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Sample records for central control system

  1. Central control system for the EAST tokamak

    International Nuclear Information System (INIS)

    Sun Xiaoyang; Ji Zhenshan; Wu Yicun; Luo Jiarong

    2008-01-01

    The architecture, the main function and the design scheme of the central control system and the collaboration system of EAST tokamak are described. The main functions of the central control system are to supply a union control interface for all the control, diagnoses, and data acquisition (DAQ) subsystem and it is also designed to synchronize all those subsystem. (authors)

  2. Conceptual design of centralized control system for LHD

    International Nuclear Information System (INIS)

    Kaneko, H.; Yamazaki, K.; Taniguchi, Y.

    1992-01-01

    A centralized control system for a fusion experimental machine is discussed. A configuration whereby a number of complete and uniform local systems are controlled by a central computer, a timer and an interlock system is appropriate for the control system of the Large Helical Device (LHD). A connection among local systems can be made by Ethernet, because a faster transmission of control data is processed by a specific system. (author)

  3. Centralization and Decentralization in the TRIUMF control system

    International Nuclear Information System (INIS)

    Dohan, D.A.; Gurd, D.P.

    1984-01-01

    Distributed control is characterized by a number of different concepts relating to hardware, software, data bases, and control stations. Although some control system designs are more centralized than others, all contain elements of both approaches. In particular, the TRIUMF system contains a unique blend of centralized and distributed attributes, deriving primarily from the multi-sourced CAMAC and memory systems at its executive node. The increased demands of an expanding accelerator laboratory have made it timely to consider strategies for expansion of the TRIUMF Control System. These requirements have led to reflections on one of the major themes of this conference - centralized vs distributed digital control systems for accelerators. This paper discusses the way in which the TRIUMF system successfully combines elements of both approaches

  4. The NSTX Central Instrumentation and Control System

    International Nuclear Information System (INIS)

    G. Oliaro; J. Dong; K. Tindall; P. Sichta

    1999-01-01

    Earlier this year the National Spherical Torus Experiment (NSTX) at the Princeton Plasma Physics Laboratory achieved ''first plasma''. The Central Instrumentation and Control System was used to support plasma operations. Major elements of the system include the Process Control System, Plasma Control System, Network System, Data Acquisition System, and Synchronization System. This paper will focus on the Process Control System. Topics include the architecture, hardware interface, operator interface, data management, and system performance

  5. Concept design for the central control system of HL-2A

    International Nuclear Information System (INIS)

    Song Xianming; Li Qiang; Jiang Chao

    2001-01-01

    The design principle and basic structure of the central control system for HL-2A Tokamak are introduced. Having been limited by manpower and money, the central control system should not be too expensive and too advanced. On the other hand, because of the complexity of the machine and the difficulty the author will encounter when operating the machine, the central control system should be advanced enough. If use the same technology for HL-1M to control HL-2A, the author would fail to fulfill authors' experiment goal. The central control system consists of software and hardware. The software mainly includes: (a) system monitor and control software; (b) discharge monitor and control software; (c) network and communication software. Hardware includes: (a) PLC for machine control, personnel protection and machine protection; and (b) VME computer, for the feedback control of the discharge

  6. MINED GEOLOGIC DISPOSAL SYSTEM (MGDS) MONITORING AND CONTROL SYSTEMS CENTRALIZATION TECHNICAL REPORT

    International Nuclear Information System (INIS)

    M.J. McGrath

    1998-01-01

    The objective of this report is to identify and document Mined Geologic Disposal System (MGDS) requirements for centralized command and control. Additionally, to further develop the MGDS monitoring and control functions. This monitoring and control report provides the following information: (1) Determines the applicable requirements for a monitoring and control system for repository operations and construction (excluding Performance Confirmation). (2) Makes a determination as to whether or not centralized command and control is required

  7. Conceptual design for the NSTX Central Instrumentation and Control System

    International Nuclear Information System (INIS)

    Bashore, D.; Oliaro, G.; Roney, P.; Sichta, P.; Tindall, K.

    1997-01-01

    The design and construction phase for the National Spherical Torus Experiment (NSTX) is under way at the Princeton Plasma Physics Laboratory (PPPL). Operation is scheduled to begin on April 30, 1999. This paper describes the conceptual design for the NSTX Central Instrumentation and Control (I and C) System. Major elements of the Central I and C System include the Process Control System, Plasma Control System, Network System, Data Acquisition System, and Synchronization System to support the NSTX experimental device

  8. A comprehensive centralized control system for radiation waste treatment facility

    International Nuclear Information System (INIS)

    Kong Jinsong

    2014-01-01

    A comprehensive centralized control system is designed for the radiation waste treatment facility that lacking of coordinated operational mechanism for the radiation waste treatment. The centralized control and alarm linkage of various systems is implemented to ensure effectively the safety of nuclear facility and materials, improve the integral control ability through advanced informatization ways. (author)

  9. Centralization and decentralization in the TRIUMF control system

    International Nuclear Information System (INIS)

    Dohan, D.A.; Gurd, D.P.

    1983-09-01

    The increased demands of an expanding accelerator laboratory have made it timely to consider strategies for expansion of the TRIUMF Control System. These requirements have led to reflections on one of the major themes of this conference - centralized vs. distributed digital control systems for accelerators. This paper discusses the way in which the TRIUMF system successfully combines elements of both approaches

  10. X window terminals in TRIUMF's central control system

    International Nuclear Information System (INIS)

    Kadantsev, S.G.; Kadantseva, T.P.; Davison, B.; Diel, D.A.; Grant, P.A.; Klassen, E.; Lee, K.S.; Mouat, M.M.; Richards, J.E.; Yogendran, P.J.

    1994-08-01

    TRIUMF's Central Control System is being upgraded. In this process, an environment that suits the needs of cyclotron operational use and the Controls Group's development and maintenance duties has been sought. Over the years since TRIUMF's inception, workstations and a variety of dedicated input/output devices have been introduced into the main console of the Control Room and into the offices of the Controls Group personnel. A number of factors including the overhead of system management, price/performance, time to obsolescence, flexibility, and reliability have affected the suitability of workstations and the other I/O devices. In the new configuration, a generic display device plays a very important role in the Central Control System. X terminals have proven to be superior to workstations and other display devices and are now the display medium of choice in TRIUMF's Controls Group. This paper reviews the TRIUMF Controls Group's experiences with X terminals. A number of aspects of X terminal use in a particle accelerator environment are discussed. Topics include functionality, hardware configuration, software management, relative cost, performance, reliability, boot mechanisms, application suitability, and operator acceptance. (author). 8 refs., 3 figs

  11. Design of central control system for large helical device (LHD)

    International Nuclear Information System (INIS)

    Yamazaki, K.; Kaneko, H.; Yamaguchi, S.; Watanabe, K.Y.; Taniguchi, Y.; Motojima, O.

    1993-11-01

    The world largest superconducting fusion machine LHD (Large Helical Device) is under construction in Japan, aiming at steady state operations. Its basic control system consists of UNIX computers, FDDI/Ethernet LANs, VME multiprocessors and VxWorks real-time OS. For flexible and reliable operations of the LHD machine a cooperative distributed system with more than 30 experimental equipments is controlled by the central computer and the main timing system, and is supervised by the main protective interlock system. Intelligent control systems, such as applications of fuzzy logic and neural networks, are planed to be adopted for flexible feedback controls of plasma configurations besides the classical PID control scheme. Design studies of its control system and related R and D programs with coil-plasma simulation systems are now being performed. The construction of the LHD Control Building in a new site will begin in 1995 after finishing the construction of the LHD Experimental Building, and the hardware construction of the LHD central control equipments will be started in 1996. A first plasma production by means of this control system is expected in 1997. (author)

  12. Central and peripheral nervous systems: master controllers in cancer metastasis.

    Science.gov (United States)

    Shi, Ming; Liu, Dan; Yang, Zhengyan; Guo, Ning

    2013-12-01

    Central and sympathetic nervous systems govern functional activities of many organs. Solid tumors like organs are also innervated by sympathetic nerve fibers. Neurotransmitters released from sympathetic nerve fibers can modulate biological behaviors of tumor cells. Multiple physiologic processes of tumor development may be dominated by central and sympathetic nervous systems as well. Recent studies suggest that dysfunction of central and sympathetic nervous systems and disorder of the hormone network induced by psychological stress may influence malignant progression of cancer by inhibiting the functions of immune system, regulating metabolic reprogramming of tumor cells, and inducing interactions between tumor and stromal cells. Over-release of inflammatory cytokines by tumors may aggravate emotional disorder, triggering the vicious cycles in tumor microenvironment and host macroenvironment. It is reasonable to hypothesize that cancer progression may be controlled by central and sympathetic nervous systems. In this review, we will focus on the recent information about the impacts of central and sympathetic nervous systems on tumor invasion and metastasis.

  13. How to design electrical systems with central control capability for industrial plants

    Energy Technology Data Exchange (ETDEWEB)

    Cigolini, S.; Galati, G.; Lionetto, P.F.; Stiz, M. (Siemens, Milan (Italy) Centro Elettrotecnico Sperimentale Italiano, Milan (Italy))

    1991-12-01

    The modern centralized control system, incorporating microprocessors, constitutes an extremely efficacious instrument for the management of an industrial plant's electrical system and provides the performance, reliability, flexibility and safety features required by today's technologically advanced plant processes. The use of intelligent centralized control systems, capable of autonomous operation and dialoguing with industrial plant electrical systems, simplifies the design of the overall plant. This paper reviews the main design criteria for the automated systems and gives examples of some suitable commercially available intelligent systems.

  14. Centralized multiprocessor control system for the frascati storage rings DAΦNE

    International Nuclear Information System (INIS)

    Di Pirro, G.; Milardi, C.; Serio, M.

    1992-01-01

    We describe the status of the DANTE (DAΦne New Tools Environment) control system for the new DAΦNE Φ-factory under construction at the Frascati National Laboratories. The system is based on a centralized communication architecture for simplicity and reliability. A central processor unit coordinates all communications between the consoles and the lower level distributed processing power, and continuously updates a central memory that contains the whole machine status. We have developed a system of VME Fiber Optic interfaces allowing very fast point to point communication between distant processors. Macintosh II personal computers are used as consoles. The lower levels are all built using the VME standard. (author)

  15. Update on the TRIUMF Central Control System

    International Nuclear Information System (INIS)

    Mouat, M.M.; Diel, D.A.; Grant, P.A.; Klassen, E.; Lee, K.S.; Ludgate, G.A.; Richards, J.E.; Yogendran, P.J.; Kadantsev, S.G.

    1994-01-01

    The continuing evolution of the TRIUMF Central Control System is currently subject to three major influences. Most imperative is the need to replace the obsolete Nova computers that still handle much of the routine cyclotron operation. Smooth integration of a number of isolated control systems into the CCS is another focus. The third major force arises from the requirements of developing new projects in a system that has reached serious expansion constraints. The plan for phasing out the Novas, integrating the orphaned systems and allowing expansion of the CCS in a smooth fashion is discussed. This is a conservative approach, relying on the strengths of the present hardware configuration, the substantial financial investment in existing equipment, and the expertise of available personnel, while meeting the present and future requirements. Details of the modified and expanded hardware configuration are described. This review also briefly mentions new support for device access, X-window displays, database usage, and plans for one of the upcoming projects, namely an eye cancer proton therapy treatment facility. ((orig.))

  16. Centralized digital control of accelerators

    International Nuclear Information System (INIS)

    Melen, R.E.

    1983-09-01

    In contrasting the title of this paper with a second paper to be presented at this conference entitled Distributed Digital Control of Accelerators, a potential reader might be led to believe that this paper will focus on systems whose computing intelligence is centered in one or more computers in a centralized location. Instead, this paper will describe the architectural evolution of SLAC's computer based accelerator control systems with respect to the distribution of their intelligence. However, the use of the word centralized in the title is appropriate because these systems are based on the use of centralized large and computationally powerful processors that are typically supported by networks of smaller distributed processors

  17. Smart electromechanical systems the central nervous system

    CERN Document Server

    Kurbanov, Vugar

    2017-01-01

    This book describes approaches to solving the problems of developing the central nervous system of robots (CNSR) based on smart electromechanical systems (SEMS) modules, principles of construction of the various modules of the central nervous system and variants of mathematical software CNSR in control systems for intelligent robots. It presents the latest advances in theory and practice at the Russian Academy of Sciences. Developers of intelligent robots to solve modern problems in robotics are increasingly addressing the use of the bionic approach to create robots that mimic the complexity and adaptability of biological systems. These have smart electromechanical system (SEMS), which are used in various cyber-physical systems (CPhS), and allow the functions of calculation, control, communications, information storage, monitoring, measurement and control of parameters and environmental parameters to be integrated. The behavior of such systems is based on the information received from the central nervous syst...

  18. Central control of body temperature.

    Science.gov (United States)

    Morrison, Shaun F

    2016-01-01

    Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis.

  19. Overview of data acquisition and central control system of steady state superconducting Tokamak (SST-1)

    Energy Technology Data Exchange (ETDEWEB)

    Pradhan, S., E-mail: pradhan@ipr.res.in; Mahajan, K.; Gulati, H.K.; Sharma, M.; Kumar, A.; Patel, K.; Masand, H.; Mansuri, I.; Dhongde, J.; Bhandarkar, M.; Chudasama, H.

    2016-11-15

    Highlights: • The paper gives overview on SST-1 data acquisition and central control system and future upgrade plans. • The lossless PXI based data acquisition of SST-1 is capable of acquiring around 130 channels with sampling frequency ranging from 10 KHz to 1 MHz sampling frequency. • Design, architecture and technologies used for central control system (CCS) of SST-1. • Functions performed by CCS. - Abstract: Steady State Superconducting Tokamak (SST-1) has been commissioned successfully and has been carrying out limiter assisted ohmic plasma experiments since the beginning of 2014 achieving a maximum plasma current of 75 kA at a central field of 1.5 T and the plasma duration ∼500 ms. In near future, SST-1 looks forward to carrying out elongated plasma experiments and stretching plasma pulses beyond 1 s. The data acquisition and central control system (CCS) for SST-1 are distributed, modular, hierarchical and scalable in nature The CCS has been indigenously designed, developed, implemented, tested and validated for the operation of SST-1. The CCS has been built using well proven technologies like Redhat Linux, vxWorks RTOS for deterministic control, FPGA based hardware implementation, Ethernet, fiber optics backbone for network, DSP for real-time computation & Reflective memory for high-speed data transfer etc. CCS in SST-1 controls & monitors various heterogeneous SST-1 subsystems dispersed in the same campus. The CCS consists of machine control system, basic plasma control system, GPS time synchronization system, storage area network (SAN) for centralize data storage, SST-1 networking system, real-time networks, SST-1 control room infrastructure and many other supportive systems. Machine Control System (MCS) is a multithreaded event driven system running on Linux based servers, where each thread of the software communicates to a unique subsystem for monitoring and control from SST-1 central control room through network programming. The CCS hardware

  20. Overview of data acquisition and central control system of steady state superconducting Tokamak (SST-1)

    International Nuclear Information System (INIS)

    Pradhan, S.; Mahajan, K.; Gulati, H.K.; Sharma, M.; Kumar, A.; Patel, K.; Masand, H.; Mansuri, I.; Dhongde, J.; Bhandarkar, M.; Chudasama, H.

    2016-01-01

    Highlights: • The paper gives overview on SST-1 data acquisition and central control system and future upgrade plans. • The lossless PXI based data acquisition of SST-1 is capable of acquiring around 130 channels with sampling frequency ranging from 10 KHz to 1 MHz sampling frequency. • Design, architecture and technologies used for central control system (CCS) of SST-1. • Functions performed by CCS. - Abstract: Steady State Superconducting Tokamak (SST-1) has been commissioned successfully and has been carrying out limiter assisted ohmic plasma experiments since the beginning of 2014 achieving a maximum plasma current of 75 kA at a central field of 1.5 T and the plasma duration ∼500 ms. In near future, SST-1 looks forward to carrying out elongated plasma experiments and stretching plasma pulses beyond 1 s. The data acquisition and central control system (CCS) for SST-1 are distributed, modular, hierarchical and scalable in nature The CCS has been indigenously designed, developed, implemented, tested and validated for the operation of SST-1. The CCS has been built using well proven technologies like Redhat Linux, vxWorks RTOS for deterministic control, FPGA based hardware implementation, Ethernet, fiber optics backbone for network, DSP for real-time computation & Reflective memory for high-speed data transfer etc. CCS in SST-1 controls & monitors various heterogeneous SST-1 subsystems dispersed in the same campus. The CCS consists of machine control system, basic plasma control system, GPS time synchronization system, storage area network (SAN) for centralize data storage, SST-1 networking system, real-time networks, SST-1 control room infrastructure and many other supportive systems. Machine Control System (MCS) is a multithreaded event driven system running on Linux based servers, where each thread of the software communicates to a unique subsystem for monitoring and control from SST-1 central control room through network programming. The CCS hardware

  1. The MSG Central Facility - A Mission Control System for Windows NT

    Science.gov (United States)

    Thompson, R.

    The MSG Central Facility, being developed by Science Systems for EUMETSAT1, represents the first of a new generation of satellite mission control systems, based on the Windows NT operating system. The system makes use of a range of new technologies to provide an integrated environment for the planning, scheduling, control and monitoring of the entire Meteosat Second Generation mission. It supports packetised TM/TC and uses Science System's Space UNiT product to provide automated operations support at both Schedule (Timeline) and Procedure levels. Flexible access to historical data is provided through an operations archive based on ORACLE Enterprise Server, hosted on a large RAID array and off-line tape jukebox. Event driven real-time data distribution is based on the CORBA standard. Operations preparation and configuration control tools form a fully integrated element of the system.

  2. Architecture of central control system for the 10 MW ECRH-plant at W7-X

    Energy Technology Data Exchange (ETDEWEB)

    Braune, H. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)], E-mail: harald.braune@ipp.mpg.de; Brand, P. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Erckmann, V.; Jonitz, L. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Leonhardt, W.; Mellein, D. [Forschungszentrum Karlsruhe, Association EURATOM-FZK, IHM, FZK, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Michel, G. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Mueller, G. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Purps, F. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Schlueter, K.-H. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Winkler, M. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)

    2007-10-15

    Electron Cyclotron Resonance Heating (ECRH) is the main heating method for the Wendelstein 7-X stellarator (W7-X) which is presently under construction at IPP Greifswald. The mission of W7-X is to demonstrate the inherent steady state capability of stellarators at reactor relevant plasma parameters. A modular 10 MW ECRH-plant at 140 GHz with 1 MW CW-capability power for each module is also under construction to support the scientific objectives. The commissioning of the ECRH-plant is well under way; three gyrotrons are operational. The strict modular design allows to operate each gyrotron separately and independent from all others. The ECRH-plant consists of many devices such as gyrotrons and high voltage power supplies, superconductive magnets, collector sweep coils, gyrotron cooling systems with many water circuits and last but not least the quasi-optical transmission line for microwaves with remote controlled mirrors and further water cooled circuits. All these devices are essential for a CW operation. A steady state ECRH has specific requirements on the stellarator machine itself, on the microwave sources, transmission elements and in particular on the central control system. The quasi steady state operation (up to 30 min) asks for real time microwave power adjustment during the different segments of one stellarator discharge. Therefore, the ECRH-plant must operate with a maximum reliability and availability. A capable central control system is an important condition to achieve this goal. The central control system for the 10 MW ECRH-plant at W7-X comprises three main parts. In detail these are the voltage and current regulation of each gyrotron, the interlock system to prevent the gyrotrons from damages and the remote control system based on a hierarchy set of PLCs and computers. The architecture of this central control system is presented.

  3. Elimination of Oscillations in a Central Heating System using Pump Control

    DEFF Research Database (Denmark)

    Andersen, Palle; Pedersen, Tom Søndergaard; Stoustrup, Jakob

    2000-01-01

    In central heating systems with thermostatic valve temperature control it is a well known fact that room temperature oscillations may occur when the heat demand becomes low due to the non-linear behavior of the control loop. This is not only discomforting but it also increases the energy cost...... of heating the room. Using the pump speed as an active part in control is it shown that the room temperature may be stabilized in a wider interval of heat demand. The idea is to control the pump speed in a way that keeps the thermostatic valve within a suitable operating area using an estimate of the valve...... position. The position is estimated from the pump terminals, using the pump flow and the pump differential pressure. The concept is tested on a small central heating test bench. The results show that it is possible to stabilize the room temperature even at part load conditions...

  4. Central nervous system

    Science.gov (United States)

    The central nervous system is composed of the brain and spinal cord. Your brain and spinal cord serve as the main "processing center" for your entire nervous system. They control all the workings of your body.

  5. Leptin and the central nervous system control of glucose metabolism.

    Science.gov (United States)

    Morton, Gregory J; Schwartz, Michael W

    2011-04-01

    The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.

  6. Design and realization of the J-TEXT tokamak central control system

    International Nuclear Information System (INIS)

    Yang Zhoujun; Zhuang Ge; Hu Xiwei; Zhang Ming; Qiu Shengshun; Wang Zhijiang; Ding Yonghua; Pan Yuan

    2009-01-01

    The Joint Texas Experimental Tokamak (J-TEXT), a medium-sized conventional tokamak, serves as a user experimental facility in the China-USA fusion research community. Development of a flexible and easy-to-use J-TEXT central control system (CCS) is of supreme importance for users to coordinate the experimental scenarios with full integration into the discharge operation. This paper describes in detail the structure and functions of the J-TEXT CCS system as well as the performance in practical implementation. Results obtained from both commissioning and routine operations show that the J-TEXT CCS system can offer a satisfactory and effective control that is reliable and stable. The J-TEXT tokamak achieved high-quality performance in its first-ever experimental campaign with this CCS system.

  7. Systemic control of brown fat thermogenesis: integration of peripheral and central signals.

    Science.gov (United States)

    Schulz, Tim J; Tseng, Yu-Hua

    2013-10-01

    Brown adipose tissue (BAT) is of great scientific interest as a potential target to treat obesity. The development of novel strategies to quantify brown fat thermogenesis in adult humans now enables minimally invasive assessment of novel pharmacotherapeutics. Input from the central nervous system via sympathetic efferents is widely regarded as the key controller of BAT-mediated thermogenesis in response to changes in body temperature or nutrient availability. More recently, however, it has become clear that locally secreted signals and endocrine factors originating from multiple organs can control the recruitment of brown adipocytes and, more importantly, induce thermogenesis in brown fat. Thus, they provide an attractive strategy to fine-tune brown fat thermogenesis independent of classical temperature sensing. Here, we summarize recent findings on bone morphogenetic protein signaling as an example of secreted factors in the regulation of brown adipocyte formation and systemic control of energy metabolism. We further highlight endocrine communication routes between the different types of brown adipocytes and other organs that contribute to regulation of thermogenesis. Thus, emerging evidence suggests that the classical mechanisms of central temperature sensing and sympathetic nervous system-driven thermogenesis are complemented by local and endocrine signals to determine systemic energy homeostasis. © 2013 New York Academy of Sciences.

  8. Coordinated control of a combined cycle thermoelectric central; Control coordinado de una central termoelectrica de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Parra, Marino; Castelo Cuevas, Luis [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-03-01

    In this paper the coordinated control (CC) of the Distributed Control System (Sistema de Control Distribuido) (SICODI) of the Combined Cycle Central of Gomez Palacio, Durango, is presented. The description of the control scheme and its realization in software is made. From the scheme the operation strategies and automation, supervision and control are described in detail. The software components of the programming are described, the program structure and control data and its implementation in working stations VAX 3100 under the operating system VMS (Virtual Memory System), are described. [Espanol] En este articulo se presenta el control coordinado (CC) del Sistema de Control Distribuido (Sicodi) de la central de ciclo combinado Gomez Palacio, Durango. Se describe el esquema de control y su realizacion en software. Del esquema se detallan las estrategias de operacion y automatizacion, supervision y control. Del software se describen los componentes de la programacion, la estructura de programas y datos del control y su implementacion en estaciones de trabajo VAX 3100 bajo el sistema operativo VMS (Virtual Memory System).

  9. Central alarm system replacement in NPP Krsko

    International Nuclear Information System (INIS)

    Cicvaric, D.; Susnic, M.; Djetelic, N.

    2004-01-01

    Current NPP Krsko central alarm system consists of three main segments. Main Control Board alarm system (BETA 1000), Ventilation Control Board alarm system (BETA 1000) and Electrical Control Board alarm system (BETA 1100). All sections are equipped with specific BetaTone audible alarms and silence, acknowledge as well as test push buttons. The main reason for central alarm system replacement is system obsolescence and problems with maintenance, due to lack of spare parts. Other issue is lack of system redundancy, which could lead to loss of several Alarm Light Boxes in the event of particular power supply failure. Current central alarm system does not provide means of alarm optimization, grouping or prioritization. There are three main options for central alarm system replacement: Conventional annunciator system, hybrid annunciator system and advanced alarm system. Advanced alarm system implementation requires Main Control Board upgrade, integration of process instrumentation and plant process computer as well as long time for replacement. NPP Krsko has decided to implement hybrid alarm system with patchwork approach. The new central alarm system will be stand alone, digital, with advanced filtering and alarm grouping options. Sequence of event recorder will be linked with plant process computer and time synchronized with redundant GPS signal. Advanced functions such as link to plant procedures will be implemented with plant process computer upgrade in outage 2006. Central alarm system replacement is due in outage 2004.(author)

  10. Centralized digital control of accelerators

    International Nuclear Information System (INIS)

    Melen, R.E.

    1984-01-01

    Upon careful examination of the architecture of SLAC's computer control systems, it becomes evident that the distribution of the systems' intelligence generally falls into tree-like layers. The first layer typically consists of a central computer complex incorporating one or more relatively large and powerful processors. The more modern systems use state-of-the-art 32-bit processors with several megabytes of RAM and several hundreds of megabytes of disk memory. Further, they support extensive user-friendly operating systems and program development facilities. The second layer typically consists of several smaller processors which are downloaded from the central complex and whose primary task is to provide data acquisition and distribution. The more modern systems are 16-bit processors with several hundred kilobytes of RAM and no disk memory. The third layer typically consists of several tens or hundreds of micro-processors, each dedicated to a single device. The micro-processors for these ''dedicated intelligent controllers'' are small and inexpensive and typically require less than 32 kilobytes of RAM or EPROM memory. Their hardware may be general purpose in nature or may be built into the architecture of the device itself. Figure 5 illustrates several of the relevant features of each of these layers. This paper serves to illustrate that SLAC is commited to the centralized digital control of its accelerators

  11. BWR plant advanced central control panel PODIA

    International Nuclear Information System (INIS)

    Fujii, K.; Hayakawa, H.; Ikeda, Y.; Neda, T.; Suto, O.; Takamiya, S.

    1983-01-01

    BWR plant central control panels have become more and more enlarged and complicated recently due to the magnification of the scale of a plant and the requirement to reinforce safety. So, it is important to make communication between men and the complicated central control panel smooth. Toshiba has developed an advanced central control panel, named PODIA, which uses many computers and color CRTs, and PODIA is now in the stage of application to practical plants. In this article, the writers first touch upon control functions transition in the central control room, the PODIA position concerning the world-wide trend in this technology phase and the human engineering on the design. Then they present concrete design concepts for the control board and computer system which constitute PODIA

  12. Centralized Gap Clearance Control for Maglev Based Steel-Plate Conveyance System

    Directory of Open Access Journals (Sweden)

    GUNEY, O. F.

    2017-08-01

    Full Text Available The conveyance of steel-plates is one of the potential uses of the magnetic levitation technology in industry. However, the electromagnetic levitation systems inherently show nonlinear feature and are unstable without an active control. Well-known U-shaped or E-shaped electromagnets cannot provide redundant levitation with multiple degrees of freedom. In this paper, to achieve the full redundant levitation of the steel plate, a quadruple configuration of U shaped electromagnets has been proposed. To resolve the issue of instability and attain more robust levitation, a centralized control algorithm based on a modified PID controller (I PD is designed for each degree of freedom by using the Manabe canonical polynomial technique. The model of the system is carried out using electromechanical energy conversion princi¬ples and verified by 3-D FEM analysis. An experimental bench is built up to test the system performance under trajectory tracking and external disturbance excitation. The results confirm the effectiveness of the proposed system and the control approach to obtain a full redundant levitation even in case of disturbances. The paper demonstrates the feasibility of the con¬veyance of steel plates by using the quadruple configuration of U-shaped electromagnets and shows the merits of I-PD controller both in stabilization and increased robust levitation.

  13. Central Control and Automation Systems: A Management and Procurement Handbook. Second Edition.

    Science.gov (United States)

    Association of Physical Plant Administrators of Universities and Colleges, Washington, DC.

    It is presumed that those reading this book presently own and operate a central control and monitoring system (CCMS) or plan to implement one in the near future. One objective of this workbook is to present useful knowledge from case histories of members of the Association of Physical Plant Administrators of Universities and Colleges as well as…

  14. [Central nervous system control of energy homeostasis].

    Science.gov (United States)

    Machleidt, F; Lehnert, H

    2011-03-01

    The brain is continuously supplied with information about the distribution and amount of energy stores from the body periphery. Endocrine, autonomic and cognitive-hedonic signals are centrally integrated and exert effects on the whole organism via anabolic and catabolic pathways. The adiposity signals insulin and leptin reflect the amount of body fat and are part of a negative feedback mechanism between the periphery and the central nervous system. The hypothalamic arcuate nucleus is the most important central nervous structure, which integrates this information. Furthermore, the CNS is able to directly measure and to respond to changes in the concentration of certain nutrients. In order to develop effective therapies for the treatment of disorders of energy balance the further elucidation of these neuro-biological processes is of crucial importance. This article provides an overview of the CNS regulation of metabolism and its underlying molecular mechanisms. © Georg Thieme Verlag KG Stuttgart · New York.

  15. Optimization of the central automatic control of a small Dutch sewer system

    Science.gov (United States)

    Kolechkina, A. G.; Hoes, O. A. C.

    2012-04-01

    A sewer control system was developed in the context of a subsidized project aiming at improvement of surface water quality by control of sewer systems and surface water systems. The project was coordinated by the local water board, "Waterschap Hollandse Delta". Other participants were Delft University of Technology, Deltares and the municipalities Strijen, Cromstrijen, Westmaas, Oud Beijerland and Piershil. As part of the project there were two pilot implementations where a central automatic controller was coupled to the existing SCADA system. For these two pilots the system is now operational. A Dutch urban area in the western part of the Netherlands is usually part of a polder, which is effectively an artificially drained catchment. The urban area itself is split into small subcatchments that manage runoff in different ways. In all cases a large fraction goes into the natural hydrological cycle, but, depending on the design of the local sewer system, a larger or smaller part finds its way into the sewer system. Proper control of this flow is necessary to control surface water quality and to avoid health risks from flow from the sewer into the streets. At each time step the controller switches pumps to distribute the remaining water in the system at the end of the time step over the different subcatchments. The distribution is created based on expert judgment of the relative vulnerability and subcatchment sewer system water quality. It is implemented in terms curves of total system stored volume versus subcatchment stored volume. We describe the process of the adaptation of a controller to two different sewer systems and the understanding of the artificial part of the catchment we gained during this process. In the process of adaptation the type of sewer system (combined foul water and storm water transport or separate foul water and storm water transport) played a major role.

  16. Control integral systems; Sistemas integrales de control

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, Estrella [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1999-12-31

    Almost two third of the electric power generation in Mexico are obtained from hydrocarbons, for that reasons Comision Federal de Electricidad (CFE) dedicated special commitment in modernizing the operation of fossil fuel central stations. In attaining this objective the control systems play a fundamental roll, from them depend a good share of the reliability and the efficiency of the electric power generation process, as well as the extension of the equipment useful life. Since 1984 the Instituto de Investigaciones Electricas (IIE) has been working, upon the request of CFE, on the development of digital control systems. To date it has designed and implemented a logic control system for gas burners, which controls 32 burners of the Unit 4 boiler of the Generation Central of Valle de Mexico and two systems for distributed control for two combined cycle central stations, which are: Dos Bocas, Veracruz Combined cycle central, and Gomez Palacio, Durango combined cycle central. With these two developments the IIE enters the World tendency of implementing distributed control systems for the fossil fuel power central update [Espanol] Casi las dos terceras partes de la generacion electrica en Mexico se obtienen a partir de hidrocarburos, es por eso que la Comision Federal de Electricidad (CFE) puso especial empeno en modernizar la operacion de las centrales termoelectricas de combustibles fosiles. En el logro de este objetivo los sistemas de control desempenan un papel fundamental, de ellos depende una buena parte la confiabilidad y la eficiencia en el proceso de generacion de energia electrica, asi como la prolongacion de la vida util de los equipos. Desde 1984 el Instituto de Investigaciones Electricas (IIE) ha trabajado, a solicitud de la CFE, en el desarrollo de sistemas digitales de control. A la fecha se han disenado e implantado un sistema de control logico de quemadores de gas, el cual controla 32 quemadores de la caldera de la unidad 4 de la central de generacion

  17. Control integral systems; Sistemas integrales de control

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, Estrella [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1998-12-31

    Almost two third of the electric power generation in Mexico are obtained from hydrocarbons, for that reasons Comision Federal de Electricidad (CFE) dedicated special commitment in modernizing the operation of fossil fuel central stations. In attaining this objective the control systems play a fundamental roll, from them depend a good share of the reliability and the efficiency of the electric power generation process, as well as the extension of the equipment useful life. Since 1984 the Instituto de Investigaciones Electricas (IIE) has been working, upon the request of CFE, on the development of digital control systems. To date it has designed and implemented a logic control system for gas burners, which controls 32 burners of the Unit 4 boiler of the Generation Central of Valle de Mexico and two systems for distributed control for two combined cycle central stations, which are: Dos Bocas, Veracruz Combined cycle central, and Gomez Palacio, Durango combined cycle central. With these two developments the IIE enters the World tendency of implementing distributed control systems for the fossil fuel power central update [Espanol] Casi las dos terceras partes de la generacion electrica en Mexico se obtienen a partir de hidrocarburos, es por eso que la Comision Federal de Electricidad (CFE) puso especial empeno en modernizar la operacion de las centrales termoelectricas de combustibles fosiles. En el logro de este objetivo los sistemas de control desempenan un papel fundamental, de ellos depende una buena parte la confiabilidad y la eficiencia en el proceso de generacion de energia electrica, asi como la prolongacion de la vida util de los equipos. Desde 1984 el Instituto de Investigaciones Electricas (IIE) ha trabajado, a solicitud de la CFE, en el desarrollo de sistemas digitales de control. A la fecha se han disenado e implantado un sistema de control logico de quemadores de gas, el cual controla 32 quemadores de la caldera de la unidad 4 de la central de generacion

  18. Torque Control During Intrusion on Upper Central Incisor in Labial and Lingual bracket System - A 3D Finite Element Study.

    Science.gov (United States)

    Pol, Tejas R; Vandekar, Meghna; Patil, Anuradha; Desai, Sanjana; Shetty, Vikram; Hazarika, Saptarshi

    2018-01-01

    The aim of present study was to investigate the difference of torque control during intrusive force on upper central incisors with normal, under and high torque in lingual and labial orthodontic systems through 3D finite element analysis. Six 3D models of an upper right central incisor with different torque were designed in Solid Works 2006. Software ANSYS Version 16.0 was used to evaluate intrusive force on upper central incisor model . An intrusive force of 0.15 N was applied to the bracket slot in different torque models and the displacements along a path of nodes in the upper central incisor was assessed. On application of Intrusive force on under torqued upper central incisor in Labial system produce labial crown movement but in Lingual system caused lingual movement in the apical and incisal parts. The same intrusive force in normal-torqued central incisor led to a palatal movement in apical and labial displacement of incisal edge in Lingual system and a palatal displacement in apical area and a labial movement in the incisal edge in Labial systemin. In overtorqued upper central incisor, the labial crown displacement in Labial system is more than Lingual system. In labial and lingual system on application of the same forces in upper central incisor with different inclinations showed different responses. The magnitudes of torque Loss during intrusive loads in incisors with normal, under and over-torque were higher in Labial system than Lingual orthodontic appliances. Key words: FEM, lingual orthodontics, intrusion, torque control, labial bracket systems.

  19. A comparison of decentralized, distributed, and centralized vibro-acoustic control.

    Science.gov (United States)

    Frampton, Kenneth D; Baumann, Oliver N; Gardonio, Paolo

    2010-11-01

    Direct velocity feedback control of structures is well known to increase structural damping and thus reduce vibration. In multi-channel systems the way in which the velocity signals are used to inform the actuators ranges from decentralized control, through distributed or clustered control to fully centralized control. The objective of distributed controllers is to exploit the anticipated performance advantage of the centralized control while maintaining the scalability, ease of implementation, and robustness of decentralized control. However, and in seeming contradiction, some investigations have concluded that decentralized control performs as well as distributed and centralized control, while other results have indicated that distributed control has significant performance advantages over decentralized control. The purpose of this work is to explain this seeming contradiction in results, to explore the effectiveness of decentralized, distributed, and centralized vibro-acoustic control, and to expand the concept of distributed control to include the distribution of the optimization process and the cost function employed.

  20. Distributed control system for the FMIT

    International Nuclear Information System (INIS)

    Johnson, J.A.; Machen, D.R.; Suyama, R.M.

    1979-01-01

    The control system for the Fusion Materials Irradiation Test (FMIT) Facility will provide the primary data acquisition, control, and interface components that integrate all of the individual FMIT systems into a functional facility. The control system consists of a distributed computer network, control consoles and instrumentation subsystems. The FMIT Facility will be started, operated and secured from a Central Control Room. All FMIT systems and experimental functions will be monitored from the Central Control Room. The data acquisition and control signals will be handled by a data communications network, which connects dual computers in the Central Control Room to the microcomputers in CAMAC crates near the various subsystems of the facility

  1. Central control of thermogenesis.

    Science.gov (United States)

    Clapham, John C

    2012-07-01

    In mammals and birds, conservation of body heat at around 37 °C is vital to life. Thermogenesis is the production of this heat which can be obligatory, as in basal metabolic rate, or it can be facultative such as the response to cold. A complex regulatory system has evolved which senses environmental or core temperature and integrates this information in hypothalamic regions such as the preoptic area and dorsomedial hypothalamus. These areas then send the appropriate signals to generate and conserve heat (or dissipate it). In this review, the importance of the sympathetic nervous system is discussed in relation to its role in basal metabolic rate and adaptive thermogenesis with a particular emphasis to human obesity. The efferent sympathetic pathway does not uniformly act on all tissues; different tissues can receive different levels of sympathetic drive at the same time. This is an important concept in the discussion of the pharmacotherapy of obesity. Despite decades of work the medicine chest contains only one pill for the long term treatment of obesity, orlistat, a lipase inhibitor that prevents the absorption of lipid from the gut and is itself not systemically absorbed. The central controlling system for thermogenesis has many potential intervention points. Several drugs, previously marketed, awaiting approval or in the earlier stages of development may have a thermogenic effect via activation of the sympathetic nervous system at some point in the thermoregulatory circuit and are discussed in this review. If the balance is weighted to the "wrong" side there is the burden of increased cardiovascular risk while a shift to the "right" side, if possible, will afford a thermogenic benefit that is conducive to weight loss maintenance. This article is part of a Special Issue entitled 'Central Control Food Intake' Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. BSF control system

    International Nuclear Information System (INIS)

    Irie, Y.; Ishii, K.; Ninomiya, S.; Sasaki, H.; Sakai, I.

    1982-08-01

    The booster synchrotron utilization facility (BSF) is a facility which utilizes the four fifths of available beam pulses from the KEK booster synchrotron. The BSF control system includes the beam line control, interactions with the PS central control room and the experimental facilities, and the access control system. A brief description of the various components in the control system is given. (author)

  3. La Hague environment centralized control system

    International Nuclear Information System (INIS)

    Kalimbadjian, J.

    1991-01-01

    The purpose of this paper is to show what we are doing in the area of environmental monitoring and control in accordance with the basic principles we set out for ourselves. As we have seen, our objectives are twofold; first, to monitor the installations under normal operating conditions in accordance with the rules and within the imposed limits and, secondly, in the event of an accident involving any of the material at the plant, to determine the foreseeable consequences in order to provide the relevant authorities, who have to take the necessary measures to protect the personnel and the population, with all the help they need. Normal operation is guaranteed by effective control of liquid and gaseous discharges, by knowing the precise origin and nature of the radio-elements released and also the means of transfer leading to humans. This knowledge relies upon the interpretation of the systematic measurements which have been carried out, which can only be done by centralising and computerising the data involved. The use of third-generation radio protection equipment in combination with highly-developed computer systems has made it possible to set up a centralised environmental control station. In the event of abnormal occurrences, the software used to show the transfer of radio-elements in the air, the water, or the ground, along with the use of systematic measurements, makes it possible to determine the foreseeable consequences and to design a system of predictive monitoring. It has been possible to set up the centralised control system because of the development in computerised equipment and systems, but it has only been possible to operate this system because of the capacity of the personnel to adapt to the changeover to technology. (author)

  4. Central control of body temperature [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Shaun F. Morrison

    2016-05-01

    Full Text Available Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis.

  5. Component Control System for a Vehicle

    Science.gov (United States)

    Fraser-Chanpong, Nathan (Inventor); Spain, Ivan (Inventor); Dawson, Andrew D. (Inventor); Bluethmann, William J. (Inventor); Lee, Chunhao J. (Inventor); Vitale, Robert L. (Inventor); Guo, Raymond (Inventor); Waligora, Thomas M. (Inventor); Akinyode, Akinjide Akinniyi (Inventor); Reed, Ryan M. (Inventor)

    2016-01-01

    A vehicle includes a chassis, a modular component, and a central operating system. The modular component is supported by the chassis. The central operating system includes a component control system, a primary master controller, and a secondary master controller. The component control system is configured for controlling the modular component. The primary and secondary master controllers are in operative communication with the component control system. The primary and secondary master controllers are configured to simultaneously transmit commands to the component control system. The component control system is configured to accept commands from the secondary master controller only when a fault occurs in the primary master controller.

  6. Structural controllability and controlling centrality of temporal networks.

    Science.gov (United States)

    Pan, Yujian; Li, Xiang

    2014-01-01

    Temporal networks are such networks where nodes and interactions may appear and disappear at various time scales. With the evidence of ubiquity of temporal networks in our economy, nature and society, it's urgent and significant to focus on its structural controllability as well as the corresponding characteristics, which nowadays is still an untouched topic. We develop graphic tools to study the structural controllability as well as its characteristics, identifying the intrinsic mechanism of the ability of individuals in controlling a dynamic and large-scale temporal network. Classifying temporal trees of a temporal network into different types, we give (both upper and lower) analytical bounds of the controlling centrality, which are verified by numerical simulations of both artificial and empirical temporal networks. We find that the positive relationship between aggregated degree and controlling centrality as well as the scale-free distribution of node's controlling centrality are virtually independent of the time scale and types of datasets, meaning the inherent robustness and heterogeneity of the controlling centrality of nodes within temporal networks.

  7. Centralized Monitoring of the Microsoft Windows-based computers of the LHC Experiment Control Systems

    International Nuclear Information System (INIS)

    Varela Rodriguez, F

    2011-01-01

    The control system of each of the four major Experiments at the CERN Large Hadron Collider (LHC) is distributed over up to 160 computers running either Linux or Microsoft Windows. A quick response to abnormal situations of the computer infrastructure is crucial to maximize the physics usage. For this reason, a tool was developed to supervise, identify errors and troubleshoot such a large system. Although the monitoring of the performance of the Linux computers and their processes was available since the first versions of the tool, it is only recently that the software package has been extended to provide similar functionality for the nodes running Microsoft Windows as this platform is the most commonly used in the LHC detector control systems. In this paper, the architecture and the functionality of the Windows Management Instrumentation (WMI) client developed to provide centralized monitoring of the nodes running different flavour of the Microsoft platform, as well as the interface to the SCADA software of the control systems are presented. The tool is currently being commissioned by the Experiments and it has already proven to be very efficient optimize the running systems and to detect misbehaving processes or nodes.

  8. Centralized Monitoring of the Microsoft Windows-based computers of the LHC Experiment Control Systems

    Science.gov (United States)

    Varela Rodriguez, F.

    2011-12-01

    The control system of each of the four major Experiments at the CERN Large Hadron Collider (LHC) is distributed over up to 160 computers running either Linux or Microsoft Windows. A quick response to abnormal situations of the computer infrastructure is crucial to maximize the physics usage. For this reason, a tool was developed to supervise, identify errors and troubleshoot such a large system. Although the monitoring of the performance of the Linux computers and their processes was available since the first versions of the tool, it is only recently that the software package has been extended to provide similar functionality for the nodes running Microsoft Windows as this platform is the most commonly used in the LHC detector control systems. In this paper, the architecture and the functionality of the Windows Management Instrumentation (WMI) client developed to provide centralized monitoring of the nodes running different flavour of the Microsoft platform, as well as the interface to the SCADA software of the control systems are presented. The tool is currently being commissioned by the Experiments and it has already proven to be very efficient optimize the running systems and to detect misbehaving processes or nodes.

  9. Central Nervous System Vasculitis

    Science.gov (United States)

    ... of Vasculitis / Central Nervous System (CNS) Vasculitis Central Nervous System (CNS) Vasculitis Swap out your current Facebook Profile ... Facebook personal page. Replace with this image. Central nervous system (CNS) vasculitis is inflammation of blood vessel walls ...

  10. Upgrading the BEPC control system

    International Nuclear Information System (INIS)

    Yang Liping; Wang Lizheng; Liu Shiyao

    1992-01-01

    The BEPC control system has been put into operation and operated normally since the end of 1987. Three years's experience shows this system can satisfy basically the operation requirements, also exhibits some disadvantages araised from the original centralized system architecture based on the VAX-VCC-CAMAC, such as slow response, bottle neck of VCC, less CPU power for control etc.. This paper describes the method and procedure for upgrading the BEPC control system which will be based on DEC net and DEC-WS, and thus intend to upgrade the control system architecture from the centralized to the distributed and improve the integral system performance. (author)

  11. TFTR centralized torus interface valve control system

    International Nuclear Information System (INIS)

    Pearson, G.G.; Olsen, D.H.

    1983-01-01

    A system developed especially for the TFTR to monitor and control the interface between the vacuum vessel and associated diagnostics will be described in this paper. Diagnostics which must be connected to the machine vacuum are required to do so through a Torus Interface Valve (TIV). Two types of TIV's are used on TFTR. The first type is a non-latching valve which must be held in the opened position by a sustained OPEN command, returning automatically to the closed position when the OPEN command is removed. This type of TIV is used on all systems which never insert a probe into the vacuum vessel through the TIV. The second type of TIV is a latching valve which requires a momentary OPEN command to open and a momentary CLOSE command to close. Each TIV is linked to its own dedicated logic controller. Each logic controller is hardwired to the appropriate TIV OPEN/CLOSED limit switches, probe IN/OUT limit switches, TFTR vacuum vessel pressure setpoint switches, and diagnostic pressure setpoint switches. The logic controller can be configured for local (push-button) or remote (computer) control. Each controller has a uniquely coded keyswitch to determine the configuration. Whether under local or remote control, all OPEN and CLOSE commands must be approved by the TIV controller (TIVC). In the case of systems with probes, the controller must receive a positive indication that the probe is completely backed out before a CLOSE command will be transmitted from the TIVC to the TIV. Before a valve will be opened by a controller, the differential pressure across the valve must be within certain limits

  12. Effect of Artificial Gravity: Central Nervous System Neurochemical Studies

    Science.gov (United States)

    Fox, Robert A.; D'Amelio, Fernando; Eng, Lawrence F.

    1997-01-01

    The major objective of this project was to assess chemical and morphological modifications occurring in muscle receptors and the central nervous system of animals subjected to altered gravity (2 x Earth gravity produced by centrifugation and simulated micro gravity produced by hindlimb suspension). The underlying hypothesis for the studies was that afferent (sensory) information sent to the central nervous system by muscle receptors would be changed in conditions of altered gravity and that these changes, in turn, would instigate a process of adaptation involving altered chemical activity of neurons and glial cells of the projection areas of the cerebral cortex that are related to inputs from those muscle receptors (e.g., cells in the limb projection areas). The central objective of this research was to expand understanding of how chronic exposure to altered gravity, through effects on the vestibular system, influences neuromuscular systems that control posture and gait. The project used an approach in which molecular changes in the neuromuscular system were related to the development of effective motor control by characterizing neurochemical changes in sensory and motor systems and relating those changes to motor behavior as animals adapted to altered gravity. Thus, the objective was to identify changes in central and peripheral neuromuscular mechanisms that are associated with the re-establishment of motor control which is disrupted by chronic exposure to altered gravity.

  13. Remembering the Future of Centralized Control-Decentralized Execution

    National Research Council Canada - National Science Library

    Sheets, Patrick

    2003-01-01

    ... concepts which should drive system development. To realize the significance of the USAF C2 tenet of "centralized control-decentralized execution," one must understand how C2 is executed, in contingency theaters of operation...

