),满意度高于对照组(P<0.05)。结论:集束化护理可有效降低留置胸腔中心静脉导管肿瘤患者的脱管发生率,提高其满意度。

  5. Radioprotection et ingénierie nucléaire

    CERN Document Server

    2006-01-01

    Le développement de l'énergie nucléaire repose sur deux piliers essentiels : la sûreté nucléaire, qui concerne la machine, et la radioprotection, qui se préoccupe des hommes. Construit de manière fiable, un réacteur nucléaire se doit d'irradier le moins possible ses opérateurs et conduire à un impact très faible pour les populations avoisinantes. Tout cela est soumis à des règles strictes, élaborées au niveau international, et qui ne tolèrent aucun écart. Les ingénieurs qui ont à concevoir, construire et conduire ces machines doivent maîtriser les règles de protection : cet ouvrage leur est destiné. La radioprotection, si elle se fonde principalement sur des bases scientifiques, intègre également une dimension sociétale exigeante. Ces activités sont en effet sous le regard critique et permanent de nos concitoyens, qui exigent des acteurs de cette industrie une maîtrise totale de la radioprotection ; un ingénieur qui ne connaîtrait pas la genèse de la radioprotection, ses règle...

  6. ING3基因与肿瘤关系的研究进展%The role of ING3 gene in human tumor research

    Institute of Scientific and Technical Information of China (English)

    潘文婧

    2011-01-01

    The inhibitors of growth (ING) family( INGI-5), which are considered as type 2 tumor suppressors, are involved in the regulation of various processes ranging from cell growth, proliferation, cell cycle and cellular senescence to apoptosis.The ING3 gene, a novel number of the lNG family, mapped to 7q31.3, is widely expressed in normal human tissues.However, loss or down regulation of ING3 expression is observed in most cancers, such as human colorectal cancer, head and neck cancer or skin malignant melanoma.The phenomenon demonstrates that the loss of ING3 activity by multiple mechanisms may facilitate tumorigenesis.In this review, we have summarized the progress that has been made in understanding the role of ING3 protein in different types of tumors.%ING基因家族(ING1-5)被认为是2型肿瘤抑制基因,参与细胞生长、增殖、细胞周期调控和细胞衰老等不同的生物学过程.新近发现的ING3基因,定位于染色体7q31.3,广泛表达于正常人体组织.但在多种类型肿瘤中ING3的表达下调或缺失,例如大肠癌、头颈癌以及皮肤恶性黑色素瘤等.该现象表明,多种机制导致的ING3失活可能促进了肿瘤的发生.本文对ING3基因与不同类型肿瘤关系的研究进展作一综述.

  7. Matematisk forståing: Kva legg eleven i omgrepet matematisk forståing, og korleis jobbar eleven for å tileigna seg forståing i matematikk?

    OpenAIRE

    2015-01-01

    Formålet bak forskings og utviklingsarbeidet mitt var å danna eit bilete av kva faktorar som bidreg til læring i matematikkfaget hos elevane. Eg valde dette fokusområdet for undersøkinga slik at eg som framtidig matematikklærar kan vera rusta til å rettleia elevane mot å utvikle forståing i matematikk. Difor lydar problemstillinga som følgjar: «Kva legg eleven i omgrepet matematisk forståing, og korleis jobbar eleven for å tileigna seg forståing i matematikk?» I teorikapittelet presenterer eg...

  8. Parading memory and re-member-ing conflict

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris

    Parading memory and re-member-ing conflict: Collective memory in transition in Northern Ireland This paper leverages an understanding of collective memory to examine the politico-cultural practice of parading in Northern Ireland and so extends our knowledge of the role of memory and commemoration...... understandings of the role of history and memory as conflict dynamics, as well as strategies for studying these as both critical events and as critical continuities. In Northern Ireland, parades provide a unique case for this approach as they draw on and reframe collective memories through partly ritualised...... these ways, they are vernaculars that can unsettle received or official narratives attempting to smooth over differences and anxieties in transitory times. The emotive use of collective memory to charge processes of identity formation often form part of protracted and sectarian conflict (Horowitz [1985] 2000...

  9. Forum-ing: Signature practice for public theological discourse

    Directory of Open Access Journals (Sweden)

    Edward P. Wimberly

    2014-02-01

    Full Text Available This article introduces a unique model for public theological conversation and discourse, which was developed by the Concerned Black Clergy of Atlanta (CBC. It was a model developed in response to the problems of poverty, homelessness, and the ‘missing and murdered children’ victimised in Atlanta, Georgia in the United States of America in the early 1980s. It was originally organised to respond to the economic, financial, spiritual, emotional, employment, housing and resource needs of the underserved poor. This unique practice is called forum-ing. The forum meets every Monday morning, except when there is a national holiday. It has operated 30 consecutive years. The forum has a series of presentations, including the opening prayer, self-introductions of each person, a report of the executive director, special presentations from selected community groups, reports, and then questions and answers. The end result is that those attending engage in a process of discourse that enables them to internalise new ideas, approaches, and activities for addressing poverty and injustice in the community. Key to forum-ing for the 21st century is that it is a form of public practical theology rooted and grounded in non-violence growing out of the civil rights movement of the 1950s and 1960s in the United States. The overall purpose of this article is to contribute to the effort of the Faculty of Theology at the University of Pretoria (South Africa to identify those variables that will assist religious leaders in South Africa to develop public conversational spaces to enhance democratic participation. This article presents one model from the African American community in Atlanta, Georgia. The hope is to lift up key variables that might assist in the practical and pastoral theological conversation taking place in South Africa at present.

  10. Advancement of Study between ING4 Gene and Tumor%ING4基因与肿瘤的研究进展

    Institute of Scientific and Technical Information of China (English)

    兰会华(综述); 黄华艺(审校)

    2015-01-01

    Inhibitor of growth(ING) family is considered to be a candidate tumor suppressor gene,and ING4 gene is a new member of the family .ING4 was significantly downregulated in several tumors:gastric cancer,colorectal cancer, hepatocellular carcinoma, pancreatic cancer, lung cancer, breast cancer, ovarian cancer,prostate cancer,bladder cancer,glioma,and melanoma.ING4 is not only involved in the development and prognosis of tumors,but also enhances the sensitivity of tumor cells to chemotherapeutic drugs .%生长抑制因子( ING)家族是候选的抑癌基因,ING4基因是该家族的新成员。 ING4基因在正常组织中表达丰富,在胃癌、结直肠癌、肝细胞癌、胰腺癌、肺癌、乳腺癌、卵巢癌、前列腺癌、膀胱癌、神经胶质瘤、黑色素瘤等多种恶性肿瘤组织中表达明显下调。 ING4基因不仅参与了肿瘤的发生、发展及预后,还能增强肿瘤细胞对化疗药物的敏感性。

  11. Ground failure in direct current systems of the Itaipu Hydroelectric Power Plant, Parana, Brazil. Impact in the operation; Falla a tierra en sistemas de corriente continua en la Central Hidroelectrica Itaipu, PR, Brasil. Impacto en la operacion

    Energy Technology Data Exchange (ETDEWEB)

    Soto Santacruz, Heriberto [Itaipu Binacional, Foz do Iguacu, PR (Brazil)]. E-mail: soto@itaipu.gov.py

    1998-07-01

    The objective of this work is to share with other companies the operation experience obtained by researching the direct current systems ground failure, in the Itaipu Hydroelectric Power Plant. During the research process electrical and/or electronic components can be damaged, and also human failures can occurred during the circuit connection and disconnection manoeuvres, necessary for the identification of the components causing the failures.

  12. Technological upgrade of static system excitation of a hydraulic generator of 700 Mwats of the Hydroelectric Power Station Guri; Actualizacion tecnologica del sistema de excitacion estatico de un generador hidraulico de 700 MVA de la Central Hidroelectrica de Guri

    Energy Technology Data Exchange (ETDEWEB)

    Contreras, Romy; Guevara, Olivia [C.V.G. Electrificacion del Caroni, C.A. (EDELCA) (Venezuela)

    2004-07-01

    The Generating Units of 700 Mwatts of the Guri Plant from EDELCA are equipped with static excitation systems of analogue technology that using the closure and field's opening switch as a mechanism for the respective processes of excitation and generator dropout. This operational pattern, although functional, has been discontinuing by existing producers because of the inconvenience involved in the management of energy stored in field generator during the dropout. Alternatively, the manufacturers employ a technique of dropout without opening the switch field, based on return to the excitation transformer the energy contained in the field generator. This paper summarizes the EDELCA initiative to upgrade technologically their Generating Units, converting the excitement and dropout switch without opening the field. The project started with a phase of preliminary tests that showed the feasibility of the change and ended with the final implementation of the new scheme in a first unit (Generator n. 15). The results were successful, covering the expectations of the company, so it was decided to continue the project, extending it to the rest of the Generating Units. (author)

  13. Allelic loss of the ING gene family loci is a frequent event in ameloblastoma.

    Science.gov (United States)

    Borkosky, Silvia S; Gunduz, Mehmet; Beder, Levent; Tsujigiwa, Hidetsugu; Tamamura, Ryo; Gunduz, Esra; Katase, Naoki; Rodriguez, Andrea P; Sasaki, Akira; Nagai, Noriyuki; Nagatsuka, Hitoshi

    2010-01-01

    Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors that physically and functionally interact with p53 to perform important roles in apoptosis, DNA repair, cell cycle regulation, and senescence. TP53 genetic alterations were reported to infrequently occur in ameloblastoma. Considering that other TSGs related to TP53 could be altered in this tumor, we focused our study on the ING family genes. We analyzed the loss of heterozygosity (LOH) status of the ING family (ING1-ING5) chromosomal loci in a group of ameloblastomas by microsatellite analysis, and correlated the ING LOH status with clinicopathological characteristics. By using specific microsatellite markers, high frequency of LOH was found at the loci of each ING gene family member (33.3-72.2%). A significant relationship was shown between LOH of D2S 140 (ING5 locus) and solid tumor type (p = 0.02). LOH of ING3MS (ING3 locus) was also high in solid type tumors, showing a near significant association. In addition, a notable tendency toward higher LOH for half of the markers was observed in recurrent cases. LOH of ING family genes appears as a common genetic alteration in solid ameloblastoma. The current study provides interesting novel information regarding the potential prognostic significance of the allelic loss of the ING gene family loci in ameloblastoma tumorigenesis.

  14. Modulators of inhibitor of growth (ING) family expression in development and disease.

    Science.gov (United States)

    Maher, Stacey K; Helbing, Caren C

    2009-05-01

    The inhibitor of growth (ING) gene family proteins regulate many critical cellular processes such as cell proliferation and growth, apoptosis, DNA repair, senescence, angiogenesis, and drug resistance. Their transcripts and proteins are differentially expressed in health and disease and there is evidence for developmental regulation. The vast majority of studies have characterized ING levels in the context of cancer. However, relatively little attention has been paid to the expression of ING family members in other contexts. This review summarizes the findings from human and animal model systems that provide insight into the factors influencing the expression of these important proteins. We examine the influence of cell cycle and aging as well as genotoxic stress on ING expression levels and evaluate several emerging areas of inquiry demonstrating that ING gene activity may be modulated by factors such as the p53 tumor suppressor, DNA methylation, and ING proteins themselves with external factors such as hormones, reactive oxygen species, TGFbeta signalling, and other proteins of pathological significance also influencing ING levels. We then briefly discuss the influence of post-translational modification and changes in subcellular localization as it pertains to modulation of ING expression. Understanding how ING expression is modulated represents a vital aspect of effective drug targeting strategies.

  15. Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancer.

    Directory of Open Access Journals (Sweden)

    Sara A Byron

    Full Text Available Nuclear Factor kappa B (NF-κB is a key mediator of normal immune response but contributes to aggressive cancer cell phenotypes when aberrantly activated. Here we present evidence that the Inhibitor of Growth 4 (ING4 tumor suppressor negatively regulates NF-κB in breast cancer. We surveyed primary breast tumor samples for ING4 protein expression using tissue microarrays and a newly generated antibody. We found that 34% of tumors expressed undetectable to low levels of the ING4 protein (n = 227. Tumors with low ING4 expression were frequently large in size, high grade, and lymph node positive, suggesting that down-regulation of ING4 may contribute to breast cancer progression. In the same tumor set, we found that low ING4 expression correlated with high levels of nuclear phosphorylated p65/RelA (p-p65, an activated form of NF-κB (p = 0.018. Fifty seven percent of ING4-low/p-p65-high tumors were lymph node-positive, indicating a high metastatic tendency of these tumors. Conversely, ectopic expression of ING4 inhibited p65/RelA phosphorylation in T47D and MCF7 breast cancer cells. In addition, ING4 suppressed PMA-induced cell invasion and NF-κB-target gene expression in T47D cells, indicating that ING4 inhibited NF-κB activity in breast cancer cells. Supportive of the ING4 function in the regulation of NF-κB-target gene expression, we found that ING4 expression levels inversely correlated with the expression of NF-κB-target genes in primary breast tumors by analyzing public gene expression datasets. Moreover, low ING4 expression or high expression of the gene signature composed of a subset of ING4-repressed NF-κB-target genes was associated with reduced disease-free survival in breast cancer patients. Taken together, we conclude that ING4 negatively regulates NF-κB in breast cancer. Consequently, down-regulation of ING4 leads to activation of NF-κB, contributing to tumor progression and reduced disease-free patient survival in

  16. 78 FR 18634 - ING Life Insurance and Annuity Company, et al; Notice of Application

    Science.gov (United States)

    2013-03-27

    ... investment adviser and an indirect wholly owned subsidiary of ING Groep, N.V.\\1\\ The Replacement Fund is sub... announced that ING and its U.S. insurance affiliates, including the Companies, are preparing for a base case... affiliates, including DSL. 6. The Contracts are individual variable annuity contracts. Each of the...

  17. Potential usage of ING family members in cancer diagnostics and molecular therapy.

    Science.gov (United States)

    Gunduz, Mehmet; Demircan, Kadir; Gunduz, Esra; Katase, Naoki; Tamamura, Ryo; Nagatsuka, Hitoshi

    2009-05-01

    The Inhibitor of Growth (ING) gene family is an emerging putative type II tumor suppressor gene (TSG). Proteins of INGs (ING1-5), critical modulator of the histone code via PHD fingers, are able to suppress cell growth and proliferation, induce apoptosis, and modulate cell cycle progression. ING proteins are involved in transcriptional regulation of genes, such as the p53-inducible gene p21. ING proteins also serve as shuttling proteins between nucleus and cytoplasm, and dysregulation of this nucleocytoplasmic traffic has been shown in some cancer cells. In cancer cells, ING mRNA levels are often lost or suppressed but the genes are rarely mutated. Recently the potential roles of ING proteins as prognostic biomarkers, detection of aggressive behavior of the tumor as well as prediction of chemo-radiotherapy response have also emerged. In this review, we summarize the up-to-date knowledge on functions of the ING proteins, the protein status in human tumors and discuss as a potential target in the molecular diagnostics and therapy of cancer.

  18. Regulation of p53 by ING family members in suppression of tumor initiation and progression.

    Science.gov (United States)

    Jafarnejad, Seyed Mehdi; Li, Gang

    2012-06-01

    The INhibitor of Growth (ING) family is an evolutionarily conserved set of proteins, implicated in suppression of initiation and progression of cancers in various tissues. They promote cell cycle arrest, cellular senescence and apoptosis, participate in stress responses, regulate DNA replication and DNA damage responses, and inhibit cancer cell migration, invasion, and angiogenesis of the tumors. At the molecular level, ING proteins are believed to participate in chromatin remodeling and transcriptional regulation of their target genes. However, the best known function of ING proteins is their cooperation with p53 tumor suppressor protein in tumor suppression. All major isoforms of ING family members can promote the transactivition of p53 and the majority of them are shown to directly interact with p53. In addition, ING proteins are thought to interact with and modulate the function of auxiliary members of p53 pathway, such as MDM2, ARF , p300, and p21, indicating their widespread involvement in the regulation and function of this prominent tumor suppressor pathway. It seems that p53 pathway is the main mechanism by which ING proteins exert their functions. Nevertheless, regulation of other pathways which are not relevant to p53, yet important for tumorigenesis such as TGF-β and NF-κB, by ING proteins is also observed. This review summarizes the current understanding of the mutual interactions and cooperation between different members of ING family with p53 pathway and implications of this cooperation in the suppression of cancer initiation and progression.

  19. 76 FR 45303 - ING Asia Pacific High Dividend Equity Income Fund, et al.; Notice of Application

    Science.gov (United States)

    2011-07-28

    ... Advantage and Premium Opportunity Fund (``IGA''); ING Global Equity Dividend and Premium Opportunity Fund..., each applicant was able to rely on the exemptive order granted in the Matter of ING Clarion Real Estate... (since as a practical matter excess gains must be distributed and accordingly would not be available...

  20. The ING gene family in the regulation of cell growth and tumorigenesis.

    Science.gov (United States)

    Coles, Andrew H; Jones, Stephen N

    2009-01-01

    The five members of the inhibitor of growth (ING) gene family have garnered significant interest due to their putative roles as tumor suppressors. However, the precise role(s) of these ING proteins in regulating cell growth and tumorigenesis remains uncertain. Biochemical and molecular biological analysis has revealed that all ING members encode a PHD finger motif proposed to bind methylated histones and phosphoinosital, and all ING proteins have been found as components of large chromatin remodeling complexes that also include histone acetyl transferase (HAT) and histone deacetylase (HDAC) enzymes, suggesting a role for ING proteins in regulating gene transcription. Additionally, the results of forced overexpression studies performed in tissue culture have indicated that several of the ING proteins can interact with the p53 tumor suppressor protein and/or the nuclear factor-kappa B (NF-kappaB) protein complex. As these ING-associated proteins play well-established roles in numerous cell processes, including DNA repair, cell growth and survival, inflammation, and tumor suppression, several models have been proposed that ING proteins act as key regulators of cell growth not only through their ability to modify gene transcription but also through their ability to alter p53 and NF-kappaB activity. However, these models have yet to be substantiated by in vivo experimentation. This review summarizes what is currently known about the biological functions of the five ING genes based upon in vitro experiments and recent mouse modeling efforts, and will highlight the potential impact of INGs on the development of cancer.

  1. ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.

    Science.gov (United States)

    Li, Xiaohan; Kikuchi, Keiji; Takano, Yasuo

    2011-01-01

    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world. The evolution and progression of HNSCC are considered to result from multiple stepwise alterations of cellular and molecular pathways in squamous epithelium. Recently, inhibitor of growth gene (ING) family consisting of five genes, ING1 to ING5, was identified as a new tumor suppressor gene family that was implicated in the downregulation of cell cycle and chromatin remodeling. In contrast, it has been shown that ING1 and ING2 play an oncogenic role in some cancers, this situation being similar to TGF-β. In HNSCC, the ING family has been reported to be downregulated, and ING translocation from the nucleus to the cytoplasm may be a critical event for carcinogenesis. In this paper, we describe our recent results and briefly summarize current knowledge regarding the biologic functions of ING in HNSCC.

  2. 76 FR 54770 - Public Meeting: Notification by Capital One Financial Corporation, McLean, VA, To Acquire ING...

    Science.gov (United States)

    2011-09-02

    ... Public Meeting: Notification by Capital One Financial Corporation, McLean, VA, To Acquire ING Bank, FSB, Wilmington, DE, and Indirectly To Acquire Shares of Sharebuilder Advisors, LLC and ING Direct Investing, Inc... Financial Corporation, McLean, Virginia, to acquire ING Bank, FSB, Wilmington, Delaware, and indirectly...

  3. Inges Kindlustus kukkus kahjumisse. Kindlustushindade alandamata jätmine viis miinusesse / Kadrin Karner

    Index Scriptorium Estoniae

    Karner, Kadrin

    2011-01-01

    Inges Kindlustuse kahjumi põhjustas kõrgema hinnataseme säilitamine ning juhatuse liikmele välja makstud märkimisväärne tasu. Konkurentide RSA Kindlustus, Ergo Kindlustuse AS ja IF Kindlustus majandustulemused

  4. Preface of Comments on Shij ing and Paean to Shij ing%《诗说》序与《诗赞》

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    The article is an excerpt from Comments on Shij ing (a classic book of poetry ), a posthumous manuscript by professor Pan Yuting,in which he interpreted the Shij ing in the light of I ching (Book of Changes ).The unfinished manuscript is clearly organized into four volumes.Volumes 1,2, and 3 interpret Airs , H ymns and Eulogies respectively, and volume 4 illuminates the underlying structure of Shij ing .This article includes preface and paean of the manuscript,and is published first time for those interested in exploring the connection between Shij ing and I Ching .%文章是潘雨廷先生(19251991)遗稿《诗说》的选刊。《诗说》是一部从《易经》的角度解说《诗经》的著作,没有最后完成,然而大体已见。全稿分四卷,前三卷分别解说《风》《雅》《颂》,第四卷阐明《诗经》的纲领。此处先行刊载其中的《序》和《赞》,供经学研究者参考。

  5. Parading Memory and Re-member-ing Conflict

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris

    2015-01-01

    and spatial terms, this article examines the role of parades in the current ‘post-conflict’ phase of the peace process as it plays out in a particular location, namely North Belfast. Using theories of cultural and collective memory and examples from republican and loyalist parades in North Belfast...... should be understood both horizontally: as majority memory traditions move to minority memory positions, and vertically: in relation to the increasing dissonance between vernacular practices of conflict and the official post-conflict discourses in Northern Ireland. Central to these arguments...

  6. Parading memory and re-member-ing conflict

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris

    2015-01-01

    and spatial terms, this article examines the role of parades in the current ‘post-conflict’ phase of the peace process as it plays out in a particular location, namely North Belfast. Using theories of cultural and collective memory and examples from republican and loyalist parades in North Belfast...... should be understood both horizontally: as majority memory traditions move to minority memory positions; and vertically: in relation to the increasing dissonance between vernacular practices of conflict and the official post-conflict discourses in Northern Ireland. Central to these arguments...

  7. ING1 and 5-azacytidine act synergistically to block breast cancer cell growth.

    Directory of Open Access Journals (Sweden)

    Satbir Thakur

    Full Text Available BACKGROUND: Inhibitor of Growth (ING proteins are epigenetic "readers" that recognize trimethylated lysine 4 of histone H3 (H3K4Me3 and target histone acetyl transferase (HAT and histone deacetylase (HDAC complexes to chromatin. METHODS AND PRINCIPAL FINDINGS: Here we asked whether dysregulating two epigenetic pathways with chemical inhibitors showed synergistic effects on breast cancer cell line killing. We also tested whether ING1 could synergize better with chemotherapeutics that target the same epigenetic mechanism such as the HDAC inhibitor LBH589 (Panobinostat or a different epigenetic mechanism such as 5-azacytidine (5azaC, which inhibits DNA methyl transferases. Simultaneous treatment of breast cancer cell lines with LBH589 and 5azaC did not show significant synergy in killing cells. However, combination treatment of ING1 with either LBH589 or 5azaC did show synergy. The combination of ING1b with 5azaC, which targets two distinct epigenetic mechanisms, was more effective at lower doses and enhanced apoptosis as determined by Annexin V staining and cleavage of caspase 3 and poly-ADP-ribose polymerase (PARP. ING1b plus 5azaC also acted synergistically to increase γH2AX staining indicating significant levels of DNA damage were induced. Adenoviral delivery of ING1b with 5azaC also inhibited cancer cell growth in a murine xenograft model and led to tumor regression when viral concentration was optimized in vivo. CONCLUSIONS: These data show that targeting distinct epigenetic pathways can be more effective in blocking cancer cell line growth than targeting the same pathway with multiple agents, and that using viral delivery of epigenetic regulators can be more effective in synergizing with a chemical agent than using two chemotherapeutic agents. This study also indicates that the ING1 epigenetic regulator may have additional activities in the cell when expressed at high levels.

  8. ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.

    Science.gov (United States)

    Zhang, Feng; Zhang, Xutao; Meng, Jin; Zhao, Yong; Liu, Xinli; Liu, Yanxia; Wang, Yukun; Li, Yuhua; Sun, Yang; Wang, Zhipeng; Mei, Qibing; Zhang, Tao

    2015-06-30

    The proteins of the Inhibitor of Growth (ING) candidate tumor suppressor family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 is the new member of the family whose actual role in tumor suppression is not known. Here we show that ING5 overexpression in lung cancer A549 cells inhibited cell proliferation and invasiveness, while ING5 knockdown in lung cancer H1299 cells promoted cell aggressiveness. ING5 overexpression also abrogated tumor growth and invasive abilities of lung cancer cells in mouse xenograft models. Further study showed that ING5 overexpression inhibited EMT indicated by increase of E-cadherin and decrease of N-cadherin, Snail and slug at mRNA and protein levels, which was accompanied with morphological changes. cDNA microarray and subsequent qRT-PCR validation revealed that ING5 significantly downregulated expression of EMT (epithelial to mesenchymal transition)-inducing genes including CEACAM6, BMP2 and CDH11. Clinical study by tissue microarray showed that nuclear ING5 negatively correlated with clinical stages and lymph node metastasis of lung cancer. Furthermore, high level of nuclear ING5 was associated with a better prognosis. Taken together, these findings uncover an important role for ING5 as a potent tumor suppressor in lung cancer growth and metastasis.

  9. LACEwING: LocAting Constituent mEmbers In Nearby Groups

    Science.gov (United States)

    Riedel, Adric R.

    2016-01-01

    LACEwING (LocAting Constituent mEmbers In Nearby Groups) uses the kinematics (positions and motions) of stars to determine if they are members of one of 10 nearby young moving groups or 4 nearby open clusters within 100 parsecs. It is written for Python 2.7 and depends upon Numpy, Scipy, and Astropy (ascl:1304.002) modules. LACEwING can be used as a stand-alone code or as a module in other code. Additional python programs are present in the repository for the purpose of recalibrating the code and producing other analyses, including a traceback analysis.

  10. Queer(y)ing and Recrafting Agency: Moving Away from a Model of Coercion versus Escape

    Science.gov (United States)

    Gowlett, Christina

    2014-01-01

    This paper applies a Butlerian-inspired "queer(y)ing" methodology to disrupt the utility of agency being framed within the binary of escape and coercion. In particular, it uses Butler's concept of performative resignification to analyse how Simon, a 16-year-old white male student, maneouvres his way through the social conventions of…

  11. Queer(y)ing and Recrafting Agency: Moving Away from a Model of Coercion versus Escape

    Science.gov (United States)

    Gowlett, Christina

    2014-01-01

    This paper applies a Butlerian-inspired "queer(y)ing" methodology to disrupt the utility of agency being framed within the binary of escape and coercion. In particular, it uses Butler's concept of performative resignification to analyse how Simon, a 16-year-old white male student, maneouvres his way through the social conventions of…

  12. Queer(y)ing Religion and Spirituality: Reflections from Difficult Dialogues Exploring Religion, Spirituality, and Homosexuality

    Science.gov (United States)

    LePeau, Lucy

    2007-01-01

    This article describes a student affairs practitioner's experience with co-instructing a course entitled, "Queer(y)ing Religion and Spirituality". The ways practitioners can facilitate difficult dialogues with students about the intersection of spirituality and GLBT issues are explored.

  13. De-Pake-ing transform analysis of fully deuterated malonic acid.

    Science.gov (United States)

    Elliott, Douglas W; Niemczura, Walter P; Kumashiro, Kristin K

    2009-09-01

    The analysis of deuterium wideline NMR spectra has been an essential step in characterizing the dynamics of molecules in the solid-state. Although clearly important, the identification of quadrupolar coupling constants (QCCs) from the powder patterns is often complicated by poor sensitivity and/or spectral overlap. Previously, others have demonstrated the utility of "de-Pake-ing", a mathematical transform that yields the QCCs in a straightforward manner for symmetric (eta=0) sites. In this short paper, we describe our analysis of a powder sample of perdeutero-malonic acid, a molecule with two distinct deuteron environments and asymmetries. The methylene sites are immediately amenable to the standard de-Pake-ing transform analysis due to their low asymmetry. However, the de-Pake-ing methodology for the acid deuterons, for which the asymmetry deviates significantly from zero, requires more analysis to extract their QCCs. The impact of this work on the future application of de-Pake-ing to a wider range of samples is also discussed.

  14. BE-ing @Work: Wearables and Presence of Mind in the Workplace

    Science.gov (United States)

    Forbes Oste, Heidi

    2016-01-01

    Expectations and demands in the changing contemporary workplace are driven by emergent technologies. Ubiquitous in nature, they are designed to enhance human and organization potential. These technologies provide access to information and connection at all times. They are increasingly reliant on human relationships and connection. BE-ing one's…

  15. Discurso del Ing. Rolando Carrión Muñoz

    OpenAIRE

    Carrión Muñoz, Rolando; Universidad Nacional Mayor de San Marcos

    2014-01-01

    Discurso del Ing. Rolando Carrión Muñoz, con motivo del reconocimiento de la calidad académica otorgada por el Consejo Nacional de Acreditación Universitaria, a la EAP de Ingeniería Industrial de la UNMSM (24 de abril de 2014)

  16. Expression of HIF-1A/VEGF/ING-4 Axis in Pulmonary Sarcoidosis.

    Science.gov (United States)

    Piotrowski, W J; Kiszałkiewicz, J; Pastuszak-Lewandoska, D; Górski, P; Antczak, A; Migdalska-Sęk, M; Górski, W; Czarnecka, K H; Domańska, D; Nawrot, E; Brzeziańska-Lasota, E

    2015-01-01

    Angiogenesis/angiostasis regulated by hypoxia inducible factor-1A (HIF-1A)/vascular endothelial growth factor (VEGF)/inhibitor of growth protein 4 (ING-4) axis may be crucial for the course and outcome of sarcoidosis. Overexpression of angiogenic factors (activation of VEGF through HIF-1A) may predispose to chronic course and lung fibrosis, whereas immunoangiostasis (related to an overexpression of inhibitory ING-4) may be involved in granuloma formation in early sarcoid inflammation, or sustained or recurrent formation of granulomas. In this work we investigated gene expression of HIF-1A, VEGF and ING-4 in bronchoalveolar fluid (BALF) cells and in peripheral blood (PB) lymphocytes of sarcoidosis patients (n=94), to better understand mechanisms of the disease and to search for its biomarkers. The relative gene expression level (RQ value) was analyzed by qPCR. The results were evaluated according to the presence of lung parenchymal involvement (radiological stage I vs. II-IV), acute vs. insidious onset, lung function tests, calcium metabolism parameters, percentage of lymphocytes (BALL%) and BAL CD4+/CD8+ in BALF, age, and gender. In BALF cells, the ING-4 and VEGF RQ values were increased, while HIF-1A expression was decreased. In PB lymphocytes all studied genes were overexpressed. Higher expression of HIF-1A in PB lymphocytes of patients with abnormal spirometry, and in BALF cells of patients with lung volume restriction was found. VEGF gene expression in BALF cells was also higher in patients with abnormal spirometry. These findings were in line with previous data on the role of HIF-1A/VEGF/ING-4 axis in the pathogenesis of sarcoidosis. Up-regulated HIF-1A and VEGF genes are linked to acknowledged negative prognostics.

  17. Pouvoirs urbains et ingénieurs de l’État

    Directory of Open Access Journals (Sweden)

    Sébastien Gardon

    2007-10-01

    Full Text Available Dans cet article, notre intérêt porte sur la conception et la réalisation des grands programmes d’aménagement routier pour comprendre les évolutions du système de décision local et les relations centre - périphérie. L’objectif est de dépasser les visions stato-centrées, qui envisagent la construction des grandes infrastructures routières sous l’angle d’un État central équipant et modernisant la France à partir de Paris. La description des évolutions historiques, que nous avons esquissée, montre trois configurations d’acteurs différentes au niveau de l’aménagement routier de la région lyonnaise. Une première période, l’entre-deux guerres, est marquée par le dynamisme local, symbolisé par l’indépendance technique et financière des collectivités locales à travers la figure des ingénieurs en chef des services techniques municipaux et du service vicinal. Puis s’ouvre une phase de rapatriement de ces problématiques dans le giron de l’État dès la fin des années 1930, confirmée après la seconde guerre mondiale, avec une expertise monopolisée par les Ponts et Chaussées. Enfin à partir des années 1980, les enjeux sont de nouveau focalisés au niveau local, mais avec une échelle territoriale et politique différente de celle connue pendant l’entre-deux guerres.The paper deals with the conception and realization of road building plans as a lens to understand changes in local decision-making and the relations between municipalities and the state. My purpose is to go beyond the usual studies of road constructions as a central state decision to equip and modernize France from the capital. The analysis of historical events shows three main actors for road construction in Lyon. The interwar period relates to a period of municipal dynamism with the financial and technical autonomy of local authorities through the figure of the local engineer. Then, another period begins with the late of the 1930s and

  18. Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling.

    Science.gov (United States)

    Wang, Jiaojiao; Liu, Zhiping; Feng, Xiaojun; Gao, Si; Xu, Suowen; Liu, Peiqing

    2014-11-15

    Cardiac hypertrophy, an adaptive growth process that occurs in response to various pathophysiological stimuli, constitutes an important risk factor for the development of heart failure. However, the molecular mechanisms that regulate this cardiac growth response are not completely understood. Here we revealed that ING3 (inhibitor of growth family, member 3), a type II tumor suppressor, plays a critical role in the regulation of cardiac hypertrophy. ING3 expression was present in relatively high abundance in the heart, and was prominently upregulated in hypertrophic agonists angiotensin II (Ang II), phenylephrine (PE), or isoproterenol (ISO)-stimulated cardiomyocytes and in hearts of rat undergoing abdominal aortic constriction (AAC) surgery. In cardiomyocytes, overexpression of ING3 caused an increase in ANP, BNP and β-MHC mRNA levels and cell surface area, while depletion of ING3 attenuated PE-induced cardiomyocyte hypertrophy. Mechanistically, we have demonstrated that overexpression of ING3 could inactivate the AMPK and activate the canonical p38 MAPK signaling. Remarkably, AMPK agonist AICAR or p38 MAPK inhibitor SB203580 abrogated ING3-induced hypertrophic response in cardiomyocytes. In summary, our data disclose a novel role of ING3 as an inducer of pathological cardiac hypertrophy, suggesting that silencing of ING3 may be explored as a potential therapeutic target in preventing cardiac hypertrophy.

  19. Excel pour l'ingénieur bases, graphiques, calculs, macros, VBA

    CERN Document Server

    Bellan, Philippe

    2010-01-01

    Excel, utilisé par tout possesseur d'un ordinateur personnel pour effectuer des manipulations élémentaires de tableaux et de chiffres, est en réalité un outil beaucoup plus puissant, aux potentialités souvent ignorées. A tous ceux, étudiants scientifiques, élèves-ingénieurs ou ingénieurs en exercice qui pensaient le calcul numérique seulement possible à travers des logiciels lourds et coûteux, ce livre montrera qu'un grand nombre de problèmes mathématiques courants de l'ingénieur peuvent être résolus numériquement en utilisant les outils de calcul et la capacité graphique d'Excel. A cet effet, après avoir introduit les notions de base, l'ouvrage décrit les fonctions disponibles avec Excel, puis quelques méthodes numériques simples permettant de calculer des intégrales, de résoudre des équations différentielles, d'obtenir les solutions de systèmes linéaires ou non, de traiter des problèmes d'optimisation... Les méthodes numériques présentées, qui sont très simples, peuvent...

  20. The 'Techniques de l'ingénieur' available online at CERN!

    CERN Multimedia

    2001-01-01

    Those already familiar with 'Techniques de l'ingénieur' will be delighted. This engineering technology database widely known among French-speaking engineers and technicians can now be consulted online from the CERN Intranet until the end of the summer. To access this database of reference articles in French, all you need to do is go to the CERN Library's Web pages (http://library.cern.ch) and click on the 'Techniques de l'ingénieur' link under the 'News' heading. The Library will be monitoring the use of the database for a couple of months, at the end of which an access licence may be negotiated. Don't hesitate to use it because the decision whether or not to purchase it will depend on the extent to which it is used. The Library is seeking partners within the Laboratory to finance the purchase if it is decided to go ahead with it. Contributions from the CERN community are therefore welcome. For those who are not yet familiar with it, the 'Techniques de l'ingénieur' database ...

  1. Loss of inhibitor of growth (ING-4) is implicated in the pathogenesis and progression of human astrocytomas.

    Science.gov (United States)

    Klironomos, George; Bravou, Vasiliki; Papachristou, Dionysios J; Gatzounis, George; Varakis, John; Parassi, Ekaterini; Repanti, Maria; Papadaki, Helen

    2010-03-01

    Inhibitor of growth 4 (ING-4) is a tumor suppressor gene that interacts with nuclear factor-kappaB (NF-kappaB) and represses its transcriptional activity. Several lines of evidence suggest that the tumor suppressor gene ING-4, the transcription factor NF-kappaB and its target genes matrix metalloproteases MMP-2, MMP-9 and urokinase plasminogen activator (u-PA) are critically involved in tumor invasion. The aim of the present study was to investigate immunohistochemically the expression pattern of ING-4, NF-kappaB and the NF-kappaB downstream targets MMP-2, MMP-9 and u-PA in human astrocytomas from 101 patients. We found that ING-4 expression was significantly decreased in astrocytomas, and ING-4 loss was associated with tumor grade progression. Expression of p65, a NF-kappaB subunit, was significantly higher in grade IV than in grade III and grade I/II tumors, and a statistical significant negative correlation between expression of ING-4 and expression of nuclear p65 was noticed. MMP-9, MMP-2 and u-PA were overexpressed in human astrocytomas. Of note, astrocytomas of advanced histologic grades (grade III, IV) displayed significantly higher expression levels of these proteins compared to tumors of lower grades (grade I, II). Collectively, our data suggest an essential role for ING-4 in human astrocytoma development and progression possibly through regulation of the NF-kappaB-dependent expression of genes involved in tumor invasion.

  2. 人骨髓间质干细胞ING4基因的克隆及其慢病毒表达载体构建%Cloning of human ING4 drived from MSC and construction of PNL-ING4 Lentiviral vector

    Institute of Scientific and Technical Information of China (English)

    张蕾蕾; 许文荣; 乔纯; 钱晖; 朱伟; 李继刚; 周洪兴; 司煜安; 周宗海; 阴晴

    2007-01-01

    目的:克隆人骨髓间质干细胞ING4(inhibitor of growth famility,member4)基因,构建其慢病毒表达载体PNL-ING4.方法:提取人骨髓间质干细胞(hMSCs)总RNA,经RT-PCR扩增出ING4cDNA,克隆至PMD19-T载体,选择阳性克隆进行酶切鉴定和测序,构建慢病毒表达载体PNL-ING4,用双酶切、基因测序进行鉴定.结果:RT-PCR产物为750 bp的条带,双酶切和基因测序正确.结论:成功从hMSCs克隆了ING4基因并成功构建其慢病毒表达载体PNL-ING4,为进一步研究ING4基因的作用与抗肿瘤机制奠定了基础.

  3. Sobre o interesse sentimental para o ingênuo em Schiller a partir de uma nota sobre Kant

    Directory of Open Access Journals (Sweden)

    Giorgia Cecchinato

    2015-01-01

    Full Text Available O presente artigo tem como objetivo aprofundar a compreensão do conceito de “ingênuo” em Schiller. Mais precisamente pretende-se enfocar o significado e a importância da arte ingênua em relação ao papel formador da arte em geral. Para fazer isso confrontou-se o conceito de ingênuo com a complexa noção kantiana de interesse, retomada de modo indireto no escrito “Sobre a poesia ingênua e sentimental” e apontou-se á importância da teoria dos impulsos de Fichte no desenvolvimento da estética de Schiller.

  4. Investigation of inhibition of adenovims mediated gene ING4 and PTEN to hepatocarcinoma cells%重组腺病毒Ad-ING4和Ad-PTEN抑制肝癌细胞增殖

    Institute of Scientific and Technical Information of China (English)

    姚雷; 曹婧媛; 吴鹏飞; 黄玉洪; 王金志; 杨吉成; 缪竞诚

    2011-01-01

    Objective We use recombinant Ad-ING4 and Ad-PTEN to infect human hepatocarcinoma cell line SMMC-7721 in vitro to test and compare the effects of gene expression of the cells. Methods We use recombinant Ad-ING4 and Ad-PTEN and control virus to infect QBI-293A cells for viral propagation and viral titration. The infective effects of Ad-ING4, Ad-PTEN and control virus were confirmed by fluorescence microscopy. Use Ad-ING4 and Ad-PTEN to infect SMMC-7721 cells and confirm their effects by their apoptotic rate and the results of MTT.Results The apoptotic rate of control virus group is 3.4% ± 1.3%, the Ad-ING4 group is 49. 7% ±4. 8% (P < 0. 01 )and the Ad-PTEN group is 11.4% ± 3.2% (P < 0. 01 ). The cell proliferation of group Ad-ING4 and AdPTEN obviously decreased from 48h to 96h( P <0.05 ). Conclusion The data analysis showed Ad-ING4 and AdPTEN had an inhibitory effect to SMMC-7721 cells especially that of Ad-ING4.%目的 用构建好的重组腺病毒Ad-ING4和Ad-PTEN感染人肝癌SMMC-7721细胞,检验其对细胞的作用.方法 用构建好的重组腺病毒Ad-ING4和Ad-PTEN感染QBI-293A细胞,对病毒进行扩增并测定其效价,荧光显微镜下观察感染效果.用扩增得到的Ad-ING4和Ad-PTEN感染SMMC-7721细胞,流式细胞术及MTT检测作用效果.结果 空腺病毒组的凋亡率为3.4%±1.3%,Ad-ING4组和Ad-PTEN组分别为49.7%±4.8%和11.4%4±3.2%,均显著高于空腺病毒组(P<0.01);Ad-ING4组和Ad-PTEN组的细胞增殖在48~96 h时较正常组明显下降(P<0.05).结论 Ad-ING4和Ad-PTEN对SMMC-7721细胞均有显著抑制作用,尤其是Ad-ING4.

  5. [Comment on “Seismology in the days of old” by Inge Lehmann] The Lehmann discontinuity

    Science.gov (United States)

    Anderson, D. L.; Bolt, B. A.; Morse, S. A.

    Recent reflections by Inge Lehmann on her discovery of the inner core (Eos, January 20, 1987, p. 33; see also Bolt [1987, 1982]) remind us that this outstanding Earth scientist is now in her 100th year. The inner core boundary (ICB) is one of the three great seismic-compositional discontinuities that divide Earth into crust, mantle, core, and inner core. The other two discontinuities are well known by names honoring their discoverers, Andrija Mohorovicic and Beno Gutenberg. In this tradition, it is fitting that the ICB be called the Lehmann Discontinuity in honor of its discoverer.

  6. Professionnalisation en master d'ingénierie, un dispositif pédagogique innovant

    OpenAIRE

    Couturier, Catherine; Zaid, Abdelkarim

    2011-01-01

    International audience; Ce travail rend compte d'un dispositif pédagogique professionnalisant en master d'ingénierie, développant l'autonomie et la reconnaissance du professionnel en formation par rapport à une tâche spécifique. Nous décrivons les origines et caractéristiques d'un dispositif structuré par un apprentissage par problème dans une situation ludique. Le compte rendu de ce dispositif met en évidence un bilan positif pour les étudiants et les enseignants et en esquisse des pistes d'...

  7. LoopIng: a template-based tool for predicting the structure of protein loops.

    KAUST Repository

    Messih, Mario Abdel

    2015-08-06

    Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure. This implies that, unlike the rest of the protein, standard homology modeling techniques are not very effective in modeling their structure. However, loops are often involved in protein function, hence inferring their structure is important for predicting protein structure as well as function.We describe a method, LoopIng, based on the Random Forest automated learning technique, which, given a target loop, selects a structural template for it from a database of loop candidates. Compared to the most recently available methods, LoopIng is able to achieve similar accuracy for short loops (4-10 residues) and significant enhancements for long loops (11-20 residues). The quality of the predictions is robust to errors that unavoidably affect the stem regions when these are modeled. The method returns a confidence score for the predicted template loops and has the advantage of being very fast (on average: 1 min/loop).www.biocomputing.it/loopinganna.tramontano@uniroma1.itSupplementary data are available at Bioinformatics online.

  8. The inhibitor of growth protein 5 (ING5 depends on INCA1 as a co-factor for its antiproliferative effects.

    Directory of Open Access Journals (Sweden)

    Feng Zhang

    Full Text Available The proteins of the Inhibitor of Growth (ING family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. For ING5, its actual role in growth suppression and the necessary partners are not known. In a yeast-two-hybrid approach with human bone marrow derived cDNA, we identified ING5 as well as several other proteins as interaction partners of Inhibitor of cyclin A1 (INCA1 that we previously characterized as a novel interaction partner of cyclin A1/CDK2. ING5 expression in leukemic AML blasts was severely reduced compared to normal bone marrow. In line, ING5 inhibited bone marrow colony formation upon retroviral transduction. However, Inca1(-/- bone marrow colony formation was not suppressed by ING5. In murine embryonic fibroblast (MEF cells from Inca1(+/+ and Inca1(-/- mice, overexpression of ING5 suppressed cell proliferation only in the presence of INCA1, while ING5 had no effect in Inca1(-/- MEFs. ING5 overexpression induced a delay in S-phase progression, which required INCA1. Finally, ING5 overexpression enhanced Fas-induced apoptosis in Inca1(+/+ MEFs, while Inca1(-/- MEFs were protected from Fas antibody-induced apoptosis. Taken together, these results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.

  9. The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway.

    Science.gov (United States)

    Luo, Jingjing; Shah, Sitar; Riabowol, Karl; Mains, Paul E

    2009-02-01

    The inhibitor of growth (ING) family of type II tumor suppressors are encoded by five genes in mammals and by three genes in Caenorhabditis elegans. All ING proteins contain a highly conserved plant homeodomain (PHD) zinc finger. ING proteins are activated by stresses, including ionizing radiation, leading to the activation of p53. ING proteins in mammals and yeast have recently been shown to read the histone code in a methylation-sensitive manner to regulate gene expression. Here we identify and characterize ing-3, the C. elegans gene with the highest sequence identity to the human ING3 gene. ING-3 colocalizes with chromatin in embryos, the germline, and somatic cells. The ing-3 gene is part of an operon but is also transcribed from its own promoter. Both ing-3(RNAi) and ing-3 mutant strains demonstrate that the gene likely functions in concert with the C. elegans p53 homolog, cep-1, to induce germ-cell apoptosis in response to ionizing radiation. Somatically, the ing-3 mutant has a weak kinker uncoordinated (kinker Unc) phenotype, indicating a possible neuronal function.

  10. 非小细胞肺癌中ING1基因的突变分析%Mutation of ING1 Gene in Non-small Cell Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    马华玲; 杨为贵; 朱润庆

    2008-01-01

    目的 探讨生长抑制(inhibitor of growth1,ING1)基因是否在非小细胞肺癌(non-small celllung cancer,NSCLC)中存在突变,以确定该基因在NSCLC发病过程中的作用.方法 选择突变率较高的ING1外显子2,应用聚合酶链反应一单链构象多态性分析(Polymerase Chain Reaction-Single Strandc Conformation Polymorphism,PCR-SSCP)检测73例NSCLC和13例非癌肺组织中ING1的突变情况.结果 未发现所扩增的片段有泳动速率的改变,没有发现额外迁移带.结论 在NSCLC中ING1基因突变很少见,ING1表达产物降低可能发生于转录或转录后水平.

  11. Techniques de l’ingénieur, a long-awaited resource

    CERN Multimedia

    GS Department

    2009-01-01

    Since 1 August 2009, a new online resource Les techniques de l’Ingénieur has been available at CERN: and its corpus of over 4,000 articles covering 11 disciplines is now accessible from your computer. This multidisciplinary database covers many subjects ranging from mechanics to the environment. The articles are written by scientific experts recognized in their fields. Online access includes the archives since 1946; it also serves to monitor the latest trends and innovations, and new industry products. This database is therefore both a valuable resource in past and present scientific and technological information and a tool to observe future developments. Anyone can create a free account on this resource. This account is needed to configure your personal alerts and download pdf files of the documents you are interested in. More information on the Library website. Direct access to the database

  12. La sauvegarde des grandes oeuvres de l'ingénierie du XXème siècle

    CERN Document Server

    Graf, Franz

    2016-01-01

    Consacré à la sauvegarde des grandes oeuvres de l’ingénierie du XXe siècle, ce premier numéro des Cahiers du TSAM explore le devenir de certaines des plus remarquables et emblématiques structures en béton du siècle passé. A travers les fi gures d’héroïques constructeurs, il interroge l’héritage construit des ingénieurs, convoquant les plus audacieux d’entre eux (Freyssinet, Isler, Maillart, Nervi, Vierendeel, etc.). Alors que la sauvegarde de l’architecture du XXe siècle s’est récemment constituée en discipline à part entière, la préservation des ouvrages de l’ingénierie de cette période est encore balbutiante. Considérés trop souvent sous le seul point de vue de la sécurité ou de la maintenance, ces ouvrages s’avèrent parfois de véritables chefs-d’oeuvre, jalons d’un «art de l’ingénieur» à la frontière entre performance technique et beauté plastique. Ces cahiers sont donc l’occasion d’initier, à l’appui d’exemples et de projets de sauvegarde con...

  13. Algõpetuse peajoon ja harupedagoogikad / Sirje Piht, Elve Voltein, Anne Uusen, Inge Timoštšuk

    Index Scriptorium Estoniae

    2012-01-01

    Intervjuu Sirje Pihti ja Anne Uuseniga Tallinna Ülikooli algõpetuse osakonnast, Elve Volteiniga Tartu Ülikooli haridusteaduste instituudi õpetajate seminarist ja Inge Timoštšukiga Tallinna Ülikooli kasvatusteaduste instituudi pedagoogilise praktika keskusest

  14. Queer(y)ing New Schooling Accountabilities through "My School": Using Butlerian Tools to Think Differently about Policy Performativity

    Science.gov (United States)

    Gowlett, Christina

    2015-01-01

    This article takes the role of provocateur to "queer(y)" the rules of intelligibility surrounding new schooling accountabilities. Butler's work is seldom used outside the arena of gender and sexualities research. A "queer(y)ing" methodology is subsequently applied in a context very different to where it is frequently…

  15. Reflections on the Grammatical Category of "Before" "After" and "Since" Introducing Non-Finite "-ing" Clauses: A Corpus Approach

    Science.gov (United States)

    He, Qingshun

    2016-01-01

    English language learners may be confused in identifying the grammatical category of such conjunctive expressions as "before," "after" and "since" introducing non-finite "-ing" clauses. In this article, we will conduct a corpus-based investigation of hypotactic conjunctions and conjunctive prepositions…

  16. The plays of Lillian Hellman, Clifford Odets and William Inge on Slovene stages

    Directory of Open Access Journals (Sweden)

    Mateja Slunjski

    2002-12-01

    Full Text Available After the Second World War, Slovene theatres started to include in their repertoires more and more American authors and their plays. Their choice were varied, from serious dramas by Eugene O'Neill, Tennessee Williams and Arthur Miller, to comedies by Norman Krasna and John Van Druten dependant mostly on the availability of the texts. In the immediate postwar years the theatres liked to present playwrights with progressive ideas in their plays, such as Lillian Hellman and her "The Little Foxes", which was successfully produced at three Slovene theatres, while her "The Children's Hour" received negative reviews. In the fifties, three theatres chose two plays by Clifford Odets, "Golden Boy" and "Country Girl", mainly because of his socially critical ideas and his admiration of humanity. His plays were rather well received; however, the critics doubted his literary genius. William Inge and his plays, "Come Back, Little Sheba", "Picnic" and "Bus Stop", chosen mainly because of the warmth with which the author depicted the tragedy and the beauty of life, were produced at three Slovene theatres. The author received rather wide-ranging opinions from the critics. Some thought him to be an unoriginal depicter of dull American life, while others praised his lyricism and new dramatic techniques.

  17. Enzymatic biosensors based on ingá-cipó peroxidase immobilised on sepiolite for TBHQ quantification.

    Science.gov (United States)

    Regina de Oliveira, Tássia; Grawe, Gregory Ferreira; Moccelini, Sally Katiuce; Terezo, Ailton J; Castilho, Marilza

    2014-05-07

    Sepiolite clay mineral was used as a support for the immobilisation of the peroxidase enzyme from ingá-cipó (Inga edulis Mart.) and was used with graphite powder, multi-walled carbon nanotubes (CNTs), mineral oil, and nafion 0.5% (v/v) in the development of a new biosensor for the determination of the antioxidant tert-butylhydroquinone (TBHQ) by square-wave voltammetry (SWV). For the optimisation and application of the biosensor, several parameters were investigated to determine the optimum experimental conditions using SWV. The best performance was obtained using a 0.1 mol L(-1) phosphate buffer solution (pH 7.0), 4.0 × 10(-4) mol L(-1) hydrogen peroxide, a frequency of 50 Hz, a pulse amplitude of 60 mV, and a scan increment of 6 mV. The biosensor showed good repeatability and reproducibility and remained stable for a period of 20 weeks. The analytical curve revealed a linear response range of 1.65 to 9.82 mg L(-1) (r = 0.994) with detection and quantification limits of 0.41 and 1.25 mg L(-1). A recovery study of TBHQ in salad dressing samples yielded values from 99.6-104.8%. The proposed biosensor was successfully used for the determination of TBHQ in commercial salad dressing samples, giving a relative error of 5.4% in relation to the comparative method (chromatographic).

  18. ING-1(heMAb, a Monoclonal Antibody to Epithelial Cell Adhesion Molecule, Inhibits Tumor Metastases in a Murine Cancer Model

    Directory of Open Access Journals (Sweden)

    Harry H. Ruan

    2003-11-01

    Full Text Available ING-1(heMAb, a human-engineered monoclonal antibody (MAb that specifically targets the epithelial cell adhesion molecule (Ep-CAM, kills adenocarcinoma cells in vitro and inhibits tumor growth in vivo. In the current study, we evaluated the efficacy of ING-1(heMAb in a murine model of cancer metastases. Mice received intravenous dosing of 1 mg/kg ING-1(heMAb, twice a week, starting on day 2 or day 5. A negative control group received 1 mg/kg human immunoglobulin G with the same dose frequency starting on day 2. A positive control group received weekly 100 mg/kg 54lurouracil/leucovorin starting on day 2. ING-1(heMAb/day 2 treatment significantly reduced both the number of visible tumor nodules in body cavities (P < .01 and the number of metastases on lung surfaces (P < .005. The treatment also resulted in a 91% reduction of micrometastases in lung tissues (P <.0001. Delaying ING-1(heMAb treatment until day 5 caused 54% reduction in micrometastases (P <.005. Our results indicate that a number of parameters, including treatment starting day, dose level, and dose frequency, are critical in achieving the optimal efficacy of ING-1(heMAb. We conclude that ING-1(heMAb effectively reduced tumor metastases in a murine cancer model. Immunotherapy with ING-1(heMAb may be beneficial in treating human metastatic diseases.

  19. 'HESPERIA' HORIZON 2020 project: High Energy Solar Particle Events foRecastIng and Analysis

    Science.gov (United States)

    Malandraki, Olga; Klein, Karl-Ludwig; Vainio, Rami; Agueda, Neus; Nunez, Marlon; Heber, Bernd; Buetikofer, Rolf; Sarlanis, Christos; Crosby, Norma; Bindi, Veronica; Murphy, Ronald; Tyka, Allan J.; Rodriguez, Juan

    2016-04-01

    Solar energetic particles (SEPs) are of prime interest for fundamental astrophysics. However, due to their high energies they are a space weather concern for technology in space as well as human space exploration calling for reliable tools with predictive capabilities. The two-year EU HORIZON 2020 project HESPERIA (High Energy Solar Particle Events foRecastIng and Analysis, http://www.hesperia-space.eu/) will produce two novel operational SEP forecasting tools based upon proven concepts (UMASEP, REleASE). At the same time the project will advance our understanding of the physical mechanisms that result into high-energy SEP events through the systematic exploitation of the high-energy gamma-ray observations of the FERMI mission and other novel published datasets (PAMELA, AMS), together with in situ SEP measurements near 1 AU. By using multi-frequency observations and performing simulations, the project will address the chain of processes from particle acceleration in the corona, particle transport in the magnetically complex corona and interplanetary space to their detection near 1 AU. Furthermore, HESPERIA will explore the possibility of incorporating the derived results into future innovative space weather services. Publicly available software to invert neutron monitor observations of relativistic SEPs to physical parameters, giving information on the high-energy processes occurring at or near the Sun during solar eruptions, will be provided for the first time. The results of this inversion software will complement the space-borne measurements at adjacent higher energies. In order to achieve these goals HESPERIA will exploit already existing large datasets that are stored into databases built under EU FP7 projects NMDB and SEPServer. The structure of the HESPERIA project, its main objectives and forecasting operational tools, as well as the added value to SEP research will be presented and discussed. Acknowledgement: This project has received funding from the

  20. Evaluating clinical abdominal scoring system in predict- ing the necessity of laparotomy in blunt abdominal trauma

    Directory of Open Access Journals (Sweden)

    Erfantalab-Avini Peyman

    2011-06-01

    Full Text Available 【Abstract】 Objectives: Trauma is among the lead- ing causes of death. Medical management of blunt abdomi- nal trauma (BAT relies on judging patients for whom lap- arotomy is mandatory. This study aimed to determine BAT patients’ signs, as well as paraclinical data, and to clarify the accuracy, sensitivity, specificity, positive and negative predictive value of clinical abdominal scoring system (CASS, a new scoring system based on clinical signs, in predicting whether a BAT patient needs laparotomy or not. Methods: Totally 400 patients suspected of BAT that arrived at the emergency department of two university hos- pitals in Tehran from March 20, 2007 to March 19, 2009 were included in this study. They were evaluated for age, sex, type of trauma, systolic blood pressure, Glasgow coma scale (GCS, pulse rate, time of presentation after trauma, abdomi- nal clinical findings, respiratory rate, temperature, hemoglo- bin (Hb concentration, focused abdominal sonography in trauma (FAST and CASS. Results: Our measurements showed that CASS had an accuracy of 94%, sensitivity of 100%, specificity of 88%, positive predictive value of 90% and negative predictive value of 100% in determining the necessity of laparotomy in BAT patients. Moreover, in our analysis, systolic blood pressure, GCS, pulse rate, Hb concentration, time of presen- tation after trauma, abdominal clinical findings and FAST were also shown to be helpful in confirming the need for laparotomy (P<0.05. Conclusion: CASS is a promising scoring system in rapid detection of the need for laparotomy as well as in minimizing auxiliary expense for further evaluation in BAT patients, thus to promote the cost-benefit ratio and accu- racy of diagnosis. Key words: Abdominal injuries; Laparotomy; Patients; Wounds, nonpenetrating

  1. 抑癌基因ING1在胃癌组织中的表达及其意义

    Institute of Scientific and Technical Information of China (English)

    徐刚; 贺修桃; 聂长庆; 贺修胜; 苏坚; 李艳兰; 容映晖

    2004-01-01

    目的 探索ING1在胃癌组织中的表达及其意义。方法 采用免疫组化法检测51例胃癌组织及15例正常胃粘膜中p33ING1b的表达情况。结果 p33ING1b在胃癌组织中的表达率为41.2%(21/51)。远低于在正常胃粘膜中的表达率100%(15/15)。结论 ING1是抑癌基因,其蛋白产物p33ING1b在胃癌组织中低表达,对胃癌的发生、发展可能起重要作用。

  2. Démarche d'Ingénierie Système pour les systèmes de management

    OpenAIRE

    Bron, Jean-Yves; Salzemann, Bruno

    2015-01-01

    International audience; Le pôle AIP-PRIMECA Lorraine est un centre de ressources de l'Université de Lorraine, il met à disposition des filières de formation des plateformes à caractères industriels. Dans cette publication, nous proposons une démarche d'ingénierie d'un processus de son système de management. L'originalité de notre contribution repose principalement sur l'usage de méthodologies issues de l'Ingénierie des Systèmes Complexes pour la conception d'un processus d'un système de manag...

  3. Ingénierie des compétences et scénarisation pédagogique

    OpenAIRE

    Violaine Page-Lamarche; Josianne Basque; Richard Hotte; Diane Ruelland

    2007-01-01

    [Français] Cet article décrit un processus d’ingénierie éducative orienté compétences d’une activité d’autoévaluation et son intégration à un scénario pédagogique de cours à distance. Cette description est documentée par deux cas d’application dans un contexte de formation universitaire à distance. Le travail d’ingénierie utilise une approche en autogestion des compétences pour concevoir l’activité d’autoévaluation et l’instrumentaliser avec l’outil logiciel web d’autodiagnostic des compétenc...

  4. Deployable centralizers

    Energy Technology Data Exchange (ETDEWEB)

    Grubelich, Mark C.; Su, Jiann-Cherng; Knudsen, Steven D.

    2017-02-28

    A centralizer assembly is disclosed that allows for the assembly to be deployed in-situ. The centralizer assembly includes flexible members that can be extended into the well bore in situ by the initiation of a gas generating device. The centralizer assembly can support a large load carrying capability compared to a traditional bow spring with little or no installation drag. Additionally, larger displacements can be produced to centralize an extremely deviated casing.

  5. Ingénierie des compétences et scénarisation pédagogique

    Directory of Open Access Journals (Sweden)

    Josianne Basque

    2007-01-01

    Full Text Available Cet article décrit un processus d’ingénierie éducative orienté compétences d’une activité d’autoévaluation et son intégration à un scénario pédagogique de cours à distance. Cette description est documentée par deux cas d’application dans un contexte de formation universitaire à distance. Le travail d’ingénierie utilise une approche en autogestion des compétences pour concevoir l’activité d’autoévaluation et l’instrumentaliser avec l’outil logiciel web d’autodiagnostic des compétences, appelé Compétences+. Cet acte d’ingénierie pédagogique porte l’attention de l’enseignant-concepteur sur une démarche centrée sur l’apprentissage dans une perspective d’autogestion des connaissances et de sa validation dans un usage en contexte isomorphe à une situation professionnelle réelle.

  6. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.

    Science.gov (United States)

    Yan, Ruorong; He, Lin; Li, Zhongwu; Han, Xiao; Liang, Jing; Si, Wenzhe; Chen, Zhe; Li, Lei; Xie, Guojia; Li, Wanjin; Wang, Peiyan; Lei, Liandi; Zhang, Hongquan; Pei, Fei; Cao, Dengfeng; Sun, Luyang; Shang, Yongfeng

    2015-03-15

    Loss of function/dysregulation of inhibitor of growth 4 (ING4) and hyperactivation of NF-κB are frequent events in many types of human malignancies. However, the molecular mechanisms underlying these remarkable aberrations are not understood. Here, we report that ING4 is physically associated with JFK. We demonstrated that JFK targets ING4 for ubiquitination and degradation through assembly of an Skp1-Cul1-F-box (SCF) complex. We showed that JFK-mediated ING4 destabilization leads to the hyperactivation of the canonical NF-κB pathway and promotes angiogenesis and metastasis of breast cancer. Significantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas. Our study identified SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-κB axis as an important player in the development and progression of breast cancer, supporting the pursuit of JFK as a potential target for breast cancer intervention.

  7. Spatial object model[l]ing in fuzzy topological spaces : with applications to land cover change

    NARCIS (Netherlands)

    Tang, Xinming

    2004-01-01

    The central topic of this thesis focuses on the accommodation of fuzzy spatial objects in a GIS. Several issues are discussed theoretically and practically, including the definition of fuzzy spatial objects, the topological relations between them, the modeling of fuzzy spatial objects, the generatio

  8. Initier au projet par le jeu. Evaluation d’une expérimentation en école d’ingénieurs

    Directory of Open Access Journals (Sweden)

    Caroline Verzat

    2009-09-01

    Full Text Available Cette communication s’appuie sur une recherche-action menée à l’automne 2006 auprès des élèves ingénieurs de l’Ecole Centrale de Lille (Bac + 3 et 4. Elle évalue l’impact d’un jeu de construction utilisant des spaghettis sur la capacité des équipes d’étudiants à émettre des idées créatives, à constituer des groupes, à gérer leurs relations au sein de ces groupes et à apprendre de leurs expériences. L’impact du jeu est mesuré par l’analyse des retours d’expérience en séance, puis par le suivi des équipes de projet réel qui démarrent ensuite. Sont examinés la composition des équipes, l’origine des sujets six semaines plus tard, puis les auto-évaluations du travail en équipe au bout de trois mois.This paper is based on an action-research, conducted with students in engineering at the Ecole Centrale de Lille in 2006. The aim of this paper is to evaluate the effects of a construction game using spaghettis on the students’ capacity to suggest creative ideas, to build and manage their team work and to learn from experience. These effects are measured through the immediate feedbacks on the game and the management of real project teams after the game. Items such as the composition of the teams, the origins of their subject six weeks later and self-evaluations of team management after 3 month are examined.

  9. Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.

    Science.gov (United States)

    Zhang, Xin; Lin, Dao-Hong; Jin, Yan; Wang, Ke-Sheng; Zhang, Yan; Babilonia, Elisa; Wang, Zhijian; Wang, Zhiqin; Giebisch, Gerhard; Han, Ze-Guang; Wang, Wen-Hui

    2007-05-29

    Dietary K intake plays an important role in the regulation of renal K secretion: a high K intake stimulates whereas low K intake suppresses renal K secretion. Our previous studies demonstrated that the Src family protein-tyrosine kinase and mitogen-activated protein kinase (MAPK) are involved in mediating the effect of low K intake on renal K channels and K secretion. However, the molecular mechanism by which low K intake stimulates MAPK is not completely understood. Here we show that inhibitor of growth 4 (ING4), a protein with a highly conserved plant homeodomain finger motif, is involved in mediating the effect of low K intake on MAPK. K restriction stimulates the expression of ING4 in the kidney and superoxide anions, and its related products are involved in mediating the effect of low K intake on ING4 expression. We used HEK293 cells to express ING4 and observed that expression of ING4 increased the phosphorylation of p38 and ERK MAPK, whereas down-regulation of ING4 with small interfering RNA decreased the phosphorylation of p38 and ERK. Immunocytochemistry showed that ING4 was expressed in the renal outer medullary potassium (ROMK)-positive tubules. Moreover, ING4 decreased K currents in Xenopus oocytes injected with ROMK channel cRNA. This inhibitory effect was reversed by blocking p38 and ERK MAPK. These data provide evidence for the role of ING4 in mediating the effect of low K intake on ROMK channel activity by stimulation of p38 and ERK MAPK.

  10. OBITUARY: Eur.Ing. Professor David Dew-Hughes in memoriam

    Science.gov (United States)

    Campbell, Archie; Dew-Hughes, Denise; Donaldson, Gordon; Palmer, Richard

    2007-06-01

    We regret to announce the death of David Dew-Hughes, the second Honorary Editor of Superconductor Science and Technology, in Autumn 2006. He was born in Manchester, the eldest of three children, attended Manchester Grammar School and took his first degree in metallurgy at Birmingham, before undertaking a Doctorate of Engineering at Yale University. After initial work for IBM on semiconductors, he returned to England as a lecturer in metallurgy at Cambridge University. There he devoted his career to superconductivity long before it became fashionable, starting a group on the properties of what we now know as type II materials, with his students Jan Evetts, Archie Campbell and Anant Narlikar. Between them they paved the way to our understanding of the magnetic vortex properties of these materials, and thus to the development of modern practical materials for superconducting magnets. Eur.Ing. Professor David Dew-Hughes 1932-2006 In 1965 he became a founding Senior Lecturer in physics at Lancaster University, moving to Brookhaven National Laboratory in 1974. His final academic post was in engineering science at Oxford University where he also held a University College Tutorial Fellowship. As long ago as 1971 David wrote an authoritative review for Reports on Progress in Physics on 'The metallurgical enhancement of type II superconductors'. Following the discovery of high-Tc superconductivity, IOP Publishing launched Superconductor Science and Technology in 1988 and he was a founder member of its Editorial Board. When Jan Evetts retired as Honorary Editor in 1992, David was the natural choice as his successor. He served a five year term and remained on the Board as Deputy Editor until the end of 2000. To mark the 10th anniversary of high-temperature superconductivity in 1997, David edited a special issue of Superconductor Science and Technology in which past and present members of the Editorial Board contributed reviews of their specialities. He noted that at that time

  11. 实时RT-PCR与半定量RT-PCR检测胃腺癌中ING4表达的比较研究

    Institute of Scientific and Technical Information of China (English)

    刘丹; 李明; 傅松滨

    2007-01-01

    目的 探讨Real-time RT-PCR和半定量RT-PCR在检测胃腺癌中ING4 mRNA表达的特异性、敏感性和灵敏度的差别.方法 本实验采用半定量RT-PCR法和Real-time RT-PCR法分别检测13例胃腺癌及癌旁组织ING4 mRNA的表达.结果 两种PCR法均可验证胃腺癌组织ING4 mRNA表达量低于癌旁组织,有统计学意义.结论 Real-time RT-PCR检测ING4 mRNA在胃腺癌中表达的结果更为可靠、更为灵敏.

  12. From the Borrowing Bound Morpheme -ing to Chinese Typology%由ing想到的汉语形态的变化

    Institute of Scientific and Technical Information of China (English)

    赵一农

    2014-01-01

    当代汉语里出现了英语粘着语素ing,主要流行于网络世界的写作。 ing比较独特,因为汉语稀有外来虚词和屈折语素。 ing为汉语带来一个新的语言现象,它是低于单词层面上的迁移,是个屈折粘着后缀语素,是个系统语素,具有表达语法意义的功能。在未来,ing可能会与“正在”形成弱互补关系,这种互补关系在其他语言里也存在。由ing想到汉语的形态,由于汉语粘着语素在不断增加,汉语出现了朝粘着语方向发展的苗头。 ing值得从描述语言学角度加以研究。%The English bound morpheme-ing appears in contemporary Chinese though its use is mainly confined to the computer-medi-ated communication. -ing is unique in that Chinese has very few foreign function words and inflectional morphemes. As a sub-word transfer from English,-ing brings a new linguistic phenomenon to Chinese because it is an inflectional suffix and a system morpheme which expresses a grammatical meaning. In the future, -ing will probably enter into weak complementarity with “zhengzai” (正在) which can be found in other languages. -ing provides food for thought about Chinese typology.-ing can be regarded kind of a herald of a new development in Chinese toward agglutinative language. Besides, the number of bound morphemes in Chinese is on the increase. Linguistically,-ing deserves a descriptive study.

  13. Implementing Electronic Patient Record and VIPS in medical hospital wards: Evaluating change in quantity and quality of nursing documentation by using the audit instrument Cat-ch-Ing

    OpenAIRE

    Rykkje, Linda

    2009-01-01

    Aim: The study examines the effectiveness of implementation of electronic nursing documentation and the nursing documentation system VIPS at the Department of Medicine, and also aims to improve our understanding of content and quality in nursing documentation. Background: After introducing Electronic Patient Record (EPR) and VIPS to medical wards, change in the quantity and quality of nursing documentation was evaluated by using the audit instrument Cat-ch-Ing. Method: Cat-ch-Ing ...

  14. p33/ING1 and PTEN EXPRESSION IN ESOPHAGUS SCALE CANCER AND ITS SIGNIFICANCE%p33/ING1和PTEN在食管鳞癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    李慧娥; 冷雪芹; 宋光明

    2012-01-01

    目的:研究食管癌病人中p33/ING1和PTEN蛋白的表达及其与食管癌病理特征的关系,探讨食管癌的发病机制,以寻求预防、诊断和治疗食管癌的新方法.方法:采用免疫组织化学技术联合检测PTEN基因、凋亡促进因子p33/ING1在食管鳞癌组织、癌旁不典型增生组织及其相应的正常食管黏膜组织中的表达.结果:p33/ING1和PTEN蛋白从正常黏膜-不典型增生-浸润癌渐进性表达减低(P<0.05),与食管癌分化程度、浸润深度、淋巴结转移有关(P<0.05).PTEN蛋白在食管癌中的低表达与p33/ING1蛋白在其中的表达呈正相关.结论:p33/ING1和PTEN基因的失活(或缺失)及蛋白表达的下降在食管鳞癌的发生、分化及浸润转移过程中起重要作用.两者有可能为临床上食管癌早期诊断、相关治疗及预后研究提供新的手段.%Objective: To study p33/INGl and PTEN protein expression and pathological features of esophageal cancer, and to explore the pathogenesis of esophageal cancer in order to seek prevention, diagnosis and treatment of esophageal cancer in new ways. Method: With immunohistochemical detection of PTEN gene, apoptosis - promoting factor p33/INGl in esophageal squamous cell carcinoma, a-typical hyperplasia adjacent and corresponding normal esophageal mucosa tissue. Results; p33/INGl and PTEN protein in normal mucosa — dysplasia - carcinoma expression of progressive reduction (P<0.05), and esophageal cancer differentiation, depth of invasion, lymph node metastasis (P <0.05 ). PTEN protein expression in esophageal cancer and p33/INGl low expression of protein in which a positive correlation. Conclusion; p33/INGl and PTEN gene inactivation ( or loss) and decreased protein expression in esophageal squamous cell carcinoma, differentiation, invasion and metastasis play an important role. Possible to provide new means for both the clinical diagnosis, treatment and prognosis of esophageal cancer.

  15. 肿瘤抑制因子P33ING1b的研究进展

    Institute of Scientific and Technical Information of China (English)

    贺琪; 陈兴平

    2008-01-01

    生长抑制因子(inhibitor of growth.ING)家族是学者在筛选生长抑制基因的过程中检测到其成员之一的INGl而偶然发现的一个新家族,已被归入肿瘤抑制基因家族这个正在不断发展的群体。该群体的成员含有一系列与转录调控相关的结构序列。能编码相应的蛋白因子。其中,P33INGIb是ING1的蛋白产物之一,具有多种生物学功能。本文收集近年相关资料,就P33ING1b的基因定位、基因结构、功能、故障原因及其与某些皮肤病的关系综述如下.为相关研究及临床应用开拓新思路。

  16. Making Central Banks Serve The Real Economy

    Directory of Open Access Journals (Sweden)

    Suleika Reiners

    2013-10-01

    Full Text Available The challenge is to redirect central bank money into the real economy and to the needs of society. If new money is issued to expand the productive capacity, there is no reason for inflation. Long-term financing could become available at an affordable price. Central bank money must not replace a sound tax system and the distribution of income and wealth, but complement them. The remaining task, apart from the financing of real needs, is the prevention of speculative asset price inflation. For this, central banks and regulators should install debt brakes for the financial sector. Furthermore, independent monetary policy calls for capital account management. It enables national central banks to find space for the conduct of their own policies in an interdependent global economy. Coordination between central banks and governments might increase as policies combine monetary, fiscal and regulatory facets. The future role of central banks should particularly lie in their insights regarding capital flows and leverage cycles and in their ability to create and withdraw money, depend­ing on economic conditions.

  17. Adenovirus-mediated p53 and ING4 gene co-transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.

    Science.gov (United States)

    Wu, Jie; Zhu, Yanbo; Xu, Chun; Xu, Hong; Zhou, Xiumin; Yang, Jicheng; Xie, Yufeng; Tao, Min

    2016-01-01

    Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its transcriptional activity. Hence, we assumed that combined treatment of p53 and ING4 double tumor suppressors would exhibit enhanced antitumor effects. The combined therapeutic efficacy of p53 and ING4 for human cancers has not been previously reported. We thus generated multiple promoter expression cassette-based recombinant adenovirus-co-expressing ING4 and p53 double tumor suppressor genes (AdVING4/p53), evaluated the combined effects of AdVING4/p53 on breast cancer using the MDA-MB-231 (mutant p53) human breast cancer cell line, and also elucidated its underlying molecular mechanisms. We demonstrated that AdVING4/p53-mediated p53 and ING4 co-expression induced synergistic growth inhibition and apoptosis as well as enhanced effects on upregulation of acetylated p53, P21, Bax, PUMA, Noxa, cleaved caspase-9, cleaved caspase-3 and cleaved PARP, and downregulation of Bcl-2, CD31 and microvessel density (MVD) in MDA-MB-231 breast cancer in vitro and/or in vivo subcutaneous (s.c.) xenografted tumors. The synergistic antitumor activity elicited by AdVING4/p53 was closely associated with the enhanced activation of the intrinsic apoptotic pathway and synergistic inhibition of tumor angiogenesis, very possibly via ING4-mediated enhancement of p53 acetylation and activity. Thus, our results indicate that cancer gene therapy combining two or more tumor suppressors such as p53 and ING4 may constitute a novel and effective therapeutic modality for human breast cancer and other cancers.

  18. MUSE-INGS ON AM1354-250: COLLISIONS, SHOCKS, AND RINGS

    Energy Technology Data Exchange (ETDEWEB)

    Conn, Blair C. [Gemini Observatory, Recinto AURA, Colina El Pino, Casilla 603, La Serena (Chile); Fogarty, L. M. R. [Sydney Institute for Astronomy, School of Physics, The University of Sydney, A28, Sydney, 2006 (Australia); Smith, Rory [Yonsei University, Graduate School of Earth System Sciences-Astronomy-Atmospheric Sciences, Yonsei-ro 50, Seoul 120-749 (Korea, Republic of); Candlish, Graeme N., E-mail: bconn@gemini.edu [Departamento de Astronomía, Universidad de Concepción, Casilla 160-C, Concepción (Chile)

    2016-03-10

    We present Multi Unit Spectroscopic Explorer observations of AM1354-250, confirming its status as a collisional ring galaxy that has recently undergone an interaction, creating its distinctive shape. We analyze the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of ∼70 km s{sup −1} and that star formation is occurring primarily in H ii regions associated with the ring. This star formation activity is likely triggered by this interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains a weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated 140 ± 12 Myr ago.

  19. MUSE-ings on AM1354-250: Collisions, Shocks and Rings

    CERN Document Server

    Conn, Blair C; Smith, Rory; Candlish, Graeme N

    2015-01-01

    We present MUSE observations of AM1354-250, confirming its status as a collisional ring galaxy which has recently undergone an interaction, creating its distinctive shape. We analyse the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of $\\sim$70km.s$^{-1}$ and that star formation is occurring primarily in HII regions associated with the ring. This star formation activity is likely triggered by the interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated $140 \\pm 12$ Myr ...

  20. OGLE-ING the Magellanic System: Stellar Populations in the Magellanic Bridge

    Science.gov (United States)

    Skowron, D. M.; Jacyszyn, A. M.; Udalski, A.; Szymański, M. K.; Skowron, J.; Poleski, R.; Kozłowski, S.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Mróz, P.; Pietrukowicz, P.; Ulaczyk, K.; Wyrzykowski, Ł.

    2014-11-01

    We report the discovery of a young stellar bridge that forms a continuous connection between the Magellanic Clouds. This finding is based on number density maps for stellar populations found in data gathered by OGLE-IV that fully cover over 270 deg2 of the sky in the Magellanic Bridge area. This is the most extensive optical survey of this region to date. We find that the young population is present mainly in the western half of the MBR, which, together with the newly discovered young population in the eastern Bridge, form a continuous stream of stars connecting both galaxies along δ ~ -73.5 deg. The young population distribution is clumped, with one of the major densities close to the SMC and the other fairly isolated and located approximately mid-way between the Clouds, which we call the OGLE island. These overdensities are well matched by H I surface density contours, although the newly found young population in the eastern Bridge is offset by ~2 deg north from the highest H I density contour. We observe a continuity of red clump stars between the Magellanic Clouds which represent an intermediate-age population. Red clump stars are present mainly in the southern and central parts of the Magellanic Bridge, below its gaseous part, and their presence is reflected by a strong deviation from the radial density profiles of the two galaxies. This may indicate either a tidal stream of stars, or that the stellar halos of the two galaxies overlap. On the other hand, we do not observe such an overlap within an intermediate-age population represented by the top of the red giant branch and the asymptotic giant branch stars. We also see only minor mixing of the old populations of the Clouds in the southern part of the Bridge, represented by the lowest part of the red giant branch.

  1. Télécoms pour l’ingénierie du risque, Tullio Tanzi, Patrick Perrot

    Directory of Open Access Journals (Sweden)

    Jean-Baptiste Morin

    2013-04-01

    Full Text Available "Télécoms pour l’ingénierie du risque" est un ouvrage de 234 pages qui convoque la rencontre entre les Technologies de l’Information de la Communication (TIC et le risque. Les risques naturels, les risques industriels et technologiques ou encore les nouveaux risques générés par des usages déviants dans le domaine du numérique (cybercriminalité sont devenus monnaie courante. Les auteurs Tullio Tanzi (Professeur à Télécom ParisTech, département Traitement du Signal et des Images en télécommun...

  2. Central line infections - hospitals

    Science.gov (United States)

    ... infection; Central venous catheter - infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired ...

  3. L’ingénierie pédagogique à base d’objets et le référencement par les compétences

    Directory of Open Access Journals (Sweden)

    Gilbert Paquette

    2004-01-01

    Full Text Available Nous situons l’ingénierie pédagogique au confluent du design pédagogique, du génie logiciel et de l’ingénierie cognitive. Puis, dans l’optique d’une ingénierie pédagogique à base d’objets, nous proposons une méthode permettant de représenter graphiquement les connaissances et les compétences, puis de les associer aux ressources d’apprentissage. Par la suite, nous montrons comment cette méthode peut contribuer à améliorer la qualité des environnements en ligne à chacune des phases de leur cycle de vie.

  4. L’ingénierie pédagogique à base d’objets et le référencement par les compétences

    OpenAIRE

    Gilbert Paquette

    2004-01-01

    [Français] Nous situons l’ingénierie pédagogique au confluent du design pédagogique, du génie logiciel et de l’ingénierie cognitive. Puis, dans l’optique d’une ingénierie pédagogique à base d’objets, nous proposons une méthode permettant de représenter graphiquement les connaissances et les compétences, puis de les associer aux ressources d’apprentissage. Par la suite, nous montrons comment cette méthode peut contribuer à améliorer la qualité des environnements en ligne à chacune des phases d...

  5. The expression and significance of p33ING 1 and p53 in age-related cataract%老年性白内障中p33ING 1和p53的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    乔淑琴; 鲁建华; 张文芳

    2009-01-01

    目的 探讨生长抑制基因p33ING 1和肿瘤抑制基因p53在年龄相关性白内障晶状体上皮细胞中的表达,并初步探讨p33ING 1和p53在年龄相关性白内障发病中的作用,进一步展望二者在年龄相关性白内障术后与后发障发生的相关性.方法 30例年龄相关性白内障及10例透明晶状体前囊,应用免疫组织化学法,分别观察对照组和白内障组晶状体上皮细胞中p33ING 1和p53的阳性表达水平.结果 透明晶状体组中p33ING 1和p53极低表达,年龄相关性白内障组中p33ING 1和p53高表达.两组相比较,p33ING 1和p53表达均有显著性差异(P<0.05).对白内障组进行p33ING 1和p53相关性分析,二者有正相关关系.结论 p33ING 1和p53在年龄相关性白内障的形成过程中起重要作用,且二者具有协同作用.

  6. Une expérience pédagogique du débat public en école d'ingénieur. Le cas du nucléaire

    Directory of Open Access Journals (Sweden)

    Colmellere Cynthia

    2014-01-01

    Full Text Available Cette communication présente un dispositif pédagogique d'exercice de débat public autour d'un projet d'implantation d'un réacteur nucléaire. Cet exercice est mené depuis trois ans dans le cadre d'un cours de sociologie pour des ingénieurs de deuxième année à l'Ecole Centrale Paris. Il concerne un groupe d'une vingtaine d'élèves et s'inspire d'une situation réelle et actuelle : le projet d'implantation d'un réacteur nucléaire de type EPR à Penly (76. Dans cette contribution, nous présentons tout d'abord les enjeux de cette expérience pédagogique dans le contexte de notre établissement et les questions pédagogiques qu'elle pose. Dans une deuxième partie, nous détaillons les différentes séquences du cours qui servent à préparer ce débat. Dans la troisième, nous revenons sur le déroulement du débat et la phase de discussion critique entre les observateurs, les élèves et l'enseignante qui s'ensuit. Nous concluons sur les apports et les limites de cet exercice en les mettant en perspective avec les enjeux de l'enseignement des controverses scientifiques et techniques dans la formation des ingénieurs.

  7. Central Solenoid

    CERN Multimedia

    2002-01-01

    The Central Solenoid (CS) is a single layer coil wound internally in a supporting cylinder housed in the cryostat of the Liquid Argon Calorimeter. It was successfully tested at Toshiba in December 2000 and was delivered to CERN in September 2001 ready for integration in the LAr Calorimeter in 2003. An intermediate test of the chimney and proximity cryogenics was successfully performed in June 2002.

  8. Europa central

    Directory of Open Access Journals (Sweden)

    Karel BARTOSEK

    2010-02-01

    Full Text Available La investigación francesa continúa interesándose por Europa Central. Desde luego, hay límites a este interés en el ambiente general de mi nueva patria: en la ignorancia, producto del largo desinterés de Francia por este espacio después de la Segunda Guerra Mundial, y en el comportamiento y la reflexión de la clase política y de los medios de comunicación (una anécdota para ilustrar este ambiente: durante la preparación de nuestro coloquio «Refugiados e inmigrantes de Europa Central en el movimiento antifascista y la Resistencia en Francia, 1933-1945», celebrado en París en octubre de 1986, el problema de la definición fue planteado concreta y «prácticamente». ¡Y hubo entonces un historiador eminente, para quién Alemania no formaría parte de Europa Central!.

  9. Central pain.

    Science.gov (United States)

    Singh, Supreet

    2014-12-01

    Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. The topic addressed in this issue is central pain, a neuropathic pain syndrome caused by a lesion in the brain or spinal cord that sensitizes one's perception of pain. It is a debilitating condition caused by various diseases such as multiple sclerosis, strokes, spinal cord injuries, or brain tumors. Varied symptoms and the use of pharmacological medicines and nonpharmacological therapies will be addressed.

  10. central t

    Directory of Open Access Journals (Sweden)

    Manuel R. Piña Monarrez

    2007-01-01

    Full Text Available Dado que la Regresión Ridge (RR, es una estimación sesgada que parte de la solución de la regresión de Mínimos Cuadrados (MC, es vital establecer las condiciones para las que la distribución central t de Student que se utiliza en la prueba de hipótesis en MC, sea también aplicable a la regresión RR. La prueba de este importante resultado se presenta en este artículo.

  11. Problems and Countermeasures of Colloquial English Large Size Class Teach-ing of Higher Vocational Public English under the Constructivism Theory

    Institute of Scientific and Technical Information of China (English)

    WANG Yan-ping

    2014-01-01

    Based on the theory of constructivism, this article analyzes the open problems colloquial English large size class teach-ing of higher vocational public English and points out the countermeasures of colloquial English large-scale class teaching of high-er vocational public English.

  12. Sure How Would the (Imminent) Future Ever Be after Becoming the (Recent) Past? Change in the Irish English "Be after V-ing" Construction.

    Science.gov (United States)

    McCafferty, Kevin

    This paper examines the written use of the "be after V-ing" construction since the reintroduction of English into Ireland. Information comes from publications beginning in 1670, including 193 works by 87 authors providing 1,316 tokens of the construction. Results support Filppula's (1999) view of historical change in the use of this…

  13. Teeninduse taseme hoidmine ja heade teenindajate leidmine on tööandjatele võtmeküsimus / Anu-Mall Naarits, Anneli Mere, Kristjan Laja, Inge Suder

    Index Scriptorium Estoniae

    2009-01-01

    Anu-Mall Naarits Maratist, Anneli Mere Matkasport OÜ-st, Kristjan Laja Ambient Marketingist ning Inge Suder AS-ist Eesti Post vastavad küsimustele, mis puudutavad tagasisidet teenindusele, teenindajatele pakutavaid koolitusi ja motivatsioonipakette, teeninduse taset Eestis, teenindustöötajate palgataset, hea teenindaja isikuomadusi ning raskemaid ülesandeid teenindaja töös

  14. Tales of Recombinant Femininity: "The Reincarnation of Golden Lotus," the "Chin P'ing Mei," and the Politics of Melodrama in Hong Kong.

    Science.gov (United States)

    Fore, Steve

    1993-01-01

    Examines the film "The Reincarnation of Golden Lotus" and the text upon which it is loosely based, the "Chin P'ing Mei," and the relationship between it and modern Chinese culture. States that the film's screenplay is much less an adaptation of the source novel than it is a female-centered reworking of a particular narrative…

  15. Material development in the SI sub 3 N sub 4 system using glass encapsulated Hip'ing

    Energy Technology Data Exchange (ETDEWEB)

    Corbin, N.D.; Sundberg, G.J.; Siebein, K.N.; Willkens, C.A.; Pujari, V.K.; Rossi, G.A.; Hansen, J.S.; Chang, C.L.; Hammarstrom, J.L.

    1992-04-01

    This report covers a two-year program to develop fully dense Si{sub 3}N{sub 4} matrix SiC whisker composites with enhanced properties over monolithic Si{sub 3}N{sub 4} materials. The primary goal was to develop a composite with a fracture toughness > 10 MPa{radical}m, capable of using high pressure glass encapsulated HIP'ing. Coating methods were developed to apply thin (<150nm) stoichiometric BN layers to SiC whiskers and also to apply a dual coating of SiC over carbon to the whiskers. Fracture toughness of the composites was determined to increase as the quantity of whiskers (or elongated grains) with their axis perpendicular to the crack plane increased. Of the interface compositions evaluated in this effort, carbon was determined to be the most effective for increasing toughness. The highest toughnesses (6.8--7.0 MPa{radical}m) were obtained with uniaxially aligned carbon coated whiskers. There was no evidence of the carbon coating compromising the oxidation resistance of the composites at 1370{degree}C.

  16. Ingénierie de la maintenance De la conception à l'exploitation d'un bien

    CERN Document Server

    Francastel, Jean-Claude

    2003-01-01

    La maintenance a évolué : d’abord confinée à l’entretien des équipements “réparer“ les pannes puis élargie à leur surveillance “prévoir” les pannes elle est intégrée aujourd’hui dès la phase de conception du produit avec notamment le concept de “maintenabilité” du produit. L’ingénierie de maintenance désigne ce processus d’accompagnement d’un bien industriel durant toutes les phases de son cycle de vie de la conception au démantèlement qui permet d’optimiser l’exploitation de ce bien et son coût global life cycle cost. Cet ouvrage décrit les différentes phases du cycle de vie en exposant les techniques qui permettent d’intégrer à chaque étape les concepts de maintenance.

  17. Still Qcd-Ing

    Science.gov (United States)

    Politzer, H. David

    1982-01-01

    In these lectures I have attempted to describe the ideas underlying the most important applications of OCD to high energy physics (as of 1979). The exposition is purposefully informal, in the hope that anyone familiar with Feynman diagrams might profit by a single, casual reading. However, the text is sprinkled with sufficiently many outrageous claims, slanderous libels, and inadequate references that a serious student or even a practicing expert will find much upon which to chew.

  18. Seitsmesed uudised / Inge Pitsner

    Index Scriptorium Estoniae

    Pitsner, Inge

    2008-01-01

    TV 3 uudistetoimetuse vestlusringis on peatoimetaja Märt Treier, toimetajad Sirje Eesmaa ja Sven Soiver, repoterid Allan Muuk ja Helena Veidebaum. Järgneb 10. märts, 2008, lk. 18-19 : ill. ja 17. märts, 2008, lk. 14-15 : ill. Sama ka Teleleht nr. 10, lk. 6-7 : ill. ja nr. 11, lk. 8 : ill ja nr. 12, lk. 10 : ill

  19. Ing. Carlos M. Ochoa

    OpenAIRE

    Montesinos A, Fernando; Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú.

    2014-01-01

    Este personaje es un extraordinario investigador dedicado, durante muchos año, al estudio de la papa, tubérculo del genero Solanum y al infinito número de especies y variedades que cubren los territorios del Perú, Bolivia y Chile, y posiblemente otros países. Originalmente silvestre, hoy como resultado del avance científico constituye un alimento de gran valor en el mundo, desde todo punto de vista.Carlos M. Ochoa nació en el Cusco: se trasladó a Bolivia donde llevó a cabo estudios iniciales,...

  20. Ingênuos e órfãos pobres: a utilização do trabalho infantil no final da escravidão

    Directory of Open Access Journals (Sweden)

    Papali, Maria Aparecida C. R.

    2007-01-01

    Full Text Available A exploração do trabalho do meno, do ingênuo e do orfão desvalido, filhos de libertas e mulheres solteiras pobres foi amplamente difundido entre muitos fazendeiros e membros da elite brasileira no final da escravidão. Ex-senhores de Taubaté amparados pelo judiciário buscaram tutelar os filhos de suas escravas libertas no início de 1888, crianças e jovens que, da condição de ingênuos, foram lançados à condição de orfãos desamparados. Ao serem tutelados, tais menores eram encaminhados ao serviço doméstico ou ao trabalho na lavoura

  1. Hvarf heimsins. Þýðing á fyrri hluta bókarinnar Disappearance of the Universe ásamt greinargerð

    OpenAIRE

    María Ásmundsdóttir Shanko 1978

    2016-01-01

    Þessi meistaraprófsritgerð er þýðing bókarinnar Disapperance of the Universe eftir Bandaríkjamanninn Gary Renard sem hlaut nafnið Hvarf heimsins á íslensku. Umrædd bók fjallar um hið óþýdda kennslurit A Course in Miracles (Námskeið í kraftaverkum), reynslu höfundar af lestri hennar og iðkun æfinga sem þar er að finna. Markmið æfinganna er að breyta viðhorfi, heimsmynd eða lífssýn lesandans, byggðri á ótta egósins, yfir í viðhorf og upplifun einhyggju. Ritgerðin er annars vegar þýðing á fy...