  14. Deficits of anticipatory grip force control after damage to peripheral and central sensorimotor systems.

    Science.gov (United States)

    Hermsdörfer, Joachim; Hagl, Elke; Nowak, Dennis A

    2004-11-01

    Healthy subjects adjust their grip force economically to the weight of a hand-held object. In addition, inertial loads, which arise from arm movements with the grasped object, are anticipated by parallel grip force modulations. Internal forward models have been proposed to predict the consequences of voluntary movements. Anesthesia of the fingers impairs grip force economy but the feedforward character of the grip force/load coupling is preserved. To further analyze the role of sensory input for internal forward models and to characterize the consequences of central nervous system damage for anticipatory grip force control, we measured grip force behavior in neurological patients. We tested a group of stroke patients with varying degrees of impaired fine motor control and sensory loss, a single patient with complete and permanent differentation from all tactile and proprioceptive input, and a group of patients with amyotrophic lateral sclerosis (ALS) that exclusively impairs the motor system without affecting sensory modalities. Increased grip forces were a common finding in all patients. Sensory deficits were a strong but not the only predictor of impaired grip force economy. The feedforward mode of grip force control was typically preserved in the stroke patients despite their central sensory deficits, but was severely disturbed in the patient with peripheral sensory deafferentation and in a minority of stroke patients. Moderate deficits of feedforward control were also obvious in ALS patients. Thus, the function of the internal forward model and the precision of grip force production may depend on a complex anatomical and functional network of sensory and motor structures and their interaction in time and space.

  15. Demand management through centralized control system using power line communication for existing buildings

    International Nuclear Information System (INIS)

    Al-Mulla, A.; ElSherbini, A.

    2014-01-01

    Highlights: • A pilot system was developed for demand management of equipment in buildings. • The networking was based on LonWorks platform and power line communication. • Demand strategies led to load reductions up to 74% and energy savings up to 25%. • The peak load reduction is expected to reach 3.44 GW by the year 2030. - Abstract: Managing peak demand efficiently is vital for maintaining uninterrupted supply of electrical power by utility providers. In this work, a pilot system was developed for managing and controlling the demand of major power consuming equipment in buildings from a central server, while relying mostly on existing infrastructure and maintaining consumer comfort. The system was successfully demonstrated on a selected group of buildings using the LonWorks networking platform. At the building level, the system utilized power line and twisted pair communication to control the thermostats of air-conditioning (A/C) units. The higher level communication was executed through extensible markup language (XML) and simple object access protocol (SOAP). The system provided control capabilities based on A/C unit priority, thermostat temperature, building type and geographic location. The development and execution of demand management strategies for selected buildings led to peak load reductions up to 74%, in addition to energy savings up to 25%. Implementing such a system at a national level in Kuwait is estimated to reduce peak demand by 3.44 GW, amounting to capital savings of $4.13 billion. The use of existing infrastructure reduced the cost and installation time of the system. Based on the successful testing of this pilot system, a larger-scale system is being developed

  16. Central and peripheral control of food intake

    Directory of Open Access Journals (Sweden)

    Abdalla M. M. I.

    2017-01-01

    Full Text Available The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. The obesity has an evil effect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake. Centrally, the food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals. Comprehension of the signals that control food intake and energy balance may open a new therapeutic approaches directed against the obesity and its associated complications, as is the insulin resistance and others. In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity.

  17. Central and peripheral control of food intake.

    Science.gov (United States)

    Abdalla, M M I

    2017-01-01

    The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. The obesity has an evil effect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake. Centrally, the food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals. Comprehension of the signals that control food intake and energy balance may open a new therapeutic approaches directed against the obesity and its associated complications, as is the insulin resistance and others. In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity.

  18. Optimal centralized and decentralized velocity feedback control on a beam

    International Nuclear Information System (INIS)

    Engels, W P; Elliott, S J

    2008-01-01

    This paper considers the optimization of a velocity feedback controller with a collocated force actuator, to minimize the kinetic energy of a simply supported beam. If the beam is excited at a single location, the optimum feedback gain varies with the position of the control system. It is shown that this variation depends partly on the location of the control force relative to the exciting force. If a distributed excitation is assumed, that is random in both time and space, a unique optimum value of the feedback gain can be found for a given control location. The effect of the control location on performance and the optimal feedback gain can then be examined and is found to be limited provided the control locations are not close to the ends of the beam. The optimization can also be performed for a multichannel velocity feedback system. Both a centralized and a decentralized controller are considered. It is shown that the difference in performance between a centralized and a decentralized controller is small, unless the control locations are closely spaced. In this case the centralized controller effectively feeds back a moment proportional to angular velocity as well as a force proportional to a velocity. It is also shown that the optimal feedback gain can be approximated on the basis of a limited model and that similar results can be achieved

  19. The Design and Implementation of the Remote Centralized-Monitoring System of Well-Control Equipment Based on RFID Technique

    Directory of Open Access Journals (Sweden)

    Luo Bin

    2017-01-01

    Full Text Available At present, in domestic for the management of well control equipment continue to the traditional way of nameplates identifies and paper-based registration, there are many issues like the separation of data information of device, easy lose, difficult query, confused management and many other problems, which will make the problem device into the well field, and then resulting in well control runaway drilling accident. To solve the above problems, this paper put forward to the integrated remote centralized-monitoring management mode of the well-control equipment. Taking the advantages of IOT technology, adopting the RFID technology, and combining with the remote transmission, this paper designs the remote centralized-monitoring system of well-control equipment based on RFID, which realizes the intelligent management of well-control equipment and meets the actual demand of the well-control equipment safe use and timely scheduling, and it has the ability of field application.

  20. Wisdom Appliance Control System

    Science.gov (United States)

    Hendrick; Jheng, Jyun-Teng; Tsai, Chen-Chai; Liou, Jia-Wei; Wang, Zhi-Hao; Jong, Gwo-Jia

    2017-07-01

    Intelligent appliances wisdom involves security, home care, convenient and energy saving, but the home automation system is still one of the core unit, and also using micro-processing electronics technology to centralized and control the home electrical products and systems, such as: lighting, television, fan, air conditioning, stereo, it composed of front-controller systems and back-controller panels, user using front-controller to control command, and then through the back-controller to powered the device.

  1. APE (state-oriented approach) centralized control procedures

    International Nuclear Information System (INIS)

    Astier, D.; Depont, G.; Van Dermarliere, Y.

    2004-01-01

    This article presents the progressive implementation of the state-oriented approach (APE) for centralized control procedures in French nuclear power plants. The implementation began in the years 1982-83 and it concerned only the circuits involved in engineered safeguard systems such IS (safety injection), EAS (containment spray system) and GMPP (reactor coolant pump set). In 2003 the last PWR unit switched from the event oriented approach to APE for post-accidental situations

  2. Thyroid hormone and the central control of homeostasis.

    Science.gov (United States)

    Warner, Amy; Mittag, Jens

    2012-08-01

    It has long been known that thyroid hormone has profound direct effects on metabolism and cardiovascular function. More recently, it was shown that the hormone also modulates these systems by actions on the central autonomic control. Recent studies that either manipulated thyroid hormone signalling in anatomical areas of the brain or analysed seasonal models with an endogenous fluctuation in hypothalamic thyroid hormone levels revealed that the hormone controls energy turnover. However, most of these studies did not progress beyond the level of anatomical nuclei; thus, the neuronal substrates as well as the molecular mechanisms remain largely enigmatic. This review summarises the evidence for a role of thyroid hormone in the central autonomic control of peripheral homeostasis and advocates novel strategies to address thyroid hormone action in the brain on a cellular level.

  3. Controlling centrality in complex networks

    Science.gov (United States)

    Nicosia, V.; Criado, R.; Romance, M.; Russo, G.; Latora, V.

    2012-01-01

    Spectral centrality measures allow to identify influential individuals in social groups, to rank Web pages by popularity, and even to determine the impact of scientific researches. The centrality score of a node within a network crucially depends on the entire pattern of connections, so that the usual approach is to compute node centralities once the network structure is assigned. We face here with the inverse problem, that is, we study how to modify the centrality scores of the nodes by acting on the structure of a given network. We show that there exist particular subsets of nodes, called controlling sets, which can assign any prescribed set of centrality values to all the nodes of a graph, by cooperatively tuning the weights of their out-going links. We found that many large networks from the real world have surprisingly small controlling sets, containing even less than 5 – 10% of the nodes. PMID:22355732

  4. A new conception for the central control facility of MEA

    International Nuclear Information System (INIS)

    Schimmel, F.

    1986-01-01

    To control the AFBU from the Central Control Facility some change will be necessary. This has led to a complete revision of the facilities of both consoles. Some proposals are made to improve the response time of the control systems. These improvements are feasible at short notice. (G.J.P.)

  5. Central system of Interlock of ITER, high integrity architecture

    International Nuclear Information System (INIS)

    Prieto, I.; Martinez, G.; Lopez, C.

    2014-01-01

    The CIS (Central Interlock System), along with the CODAC system and CSS (Central Safety System), form the central I and C systems of ITER. The CIS is responsible for implementing the core functions of protection (Central Interlock Functions) through different systems of plant (Plant Systems) within the overall strategy of investment protection for ITER. IBERDROLA supports engineering to define and develop the control architecture of CIS according to the stringent requirements of integrity, availability and response time. For functions with response times of the order of half a second is selected PLC High availability of industrial range. However, due to the nature of the machine itself, certain functions must be able to act under the millisecond, so it has had to develop a solution based on FPGA (Field Programmable Gate Array) capable of meeting the requirements architecture. In this article CIS architecture is described, as well as the process for the development and validation of the selected platforms. (Author)

  6. Centralization and decentralization in energy systems and associated risks

    International Nuclear Information System (INIS)

    Rehm, W.; Schinner, F.; Kromp, W.

    1998-01-01

    Full text of publication follows: the concept of centralization/decentralization is - considering its widespread use - surprisingly ill-defined. Within the SERF-program (Socio Economic Research on Fusion) an attempt is made to clarify the complex issue of centralization/decentralization and to analyze its expected interaction with electricity production system in the case of nuclear fusion. Fusion research at the time is a multinational, highly centralized undertaking. As a result of this, and due to the expected large energy production units, it is generally expected that fusion will be embedded in a highly centralized, international energy supply system. The degree of centralization of an energy supply system, however, is believed to have for reaching consequences on the stability of the system, and beyond that, on decision making processes in energy policy, as well as democratic structures on the national or even international level. Internationalization might require control instruments that do not exist so far. Amongst other reservations, it is the possibly unwanted consequences of such a highly centralized, international energy supply system that limit acceptance of the fusion technology in the public. Therefore, centralization and decentralization trends of energy supply systems over the years are being looked at, to study their influence on the political and social systems (and vice-versa). In a first step, an attempt is made to classify centralization. Careful analyses and evaluation of available literature revealed a broad spectrum of different forms and degrees of centralization. Various parameters describing energy production and distribution are used. A differentiation of centralization on a technical and on an organizational level seems necessary, although they are not fully independent of each other. Beyond this, the choice of parameters must depend on the questions to be addressed. A new approach defining different levels and degrees of

  7. Centralization and decentralization in energy systems and associated risks

    Energy Technology Data Exchange (ETDEWEB)

    Rehm, W.; Schinner, F.; Kromp, W. [Vienna Univ., Institute of Risk Research, IRR (Austria)

    1998-07-01

    Full text of publication follows: the concept of centralization/decentralization is - considering its widespread use - surprisingly ill-defined. Within the SERF-program (Socio Economic Research on Fusion) an attempt is made to clarify the complex issue of centralization/decentralization and to analyze its expected interaction with electricity production system in the case of nuclear fusion. Fusion research at the time is a multinational, highly centralized undertaking. As a result of this, and due to the expected large energy production units, it is generally expected that fusion will be embedded in a highly centralized, international energy supply system. The degree of centralization of an energy supply system, however, is believed to have for reaching consequences on the stability of the system, and beyond that, on decision making processes in energy policy, as well as democratic structures on the national or even international level. Internationalization might require control instruments that do not exist so far. Amongst other reservations, it is the possibly unwanted consequences of such a highly centralized, international energy supply system that limit acceptance of the fusion technology in the public. Therefore, centralization and decentralization trends of energy supply systems over the years are being looked at, to study their influence on the political and social systems (and vice-versa). In a first step, an attempt is made to classify centralization. Careful analyses and evaluation of available literature revealed a broad spectrum of different forms and degrees of centralization. Various parameters describing energy production and distribution are used. A differentiation of centralization on a technical and on an organizational level seems necessary, although they are not fully independent of each other. Beyond this, the choice of parameters must depend on the questions to be addressed. A new approach defining different levels and degrees of

  8. A 200kW central receiver CPV system

    Energy Technology Data Exchange (ETDEWEB)

    Lasich, John, E-mail: jbl@raygen.com; Thomas, Ian, E-mail: ithomas@raygen.com; Hertaeg, Wolfgang; Shirley, David; Faragher, Neil; Erenstrom, Neil; Carter, Sam; Cox, Brian; Zuo, Xinyi [Raygen Resources Pty. Ltd., 15 King Street, Blackburn, Victoria, 3130 (Australia)

    2015-09-28

    Raygen Resources has recently completed a Central Receiver CPV (CSPV) pilot plant in Central Victoria, Australia. The system is under final commissioning and initial operation is expected in late April 2015. The pilot demonstrates a full scale CSPV repeatable unit in a form that is representative of a commercial product and provides a test bed to prove out performance and reliability of the CSPV technology. Extensive testing of the system key components: dense array module, wireless solar powered heliostat and control system has been performed in the laboratory and on sun. Results from this key component testing are presented herein.

  9. Microgrid Central Controller Development and Hierarchical Control Implementation in the Intelligent MicroGrid Lab of Aalborg University

    DEFF Research Database (Denmark)

    Meng, Lexuan; Savaghebi, Mehdi; Andrade, Fabio

    2015-01-01

    This paper presents the development of a microgrid central controller in an inverter-based intelligent microgrid (iMG) lab in Aalborg University, Denmark. The iMG lab aims to provide a flexible experimental platform for comprehensive studies of microgrids. The complete control system applied...... in this lab is based on the hierarchical control scheme for microgrids and includes primary, secondary and tertiary control. The structure of the lab, including the lab facilities, configurations and communication network, is first introduced. Primary control loops are developed in MATLAB....../Simulink and compiled to dSPACEs for local control purposes. In order to realize system supervision and proper secondary and tertiary management, a LabVIEW-based microgrid central controller is also developed. The software and hardware schemes are described. An example case is introduced and tested in the iMG lab...

  10. Centralized digital computer control of a research nuclear reactor

    International Nuclear Information System (INIS)

    Crawford, K.C.

    1987-01-01

    A hardware and software design for the centralized control of a research nuclear reactor by a digital computer are presented, as well as an investigation of automatic-feedback control. Current reactor-control philosophies including redundancy, inherent safety in failure, and conservative-yet-operational scram initiation were used as the bases of the design. The control philosophies were applied to the power-monitoring system, the fuel-temperature monitoring system, the area-radiation monitoring system, and the overall system interaction. Unlike the single-function analog computers currently used to control research and commercial reactors, this system will be driven by a multifunction digital computer. Specifically, the system will perform control-rod movements to conform with operator requests, automatically log the required physical parameters during reactor operation, perform the required system tests, and monitor facility safety and security. Reactor power control is based on signals received from ion chambers located near the reactor core. Absorber-rod movements are made to control the rate of power increase or decrease during power changes and to control the power level during steady-state operation. Additionally, the system incorporates a rudimentary level of artificial intelligence

  11. A comparison of the economic benefits of centralized and distributed model predictive control strategies for optimal and sub-optimal mine dewatering system designs

    International Nuclear Information System (INIS)

    Romero, Alberto; Millar, Dean; Carvalho, Monica; Maestre, José M.; Camacho, Eduardo F.

    2015-01-01

    Mine dewatering can represent up to 5% of the total energy demand of a mine, and is one of the mine systems that aim to guarantee safe operating conditions. As mines go deeper, dewatering pumping heads become bigger, potentially involving several lift stages. Greater depth does not only mean greater dewatering cost, but more complex systems that require more sophisticated control systems, especially if mine operators wish to gain benefits from demand response incentives that are becoming a routine part of electricity tariffs. This work explores a two stage economic optimization procedure of an underground mine dewatering system, comprising two lifting stages, each one including a pump station and a water reservoir. First, the system design is optimized considering hourly characteristic dewatering demands for twelve days, one day representing each month of the year to account for seasonal dewatering demand variations. This design optimization minimizes the annualized cost of the system, and therefore includes the investment costs in underground reservoirs. Reservoir size, as well as an hourly pumping operation plan are calculated for specific operating environments, defined by characteristic hourly electricity prices and water inflows (seepage and water use from production activities), at best known through historical observations for the previous year. There is no guarantee that the system design will remain optimal when it faces the water inflows and market determined electricity prices of the year ahead, or subsequent years ahead, because these remain unknown at design time. Consequently, the dewatering optimized system design is adopted subsequently as part of a Model Predictive Control (MPC) strategy that adaptively maintains optimality during the operations phase. Centralized, distributed and non-centralized MPC strategies are explored. Results show that the system can be reliably controlled using any of these control strategies proposed. Under the operating

  12. Lyapunov-Based Control Scheme for Single-Phase Grid-Connected PV Central Inverters

    NARCIS (Netherlands)

    Meza, C.; Biel, D.; Jeltsema, D.; Scherpen, J. M. A.

    A Lyapunov-based control scheme for single-phase single-stage grid-connected photovoltaic central inverters is presented. Besides rendering the closed-loop system globally stable, the designed controller is able to deal with the system uncertainty that depends on the solar irradiance. A laboratory

  13. The Development of a Framework for Target Diagnostic Centralized Control System (TDCCS) in ICF Experiments

    International Nuclear Information System (INIS)

    Zhang Chi; Wang Jian; Yu Xiaoqi; Yang Dong

    2008-01-01

    A framework for target diagnostic centralized control system (TDCCS) in inertial confinement fusion (ICF) experiment has been developed. The developed framework is based on the common object request broker architecture (CORBA) standard and part of the concept from the ICFRoot (a framework based on ROOT for ICF experiments) framework design. This framework is of a component architecture, including a message bus, command executer, status processor, parser and proxy. To test the function of the framework, a simplified prototype of the TDCCS has been developed as well.

  14. Simulation of CIFF (Centralized IFF) remote control displays

    Science.gov (United States)

    Tucker, D. L.; Leibowitz, L. M.

    1986-06-01

    This report presents the software simulation of the Remote-Control-Display (RCS) proposed to be used in the Centralized IFF (CIFF) system. A description of the simulation programs along with simulated menu formats are presented. A sample listing of the simulation programs and a brief description of the program operation are also included.

  15. Research and application of an intelligent control system in central air-conditioning based on energy consumption simulation

    Science.gov (United States)

    Cao, Ling; Che, Wenbin

    2018-05-01

    For the central air-conditioning energy-saving, it is common practice to use a wide range of PTD controllers in engineering to optimize energy savings. However, the shortcomings of the PTD controller have also been magnified on this issue, such as: calculation accuracy is not enough, the calculation time is too long. Particle swarm optimization has the advantage of fast convergence. This paper is based on Particle Swarm Optimization apply in PTD controller tuning parameters in order to achieve the purpose of saving energy while ensuring comfort. The algorithm proposed in this paper can adjust the weight according to the change of population fitness, reduce the weights of particles with lower fitness and enhance the weights of particles with higher fitness in the population, and fully release the population vitality. The method in this paper is validated by the TRNSYS model based on the central air-conditioning system. The experimental results show that the room temperature fluctuation is small, the overshoot is small, the adjustment speed is fast, and the energy-saving fluctuates at 10%.

  16. The frontoparietal control system: A central role in mental health

    Science.gov (United States)

    Cole, Michael W.; Repovs, Grega; Anticevic, Alan

    2014-01-01

    Recent findings suggest the existence of a frontoparietal control system consisting of ‘flexible hubs’ that regulate distributed systems (e.g., visual, limbic, motor) according to current task goals. A growing number of studies are reporting alterations of this control system across a striking range of mental diseases. We suggest this may reflect a critical role for the control system in promoting and maintaining mental health. Specifically, we propose that this system implements feedback control to regulate symptoms as they arise (e.g., excessive anxiety reduced via regulation of amygdala), such that an intact control system is protective against a variety of mental illnesses. Consistent with this possibility, recent results indicate that several major mental illnesses involve altered brain-wide connectivity of the control system, likely altering its ability to regulate symptoms. These results suggest that this ‘immune system of the mind’ may be an especially important target for future basic and clinical research. PMID:24622818

  17. A silicon central pattern generator controls locomotion in vivo.

    Science.gov (United States)

    Vogelstein, R J; Tenore, F; Guevremont, L; Etienne-Cummings, R; Mushahwar, V K

    2008-09-01

    We present a neuromorphic silicon chip that emulates the activity of the biological spinal central pattern generator (CPG) and creates locomotor patterns to support walking. The chip implements ten integrate-and-fire silicon neurons and 190 programmable digital-to-analog converters that act as synapses. This architecture allows for each neuron to make synaptic connections to any of the other neurons as well as to any of eight external input signals and one tonic bias input. The chip's functionality is confirmed by a series of experiments in which it controls the motor output of a paralyzed animal in real-time and enables it to walk along a three-meter platform. The walking is controlled under closed-loop conditions with the aide of sensory feedback that is recorded from the animal's legs and fed into the silicon CPG. Although we and others have previously described biomimetic silicon locomotor control systems for robots, this is the first demonstration of a neuromorphic device that can replace some functions of the central nervous system in vivo.

  18. Conductive polymers for controlled release and treatment of central nervous system injury

    Science.gov (United States)

    Saigal, Rajiv

    As one of the most devastating forms of neurotrauma, spinal cord injury remains a challenging clinical problem. The difficulties in treatment could potentially be resolved by better technologies for therapeutic delivery. In order to develop new approaches to treating central nervous system injury, this dissertation focused on using electrically-conductive polymers, controlled drug release, and stem cell transplantation. We first sought to enhance the therapeutic potential of neural stem cells by electrically increasing their production of neurotrophic factors (NTFs), important molecules for neuronal cell survival, differentiation, synaptic development, plasticity, and growth. We fabricated a new cell culture device for growing neural stem cells on a biocompatible, conductive polymer. Electrical stimulation via the polymer led to upregulation of NTF production by neural stem cells. This approach has the potential to enhance stem cell function while avoiding the pitfalls of genetic manipulation, possibly making stem cells more viable as a clinical therapy. Seeing the therapeutic potential of conductive polymers, we extended our studies to an in vivo model of spinal cord injury (SCI). Using a novel fabrication and extraction technique, a conductive polymer was fabricated to fit to the characteristic pathology that follows contusive SCI. Assessed via quantitative analysis of MR images, the conductive polymer significantly reduced compression of the injured spinal cord. Further characterizing astroglial and neuronal response of injured host tissue, we found significant neuronal sparing as a result of this treatment. The in vivo studies also demonstrated improved locomotor recovery mediated by a conductive polymer scaffold over a non-conductive control. We next sought to take advantage of conductive polymers for local, electronically-controlled release of drugs. Seeking to overcome reported limitations in drug delivery via polypyrrole, we first embedded drugs in poly

  19. Droop-free Team-oriented Control for AC Distribution Systems

    DEFF Research Database (Denmark)

    Nasirian, Vahidreza; Shafiee, Qobad; Guerrero, Josep M.

    2015-01-01

    Droop control is conventionally used for load sharing in AC distribution systems. Despite decentralized nature of the droop technique, it requires centralized secondary control to provide voltage and frequency regulation across the system. Distributed control, as an alternative to the centralized...

  20. The Central Nervous System and Bone Metabolism: An Evolving Story.

    Science.gov (United States)

    Dimitri, Paul; Rosen, Cliff

    2017-05-01

    Our understanding of the control of skeletal metabolism has undergone a dynamic shift in the last two decades, primarily driven by our understanding of energy metabolism. Evidence demonstrating that leptin not only influences bone cells directly, but that it also plays a pivotal role in controlling bone mass centrally, opened up an investigative process that has changed the way in which skeletal metabolism is now perceived. Other central regulators of bone metabolism have since been identified including neuropeptide Y (NPY), serotonin, endocannabinoids, cocaine- and amphetamine-regulated transcript (CART), adiponectin, melatonin and neuromedin U, controlling osteoblast and osteoclast differentiation, proliferation and function. The sympathetic nervous system was originally identified as the predominant efferent pathway mediating central signalling to control skeleton metabolism, in part regulated through circadian genes. More recent evidence points to a role of the parasympathetic nervous system in the control of skeletal metabolism either through muscarinic influence of sympathetic nerves in the brain or directly via nicotinic receptors on osteoclasts, thus providing evidence for broader autonomic skeletal regulation. Sensory innervation of bone has also received focus again widening our understanding of the complex neuronal regulation of bone mass. Whilst scientific advance in this field of bone metabolism has been rapid, progress is still required to understand how these model systems work in relation to the multiple confounders influencing skeletal metabolism, and the relative balance in these neuronal systems required for skeletal growth and development in childhood and maintaining skeletal integrity in adulthood.

  1. Randomized Double-Blind Placebo-Controlled Trial of Bevacizumab Therapy for Radiation Necrosis of the Central Nervous System

    International Nuclear Information System (INIS)

    Levin, Victor A.; Bidaut, Luc; Hou, Ping; Kumar, Ashok J.; Wefel, Jeffrey S.; Bekele, B. Nebiyou; Prabhu, Sujit; Loghin, Monica; Gilbert, Mark R.; Jackson, Edward F.

    2011-01-01

    Purpose: To conduct a controlled trial of bevacizumab for the treatment of symptomatic radiation necrosis of the brain. Methods and Materials: A total of 14 patients were entered into a placebo-controlled randomized double-blind study of bevacizumab for the treatment of central nervous system radiation necrosis. All patients were required to have radiographic or biopsy proof of central nervous system radiation necrosis and progressive neurologic symptoms or signs. Eligible patients had undergone irradiation for head-and-neck carcinoma, meningioma, or low- to mid-grade glioma. Patients were randomized to receive intravenous saline or bevacizumab at 3-week intervals. The magnetic resonance imaging findings 3 weeks after the second treatment and clinical signs and symptoms defined the response or progression. Results: The volumes of necrosis estimated on T 2 -weighted fluid-attenuated inversion recovery and T 1 -weighted gadolinium-enhanced magnetic resonance imaging scans demonstrated that although no patient receiving placebo responded (0 of 7), all bevacizumab-treated patients did so (5 of 5 randomized and 7 of 7 crossover) with decreases in T 2 -weighted fluid-attenuated inversion recovery and T 1 -weighted gadolinium-enhanced volumes and a decrease in endothelial transfer constant. All bevacizumab-treated patients-and none of the placebo-treated patients-showed improvement in neurologic symptoms or signs. At a median of 10 months after the last dose of bevacizumab in patients receiving all four study doses, only 2 patients had experienced a recurrence of magnetic resonance imaging changes consistent with progressive radiation necrosis; one patient received a single additional dose of bevacizumab and the other patient received two doses. Conclusion: The Class I evidence of bevacizumab efficacy from the present study in the treatment of central nervous system radiation necrosis justifies consideration of this treatment option for people with radiation necrosis

  2. Diverse roles of neurotensin agonists in the central nervous system

    Directory of Open Access Journals (Sweden)

    Mona eBoules

    2013-03-01

    Full Text Available NT is a tridecapeptide that is found in the central nervous system and the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in the gut. Additionally, NT acts as a neuromodulator to several neurotransmitter systems including dopaminergic, sertonergic, GABAergic, glutamatergic and cholinergic systems. Due to its association with such a wide variety of neurotransmitters, NT has been implicated in the pathophysiology of several central nervous system (CNS disorders such as schizophrenia, drug abuse, Parkinson’s disease, pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation. The present review will focus on the role that NT and its analogs play in schizophrenia, endocrine function, pain, psychostimulant abuse, and Parkinson’s disease.

  3. Hybrid centralized-distributed power conditioning system for thermoelectric generator with high energy efficiency

    DEFF Research Database (Denmark)

    Wu, Hongfei; Sun, Kai; Chen, Min

    2013-01-01

    the proposed system, which benefits for implementing high MPPT efficiency and high conversion efficiency simultaneously. A hybrid MPPT control strategy is proposed for this HCD power conditioning system. The characteristics, circuit implementation and operation principles of the proposed system are presented......-distributed (HCD) power conditioning system for TEG and its control strategy are proposed in this paper. The HCD power conditioning system is composed by a centralized power conversion stage and multiple distributed power conversion stages. Most of the power is processed by the centralized power conversion stage...

  4. Simplified system for the pressure control of a Nucleo electric central of the BWR type

    International Nuclear Information System (INIS)

    Sanchez J, J.

    2003-01-01

    One of the main preoccupations of the electric power generator stations is the appropriate operation of the same ones. The operators must be qualified to respond in an adequate way and to be able to take to these power stations to an optimal, sure and stable operation condition under any circumstance. The Laboratory of Analysis in Nuclear Reactors Engineering (LAIRN) of the Engineering Faculty of UNAM (Fl) in collaboration with the International Atomic Energy Agency (IAEA), it develops an interactive classroom simulator in which simulations of the phenomena which take place in a nuclear power station are executed. The classroom simulator bases its operation on specialized nuclear codes feeding interactive graphic unfolding with those that it is possible to make a monitoring, supervision and control of the behavior of the power station under any operation regime, either in normal operation, transitory events or postulated accident sequence. The development of this classroom simulator includes a modular and re configurable structure. Due to it is indispensable to count with a higher inter activity with the system it is included the simulation of the control system of the plant and inside the same, one of those more important it is the reactor pressure control system. The present work describes the conceptual design and the used methodology for the development and implementation in the simulator of a simplified model of the pressure control system for a BWR generic central. The reach of the development will allow to accomplish the necessary tests to demonstrate that this has an adequate performance according to the carried out simplifications. (Author)

  5. Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

    NARCIS (Netherlands)

    Febvey, Olivia; Schüz, Joachim; Bailey, Helen D; Clavel, Jacqueline; Lacour, Brigitte; Orsi, Laurent; Lightfoot, Tracy; Roman, Eve; Vermeulen, Roel; Kromhout, Hans; Olsson, Ann

    2016-01-01

    OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure. METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15

  6. Machine Control System of Steady State Superconducting Tokamak-1

    Energy Technology Data Exchange (ETDEWEB)

    Masand, Harish, E-mail: harish@ipr.res.in; Kumar, Aveg; Bhandarkar, M.; Mahajan, K.; Gulati, H.; Dhongde, J.; Patel, K.; Chudasma, H.; Pradhan, S.

    2016-11-15

    Highlights: • Central Control System. • SST-1. • Machine Control System. - Abstract: Central Control System (CCS) of the Steady State Superconducting Tokamak-1 (SST-1) controls and monitors around 25 plant and experiment subsystems of SST-1 located remotely from the Central-Control room. Machine Control System (MCS) is a supervisory system that sits on the top of the CCS hierarchy and implements the CCS state diagram. MCS ensures the software interlock between the SST-1 subsystems with the CCS, any subsystem communication failure or its local error does not prohibit the execution of the MCS and in-turn the CCS operation. MCS also periodically monitors the subsystem’s status and their vital process parameters throughout the campaign. It also provides the platform for the Central Control operator to visualize and exchange remotely the operational and experimental configuration parameters with the sub-systems. MCS remains operational 24 × 7 from the commencement to the termination of the SST-1 campaign. The developed MCS has performed robustly and flawlessly during all the last campaigns of SST-1 carried out so far. This paper will describe various aspects of the development of MCS.

  7. Filtering and control of wireless networked systems

    CERN Document Server

    Zhang, Dan; Yu, Li

    2017-01-01

    This self-contained book, written by leading experts, offers a cutting-edge, in-depth overview of the filtering and control of wireless networked systems. It addresses the energy constraint and filter/controller gain variation problems, and presents both the centralized and the distributed solutions. The first two chapters provide an introduction to networked control systems and basic information on system analysis. Chapters (3–6) then discuss the centralized filtering of wireless networked systems, presenting different approaches to deal with energy efficiency and filter/controller gain variation problems. The next part (chapters 7–10) explores the distributed filtering of wireless networked systems, addressing the main problems of energy constraint and filter gain variation. The final part (chapters 11–14) focuses on the distributed control of wireless networked systems. systems for communication and control applications, the bo...

  8. The carbon storage regulator (Csr) system exerts a nutrient-specific control over central metabolism in Escherichia coli strain Nissle 1917.

    Science.gov (United States)

    Revelles, Olga; Millard, Pierre; Nougayrède, Jean-Philippe; Dobrindt, Ulrich; Oswald, Eric; Létisse, Fabien; Portais, Jean-Charles

    2013-01-01

    The role of the post-transcriptional carbon storage regulator (Csr) system in nutrient utilization and in the control of the central metabolism in E. coli reference commensal strain Nissle 1917 was investigated. Analysis of the growth capabilities of mutants altered for various components of the Csr system (csrA51, csrB, csrC and csrD mutations) showed that only the protein CsrA - the key component of the system - exerts a marked role in carbon nutrition. Attenuation of CsrA activity in the csrA51 mutant affects the growth efficiency on a broad range of physiologically relevant carbon sources, including compounds utilized by the Entner-Doudoroff (ED) pathway. Detailed investigations of the metabolomes and fluxomes of mutants and wild-type cells grown on carbon sources representative of glycolysis and of the ED pathway (glucose and gluconate, respectively), revealed significant re-adjusting of central carbon metabolism for both compounds in the csrA51 mutant. However, the metabolic re-adjusting observed on gluconate was strikingly different from that observed on glucose, indicating a nutrient-specific control of metabolism by the Csr system.

  9. Communication systems in JT-60 control

    International Nuclear Information System (INIS)

    Kimura, T.; Hosogane, N.; Kondo, I.; Kumahara, T.; Kurihara, K.; Yonekawa, I.; Yoshino, R.

    1983-01-01

    A new concept in communication is applied to the JT-60 control system which handles a large amount of data for the plant support and monitoring and for the discharge control including plasma feedback control. The communication systems are characterized by 1) adoption of an efficient protocol in the central highways which are composed of dual serial CAMAC ones, 2) standardization of the protocol and data format between the central controller and each subsystem one, 3) adoption of a polling method for plant monitoring and of block transfer for discharge conditions and results, and 4) use of novel modules for the fast data transfer in the real-time systems. A compact tool has also been developed for testing the data communication

  10. Information management system breadboard data acquisition and control system.

    Science.gov (United States)

    Mallary, W. E.

    1972-01-01

    Description of a breadboard configuration of an advanced information management system based on requirements for high data rates and local and centralized computation for subsystems and experiments to be housed on a space station. The system is to contain a 10-megabit-per-second digital data bus, remote terminals with preprocessor capabilities, and a central multiprocessor. A concept definition is presented for the data acquisition and control system breadboard, and a detailed account is given of the operation of the bus control unit, the bus itself, and the remote acquisition and control unit. The data bus control unit is capable of operating under control of both its own test panel and the test processor. In either mode it is capable of both single- and multiple-message operation in that it can accept a block of data requests or update commands for transmission to the remote acquisition and control unit, which in turn is capable of three levels of data-handling complexity.

  11. Central gain control in tinnitus and hyperacusis

    Directory of Open Access Journals (Sweden)

    Benjamin D Auerbach

    2014-10-01

    Full Text Available Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders.

  12. Central Gain Control in Tinnitus and Hyperacusis

    Science.gov (United States)

    Auerbach, Benjamin D.; Rodrigues, Paulo V.; Salvi, Richard J.

    2014-01-01

    Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders. PMID:25386157

  13. Comprehensive Craniospinal Radiation for Controlling Central Nervous System Leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Gary V.; Shihadeh, Ferial [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kantarjian, Hagop [Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Allen, Pamela [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Rondon, Gabriela; Kebriaei, Partow [Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); O' Brien, Susan [Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kedir, Aziza; Said, Mustefa; Grant, Jonathan D. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Thomas, Deborah A. [Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gidley, Paul W. [Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Arzu, Isidora; Pinnix, Chelsea; Reed, Valerie [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dabaja, Bouthaina S., E-mail: bdabaja@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-12-01

    Purpose: To determine the benefit of radiation therapy (RT) in resolution of neurologic symptoms and deficits and whether the type of RT fields influences central nervous system (CNS) control in adults with CNS leukemia. Methods and Materials: A total of 163 adults from 1996 to 2012 were retrospectively analyzed. Potential associations between use of radiation and outcome were investigated by univariate and multivariate analysis. Results: The median survival time was 3.8 months after RT. Common presenting symptoms were headache in 79 patients (49%), cranial nerve VII deficit in 46 (28%), and cranial nerve II deficit in 44 (27%). RT was delivered to the base of skull in 48 patients (29%), to the whole brain (WB) in 67 (41%), and to the craniospinal axis (CS) in 48 (29%). Among 149 patients with a total of 233 deficits, resolution was observed in 34 deficits (15%), improvement in 126 deficits (54%), stability in 34 deficits (15%), and progression in 39 deficits (17%). The 12-month CNS progression-free survival was 77% among those receiving CS/WB and 51% among those receiving base of skull RT (P=.02). On multivariate analysis, patients who did not undergo stem cell transplantation after RT and base of skull RT were associated with worse CNS progression-free survival. Conclusions: Improvement or resolution of symptoms occurred in two thirds of deficits after RT. Comprehensive radiation to the WB or CS seems to offer a better outcome, especially in isolated CNS involvement.

  14. Comprehensive Craniospinal Radiation for Controlling Central Nervous System Leukemia

    International Nuclear Information System (INIS)

    Walker, Gary V.; Shihadeh, Ferial; Kantarjian, Hagop; Allen, Pamela; Rondon, Gabriela; Kebriaei, Partow; O'Brien, Susan; Kedir, Aziza; Said, Mustefa; Grant, Jonathan D.; Thomas, Deborah A.; Gidley, Paul W.; Arzu, Isidora; Pinnix, Chelsea; Reed, Valerie; Dabaja, Bouthaina S.

    2014-01-01

    Purpose: To determine the benefit of radiation therapy (RT) in resolution of neurologic symptoms and deficits and whether the type of RT fields influences central nervous system (CNS) control in adults with CNS leukemia. Methods and Materials: A total of 163 adults from 1996 to 2012 were retrospectively analyzed. Potential associations between use of radiation and outcome were investigated by univariate and multivariate analysis. Results: The median survival time was 3.8 months after RT. Common presenting symptoms were headache in 79 patients (49%), cranial nerve VII deficit in 46 (28%), and cranial nerve II deficit in 44 (27%). RT was delivered to the base of skull in 48 patients (29%), to the whole brain (WB) in 67 (41%), and to the craniospinal axis (CS) in 48 (29%). Among 149 patients with a total of 233 deficits, resolution was observed in 34 deficits (15%), improvement in 126 deficits (54%), stability in 34 deficits (15%), and progression in 39 deficits (17%). The 12-month CNS progression-free survival was 77% among those receiving CS/WB and 51% among those receiving base of skull RT (P=.02). On multivariate analysis, patients who did not undergo stem cell transplantation after RT and base of skull RT were associated with worse CNS progression-free survival. Conclusions: Improvement or resolution of symptoms occurred in two thirds of deficits after RT. Comprehensive radiation to the WB or CS seems to offer a better outcome, especially in isolated CNS involvement

  15. Simplified system for the pressure control of a Nucleo electric central of the BWR type; Sistema simplificado para el control de presion de una central Nucleoelectrica del tipo BWR

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez J, J. [FI-UNAM, DEPFI Campus Morelos, Jiutepec, Morelos (Mexico)

    2003-07-01

    One of the main preoccupations of the electric power generator stations is the appropriate operation of the same ones. The operators must be qualified to respond in an adequate way and to be able to take to these power stations to an optimal, sure and stable operation condition under any circumstance. The Laboratory of Analysis in Nuclear Reactors Engineering (LAIRN) of the Engineering Faculty of UNAM (Fl) in collaboration with the International Atomic Energy Agency (IAEA), it develops an interactive classroom simulator in which simulations of the phenomena which take place in a nuclear power station are executed. The classroom simulator bases its operation on specialized nuclear codes feeding interactive graphic unfolding with those that it is possible to make a monitoring, supervision and control of the behavior of the power station under any operation regime, either in normal operation, transitory events or postulated accident sequence. The development of this classroom simulator includes a modular and re configurable structure. Due to it is indispensable to count with a higher inter activity with the system it is included the simulation of the control system of the plant and inside the same, one of those more important it is the reactor pressure control system. The present work describes the conceptual design and the used methodology for the development and implementation in the simulator of a simplified model of the pressure control system for a BWR generic central. The reach of the development will allow to accomplish the necessary tests to demonstrate that this has an adequate performance according to the carried out simplifications. (Author)

  16. The central nervous system

    International Nuclear Information System (INIS)

    Holmes, R.A.

    1984-01-01

    The first section presents a comprehensive evaluation of radionuclide imaging of the central nervous system and provides a comparison of the detection accuracies of radionuclide imaging (RNI) and XCT in certain lesions, realizing that the XCT results may vary when radiocontrast or newer generation XCT scanners are used. Although conventional radionuclide imaging of the central nervous system has experienced no significant changes over the last 7 years except for mild refinements, a new section has been added on positron emission tomography (PET). Most positron radiopharmaceuticals passively cross the intact blood-brain barrier, and their localization has catalyzed renewed interest in our ability to metabolically study and obtain images of the central nervous system. The section on radionuclide cisternography has been rewritten to reflect present day practice and the wider application of XCT in describing conditions affecting the ventricular system

  17. Sizewell integrated system for centralized operations: getting it all together

    International Nuclear Information System (INIS)

    Cook, B.M.; Robinson, D.E.P.

    1992-01-01

    In June 1991, Westinghouse was awarded a contract by Nuclear Electric to supply the Integrated System for Centralized Operations (ISCO) for the Sizewell B nuclear power plant under construction in Suffolk. This system is a large scale distributed control and instrumentation system that will perform safety and control functions for the primary and secondary systems for the plant. Combined with the control and instrumentation equipment that was already being supplied for the plant by Westinghouse, this will be the most extensive integration of modern digital control equipment on a nuclear power plant to date. The ISCO architecture, consisting of 3 major segments -high integrity control, process control and the distributed computer system - is described. The history of the ISCO development is explained. (Author)

  18. Innate immune responses in central nervous system inflammation

    DEFF Research Database (Denmark)

    Finsen, Bente; Owens, Trevor

    2011-01-01

    In autoimmune diseases of the central nervous system (CNS), innate glial cell responses play a key role in determining the outcome of leukocyte infiltration. Access of leukocytes is controlled via complex interactions with glial components of the blood-brain barrier that include angiotensin II...

  19. Tachykinin-1 in the central nervous system regulates adiposity in rodents.

    Science.gov (United States)

    Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego

    2015-05-01

    Ghrelin is a circulating hormone that targets the central nervous system to regulate feeding and adiposity. The best-characterized neural system that mediates the effects of ghrelin on energy balance involves the activation of neuropeptide Y/agouti-related peptide neurons, expressed exclusively in the arcuate nucleus of the hypothalamus. However, ghrelin receptors are expressed in other neuronal populations involved in the control of energy balance. We combined laser capture microdissection of several nuclei of the central nervous system expressing the ghrelin receptor (GH secretagoge receptor) with microarray gene expression analysis to identify additional neuronal systems involved in the control of central nervous system-ghrelin action. We identified tachykinin-1 (Tac1) as a gene negatively regulated by ghrelin in the hypothalamus. Furthermore, we identified neuropeptide k as the TAC1-derived peptide with more prominent activity, inducing negative energy balance when delivered directly into the brain. Conversely, loss of Tac1 expression enhances the effectiveness of ghrelin promoting fat mass gain both in male and in female mice and increases the susceptibility to diet-induced obesity in ovariectomized mice. Taken together, our data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function.

  20. Central control of cardiorespiratory interactions in fish.

    Science.gov (United States)

    Taylor, Edwin W; Leite, Cleo A C; Levings, Jennifer J

    2009-01-01

    Fish control the relative flow rates of water and blood over the gills in order to optimise respiratory gas exchange. As both flows are markedly pulsatile, close beat-to-beat relationships can be predicted. Cardiorespiratory interactions in fish are controlled primarily by activity in the parasympathetic nervous system that has its origin in cardiac vagal preganglionic neurons. Recordings of efferent activity in the cardiac vagus include units firing in respiration-related bursts. Bursts of electrical stimuli delivered peripherally to the cardiac vagus or centrally to respiratory branches of cranial nerves can recruit the heart over a range of frequencies. So, phasic, efferent activity in cardiac vagi, that in the intact fish are respiration-related, can cause heart rate to be modulated by the respiratory rhythm. In elasmobranch fishes this phasic activity seems to arise primarily from central feed-forward interactions with respiratory motor neurones that have overlapping distributions with cardiac neurons in the brainstem. In teleost fish, they arise from increased levels of efferent vagal activity arising from reflex stimulation of chemoreceptors and mechanoreceptors in the orobranchial cavity. However, these differences are largely a matter of emphasis as both groups show elements of feed-forward and feed-back control of cardiorespiratory interactions.

  1. Application of human engineering to design of central control room and evaluation

    International Nuclear Information System (INIS)

    Tani, Mamoru

    1986-01-01

    The central control room of a nuclear power station is the center of the operation control, monitoring and management of the plant, therefore, the design by the application of human engineering has been performed on the basis of the experience and achievement in thermal power stations and other industries. In this report, the application of human engineering to the development of the new control boards for PWRs and the evaluation are described. In a nuclear power station, the number of the machinery and equipment composing it is large, and the interrelation among them is complex, accordingly, in the information processing system for operation monitoring and control, the man-machine interface works with high density. The concept of multiple protection design requires to show numerous plant parameters on a central control board, and this also complicates the man-machine interface. The introduction of human engineering was seriously studied after the TMI accident. In order to increase the safety and reliability of a plant, the new central control and monitoring system aims at facilitating operation and monitoring, and lightening burden and preventing mistakes in handling and judgement. The operational sequence diagram and mock-up varification, the application of human engineering and the evaluation, the synthetic real-time verification at the time of abnormality and accident, and the evaluation of the reliability improvement of men are reported. (Kako, I.)

  2. Maintenance and adjustment of control systems of central heating turbines

    International Nuclear Information System (INIS)

    Karasyuk, V.A.; Balashov, A.M.

    1994-01-01

    Principles of operation and design of systems of automatic control of steam turbines with controlled heating stem extraction are described. Specific features of maintenance and adjustment of the most common domestic turbines are considered. Recommendations on testing state of turbine control systems and improving reliability of their operation are given. 22 refs., 51 refs

  3. Toward a cross-border early-warning system for Central Asia

    Directory of Open Access Journals (Sweden)

    Jacek Stankiewicz

    2015-04-01

    Full Text Available Rapidly expanding urban areas in Central Asia are increasingly vulnerable to seismic risk; but at present, no earthquake early warning (EEW systems exist in the region despite their successful implementation in other earthquake-prone areas. Such systems aim to provide short (seconds to tens of seconds warnings of impending disaster, enabling the first risk mitigation and damage control steps to be taken. This study presents the feasibility of a large scale cross-border regional system for Central Asian countries. Genetic algorithms are used to design efficient EEW networks, computing optimal station locations and trigger thresholds in recorded ground acceleration. Installation of such systems within 3 years aims to both reducing the endemic lack of strong motion data in Central Asia that is limiting the possibility of improving seismic hazard assessment, and at providing the first regional earthquake early warning system in the area.

  4. Microgrid central controller development and hierarchical control implemetation in the intelligent microgrid lab of Aalborg University

    OpenAIRE

    Meng, Lexuan; Savaghebi, Mehdi; Andrade, Fabio; Vasquez Quintero, Juan Carlos; Guerrero, Josep M.; Graells Sobré, Moisès

    2015-01-01

    This paper presents the development of a microgrid central controller in an inverter-based intelligent microgrid (iMG) lab in Aalborg University, Denmark. The iMG lab aims to provide a flexible experimental platform for comprehensive studies of microgrids. The complete control system applied in this lab is based on the hierarchical control scheme for microgrids and includes primary, secondary and tertiary control. The structure of the lab, including the lab facilities, configurations and comm...

  5. The Epicure Control System

    International Nuclear Information System (INIS)

    Dambik, E.; Kline, D.; West, R.

    1993-09-01

    The Epicure Control System supports the Fermilab fixed target physics program. The system is distributed across a network of many different types of components. The use of multiple layers on interfaces for communication between logical tasks fits the client-server model. Physical devices are read and controlled using symbolic references entered into a database with an editor utility. The database system consists of a central portion containing all device information and optimized portions distributed among many nodes. Updates to the database are available throughout the system within minutes after being requested

  6. PLCs for nuclear fire control system

    International Nuclear Information System (INIS)

    McArthur, Neil

    1990-01-01

    The new Thermal Oxide Reprocessing Plant (THORP) at British Nuclear Fuel's Sellafield site is a very large and complex system. This article describes the computerized control system used for fire damage control in the two main production areas, the head end and the chemical separation segments. Over one thousand fire dampers are controlled by an interlinking system of small computers linked to a main system in the central control room. The choice of hardware and software is also described. (UK)

  7. Heating networks and domestic central heating systems

    Energy Technology Data Exchange (ETDEWEB)

    Kamler, W; Wasilewski, W

    1976-08-01

    This is a comprehensive survey of the 26 contributions from 8 European countries submitted to the 3rd International District Heating Conference in Warsaw held on the subject 'Heating Networks and Domestic Central Heating Systems'. The contributions are grouped according to 8 groups of subjects: (1) heat carriers and their parameters; (2) system of heating networks; (3) calculation and optimization of heating networks; (4) construction of heating networks; (5) operation control and automation; (6) operational problems; (7) corrosion problems; and (8) methods of heat accounting.