  2. Complete genome sequence of the novel Porphyromonadaceae bacterium strain ING2-E5B isolated from a mesophilic lab-scale biogas reactor.

    Science.gov (United States)

    Hahnke, Sarah; Maus, Irena; Wibberg, Daniel; Tomazetto, Geizecler; Pühler, Alfred; Klocke, Michael; Schlüter, Andreas

    2015-01-10

    In this study, the whole genome sequence of the mesophilic, anaerobic Porphyromonadaceae bacterium strain ING2-E5B (LMG 28429, DSM 28696) is reported. The new isolate belongs to the phylum Bacteroidetes and was obtained from a biogas-producing lab-scale completely stirred tank reactor (CSTR) optimized for anaerobic digestion of maize silage in co-fermentation with pig and cattle manure. The genome of strain ING2-E5B contains numerous genes encoding proteins and enzymes involved in the degradation of complex carbohydrates and proteinaceous compounds. Moreover, it possesses genes catalyzing the production of volatile fatty acids. Hence, this bacterium was predicted to be involved in hydrolysis and acidogenesis during anaerobic digestion and biomethanation.

  3. Mida teed siis, kui töötaja on avaldanud soovi firmast lahkuda? / Inge Rumessen, Andres Hall, Mariliin Saar ... [jt.

    Index Scriptorium Estoniae

    2016-01-01

    Küsimusele vastavad PR Strategies partner ja strateegiline konsultant Inge Rumessen, auto24ring juhataja Andrs Hall, vabakutseline loovjuht ja produtsent Mariliin Saar, advokaadibüroo Tark partner Hannes Küün, ettevõtte Ööloom ja Frank kaasasutaja Jan Plaan, haridus- ja teadusministeeriumi personaliosakonna juhataja Margot Saluse, Sorry as Service müügijuht ja asutaja Indrek Põldvee ja EBS-i rahvusvahelise koostöö prorektor Toomas Danneberg

  4. Estimación de la radiación solar global incidente en superficies inclinadas (ING

    Directory of Open Access Journals (Sweden)

    Jaime Wright

    2016-03-01

    The curves in this paper will be useful for large scale installations of solar collectors or photovoltaic panels in terrain with variable slopes in the geographic regions of the Central Valley (represented by Fabio Baudrit, North Pacific (represented by Santa Rosa, South Pacific (represented by Palmar Sur and the Atlantic (represented by Limón.

  5. COMPARISON OF SE CUR ING (R t IJ V ANATOMICAL LANDMARK TECHNIQUE V/S U. S. GUIDED TECHNIQUE

    Directory of Open Access Journals (Sweden)

    Veeresham

    2015-07-01

    Full Text Available Vascular access of central venous lines especially right internal jugular vein is very commonly performed procedure during the general anaesthesia to monitor the patient’s vascular status, and giving drugs to the patients through these lines. Ultra sound guided technic improves the securing time and minimizes the complications of the surrounding structures both vascular and nerves other important structures in the securing area.

  6. Greining á úrslitum kosningar til stjórnlagaþings 27. nóvember 2010

    Directory of Open Access Journals (Sweden)

    Þorkell Helgason

    2011-06-01

    Full Text Available Í kosningu 27. nóvember 2010 var kosið í 25 sæti til stjórnlagaþings sem halda skal á fyrra hluta ársins 2011. Lög mæla fyrir um að úthlutað skuli allt að 6 sætum að auki í því skyni að hvorugt kynið fari niður fyrir 40% þingfulltrúa. Reyndin varð sú að kjörnir voru 15 karlar og 10 konur og náðist því markmiðið án þess að það reyndi á þetta kynjajöfnunarákvæði. Því verður hér eftir ávallt talað um þingið eins og það sé skipað 25 fulltrúum einvörðungu. Margt var sérstætt við þessa kosningu. Ber þar fyrst að nefna að þetta var landskjör, þ.e. landið var eitt kjördæmi. Framboð voru einstaklingsbundin, engir listar eða annað því um líkt. Því var um hreint persónukjör að ræða. Tiltölulega auðvelt var að uppfylla framboðsskilyrði. Einungis þurfti að fá 30 meðmælendur en að vísu tvo votta með hverri undirskrift, en þeir gátu vottað marga meðmælendur hver. Meðmælendur gátu líka verið vottar að undirskrift annarra meðmælenda. Afleiðingin var sú að 523 buðu sig fram. Einn frambjóðandi dró sig til baka í tæka tíð og annar mun hafa gert það síðar. Í því sem á eftir fer er því miðað við að frambjóðendur hafi verið 522 að tölu. Eitt mikilvægasta nýmælið hérlendis í þessari kosningu var að persónukjörið fór fram með aðferð sem nefnd hefur verið forgangsröðunaraðferð, Single Transferable Vote (STV á ensku.

  7. Des ingénieurs pour un monde nouveau histoire des enseignements électrotechniques (Europe, Amériques) : XIXe-XXe siècle

    CERN Document Server

    Mikeš, Jan; Grelon, André

    2016-01-01

    L'ouvrage retrace la naissance des formations d'ingénieurs électriciens, à partir de la fin du XIXe siècle, en Europe et sur le continent américain, en relation avec le développement de l'industrie électrique et l'organisation des réseaux d'électricité dans les différents États. Il rassemble les contributions de 28 historiens portant sur 15 pays.

  8. Dedicated to Prof. Dr.-Ing. Dr.techn. E.h. Jurjen Zierep on the occasion of his 80th birthday Transonic flows in narrow channels

    Institute of Scientific and Technical Information of China (English)

    A. Kluwick

    2009-01-01

    This article is the written version of a lecture given at the Festkolloquium on the occasion of Prof. Dr.-Ing.Dr.techn. E.h. Jurgen Zierep's 80th birthday held at the Universitat Karlsrube, 21 January 2009. It deals with laminar viscous inviscid interactions in transonic narrow channel flows. Special emphasis is placed on the internal structure of pseudo-shocks and properties of nozzle flows. Also, it is shown that the theory, first formulated for perfect gases, can easily be extended to the case of general single phase fluids.

  9. Finance computationnelle et gestion des risques ingénierie financière avec applications Excel (Visual Basic) et Matlab

    CERN Document Server

    Racicot, François-Éric

    2006-01-01

    Ce manuel propose un exposé rigoureux de la gestion des risques en finance. Les aspects théoriques de la question sont abordés par des démonstrations claires et des rappels élaborés des bases mathématiques de la finance computationnelle. Le texte est émaillé de nombreux programmes écrits en langages Visual Basic (Excel), Matlab et EViews qui prépareront l'étudiant à sa carrière de spécialiste en ingénierie financière.

  10. Central bank Financial Independence

    OpenAIRE

    J.Ramon Martinez-Resano

    2004-01-01

    Central bank independence is a multifaceted institutional design. The financial component has been seldom analysed. This paper intends to set a comprehensive conceptual background for central bank financial independence. Quite often central banks are modelled as robot like maximizers of some goal. This perspective neglects the fact that central bank functions are inevitably deployed on its balance sheet and have effects on its income statement. A financially independent central bank exhibits ...

  11. Production de savoir et dynamique pédagogique ingénieuse. Le cas particulier de « l’Ecole de Tours »

    Directory of Open Access Journals (Sweden)

    Catherine Guillaumin

    2012-04-01

    Full Text Available Depuis les années ‘80, les enseignants-chercheurs du département des sciences de l’éducation et de la formation de l’Université de Tours développent une pédagogie universitaire de formation par alternance comme voie différente pour apprendre et se former. « L’Ecole de Tours » est fondée sur le primat de l’expérience et celui de la production de savoir, renversant l’ordonnancement classique de la formation, mais convergeant vers l’abstraction avec les mêmes exigences de savoirs rigoureux conceptuels et méthodologiques. Elle est le produit complexe de l’ingenium lerbétien et du génie stratégique et pédagogique de Gaston Pineau. Cette contribution recense et explicite l’ingéniosité pédagogique qui structure transversalement ces dispositifs de formation associant, dans la complémentarité, les professionnels, dans et hors les murs de l’université, tandis qu’une veille réflexive et transformatrice, attentive aux changements sociétaux, oriente les ré-ingénieries successives.

  12. Sur quelles bases théoriques susciter un questionnement éthique en école d'ingénieurs ?

    Directory of Open Access Journals (Sweden)

    Quiquerez Guillaume

    2014-01-01

    Full Text Available Cette contribution analyse quelques questions préalables à une pédagogie entendant favoriser un questionnement éthique dans une école d'ingénieurs. Après avoir proposé une typologie d'une demande sociale adressée aux ingénieurs, sont discutées la position de Max Weber sur la neutralité axiologique, la stratégie d'Amartya Sen face à l'institutionnalisme transcendantal, et les analyses de Paul Ricœur sur le renouveau du concept de responsabilité. Nous en déduisons alors un environnement théorique permettant de mieux cerner les contours d'une éthique de la responsabilité rénovée et un questionnement devant permettre d'orienter la construction d'une réflexion pédagogique.

  13. 浅谈静脉留置针与疼痛的关系%Introduction to venous indwel ing needle's relationship with pain

    Institute of Scientific and Technical Information of China (English)

    孙炳坤

    2015-01-01

    Objective:Objective to explore the venous indwel ing needle puncture method of dif erent ef ects on pain.Methods:71 cases,aged 35-74 to compare pain between patients.The puncture point of view.Result:the success rate is closely related to the pain.Conclusion:Puncture a successful and and 45°to the skin into the indwel ing needle can reduce pain.%目的::探讨静脉留置针不同的穿刺方法对疼痛的影响。方法:对71例,年龄在35—74岁之间的患者进行疼痛比较。结果:穿刺的角度,成功率与疼痛密切相关。结论:穿刺一次成功及留置针与皮肤呈45°进针均可降低疼痛感。

  14. Décrire et comparer des formations d'ingénieurs interdisciplinaires : enjeux méthodologiques et épistémologiques

    Directory of Open Access Journals (Sweden)

    Godfroy Anne-Sophie

    2014-01-01

    La communication reviendra sur les résultats du projet HELENA et sur leur interprétation dans une perspective heuristique. Un objectif de cette étude était de permettre une première comparaison afin de mettre en lumière les caractéristiques des enseignements en école d'ingénieur et la complexité de leur organisation. Le projet a démontré l'efficacité des outils de mise en équivalence mis en place par le processus de Bologne. Il conviendrait dans un second temps de définir plus précisément les termes de la comparaison et de chercher des méthodologies comparatives plus élaborées de manière à mieux comprendre en quoi les sciences humaines et sociales préparent à la vie professionnelle ou rendent plus attractives des formations d'ingénieurs.

  15. Let Chin P’ ing Mei Study Shining Glory of Speculative Philosophy---On Zhou Juntao’ s Chin P’ ing Mei Study Series%让《金瓶梅》研究闪耀哲学思辨的光辉--读《周钧韬金瓶梅研究文集》

    Institute of Scientific and Technical Information of China (English)

    付善明

    2013-01-01

    Mr.Zhou Juntao is a famous scholar of Chin P ’ing Mei,and Zhou Juntao Jin Ping Mei Study Series is his com-prehensive expression of Chin P ’ ing Mei study .The prominent characteristics of Zhou Juntao ’ s study is the high level acces-sion,the text study specialty is “on the realism to the theory”,and his study shows a very strong philosophical overtones . Some of his views have great impact ,and his studies are of important contributions to Chin P ’ ing Me academic sectors .%周钧韬先生是一位著名的金学家,《周钧韬金瓶梅研究文集》是其《金瓶梅》研究集大成的作品。周钧韬《金瓶梅》研究的突出特点是高层次加入,文本研究特色是“就实论虚”,其金学研究呈现出很强的哲学思辨色彩。他的一些观点有较大影响,为《金瓶梅》研究做出了重要贡献。

  16. Banco Central de Costa Rica

    Directory of Open Access Journals (Sweden)

    Sauter, Franz

    1963-06-01

    Full Text Available This new building is intended to house the various services of the Central Bank of Costa Rica. It has a prestressed concrete structure, and consists of a basement parking space for 105 vehicles, and nine storeys, providing altogether a floor surface of 12,000 ms2. The building rests on a ground area of 40 by 60 ms, and the main structure occupies 22 by 45 ms. This Bank is located in a district of narrow streets, but its main side overlooks a green open space, which will improve its visibility and appearance. The building structure is made up of a framework of prestressed beams and columns. The beams have been concreted at the site, and the joists, which are also prestressed, are factory made. This framework, at each floor level, constitutes the basis of a continuous slab, which renders the total structure exceedingly stiff. The main continuous girders span 11.22 ms spaces, and vary in cross section. The prestressing reinforcements consist of 6 Loeba type cables. This is an original design by Dr. Leonhardt, in which the cables are placed on three horizontal layers, of parabolic outline. Each cable is made up of 12 x 5.4 mm wires, with a breaking stress of 180 kg/mm2 The tensioning stress was 108 kg/mm2, and the total prestress load is 29,700 kgs. The cables run in corrugated metal tubes, and these were kept in precise position with the aid of distance pieces.El nuevo edificio, destinado a agrupar los servicios del Banco Central de Costa Rica, está constituido por una estructura de hormigón pretensado. El inmueble dispone de un sótano, estacionamiento propio para 105 vehículos y nueve plantas, con una superficie total de 12.000 metros cuadrados. Se asienta sobre una base de 40x60 m, donde se levanta un núcleo central de 22x45 metros. Está situado en un barrio de calles estrechas, pero tiene su fachada, principal frente a una zona verde que le proporcionará mayor categoría y visibilidad. La estructura se compone de una retícula de vigas

  17. NIDDK Central Repository

    Data.gov (United States)

    U.S. Department of Health & Human Services — The NIDDK Central Repository stores biosamples, genetic and other data collected in designated NIDDK-funded clinical studies. The purpose of the NIDDK Central...

  18. Central Neuropathic Pain Syndromes.

    Science.gov (United States)

    Watson, James C; Sandroni, Paola

    2016-03-01

    Chronic pain is common in patients with neurologic complications of a central nervous system insult such as stroke. The pain is most commonly musculoskeletal or related to obligatory overuse of neurologically unaffected limbs. However, neuropathic pain can result directly from the central nervous system injury. Impaired sensory discrimination can make it challenging to differentiate central neuropathic pain from other pain types or spasticity. Central neuropathic pain may also begin months to years after the injury, further obscuring recognition of its association with a past neurologic injury. This review focuses on unique clinical features that help distinguish central neuropathic pain. The most common clinical central pain syndromes-central poststroke pain, multiple sclerosis-related pain, and spinal cord injury-related pain-are reviewed in detail. Recent progress in understanding of the pathogenesis of central neuropathic pain is reviewed, and pharmacological, surgical, and neuromodulatory treatments of this notoriously difficult to treat pain syndrome are discussed.

  19. Central venous catheter - flushing

    Science.gov (United States)

    ... during cancer treatment Bone marrow transplant - discharge Central venous catheter - dressing change Peripherally inserted central catheter - flushing Sterile technique Surgical wound care - open Review Date 9/22/2016 Updated by: ...

  20. L'art de l'ingénieur constructeur entrepeneur interventeur. Gran exposición en el centro Georges Pompidou de Paris

    OpenAIRE

    Fernández Ordóñez, José A.; Navarro Vera, José Ramón; Arenas de Pablo, Juan José

    1997-01-01

    RESUMEN. En el Centro Georges Pompidou de París, el próximo 24 de junio se inaugurará la exposición titulada "L´Art de l´Ingénieur", probablemente la más importante muestra realizada acerca de la ingeniería civil desde mediados del siglo XIX hasta finales del XX, siendo comisarios de la misma José A. Fernández Ordóñez, de Madrid, y Raymond Guidot y Alain Guiheux, de París. Entre las aportaciones más interesantes de esta exposición está la publicación de un Diccionario de vocablos relacionados...

  1. En quoi les TIC changent-elles les pratiques d'ingénierie pédagogique du professeur d'université ?

    OpenAIRE

    Josianne Basque

    2004-01-01

    [Français] Ce numéro spécial sur le thème L’ingénierie pédagogique à l’heure des TIC s’inscrit dans la suite d’un colloque portant sur ce même thème qui s’est tenu le 26 novembre 2004 à l’Université McGill, à Montréal. Ce colloque, organisé sous l’égide du Sous-comité des technologies de l’information et de la communication de la CREPUQ (Conférence des recteurs et des principaux des universités du Québec), a réuni près de 200 personnes : professeurs, professionnels des services pédagogiques d...

  2. Gérer l'interface entre ingénierie, didactique, pédagogie et dispositifs ouverts Interfacing open learning environments, didactics and pedagogy

    Directory of Open Access Journals (Sweden)

    Guy Achard-Bayle

    2003-06-01

    Full Text Available Nous proposons de croiser le regard du didacticien linguiste et celui du spécialiste de l'utilisation des TIC pour la formation et de l'ingénierie de formation, afin d'analyser des dispositifs expérimentaux "ouverts" que nous avons pu observer de près. Le premier est un dispositif à distance basé sur une pédagogie du projet, le second relève de l'autoformation guidée en centre de ressources. Dans les deux cas on relève le rôle pivot du centre de ressources et la disparition du groupe-classe. Quelques points importants pour une approche des dispositifs ouverts se dégagent, entre autres tutorat et suivi des apprenants, rapport au temps (temps perdu, temps retrouvé, choix des ressources supports des apprentissages (outils de référence et matériaux pédagogiques. Nous plaiderons pour une meilleure gestion de l'interface entre ingénierie, didactique, pédagogie et dispositifs ouverts par une remobilisation du didacticien autour de quelques axes se dégageant de nos observations.We acted as linguists interested in didactics and specialists in the use of ICT to analyze two language learning environments we had an opportunity to closely follow. Both can be labeled as open learning systems relying on self directed learning. We point out the importance of the self access learning centre where learners come and the disappearance of the traditional group. Several relevant elements are analyzed such as tutoring and coaching of learners, changes in the relationship to time (wasting and finding time, choosing appropriate materials (reference tools or teaching materials. We will argue in favor of a more deliberate implication of didactics so as to better approach open learning situations and self directed learning.

  3. Sedimentary environments in the south-western Barents Sea during the last deglaciation and the Holocene: a case study outside the Ingøydjupet trough

    Directory of Open Access Journals (Sweden)

    Mauro Pau

    2016-05-01

    Full Text Available A lithological and foraminiferal study of newly acquired sediment cores outside the Ingøydjupet (Ingøy Deep trough has been carried out to improve constraints on the last deglacial history in the south-western Barents Sea. Three lithofacies and three foraminiferal facies were identified. The lowermost lithological unit is a diamicton interpreted as glacial till. It contains a low-abundance, ecologically mixed foraminiferal assemblage, presumably resulting from glacial reworking. Above the diamicton, a layer of ice-rafted debris (IRD, likely associated with intensive iceberg production, marks the initial destabilization of the marine-based ice sheet. At this time, ca. 15.6–15.0 Ky B.P., opportunistic foraminiferal species Nonionellina labradorica and Stainforthia spp. reached peak abundance. During the south-western Barents Sea ice-margin retreat, presumably corresponding to the Bølling interstadial, a sequence of glaciomarine laminations was deposited conformably on the layer of IRD. Sedimentation rates were apparently high (estimated about 0.4 cm per year and the foraminiferal fauna was dominated by Elphidium spp. and Cassidulina reniforme, species common for glacier-proximal environments. A hiatus at the top of the deglacial unit is likely linked to the high bottom-current activity associated with a strengthened inflow of Atlantic water masses into the Barents Sea. The uppermost lithological unit is represented by the Holocene marine sandy mud. It contains a high-abundance, high-diversity foraminiferal fauna with common cassidulinids, Cibicides spp., Epistominella pusilla and planktic species.

  4. Disposable and Usable Pasts in Central European Cities

    Directory of Open Access Journals (Sweden)

    Agata Lisiak

    2009-12-01

    Full Text Available In Central European cities memories and material histories of socialist regimes remain particularly difficult to address and incorporate into the new democratic present. After 1989, city authorities in the region have chosen to emphasize some pasts and neglect others and, thus, (rewrite their own versions of (urban history and (reshape their (urban identities. In my paper I inquire into how post-1989 Central European urbanities are shaped by and communicated through various designations including signs and symbols on city streets, monuments, and build-ings. Predictably, many material remnants of the socialist regimes have been de-stroyed or hidden from the public eye - my interest lies not only in which various designations on buildings and which monuments had to go, but also in why and how they disappeared. I discuss the most popular methods of hiding and/or effac-ing the remnants of socialism that range from subtle (surrounding of communist landmarks with tall buildings through the obvious (renaming of streets, squares, metro stations; giving old communist buildings new names and functions to the irreversible and, thus, most controversial (the razing of socialist architecture and monuments. The disappearance of the material capital of the socialist past has been accompanied by intense commemoration practices verging on memorial ob-sessions. New monuments, plaques, street names, and museums appeared almost as quickly as the old "disposable" ones were forced out from the urban landscape. The complexity of an urban identity as communicated through city streets, mo-numents, and buildings not only invites, but necessitates an interdisciplinary ap-proach and, thus, my analysis includes elements from such diverse areas of know-ledge as aesthetics, architecture, communication studies, comparative cultural studies, economics, history, and political science.

  5. Ingéniérie actuarielle : les modèles de régression non linéaires comme solutions à divers problèmes actuariels/

    OpenAIRE

    Brouhns, Natacha

    2005-01-01

    Cette thèse est mue par la volonté de son auteur (et de son promoteur) de mettre en évidence combien le concept d'ingéniérie actuarielle est non seulement un concept actuel mais également porteur d'avenir pour l'actuariat. Dans ingéniérie, on entend ingénieur, soit un individu formé à l'application des sciences, dans le but de résoudre des problèmes technologiques concrets et complexes. Ces compétences, traditionnellement plutôt utilisées par l'industrie, sont ici mises au service ...

  6. Central Laboratories Services

    Data.gov (United States)

    Federal Laboratory Consortium — The TVA Central Laboratories Services is a comprehensive technical support center, offering you a complete range of scientific, engineering, and technical services....

  7. Central Pain Syndrome

    Science.gov (United States)

    ... or hands. Central pain syndrome often begins shortly after the causative injury or damage, but may be delayed by months or even years, especially if it is related to post-stroke pain. × Definition Central pain syndrome is a neurological ...

  8. Central centrifugal cicatricial alopecia

    Directory of Open Access Journals (Sweden)

    Collin Blattner

    2013-01-01

    Full Text Available Central centrifugal cicatricial alopecia is a common cause of progressive permanent apical alopecia. This unique form of alopecia includes entities previously know as "hot comb alopecia," "follicular degeneration syndrome," "pseudopelade" in African Americans and "central elliptical pseudopelade" in Caucasians. The etiology appears to be multifactorial and the condition occurs in all races.

  9. Optimal central bank transparency

    NARCIS (Netherlands)

    van der Cruijsen, C.A.B.; Eijffinger, S.C.W.; Hoogduin, L.

    2008-01-01

    Should central banks increase their degree of transparency any further? We show that there is likely to be an optimal intermediate degree of central bank transparency. Up to this optimum more transparency is desirable: it improves the quality of private sector inflation forecasts. But beyond the opt

  10. Optimal central bank transparency

    NARCIS (Netherlands)

    van der Cruijsen, C.A.B.; Eijffinger, S.C.W.; Hoogduin, L.H.

    2010-01-01

    Should central banks increase their degree of transparency any further? We show that there is likely to be an optimal intermediate degree of central bank transparency. Up to this optimum more transparency is desirable: it improves the quality of private sector inflation forecasts. But beyond the opt

  11. S.E.E.ing the Future: Science, Engineering and Education. Commentary from the Scientific Grassroots. A White Paper on the Issues and Need for Public Funding of Basic Science and Engineering Research.

    Science.gov (United States)

    Jemison, Mae C., Ed.

    This document reports on the results of an ad hoc workshop called "S.E.E.ing the Future: Science Engineering and Education" Held at Dartmouth College in November of 2000 and sponsored by Dartmouth, the National Science Foundation, the Dow Chemical Company, and Science Service of Washington, DC. This transdisciplinary conference was one of a series…

  12. Bernard Grall, Économie de forces et production d’utilités. L’émergence du calcul économique chez les ingénieurs des Ponts et Chaussées (1831-1891, manuscrit révisé et commenté par François Vatin, Rennes, Presses universitaires de Rennes, 2004, 28 euros.Jean-Pascal Simonin, François Vatin (dir., L’œuvre multiple de Jules Dupuit (1804-1866. Calcul d’ingénieur, analyse économique et pensée sociale, Angers, Presses universitaires d’Angers, 2002, 15,25 euros.

    Directory of Open Access Journals (Sweden)

    Pierre Crépel

    2005-09-01

    Full Text Available Jules Dupuit, dont on commémore le bicentenaire en 2004, est la figure centrale de ces deux ouvrages : comme personnage étudié en tant que tel sous de multiples facettes, dans le second ; aux côtés de nombre de ses collègues de l’École des ponts et chaussées, dans le premier. Dans l’un et l’autre cas, les auteurs se penchent sur les interactions entre les activités concrètes de l’ingénieur et la construction de ses théories économiques, leurs formalisations au XIXe siècle. Les liens entre méc...

  13. Velferð raflausnarbíla hjá Alcoa Fjarðaráli : innleiðing og ávinningur

    OpenAIRE

    Þórður Valdimarsson 1965

    2015-01-01

    Í þessu verkefni er leitast við að svara því hver er ávinningur af innleiðingu á velferð búnaðar fyrir raflausnarbíla Fjarðaáls og með hvaða hætti væri skynsam-legt að innleiða þessa aðferðafræði. Lögð var fyrir spurningakönnun sem starfs-fólk kerskála svaraði. Með því fengust mikilvæg gögn sem koma til með að móta hvernig verði staðið að innleiðingu á velferð búnaðar. Velferð búnaðar er þýðing Alcoa á autonomous maintenance. Í bók Iðntæknistofnunar TPM fyrir starfsfólk í iðnaði er íslensk þ...

  14. A Misuse of Bion's "Reverie-ing Mother": Another Weapon in the War against Women as Waged in the Consulting Room.

    Science.gov (United States)

    Lament, Claudia

    2015-01-01

    "The war against women" is a systemic process of discrimination that seeks to subjugate women. In this essay, I will critically examine a contemporary paper, published in a well-known psychoanalytic journal, that views the patient through the lens of Bion's "reverie-ing mother" concept. I argue that leaning upon any particular theory to explain an individual's complex psychological disturbance adheres to a reductionistic line of reasoning that falls prey to the genetic fallacy; interpreting psychological phenomena in this way becomes a myopically focused perch that narrows the clinician's range of vision in scanning the field for other features that influenced the patient's symptomatology and suffering. It defies what we know about the reorganizational potential of the developmental trajectory wherein early features undergo significant change over the course of growth. Within the context of the war against women, such a constrained perspective places the onus of responsibility upon the mother, making her the "whipping boy" for her child's difficulties. Within a blink of an eye, she turns into the embodiment of the trope of the "bad mother." The consequence of misusing a way of thinking about the early mother-child relationship has the unfortunate effect of promoting the war in our current zeitgeist.

  15. Viini noored arhitektid / Inge Laurik

    Index Scriptorium Estoniae

    Laurik, Inge

    2001-01-01

    21. augustist Pärnu Muuseumi Aidas Viini noori arhitekte tutvustav näitus "innere szene wien". Näha saab 47 Viini arhitektuuribüroo koostatud prospekte, olustikufotosid ateljeede töökeskkonnast, videoklippi.

  16. Linnaosa toetas kosjakontorit / Inge Rumessen

    Index Scriptorium Estoniae

    Rumessen, Inge

    2000-01-01

    Lasnamäe endine vanem Andrei Sorokolet eraldas ametisoleku viimasel päeval linnaosa reservfondist 20000 krooni laste kultuuriürituste korraldamiseks naisteklubis Valge Valss, mis kaasrentnike seas on teada kui intiimteenust pakkuv asutus

  17. "Groom"-ing the Students

    Science.gov (United States)

    Cunningham, Karen

    2010-01-01

    Art educators are aware that one way to inspire students is to introduce them to prominent artists. They all know that many students have preconceived notions that artists only become well-known after death, or that a life of art means a life of poverty. To open the students' eyes, the author always tries to include lessons about successful,…

  18. Editorial-27(2) (ING)

    OpenAIRE

    2013-01-01

    Editorial, Vol.27, N°2 (31 de Julio de 2013).En este número se da continuidad a los aportes en el área de Matemáticas. Los trabajos presentados refieren a la Enseñanza de las Matemáticas y Matemáticas Aplicadas. Editorial, Vol.27, N°2 (31 de Julio de 2013).En este número se da continuidad a los aportes en el área de Matemáticas. Los trabajos presentados refieren a la Enseñanza de las Matemáticas y Matemáticas Aplicadas.

  19. The central peak revisited

    Energy Technology Data Exchange (ETDEWEB)

    Shirane, G.

    1995-10-27

    The central peak in SrTiO{sub 3} was first observed by Riste and his collaborators in 1971. This was one of the key discoveries leading to an understanding of the dynamics of phase transitions. The most recent discovery of two length scales in SrTiO{sub 3} motivated a reinvestigation of the soft phonon and associated central peak by neutron scattering. These recent experiments shed new light on the nature of the central peak. It is now well established to be strongly sample dependent and it originates from defects in bulk crystals.

  20. Imaging central pain syndromes.

    Science.gov (United States)

    Veldhuijzen, Dieuwke S; Greenspan, Joel D; Kim, Jong H; Coghill, Robert C; Treede, Rolf-Detlef; Ohara, Shinji; Lenz, Frederick A

    2007-06-01

    Anatomic, functional, and neurochemical imaging studies have provided new investigative tools in the study of central pain. High-resolution imaging studies allow for precise determination of lesion location, whereas functional neuroimaging studies measure pathophysiologic consequences of injury to the central nervous system. Additionally, magnetic resonance spectroscopy evaluates lesion-induced neurochemical changes in specific brain regions that may be related to central pain. The small number of studies to date precludes definitive conclusions, but the recent findings provide information that either supports or refutes current hypotheses and can serve to generate new ideas.

  1. Central nervous system resuscitation

    DEFF Research Database (Denmark)

    McIntosh, T K; Garde, E; Saatman, K E;

    1997-01-01

    Traumatic injury to the central nervous system induces delayed neuronal death, which may be mediated by acute and chronic neurochemical changes. Experimental identification of these injury mechanisms and elucidation of the neurochemical cascade following trauma may provide enhanced opportunities ...

  2. Central Asian Republic Info

    Data.gov (United States)

    US Agency for International Development — CAR Info is designed and managed by the Central Asian Republic Mission to fill in the knowledge and reporting gaps in existing agency systems for that Mission. It...

  3. Central nervous system

    Science.gov (United States)

    The central nervous system is composed of the brain and spinal cord. Your brain and spinal cord serve as the main "processing center" for your entire nervous system. They control all the workings of your body.

  4. Central nervous system resuscitation

    DEFF Research Database (Denmark)

    McIntosh, T K; Garde, E; Saatman, K E

    1997-01-01

    Traumatic injury to the central nervous system induces delayed neuronal death, which may be mediated by acute and chronic neurochemical changes. Experimental identification of these injury mechanisms and elucidation of the neurochemical cascade following trauma may provide enhanced opportunities...

  5. "Central Station" Londonis

    Index Scriptorium Estoniae

    2000-01-01

    Londoni galeriis Milch seitsme läti, leedu ja eesti kunstniku projekt "Central Station". Kuraatorid Lisa Panting, Sally Tallant. Eestist osalevad Hanno Soans (Catarina Campinoga koostöös valminud video), Kiwa, Kai Kaljo

  6. Central Station Design Options

    DEFF Research Database (Denmark)

    2011-01-01

    The purpose of EDISON Work Package 4.1 is the evaluation of possible Central (charging) Stations design options for making possible the public charging of Electric Vehicles (EVs). A number of scenarios for EVs are assessed, with special emphasis on the options of Fast Charging and Battery Swapping....... The work identifies the architecture, sizing and siting of prospective Central Stations in Denmark, which can be located at shopping centers, large car parking lots or gas stations. Central Stations are planned to be integrated in the Danish distribution grid. The Danish island of Bornholm, where a high.......g. due to vandalism, the charge supply circuit is disconnected. More electrical vehicles on the market are capable today of quick charging up to 50 kW power level. The feasibility of Central Stations with fast charging/swapping option, their capacity, design, costs and grid impact, as well as battery...

  7. Gangs in Central America

    Science.gov (United States)

    2008-10-17

    Citizen Security held in July 2008 indicated that Guatemala now has the second highest murder rate in Central America (roughly 45 per 100,000 people...training regional security forces.48 In recent years, the U.S. Southern Command has taken a leading role in discussing the problem of citizen security in...the results CRS-19 51 “Memo: The Merida Initiative and Citizen Security in Mexico and Central America,” Washington Office on Latin America, March 2008

  8. Outsourcing central banking

    DEFF Research Database (Denmark)

    Khoury, Sarkis Joseph; Wihlborg, Clas

    2005-01-01

    The literature on Currency Boards (CB) stops at the water edge in terms of dealing with the totality of the functions of a central bank. Monetary policy, and banking supervisioncan be "outsourced" in an open economy with substantial foreign direct investment (FDI)in the banking sector if political...... the feasibility of, and constraints on, outsourcing of central bank functions. A brief discussion of the Argentinian experience is used for contrast.Key words: Currency Board, Foreign Banks, Supervision, Regional Integration,outsourcing....

  9. For patients with age -related hearing loss of hearing aid fit ing method is analyzed%对于老年性听力损失患者助听器的验配方法进行分析

    Institute of Scientific and Technical Information of China (English)

    朱美林

    2014-01-01

    objective:focus for senile patients with hearing loss of hearing aid fit ing method and ef ect.Methods:to select the research object is early January to the end of December 2013,2012 during accept hearing -aid with 60 cases of senile patients with hearing loss,al patients were accepted hearing -aid,and strengthen the rehabilitation training.Results:the fit ing ef ect for only 1 case with poor fit ing ef ect for a total of 9 cases,good fit ing ef ect for a total of 50 cases,was as high as 98.33%.Conclusion:the light of the specific conditions of the patients with hearing loss,for patients to choose the appropriate hearing AIDS fit ing,and strengthen the rehabilitation training,to improve success rate of hearing aid fit ing.%目的:重点探索老年性听力损失患者助听器的验配方法及效果。方法:选取的研究对象是2012年1月初至2013年12月底期间接受助听器验配的60例老年性听力损失患者,所有患者均接受助听器验配,并加强康复训练。结果:验配效果为差的仅有1例,验配效果为良的总共有9例,验配效果为优的总共有50例,优良率高达98.33%。结论:结合听力损失患者的具体情况,为患者选择合适的助听器进行验配,并加强康复训练,有利于提高助听器验配成功率。

  10. The Visual Expression of Multimedia in Fine Arts Teach-ing%美术教学中多媒体的视觉表达

    Institute of Scientific and Technical Information of China (English)

    欧阳晓川

    2013-01-01

    This paper mainly introduces the visual expression of multimedia in normal college fine arts teaching and discusses how to give full play to the role of multimedia in fine arts teach-ing. By integrating multimedia technology and fine arts teaching, the former can serve for the later, and make fine arts more color-ful and total change the idea od fine arts teaching in our mind.%  本文主要是针对于大学师范类美术教学过程中,多媒体的视觉表达在高等教育的知识传授上得到了前所未有的发展和利用。为了更好地利用多媒体技术在美术教学过程中的作用,我们怎么样更好地发挥多媒体的视觉表达,是一个值得探讨的问题。多媒体的视觉表达,本是一个图形和技术相结合的概念,把两者有机地给合在一起,我们就能充分地利用多媒体来为自己的教学服务。当图形技术被转化为银幕形象而表达出来的时候,这种教学过程比单一的美术教学丰富了许多,并且能够彻底改变我们在美术教学中的观念。

  11. Redescription of some Spauligodon spp. and Parapharyngodon spp., and of skrjabinodon mabuyae (Sandground, 1936) inglis, 1968 (Pharyngodonidae: Oxyuroidea) from insectivorous South African lizards.

    Science.gov (United States)

    Hering-Hagenbeck, S F B N; Petter, A J; Boomker, J

    2002-03-01

    As part of a study on the helminth parasites of South African lizards several species of saurians were collected from localities in the North West Province, the Northern Province, Mpumalanga Province and Gauteng Province. Spauligodon blydeensis (Hering-Hagenbeck, 2001) from the Cape thick-toed gecko, Pachydactylus capensis, Spauligodon molpoensis (Hering-Hagenbeck, 2001) from Wahlberg's velvet gecko, Homopholis wahibergii, Parapharyngodon margaritiferi, Hering-Hagenbeck, 2001 from the skink, Mabuya margaritifer, Parapharyngodon gerrhosauri, Hering-Hagenbeck, 2001 from the plated lizard, Gerrhosaurus flavigularis and Skrjabinodon mabuyae (Sandground, 1936) Inglis, 1968 from the skinks Mabuya punctatissima, Mabuya spilogaster and Mabuya varia are redescribed. The different Spauligodon spp. in the subcontnent may be separated on the presence or absence of spicules in the males, the presence or absence of spines on the tail of both the males and females, as well as on the size and shape of the eggs, and the configuration of the polar caps. The Parapharyngodon spp. are distinguished mainly by the morphological characters of the males, such as the width of the caudal alae and the size of the pre- and adanal papillae. Female Parapharyngodon spp. closely resemble each other and some could not be identified to the species level since males were absent. Spinose larvae, together with adult Parapharyngodon spp. were recovered from Mabuya margaritifer. All Parapharyngodon spp. larvae described to date are spinose and since the larvae in this study were collected together with adult Parapharyngodon spp., we consider them to belong to the same genus. Skrjabinodon mabuyae differs from the closely related Skrjabinodon mabuiensis in the presence of a spicule in the male and lateral alae in the female. The former nematode is described for the first time from skinks in South Africa.

  12. Estudos sôbre a conservação de sementes. IX- Ingá Storage of Inga edulis seeds

    Directory of Open Access Journals (Sweden)

    Oswaldo Bacchi

    1961-01-01

    Full Text Available Dada sua extrema sensibilidade à desidratação, a semente de ingá (Inga edulis Mart. tem, em condições normais de armazenamento, uma longevidade bastante curta. Mesmo quando conservada dentro do próprio fruto, sua capacidade germinativa já se apresenta com evidentes sinais de enfraquecimento após 14 dias. De acôrdo com os resultados ora apresentados, o fator umidade constitui, realmente, o principal responsável pela maior ou menor longevidade da semente. Em todos os ensaios realizados, a perda de vitalidade se iniciou quando o teor de umidade das sementes se encontrava ao redor de 35%. A influência da temperatura foi apenas indireta, aumentando ou diminuindo a rapidez de desidratação das sementes. Embora mantendo seu teor inicial de umidade, as sementes conservadas em recipiente hermèticamente fechado perderam totalmente sua vitalidade em apenas 14 dias; isto se deu, provàvelmente, em conseqüência do acúmulo de gás carbônico proveniente da respiração da semente.Like other seeds of various economic crops, those of Inga edulis lose their vitality in a few days when exposed to the air. Storage of these short-lived seeds under different conditions of moisture content, temperature, and carbon dioxide accumulation has given the following information: 1. Seeds lose their viability when the water content is reduced to 35% or less. 2. Temperature seems not to be effective unless on the rale to which this critical point dessication is attained. 3. The rapid loss of vitality of seeds kept in airtight containers is probably due to the carbon dioxide accumulation. Here also the temperature seems to act indirectly, modifyng the rate of respiration of the seeds.

  13. CENTRAL PLATEAU REMEDIATION

    Energy Technology Data Exchange (ETDEWEB)

    ROMINE, L.D.

    2006-02-01

    A systematic approach to closure planning is being implemented at the Hanford Site's Central Plateau to help achieve the goal of closure by the year 2035. The overall objective of Central Plateau remediation is to protect human health and the environment from the significant quantity of contaminated material that resulted from decades of plutonium production in support of the nation's defense. This goal will be achieved either by removing contaminants or placing the residual contaminated materials in a secure configuration that minimizes further migration to the groundwater and reduces the potential for inadvertent intrusion into contaminated sites. The approach to Central Plateau cleanup used three key concepts--closure zones, closure elements, and closure process steps--to create an organized picture of actions required to complete remediation. These actions were merged with logic ties, constraints, and required resources to produce an integrated time-phased schedule and cost profile for Central Plateau closure. Programmatic risks associated with implementation of Central Plateau closure were identified and analyzed. Actions to mitigate the most significant risks are underway while high priority remediation projects continue to make progress.

  14. Complete genome sequence of Peptoniphilus sp. strain ING2-D1G isolated from a mesophilic lab-scale completely stirred tank reactor utilizing maize silage in co-digestion with pig and cattle manure for biomethanation.

    Science.gov (United States)

    Tomazetto, Geizecler; Hahnke, Sarah; Maus, Irena; Wibberg, Daniel; Pühler, Alfred; Schlüter, Andreas; Klocke, Michael

    2014-12-20

    The bacterium Peptoniphilus sp. strain ING2-D1G (DSM 28672), a mesophilic and obligate anaerobic bacterium belonging to the order Clostridiales was isolated from a biogas-producing lab-scale completely stirred tank reactor (CSTR) optimized for anaerobic digestion of maize silage in co-fermentation with pig and cattle manure. In this study, the whole genome sequence of Peptoniphilus sp. strain ING2-D1G, a new isolate potentially involved in protein breakdown and acidogenesis during biomass degradation, is reported. The chromosome of this strain is 1.6Mb in size and encodes genes predicted to be involved in the production of acetate, lactate and butyrate specifying the acidogenic metabolism of the isolate.

  15. The Naive Central Banker

    Directory of Open Access Journals (Sweden)

    Marcelo de Carvalho Griebeler

    2015-09-01

    Full Text Available There has been in some countries a trend of assigning other functions to central banks besides price stability. The most suggested function to be added to monetary authority’s obligations is to pursue economic growth or full employment. In this paper we characterize the behavior and analyse the optimal monetary policy of, what we call, a naive central banker. We describe the naive behavior as one that does face the inflation-unemployment trade-off, but it tries to minimize both variables simultaneously. Our findings, both under discretion and commitment, indicate that the naive central banker delivers lower expected inflation and inflation variance than the benchmark behavior whenever the economy is rigid enough. However, the degree of conservativeness also affects this result, such that the less conservative the naive policymaker, the more rigidity is necessary.

  16. SOCRATES Invades Central Europe

    Directory of Open Access Journals (Sweden)

    Joseph Slowinski

    1998-04-01

    Full Text Available The objective of this article is to explore the current reality faced by higher education students in Central and Eastern Europe and to draw out the implications of this current reality for policy makers in the future. In the article, I explore the influence of transnational corporations' training programs on education as it currently pertains to Central and Eastern European higher education and employment. In addition, multinational corporate entities exercise influence on European Union policy through the role of lobby organizations and activities. I explore the influence of these practices on education with an emphasis on the emerging importance of Western language skills. In addition, I focus on the European Union and its efforts to expand into Central and Eastern Europe in order to provide a focal point for analysis.

  17. Central Bank independence

    Directory of Open Access Journals (Sweden)

    Vasile DEDU

    2012-08-01

    Full Text Available In this paper we present the key aspects regarding central bank’s independence. Most economists consider that the factor which positively influences the efficiency of monetary policy measures is the high independence of the central bank. We determined that the National Bank of Romania (NBR has a high degree of independence. NBR has both goal and instrument independence. We also consider that the hike of NBR’s independence played an important role in the significant disinflation process, as headline inflation dropped inside the targeted band of 3% ± 1 percentage point recently.

  18. Several Centuries of Centrality

    OpenAIRE

    Roth, Dana L.

    2015-01-01

    As Carolyn Bertozzi mentioned in her inaugural editorial, the relationship of “Central Science” to “Chemistry” became popularized over 40 years ago with the publication of the first edition of Brown and LeMay’s Chemistry: The Central Science, now in its 13th edition. Yet as late as 2003, Prof. Sason Shaik at The Hebrew University claimed “popularization of chemistry remains scant.” He goes on to share [his] “own experience of popularizing chemistry by delivering the following universal messag...

  19. Glueballs A central mystery

    CERN Document Server

    Close, Francis Edwin

    2000-01-01

    Glueball candidates and qqbar mesons have been found to be produced with different momentum and angular dependences in the central region of pp collisions. This talk illustrates this phenomenon and explains the phi and t dependences of mesons with JPC = 0++,0-+, 1++, 2++ and 2-+. For production of 0++ and 2++ mesons the analysis reveals a systematic behaviour in the data that appears to distinguish between qqbar and non-qqbar or glueball candidates. An explanation is given for the absence of 0-+ glueball candidates in central production at present energies and the opportunity for their discovery at RHIC is noted.

  20. Análisis del error en la traducción automática: algunos ejemplos de las formas "-ing" del inglés al español

    Directory of Open Access Journals (Sweden)

    María I. Diéguez M.

    1998-09-01

    Full Text Available En el presente artículo se expondrá un estudio contrastivo de las formas "-ing" presentes en textos originales en inglés y sus respectivas traducciones al español realizadas con un programa de traducción automática (TA. Para ello se utilizaron como corpus de análisis dos textos originales en inglés, uno del área de ciencias sociales (economía y el otro de las ciencias exactas (minería. A través del análisis de los errores y aciertos de las traducciones realizadas mediante el programa de TA se pretende en último término extraer conclusiones prácticas para la enseñanza de la traducción técnico-científica. (A contrastive study of "-ing" forms in English and Spanish is presented. For such analysis, two original English texts and their respective Spanish machine translations (MT were used. One original text has been taken from the social sciences (economy and the other, from the technical-scientific field (mining. By comparing the machine translations of the "-ing" forms present in the original texts, conclusions may be drawn regarding the teaching of professional translation.

  1. Problems and Coping Strategies of College English Writ-ing%大学英语写作中存在的问题及应对策略

    Institute of Scientific and Technical Information of China (English)

    熊婧竹

    2014-01-01

    English writing training is an effective way to develop students' thinking and expression ability, also it is a standard to measure the effect of English teaching. The teaching of writing has become an indispensable part of English teaching in the uni-versity, however, it is the weak point of university English teach-ing. Due to the limited English teaching time, teachers need time to cope with university English level test, so they pay less atten-tion on English writing teaching. Aiming at these problems, teachers should combine theory with the reality of students, im-prove teaching methods, lay emphasis on vocabulary accumula-tion, expand English reading, cultivate students' writing skills, meanwhile improving the composition assessment methods,to im-prove the students' English writing ability.%英语写作能力训练是发展学生思维能力和表达能力的有效途径,也是衡量英语教学效果的标准之一。写作教学已经成为大学英语教学中不可或缺的重要组成部分,然而却是大学英语教学中的薄弱环节。由于英语教学的学时有限,以及依然严重的应付四、六级考试的应试写作教学,缺乏系统的写作训练,学生的基本写作能力得不到培养,学生的写作水平提高缓慢。针对这些问题,教师应结合学生的实际,改进教学方法,注重词汇积累,扩大学生的英语阅读量,培养学生的写作技能,同时改进作文评改方法,以提高学生的英语写作能力。

  2. PL3 Amidase, a Tailor-made Lysin Constructed by Domain Shuffling with Potent Killing Activity against Pneumococci and Related Species.

    Science.gov (United States)

    Blázquez, Blas; Fresco-Taboada, Alba; Iglesias-Bexiga, Manuel; Menéndez, Margarita; García, Pedro

    2016-01-01

    that the structure/function-based domain shuffling approach is a successful method to construct tailor-made endolysins with higher bactericidal activities than their parental enzymes.

  3. Retiring the central executive.

    Science.gov (United States)

    Logie, Robert H

    2016-10-01

    Reasoning, problem solving, comprehension, learning and retrieval, inhibition, switching, updating, or multitasking are often referred to as higher cognition, thought to require control processes or the use of a central executive. However, the concept of an executive controller begs the question of what is controlling the controller and so on, leading to an infinite hierarchy of executives or "homunculi". In what is now a QJEP citation classic, Baddeley [Baddeley, A. D. (1996). Exploring the central executive. Quarterly Journal of Experimental Psychology, 49A, 5-28] referred to the concept of a central executive in cognition as a "conceptual ragbag" that acted as a placeholder umbrella term for aspects of cognition that are complex, were poorly understood at the time, and most likely involve several different cognitive functions working in concert. He suggested that with systematic empirical research, advances in understanding might progress sufficiently to allow the executive concept to be "sacked". This article offers an overview of the 1996 article and of some subsequent systematic research and argues that after two decades of research, there is sufficient advance in understanding to suggest that executive control might arise from the interaction among multiple different functions in cognition that use different, but overlapping, brain networks. The article concludes that the central executive concept might now be offered a dignified retirement.

  4. Central Nervous System Tuberculosis

    OpenAIRE

    Bano, Shahina; Chaudhary, Vikas; Yadav, Sachchidanand

    2012-01-01

    Central nervous system tuberculosis is a rare presentation of active tuberculosis and accounts for about 1% of cases (1). The three clinical categories include meningitis, intracranial tuberculomas, and spinal tuberculous arachnoiditis. We report a case of a young man who presented with active pulmonary tuberculosis in addition to tuberculous meningitis and the presence of numerous intracranial tuberculomas.

  5. Central venous line - infants

    Science.gov (United States)

    A central venous line (CVL) is a long, soft, plastic tube that is put into a large vein in the chest. WHY IS A CVL USED? A CVL is often put in when a baby cannot get a ... (MCC). A CVL can be used to give nutrients or medicines to a ...

  6. CMS Central Hadron Calorimeter

    OpenAIRE

    Budd, Howard S.

    2001-01-01

    We present a description of the CMS central hadron calorimeter. We describe the production of the 1996 CMS hadron testbeam module. We show the results of the quality control tests of the testbeam module. We present some results of the 1995 CMS hadron testbeam.

  7. Ecodesign in Central America

    NARCIS (Netherlands)

    Crul, M.R.M.

    2003-01-01

    This PhD thesis describes and analyses the change process started by the Ecodesign project in Central America, executed between 1998 and 2002. The project started using the concept and praxis developed in Europe. Nine ecodesign projects were performed in industry, and ecodesign was introduced to cou

  8. Central nervous system tuberculosis.

    Science.gov (United States)

    Torres, Carlos; Riascos, Roy; Figueroa, Ramon; Gupta, Rakesh K

    2014-06-01

    Tuberculosis (TB) has shown a resurgence in nonendemic populations in recent years and accounts for 8 million deaths annually in the world. Central nervous system involvement is one of the most serious forms of this infection, acting as a prominent cause of morbidity and mortality in developing countries. The rising number of cases in developed countries is mostly attributed to factors such as the pandemic of acquired immunodeficiency syndrome and increased migration in a globalized world. Mycobacterium TB is responsible for almost all cases of tubercular infection in the central nervous system. It can manifest in a variety of forms as tuberculous meningitis, tuberculoma, and tubercular abscess. Spinal infection may result in spondylitis, arachnoiditis, and/or focal intramedullary tuberculomas. Timely diagnosis of central nervous system TB is paramount for the early institution of appropriate therapy, because delayed treatment is associated with severe morbidity and mortality. It is therefore important that physicians and radiologists understand the characteristic patterns, distribution, and imaging manifestations of TB in the central nervous system. Magnetic resonance imaging is considered the imaging modality of choice for the study of patients with suspected TB. Advanced imaging techniques including magnetic resonance perfusion and diffusion tensor imaging may be of value in the objective assessment of therapy and to guide the physician in the modulation of therapy in these patients.

  9. Central Dogma Goes Digital.

    Science.gov (United States)

    Lin, Yihan; Elowitz, Michael B

    2016-03-17

    In this issue of Molecular Cell, Tay and colleagues (Albayrak et al., 2016) describe a new technique to digitally quantify the numbers of protein and mRNA in the same mammalian cell, providing a new way to look at the central dogma of molecular biology.

  10. Multicultural Central Asia.

    Science.gov (United States)

    Boyle, Eric D.

    This article addresses the multicultural aspect of Central Asia in response to the discussion on diversity in U.S. classrooms. Many areas of the world are more diverse than the U.S., and these areas experience successes and failures with many of the same issues the U.S. is currently struggling with. Comparing the U.S. diversity debate with similar…

  11. Channeling the Central Dogma.

    Science.gov (United States)

    Calabrese, Ronald L

    2014-05-21

    How do neurons and networks achieve their characteristic electrical activity, regulate this activity homeostatically, and yet show population variability in expression? In this issue of Neuron, O'Leary et al. (2014) address some of these thorny questions in this theoretical analysis that starts with the Central Dogma.

  12. Company activities - central region

    Energy Technology Data Exchange (ETDEWEB)

    Ayling, G.

    2007-06-15

    The first section of the article gives an overview of exploration and new developments in the field of gold, nickel, diamond and opal mining in central Queensland. The second part looks at coal, coal seam gas and petroleum exploration and development projects in the area. 1 fig.

  13. Testing for central symmetry

    NARCIS (Netherlands)

    Einmahl, John; Gan, Zhuojiong

    2016-01-01

    Omnibus tests for central symmetry of a bivariate probability distribution are proposed. The test statistics compare empirical measures of opposite regions. Under rather weak conditions, we establish the asymptotic distribution of the test statistics under the null hypothesis; it follows that they a

  14. Central areolar choroidal dystrophy.

    NARCIS (Netherlands)

    Boon, C.J.F.; Klevering, B.J.; Cremers, F.P.M.; Zonneveld-Vrieling, M.N.; Theelen, T.; Hollander, A.I. den; Hoyng, C.B.

    2009-01-01

    OBJECTIVE: To describe the clinical characteristics, follow-up data and molecular genetic background in a large group of patients with central areolar choroidal dystrophy (CACD). DESIGN: Retrospective case series study. PARTICIPANTS: One hundred three patients with CACD from the Netherlands. METHODS

  15. Põlvkonnad baltisaksa ajalookirjutuses aastail 1919-2009 / Gert von Pistohlkors ; inglis- ja saksakeelsest käsikirjast tõlkinud Jaan Undusk

    Index Scriptorium Estoniae

    Pistohlkors, Gert von 1935-

    2010-01-01

    Baltisaksa ajaloolastest, kes avaldasid oma töid Baltimaade ajaloost ajavahemikul 1919-2009. Artikkel põhineb 4. detsembril 2009. aastal Södertörni Ülikoolis peetud konverentsil "East and central European history writing in exile - international dissemination of knowledge"

  16. Min(d)ing the land: The relationship between artisanal and small-scale mining and surface land arrangements in the southern Philippines, eastern DRC and Liberia

    NARCIS (Netherlands)

    Verbrugge, B.L.P.; Cuvelier, J.; Bockstael, S. van

    2015-01-01

    This article examines the relationship between artisanal and small-scale mining (ASM) and surface land tenure arrangements, through a comparison of mining areas in the southern Philippines, the eastern DRC and Liberia. In all three cases, ASM takes place in peripheral regions outside central state c

  17. Induced, endogenous and exogenous centrality

    OpenAIRE

    Everett, Martin G.; Stephen P. Borgatti

    2010-01-01

    Centrality measures are based upon the structural position an actor has within the network. Induced centrality, sometimes called vitality measures, take graph invariants as an overall measure and derive vertex level measures by deleting individual nodes or edges and examining the overall change. By taking the sum of standard centrality measures as the graph invariant we can obtain measures which examine how much centrality an individual node contributes to the centrality of the other nodes in...

  18. Do Central Banks Need Capital?

    OpenAIRE

    Peter Stella

    1997-01-01

    Central banks may operate perfectly well without capital as conventionally defined. A large negative net worth, however, is likely to compromise central bank independence and interfere with its ability to attain policy objectives. If society values an independent central bank capable of effectively implementing monetary policy, recapitalization may become essential. Proper accounting practice in determining central bank profit or loss and rules governing the transfer of the central bank’s ope...

  19. A Study of the Central Auditory Function in Stutters by Masking Level Difference and Synthetic Sentence Identification Tests

    Directory of Open Access Journals (Sweden)

    Afsaneh Rajab

    2007-06-01

    Full Text Available Background and Aim: There are evidences that indicate a relationship between auditory processing disor¬ders and stuttering,¬ and any disorder in the central auditory function can be at least one of the underly¬ing causes of stuttering. Even though, using the most state of the art radiographic technologies, i.e. MRI, no definitive answer has been given in relative to this question. In this research, using Mask-ing Level Difference (MLD and Synthetic Sentence Identification (SSI tests, the central auditory func¬tion of stutters and normal group was evaluated.Materials and Methods: In this study was analytic cross-sectional, fifteen male patients with stutter-ing and 15 male normal cases with the age range from 16 to 40 years (average age 26.78 year were evalu¬ated. SSI-ICM, SSI-CCM and MLD tests were performed. The results were compared in both groups.Results: Although stutterers mean MLD was less than that of normal group, the different was not signifi¬cant between stutters and normal group in SSI test in right ear at negative MCRs. There was a signifi¬cant difference in ICM state, but in CCM state, there was no significant difference between the aver¬age score of two groups in various MCRs.Conclusion: The findings of this research is compatible with those of similar researches about the SSI test and the pattern of results, probably indicates a partial dysfunction of brainstem in some of the stutters.

  20. “deepen[ing] the power and horror of the original”: Caroline Clive’s Paul Ferroll as Descendant of Jane Eyre “deepen[ing] the power and horror of the original”: Paul Ferroll de Caroline Clive héritier de Jane Eyre

    Directory of Open Access Journals (Sweden)

    Adrienne E. Gavin

    2009-07-01

    Full Text Available Lorsque le roman de Caroline Clive, Paul Ferroll, fut publié en juillet 1855, la critique ne tarda pas à faire le lien avec Jane Eyre (1847, de Charlotte Brontë. Les premiers à se pencher sur ce roman jugèrent les deux textes dans des termes similaires, les considérant comme choquants, originaux, puissants et audacieux. En renversant les attentes victoriennes dans le champ de la fiction et en transgressant les « règles » imposées aux femmes-écrivains, ces livres étaient, pensait-on, porteurs de qualités « masculines » tour à tour louées et dénigrées. Paul Ferroll fut donc vu comme un héritier de Jane Eyre qui « accentuait la puissance et l’horreur de l’original » (« deepen[ing] the power and horror of the original ». Cette accentuation est particulièrement prégnante dans le choix de Clive comme protagoniste criminel ; à l’instar de Rochester, ce dernier est un héros byronien qui cache un lourd secret au sujet de sa première épouse.

  1. Central simple Poisson algebras

    Institute of Scientific and Technical Information of China (English)

    SU Yucai; XU Xiaoping

    2004-01-01

    Poisson algebras are fundamental algebraic structures in physics and symplectic geometry. However, the structure theory of Poisson algebras has not been well developed. In this paper, we determine the structure of the central simple Poisson algebras related to locally finite derivations, over an algebraically closed field of characteristic zero.The Lie algebra structures of these Poisson algebras are in general not finitely-graded.

  2. Central corneal abscess.

    Science.gov (United States)

    van Bijsterveld, O P

    1976-05-01

    Central corneal abscess developed in the experimental animal after inoculation of biologically active staphylococcal strains in a paracentral epithelial lesion of the cornea. These abscesses did not ulcerate, developed only with high inocula, occurred more frequently in immunized rabbits. A serpiginous type of ulceration did not develop at the site of the initial epithelial lesion nor at any other place in the cornea. Histologically, the lesions consisted of densely packed polymorphonuclear leukocytes between the corneal lamellae.

  3. FNAL central email systems

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jack; Lilianstrom, Al; Pasetes, Ray; Hill, Kevin; /Fermilab

    2004-10-01

    The FNAL Email System is the primary point of entry for email destined for an employee or user at Fermilab. This centrally supported system is designed for reliability and availability. It uses multiple layers of protection to help ensure that: (1) SPAM messages are tagged properly; (2) All mail is inspected for viruses; and (3) Valid mail gets delivered. This system employs numerous redundant subsystems to accomplish these tasks.

  4. Centrality Measures in Networks

    CERN Document Server

    Bloch, Francis; Tebaldi, Pietro

    2016-01-01

    We show that although the prominent centrality measures in network analysis make use of different information about nodes' positions, they all process that information in an identical way: they all spring from a common family that are characterized by the same simple axioms. In particular, they are all based on a monotonic and additively separable treatment of a statistic that captures a node's position in the network.

  5. Distributed Assessment of Network Centrality

    CERN Document Server

    Wehmuth, Klaus

    2011-01-01

    We propose a method for the Distributed Assessment of Network CEntrality (DANCE) in complex networks. DANCE attributes to each node a volume-based centrality computed using only localized information, thus not requiring knowledge of the full network topology. We show DANCE is simple, yet efficient, in assessing node centrality in a distributed way. Our proposal also provides a way for locating the most central nodes, again using only the localized information at each node. We also show that the node rankings based on DANCE's centrality and the traditional closeness centrality correlate very well. This is quite useful given the vast potential applicability of closeness centrality, which is however limited by its high computational costs. We experimentally evaluate DANCE against a state-of-the-art proposal to distributively assess network centrality. Results attest that DANCE achieves similar effectiveness in assessing network centrality, but with a significant reduction in the associated costs for practical ap...

  6. Central core disease

    Directory of Open Access Journals (Sweden)

    Jungbluth Heinz

    2007-05-01

    Full Text Available Abstract Central core disease (CCD is an inherited neuromuscular disorder characterised by central cores on muscle biopsy and clinical features of a congenital myopathy. Prevalence is unknown but the condition is probably more common than other congenital myopathies. CCD typically presents in infancy with hypotonia and motor developmental delay and is characterized by predominantly proximal weakness pronounced in the hip girdle; orthopaedic complications are common and malignant hyperthermia susceptibility (MHS is a frequent complication. CCD and MHS are allelic conditions both due to (predominantly dominant mutations in the skeletal muscle ryanodine receptor (RYR1 gene, encoding the principal skeletal muscle sarcoplasmic reticulum calcium release channel (RyR1. Altered excitability and/or changes in calcium homeostasis within muscle cells due to mutation-induced conformational changes of the RyR protein are considered the main pathogenetic mechanism(s. The diagnosis of CCD is based on the presence of suggestive clinical features and central cores on muscle biopsy; muscle MRI may show a characteristic pattern of selective muscle involvement and aid the diagnosis in cases with equivocal histopathological findings. Mutational analysis of the RYR1 gene may provide genetic confirmation of the diagnosis. Management is mainly supportive and has to anticipate susceptibility to potentially life-threatening reactions to general anaesthesia. Further evaluation of the underlying molecular mechanisms may provide the basis for future rational pharmacological treatment. In the majority of patients, weakness is static or only slowly progressive, with a favourable long-term outcome.

  7. West and Central Africa.

    Science.gov (United States)

    Lydie, N; Robinson, N J

    1998-01-01

    This article reviews scientific and other literature during the 1990s that links migration and mobility with the spread of sexually transmitted diseases (STDs), including HIV/AIDS. The focus is on key population groups linked to the spread of HIV and STDs in West and Central Africa: migrant laborers, truck drivers, itinerant traders, commercial sex workers (CSWs), and refugees. Countries with high emigration and immigration tend to have high levels of HIV infection, with the exception of Senegal. The main destination of immigrants are Senegal, Nigeria, and Cote d'Ivoire in West Africa and Cameroon, Congo, Gabon, and Congo in Central Africa. The risk of infection and the spread of HIV is variable among migrants. There is little in the literature that substantiates hypotheses about the strong association between migration and HIV-positive status. Information is needed on the duration, frequency of return visits, living conditions, sexual activities with multiple partners, and information before departure, along the routes, at final destination, and at the time of returns. Action-based research in five West African countries (Burkina Faso, Cote d'Ivoire, Mali, Niger, and Senegal) should produce results in late 1998. Comparable studies in Central Africa are unknown. Regional studies should be complemented by local studies. Prevention would benefit from studies on the relative size of these five population groups by geographic location.

  8. Central African Republic.

    Science.gov (United States)

    1986-02-01

    Focus in this discussion of the Central African Republic is on: geography; the people; history and political conditions; government; the economy; foreign relations; and relations with the US. The population of the Central African Republic totaled 2.7 million in 1985 with an annual growth rate of 2.8%. The infant mortality rate is 134/1000 with life expectancy at 49 years. The Central African Republic is at almost the precise center of Africa, about 640 km from the nearest ocean. More than 70% of the population live in rural areas. There are more than 80 ethnic groups, each with its own language. The precolonial history of the area was marked by successive waves of migration, of which little is known. These migrations are responsible for the complex ethnic and linguistic patterns today. United with Chad in 1906, it formed the Oubangui-Chari-Chad colony. In 1910, it became 1 of the 4 territories of the Federation of French Equatorial Africa, along with Chad, Congo, and Gabon. After World War II, the French Constitution of 1946 inaugurated the first of a series of reforms that led eventually to complete independence for all French territories in western and equatorial Africa. The nation became an autonomous republic within the newly established French Community on December 1, 1958, and acceded to complete independence as the Central Africa Republic on August 13, 1960. The government is made up of the executive and the judicial branches. The constitution and legislature remain suspended. All executive and legislative powers, as well as judicial oversight, are vested in the chief of state. The Central African Republic is 1 of the world's least developed countries, with an annual per capita income of $310. 85% of the population is engaged in subsistence farming. Diamonds account for nearly 1/3 of export earnings; the industrial sector is limited. The US terminated bilateral assistance programs in 1979, due to the human rights violations of the Bokassa regime, but modest

  9. Implementing ERMS: Electronic Records Management System Svo uppsker sem sáir. Innleiðing og notkun rafrænna skjalastjórnarkerfa

    Directory of Open Access Journals (Sweden)

    Jóhanna Gunnlaugsdóttir

    2007-12-01

    Full Text Available Abstract in English is unavailable.Lög um aðgengi að upplýsingum í vörslu opinberra aðila og frumkvæði stjórnvalda um rafrænan aðgang að margs konar upplýsingum hafa orðið til þess að opinberar stofnanir og fyrirtæki hafa í vaxandi mæli tekið í notkun rafræn skjalastjórnarkerfi (RSSK. Einkaaðilar hafa einnig tekið kerfi þessi í notkun til þess að hafa stjórn á skjölum sínum. Markmiðið með grein þessari er að fjalla um hvernig best sé að standa að innleiðingu RSSK þannig að útkoman verði víðtæk, almenn og hagkvæm notkun kerfanna meðal þeirra sem ætlað er að nota þau. Rannsóknir hafa leitt í ljós að aðferðir breytingarstjórnunar eigi vel við innleiðingu upplýsingakerfa. Rannsókn var framkvæmd í íslenskum skipulagsheildum um innleiðingu og notkun RSSK. Niðurstöðurnar sýna að stuðningur stjórnenda við innleiðinguna, þátttaka notenda í innleiðingarferlinu og almenn fræðsla um skjalastjórn svo og markviss þjálfun í notkun kerfanna voru forsendur þess að innleiðingin tækist og notkunin yrði eins og til var ætlast. Það gilti jafnt um opinbera aðila sem einkaaðila. Rannsóknin sýndi að sterk tengsl voru á milli innleiðingarþátta og notkunar kerfanna svo og hvort kerfin þóttu notendavæn eða ekki. Það gefur auga leið að kerfisbundinni rafrænni upplýsinga- og skjalastjórn verður einungis komið á með réttri notkun RSSK. Kerfin eru einnig talin forsenda fyrir skilvirkri rafrænni stjórnsýslu. Árangursrík innleiðing þeirra skiptir þess vegna sköpum.

  10. 民族互嵌理论新思考%NEW THINK ING ON THE THEORY OF ETH NIC MUTUAL EMDEDDEDNESS

    Institute of Scientific and Technical Information of China (English)

    刘成

    2015-01-01

    The construction of ethnic mutual embedded social structure and community environment is a new initiative of China ' s national work in the new period .Rather than staying on the levels of building an interests community and emotional community , the construction of ethnic mutual embedded social structure and community environment should served the construction of a destiny community as the pursuit of value , including not only the mutual embeddedness in terms of the form but also the mutual embeddedness of cul -ture, economy and ecology.Several errors ought to be avoided in the course of this construction , i.e .the national problem is a problem of governance strategy , rather than a problem of social structure , fusion can solve all problems, the ethnic mutual embeddedness in foreign countries is served as an altar , attentions are paid to the form of ethnic mutual embeddedness rather than the adjustment of population structure .Based on this and in the combination with the national , provincial and regional conditions of our country , the follow-ing measures should be taken in the construction of ethnic mutual embedded social structure and community environment in order to build a truly mutual tolerance , mutual respect , harmonious coexistence destiny com-munity , the essence of mutual embeddedness:adhering to the modern culture as the lead in the building of ethnic mutual embeddedness jointly , the continuous promotion of people ' s livelihood , the foundation to re-alize ethnic mutual embeddedness , further excavating the local experience in minority areas of our country .%民族互嵌社会结构及社区环境的建构是新时期我国民族工作又一创举. 民族互嵌社会结构和社区环境的建构不能仅仅停留在利益共同体和情感共同体的层面, 而是要以建构命运共同体为价值追求. 民族互嵌不仅仅是形式互嵌, 更是文化、 经济、 生态等的互嵌, 在民族互嵌社会结构和

  11. Central venous catheter - dressing change

    Science.gov (United States)

    ... during cancer treatment Bone marrow transplant - discharge Central venous catheter - flushing Peripherally inserted central catheter - flushing Sterile technique Surgical wound care - open Review Date 9/17/2016 Updated by: ...

  12. Central effects of fingolimod.

    Science.gov (United States)

    Cruz, Vítor T; Fonseca, Joaquim

    2014-08-01

    Introduccion. El fingolimod, un modulador del receptor de la esfingosina-1-fosfato (S1P) dotado de un mecanismo de accion novedoso, fue el primer tratamiento oral aprobado para la esclerosis multiple remitente recurrente. Su union a los receptores S1P1 de los linfocitos promueve la retencion selectiva de los linfocitos T virgenes y de memoria central en los tejidos linfoides secundarios, lo que impide su salida hacia el sistema nervioso central (SNC). Asimismo, el fingolimod atraviesa con facilidad la barrera hematoencefalica, y diversos estudios le atribuyen un efecto neuroprotector directo en el SNC. Objetivo. Revisar la informacion disponible acerca de los efectos centrales del fingolimod. Desarrollo. El desequilibrio entre los procesos lesivos y reparadores constituye un reflejo de la desmielinizacion cronica, la degeneracion axonal y la gliosis, y parece contribuir a la discapacidad que la esclerosis multiple acarrea. La facilidad con la que el fingolimod atraviesa la barrera hematoencefalica le permite actuar directamente sobre los receptores S1P localizados en las celulas del SNC. Una vez en el interior del SNC, ocupa los receptores S1P de los oligodendrocitos y de sus celulas precursoras, de los astrocitos, los microgliocitos y las neuronas, fomentando la remielinizacion, la neuroproteccion y los procesos endogenos de regeneracion. La eficacia evidenciada en los ensayos clinicos concuerda con un mecanismo de accion que incluiria efectos directos sobre las celulas del SNC. Conclusiones. Los datos disponibles indican que la eficacia del fingolimod en el tratamiento de la esclerosis multiple se debe a su ambivalencia como molecula inmunomoduladora y moduladora directa de los receptores S1P del SNC. Tanto es asi que estudios recientes le atribuyen efectos neuroprotectores en varios modelos que suscitan expectativas en torno a su posible aplicacion terapeutica en la enfermedad de Alzheimer, el paludismo cerebral y el neuroblastoma, asi como en la neuroproteccion

  13. [Central anticholinergic syndrome].

    Science.gov (United States)

    Fernández Urretavizcaya, P; Cenoz Osinaga, J C; Jáuregui Garía, M L; Gállego Culleré, J

    1991-10-01

    Two new cases of anticolinergic central syndrome are described. The first case, a 8 year old girl, suffered a severe encefalopathy after topical application of mydriatic cholirio as an aid in a rutine study of ocular refraction. The second case, 67 year old man presented a severe neurological picture after accidental intake of a silvester plantground (Atropa belladonna). His neurological condition returned quickly to normal whith administration of physostigmine. Differents aspects of the etiology, clinical picture and diagnosis are discussed with special emphasis in patients with delirium or acute confusional states. Finally, attention is drawn in the necessity of a properly use of anticholinergic drugs overcoat in aged or children.

  14. Central osteosclerosis with trichothiodystrophy

    Energy Technology Data Exchange (ETDEWEB)

    Wakeling, Emma L.; Brady, Angela F. [North West Thames Regional Genetics Service, Kennedy-Galton Centre, Level 8 V, North West London Hospitals NHS Trust, Watford Road, HAI 3UJ, Harrow, Middlesex (United Kingdom); Cruwys, Michele [Department of Paediatrics, Hillingdon Hospital, Hillingdon, Middlesex (United Kingdom); Suri, Mohnish [Clinical Genetics Service, City Hospital, Nottingham (United Kingdom); Aylett, Sarah E. [Neurosciences Unit, Great Ormond Street Hospital for Children NHS Trust, London (United Kingdom); Hall, Christine [Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, London (United Kingdom)

    2004-07-01

    Trichothiodystrophy (TTD) is a rare, autosomal recessive, multisystem disorder associated with defects in nucleotide excision repair. We report a 7-year-old boy with TTD due to mutation in the XPD gene. The patient has classic features of this condition, including brittle, sulphur-deficient hair, ichthyosis, growth retardation and developmental delay. In addition, he has radiological evidence of progressive central osteosclerosis. Although similar radiological findings have previously been reported in a small number of patients, this association is not widely recognised. We review the radiological findings in this and other similar cases and discuss the natural history of these bony changes. (orig.)

  15. Centralized vs. De-centralized Multinationals and Taxes

    DEFF Research Database (Denmark)

    Nielsen, Søren Bo; Raimondos-Møller, Pascalis; Schjelderup, Guttorm

    2005-01-01

    The paper examines how country tax differences affect a multinational enterprise's choice to centralize or de-centralize its decision structure. Within a simple model that emphasizes the multiple conflicting roles of transfer prices in MNEs - here, as a strategic pre-commitment device and a tax...... manipulation instrument -, we show that (de-)centralized decisions are more profitable when tax differentials are (small) large.Keywords: Centralized vs. de-centralized decisions, taxes, MNEs.JEL-Classification: H25, F23, L23....

  16. Ocorrência e aspectos ecológicos de metazoários parasitos de peixes do Lago do Parque do Ingá, Maringá, Estado do Paraná = Occurrence and ecological aspects of the metazoan fish parasites from Ingá lake, Maringá, Paraná State

    Directory of Open Access Journals (Sweden)

    Marion Haruko Machado

    2007-07-01

    Full Text Available Nenhum estudo de peixes e parasitos foi realizado, até o momento, no Lago do Parque do Ingá que sofre influências antrópicas desde seu represamento, em 1970. Este trabalho analisou alguns aspectos ecológicos dos parasitos metazoários dos peixes deste lago. Dos peixes analisados, (69,5% estavam parasitados por pelo menos uma espécie de parasito. Foram encontrados 1.372 parasitos pertencentes à Nematoda (larvas e Platyhelminthes (Monogenea e Cestoda, sendo estes os mais prevalentes e numerosos. O encontro de larvas decestóides em Tilapia rendalli e Oreochromis niloticus confirma a importância destas espécies como participantes de níveis tróficos intermediários. A maior abundância de T. rendalli e O. niloticus,no local, pode ser um fator determinante no recrutamento de parasitos. O parasito aproveita-se das espécies de hospedeiros mais abundantes para garantir o desenvolvimento de seu ciclo de vida e também por serem os mais disponíveis à predação pelas aves piscívorasali presentes, o que torna o local de grande importância para a sustentação do ciclo de vida desses parasitos. A baixa diversidade de endoparasitos coletados pode ser justificada pela presença de metais pesados – Cu e Pb – no sedimento, o que deve estar interferindo nodesenvolvimento dos invertebrados, possíveis hospedeiros intermediários.Ingá lake was dammed in 1970 and, since then, no study on fish and parasites had been done, but it has suffered anthropic influences. This study analyzed some ecological aspects of the metazoan parasites form this lake. From analyzed fish, 69.5% had at least one species of parasite. Among them, 1.372 parasites were found, prevailing Nematoda (larvae and Platyhelminthes (Monogenea and Cestoda. The discovery of cestode larvae in Tilapia rendalli and Oreochromis nitolicus confirms the importance of these species as participants of intermediate trophic levels. The great number of Tilapia rendalli and Oreochromis nitolicus

  17. Central centrifugal cicatricial alopecia.

    Science.gov (United States)

    Whiting, David A; Olsen, Elise A

    2008-01-01

    A progressive scarring alopecia of the central scalp is commonly seen in young to middle-aged females of African descent. It usually starts at the vertex or mid top of the scalp and gradually spreads centrifugally, hence, the unifying term of central centrifugal cicatricial alopecia. The clinical pattern is suggestive of female pattern alopecia, but a lack of follicular pores indicative of scarring is present. It can progress for years before slowly burning out. The etiology is unknown but genetic factors may be important. It is often associated with a history of traumatic hairstyling involving heat, traction, and chemicals. However, most patients of African descent without this disorder have similar styling habits. Nonetheless, avoidance of physical and chemical trauma to the scalp hair, the use of suitable shampoos and conditioners, and the encouragement of natural hairstyles may be helpful. Any infection should be treated. Topical or intralesional corticosteroids and systemic antibiotics may be useful and topical minoxidil should be tried with the hope of preventing further scarring and encouraging regrowth of recovering follicles. Current research into the etiology of this disorder will help to foster much-needed clinical trials of therapeutic agents.

  18. Central Sumatra enjoys success

    Energy Technology Data Exchange (ETDEWEB)

    Wongsosantiko, A.

    1977-05-02

    The Sihapas group contains the most prolific oil producing zones in the Central Sumatra Basin. It represents the transgressive, coarse clastic sequence deposited during the early Miocene. Some of these sandstone grade laterally into siltstones and shales of the Telisa Formation, believed to be a major source of rock for Central Sumatra oil. Recent exploratory wells drilled between the mountain front and coastal plain areas have provided more data for stratigraphic studies. These have resulted in subdivision of the lower Miocene transgressive sequence into discrete rock-stratigraphic units. The former Sihapas Formation has subsequently been elevated to group rank and now consists of several formations with the Duri Formation as the uppermost sand unit. This study covers Caltex's areas of operation, which includes the area between the Kampar River of the south, the Barumum River to the north, the Malacca Straits to the east, and the Barisan Mt. to the west. A basic map shows the regional scene, while a stratigraphic chart shows the lithology.

  19. en los pivotes centrales

    Directory of Open Access Journals (Sweden)

    Reynaldo Roque Rodés

    2005-01-01

    Full Text Available Se hace una revisión y comentarios sobre las ventajas y limitantes del empleo del LEPA (Low Enery Precision Aplication en los sistemas de riego de pivotes centrales. Estos sistemas o filosofía de manejo del agua para condiciones de escasez o mala calidad del líquido es una alternativa viable para la producción de alimentos. Introducida en la década del 80 en las planicies del sur de Texas, donde la alta evaporación del agua y la necesidad de regar grandes áreas con pivotes centrales obligaba a la búsqueda de una alternativa para incrementar al máximo la eficiencia de aplicación del riego. Aún en fase de estudio e introducción en Cuba para áreas específicas, puede ser una solución de incremento de los rendimientos de los cultivos, empleando menos agua y aguas con calidad limitada

  20. STUDY CONCERNING THE ASSESSMENT AND EVALUATION OF HUMAN FACTOR IN S.C. HIDROELECTRICA S.A., CURTEA DE ARGEȘ

    Directory of Open Access Journals (Sweden)

    SECARĂ CARMEN-GABRIELA

    2014-08-01

    Full Text Available The assessment of professional performance is a delicate problem in the organization management. When it comes to training, payment or promotion, all these operations only take place following an assessment. The purpose of the assessment is to assist in making decisions that affect individuals, which decisions should have an objective and fair basis. The need for this activity is dictated by: the expression and sizing of the objectives, setting deviations from the objectives and making the necessary corrections, determining the directions and methods for the refresher training of the staff, decreasing the risks r caused by retaining and promoting incompetent persons, a better assignment of the employees on positions, fair salaries, increasing the competitive capacity of the organization. All these are explicit functions of the performance assessment, but there are also implicit reasons. Assessment is an activity through which employees are motivated, personal contacts are maintained, high-quality work is recognised, and a certain image of the assessed employee is promoted.[2] Knowing then performance achieved involves an understanding of how tasks are fulfilled, the yield at the workplace. Knowing performance offers the assessed person self-confidence, and is also a mobilizing factor that generates a positive attitude towards work.

  1. Centrality Measures in Urban Networks

    CERN Document Server

    Crucitti, P; Porta, S; Crucitti, Paolo; Latora, Vito; Porta, Sergio

    2005-01-01

    Centrality has revealed crucial for understanding the structural order of complex relational networks. Centrality is also relevant for various spatial factors affecting human life and behaviors in cities. We present a comprehensive study of centrality distributions over geographic networks of urban streets. Four different measures of centrality, namely closeness, betweenness, straightness and information, are compared over eighteen 1-square-mile samples of different world cities. Samples are represented by primal geographic graphs, i.e. valued graphs defined by metric rather than topologic distance where intersections are turned into nodes and streets into edges. The spatial behavior of centrality indexes over the networks is investigated graphically by means of colour-coded maps. The results indicate that a spatial analysis, that we term Multiple Centrality Assessment(MCA), grounded not a single but on a set of different centrality indices, allows an extended comprehension of the city structure, nicely captu...

  2. Orden monetario y bancos centrales Monetary order and Central Banks

    Directory of Open Access Journals (Sweden)

    Aglietta Michel

    1996-06-01

    Full Text Available Con el enfoque evolucionista e institucionalista de la economía de las convenciones francesa, este trabajo analiza el surgimiento histórico de la banca central y la creación institucional del 'arte de la banca central'. El artículo estudia los modelos formales del orden monetario, la banca libre y la banca central, y analiza los eventos históricos que llevaron a que el Banco de Inglaterra inventara el arte de manejar los bancos centrales en conjunción con el aprendizaje colectivo e institucional que lo hizo posible. Aglietta muestra que la banca central no es una creación del Estado sino una creación institucional endógena al sistema de mercado.With the evolutionist and institutionalist focus of the economics of the French conventions, this paper analyzes the historical rise of the central bank and the institutional creation of the 'art of the central bank'. The article studies formal models of the monetary order, free banking and the central bank, and analyzes the historie events that led to the Bank of England inventing the art of managing the central banks, in conjunction with the collective and institutional learning that made it possible. Aglietta shows that the central bank is not a creation of the State, but rather aninstitutional creation endogenous to the market system.

  3. UA1 central detector

    CERN Multimedia

    The UA1 central detector was crucial to understanding the complex topology of proton-antiproton events. It played a most important role in identifying a handful of Ws and Zs among billions of collisions. The detector was a 6-chamber cylindrical assembly 5.8 m long and 2.3 m in diameter, the largest imaging drift chamber of its day. It recorded the tracks of charged particles curving in a 0.7 Tesla magnetic field, measuring their momentum, the sign of their electric charge and their rate of energy loss (dE/dx). Atoms in the argon-ethane gas mixture filling the chambers were ionised by the passage of charged particles. The electrons which were released drifted along an electric field shaped by field wires and were collected on sense wires. The geometrical arrangement of the 17000 field wires and 6125 sense wires allowed a spectacular 3-D interactive display of reconstructed physics events to be produced.

  4. UA2 central calorimeter

    CERN Multimedia

    The UA2 central calorimeter measured the energy of individual particles created in proton-antiproton collisions. Accurate calibration allowed the W and Z masses to be measured with a precision of about 1%. The calorimeter had 24 slices like this one, each weighing 4 tons. The slices were arranged like orange segments around the collision point. Incoming particles produced showers of secondary particles in the layers of heavy material. These showers passed through the layers of plastic scintillator, generating light which was taken by light guides (green) to the data collection electronics. The amount of light was proportional to the energy of the original particle. The inner 23 cm of lead and plastic sandwiches measured electrons and photons; the outer 80 cm of iron and plastic sandwiches measured strongly interacting hadrons. The detector was calibrated by injecting light through optical fibres or by placing a radioactive source in the tube on the bottom edge.

  5. L'idéal technocratique des ingénieurs à l'épreuve de la construction de l’Etat : Maghreb, Machrek, Indochine au XXe siècle

    Directory of Open Access Journals (Sweden)

    Anousheh Karvar

    2009-05-01

    Full Text Available Dans cet article, nous suggérons de dégager les lignes de force des trajectoires individuelles d'un groupe de diplômés de grandes écoles françaises – les polytechniciens – originaires de l'Afrique du Nord, de l'Indochine ou du Moyen-Orient. Grâce à leur engagement dans les mouvements nationaux et de libération, les premiers ingénieurs formés en France se sont vus confier, avec les indépendances, le contrôle technique de l'activité économique. Or, une fois aux commandes des secteurs clés de l'économie, ils ont revendiqué une impartialité politique en contraste avec leur engagement précédent comme avec leur rôle de médiateur stratégique de la modernisation. En interrogeant l'idéal technocratique de ces ingénieurs d'État, produit contradictoire de la science acquise en Occident et de l'aspiration à l'indépendance, nous proposons quelques hypothèses d'explication sur l'implantation inachevée du modèle étatique de facture française dans les pays étudiés.

  6. The study of high temperature disaster risk zoning in Beij ing-Tianj in-Hebei urban agglomeration%京津冀城市群高温灾害风险区划研究

    Institute of Scientific and Technical Information of China (English)

    杜吴鹏; 权维俊; 轩春怡; 房小怡; 郭文利

    2014-01-01

    northern part of Hebei Province,such as Chengde,Zhangj iakou and Qinhuangdao has the lowest probability for high temperature event.The regions where the disaster factors and environments are the most sensitive mainly located in the south of Hebei,as while as,the most vulnerable regions of bearing body mainly distributed in large cities.The developed regions have greater capacity in resisting high temperature disaster,and their risk index is lower.The integrated risk zoning of high temperature disaster in Beijing-Tianjin-Hebei urban agglomeration is characterized that it is higher in the south and lower in the north,the highest-risk areas concentrated in the southern Hebei and the urban areas of Beijing and Tianjin,meanwhile,they are the higher-risk or moderate-risk areas in the central of Hebei and the neighboring regions of Beij ing and Tianj in.While,in the north,northwest and northeast,they are the lowest-risk or lower-risk areas.Comprehensive analyzing high temperature risk regional differences and researching the zoning method in Beijing-Tianjin-Hebei urban agglomeration can provide a scientific basis and reference for other meteorological disaster evaluation.

  7. Central Disorders of Hypersomnolence

    Science.gov (United States)

    Khan, Zeeshan

    2015-01-01

    The central disorders of hypersomnolence are characterized by severe daytime sleepiness, which is present despite normal quality and timing of nocturnal sleep. Recent reclassification distinguishes three main subtypes: narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia (IH), which are the focus of this review. Narcolepsy type 1 results from loss of hypothalamic hypocretin neurons, while the pathophysiology underlying narcolepsy type 2 and IH remains to be fully elucidated. Treatment of all three disorders focuses on the management of sleepiness, with additional treatment of cataplexy in those patients with narcolepsy type 1. Sleepiness can be treated with modafinil/armodafinil or sympathomimetic CNS stimulants, which have been shown to be beneficial in randomized controlled trials of narcolepsy and, quite recently, IH. In those patients with narcolepsy type 1, sodium oxybate is effective for the treatment of both sleepiness and cataplexy. Despite these treatments, there remains a subset of hypersomnolent patients with persistent sleepiness, in whom alternate therapies are needed. Emerging treatments for sleepiness include histamine H3 antagonists (eg, pitolisant) and possibly negative allosteric modulators of the gamma-aminobutyric acid-A receptor (eg, clarithromycin and flumazenil). PMID:26149554

  8. [MANAGEMENT OF CENTRAL HYPERSOMNIAS].

    Science.gov (United States)

    Dauvilliers, Yves; Lopez, Régis

    2016-06-01

    Central hypersomnias include narcolepsy type 1, type 2 and idiopathic hypersomnia with daytime sleepiness excessive in the foreground of the clinical symptoms. Despite major advances in our understanding of the mechanisms of the narcolepsy type 1 with a low level of hypocretin-1 in cerebrospinal fluid, its current management is only symptomatic. The current management is also only symptomatic for type 2 narcolepsy and idiopathic hypersomnia with an unknown pathophysiology. Treatment options may vary from a single drug targeting several symptoms or several drugs treating a specific symptom. The treatment of daytime sleepiness is based on modafinil in first intention. Other psychostimulants such as methylphenidate, pitolisant and exceptionally dextro-amfetamine may be considered. In narcolepsy type 1, antidepressants such as inhibitors of the reuptake of serotonin and noradrenaline will be considered to improve cataplexy. Sodium oxybate is an effective treatment on sleepiness, cataplexy and bad night sleep in narcolepsy. The management for other symptoms or comorbidities should be considered it necessary such as hallucinations, sleep paralysis, the disturbed nighttime sleep, unpleasant dreams, parasomnias, depressive symptoms, overweight/obesity, cardiovascular disease and obstructive sleep apnea syndrome. Important therapeutic perspectives are to be expected concerning new psychostimulant and anticataplectiques, but mainly on immune-based therapies administered as early as possible after disease onset and on hypocretin replacement therapy for patients with severe symptoms.

  9. Ferrule Designs and Stress Distribution in Endodontically Treated Upper Central Incisors: 3D Finite Element Analysis

    Directory of Open Access Journals (Sweden)

    A. Hassan Ahangari

    2008-09-01

    Full Text Available Objective: The main goal of this study was to evaluate stress distribution of endodonti-cally treated maxillary central incisors restored with glass fiber posts, composite resin cores, and crowns with different ferrule designs.Materials and Methods: Four three-dimensional models of a maxillary central incisor were modeled in SolidWorks 2006. Tooth with no ferrule, tooth with a 2 mm circumferen-tial ferrule, tooth with a 2 mm beveled ferrule and tooth with a 0.5 mm circumferential ferrule. The teeth were restored with glass fiber posts, composite resin cores, and full ce-ramics crowns. Each model was loaded (1 N on the palatal side at an angle of 45 degrees to tooth long axis. Von Mises stress findings along the inner surface of the root canals were assessed and compared.Results: The Von Mises Stress at CEJ was the highest in the model without a ferrule when compared to the other models (without ferrule 0.0696, short ferrule 0.0492, cylindrical fer-rule 0.0248, and beveled ferrule 0.0387 MPa.Conclusion: Endodontically treated maxillary central incisors with a ferrule length vary-ing between 0.5 mm and 2.0 mm exhibit lower stress distribution compared to those with-out a ferrule. Keeping a long ferrule is suggested to decrease the stress at the cervical area of restored teeth.