  8. Nova control system: goals, architecture, and system design

    International Nuclear Information System (INIS)

    Suski, G.J.; Duffy, J.M.; Gritton, D.G.; Holloway, F.W.; Krammen, J.R.; Ozarski, R.G.; Severyn, J.R.; Van Arsdall, P.J.

    1982-01-01

    The control system for the Nova laser must operate reliably in a harsh pulse power environment and satisfy requirements of technical functionality, flexibility, maintainability and operability. It is composed of four fundamental subsystems: Power Conditioning, Alignment, Laser Diagnostics, and Target Diagnostics, together with a fifth, unifying subsystem called Central Controls. The system architecture utilizes a collection of distributed microcomputers, minicomputers, and components interconnected through high speed fiber optic communications systems. The design objectives, development strategy and architecture of the overall control system and each of its four fundamental subsystems are discussed. Specific hardware and software developments in several areas are also covered

  9. Entry control system for large populations

    International Nuclear Information System (INIS)

    Merillat, P.D.

    1982-01-01

    An Entry Control System has been developed which is appropriate for use at an installation with a large population requiring access over a large area. This is accomplished by centralizing the data base management and enrollment functions and decentralizing the guard-assisted, positive personnel identification and access functions. Current information pertaining to all enrollees is maintained through user-friendly enrollment stations. These stations may be used to enroll individuals, alter their area access authorizations, change expiration dates, and other similar functions. An audit trail of data base alterations is provided to the System Manager. Decentrailized systems exist at each area to which access is controlled. The central system provides these systems with the necessary entry control information to allow them to operate microprocessor-driven entry control devices. The system is comprised of commercially available entry control components and is structured such that it will be able to incorporate improved devices as technology porogresses. Currently, access is granted to individuals who possess a valid credential, have current access authorization, can supply a memorized personal identification number, and whose physical hand dimensions match their profile obtained during enrollment. The entry control devices report misuses as security violations to a Guard Alarm Display and Assessment System

  10. The memory systems of children with (central) auditory disorder.

    Science.gov (United States)

    Pires, Mayra Monteiro; Mota, Mailce Borges; Pinheiro, Maria Madalena Canina

    2015-01-01

    This study aims to investigate working, declarative, and procedural memory in children with (central) auditory processing disorder who showed poor phonological awareness. Thirty 9- and 10-year-old children participated in the study and were distributed into two groups: a control group consisting of 15 children with typical development, and an experimental group consisting of 15 children with (central) auditory processing disorder who were classified according to three behavioral tests and who showed poor phonological awareness in the CONFIAS test battery. The memory systems were assessed through the adapted tests in the program E-PRIME 2.0. The working memory was assessed by the Working Memory Test Battery for Children (WMTB-C), whereas the declarative memory was assessed by a picture-naming test and the procedural memory was assessed by means of a morphosyntactic processing test. The results showed that, when compared to the control group, children with poor phonological awareness scored lower in the working, declarative, and procedural memory tasks. The results of this study suggest that in children with (central) auditory processing disorder, phonological awareness is associated with the analyzed memory systems.

  11. Contamination Control: a systems approach

    NARCIS (Netherlands)

    Donck, J.C.J. van der

    2010-01-01

    Contamination influences a wide variety of industrial processes. For complex systems, contamination control, the collective effort to control contamination to such a level that it guarantees or even improves process or product functionality, offers a way for finding workable solutions. Central in

  12. Final report on the FMIT Control System

    International Nuclear Information System (INIS)

    Johnson, J.A.

    1985-01-01

    The computer control system for the Fusion Materials Irradiation Test Facility (FMIT) prototype accelerator was designed using distributed intelligence driven by a distributed database. The system consists of two minicomputers in the central control room and four microcomputers residing in CAMAC crates located near appropriate subsystems of the accelerator. The system uses single vendor hardware as much as practical in an attempt to minimize the maintenance problems. Local control consoles are an integral part of each node computer to provide subsystem check-out. The main console is located in the central control room and permits one-point operation of the complete control system. Automatic surveillance is provided for each data channel by the node computer with out-of-bounds alarms sent to the main console. Report by exception is used for data logging. This control system has been operational for two years. The computers are too heavily loaded and the operator response is slower than desired. A system upgrade to a faster local-area network has been undertaken and is scheduled to be operational by conference time

  13. FY 1999 report on the results of the experimental verification on the establishment of a centralized load control system. Study of an advanced centralized load control system, etc.; 1999 nendo fuka shuchu seigyo system kakuritsu jissho shikehn kodo fuka shuchu seigyo system nado no kenkyu. Fuka shuchu seigyo system kakuritsu jissho shiken

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The paper described the FY 1999 results of the experimental verification on a centralized load control system for the residential electric power demand. The air conditioning control is effective for load leveling, and for it, it is important to infiltrate the consciousness of energy saving into people. Users are not very interested in the information on power rates, would rather tend to seek comfortableness, and are less conscious of energy saving on days of unusual summer heat. Further, the power control in peal time zone was made by indicating users the actual state of power use by a combination of the two-way communication and the automatic meter reading system. However, at present, it cannot be denied that the power rate is higher even in indirect load control equipment with necessary/minimum conditions than the existing power source. It is a must to reduce the cost. The liberalization of electric power is progressing fast, and incentives for DSM are decreasing, but each of advanced countries is getting sensitive to the obedience to COP3. In addition to DSM such as the rebate program and financing program by the existing surcharge system, they are making efforts for development/promotion of new energy by creating the green electric power market. The load control technology is expected which does not disturb comfortableness and amenity of users. (NEDO)

  14. Fanconi anemia: correlating central nervous system malformations and genetic complementation groups

    International Nuclear Information System (INIS)

    Johnson-Tesch, Benjamin A.; Gawande, Rakhee S.; Nascene, David R.; Zhang, Lei; MacMillan, Margaret L.

    2017-01-01

    Congenital central nervous system abnormalities in children with Fanconi anemia are poorly characterized, especially with regard to specific genetic complementation groups. To characterize the impact of genetic complementation groups on central nervous system anatomy. Through chart review we identified 36 patients with Fanconi anemia with available brain MRIs at the University of Minnesota (average age, 11.3 years; range, 1-43 years; M:F=19:17), which we reviewed and compared to 19 age- and sex-matched controls (average age, 7.9 years; range, 2-18 years; M:F=9:10). Genotypic information was available for 27 patients (15 FA-A, 2 FA-C, 3 FA-G, and 7 FA-D1 [biallelic mutations in BRCA2 gene]). Of the 36 patients, 61% had at least one congenital central nervous system or skull base abnormality. These included hypoplastic clivus (n=12), hypoplastic adenohypophysis (n=11), platybasia (n=8), pontocerebellar hypoplasia (n=7), isolated pontine hypoplasia (n=4), isolated vermis hypoplasia (n=3), and ectopic neurohypophysis (n=6). Average pituitary volume was significantly less in patients with Fanconi anemia (P<0.0001) than in controls. Basal angle was significantly greater in Fanconi anemia patients (P=0.006), but the basal angle of those with FA-D1 was not significantly different from controls (P=0.239). Clivus length was less in the Fanconi anemia group (P=0.002), but significance was only observed in the FA-D1 subgroup (P<0.0001). Of the seven patients meeting criteria for pontocerebellar hypoplasia, six belonged to the FA-D1 group. Patients with Fanconi anemia have higher incidences of ectopic neurohypophysis, adenohypophysis hypoplasia, platybasia and other midline central nervous system skull base posterior fossa abnormalities than age- and sex-matched controls. Patients with posterior fossa abnormalities, including pontocerebellar hypoplasia, are more likely to have biallelic BRCA2 mutations. (orig.)

  15. Fanconi anemia: correlating central nervous system malformations and genetic complementation groups

    Energy Technology Data Exchange (ETDEWEB)

    Johnson-Tesch, Benjamin A. [University of Minnesota, Department of Radiology, Minneapolis, MN (United States); Gawande, Rakhee S.; Nascene, David R. [University of Minnesota, Department of Radiology, Neuroradiology Section, Minneapolis, MN (United States); Zhang, Lei [University of Minnesota, Biostatistical Design and Analysis Centre, Minneapolis, MN (United States); MacMillan, Margaret L. [University of Minnesota, Blood and Marrow Transplant Program, Department of Pediatrics, Minneapolis, MN (United States)

    2017-06-15

    Congenital central nervous system abnormalities in children with Fanconi anemia are poorly characterized, especially with regard to specific genetic complementation groups. To characterize the impact of genetic complementation groups on central nervous system anatomy. Through chart review we identified 36 patients with Fanconi anemia with available brain MRIs at the University of Minnesota (average age, 11.3 years; range, 1-43 years; M:F=19:17), which we reviewed and compared to 19 age- and sex-matched controls (average age, 7.9 years; range, 2-18 years; M:F=9:10). Genotypic information was available for 27 patients (15 FA-A, 2 FA-C, 3 FA-G, and 7 FA-D1 [biallelic mutations in BRCA2 gene]). Of the 36 patients, 61% had at least one congenital central nervous system or skull base abnormality. These included hypoplastic clivus (n=12), hypoplastic adenohypophysis (n=11), platybasia (n=8), pontocerebellar hypoplasia (n=7), isolated pontine hypoplasia (n=4), isolated vermis hypoplasia (n=3), and ectopic neurohypophysis (n=6). Average pituitary volume was significantly less in patients with Fanconi anemia (P<0.0001) than in controls. Basal angle was significantly greater in Fanconi anemia patients (P=0.006), but the basal angle of those with FA-D1 was not significantly different from controls (P=0.239). Clivus length was less in the Fanconi anemia group (P=0.002), but significance was only observed in the FA-D1 subgroup (P<0.0001). Of the seven patients meeting criteria for pontocerebellar hypoplasia, six belonged to the FA-D1 group. Patients with Fanconi anemia have higher incidences of ectopic neurohypophysis, adenohypophysis hypoplasia, platybasia and other midline central nervous system skull base posterior fossa abnormalities than age- and sex-matched controls. Patients with posterior fossa abnormalities, including pontocerebellar hypoplasia, are more likely to have biallelic BRCA2 mutations. (orig.)

  16. Fuel fabrication instrumentation and control system overview

    International Nuclear Information System (INIS)

    Bennett, D.W.; Fritz, R.L.

    1980-10-01

    A process instrumentation and control system is being developed for automated fabrication of breeder reactor fuel at the Hanford Engineering Development Laboratory (HEDL) in Richland, Washington. The basic elements of the control system are a centralized computer system linked to distributed local computers, which direct individual process applications. The control philosophy developed for the equipment automation program stresses system flexibility and inherent levels of redundant control capabilities. Four different control points have been developed for each unit process operation

  17. Fanconi anemia: correlating central nervous system malformations and genetic complementation groups.

    Science.gov (United States)

    Johnson-Tesch, Benjamin A; Gawande, Rakhee S; Zhang, Lei; MacMillan, Margaret L; Nascene, David R

    2017-06-01

    Congenital central nervous system abnormalities in children with Fanconi anemia are poorly characterized, especially with regard to specific genetic complementation groups. To characterize the impact of genetic complementation groups on central nervous system anatomy. Through chart review we identified 36 patients with Fanconi anemia with available brain MRIs at the University of Minnesota (average age, 11.3 years; range, 1-43 years; M:F=19:17), which we reviewed and compared to 19 age- and sex-matched controls (average age, 7.9 years; range, 2-18 years; M:F=9:10). Genotypic information was available for 27 patients (15 FA-A, 2 FA-C, 3 FA-G, and 7 FA-D1 [biallelic mutations in BRCA2 gene]). Of the 36 patients, 61% had at least one congenital central nervous system or skull base abnormality. These included hypoplastic clivus (n=12), hypoplastic adenohypophysis (n=11), platybasia (n=8), pontocerebellar hypoplasia (n=7), isolated pontine hypoplasia (n=4), isolated vermis hypoplasia (n=3), and ectopic neurohypophysis (n=6). Average pituitary volume was significantly less in patients with Fanconi anemia (PFanconi anemia patients (P=0.006), but the basal angle of those with FA-D1 was not significantly different from controls (P=0.239). Clivus length was less in the Fanconi anemia group (P=0.002), but significance was only observed in the FA-D1 subgroup (PFanconi anemia have higher incidences of ectopic neurohypophysis, adenohypophysis hypoplasia, platybasia and other midline central nervous system skull base posterior fossa abnormalities than age- and sex-matched controls. Patients with posterior fossa abnormalities, including pontocerebellar hypoplasia, are more likely to have biallelic BRCA2 mutations.

  18. Central Control of Heat Pump for Smart Grid Purposes Tested on Single Family Houses

    DEFF Research Database (Denmark)

    Pedersen, Tom S.; Andersen, Palle; Nielsen, Kirsten M.

    2013-01-01

    A challenge in Denmark in the near future is to balance the electrical grid due to a large increase in the renewable energy production mainly from wind turbines. In this work a central control system using heat pumps in single family houses to help balancing the grid is investigated. The central...

  19. Distributed Secondary Control for Islanded MicroGrids – A Networked Control Systems Approach

    DEFF Research Database (Denmark)

    Shafiee, Qobad; Vasquez, Juan Carlos; Guerrero, Josep M.

    2012-01-01

    This paper presents a novel approach to conceive the secondary control in droop-controlled MicroGrids. The conventional approach is based on restoring the frequency and amplitude deviations produced by the local droop controllers by using a MicroGrid Central Controller. A distributed networked...... control system is used in order to implement a distributed secondary control thus avoiding the use of a MicroGrid Central Control. The proposed approach is not only able to restore frequency and voltage of the MicroGrid but also ensures reactive power sharing. The distributed secondary control do...

  20. Piping information centralized management system for nuclear plant, PIMAS

    International Nuclear Information System (INIS)

    Matsumoto, Masaru

    1977-01-01

    Piping works frequently cause many troubles in the progress of construction works, because piping is the final procedure in design and construction and is forced to suffer the problems in earlier stages. The enormous amount of data on quality control and management leads to the employment of many unskilled designers of low technical ability, and it causes confusion in installation and inspection works. In order to improve the situation, the ''piping information management system for nuclear plants (PIMAS)'' has been introduced attempting labor-saving and speed-up. Its main purposes are the mechanization of drafting works, the centralization of piping informations, labor-saving and speed-up in preparing production control data and material management. The features of the system are as follows: anyone can use the same informations whenever he requires them because the informations handled in design works are contained in a large computer; the system can be operated on-line, and the terminals are provided in the sections which require informations; and the sub-systems are completed for preparing a variety of drawings and data. Through the system, material control has become possible by using the material data in each plant, stock material data and the information on the revision of drawings in the design department. Efficiency improvement and information centralization in the manufacturing department have also been achieved because the computer has prepared many kinds of slips based on unified drawings and accurate informations. (Wakatsuki, Y.)

  1. Simulation Research on an Electric Vehicle Chassis System Based on a Collaborative Control System

    Directory of Open Access Journals (Sweden)

    Nenglian Feng

    2013-01-01

    Full Text Available This paper presents a collaborative control system for an electric vehicle chassis based on a centralized and hierarchical control architecture. The centralized controller was designed for the suspension and steering system, which is used for improving ride comfort and handling stability; the hierarchical controller was designed for the braking system, which is used for distributing the proportion of hydraulic braking and regenerative braking to improve braking performance. These two sub-controllers function at the same level of the vehicle chassis control system. In order to reduce the potential conflict between the two sub-controllers and realize a coordination optimization of electric vehicle performance, a collaborative controller was built, which serves as the upper controller to carry out an overall coordination analysis according to vehicle signals and revises the decisions of sub-controllers. A simulation experiment was carried out with the MATLAB/Simulink software. The simulation results show that the proposed collaborative control system can achieve an optimized vehicle handling stability and braking safety.

  2. Exporting Variables in a Hierarchically Distributed Control System

    Energy Technology Data Exchange (ETDEWEB)

    Chamizo Llatas, M

    1995-07-01

    We describe the Remote Variable Access Service (RVAS), a network service developed and used in the distributed control and monitoring system of the TJ-II Heliac, which is under construction at CIEMAT (Madrid, Spain) and devoted to plasma studies in the nuclear fusion field. The architecture of the TJ-II control system consists of one central Sun workstation Sparc 10 and several autonomous subsystems based on VME crates with embedded processors running the OS-9 (V.24) real time operating system. The RVAS service allows state variables in local control processes running in subsystems to be exported to remote processes running in the central control workstation. Thus we extend the concept of exporting of file systems in UNIX machines to variables in processes running in different machines. (Author) 6 refs.

  3. Exporting Variables in a Hierarchically Distributed Control System

    International Nuclear Information System (INIS)

    Diaz Martin; Martinez Laso, L.

    1995-01-01

    We describe the Remote Variable Access Service (RVAS), a network service developed and use in the distributed control and monitoring system of the TJ-II Heliac, which is under construction at CIEMAT (Madrid, Spain) and devoted to plasma studies in the nuclear fusion field. The architecture of the TJ-II control system consists of one central Sun workstation Sparc 10 and several autonomous subsystems based on VME crates with embedded processors running the os-9 (V.24) real time operating system. The RVAS service allows state variables in local control processes running in subsystems to be exported to remote processes running in the central control workstation. Thus we extend the concept of exporting of file systems in UNIX machines to variables in processes running in different machines. (Author)

  4. Exporting Variables in a Hierarchically Distributed Control System

    International Nuclear Information System (INIS)

    Chamizo Llatas, M.

    1995-01-01

    We describe the Remote Variable Access Service (RVAS), a network service developed and used in the distributed control and monitoring system of the TJ-II Heliac, which is under construction at CIEMAT (Madrid, Spain) and devoted to plasma studies in the nuclear fusion field. The architecture of the TJ-II control system consists of one central Sun workstation Sparc 10 and several autonomous subsystems based on VME crates with embedded processors running the OS-9 (V.24) real time operating system. The RVAS service allows state variables in local control processes running in subsystems to be exported to remote processes running in the central control workstation. Thus we extend the concept of exporting of file systems in UNIX machines to variables in processes running in different machines. (Author) 6 refs

  5. Design, implementation and evalution of a central unit for controlling climatic conditions in the greenhouse

    OpenAIRE

    Gh. Zarei; A. Azizi

    2016-01-01

    In greenhouse culture, in addition to increasing the quantity and quality of crop production in comparison with traditional methods, the agricultural inputs are saved, too. Recently, using new methods, designs and materials, and higher automation in greenhouses, better management has become possible for enhancing yield and improving the quality of greenhouse crops. The constructed and evaluated central controller unit (CCU) is a central controller system and computerized monitoring unit for g...

  6. Active Power Dispatch Method for a Wind Farm Central Controller Considering Wake Effect

    DEFF Research Database (Denmark)

    Tian, Jie; Su, Chi; N. Soltani, Mohsen

    2014-01-01

    With the increasing integration of the wind power into the power system, wind farm are required to be controlled as a single unit and have all the same control tasks as conventional power plants. The wind farm central controller receives control orders from Transmission System Operator (TSO), the...... Optimization (PSO) is used to obtain the optimal wind power for each wind turbine. A case study is carried out. The available wind power of the wind farm was compared between the traditional dispatch method and the proposed dispatch method with the consideration of the wake effect....

  7. Energy evaluation of optimal control strategies for central VWV chiller systems

    International Nuclear Information System (INIS)

    Jin Xinqiao; Du Zhimin; Xiao Xiaokun

    2007-01-01

    Under various conditions, the actual load of the heating, ventilation and air conditioning (HVAC) systems is less than it is originally designed in most operation periods. To save energy and to optimize the controls for chilling systems, the performance of variable water volume (VWV) systems and characteristics of control systems are analyzed, and three strategies are presented and tested based on simulation in this paper. Energy evaluation for the three strategies shows that they can save energy to some extent, and there is potential remained. To minimize the energy consumption of chilling system, the setpoints of controls of supply chilled water temperature and supply head of secondary pump should be optimized simultaneously

  8. The Design and Comparison of Central and Distributed Light Sensored Smart LED Lighting Systems

    Directory of Open Access Journals (Sweden)

    Mehmet Ali Özçelik

    2018-01-01

    Full Text Available There is a lack of published peer-reviewed research comparing the efficiencies of distributed versus central sensor-controlled LED lighting systems. This research proposes improving the smart illumination of a room with external fenestration using central and distributed light sensors. The optical and electrical measurements of the daylight have been made in the case where the light was not distributed evenly and not sufficient. Test results show that the proposed distributed light sensor illumination system has increased the efficiency by 28% when compared to the proposed central system. It has also been shown that the two tested systems are more cost-effective than common smart illumination systems.

  9. The Central Nervous System Sites Mediating the Orexigenic Actions of Ghrelin

    Science.gov (United States)

    Mason, B.L.; Wang, Q.; Zigman, J.M.

    2014-01-01

    The peptide hormone ghrelin is important for both homeostatic and hedonic eating behaviors, and its orexigenic actions occur mainly via binding to the only known ghrelin receptor, the growth hormone secretagogue receptor (GHSR). GHSRs are located in several distinct regions of the central nervous system. This review discusses those central nervous system sites that have been found to play critical roles in the orexigenic actions of ghrelin, including hypothalamic nuclei, the hippocampus, the amygdala, the caudal brain stem, and midbrain dopaminergic neurons. Hopefully, this review can be used as a stepping stone for the reader wanting to gain a clearer understanding of the central nervous system sites of direct ghrelin action on feeding behavior, and as inspiration for future studies to provide an even-more-detailed map of the neurocircuitry controlling eating and body weight. PMID:24111557

  10. Underground ventilation remote monitoring and control system

    International Nuclear Information System (INIS)

    Strever, M.T.; Wallace, K.G. Jr.; McDaniel, K.H.

    1995-01-01

    This paper presents the design and installation of an underground ventilation remote monitoring and control system at the Waste Isolation Pilot Plant. This facility is designed to demonstrate safe underground disposal of U.S. defense generated transuranic nuclear waste. To improve the operability of the ventilation system, an underground remote monitoring and control system was designed and installed. The system consists of 15 air velocity sensors and 8 differential pressure sensors strategically located throughout the underground facility providing real-time data regarding the status of the ventilation system. In addition, a control system was installed on the main underground air regulators. The regulator control system gives indication of the regulator position and can be controlled either locally or remotely. The sensor output is displayed locally and at a central surface location through the site-wide Central Monitoring System (CMS). The CMS operator can review all sensor data and can remotely operate the main underground regulators. Furthermore, the Virtual Address Extension (VAX) network allows the ventilation engineer to retrieve real-time ventilation data on his personal computer located in his workstation. This paper describes the types of sensors selected, the installation of the instrumentation, and the initial operation of the remote monitoring system

  11. Solar central receiver hybrid power system. Phase I study

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-11-01

    A management plan is presented for implementation during the Solar Central Receiver Hybrid Power System - Phase I study project. The project plan and the management controls that will be used to assure technically adequate, timely and cost effective performance of the work required to prepare the designated end products are described. Bechtel in-house controls and those to be used in directing the subcontractors are described. Phase I of the project consists of tradeoff studies, parametric analyses, and engineering studies leading to conceptual definition and evaluation of a commercial hybrid power system that has the potential for supplying economically competitive electric power to a utility grid in the 1985-1990 time frame. The scope also includes the preparation of a development plan for the resolution of technical uncertainties and the preparation of plans and a proposal for Phase II of the program. The technical approach will be based on a central receiver solar energy collection scheme which supplies thermal energy to a combined cycle, generating system, consisting of a gas turbine cycle combined with a steam bottoming cycle by means of a heat recovery steam generator.

  12. The Ganil computer control system renewal

    International Nuclear Information System (INIS)

    David, L.; Lecorche, E.; Luong, T.T.; Ulrich, M.

    1990-01-01

    Since 1982 the GANIL heavy ion accelerator has been under the control of 16-bit minicomputers MITRA, programmable logic controllers and microprocessorized Camac controllers, structured into a partially centralized system. This control system has to be renewed to meet the increasing demands of the accelerator operation which aims to provide higher quality ion beams under more reliable conditions. This paper gives a brief description of the existing control system and then discusses the main issues of the design and the implementation of the future control system: distributed powerful processors federated through Ethernet and flexible network-wide database access, VME standard and front-end microprocessors, enhanced color graphic tools and workstation based operator interface

  13. Centralized coordinated control to protect the JET ITER-like wall

    International Nuclear Information System (INIS)

    Stephen, A.V.; Arnoux, G.; Budd, T.; Card, P.; Felton, R.; Goodyear, A.; Harling, J.; Kinna, D.; Lomas, P.; McCullen, P.; Thomas, P.; Young, I.; Zastrow, K.D.; Neto, A.; Alves, D.; Valcarcel, D.F.; Jachmich, S.; Devaux, S.

    2012-01-01

    The JET ITER-like wall project (ILW) replaces the first wall carbon fibre composite tiles with beryllium and tungsten tiles which should have improved fuel retention characteristics but are less thermally robust. An enhanced protection system using new control and diagnostic systems has been designed which can modify the pre-planned experimental control to protect the new wall. Key design challenges were to extend the Level-1 supervisory control system to allow configurable responses to thermal problems to be defined without introducing excessive complexity, and to integrate the new functionality with existing control and protection systems efficiently and reliably. Alarms are generated by the vessel thermal map (VTM) system if infra-red camera measurements of tile temperatures are too high and by the plasma wall load system (WALLS) if component power limits are exceeded. The design introduces two new concepts: local protection, which inhibits individual heating components but allows the discharge to proceed, and stop responses, which allow highly configurable early termination of the pulse in the safest way for the plasma conditions and type of alarm. These are implemented via the new real-time protection system (RTPS), a centralized controller which responds to the VTM and WALLS alarms by providing override commands to the plasma shape, current, density and heating controllers. This paper describes the design and implementation of the RTPS system which is built with the Multi-threaded Application Real-Time executor (MARTe) and will present results from initial operations. (authors)

  14. Network aspects of the Fermilab control system

    International Nuclear Information System (INIS)

    Barton, H.R. Jr.

    1977-01-01

    The control system of the Fermi National Accelerator is a heavily computerized network of distributed processors. One part of the control system includes a multidrop network of eleven Lockheed MAC-16 processors, a Digital Equipment Corporation PDP-11 computer, a Xerox 530, and a Control Data 6600 system. These computers exchange information using serial hardware and dedicated cable buses. The individual functions of the central processing units in this network, the message protocols for computer communications, and design guidelines for future distributed processing control systems are discussed

  15. Software management of the LHC Detector Control Systems

    CERN Document Server

    Varela, F

    2007-01-01

    The control systems of each of the four Large Hadron Collider (LHC) experiments will contain of the order of 150 computers running the back-end applications. These applications will have to be maintained and eventually upgraded during the lifetime of the experiments, ~20 years. This paper presents the centralized software management strategy adopted by the Joint COntrols Project (JCOP) [1], which is based on a central database that holds the overall system configuration. The approach facilitates the integration of different parts of a control system and provides versioning of its various software components. The information stored in the configuration database can eventually be used to restore a computer in the event of failure.

  16. Software management of the LHC detector control systems

    CERN Document Server

    Varela, F

    2007-01-01

    The control systems of each of the four Large Hadron Collider (LHC) experiments will contain of the order of 150 computers running the back-end applications. These applications will have to be maintained and eventually upgraded during the lifetime of the experiments, ~20 years. This paper presents the centralized software management strategy adopted by the Joint COntrols Project (JCOP) [1], which is based on a central database that holds the overall system configuration. The approach facilitates the integration of different parts of a control system and provides versioning of its various software components. The information stored in the configuration database can eventually be used to restore a computer in the event of failure.

  17. 40 CFR 81.95 - Central Florida Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Quality Control Regions § 81.95 Central Florida Intrastate Air Quality Control Region. The Central Florida Intrastate Air Quality Control Region consists of the territorial area encompassed by the boundaries of the... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central Florida Intrastate Air Quality...

  18. Fuel cycle facility control system for the Integral Fast Reactor Program

    International Nuclear Information System (INIS)

    Benedict, R.W.; Tate, D.A.

    1993-01-01

    As part of the Integral Fast Reactor (IFR) Fuel Demonstration, a new distributed control system designed, implemented and installed. The Fuel processes are a combination of chemical and machining processes operated remotely. To meet this special requirement, the new control system provides complete sequential logic control motion and positioning control and continuous PID loop control. Also, a centralized computer system provides near-real time nuclear material tracking, product quality control data archiving and a centralized reporting function. The control system was configured to use programmable logic controllers, small logic controllers, personal computers with touch screens, engineering work stations and interconnecting networks. By following a structured software development method the operator interface was standardized. The system has been installed and is presently being tested for operations

  19. Implementation of time synchronized cryogenics control system network architecture for SST-1

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Rakesh J., E-mail: rpatel@ipr.res.in; Mahesuria, Gaurang; Panchal, Pradip; Panchal, Rohit; Sonara, Dasarath; Tanna, Vipul; Pradhan, Subrata

    2016-11-15

    Highlights: • SST-1 cryogenics sub-systems are 1.3 kW HRL, LN2 distribution system, current feeders system and 80 K booster system. • GUI developed in SCADA and control program developed in PLC for automation of the above sub-systems. • Implemented the cryogenics control system network to communicate all systems to InSQL server. • InSQL server configured for real time centralized process data acquisition from all connected sub-systems control nodes. • Acquired the process parameters coming from different systems at same time stamp. - Abstract: Under the SST-1 mission mandate, the several cryogenic sub-systems have been developed, upgraded and procured in prior to the SST-1 operation. New developments include 80 K Bubble type thermal shields, LN2 distribution system, LN2 booster system and current feeders system (CFS).Graphical User Interface (GUI) program developed in Wonderware SCADA and control logic program developed in Schneider make PLC for the above sub-systems. Industrial SQL server (InSQL) configured for centralized storage of real time process data coming from various control nodes of cryogenics sub-systems. The cryogenics control system network for communicating all cryogenics sub-system control nodes to InSQL server for centralized data storage and time synchronization among cryogenic sub-systems with centralized InSQL server is successfully implemented. Due to implemented time synchronization among sub-systems control nodes, it is possible to analyze the process parameters coming from different sub-systems at same time stamp. This paper describes the overview of implemented cryogenics control system network architecture for real time cryogenic process data monitor, storage and retrieval.

  20. Implementation of time synchronized cryogenics control system network architecture for SST-1

    International Nuclear Information System (INIS)

    Patel, Rakesh J.; Mahesuria, Gaurang; Panchal, Pradip; Panchal, Rohit; Sonara, Dasarath; Tanna, Vipul; Pradhan, Subrata

    2016-01-01

    Highlights: • SST-1 cryogenics sub-systems are 1.3 kW HRL, LN2 distribution system, current feeders system and 80 K booster system. • GUI developed in SCADA and control program developed in PLC for automation of the above sub-systems. • Implemented the cryogenics control system network to communicate all systems to InSQL server. • InSQL server configured for real time centralized process data acquisition from all connected sub-systems control nodes. • Acquired the process parameters coming from different systems at same time stamp. - Abstract: Under the SST-1 mission mandate, the several cryogenic sub-systems have been developed, upgraded and procured in prior to the SST-1 operation. New developments include 80 K Bubble type thermal shields, LN2 distribution system, LN2 booster system and current feeders system (CFS).Graphical User Interface (GUI) program developed in Wonderware SCADA and control logic program developed in Schneider make PLC for the above sub-systems. Industrial SQL server (InSQL) configured for centralized storage of real time process data coming from various control nodes of cryogenics sub-systems. The cryogenics control system network for communicating all cryogenics sub-system control nodes to InSQL server for centralized data storage and time synchronization among cryogenic sub-systems with centralized InSQL server is successfully implemented. Due to implemented time synchronization among sub-systems control nodes, it is possible to analyze the process parameters coming from different sub-systems at same time stamp. This paper describes the overview of implemented cryogenics control system network architecture for real time cryogenic process data monitor, storage and retrieval.

  1. Challenges to Providing a Successful Central Configuration Service to Support CERN’s New Controls Diagnostics and Monitoring System

    CERN Document Server

    Makonnen, Z; Zaharieva, Z

    2014-01-01

    The Controls Diagnostic and Monitoring service (DIAMON) provides monitoring and diagnostics tools to the operators in the CERN Control Centre. A recent reengineering presented the opportunity to restructure its data management and to integrate it with the central Controls Configuration Service (CCS). The CCS provides the Configuration Management for the Controls System for all accelerators at CERN. The new facility had to cater for the configuration management of all agents monitored by DIAMON, (>3000 computers of different types), provide deployment information, relations between metrics, and historical information. In addition, it had to be integrated into the operational CCS, while ensuring stability and data coherency. An important design decision was to largely reuse the existing infrastructure in the CCS and adapt the DIAMON data management to it e.g. by using the device/property model through a Virtual Devices framework to model the DIAMON agents. This article will show how these challenging requiremen...

  2. Manufacturing of central control system of 'JT-60' a plasma feasibility experiment device

    International Nuclear Information System (INIS)

    Kondo, Ikuo; Kimura, Toyoaki; Murai, Katsuji; Iba, Daizo; Takemaru, Koichi.

    1984-01-01

    For constructing a critical-plasma-experiment apparatus JT-60, it was necessary to develop a new control system which enables to operate safely and smoothly a large scale nuclear fusion apparatus and to carry out efficient experiment. For the purpose, the total system control facility composed of such controllers as CAMAC system, timing system and protective interlock panel with multi-computer system as the core was developed. This system generalizes, keeps watch on and controls the total facilities as the key point of the control system of JT-60, and allows flexible operation control corresponding to the diversified experimental projects. At the same time, it carries out the fast real-time control of high temperature, high density plasma. In this paper, the system constitution, function and the main contents of development of the total system control facility are reported. JT-60 is constructed to attain the critical plasma condition as the premise of nuclear fusion reactors and to scientifically verify controlled nuclear fusion. Plasma expe riment will be started in April, 1985. The real-time control of plasma for carrying out high beta operation is planned, intending to develop future economical practical reactors. (Kako, I.)

  3. Control of gaseous emissions in central Costanera S.A. of Argentina; Control de emisiones gaseosas en central Costanera S. A. de Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Brabenec, Edgardo [Unidad de Negocios Central Costanera, S. A., (Argentina)

    1997-12-31

    A description is presented of the equipment utilized at the Central Costanera, S.A. of Argentina, the requirements and the Environmental Management established for this Power Station, and the Standards and the resolutions and law instruments on Environmental issues. Also it is presented the Environmental Management plan of the Ente Nacional Regulador de Electricidad of Argentina as well as the controls and environmental corrective actions implemented at the Central Costanera, S.A. [Espanol] Se presenta una descripcion del equipo utilizado en la Central Costanera S.A. de Argentina, los requerimientos de gestion ambiental establecidos para esta central y las normas, resoluciones e instrumentos juridicos en materia ambiental. Se presenta ademas el plan de gestion ambiental del Ente Nacional Regulador de la Electricidad de Argentina asi como los controles y acciones correctivas ambientales implantadas en la Central Costanera S. A.

  4. Control of gaseous emissions in central Costanera S.A. of Argentina; Control de emisiones gaseosas en central Costanera S. A. de Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Brabenec, Edgardo [Unidad de Negocios Central Costanera, S. A., (Argentina)

    1996-12-31

    A description is presented of the equipment utilized at the Central Costanera, S.A. of Argentina, the requirements and the Environmental Management established for this Power Station, and the Standards and the resolutions and law instruments on Environmental issues. Also it is presented the Environmental Management plan of the Ente Nacional Regulador de Electricidad of Argentina as well as the controls and environmental corrective actions implemented at the Central Costanera, S.A. [Espanol] Se presenta una descripcion del equipo utilizado en la Central Costanera S.A. de Argentina, los requerimientos de gestion ambiental establecidos para esta central y las normas, resoluciones e instrumentos juridicos en materia ambiental. Se presenta ademas el plan de gestion ambiental del Ente Nacional Regulador de la Electricidad de Argentina asi como los controles y acciones correctivas ambientales implantadas en la Central Costanera S. A.

  5. The design and operation of the THORP central control room: a human factors perspective

    International Nuclear Information System (INIS)

    Reed, Julie.

    1996-01-01

    The new Thermal Oxide Reprocessing Plant (THORP) at British Nuclear Fuels (BNFL) Sellafield Site is now operational. This paper describes the Central Control Room (CCR), focusing on the control system components. Throughout the design, commissioning and operation of THORP, human factors played an important part. (author)

  6. Central display system of figures in fire alarm

    International Nuclear Information System (INIS)

    Fang Shaohong; Zhu Zicheng; Zhu Liqun; Ren Yi; Yu Hongmei; Du Chengbao; Xie Guoxue

    1997-01-01

    A new type of 'central display system of figures in fire alarm' includes two parts: (1) software package of drawing picture; (2) real time processing and operate system (POS). Main function of the software package is to draw floor plane figures, fire-fighting facility signs and room numbers; and then all pictures are used in POS. Main functions of POS are to process fire alarm, faults and activation of fire fighting control facility, save and print reports, look over floor plane figures, look over concrete condition of fire fighting facilities, and to show appropriate prompt according to different case. This system realizes many functions, such as, control with mouse, operation with push-button, menu operation interface, flip windows to prompt, and chinese character. It have won acclaim for its amazing interface, its convenience to operate, its reliability and flexibility

  7. The SSC field bus: A high-performance control system front end concentrator for 'slow' accelerator controls

    International Nuclear Information System (INIS)

    Haenni, D.R.; Saltmarsh, C.G.; Lue, H.C.; Hunt, S.M.

    1991-01-01

    The SSC control system must support a large number of 'slow' or industrial type control points. A front-end system is described which could serve as both a data concentrator and a distributed process controller for these points. Unlike many distributed control systems, this front end is designed to provide strong support for centralized controls. The live parameter data base in the central system can be updated at a rate which is fast compared to that usually needed for process control loops. Portions of this data base can be optionally replicated in regional computers to provide both local control stations and distributed control loops. In addition to the global and regional levels the system also allows the distribution of loops to the local I/O crate level. A possible implementation of this system is under development which is based on industrial standard STD-Bus for accelerator hardware interfacing, time domain multiplexing (TDM) for communications transport, and a form of reflective memory for the back-end interface to the rest of the control system

  8. Neuronal chemokines : Versatile messengers in central nervous system cell interaction

    NARCIS (Netherlands)

    de Haas, A. H.; van Weering, H. R. J.; de Jong, E. K.; Boddeke, H. W. G. M.; Biber, K. P. H.

    2007-01-01

    Whereas chemokines are well known for their ability to induce cell migration, only recently it became evident that chemokines also control a variety of other cell functions and are versatile messengers in the interaction between a diversity of cell types. In the central nervous system (CNS),

  9. Status of the BEPC control system

    International Nuclear Information System (INIS)

    Zhao Jijiu; Yan Yonghe; Zhan Mingchuan; Yu Yulan; Luo Huiying; Wang Yaru; Geng Xiaosong

    1994-01-01

    The control system of the Beijing Electron Positron Collider (BEPC) was built by the end of 1987. Since then, it has been running safely and reliably. Due to the tight construction schedule, we adopted the control system structure of the new SPEAR of SLAC, which was a centralized control system. The system was not performing very well due to various problems such as low CPU power, limited memory of the VAX-11/750 control computer, a bottle-neck of the VAX-CAMAC-Channel etc. Since 1991 we have therefore been working on upgrading it to a distributed control system based on DECnet. The old console will be replaced by VAX-4090 workstations. The status of the system and the progress of the upgrading work are presented in this paper. ((orig.))

  10. Architecture of distributed control system at Hazira (Paper No. 3.2)

    International Nuclear Information System (INIS)

    Nema, V.P.

    1992-01-01

    The architecture of control system at Heavy Water Plant, Hazira has a physically centralized and functionally de-centralized configuration. The sub-systems for the functional areas such as automation system (AS), operating and monitoring system (OS) and communication system (CS) are described. (author). 3 figs

  11. Bioengineered Hydrogel to Inhibit Post-Traumatic Central Nervous System Scarring

    Science.gov (United States)

    2016-10-01

    necessary to unlock the full therapeutic value of stem cell -based regenerative therapies. The present proposal takes advantage of a long- standing, cross...the Journal of Controlled Release (J Control Release. 2015 Jun 28;208:76-84). 15. SUBJECT TERMS prevalence, trauma, hydrogel, stem cell therapy...cavitations that are not spontaneously repaired. Early after injury, blood enters the central nervous system (CNS) and directly kills brain cells but also

  12. Controlling Price-Responsive Heat Pumps for Overload Elimination in Distribution Systems

    DEFF Research Database (Denmark)

    Csetvei, Zsuzsa; Østergaard, Jacob; Nyeng, Preben

    2011-01-01

    This paper investigates the possibility of applying electric heat pumps with the control-by-price-concept in order to avoid overload in a local distribution system. The proposed control algorithm is based upon a centrally dispatched real-time market price, reflecting the state of a larger power...... system, and is extended with a local price control for overload elimination on the corresponding feeder. The paper presents the mathematical models of a two-node system with price-responsive heat pumps, the chosen methodology of the central price calculation, and the proposed local feedback control...

  13. Central nervous system mesenchymal chondrosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Salvati, M.; Frati, A.; Piccirilli, M.; Agrillo, A.; Brogna, C.; Occhiogrosso, G.; Giangaspero, F. [INM Neuromed IRCCS, Pozzilli (Italy). Dept. of Neurosurgery; Caroli, E. [Policlinico S. Andrea, Rome (Italy). Dept. of Neurological Sciences, Neurosurgery

    2005-06-15

    Central nervous system mesenchymal chondrosarcomas are rare malignant tumors that constitute a separate entity from the classical chondrosarcoma and myxoid variant. Clinical behaviour of central nervous system chondrosarcomas is still unknown. We describe two rare examples of intracranial mesenchymal chondrosarcoma with a review of the literature, in an attempt to clarify the clinical characteristics, prognosis and treatment of choice of these unusual tumors. Among the 55 reported cases, 23 had postoperative radiotherapy. Although there is no statistical significance according to the Log-Rank test (p=0.7), the patients treated with radiation therapy seem to have a better chance of survival. Patients who had adjuvant chemotherapy (only 5) showed survival times similar to those patients who had none. Although clinical behaviour of central nervous system chondrosarcomas remains to be defined, data from our series as well as literature show that radical removal is the best therapeutic choice. In addition, patients treated with postoperative radiotherapy seem to show a trend toward increased survival.

  14. Central nervous system mesenchymal chondrosarcoma

    International Nuclear Information System (INIS)

    Salvati, M.; Frati, A.; Piccirilli, M.; Agrillo, A.; Brogna, C.; Occhiogrosso, G.; Giangaspero, F.; Caroli, E.

    2005-01-01

    Central nervous system mesenchymal chondrosarcomas are rare malignant tumors that constitute a separate entity from the classical chondrosarcoma and myxoid variant. Clinical behaviour of central nervous system chondrosarcomas is still unknown. We describe two rare examples of intracranial mesenchymal chondrosarcoma with a review of the literature, in an attempt to clarify the clinical characteristics, prognosis and treatment of choice of these unusual tumors. Among the 55 reported cases, 23 had postoperative radiotherapy. Although there is no statistical significance according to the Log-Rank test (p=0.7), the patients treated with radiation therapy seem to have a better chance of survival. Patients who had adjuvant chemotherapy (only 5) showed survival times similar to those patients who had none. Although clinical behaviour of central nervous system chondrosarcomas remains to be defined, data from our series as well as literature show that radical removal is the best therapeutic choice. In addition, patients treated with postoperative radiotherapy seem to show a trend toward increased survival

  15. Central Gi(2) proteins, sympathetic nervous system and blood pressure regulation

    Czech Academy of Sciences Publication Activity Database

    Zicha, Josef

    2016-01-01

    Roč. 216, č. 3 (2016), s. 258-259 ISSN 1748-1708 Institutional support: RVO:67985823 Keywords : inhibitory G proteins * sympathetic nervous system * central blood pressure control Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 4.867, year: 2016

  16. The CEBAF control system for the CHL

    International Nuclear Information System (INIS)

    Keesee, M.S.; Bevins, B.S.

    1996-01-01

    The CEBAF Central Helium Liquefier (CHL) control system consists of independent safety controls located at each subsystem, CAMAC computer interface hardware, and a CEBAF-designed control software called Thaumaturgic Automated Control Logic (TACL). The paper describes how control software was interfaced with the subsystems of the CHL. Topics of configuration, editing, operator interface, datalogging, and internal logic functions are presented as they relate to the operational needs of the helium plant. The paper also describes the effort underway to convert from TACL to the Experimental Physics and Industrial Control System (EPICS), the new control system for the CEBAF accelerator. This software change will require customizing EPICS software to cryogenic process control

  17. 40 CFR 81.104 - Central Pennsylvania Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Quality Control Region. 81.104 Section 81.104 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.104 Central Pennsylvania Intrastate Air Quality Control Region. The Central Pennsylvania Intrastate Air Quality Control Region consists of the territorial area encompassed by...

  18. 40 CFR 81.47 - Central Oklahoma Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Quality Control Region. 81.47 Section 81.47 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.47 Central Oklahoma Intrastate Air Quality Control Region. The Metropolitan Oklahoma Intrastate Air Quality Control Region has been renamed the Central Oklahoma Intrastate...

  19. The integration of two control systems

    International Nuclear Information System (INIS)

    Bickley, M.; White, K.

    1995-01-01

    During the past year the Continuous Electron Beam Accelerator Facility (CEBAF) has installed a new machine control system, based on the Experimental Physics and Industrial Control System (EPICS). The migration from CEBAF's old control system, Thaumaturgic Automated Control Logic (TACL), had to be done concurrently with commissioning of the CEBAF accelerator. The smooth transition to EPICS was made possible by the similarity of the control systems' topological design and network communication protocol. Both systems have operator display computer nodes which are decoupled from the data acquisition and control nodes. The communication between display and control nodes of both control systems is based on making named requests for data, with data being passed on change of value. Due to TACL's use of a central communications process, it was possible to integrate both control systems' network communications in that process. This in turn meant that CEBAF did not require changes to any other software in order to support network communication between TACL and EPICS. CEBAF implemented the machine's control under EPICS in an evolutionary, controlled manner. 4 refs., 3 figs

  20. Control system for compact SR light source 'AURORA'

    International Nuclear Information System (INIS)

    Fukami, Nobutaka; Kariya, Hiroyuki; Yamada, Hironari

    1991-01-01

    The computer control system developed for 'AURORA' has a three level hierarchical architecture. The top level is Central Intelligence System (CIS), and the second one is Autonomic Control System (ACS). The bottom one is an assembly of distributed local controllers linked to the ACS level through optical fibers. This system provides fully automated operation, and a powerful machine study capability through the associated man-machine console and an interpretive operation language. (author)

  1. Accounting for and control of nuclear material at the Central Institute of Nuclear Research, Rossendorf

    International Nuclear Information System (INIS)

    Heidel, S.; Rossbander, W.; Helming, M.

    1983-01-01

    A survey is given of the system of accounting for and control of nuclear material at the Central Institute for Nuclear Research, Rossendorf. It includes 3 material balance areas. Control is implemented at both the institute and the MBA levels on the basis of concepts which are coordinated with the national control authority of the IAEA. The system applied enables national and international nuclear material control to be carried out effectively and economically at a minimum of interference with operational procedures. (author)

  2. Cell fate control in the developing central nervous system

    Energy Technology Data Exchange (ETDEWEB)

    Guérout, Nicolas; Li, Xiaofei; Barnabé-Heider, Fanie, E-mail: Fanie.Barnabe-Heider@ki.se

    2014-02-01

    The principal neural cell types forming the mature central nervous system (CNS) are now understood to be diverse. This cellular subtype diversity originates to a large extent from the specification of the earlier proliferating progenitor populations during development. Here, we review the processes governing the differentiation of a common neuroepithelial cell progenitor pool into mature neurons, astrocytes, oligodendrocytes, ependymal cells and adult stem cells. We focus on studies performed in mice and involving two distinct CNS structures: the spinal cord and the cerebral cortex. Understanding the origin, specification and developmental regulators of neural cells will ultimately impact comprehension and treatments of neurological disorders and diseases. - Highlights: • Similar mechanisms regulate cell fate in different CNS cell types and structures. • Cell fate regulators operate in a spatial–temporal manner. • Different neural cell types rely on the generation of a diversity of progenitor cells. • Cell fate decision is dictated by the integration of intrinsic and extrinsic signals.