  10. Dinamismo econômico e batismos de ingênuos: a libertação do ventre da escrava em Casa Branca e Iguape, província de São Paulo (1871-1885

    Directory of Open Access Journals (Sweden)

    José Flávio Motta

    2008-01-01

    Full Text Available Estudamos os batismos de ingênuos registrados nas localidades paulistas de Iguape e Casa Branca entre 1871 e 1885. Nesse período, houve em Iguape o esmorecimento do dinamismo econômico assentado no cultivo de arroz destinado ao mercado interno. Já Casa Branca achava-se próxima à fronteira da expansão da lavoura cafeeira na província. Com a ênfase posta na comparação entre esses dois municípios, com vistas a explorar o condicionamento exercido por seus díspares panos de fundo econômicos, analisamos as características dos registros aludidos. Observamos a freqüência dos batizados no tempo, bem como computamos a distribuição, de acordo com a condição de legitimidade, das crianças nascidas de mães escravas após a promulgação da Lei do Ventre Livre. Acompanhamos o comportamento da defasagem temporal entre a data do nascimento e a do batismo. Avançamos, com fundamento em dois estudos de caso, um para cada uma das localidades selecionadas, algumas considerações acerca dos intervalos intergenésicos. Por fim, voltamos nossa atenção para a condição social de padrinhos e madrinhas. Mostraram-se muito expressivas, regra geral, as disparidades entre Iguape e Casa Branca.We study the baptisms of ingênuos registered in the localities of Iguape and Casa Branca, both in the province of São Paulo, in the period 1871-1885. Iguape, in those years, saw a slackening of the economic dynamism based on rice cultivation for the internal market. Casa Branca, on the other hand, was near the expansion frontier of coffee culture in the province. We emphasize the comparison between the characteristics of the registers of baptisms of ingênuos preserved for those two cities to explore the impact of their different economic contexts. We observe the frequency in time of the baptisms of children born of slave mothers after de promulgation of the Ventre-Livre Law. In addition, we compute the distribution of baptisms according to legitimacy

  11. y Banca Central

    Directory of Open Access Journals (Sweden)

    Ángel García Banchs

    2008-01-01

    Full Text Available Las teorías monetarias modernas, ortodoxas y heterodoxas, han pasado por alto el hecho de que posterior a la Segunda Guerra Mundial el mundo quedó dividido entre economías emisoras y receptoras de reservas, pasando el sistema monetario internacional desde entonces a ser completamente asimétrico. De allí que, desde el punto de vista teórico, señalemos la necesidad de tomar en cuenta si las economías emiten o no una moneda de reserva internacional, pues ello explicaría la existencia de diversas prácticas monetarias a nivel mundial. Este trabajo propone, y calcula, indicadores basados en datos provenientes de los balances de activos y pasivos de quince bancos centrales pertenecientes a Norteamérica, Suramérica, Europa y Asia. Los hallazgos con respecto a las diversas estructuras de activos y pasivos confirman la hipótesis acerca de la presencia de tales asimetrías. Se infiere en consecuencia que la política monetaria es menos flexible pero más influyente en las economías receptoras de reservas, y a la vez más flexible pero menos influyente en las economías emisoras. En pocas palabras, la exogeneidad de la tasa de interés de corto plazo es más débil en el caso de las economías receptoras de reservas las cuales se ven obligadas a acumular divisas y a procurar la estabilidad del tipo de cambio, debido a que sus monedas locales no son aceptadas en el exterior. Así, aunque la oferta crediticia es endógena en esas economías, las mismas no han sido capaces de librarse aún de la necesidad de mantener reservas monetarias en divisas extranjeras

  12. Dublin South Central (DSC)

    LENUS (Irish Health Repository)

    O'Gorman, Clodagh S M

    2010-12-01

    Children who appear healthy, even if they have one or more recognized cardiovascular risk factors, do not generally have outcomes of cardiovascular or other vascular disease during childhood. Historically, pediatric medicine has not aggressively screened for or treated cardiovascular risk factors in otherwise healthy children. However, studies such as the P-Day Study (Pathobiological Determinants of Atherosclerosis in Youth), and the Bogalusa Heart Study, indicate that healthy children at remarkably young ages can have evidence of significant atherosclerosis. With the increasing prevalence of pediatric obesity, can we expect more health problems related to the consequences of pediatric dyslipidemia, hypertriglyceridemia, and atherosclerosis in the future? For many years, medications have been available and used in adult populations to treat dyslipidemia. In recent years, reports of short-term safety of some of these medications in children have been published. However, none of these studies have detailed long-term follow-up, and therefore none have described potential late side-effects of early cholesterol-lowering therapy, or potential benefits in terms of reduction of or delay in cardiovascular or other vascular end-points. In 2007, the American Heart Association published a scientific statement on the use of cholesterol-lowering therapy in pediatric patients. In this review paper, we discuss some of the current literature on cholesterol-lowering therapy in children, including the statins that are currently available for use in children, and some of the cautions with using these and other cholesterol-lowering medications. A central tenet of this review is that medications are not a substitute for dietary and lifestyle interventions, and that even in children on cholesterol-lowering medications, physicians should take every opportunity to encourage children and their parents to make healthy diet and lifestyle choices.

  13. Central African Republic.

    Science.gov (United States)

    1989-11-01

    The Central African Republic contains 242,000 square miles, which rolling terrain almost 2000 feet above sea level. The climate is tropical, and it has a population of 2.8 million people with a 2.5% growth rate. There are more than 80 ethnic groups including Baya 34%, Banda 28%, Sara 10%, Mandja 9%, Mboum 9%, and M'Baka 7%. The religions are traditional African 35%, protestant 25%, Roman Catholic 25%, and Muslim 15%, and the languages are French and Sangho. The infant mortality rate is 143/1000, with expectancy at 49 years and a 40% literacy rate. The work force of 1 million is 70% agricultural, industry 6% and commerce and service 6% and government 3%. The government consists of a president assisted by cabinet ministers and a single party. Natural resources include diamonds, uranium, timber, gold, and oil, and major industries are beverages, textiles, and soap. Agricultural products feature coffee, cotton, peanuts, tobacco, food crops and livestock. Most of the population live in rural areas and most of the 80 ethnic groups have their own language. This is one of the world's least developed countries, with a per capita income of $375/year. The main problems with development are the poor transportation infrastructure, and the weak internal and international marketing systems. The US and various international organizations have aided in agriculture development, health programs, and family planning. US investment is mainly in diamond and gold mining, and although oil drilling has been successful it is not economically feasible at current prices.

  14. Central Hypothyroidism in Miniature Schnauzers

    NARCIS (Netherlands)

    Voorbij, Annemarie M W Y; Leegwater, Peter A J; Buijtels, Jenny J C W M; Daminet, Sylvie; Kooistra, Hans S

    2016-01-01

    BACKGROUND: Primary hypothyroidism is a common endocrinopathy in dogs. In contrast, central hypothyroidism is rare in this species. OBJECTIVES: The objective of this article is to describe the occurrence and clinical presentation of central hypothyroidism in Miniature Schnauzers. Additionally, the p

  15. Sustainability Assessment of a Self-Consumption Wood-Energy Chain on Small Scale for Heat Generation in Central Italy

    Directory of Open Access Journals (Sweden)

    Stefano Verani

    2015-06-01

    Full Text Available The sustainability of a small-scale self-consumption wood-energy chain for heat generation in central Italy was analyzed from a technical, economic and energetic point of view. A micro-chain was developed within the CRA-ING farm at Monterotondo (Rome, Italy: The purpose of this system was to produce biomass for supplying a heating plant within the CRA-ING property as a substitute for diesel fuel. A poplar short rotation coppice, established with clones AF2, AF6 and Monviso, fed the micro-chain. The rotation was biennial. The average plantation production (Mgd.m.·ha−1·year−1 was 10.2, with a maximum of 13.53 for the twin-rows AF2 and a minimum of 8.00 for the single-row Monviso. The economic assessment was based on the Net Present Value (NPV method and the equivalent annuity cost, and found an average saving of 15.60 €·GJ−1 of heat generated by the wood chips heating system in comparison with the diesel heating system over a 10 year lifetime of the thermal power plant. The energy assessment of the poplar plantation, carried out using the Gross Energy Requirements method, reported an energy output/input ratio of 12.3. The energy output/input ratio of the whole micro-chain was 4.5.

  16. Central presbycusis: an emerging view.

    Science.gov (United States)

    Gates, George A

    2012-07-01

    Age-related dysfunction of the central auditory system (central presbycusis) is common but rarely looked for by those who provide aural rehabilitation. Patients who complain of difficulty hearing in noise--the key symptom of central presbycusis--are generally disadvantaged with conventional rehabilitation. This symptom should be documented with commercially available speech-in-noise tests, which use materials that are uncomplicated to administer. Those patients who perform poorly on such tests should have a customized rehabilitation program aimed at optimizing their remaining communication abilities. Otolaryngologists who provide auditory rehabilitation may wish to consider expanding their practices to meet the communication needs of older patients with central presbycusis. Central presbycusis is an emerging area for basic and clinical research in auditory neurotology, particularly in the relation of cognitive dysfunction to impaired auditory processing.

  17. Savoirs militaires et modernité urbaine coloniale. Le rôle des ingénieurs du génie dans la transformation des villes algériennes : le cas d’Oran (1831- 1870)

    OpenAIRE

    Benkada, Saddek

    2013-01-01

    Oran avait été, en raison de son passé d’enclave militaire espagnole, une importante place de guerre conçue sur le modèle européen. Le port de guerre de Mers,el,Kébir constituait un important point d’appui maritime. Stratégiquement, Oran et son port de guerre furent parmi les premiers établissements à être occupés par les troupes françaises en 1831.L’administration civile de la ville et, en particulier, les services techniques constitués par de rares ingénieurs civils sont restés pendant long...

  18. Centralized versus Decentralized Information Systems

    Science.gov (United States)

    Hugoson, Mats-Åke

    This paper brings into question whether information systems should be centralized or decentralized in order to provide greater support for different business processes. During the last century companies and organizations have used different approaches for centralization and decentralization; a simple answer to the question does not exist. This paper provides a survey of the evolution of centralized and decentralized approaches, mainly in a Nordic perspective. Based on critical reflections on the situation in the end of the century we can discuss what we can learn from history to achieve alignment between centralized and decentralized systems and the business structure. The conclusion is that theories, management and practice for decisions on centralization or decentralization of information systems must be improved. A conscious management and control of centralization /decentralization of IT support is a vital question in the company or the organization, and this is not a task that can be handled only by IT-specialists. There is a need for business oriented IT management of centralization/decentralization.

  19. Betweenness centrality profiles in trees

    CERN Document Server

    Fish, Benjamin; Turan, Gyorgy

    2016-01-01

    Betweenness centrality of a vertex in a graph measures the fraction of shortest paths going through the vertex. This is a basic notion for determining the importance of a vertex in a network. The k-betweenness centrality of a vertex is defined similarly, but only considers shortest paths of length at most k. The sequence of k-betweenness centralities for all possible values of k forms the betweenness centrality profile of a vertex. We study properties of betweenness centrality profiles in trees. We show that for scale-free random trees, for fixed k, the expectation of k-betweenness centrality strictly decreases as the index of the vertex increases. We also analyze worst-case properties of profiles in terms of the distance of profiles from being monotone, and the number of times pairs of profiles can cross. This is related to whether k-betweenness centrality, for small values of k, may be used instead of having to consider all shortest paths. Bounds are given that are optimal in order of magnitude. We also pre...

  20. Demographic tensions in Central America.

    Science.gov (United States)

    1986-08-01

    This discussion of Central America focuses on the rapid growth of its population, its stagnating economy, and those countries that are socioeconomically advanced. Between 1950-85 the population of Central America tripled, from 9.1 million to 26. 4 million, due to marked mortality declines and the absence of off-setting fertility declines. The distribution of Central Americas's growing populations sets its population growth apart from that of other developing regions. Currently, almost half of all Central Americans live in cities. Although the average growth rate for Central American countries has fallen and is expected to drop further, the decline does not counterbalance the effect of the absolute rise in population numbers. The average annual growth rate of more than 3% annually in the 1960s fell to about 2.6% in recent years, but this decline is due primarily to socioeconomically advanced Costa Rica and Panama. Central America's age structure further complicates the population crisis. About 43% of Central Americans are under the age of 15. When the increasingly larger young population group enters it reproductive years, the potential for future growth (albeit the falling rate of population increase) is unparalleled. UN population projections show the region's population at 40 million by the year 2000. The 1973 oil crisis began a downward spiral for the buoyant post World War II Central American economy. Between 1950-79, real per capita income growth in Central America doubled, with Central American economies growing an average of 5.3% annually. By the early 1980s, overseas markets of the trade-dependent countries of Central America had dried up due to protectionism abroad and slumping basic commodity prices. These and other factors plunged Central America into its current economic malaise of falling real per capita income, rising unemployment, curtailed export led economic growth, and a rising cost of living. In general, economic growth in Central America

  1. The Central Trigger Processor (CTP)

    CERN Multimedia

    Franchini, Matteo

    2016-01-01

    The Central Trigger Processor (CTP) receives trigger information from the calorimeter and muon trigger processors, as well as from other sources of trigger. It makes the Level-1 decision (L1A) based on a trigger menu.

  2. Payments and Central Bank Policy

    DEFF Research Database (Denmark)

    Korsgaard, Søren

    This thesis consists of three chapters. The rst, "Paying for Payments", examines the role of interchange fees in payment card networks. The second, "Bank Liquidity and the Interbank Market" (co-authored with Mikael Reimer Jensen), investigates how banks' liquidity holdings at the central bank a ect...... outcomes in the money market. The third, "Collateralized Lending and Central Bank Collateral Policy", considers the emergence of credit constraints under collateralized lending, and how central banks use collateral policy to mitigate these constraints. While the chapters can be read independently......, they share common themes. Each chapter is concerned with payments in one way or another, each is concerned with the e ciency of market outcomes, and, to the extent that there is scope for improving these outcomes, each discusses the appropriate role for policy, in particular central bank policy....

  3. Central cementifying fibroma of mandible

    Directory of Open Access Journals (Sweden)

    Joseph Edward

    2010-01-01

    Full Text Available Central cementifying fibroma is a rare non odontogenic tumor coming in the group of fibro osseouslesion, arising from periodontal ligament and is usually seen in tooth bearing area. It can affect boththe mandible and the maxilla, particularly the mandible. This bone tumour consists of highly cellular,fibrous tissue that contains varying amounts of calcified tissue resembling bone, cementum or both.Here we present a case of Central cementifying fibroma (recurrent in a 34 year old female.

  4. Inferring Centrality from Network Snapshots

    OpenAIRE

    Haibin Shao; Mehran Mesbahi; Dewei Li; Yugeng Xi

    2017-01-01

    The topology and dynamics of a complex network shape its functionality. However, the topologies of many large-scale networks are either unavailable or incomplete. Without the explicit knowledge of network topology, we show how the data generated from the network dynamics can be utilised to infer the tempo centrality, which is proposed to quantify the influence of nodes in a consensus network. We show that the tempo centrality can be used to construct an accurate estimate of both the propagati...

  5. CENTRAL PLATEAU REMEDIATION OPTIMIZATION STUDY

    Energy Technology Data Exchange (ETDEWEB)

    BERGMAN, T. B.; STEFANSKI, L. D.; SEELEY, P. N.; ZINSLI, L. C.; CUSACK, L. J.

    2012-09-19

    THE CENTRAL PLATEAU REMEDIATION OPTIMIZATION STUDY WAS CONDUCTED TO DEVELOP AN OPTIMAL SEQUENCE OF REMEDIATION ACTIVITIES IMPLEMENTING THE CERCLA DECISION ON THE CENTRAL PLATEAU. THE STUDY DEFINES A SEQUENCE OF ACTIVITIES THAT RESULT IN AN EFFECTIVE USE OF RESOURCES FROM A STRATEGIC PERSPECTIVE WHEN CONSIDERING EQUIPMENT PROCUREMENT AND STAGING, WORKFORCE MOBILIZATION/DEMOBILIZATION, WORKFORCE LEVELING, WORKFORCE SKILL-MIX, AND OTHER REMEDIATION/DISPOSITION PROJECT EXECUTION PARAMETERS.

  6. Controlling centrality in complex networks

    CERN Document Server

    Nicosia, Vincenzo; Romance, Miguel; Russo, Giovanni; Latora, Vito

    2011-01-01

    Spectral centrality measures allow to identify influential individuals in social groups, to rank Web pages by their popularity, and even to determine the impact of scientific researches. The centrality score of a node within a network crucially depends on the entire pattern of connections, so that the usual approach is to compute the node centralities once the network structure is assigned. We face here with the inverse problem, that is, we study how to modify the centrality scores of the nodes by acting on the structure of a given network. We prove that there exist particular subsets of nodes, called controlling sets, which can assign any prescribed set of centrality values to all the nodes of a graph, by cooperatively tuning the weights of their out-going links. We show that many large networks from the real world have surprisingly small controlling sets, containing even less than 5-10% of the nodes. These results suggest that rankings obtained from spectral centrality measures have to be considered with ex...

  7. Flux analysis of central metabolic pathways in Geobactermetallireducens during reduction of solubleFe(III)-NTA

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Yinjie J.; Chakraborty, Romy; Garcia-Martin, Hector; Chu,Jeannie; Hazen, Terry C.; Keasling, Jay D.

    2007-01-01

    We analyzed the carbon fluxes in the central metabolism ofGeobacter metallireducens strain GS-15 using 13C isotopomer modeling.Acetate labeled in the 1st or 2nd position was the sole carbon source,and Fe-NTA was the sole terminal electron acceptor. The measured labeledacetate uptake rate was 21 mmol/gdw/h in the exponential growth phase.The resulting isotope labeling pattern of amino acids allowed an accuratedetermination of the in vivo global metabolic reaction rates (fluxes)through the central metabolic pathways using a computational isotopomermodel. The tracer experiments showed that G. metallireducens containedcomplete biosynthesis pathways for essential metabolism, and this strainmight also have an unusual isoleucine biosynthesis route (usingacetyl-CoA and pyruvate as the precursors). The model indicated that over90 percent of the acetate was completely oxidized to CO2 via a completetricarboxylic acid (TCA) cycle while reducing iron. Pyruvate carboxylaseand phosphoenolpyruvate carboxykinase were present under theseconditions, but enzymes in the glyoxylate shunt and malic enzyme wereabsent. Gluconeogenesis and the pentose phosphate pathway were mainlyemployed for biosynthesis and accounted for less than 3 percent of totalcarbon consumption. The model also indicated surprisingly highreversibility in the reaction between oxoglutarate and succinate. Thisstep operates close to the thermodynamic equilibrium possibly becausesuccinate is synthesized via a transferase reaction, and the conversionof oxoglutarate to succinate is a rate limiting step for carbonmetabolism. These findings enable a better understanding of therelationship between genome annotation and extant metabolic pathways inG. metallireducens.

  8. In the presence of danger:the extracellular matrix defensive response to central nervous system injury

    Institute of Scientific and Technical Information of China (English)

    Lyn B. Jakeman; Kent E. Williams; Bryan Brautigam

    2014-01-01

    Glial cells in the central nervous system (CNS) contribute to formation of the extracellular matrix, which provides adhesive sites, signaling molecules, and a diffusion barrier to enhance efifcient neurotransmission and axon potential propagation. In the normal adult CNS, the extracellular matrix (ECM) is relatively stable except in selected regions characterized by dynamic remodel-ing. However, after trauma such as a spinal cord injury or cortical contusion, the lesion epicenter becomes a focus of acute neuroinlfammation. The activation of the surrounding glial cells leads to a dramatic change in the composition of the ECM at the edges of the lesion, creating a perile-sion environment dominated by growth inhibitory molecules and restoration of the peripheral/central nervous system border. An advantage of this response is to limit the invasion of damaging cells and diffusion of toxic molecules into the spared tissue regions, but this occurs at the cost of inhibiting migration of endogenous repair cells and preventing axonal regrowth. The following review was prepared by reading and discussing over 200 research articles in the ifeld published in PubMed and selecting those with signiifcant impact and/or controversial points. This article highlights structural and functional features of the normal adult CNS ECM and then focuses on the reactions of glial cells and changes in the perilesion border that occur following spinal cord or contusive brain injury. Current research strategies directed at modifying the inhibitory perile-sion microenvironment without eliminating the protective functions of glial cell activation are discussed.

  9. Rosette Central Configurations, Degenerate central configurations and bifurcations

    CERN Document Server

    Lei, Jinzhi

    2009-01-01

    In this paper we find a class of new degenerate central configurations and bifurcations in the Newtonian $n$-body problem. In particular we analyze the Rosette central configurations, namely a coplanar configuration where $n$ particles of mass $m_1$ lie at the vertices of a regular $n$-gon, $n$ particles of mass $m_2$ lie at the vertices of another $n$-gon concentric with the first, but rotated of an angle $\\pi/n$, and an additional particle of mass $m_0$ lies at the center of mass of the system. This system admits two mass parameters $\\mu=m_0/m_1$ and $\\ep=m_2/m_1$. We show that, as $\\mu$ varies, if $n> 3$, there is a degenerate central configuration and a bifurcation for every $\\ep>0$, while if $n=3$ there is a bifurcations only for some values of $\\epsilon$.

  10. Coverage centralities for temporal networks

    CERN Document Server

    Takaguchi, Taro; Yoshida, Yuichi

    2015-01-01

    Structure of real networked systems, such as social relationship, can be modeled as temporal networks in which each edge appears only at the prescribed time. Understanding the structure of temporal networks requires quantifying the importance of a temporal vertex, which is a pair of vertex index and time. In this paper, we define two centrality measures of a temporal vertex by the proportion of (normal) vertex pairs, the quickest routes between which can (or should) use the temporal vertex. The definition is free from parameters and robust against the change in time scale on which we focus. In addition, we can efficiently compute these centrality values for all temporal vertices. Using the two centrality measures, we reveal that distributions of these centrality values of real-world temporal networks are heterogeneous. For various datasets, we also demonstrate that a majority of the highly central temporal vertices are located within a narrow time window around a particular time. In other words, there is a bo...

  11. Coverage centralities for temporal networks*

    Science.gov (United States)

    Takaguchi, Taro; Yano, Yosuke; Yoshida, Yuichi

    2016-02-01

    Structure of real networked systems, such as social relationship, can be modeled as temporal networks in which each edge appears only at the prescribed time. Understanding the structure of temporal networks requires quantifying the importance of a temporal vertex, which is a pair of vertex index and time. In this paper, we define two centrality measures of a temporal vertex based on the fastest temporal paths which use the temporal vertex. The definition is free from parameters and robust against the change in time scale on which we focus. In addition, we can efficiently compute these centrality values for all temporal vertices. Using the two centrality measures, we reveal that distributions of these centrality values of real-world temporal networks are heterogeneous. For various datasets, we also demonstrate that a majority of the highly central temporal vertices are located within a narrow time window around a particular time. In other words, there is a bottleneck time at which most information sent in the temporal network passes through a small number of temporal vertices, which suggests an important role of these temporal vertices in spreading phenomena. Contribution to the Topical Issue "Temporal Network Theory and Applications", edited by Petter Holme.Supplementary material in the form of one pdf file available from the Journal web page at http://dx.doi.org/10.1140/epjb/e2016-60498-7

  12. Inferring Centrality from Network Snapshots

    Science.gov (United States)

    Shao, Haibin; Mesbahi, Mehran; Li, Dewei; Xi, Yugeng

    2017-01-01

    The topology and dynamics of a complex network shape its functionality. However, the topologies of many large-scale networks are either unavailable or incomplete. Without the explicit knowledge of network topology, we show how the data generated from the network dynamics can be utilised to infer the tempo centrality, which is proposed to quantify the influence of nodes in a consensus network. We show that the tempo centrality can be used to construct an accurate estimate of both the propagation rate of influence exerted on consensus networks and the Kirchhoff index of the underlying graph. Moreover, the tempo centrality also encodes the disturbance rejection of nodes in a consensus network. Our findings provide an approach to infer the performance of a consensus network from its temporal data. PMID:28098166

  13. The exhibition"La France au CERN" was inaugurated by Danièle Hulin, Directrice adjointe Secteur Physique, Chimie, Sciences pour l'Ingénieur (PCSI), Ministère délégué à l'Enseignement supérieur et à la recherche.

    CERN Multimedia

    Patrice Loïez

    2005-01-01

    The exhibition"La France au CERN" was inaugurated by Danièle Hulin, Directrice adjointe Secteur Physique, Chimie, Sciences pour l'Ingénieur (PCSI), Ministère délégué à l'Enseignement supérieur et à la recherche.

  14. 18 January 2011 - Ing. Vittorio Malacalza, ASG Superconductors S.p.A, Italy in the LHC superconducting magnet test hall with Deputy Department Head L. Rossi, in the LHC tunnel at Point 5 and CMS experimental area with Spokesperson G. Tonelli.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    18 January 2011 - Ing. Vittorio Malacalza, ASG Superconductors S.p.A, Italy in the LHC superconducting magnet test hall with Deputy Department Head L. Rossi, in the LHC tunnel at Point 5 and CMS experimental area with Spokesperson G. Tonelli.

  15. CENTRAL MECHANISMS OF ACUPUNCTURE ANALGESIA

    Directory of Open Access Journals (Sweden)

    Eman S. Mansour

    2015-12-01

    Full Text Available Background: Acupuncture is an component of traditional Chinese medicine (TCM that has been used for three thousand years to treat diseases and relieve pain. Pain is found to be the most common reason for people to use acupuncture. Due to recent scientific findings, acupuncture treatment has been accepted worldwide. Numerous trials have been conducted especially in analgesia. The mechanisms of acupuncture analgesia has been widely investigated, however, the underlying mechanism still not clear. This article summarizes the central mechanisms of acupuncture analgesia and reviews recent studies on the topic. Method: We have focused on examining the recent literature on acupuncture analgesia. The central mechanisms of acupuncture analgesia and reviews recent studies on the topic. We focused on the studies related to central mechanisms of acupuncture analgesia from these aspects: (neurophysiology, neurochemistry and neuroanatomy. Result: The result revealed that acupuncture act on various parts of the central nervous system, including the spinal cord, brain stem, cerebral ganglia and cerebral cortex to alleviate pain. The central mechanisms underlying the effects of acupuncture include neurohumors and neurotransmitters, which are involved in analgesia. At spinal level, Spinal opioids, glutamate, norepinephrine and serotonin are the key elements acupuncture-induced analgesia. At brain level, Endogenous opioid peptides, limbic system play essential roles in mediating the analgesia. Conclusion: Acupuncture is an effective approach to pain management. There is good evidence in both experimental and clinical research that supports acupuncture efficacy in management of chronic pain through central nervous system. Acupuncture should be strongly used as a part of pain management plans. This work helps in improving our understanding of the scientific basis underlying acupuncture analgesia.

  16. Central Stars of Planetary Nebulae

    CERN Document Server

    Jones, David

    2016-01-01

    In this brief invited review, I will attempt to summarise some of the key areas of interest in the study of central stars of planetary nebulae which (probably) won't be covered by other speakers' proceedings. The main focus will, inevitably, be on the subject of multiplicity, with special emphasis on recent results regarding triple central star systems as well as wide binaries which avoid a common-envelope phase. Furthermore, in light of the upcoming release of Kepler's Campaign 11 data, I will discuss a few of the prospects from that data including the unique possibility to detect merger products.

  17. Material development in the SI{sub 3}N{sub 4} system using glass encapsulated Hip`ing. Final report, Phase 2: DOE/ORNL Ceramic Technology Project

    Energy Technology Data Exchange (ETDEWEB)

    Corbin, N.D.; Sundberg, G.J.; Siebein, K.N.; Willkens, C.A.; Pujari, V.K.; Rossi, G.A.; Hansen, J.S.; Chang, C.L.; Hammarstrom, J.L.

    1992-04-01

    This report covers a two-year program to develop fully dense Si{sub 3}N{sub 4} matrix SiC whisker composites with enhanced properties over monolithic Si{sub 3}N{sub 4} materials. The primary goal was to develop a composite with a fracture toughness > 10 MPa{radical}m, capable of using high pressure glass encapsulated HIP`ing. Coating methods were developed to apply thin (<150nm) stoichiometric BN layers to SiC whiskers and also to apply a dual coating of SiC over carbon to the whiskers. Fracture toughness of the composites was determined to increase as the quantity of whiskers (or elongated grains) with their axis perpendicular to the crack plane increased. Of the interface compositions evaluated in this effort, carbon was determined to be the most effective for increasing toughness. The highest toughnesses (6.8--7.0 MPa{radical}m) were obtained with uniaxially aligned carbon coated whiskers. There was no evidence of the carbon coating compromising the oxidation resistance of the composites at 1370{degree}C.

  18. Study on Quality Control for the Outsourcing of Acquisitioning and Catalogu-ing Subcontract of University Library%高校图书馆采编业务外包的质量控制研究

    Institute of Scientific and Technical Information of China (English)

    宋月

    2016-01-01

    文章研究了高校图书馆图书采编业务外包的起因,以及采编业务外包对高校图书馆业务的影响,提出有效控制采编业务外包质量的3个途径:正确选择书商、提升外包编目人员素质以及加强编目外包质量的监控,上述措施有效地控制了采编业务外包质量。%In this paper, the cause of the outsourcing of acquisitioning and cataloguing subcontract of university li-brary and its effect on university library were investigated. Three ways to effectively controlling quality of the outsourcing of acquisitioning and cataloguing subcontract was given, that is correct selection of bookseller, upgrad-ing the personnel quality of outsourcing and strengthening the quality control of cataloguing subcontract. All these can effectively control quality of the outsourcing services.

  19. Thinking of the Micro Class Used in the Computer Teach-ing in Universities%将微课应用于高校计算机教学中的几点思考

    Institute of Scientific and Technical Information of China (English)

    谈潘攀

    2014-01-01

    现代社会计算机技术日新月异,高校计算机课程内容需要不断更新,大量的新知识呈几何级数不断地增长,传统的教育技术和手段已经不能适应和满足计算机教学的新需求。为了解决这些问题,本文将微课与高校计算机教学相结合,分析了微课的特点和运用到教学中所带来的问题及解决这些问题的方法。%With the modern computer technology developing rapidly, the contents of computer courses in universities need to be constantly updated and a lot of new knowledge is increasing exponentially. The traditional education technology and method already could not adapt to and meet the new demands of comput-er teaching. In order to solve these problems, this paper combines micro course and computer teaching in universities, and analyzes the characteristics of the micro class and problems in the teach-ing. At the end, this paper gives methods to solve these problems.

  20. Research on the Infiltration of Core Socialist Values Edu-cation into Higher Vocational English Classroom Teach-ing%高职英语课堂教学渗透核心价值观教育研究

    Institute of Scientific and Technical Information of China (English)

    张丽英

    2016-01-01

    Currently, the infiltration of core socialist values edu-cation into higher vocational English course has not been at-tached to much importance in teachers' teaching, students' learn-ing and school support. Through an analysis on the current situa-tion of the infiltration of core socialist values education into higher vocational English classroom teaching, this paper explores feasi-ble methods to infiltrate core socialist values education from the classroom teaching contents and methods of higher vocational English, and proposes the corresponding support that the school should provide.%现阶段高职英语课程渗透核心价值观教育在教师教学、学生学习、学校辅助三个方面都未得到足够的重视和实施,本文通过分析高职英语课堂教学渗透核心价值观教育的现状,从高职英语课堂教学内容和教学方法两个方面探寻渗透核心价值观教育的可执行性方法,并提出学校应给予相应的支持。

  1. Méthodes numériques pour l'ingénieur utilisation de l'outil MATLAB : cours, exercices et problèmes de synthèse corrigés

    CERN Document Server

    Radi, Bouchaïb

    2010-01-01

    L'ouvrage : niveau B (1 UP - Licence). Ce livre est le compagnon de tous ceux qui pratiquent le calcul scientifique. Il rassemble l'essentiel des enseignements des techniques numériques dans les écoles d'ingénieurs et les universités. Mais il est remarquable qu'il ne suppose aucune connaissance préalable en analyse numérique et il est toujours de lecture facile. L'ouvrage expose les différentes méthodes numériques : résolution des systèmes linéaires (directe et itérative), résolution des équations non linéaires, résolution des équations différentielles. Il présente les différents outils d'interpolation, de dérivation et intégrations numériques et d'optimisation sans contraintes. Chaque chapitre débute par des rappels et des définitions illustrés par des exemples numériques variés et des représentations graphiques. Par souci pédagogique, l'outil Matlab est introduit à la fin de chaque chapitre pour familiariser le lecteur avec cet outil. Chaque chapitre est accompagné de diffé...

  2. Research on the Teaching Reform of Exhibition Market-ing Based on the Cultivation of Professional Ability%基于职业能力培养的"会展营销"课程教学改革研究

    Institute of Scientific and Technical Information of China (English)

    张杰丽

    2016-01-01

    "会展营销"课程在学生职业能力培养方面的目标包含市场调查能力、商务沟通能力、营销策划能力、销售管理能力和客户服务能力;在此基础上提出了"会展营销"课程的教学改革应从课程内容的优化、教学方法的创新、实践教学内涵的提升、考核评价体系的创新等四个维度展开的建议.%In the cultivation of students' professional abilities, ex-hibition marketing aims at cultivating students' market research ability, business communication ability, marketing planning abil-ity, sales management ability and customer service ability. Based on the above objectives, this paper proposes that the teaching re-form of exhibition marketing should be implemented from course content optimization, teaching method innovation, practice teach-ing improvement and evaluation system innovation.

  3. 浅谈启发式教学法在物理光学课堂教学中的应用%A Brief Discussion on the Application of Heuristic Teach-ing Method in Physical Optics Classroom Teaching

    Institute of Scientific and Technical Information of China (English)

    曲芳; 于意仲; 倪晓昌; 徐丽娟; 孙鸿波; 芦宇; 孔维敬

    2015-01-01

    本文探讨了启发式教学法在课程引入、建立感性认识、理性推导、应用提高以及思考练习等教学环节的应用。利用启发性的提问,引导学生思考,使学生自主学习,在解答问题的过程中,学会知识、掌握技能和开拓思维。启发式教学法能充分调动学生学习的积极性,达到良好的教学效果。%This paper explores the application of heuristic teach-ing method in course introduction, building perceptual cog-nizance, rational deduction, application improvement, thinking and practice. We can lead students' thinking and self-study by using the heuristic questions, let them master the knowledge and skills, and expand their thinking when resolving the questions. Heuristic teaching method can fully mobilize students' study ac-tivity and help achieve the desired teaching effect.

  4. 提升养老院老人幸福感的对策研究%Research on Countermeasures of Improving the Well-be-ing of the Elderly in Nursing Homes

    Institute of Scientific and Technical Information of China (English)

    黄建岚; 周继武

    2014-01-01

    Aging has become a global problem, and along with the coming of the aging society in China, more and more elderly peo-ple enters nursing homes to spend their remaining years in com-fort. Factors affecting the well-being of the elderly in nursing homes are mainly as follows, the ideas of spending their remain-ing years and the reasons of staying in nursing homes, personal characters and adaptability, hardware conditions and service qualities, family care and social care, and so on. The improve-ment of the well-being of the elderly in nursing homes needs the joint efforts of nursing homes, the elderly, families, the society and the government.%老龄化已成为一个全球性的问题,随着中国老龄化社会的到来,越来越多的老年人进入养老院养老。影响养老院老人幸福感的因素有养老观念与入住原因、个人性格与适应能力、硬件条件与服务质量、家人关心与社会关爱等。提升养老院老人的幸福感需要养老院、老人、家庭、社会、政府的共同努力。

  5. Central Libraries in Uncertain Times.

    Science.gov (United States)

    Kenney, Brian J.

    2001-01-01

    Discusses security and safety issues for public libraries, especially high-profile central facilities, in light of the September 11 terrorist attacks. Highlights include inspecting bags as patrons enter as well as exit; the need for security guidelines for any type of disaster or emergency; building design; and the importance of communication.…

  6. New Economy, Old Central Banks?

    NARCIS (Netherlands)

    Berk, Jan Marc

    2002-01-01

    Proponents of the so-called New Economy claim that it entails a structural change of the economy. Such a change, in turn, would require the central bank to rethink its monetary policy to the extent that traditional relationships between inf1ation and economic growth are no longer valid. But such a r

  7. Vulnerability in north- central Vietnam

    DEFF Research Database (Denmark)

    Casse, Thorkil; Milhøj, Anders; Nguyen, Thao Phuong

    2015-01-01

    This article examines changes in livelihood strategies in response to flooding. It does so on the basis of a household survey which was undertaken in three provinces in north central Vietnam. All households in the survey were regularly affected by flooding, but only poor households experience...

  8. Water Governance in Central Asia

    NARCIS (Netherlands)

    Djanibekov, Nodir; Assche, Van Kristof; Valentinov, Vladislav

    2016-01-01

    We develop a social systems theory perspective on Central Asian post-Socialist transition, placing particular emphasis on the coordination problems in transboundary water governance. The extensive Soviet water-energy infrastructure around the Amudarya and Syrdarya rivers required coordination, bu

  9. The Centrality of Ethical Leadership

    Science.gov (United States)

    Ehrich, Lisa C.; Harris, Jessica; Klenowski, Val; Smeed, Judy; Spina, Nerida

    2015-01-01

    Purpose: The central argument in this paper is that ethical school leadership is imperative in a context of increasing performance-driven accountability. The purpose of this paper is to focus on school principals' perceptions of how they understand ethical leadership and how they lead the ethical use of data. Design/Methodology/Approach: This…

  10. Learning and the central bank

    OpenAIRE

    Charles T. Carlstrom; Timothy S. Fuerst

    2001-01-01

    It is well known that sunspot equilibria may arise under an interest-rate operating procedure in which the central bank varies the nominal rate with movements in future inflation (a forward-looking Taylor rule). This paper demonstrates that these sunspot equilibria may be learnable in the sense of E-stability.

  11. The MEANING multilingual central repository

    NARCIS (Netherlands)

    Atserias, J.; Villarejo, L.; Rigau, G.; Agirre, E.; Carroll, J.; Magnini, B.; Vossen, P.

    2004-01-01

    This paper describes the first version of the Multilingual Central Repository, a lexical knowledge base developed in the framework of the MEANING project. Currently the MCR integrates into the EuroWordNet framework five local wordnets (including four versions of the English WordNet from Princeton),

  12. Copycats of the Central Himalayas

    NARCIS (Netherlands)

    P.A. Arora (Payal)

    2009-01-01

    textabstractThis case study highlights practices of a rarely documented group of neo-users of the Internet or newbies from Central Himalayas, serving as a catalyst for delving deeply into the act of ‘plagiarism’ in online learning By looking at such ‘learning’ practices away from schools, namely at

  13. Reduced central blood volume in cirrhosis

    DEFF Research Database (Denmark)

    Henriksen, Jens Henrik; Bendtsen, Flemming; Sørensen, T I

    1989-01-01

    for measuring the central blood volume. We have developed a method that enables us to determine directly the central blood volume, i.e., the blood volume in the heart cavities, lungs, and central arterial tree. In 60 patients with cirrhosis and 16 control subjects the central blood volume was assessed according...

  14. 27 CFR 9.75 - Central Coast.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Central Coast. 9.75... Central Coast. (a) Name. The name of the viticultural area described in this section is “Central Coast.” (b) Approved maps. The approved maps for determining the boundary of the Central Coast...

  15. All aboard the Safety Train(ing)!

    CERN Multimedia

    Rosaria Marraffino

    2015-01-01

    Would you like to influence CERN’s safety courses? Do you want to help build better training courses? If your answer is yes to one or both of these questions: now is the time! The Safety Training section is looking for volunteers from the whole CERN community to test new courses before they go online for all members of the personnel.    The Safety Training section is redesigning the CERN e-learning package in order to adopt a more educational approach and to make the courses a more enjoyable experience. The section is now calling for volunteers. “We know we can do much more with testers’ help and feedback,” explains Christoph Balle, Safety Training section leader. “By having the end users actively involved in the process, we’ll achieve our goal of communicating safety in the best possible way. As the volunteers will play an active role in the development of the courses, they will be providing a service to the whole community.&am...

  16. DAM-ing the Digital Flood

    Science.gov (United States)

    Raths, David

    2008-01-01

    With the widespread digitization of art, photography, and music, plus the introduction of streaming video, many colleges and universities are realizing that they must develop or purchase systems to preserve their school's digitized objects; that they must create searchable databases so that researchers can find and share copies of digital files;…

  17. Hageri alustas oreli taastamisega / Inge Põlma

    Index Scriptorium Estoniae

    Põlma, Inge

    2009-01-01

    1851. aastal eesti orelimeistri Carl Tantoni valmistatud ja 1892. aastal Gustav Terkmanni poolt kohendatud Hageri Lambertuse kiriku oreli restaureerimisest, ekspertiisi tegi rootsi organist Göran Grahn

  18. Ravimid, risk, raha & tervis / Inge Pitsner

    Index Scriptorium Estoniae

    Pitsner, Inge

    2008-01-01

    Ravimifirma Roche Eesti OÜ tegevjuht Kadri Mägi selgitab ravimiäri toimemehhanisme ning põhjuseid, miks ravimitööstus on riskantne ja kallis valdkond. Lisa: Mis on farmakoökonoomika?; Roche Eesti kontor

  19. Queer, Queering, and Queer(ing) Futurity

    Institute of Scientific and Technical Information of China (English)

    何磊

    2015-01-01

    <正>The essay tries to reflect on"queer"and(its)"future/futurity"through a perspective from"outside."The socalled"perspective from outside"first implies that,it is a kind of thinking provoked by the encounter of different cultures,languages,views,and horizons.Also,the"outside"reflection is mainly inspired by the experience of reading and translating

  20. Ühiskonnakriitika kinos / Inge Pitsner

    Index Scriptorium Estoniae

    Pitsner, Inge

    2004-01-01

    Baltimaade dokfilmiprogramm "Subjektiivne kaamera", mis tutvustab uuemaid provokatiivseid, poleemikat tekitavaid autorikeskseid filme. See on osa Tallinnas toimuvast 8. Läänemere Dokumentalistika Foorumist

  1. CommuniCAT(E)ing with NCTE

    Science.gov (United States)

    Younglove, Bill

    2011-01-01

    This article features the California Association of Teachers of English (CATE) Board, a state affiliate of the National Council of Teachers of English (NCTE), whose members en(and de)plane traditionally four times a year for weekend board meetings. An important and influential state affiliate, CATE serves California teachers and students as well…

  2. An Ap"peel"ing Activity

    Science.gov (United States)

    Urich, Joshua A.; Sasse, Elizabeth A.

    2011-01-01

    This article describes a hands-on mathematics activity wherein students peel oranges to explore the surface area and volume of a sphere. This activity encourages students to make conjectures and hold mathematical discussions with both their peers and their teacher. Moreover, students develop formulas for the surface area and volume of a sphere…

  3. EMERGE-ing from the Shadows

    Science.gov (United States)

    Grier, Terry B.

    2014-01-01

    Houston school officials noticed their best performing low-income students weren't applying to Ivy League and selective colleges. In response, they created EMERGE, a program that develops and guides talented youths toward a top-college path.

  4. 点击go+v-ing

    Institute of Scientific and Technical Information of China (English)

    杨继龙

    2002-01-01

    在初中教材中,“go+v-ing”是一个比较常见的结构。“go+v-ing”主要表示“to go somewhere in order to do sth.”由于这一结构出现的频率较高,其表意功能已日趋引申。现就初中阶段“go+v-ing”的用法总结归纳如下:

  5. Eesti lastekodulaps kinkis Norra kuningannale ingli

    Index Scriptorium Estoniae

    2004-01-01

    Norra kuninganna Sonja ning peaminister Kjell Magne Bondevik võõrustasid lastekodukasvandikku Marina Shirabokovat koos Norra filantroobi Solveig Bergslandiga, kes on seitse aastat toetanud puudust kannatavaid Eesti lapsi

  6. Idea juht eitas maksupettust / Inge Rumessen

    Index Scriptorium Estoniae

    Rumessen, Inge

    2002-01-01

    Reklaamiagentuuri Idea juht Mark Eikner eitas kohtuistungil seost mitmemiljonilise maksupettuse skeemiga möödunud kohalike valimiste ajal. Kohtuprotsess Meelis Siidirätsepa üle, kes OÜ Rescue juhina jättis tasumata 1,5 milj. krooni käibemaksu

  7. TRACE-ing human trafficking : Project Findings

    NARCIS (Netherlands)

    Rijken, Conny; Pijnenburg, Annick

    2016-01-01

    Human trafficking is one of the largest criminal enterprises in the world. It is a multi-billion-dollar crime of global scale. This is because human trafficking as a criminal enterprise continues to evolve as a high profit-low risk business for perpetrators and challenges policy makers, law enforcem

  8. Central venous line complications and tip detection

    OpenAIRE

    Ameneh Rezaee Gheshlaghi; Hamid Zamani Moghadam Dolu; Elham Pishbin; Maryam Salehi

    2015-01-01

    Central venous line is one of a creative instrument that saves human’s life in critical medical situation. Central venous line access is frequently involved in the disease management. It is used for rapid fluid therapy, transvenous pacemakers, infusion of some medications, hemodialysis or plasmapheresis and etc. Most of the emergency departments have some staffs that are trained for central venous line insertion but related complications occur during central venous line placement.Central veno...

  9. Is Central Asia really exsiccating?

    Science.gov (United States)

    Aizen, V. B.; Aizen, E. M.; Surazakov, A. B.

    2008-12-01

    At the end of 20th and the beginning of 21st century central Asia oases suffered from serious drought caused lack of water for agriculture, economy growth and population increase. However, people of this region always experienced lack of water for irrigation and fought a war over the rights to control river streams. The drying up of central Asian rivers is not a new phenomenon according to the ancient manuscripts. Thus, lets see about what has happened with the past century climate and water resources of central Asia using the long-term observational data. We analyzed data from more than 200 meteorological stations and stream gauges over the central Asia in elevation range from 25 m. b.s.l. to 4,000 m. a.s.l. to understand the last 100 years variability in climate and water resources, examining changes in the extreme and mean monthly air temperatures, precipitation and river runoff. The evaluation of seasonal snow and glacier's covered areas between 1970th and 2007th in central Asia derived from AVHRR, MODIS, Hexagon KH-9, Landsat ETM and ASTER data exhibit 15% reduction of the seasonal snow covered area and 10.1% of the glacier area. It has been found that during last twenty years the duration of snowmelt, from the date of maximum snow cover to date of its disappearance, reduced by 30 days and in 2007 was equal to 138 days in the central Asian mountains. The decrease of seasonal snow cover is not a linear process. The further decrease may be accelerated due to increase of rainfall instead of snowfall in early spring months at high elevations, and consequently a lesser heat expenditure for the snowmelt. The growth in summer air temperatures, especially observable since the 1970th, accompanied by increase of evapotranspiration and precipitation, notably in summer and autumn, and at high elevations over 3,000 m, and at the western peripheral mountain ridges. Average difference in the means of annual air temperatures for the two thirty-year periods before and after

  10. The Central Valley Hydrologic Model

    Science.gov (United States)

    Faunt, C.; Belitz, K.; Hanson, R. T.