  3. Cell fate control in the developing central nervous system

    International Nuclear Information System (INIS)

    Guérout, Nicolas; Li, Xiaofei; Barnabé-Heider, Fanie

    2014-01-01

    The principal neural cell types forming the mature central nervous system (CNS) are now understood to be diverse. This cellular subtype diversity originates to a large extent from the specification of the earlier proliferating progenitor populations during development. Here, we review the processes governing the differentiation of a common neuroepithelial cell progenitor pool into mature neurons, astrocytes, oligodendrocytes, ependymal cells and adult stem cells. We focus on studies performed in mice and involving two distinct CNS structures: the spinal cord and the cerebral cortex. Understanding the origin, specification and developmental regulators of neural cells will ultimately impact comprehension and treatments of neurological disorders and diseases. - Highlights: • Similar mechanisms regulate cell fate in different CNS cell types and structures. • Cell fate regulators operate in a spatial–temporal manner. • Different neural cell types rely on the generation of a diversity of progenitor cells. • Cell fate decision is dictated by the integration of intrinsic and extrinsic signals

  4. Fitting in of cogeneration into central heating systems; Inpassing warmte/kracht in cv-systemen

    Energy Technology Data Exchange (ETDEWEB)

    Rulkens, L.J.W. [FD-Bouwzaken, Ministerie van Landbouw, Natuurbeheer en Visserij LNV, Wageningen (Netherlands); Tijs, J.C. [Tijs Energy Systems, Wijk bij Duurstede (Netherlands); Wammes, J.A. [Emicon, Veenendaal (Netherlands)

    1997-02-01

    The choice for the size of a combined heat and power generating unit as well as the hydraulic and control engineering fitting in into existing central heating systems bears some pitfalls in practice. Those problems are inventorized and compiled for the manual `Design rules for the fitting in of cogeneration into central heating systems`. A brief overview is given of the contents of the manual. 3 figs., 3 ills., 1 tab.

  5. Control of the Tevatron Satellite Refrigeration system

    International Nuclear Information System (INIS)

    Theilacker, J.; Chapman, L.; Gannon, J.; Hentges, M.; Martin, M.; Rode, C.H.; Zagel, J.

    1984-01-01

    This chapter describes a computerized control system for 24 satellite refrigerators which cool a six kilometer ring of superconducting magnets. The control system consists of 31 independent microprocessors operating over 400 servo loops, and a central computer system which provides monitoring, alarms, logging and changing of parameters. Topics considered include pressure measurement, flow measurement, temperature measurement, gas analysis, control valves, expansion engine controllers, and control loops. Each refrigerator has 12 active microprocessor based control loops which tune the refrigerator to one of its four operating modes: satellite, liquefier, refrigerator, and stand-by. It is suggested that optimizing the refrigerator control loops and quench recovery scheme will minimize the accelerator down time

  6. Adult central nervous system

    International Nuclear Information System (INIS)

    Sutton, M.L.

    1985-01-01

    Historically, the adult central nervous system (CNS) was regarded as relatively immune to the effects of ionising radiation, and the recognition of the CNS as a radio-vulnerable structure occurred later than was the case for many other tissues. Increasingly precise knowledge of the time-dose-volume relationships for CNS tolerance has had two important consequences: (1) it has permitted the avoidance of catastrophic and usually lethal late effects in the brain and spinal cord when these tissues are unavoidably irradiated during the treatment of adjacent non-CNS tumours, and (2) it has encouraged referral for irradiation of certain technically benign lesions which, although compatible with prolonged survival, represent a continuing threat to the patient - for example arteriovenous malformations, pituitary adenomas, and some meningiomas. Many of these can now be controlled for very long periods following radiation doses consistent with the long-term functional integrity of the CNS

  7. Centralized environmental radiation monitoring system in JAERI

    International Nuclear Information System (INIS)

    Katagiri, Hiroshi; Kobayashi, Hideo

    1993-03-01

    Japan Atomic Energy Research Institute (JAERI) has continued the radiation background survey and environmental radiation monitoring to ensure the safety of the residents around the Institute. For the monitoring of β and γ radiations and α and β radioactivities in air, the centralized automatic environmental radiation monitoring system (EMS) applying a computer with monitoring stations (MS) was established. The system has been renewed twice in 1973 and 1988. In 1962, a new concept emergency environmental γ-ray monitoring system (MP) was begun to construct and completed in 1965 independent of EMS. The first renewal of the EMS was carried out by focusing on the rapid and synthetic judgement and estimation of the environmental impacts caused by radiation and radioactive materials due to the operation of nuclear facilities by centralizing the data measured at MS, MP, a meteorological station, stack monitors and drainage monitoring stations under the control of computer. Present system renewed in 1988 was designed to prevent the interruption of monitoring due to computer troubles, communication troubles and power failures especially an instant voltage drop caused by thunder by reflecting the experiences through the operation and maintenance of the former system. Dual telemeters whose power is constantly supplied via batteries (capable of 10 min. monitoring after power failure) are equipped in the monitoring center to cope with telemeter troubles, which has operated successfully without any suspension being attributable to the power failures and telemeter troubles. (J.P.N.)

  8. Tasks and structure of the WENDELSTEIN 7-X control system

    International Nuclear Information System (INIS)

    Schacht, Joerg; Niedermeyer, Helmut; Laqua, Heike; Spring, Anett; Mueller, Ina; Pingel, Steffen; Woelk, Andreas

    2006-01-01

    The super conducting stellarator WENDELSTEIN 7-X will run pulses of up to 30 min duration with full heating power. Short pulses with arbitrary intervals, steady state long discharges and arbitrary sequences of short phases with different characteristics in one discharge will be supported by the control system. Each technical component and each diagnostic system including its data acquisition will have its own control system permitting autonomous operation for commissioning and testing. During the experimental sessions the activity of these devices will be coordinated by a central control system and the machine runs more or less automatically with predefined programs. A session leader program allows the leader of the experiment to choose and chain predefined segments, to start or stop a segment chain as a discharge. The progress of the discharge is shown by a sequence monitor attached to the central sequence controller and the session leader program. W7-X has to be prepared for the experiment and monitored by means of the PLC based operational management system. A safety system working independently of the operational management consists of local units responsible for the safety of each component and a central unit ensuring the safety of the whole W7-X system. This safety system provides interlocks and controls the human access to the device. A safety analysis is the basis for the development of the safety system

  9. Embedded Control System for Smart Walking Assistance Device.

    Science.gov (United States)

    Bosnak, Matevz; Skrjanc, Igor

    2017-03-01

    This paper presents the design and implementation of a unique control system for a smart hoist, a therapeutic device that is used in rehabilitation of walking. The control system features a unique human-machine interface that allows the human to intuitively control the system just by moving or rotating its body. The paper contains an overview of the complete system, including the design and implementation of custom sensors, dc servo motor controllers, communication interfaces and embedded-system based central control system. The prototype of the complete system was tested by conducting a 6-runs experiment on 11 subjects and results are showing that the proposed control system interface is indeed intuitive and simple to adopt by the user.

  10. Nova laser alignment control system

    International Nuclear Information System (INIS)

    Van Arsdall, P.J.; Holloway, F.W.; McGuigan, D.L.; Shelton, R.T.

    1984-01-01

    Alignment of the Nova laser requires control of hundreds of optical components in the ten beam paths. Extensive application of computer technology makes daily alignment practical. The control system is designed in a manner which provides both centralized and local manual operator controls integrated with automatic closed loop alignment. Menudriven operator consoles using high resolution color graphics displays overlaid with transport touch panels allow laser personnel to interact efficiently with the computer system. Automatic alignment is accomplished by using image analysis techniques to determine beam references points from video images acquired along the laser chain. A major goal of the design is to contribute substantially to rapid experimental turnaround and consistent alignment results. This paper describes the computer-based control structure and the software methods developed for aligning this large laser system

  11. TFTR diagnostic control and data acquisition system

    International Nuclear Information System (INIS)

    Sauthoff, N.R.; Daniels, R.E.; PPL Computer Division

    1985-01-01

    General computerized control and data-handling support for TFTR diagnostics is presented within the context of the Central Instrumentation, Control and Data Acquisition (CICADA) System. Procedures, hardware, the interactive man--machine interface, event-driven task scheduling, system-wide arming and data acquisition, and a hierarchical data base of raw data and results are described. Similarities in data structures involved in control, monitoring, and data acquisition afford a simplification of the system functions, based on ''groups'' of devices. Emphases and optimizations appropriate for fusion diagnostic system designs are provided. An off-line data reduction computer system is under development

  12. Operational advanced materials control and accountability system

    International Nuclear Information System (INIS)

    Malanify, J.J.; Bearse, R.C.; Christensen, E.L.

    1980-01-01

    An accountancy system based on the Dynamic Materials Accountability (DYMAC) System has been in operation at the Plutonium Processing Facility at the Los Alamos Scientific Laboratory (LASL) since January 1978. This system, now designated the Plutonium Facility/Los Alamos Safeguards System (PF/LASS), has enhanced nuclear material accountability and process control at the LASL facility. The nondestructive assay instruments and the central computer system are operating accurately and reliably. As anticipated, several uses of the system have developed in addition to safeguards, notably scrap control and quality control. The successes of this experiment strongly suggest that implementation of DYMAC-based systems should be attempted at other facilities. 20 refs

  13. Vertebrobasilar system computed tomographic angiography in central vertigo.

    Science.gov (United States)

    Paşaoğlu, Lale

    2017-03-01

    The incidence of vertigo in the population is 20% to 30% and one-fourth of the cases are related to central causes. The aim of this study was to evaluate computed tomography angiography (CTA) findings of the vertebrobasilar system in central vertigo without stroke.CTA and magnetic resonance images of patients with vertigo were retrospectively evaluated. One hundred twenty-nine patients suspected of having central vertigo according to history, physical examination, and otological and neurological tests without signs of infarction on diffusion-weighted magnetic resonance imaging were included in the study. The control group included 120 patients with similar vascular disease risk factors but without vertigo. Vertebral and basilar artery diameters, hypoplasias, exit-site variations of vertebral artery, vertebrobasilar tortuosity, and stenosis of ≥50% detected on CTA were recorded for all patients. Independent-samples t test was used in variables with normal distribution, and Mann-Whitney U test in non-normal distribution. The difference of categorical variable distribution according to groups was analyzed with χ and/or Fisher exact test.Vertebral artery hypoplasia and ≥50% stenosis were seen more often in the vertigo group (P = 0.000, vertigo patients had ≥50% stenosis, 54 (69.2%) had stenosis at V1 segment, 9 (11.5%) at V2 segment, 2 (2.5%) at V3 segment, and 13 (16.6%) at V4 segment. Both vertigo and control groups had similar basilar artery hypoplasia and ≥50% stenosis rates (P = 0.800, >0.05).CTA may be helpful to clarify the association between abnormal CTA findings of vertebral arteries and central vertigo.This article reveals the opportunity to diagnose posterior circulation abnormalities causing central vertigo with a feasible method such as CTA.

  14. FNAL central email systems

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jack; Lilianstrom, Al; Pasetes, Ray; Hill, Kevin; /Fermilab

    2004-10-01

    The FNAL Email System is the primary point of entry for email destined for an employee or user at Fermilab. This centrally supported system is designed for reliability and availability. It uses multiple layers of protection to help ensure that: (1) SPAM messages are tagged properly; (2) All mail is inspected for viruses; and (3) Valid mail gets delivered. This system employs numerous redundant subsystems to accomplish these tasks.

  15. Design and construction of vacuum control system on EAST

    International Nuclear Information System (INIS)

    Wang, L.; Zhang, Y.; Hu, Q.S.; Wang, X.M.; Zhang, X.D.; Hu, J.S.; Yang, Y.; Gu, X.M.

    2008-01-01

    The construction of experimental advanced superconducting tokamak (EAST) was finished at the end of 2006 in Hefei, China. Its vacuum system, an important subsystem, has been commissioned in February 2006. The design and construction of this vacuum control system are described in this paper. The requirements for remote automation, distributed control and centralized management, high reliability and expansibility have been taken into account in the design. There are three levels of control in vacuum control system. The bottom level control is performed on the local instruments manually; the medium level control is based on Siemens S7-400 PLC; the top level control is conducted on IPCs with communication through profi b us network. In addition remote handling and centralized monitoring could be realized by a remote control server. The control system could achieve pumping and fueling of the whole vacuum system. Besides that, it also includes the data acquisition of the pressure and temperature. The details are discussed on the monitoring of vacuum system states including cooling water, power and compressed air, etc., safeguards of plasma chamber and cryostat chamber and vacuum equipments, choosing of control modes corresponding to the plasma discharge and wall conditioning. At the end, the parts of EAST device protection system related to vacuum and gas injection system will also be introduced

  16. Distributed control system for parallel-connected DC boost converters

    Science.gov (United States)

    Goldsmith, Steven

    2017-08-15

    The disclosed invention is a distributed control system for operating a DC bus fed by disparate DC power sources that service a known or unknown load. The voltage sources vary in v-i characteristics and have time-varying, maximum supply capacities. Each source is connected to the bus via a boost converter, which may have different dynamic characteristics and power transfer capacities, but are controlled through PWM. The invention tracks the time-varying power sources and apportions their power contribution while maintaining the DC bus voltage within the specifications. A central digital controller solves the steady-state system for the optimal duty cycle settings that achieve a desired power supply apportionment scheme for a known or predictable DC load. A distributed networked control system is derived from the central system that utilizes communications among controllers to compute a shared estimate of the unknown time-varying load through shared bus current measurements and bus voltage measurements.

  17. Control system for the Spanish Stellarator TJ-II

    International Nuclear Information System (INIS)

    Pacios, L.; Blaumoser, M.; Pena, A. de la; Carrasco, R.; Labrador, I.; Lapayese, F.; Diaz, J.C.; Laso, L.M.

    1995-01-01

    We describe the distributed control and monitoring system for the Spanish Stellarator TJ-II, which is under construction at CIEMAT in Madrid. It consists of one central UNIX workstation and several autonomous subsystems based on VME crates with embedded processors under OS-9 real-time operating system and PLCs. The system integrates the machine and discharge control. An operator can perform the control and plasma discharge by means of a user-friendly graphic interface. (orig.)

  18. A computer control system for a research reactor

    International Nuclear Information System (INIS)

    Crawford, K.C.; Sandquist, G.M.

    1987-01-01

    Most reactor applications until now, have not required computer control of core output. Commercial reactors are generally operated at a constant power output to provide baseline power. However, if commercial reactor cores are to become load following over a wide range, then centralized digital computer control is required to make the entire facility respond as a single unit to continual changes in power demand. Navy and research reactors are much smaller and simpler and are operated at constant power levels as required, without concern for the number of operators required to operate the facility. For navy reactors, centralized digital computer control may provide space savings and reduced personnel requirements. Computer control offers research reactors versatility to efficiently change a system to develop new ideas. The operation of any reactor facility would be enhanced by a controller that does not panic and is continually monitoring all facility parameters. Eventually very sophisticated computer control systems may be developed which will sense operational problems, diagnose the problem, and depending on the severity of the problem, immediately activate safety systems or consult with operators before taking action

  19. Chapter 1. Central nervous system

    International Nuclear Information System (INIS)

    Planiol, T.; Veyre, A.; Plagne, R.

    1975-01-01

    The present situation with regard to explorations of the central nervous system by radioactive compounds is reviewed. For the sake of clarity the brain and cerebrospinal fluid examinations are described separately, with emphasis nevertheless on their complementarity. The tracers used in each of these examinations are listed, together with the criteria governing their choice. The different techniques employed are described. Scintigraphy is presented apart from gamma-angio-encephalography since it is not possible with rectilinear scintigraphs to observe the circulatory phase. The results are interpreted by an analysis of normal and pathological aspects of the different stages of the central nervous system [fr

  20. Overview and status of the system control of WENDELSTEIN 7-X

    International Nuclear Information System (INIS)

    Schacht, J.; Laqua, H.; Lewerentz, M.; Mueller, I.; Pingel, S.; Spring, A.; Woelk, A.

    2006-01-01

    The new quality of the superconducting fusion device W7-X is its capability for long-pulse operation. Discharge operations can be up to 30 minutes with full heating power. Considering the steady state operation capability the W7-X system control will be important for future long-term fusion experiments. A wide spectrum of requirements has to be considered during design and realization of the system control of W7-X. The experimental nature of the W7-X project requires high flexibility for machine operation and automatic program controlled operation. During the planned life cycle of about two decades the scientific programs will be permanently adapted to new aspects. New components will be included into the control system and established systems have to be adapted with respect to technological progress. The device W7-X is a very complex technical system. On the top of the hierarchically structured system control the central control system is located. Local components, e.g. power supplies, heating systems, and diagnostics, have their own control systems. For commissioning and tests local systems will be run autonomously. In preparation for experiment operation all essential components will be subordinated to the central control system. During experiments the central control system coordinates the activity of these components. A special segment control system is responsible for processing predefined programs. The configuration of a discharge phase can be set very flexible: Short pulses with arbitrary intervals, steady state long discharges and arbitrary sequences of short phases with different characteristics in one discharge will be supported by the segment control system. The interactive session leader program allows to choose and chain predefined segment programs, to start or stop a segment program chain as a discharge. The progress of the discharge is visualized by a sequence monitor. The independent safety system consists of local units responsible for the safety

  1. Inventory management and control at the central distribution center for Univar Products International B.V.

    NARCIS (Netherlands)

    Pholnukulkit, Pimara

    2008-01-01

    This report presents the outcome of the Logistics Design Project carried out for Univar Products International B.V. The goal of this project is to design an inventory control system and implement an inventory control tool that supports decisions in managing inventory of all products in the central

  2. Concurrent control system for the JAERI tandem accelerator

    International Nuclear Information System (INIS)

    Hanashima, Susumu; Shozi, Tokio; Shiozaki, Yasuo; Saito, Motoi; Oogane, Yasuo; Sekiguchi, Satoshi.

    1994-01-01

    A new control system for the JAERI tandem accelerator is constructed. The system utilizes concurrent processing technology with multiprocessor. Transputers are used both for central processor and I/O front end processors. (author)

  3. Dynamic optimal control of homeostasis: an integrative system approach for modeling of the central nitrogen metabolism in Saccharomyces cerevisiae.

    Science.gov (United States)

    van Riel, N A; Giuseppin, M L; Verrips, C T

    2000-01-01

    The theory of dynamic optimal metabolic control (DOMC), as developed by Giuseppin and Van Riel (Metab. Eng., 2000), is applied to model the central nitrogen metabolism (CNM) in Saccharomyces cerevisiae. The CNM represents a typical system encountered in advanced metabolic engineering. The CNM is the source of the cellular amino acids and proteins, including flavors and potentially valuable biomolecules; therefore, it is also of industrial interest. In the DOMC approach the cell is regarded as an optimally controlled system. Given the metabolic genotype, the cell faces a control problem to maintain an optimal flux distribution in a changing environment. The regulation is based on strategies and balances feedback control of homeostasis and feedforward regulation for adaptation. The DOMC approach is an integrative, holistic approach, not based on mechanistic descriptions and (therefore) not biased by the variation present in biochemical and molecular biological data. It is an effective tool to structure the rapidly increasing amount of data on the function of genes and pathways. The DOMC model is used successfully to predict the responses of pulses of ammonia and glutamine to nitrogen-limited continuous cultures of a wild-type strain and a glutamine synthetase-negative mutant. The simulation results are validated with experimental data.

  4. The central noradrenergic system: an overview | Viljoen | African ...

    African Journals Online (AJOL)

    The central noradrenergic system belongs to a group of brainstem neuromodulatory systems previously referred to as the ascending reticular activating system. In this article a heuristic model is presented of the central noradrenergic system depicting the major projections to other cerebral areas, its interactions with other ...

  5. Central chemoreceptors and neural mechanisms of cardiorespiratory control

    Directory of Open Access Journals (Sweden)

    T.S. Moreira

    2011-09-01

    Full Text Available The arterial partial pressure (P CO2 of carbon dioxide is virtually constant because of the close match between the metabolic production of this gas and its excretion via breathing. Blood gas homeostasis does not rely solely on changes in lung ventilation, but also to a considerable extent on circulatory adjustments that regulate the transport of CO2 from its sites of production to the lungs. The neural mechanisms that coordinate circulatory and ventilatory changes to achieve blood gas homeostasis are the subject of this review. Emphasis will be placed on the control of sympathetic outflow by central chemoreceptors. High levels of CO2 exert an excitatory effect on sympathetic outflow that is mediated by specialized chemoreceptors such as the neurons located in the retrotrapezoid region. In addition, high CO2 causes an aversive awareness in conscious animals, activating wake-promoting pathways such as the noradrenergic neurons. These neuronal groups, which may also be directly activated by brain acidification, have projections that contribute to the CO2-induced rise in breathing and sympathetic outflow. However, since the level of activity of the retrotrapezoid nucleus is regulated by converging inputs from wake-promoting systems, behavior-specific inputs from higher centers and by chemical drive, the main focus of the present manuscript is to review the contribution of central chemoreceptors to the control of autonomic and respiratory mechanisms.

  6. Upgrade of the COMPASS tokamak real-time control system

    Energy Technology Data Exchange (ETDEWEB)

    Janky, F., E-mail: filip.janky.work@gmail.com [Institute of Plasma Physics, AS CR, v.v.i., Association EURATOM/IPP.CR, Za Slovankou 3, 18200 Prague (Czech Republic); Charles University in Prague, Faculty of Mathematics and Physics, V Holesovickach 2, 18000 Prague (Czech Republic); Havlicek, J. [Institute of Plasma Physics, AS CR, v.v.i., Association EURATOM/IPP.CR, Za Slovankou 3, 18200 Prague (Czech Republic); Charles University in Prague, Faculty of Mathematics and Physics, V Holesovickach 2, 18000 Prague (Czech Republic); Batista, A.J.N. [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, 1049-001 Lisboa (Portugal); Kudlacek, O.; Seidl, J. [Institute of Plasma Physics, AS CR, v.v.i., Association EURATOM/IPP.CR, Za Slovankou 3, 18200 Prague (Czech Republic); Neto, A.C. [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, 1049-001 Lisboa (Portugal); Pipek, J.; Hron, M. [Institute of Plasma Physics, AS CR, v.v.i., Association EURATOM/IPP.CR, Za Slovankou 3, 18200 Prague (Czech Republic); Mikulin, O. [Institute of Plasma Physics, AS CR, v.v.i., Association EURATOM/IPP.CR, Za Slovankou 3, 18200 Prague (Czech Republic); Czech Technical University, Faculty of Nuclear Sciences and Physical Engineering, V Holesovickach 2, 18000 Prague (Czech Republic); and others

    2014-03-15

    Highlights: • An upgrade of the COMPASS real-time system has been made to generally improve the plasma performance. • Stability of discharges in SNT configuration has been increased. • Plasma flat-top phase length has been extended. • Central solenoid protection has been developed. • Plasma position estimation has been improved. - Abstract: The COMPASS plasma control system is based on the MARTe real-time framework. Thanks to MARTe modularity and flexibility new algorithms have been developed for plasma diagnostic (plasma position calculation), control (shaping field control), and protection systems (central solenoid protection). Moreover, the MARTe framework itself was modified to broaden the communication capabilities via Aurora. This paper presents the recent upgrades and improvements made to the COMPASS real-time plasma control system, focusing on the issues related to precision of the real-time calculations, and discussing the improvements in terms of discharge parameters and stability. In particular, the new real-time system has given the possibility to analyze and to minimize the transport delays of each control loop.

  7. Epilepsy and other central nervous system diseases in atypical autism: a case control study

    DEFF Research Database (Denmark)

    Mouridsen, Svend Erik; Rich, Bente; Isager, Torben

    2011-01-01

    There is an increased but variable risk of epilepsy in autism spectrum disorders. The objective of this study is to compare the prevalence and types of epilepsy and other central nervous system (CNS) diseases in a clinical sample of 89 individuals diagnosed as children with atypical autism (AA...

  8. The central noradrenergic system

    African Journals Online (AJOL)

    2006-07-27

    Jul 27, 2006 ... recognition of a direct influence of the central noradrenergic system on peripheral ... influences on cerebral function and behavior it is impossible to imagine ... stimuli and to speed-up information processing.4. The influence of ...

  9. Evaluation of central nervous system in patients with glycogen storage disease type 1a.

    Science.gov (United States)

    Aydemir, Yusuf; Gürakan, Figen; Saltık Temizel, İnci Nur; Demir, Hülya; Oğuz, Kader Karlı; Yalnızoğlu, Dilek; Topçu, Meral; Özen, Hasan; Yüce, Aysel

    2016-01-01

    We aimed to evaluate structure and functions of central nervous system (CNS) in children with glycogen storage disease (GSD) type 1a. Neurological examination, psychometric tests, electroencephalography (EEG), magnetic resonance imaging (MRI), visual evoked potentials (VEP) and brainstem auditory evoked potentials (BAEP) were performed. The results were compared between patients with good and poor metabolic control and healthy children. Twenty-three patients with GSD type 1a were studied. Twelve patients were in poor metabolic control group and 11 patients in good metabolic control group. Five patients had intellectual disability, 10 had EEG abnormalities, seven had abnormal VEP and two had abnormal BAEP results. MRI was abnormal in five patients. There was significant correlation between the number of hypoglycemic attacks and MRI abnormalities. Central nervous system may be affected in GSD type 1a even in patients with normal neurologic examination. Accumulation of abnormal results in patients with poor metabolic control supports the importance of metabolic control in GSD type 1a.

  10. The influence of mechanical vibration on local and central balance control.

    Science.gov (United States)

    Ehsani, Hossein; Mohler, Jane; Marlinski, Vladimir; Rashedi, Ehsan; Toosizadeh, Nima

    2018-04-11

    Fall prevention has an indispensable role in enhancing life expectancy and quality of life among older adults. The first step to prevent falls is to devise reliable methods to identify individuals at high fall risk. The purpose of the current study was to assess alterations in local postural muscle and central sensory balance control mechanisms due to low-frequency externally applied vibration among elders at high fall risk, in comparison with healthy controls, as a potential tool for assessing fall risk. Three groups of participants were recruited: healthy young (n = 10; age = 23 ± 2 years), healthy elders (n = 10; age = 73 ± 3 years), and elders at high fall risk (n = 10; age = 84 ± 9 years). Eyes-open and eyes-closed upright standing balance performance was measured with no vibration, 30 Hz, and 40 Hz vibration of Gastrocnemius muscles. When vibratory stimulation was applied, changes in local-control performance manifested significant differences among the groups (p fall risk participants when compared to healthy young and older adults, respectively. On the other hand, vibration-induced changes in the central-control performance were not significant between groups (p ≥ 0.19). Results suggest that local-control deficits are responsible for balance behavior alterations among elders at high fall risk and healthy individuals. This observation may be attributable to deterioration of short-latency reflexive loop in elders at high fall risk. On the other hand, we could not ascribe the balance alterations to problems related to central nervous system performance or long-latency responses. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. [Central nervous system involvement in systemic lupus erythematosus - diagnosis and therapy].

    Science.gov (United States)

    Szmyrka, Magdalena

    Nervous system involvement in lupus belongs to its severe complications and significantly impacts its prognosis. Neuropsychiatric lupus includes 19 disease manifestations concerning both central and peripheral nervous system. This paper presents clinical aspects of central nervous system involvement in lupus. It reviews its epidemiology, risk factors and principles of diagnosis and therapy.

  12. Structurally Controlled Geothermal Systems in the Central Cascades Arc-Backarc Regime, Oregon

    Energy Technology Data Exchange (ETDEWEB)

    Wannamaker, Philip E. [Univ. of Utah, Salt Lake City, UT (United States). Energy and Geoscience Inst. (EGI)

    2016-07-31

    The goal of this project has been to analyze available magnetotelluric (MT) geophysical surveys, structural geology based on mapping and LiDAR, and fluid geochemical data, to identify high-temperature fluid upwellings, critically stressed rock volumes, and other evidence of structurally-controlled geothermal resources. Data were to be integrated to create conceptual models of volcanic-hosted geothermal resources along the Central Cascades arc segment, especially in the vicinity of Mt. Jefferson to Three Sisters. LiDAR data sets available at Oregon State University (OSU) allowed detailed structural geology modeling through forest canopy. Copious spring and well fluid chemistries, including isotopes, were modeled using Geo-T and TOUGHREACT software.

  13. Central nervous system resuscitation

    DEFF Research Database (Denmark)

    McIntosh, T K; Garde, E; Saatman, K E

    1997-01-01

    Traumatic injury to the central nervous system induces delayed neuronal death, which may be mediated by acute and chronic neurochemical changes. Experimental identification of these injury mechanisms and elucidation of the neurochemical cascade following trauma may provide enhanced opportunities...

  14. NO{sub x} controls for coal-fired utility boilers in East Central Europe

    Energy Technology Data Exchange (ETDEWEB)

    Eskinazi, D. [Electric Power Research Inst., Washington, DC (United States); Tavoulareas, E.S. [Energy Technologies Enterprises Corp., McLean, VA (United States)

    1995-12-01

    Increasing environmental pressures worldwide, including East Central Europe are placing greater emphasis on NO{sub x} emission controls in utility power plants. Western Europe, Japan and the U.S. have significant experience in applying NO{sub x} controls, especially in boilers firing hard coal. Some countries in Europe (i.e., Germany and Austria), have gained experience in applying NO{sub x} controls in boilers firing low-rank coal. This experience can be applied to East Central European countries in providing the basis for planning NO{sub x} control projects, suggesting cost-effective solutions, and providing lessons learned. However, while the experience is generally applicable to East Central European countries, differences in boiler design, operation and coal characteristics also need to be considered. This paper begins with a comparison of the NO{sub x} regulations, identifies the key NO{sub x} control technologies and the worldwide experience with them, and discusses the achievable NO{sub x} reduction, O&M impacts, and retrofit costs for each technology. Emphasis is placed on retrofit applications for existing boilers, because new coal-fired power plants are not expected to be built for the next 5-10 years. This paper also focuses on technologies with relatively low cost and operational simplicity: combustion system tuning/optimization. low-NO{sub x} burners (LNB), overfire air (OFA), selective non-catalytic reduction (SNCR), and reburning.

  15. Dealing with distributed intelligence in monitoring and control systems

    International Nuclear Information System (INIS)

    McLaren, R.A.

    1981-01-01

    The Euorpean Hybrid Spectrometer is built up of many individual detectors, each having widely varying monitoring and control requirements. With the advent of cheap microprocessor systems a shift from the concept of a single monitoring and control computer of that of distributed intelligent controllers has been economically feasible. A detector designer can now thoroughly test and debug a complete monitoring and control system on a local, dedicated micro-computer, while during operation, the central computer can be relieved of many simple repetitive tasks. Rapidly, however, it has become obvious that the designers of these systems have to take into account the final operational environment and build into both the hardware and software, features allowing easy integration into a central monitoring and control chain. In addition, the problems of maintenance and enventual modification have to be taken into consideration early in the development. Examples of currently operational systems will be briefly described to demonstrate how a set of basic guidelines plus standardisation of hardware/software can minimise the problems of integration and maintenance. Based on practical experience gained in the European Hybrid Spectrometer, investigations are proceeding on various possible alternatives for future micro-computer based monitoring and control systems. (orig.)

  16. Distributed generation and centralized power system in Thailand

    DEFF Research Database (Denmark)

    Sukkumnoed, Decharut

    2004-01-01

    The paper examines and discusses conflicts between the development of distributed power and centralized power system.......The paper examines and discusses conflicts between the development of distributed power and centralized power system....

  17. High-fat diet feeding differentially affects the development of inflammation in the central nervous system.

    Science.gov (United States)

    Guillemot-Legris, Owein; Masquelier, Julien; Everard, Amandine; Cani, Patrice D; Alhouayek, Mireille; Muccioli, Giulio G

    2016-08-26

    Obesity and its associated disorders are becoming a major health issue in many countries. The resulting low-grade inflammation not only affects the periphery but also the central nervous system. We set out to study, in a time-dependent manner, the effects of a high-fat diet on different regions of the central nervous system with regard to the inflammatory tone. We used a diet-induced obesity model and compared at several time-points (1, 2, 4, 6, 8, and 16 weeks) a group of mice fed a high-fat diet with its respective control group fed a standard diet. We also performed a large-scale analysis of lipids in the central nervous system using HPLC-MS, and we then tested the lipids of interest on a primary co-culture of astrocytes and microglial cells. We measured an increase in the inflammatory tone in the cerebellum at the different time-points. However, at week 16, we evidenced that the inflammatory tone displayed significant differences in two different regions of the central nervous system, specifically an increase in the cerebellum and no modification in the cortex for high-fat diet mice when compared with chow-fed mice. Our results clearly suggest region-dependent as well as time-dependent adaptations of the central nervous system to the high-fat diet. The differences in inflammatory tone between the two regions considered seem to involve astrocytes but not microglial cells. Furthermore, a large-scale lipid screening coupled to ex vivo testing enabled us to identify three classes of lipids-phosphatidylinositols, phosphatidylethanolamines, and lysophosphatidylcholines-as well as palmitoylethanolamide, as potentially responsible for the difference in inflammatory tone. This study demonstrates that the inflammatory tone induced by a high-fat diet does not similarly affect distinct regions of the central nervous system. Moreover, the lipids identified and tested ex vivo showed interesting anti-inflammatory properties and could be further studied to better characterize

  18. Gross anatomy of central nervous system in firefly, Pteroptyx tener (Coleoptera: Lampyridae)

    Science.gov (United States)

    Hudawiyah, Nur; Wahida, O. Nurul; Norela, S.

    2015-09-01

    This paper describes for the first time the organization and fine structure of the central nervous system (CNS) in the fireflies, Pteroptyx tener (Coleoptera: Lampyridae). The morphology of the CNS was examined by using Carl Zeiss AxioScope A1 photomicroscope with iSolution Lite software. Some specific structural features such as the localization of protocerebrum, deutocerebrum and tritocerebrum in the brain region were analyzed. Other than that, the nerve cord and its peripheral structure were also analyzed. This study suggests that, there is a very obvious difference between male and female central nervous system which illustrates that they may differ in function in controlling physiological and behavioral activities.

  19. Radiation exposure and central nervous system cancers: A case-control study among workers at two nuclear facilities

    International Nuclear Information System (INIS)

    Carpenter, A.V.; Flanders, W.D.; Frome, E.L.; Crawford-Brown, D.J.; Fry, S.A.

    1987-03-01

    A nested case-control study was conducted among workers employed between 1943 and 1977 at two nuclear facilities to investigate the possible association of primary malignant neoplasms of the central nervous system (CNS) with occupational exposure to ionizing radiation from external and internal sources. Eighty-nine white male and female workers, who according to the information on death certificates dies of primary CNS cancers, were identified as cases. Four matched controls were selected for each case. External radiation exposure data were available from film badge readings for individual workers, whereas radiation dose to lung from internally deposited radionuclides, mainly uranium, was estimated from area and personnel monitoring data and was used in analyses in lieu of the dose to the brain. Matched sets were included in the analyses only if information was available for the case and at least one of the corresponding controls. Thus, the analyses of external radiation included 27 cases and 90 matched controls, and 47 cases and 120 matched controls were analyzed for the effects of radiation from internally deposited uranium. No association was observed between deaths fron CNS cancers and occupational exposure to ionizing radiation from external or internal sources. However, due to the small number of monitored subjects and low doses, a weak association could not be ruled out. 43 refs., 1 fig., 15 tabs

  20. Operation of the Upgraded ATLAS Level-1 Central Trigger System

    CERN Document Server

    Glatzer, Julian Maximilian Volker; The ATLAS collaboration

    2015-01-01

    The ATLAS Level-1 Central Trigger (L1CT) system is a central part of ATLAS data-taking and has undergone a major upgrade for Run 2 of the LHC, in order to cope with the expected increase of instantaneous luminosity of a factor of 2 with respect to Run 1. The upgraded hardware offers more flexibility in the trigger decisions due to the double amount of trigger inputs and usable trigger channels. It also provides an interface to the new topological trigger system. Operationally - particularly useful for commissioning, calibration and test runs - it allows concurrent running of up to 3 different sub-detector combinations. In this contribution, we give an overview of the operational software framework of the L1CT system with particular emphasis of the configuration, controls and monitoring aspects. The software framework allows a consistent configuration with respect to the ATLAS experiment and the LHC machine, upstream and downstream trigger processors, and the data acquisition. Trigger and dead-time rates are m...

  1. Effectiveness of a large mimic panel in an existing nuclear power plant central control board

    International Nuclear Information System (INIS)

    Kubota, Ryuji; Satoh, Hiroyuki; Sasajima, Katsuhiro; Kawano, Ryutaro; Shibuya Shinya

    1999-01-01

    We conducted the analysis of the nuclear power plant (NPP) operators' behaviors under emergency conditions by using training simulators as a joint research project by Japanese BWR groups for twelve years. In the phase-IV of this project we executed two kinds of experiments to evaluate the effectiveness of the interfaces. One was for evaluations of the interfaces such as CRTs with touch screen, a large mimic panel, and a hierarchical annunciator system introduced in the newly developed ABWR type central control board. The other was that we analyzed the operators' behaviors in emergency conditions by using the first generation BWR type central control board which was added new interfaces such as a large display screen and demarcation on the board to help operators to understand the plant. The demarcation is one of the visual interface improvements and its technique is that a line enclosing several components causes them to be perceived as a group.The result showed that both the large display panel Introduced in ABWR central control board and the large display screen in the existing BWR type central control board improved the performance of the NPP operators in the experiments. It was expected that introduction of the large mimic panel into the existing BWR type central control boards would improve operators' performance. However, in the case of actual installation of the large display board into the existing central control boards, there are spatial and hardware constraints. Therefore the size of lamps, lines connecting from symbols of the pumps or valves to the others' will have to be modified under these constraints. It is important to evaluate the displayed information on the large display board before actual installation. We made experiments to solve these problems by using TEPCO's research simulator which is added a large mimic panel. (author)

  2. Robust Power Management Control for Stand-Alone Hybrid Power Generation System

    International Nuclear Information System (INIS)

    Kamal, Elkhatib; Adouane, Lounis; Aitouche, Abdel; Mohammed, Walaa

    2017-01-01

    This paper presents a new robust fuzzy control of energy management strategy for the stand-alone hybrid power systems. It consists of two levels named centralized fuzzy supervisory control which generates the power references for each decentralized robust fuzzy control. Hybrid power systems comprises: a photovoltaic panel and wind turbine as renewable sources, a micro turbine generator and a battery storage system. The proposed control strategy is able to satisfy the load requirements based on a fuzzy supervisor controller and manage power flows between the different energy sources and the storage unit by respecting the state of charge and the variation of wind speed and irradiance. Centralized controller is designed based on If-Then fuzzy rules to manage and optimize the hybrid power system production by generating the reference power for photovoltaic panel and wind turbine. Decentralized controller is based on the Takagi-Sugeno fuzzy model and permits us to stabilize each photovoltaic panel and wind turbine in presence of disturbances and parametric uncertainties and to optimize the tracking reference which is given by the centralized controller level. The sufficient conditions stability are formulated in the format of linear matrix inequalities using the Lyapunov stability theory. The effectiveness of the proposed Strategy is finally demonstrated through a SAHPS (stand-alone hybrid power systems) to illustrate the effectiveness of the overall proposed method. (paper)

  3. TFTR control and monitoring system (CICADA)

    International Nuclear Information System (INIS)

    Daniels, R.E.

    1981-01-01

    The TFTR Central Instrumentation, Control and Data Acquisition System (CICADA) is described. This is a computer based system, supporting three types of user interfaces and supporting real time, terminal, and batch operations. Over one hundred graphic display generators will be supported by the system, four array processors will greatly increase the analysis capabilities, and closed circuit television will distribute performance data throughout the facility. Approximately twenty thousand points wll be interfaced to the system

  4. The computer control system for the CESR B factory

    International Nuclear Information System (INIS)

    Strohman, C.R.; Rice, D.H.; Peck, S.B.

    1992-01-01

    B factories present unique requirements for controls and instrumentation systems. High reliability is critical to achieving the integrated luminosity goals. The CESR-B upgrade at Cornell University will have a control system based on the architecture of the successful CESR control system, which uses a centralized database/massage routing system in a multiported memory, and VAX stations for all high-level control functions. The implementation of this architecture will address the deficiencies in the current implementation while providing the required performance and reliability. (author)

  5. Overview of the LHD central control room data monitoring environment

    International Nuclear Information System (INIS)

    Emoto, M.; Yoshinuma, M.; Yoshida, M.; Nakanishi, H.; Iwata, C.; Ohsuna, M.; Nonomura, M.; Imazu, S.; Yokota, M.; Aoyagi, M.; Ogawa, H.; Ida, K.; Watanabe, K.; Kaneko, O.

    2016-01-01

    Highlights: • In this paper, the data monitoring environments in the LHD central control room, for example, summary data graph and video monitoring tools are introduced. Also, the environments for the remote participants are introduced. - Abstract: During the Large Helical Device (LHD) experiments, many scientists and technical staff are working in the central control room to operate the experiment. They must manage the diagnostics and controlling devices referring to the results of the last plasma shot. Also, the experiment coordinator must decide the conditions for the subsequent experiments using the results. Furthermore, many scientists are participating in the experiment from remote sites. Therefore, it is important to share the information in the control room quickly, such as the results of the last plasma discharge, with the remote user as well as with the staff in the room. In this paper, the data monitoring environment in the LHD central control room is introduced.

  6. Overview of the LHD central control room data monitoring environment

    Energy Technology Data Exchange (ETDEWEB)

    Emoto, M., E-mail: emoto.masahiko@nifs.ac.jp; Yoshinuma, M.; Yoshida, M.; Nakanishi, H.; Iwata, C.; Ohsuna, M.; Nonomura, M.; Imazu, S.; Yokota, M.; Aoyagi, M.; Ogawa, H.; Ida, K.; Watanabe, K.; Kaneko, O.

    2016-11-15

    Highlights: • In this paper, the data monitoring environments in the LHD central control room, for example, summary data graph and video monitoring tools are introduced. Also, the environments for the remote participants are introduced. - Abstract: During the Large Helical Device (LHD) experiments, many scientists and technical staff are working in the central control room to operate the experiment. They must manage the diagnostics and controlling devices referring to the results of the last plasma shot. Also, the experiment coordinator must decide the conditions for the subsequent experiments using the results. Furthermore, many scientists are participating in the experiment from remote sites. Therefore, it is important to share the information in the control room quickly, such as the results of the last plasma discharge, with the remote user as well as with the staff in the room. In this paper, the data monitoring environment in the LHD central control room is introduced.

  7. Rapid prototyping of the Central Safety System for Nuclear Risk in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Scibile, L. [ITER Organization, CS 90 046, St. Paul-lez-Durance, Cedex (France); Ambrosino, G. [Consorzio CREATE, Universita degli Studi di Napoli Federico II, via Claudio 21, 80125, Napoli (Italy); De Tommasi, G., E-mail: detommas@unina.i [Consorzio CREATE, Universita degli Studi di Napoli Federico II, via Claudio 21, 80125, Napoli (Italy); Pironti, A. [Consorzio CREATE, Universita degli Studi di Napoli Federico II, via Claudio 21, 80125, Napoli (Italy)

    2010-07-15

    The Central Safety System for Nuclear Risk (CSS-N) coordinates the safety control systems to ensure nuclear safety for the ITER complex. Since the CSS-N is a safety critical system, its validation and commissioning play a very important role; in particular the required level of reliability must be demonstrated. In such a scenario, it is strongly recommended to use modeling and simulation tools since the early design phase. Indeed, the modeling tools will help in the definition of the control system requirements. Furthermore the models can than be used for the rapid prototyping of the safety system. Hardware-in-the-loop simulations can also be performed in order to assess the performance of the control hardware against a plant simulator. The proposed approach relies on the availability of a plant simulator to develop the prototype of the control system. This paper introduces the methodology used to design and develop both the CSS-N Oriented Plant Simulator and the CSS-N Prototype.

  8. Rapid prototyping of the Central Safety System for Nuclear Risk in ITER

    International Nuclear Information System (INIS)

    Scibile, L.; Ambrosino, G.; De Tommasi, G.; Pironti, A.

    2010-01-01

    The Central Safety System for Nuclear Risk (CSS-N) coordinates the safety control systems to ensure nuclear safety for the ITER complex. Since the CSS-N is a safety critical system, its validation and commissioning play a very important role; in particular the required level of reliability must be demonstrated. In such a scenario, it is strongly recommended to use modeling and simulation tools since the early design phase. Indeed, the modeling tools will help in the definition of the control system requirements. Furthermore the models can than be used for the rapid prototyping of the safety system. Hardware-in-the-loop simulations can also be performed in order to assess the performance of the control hardware against a plant simulator. The proposed approach relies on the availability of a plant simulator to develop the prototype of the control system. This paper introduces the methodology used to design and develop both the CSS-N Oriented Plant Simulator and the CSS-N Prototype.

  9. Central control of glucose homeostasis: the brain--endocrine pancreas axis.

    Science.gov (United States)

    Thorens, B

    2010-10-01

    A large body of data gathered over the last decades has delineated the neuronal pathways that link the central nervous system with the autonomic innervation of the endocrine pancreas, which controls alpha- and beta-cell secretion activity and mass. These are important regulatory functions that are certainly keys for preserving the capacity of the endocrine pancreas to control glucose homeostasis over a lifetime. Identifying the cells involved in controlling the autonomic innervation of the endocrine pancreas, in response to nutrient, hormonal and environmental cues and how these cues are detected to activate neuronal activity are important goals of current research. Elucidation of these questions may possibly lead to new means for preserving or restoring defects in insulin and glucagon secretion associated with type 2 diabetes. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  10. Studying the central control of food intake and obesity in rats Estudando em ratos o controle central da ingestão alimentar e a obesidade

    Directory of Open Access Journals (Sweden)

    Eliane Beraldi Ribeiro

    2009-02-01

    Full Text Available The central nervous system regulates energy intake and expenditure through a complex network of neurotransmitters and neuromodulators. It is of great interest to understand the relevance of these systems to the physiological control of energy balance and to the disturbances of obesity. The present paper discusses some of the methods to address this field used at the laboratory of Endocrine Physiology of Universidade Federal de São Paulo. Initially, different experimental models of rat obesity are presented, namely the hypothalamic induced monosodium glutamate model, the Zucker genetic model, and the dietary model. The principles of brain microdialysis are also presented, the technique applied to obtain representative samples of the extracellular fluid of brain sites involved in feeding control. The microdialysate levels of serotonin, an important anorexigenic neurotransmitter, are determined by HPLC with electrochemical detection. The immunoblot technique (Western blot is used to determine hypothalamic levels of proteins relevant to the anorexigenic effect of serotonin and to analyze the acute activation of the insulin signaling cascade in the hypothalamus. The final section addresses the potential applications of proteomics in the study of the central control of feeding.O sistema nervoso central controla a ingestão e o gasto de energia por meio de um complexo circuito de neurotransmissores e neuromoduladores. É de grande interesse entender a relevância fisiológica destes sistemas e o papel que desempenham nos distúrbios da obesidade. No presente artigo, discutem-se alguns dos métodos que têm sido utilizados no laboratório de Fisiologia Endócrina da Universidade Federal de São Paulo, em estudos neste campo. Inicialmente, são apresentados alguns modelos de obesidade experimental em ratos, como a obesidade hipotalâmica induzida por glutamato monossódico, o modelo genético Zucker e também obesidades induzidas por dieta. Comenta

  11. Central nervous system complications after liver transplantation.

    Science.gov (United States)

    Kim, Jeong-Min; Jung, Keun-Hwa; Lee, Soon-Tae; Chu, Kon; Roh, Jae-Kyu

    2015-08-01

    We investigated the diversity of central nervous system complications after liver transplantation in terms of clinical manifestations and temporal course. Liver transplantation is a lifesaving option for end stage liver disease patients but post-transplantation neurologic complications can hamper recovery. Between 1 January 2001 and 31 December 2010, patients who had undergone liver transplantation at a single tertiary university hospital were included. We reviewed their medical records and brain imaging data and classified central nervous system complications into four categories including vascular, metabolic, infectious and neoplastic. The onset of central nervous system complications was grouped into five post-transplantation intervals including acute (within 1 month), early subacute (1-3 months), late subacute (3-12 months), chronic (1-3 years), and long-term (after 3 years). During follow-up, 65 of 791 patients (8.2%) experienced central nervous system complications, with 30 occurring within 1 month after transplantation. Vascular etiology was the most common (27 patients; 41.5%), followed by metabolic (23; 35.4%), infectious (nine patients; 13.8%), and neoplastic (six patients). Metabolic encephalopathy with altered consciousness was the most common etiology during the acute period, followed by vascular disorders. An initial focal neurologic deficit was detected in vascular and neoplastic complications, whereas metabolic and infectious etiologies presented with non-focal symptoms. Our study shows that the etiology of central nervous system complications after liver transplantation changes over time, and initial symptoms can help to predict etiology. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Basement control in the development of the early cretaceous West and Central African rift system

    Science.gov (United States)

    Maurin, Jean-Christophe; Guiraud, René

    1993-12-01

    The structural framework of the Precambrian basement of the West and Central African Rift System (WCARS) is described in order to examine the role of ancient structures in the development of this Early Cretaceous rift system. Basement structures are represented in the region by large Pan-African mobile belts (built at ca. 600 Ma) surrounding the > 2 Ga West African, Congo and Sao Francisco cratons. Except for the small Gao trough (eastern Mali) located near the contact nappe of the Pan-African Iforas suture zone along the edge of the West African craton, the entire WCARS is located within the internal domains of the Pan-African mobile belts. Within these domains, two main structural features occur as the main basement control of the WCARS: (1) an extensive network of near vertical shear zones which trend north-south through the Congo, Brazil, Nigeria, Niger and Algeria, and roughly east-west through northeastern Brazil and Central Africa. The shear zones correspond to intra-continental strike-slip faults which accompanied the oblique collision between the West African, Congo, and Sao Francisco cratons during the Late Proterozoic; (2) a steep metamorphic NW-SE-trending belt which corresponds to a pre-Pan-African (ca. 730 Ma) ophiolitic suture zone along the eastern edge of the Trans-Saharian mobile belt. The post-Pan-African magmatic and tectonic evolution of the basement is also described in order to examine the state of the lithosphere prior to the break-up which occurred in the earliest Cretaceous. After the Pan-African thermo-tectonic event, the basement of the WCARS experienced a long period of intra-plate magmatic activity. This widespread magmatism in part relates to the activity of intra-plate hotspots which have controlled relative uplift, subsidence and occasionally block faulting. During the Paleozoic and the early Mesozoic, this tectonic activity was restricted to west of the Hoggar, west of Aïr and northern Cameroon. During the Late Jurassic

  13. Conceptual design of Remote Control System for EAST tokamak

    International Nuclear Information System (INIS)

    Sun, X.Y.; Wang, F.; Wang, Y.; Li, S.