    2009-12-01

    Historically, California’s Central Valley has been one of the most productive agricultural regions in the world. The Central Valley also is rapidly becoming an important area for California’s expanding urban population. In response to this competition for water, a number of water-related issues have gained prominence: conjunctive use, artificial recharge, hydrologic implications of land-use change, subsidence, and effects of climate variability. To provide information to stakeholders addressing these issues, the USGS made a detailed assessment of the Central Valley aquifer system that includes the present status of water resources and how these resources have changed over time. The principal product of this assessment is a tool, referred to as the Central Valley Hydrologic Model (CVHM), that simulates surface-water flows, groundwater flows, and land subsidence in response to stresses from human uses and from climate variability throughout the entire Central Valley. The CVHM utilizes MODFLOW combined with a new tool called “Farm Process” to simulate groundwater and surface-water flow, irrigated agriculture, land subsidence, and other key processes in the Central Valley on a monthly basis. This model was discretized horizontally into 20,000 1-mi2 cells and vertically into 10 layers ranging in thickness from 50 feet at the land surface to 750 feet at depth. A texture model constructed by using data from more than 8,500 drillers’ logs was used to estimate hydraulic properties. Unmetered pumpage and surface-water deliveries for 21 water-balance regions were simulated with the Farm Process. Model results indicate that human activities, predominately surface-water deliveries and groundwater pumping for irrigated agriculture, have dramatically influenced the hydrology of the Central Valley. These human activities have increased flow though the aquifer system by about a factor of six compared to pre-development conditions. The simulated hydrology reflects spatial

  11. Centrality in Interconnected Multilayer Networks

    CERN Document Server

    De Domenico, Manlio; Omodei, Elisa; Gómez, Sergio; Arenas, Alex

    2013-01-01

    Real-world complex systems exhibit multiple levels of relationships. In many cases, they require to be modeled by interconnected multilayer networks, characterizing interactions on several levels simultaneously. It is of crucial importance in many fields, from economics to biology, from urban planning to social sciences, to identify the most (or the less) influent nodes in a network. However, defining the centrality of actors in an interconnected structure is not trivial. In this paper, we capitalize on the tensorial formalism, recently proposed to characterize and investigate this kind of complex topologies, to show how several centrality measures -- well-known in the case of standard ("monoplex") networks -- can be extended naturally to the realm of interconnected multiplexes. We consider diagnostics widely used in different fields, e.g., computer science, biology, communication and social sciences, to cite only some of them. We show, both theoretically and numerically, that using the weighted monoplex obta...

  12. Centralized versus Decentralized Infrastructure Networks

    CERN Document Server

    Hines, Paul D H; Schläpfer, Markus

    2015-01-01

    While many large infrastructure networks, such as power, water, and natural gas systems, have similar physical properties governing flows, these systems tend to have distinctly different sizes and topological structures. This paper seeks to understand how these different size-scales and topological features can emerge from relatively simple design principles. Specifically, we seek to describe the conditions under which it is optimal to build decentralized network infrastructures, such as a microgrid, rather than centralized ones, such as a large high-voltage power system. While our method is simple it is useful in explaining why sometimes, but not always, it is economical to build large, interconnected networks and in other cases it is preferable to use smaller, distributed systems. The results indicate that there is not a single set of infrastructure cost conditions under which optimally-designed networks will have highly centralized architectures. Instead, as costs increase we find that average network size...

  13. A centralized audio presentation manager

    Energy Technology Data Exchange (ETDEWEB)

    Papp, A.L. III; Blattner, M.M.

    1994-05-16

    The centralized audio presentation manager addresses the problems which occur when multiple programs running simultaneously attempt to use the audio output of a computer system. Time dependence of sound means that certain auditory messages must be scheduled simultaneously, which can lead to perceptual problems due to psychoacoustic phenomena. Furthermore, the combination of speech and nonspeech audio is examined; each presents its own problems of perceptibility in an acoustic environment composed of multiple auditory streams. The centralized audio presentation manager receives abstract parameterized message requests from the currently running programs, and attempts to create and present a sonic representation in the most perceptible manner through the use of a theoretically and empirically designed rule set.

  14. The CDF Central Analysis Farm

    Energy Technology Data Exchange (ETDEWEB)

    Kim, T.H.; /MIT; Neubauer, M.; /UC, San Diego; Sfiligoi, I.; /Frascati; Weems, L.; /Fermilab; Wurthwein, F.; /UC, San Diego

    2004-01-01

    With Run II of the Fermilab Tevatron well underway, many computing challenges inherent to analyzing large volumes of data produced in particle physics research need to be met. We present the computing model within CDF designed to address the physics needs of the collaboration. Particular emphasis is placed on current development of a large O(1000) processor PC cluster at Fermilab serving as the Central Analysis Farm for CDF. Future plans leading toward distributed computing and GRID within CDF are also discussed.

  15. Central Nucleon-Nucleon Potential

    Science.gov (United States)

    Robilotta, M. R.

    2001-12-01

    The outer region of the NN interactions is dominated by the one pion exchange potential (OPEP), followed by the two-pion exchange potential (TPEP). Chiral calculations of the TPEP have been performed using either heavy baryon1 (HB) or relativistic2 perturbation theories. We compare the predictions from these two approaches for the dominant central interaction and show that they fail to agree by 25% ...

  16. Celtic Sites of Central Iberia

    Science.gov (United States)

    Pérez Gutiérrez, Manuel

    This chapter concerns the astronomy practiced by Celtic peoples in some parts of central Iberia, specifically the Vetton and Celtiberian peoples, inhabitants of the so-called Late Iron Age. The construction of some elements of religion or worship was perfectly determined by geometry, topography, and especially astronomy, because their spatial orientation occurs in locations of great interest for maintaining the local calendar. The maintenance of this calendar was probably the primary objective of some of the elements studied.

  17. Information from the central stores

    CERN Multimedia

    GS Department

    2010-01-01

    All items sold in the CERN shop (Bldg. 33) are now available in the central stores (Bldg. 73) and can be purchased on-line via EDH “Material Request” or at the “Emergency Desk” of the stores on the ground floor of Bldg. 73. These items are visible in the CERN catalogue under the “SCEM” codes beginning with 92. Department of General Infrastructure Services (GS) GS-SEM Group

  18. Central Asia, Physical Geography Handbook.

    Science.gov (United States)

    2007-11-02

    over 2,000 m) is not applicable to Central Asia, partly because the general hypsometric level of this region is high and unstable, as a consequence of...organic fossils in them, gastropods have been discovered. On the main territory of the Tarim massif, which evidently represented a weakly elevated...places seams of gypsum and rock salt, and, in a part to the west of the town of Aksu, also a bed of gray limestone with small fresh- water gastropods

  19. Central charges in regular mechanics

    CERN Document Server

    Cabo-Montes de Oca, Alejandro; Villanueva, V M

    1997-01-01

    We consider the algebra associated to a group of transformations which are symmetries of a regular mechanical system (i.e. system free of constraints). For time dependent coordinate transformations we show that a central extension may appear at the classical level which is coordinate and momentum independent. A cochain formalism naturally arises in the argument and extends the usual configuration space cochain concepts to phase space.

  20. Impacts des TIC sur l’enseignement et l’apprentissage des conceptions relatives au champ électrostatique en classes préparatoires aux grandes écoles d’ingénieurs (CPGE

    Directory of Open Access Journals (Sweden)

    Abdelaziz Bouchaib

    2011-01-01

    Full Text Available Cet article décrit une séquence d’enseignement au cours de laquelle nous avons expérimenté les ressources numériques du site Université en Ligne (UeL, relatives au module d’électrostatique, avec des étudiants de la première année des classes préparatoires aux grandes écoles d’ingénieurs. Nous rappelons brièvement les difficultés conceptuelles rencontrées chez les étudiants de premier cycle universitaire dans le domaine de l’électrostatique. La description de la séquence, expérimentée durant trois années consécutives en deux versions, est suivie d’une analyse des perceptions des étudiants à propos du site UeL. Cette analyse montre que les étudiants sont largement satisfaits du contenu, de la clarté et de la motivation que le site procure dans l’apprentissage. Nous étudions ensuite l’apport de l’UeL sur les conceptions des étudiants participant à l’expérimentation à propos du champ électrostatique créé par une charge ponctuelle et du principe de superposition des champs créés par deux charges ponctuelles. Les résultats montrent que, lorsque les ressources de l’UeL sont intégrées en situation d’auto-apprentissage accompagné par un enseignant tuteur, elles permettent une bonne appropriation de ces concepts et une meilleure interprétation des situations utilisées comme instrument d’évaluation.

  1. Discussion on the construction of MOOC course in obstetric and gynecological nursing teach-ing%妇产科护理学课程慕课建设探讨

    Institute of Scientific and Technical Information of China (English)

    廖碧珍

    2015-01-01

    重庆医科大学为适应信息化教学新要求,以培养具有良好评判思维能力及岗位胜任力的新型护理人才为目标,以课程建设为突破口,探索妇产科护理学课程慕课建设与应用。通过慕课网络平台为学生提供丰富教学资源,让学生课前完成自主学习、互动讨论、试题出错率检测与反馈,为教师设计翻转课堂教学提供依据。利用慕课实施混合教学,逐步培养学生自主学习能力。%To meet the new requirements of modern information education, and to achieve the goal of developing a new type of nursing talents with good judgment thinking ability and post compe-tency, Chongqing Medical University explored the construction and application of nursing courses in obstetrics and Gynecology. By means of MOOC network platform, we provided students with rich teach-ing resources, so that students could complete their own learning, interactive discussion, examination questions and feedback, to provide the basis for teachers designing the teaching of flipped classroom. We also used the MOOC class to implement the mixed teaching, and gradually develop students' au-tonomous learning ability.

  2. Central hypersensitivity in chronic musculoskeletal pain.

    Science.gov (United States)

    Curatolo, Michele; Arendt-Nielsen, Lars

    2015-05-01

    Clinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity.

  3. Central hypersensitivity in chronic musculoskeletal pain

    DEFF Research Database (Denmark)

    Curatolo, Michele; Arendt-Nielsen, Lars

    2015-01-01

    Clinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold...... standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central...... level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity....

  4. Ocorrência e aspectos ecológicos de metazoários parasitos de peixes do Lago do Parque do Ingá, Maringá, Estado do Paraná - DOI: 10.4025/actascibiolsci.v29i3.507 Occurrence and ecological aspects of the metazoan fish parasites from Ingá lake, Maringá, Paraná State - DOI: 10.4025/actascibiolsci.v29i3.507

    Directory of Open Access Journals (Sweden)

    Marion Haruko Machado

    2007-12-01

    Full Text Available Nenhum estudo de peixes e parasitos foi realizado, até o momento, no Lago do Parque do Ingá que sofre influências antrópicas desde seu represamento, em 1970. Este trabalho analisou alguns aspectos ecológicos dos parasitos metazoários dos peixes deste lago. Dos peixes analisados, (69,5% estavam parasitados por pelo menos uma espécie de parasito. Foram encontrados 1.372 parasitos pertencentes à Nematoda (larvas e Platyhelminthes (Monogenea e Cestoda, sendo estes os mais prevalentes e numerosos. O encontro de larvas de cestóides em Tilapia rendalli e Oreochromis niloticus confirma a importância destas espécies como participantes de níveis tróficos intermediários. A maior abundância de T. rendalli e O. niloticus, no local, pode ser um fator determinante no recrutamento de parasitos. O parasito aproveita-se das espécies de hospedeiros mais abundantes para garantir o desenvolvimento de seu ciclo de vida e também por serem os mais disponíveis à predação pelas aves piscívoras ali presentes, o que torna o local de grande importância para a sustentação do ciclo de vida desses parasitos. A baixa diversidade de endoparasitos coletados pode ser justificada pela presença de metais pesados – Cu e Pb – no sedimento, o que deve estar interferindo no desenvolvimento dos invertebrados, possíveis hospedeiros intermediários.Ingá lake was dammed in 1970 and, since then, no study on fish and parasites had been done, but it has suffered anthropic influences. This study analyzed some ecological aspects of the metazoan parasites form this lake. From analyzed fish, 69.5% had at least one species of parasite. Among them, 1.372 parasites were found, prevailing Nematoda (larvae and Platyhelminthes (Monogenea and Cestoda. The discovery of cestode larvae in Tilapia rendalli and Oreochromis nitolicus confirms the importance of these species as participants of intermediate trophic levels. The great number of Tilapia rendalli and Oreochromis

  5. Unlocking India’s Strategic Potential in Central Asia

    Science.gov (United States)

    2015-10-01

    Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law , no person shall be subject...lingering suspicion and poten- tially explosive conflict between the two countries, which are only starting to learn the ropes of project- ing

  6. CHINA AND ENERGY SECURITY IN CENTRAL ASIA

    OpenAIRE

    Guang, Pan

    2007-01-01

    This paper is divided into three parts: China’s energy policy and energy development strategy; Central Asia’s significance for China’s overseas energy development strategy; and Central Asia’s energy security and energy development.

  7. [Historical demography in the Central American isthmus].

    Science.gov (United States)

    Perez Brignoli, H

    1980-01-01

    The author reviews and evaluates sources of information on the demographic history of Central America. Past and present administrative, state, ecclesiastical, and genealogical sources are examined, and recent studies of various Central American countries are cited. A bibliography is provided

  8. Cergop-2, A Multipurpose and Interdisciplinary Sensor Array For Environmental Research In Central Europe

    Science.gov (United States)

    Pesec, P.

    The project CERGOP-2 (second phase of the Central Europe Regional Geodynamics Project)was initiated 1998, as a successor of CERGOP 1993/1998. During the follow- ing 3 years a new concept was worked out which finally was submitted for EU-support under the Sub-Programme Environment and Sustainable Development (5. FP) Octo- ber 2001. In the meanwhile the proposal received a "go" which implies a ranking in the final set of proposals forseen for eventual financial support. 14 contractors out of 13 countries contributed to the formulation of the proposal, the planned actions comprize the consolidation of the GPS-network,which covers about 15 % of the European territory, the final aim being the establishment of a velocity field which allows for the derivation of strain-fields and the monitoring of energy transfer for geodynamic studies and hazard mitigation. This paper will give an overview of the required actions and the expected results, paying special attention to near real-time information and regional geodynamic inves- tigations of seismic active regions.

  9. Scénarisation Pédagogique et Ingénierie Dirigé par les Modèles Cadre d'étude pour la définition de langages et environnements-outils de scénarisation pédagogique spécifiques à des domaines

    OpenAIRE

    Laforcade, Pierre; Barré, Vincent; Zendagui, Boubekeur

    2007-01-01

    International audience; Ces dernières années, l'intérêt pour l'Ingénierie Dirigée par les Modèles en tant que cadre théorique et pratique lié à divers domaines de l'ingénierie des EIAH ou à des domaines connexes s'est accru. Dans cet article, nous montrerons qu'appliquer ce cadre dans un contexte de scénarisation est intéressant et permet de mieux guider cette activité. Après avoir évoqué les écueils et différences liés à ce nouveau contexte, nous proposerons une catégorisation des scénarios ...

  10. Puente del Pedrido, tramo central

    Directory of Open Access Journals (Sweden)

    Torroja, Eduardo

    1962-02-01

    Full Text Available Planteada la necesidad de proceder a la ejecución del tramo central del puente en el Pasaje del Pedrido sobre la ría de Betanzos, y encontrándonos con que las armaduras para el mismo, que ya estaban acopiadas a pie de obra antes de la guerra, estaban totalmente no tuvimos inconveniente, puesto que habían de adquirirse de nuevo, en introducir algunas ligeras modificaciones sobre el proyecto anterior, a fin de reducir en lo posible el coste de la obra.

  11. Nonlocally Centralized Simultaneous Sparse Coding

    Institute of Scientific and Technical Information of China (English)

    雷阳; 宋占杰

    2016-01-01

    The concept of structured sparse coding noise is introduced to exploit the spatial correlations and nonlo-cal constraint of the local structure. Then the model of nonlocally centralized simultaneous sparse coding(NC-SSC)is proposed for reconstructing the original image, and an algorithm is proposed to transform the simultaneous sparse coding into reweighted low-rank approximation. Experimental results on image denoisng, deblurring and super-resolution demonstrate the advantage of the proposed NC-SSC method over the state-of-the-art image resto-ration methods.

  12. Inverting the central limit theorem

    CERN Document Server

    Navascues, Miguel; Villanueva, Ignacio

    2011-01-01

    The central limit theorem states that the sum of N independently distributed n-tuples of real variables (subject to appropriate normalization) tends to a multivariate gaussian distribution for large N. Here we propose to invert this argument: given a set of n correlated gaussian variables, we try to infer information about the structure of the discrete microscopic probability distributions whose convolution generated such a macroscopic behavior. The techniques developed along the article are applied to prove that the classical description of certain macroscopic optical experiments is infinitely more complex than the quantum one.

  13. Kalmanovitz y la banca central.

    OpenAIRE

    Maya M, Guillermo

    2011-01-01

    Salomón Kalmanovitz, Codirector del Banco de la República (B de la R) hasta enero de 2005, uno de los economistas colombianos más brillantes, publicó un libro titulado Ensayos sobre Banca Central, Comportamiento, Independencia e Historia (Norma, 2003). Si los estudiantes de economía de los años 70 y 80 estudiaron a un Kalmanovitz marxista, los estudiantes de hoy estudian a un economista ortodoxo y liberal, igualmente brillante. Kalmanovitz es un partidario de la independencia de la BC para la...

  14. Distributed trace using central performance counter memory

    Science.gov (United States)

    Satterfield, David L.; Sexton, James C.

    2013-01-22

    A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.

  15. Capitalizing Central Banks: A Net Worth Approach

    OpenAIRE

    Alain Ize

    2005-01-01

    This paper provides a simple, quantitative, net worth-based, approach to assessing the need for central bank capital. It derives a concept of "core capital" (a function of the central bank's operating expenditures and the carrying cost of its international reserves) as the minimum capital needed by a central bank to ensure the credibility of its inflation target. The approach is illustrated with the published accounts of three loss-making central banks and selected accounting entries for a br...

  16. The European Central Bank and the Eurosystem

    OpenAIRE

    Carol C. Bertaut

    2002-01-01

    The Eurosystem comprises the European Central Bank at its center as well as the national central banks of the twelve countries currently participating in monetary union. The European Central Bank was established in July 1998, six months before the beginning of Stage Three of economic and monetary union. Although decisions regarding monetary policy are made centrally by the Governing Council of the Eurosystem, the operational aspects of monetary policy-including open market operations, adminis...

  17. Legal and actual central bank independence

    OpenAIRE

    Artha, I.K.D.S.; de Haan, J.

    2010-01-01

    Indicators of central bank independence (CBI) based on the interpretation central bank laws in place may not capture the actual independence of the central bank. This paper develops an indicator of actual independence of the Bank Indonesia (BI), the central bank of Indonesia, for the period 1953-2008 and compares it with a new legal CBI indicator based on Cukierman (1992). The indicator of actual independence captures institutional and economic factors that affect CBI. We find that before 199...

  18. From Dungans to Xinyimin: China, Chinese Migration and the Changing Sociopolitical Fabric of Central Asian Republics

    Directory of Open Access Journals (Sweden)

    Emile Kok-Kheng Yeoh

    2015-08-01

    Full Text Available This paper looks at the issue of ethnic identity of the Dungans – descendants of early Chinese migrants in Central Asia – and its change and preservation in the context of the fragile social fabric of the Central Asian states that were born from the shadow of the now-defunct Soviet Union, the arduous processes of nation-building plagued by often violent, competing emergent nationalisms as well as political and economic turbulence, and the impact brought by the emergence of the xinyimin (Chinese new migrants. These Chinese-speaking Dungans staying in compact communities mostly in Kazakhstan, Kyrgyzstan and Uzbekistan are descendants of political and war refugees from China’s provinces of Shaanxi and Gansu who moved across the border into the territory of Czarist Russia in the later part of the nineteenth century after the crushing of the Northwest Uprising by the Imperial Ch’ing (the Manchu dynasty army which bordered on genocide and ethnic cleansing. This paper analyses how a new ethnic identity has since emerged due partly to the geographical isolation imposed by the formidable natural barrier of the Tianshan (“Heavenly Mountains” However, their Chinese language in the form of a mixture of the Shaanxi and Gansu regionalects, remarkably written today not in Chinese characters but in the Cyrillic alphabet, and Chinese traditions of the Shaanxi and Gansu varieties have been fiercely preserved through the generations until today, including nineteenth-century vocabulary and traditions which are no longer found in modern China, due both to the cohesiveness of communal life and an aversion to marriage outside the community. After analysing the community’s dilemmas of identity preservation and identity creation, this paper then proceeds to look at the impact of the disintegration of the Soviet Union in 1991 resulting in the birth of the post-Soviet independent Central Asian republics, and the influx of the xinyimin from China since the

  19. Central Pontine Myelinolysis: Report of Four Cases

    Directory of Open Access Journals (Sweden)

    Handan Akar

    2010-09-01

    Full Text Available Central pontine myelinolysis is a neurological disorder characterized by loss of myelin in the central pons as well as in the other parts of the brain like basal ganglia, lateral geniculate bodies, external and internal capsules, and cerebellum. We report the clinical and radiological findings of three patients with central pontine myelinolysis and one patient with both pontine and extrapontine myelinolysis.

  20. Central bank independence and inflation revisited

    NARCIS (Netherlands)

    Klomp, Jeroen; de Haan, Jakob

    2010-01-01

    We re-examine the relationship between central bank independence (CBI), proxied by the central bank governor's turnover rate and an indicator based on central bank laws in place, and inflation using a random coefficient model with the Hildreth-Houck estimator for more than 100 countries in the perio

  1. "Christofest" New Yorgi Central Parkis / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2004-01-01

    12. II 2005. a. avatakse Christo ja Jeanne-Claude'i keskkonnainstallatsioon "The Gates" New Yorgi Central Parkis. Paralleelselt toimub Metropolitan Muuseumis näitus "Christo and Jeanne-Claude : The Gates, Central Park, New York", kus eksponeeritakse Central Parki installatsiooni ettevalmistavaid materjale: joonistusi, diagramme, fotosid jne

  2. Different root fil ing material and method of row piles,crown Fang Wei leakage after preparatory research status at home and abroad%不同根充材料及方法行桩道预备后冠方微渗漏的国内外研究现状

    Institute of Scientific and Technical Information of China (English)

    杨光; 董青; 张海龙; 苏哲君; 王敬; 张兴乐

    2014-01-01

    根管治疗的目的是严密充填根管以消除根管死腔,评价其成败的关键因素是根管系统的三维严密充填,因而根管充填后存在的微渗漏是导致充填失败的重要原因。本文就不同根充材料及方法行桩道预备后冠方微渗漏的国内外研究现状做一综述。%The purpose of root canal therapy is closely root canal to eliminate the root canal fil ing the die cavity,evaluate its success or failure of the key factors is the three-dimensional close packing of root canal system,and after root canal fil ing of micro leakage is a main reason for the failure of packing.In this paper,the dif erent root fil ing material and preparation method row pile after crown Fang Wei leakage of domestic and foreign research present situation.

  3. Precipitation chemistry in central Amazonia

    Science.gov (United States)

    Andreae, M. O.; Talbot, R. W.; Berresheim, H.; Beecher, K. M.

    1990-01-01

    Rain samples from three sites in central Amazonia were collected over a period of 6 weeks during the 1987 wet season and analyzed for ionic species and dissolved organic carbon. A continuous record of precipitation chemistry and amount was obtained at two of these sites, which were free from local or regional pollution, for a time period of over 1 month. The volume-weighted mean concentrations of most species were found to be about a factor of 5 lower during the wet season compared with previous results from the dry season. Only sodium, potassium, and chloride showed similar concentrations in both seasons. When the seasonal difference in rainfall amount is taken into consideration, the deposition fluxes are only slightly lower for most species during the wet season than during the dry season, again with the exception of chloride, potassium, and sodium. Sodium and chloride are present in the same ratio as in sea salt; rapid advection of air masses of marine origin to the central Amazon Basin during the wet season may be responsible for the observed higher deposition flux of these species. Statistical analysis suggests that sulfate is, to a large extent, of marine (sea salt and biogenic) origin, but that long-range transport of combustion-derived aerosols also makes a significant contribution to sulfate and nitrate levels in Amazonian rain. Organic acid concentrations in rain were responsible for a large fraction of the observed precipitation acidity; their concentration was strongly influenced by gas/liquid interactions.

  4. On the Promotion of Higher Vocational Basketball Teaching Reform by Using Module-concentrated Teach-ing Mode%运用板块集中教学模式,促进高职篮球教学改革

    Institute of Scientific and Technical Information of China (English)

    闵军

    2013-01-01

    伴随职业教育改革的深入推进,高职院校对课程教学改革的重视程度也较以往有较大幅度提升。对高职篮球教学而言亦是如此。而“板块集中”教学模式的提出及运用,对提升高职篮球教学质量,促进学生德智体美全面发展,推动高职篮球教学改革。本文简要概述“板块集中”教学模式内涵,分析了板块集中教学模式相较于传统教学存在的优势,进而从激趣、课前预热、完善板块体系,以及集中诊断问题四个方面探讨高职篮球教学中运用“板块集中”教学模式的策略。%With the further promotion of vocational education re-form, more attention is given to curriculum teaching reform in higher vocational colleges, as well as higher vocational basketball teaching. The proposal and use of"module-concentrated"teach-ing mode plays an important role in improving the quality of higher vocational basketball teaching, promoting the comprehen-sive development of students, and expediting the reform of higher vocational basketball teaching. This paper briefly summarizes the connotation of "module-concentrated" teaching mode, analyzes its advantages compared with traditional teaching, and then ex-plores the strategies of using "module-concentrated" teaching mode in higher vocational basketball teaching from such four as-pects as stimulating interest, pre-class warming-up, improving module system, and concentrated inspection.

  5. 蔡英文两岸政策策略、内涵及其影响%Strategy, Connotations and Influence of Tsai Ing-wen’s Cross-Strait Policy

    Institute of Scientific and Technical Information of China (English)

    倪永杰

    2016-01-01

    蔡英文两岸政策严重制约两岸关系发展。为创造有利执政的两岸环境,蔡英文采取稳定并降温的两岸策略。自2015年4月抛出“维持两岸现状”后,蔡英文持续调整其两岸政策,“520”讲话释出“宪法论”、民共对话论等重要信息。但调整徒有其表,本质上不接受“九二共识”、不认同“两岸同属一中”,仍不放弃“台独”主张,仍怀有“台独”幻想。蔡的两岸政策选项更是充满了冷漠与对抗,全面推行“文化台独”、“柔性台独”。两岸关系较可能形成“冷对抗”、甚至是强对抗的局面。%Tsai Ing-wen’s cross-Strait policy has seriously hindered the development of the cross-Strait relations. She has taken a stable yet cool strategy so as to create a favorable ruling environment. Ever since the argument of “maintaining the cross-Strait status quo” was produced in April 2015, Tsai has constantly readjusted her cross-Strait policy. Her “520”speech has released some important information such as “constitution theory” and the proposal for opening dialogue between DPP and CPC. However, Tsai’s policy does not, in essence, accept the“1992 Consensus” nor agree with the“One China” principle, implying that she will not give up the idea of “Taiwan independence”. Even worse, the policy is full of cold confrontation as she has been pushing forward a“cultural Taiwan independence” and“flexible Taiwan independence”. As a result,“cold con-frontation” or even overt conflicts may arise across the Taiwan Strait.

  6. Stjórnlagaþing, fjölmiðlar og frambjóðendur. Rannsókn á kynningarmálum frambjóðenda fyrir stjórnlagaþingskosningar 2010

    Directory of Open Access Journals (Sweden)

    Birgir Guðmundsson

    2010-12-01

    Full Text Available Hefðbundnir fjölmiðlar voru ekki í aðalhlutverki við kynningu og umfjöllun um einstaka frambjóðendur í kosningunum til stjórnlagaþings í nóvember 2010. Persónukjör með landið sem eitt kjördæmi þar sem yfir 500 frambjóðendur voru í kjöri er fyrirkomulag sem ekki hentar verklagi og vinnubrögðum hefðbundinna miðla og því er lýðræðislegt hlutverk þeirra takmarkað að þessu leyti. Í greininni er greint frá niðurstöðum könnunar meðal frambjóðenda til þingsins á því hvernig þeir höguðu kynningarmálum sínum og kemur í ljós að netmiðlar voru í aðalhlutverki, sérstaklega samfélagsvefurinn Facebook og miðlar sem ekki teljast til stóru hefðbundnu miðlanna. Í gegnum þessa miðla reyndu frambjóðendur að koma sér og stefnumálum sínum á framfæri inn í almannarými þjóðfélagsumræðunnar. Lítil sem engin tilraun var gerð meðal frambjóðenda til að kaupa sér leið inn í almannarýmið með auglýsingum.

  7. On the Role of Group Psychological Guidance in Promot-ing College Freshmen's Class Learning Style%团体心理辅导对高校新生班级学风的促进作用

    Institute of Scientific and Technical Information of China (English)

    霍中开

    2016-01-01

    为了探索团体心理辅导对大学新生班级学习氛围与人际氛围的影响作用,本研究通过以班级学风为主题的团体心理辅导,对174名大一新生以班级为单位进行为期三周的实验研究,实验结束后采用自编《班级学习氛围》问卷作为评估指标对实验组与对照组进行比较分析。分析结果发现,实验组班级氛围总分、找到共同学习目标的朋友、时间管理、自发学习活动、专业认识和人际氛围题项的得分高于对照组,且差异具有统计学意义(p<0.05)。统计结果显示,短期的团体心理辅导活动对新生班级学习氛围和人际氛围具有促进作用,文章并进一步就团体辅导对高校新生班级的适用性进行了讨论。%To explore the influence of group psychological guid-ance on college freshmen's class learning atmosphere and inter-personal relationship, this paper, through the group psychological guidance themed by class learning style, carried out a three-week experimental research on 174 college freshmen with class as the unit, and then used the self-made questionnaire of"class learn-ing atmosphere"as the evaluation standard to compare and ana-lyze the experimental group and the control group. It was found in the analysis results that the total score in class atmosphere, the scores in making friends with those who have the same learning objectives, time management, autonomous learning activities, professional understanding and interpersonal relationship of the experimental group are higher than those of the control group, and the difference is of statistical significance ( <0.05). It was indicated in the statistical results that short-term group psycho-logical guidance can promote college freshmen's class learning atmosphere and inter personal relationship. This paper then dis-cussed the adaptability of group guidance in college freshmen's class.

  8. Glial involvement in trigeminal central sensitization

    Institute of Scientific and Technical Information of China (English)

    Yu-feng XIE

    2008-01-01

    Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflamma-tion or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analge-sics for orofacial-specific pain with higher efficiency and fewer side-effects.

  9. Large teleseismic P-wave residuals observed at the Alban Hills volcano, Central Italy

    Directory of Open Access Journals (Sweden)

    H. Mahadeva Iyer

    1994-06-01

    Full Text Available We collected teleseismic waveforms from a digital microseismic network deployed by the Istituto Nazionale di Geofisica (ING in collaboration with the U.S. Geological Survey (USGS, on the Alban Hills Quaternary volcano during the 1989-1990 seismic swann. About 50 events were recorded by the network, 30 of them by at least 4 stations. We analysed the data in order to image crustal heterogeneities beneath the volcano. The results show large delay time residuals up to - 1 second for stations located on the volcano with respect to station CP9 of the National Seismic Network located about 20 km to the east, on the Apennines. This suggests that the whole area overlies a broad low-velocity region. Although the ray coverage is not very dense, we model the gross seismic structure beneath the volcano by inverting the teleseismic relative residuals with the ACH technique. The main features detected by tbc inversion are a low-velocity zone beneath the southwestern fiank of tbc volcano, and a high-velocity region beneath the center. The depth extension of these anomalous zones ranges between 5 and 16 km. The correspondence between the low-velocity region and the most recent activity of the volcano (- 0.027 Ma leads us to infer the presence of a still hot magmatic body in the crust beneath the southwestern side of the volcano, whereas the central part overlies the older and colder high-velocity volcanic roots related to the previous central activity (0.7 to 0.3 Ma.

  10. Central Solenoid Insert Technical Specification

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, Nicolai N [ORNL; Smirnov, Alexandre [ORNL

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  11. 76 FR 22746 - Wiregrass Central Railway, LLC-Acquisition and Operation Exemption-Wiregrass Central Railroad...

    Science.gov (United States)

    2011-04-22

    ... Surface Transportation Board Wiregrass Central Railway, LLC--Acquisition and Operation Exemption--Wiregrass Central Railroad Company, Inc. Wiregrass Central Railway, LLC (WCR), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to acquire from Wiregrass Central Railroad Company,...

  12. Central Exclusive Production at LHCb

    CERN Document Server

    McNulty, Ronan

    2016-01-01

    Central Exclusive Production (CEP) is a unique process at hadron machines in which particles are produced via colourless propagators. LHCb have measured the cross-sections for the CEP of vector mesons, $J/\\psi,\\psi(2S),\\Upsilon(1S),\\Upsilon(2S)$ and $\\Upsilon(3S)$, which are photo-produced. In the double pomeron exchange process, preliminary measurements have been made of $\\chi_{c0},\\chi_{c1}, \\chi_{c2}$ meson production while the first observations of the CEP of pairs of charmonia, $J/\\psi J/\\psi$ and $J/\\psi \\psi(2S)$, have been made and limits obtained on the pair production of other charmonia.

  13. Centralized Allocation in Multiple Markets

    DEFF Research Database (Denmark)

    Monte, Daniel; Tumennasan, Norovsambuu

    The problem of allocating indivisible objects to different agents, where each indi vidual is assigned at most one object, has been widely studied. Pápai (2000) shows that the set of strategy-proof, nonbossy, Pareto optimal and reallocation-proof rules are hierarchical exchange rules | generalizat......The problem of allocating indivisible objects to different agents, where each indi vidual is assigned at most one object, has been widely studied. Pápai (2000) shows that the set of strategy-proof, nonbossy, Pareto optimal and reallocation-proof rules are hierarchical exchange rules...... | generalizations of Gale's Top Trading Cycles mechanism. We study the centralized allocation that takes place in multiple markets. For example, the assignment of multiple types of indivisible objects; or the assignment of objects in successive periods. We show that the set of strategy-proof, Pareto efficient...

  14. CST-01-Central Standard Timing

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    薄如蝉翼名为CentralStandardTiming的工作室推出了E—ink材质代号为CST-01的手表,其厚度仅为0.8mm,号称全球最薄。一次充电10分钟便可连续使用15年。该手表屏幕由多层柔性材料构成。整体十分轻巧并且可弯曲,腕带则采用了柔性不锈钢材质。CST-01的预售价格为129美元。约合人民币800元,目前已经在著名的集资网站Kickstarter上创建项目。

  15. ITER Central Solenoid Module Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Smith, John [General Atomics, San Diego, CA (United States)

    2016-09-23

    The fabrication of the modules for the ITER Central Solenoid (CS) has started in a dedicated production facility located in Poway, California, USA. The necessary tools have been designed, built, installed, and tested in the facility to enable the start of production. The current schedule has first module fabrication completed in 2017, followed by testing and subsequent shipment to ITER. The Central Solenoid is a key component of the ITER tokamak providing the inductive voltage to initiate and sustain the plasma current and to position and shape the plasma. The design of the CS has been a collaborative effort between the US ITER Project Office (US ITER), the international ITER Organization (IO) and General Atomics (GA). GA’s responsibility includes: completing the fabrication design, developing and qualifying the fabrication processes and tools, and then completing the fabrication of the seven 110 tonne CS modules. The modules will be shipped separately to the ITER site, and then stacked and aligned in the Assembly Hall prior to insertion in the core of the ITER tokamak. A dedicated facility in Poway, California, USA has been established by GA to complete the fabrication of the seven modules. Infrastructure improvements included thick reinforced concrete floors, a diesel generator for backup power, along with, cranes for moving the tooling within the facility. The fabrication process for a single module requires approximately 22 months followed by five months of testing, which includes preliminary electrical testing followed by high current (48.5 kA) tests at 4.7K. The production of the seven modules is completed in a parallel fashion through ten process stations. The process stations have been designed and built with most stations having completed testing and qualification for carrying out the required fabrication processes. The final qualification step for each process station is achieved by the successful production of a prototype coil. Fabrication of the first

  16. Performance contracting in central government in Denmark

    DEFF Research Database (Denmark)

    Kristiansen, Mads Bøge

    2015-01-01

    in organisational structure, tasks, culture and time with performance contracts is expected to affect the contract content, hypotheses on variation across agencies are deduced. The empirical basis of the paper is a study of all performance contracts between parent ministries and subordinate agencies in Danish......This paper looks into performance contracting in Danish central government. Management by Objectives and Results (MBOR) was adopted in central government in Denmark during the 1980s and early 1990s. In 1991, performance contracts between parent ministries and their agencies were introduced...... in Danish central government. Since their introduction, performance contracts have become central elements in the steering and management of agencies in central government in Denmark, and today they are nearly universally adopted in central government. In Denmark, the Ministry of Finance is responsible...

  17. Hirsch index as a network centrality measure

    CERN Document Server

    Campiteli, Monica G; Soles, Paulo R C; Soares, Leonardo H D; Kinouchi, Osame

    2010-01-01

    We study the h Hirsch index as a local node centrality measure for complex networks in general. The h index is compared with the Degree centrality (a local measure), the Betweenness and Eigenvector centralities (two non-local measures) in the case of a biological network (Yeast interaction protein-protein network) and a linguistic network (Moby Thesaurus II) as test environments. In both networks, the Hirsch index has poor correlation with Betweenness centrality but correlates well with Eigenvector centrality, specially for the more important nodes that are relevant for ranking purposes, say in Search Machine Optimization. In the thesaurus network, the h index seems even to outperform the Eigenvector centrality measure as evaluated by simple linguistic criteria.

  18. A matrix analysis of different centrality measures

    CERN Document Server

    Benzi, Michele

    2013-01-01

    Node centrality measures including degree, eigenvector, Katz and subgraph centralities are analyzed for both undirected and directed networks. We show how parameter-dependent measures, such as Katz and subgraph centrality, can be "tuned" to interpolate between degree and eigenvector centrality, which appear as limiting cases of the other measures. We interpret our finding in terms of the local and global influence of a given node in the graph as measured by graph walks of different length through that node. Our analysis gives some guidance for the choice of parameters in Katz and subgraph centrality, and provides an explanation for the observed correlations between different centrality measures and for the stability exhibited by the ranking vectors for certain parameter ranges. The important role played by the spectral gap of the adjacency matrix is also highlighted.

  19. Reduced central blood volume in cirrhosis

    DEFF Research Database (Denmark)

    Bendtsen, F; Henriksen, Jens Henrik Sahl; Sørensen, T I

    1989-01-01

    for measuring the central blood volume. We have developed a method that enables us to determine directly the central blood volume, i.e., the blood volume in the heart cavities, lungs, and central arterial tree. In 60 patients with cirrhosis and 16 control subjects the central blood volume was assessed according......The pathogenesis of ascites formation in cirrhosis is uncertain. It is still under debate whether the effective blood volume is reduced (underfilling theory) or whether the intravascular compartment is expanded (overflow theory). This problem has not yet been solved because of insufficient tools...... to the kinetic theory as the product of cardiac output and mean transit time of the central vascular bed. Central blood volume was significantly smaller in patients with cirrhosis than in controls (mean 21 vs. 27 ml/kg estimated ideal body weight, p less than 0.001; 25% vs. 33% of the total blood volume, p less...

  20. Market strategies for Central American dry beans.

    OpenAIRE

    Mertínez, Lourdes; Bernsten, Richard; Zamora, Miguel

    2004-01-01

    In the past few years, the dry bean sub-sector in CentralAmerica has witnessed many dynamic changes. Unless wefind ways to increase the competitiveness of the regionalbean sub-sector, Central American countries will likelyexperience significant negative social and economic impacts,especially since these countries are facing the challenge ofadjusting to new open markets, such as the Central AmericanFree Trade Agreement (CAFTA). Bean traders, retailers, andknowledgeable government official in C...

  1. Transpleural central venous catheter discovered during thoracotomy

    Directory of Open Access Journals (Sweden)

    Ashima Malhotra

    2014-01-01

    Full Text Available We report an uncommon complication of subclavian central venous catheterization, discovered at thoracotomy. The central venous catheter (CVC was placed by left infraclavicular route after induction of general anesthesia. CVC was secured after aspiration of blood and satisfactory central venous tracing. On thoracotomy, CVC was noticed to traverse the pleural cavity while the tracing was normal. CVC was thus removed consequent to which bleeding from each puncture site was noticed, that were secured surgically.

  2. 对人大新闻采编工作的认识和思考%Understanding and Thinking on the Gathering and Edit-ing of News Related to the National People's Congress (NPC)

    Institute of Scientific and Technical Information of China (English)

    余振国

    2015-01-01

    The gathering and editing of news related to the NPC is the basis and premise of the news and propaganda work of the NPC, so the efficient gathering and editing of news related to the NPC plays an important role in further strengthening and improv-ing the propaganda work of the NPC. The system of people's congress, as a democratic system with Chinese characteristics, is the fundamental political system of our country, and it accords with China's national conditions to the largest extent. To well im-plement the propaganda work of the NPC is of great significance for the broad masses of the people to know about the system of people's congress as well as how the NPC and its standing com-mittee perform its responsibilities on behalf of the people, for the broad masses of the people to strengthen their democratic and le-gal consciousness, and for the promotion of the harmonious and stable development of economy and the society. To well imple-ment the gathering and editing of news related to the NPC, rele-vant editors must go to the grassroots, seek the realities, and im-merse themselves among common representatives. Besides, they should also strengthen the learning of the professional knowledge of the NPC, enhance the learning of legal knowledge, improve their personal quality and ability of deviation and error correction, so as to further improve the quality of gathering and editing and make it precious and detailed, and thereby make a positive con-tribution to the propaganda of the system of people's congress, and the promotion of the harmonious and stable development of economy and the society.%人大新闻采编工作是人大新闻宣传工作的基础和前提,做好人大新闻采编工作,对于进一步加强和改进人大宣传工作具有重要作用。人民代表大会制度是我国的根本政治制度,是具有中国特色的民主制度,最符合中国国情。做好人大宣传工作,对于广大人民群众了解人民代表大会制度

  3. Analysis of risk factors of indwell ing catheter associated urinary tract infection and nursing prevention%留置尿管相关性尿路感染的危险因素分析及护理预防

    Institute of Scientific and Technical Information of China (English)

    王竹君; 付林; 王玉; 陈汉霞

    2014-01-01

    Objective:To probe into the risk factors of indwelling cathe-ter associated urinary tract infection,so as to improve the clinical medi-cal security.Methods:A total of 255 patients with indwelled urinary and data integrity were included.According to whether catheter relat-ed urinary infection occurred or not,all patients were divided into infec-tion group (73 cases)and not infection group (182 cases).Single fac-tor analysis was used to investigate the differences of risk factors of catheter related urinary infection between both groups,and further Logistic regression analysis was used to analyze independent risk fac-tors of influencing catheter related urinary infection.Results:Univa-riate analysis of two groups of data showed that the age,indwelling uri-nary tube time ≥ 7 d,application of hormone,operation ≥ 2 or more times,bladder irrigation <7 times every week,urethral opening clean-ing<7 times every week in infection group were higher than those in non infection group,all differences were statistically significant (all P <0.05).Multi factor analysis of two groups data showed that in infec-tion groups,the age,indwelling urinary tube time≥7d,operation≥2 or more times and urethral opening cleaning<7 times every week were high-er than those in non infection group,the difference was statistically significant (P < 0.05).Conclusion:Old age,long indwelling time,the operation of more than 2 times and urethral mouth cleaning <7 times per week are the independent risk factors of catheter related urinary tract infection.%[目的]探讨留置尿管相关性尿路感染的危险因素,以提高临床医疗安全性。[方法]纳入资料完整的留置尿管病人255例,以是否发生导管相关性尿路感染为判断标准分为感染组(73例)和非感染组(182例)。采用单因素分析两组导管相关性尿路感染的危险因素的差异,并进一步通过 Logistic 回归分析影响导管相关性尿路感染发生的独立危险因素。[结果]

  4. Un episodio del pensamiento francés de la autonomía. Benjamin Constant y las idées très ingénieuses

    Directory of Open Access Journals (Sweden)

    Francisco Gelman Constantin

    2014-03-01

    Full Text Available UN EPISODIO DEL PENSAMIENTO FRANCÉS DE LA AUTONOMÍA Benjamin Constant y las idées très ingénieuses   Francisco Gelman Constantin Facultad de Filosofía y Letras, Universidad de Buenos Aires     Abstract – This paper attempts a consideration of the significance of Benjamin Constant’s aesthetic thoughts within the context of the history of the concept of “aesthetic autonomy”. With that in mind it reevaluates his transformation of the German tradition, by way of its binding to the social theory corresponding to the cultural and historical analysis of early French Romanticism. Taking the coinage of the expression “art for art’s sake” as a starting point, this paper reconstructs the whole of Constant’s thought-system, as well as its exchanges with some of his contemporaries –namely Mme. de Staël and Henry Crabb Robinson– in the means of understanding the proper reach of the conceptual novelties brought in by him, as can be seen from the standing point of Begriffsgeschichte. The paper deals not only with his postulates referring specifically to a negative relationship towards the mercantile society, but also with the analogies he establishes between art, love, religion and morality, while it furthermore examines his theory of social autonomy. The reflexive setting together of this different elements, assembled from his political essays, his journals, the novel Adolphe and other writings, brings to the light a general form of a thought of the autonomous, which explains the manner in which Constant understands aesthetic autonomy in particular, by way of his collaboration and dissent with his European colleagues.   Keywords: autonomy; Constant; art for art’s sake; Begriffsgeschichte; religion     Resumen – Este trabajo se propone reconsiderar la importancia de las reflexiones estéticas de Benjamin Constant en el contexto de la historia del concepto de autonomía estética. Para ello reevalúa las transformaciones

  5. 羅振玉日本教育考察與晚清學制制定的關係 Chen-Yu Lo’ Educational Visit to Japan and the Drafting of School Systems in Late Ch’ing

    Directory of Open Access Journals (Sweden)

    周愚文 Yu-Wen Chou

    2015-03-01

    materials public, and published his account of the visit to Japan, he also presented his own version of educational plan in the Journal “Education World”. Unfortunately Lo was not engaged in the planning the Ren-yin and Kuei-mao school systems, and his publications were only used as one of reference sources, even though two of his proposals probably adapted by the officials in charge. The planner of Kuei-mao, I Chen, was a translator of several Japanese education acts and he took the educational visit to Japan with Lo; however, because the key policy-makers were inexperienced the school system borrowed from Japan could not completely meet the educational need of Ch’ing dynasty.

  6. The Centrality of Organization Design

    Directory of Open Access Journals (Sweden)

    Raymond E. Miles

    2012-05-01

    Full Text Available I am excited about this new journal focused on the subject of organization design. In my view, organization design is a central issue in the field of management. Designing an organization requires an understanding of strategy, as we pointed out some time ago (Miles & Snow, 1978. For example, if you want to be a prospector (a first-mover strategy, you have to design your firm to move quickly in new directions, which is likely to require that it be arranged so that various kinds of teams can interact across organizational units and levels. Designing an organization to follow a first-mover strategy also requires both an understanding of leadership and a commitment to the free flow of information throughout the organization. Leaders must understand how cross-functional teams pursue ideas and opportunities, and they must facilitate collaborative knowledge sharing to drive innovations that help the firm operate entrepreneurially. Because an organization is a complex, dynamic system, perhaps no other single topic is so deeply implanted at the core of management, organization theory, and organizational behavior as organization design. Moreover, organization design once was, and could be again, the topic of an ongoing dialogue between managers and academics focused on business organizations.