    2014-01-01

    Highlights: • A new design conception for remote control for EAST tokamak is proposed. • Rich Internet application (RIA) was selected to implement the user interface. • Some security mechanism was used to fulfill security requirement. - Abstract: The international collaboration becomes popular in tokamak research like in many other fields of science, because the experiment facilities become larger and more expensive. The traditional On-site collaboration Model that has to spend much money and time on international travel is not fit for the more frequent international collaboration. The Remote Control System (RCS), as an extension of the Central Control System for the EAST tokamak, is designed to provide an efficient and economical way to international collaboration. As a remote user interface, the RCS must integrate with the Central Control System for EAST tokamak to perform discharge control function. This paper presents a design concept delineating a few key technical issues and addressing all significant details in the system architecture design. With the aim of satisfying system requirements, the RCS will select rich Internet application (RIA) as a user interface, Java as a back-end service and Secure Socket Layer Virtual Private Network (SSL VPN) for securable Internet communication

  14. Conceptual design of Remote Control System for EAST tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Sun, X.Y., E-mail: xysun@ipp.ac.cn; Wang, F.; Wang, Y.; Li, S.

    2014-05-15

    Highlights: • A new design conception for remote control for EAST tokamak is proposed. • Rich Internet application (RIA) was selected to implement the user interface. • Some security mechanism was used to fulfill security requirement. - Abstract: The international collaboration becomes popular in tokamak research like in many other fields of science, because the experiment facilities become larger and more expensive. The traditional On-site collaboration Model that has to spend much money and time on international travel is not fit for the more frequent international collaboration. The Remote Control System (RCS), as an extension of the Central Control System for the EAST tokamak, is designed to provide an efficient and economical way to international collaboration. As a remote user interface, the RCS must integrate with the Central Control System for EAST tokamak to perform discharge control function. This paper presents a design concept delineating a few key technical issues and addressing all significant details in the system architecture design. With the aim of satisfying system requirements, the RCS will select rich Internet application (RIA) as a user interface, Java as a back-end service and Secure Socket Layer Virtual Private Network (SSL VPN) for securable Internet communication.

  15. Central nervous system tumors

    International Nuclear Information System (INIS)

    Gavin, P.R.; Fike, J.R.; Hoopes, P.J.

    1995-01-01

    Central nervous system (CNS) tumors are relatively common in veterinary medicine, with most diagnoses occurring in the canine and feline species. Numerous tumor types from various cells or origins have been identified with the most common tumors being meningiomas and glial cell tumors. Radiation therapy is often used as an aid to control the clinical signs associated with these neoplasms. In general, these tumors have a very low metastatic potential, such that local control offers substantial benefit. Experience in veterinary radiation oncology would indicate that many patients benefit from radiation treatment. Current practice indicates the need for computed tomography or magnetic resonance imaging studies. These highly beneficial studies are used for diagnosis, treatment planning, and to monitor treatment response. Improvements in treatment planning and radiation delivered to the tumor, while sparing the normal tissues, should improve local control and decrease potential radiation related problems to the CNS. When possible, multiple fractions of 3 Gy or less should be used. The tolerance dose to the normal tissue with this fractionation schedule is 50 to 55 Gy. The most common and serious complications of radiation for CNS tumors is delayed radiation myelopathy and necrosis. Medical management of the patient during radiation therapy requires careful attention to anesthetic protocols, and medications to reduce intracranial pressure that is often elevated in these patients. Canine brain tumors have served as an experimental model to test numerous new treatments. Increased availability of advanced imaging modalities has spawned increased detection of these neoplasms. Early detection of these tumors with appropriate aggressive therapy should prove beneficial to many patients

  16. Central voice production and pathophysiology of spasmodic dysphonia.

    Science.gov (United States)

    Mor, Niv; Simonyan, Kristina; Blitzer, Andrew

    2018-01-01

    Our ability to speak is complex, and the role of the central nervous system in controlling speech production is often overlooked in the field of otolaryngology. In this brief review, we present an integrated overview of speech production with a focus on the role of central nervous system. The role of central control of voice production is then further discussed in relation to the potential pathophysiology of spasmodic dysphonia (SD). Peer-review articles on central laryngeal control and SD were identified from PUBMED search. Selected articles were augmented with designated relevant publications. Publications that discussed central and peripheral nervous system control of voice production and the central pathophysiology of laryngeal dystonia were chosen. Our ability to speak is regulated by specialized complex mechanisms coordinated by high-level cortical signaling, brainstem reflexes, peripheral nerves, muscles, and mucosal actions. Recent studies suggest that SD results from a primary central disturbance associated with dysfunction at our highest levels of central voice control. The efficacy of botulinum toxin in treating SD may not be limited solely to its local effect on laryngeal muscles and also may modulate the disorder at the level of the central nervous system. Future therapeutic options that target the central nervous system may help modulate the underlying disorder in SD and allow clinicians to better understand the principal pathophysiology. NA.Laryngoscope, 128:177-183, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  17. Intelligent Lighting Control System

    OpenAIRE

    García, Elena; Rodríguez González, Sara; de Paz Santana, Juan F.; Bajo Pérez, Javier

    2014-01-01

    This paper presents an adaptive architecture that allows centralized control of public lighting and intelligent management, in order to economise on lighting and maintain maximum comfort status of the illuminated areas. To carry out this management, architecture merges various techniques of artificial intelligence (AI) and statistics such as artificial neural networks (ANN), multi-agent systems (MAS), EM algorithm, methods based on ANOVA and a Service Oriented Aproach (SOA). It performs optim...

  18. Interactive robot control system and method of use

    Science.gov (United States)

    Sanders, Adam M. (Inventor); Reiland, Matthew J. (Inventor); Abdallah, Muhammad E. (Inventor); Linn, Douglas Martin (Inventor); Platt, Robert (Inventor)

    2012-01-01

    A robotic system includes a robot having joints, actuators, and sensors, and a distributed controller. The controller includes command-level controller, embedded joint-level controllers each controlling a respective joint, and a joint coordination-level controller coordinating motion of the joints. A central data library (CDL) centralizes all control and feedback data, and a user interface displays a status of each joint, actuator, and sensor using the CDL. A parameterized action sequence has a hierarchy of linked events, and allows the control data to be modified in real time. A method of controlling the robot includes transmitting control data through the various levels of the controller, routing all control and feedback data to the CDL, and displaying status and operation of the robot using the CDL. The parameterized action sequences are generated for execution by the robot, and a hierarchy of linked events is created within the sequence.

  19. KGS Based Control for Parking Brake Cable Manufacturing System

    OpenAIRE

    Geeta Khare; R.S. Prasad

    2011-01-01

    In today’s competitive production environment, process industries, demand a totally integrated control and optimization solution that can increase productivity, reliability and quality while minimizing cost. Automation is a step beyond mechanization. For automation of production plant either centralized or distributed control system are used. There are standardized approaches and standard hardware & software available worldwide as per the requirement. Investment in process control system is a...

  20. Multi-Agent System based Event-Triggered Hybrid Controls for High-Security Hybrid Energy Generation Systems

    DEFF Research Database (Denmark)

    Dou, Chun-Xia; Yue, Dong; Guerrero, Josep M.

    2017-01-01

    This paper proposes multi-agent system based event- triggered hybrid controls for guaranteeing energy supply of a hybrid energy generation system with high security. First, a mul-ti-agent system is constituted by an upper-level central coordi-nated control agent combined with several lower......-level unit agents. Each lower-level unit agent is responsible for dealing with internal switching control and distributed dynamic regula-tion for its unit system. The upper-level agent implements coor-dinated switching control to guarantee the power supply of over-all system with high security. The internal...

  1. A centralized storage system for the delivery of subcutaneous infusions.

    Science.gov (United States)

    Stuart, Peter; Lee, Jane; Arnold, Gill; Davis, Melanie

    Symptom control is an important part of maintaining a palliative patient's comfort and dignity, particularly in the end stages of their illness. Within the discipline of palliative care, the use of continuous subcutaneous syringe drivers is an important way of administering drugs at the end stages of a patient's illness to maintain symptom control. This study identified that ward staff had difficulty in obtaining the correct equipment, such as administration sets and Luer-lock syringes, leading to significant delays in patients being given drugs, affecting patient care and, when unable to obtain the correct equipment, the incorrect equipment was used. It was also identified that there was no consistent approach to the use or maintenance of syringe drivers, with a clear risk to patient safety. The study aim was to identify whether the introduction of a centralized storage system of set boxes containing all the relevant equipment would resolve these issues and improve patient care and safety. The audit showed that a centralized storage system enhanced practice by ensuring that there was a standardized approach to the initiation and care of syringe drivers, including equipment when used in the palliative care setting. The system also provided easy access to the correct equipment, reducing in the delay of commencing treatment, as well as the risk of any adverse events.

  2. The operation of the GANIL control system

    International Nuclear Information System (INIS)

    Prome, M.; David, L.; Lecorche, E.

    1984-06-01

    When the first GANIL beams were obtained the control system was operating in an elementary way; the system behaved almost like a huge multiplexer. Now a large number of programs have been written; they allow to take benefit of the full power of the computers; they help the operators for starting, tuning and monitoring the accelerator. The paper gives a general description of these programs which are executed on the central computer: it shows how the accelerator is controlled either directly or via dedicated microprocessors. Informations are also given on the alarm system

  3. Brain MRI screening showing evidences of early central nervous system involvement in patients with systemic sclerosis.

    Science.gov (United States)

    Mohammed, Reem Hamdy A; Sabry, Yousriah Y; Nasef, Amr A

    2011-05-01

    Systemic sclerosis is a multisystem autoimmune collagen disease where structural and functional abnormalities of small blood vessels prevail. Transient ischemic attacks, ischemic stroke, and hemorrhage have been reported as primary consequence of vascular central nervous system affection in systemic sclerosis. Magnetic resonance imaging is considered to be the most sensitive diagnostic technique for detecting symptomatic and asymptomatic lesions in the brain in cases of multifocal diseases. The objective of this study is to detect subclinical as well as clinically manifest cerebral vasculopathy in patients with systemic sclerosis using magnetic resonance imaging. As much as 30 female patients with systemic sclerosis aged 27-61 years old, with disease duration of 1-9 years and with no history of other systemic disease or cerebrovascular accidents, were enrolled. Age-matched female control group of 30 clinically normal subjects, underwent brain magnetic resonance examination. Central nervous system (CNS) involvement in the form of white matter hyperintense foci of variable sizes were found in significantly abundant forms in systemic sclerosis patients on magnetic resonance evaluation than in age-related control group, signifying a form of CNS vasculopathy. Such foci showed significant correlation to clinical features of organic CNS lesion including headaches, fainting attacks and organic depression as well as to the severity of peripheral vascular disease with insignificant correlation with disease duration. In conclusion, subclinical as well as clinically manifest CNS ischemic vasculopathy is not uncommon in systemic sclerosis patients and magnetic resonance imaging is considered a sensitive noninvasive screening tool for early detection of CNS involvement in patients with systemic sclerosis.

  4. Monitoring System with Two Central Facilities Protocol

    Directory of Open Access Journals (Sweden)

    Caesar Firdaus

    2017-03-01

    Full Text Available The security of data and information on government’s information system required proper way of defending against threat. Security aspect can be achieved by using cryptography algorithm, applying information hiding concept, and implementing security protocol. In this research, two central facilities protocol was implemented on Research and Development Center of Mineral and Coal Technology’s Cooperation Contract Monitoring System by utilizing AES and whitespace manipulation algorithm. Adjustment on the protocol by creating several rule of validation ID’s generation and checking processes could fulfill two of four cryptography objectives, consist of authentication and non-repudiation. The solid collaboration between central legitimization agency (CLA, central tabulating facility (CTF, and client is the main idea in two central facilities protocol. The utilization of AES algorithm could defend the data on transmission from man in the middle attack scenario. On the other hand, whitespace manipulation algorithm provided data integrity aspect of the document that is uploaded to the system itself. Both of the algorithm fulfill confidentiality, data integrity, and authentication.

  5. 21 CFR 882.5550 - Central nervous system fluid shunt and components.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

  6. An integrated computer control system for the ANU linac

    International Nuclear Information System (INIS)

    Davidson, P.M.; Foote, G.S.

    1996-01-01

    One facet of the installation of the superconducting linac at the ANU is the need for computer control of a variety of systems, such as beam transport, resonator RF, cryogenics and others. To accommodate this, a number of control interfaces (for example, analogue signals and RS232 serial lines) must be employed. Ideally, all of the systems should be able to be controlled from a central location, remote from the actual devices. To this end a system based around VAX computers and VME crates has been designed and is currently being developed and implemented. A VAXstation is used to issue control messages and perform high-level functions, while VME crates containing appropriate modules (primarily DACs, ADCs and digital I/O boards) control the devices. The controllers in the VME crates are AEON rtVAX modules running a real-time operating system. Communication with the VAXstation is via DECnet, on a private ethernet to allow communication rates unaffected by unrelated network activity and potentially increasing the security of the system by providing a possible network isolation point. Also on this ethernet are a number of terminal servers to control RS232 devices. A central database contains all device control and monitoring parameters. The main control process running on the VAXstation is responsible for maintaining the current values of the parameters in the database and for dispatching control messages to the appropriate VME crate or RS232 serial line

  7. Paracoccidioidomicose sistêmica com envolvimento do sistema nervoso central Systemic paracoccidioidomycosis with central nervous system involvement

    Directory of Open Access Journals (Sweden)

    Antônio Luiz Wiener Pureza Duarte

    1999-08-01

    Full Text Available É relatado o caso de um paciente portador de paracoccidioidomicose sistêmica, com comprometimento oral e ganglionar regional e posterior envolvimento pulmonar. O paciente, tratado com drogas específicas(anfotericina B, itraconazol, sulfametoxazol + trimetoprim e acompanhado durante seis anos, foi ao óbito com extenso comprometimento do sistema nervoso centralA clinical case of a patient bearing systemic paracoccidioidomycosis with regional ganglionic and oral exposure and later pulmonary envolvement is presented. The patient was treated with especific drugs (amphotericin B, itraconazole, sulfamethoxazole-trimethoprim and followed throughout a 6-year period and eventually died showing an extensive envolvement of the central nervous system.

  8. Central Accountability System (CLAS)

    International Nuclear Information System (INIS)

    Hairston, L.A.

    1991-01-01

    The Central Accountability System (CLAS) is a high level accountability system that consolidates data from the site's 39 material balance areas (MBA) for reporting to Westinghouse Savannah River Company (WSRC) management, Department of Energy (DOE) and the Nuclear Materials Management and Safeguards System (NMMSS) in Oak Ridge, TN. Development of the system began in 1989 and became operational in April, 1991. The CLAS system enhances data accuracy and accountability records, resulting in increased productivity and time and cost savings. This paper reports that the system is in compliance with DOE Orders and meets NMMSS reporting requirements. WSRC management is provided with the overall status of the site's nuclear material inventory. CLAS gives WSRC a leading edge in accounting technology and enhances good accounting practices

  9. Childhood Central Nervous System Atypical Teratoid/Rhabdoid Tumor Treatment

    Science.gov (United States)

    ... teratoid/rhabdoid tumor. There is no standard staging system for central nervous system atypical teratoid/rhabdoid tumor. The extent or spread ... different types of treatment for patients with central nervous system atypical teratoid/rhabdoid tumor. Different types of treatment ...

  10. Remote diagnosis system for control and instrumentation systems

    International Nuclear Information System (INIS)

    Ito, Tetsuo; Suzuki, Satoshi; Nagaoka, Yukio.

    1990-01-01

    Control and instrumentation (C and I) systems for nuclear power plants tend to consist of many distributed digital controllers connected with transmission networks. Important parts of the C and I systems are redundantly constructed so that the failure of a component does not readily have a critical effect on the plant operation. It is necessary, however, to localize the faulty component for establishing better availability and maintainability of the plant. To diagnose failure of the C and I systems effectively, a remote diagnosis system is required that diagnoses anomalies of their controllers remotely from a central control room and identifies the fault location. Various fault diagnosis methods that apply artificial intelligence have been proposed for electronic circuits. Their knowledge bases are classified into two categories. One is rule-based knowledge, describing relations between anomaly phenomena and causes. The other is structure-based knowledge, which represents the configuration and functions of diagnosed objects. Though the latter is more suitable for deep inference, it is difficult to use for describing the detailed structure of large-scaled digital C and I systems. Then, a fault diagnosis system was developed that uses both knowledge bases and offers substantial man/machine interface functions for practical use

  11. Central auditory processing and migraine: a controlled study.

    Science.gov (United States)

    Agessi, Larissa Mendonça; Villa, Thaís Rodrigues; Dias, Karin Ziliotto; Carvalho, Deusvenir de Souza; Pereira, Liliane Desgualdo

    2014-11-08

    This study aimed to verify and compare central auditory processing (CAP) performance in migraine with and without aura patients and healthy controls. Forty-one volunteers of both genders, aged between 18 and 40 years, diagnosed with migraine with and without aura by the criteria of "The International Classification of Headache Disorders" (ICDH-3 beta) and a control group of the same age range and with no headache history, were included. Gaps-in-noise (GIN), Duration Pattern test (DPT) and Dichotic Digits Test (DDT) tests were used to assess central auditory processing performance. The volunteers were divided into 3 groups: Migraine with aura (11), migraine without aura (15), and control group (15), matched by age and schooling. Subjects with aura and without aura performed significantly worse in GIN test for right ear (p = .006), for left ear (p = .005) and for DPT test (p UNIFESP.

  12. Design of embedded control system for high-power tetrode modulator

    International Nuclear Information System (INIS)

    Tu Rui; Yao Lieying; Xuan Weimin

    2010-01-01

    The design of embedded control system for the high-power tetrode modulator and its test results are given. This control system is a closed-loop feedback system based on the DSP and embedded into the high-voltage modulator. A new modified method of VF fiber transmission is used in the embedded control system. The new method improves the speed of the transmission of feedback system. The results of the experiment demonstrate that the embedded feedback control system greatly increases the response speed of the whole system and improves the performance of the high-power tetrode on the HL-2A tokamak. This embedded feedback control system greatly simplifies the complexity of the original centralized control system. The operation of the control system is reliable. (authors)

  13. A Novel Secondary Control for Microgrid Based on Synergetic Control of Multi-Agent System

    Directory of Open Access Journals (Sweden)

    Zhiwen Yu

    2016-03-01

    Full Text Available In power systems, the secondary control is a very useful way to restore the system frequency and voltage to the rated value. This paper tries to propose a secondary frequency and voltage control of islanded microgrids based on the distributed synergetic control of multi-agent systems. In the proposed control, since each distributed generation only requires its own information and that of the neighbors, the secondary control is fully distributed. The system is more reliable because the central controller and complex communication network are reduced in the distributed structure. Based on multi-agent systems, the dynamic model is established, and distributed synergetic control algorithms are given to design the secondary control of the islanded microgrid. Meanwhile, the system has globally asymptotic stability under the proposed control, which is proved by the direct Lyapunov method. Simulation results about a test microgrid are given to verify the effectiveness of the proposed control.

  14. Operating The Central Process Systems At Glenn Research Center

    Science.gov (United States)

    Weiler, Carly P.

    2004-01-01

    As a research facility, the Glenn Research Center (GRC) trusts and expects all the systems, controlling their facilities to run properly and efficiently in order for their research and operations to occur proficiently and on time. While there are many systems necessary for the operations at GRC, one of those most vital systems is the Central Process Systems (CPS). The CPS controls operations used by GRC's wind tunnels, propulsion systems lab, engine components research lab, and compressor, turbine and combustor test cells. Used widely throughout the lab, it operates equipment such as exhausters, chillers, cooling towers, compressors, dehydrators, and other such equipment. Through parameters such as pressure, temperature, speed, flow, etc., it performs its primary operations on the major systems of Electrical Dispatch (ED), Central Air Dispatch (CAD), Central Air Equipment Building (CAEB), and Engine Research Building (ERB). In order for the CPS to continue its operations at Glenn, a new contract must be awarded. Consequently, one of my primary responsibilities was assisting the Source Evaluation Board (SEB) with the process of awarding the recertification contract of the CPS. The job of the SEB was to evaluate the proposals of the contract bidders and then to present their findings to the Source Selecting Official (SSO). Before the evaluations began, the Center Director established the level of the competition. For this contract, the competition was limited to those companies classified as a small, disadvantaged business. After an industry briefing that explained to qualified companies the CPS and type of work required, each of the interested companies then submitted proposals addressing three components: Mission Suitability, Cost, and Past Performance. These proposals were based off the Statement of Work (SOW) written by the SEB. After companies submitted their proposals, the SEB reviewed all three components and then presented their results to the SSO. While the

  15. Hydrogels for central nervous system therapeutic strategies.

    Science.gov (United States)

    Russo, Teresa; Tunesi, Marta; Giordano, Carmen; Gloria, Antonio; Ambrosio, Luigi

    2015-12-01

    The central nervous system shows a limited regenerative capacity, and injuries or diseases, such as those in the spinal, brain and retina, are a great problem since current therapies seem to be unable to achieve good results in terms of significant functional recovery. Different promising therapies have been suggested, the aim being to restore at least some of the lost functions. The current review deals with the use of hydrogels in developing advanced devices for central nervous system therapeutic strategies. Several approaches, involving cell-based therapy, delivery of bioactive molecules and nanoparticle-based drug delivery, will be first reviewed. Finally, some examples of injectable hydrogels for the delivery of bioactive molecules in central nervous system will be reported, and the key features as well as the basic principles in designing multifunctional devices will be described. © IMechE 2015.

  16. BLED: a top-down approach to accelerator control system design

    International Nuclear Information System (INIS)

    Bobnar, J.; Zagar, K.

    2012-01-01

    In many existing controls projects the central database/inventory was introduced late in the project, usually to support installation or maintenance activities. Thus construction of this database was done in a bottom-up fashion by reverse engineering of the installation. However, there are several benefits if the central database is introduced early in the machine design, such as the ability to simulate the system as a whole without having all the IOCs in place, it can be used as an input to the installation/commissioning plan, or act as an enforcer of certain conventions and quality processes. Based on our experience with control systems, we have designed a central database BLED, which is used for storage of machine configuration and parameters as well as control system configuration, inventory, and cabling. The first implementation of BLED supports EPICS, meaning it is capable of storage and generation of EPICS templates and substitution files as well as archive, alarm and other configurations. With a goal in mind to provide functionality of several existing central databases (IRMIS, SNS db, DBSF etc.) a lot of effort has been made to design the database in a way to handle extremely large set-ups, consisting of millions of control system points. Furthermore, BLED also stores the lattice data, thus providing additional information (e.g. survey data) required by different engineering groups. The lattice import/export tools among others support MAD and TraceWin tools formats which are widely used in the machine design community. (author)

  17. Contemporary approaches to control system specification and design applied to KAON

    International Nuclear Information System (INIS)

    Ludgate, G.A.; Osberg, E.A.; Dohan, D.A.

    1991-05-01

    Large data acquisition and control systems have evolved from early centralized computer systems to become multi-processor, distributed systems. While the complexity of these systems has increased our ability to reliably manage their construction has not kept pace. Structured analysis and real-time structured analysis have been used successfully to specify systems but, from a project management viewpoint, both lead to different classes of problems during implementation and maintenance. The KAON Factory central control system study employed a uniform approach to requirements analysis and architectural design. The methodology was based on well established object-oriented principles and was free of the problems inherent in the older methodologies. The methodology is presently being used to implement two systems at TRIUMF. (Author) 12 refs

  18. Agile Design of Sewer System Control

    NARCIS (Netherlands)

    Van Nooijen, R.P.; Kolechkina, A.G.; Van Leeuwen, P.E.R.M.; Van Velzen, E.

    2011-01-01

    We describe the first part of an attempt to include stakeholder participation in the design of a central automatic controller for a sewer system in a small pilot project (five subcatchments) and present lessons learned so far. The pilot is part of a project aimed at the improvement of water quality

  19. EMPLACEMENT DRIFT ISOLATION DOOR CONTROL SYSTEM

    International Nuclear Information System (INIS)

    N.T. Raczka

    1998-01-01

    The purpose of this analysis is to review and refine key design concepts related to the control system presently under consideration for remotely operating the emplacement drift isolation doors at the potential subsurface nuclear waste repository at Yucca Mountain. This analysis will discuss the key design concepts of the control system that may be utilized for remotely monitoring, opening, and closing the emplacement drift isolation doors. The scope and primary objectives of this analysis are to: (1) Discuss the purpose and function of the isolation doors (Presented in Section 7.1). (2) Review the construction of the isolation door and other physical characteristics of the doors that the control system will interface with (Presented in Section 7.2). (3) Discuss monitoring and controlling the operation of the isolation doors with a digital control system (either a Programmable Logic Controller (PLC) system or a Distributed Control System (DCS)) (Presented in Section 7.3). (4) Discuss how all isolation doors can be monitored and controlled from a subsurface central control center (Presented in Section 7.4). This analysis will focus on the development of input/output (I/O) counts including the types of I/O, redundancy and fault tolerance considerations, and processor requirements for the isolation door control system. Attention will be placed on operability, maintainability, and reliability issues for the system operating in the subsurface environment with exposure to high temperatures and radiation

  20. Encyclopedia of systems and control

    CERN Document Server

    Samad, Tariq

    2015-01-01

    The Encyclopedia of Systems and Control collects a broad range of short expository articles that describe the current state of the art in the central topics of control and systems engineering as well as in many of the related fields in which control is an enabling technology. The editors have assembled the most comprehensive reference possible, and this has been greatly facilitated by the publisher’s commitment continuously to publish updates to the articles as they become available in the future. Although control engineering is now a mature discipline, it remains an area in which there is a great deal of research activity, and as new developments in both theory and applications become available, they will be included in the online version of the encyclopedia. A carefully chosen team of leading authorities in the field has written the well over 200 articles that comprise the work. The topics range from basic principles of feedback in servomechanisms to advanced topics such as the control of Boolean networks...

  1. Centralized operation and monitoring system for nuclear power plants

    International Nuclear Information System (INIS)

    Kudo, Mitsuru; Sato, Hideyuki; Murata, Fumio

    1988-01-01

    According to the prospect of long term energy demand, in 2000, the nuclear power generation facilities in Japan are expected to take 15.9% of the total energy demand. From this fact, it is an important subject to supply nuclear power more stably, and in the field of instrumentation and control, many researches and developments and the incessant effort of improvement have been continued. In the central operation and monitoring system which is the center of the stable operation of nuclear power plants, the man-machine technology aiding operators by electronic and computer application technologies has been positively developed and applied. It is considered that hereafter, for the purpose of rationally heightening the operation reliability of the plants, the high quality man-machine system freely using the most advanced technologies such as high reliability digital technology, optical information transmission, knowledge engineering and so on is developed and applied. The technical trend of operation and monitoring system, the concept of heightening operation and monitoring capability, the upgrading of operation and monitoring system, and the latest operation, monitoring and control systems for nuclear power plants and waste treatment facilities are described. (K.I.)

  2. Central nervous system affecting drugs and road traffic accidents ...

    African Journals Online (AJOL)

    Central nervous system affecting drugs and road traffic accidents among commercial motorcyclists. ... including driving under the influence of drugs that affect the central nervous system (CNS). ... Keywords: Brain, influence, riders, substances ...

  3. Central nervous system tumors

    International Nuclear Information System (INIS)

    Curran, W.J. Jr.

    1991-01-01

    Intrinsic tumors of the central nervous system (CNS) pose a particularly challenging problem to practicing oncologists. These tumors rarely metastasize outside the CNS, yet even histologically benign tumors can be life-threatening due to their local invasiveness and strategic location. The surrounding normal tissues of the nervous system is often incapable of full functional regeneration, therefore prohibiting aggressive attempts to use either complete surgical resection or high doses of irradiation. Despite these limitations, notable achievements have recently been recorded in the management of these tumors

  4. Remote device control and monitor system for the LHD deuterium experiments

    Energy Technology Data Exchange (ETDEWEB)

    Nakanishi, Hideya, E-mail: nakanisi@nifs.ac.jp [National Institute for Fusion Science (NIFS), Toki, Gifu 509-5292 (Japan); Dept. Fusion Science, SOKENDAI (The Graduate University for Advanced Studies), Toki, Gifu 509-5292 (Japan); Ohsuna, Masaki; Ito, Tatsuki; Nonomura, Miki; Imazu, Setsuo; Emoto, Masahiko; Iwata, Chie; Yoshida, Masanobu; Yokota, Mitsuhiro; Maeno, Hiroya; Aoyagi, Miwa; Ogawa, Hideki; Nakamura, Osamu; Morita, Yoshitaka; Inoue, Tomoyuki; Watanabe, Kiyomasa [National Institute for Fusion Science (NIFS), Toki, Gifu 509-5292 (Japan); Ida, Katsumi; Ishiguro, Seiji; Kaneko, Osamu [National Institute for Fusion Science (NIFS), Toki, Gifu 509-5292 (Japan); Dept. Fusion Science, SOKENDAI (The Graduate University for Advanced Studies), Toki, Gifu 509-5292 (Japan)

    2016-11-15

    Highlights: • Device remote control will be significant for the LHD deuterium experiments. • A central management GUI to control the power distribution for devices. • For safety, power management is separated from operational commanding. • Wi-Fi was tested and found to be not reliable with fusion plasmas. - Abstract: Upon beginning the LHD deuterium experiment, the opportunity for maintenance work in the torus hall will be conspicuously reduced such that all instruments must be controlled remotely. The LHD data acquisition (DAQ) and archiving system have been using about 110 DAQ front-end, and the DAQ central control and monitor system has been implemented for their remote management. This system is based on the “multi-agent” model whose communication protocol has been unified. Since DAQ front-end electronics would suffer from the “single-event effect” (SEE) of D-D neutrons, software-based remote operation might become ineffective, and then securely intercepting or recycling the electrical power of the device would be indispensable for recovering from a non-responding fault condition. In this study, a centralized control and monitor system has been developed for a number of power distribution units (PDUs). This system adopts the plug-in structure in which the plug-in modules can absorb the differences among the commercial products of numerous vendors. The combination of the above-mentioned functionalities has led to realizing the flexible and highly reliable remote control infrastructure for the plasma diagnostics and the device management in LHD.

  5. A Two-Level Optimal Scheduling Strategy for Central Air-Conditioners Based on Metal Model with Comprehensive State-Queueing Control Models

    Directory of Open Access Journals (Sweden)

    Yebai Qi

    2017-12-01

    Full Text Available Unlike some thermostatically controlled appliances (TCAs with small capacities, Central Air-conditioner (CAC has huge potential for demand response because of its large capacity. This paper presents a new CAC control strategy under multiple constraints. The CAC is modeled by three main modules: CAC central unit, water pumps, and temperature simulation of terminal users. The CAC’s power consumption is mainly determined by users’ load ratio. As the information and communication system have become the central nervous system of the smart grid, big data analysis is of great significance. Assuming that reliable two-way communication systems are preset, an integrated parameter priority list (IPPL control strategy is used to control and monitor CAC. A new intelligent algorithm, Space Exploration and Unimodal Region Elimination (SEUMRE algorithm, is introduced for solving the optimization problem of demand response targets generation under multiple constraints with the help of big data analysis. In this paper, influences and constrain factors, such as price and users’ comfortable levels are taken into account to satisfy the need of actual situation. Simulation results show that the proposed approach, when comparing with other typical optimization algorithms, yields better performances and efficiency.

  6. Transmission Reinforcements in the Central American Regional Power System

    Energy Technology Data Exchange (ETDEWEB)

    Elizondo, Marcelo A.; Vallem, Mallikarjuna R.; Samaan, Nader A.; Makarov, Yuri V.; Vyakaranam, Bharat; Nguyen, Tony B.; Munoz, Christian; Herrera, Ricardo; Midence, Diego; Shpitsberg, Anna

    2016-07-25

    The Central American regional interconnected power system (SER) connects the countries members of the Central American regional electricity market (MER): Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica, and Panama. The SER was a result of a long term regional effort, and was initially conceived to transfer 300 MW between countries. However, the current transfer limits between countries range from 70 MW to 300 MW. Regional entities, like CRIE (Regional Commission of Electrical Interconnection), EOR (Central American Regional System Operator), and CDMER (Board of Directors of the Central American Market) are working on coordinating the national transmission expansion plans with regional transmission planning efforts. This paper presents experience in Central America region to recommend transmission reinforcements to achieve 300 MW transfer capacity between any pair of member countries of the Central American regional electricity market (MER). This paper also provides a methodology for technical analysis and for coordination among the regional and national entities. This methodology is unique for transmission systems of these characteristics.

  7. Central nervous system depressant activityof Leonurus sibiricus ...

    African Journals Online (AJOL)

    The methanol extract of aerial parts of Leonurus sibiricus was shown to possess central nervous system depressant action by significantly decreased the time of onset of sleep and potentiated the pentobarbital induced sleeping time in mice. Keywords: Leonurus sibiricus, labiatae, central nervous depressant, sedation

  8. Interferons in the central nervous system

    DEFF Research Database (Denmark)

    Owens, Trevor; Khorooshi, Reza M. H.; Wlodarczyk, Agnieszka

    2014-01-01

    Interferons (IFNs) are implicated as an important component of the innate immune system influencing viral infections, inflammation, and immune surveillance. We review here the complex biological activity of IFNs in the central nervous system (CNS) and associated glial–immune interactions...

  9. Efficiency Analysis of Independent and Centralized Heating Systems for Residential Buildings in Northern Italy

    Directory of Open Access Journals (Sweden)

    Fabio Rinaldi

    2011-11-01

    Full Text Available The primary energy consumption in residential buildings is determined by the envelope thermal characteristics, air change, outside climatic data, users’ behaviour and the adopted heating system and its control. The new Italian regulations strongly suggest the installation of centralized boilers in renovated buildings with more than four apartments. This work aims to investigate the differences in primary energy consumption and efficiency among several independent and centralized heating systems installed in Northern Italy. The analysis is carried out through the following approach: firstly building heating loads are evaluated using the software TRNSYS® and, then, heating system performances are estimated through a simplified model based on the European Standard EN 15316. Several heating systems have been analyzed, evaluating: independent and centralized configurations, condensing and traditional boilers, radiator and radiant floor emitters and solar plant integration. The heating systems are applied to four buildings dating back to 2010, 2006, 1960s and 1930s. All the combinations of heating systems and buildings are analyzed in detail, evaluating efficiency and primary energy consumption. In most of the cases the choice between centralized and independent heating systems has minor effects on primary energy consumption, less than 3%: the introduction of condensing technology and the integration with solar heating plant can reduce energy consumption by 11% and 29%, respectively.

  10. Optimage central organised image quality control including statistics and reporting

    International Nuclear Information System (INIS)

    Jahnen, A.; Schilz, C.; Shannoun, F.; Schreiner, A.; Hermen, J.; Moll, C.

    2008-01-01

    Quality control of medical imaging systems is performed using dedicated phantoms. As the imaging systems are more and more digital, adequate image processing methods might help to save evaluation time and to receive objective results. The developed software package OPTIMAGE is focusing on this with a central approach: On one hand, OPTIMAGE provides a framework, which includes functions like database integration, DICOM data sources, multilingual user interface and image processing functionality. On the other hand, the test methods are implemented using modules which are able to process the images automatically for the common imaging systems. The integration of statistics and reporting into this environment is paramount: This is the only way to provide these functions in an interactive, user-friendly way. These features enable the users to discover degradation in performance quickly and document performed measurements easily. (authors)

  11. Focal lesions in the central nervous system

    International Nuclear Information System (INIS)

    Fabrikant, J.I.; Budinger, T.F.; Tobias, C.A.; Born, J.L.

    1980-01-01

    This report reviews the animal and human studies currently in progress at LBL with heavy-ion beams to induce focal lesions in the central nervous system, and discusses the potential future prospects of fundamental and applied brain research with heavy-ion beams. Methods are being developed for producing discrete focal lesions in the central nervous system using the Bragg ionization peak to investigate nerve pathways and neuroendocrine responses, and for treating pathological disorders of the brain

  12. Automated entry control system for nuclear facilities

    International Nuclear Information System (INIS)

    Ream, W.K.; Espinoza, J.

    1985-01-01

    An entry control system to automatically control access to nuclear facilities is described. The design uses a centrally located console, integrated into the regular security system, to monitor the computer-controlled passage into and out of sensitive areas. Four types of entry control points are used: an unmanned enclosed portal with metal and SNM detectors for contraband detection with positive personnel identification, a bypass portal for contraband search after a contraband alarm in a regular portal also with positive personnel identification, a single door entry point with positive personnel identification, and a single door entry point with only a magnetic card-type identification. Security force action is required only as a response to an alarm. The integration of the entry control function into the security system computer is also described. The interface between the entry control system and the monitoring security personnel utilizing a color graphics display with touch screen input is emphasized. 2 refs., 7 figs

  13. Central Nervous System Infections in Denmark

    Science.gov (United States)

    2018-02-04

    Central Nervous System Infections; Bacterial Meningitis; Viral Meningitis; Aseptic Meningitis; Encephalitis; Brain Abscess; Neuroborreliosis; Neurosyphilis; Lyme Disease; Tertiary Syphilis; Cerebral Abscess; Meningitis

  14. The influence of diabetic peripheral neuropathy on local postural muscle and central sensory feedback balance control.

    Science.gov (United States)

    Toosizadeh, Nima; Mohler, Jane; Armstrong, David G; Talal, Talal K; Najafi, Bijan

    2015-01-01

    Poor balance control and increased fall risk have been reported in people with diabetic peripheral neuropathy (DPN). Traditional body sway measures are unable to describe underlying postural control mechanism. In the current study, we used stabilogram diffusion analysis to examine the mechanism under which balance is altered in DPN patients under local-control (postural muscle control) and central-control (postural control using sensory cueing). DPN patients and healthy age-matched adults over 55 years performed two 15-second Romberg balance trials. Center of gravity sway was measured using a motion tracker system based on wearable inertial sensors, and used to derive body sway and local/central control balance parameters. Eighteen DPN patients (age = 65.4±7.6 years; BMI = 29.3±5.3 kg/m2) and 18 age-matched healthy controls (age = 69.8±2.9; BMI = 27.0±4.1 kg/m2) with no major mobility disorder were recruited. The rate of sway within local-control was significantly higher in the DPN group by 49% (healthy local-controlslope = 1.23±1.06×10-2 cm2/sec, Pcontrol balance behavior in DPN patients. Unlike local-control, the rate of sway within central-control was 60% smaller in the DPN group (healthy central-controlslope-Log = 0.39±0.23, Pcontrol rate of sway with neuropathy severity (rPearson = 0.65-085, Pcontrols. However, as soon as they perceived the magnitude of sway using sensory feedback, they chose a high rigid postural control strategy, probably due to high concerns for fall, which may increase the energy cost during extended period of standing; the adaptation mechanism using sensory feedback depends on the level of neuropathy and the history of diabetes.

  15. APE (state-oriented approach) centralized control procedures; Procedures de conduite APE (Approche Par Etats)

    Energy Technology Data Exchange (ETDEWEB)

    Astier, D. [FRAMATOME ANP, 92 - Paris-La-Defence (France); Depont, G. [Electricite de France (EDF/DPN), 93 - Saint-Denis (France); Van Dermarliere, Y. [Electricite de France (EDF/SEPTEN), 69 - Villeurbanne (France)

    2004-07-01

    This article presents the progressive implementation of the state-oriented approach (APE) for centralized control procedures in French nuclear power plants. The implementation began in the years 1982-83 and it concerned only the circuits involved in engineered safeguard systems such IS (safety injection), EAS (containment spray system) and GMPP (reactor coolant pump set). In 2003 the last PWR unit switched from the event oriented approach to APE for post-accidental situations.

  16. A front-end system for industrial type controls at the SSC

    International Nuclear Information System (INIS)

    Haenni, D.R.

    1992-01-01

    The SSC control system is tasked with coordinating the operation of many different accelerator subsystems, a number of which use industrial type process controls. The design of a high-performance control system front end is presented which serves both as a data concentrator and a distributed process controller. In addition it provides strong support for a centralized control system architecture, allows for regional control systems, and simplifies the construction of inter-subsystem controls. An implementation of this design will be discussed which uses STD-Bus for accelerator hardware interfacing, a time domain multiplexing (TDM) communications transport system, and a modified reflective memory interface to the rest of the control system. (author)

  17. Fixed Point Learning Based Intelligent Traffic Control System

    Science.gov (United States)

    Zongyao, Wang; Cong, Sui; Cheng, Shao

    2017-10-01

    Fixed point learning has become an important tool to analyse large scale distributed system such as urban traffic network. This paper presents a fixed point learning based intelligence traffic network control system. The system applies convergence property of fixed point theorem to optimize the traffic flow density. The intelligence traffic control system achieves maximum road resources usage by averaging traffic flow density among the traffic network. The intelligence traffic network control system is built based on decentralized structure and intelligence cooperation. No central control is needed to manage the system. The proposed system is simple, effective and feasible for practical use. The performance of the system is tested via theoretical proof and simulations. The results demonstrate that the system can effectively solve the traffic congestion problem and increase the vehicles average speed. It also proves that the system is flexible, reliable and feasible for practical use.

  18. Statin therapy inhibits remyelination in the central nervous system

    DEFF Research Database (Denmark)

    Miron, Veronique E; Zehntner, Simone P; Kuhlmann, Tanja

    2009-01-01

    Remyelination of lesions in the central nervous system contributes to neural repair following clinical relapses in multiple sclerosis. Remyelination is initiated by recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) into myelinating oligodendrocytes. Simvastatin, a blood...... that OPCs were maintained in an immature state (Olig2(strong)/Nkx2.2(weak)). NogoA+ oligodendrocyte numbers were decreased during all simvastatin treatment regimens. Our findings suggest that simvastatin inhibits central nervous system remyelination by blocking progenitor differentiation, indicating...... the need to monitor effects of systemic immunotherapies that can access the central nervous system on brain tissue-repair processes....

  19. Load Distribution of Semi-Central Evaporative Cooling Air-Conditioning System Based on the TRNSYS Platform

    Directory of Open Access Journals (Sweden)

    Ji Li

    2018-05-01

    Full Text Available Evaporative cooling is a green, energy-efficient cooling technology adopted in hot and dry regions, which has wider application in the field of air-conditioning systems. Outdoor meteorological parameters have a great influence on the operation mode and control strategy of evaporative cooling air-conditioning systems, and the system load distribution and system configuration will be affected. This paper aims at investigating the load distribution of semi-central evaporative cooling air-conditioning systems under the condition of hourly outdoor meteorological parameters. Firstly, this paper introduced the design partition, operation mode, controlling strategy and load distribution method on semi-central evaporative cooling air-conditioning system. Then, taking an office building in Lanzhou (China as an example, the evaporative cooling air-conditioning system was divided into five regions and the load distribution was simulated by TRNSYS (The Transient Energy System Simulation Tool under the condition of hourly outdoor meteorological parameters. Finally, the results have shown that the evaporative cooling air-conditioning system can provide 25.46% of the building loads, which was of great significance to reduce the energy consumption of air-conditioning system.

  20. The Fermilab Accelerator control system

    Science.gov (United States)

    Bogert, Dixon

    1986-06-01

    With the advent of the Tevatron, considerable upgrades have been made to the controls of all the Fermilab Accelerators. The current system is based on making as large an amount of data as possible available to many operators or end-users. Specifically there are about 100 000 separate readings, settings, and status and control registers in the various machines, all of which can be accessed by seventeen consoles, some in the Main Control Room and others distributed throughout the complex. A "Host" computer network of approximately eighteen PDP-11/34's, seven PDP-11/44's, and three VAX-11/785's supports a distributed data acquisition system including Lockheed MAC-16's left from the original Main Ring and Booster instrumentation and upwards of 1000 Z80, Z8002, and M68000 microprocessors in dozens of configurations. Interaction of the various parts of the system is via a central data base stored on the disk of one of the VAXes. The primary computer-hardware communication is via CAMAC for the new Tevatron and Antiproton Source; certain subsystems, among them vacuum, refrigeration, and quench protection, reside in the distributed microprocessors and communicate via GAS, an in-house protocol. An important hardware feature is an accurate clock system making a large number of encoded "events" in the accelerator supercycle available for both hardware modules and computers. System software features include the ability to save the current state of the machine or any subsystem and later restore it or compare it with the state at another time, a general logging facility to keep track of specific variables over long periods of time, detection of "exception conditions" and the posting of alarms, and a central filesharing capability in which files on VAX disks are available for access by any of the "Host" processors.

  1. The Fermilab accelerator control system

    International Nuclear Information System (INIS)

    Bogert, D.

    1986-01-01

    With the advent of the Tevatron, considerable upgrades have been made to the controls of all the Fermilab Accelerators. The current system is based on making as large an amount of data as possible available to many operators or end-users. Specifically there are about 100000 separate readings, settings, and status and control registers in the various machines, all of which can be accessed by seventeen consoles, some in the Main Control Room and others distributed throughout the complex. A ''Host'' computer network of approximately eighteen PDP-11/34's, seven PDP-11/44's, and three VAX-11/785's supports a distributed data acquisition system including Lockheed MAC-16's left from the original Main Ring and Booster instrumentation and upwards of 1000 Z80, Z8002, and M68000 microprocessors in dozens of configurations. Interaction of the various parts of the system is via a central data base stored on the disk of one of the VAXes. The primary computer-hardware communication is via CAMAC for the new Tevatron and Antiproton Source; certain subsystems, among them vacuum, refrigeration and quench protection, reside in the distributed microprocessors and communicate via GAS, an in-house protocol. An important hardware feature is an accurate clock system making a large number of encoded ''events'' in the accelerator supercycle available for both hardware modules and computers. System software features include the ability to save the current state of the machine or any subsystem and later restore it or compare it with the state at another time, a general logging facility to keep track of specific variables over long periods of time, detection of 'exception conditions' and the posting of alarms, and a central filesharing capability in which files on VAX disks are available for access by any of the ''Host'' processors. (orig.)

  2. Separate individual control systems come together at EP2

    International Nuclear Information System (INIS)

    Podmore, A.

    1991-01-01

    At BNFL's EP2 radioactive waste encapsulation plant in the UK, eight area supervisory control and data acquisition systems (SCADAs) and one central SCADA are being installed to provide computer-controlled processing of waste drums. The individual systems are all autonomous, minimizing the effect they have on other areas of the process. At the same time, they are part of an integrated system which provides effective communication between the various areas. (author)

  3. Role Based Access Control system in the ATLAS experiment

    International Nuclear Information System (INIS)

    Valsan, M L; Dumitru, I; Darlea, G L; Bujor, F; Dobson, M; Miotto, G Lehmann; Schlenker, S; Avolio, G; Scannicchio, D A; Filimonov, V; Khomoutnikov, V; Zaytsev, A S; Korol, A A; Bogdantchikov, A; Caramarcu, C; Ballestrero, S; Twomey, M

    2011-01-01

    The complexity of the ATLAS experiment motivated the deployment of an integrated Access Control System in order to guarantee safe and optimal access for a large number of users to the various software and hardware resources. Such an integrated system was foreseen since the design of the infrastructure and is now central to the operations model. In order to cope with the ever growing needs of restricting access to all resources used within the experiment, the Roles Based Access Control (RBAC) previously developed has been extended and improved. The paper starts with a short presentation of the RBAC design, implementation and the changes made to the system to allow the management and usage of roles to control access to the vast and diverse set of resources. The RBAC implementation uses a directory service based on Lightweight Directory Access Protocol to store the users (∼3000), roles (∼320), groups (∼80) and access policies. The information is kept in sync with various other databases and directory services: human resources, central CERN IT, CERN Active Directory and the Access Control Database used by DCS. The paper concludes with a detailed description of the integration across all areas of the system.