  7. Maximal switchability of centralized networks

    Science.gov (United States)

    Vakulenko, Sergei; Morozov, Ivan; Radulescu, Ovidiu

    2016-08-01

    We consider continuous time Hopfield-like recurrent networks as dynamical models for gene regulation and neural networks. We are interested in networks that contain n high-degree nodes preferably connected to a large number of N s weakly connected satellites, a property that we call n/N s -centrality. If the hub dynamics is slow, we obtain that the large time network dynamics is completely defined by the hub dynamics. Moreover, such networks are maximally flexible and switchable, in the sense that they can switch from a globally attractive rest state to any structurally stable dynamics when the response time of a special controller hub is changed. In particular, we show that a decrease of the controller hub response time can lead to a sharp variation in the network attractor structure: we can obtain a set of new local attractors, whose number can increase exponentially with N, the total number of nodes of the nework. These new attractors can be periodic or even chaotic. We provide an algorithm, which allows us to design networks with the desired switching properties, or to learn them from time series, by adjusting the interactions between hubs and satellites. Such switchable networks could be used as models for context dependent adaptation in functional genetics or as models for cognitive functions in neuroscience.

  8. Central nervous system tuberculosis: MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kioumehr, F.; Dadsetan, M.R.; Rooholamini, S.A.; Au, A.

    1994-02-01

    The MRI findings of 18 proven cases of central nervous system (CNS) tuberculosis were reviewed; 10 patients were seropositive for HIV. All had medical, laboratory, or surgical proof of CNS tuberculosis. Eleven patients had meningitis, of whom two also had arachnoiditis. Five patients had focal intra-axial tuberculomas: four brain masses and one an intramedullary spinal lesion. Two patients had focal extra-axial tuberculomas: one in the pontine cistern, and one in the spine. In all 11 patients with meningitis MRI showed diffuse, thick, meningeal enhancement. All intraparenchymal tuberculomas showed low signal intensity on T2-weighted images and ring or nodular enhancement. The extra-axial tuberculomas had areas isointense or hypointense relative to normal brain and spinal cord on T2-weighted images. Although tuberculous meningitis cannot be differentiated from other meningitides on the basis of MR findings, intraparenchymal tuberculomas show characteristic T2 shortening, not found in most other space-occupying lesions. In the appropriate clinical setting, tuberculoma should be considered. (orig.)

  9. Towards a centralized Grid Speedometer

    Energy Technology Data Exchange (ETDEWEB)

    Dzhunov, I. [CERN; Andreeva, J. [CERN; Fajardo, E.; Gutsche, O.; Luyckx, S.; Saiz, P. [CERN

    2014-01-01

    Given the distributed nature of the Worldwide LHC Computing Grid and the way CPU resources are pledged and shared around the globe, Virtual Organizations (VOs) face the challenge of monitoring the use of these resources. For CMS and the operation of centralized workflows, the monitoring of how many production jobs are running and pending in the Glidein WMS production pools is very important. The Dashboard Site Status Board (SSB) provides a very flexible framework to collect, aggregate and visualize data. The CMS production monitoring team uses the SSB to define the metrics that have to be monitored and the alarms that have to be raised. During the integration of CMS production monitoring into the SSB, several enhancements to the core functionality of the SSB were required, They were implemented in a generic way, so that other VOs using the SSB can exploit them. Alongside these enhancements, there were a number of changes to the core of the SSB framework. This paper presents the details of the implementation and the advantages for current and future usage of the new features in SSB.

  10. Towards a centralized Grid Speedometer

    CERN Document Server

    Gutsche, Oliver

    2013-01-01

    Given the distributed nature of the grid and the way CPU resources are pledged and scared around the globe, VOs are facing the challenge to monitor the use of these resources. For CMS and the operation of centralized workflows the monitoring of how many production jobs are running and pending in the Glidein WMS production pools is very important. The Dashboard SSB (Site Status Board) provides a very flexible framework to collect, aggregate and visualize data. The CMS production monitoring team uses the SSB to define the metrics that have to be monitored and the alarms that have to be set. During the integration of the CMS production monitoring into the SSB, several enhancements to the core functionality of the SSB were implemented; all in a generic way, so that other VOs using the SSB can use them as well. Alongside these enhancements, there were a few changes to the core of the SSB framework from which the CMS production team was able to benefit. We will present the details of the implementation and the adva...

  11. [Aniseikonia of central serous chorioretinopathy].

    Science.gov (United States)

    Hisada, H; Awaya, S

    1992-03-01

    Central serous chorioretinopathy (CRS) is one of the typical diseases that accompany micropsia. However very little is known about micropsia of CRS, because of the difficulty to measure "aniseikonia" in terms of micropsia. Aniseikonia in 65 cases of CRS was measured quantitatively by Awaya's New Aniseikonia Tests (NAT). The tests were performed at two different distances of 40 cm (visual angle: 6 degrees) and 20 cm (12 degrees) and under 4 meridians of the halfmoon on NAT, horizontal, 45 degrees, vertical and 135 degrees, respectively. The mean value of aniseikonia under each testing condition was as follows: 6 degrees horizontal -3.13%, 45 degrees -2.56%, vertical -2.13%, 135 degrees -2.57%, 12 degrees; horizontal -1.38%, 45 degrees -1.69%, vertical -1.84%, 135 degrees -1.50%. At 6 degrees aniseikonia is larger in the horizontal meridian than in the vertical with statistical significance (t-test, p less than 0.05), while at 12 degrees aniseikonia is smaller than at 6 degrees and shows no particular tendency in terms of meridian. The phenomenon observed at 6 degrees may be what is called "oriented metamorphopsia".

  12. Concept of the central clip

    DEFF Research Database (Denmark)

    Alegria-Barrero, Eduardo; Chan, Pak Hei; Foin, Nicolas

    2014-01-01

    -risk surgical population with severe mitral regurgitation (MR). METHODS AND RESULTS: Patients with severe MR (3 or 4+) and high operative risk (as defined by logistic EuroSCORE) refused for conventional mitral valve repair were considered for MitraClip(®). The procedure was performed under general anaesthesia...... with transoesophageal echocardiographic (TOE) guidance. Device success was defined as placement of one or more MitraClips(®) with a reduction of MR to ≤2+. Patients were followed up clinically and with TOE at one month and one year. From September 2009 to March 2012, 43 patients with severe MR with a mean age of 74.......8±10.7 years (30 males, 13 females; mean logistic EuroSCORE 24.1±11, mean LVEF 47.5±18.5%; mean±SD) were treated. Median follow-up was 385 days (104-630; Q1-Q3). Device implantation success was 93%. All patients were treated following the central clip concept: 52.5% of MR was degenerative in aetiology and 47...

  13. Central venous line complications and tip detection

    Directory of Open Access Journals (Sweden)

    Ameneh Rezaee Gheshlaghi

    2015-06-01

    Full Text Available Central venous line is one of a creative instrument that saves human’s life in critical medical situation. Central venous line access is frequently involved in the disease management. It is used for rapid fluid therapy, transvenous pacemakers, infusion of some medications, hemodialysis or plasmapheresis and etc. Most of the emergency departments have some staffs that are trained for central venous line insertion but related complications occur during central venous line placement.Central venous line might have some complications and complication follow-up should be considered. Thromboembolism and infection are two important medical complications. Arterial puncture, hematoma, pneumothorax and hemothorax are mechanical Central venous line complications. Chest X-ray and some other techniques should be used for detecting these complications.Central venous line tip misplace is a considerable problem for emergency department staffs, previously chest X-ray has been used for central venous line misplace detection. In some recent studies, contrast-enhanced ultrasonography and intravascular electrocardiography have been used for central venous line misplace.

  14. JPRS Report, Science & Technology. Europe: Economic Competitiveness

    Science.gov (United States)

    2007-11-02

    its partners, the Spanish companies ENDESA [National Electric Power Enterprise, Inc.], Hidroelectrica Espanola, Sevillana de Electricidade ...Hidroelectrica del Cantabrico, and the Electricidade de Portugal Company, the carbon dioxide emissions from the plant will be reduced by 20 percent, as

  15. A global central banker competency model

    Directory of Open Access Journals (Sweden)

    David W. Brits

    2014-02-01

    Full Text Available Orientation: No comprehensive, integrated competency model exists for central bankers. Due to the importance of central banks in the context of the ongoing global financial crisis, it was deemed necessary to design and validate such a model.Research purpose: To craft and validate a comprehensive, integrated global central banker competency model (GCBCM and to assess whether central banks using the GCBCM for training have a higher global influence.Motivation for the study: Limited consensus exists globally about what constitutes a ‘competent’ central banker. A quantitatively validated GCBCM would make a significant contribution to enhancing central banker effectiveness, and also provide a solid foundation for effective people management.Research approach, design and method: A blended quantitative and qualitative research approach was taken. Two sets of hypotheses were tested regarding the relationships between the GCBCM and the training offered, using the model on the one hand, and a central bank’s global influence on the other.Main findings: The GCBCM was generally accepted across all participating central banks globally, although some differences were found between central banks with higher and lower global influence. The actual training offered by central banks in terms of the model, however, is generally limited to technical-functional skills. The GCBCM is therefore at present predominantly aspirational. Significant differences were found regarding the training offered.Practical/managerial implications: By adopting the GCBCM, central banks would be able to develop organisation-specific competency models in order to enhance their organisational capabilities and play their increasingly important global role more effectively.Contribution: A generic conceptual framework for the crafting of a competency model with evaluation criteria was developed. A GCBCM was quantitatively validated.

  16. Haemangiopericytoma of central nervous system

    Energy Technology Data Exchange (ETDEWEB)

    Borg, M.F.; Benjamin, C.S. [Auckland Hospital, Auckland (New Zealand). Dept. of Clinical Oncology

    1995-02-01

    The records of four patients presenting with a histological diagnosis of haemangiopericytoma of the central nervous system, in Auckland, New Zealand, between 1970 and 1990 were reviewed retrospectively, with the aim of determining the natural history of the disease and response to various treatment modalities. Three out of the four patients reviewed presented with primary cerebral disease and the fourth with a primary spinal cord tumour. All three cerebral primary patients were initially treated with local surgical excision. All three patients received radical radiotherapy following local recurrence. The first two patients remained disease-free locally although one patient developed a solitary liver metastasis 5 years after radiotherapy. The third patient was referred with multiple cerebral metastases and failed to respond to radiotherapy. The patient with the primary lesion in the spinal cord was treated with local excision followed by postoperative radiotherapy and remains disease-free 17 years after treatment. One patient failed to respond to chemotherapy, prescribed to treat a local recurrence adjacent to the previous radiotherapy field. This was successfully excised subsequently. The patient presenting with multiple cerebral metastases was the only patient to die of this disease. Results suggest that local recurrence is avoidable with adequate wide excision of the primary tumour followed by local radical radiotherapy. The role of chemotherapy remains controversial and no conclusion could be drawn regarding the role of palliative radiotherapy from this study. Active treatment and long-term follow-up are necessary because of the relative aggressiveness of this disease and the propensity for late relapses. 22 refs., 2 tabs., 6 figs.

  17. Tethyan evolution of central Asia

    Energy Technology Data Exchange (ETDEWEB)

    Sengor, A.M.C. (Instanbul Technical Univ. (Turkey))

    1990-05-01

    The study area extends from the eastern shores of the Caspian Sea in the west to the Helan Shan and Longmen Shan in the east and from about 40{degree}N parallel in the north to the neo-Tethyan sutures in the south, thus including what is called Middle Asia in the Soviet literature. In the region thus delineated lies the boundary between the largely late Paleozoic core of Asia (Altaids) and the Tethyside superorogenic complex. This boundary passes through continental objects that collided with nuclear Asia in the late Paleozoic to terminate its Altaid evolution. Subduction to the south of some of these had commenced before they collided (e.g., Tarim in the Kuen-Lun), in others later (e.g., South Ghissar area west of Pamirs). This subduction 1ed, in the late Paleozoic, to the opening of marginal basins, at least one of which may be partly extant (Tarim). Giant subduction accretion complexes of Paleozoic to earliest Triassic age dominate farther south in the basement of Turan (mainly in Turkmenian SSR) and in the Kuen-Lun/Nan Shan ranges. No discrete continental collisions or any continental basement in these regions could be unequivocally recognized contrary to most current interpretations. Magmatic arcs that developed along the southern margin of Asia in the late Paleozoic to early Mesozoic grew atop these subduction-accretion complexes and record a gradual southerly migration of magmatism through time. Subduction also dominated the northern margin of Gondwanaland between Iran and China in late Paleozoic time, although the record in Afghanistan and northwest Tibet is scrappy. It led to back-arc basin formation, which in Iran and Oman became neo-Tethys and, in at least parts of central Asia, the Waser-Mushan-Pshart/Banggong Co-Nu Jiang ocean. This ocean was probably connected with the Omani part of the neo-Tethys via the Sistan region.

  18. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of a constant hydraulic conductivity value for the Central Oklahoma aquifer in central Oklahoma. This area encompasses...

  19. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized water-level elevation contours for the Central Oklahoma aquifer in central Oklahoma. This area encompasses all or part of...

  20. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized aquifer boundaries created for a previously published report about the Central Oklahoma aquifer in central Oklahoma. This area...

  1. Digital data sets that describe aquifer characteristics of the Central Oklahoma aquifer in central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of a constant recharge value for the Central Oklahoma aquifer in central Oklahoma. This area encompasses all or part of...

  2. Novel central nervous system drug delivery systems.

    Science.gov (United States)

    Stockwell, Jocelyn; Abdi, Nabiha; Lu, Xiaofan; Maheshwari, Oshin; Taghibiglou, Changiz

    2014-05-01

    For decades, biomedical and pharmaceutical researchers have worked to devise new and more effective therapeutics to treat diseases affecting the central nervous system. The blood-brain barrier effectively protects the brain, but poses a profound challenge to drug delivery across this barrier. Many traditional drugs cannot cross the blood-brain barrier in appreciable concentrations, with less than 1% of most drugs reaching the central nervous system, leading to a lack of available treatments for many central nervous system diseases, such as stroke, neurodegenerative disorders, and brain tumors. Due to the ineffective nature of most treatments for central nervous system disorders, the development of novel drug delivery systems is an area of great interest and active research. Multiple novel strategies show promise for effective central nervous system drug delivery, giving potential for more effective and safer therapies in the future. This review outlines several novel drug delivery techniques, including intranasal drug delivery, nanoparticles, drug modifications, convection-enhanced infusion, and ultrasound-mediated drug delivery. It also assesses possible clinical applications, limitations, and examples of current clinical and preclinical research for each of these drug delivery approaches. Improved central nervous system drug delivery is extremely important and will allow for improved treatment of central nervous system diseases, causing improved therapies for those who are affected by central nervous system diseases.

  3. Central Life Interests and Job Satisfaction.

    Science.gov (United States)

    Dubin, Robert; And Others

    Data on central life interests (CLI) and five aspects of job satisfaction were obtained in a sample of bluecollar males and two samples of clerical females. Both a multiple discriminant analysis and a bivariate analysis were performed. The results of these analyses showed that central life interest was significantly related to the total set of job…

  4. International Regulation of Central Arctic Ocean Fisheries

    NARCIS (Netherlands)

    Molenaar, E.J.

    2016-01-01

    Due in particular to the impacts of climate change, the adequacy of the international regulation of Central Arctic Ocean fisheries has come under increasing scrutiny in recent years. As shown in this article, however, international regulation of Central Arctic Ocean fisheries is by no means entirely

  5. An unusual Complication of Central Venous Cannulation

    Directory of Open Access Journals (Sweden)

    Ashvini Kumar

    2013-04-01

    Full Text Available Central venous catheter (CVC hub fracture is a rare complication of central venous cannulation. We report a case where catheter hub fracture was detected immediately after CVC insertion. Causes of catheter hub fracture and its complications are discussed.

  6. The Latino Experience in Central Falls

    Science.gov (United States)

    Holland, William R.

    2011-01-01

    Central Falls is, by far, the poorest community in Rhode Island. More than 40 percent of the children under 18 live in poverty, and 40 percent of that group live in severe poverty. At Central Falls High School, low-income Latino students have fallen behind their white counterparts, with shockingly low graduation, poor literacy, and low…

  7. Computing betweenness centrality in external memory

    DEFF Research Database (Denmark)

    Arge, Lars; Goodrich, Michael T.; Walderveen, Freek van

    2013-01-01

    Betweenness centrality is one of the most well-known measures of the importance of nodes in a social-network graph. In this paper we describe the first known external-memory and cache-oblivious algorithms for computing betweenness centrality. We present four different external-memory algorithms...

  8. Traveling Policies: Hijacked in Central Asia

    Science.gov (United States)

    Silova, Iveta

    2005-01-01

    Since the collapse of the Soviet Union, Central Asian education reform discourses have become increasingly similar to distinctive Western policy discourses traveling globally across national boundaries. Tracing the trajectory of "traveling policies" in Central Asia, this article discusses the way Western education discourses have been…

  9. China-Central Asia Power Cooperation Outlook

    Institute of Scientific and Technical Information of China (English)

    Luo

    2010-01-01

    After analyzing the basic information,distribution of energy resources and condition of power industry in Central Asia, the high feasibility for China to cooperate closely with Central Asia in transnational power interconnection, power investment and technology exchanges, etc. is studied. Furthermore, the forms, mechanisms, existing problems and suggestions for the improvement of current policies related to the power cooperation are proposed.

  10. An overview of CMS central hadron calorimeter

    CERN Document Server

    Katta, S

    2002-01-01

    The central hadron calorimeter for CMS detector is a sampling calorimeter with active medium as scintillator plates interleaved with brass absorber plates. It covers the central pseudorapidity region (¿ eta ¿<3.0). The design and construction aspects are reported. The status of construction and assembly of various subdetectors of HCAL are presented. (5 refs).

  11. The Cartan Matrix of a Centralizer Algebra

    Indian Academy of Sciences (India)

    Umesh V Dubey; Amritanshu Prasad; Pooja Singla

    2012-02-01

    The centralizer algebra of a matrix consists of those matrices that commute with it. We investigate the basic representation-theoretic invariants of centralizer algebras, namely their radicals, projective indecomposable modules, injective indecomposable modules, simple modules and Cartan matrices. With the help of our Cartan matrix calculations we determine their global dimensions. Many of these algebras are of infinite global dimension.

  12. Central bank independence and financial instability

    NARCIS (Netherlands)

    Klomp, J.G.; de Haan, J.

    2009-01-01

    It has been argued that central bank independence (CBI) may not only be beneficial for reaching the objective of price stability, but also for maintaining financial stability. Greater independence from external pressure implies that central banks are less politically constrained in acting to prevent

  13. A SCALED CENTRAL PATH FOR LINEAR PROGRAMMING

    Institute of Scientific and Technical Information of China (English)

    Ya-xiang Yuan

    2001-01-01

    Interior point methods are very efficient methods for solving large scale linear programming problems. The central path plays a very important role in interior point methods. In this paper we propose a new central path, which scales the variables. Thus it has the advantage of forcing the path to have roughly the same distance from each active constraint boundary near the solution.

  14. Traveling Policies: Hijacked in Central Asia

    Science.gov (United States)

    Silova, Iveta

    2005-01-01

    Since the collapse of the Soviet Union, Central Asian education reform discourses have become increasingly similar to distinctive Western policy discourses traveling globally across national boundaries. Tracing the trajectory of "traveling policies" in Central Asia, this article discusses the way Western education discourses have been hybridized…

  15. Central registry in psychiatry: A structured review

    Directory of Open Access Journals (Sweden)

    Jyoti Prakash

    2014-01-01

    Full Text Available Background: Central registry in psychiatry is being practiced in few countries and has been found useful in research and clinical management. Role of central registry has also expanded over the years. Materials and Methods: All accessible internet database Medline, Scopus, Embase were accessed from 1990 till date. Available data were systematically reviewed in structured manner and analyzed. Results: Central registry was found useful in epidemiological analysis, association studies, outcome studies, comorbidity studies, forensic issue, effective of medication, qualitative analysis etc., Conclusion: Central registry proves to be effective tool in quantitative and qualitative understanding of psychiatry practice. Findings of studies from central registry can be useful in modifying best practice and evidence based treatment in psychiatry.

  16. Central differences, Euler numbers and symbolic methods

    CERN Document Server

    Dowker, J S

    2013-01-01

    I relate some coefficients encountered when computing the functional determinants on spheres to the central differentials of nothing. In doing this I use some historic works, in particular transcribing the elegant symbolic formalism of Jeffery (1861) into central difference form which has computational advantages for Euler numbers, as discovered by Shovelton (1915). I derive sum rules for these, and for the central differentials, the proof of which involves an interesting expression for powers of sech x as multiple derivatives. I present a more general, symbolic treatment of central difference calculus which allows known, and unknown, things to be obtained in an elegant and compact fashion gaining, at no cost, the expansion of the powers of the inverse sinh, a basic central function. Systematic use is made of the operator 2 asinh(D/2). Umbral calculus is employed to compress the operator formalism. For example the orthogonality/completeness of the factorial numbers, of the first and second kinds, translates, ...

  17. Central station market development strategies for photovoltaics

    Science.gov (United States)

    1980-01-01

    Federal market development strategies designed to accelerate the market penetration of central station applications of photovoltaic energy system are analyzed. Since no specific goals were set for the commercialization of central station applications, strategic principles are explored which, when coupled with specific objectives for central stations, can produce a market development implementation plan. The study includes (1) background information on the National Photovoltaic Program, photovoltaic technology, and central stations; (2) a brief market assessment; (3) a discussion of the viewpoints of the electric utility industry with respect to solar energy; (4) a discussion of commercialization issues; and (5) strategy principles. It is recommended that a set of specific goals and objectives be defined for the photovoltaic central station program, and that these goals and objectives evolve into an implementation plan that identifies the appropriate federal role.

  18. Centrality and economic development in the Rijnland region: social and spatial concepts of centrality

    NARCIS (Netherlands)

    Van Nes, A.

    2007-01-01

    In urban research, spatial and social concepts of centrality are being distinguished. From a spatial point of view, metrical centrality implies that something is located in the middle of an area. However, metrical and topological centrality are not equivalent. In research where space syntax methods

  19. 中枢性嗜眠症%Hypersomnia of central origin

    Institute of Scientific and Technical Information of China (English)

    陈静; 陈贵海

    2014-01-01

    中枢性嗜眠症是在排除呼吸相关的睡眠障碍、生理节律紊乱及夜间睡眠干扰等因素后,以日间睡眠增多为首要主诉的睡眠异常。它包括发作性睡病、特发性嗜眠症、复发性嗜眠症、行为诱发的睡眠不足综合征、疾病状态相关性嗜眠症、药物相关性嗜眠症等多个睡眠障碍类型,不同程度地影响人们的生活质量乃至生命安全。其中绝大多数的发病机制均未明确。药物治疗上多侧重于促醒、兴奋等对症处理,行为治疗尤其对发作性睡病和特发性嗜眠症患者不可或缺。未来对于中枢性嗜眠症的研究需要更加致力于其发病机制以及治疗方法的探索,期待有更大样本的临床研究。%Hypersomnia of central origin,in which the primary complaint is excessive daytime sleep,is a group of sleep disorders including narcolepsy,idiopathic hypersomnia,recurrent hypersomnia,behaviorally induced insuffient sleep syndrome,hy-persomnia due to medical conditions and hypersomnia due to drug or substance intake.It is not caused by sleep-disordered breath-ing,misaligned circadian rhythms or disturbed nocturnal sleep,and can influence the quality and safety of life in certain degrees. The treatment for hypersomnia of central origin focus on stimulants and waking-promoting agents targeting at symptom improve-ment simply,for its pathogenesis is still unclear.Moreover,behavioral management can also make a significant impact,espacially for narcolepsy and idiopathic hypersomnia.In the futrue,the research of hypersomnia of central origin needs to struggle for the ex-ploration of the pathogenesis and therapy,expecting more large sample clinical researchs.

  20. 权力非意识集聚与领导决策探微%An Exploration on Unconscious Centralization and Leadership Decision-making

    Institute of Scientific and Technical Information of China (English)

    李世雄

    2013-01-01

      权力非意识集聚不仅是集权的一种形式,同时也是集权现象得以存在的核心支撑要素之一,它具有“非有意性”的本质特征,在上下级权力意识差异性、领导权威以及群体压力等因素作用下得以形成,它是集权现象持续存在并不断得到强化的根本原因,对领导决策产生重要影响。克服它对领导决策的负面影响必须从其本质特征入手,通过改善组织成员潜意识中对权力运作体系的相关认知来有效改善权力集聚的非意识形态。%The non-conscious centralization of power is not only a form of centralization but also one of key supporting elements of its existence.It has the essential characteristic of non-conscious, which is caused by the differences of superior-subordinate power consciousness, leading authority, the group pressure and so on.It is the fundamental reason for power centralization lasting and being continually strengthened.The non-conscious centralization of power has significant impact on the leadership decision -mak-ing.To overcome its negative effects , we should starting with its essential characteristic , and effectively improve the non-con-scious centralization of power through improving the related knowledge about the system of power operation in group members 'sub-conscious awareness.

  1. Application of central venous catheter in hematodialysis%中心静脉置管在血液透析中的应用

    Institute of Scientific and Technical Information of China (English)

    马樱

    2008-01-01

    Objective To approach the application and nursing strategy of central venous catheter in hematodialysis. Meth- ods Sterile operation was strictly done. The nursing of central venous catheter were strengthened. Infection of puncturation and ecchymoma were prevented. Results One hundred and thirty two patients with hematodialysis had been detained central venous catheter for 3 days to 1 months. Only 2 cases of which had infection in puncture point. Pyrogenetic reaction appeared in one case. Five patients developed phlebothrombesis, 3 had mechanical phlebophlogosis. All of above patients were cured by treat- ment. Conclusion It is a normal, safe and effect measure to detain central venous catheter in hematodialysis. The time of detain central venous catheter may be prolong by strengthening nursing, strictly operating in hematodialysis and timely changing dress- ings. Complications involving infection may be reduced.%目的 探讨中心静脉置管在血液透析中的应用和护理对策.方法 严格执行无菌操作,加强中心静脉导管留置过程中的护理,预防穿刺点感染和皮下血肿等并发症出现.结果 留置时间3 d~1个月,132例中发生穿刺点感染2例,其中出现发热反应1例,静脉血栓5例,机械性静脉炎3例,经治疗均好转.结论 中心静脉置管是血液透析最常用、安全和有效的通路,加强中心静脉留置管护理,严格透析操作,按时换药,可延长留王时间,减少感染等并发症.

  2. 优质护理在学龄前儿童急诊清创缝合中的应用效果%Application effect of quality nursing in emergency debridement and sutur-ing for preschool children

    Institute of Scientific and Technical Information of China (English)

    熊云萍

    2015-01-01

    Objective To investigate the application effect of quality nursing in the emergency debridement and sutur-ing for preschool children. Methods 100 preschool children who were hospitalized and given emergency debridement and suturing in our hospital from January 2013 to December 2014 were selected as study subjects.They were divided into control group (n=50) and observation group (n=50) according to the random method.The control group was given conventional nursing measures,the observation group was given quality nursing measures.The children’s compliance, nursing satisfaction,heart rates and respiratory situation in two groups were observed. Results In the control group,the children’s compliance rate was 10%,and the children and their families’ satisfaction to nursing service was 58%.In the observation group,the children’s compliance rate was 34%,and the children and their families’ satisfaction to nursing service was 96%.The nursing compliance and nursing satisfaction in observation group were significantly higher than those of the control group (P<0.05).After surgery,the heart rate and respiration situation in observation group were sig-nificantly better than those of the control group (P<0.05). Conclusion The application of quality nursing in the emer-gency debridement and suturing for preschool children has significant effect,can effectively improve the children’s heart rates and respiratory situation,can effectively improve the children’s treatment compliance and is conducive to patient prognosis,and meanwhile,the children and their families’ satisfaction to nursing service improve significantly,which is beneficial to promoting the harmonious development of nurse-patient relationship.%目的:探讨优质护理在学龄前儿童急诊清创缝合中的应用效果。方法选取2013年1月~2014年12月入住我院进行急诊清创缝合的100例学龄前儿童患者作为研究对象,将其随机分为对照组(n=50)和观察组(n=50)。对

  3. Elements of Poro-Elasticity for Reservoir Engineering Éléments de poro-élasticité pour l'ingénierie de réservoirs

    Directory of Open Access Journals (Sweden)

    Bouteca M.

    2006-11-01

    -élasticité utiles à l'ingénieur de réservoir. La poro-élasticité permet de calculer les déformations du solide liées au mouvement du fluide. C'est donc le cadre théorique qui permet de définir la compressibilité de la roche. Nous montrons ainsi, dans un premier temps, comment les variables mécaniques précédemment introduites sont reliées à la compressibilité de la roche mesurée expérimentalement. Deux hypothèses sont retenues : a mesure en condition isotrope (définie par une pression de confinement et une pression de pore, b mesure en condition oedométrique (définie par un chargement vertical, un déplacement radial nul et une pression de pore. Les principaux résultats sont illustrés dans le tableau 6. On montre en outre qu'en condition isotrope, la compressibilité du volume poreux peut être mesurée indifféremment à pression de pore variable et pression de confinement constante ou à pression de pore constante et pression de confinement variable (tableau 5. Dans un deuxième temps nous examinons sous quelles conditions l'équation de diffusivité définie dans la première partie peut être découplée de l'équation d'équilibre du solide. On montre que la contribution de la déformation de la roche à l'écoulement peut être exprimée à l'aide d'un coefficient de compressibilité à condition que l'on fasse des hypothèses sur le mode de déformation local de la roche. Rappelons que, par opposition à des conditions aux limites qui sont vraies sur le contour du domaine, les conditions locales sont vraies en tout point et constituent une simplification du problème réel. En conclusion, on souligne l'importance du choix des conditions locales retenues pour la mesure de la compressibilité de la roche. La compressibilité de la roche étant définie, l'équation de diffusivité prend sa forme classique : la contribution de la roche est introduite en définissant une compressibilité totale somme de la compressibilité du fluide et de celle de la roche.

  4. XNAT Central: Open sourcing imaging research data.

    Science.gov (United States)

    Herrick, Rick; Horton, William; Olsen, Timothy; McKay, Michael; Archie, Kevin A; Marcus, Daniel S

    2016-01-01

    XNAT Central is a publicly accessible medical imaging data repository based on the XNAT open-source imaging informatics platform. It hosts a wide variety of research imaging data sets. The primary motivation for creating XNAT Central was to provide a central repository to host and provide access to a wide variety of neuroimaging data. In this capacity, XNAT Central hosts a number of data sets from research labs and investigative efforts from around the world, including the OASIS Brains imaging studies, the NUSDAST study of schizophrenia, and more. Over time, XNAT Central has expanded to include imaging data from many different fields of research, including oncology, orthopedics, cardiology, and animal studies, but continues to emphasize neuroimaging data. Through the use of XNAT's DICOM metadata extraction capabilities, XNAT Central provides a searchable repository of imaging data that can be referenced by groups, labs, or individuals working in many different areas of research. The future development of XNAT Central will be geared towards greater ease of use as a reference library of heterogeneous neuroimaging data and associated synthetic data. It will also become a tool for making data available supporting published research and academic articles.

  5. Betweenness Centrality in Some Classes of Graphs

    Directory of Open Access Journals (Sweden)

    Sunil Kumar Raghavan Unnithan

    2014-01-01

    Full Text Available There are several centrality measures that have been introduced and studied for real-world networks. They account for the different vertex characteristics that permit them to be ranked in order of importance in the network. Betweenness centrality is a measure of the influence of a vertex over the flow of information between every pair of vertices under the assumption that information primarily flows over the shortest paths between them. In this paper we present betweenness centrality of some important classes of graphs.

  6. Central Serous Chorioretinopathy after Solar Eclipse Viewing

    Directory of Open Access Journals (Sweden)

    Allie Lee

    2010-01-01

    Full Text Available Purpose: To report a case of central serous chorioretinopathy after solar eclipse viewing. Case Report: A middle-age man developed a sudden-onset unilateral scotoma after viewing a partial solar eclipse in Hong Kong. Fundus examination, fluorescein angiography, and optical coherence tomography showed features compatible with central serous chorioretinopathy. The patient was managed conservatively and reevaluated periodically. Serial optical coherence tomographic evaluations demonstrated an initial increase in the amount of subretinal fluid which spontaneously resolved 10 weeks after the onset of symptoms. Conclusion: This case demonstrates the possibility of development of central serous chorioretinopathy following solar eclipse viewing.

  7. [Functional anatomy of the central nervous system].

    Science.gov (United States)

    Krainik, A; Feydy, A; Colombani, J M; Hélias, A; Menu, Y

    2003-03-01

    The central nervous system (CNS) has a particular regional functional anatomy. The morphological support of cognitive functions can now be depicted using functional imaging. Lesions of the central nervous system may be responsible of specific symptoms based on their location. Current neuroimaging techniques are able to show and locate precisely macroscopic lesions. Therefore, the knowledge of functional anatomy of the central nervous system is useful to link clinical disorders to symptomatic lesions. Using radio-clinical cases, we present the functional neuro-anatomy related to common cognitive impairments.

  8. Central black hole masses of galaxies

    Institute of Scientific and Technical Information of China (English)

    樊军辉

    2003-01-01

    In this paper, the stellar velocity dispersions in the host galaxies are used to estimate the central black hole masses for a sample of elliptical galaxies. We find that the central black hole masses are in the range of 10(5.5-9.5) M(○). Based on the estimated masses in this paper and those by Woo & Urry (2002) and the measured host galaxy absolute magnitude,a relation, log(MBH/M(○)) = -(0.25 ± 4.3 × 10-3)MR + (2.98 4 0.208) is found for central black hole mass and the host galaxy magnitude. Some discussions are presented.

  9. Erroneous laboratory values obtained from central catheters.

    Science.gov (United States)

    Johnston, J B; Messina, M

    1991-01-01

    Serious analytic errors in potassium measurements have been identified in blood specimens obtained from newly inserted central catheters. Erroneous elevated readings have been related to interactions of chemistry analyzer electrodes and substances fixed to external and intraluminal walls of the central catheter. Anecdotal summaries of this phenomenon are presented to enable the nurse to recognize potential problems when sampling blood from central catheters. Studies were performed to determine the amount of flush necessary to clear the catheter of interfering residue. To eliminate this potentially hazardous occurrence, recommended flush volumes, nursing implications, and actions are described.

  10. Genetics Home Reference: central precocious puberty

    Science.gov (United States)

    ... difference in gene activation is caused by a phenomenon called genomic imprinting. Because only the copy of ... cause the disorder. When passed from parent to child, the condition is known as familial central precocious ...

  11. 1999 Yellow River Aerial Photos, Central Wisconsin

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The 25-mile stretch of the Yellow River adjacent to the Necedah National Wildlife Refuge in Central Wisconsin provides valuable habitat to numerous species of...

  12. Red wine, arterial stiffness and central hemodynamics.

    Science.gov (United States)

    Karatzi, Kalliopi; Papaioannou, Theodore G; Papamichael, Christos; Lekakis, John; Stefanadis, Christodoulos; Zampelas, Antonis

    2009-01-01

    Red wine is considered to reduce cardiovascular risk and decrease peripheral systolic and diastolic blood pressure. Central aortic pressures are often more sensitive clinical and prognostic factors than peripheral pressures, while arterial stiffness is an independent prognostic factor for cardiovascular events. Great efforts are being made to find natural sources of improving health. In order to clarify the mechanisms under which a widely used drink, like red wine, is affecting heart and vessels, we aimed to review the available data regarding the effects of red wine on arterial stiffness, wave reflections and central blood pressures. The effect of red wine on central hemodynamics has been poorly explored with divergent results. Possible consequences of acute and long-term intake on arterial stiffness, wave reflections and central pressures are not clear. This might make someone skeptical when suggesting the consumption of a glass of red wine, although its cardioprotective actions (when moderately consumed) are already shown from epidemiological studies.

  13. NCI Central Review Board Receives Accreditation

    Science.gov (United States)

    The Association for the Accreditation of Human Research Protection Programs has awarded the NCI Central Institutional Review Board full accreditation. AAHRPP awards accreditation to organizations demonstrating the highest ethical standards in clinical res

  14. Random walk centrality in interconnected multilayer networks

    CERN Document Server

    Solé-Ribalta, Albert; Gómez, Sergio; Arenas, Alex

    2015-01-01

    Real-world complex systems exhibit multiple levels of relationships. In many cases they require to be modeled as interconnected multilayer networks, characterizing interactions of several types simultaneously. It is of crucial importance in many fields, from economics to biology and from urban planning to social sciences, to identify the most (or the less) influential nodes in a network using centrality measures. However, defining the centrality of actors in interconnected complex networks is not trivial. In this paper, we rely on the tensorial formalism recently proposed to characterize and investigate this kind of complex topologies, and extend two well known random walk centrality measures, the random walk betweenness and closeness centrality, to interconnected multilayer networks. For each of the measures we provide analytical expressions that completely agree with numerically results.

  15. Central Gulf of Alaska Rockfish Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The North Pacific Fishery Management Council adopted the Central Gulf of Alaska Rockfish Program (Rockfish Program) on June 14, 2010, to replace the expiring Pilot...

  16. California Black Rail - Central Delta [ds17

    Data.gov (United States)

    California Department of Resources — Results of taped-call black rail surveys of in-stream habitat within certain waterways in the central Sacramento / San Joaquin Delta during 1992 and 1993. TIME...

  17. Central Asian Snow Cover from Hydrometeorological Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Central Asian Snow Cover from Hydrometeorological Surveys data are based on observations made by personnel for three river basins: Amu Darya, Sir Darya, and...

  18. Legume Diversity Patterns in West Central Africa

    NARCIS (Netherlands)

    Estrella, de la M.; Mateo, M.A.; Wieringa, J.J.; Mackinder, B.; Munoz, J.

    2012-01-01

    Objectives - Species Distribution Models (SDMs) are used to produce predictions of potential Leguminosae diversity in West Central Africa. Those predictions are evaluated subsequently using expert opinion. The established methodology of combining all SDMs is refined to assess species diversity withi

  19. Childhood Central Nervous System Embryonal Tumors Treatment

    Science.gov (United States)

    ... Cord Tumors Treatment Childhood Astrocytomas Treatment Childhood Brain Stem Glioma ... Central nervous system (CNS) embryonal tumors may begin in embryonic (fetal) cells that remain in the brain after birth. ...

  20. NCPC Central Files Information System (CFIS)

    Data.gov (United States)

    National Capital Planning Commission — This dataset contains records from NCPC's Central Files Information System (CFIS), which is a comprehensive database of projects submitted to NCPC for design review...

  1. Central respiratory failure during acute organophosphate poisoning.

    Science.gov (United States)

    Carey, Jennifer L; Dunn, Courtney; Gaspari, Romolo J

    2013-11-01

    Organophosphate (OP) pesticide poisoning is a global health problem with over 250,000 deaths per year. OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Mortality due to OP agents is attributed to respiratory dysfunction, including central apnea. Cholinergic circuits are integral to many aspects of the central control of respiration, however it is unclear which mechanisms predominate during acute OP intoxication. A more complete understanding of the cholinergic aspects of both respiratory control as well as neural modification of pulmonary function is needed to better understand OP-induced respiratory dysfunction. In this article, we review the physiologic mechanisms of acute OP exposure in the context of the known cholinergic contributions to the central control of respiration. We also discuss the potential central cholinergic contributions to the known peripheral physiologic effects of OP intoxication.

  2. Alluvial Boundary of California's Central Valley

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This digital dataset defines the extent of the alluvial deposits in the Central Valley of California and encompasses the contiguous Sacramento, San Joaquin, and...

  3. Shattering and Compressing Networks for Centrality Analysis

    CERN Document Server

    Sarıyüce, Ahmet Erdem; Kaya, Kamer; Çatalyürek, Ümit V

    2012-01-01

    Who is more important in a network? Who controls the flow between the nodes or whose contribution is significant for connections? Centrality metrics play an important role while answering these questions. The betweenness metric is useful for network analysis and implemented in various tools. Since it is one of the most computationally expensive kernels in graph mining, several techniques have been proposed for fast computation of betweenness centrality. In this work, we propose and investigate techniques which compress a network and shatter it into pieces so that the rest of the computation can be handled independently for each piece. Although we designed and tuned the shattering process for betweenness, it can be adapted for other centrality metrics in a straightforward manner. Experimental results show that the proposed techniques can be a great arsenal to reduce the centrality computation time for various types of networks.

  4. Earthquakes in Central California, 1980-1984

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — There have been many earthquake occurrences in central California. This set of slides shows earthquake damage from the following events: Livermore, 1980, Coalinga,...

  5. Veterans Affairs Central Cancer Registry (VACCR)

    Data.gov (United States)

    Department of Veterans Affairs — The Veterans Affairs Central Cancer Registry (VACCR) receives and stores information on cancer diagnosis and treatment constraints compiled and sent in by the local...

  6. Miniaturized Airborne Imaging Central Server System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance-computer-based electronic backend that...

  7. Miniaturized Airborne Imaging Central Server System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance computer-based electronic backend that...

  8. Central Bank Transparency: Causes, Consequences and Updates

    OpenAIRE

    Nergiz Dincer; Barry Eichengreen

    2009-01-01

    We present updated estimates of central bank for 100 countries up through 2006 and use them to analyze both the determinants and consequences of monetary policy transparency in an integrated econometric framework. We establish that there has been significant movement in the direction of greater central bank transparency in recent years. Transparent monetary policy arrangements are more likely in countries with strong and stable political institutions. They are more likely in democracies, with...

  9. Economic Dimensions of Security in Central Asia

    Science.gov (United States)

    2006-01-01

    dollars worth of illegal or unregistered cash, most of it associated with narcotics trafficking and unreported remittances from migrant labor , is...Economic Dimensions of Security in Central Asia month on some construction sites.32 Remittances from legal migrant labor are part of the Central Asian...farms and construction sites,36 since they rarely have any le- gal standing. Also, income from migrant labor is usually barely suffi- cient to cover

  10. "Shadow Banking: Policy Challenges for Central Banks"

    OpenAIRE

    Moe, Thorvald Grung

    2014-01-01

    Central banks responded with exceptional liquidity support during the financial crisis to prevent a systemic meltdown. They broadened their tool kit and extended liquidity support to nonbanks and key financial markets. Many want central banks to embrace this expanded role as "market maker of last resort" going forward. This would provide a liquidity backstop for systemically important markets and the shadow banking system that is deeply integrated with these markets. But how much liquidity su...

  11. Central odontogenic fibroma of the simple type

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Eui Hwan; Lee, Sang Rae [Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University, Seoul (Korea, Republic of)

    2002-12-15

    The central odontogenic fibroma is a rare benign neoplasm, and considered to be derived from the mesenchymal tissue of dental origin. It is a poorly defined tumor of the jawbones which has only been infrequently reported in the literature. We report a histologically proven case of simple-type central odontogenic fibroma, which affected the left canine-premolar region of the maxilla in a 52-year-old woman.

  12. Entrapment of guidewire during central venous catheterization

    Directory of Open Access Journals (Sweden)

    Tarun S.

    2016-07-01

    Full Text Available Central venous catheterization (CVC is common in the setting of ICU for various reasons like monitoring of CVP, fluid administration and vasopressor or drug infusions. Guidewires are routinely used in the Seldinger technique during central venous catheter placement CVC placement is not innocuous as numerous complications may occur, with varying frequency and severity. [Int J Res Med Sci 2016; 4(7.000: 3080-3081

  13. A handbook for solar central receiver design

    Energy Technology Data Exchange (ETDEWEB)

    Falcone, P.K.

    1986-12-01

    This Handbook describes central receiver technology for solar thermal power plants. It contains a description and assessment of the major components in a central receiver system configured for utility scale production of electricity using Rankine-cycle steam turbines. It also describes procedures to size and optimize a plant and discussed examples from recent system analyses. Information concerning site selection criteria, cost estimation, construction, and operation and maintenance is also included, which should enable readers to perform design analyses for specific applications.

  14. Midwifery education in Central-Eastern Europe.

    Science.gov (United States)

    Mivšek, Polona; Baškova, Martina; Wilhelmova, Radka

    2016-02-01

    Problems in midwifery in many Central-Eastern European countries are very similar; it is possible to speak about the evolving Central-Eastern model of midwifery care. The educational models of this region have a relatively strong theoretical part; however, there is an insufficient practical dimension. Theoretical part of midwifery education in the universities is relatively autonomous and is slowly changing the professional identity of graduates.

  15. Central Hemodynamics and Microcirculation in Critical Conditions

    Directory of Open Access Journals (Sweden)

    A. A. Kosovskikh

    2013-01-01

    Full Text Available Objective: to compare central hemodynamic and microcirculatory changes in critical conditions caused by different factors and to reveal their possible differences for a further differentiated approach to intensive therapy. Subjects and methods. The study covered 16 subjects with severe concomitant injury (mean age 41.96±2.83 years and 19 patients with general purulent peritonitis (mean age 45.34±2.16 years. Their follow-up was 7 days. The central hemodynamics was estimated by transpulmonary thermodilution using a Pulsion PiCCO Plus system (Pulsion Medical Systems, Germany. The microcirculatory bed was evaluated by cutaneous laser Doppler flowmetry using a LAKK-02 capillary blood flow laser analyzer (LAZMA Research-and-Production Association, Russian Federation. Results. The pattern of central hemodynamic and microcirculatory disorders varies with the trigger that has led to a critical condition. Central hemodynamics should be stabilized to ensure the average level of tissue perfusion in victims with severe concomitant injury. In general purulent peritonitis, microcirculatory disorders may persist even if the macrohemodynamic parameters are normal. Conclusion. The macrohemodynamic and microcirculatory differences obtained during the study suggest that a complex of intensive therapy should be differentiated and, if the latter is used, it is necessary not only to be based on the central hemodynamics, but also to take into consideration functional changes in microcirculation. Key words: severe concomitant injury, general purulent peritonitis, micro-circulation, central hemodynamics, type of circulation.