  4. Structural and functional features of central nervous system lymphatic vessels.

    Science.gov (United States)

    Louveau, Antoine; Smirnov, Igor; Keyes, Timothy J; Eccles, Jacob D; Rouhani, Sherin J; Peske, J David; Derecki, Noel C; Castle, David; Mandell, James W; Lee, Kevin S; Harris, Tajie H; Kipnis, Jonathan

    2015-07-16

    One of the characteristics of the central nervous system is the lack of a classical lymphatic drainage system. Although it is now accepted that the central nervous system undergoes constant immune surveillance that takes place within the meningeal compartment, the mechanisms governing the entrance and exit of immune cells from the central nervous system remain poorly understood. In searching for T-cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the cerebrospinal fluid, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the central nervous system. The discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

  5. Centralized mission planning and scheduling system for the Landsat Data Continuity Mission

    Science.gov (United States)

    Kavelaars, Alicia; Barnoy, Assaf M.; Gregory, Shawna; Garcia, Gonzalo; Talon, Cesar; Greer, Gregory; Williams, Jason; Dulski, Vicki

    2014-01-01

    Satellites in Low Earth Orbit provide missions with closer range for studying aspects such as geography and topography, but often require efficient utilization of space and ground assets. Optimizing schedules for these satellites amounts to a complex planning puzzle since it requires operators to face issues such as discontinuous ground contacts, limited onboard memory storage, constrained downlink margin, and shared ground antenna resources. To solve this issue for the Landsat Data Continuity Mission (LDCM, Landsat 8), all the scheduling exchanges for science data request, ground/space station contact, and spacecraft maintenance and control will be coordinated through a centralized Mission Planning and Scheduling (MPS) engine, based upon GMV’s scheduling system flexplan9 . The synchronization between all operational functions must be strictly maintained to ensure efficient mission utilization of ground and spacecraft activities while working within the bounds of the space and ground resources, such as Solid State Recorder (SSR) and available antennas. This paper outlines the functionalities that the centralized planning and scheduling system has in its operational control and management of the Landsat 8 spacecraft.

  6. How to implement a quantum algorithm on a large number of qubits by controlling one central qubit

    Science.gov (United States)

    Zagoskin, Alexander; Ashhab, Sahel; Johansson, J. R.; Nori, Franco

    2010-03-01

    It is desirable to minimize the number of control parameters needed to perform a quantum algorithm. We show that, under certain conditions, an entire quantum algorithm can be efficiently implemented by controlling a single central qubit in a quantum computer. We also show that the different system parameters do not need to be designed accurately during fabrication. They can be determined through the response of the central qubit to external driving. Our proposal is well suited for hybrid architectures that combine microscopic and macroscopic qubits. More details can be found in: A.M. Zagoskin, S. Ashhab, J.R. Johansson, F. Nori, Quantum two-level systems in Josephson junctions as naturally formed qubits, Phys. Rev. Lett. 97, 077001 (2006); and S. Ashhab, J.R. Johansson, F. Nori, Rabi oscillations in a qubit coupled to a quantum two-level system, New J. Phys. 8, 103 (2006).

  7. The influence of diabetic peripheral neuropathy on local postural muscle and central sensory feedback balance control.

    Directory of Open Access Journals (Sweden)

    Nima Toosizadeh

    Full Text Available Poor balance control and increased fall risk have been reported in people with diabetic peripheral neuropathy (DPN. Traditional body sway measures are unable to describe underlying postural control mechanism. In the current study, we used stabilogram diffusion analysis to examine the mechanism under which balance is altered in DPN patients under local-control (postural muscle control and central-control (postural control using sensory cueing. DPN patients and healthy age-matched adults over 55 years performed two 15-second Romberg balance trials. Center of gravity sway was measured using a motion tracker system based on wearable inertial sensors, and used to derive body sway and local/central control balance parameters. Eighteen DPN patients (age = 65.4±7.6 years; BMI = 29.3±5.3 kg/m2 and 18 age-matched healthy controls (age = 69.8±2.9; BMI = 27.0±4.1 kg/m2 with no major mobility disorder were recruited. The rate of sway within local-control was significantly higher in the DPN group by 49% (healthy local-controlslope = 1.23±1.06×10-2 cm2/sec, P<0.01, which suggests a compromised local-control balance behavior in DPN patients. Unlike local-control, the rate of sway within central-control was 60% smaller in the DPN group (healthy central-controlslope-Log = 0.39±0.23, P<0.02, which suggests an adaptation mechanism to reduce the overall body sway in DPN patients. Interestingly, significant negative correlations were observed between central-control rate of sway with neuropathy severity (rPearson = 0.65-085, P<0.05 and the history of diabetes (rPearson = 0.58-071, P<0.05. Results suggest that in the lack of sensory feedback cueing, DPN participants were highly unstable compared to controls. However, as soon as they perceived the magnitude of sway using sensory feedback, they chose a high rigid postural control strategy, probably due to high concerns for fall, which may increase the energy cost during extended period of standing; the adaptation

  8. Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity.

    Science.gov (United States)

    Corcoran, Andrea E; Richerson, George B; Harris, Michael B

    2015-07-01

    Serotonin (5-HT)-synthesizing neurons of the medullary raphe are putative central chemoreceptors, proposed to be one of potentially multiple brain stem chemosensitive cell types and loci interacting to produce the respiratory chemoreflex. Hypocretin-synthesizing neurons of the lateral hypothalamus are important contributors to arousal state, thermoregulation, and feeding behavior and are also reportedly involved in the hypercapnic ventilatory response. Recently, a functional interaction was found between the hypocretin system and 5-HT neurons of the dorsal raphe. The validity and potential significance of hypocretin modulation of medullary raphe 5-HT neurons, however, is unknown. As such, the purpose of this study was to explore functional interactions between the hypocretin system and 5-HT system of the medullary raphe on baseline respiratory output and central chemosensitivity. To explore such interactions, we used the neonatal in vitro medullary slice preparation derived from wild-type (WT) mice (normal 5-HT function) and a knockout strain lacking all central 5-HT neurons (Lmx1b(f/f/p) mice). We examined effects of acidosis, hypocretin-1, a hypocretin receptor antagonist (SB-408124), and the effect of the antagonist on the response to acidosis. We confirmed the critical role of 5-HT neurons in central chemosensitivity given that the increased hypoglossal burst frequency with acidosis, characteristic of WT mice, was absent in preparations derived from Lmx1b(f/f/p) mice. We also found that hypocretin facilitated baseline neural ventilatory output in part through 5-HT neurons. Although the impact of hypocretin on 5-HT neuronal sensitivity to acidosis is still unclear, hypocretins did appear to mediate the burst duration response to acidosis via serotonergic mechanisms.

  9. Representações gustativas no córtex humano, e o controle central do apetite Taste representation in the human cortex and the central control of appetite

    Directory of Open Access Journals (Sweden)

    Ivan E de Araújo

    2003-12-01

    Full Text Available Tem sido estabelecido que o controle da ingestão de nutrientes e o decorrente estado de equilíbrio homeostático dependem de uma série de sinais periféricos que atuam diretamente sobre o sistema nervoso central, levando a respostas adaptativas apropriadas. Entretanto, em humanos, a crescente incidência de patologias produzidas em grande medida por distúrbios da preferência alimentar, tais como obesidade e anorexia, implica no envolvimento do córtex no controle da ingestão de alimentos. Estudos recentes fazendo uso da neuroimagem funcional em voluntários humanos revelam que o processamento central da informação gustativa é implementado em humanos em áreas análogas a de outros primatas. As áreas corticais gustativas primárias, localizadas no complexo ínsulo-opercular, respondem eficientemente durante a decodificação de estímulos externos através do isolamento dos sinais que codificam o estado fisiológico do organismo. As áreas específicas do córtex pré-frontal em sua parte ventro-média parecem, por sua vez, integrar informações acerca dos aspectos sensoriais dos estímulos com os sinais de origem periférica que refletem o estado homeoestático do organismo.The control of food intake and the mechanisms of energy homeostasis are now known to depend on a series of peripheral signals that act directly on the central nervous system leading to appropriate adaptive responses. However, in humans, the increasing occurrence of associated pathologies due to abnormal food-intake preferences such as obesity and anorexia implies that food intake control depend also on cortical processing. Recent functional neuroimaging studies on human volunteers reveal that the central processing of gustatory information in humans is performed in similar areas to those of other primates, with primary gustatory cortical areas in the frontal operculum/anterior insula complex responding efficiently to stimulus decoding by isolating peripheral

  10. Dependable control systems with Internet of Things.

    Science.gov (United States)

    Tran, Tri; Ha, Q P

    2015-11-01

    This paper presents an Internet of Things (IoT)-enabled dependable control system (DepCS) for continuous processes. In a DepCS, an actuator and a transmitter form a regulatory control loop. Each processor inside such actuator and transmitter is designed as a computational platform implementing the feedback control algorithm. The connections between actuators and transmitters via IoT create a reliable backbone for a DepCS. The centralized input-output marshaling system is not required in DepCSs. A state feedback control synthesis method for DepCS applying the self-recovery constraint is presented in the second part of the paper. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  11. A novel system architecture for the national integration of electronic health records: a semi-centralized approach.

    Science.gov (United States)

    AlJarullah, Asma; El-Masri, Samir

    2013-08-01

    The goal of a national electronic health records integration system is to aggregate electronic health records concerning a particular patient at different healthcare providers' systems to provide a complete medical history of the patient. It holds the promise to address the two most crucial challenges to the healthcare systems: improving healthcare quality and controlling costs. Typical approaches for the national integration of electronic health records are a centralized architecture and a distributed architecture. This paper proposes a new approach for the national integration of electronic health records, the semi-centralized approach, an intermediate solution between the centralized architecture and the distributed architecture that has the benefits of both approaches. The semi-centralized approach is provided with a clearly defined architecture. The main data elements needed by the system are defined and the main system modules that are necessary to achieve an effective and efficient functionality of the system are designed. Best practices and essential requirements are central to the evolution of the proposed architecture. The proposed architecture will provide the basis for designing the simplest and the most effective systems to integrate electronic health records on a nation-wide basis that maintain integrity and consistency across locations, time and systems, and that meet the challenges of interoperability, security, privacy, maintainability, mobility, availability, scalability, and load balancing.

  12. Emulation-based comparative study of centralized and distributed control schemes for optical networks

    Science.gov (United States)

    Xin, Chunsheng; Ye, Yinghua; Dixit, Sudhir; Qiao, Chunming

    2001-07-01

    Recently there are considerable amount of research about the automatic control and provisioning in all optical networks. One of the critical issues is how to provide effective lightpath provisioning to improve network performance, such as blocking probability and decision time. Depending on the network topology, configuration, and administration policy, a distributed or centralized control scheme can be employed to manage the routing and signaling. In a distributed control scheme, each node exchanges information with other nodes, but performs routing and signaling independently from other nodes. On the other hand, in a centralized scheme, each node communicates with a central controller and the controller performs routing and signaling on behalf of all other nodes. Intuitively, the centralized scheme can obtain a lower blocking probability since the controller has the complete resource availability information. We have studied the two schemes through emulations, determined the signaling and processing overheads and quantified the conditions that favor one approach over the other.

  13. Attenuation of Morphine Physical Dependence and Blood Levels of Cortisol by Central and Systemic Administration of Ramelteon in Rat

    Directory of Open Access Journals (Sweden)

    Majid Motaghinejad

    2015-05-01

    Full Text Available Background: Chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. The aim of this study is the assessment of systemic and intracerebroventricular (icv administration of ramelteon (a melatonin receptor agonist on morphine physical dependence. Methods: 88 adult male rats were divided into 2 major groups, namely “systematic” and “central” administration of ramelteon. In the first category, systemic administration of ramelteon at various dosages (10, 20, and 40 mg/kg was assessed on dependent animals and withdrawal signs were compared with positive (received morphine and saline as systemic administration, negative control (saline and group under treatment by ramelteon (40 mg/kg groups. In the second category, central administration of ramelteon at various dosages (25, 50, or 100 μg, was assessed on dependent animals and withdrawal signs were compared with the positive control (received morphine and saline as icv and negative control (saline groups, and the group under treatment by ramelteon (50 μg/5 μl/rat. On the test day, all animals received naloxone (3 mg/kg and were observed for withdrawal signs. Total withdrawal score (TWS was also determined. Finally, to evaluate the stress level of dependent rats, blood cortisols were measured. Results: Central administration of ramelteon in all doses and systemic administration in high doses attenuate withdrawal syndrome in comparison with the dependent positive control group (P<0.05. Both central and systemic administrations of ramelteon can attenuate the blood cortisol level in comparison with the dependent positive control group (P<0.05. Conclusion: In conclusion, we found that central administration of ramelteon attenuated morphine withdrawal symptoms and cortisol level as a stress marker.

  14. Marine Tactical Command and Control System (MTACCS) Field Development System-1 (FDS-1) assessment: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Avery, L.W.; Hunt, S.T.; Savage, S.F. (Pacific Northwest Lab., Richland, WA (United States)); McLaughlin, P.D.; Shepdard, A.P.; Worl, J.C. (Battelle Seattle Research Center, WA (United States))

    1992-04-01

    The United State Marine Corps (USMC) is continuing the development and fielding of the Marine Corps Tactical Command and Control System (MTACCS), a system which exists in varying states of development, fielding, or modernization. MTACCS is currently composed of the following components: Tactical Combat Operations System (TCO) for ground command and control (C2), Intelligence Analysis System (IAS) with a Genser terminal connected to a TCO workstation for intelligence C2, Marine Integrated Personnel System (MIPS) and a TCO workstation using the Marine Combat Personnel System (MCPERS) software for personnel C2, Marine Integrated Logistics System (MILOGS) which is composed of the Landing Force Asset Distribution System (LFADS), the Marine Air-Ground Task Force (MAGTF) II, and a TCO terminal using the Marine Combat Logistics System (MCLOG) for logistics C2, Marine Corps Fire Support System (MCFSS) for fire support C2, and Advanced Tactical Air Command Central (ATACC) and the Improved Direct Air Support Central for aviation C2.

  15. Model based control of refrigeration systems

    Energy Technology Data Exchange (ETDEWEB)

    Sloth Larsen, L.F.

    2005-11-15

    with a distributed control structure, the cross-couplings are not naturally incorporated in the design of the controllers. The disturbances caused by the individual subsystems might be insignificant, however if the effect from all of the subsystems is synchronized it might cause a sever deterioration in the system performance. In the part of the thesis covering dynamical optimization, the main emphasis is laid on analyzing the phenomena of synchronization of hysteresis controlled subsystems. The propose method for desynchronization is based on a model predictive control setup. By formulating a cost function that penalizes the effects of synchronization hard, an optimal control sequence for the subsystems can be computed that desynchronizes the operation. A supermarket's refrigeration system consists of a number of refrigerated display cases located in the supermarkets sales area. The display cases are connected to a central refrigeration system, moreover the temperature control in the display cases is carried out by hysteresis controller. Practice however shows that the display cases have a tendency to synchronize the temperature control. This cause periodically high loads on the central refrigeration system and thereby an increased energy consumption and wear. By studying a nonlinear system model it has been analyzed, which parameter that are important for the synchronization. Applying the proposed method on the nonlinear system model has proved that it is capable of desynchronizing the operation of the display cases. (au)

  16. Centralized Stochastic Optimal Control of Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Malikopoulos, Andreas [ORNL

    2015-01-01

    In this paper we address the problem of online optimization of the supervisory power management control in parallel hybrid electric vehicles (HEVs). We model HEV operation as a controlled Markov chain using the long-run expected average cost per unit time criterion, and we show that the control policy yielding the Pareto optimal solution minimizes the average cost criterion online. The effectiveness of the proposed solution is validated through simulation and compared to the solution derived with dynamic programming using the average cost criterion.

  17. Fusimotor control of spindle sensitivity regulates central and peripheral coding of joint angles.

    Science.gov (United States)

    Lan, Ning; He, Xin

    2012-01-01

    Proprioceptive afferents from muscle spindles encode information about peripheral joint movements for the central nervous system (CNS). The sensitivity of muscle spindle is nonlinearly dependent on the activation of gamma (γ) motoneurons in the spinal cord that receives inputs from the motor cortex. How fusimotor control of spindle sensitivity affects proprioceptive coding of joint position is not clear. Furthermore, what information is carried in the fusimotor signal from the motor cortex to the muscle spindle is largely unknown. In this study, we addressed the issue of communication between the central and peripheral sensorimotor systems using a computational approach based on the virtual arm (VA) model. In simulation experiments within the operational range of joint movements, the gamma static commands (γ(s)) to the spindles of both mono-articular and bi-articular muscles were hypothesized (1) to remain constant, (2) to be modulated with joint angles linearly, and (3) to be modulated with joint angles nonlinearly. Simulation results revealed a nonlinear landscape of Ia afferent with respect to both γ(s) activation and joint angle. Among the three hypotheses, the constant and linear strategies did not yield Ia responses that matched the experimental data, and therefore, were rejected as plausible strategies of spindle sensitivity control. However, if γ(s) commands were quadratically modulated with joint angles, a robust linear relation between Ia afferents and joint angles could be obtained in both mono-articular and bi-articular muscles. With the quadratic strategy of spindle sensitivity control, γ(s) commands may serve as the CNS outputs that inform the periphery of central coding of joint angles. The results suggest that the information of joint angles may be communicated between the CNS and muscles via the descending γ(s) efferent and Ia afferent signals.

  18. The APS control system network upgrade

    International Nuclear Information System (INIS)

    Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

    1999-01-01

    When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network

  19. MR findings of primary central nervous system lymphoma in a child

    International Nuclear Information System (INIS)

    Ciftci, E.; Erden, I.; Akyar, S.

    1998-01-01

    MR imaging of a rare case of primary central nervous system lymphoma in a 12-year-old boy with headache and seizure is presented. MR imaging showed a mass lesion located in the corpus callosum. Diagnosis was made by stereotactic biopsy. The patient was treated with radiotherapy. Early control MR imaging showed a decrease in tumor size but after 12 months an increase in tumor size was detected. (orig.)

  20. NSTX-U Control System Upgrades

    International Nuclear Information System (INIS)

    Erickson, K.G.; Gates, D.A.; Gerhardt, S.P.; Lawson, J.E.; Mozulay, R.; Sichta, P.; Tchilinguirian, G.J.

    2014-01-01

    The National Spherical Tokamak Experiment (NSTX) is undergoing a wealth of upgrades (NSTX-U). These upgrades, especially including an elongated pulse length, require broad changes to the control system that has served NSTX well. A new fiber serial Front Panel Data Port input and output (I/O) stream will supersede the aging copper parallel version. Driver support for the new I/O and cyber security concerns require updating the operating system from Redhat Enterprise Linux (RHEL) v4 to RedHawk (based on RHEL) v6. While the basic control system continues to use the General Atomics Plasma Control System (GA PCS), the effort to forward port the entire software package to run under 64-bit Linux instead of 32-bit Linux included PCS modifications subsequently shared with GA and other PCS users. Software updates focused on three key areas: (1) code modernization through coding standards (C99/C11), (2) code portability and maintainability through use of the GA PCS code generator, and (3) support of 64-bit platforms. Central to the control system upgrade is the use of a complete real time (RT) Linux platform provided by Concurrent Computer Corporation, consisting of a computer (iHawk), an operating system and drivers (RedHawk), and RT tools (NightStar). Strong vendor support coupled with an extensive RT toolset influenced this decision. The new real-time Linux platform, I/O, and software engineering will foster enhanced capability and performance for NSTX-U plasma control

  1. NSTX-U Control System Upgrades

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, K.G., E-mail: kerickso@pppl.gov; Gates, D.A.; Gerhardt, S.P.; Lawson, J.E.; Mozulay, R.; Sichta, P.; Tchilinguirian, G.J.

    2014-06-15

    The National Spherical Tokamak Experiment (NSTX) is undergoing a wealth of upgrades (NSTX-U). These upgrades, especially including an elongated pulse length, require broad changes to the control system that has served NSTX well. A new fiber serial Front Panel Data Port input and output (I/O) stream will supersede the aging copper parallel version. Driver support for the new I/O and cyber security concerns require updating the operating system from Redhat Enterprise Linux (RHEL) v4 to RedHawk (based on RHEL) v6. While the basic control system continues to use the General Atomics Plasma Control System (GA PCS), the effort to forward port the entire software package to run under 64-bit Linux instead of 32-bit Linux included PCS modifications subsequently shared with GA and other PCS users. Software updates focused on three key areas: (1) code modernization through coding standards (C99/C11), (2) code portability and maintainability through use of the GA PCS code generator, and (3) support of 64-bit platforms. Central to the control system upgrade is the use of a complete real time (RT) Linux platform provided by Concurrent Computer Corporation, consisting of a computer (iHawk), an operating system and drivers (RedHawk), and RT tools (NightStar). Strong vendor support coupled with an extensive RT toolset influenced this decision. The new real-time Linux platform, I/O, and software engineering will foster enhanced capability and performance for NSTX-U plasma control.

  2. NCPC Central Files Information System (CFIS)

    Data.gov (United States)

    National Capital Planning Commission — This dataset contains records from NCPC's Central Files Information System (CFIS), which is a comprehensive database of projects submitted to NCPC for design review...

  3. Upgrading of data acquisition software for centralized radiation monitoring system in Malaysian Nuclear Agency

    Energy Technology Data Exchange (ETDEWEB)

    Yussup, F., E-mail: nolida@nm.gov.my; Ibrahim, M. M., E-mail: maslina-i@nm.gov.my; Soh, S. C.; Hasim, H. [Instrumentation and Automation Centre, Technical Support Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang. Selangor (Malaysia); Haris, M. F. [Information Technology Centre, Technical Support Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang. Selangor (Malaysia); Azman, A. [Prototype and Development Centre, Technical Support Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang. Selangor (Malaysia); Razalim, F. A. A.; Yapp, R. [Health Physics Group, Radiation Safety and Health Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang. Selangor (Malaysia); Ramli, A. A. M. [Technical Support Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang. Selangor (Malaysia)

    2016-01-22

    With the growth of technology, many devices and equipments can be connected to the network and internet to enable online data acquisition for real-time data monitoring and control from monitoring devices located at remote sites. Centralized radiation monitoring system (CRMS) is a system that enables area radiation level at various locations in Malaysian Nuclear Agency (Nuklear Malaysia) to be monitored centrally by using a web browser. The Local Area Network (LAN) in Nuclear Malaysia is utilized in CRMS as a communication media for data acquisition of the area radiation levels from radiation detectors. The development of the system involves device configuration, wiring, network and hardware installation, software and web development. This paper describes the software upgrading on the system server that is responsible to acquire and record the area radiation readings from the detectors. The recorded readings are called in a web programming to be displayed on a website. Besides the main feature which is acquiring the area radiation levels in Nuclear Malaysia centrally, the upgrading involves new features such as uniform time interval for data recording and exporting, warning system and dose triggering.

  4. Upgrading of data acquisition software for centralized radiation monitoring system in Malaysian Nuclear Agency

    International Nuclear Information System (INIS)

    Yussup, F.; Ibrahim, M. M.; Soh, S. C.; Hasim, H.; Haris, M. F.; Azman, A.; Razalim, F. A. A.; Yapp, R.; Ramli, A. A. M.

    2016-01-01

    With the growth of technology, many devices and equipments can be connected to the network and internet to enable online data acquisition for real-time data monitoring and control from monitoring devices located at remote sites. Centralized radiation monitoring system (CRMS) is a system that enables area radiation level at various locations in Malaysian Nuclear Agency (Nuklear Malaysia) to be monitored centrally by using a web browser. The Local Area Network (LAN) in Nuclear Malaysia is utilized in CRMS as a communication media for data acquisition of the area radiation levels from radiation detectors. The development of the system involves device configuration, wiring, network and hardware installation, software and web development. This paper describes the software upgrading on the system server that is responsible to acquire and record the area radiation readings from the detectors. The recorded readings are called in a web programming to be displayed on a website. Besides the main feature which is acquiring the area radiation levels in Nuclear Malaysia centrally, the upgrading involves new features such as uniform time interval for data recording and exporting, warning system and dose triggering

  5. Modular control system for embedded applications

    Directory of Open Access Journals (Sweden)

    Dostálek Petr

    2016-01-01

    Full Text Available This paper deals with hardware design of a modular control system intended for embedded applications demanding high computational power while maintaining low cost. The control system central unit is based on 32bit microcontroller MK60DN512 with ARM Cortex-M4 core manufactured by NXP Semiconductor. Module provides all the necessary signals on the two 2-row 40 pin headers and Ethernet communication interface in the form of a small daughter board. It is connected to the mainboard which must always contain 5 V stabilized power supply; other circuits are application specific. In our application the mainboard is equipped with SD card slot, RS232 and RS485 interface which is used for high speed interconnection with up to 15 expansion peripheral modules. This concept enables high flexibility to specific application demands without necessity of redesigning the control system. Controller is freely programmable in C language using any compatible integrated development environment – NXP Kinetis Design Studio, for example. Software development and debugging is simplified by our support program libraries including necessary routines for control and monitoring tasks.

  6. Centralized Control/Decentralized Execution: A Valid Tenet of Airpower

    National Research Council Canada - National Science Library

    Santicola, Henry J

    2005-01-01

    ...) and Effects-Based Operations (EBO). This paper examines the history of the concept of centralized control/decentralized execution from the advent of modern warfare through Operation Enduring Freedom...

  7. Time presses for the installation of a central controller [in the energy supply industry]. Strategic re-orientation of the present system

    International Nuclear Information System (INIS)

    Van den Berg, R.J.; Van Essen, M.; Meulmeester, P.; Olde Rikkert, B.

    2007-01-01

    The installation of a so-called central controller for the electric power industry has a number of advantages for stakeholders in the energy market: improving the exchange of information between energy utilities, save costs by setting up central registers for connections, meters, measured data and central processes for e.g. reconciliation and management of measured data (in particular with regard to smart metering). As an example attention is paid to the NEMMCO-case (National Electricity Code Administrator) in Australia [nl

  8. Financial regulation and financial system architecture in Central Europe

    NARCIS (Netherlands)

    Scholtens, B

    At the beginning of the transition, advice to Central European countries with respect to how to set up their financial systems was based on models used in western economies. This paper analyzes the experiences to set up a financial system in Central Europe. The experience in the first transition

  9. TCP/IP Communication System for Controlling a Vehicular Traffic Intersection

    Directory of Open Access Journals (Sweden)

    Pedraza-Martínez Luis Fernando

    2013-10-01

    Full Text Available This paper describes the development of a prototype of a vehicular traffic controller, whose system of communication is based on the TCP/IP protocol, in order to re- motely monitor and control the operation of traffic lights for a vehicular intersection. The results show the times of communication between the central and the traffic controller. The conclusions highlight the importance of using the TCP/IP protocol in traffic light systems.

  10. Control of total voltage in the large distributed RF system of LEP

    CERN Document Server

    Ciapala, Edmond

    1995-01-01

    The LEP RF system is made up of a large number of independent RF units situated around the ring near the interaction points. These have different available RF voltages depending on their type and they may be inactive or unable to provide full voltage for certain periods. The original RF voltage control system was based on local RF unit voltage function generators pre-loaded with individual tables for energy ramping. This was replaced this year by a more flexible global RF voltage control system. A central controller in the main control room has direct access to the units over the LEP TDM system via multiplexers and local serial links. It continuously checks the state of all the units and adjusts their voltages to maintain the desired total voltage under all conditions. This voltage is distributed among the individual units to reduce the adverse effects of RF voltage asymmetry around the machine as far as possible. The central controller is a VME system with 68040 CPU and real time multitasking operating syste...

  11. The interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks.

    Science.gov (United States)

    Mokhtarpouriani, Kasra; Zendehdel, Morteza; Jonaidi, Hossein; Babapour, Vahab; Shayan, Parviz

    2016-05-01

    Most physiological behaviors such as food intake are controlled by the hypothalamus and its nuclei. It has been demonstrated that injection of the paraventricular nucleus of the hypothalamus with nitric oxide (NO) donors elicited changes in the concentration of some amino acids, including GABA. Also, central nitrergic and GABAergic systems are known to provide inputs to the paraventricular nucleus and are involved in food intake control. Therefore, the present study examines the probable interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks. The results of this study showed that intracerebroventricular (ICV) injection of L-arginine (400 and 800 nmol), as a NO donor, significantly decreased food intake (P 0.05). Also, the hypophagic effect of L-arginine (800 nmol) was significantly amplified in ICV co-injection of picrotoxin (0.5 µg), a GABAA antagonist, or CGP54626 (21 ng), a GABAB antagonist, with L-arginine (800 nmol) (P < 0.001). These results probably suggest an interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks and GABAA receptors play a major role in this interaction.

  12. Event detection and exception handling strategies in the ASDEX Upgrade discharge control system

    International Nuclear Information System (INIS)

    Treutterer, W.; Neu, G.; Rapson, C.; Raupp, G.; Zasche, D.; Zehetbauer, T.

    2013-01-01

    Highlights: •Event detection and exception handling is integrated in control system architecture. •Pulse control with local exception handling and pulse supervision with central exception handling are strictly separated. •Local exception handling limits the effect of an exception to a minimal part of the controlled system. •Central Exception Handling solves problems requiring coordinated action of multiple control components. -- Abstract: Thermonuclear plasmas are governed by nonlinear characteristics: plasma operation can be classified into scenarios with pronounced features like L and H-mode, ELMs or MHD activity. Transitions between them may be treated as events. Similarly, technical systems are also subject to events such as failure of measurement sensors, actuator saturation or violation of machine and plant operation limits. Such situations often are handled with a mixture of pulse abortion and iteratively improved pulse schedule reference programming. In case of protection-relevant events, however, the complexity of even a medium-sized device as ASDEX Upgrade requires a sophisticated and coordinated shutdown procedure rather than a simple stop of the pulse. The detection of events and their intelligent handling by the control system has been shown to be valuable also in terms of saving experiment time and cost. This paper outlines how ASDEX Upgrade's discharge control system (DCS) detects events and handles exceptions in two stages: locally and centrally. The goal of local exception handling is to limit the effect of an unexpected or asynchronous event to a minimal part of the controlled system. Thus, local exception handling facilitates robustness to failures but keeps the decision structures lean. A central state machine deals with exceptions requiring coordinated action of multiple control components. DCS implements the state machine by means of pulse schedule segments containing pre-programmed waveforms to define discharge goal and control

  13. Event detection and exception handling strategies in the ASDEX Upgrade discharge control system

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, W., E-mail: Wolfgang.Treutterer@ipp.mpg.de; Neu, G.; Rapson, C.; Raupp, G.; Zasche, D.; Zehetbauer, T.

    2013-10-15

    Highlights: •Event detection and exception handling is integrated in control system architecture. •Pulse control with local exception handling and pulse supervision with central exception handling are strictly separated. •Local exception handling limits the effect of an exception to a minimal part of the controlled system. •Central Exception Handling solves problems requiring coordinated action of multiple control components. -- Abstract: Thermonuclear plasmas are governed by nonlinear characteristics: plasma operation can be classified into scenarios with pronounced features like L and H-mode, ELMs or MHD activity. Transitions between them may be treated as events. Similarly, technical systems are also subject to events such as failure of measurement sensors, actuator saturation or violation of machine and plant operation limits. Such situations often are handled with a mixture of pulse abortion and iteratively improved pulse schedule reference programming. In case of protection-relevant events, however, the complexity of even a medium-sized device as ASDEX Upgrade requires a sophisticated and coordinated shutdown procedure rather than a simple stop of the pulse. The detection of events and their intelligent handling by the control system has been shown to be valuable also in terms of saving experiment time and cost. This paper outlines how ASDEX Upgrade's discharge control system (DCS) detects events and handles exceptions in two stages: locally and centrally. The goal of local exception handling is to limit the effect of an unexpected or asynchronous event to a minimal part of the controlled system. Thus, local exception handling facilitates robustness to failures but keeps the decision structures lean. A central state machine deals with exceptions requiring coordinated action of multiple control components. DCS implements the state machine by means of pulse schedule segments containing pre-programmed waveforms to define discharge goal and control

  14. Study of global control of VIRGO Central Interferometer; Etude du controle global de l'Interferometre Central de VIRGO

    Energy Technology Data Exchange (ETDEWEB)

    Matone, Luca [Paris-11 Univ., 91 Orsay (France)

    1999-10-29

    The VIRGO project for the detection of gravitational waves will first operate in a test configuration, known as the Central Area Interferometer (CITF). The subject of this thesis consists of a study for the global control of this interferometer. In particular, the problems of auto-alignment and acquisition of lock are addressed. First, an investigation of the CITF optical response to longitudinal and angular mirror movements is given. On the basis of this study, we show how the ratio of photodiode signals can be used to detect and control the dark fringe when the CITF is far from its operating point (locked state). Furthermore, we present the simulation results of a quadrant photodiode configuration capable of reconstructing the mirrors' tilts once the CITF is in a locked state. The performance of a control system for the auto-alignment is then given. A study on the mode-cleaner prototype MC30 is then introduced in order to comprehend the process of lock acquisition by a linear feedback system for two different finesse values: F {approx_equal}100 and F {approx_equal} 1600. We define a threshold velocity for the mirrors' relative motion below which acquisition of lock is possible. A phenomenon, referred to as ringing effect, was observed and examined on the MC30 prototype in high finesse. The results of numerical calculations allowed us to fit measurement and estimate from them the cavity finesse as well as the mirrors' relative velocity during the resonance crossing. An empirical formula is then presented capable of determine the relative velocity from the positions of the oscillations' minima and maxima. An algorithm to guide into lock the CITF is then presented, consisting of an iterative procedure of velocity reconstruction and pulse application. A numerical calculation simulated the algorithm, the mirrors' motion, the optical response and the ADCs' process. As a result, acquisition times of the order of one second were observed: an improvement of more than one

  15. Spontaneous centralization of control in a network of company ownerships.

    Directory of Open Access Journals (Sweden)

    Sebastian M Krause

    Full Text Available We introduce a model for the adaptive evolution of a network of company ownerships. In a recent work it has been shown that the empirical global network of corporate control is marked by a central, tightly connected "core" made of a small number of large companies which control a significant part of the global economy. Here we show how a simple, adaptive "rich get richer" dynamics can account for this characteristic, which incorporates the increased buying power of more influential companies, and in turn results in even higher control. We conclude that this kind of centralized structure can emerge without it being an explicit goal of these companies, or as a result of a well-organized strategy.

  16. An automated entry control system for nuclear facilities

    International Nuclear Information System (INIS)

    Ream, W.K.; Espinoza, J.

    1985-01-01

    An entry control system to automatically control access to nuclear facilities is described. The design uses a centrally located console, integrated into the regular security system, to monitor the computer-controlled passage into and out of sensitive areas. Four types of entry control points are used: an unmanned enclosed portal with metal and SNM detectors for contraband detection with positive personnel identification, a bypass portal for contraband search after a contraband alarm in a regular portal also with positive personnel identification, a single door entry point with positive personnel identification, and a single door entry point with only a magnetic card-type identification. Security force action is required only as a response to an alarm. The integration of the entry control function into the security system computer is also described. The interface between the entry control system and the monitoring security personnel utilizing a color graphics display with touch screen input is emphasized

  17. Tolerance of the central nervous system to photon irradiation

    International Nuclear Information System (INIS)

    Wigg, D.R.; Murray, R.M.L.; Koschel, K.

    1982-01-01

    Dose-response isoeffect equations have been determined for hypothalamic pituitary insufficiency following cranial irradiation. Of particular importance is the occurrence of complications at doses substantially less than those commonly used for the treatment of central nervous system tumors. Such complications may be severe and potentially life threatening. These complications occur when a small midline 'target' volume containing the pituitary gland, infundibulum and adjacent inferior hypothalamic structures is irradiated. Direct pituitary irradiation is unlikely to be a factor, at least in some cases. The possible role of incidental hypothalamic irradiation in the control of acromegaly and pituitary dependent Cushing's syndrome is discussed. (Auth.)

  18. Price-based optimal control of electrical power systems

    OpenAIRE

    Jokic, A.

    2007-01-01

    During the past decade, electrical power systems have been going through some major restructuring processes. From monopolistic, highly regulated and one utility controlled operation, a system is being restructured to include many parties competing for energy production and consumption, and for provision of many of the ancillary services necessary for system operation. With the emergence of competitive markets as central operational mechanisms, the prime operational objective has shifted from ...

  19. Checkpoints to the Brain: Directing Myeloid Cell Migration to the Central Nervous System

    Directory of Open Access Journals (Sweden)

    Meredith Harrison-Brown

    2016-12-01

    Full Text Available Myeloid cells are a unique subset of leukocytes with a diverse array of functions within the central nervous system during health and disease. Advances in understanding of the unique properties of these cells have inspired interest in their use as delivery vehicles for therapeutic genes, proteins, and drugs, or as “assistants” in the clean-up of aggregated proteins and other molecules when existing drainage systems are no longer adequate. The trafficking of myeloid cells from the periphery to the central nervous system is subject to complex cellular and molecular controls with several ‘checkpoints’ from the blood to their destination in the brain parenchyma. As important components of the neurovascular unit, the functional state changes associated with lineage heterogeneity of myeloid cells are increasingly recognized as important for disease progression. In this review, we discuss some of the cellular elements associated with formation and function of the neurovascular unit, and present an update on the impact of myeloid cells on central nervous system (CNS diseases in the laboratory and the clinic. We then discuss emerging strategies for harnessing the potential of site-directed myeloid cell homing to the CNS, and identify promising avenues for future research, with particular emphasis on the importance of untangling the functional heterogeneity within existing myeloid subsets.

  20. The KSTAR integrated control system based on EPICS

    International Nuclear Information System (INIS)

    Kim, K.H.; Ju, C.J.; Kim, M.K.; Park, M.K.; Choi, J.W.; Kyum, M.C.; Kwon, M.

    2006-01-01

    The Korea Superconducting Tokamak Advanced Research (KSTAR) control system will be developed with several subsystems, which consist of the central control system (e.g. plasma control, machine control, diagnostic control, time synchronization, and interlock systems) and local control systems for various subsystems. We are planning to connect the entire system with several networks, viz. a reflective-memory-based real-time network, an optical timing network, a gigabit Ethernet network for generic machine control, and a storage network. Then it will evolve into a network-based, distributed real-time control system. Thus, we have to consider the standard communication protocols among the subsystems and how to handle the various kinds of hardware in a homogeneous way. To satisfy these requirements, EPICS has been chosen for the KSTAR control. The EPICS framework provides network-based real-time distributed control, operating system independent programming tools, operator interface tools, archiving tools, and interface tools with other commercial and non-commercial software. The most important advantage of the use of the EPICS framework is in providing homogeneity of the system for the control system developer. The developer does not have to be concerned about the specifics of the local system, but can concentrate on the implementation of the control logic with EPICS tools. We will present the details of the integration issues and also will give a brief summary of the entire KSTAR control system from an integration point of view

  1. Recent advances in central cardiovascular control: sex, ROS, gas and inflammation [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Pauline M. Smith

    2016-03-01

    Full Text Available The central nervous system (CNS in concert with the heart and vasculature is essential to maintaining cardiovascular (CV homeostasis. In recent years, our understanding of CNS control of blood pressure regulation (and dysregulation leading to hypertension has evolved substantially to include (i the actions of signaling molecules that are not classically viewed as CV signaling molecules, some of which exert effects at CNS targets in a non-traditional manner, and (ii CNS locations not traditionally viewed as central autonomic cardiovascular centers. This review summarizes recent work implicating immune signals and reproductive hormones, as well as gasotransmitters and reactive oxygen species in the pathogenesis of hypertension at traditional CV control centers. Additionally, recent work implicating non-conventional CNS structures in CV regulation is discussed.

  2. A bottom-up approach to automatically configured Tango control systems

    International Nuclear Information System (INIS)

    Rubio-Manrique, S.; Beltran, D.; Costa, I.; Fernandez-Carreiras, D.; Gigante, J.V.; Klora, J.; Matilla, O.; Ranz, R.; Ribas, J.; Sanchez, O.

    2012-01-01

    Alba is the first synchrotron light source built in Spain. Most of Alba control system has been developed on top of Tango control system. An amount of 5531 devices are controlled in Alba accelerators (linac, booster and storage ring) using 150 Linux PCs. Alba maintains a central repository, so called 'Cabling and Controls database' (CCDB), which keeps the inventory of equipment, cables, connections and their configuration and technical specifications. The valuable information kept in this MySQL database enables some tools to automatically create and configure Tango devices and other software components of the control systems of Accelerators, beamlines and laboratories. This paper describes the process involved in this automatic setup

  3. Centralized versus distributed propulsion

    Science.gov (United States)

    Clark, J. P.

    1982-01-01

    The functions and requirements of auxiliary propulsion systems are reviewed. None of the three major tasks (attitude control, stationkeeping, and shape control) can be performed by a collection of thrusters at a single central location. If a centralized system is defined as a collection of separated clusters, made up of the minimum number of propulsion units, then such a system can provide attitude control and stationkeeping for most vehicles. A distributed propulsion system is characterized by more numerous propulsion units in a regularly distributed arrangement. Various proposed large space systems are reviewed and it is concluded that centralized auxiliary propulsion is best suited to vehicles with a relatively rigid core. These vehicles may carry a number of flexible or movable appendages. A second group, consisting of one or more large flexible flat plates, may need distributed propulsion for shape control. There is a third group, consisting of vehicles built up from multiple shuttle launches, which may be forced into a distributed system because of the need to add additional propulsion units as the vehicles grow. The effects of distributed propulsion on a beam-like structure were examined. The deflection of the structure under both translational and rotational thrusts is shown as a function of the number of equally spaced thrusters. When two thrusters only are used it is shown that location is an important parameter. The possibility of using distributed propulsion to achieve minimum overall system weight is also examined. Finally, an examination of the active damping by distributed propulsion is described.

  4. Renewable energy management through microgrid central controller design: An approach to integrate solar, wind and biomass with battery

    Directory of Open Access Journals (Sweden)

    Zaheeruddin

    2015-11-01

    Full Text Available In this study, an isolated microgrid comprising of renewable energy (RE sources like wind, solar, biogas and battery is considered. Provision of utility grid insertion is also given if total microgrid sources falls short of supplying the total load. To establish an efficient energy management strategy, a central controller takes the decision based on the status of the loads and sources. The status is obtained with the assistance of multi-agent concept (treating each source and load as an agent. The data acquisition system of these renewable sources and loads consists of multiple sensors interconnected through Low Power Radio over one of many GPRS communication. The Microgrid Central Controller (MGCC would use an embedded energy management algorithm to take decisions, which are then transmitted to the controllable RE systems to manage the utilization of their power outputs as per the load-supply power balance. A control strategy is adopted to regulate the power output from the battery in case of supply shortage, which results in a floating battery scheme in steady state.

  5. An integrated computer control system for the ANU linac

    Science.gov (United States)

    Davidson, P. M.; Foote, G. S.

    1996-02-01

    One facet of the installation of the superconducting linac at the ANU is the need for computer control of a variety of systems, such as beam transport, resonator RF, cryogenics and others. To accommodate this, a number of control interfaces (for example, analogue signals and RS232 serial lines) must be employed. Ideally, all of the systems should be able to be controlled from a central location, remote from the actual devices. To this end a system based around VAX computers and VME crates has been designed and is currently being developed and implemented. A VAXstation is used to issue control messages and perform high-level functions, while VME crates containing appropriate modules (primarily DACs, ADCs and digital I/O boards) control the devices. The controllers in the VME crates are AEON rtVAX modules running a real-time operating system. Communication with the VAXstation is via DECnet, on a private ethernet to allow communication rates unaffected by unrelated network activity and potentially increasing the security of the system by providing a possible network isolation point. Also on this ethernet are a number of terminal servers to control RS232 devices. A central database contains all device control and monitoring parameters. The main control process running on the VAXstation is responsible for maintaining the current values of the parameters in the database and for dispatching control messages to the appropriate VME crate or RS232 serial line. Separate graphical interface processes allow the operator to interact with the control process, communicating through shared memory. Many graphics processes can be active simultaneously, displaying either on a single or on multiple terminals. Software running on the rtVAX controllers handles the low-level device-specific control by translating messages from the main control process to VME commands which set hardware outputs on VME modules. Similarly, requests for the value of a parameter result in the rtVAX program

  6. CT diagnosis of congenital anomalies of the central nervous system

    International Nuclear Information System (INIS)

    Mori, Koreaki

    1980-01-01

    In the diagnosis of central nervous system congenital anomalies, understanding of embryology of the central nervous system and pathophysiology of each anomaly are essential. It is important for clinical approach to central nervous system congenital anomalies to evaluate the size of the head and tention of the anterior fontanelle. Accurate diagnosis of congenital anomalies depends on a correlation of CT findings to clinical pictures. Clinical diagnosis of congenital anomalies should include prediction of treatability and prognosis, in addition to recognition of a disease. (author)

  7. HETDEX tracker control system design and implementation

    Science.gov (United States)

    Beno, Joseph H.; Hayes, Richard; Leck, Ron; Penney, Charles; Soukup, Ian

    2012-09-01

    To enable the Hobby-Eberly Telescope Dark Energy Experiment, The University of Texas at Austin Center for Electromechanics and McDonald Observatory developed a precision tracker and control system - an 18,000 kg robot to position a 3,100 kg payload within 10 microns of a desired dynamic track. Performance requirements to meet science needs and safety requirements that emerged from detailed Failure Modes and Effects Analysis resulted in a system of 13 precision controlled actuators and 100 additional analog and digital devices (primarily sensors and safety limit switches). Due to this complexity, demanding accuracy requirements, and stringent safety requirements, two independent control systems were developed. First, a versatile and easily configurable centralized control system that links with modeling and simulation tools during the hardware and software design process was deemed essential for normal operation including motion control. A second, parallel, control system, the Hardware Fault Controller (HFC) provides independent monitoring and fault control through a dedicated microcontroller to force a safe, controlled shutdown of the entire system in the event a fault is detected. Motion controls were developed in a Matlab-Simulink simulation environment, and coupled with dSPACE controller hardware. The dSPACE real-time operating system collects sensor information; motor commands are transmitted over a PROFIBUS network to servo amplifiers and drive motor status is received over the same network. To interface the dSPACE controller directly to absolute Heidenhain sensors with EnDat 2.2 protocol, a custom communication board was developed. This paper covers details of operational control software, the HFC, algorithms, tuning, debugging, testing, and lessons learned.

  8. FPGA based control system for -100 kV, 25 A Crowbarless DC power supply

    International Nuclear Information System (INIS)

    Upadhyay, R.; Tripathi, A.; Badapanda, M.K.; Lad, M.

    2015-01-01

    FPGA based digital control system has been developed for -100 kV, 25 A solid state modular crowbarless DC klystron bias power supply of 1 MW, 352.2 MHz RF test stand. The control system has capability to operate this power supply either in CW or pulse mode. Central controller, PSM controller and graphical user interface are key parts of this control system. Central controller monitors the status of various subsystems of this power supply like 11 kV step start unit, four numbers of main transformers each having 44 numbers of secondary windings and 176 numbers of switch power modules for deciding the number of power modules to be put ON and their duty cycles depending on the set output voltage and current. PSM controller sends appropriate control signal to the switch power modules through fibre optic lines and communicates it to the central controller. Linux based graphical user interface has been developed which enables the user to set the operating parameters along with their trip limits and displays the information of critical parameters of this power supply on a local touch screen panel. Provision for remote control and supervision is also provided through a separate PC connected to the main control system via Ethernet. The control system has capability to trip the power supply within 5 μsec in case any parameter exceeds its set limit. Suitable data logging feature is incorporated for offline fault analysis. The control system architecture along with its software protection interlocks are presented in this paper. The performance of the control system has been verified during operation of -100 kV, 25 A DC power supply with 1 MW, 352.2 MHz klystron amplifier. (author)

  9. Control system for gamma camera

    International Nuclear Information System (INIS)

    Miller, D.W.

    1977-01-01

    An improved gamma camera arrangement is described which utilizing a solid state detector, formed of high purity germanium. the central arrangement of the camera operates to effect the carrying out of a trapezoidal filtering operation over antisymmetrically summed spatial signals through gated integration procedures utilizing idealized integrating intervals. By simultaneously carrying out peak energy evaluation of the input signals, a desirable control over pulse pile-up phenomena is achieved. Additionally, through the use of the time derivative of incoming pulse or signal energy information to initially enable the control system, a low level information evaluation is provided serving to enhance the signal processing efficiency of the camera

  10. Multiagent based protection and control in decentralized electric power systems

    DEFF Research Database (Denmark)

    Saleem, Arshad; Lind, Morten; Veloso, Manuela

    2010-01-01

    Electric power systems are going through a major change both in their physical and control structure. A large num- ber of small and geographically dispersed power generation units (e.g., wind turbines, solar cells, plug-in electric cars) are replacing big centralized power plants. This shift has...... created interesting possibilities for application of intelligent systems such as multiagent systems for control and automation in electric power systems. This paper describes work on designing a multiagent system for protection and control of electric power distribution networks.It demonstrates how...... explicit modeling of capabilities, states, roles and role transition in agents can capture the control and automation in electric power systems. We present illustrative results from using our proposed schema in realistic simulations....

  11. Centralized motion control of a linear tooth belt drive: Analysis of the performance and limitations

    Energy Technology Data Exchange (ETDEWEB)

    Jokinen, M.

    2010-07-01

    A centralized robust position control for an electrical driven tooth belt drive is designed in this doctoral thesis. Both a cascaded control structure and a PID based position controller are discussed. The performance and the limitations of the system are analyzed and design principles for the mechanical structure and the control design are given. These design principles are also suitable for most of the motion control applications, where mechanical resonance frequencies and control loop delays are present. One of the major challenges in the design of a controller for machinery applications is that the values of the parameters in the system model (parameter uncertainty) or the system model it self (non-parametric uncertainty) are seldom known accurately in advance. In this thesis a systematic analysis of the parameter uncertainty of the linear tooth beltdrive model is presented and the effect of the variation of a single parameter on the performance of the total system is shown. The total variation of the model parameters is taken into account in the control design phase using a Quantitative Feedback Theory (QFT). The thesis also introduces a new method to analyze reference feedforward controllers applying the QFT. The performance of the designed controllers is verified by experimental measurements. The measurements confirm the control design principles that are given in this thesis. (orig.)

  12. Distributed intelligence in a LAN architecture increases the flexibility in control systems for fusion experiments

    International Nuclear Information System (INIS)

    Tenten, W.; Fuss, L.; Hoge, W.

    1987-01-01

    The control system for the TEXTOR Neutral Beam Injectors is designed implementing approved concepts and techniques. A powerful super mini computer serves as a central node between the operators console and the experimental process. Devices form a console for suitable man machine interaction. The link to the process is mainly based on communication with a network of industry standard programmable controllers. A distinction is made between the functionally dedicated and in most cases locally distributed logic controllers, a central controller and the computerized console level. Introduction of such networks in control system for fusion experiments results in a number of advantages

  13. Instrumentation control system in nuclear power plant

    International Nuclear Information System (INIS)

    Hanai, Koi; Tai, Ichiro.

    1982-01-01

    Purpose: To improve the reliability of instrumentation control system in a nuclear power plant by using an optical fiber cable as a transmission path between a multiplexer and a central control room to thereby eliminate noises resulted from electromagnetic inductions or the likes. Constitution: Signals from neutron detectors are sent by way of ceramic-insulated cables to pre-amplifiers disposed outside of the pressure vessel of a nuclear reactor, converted into voltage pulse signals and then sent by way of coaxial cables to a multiplexer. The multiplexer receives a plurality of voltage pulse signals corresponding to the neutron detectors respectively, converts them into a time-shared electric signal train and sends it to an optical pulse transmitter. The transmitter converts the supplied signals into an optical pulse signal train corresponding to the electric signal train from the multiplexer and sends it by way of an optical fiber cable to an optical pulse receiver disposed in a central control room. (Kawakami, Y.)

  14. Baseline Architecture of ITER Control System

    Science.gov (United States)

    Wallander, A.; Di Maio, F.; Journeaux, J.-Y.; Klotz, W.-D.; Makijarvi, P.; Yonekawa, I.

    2011-08-01

    The control system of ITER consists of thousands of computers processing hundreds of thousands of signals. The control system, being the primary tool for operating the machine, shall integrate, control and coordinate all these computers and signals and allow a limited number of staff to operate the machine from a central location with minimum human intervention. The primary functions of the ITER control system are plant control, supervision and coordination, both during experimental pulses and 24/7 continuous operation. The former can be split in three phases; preparation of the experiment by defining all parameters; executing the experiment including distributed feed-back control and finally collecting, archiving, analyzing and presenting all data produced by the experiment. We define the control system as a set of hardware and software components with well defined characteristics. The architecture addresses the organization of these components and their relationship to each other. We distinguish between physical and functional architecture, where the former defines the physical connections and the latter the data flow between components. In this paper, we identify the ITER control system based on the plant breakdown structure. Then, the control system is partitioned into a workable set of bounded subsystems. This partition considers at the same time the completeness and the integration of the subsystems. The components making up subsystems are identified and defined, a naming convention is introduced and the physical networks defined. Special attention is given to timing and real-time communication for distributed control. Finally we discuss baseline technologies for implementing the proposed architecture based on analysis, market surveys, prototyping and benchmarking carried out during the last year.

  15. Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity.

    Science.gov (United States)

    Vucetic, Zivjena; Reyes, Teresa M

    2010-01-01

    Prevalence of obesity in the general population has increased in the past 15 years from 15% to 35%. With increasing obesity, the coincident medical and social consequences are becoming more alarming. Control over food intake is crucial for the maintenance of body weight and represents an important target for the treatment of obesity. Central nervous system mechanisms responsible for control of food intake have evolved to sense the nutrient and energy levels in the organism and to coordinate appropriate responses to adjust energy intake and expenditure. This homeostatic system is crucial for maintenance of stable body weight over long periods of time of uneven energy availability. However, not only the caloric and nutritional value of food but also hedonic and emotional aspects of feeding affect food intake. In modern society, the increased availability of highly palatable and rewarding (fat, sweet) food can significantly affect homeostatic balance, resulting in dysregulated food intake. This review will focus on the role of hypothalamic and mesolimbic/mesocortical dopaminergic (DA) circuitry in coding homeostatic and hedonic signals for the regulation of food intake and maintenance of caloric balance. The interaction of dopamine with peripheral and central indices of nutritional status (e.g., leptin, ghrelin, neuropeptide Y), and the susceptibility of the dopamine system to prenatal insults will be discussed. Additionally, the importance of alterations in dopamine signaling that occur coincidently with obesity will be addressed.

  16. Pazopanib efficacy in recurrent central nervous system hemangiopericytomas.

    Science.gov (United States)

    Apra, Caroline; Alentorn, Agusti; Mokhtari, Karima; Kalamarides, Michel; Sanson, Marc

    2018-04-26

    There is currently no treatment for solitary fibrous tumors/hemangiopericytomas (SFT/H) of the central nervous system recurring after multiple surgeries and radiotherapies. The NAB2-STAT6 gene fusion is the hallmark of these tumors, and upregulates Early Growth Factor, activating several growth pathways. We treated two patients presenting pluri-recurrent meningeal SFT/H with Pazopanib, a broad-spectrum tyrosine kinase inhibitor. We analyzed the exome and RNA sequencing data of one of them and, in addition to another meningeal SFT/H, compared it to the transcriptomic profiling of 5 systemic SFT/H. A dramatic clinical and radiological response was observed in both cases, respectively 84 and 43% decrease after 3 months. As a comparison, Pazopanib has only a stabilizing effect in systemic SFT/H. Indeed, central nervous system SFT/H show overexpression of different tyrosine kinases targeted by Pazopanib. Two consecutive patients with untreatable central nervous system SFT/H showed a spectacular partial response to Pazopanib, an unprecedented result in SFT/H. This result could be explained by differences in expression profiles and calls for a confirmation in a larger cohort of patients.

  17. Axonal Elongation into Peripheral Nervous System ``Bridges'' after Central Nervous System Injury in Adult Rats

    Science.gov (United States)

    David, Samuel; Aguayo, Albert J.

    1981-11-01

    The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as ``bridges'' between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 millimeters. The regenerative potential of these central neurons seems to be expressed when the central nervous system glial environment is changed to that of the peripheral nervous system.

  18. Fermilab 200 MeV linac control system hardware

    Energy Technology Data Exchange (ETDEWEB)

    Shea, M.F.

    1984-01-01

    This report is a description of the present Linac distributed control system that replaces the original Xerox computer and interface electronics with a network of 68000-based stations. In addition to replacing the obsolete Xerox equipment, goals set for the new system were to retain the fast response and interactive nature of the original system, to improve reliability, to ease maintenance, and to provide 15 Hz monitoring of all Linac parameters. Our previous experience with microcomputer installations showed that small, stand-alone control systems are rather straightforward to implement and have been proven to be reliable in operation, even in the severe environment of the 750-keV preaccelerator. The overall design of the Linac system incorporates the concept of many relatively small, stand-alone control systems networked together using an intercomputer communication network. Each station retains its local control system character but takes advantage of the network to allow an operator to interact with the entire Linac from any local console. At the same time, a link to the central computer system allows Host computers to also access parameters in the Linac.

  19. Fermilab 200 MeV linac control system hardware

    International Nuclear Information System (INIS)

    Shea, M.F.

    1984-01-01

    This report is a description of the present Linac distributed control system that replaces the original Xerox computer and interface electronics with a network of 68000-based stations. In addition to replacing the obsolete Xerox equipment, goals set for the new system were to retain the fast response and interactive nature of the original system, to improve reliability, to ease maintenance, and to provide 15 Hz monitoring of all Linac parameters. Our previous experience with microcomputer installations showed that small, stand-alone control systems are rather straightforward to implement and have been proven to be reliable in operation, even in the severe environment of the 750-keV preaccelerator. The overall design of the Linac system incorporates the concept of many relatively small, stand-alone control systems networked together using an intercomputer communication network. Each station retains its local control system character but takes advantage of the network to allow an operator to interact with the entire Linac from any local console. At the same time, a link to the central computer system allows Host computers to also access parameters in the Linac

  20. Supervisory control and data acquisition system development for superconducting current feeder system of SST-1

    International Nuclear Information System (INIS)

    Patel, R.; Mahesuria, G.; Gupta, N.C.; Sonara, D.; Panchal, R.; Panchal, P.; Tanna, V.L.; Pradhan, S.

    2014-01-01

    The Current Feeders System (CFS) is essentially an optimized bridge between the power supply at room temperature and Super Conducting Magnet System (SCMS) of the SST-1 machine at 4.5 K.CFS is a complex electrical and cryogenic network which consists of ten pairs of 10 KA rating helium Vapor cooled Conventional Current Leads (VCCLs), superconducting (SC) current feeder and associated components. For the safe and reliable operation of CFS, it is equipped with different physical process parameters measuring instruments like flow, pressure, temperature, level, vacuum, voltage taps and final control element like control valves, heaters, vacuum pumps etc. PLC program is developed in ladder language for acquiring and controlling the process parameters. Independent SCADA applications developed in WonderwareIntouch software for data communication from PLC, front-end Graphical User Interface (GUI), auto-manual interface, real time trends, history trends, events and alarm pages. Time synchronized communication established between CFS control system and Industrial SQL server (InSQL) Historian for centralized storage of CFS process parameters which intern provides the CFS process data to SST-1 central control room. SCADA based data acquisition and data retrieval system is found to be satisfactory during the recent SST-1 cool down experiment. This paper describes the SCADA and PLC application development and their communication to InSQL server. (author)

  1. Control Strategies to Reduce the Energy Consumption of Central Domestic Hot Water Systems

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, Jordan [The Levy Partnership, Inc., New York, NY (United States). Advanced Residential Integrated Energy Solutions; Ansanelli, Eric [The Levy Partnership, Inc., New York, NY (United States). Advanced Residential Integrated Energy Solutions; Henderson, Hugh [The Levy Partnership, Inc., New York, NY (United States). Advanced Residential Integrated Energy Solutions; Varshney, Kapil [The Levy Partnership, Inc., New York, NY (United States). Advanced Residential Integrated Energy Solutions

    2016-06-23

    Domestic hot water (DHW) heating is the second largest energy end use in U.S. buildings, exceeded only by space conditioning. Recirculation systems consisting of a pump and piping loop(s) are commonly used in multifamily buildings to reduce wait time for hot water at faucets; however, constant pumping increases energy consumption by exposing supply and return line piping to continuous heat loss, even during periods when there is no demand for hot water. In this study, ARIES installed and tested two types of recirculation controls in a pair of buildings in order to evaluate their energy savings potential. Demand control, temperature modulation controls, and the simultaneous operation of both were compared to the baseline case of constant recirculation. Additionally, interactive effects between DHW control fuel reductions and space conditioning (heating and cooling) were estimated in order to make more realistic predictions of the payback and financial viability of retrofitting DHW systems with these controls. Results showed that DHW fuel consumption reduced by 7% after implementing the demand control technique, 2% after implementing temperature modulation, and 15% after implementing demand control and temperature modulation techniques simultaneously; recirculation pump runtime was reduced to 14 minutes or less per day. With space heating and cooling interactions included, the estimated annual cost savings were 8%, 1%, and 14% for the respective control techniques. Possible complications in the installation, commissioning and operation of the controls were identified and solutions offered.

  2. Control Strategies to Reduce the Energy Consumption of Central Domestic Hot Water Systems

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, Jordan; Ansanelli, Eric; Henderson, Hugh; Varshney, Kapil

    2016-06-03

    Domestic hot water (DHW) heating is the second largest energy end use in U.S. buildings, exceeded only by space conditioning. Recirculation systems consisting of a pump and piping loop(s) are commonly used in multifamily buildings to reduce wait time for hot water at faucets; however, constant pumping increases energy consumption by exposing supply and return line piping to continuous heat loss, even during periods when there is no demand for hot water. In this study, ARIES installed and tested two types of recirculation controls in a pair of buildings in order to evaluate their energy savings potential. Demand control, temperature modulation controls, and the simultaneous operation of both were compared to the baseline case of constant recirculation. Additionally, interactive effects between DHW control fuel reductions and space conditioning (heating and cooling) were estimated in order to make more realistic predictions of the payback and financial viability of retrofitting DHW systems with these controls. Results showed that DHW fuel consumption reduced by 7% after implementing the demand control technique, 2% after implementing temperature modulation, and 15% after implementing demand control and temperature modulation techniques simultaneously; recirculation pump runtime was reduced to 14 minutes or less per day. With space heating and cooling interactions included, the estimated annual cost savings were 8%, 1%, and 14% for the respective control techniques. Possible complications in the installation, commissioning and operation of the controls were identified and solutions offered.

  3. Distributed control and data processing system with a centralized database for a BWR power plant

    International Nuclear Information System (INIS)

    Fujii, K.; Neda, T.; Kawamura, A.; Monta, K.; Satoh, K.

    1980-01-01

    Recent digital techniques based on changes in electronics and computer technologies have realized a very wide scale of computer application to BWR Power Plant control and instrumentation. Multifarious computers, from micro to mega, are introduced separately. And to get better control and instrumentation system performance, hierarchical computer complex system architecture has been developed. This paper addresses the hierarchical computer complex system architecture which enables more efficient introduction of computer systems to a Nuclear Power Plant. Distributed control and processing systems, which are the components of the hierarchical computer complex, are described in some detail, and the database for the hierarchical computer complex is also discussed. The hierarchical computer complex system has been developed and is now in the detailed design stage for actual power plant application. (auth)

  4. FY 1999 report on the experimental verification on the establishment of a centralized load control system. Survey of safety of the commercialized system; 1999 nendo fuka shuchu seigyo system kakuritsu jissho shiken jitsuyo system anzensei chosa. Fuka shuchu seigyo system kakuritsu jissho shiken

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For the purpose of leveling load for the residential electric power demand, technical standards for the indirect load control system were studied in FY 1999. As to the systematization of safety standards, made clear were technical standards, items for experiment, etc. for the user equipment monitor control system trially developed/manufactured. Namely, those are tests correspondent to technical standards of electrical appliances, tests on the influence of external agitation, etc., measurement of the leakage electromagnetic field amount, etc. In the study of the energy use optimization support, concepts for optimization were comprehensively asked by the effective air conditioner operation method and from the state surrounding users. Studies were made of effects of the air conditioner control, indices of assessing amenity of users which becomes factors to promote the centralized load control. In the study of the optimum in-house communication method, made were the confirmation of effectiveness of the power-line carrier transmission method, future outlook using other communication technologies, and evaluation of economical efficiency. As to the enhancement of communication reliability, the effectiveness of measures for improvement by alteration to a multi-carrier system transceiver which realizes improvement of the basic performance of equipment was recognized beside the addition of LC circuits which are aimed at improving the communication environment. (NEDO)

  5. DNA methylation-based classification of central nervous system tumours

    DEFF Research Database (Denmark)

    Capper, David; Jones, David T.W.; Sill, Martin

    2018-01-01

    Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging - with substantial inter-observer variabil......Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging - with substantial inter......-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show...

  6. Application of object oriented techniques in the TRIUMF beam line 2C control system

    International Nuclear Information System (INIS)

    Wilkinson, N.A.; Ludgate, G.A.

    1992-07-01

    The KAON Factory central control system study employed a uniform approach to requirements analysis, architectural design and programming based on well established object oriented principles. These principles were applied to the successful analysis, design and implementation of the control system for the TRIUMF Beam Line 2C Solid Target Facility. The specification for this control system was created in collaboration with Beam Line 2C equipment management experts and, once the analysis models were validated, an approach was developed for the direct translation of these models into C code. A commercial real time database was central to this translation, as inter-object data and control flows are implemented by channels in the database. This paper focuses on the experience gained in the use of object oriented techniques during the complete analysis-design-implementation cycle of a working control system and on the utility of implementing such a system using a commercial real time database and graphical interface. (author)

  7. Human engineering evaluation of Hamaoka No. 3 advanced control room CRT display system

    International Nuclear Information System (INIS)

    Okajima, Hiroyuki; Ito, Takahiko; Noguchi, Yoshihiro; Kabasawa, Yoshihiko

    1985-01-01

    As the central control board of Hamaoka No. 3 plant, a new type control board was adopted for the purpose of powerfully supporting the general judgement function of operators by processing enormous plant data in the normal operation and at the time of an accident with a computer, and displaying the results on CRT screens in the summarized form. Recently, the evaluation of this new control board was carried out by ergonomical techniques, and it was confirmed that the initial objective has been attained. Besides, the criteria for the ergonomical evaluation of central control boards mainly for CRT display were determined, and the contents of design were able to be systematically evaluated and verified. As the ergonomical design of the central control board, the easy distinction of the function of switches, the easy confirmation of system constitution by mimics, the use of CRTs, the easy identification of operation pilot lamps, alarms, instruments and so on were considered. The central control board consists of the main control board, auxiliary control boards and vertical boards, and 12 CRTs are installed. (Kako, I.)

  8. Control of Discrete-Event Systems Automata and Petri Net Perspectives

    CERN Document Server

    Silva, Manuel; Schuppen, Jan

    2013-01-01

    Control of Discrete-event Systems provides a survey of the most important topics in the discrete-event systems theory with particular focus on finite-state automata, Petri nets and max-plus algebra. Coverage ranges from introductory material on the basic notions and definitions of discrete-event systems to more recent results. Special attention is given to results on supervisory control, state estimation and fault diagnosis of both centralized and distributed/decentralized systems developed in the framework of the Distributed Supervisory Control of Large Plants (DISC) project. Later parts of the text are devoted to the study of congested systems though fluidization, an over approximation allowing a much more efficient study of observation and control problems of timed Petri nets. Finally, the max-plus algebraic approach to the analysis and control of choice-free systems is also considered. Control of Discrete-event Systems provides an introduction to discrete-event systems for readers that are not familiar wi...

  9. Study of global control of VIRGO Central Interferometer; Etude du controle global de l'Interferometre Central de VIRGO

    Energy Technology Data Exchange (ETDEWEB)

    Matone, Luca [Paris-11 Univ., 91 Orsay (France)

    1999-10-29

    The VIRGO project for the detection of gravitational waves will first operate in a test configuration, known as the Central Area Interferometer (CITF). The subject of this thesis consists of a study for the global control of this interferometer. In particular, the problems of auto-alignment and acquisition of lock are addressed. First, an investigation of the CITF optical response to longitudinal and angular mirror movements is given. On the basis of this study, we show how the ratio of photodiode signals can be used to detect and control the dark fringe when the CITF is far from its operating point (locked state). Furthermore, we present the simulation results of a quadrant photodiode configuration capable of reconstructing the mirrors' tilts once the CITF is in a locked state. The performance of a control system for the auto-alignment is then given. A study on the mode-cleaner prototype MC30 is then introduced in order to comprehend the process of lock acquisition by a linear feedback system for two different finesse values: F {approx_equal}100 and F {approx_equal} 1600. We define a threshold velocity for the mirrors' relative motion below which acquisition of lock is possible. A phenomenon, referred to as ringing effect, was observed and examined on the MC30 prototype in high finesse. The results of numerical calculations allowed us to fit measurement and estimate from them the cavity finesse as well as the mirrors' relative velocity during the resonance crossing. An empirical formula is then presented capable of determine the relative velocity from the positions of the oscillations' minima and maxima. An algorithm to guide into lock the CITF is then presented, consisting of an iterative procedure of velocity reconstruction and pulse application. A numerical calculation simulated the algorithm, the mirrors' motion, the optical response and the ADCs' process. As a result, acquisition times of the order of one second were observed: an

  10. Central- and autonomic nervous system coupling in schizophrenia

    Science.gov (United States)

    Schulz, Steffen; Bolz, Mathias; Bär, Karl-Jürgen

    2016-01-01

    The autonomic nervous system (ANS) dysfunction has been well described in schizophrenia (SZ), a severe mental disorder. Nevertheless, the coupling between the ANS and central brain activity has been not addressed until now in SZ. The interactions between the central nervous system (CNS) and ANS need to be considered as a feedback–feed-forward system that supports flexible and adaptive responses to specific demands. For the first time, to the best of our knowledge, this study investigates central–autonomic couplings (CAC) studying heart rate, blood pressure and electroencephalogram in paranoid schizophrenic patients, comparing them with age–gender-matched healthy subjects (CO). The emphasis is to determine how these couplings are composed by the different regulatory aspects of the CNS–ANS. We found that CAC were bidirectional, and that the causal influence of central activity towards systolic blood pressure was more strongly pronounced than such causal influence towards heart rate in paranoid schizophrenic patients when compared with CO. In paranoid schizophrenic patients, the central activity was a much stronger variable, being more random and having fewer rhythmic oscillatory components. This study provides a more in-depth understanding of the interplay of neuronal and autonomic regulatory processes in SZ and most likely greater insights into the complex relationship between psychotic stages and autonomic activity. PMID:27044986

  11. Comparison of control systems applied to the handling of radioactive reactor components

    International Nuclear Information System (INIS)

    Robinson, C.; Harris, E.G.; Dyer, P.C.; Williams, J.G.B.

    1985-01-01

    The first generation of nuclear power stations have individual reactors each incorporating complete facilities for servicing components and refuelling. In the later designs, each power station has two reactors which are connected by a central block. This central block contains one set of facilities to service both reactors, but to improve the station capability, some of these are to be replicated. The central block incorporates a hoist well which was used during construction for the accessing of complete components. On completion of this work, the physical size of the hoist well is such as to permit the incorporation of additional facilities if these are shown to be operationally and economically desirable. Since a number of years of power operation has elapsed, the advantages of back-fitting to existing fuel-handling facilities has been illustrated. Since the mechanical arrangements and operating procedures are substantially similar for both the original and new handling facilities, the paper will illustrate the control systems provided for each. The configuration of the system is arranged to have two channels of control which complies with the current standard requirements in the United Kingdom. These requirements are more stringent than when the existing facility was designed and constructed, as described in the relevant sections of the paper. The new system has been designed and is being manufactured to comply with the Central Electricity Generating Board standard for nuclear fuel route interlock and control systems. (author)

  12. Radiation therapy of tumours of the central nervous system

    International Nuclear Information System (INIS)

    Skolyszewski, J.

    1980-01-01

    The aim of this work is to present the principles of radiation therapy of tumours of the central nervous system, according to the experience of the Institute of Oncology in Krakow. The text was designed primarily for the radiotherapists involved in the treatment of tumours of the central nervous system, and may be used as an auxiliary textbook for those preparing for the examination in radiotherapy. (author)

  13. Development of a computer control system for the RCNP ring cyclotron

    International Nuclear Information System (INIS)

    Ogata, H.; Yamazaki, T.; Ando, A.; Hosono, K.; Itahashi, T.; Katayama, I.; Kibayashi, M.; Kinjo, S.; Kondo, M.; Miura, I.; Nagayama, K.; Noro, T.; Saito, T.; Shimizu, A.; Uraki, M.; Maruyama, M.; Aoki, K.; Yamada, S.; Kodaira, K.

    1990-01-01

    A hierarchically distributed computer control system for the RCNP ring cyclotron is being developed. The control system consists of a central computer and four subcomputers which are linked together by an Ethernet, universal device controllers which control component devices, man-machine interfaces including an operator console and interlock systems. The universal device controller is a standard single-board computer with an 8344 microcontroller and parallel interfaces, and is usually integrated into a component device and connected to a subcomputer by means of an optical-fiber cable to achieve high-speed data transfer. Control sequences for subsystems are easily produced and improved by using an interpreter language named OPELA (OPEration Language for Accelerators). The control system will be installed in March 1990. (orig.)

  14. Preliminary design of ECCO: Experimental control system which is cloud oriented

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Wei, E-mail: zhengwei@hust.edu.cn [State Key Laboratory of Advanced Electromagnetic Engineering and Technology in Huazhong University of Science and Technology, Wuhan 430074 (China); School of Electrical and Electronic Engineering in Huazhong University of Science and Technology, Wuhan 430074 (China); Hu, Feiran; Zhang, Ming; Zhang, Jing; Wan, Kuanhong; Liu, Qiang; Pan, Yuan; Zhuang, Ge [State Key Laboratory of Advanced Electromagnetic Engineering and Technology in Huazhong University of Science and Technology, Wuhan 430074 (China); School of Electrical and Electronic Engineering in Huazhong University of Science and Technology, Wuhan 430074 (China)

    2016-11-15

    Highlights: • ECCO is a self-organized and de-centralized control system software. • ECCO integrates ECCO-SDD and ECCO-REST.. • ECCO network protocol is based on HTTP protocol and RESTful design practice, implements Hypermedia, automatic discovery, and event. • ECCO is flexible, plug-and-play, and provides a series of unified toolkits. - Abstract: As the development of the Tokamak, the scale of the facility is getting bigger and bigger. It is a great challenge to design, manage and operate a control system of such big scale. So we developed a new control system software: Experimental Control System which is Cloud Oriented (ECCO). ECCO consists two parts, ECCO-SDD and ECCO-REST. ECCO-SDD is used to design, manage and describe the whole control system, configure every subsystem statically. There is a SDD editor which is a human machine interface for control system designer to design by simply drag and drop, and it can be easily extended using plug-in. The ECCO-SDD translator is used to generate different outputs. All the system design and configuration is stored in the MongoDB database using an object relational mapping dedicated designed for ECCO-SDD. ECCO-REST mainly defines a control network protocol based on HTTP RESTful service, it also implements automatic discovery using Zero-configuration (Zeroconf) networking standard. Since this protocol is based on industrial standard and transparent protocol, it is open enough and it can be easily implemented by others. ECCO-REST application is the core of ECCO-REST, it is a cross platform control software running on distributed control units just like the EPICS IOC. It can be extended by user created models. It is configured by human readable JSON file which can be generated by ECCO-SDD translator. ECCO is a self-organized and de-centralized control system software. Based on the same protocol, every part of the system can discover each other, thus the controllers which ECCO-REST application running on can

  15. Preliminary design of ECCO: Experimental control system which is cloud oriented

    International Nuclear Information System (INIS)

    Zheng, Wei; Hu, Feiran; Zhang, Ming; Zhang, Jing; Wan, Kuanhong; Liu, Qiang; Pan, Yuan; Zhuang, Ge

    2016-01-01

    Highlights: • ECCO is a self-organized and de-centralized control system software. • ECCO integrates ECCO-SDD and ECCO-REST.. • ECCO network protocol is based on HTTP protocol and RESTful design practice, implements Hypermedia, automatic discovery, and event. • ECCO is flexible, plug-and-play, and provides a series of unified toolkits. - Abstract: As the development of the Tokamak, the scale of the facility is getting bigger and bigger. It is a great challenge to design, manage and operate a control system of such big scale. So we developed a new control system software: Experimental Control System which is Cloud Oriented (ECCO). ECCO consists two parts, ECCO-SDD and ECCO-REST. ECCO-SDD is used to design, manage and describe the whole control system, configure every subsystem statically. There is a SDD editor which is a human machine interface for control system designer to design by simply drag and drop, and it can be easily extended using plug-in. The ECCO-SDD translator is used to generate different outputs. All the system design and configuration is stored in the MongoDB database using an object relational mapping dedicated designed for ECCO-SDD. ECCO-REST mainly defines a control network protocol based on HTTP RESTful service, it also implements automatic discovery using Zero-configuration (Zeroconf) networking standard. Since this protocol is based on industrial standard and transparent protocol, it is open enough and it can be easily implemented by others. ECCO-REST application is the core of ECCO-REST, it is a cross platform control software running on distributed control units just like the EPICS IOC. It can be extended by user created models. It is configured by human readable JSON file which can be generated by ECCO-SDD translator. ECCO is a self-organized and de-centralized control system software. Based on the same protocol, every part of the system can discover each other, thus the controllers which ECCO-REST application running on can

  16. What makes a control system usable? An operational viewpoint

    International Nuclear Information System (INIS)

    Clay, M.

    1990-01-01

    This report discusses the generally accepted successes and shortcomings of the various computer and hardware-based control systems at the Los Alamos Meson Physics Facility (LAMPF) from an operator's standpoint. LAMPF currently utilizes three separate control rooms that, although critically co-dependent, use distinct operating methods. The first, the Injector Control Room, which is responsible for the operation of the three ion sources, the 750 keV transport lines and the 201.25 MHz portion of the linac, uses a predominantly hardware-based control system. The second, the LANSCE Control Room, which is responsible for the operation of the Los Alamos Neutron Scattering Center, uses a graphical touch-panel interface with single-application screens as its control system. The third, the LAMPF Central Control Room, which is responsible for the overall operation of LAMPF, primarily uses a text-oriented keyboard interface with multiple applications per screen. Though each system provides generally reliable human interfacing to the enormously complex and diverse machine known as LAMPF, the operational requirements of speed, usability, and reliability are increasingly necessitating the use of a standard control system that incorporates the positive aspects of all three control systems. (orig.)

  17. The efficacy and stability of an information and communication technology-based centralized monitoring system of adherence to immunosuppressive medication in kidney transplant recipients: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Jung, Hee-Yeon; Seong, Sook Jin; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Chan-Duck; Yoon, Young-Ran; Kim, Hyung-Kee; Huh, Seung; Yoon, Se-Hee; Lee, Jong Soo; Kim, Yong-Lim

    2017-10-16

    Immunosuppression non-adherence in kidney transplant recipients (KTRs) not only increases the risk of medical intervention due to acute rejection and graft loss but burdens the socioeconomic system in the form of increased healthcare costs. An aggressive preemptive effort by healthcare professionals, geared to ensure adherence to immunosuppressants in KTRs, is significant and imperative. This study was designed as a prospective, open-label, multicenter, randomized controlled study aimed at evaluating the efficacy and stability of an information and communication technology (ICT)-based centralized monitoring system in boosting medication adherence in KTRs. One hundred fourteen KTRs registered throughout the year 2017 to 2018 are randomized into either the ICT-based centralized home monitoring system or to ambulatory follow-up. The planned follow-up duration is 6 months. The ICT-based centralized home monitoring system described consists of a smart pill box equipped with personal identification system, a home monitoring system, an electronic Case Report Form (eCRF) system, and a comprehensive clinical trial management system (CTMS). It alerts both patients and medical staff with texts and pill box alarms if there is a dosage/dosing time error or a missed dose. Medication adherence and transplant outcomes for the follow-up period are compared between the two groups, while patient satisfaction as well as the stability and cost-effectiveness of the ICT-based monitoring system are to be evaluated. This on-going study is expected to determine if consistent use of the ICT-based centralized monitoring system described could maximize mediation adherence and subsequently enhance transplant outcomes in KTRs. Further, it would lay the foundation for successful implementation of this ICT-based monitoring system for effective management of medication adherence in KTRs. ClinicalTrials.gov, Identifier: NCT03136588 . Registered on 20 April 2017.

  18. Solar central receiver reformer system for ammonia plants

    Science.gov (United States)

    1980-07-01

    An overview of a study to retrofit the Valley Nitrogen Producers, Inc., El Centro, California 600 ST/SD Ammonia Plant with Solar Central Receiver Technology is presented. The retrofit system consists of a solar central receiver reformer (SCRR) operating in parallel with the existing fossil fired reformer. Steam and hydrocarbon react in the catalyst filled tubes of the inner cavity receiver to form a hydrogen rich mixture which is the syngas feed for the ammonia production. The SCRR system will displace natural gas presently used in the fossil reformer combustion chamber.

  19. Timing system control software in the SLC

    International Nuclear Information System (INIS)

    Thompson, K.; Phinney, N.

    1985-04-01

    A new timing system that allows precision (approx.1 to 2 ns) control of the trigger times of klystrons, beam position monitors, and other devices on a pulse-to-pulse basis at up to 360 Hz is in operation in the first third of the SLAC linear accelerator. The control software is divided between a central host VAX and local Intel 8086-based microprocessor clusters. Facilities exist to set up and adjust the timing of devices or groups of devices independently for beam pulses having different destinations and purposes, which are run in an interlaced fashion during normal machine operation. Upgrading of the system is currently underway, using a new version of the Programmable Delay Unit CAMAC module to allow pipelining of timing information for three machine pulses. An overview of the current state of the system is presented in this paper, with an emphasis on software control

  20. Central and systemic haemodynamic effects of terlipressin in portal hypertensive patients

    DEFF Research Database (Denmark)

    Møller, S; Hansen, E F; Becker, U

    2000-01-01

    the acute effects of terlipressin on central and systemic haemodynamics. METHODS: Sixteen patients with alcoholic cirrhosis and portal hypertension had their systemic, central, and splanchnic haemodynamics determined at baseline and after a blind randomised bolus infusion (2 mg) of terlipressin...... vascular resistance (r=-0.52, pportal hypertensive patients without a further contraction of the central and arterial blood volume. The systemic haemodynamic...... increased by 36% (pportal pressure and hepatic blood flow decreased (17% and 29%, both pportal pressure after terlipressin was significantly related to the increase in systemic...

  1. Towards a new Mercator Observatory Control System

    Science.gov (United States)

    Pessemier, W.; Raskin, G.; Prins, S.; Saey, P.; Merges, F.; Padilla, J. P.; Van Winckel, H.; Waelkens, C.

    2010-07-01

    A new control system is currently being developed for the 1.2-meter Mercator Telescope at the Roque de Los Muchachos Observatory (La Palma, Spain). Formerly based on transputers, the new Mercator Observatory Control System (MOCS) consists of a small network of Linux computers complemented by a central industrial controller and an industrial real-time data communication network. Python is chosen as the high-level language to develop flexible yet powerful supervisory control and data acquisition (SCADA) software for the Linux computers. Specialized applications such as detector control, auto-guiding and middleware management are also integrated in the same Python software package. The industrial controller, on the other hand, is connected to the majority of the field devices and is targeted to run various control loops, some of which are real-time critical. Independently of the Linux distributed control system (DCS), this controller makes sure that high priority tasks such as the telescope motion, mirror support and hydrostatic bearing control are carried out in a reliable and safe way. A comparison is made between different controller technologies including a LabVIEW embedded system, a PROFINET Programmable Logic Controller (PLC) and motion controller, and an EtherCAT embedded PC (soft-PLC). As the latter is chosen as the primary platform for the lower level control, a substantial part of the software is being ported to the IEC 61131-3 standard programming languages. Additionally, obsolete hardware is gradually being replaced by standard industrial alternatives with fast EtherCAT communication. The use of Python as a scripting language allows a smooth migration to the final MOCS: finished parts of the new control system can readily be commissioned to replace the corresponding transputer units of the old control system with minimal downtime. In this contribution, we give an overview of the systems design, implementation details and the current status of the project.

  2. Establish Central Kitchen under HACCP Control in Food and Beverage Industry to Ensure Food Safety and Hygiene

    Directory of Open Access Journals (Sweden)

    Cuihua Qi

    2014-04-01

    Full Text Available In recent years, food safety and hygiene have been a social problem. So, it is worth studying in-depth that how to control the safety and hygiene of food and beverage. This paper proposes to establish central kitchens under HACCP control to ensure food safety and hygiene in the food and beverage industry. Considering the practical difficulties in the application of HACCP, this paper introduces the establishment of dishes HACCP system with some examples to give the reference of the food and beverage industry. Central kitchens have many advantages while HACCP is the golden standard to ensure food safety and hygiene, hence, it will ensure food safety and hygiene if both can be combined with in the use of food and beverage industry.

  3. Neuropsychological sequelae of central nervous system prophylaxis in survivors of childhood acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    Said, J.A.; Waters, B.G.; Cousens, P.; Stevens, M.M.

    1989-01-01

    We assessed neuropsychologically 106 children with acute lymphoblastic leukemia (ALL) who had all received cranial irradiation for the prevention of central nervous system (CNS) leukemia 1-13 years previously. Children were assessed for adverse late effects of their therapy, using age-appropriate Wechsler measures of overall intellectual ability and supplementary tests. Forty-five siblings near in age to the patients were tested as controls. The patients who had had the most intensive central nervous system (CNS) prophylaxis were found to have a WISC-R Full Scale IQ 17 points lower than the sibling control group. Performance IQ was more affected than verbal IQ. The patients were more easily distracted and less able to concentrate. The severity of the aftereffects was related to younger age at the time of CNS prophylaxis and to a higher dose of cranial irradiation but not to time since CNS prophylaxis. CNS prophylaxis using a combination of cranial irradiation and intrathecal methotrexate has lowered the incidence of CNS relapse in childhood ALL but is associated with considerable long-term morbidity in survivors

  4. Automatic system of tests for control equipment in combined cycle power stations; Sistema automatico de pruebas para equipos de control en centrales de ciclo combinado

    Energy Technology Data Exchange (ETDEWEB)

    Martinez M, Miguel A; Flores L, Zenon; Delgadillo V, Miguel A; Gutierrez A, Ruben [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2001-07-01

    This article deals on the Automatic System of Tests, denominated PROBADOR, used by the Gerencia de Control e Instrumentation (GCI) of the Instituto de Investigaciones Electricas (IIE)for the accomplishment of dynamic tests in laboratory, to the systems of acquisition and control developed with the electronic line SAC-IIE that are installed in the Thermoelectric Power station of Combined Cycle (CTCC) of Dos Bocas, Veracruz and Gomez Palacio, Durango, Mexico. Also the architecture, the functions that are carried out in the equipment of the System of Acquisition and control (SAC) and in the personal computer (PC) that conforms it are described, as well as the methodology used for the development of the tests. The PC constitutes Interface Man-Machine (IMM) and in the SAC equipment the simulation of the processes is made (by means of the execution of algebraic-differential equations) in the compressor, combustion chamber, gas turbine, heat recuperators, steam turbines and condenser equipment that integrate a CTCC. The equations that are used are based in the thermodynamics, flow dynamics and heat transfer; they become attached to the real process with a margin of error that is estimated in 10%. Finally, the tendencies of the PROBADOR and the technical and economic advantages are described that it has provided for the improvement in the performance of the control systems, before different situations, with no need to have the real process. [Spanish] Este articulo versa sobre el Sistema Automatico de Pruebas, denominado PROBADOR, utilizado por la Gerencia de Control e Instrumentacion (GCI) del Instituto de Investigaciones Electricas para la realizacion de pruebas dinamicas en laboratorio, a los sistemas de adquisicion y control desarrollado con la linea electronica SAC-IIE que estan instalados en las Centrales Termoelectricas de Ciclo Combinado (CTCC) de Dos Bocas, Veracruz y Gomez Palacio, Durango, Mexico. Tambien se describen la arquitectura, las funciones que se llevan

  5. CAD-model based remote handling control system for NET and JET

    International Nuclear Information System (INIS)

    Leinemann, K.; Kuehneapfel, U.; Ludwig, A.

    1989-01-01

    For maintenance work in fusion plants a supervisory control system concept was developed, which organized a close, problem-suited cooperation of man and machine, based on shared control and mutual help. The central module on the task control level of the control system is a real-time simulator based on a three-dimensional CAD-model. This simulator serves for planning and of-line programming of maintenance sequences, and, in th execution phase, for integrated viewing, combining TV and synthetic scene presentation. A first implementation of a geometric simulator and its integration in an overall control system was realized for JET. (author). 5 refs.; 7 figs

  6. Gut-central nervous system axis is a target for nutritional therapies

    Directory of Open Access Journals (Sweden)

    Pimentel Gustavo D

    2012-04-01

    Full Text Available Abstract Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the "appetite centre" and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.

  7. Commissioning the ATLAS Level-1 Central Trigger System

    CERN Document Server

    Sherman, Daniel

    2010-01-01

    The ATLAS Level-1 central trigger is a critical part of ATLAS operation. It receives the 40 MHz bunch clock from the LHC and distributes it to all sub-detectors. It initiates their read-out by forming the Level-1 Accept decision, which is based on information from the calorimeter and muon trigger processors and a variety of additional trigger inputs from detectors in the forward region. It also provides trigger summary information to the data acquisition system and the Level-2 trigger system. In this paper, we present the completion of the installed central trigger system, its performance during cosmic-ray data taking and the experience gained with triggering on the first LHC beams.

  8. DIII-D Neutral Beam control system operator interface

    International Nuclear Information System (INIS)

    Harris, J.J.; Campbell, G.L.

    1993-10-01

    A centralized graphical user interface has been added to the DIII-D Neutral Beam (NB) control systems for status monitoring and remote control applications. This user interface provides for automatic data acquisition, alarm detection and supervisory control of the four NB programmable logic controllers (PLC) as well as the Mode Control PLC. These PLCs are used for interlocking, control and status of the NB vacuum pumping, gas delivery, and water cooling systems as well as beam mode status and control. The system allows for both a friendly user interface as well as a safe and convenient method of communicating with remote hardware that formerly required interns to access. In the future, to enable high level of control of PLC subsystems, complete procedures is written and executed at the touch of a screen control panel button. The system consists of an IBM compatible 486 computer running the FIX DMACS trademark for Windows trademark data acquisition and control interface software, a Texas Instruments/Siemens communication card and Phoenix Digital optical communications modules. Communication is achieved via the TIWAY (Texas Instruments protocol link utilizing both fiber optic communications and a copper local area network (LAN). Hardware and software capabilities will be reviewed. Data and alarm reporting, extended monitoring and control capabilities will also be discussed

  9. SUBSURFACE REPOSITORY INTEGRATED CONTROL SYSTEM DESIGN

    International Nuclear Information System (INIS)

    Randle, D.C.

    2000-01-01

    , controlled, and interfaced (Section 6.2). (3) Develop a preliminary design for the overall Subsurface Repository Integrated Control System functional architecture and graphically depict the operational features of this design through a series of control system functional block diagrams (Section 6.2). (4) Develop a physical architecture that presents a viable yet preliminary physical implementation for the Subsurface Repository Integrated Control System functional architecture (Section 6.3). (5) Develop an initial concept for an overall subsurface data communications network that can be used to integrate the various control systems comprising the Subsurface Repository Integrated Control System (Section 6.4). (6) Develop a preliminary central control room design for the Subsurface Repository Integrated Control System (Section 6.5). (7) Identify and discuss the general safety-related issues and design strategies with respect to development of the Subsurface Repository Integrated Control System (Section 6.6). (8) Discuss plans for the Subsurface Repository Integrated Control System's response to off-normal operations (Section 6.7). (9) Discuss plans and strategies for developing software for the Subsurface Repository Integrated Control System (Section 6.8)

  10. Centralized environmental radiation monitoring system in JAERI

    International Nuclear Information System (INIS)

    Katagiri, H.; Kobalyashi, H.

    1993-01-01

    JAERI has continued the environmental radiation background survey and monitoring to ensure the safety of the peoples around the institute since one year before the first criticality of JRR-1 (Japan Research Reactor No.1) in August 1957. Air absorbed doses from β and γ radiation, α and β radioactivity in air and the radioactivities in environmental samples were the monitoring items. For the monitoring of β and γ radiation and α and β radioactivity in air, monitoring station and the centralized automatic environmental radiation monitoring system applying a computer were established as a new challenging monitoring system for nuclear facility, which was the first one not only in Japan but also in the would in 1960 and since then the system has been renewed two times (in 1973 and 1988) by introducing the latest technology in the fields of radiation detection and computer control at each stage. Present system renewed in 1988 was designed to prevent the interruption of monitoring due to computer troubles, communication troubles and power failures especially an instant voltage drop arisen from thunder by reflecting the experiences through the operation and maintenance of the former system. Dual telemeters whose power is constantly supplied via batteries (capable of 10 min monitoring after power failure) are equipped in the monitoring center to cope with telemeter troubles, which has operated successfully without any suspension being attributable to the power failures and telemeter troubles

  11. Dynamic optimal metabolic control theory: a cybernetic approach for modelling of the central nitrogen metabolism of S. cerevisiae

    NARCIS (Netherlands)

    Riel, van N.A.W.; Giuseppin, M.L.F.; Verrips, C.T.

    2000-01-01

    The theory of dynamic optimal metabolic control (DOMC), as developed by Giuseppin and Van Riel (Metab. Eng., 2000), is applied to model the central nitrogen metabolism (CNM) in Saccharomyces cerevisiae. The CNM represents a typical system encountered in advanced metabolic engineering. The CNM is the

  12. Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis.

    Science.gov (United States)

    Eriksson, Charlotta E; Studahl, Marie; Bergström, Tomas

    2016-06-15

    Herpes simplex encephalitis (HSE) is characterized by a pronounced inflammatory activity in the central nervous system (CNS). Here, we investigated the acute and prolonged complement system activity in HSE patients, by using enzyme-linked immunosorbent assays (ELISAs) for numerous complement components (C). We found increased cerebrospinal fluid concentrations of C3a, C3b, C5 and C5a in HSE patients compared with healthy controls. C3a and C5a concentrations remained increased also compared with patient controls. Our results conclude that the complement system is activated in CNS during HSE in the acute phase, and interestingly also in later stages supporting previous reports of prolonged inflammation. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with acute lymphocytic leukemia

    International Nuclear Information System (INIS)

    Moss, H.A.; Nannis, E.D.; Poplack, D.G.

    1981-01-01

    The effect of central nervous system prophylaxis (cranial radiation and intrathecal chemotherapy) on intellectual function was studied in 24 children with acute lymphocytic leukemia. The Wechsler Intelligence tests were administered to these children and to a sample of their healthy siblings, who served as a comparison group. The mean Full Scale lQ was 98.6 for the patients and 112.5 for the sibling controls (p less than 0.001 level). Those patients who received central nervous system preventive treatment at a young age exhibited a greater decrement in intellectual abilities than did patients who were older when they received this treatment. In contrast, leukemia patients who had not received central nervous system prophylaxis had IQs that did not differ statistically from those of their siblings. These data suggest that central nervous system prophylaxis may have an adverse effect on the intellectual capability of children with acute lymphocytic leukemia

  14. Coupled core criticality calculations with control rods located in the central reflector region

    Energy Technology Data Exchange (ETDEWEB)

    Sobhy, M [Reactor depatrment, nuclear research center, Inshaas (Egypt)

    1995-10-01

    The reactivity of a coupled core is controlled by a set of control rods distributed in the central reflector region. The reactor contains two compact cores cooled and moderated by light water. Control rods are designed to have reactivity worths sufficient to start, control and shutdown the coupled system. Each core in a coupled system is in subcritical conditions without any absorber then each core needs to the other core to fulfill nuclear chain reaction and to approach the criticality. In this case, each core is considered clean which is suitable for research reactor with low flux disturbance and better neutron economy, in addition to the advantage of disappearing the cut corner fuel baskets. This facilitate the in core fuel management with identical fuel baskets. Hot spots will disappear. This leads to a good heat transfer process. the excess reactivity and the shutdown margin are calculated for some of reflector as coupling region gives sufficient area for coupled core are calculated cost. The fluctuations of reactivity for coupled core are calculated by noise analysis technique and compared with that for rode core. The results show low reactivity perturbation associated with coupled core.

  15. Using a Nameserver to Enhance Control System Efficiency

    International Nuclear Information System (INIS)

    Joan Sage; Karen White; Matthew Bickley

    2001-01-01

    The Thomas Jefferson National Accelerator Facility control system uses a nameserver to reduce system response time and to minimize the impact of client name resolution on front-end computers. The control system is based on the Experimental Physics and Industrial Control System (EPICS), which uses name-based broadcasts to initiate data communication. By default, when EPICS process variables are requested by client applications, all front-end computers receive the broadcasts and perform name resolution processing against local channel name lists. The nameserver is used to offload the name resolution task to a single node. This processing, formerly done on all front-end computers, is now done only by the nameserver. In a control system with heavily loaded front-end computers and high peak client connection loads, a significant performance improvement is seen. This paper describes the name server in more detail, and discusses the strengths and weaknesses of making name resolution a centralized service. This work was supported by the U.S. DOE contract No. DE-AC05-84ER40150

  16. A discussion on practicable scheme for machine control system of HL-2A tokamak

    International Nuclear Information System (INIS)

    Li Qiang; Song Xianming; Jiang Chao

    2001-01-01

    This is the modified version of The Preliminary Design on the Hardware and Nets of HL-2A Tokamak. In this version, centralized control as well as the field bus communication on HL-2A Tokamak is used. The hardware components and the operational theory are introduced. The questions of practice program, extensibility, centralized control, cooperation with other subsystems and the continuous adaptation of present device are all discussed. The budget of the system is detailed. To keep the step with the overall engineering constructions of HL-2A, suggestions of the time program are presented for the system design, instrument purchases, installation, construction, user program development and the final operation processes for the machine control system of HL-2A Tokamak

  17. Computer-to-process interface in JET's control and diagnostic systems

    International Nuclear Information System (INIS)

    Fullard, K.; Dorling, S.; Van Montfoort, J.