  16. Fast network centrality analysis using GPUs

    Directory of Open Access Journals (Sweden)

    Shi Zhiao

    2011-05-01

    Full Text Available Abstract Background With the exploding volume of data generated by continuously evolving high-throughput technologies, biological network analysis problems are growing larger in scale and craving for more computational power. General Purpose computation on Graphics Processing Units (GPGPU provides a cost-effective technology for the study of large-scale biological networks. Designing algorithms that maximize data parallelism is the key in leveraging the power of GPUs. Results We proposed an efficient data parallel formulation of the All-Pairs Shortest Path problem, which is the key component for shortest path-based centrality computation. A betweenness centrality algorithm built upon this formulation was developed and benchmarked against the most recent GPU-based algorithm. Speedup between 11 to 19% was observed in various simulated scale-free networks. We further designed three algorithms based on this core component to compute closeness centrality, eccentricity centrality and stress centrality. To make all these algorithms available to the research community, we developed a software package gpu-fan (GPU-based Fast Analysis of Networks for CUDA enabled GPUs. Speedup of 10-50× compared with CPU implementations was observed for simulated scale-free networks and real world biological networks. Conclusions gpu-fan provides a significant performance improvement for centrality computation in large-scale networks. Source code is available under the GNU Public License (GPL at http://bioinfo.vanderbilt.edu/gpu-fan/.

  17. Central auditory function of deafness genes.

    Science.gov (United States)

    Willaredt, Marc A; Ebbers, Lena; Nothwang, Hans Gerd

    2014-06-01

    The highly variable benefit of hearing devices is a serious challenge in auditory rehabilitation. Various factors contribute to this phenomenon such as the diversity in ear defects, the different extent of auditory nerve hypoplasia, the age of intervention, and cognitive abilities. Recent analyses indicate that, in addition, central auditory functions of deafness genes have to be considered in this context. Since reduced neuronal activity acts as the common denominator in deafness, it is widely assumed that peripheral deafness influences development and function of the central auditory system in a stereotypical manner. However, functional characterization of transgenic mice with mutated deafness genes demonstrated gene-specific abnormalities in the central auditory system as well. A frequent function of deafness genes in the central auditory system is supported by a genome-wide expression study that revealed significant enrichment of these genes in the transcriptome of the auditory brainstem compared to the entire brain. Here, we will summarize current knowledge of the diverse central auditory functions of deafness genes. We furthermore propose the intimately interwoven gene regulatory networks governing development of the otic placode and the hindbrain as a mechanistic explanation for the widespread expression of these genes beyond the cochlea. We conclude that better knowledge of central auditory dysfunction caused by genetic alterations in deafness genes is required. In combination with improved genetic diagnostics becoming currently available through novel sequencing technologies, this information will likely contribute to better outcome prediction of hearing devices.

  18. Dynamics-based centrality for directed networks

    Science.gov (United States)

    Masuda, Naoki; Kori, Hiroshi

    2010-11-01

    Determining the relative importance of nodes in directed networks is important in, for example, ranking websites, publications, and sports teams, and for understanding signal flows in systems biology. A prevailing centrality measure in this respect is the PageRank. In this work, we focus on another class of centrality derived from the Laplacian of the network. We extend the Laplacian-based centrality, which has mainly been applied to strongly connected networks, to the case of general directed networks such that we can quantitatively compare arbitrary nodes. Toward this end, we adopt the idea used in the PageRank to introduce global connectivity between all the pairs of nodes with a certain strength. Numerical simulations are carried out on some networks. We also offer interpretations of the Laplacian-based centrality for general directed networks in terms of various dynamical and structural properties of networks. Importantly, the Laplacian-based centrality defined as the stationary density of the continuous-time random walk with random jumps is shown to be equivalent to the absorption probability of the random walk with sinks at each node but without random jumps. Similarly, the proposed centrality represents the importance of nodes in dynamics on the original network supplied with sinks but not with random jumps.

  19. Community centrality and social science research.

    Science.gov (United States)

    Allman, Dan

    2015-12-01

    Community centrality is a growing requirement of social science. The field's research practices are increasingly expected to conform to prescribed relationships with the people studied. Expectations about community centrality influence scholarly activities. These expectations can pressure social scientists to adhere to models of community involvement that are immediate and that include community-based co-investigators, advisory boards, and liaisons. In this context, disregarding community centrality can be interpreted as failure. This paper considers evolving norms about the centrality of community in social science. It problematises community inclusion and discusses concerns about the impact of community centrality on incremental theory development, academic integrity, freedom of speech, and the value of liberal versus communitarian knowledge. Through the application of a constructivist approach, this paper argues that social science in which community is omitted or on the periphery is not failed science, because not all social science requires a community base to make a genuine and valuable contribution. The utility of community centrality is not necessarily universal across all social science pursuits. The practices of knowing within social science disciplines may be difficult to transfer to a community. These practices of knowing require degrees of specialisation and interest that not all communities may want or have.

  20. Health challenges in Kazakhstan and Central Asia.

    Science.gov (United States)

    Adambekov, Shalkar; Kaiyrlykyzy, Aiym; Igissinov, Nurbek; Linkov, Faina

    2016-01-01

    The Central Asian region, which encompasses Kazakhstan, Uzbekistan, Tajikistan, Turkmenistan and Kyrgyzstan, is an interesting geographic region with a rich history dating back to the Silk Road, Mongol conquests and expansion of the Russian Empire. However, from a public health viewpoint, the Central Asian region is under-investigated, and many public health challenges exist, as countries of Central Asia inherited the centralised medical systems practiced in the Soviet Union, and are currently undergoing rapid transitions. A large number of low and middle-income countries around the world, including countries of Central Asia, face a double burden of chronic and infectious disease. This essay focuses on the exploration of the most important public health challenges in the Central Asian region, including limited scientific productivity, the double burden of chronic and infectious disease, the need for healthcare reform and the reduction in care variation. Central Asia has a large number of medical schools, medical centres, and emerging research institutes that can be used to foster a change in medical and public health practice in the region.

  1. Determinants of Central Adiposity among Iranian Population

    Directory of Open Access Journals (Sweden)

    Leila Azadbakht

    2013-03-01

    Full Text Available Background: Central obesity is one of the major public health problems. Recent studies have indicated that body fat distribution would be important in general health. Materials and Methods: The present study is a review of several studies which discuss the contributing factors of abdominal obesity, particulary in Iran. This study reviews 34 cross-sectional and interventional studies, which have been comducted during 1995-2012 and issued in English language. PubMed search engine and the related keywords were used to search the papers.Results: Breakfast skipping and also the sleep duration as well as the quality of diet are also associated with central adiposity. Dietary diversity score among Iranians can be related to abdominal adiposity. Fastfood consumption can increase the risk of central adiposity among young Iranian population. Red meat intake and food source of trans fat can increase the risk of central adiposity. Low quality diet with low amount of nutrients can increase the risk of central adiposity. Conclusion: Some behaviours such as sleep duration and eating breakfast can be associated with central adiposity among Iranians. Diet quality and dietary diversity score is also associated with this problem among Iranians.

  2. GLOBAL FINANCIAL CRISIS AND UNIT-LINKED INSURANCE MARKETS EFFICIENCY: EMPIRICAL EVIDENCE FROM CENTRAL AND EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Botoş Horia Mircea

    2012-12-01

    Full Text Available This paper empirically investigates the impact of the Global financial crisis on the efficiency of four Central and Eastern European emerging unit-linked insurance markets, applying the automatic variance ratio (AVR test of Kim (2009 and variance ratio tests using ranks and signs by Wright (2000 for entire, pre-crisis and crisis periods. This study contributes to the existing literature on efficient market hypothesis with several distinct features: it provides a systematic review of the weak-form market efficiency literature that examines return predictability of the daily ING unit-linked funds prices; also the article aims at monitoring any improvement in the degree of efficiency in time and also examines the relative efficiency of unit-linked insurance markets in pre-crisis and crisis periods. Unit linked insurance are life insurance policies with investment component. In the literature there are few studies investigating the effects of a financial crisis on the potential of predictability and implicitly on the degree of efficiency of financial markets. The occurrence of a market crash or financial crisis is a possible contributing factor of market inefficiency. Most of the studies are focused on the Asian crisis in 1997: Holden et al. (2005 examined the weak-form efficiency of eight emerging Asian stock markets using VR tests before, during and after the Asian crisis; Kim and Shamsuddin (2008 used three different types of multiple VR tests for nine Asian stock markets; the findings reported by Lim et al. (2008 are consistent with those reported by Cheong et al. (2007, in which the highest inefficiency occurs during the crisis period. Todea and Lazar (2010 investigated the effects of the Global crisis on the relative efficiency of ten CEE stock markets, using Generalized Spectral test of Escanciano and Velasco (2006. Wright (2000 proposes the alternative non-parametric variance ratio tests using ranks and signs of return and demonstrates that

  3. 京津冀基本公共服务差距、成因及对策%The Basic Public Service Gap,Causes and Countermeasures between Beij ing-Tianj in-Hebei Region

    Institute of Scientific and Technical Information of China (English)

    王延杰; 冉希

    2016-01-01

    在概括分析京津冀基本公共服务差距的基础上,认为公共服务领域的财力、人力和物力资源配置失衡以及较低的财税体制调控能力,是造成京津冀基本公共服务断崖式落差,阻碍京津冀协同发展的重要原因。缩小京津冀基本公共服务差距,推进京津冀基本公共服务均等化,必须深化财税体制改革,厘清中央与地方事权与支出责任关系,完善中央对地方收入划分与财力调节体制,完善跨区投资税收分享机制与区域生态补偿机制,加强京津冀财政协同合作与公共服务项目合作。%Based on the summarization and analysis of basic public service gap between Beijing,Tianjin and Hebei,this paper points out that the imbalanced allocation of financial resources,manpower and material resources in the public service field,together with the poor ability in regulating and controlling fiscal and taxation system lead to a cliff gap of Beijing,Tianjin and Hebei basic public service,hindering the coordinated development of this area.To narrow the basic public service gap of Beijing,Tianjin and Hebei,and promote the equitable access to basic public service in this area,we must deepen the reform of the finance and taxation system,clarify the relationship between the central and local governments in powers as well as expenditure responsibilities,complete the income division system as well as the finan-cial regulation system between the central government and local government;we also have to improve the tax sharing mechanism of cross-district investment and the regional ecological compensation mecha-nism,and strengthen the financial cooperation and public service projects cooperation of Beijing,Tian-jin and Hebei.

  4. Conductividad, oxígeno disuelto, PH y temperatura en el rio bermudez (Costa Rica y su relación con el uso del suelo en la cuenca (ING

    Directory of Open Access Journals (Sweden)

    Leda Castro

    2016-03-01

    Full Text Available Se examinaron los patrones de variación espacial y temporal de la conductividad, el oxígeno disuelto, el pH y la temperatura en el río Bermúdez, Valle Central, Costa Rica, durante un período de 28 meses. El uso de la tierra más común en la cuenca es el cultivo del café (53%, seguido por el uso urbano (30%, el cual aumenta conforme se desciende hacia el piso del Valle. Si bien las aguas presentan una buena calidad en el área cercana a su origen, donde el uso de la tierra que predomina corresponde a bosque o pastos, a menudo protegidos por medio de parques recreativos, el río sufre un progresivo deterioro conforme desciende y sus aguas se tornan inadecuadas para consumo humano y peligrosas para la salud de las habitantes de la cuenca. La conductividad, el pH y el oxígeno disuelto varían estacionalmente en relación con el régimen de precipitación y el aporte de las aguas de desecho. El río Bermúdez puede considerarse representativo de los ríos del Valle Central. El deterioro de sus aguas ha hecho perder mucho de su atractivo escénico, y el río no puede ser utilizado como fuente de agua potable, ni para actividades agrícolas o recreativas. Los factores contaminantes persisten pues no se ha implementado un manejo adecuado de las aguas negras, no se ha puesto en práctica la legislación existente y vigente para obligar a las industrias a disminuir la contaminación provocada por sus efluentes, y por último, la contaminación orgánica proveniente del beneficiado del café, si bien ha disminuido por la puesta en marcha de políticas institucionales con este fin, continúa siendo de gran magnitud. Las aguas del río continúan siendo utilizadas para irrigar cultivos de hortalizas en la parte baja del río, lo que representa un peligro para la salud humana.

  5. Market Information and Signaling in Central Bank Operations, or, How Often Should a Central Bank Intervene?

    OpenAIRE

    International Monetary Fund

    1997-01-01

    A central bank must decide on the frequency with which it will conduct open market operations and the variability in short-term money market that it will allow. The paper shows how the optimal operating procedure balances the value of attaining an immediate target and broadcasting the central bank's intentions against the informational advantages to the central bank of allowing the free play of market forces to reveal more of the information available to market participants.

  6. Central nervous system complications after liver transplantation.

    Science.gov (United States)

    Kim, Jeong-Min; Jung, Keun-Hwa; Lee, Soon-Tae; Chu, Kon; Roh, Jae-Kyu

    2015-08-01

    We investigated the diversity of central nervous system complications after liver transplantation in terms of clinical manifestations and temporal course. Liver transplantation is a lifesaving option for end stage liver disease patients but post-transplantation neurologic complications can hamper recovery. Between 1 January 2001 and 31 December 2010, patients who had undergone liver transplantation at a single tertiary university hospital were included. We reviewed their medical records and brain imaging data and classified central nervous system complications into four categories including vascular, metabolic, infectious and neoplastic. The onset of central nervous system complications was grouped into five post-transplantation intervals including acute (within 1 month), early subacute (1-3 months), late subacute (3-12 months), chronic (1-3 years), and long-term (after 3 years). During follow-up, 65 of 791 patients (8.2%) experienced central nervous system complications, with 30 occurring within 1 month after transplantation. Vascular etiology was the most common (27 patients; 41.5%), followed by metabolic (23; 35.4%), infectious (nine patients; 13.8%), and neoplastic (six patients). Metabolic encephalopathy with altered consciousness was the most common etiology during the acute period, followed by vascular disorders. An initial focal neurologic deficit was detected in vascular and neoplastic complications, whereas metabolic and infectious etiologies presented with non-focal symptoms. Our study shows that the etiology of central nervous system complications after liver transplantation changes over time, and initial symptoms can help to predict etiology.

  7. Dry needling - peripheral and central considerations.

    Science.gov (United States)

    Dommerholt, Jan

    2011-11-01

    Dry needling is a common treatment technique in orthopedic manual physical therapy. Although various dry needling approaches exist, the more common and best supported approach targets myofascial trigger points. This article aims to place trigger point dry needling within the context of pain sciences. From a pain science perspective, trigger points are constant sources of peripheral nociceptive input leading to peripheral and central sensitization. Dry needling cannot only reverse some aspects of central sensitization, it reduces local and referred pain, improves range of motion and muscle activation pattern, and alters the chemical environment of trigger points. Trigger point dry needling should be based on a thorough understanding of the scientific background of trigger points, the differences and similarities between active and latent trigger points, motor adaptation, and central sensitize application. Several outcome studies are included, as well as comments on dry needling and acupuncture.

  8. Retail Market Structure Development in Central Europe

    Directory of Open Access Journals (Sweden)

    Martin Machek

    2012-12-01

    Full Text Available This article is analyzing the trends and development in the retailing sector in Central Europe, namely in the Czech Republic, Hungary, Poland and Slovakia. These markets serve about 63 million inhabitants. The retail industry in Central Europe has changed dramatically in the last two decades, and has become a model for successful transformation of emerging markets. The retail market is highly concentrated and dominated by Western European retail chains. International retail chains are using all formats of modern distribution. This article is focusing on the development of hypermarkets, supermarkets and discount stores. Due to the international retail chains, Central European countries benefit from a dense network of modern shopping places; the intense competition of highly productive retailers contributes to the lower level of inflation rate because of the so-called Wal-Mart Effect. The constant pressure on prices influences the marketing strategies of both retailers and suppliers.

  9. Centralized rehabilitation after servere traumatic brain injury

    DEFF Research Database (Denmark)

    Engberg, Aase Worså; Liebach, Annette; Nordenbo, Annette Mosbæk

    2006-01-01

    OBJECTIVES: To present results from the first 3 years of centralized subacute rehabilitation after very severe traumatic brain injury (TBI), and to compare results of centralized versus decentralized rehabilitation. MATERIAL AND METHODS: Prospectively, the most severely injured group of adults from...... an uptake area of 2.4 million in Denmark were included at admission to a regional brain injury unit (BIU), on average 19 days after injury. Patients in the retrospective study used for comparison were randomly chosen from the national hospital register. RESULTS AND CONCLUSIONS: Out of 117 patients...... post-trauma was 0.29, and at 1 year 0.055 per 100,000 population. By comparison of 39 patients from the centralized unit injured in 2000-2003 with 21 patients injured in 1982, 1987 or 1992 and with similar PTA- and age distributions and male/female ratio, Glasgow Outcome Scale score at discharge...

  10. Angiotensin II during Experimentally Simulated Central Hypovolemia

    DEFF Research Database (Denmark)

    Jensen, Theo Walther; Olsen, Niels Vidiendal

    2016-01-01

    Central hypovolemia, defined as diminished blood volume in the heart and pulmonary vascular bed, is still an unresolved problem from a therapeutic point of view. The development of pharmaceutical agents targeted at specific angiotensin II receptors, such as the non-peptidergic AT2-receptor agonist...... of these agents in a hypovolemic setting. We argue that the latest debates on the effect of angiotensin II during hypovolemia might guide for future studies, investigating the effect of such agents during experimentally simulated central hypovolemia. The purpose of this review is to examine the role...... of angiotensin II during episodes of central hypovolemia. To examine this, we reviewed results from studies with three experimental models of simulated hypovolemia: head up tilt table test, lower body negative pressure, and hemorrhage of animals. A systemic literature search was made with the use of Pub...

  11. Central pain: definition, phisiopathology and therapy

    Directory of Open Access Journals (Sweden)

    Vincenzo Moschini

    2012-12-01

    Full Text Available Central pain is the expression of an injury and/or a primary or secondary dysfunction of the central nervous system.1 It is based on total or partial damage along the spinal-thalamic-cortical pathways and it may have cerebral or spinal origin. It has variable incidence according to its etiology: 8-10% in stroke patients, 30% in multiple sclerosis patients, 30-60% in paraplegic patients.2-3 At the spinal level, the most frequent causes are: traumatic injuries, cancer, plaques from multiple sclerosis, syringomyelia. In this review, we examine the main symptoms that contribute to confirm the diagnosis of central pain, neuropathic or thalamic. The presence of nerve injury, evaluated by neuroimaging and neurophysiological tests, allows us to complete the diagnostic picture.

  12. Generation of central exclusive final states

    CERN Document Server

    Lönnblad, Leif

    2016-01-01

    We present a scheme for the generation of central exclusive final states in the Pythia 8 program. The implementation allows for the investigation of higher order corrections to such exclusive processes as approximated by the initial-state parton shower in Pythia 8. To achieve this, the spin and colour decomposition of the initial-state shower has been worked out, in order to determine the probability that a partonic state generated from an inclusive sub-process followed by a series of initial-state parton splittings can be considered as an approximation of an exclusive colour- and spin-singlet process. We use our implementation to investigate effects of parton showers on some examples of central exclusive processes, and find sizeable effects on di-jet production, while the effects on e.g. central exclusive Higgs production are minor.

  13. Smart electromechanical systems the central nervous system

    CERN Document Server

    Kurbanov, Vugar

    2017-01-01

    This book describes approaches to solving the problems of developing the central nervous system of robots (CNSR) based on smart electromechanical systems (SEMS) modules, principles of construction of the various modules of the central nervous system and variants of mathematical software CNSR in control systems for intelligent robots. It presents the latest advances in theory and practice at the Russian Academy of Sciences. Developers of intelligent robots to solve modern problems in robotics are increasingly addressing the use of the bionic approach to create robots that mimic the complexity and adaptability of biological systems. These have smart electromechanical system (SEMS), which are used in various cyber-physical systems (CPhS), and allow the functions of calculation, control, communications, information storage, monitoring, measurement and control of parameters and environmental parameters to be integrated. The behavior of such systems is based on the information received from the central nervous syst...

  14. Centralized rehabilitation after servere traumatic brain injury

    DEFF Research Database (Denmark)

    Engberg, Aase Worså; Liebach, Annette; Nordenbo, Annette Mosbæk

    2006-01-01

    post-trauma was 0.29, and at 1 year 0.055 per 100,000 population. By comparison of 39 patients from the centralized unit injured in 2000-2003 with 21 patients injured in 1982, 1987 or 1992 and with similar PTA- and age distributions and male/female ratio, Glasgow Outcome Scale score at discharge......OBJECTIVES: To present results from the first 3 years of centralized subacute rehabilitation after very severe traumatic brain injury (TBI), and to compare results of centralized versus decentralized rehabilitation. MATERIAL AND METHODS: Prospectively, the most severely injured group of adults from...... an uptake area of 2.4 million in Denmark were included at admission to a regional brain injury unit (BIU), on average 19 days after injury. Patients in the retrospective study used for comparison were randomly chosen from the national hospital register. RESULTS AND CONCLUSIONS: Out of 117 patients...

  15. Central Venous Catheter-Related Hydrothorax

    Directory of Open Access Journals (Sweden)

    Se Hun Kim

    2015-11-01

    Full Text Available This report describes a case of 88-year-old women who developed central venous catheter-related bilateral hydrothorax, in which left pleural effusion, while right pleural effusion was being drained. The drainage prevented accumulation of fluid in the right pleural space, indicating that there was neither extravasation of infusion fluid nor connection between the two pleural cavities. The only explanation for bilateral hydrothorax in this case is lymphatic connections. Although vascular injuries by central venous catheter can cause catheter-related hydrothorax, it is most likely that the positioning of the tip of central venous catheter within the lymphatic duct opening in the right sub-clavian-jugular confluence or superior vena cava causes the catheter-related hydrothorax. Pericardial effusion can also result from retrograde lymphatic flow through the pulmonary lymphatic chains.

  16. Hydrogels for central nervous system therapeutic strategies.

    Science.gov (United States)

    Russo, Teresa; Tunesi, Marta; Giordano, Carmen; Gloria, Antonio; Ambrosio, Luigi

    2015-12-01

    The central nervous system shows a limited regenerative capacity, and injuries or diseases, such as those in the spinal, brain and retina, are a great problem since current therapies seem to be unable to achieve good results in terms of significant functional recovery. Different promising therapies have been suggested, the aim being to restore at least some of the lost functions. The current review deals with the use of hydrogels in developing advanced devices for central nervous system therapeutic strategies. Several approaches, involving cell-based therapy, delivery of bioactive molecules and nanoparticle-based drug delivery, will be first reviewed. Finally, some examples of injectable hydrogels for the delivery of bioactive molecules in central nervous system will be reported, and the key features as well as the basic principles in designing multifunctional devices will be described.

  17. Central functions of the orexinergic system

    Institute of Scientific and Technical Information of China (English)

    Xiao-Yang Zhang; Lei Yu; Qian-Xing Zhuang; Jing-Ning Zhu; Jian-Jun Wang

    2013-01-01

    The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus.However,these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system.It is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions,including feeding,energy homeostasis,the sleep/wake cycle,reward,addiction,and neuroendocrine,as well as motor control.Moreover,the absence of orexin results in narcolepsy-cataplexy,a simultaneous somatic and non-somatic dysfunction.In this review,we summarize these central functions of the orexinergic system and associated diseases,and suggest that this system may hold a key position in somatic-non-somatic integration.

  18. 75 FR 14436 - Ameren Corporation, Illinois Power Company, Central Illinois Light Company, Central Illinois...

    Science.gov (United States)

    2010-03-25

    ... Energy Regulatory Commission Ameren Corporation, Illinois Power Company, Central Illinois Light Company, Central Illinois Public Service Company, Ameren Energy Resources Company, LLC, AmerenEnergy Resources Generating Company; Notice of Filing March 18, 2010. Take notice that on March 15, 2010, Ameren...

  19. The primary Maxillary Central Incisor in the Solitary Median Maxillary Central Incisor syndrome

    DEFF Research Database (Denmark)

    Kjaer, I; Balslev-Olesen, M

    2012-01-01

    Solitary Median Maxillary Central Incisor (SMMCI) is a developmental anomaly in the permanent dentition with one single central incisor in the maxilla, positioned exactly in the midline. This condition has been associated with extra- and intraoral malformations in the frontonasal segment of the c...

  20. Actual versus perceived central bank transparency: the case of the European Central Bank

    NARCIS (Netherlands)

    van der Cruijsen, C.; Eijffinger, S.

    2008-01-01

    Central banks have become more and more transparent about their monetary policy making process. In the central bank transparency literature the distinction between actual and perceived transparency is often lacking. However, as perceptions are crucial for the actions of economic agents this distinct

  1. What Can We Learn from 15,000 Teachers in Central Europe and Central Asia?

    Science.gov (United States)

    Temple, Charles

    2000-01-01

    Describes the "Reading and Writing for Critical Thinking Project" which has now sent more than 70 volunteer teacher educators into 20 countries across Central Europe and Central Asia to help teachers to try out methods that foster active learning and critical thinking. Discusses support for the project, teaching strategies introduced,…

  2. Central Bank Independence, Centralization of Wage Bargaining, Inflation and Unemployment - Theory and Some Evidence

    NARCIS (Netherlands)

    Cukierman, A.; Lippi, F.

    1998-01-01

    This paper proposes a conceptual framework to investigate the effects of central bank independence, of the degree of centralization of wage bargaining and of the interaction between those institutional variables, on real wages, unemployment and inflation, in a framework in which unions are averse to

  3. A History of the Central Limit Theorem

    CERN Document Server

    Fischer, Hans

    2011-01-01

    This study discusses the history of the central limit theorem and related probabilistic limit theorems from about 1810 through 1950. In this context the book also describes the historical development of analytical probability theory and its tools, such as characteristic functions or moments. The central limit theorem was originally deduced by Laplace as a statement about approximations for the distributions of sums of independent random variables within the framework of classical probability, which focused upon specific problems and applications. Making this theorem an autonomous mathematical

  4. Central nervous system involvement in diabetic neuropathy.

    Science.gov (United States)

    Selvarajah, Dinesh; Wilkinson, Iain D; Davies, Jennifer; Gandhi, Rajiv; Tesfaye, Solomon

    2011-08-01

    Diabetic neuropathy is a chronic and often disabling condition that affects a significant number of individuals with diabetes. Long considered a disease of the peripheral nervous system, there is now increasing evidence of central nervous system involvement. Recent advances in neuroimaging methods detailed in this review have led to a better understanding and refinement of how diabetic neuropathy affects the central nervous system. Recognition that diabetic neuropathy is, in part, a disease that affects the whole nervous system is resulting in a critical rethinking of this disorder, opening a new direction for further research.

  5. Simulating central forces in the classroom

    CERN Document Server

    Aguirregabiria, Juan M

    2015-01-01

    We describe the easy to customize and extend open source Java program Central force workbench that can be used in the classroom to simulate the motion of a particle (or a two-body system) under central forces. It may be useful to illustrate problems in which the analytical solution is not available as well as to help students to grasp a more intuitive understanding of the main features of this kind of problem and to realize the exceptional nature of the particular case of Newtonian (and harmonic) forces. We also include some suggestions on how to use the program as a pedagogical tool.

  6. Peripheral and central mechanisms of stress resilience

    Directory of Open Access Journals (Sweden)

    Madeline L. Pfau

    2015-01-01

    Full Text Available Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress.

  7. Betweenness Centrality : Algorithms and Lower Bounds

    CERN Document Server

    Kintali, Shiva

    2008-01-01

    One of the most fundamental problems in large scale network analysis is to determine the importance of a particular node in a network. Betweenness centrality is the most widely used metric to measure the importance of a node in a network. In this paper, we present a randomized parallel algorithm, lower bounds and an algebraic method for computing betweenness centrality of all nodes in a network. We prove that any path comparison based algorithm cannot compute betweenness of all nodes in less than O(nm) time.

  8. Central odontogenic fibroma: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Nah, Kyung Soo [School of Dentistry, Busan National University, Busan (Korea, Republic of)

    2011-06-15

    Central odontogenic fibroma is a rare odontogenic neoplasm that originates from odontogenic ectomesenchyme. Here, a case of central odontogenic fibroma in a 17-year-old male is reported. Since the present case showed a multilocular radiolucency with partially ill-defined border between the right mandibular condyle and the distal root of the right mandibular third molar, differential diagnosis involved a wide range of pathosis from benign lesions like ameoloblastic fibroma and odontogenic myxoma to more aggressive lesions such as desmoplastic fibroma, juvenile aggressive fibromatosis, or fibrosarcoma.

  9. Incoerenza temporale e indipendenza della banca centrale

    Directory of Open Access Journals (Sweden)

    Bruno Jossa

    2012-04-01

    Full Text Available According to the author, the emphasis authors currently tend to place on the 'surprise effect' in order to argue for the independence of central banks is to a large extent unjustified. The main arguments for the independence of a cen-tral bank are others: firstly, the opinion that governments are induced to in-cur excessive expenditure due to reasons highlighted by public choice theo-rists and, secondly, the idea that inflation arises in connection with social conflict. Additionally, this study makes it clear that 'time inconsistency' theory is far from being a new way of stating old ideas.  JEL Codes: E58Keywords:

  10. [Centralization in obstetrics: pros and cons].

    Science.gov (United States)

    Roemer, V M; Ramb, S

    1996-01-01

    Possible advantages and disadvantages of a general centralization of German obstetric facilities are analysed in the study. The need for centralization of risk cases, especially premature births (regionalization) is pointed out. Centralization appears appropriate, since every fifth maternity unit in Germany (19.78%) has 300 or fewer deliveries per year. This one fifth of perinatal clinics accounts for 6.3% of all deliveries (N = 49450). There are appreciable differences between the old and new federal states (Bundesländer): in the recently acceded federal states, 48.7% of all perinatal clinics have deliveries of 300 and less per year. This group of perinatal clinics accounts for 29% of all deliveries in the new federal states. We have carried out a survey of the mother's attitude to centralization: out of 416 patients in the Detmold women's hospital whose mean age was 29.0 +/- 4.2 years, 90.4% were not in favor of general centralization of obstetrics. 43% were also against a centralization of risk cases (regionalization). 75% of the women surveyed objected to centralized obstetrics because of the 'possible absence of the family', the 'possible absence of students and trainees' (44.9%), the 'unfamiliarity with staff and premises' (41.8%) and 'fear of anonymity' (44.5%). The majority of all women (84.1%) did not want to have a drive more than 20 km to an obstetrics center. Fear of 'delivery in a taxi'(78.6%), the 'fear that the husband will come too late to the delivery' (65.4%) and that the 'overall course of the delivery might not be adequate for reasons of time'. The presence of a pediatrics department in conjunction with the perinatal clinic was rated very positively (93%). It is concluded from the data and further juridical considerations that centralization of risk cases (regionalization) is indispensable in the near future and that somewhat more further into the future decentralization should be carried out by closing obstetrics departments with substantially

  11. The Boolean algebra and central Galois algebras

    Directory of Open Access Journals (Sweden)

    George Szeto

    2001-01-01

    Full Text Available Let B be a Galois algebra with Galois group G, Jg={b∈B∣bx=g(xb   for all   x∈B} for g∈G, and BJg=Beg for a central idempotent eg. Then a relation is given between the set of elements in the Boolean algebra (Ba,≤ generated by {0,eg∣g∈G} and a set of subgroups of G, and a central Galois algebra Be with a Galois subgroup of G is characterized for an e∈Ba.

  12. MRI of central nervous system anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Izawa, M.; Oikawa, A.; Matoba, A.

    1987-05-01

    MRI was very useful in the evaluation of congenital anomalies of central nervous system as well as other nervous system disease with three-dimensional spatial resolution. We had experienced MRI of central nervous system anomalies, demonstrated characterisitic findings in each anomaly. MRI is useful to observe the coronal, horizontal and sagittal images of the brain and spinal cord in order to discuss the etiological mechanisms of spinal dysraphysm and its associated anomalies. In case of spina bifida cystica MRI was available to decide operative indication for radical operation and tetherd cord developed from postoperative scar or accompanied intraspinal lesions.

  13. China-Central Asia Friendship Association Founded

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>The China-Central Asia Friendship Association(CCAFA) held its inaugural meeting in Beijing on December 18,2007. The CCAFA,founded at the initiation of the CPAFFC,is a national non-profit social organization with legal person status.It aims to further expand people-to-people contact between China and the five Central Asian countries,namely Kazakhstan,Kirghizstan,Tajikistan,Turkmenistan and Uzbekistan,enhance regional cooperation and deepen good-neighbourly relations so as to consolidate the social foundation for lasting friendship between China and these countries and promote common development.

  14. L'épistémologie et l'histoire des sciences et des techniques peuvent elles aider les futurs enseignants de sciences physiques dans l'exercice de leur métier ? Regards portés pour une ingénierie de formation

    Directory of Open Access Journals (Sweden)

    Guedj Muriel

    2014-01-01

    Full Text Available Cette étude interroge la place de l'Epistémologie, l'Histoire des Sciences et des Techniques comme élément pertinent pour améliorer la professionnalité des enseignants de sciences physiques. La réflexion se nourrit des nouvelles orientations prises au sein d'écoles d'ingénieurs et de facultés de médecine qui ont fait le choix d'introduire des unités d'enseignement dédiées aux Sciences Humaines et Sociales afin de perfectionner la qualité professionnelle de leurs formations. Une étude de cas dédiée à l'enseignement de l'énergie illustre le propos.

  15. Projet pour la création d'un système d'archivage, de gestion et de mise en valeur des travaux de diplôme de la filière Architecture du paysage de l'Ecole d'ingénieurs de Lullier

    OpenAIRE

    Détraz, Patricia; Favez, Marianne; Sciboz, Joëlle; Ducharme, Daniel; Hugo, Maria

    2010-01-01

    Ce mémoire présente le travail que nous avons effectué afin de mener à bien le mandat qui nous était proposé et qui s’intitulait : Projet pour la création d’un système de gestion et d’archivage des travaux de diplôme de la filière Architecture du paysage de la HES de Lullier. Le fonds se compose de plans d’architecture de format généralement égal ou supérieur à A0 qui ne sont pas répertoriés. Ces documents représentent une part importante du patrimoine de l’Ecole d’ingénieurs de Lullier, si b...

  16. 玷污层及不同根尖倒充填材料对根尖倒充填后微渗漏影响的体外研究%In vitro studies of smear layer and retrograde fil ing material impact on apical microleakage after down -fil ed

    Institute of Scientific and Technical Information of China (English)

    李永立; 张丽萍; 武燃; 刘鹏

    2015-01-01

    Objective:Af ect apical microleakage after fil ing material with the smear layer on the application of three root canal.Method:Select 64 single root canal teeth after root canal preparation,cold lateral condensation gut a -percha root canal fil ing,after removal of the apical root canal preparation down.Randomly divided into experimental group and control group (n =30 each).Experimental group:17%EDTA +1% chloramine -T remove the smear layer,In the control group:5ml saline.Randomly selected from two groups do SEMobservation.Each group was randomly divided into 3 groups were MTA,GIC,HG were down fil ing,taking root canal fil ing the upper section.Placing micro -leakage model.First detected in concentrations ranging from 0 days 1,2,4,7,10,15,20,30 crown direction leaked square root of glucose.Results:MTA's closure at each time point were superior GIC,HG.Dif erent back molars same treatment (re-moval or retention)under the fil ing material compared pairwise dif erences were statistical y significant P 0.05).Conclusion:MTA apical closure than GIC,HG,application MTA,GIC as a retrograde fil ing material after removal of the smear lay-er apical sealing bet er,but no dif erence in HG.%目的:探讨对应用3种根管倒充填材料玷污层去留对根尖微渗漏的影响,以期为临床应用提供依据。方法:选取64颗单根管牙,常规根管预备后,冷牙胶侧向加压充填根管,根尖切除后进行根管倒预备,将其随机分为实验组与对照组(每组各32颗)。实验组:17%EDTA +2%氯亚明去除玷污层,对照组:用5mL 生理盐水冲洗。从2组中随机抽取 2颗牙做扫面电镜检测。各组分别用 MTA、GIC 和 HG 进行倒充填。去除根管上段充填物,将离体牙置于微渗漏模型,于第1、2、4、7、10、15、20和30天检测从冠方向根方漏出的葡萄糖的浓度。结果:MTA 的封闭性在各个时间点均优于 GIC、HG。离体牙同一种处理方法(去除或保留

  17. Ichthyofauna of the reservoirs of Central Vietnam

    Directory of Open Access Journals (Sweden)

    I. A. Stolbunov

    2012-01-01

    Full Text Available Species composition, distribution and abundance of fish in the pelagic and littoral zone of four reservoirs of Central Vietnam (Suoi Chau, Kam Lam, Da Ban and Suoi Dau were studied first. According to the research data the fish community of the reservoirs is represented by 43 species of 19 fish families.

  18. Central Asia: A New Great Game?

    Science.gov (United States)

    2007-11-02

    southward from civil war, or of revolutionary slogans hitting a chord with Iran’s own ethnic minorities, can only be met by economic investment and reliance...concern, both public and private, over the impact of radiation drifting into Kazakhstan has also been quite vocal .108 Chinese concerns about Central

  19. Quantum Central Processing Unit and Quantum Algorithm

    Institute of Scientific and Technical Information of China (English)

    王安民

    2002-01-01

    Based on a scalable and universal quantum network, quantum central processing unit, proposed in our previous paper [Chin. Phys. Left. 18 (2001)166], the whole quantum network for the known quantum algorithms,including quantum Fourier transformation, Shor's algorithm and Grover's algorithm, is obtained in a unitied way.

  20. Intracranial calcification in central diabetes insipidus.

    Science.gov (United States)

    Al-Kandari, Salwa Ramadan; Pandey, Tarun; Badawi, Mona H

    2008-01-01

    Intracranial calcification is a known but extremely rare complication of diabetes insipidus. To date, only 16 patients have been reported and all had the peripheral (nephrogenic) type of diabetes insipidus. We report a child with intracranial calcification complicating central diabetes insipidus. We also report a child with nephrogenic diabetes insipidus, and compare the patterns of intracranial calcification.

  1. Intracranial calcification in central diabetes insipidus

    Energy Technology Data Exchange (ETDEWEB)

    Al-Kandari, Salwa R. [Al Razi Hospital, Department of Clinical Radiology, Kuwait (Kuwait); Pandey, Tarun [Al Razi Hospital, Department of Clinical Radiology, Kuwait (Kuwait); University of Arkansas for Medical Sciences, Radiology Department, Little Rock, AR (United States); Badawi, Mona H. [Al-Adan Hospital, Department of Paediatrics, Kuwait (Kuwait)

    2008-01-15

    Intracranial calcification is a known but extremely rare complication of diabetes insipidus. To date, only 16 patients have been reported and all had the peripheral (nephrogenic) type of diabetes insipidus. We report a child with intracranial calcification complicating central diabetes insipidus. We also report a child with nephrogenic diabetes insipidus, and compare the patterns of intracranial calcification. (orig.)

  2. Workers' Central Life Interests and Job Performance.

    Science.gov (United States)

    Dubin, Robert; Champoux, Joseph E.

    Supervisors' ratings of individual industrial workers appear to be related to the central life interests (CLI) of the workers. The group of workers who had a job-oriented CLI received the highest ratings from their superivsors among the three CLI groups on Initiative and Application, Cooperation and Quantity of Work and were rated low on…

  3. Dust on UA1 central detector

    CERN Multimedia

    1982-01-01

    In March 1982 the central derector of UA1 was contaminated by dirt in the compressed air used for cooling during the bakeout of the beam pipe. The lengthy cleaning imposed a change of the collider schedule (Annual Report 1982 p. 114).

  4. Central serotonin metabolism and frequency of depression

    NARCIS (Netherlands)

    Praag, H.M. van; Haan, S. de

    1979-01-01

    Central serotonin (5-hydroxytryptamine; 5-HT) metabolism can be disturbed in a subgroup of patients with vital (endogenous, primary) depression. Presumably these disturbances do not result from the depression and have a predisposing rather than a causative relationship to it. This latter statement i

  5. Betweenness centrality patterns in random planar graphs

    CERN Document Server

    Lion, Benjamin

    2016-01-01

    Random planar graphs appear in a variety of context and it is important for many different applications to be able to characterize their structure. Local quantities fail to give interesting information and it seems that path-related measures are able to convey relevant information about the organization of these structures. In particular, nodes with a large betweenness centrality (BC) display non-trivial patterns, such as loops of very central nodes. We discuss briefly empirical results for different random planar graphs and we propose a toy model which allows us to discuss the condition for the emergence of non-trivial patterns such as central loops. This toy model is made of a star network with $N_b$ branches of size $n$ and links of weight $1$, superimposed to a loop at distance $\\ell$ from the center and with links of weight $w$. We estimate for this model the BC at the center and on the loop and we show that the loop can be more central than the origin if $w

  6. Gabapentin inhibits central sensitization during migraine

    Institute of Scientific and Technical Information of China (English)

    Yanbo Zhang; Guo Shao; Wei Zhang; Sijie Li; Jingzhong Niu; Dongmei Hu; Mingfeng Yang; Xunming Ji

    2013-01-01

    Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein ki-nase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C ac-tivation.

  7. Ferrobasalts from the Central Indian Ocean Basin

    Digital Repository Service at National Institute of Oceanography (India)

    Iyer, S.D.; Mukhopadhyay, R.; Popko, D.C.

    The occurrence of ferrobasalts recovered from the Central Indian Ocean Basin crust generated at the Southeast Indian Ridge during a phase of moderate to fast spreading accretion (approx 110-190 mm/yr, full rate) is reported. FeO (13-19%), and Ti...

  8. Universities and Knowledge Production in Central Europe

    Science.gov (United States)

    Kwiek, Marek

    2012-01-01

    The article discusses an East/West divide in Europe in university knowledge production. It argues that the communist and post-communist legacies in the four major Central European economies studied (Poland, Hungary, the Czech Republic and the Slovak Republic) matter substantially for educational and research systems. The differences in university…

  9. The central limit theorem and chaos

    Institute of Scientific and Technical Information of China (English)

    NIU Ying-xuan

    2009-01-01

    Let X be a compact metric space and f : X → X be a continuous map. This paper studies some relationships between stochastic and topological properties of dynamical systems.It is shown that if f satisfies the central limit theorem, then f is topologically ergodic and f is sensitively dependent on initial conditions if and only if f is neither minimal nor equicontinuous.

  10. Award Winning Communication Programs: Centrality or Confusion?

    Science.gov (United States)

    Beadle, Mary E.; Schmidt, Jacqueline J.

    1999-01-01

    Presents a post hoc analysis of peer-identified excellent departments at small colleges (5,000 or fewer undergraduates) to discover if they suffer from a lack of centrality. Hopes that this information may be used to help departments plan curriculum, develop evaluation methods, or write mission statements to strengthen existing programs or defend…

  11. Central Pontine and Extrapontine Myelinolysis in Encephalitis

    Directory of Open Access Journals (Sweden)

    Suvrendu Sankar Kar

    2013-08-01

    Full Text Available A 15 years male presented with fever, convulsion, unconsciousness and dystonia of acute onset. He was investigated and treated. MRI brain shows central pontine and extrapontine myelinolysis. Osmotic injury, Wilson's disease and other possibilities were excluded by clinical findings with supportive investigations. Patient was improved satisfactorily with treatment. [Natl J Med Res 2013; 3(4.000: 420-421

  12. Central African Security: Conflict in the Congo

    Science.gov (United States)

    2002-01-01

    Alliances mouvantes et conflits extraterritoriaux en Afrique Centrale. Paris: L’Hamarttan. Jean-Claude Willame, Banyarwanda et Banyamulenge: Violence...ethnique et gestion de l’identitaire au Kivu. Paris; L’Harmattan, 1997. Crawford Young, “Zaire: The Anatomy of a Failed State,” in David Birmingham & Phyllis

  13. Performance Management in Dutch Central Government

    NARCIS (Netherlands)

    Mol, Nico P.; Kruijf, de Johan A.M.

    2004-01-01

    This article investigates how and to what extent performance indicators in Dutch central government are actually embedded in performance management. In a case study encompassing 12 government organizations, the relevance of the indicators presented is analysed in three stages: (1) with respect to th

  14. Imaging of the fetal central nervous system

    NARCIS (Netherlands)

    Pistorius, L.R.

    2008-01-01

    Introduction : Ultrasound and MR imaging of the fetal central nervous system (CNS) develop at an ever-increasing rate. Theoretically, the two modalities should be synergistic, but a literature review revealed the difficulties of determining the merit of either technique and revealed gaps in our know

  15. Superficial siderosis in the central nervous system

    Energy Technology Data Exchange (ETDEWEB)

    Pythinen, J. [Oulu Univ. (Finland). Dept. of Diagnostic Radiology; Paeaekkoe, E. [Oulu Univ. (Finland). Dept. of Diagnostic Radiology; Ilkko, E. [Oulu Univ. (Finland). Dept. of Diagnostic Radiology

    1995-02-01

    We describe a rare entity, superficial siderosis of the central nervous system, due to multiple small episodes of subarachnoid haemorrhage from any source. Non-specific neurological findings are associated with deposition of iron-containing pigments in the leptomeninges and superficial layers of the cortex. T2-weighted magnetic resonance imaging demonstrates characteristic low signal in the meninges. (orig.)

  16. Ablated tektite from the central Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Glass, B.P.; Chapman, D.R.; ShyamPrasad, M.

    , if it originated in Southeast Asia, it must have had a very shallow trajectory (only a few degrees) and a velocity on the order of 7 km/s as it re-entered the atmosphere. The central Indian Ocean tektite is compositionally similar to high-magnesium (HMg...

  17. The ultimate determinants of central bank independence

    NARCIS (Netherlands)

    Eijffinger, S.C.W.; Schaling, E.

    1995-01-01

    Using a graphical method, a new way of determining the optimal degree of central bank conservativeness is developed in this paper. Unlike Lohmann (1992) and Rogoff (1985), we are able to express the upper and lower bounds of the interval containing the optimal degree of conservativeness in terms of

  18. Stochastic modelling of central heating systems

    DEFF Research Database (Denmark)

    Hansen, Lars Henrik

    1997-01-01

    and the degree Erhvervsforsker (a special Danish degree, equivalent to ``Industrial Ph.D.''). The thesis is mainly concerned with experimental design and system identification for individual components in water based central heating systems. The main contribution to this field is on the nonlinear dynamic...

  19. The Marstal Central Solar Heating Plant

    DEFF Research Database (Denmark)

    Heller, Alfred; Jochen, Dahm

    1999-01-01

    The central solar heating plant in Marstal is running since 1996 and has been monitored since. The resulting data from the plant is analysed and the plant performance evaluated. A TRNSYS-model (computersimulation) id prepared and validated based on the measured data from the plant. Acceptable good...

  20. Central Computer IMS Processing System (CIMS).

    Science.gov (United States)

    Wolfe, Howard

    As part of the IMS Version 3 tryout in 1971-72, software was developed to enable data submitted by IMS users to be transmitted to the central computer, which acted on the data to create IMS reports and to update the Pupil Data Base with criterion exercise and class roster information. The program logic is described, and the subroutines and…