    1987-01-01

    The JET Control and Data Acquisition System, CODAS, uses some 40,000 electrical signals to control and monitor JET's various systems. This paper describes the electronic equipment and the data transmission techniques which are used to route these signals to and from the centrally-located computers. Special emphasis has been placed on the practical aspects of building and maintaining such a large system of approaching 8,000 modules. Quantities and costs of the various classes of modules and cables are given together with an outline of the quality assurance and organisational techniques adopted

  18. System design package for the solar heating and cooling central data processing system

    Science.gov (United States)

    1978-01-01

    The central data processing system provides the resources required to assess the performance of solar heating and cooling systems installed at remote sites. These sites consist of residential, commercial, government, and educational types of buildings, and the solar heating and cooling systems can be hot-water, space heating, cooling, and combinations of these. The instrumentation data associated with these systems will vary according to the application and must be collected, processed, and presented in a form which supports continuity of performance evaluation across all applications. Overall software system requirements were established for use in the central integration facility which transforms raw data collected at remote sites into performance evaluation information for assessing the performance of solar heating and cooling systems.

  19. Earth Observation Data Quality Monitoring and Control: A Case Study of STAR Central Data Repository

    Science.gov (United States)

    Han, W.; Jochum, M.

    2017-12-01

    Earth observation data quality is very important for researchers and decision makers involved in weather forecasting, severe weather warning, disaster and emergency response, environmental monitoring, etc. Monitoring and control earth observation data quality, especially accuracy, completeness, and timeliness, is very useful in data management and governance to optimize data flow, discover potential transmission issues, and better connect data providers and users. Taking a centralized near real-time satellite data repository, STAR (Center for Satellite Applications and Research of NOAA) Central Data Repository (SCDR), as an example, this paper describes how to develop new mechanism to verify data integrity, check data completeness, and monitor data latency in an operational data management system. Such quality monitoring and control of large volume satellite data help data providers and managers improve data transmission of near real-time satellite data, enhance its acquisition and management, and overcome performance and management issues to better serve research and development activities.

  20. Decentralized control of a scalable photovoltaic (PV)-battery hybrid power system

    International Nuclear Information System (INIS)

    Kim, Myungchin; Bae, Sungwoo

    2017-01-01

    Highlights: • This paper introduces the design and control of a PV-battery hybrid power system. • Reliable and scalable operation of hybrid power systems is achieved. • System and power control are performed without a centralized controller. • Reliability and scalability characteristics are studied in a quantitative manner. • The system control performance is verified using realistic solar irradiation data. - Abstract: This paper presents the design and control of a sustainable standalone photovoltaic (PV)-battery hybrid power system (HPS). The research aims to develop an approach that contributes to increased level of reliability and scalability for an HPS. To achieve such objectives, a PV-battery HPS with a passively connected battery was studied. A quantitative hardware reliability analysis was performed to assess the effect of energy storage configuration to the overall system reliability. Instead of requiring the feedback control information of load power through a centralized supervisory controller, the power flow in the proposed HPS is managed by a decentralized control approach that takes advantage of the system architecture. Reliable system operation of an HPS is achieved through the proposed control approach by not requiring a separate supervisory controller. Furthermore, performance degradation of energy storage can be prevented by selecting the controller gains such that the charge rate does not exceed operational requirements. The performance of the proposed system architecture with the control strategy was verified by simulation results using realistic irradiance data and a battery model in which its temperature effect was considered. With an objective to support scalable operation, details on how the proposed design could be applied were also studied so that the HPS could satisfy potential system growth requirements. Such scalability was verified by simulating various cases that involve connection and disconnection of sources and loads. The

  1. EPICS: Experimental Physics and Industrial Control System

    Science.gov (United States)

    Epics Development Team

    2013-02-01

    EPICS is a set of software tools and applications developed collaboratively and used to create distributed soft real-time control systems for scientific instruments such as particle accelerators and telescopes. Such distributed control systems typically comprise tens or even hundreds of computers, networked together to allow communication between them and to provide control and feedback of the various parts of the device from a central control room, or even remotely over the internet. EPICS uses Client/Server and Publish/Subscribe techniques to communicate between the various computers. A Channel Access Gateway allows engineers and physicists elsewhere in the building to examine the current state of the IOCs, but prevents them from making unauthorized adjustments to the running system. In many cases the engineers can make a secure internet connection from home to diagnose and fix faults without having to travel to the site. EPICS is used by many facilities worldwide, including the Advanced Photon Source at Argonne National Laboratory, Fermilab, Keck Observatory, Laboratori Nazionali di Legnaro, Brazilian Synchrotron Light Source, Los Alamos National Laboratory, Australian Synchrotron, and Stanford Linear Accellerator Center.

  2. Considerations for control system software verification and validation specific to implementations using distributed processor architectures

    International Nuclear Information System (INIS)

    Munro, J.K. Jr.

    1993-01-01

    Until recently, digital control systems have been implemented on centralized processing systems to function in one of several ways: (1) as a single processor control system; (2) as a supervisor at the top of a hierarchical network of multiple processors; or (3) in a client-server mode. Each of these architectures uses a very different set of communication protocols. The latter two architectures also belong to the category of distributed control systems. Distributed control systems can have a central focus, as in the cases just cited, or be quite decentralized in a loosely coupled, shared responsibility arrangement. This last architecture is analogous to autonomous hosts on a local area network. Each of the architectures identified above will have a different set of architecture-associated issues to be addressed in the verification and validation activities during software development. This paper summarizes results of efforts to identify, describe, contrast, and compare these issues

  3. Performance of a proximity cryogenic system for the ATLAS central solenoid magnet

    CERN Document Server

    Doi, Y; Makida, Y; Kondo, Y; Kawai, M; Aoki, K; Haruyama, T; Kondo, T; Mizumaki, S; Wachi, Y; Mine, S; Haug, F; Delruelle, N; Passardi, Giorgio; ten Kate, H H J

    2002-01-01

    The ATLAS central solenoid magnet has been designed and constructed as a collaborative work between KEK and CERN for the ATLAS experiment in the LHC project The solenoid provides an axial magnetic field of 2 Tesla at the center of the tracking volume of the ATLAS detector. The solenoid is installed in a common cryostat of a liquid-argon calorimeter in order to minimize the mass of the cryostat wall. The coil is cooled indirectly by using two-phase helium flow in a pair of serpentine cooling line. The cryogen is supplied by the ATLAS cryogenic plant, which also supplies helium to the Toroid magnet systems. The proximity cryogenic system for the solenoid has two major components: a control dewar and a valve unit In addition, a programmable logic controller, PLC, was prepared for the automatic operation and solenoid test in Japan. This paper describes the design of the proximity cryogenic system and results of the performance test. (7 refs).

  4. MicroRNA expression in the adult mouse central nervous system

    DEFF Research Database (Denmark)

    Bak, Mads; Silahtaroglu, Asli; Møller, Morten

    2008-01-01

    distinct areas of the adult mouse central nervous system (CNS). Microarray profiling in combination with real-time RT-PCR and LNA (locked nucleic acid)-based in situ hybridization uncovered 44 miRNAs displaying more than threefold enrichment in the spinal cord, cerebellum, medulla oblongata, pons......RNA-related gene regulatory networks in the mammalian central nervous system. Udgivelsesdato: 2008-Mar...

  5. Role of metallothionein-III following central nervous system damage

    DEFF Research Database (Denmark)

    Carrasco, Javier; Penkowa, Milena; Giralt, Mercedes

    2003-01-01

    We evaluated the physiological relevance of metallothionein-III (MT-III) in the central nervous system following damage caused by a focal cryolesion onto the cortex by studying Mt3-null mice. In normal mice, dramatic astrogliosis and microgliosis and T-cell infiltration were observed in the area...... the inflammatory response elicited in the central nervous system by a cryoinjury, nor does it serve an important antioxidant role, but it may influence neuronal regeneration during the recovery process....

  6. A prototype system dynamic model of nuclear and radiological export controls in Central Asia and the Caucasus; enhancing the effectiveness of preventing illicit nuclear material trafficking

    International Nuclear Information System (INIS)

    Ferguston, C.D.; Ouagrham, S.B.

    2002-01-01

    An urgent need calls out for improved border security and export control systems in the Central Asian and Caucasus regions to prevent illicit nuclear and radioactive materials trafficking. Effective nuclear and radiological exports controls are essential because these regions contain numerous nuclear facilities and radioactive materials as well as lie at the crossroads between seekers and suppliers of technologies that could be employed in nuclear and radiological weapons. Porous and unprotected borders compound these concerns. Moreover, the states within these regions are struggling with forming new regulations and laws, obtaining sufficient portal monitoring equipment, training customs and border security personnel, and coordinating these activities with neighboring states. Building this infrastructure all at once can severely task any government. Thus, unsurprisingly, most of these states have inadequate export control and border security systems. To enable each state in these regions determine how to better prevent illicit nuclear and radiological materials trafficking, the authors have developed a prototype system dynamics model focused on evaluating and improving of effectiveness of export controls. System dynamics modeling, a management tool that grew out of the field of system engineering and nonlinear dynamics, uses two structures: causal loop diagrams and stock and flow diagrams. The former shows how endogenous systematic factors interact with each other to produce feedback mechanisms that results in either balancing or reinforcing loops. A classic example is a arms race, modeled as a vicious cycle or reinforcing loop. In addition to interacting with each other, causal loops influence the flow of stock, which is material concern. In the export control system dynamics model, the stock represents nuclear and radioactive materials. System dynamics modelling is an iterative process that is continually modified by user input. Therefore, export control

  7. Direct numerical control of machine tools in a nuclear research center by the CAMAC system

    International Nuclear Information System (INIS)

    Zwoll, K.; Mueller, K.D.; Becks, B.; Erven, W.; Sauer, M.

    1977-01-01

    The production of mechanical parts in research centers can be improved by connecting several numerically controlled machine tools to a central process computer via a data link. The CAMAC Serial Highway with its expandable structure yields an economic and flexible system for this purpose. The CAMAC System also facilitates the development of modular components controlling the machine tools itself. A CAMAC installation controlling three different machine tools connected to a central computer (PDP11) via the CAMAC Serial Highway is described. Besides this application, part of the CAMAC hardware and software can also be used for a great variety of scientific experiments

  8. Pharmacotherapy for Adults with Tumors of the Central Nervous System

    OpenAIRE

    Schor, Nina F.

    2008-01-01

    Tumors of the adult central nervous system are among the most common and most chemoresistant neoplasms. Malignant tumors of the brain and spinal cord collectively account for approximately 1.3% of all cancers and 2.2% of all cancer-related deaths. Novel pharmacological approaches to nervous system tumors are urgently needed. This review presents the current approaches and challenges to successful pharmacotherapy of adults with malignant tumors of the central nervous system and discusses novel...

  9. Bioengineered Hydrogel to Inhibit Post-Traumatic Central Nervous System Scarring

    Science.gov (United States)

    2016-10-01

    AWARD NUMBER: W81XWH-14-1-0586 TITLE: Bioengineered Hydrogel to Inhibit Post-Traumatic Central Nervous System Scarring PRINCIPAL...Hydrogel to Inhibit Post-Traumatic Central Nervous System Scarring 5a. CONTRACT NUMBER W81XWH-14-1-0586 5b. GRANT NUMBER W81XWH- 14-1-0586 5c...barriers that prevent the optimal delivery of biologics and cells to the injured nervous system . A significant problem is the formation of scar tissue

  10. Financial Crisis and the Central Bank System

    Directory of Open Access Journals (Sweden)

    RICHARD POSPISIL

    2015-05-01

    Full Text Available The financial crisis that began in 2008 gradually developed into a global economic crisis and continues to this day. There is a lot of causes standing behind the creation, depth and process of the crisis, which is the deepest since the thirties of last centrury. One of the reasons can be found in the risky behavior of commercial banks, especially in the excessive lending of credits and mortgages. Its share on the financial crisis have central banks and their failure as the financial supervisory authority. But there is a lot of another causes of failures in the commercial banking system. And some of the causes lies outside the banking system and monetary policy. Its share of the blame has also become from state and its expenditure on the social policy.This article analyzes the role of the commercial banking system and the central banks on the financial crisis including prevention options and measures.

  11. FINANCIAL CRISIS AND THE CENTRAL BANK SYSTEM

    Directory of Open Access Journals (Sweden)

    Richard POSPISIL

    2015-07-01

    Full Text Available The financial crisis that began in 2008 gradually developed into a global economic crisis and continues to this day. There is a lot of causes standing behind the creation, depth and process of the crisis, which is the deepest since the thirties of last centrury. One of the reasons can be found in the risky behavior of commercial banks, especially in the excessive lending of credits and mortgages. Its share on the financial crisis have central banks and their failure as the financial supervisory authority. But there is a lot of another causes of failures in the commercial banking system. And some of the causes lies outside the banking system and monetary policy. Its share of the blame has also become from state and its expenditure on the social policy.This article analyzes the role of the commercial banking system and the central banks on the financial crisis including prevention options and measures.

  12. alpha-MSH in systemic inflammation. Central and peripheral actions.

    Science.gov (United States)

    Catania, A; Delgado, R; Airaghi, L; Cutuli, M; Garofalo, L; Carlin, A; Demitri, M T; Lipton, J M

    1999-10-20

    Until recently, inflammation was believed to arise from events taking place exclusively in the periphery. However, it is now clear that central neurogenic influences can either enhance or modulate peripheral inflammation. Therefore, it should be possible to improve treatment of inflammation by use of antiinflammatory agents that reduce peripheral host responses and inhibit proinflammatory signals in the central nervous system (CNS). One such strategy could be based on alpha-melanocyte stimulating hormone (alpha-MSH). Increases in circulating TNF-alpha and nitric oxide (NO), induced by intraperitoneal administration of endotoxin in mice, were modulated by central injection of a small concentration of alpha-MSH. Inducible nitric oxide synthase (iNOS) activity and iNOS mRNA in lungs and liver were likewise modulated by central alpha-MSH. Increase in lung myeloperoxidase (MPO) activity was significantly less in lungs of mice treated with central alpha-MSH. Proinflammatory agents induced by endotoxin were significantly greater after blockade of central alpha-MSH. The results suggest that antiinflammatory influences of neural origin that are triggered by alpha-MSH could be used to treat systemic inflammation. In addition to its central influences, alpha-MSH has inhibitory effects on peripheral host cells, in which it reduces release of proinflammatory mediators. alpha-MSH reduces chemotaxis of human neutrophils and production of TNF-alpha, neopterin, and NO by monocytes. In research on septic patients, alpha-MSH inhibited release of TNF-alpha, interleukin-1 beta (IL-1 beta), and interleukin-8 (IL-8) in whole blood samples in vitro. Combined central and peripheral influences can be beneficial in treatment of sepsis.

  13. Computer control of the TFTR tritium storage and delivery system

    International Nuclear Information System (INIS)

    Youssef, N.; Phillips, H.; Yemin, L.; Dong, J.; Pierce, C.

    1980-01-01

    The Tritium Storage and Delivery System (TSDS) will deliver to the torus the required tritium gas in precisely controlled injection profiles. This system will utilize advanced Central Instrumentation, Control and Data Acquisition (CICADA) computer-control techniques, in normal and malfunction-recovery modes of operation. The control scheme of the TSDS is built of three main control scenarios. An operating mode defines the permissives, sequence and path of a process during each scenario. The computerized control of the TSDS has four distinct advantages: (1) versatile control with fast response times both for tritium gas generation and for gas injection into the torus; (2) ease of selecting the proper operating modes of a control scenario, (3) ease of operation without disturbing the multiple levels of containment, and (4) simple fast trouble shooting of system malfunction utilizing programmed procedures and on-line diagnosis. The TSDS has both remote nd local control capability

  14. Computer control system of the superconducting SR-light source ''Aurora''

    International Nuclear Information System (INIS)

    Yamada, H.

    1989-01-01

    The Aurora is a compact SR-light system optimized for x-ray lithography. The system includes a superconducting electron storage ring, a 150-MeV race track microtron as an injector, and light beamlines. The SR-ring features a single magnet body, in which the 650-MeV electron beam orbits a true circular trajectory of 1 m diameter. The computer control system developed for Aurora has a three-level hierarchical architecture. The top level is the Central Intelligence System, and the second an Autonomic Control System (ACS). The bottom is an assembly of distributed local controllers linked to the ACS level through optical fibers. This system provides fully automatic and remote operation, and a powerful machine study capability through the associated man--machine console and the interpretive operation language

  15. Computer control system of the superconducting SR-light source ``Aurora''

    Science.gov (United States)

    Yamada, Hironari

    1989-07-01

    The Aurora is a compact SR-light system optimized for x-ray lithography. The system includes a superconducting electron storage ring, a 150-MeV race track microtron as an injector, and light beamlines. The SR-ring features a single magnet body, in which the 650-MeV electron beam orbits a true circular trajectory of 1 m diameter. The computer control system developed for Aurora has a three-level hierarchical architecture. The top level is the Central Intelligence System, and the second an Autonomic Control System (ACS). The bottom is an assembly of distributed local controllers linked to the ACS level through optical fibers. This system provides fully automatic and remote operation, and a powerful machine study capability through the associated man-machine console and the interpretive operation language.

  16. Effects of Brazilian scorpion venoms on the central nervous system.

    Science.gov (United States)

    Nencioni, Ana Leonor Abrahão; Neto, Emidio Beraldo; de Freitas, Lucas Alves; Dorce, Valquiria Abrão Coronado

    2018-01-01

    In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus , T. bahiensis , T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus , T. silvestres, T. brazilae , T. confluens , T. costatus , T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system. On the other hand, some evidence show the participation of the central nervous system and inflammatory response in the process. The participation of the central nervous system in envenoming has always been questioned. Some authors claim that the central effects would be a consequence of peripheral stimulation and would be the result, not the cause, of the envenoming process. Because, they say, at least in adult individuals, the venom would be unable to cross the blood-brain barrier. In contrast, there is some evidence showing the direct participation of the central nervous system in the envenoming process. This review summarizes the major findings on the effects of Brazilian scorpion venoms on the central nervous system, both clinically and experimentally. Most of the studies have been performed with T. serrulatus and T. bahiensis . Little information is available regarding the other Brazilian Tityus species.

  17. [Parasitic diseases of the central nervous system].

    Science.gov (United States)

    Schmutzhard, E

    2010-02-01

    Central nervous system infections and infestations by protozoa and helminths constitute a problem of increasing importance throughout all of central European and northern/western countries. This is partially due to the globalisation of our society, tourists and business people being more frequently exposed to parasitic infection/infestation in tropical countries than in moderate climate countries. On top of that, migrants may import chronic infestations and infections with parasitic pathogens, eventually also--sometimes exclusively--involving the nervous system. Knowledge of epidemiology, initial clinical signs and symptoms, diagnostic procedures as well as specific chemotherapeutic therapies and adjunctive therapeutic strategies is of utmost important in all of these infections and infestations of the nervous systems, be it by protozoa or helminths. This review lists, mainly in the form of tables, all possible infections and infestations of the nervous systems by protozoa and by helminths. Besides differentiating parasitic diseases of the nervous system seen in migrants, tourists etc., it is very important to have in mind that disease-related (e.g. HIV) or iatrogenic immunosuppression has led to the increased occurrence of a wide variety of parasitic infections and infestations of the nervous system (e. g. babesiosis, Chagas disease, Strongyloides stercoralis infestation, toxoplasmosis, etc.).

  18. Timing, Trigger and Control Systems for LHC Detectors

    CERN Multimedia

    2002-01-01

    \\\\ \\\\At the LHC, precise bunch-crossing clock and machine orbit signals must be broadcast over distances of several km from the Prevessin Control Room to the four experiment areas and other destinations. At the LHC experiments themselves, quite extensive distribution systems are also required for the transmission of timing, trigger and control (TTC) signals to large numbers of front-end electronics controllers from a single location in the vicinity of the central trigger processor. The systems must control the detector synchronization and deliver the necessary fast signals and messages that are phased with the LHC clock, orbit or bunch structure. These include the bunch-crossing clock, level-1 trigger decisions, bunch and event numbers, as well as test signals and broadcast commands. A common solution to this TTC system requirement is expected to result in important economies of scale and permit a rationalization of the development, operational and support efforts required. LHC Common Project RD12 is developi...

  19. An exact solution procedure for multi-item two-echelon spare parts inventory control problem with batch ordering in the central warehouse

    NARCIS (Netherlands)

    Topan, E.; Bayindir, Z.P.; Tan, T.

    2009-01-01

    We consider a multi-item two-echelon inventory system in which the central warehouse operates under a (Q; R) policy, and the local warehouses implement basestock policy. An exact solution procedure is proposed to find the inventory control policy parameters that minimize the system-wide inventory

  20. 78 FR 63159 - Amendment to Certification of Nebraska's Central Filing System

    Science.gov (United States)

    2013-10-23

    ..., Raspberries, Rye, Seed crops, Sheep & Lambs, Silage, Sorghum Grain, Soybeans, Squash, Strawberries, Sugar....usda.gov ). Farm products covered by a State's central filing system are also identified through the GIPSA Web site. The Nebraska central filing system covers specified farm products. We originally...

  1. Development of new plant monitoring and control system with advanced man-machine interfaces NUCAMM-80

    International Nuclear Information System (INIS)

    Sato, Hideyuki; Joge, Toshio; Miyake, Masao; Kishi, Shoichi

    1981-01-01

    BWR type nuclear power stations are the typical plants adopting central monitoring system in view of the size of the scale of system and the prevention of radiation exposure. Central control boards became large as much informations and many operating tools are concentrated on them. Recently, the unit capacity has increased, and the safety has been strengthened, therefore more improvement of the man-machine interface is required concerning the monitoring of plant operation. Hitachi Ltd. developed the central monitoring and control system for nuclear power stations ''NUCAMM-80'', concentrating related fundamental techniques such as the collection of plant informations, the expansion of automatic operation, the ergonomic re-evaluation of the arrangement of panels and subsystems, and the effective use of functional hardwares such as controlling computers and cathode ray tubes, for the purposes of improving the reliability of plant operation and the rate of operation, the reduction of the burden of operators and drastic labor saving. The fundamental policy of the development, the construction of the system, panel layout and the collection of informations, the development of the system for plant automation, the development of plant diagnosis and prevention systems, computer system and the merits of this system are described. (Kako, I.)

  2. Financial management systems under decentralization and their effect on malaria control in Uganda.

    Science.gov (United States)

    Kivumbi, George W; Nangendo, Florence; Ndyabahika, Boniface Rutagira

    2004-01-01

    A descriptive case study with multiple sites and a single level of analysis was carried out in four purposefully selected administrative districts of Uganda to investigate the effect of financial management systems under decentralization on malaria control. Data were primarily collected from 36 interviews with district managers, staff at health units and local leaders. A review of records and documents related to decentralization at the central and district level was also used to generate data for the study. We found that a long, tedious, and bureaucratic process combined with lack of knowledge in working with new financial systems by several actors characterized financial flow under decentralization. This affected the timely use of financial resources for malaria control in that there were funds in the system that could not be accessed for use. We were also told that sometimes these funds were returned to the central government because of non-use due to difficulties in accessing them and/or stringent conditions not to divert them to other uses. Our data showed that a cocktail of bureaucratic control systems, corruption and incompetence make the financial management system under decentralization counter-productive for malaria control. The main conclusion is that good governance through appropriate and efficient financial management systems is very important for effective malaria control under decentralization.

  3. Drive Control System for Pipeline Crawl Robot Based on CAN Bus

    International Nuclear Information System (INIS)

    Chen, H J; Gao, B T; Zhang, X H; Deng, Z Q

    2006-01-01

    Drive control system plays important roles in pipeline robot. In order to inspect the flaw and corrosion of seabed crude oil pipeline, an original mobile pipeline robot with crawler drive unit, power and monitor unit, central control unit, and ultrasonic wave inspection device is developed. The CAN bus connects these different function units and presents a reliable information channel. Considering the limited space, a compact hardware system is designed based on an ARM processor with two CAN controllers. With made-to-order CAN protocol for the crawl robot, an intelligent drive control system is developed. The implementation of the crawl robot demonstrates that the presented drive control scheme can meet the motion control requirements of the underwater pipeline crawl robot

  4. Drive Control System for Pipeline Crawl Robot Based on CAN Bus

    Energy Technology Data Exchange (ETDEWEB)

    Chen, H J [Department of Electrical Engineering, Harbin Institute of Technology Harbin, Heilongjiang, 150001 (China); Gao, B T [Department of Electrical Engineering, Harbin Institute of Technology Harbin, Heilongjiang, 150001 (China); Zhang, X H [Department of Electrical Engineering, Harbin Institute of Technology Harbin, Heilongjiang, 150001 (China); Deng, Z Q [School of Mechanical Engineering, Harbin Institute of Technology Harbin, Heilongjiang, 150001 (China)

    2006-10-15

    Drive control system plays important roles in pipeline robot. In order to inspect the flaw and corrosion of seabed crude oil pipeline, an original mobile pipeline robot with crawler drive unit, power and monitor unit, central control unit, and ultrasonic wave inspection device is developed. The CAN bus connects these different function units and presents a reliable information channel. Considering the limited space, a compact hardware system is designed based on an ARM processor with two CAN controllers. With made-to-order CAN protocol for the crawl robot, an intelligent drive control system is developed. The implementation of the crawl robot demonstrates that the presented drive control scheme can meet the motion control requirements of the underwater pipeline crawl robot.

  5. Is Ghrelin Synthesized in the Central Nervous System?

    Science.gov (United States)

    Cabral, Agustina; López Soto, Eduardo J; Epelbaum, Jacques; Perelló, Mario

    2017-03-15

    Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin could also be synthesized in some brain regions, such as the hypothalamus. However, evidences of neuronal production of ghrelin have been inconsistent and, as a consequence, it is still as a matter of debate if ghrelin can be centrally produced. Here, we provide a comprehensive review and discussion of the data supporting, or not, the notion that the mammalian central nervous system can synthetize ghrelin. We conclude that no irrefutable and reproducible evidence exists supporting the notion that ghrelin is synthetized, at physiologically relevant levels, in the central nervous system of adult mammals.

  6. Is Ghrelin Synthesized in the Central Nervous System?

    Directory of Open Access Journals (Sweden)

    Agustina Cabral

    2017-03-01

    Full Text Available Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a, and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin could also be synthesized in some brain regions, such as the hypothalamus. However, evidences of neuronal production of ghrelin have been inconsistent and, as a consequence, it is still as a matter of debate if ghrelin can be centrally produced. Here, we provide a comprehensive review and discussion of the data supporting, or not, the notion that the mammalian central nervous system can synthetize ghrelin. We conclude that no irrefutable and reproducible evidence exists supporting the notion that ghrelin is synthetized, at physiologically relevant levels, in the central nervous system of adult mammals.

  7. CT findings of central nervous system in congenital syphilis infant

    International Nuclear Information System (INIS)

    Yang Cheng; Yang Xinghui; Wang Man

    2005-01-01

    Objective: To investigate the CT features of the central nervous system in congenital syphilis infant. Methods: CT findings of central nervous system in 11 infants with clinically proved congenital syphilis were analyzed retrospectively. Results: CT findings in 10 syphilis neonates were diffuse hypodense lesions in the white matter, with subarachnoid and intra-encephalic hemorrhage in 3 and 1 cases, respectively. One 2-month-old syphilis infant case and 5 cases of follow-up after 45 days to 6 months of treatment demonstrated bilateral widened sulci and cistern with enlarged ventricles in 3 of them. Conclusion: CT findings of the central nervous system in congenital syphilis infant are similar to those of hypoxic-ischemic encephalopathy in neonates, and extra-encephalic hydrocephalus or brain hypogenesis ensues later on. (authors)

  8. Geologic characterization of Cuvette Centrale petroleum systems Congo-DRC

    Energy Technology Data Exchange (ETDEWEB)

    Vicentelli, Maria Gabriela C.; Barbosa, Mauro; Rezende, Nelio G.A.M. [HRT Petroleum, Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The Cuvette Centrale is an almost unexplored basin, which contains some petroleum system elements that indicate the presence of hydrocarbons. In this sense; this paper presents an exploratory alternative for this intracratonic basin. The interpretation of the limited gravimetric, magnetometric, geochemical and seismic available data allowed the identification of many huge structural features and also some areas with hydrocarbon potential for stratigraphic traps. The presence of several oil and gas seeps widespread around the Busira and Lokoro sub-basins indicate that at least one active petroleum system exist in the basin. Despite only four wells have been drilled in the basin, one of them presented oil shows during drilling. Geological correlations between Brazilian Paleozoic basins and Cuvette Centrale sedimentary sequences permitted to conclude that Cambro-Ordovician and Siluro-Devonian source rocks must be present and active in the Cuvette Centrale basin. The tectono-stratigraphic evolution history of the Cuvette Centrale from Neo proterozoic to Recent times shows extensional and compressional/transpressional alternating phases along the geological time. The most confident petroleum system expected in the Cuvette Centrale is characterized by the Cambrian Mamungi shale - source rock - and the Cambro-Ordovician. Upper Arenaceous Sequence - reservoirs, as observed in the MBandaka and Gilson wells and confirmed by surface geology in outcrops. Besides, other potential petroleum systems are expected to occur in the basin. One is characterized by the Neo proterozoic Itury Group source rock and reservoirs in the mature/over mature stage, the others are the Siluro-Devonian and Cretaceous source rocks and reservoirs, expected to occur with better maturity conditions only in the deeper parts of the basin. (author)

  9. Clinical trial aims to study immunotherapy for central nervous system tumors | Center for Cancer Research

    Science.gov (United States)

    A new clinical trial aims to determine whether nivolumab, an immune checkpoint inhibitor, can improve control of cancer for patients with several types of tumors of the central nervous system (CNS). The CNS is composed of the brain and spinal cord and the cause of most CNS tumors in adults is unknown. Learn more...

  10. Control System for ATLAS TileCal HVRemote boards

    CERN Document Server

    AUTHOR|(SzGeCERN)739751; The ATLAS collaboration; Gurriana, Luis; Oleiro Seabra, Luis Filipe; Evans, Guiomar; Gomes, Agostinho; Maio, Amelia; Pinto Silva Rato, Catia Sofia; Almendra Sabino, Joao Maria; Augusto, Jose

    2017-01-01

    One of the proposed solutions for upgrading the high voltage (HV) system of TileCal, the ATLAS central hadron calorimeter, consists in removing the HV regulation boards from the detector and deploying them in a low-radiation room where there is permanent access for maintenance. This option requires many ∼100 m long HV cables but removes the requirement of radiation hard boards. This solution simplifies the control system of the HV regulation cards (called HVRemote). It consists of a Detector Control System (DCS) node linked to 256 HVRemote boards through a tree of Ethernet connections. Each HVRemote includes a smart Ethernet transceiver for converting data and commands from the DCS into serial peripheral interface (SPI) signals routed to SPI-capable devices in the HVRemote. The DCS connection to the transceiver and the control of some SPI-capable devices via Ethernet has been tested successfully. A test board (HVRemote-Ctrl) with the interfacing sub-system of the HVRemote was fabricated. It is being tested ...

  11. Startup of the experimental physics industrial control system at NSTX

    International Nuclear Information System (INIS)

    Sichta, P.; Dong, J.

    1999-01-01

    The Experimental Physics Industrial Control System (EPICS) is a set of software which is being used as the basis of the National Spherical Torus Experiment's (NSTX) Process Control System, a major element of the NSTX's Central Instrumentation and Control System. EPICS is a result of a co-development effort started by several US Department of Energy National Laboratories. EPICS is actively supported through an international collaboration made up of government and industrial users. EPICS' good points include portability, scalability, and extensibility. A drawback for small experiments is that a wide range of software skills are necessary to get the software tools running for the process engineers. The authors' experience in designing, developing, operating, and maintaining NSTX's EPICS (system) will be reviewed

  12. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway

    Science.gov (United States)

    Pavlov, Valentin A.; Parrish, William R.; Rosas-Ballina, Mauricio; Ochani, Mahendar; Puerta, Margot; Ochani, Kanta; Chavan, Sangeeta; Al-Abed, Yousef; Tracey, Kevin J.

    2015-01-01

    The excessive release of cytokines by the immune system contributes importantly to the pathogenesis of inflammatory diseases. Recent advances in understanding the biology of cytokine toxicity led to the discovery of the “cholinergic anti-inflammatory pathway,” defined as neural signals transmitted via the vagus nerve that inhibit cytokine release through a mechanism that requires the alpha7 subunit-containing nicotinic acetylcholine receptor (α7nAChR). Vagus nerve regulation of peripheral functions is controlled by brain nuclei and neural networks, but despite considerable importance, little is known about the molecular basis for central regulation of the vagus nerve-based cholinergic anti-inflammatory pathway. Here we report that brain acetylcholinesterase activity controls systemic and organ specific TNF production during endotoxemia. Peripheral administration of the acetylcholinesterase inhibitor galantamine significantly reduced serum TNF levels through vagus nerve signaling, and protected against lethality during murine endotoxemia. Administration of a centrally-acting muscarinic receptor antagonist abolished the suppression of TNF by galantamine, indicating that suppressing acetylcholinesterase activity, coupled with central muscarinic receptors, controls peripheral cytokine responses. Administration of galantamine to α7nAChR knockout mice failed to suppress TNF levels, indicating that the α7nAChR-mediated cholinergic anti-inflammatory pathway is required for the anti-inflammatory effect of galantamine. These findings show that inhibition of brain acetylcholinesterase suppresses systemic inflammation through a central muscarinic receptor-mediated and vagal- and α7nAChR-dependent mechanism. Our data also indicate that a clinically used centrally-acting acetylcholinesterase inhibitor can be utilized to suppress abnormal inflammation to therapeutic advantage. PMID:18639629

  13. Sjogrens Syndrome Presenting with Central Nervous System Involvement

    Directory of Open Access Journals (Sweden)

    Tülay Terzi

    2012-01-01

    Full Text Available Sjogren’s syndrome is a slowly progressive autoimmune disease. Neurological involvement occurs in approximately 20-25% cases in Sjogren’s syndrome. 87% of the neurological involvement is peripheral nervous system, almost 13% in the form of central nervous system involvement. Affected central nervous system may show similar clinical and radiological findings as in multiple sclerosis (MS. In this paper, a 43-year-old patient is discussed who was referred with the complaint of dizziness, there was MS- like lesions in brain imaging studies and was diagnosed with Sjogren’s syndrome. MS- like clinical and radiologic tables can be seen, albeit rarely in Sjogren’s syndrome. In these cases, early diagnosis and early treatment for the sjögren has a great importance for the prognosis of the disease.

  14. Phase transitions in distributed control systems with multiplicative noise

    Science.gov (United States)

    Allegra, Nicolas; Bamieh, Bassam; Mitra, Partha; Sire, Clément

    2018-01-01

    Contemporary technological challenges often involve many degrees of freedom in a distributed or networked setting. Three aspects are notable: the variables are usually associated with the nodes of a graph with limited communication resources, hindering centralized control; the communication is subject to noise; and the number of variables can be very large. These three aspects make tools and techniques from statistical physics particularly suitable for the performance analysis of such networked systems in the limit of many variables (analogous to the thermodynamic limit in statistical physics). Perhaps not surprisingly, phase-transition like phenomena appear in these systems, where a sharp change in performance can be observed with a smooth parameter variation, with the change becoming discontinuous or singular in the limit of infinite system size. In this paper, we analyze the so called network consensus problem, prototypical of the above considerations, that has previously been analyzed mostly in the context of additive noise. We show that qualitatively new phase-transition like phenomena appear for this problem in the presence of multiplicative noise. Depending on dimensions, and on the presence or absence of a conservation law, the system performance shows a discontinuous change at a threshold value of the multiplicative noise strength. In the absence of the conservation law, and for graph spectral dimension less than two, the multiplicative noise threshold (the stability margin of the control problem) is zero. This is reminiscent of the absence of robust controllers for certain classes of centralized control problems. Although our study involves a ‘toy’ model, we believe that the qualitative features are generic, with implications for the robust stability of distributed control systems, as well as the effect of roundoff errors and communication noise on distributed algorithms.

  15. Multiple myeloma and central nervous system involvement: experience of a Brazilian center

    Directory of Open Access Journals (Sweden)

    Ana Luiza Miranda Silva Dias

    2018-01-01

    Full Text Available Introduction: The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse. Methods: This retrospective cohort study reviewed data from medical records of patients followed up at the Gammopathy Outpatient Clinic of Santa Casa de Misericórdia de São Paulo from January 2008 to December 2016. Results: Twenty patients were included, with a median follow-up of 33.5 months after central nervous system infiltration. The prevalence was 7%. The median age at diagnosis of multiple myeloma was 56.1 years, with 70% of participants being female. Sixteen patients had central nervous system infiltration at diagnosis of multiple myeloma. Seventeen patients had exclusive osteodural lesions and three had infiltrations of the leptomeninge, of which one had exclusive involvement and two had associated osteodural lesions. The median overall survival was 40.3 months after central nervous system involvement. The median overall survival in the group with central nervous system infiltration at relapse was 7.4 months. The patients with leptomeningeal involvement had a median overall survival of 5.8 months. Conclusion: Central nervous system infiltration is a rare condition, but it should be considered as a possibility in patients with multiple myeloma and neurological symptoms. The best treatment regimen for this condition remains unknown and, in most cases, the prognosis is unfavorable. Keywords: Central nervous system, Multiple myeloma, Radiotherapy, Chemotherapy, Prognosis

  16. The family house control system based on Raspberry Pi

    Directory of Open Access Journals (Sweden)

    Sysala Tomas

    2017-01-01

    Full Text Available The article deals with the design and implementation of a smart household based on simple wireless modules, which are monitoring (collecting data and controlling smart household supporting devices. The central unit processes measured parameters, and in relation to resulting values, a pre-set action is performed. Those actions variety can be configured by user via the user interface so that a set of smart rules for reaction on by household devices generated stimuli or problems can be created. That all together composes a control system based on Raspberry Pi, which manages indoor and outdoor temperature measurement, the lighting control, RF transmitter, jalousie, motion sensor control etc. There is a GUI for a PC and for a mobile phone as a part of that system.

  17. Thiophene Scaffold as Prospective Central Nervous System Agent: A Review.

    Science.gov (United States)

    Deep, Aakash; Narasimhan, Balasubramanian; Aggarwal, Swati; Kaushik, Dhirender; Sharma, Arun K

    2016-01-01

    Heterocyclic compounds are extensively dispersed in nature and are vital for life. Various investigational approaches towards Structural Activity Relationship that focus upon the exploration of optimized candidates have become vastly important. Literature studies tell that for a series of compounds that are imperative in industrial and medicinal chemistry, thiophene acts as parent. Among various classes of heterocyclic compounds that have potential central nervous system activity, thiophene is the most important one. In the largely escalating chemical world of heterocyclic compounds showing potential pharmacological character, thiophene nucleus has been recognized as the budding entity. Seventeen Papers were included in this review article to define the central nervous system potential of thiophene. This review article enlightens the rationalized use and scope of thiophene scaffold as novel central nervous system activity such as anticonvulsant, acetylcholinesterase inhibitor, cyclin-dependent kinase 5 (cdk5/p25) inhibitors, CNS depressant, capability to block norepinephrine, serotonin and dopamine reuptake by their respective transporters etc. The Finding of this review confirm the importance of thiophene scaffold as potential central nervous system agents. From this outcome, ideas for future molecular modifications leading to the novel derivatives with better constructive pharmacological potential may be derived.

  18. Focal lesions in the central nervous system: stereotaxic radioneurosurgery

    International Nuclear Information System (INIS)

    Fabrikant, J.I.; Budinger, T.f.; Hosobuchi, Y.; Born, J.L.; Tobias, C.A.

    1981-01-01

    The application of heavy-ion beams for fundamental and applied brain research has unusual potential. Methods are being developed in our laboratory for producing focal lesions in the central nervous system (e.g., the hypothalamus, thalamus, pituitary gland) to investigate nerve pathways and neuroendocrine responses, and for treating certain pathological disorders of the brain with stereotaxic Bragg peak heavy-ion radiosurgery. Studies in animals are demonstrating the value of this neuroscience tool for investigating mammalian brain response to induction of discrete focal lesions in the hypothalamus or in the cerebral cortex. These studies are also elucidating the neuroendocrinological response follwing ablation of various portions of the midbrain, without requiring complex neurosurgical preparations. Clinical studies are demonstrating the feasibility of stereotaxic neurological radiosurgery for treating certain inoperable vascular disorders of the brain [e.g., arteriovenous malformations (AVM), internal carotid artery-cavernous sinus fistulas and other cerebrovascular disorders] in patients who are already demonstrating progressive neurological deficit. Further applications of focal lesion production with the Bragg ionization peak can be extended to include localized radiation to centers of the brain and spinal cord for treatment of such disorders as Parkinson's disease, pituitary microadenomas, acoustic neuromas, and the control of pain. The eventual application of radioactive beams will provide accurate localization of the stopping points of the beam, thereby making it feasible to stop the beam accurately at a defined depth within the central nervous system

  19. Distributed model predictive control for constrained nonlinear systems with decoupled local dynamics.

    Science.gov (United States)

    Zhao, Meng; Ding, Baocang

    2015-03-01

    This paper considers the distributed model predictive control (MPC) of nonlinear large-scale systems with dynamically decoupled subsystems. According to the coupled state in the overall cost function of centralized MPC, the neighbors are confirmed and fixed for each subsystem, and the overall objective function is disassembled into each local optimization. In order to guarantee the closed-loop stability of distributed MPC algorithm, the overall compatibility constraint for centralized MPC algorithm is decomposed into each local controller. The communication between each subsystem and its neighbors is relatively low, only the current states before optimization and the optimized input variables after optimization are being transferred. For each local controller, the quasi-infinite horizon MPC algorithm is adopted, and the global closed-loop system is proven to be exponentially stable. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  20. An application-layer based centralized information access control for VPN

    Institute of Scientific and Technical Information of China (English)

    OUYANG Kai; ZHOU Jing-li; XIA Tao; YU Sheng-sheng

    2006-01-01

    With the rapid development of Virtual Private Network (VPN), many companies and organizations use VPN to implement their private communication. Traditionally, VPN uses security protocols to protect the confidentiality of data, the message integrity and the endpoint authentication. One core technique of VPN is tunneling, by which clients can access the internal servers traversing VPN. However, the tunneling technique also introduces a concealed security hole. It is possible that ifone vicious user can establish tunneling by the VPN server, he can compromise the internal servers behind the VPN server. So this paper presents a novel Application-layer based Centralized Information Access Control (ACIAC) for VPN to solve this problem.To implement an efficient, flexible and multi-decision access control model, we present two key techniques to ACIAC-the centralized management mechanism and the stream-based access control. Firstly, we implement the information center and the constraints/events center for ACIAC. By the two centers, we can provide an abstract access control mechanism, and the material access control can be decided dynamically by the ACIAC's constraint/event mechanism. Then we logically classify the VPN communication traffic into the access stream and the data stream so that we can tightly couple the features of VPN communication with the access control model. We also provide the design of our ACIAC prototype in this paper.

  1. Postural control and central motor pathway involvement in type 2 ...

    African Journals Online (AJOL)

    Mona Mokhtar El Bardawil

    2013-04-18

    Apr 18, 2013 ... Postural control and central motor pathway involvement in type 2 .... with a high power 90 mm circular coil, capable of generating. 2 T maximum field ..... advanced glycation end products, oxidative damage and microvascular ...

  2. Study of global control of VIRGO Central Interferometer

    International Nuclear Information System (INIS)

    Matone, Luca

    1999-01-01

    The VIRGO project for the detection of gravitational waves will first operate in a test configuration, known as the Central Area Interferometer (CITF). The subject of this thesis consists of a study for the global control of this interferometer. In particular, the problems of auto-alignment and acquisition of lock are addressed. First, an investigation of the CITF optical response to longitudinal and angular mirror movements is given. On the basis of this study, we show how the ratio of photodiode signals can be used to detect and control the dark fringe when the CITF is far from its operating point (locked state). Furthermore, we present the simulation results of a quadrant photodiode configuration capable of reconstructing the mirrors' tilts once the CITF is in a locked state. The performance of a control system for the auto-alignment is then given. A study on the mode-cleaner prototype MC30 is then introduced in order to comprehend the process of lock acquisition by a linear feedback system for two different finesse values: F ≅100 and F ≅ 1600. We define a threshold velocity for the mirrors' relative motion below which acquisition of lock is possible. A phenomenon, referred to as ringing effect, was observed and examined on the MC30 prototype in high finesse. The results of numerical calculations allowed us to fit measurement and estimate from them the cavity finesse as well as the mirrors' relative velocity during the resonance crossing. An empirical formula is then presented capable of determine the relative velocity from the positions of the oscillations' minima and maxima. An algorithm to guide into lock the CITF is then presented, consisting of an iterative procedure of velocity reconstruction and pulse application. A numerical calculation simulated the algorithm, the mirrors' motion, the optical response and the ADCs' process. As a result, acquisition times of the order of one second were observed: an improvement of more than one order of magnitude was

  3. Computer-to-process interface in JET's control and diagnostic systems

    International Nuclear Information System (INIS)

    Fullard, K.; Dorling, S.E.; Montfoort, J.E. van

    1986-01-01

    The JET Control and Data Acquisition System, CODAS, uses some 40,000 electrical signals to control and monitor JET's various systems. This paper describes the electronic equipment and the data transmission techniques which are used to route these signals to and from the centrally-located computers is described. Special emphasis has been placed on the practical aspects of building and maintaining such a large system of approaching 8,000 modules. Quantities and costs of the various classes of modules and cables are given together with an outline of the quality assurance and organisational techniques adopted. (author)

  4. Role Based Access Control system in the ATLAS experiment

    CERN Document Server

    Valsan, M L; The ATLAS collaboration; Lehmann Miotto, G; Scannicchio, D A; Schlenker, S; Filimonov, V; Khomoutnikov, V; Dumitru, I; Zaytsev, A S; Korol, A A; Bogdantchikov, A; Caramarcu, C; Ballestrero, S; Darlea, G L; Twomey, M; Bujor, F; Avolio, G

    2011-01-01

    The complexity of the ATLAS experiment motivated the deployment of an integrated Access Control System in order to guarantee safe and optimal access for a large number of users to the various software and hardware resources. Such an integrated system was foreseen since the design of the infrastructure and is now central to the operations model. In order to cope with the ever growing needs of restricting access to all resources used within the experiment, the Roles Based Access Control (RBAC) previously developed has been extended and improved. The paper starts with a short presentation of the RBAC design, implementation and the changes made to the system to allow the management and usage of roles to control access to the vast and diverse set of resources. The paper continues with a detailed description of the integration across all areas of the system: local Linux and Windows nodes in the ATLAS Control Network (ATCN), the Linux application gateways offering remote access inside ATCN, the Windows Terminal Serv...

  5. Role Based Access Control System in the ATLAS Experiment

    CERN Document Server

    Valsan, M L; The ATLAS collaboration; Lehmann Miotto, G; Scannicchio, D A; Schlenker, S; Filimonov, V; Khomoutnikov, V; Dumitru, I; Zaytsev, A S; Korol, A A; Bogdantchikov, A; Avolio, G; Caramarcu, C; Ballestrero, S; Darlea, G L; Twomey, M; Bujor, F

    2010-01-01

    The complexity of the ATLAS experiment motivated the deployment of an integrated Access Control System in order to guarantee safe and optimal access for a large number of users to the various software and hardware resources. Such an integrated system was foreseen since the design of the infrastructure and is now central to the operations model. In order to cope with the ever growing needs of restricting access to all resources used within the experiment, the Roles Based Access Control (RBAC) previously developed has been extended and improved. The paper starts with a short presentation of the RBAC design, implementation and the changes made to the system to allow the management and usage of roles to control access to the vast and diverse set of resources. The paper continues with a detailed description of the integration across all areas of the system: local Linux and Windows nodes in the ATLAS Control Network (ATCN), the Linux application gateways offering remote access inside ATCN, the Windows Terminal Serv...

  6. Analysis of man-machine interaction for control and display system in main control room of light water reactor

    International Nuclear Information System (INIS)

    Santosa, Kussigit; Supriatna, Piping; Karlina, Itjeu; Widagdo, Suharyo; Darlis; Sudiono, Bambang

    1998-01-01

    One of potential hazard in Nuclear Power Plant is the failure of its operation. The accident or operation failure in the reactor must be concerned event its probability is low. The important thing should be concerned is 'Analysis of Man-Machine Interaction (MMI) for Control and Display System in Main Control Room (MCR) of Nuclear Power Reactor', especially LWR type. Control and Display System in MCR of Reactor is the main part of MMI link process in Reactor MCR work system. Signal from display system showed performance process in reactor, while this signal will be received by operator. This signal will be described through central nerve for making decision what kind must be done. Then the operator manage the next process of reactor operation through control system. So by knowing Analysis of Man-Machine Interaction for Control and Display System in Main Control Room of Power Reactor, we can understand human error probability of the operator in reactor operation

  7. Towards Realization of Intelligent Medical Treatment at Nanoscale by Artificial Microscopic Swarm Control Systems

    Directory of Open Access Journals (Sweden)

    Alireza Rowhanimanesh

    2017-07-01

    Full Text Available Background: In this paper, the novel concept of artificial microscopic swarm control systems is proposed as a promising approach towards realization of intelligent medical treatment at nanoscale. In this new paradigm, treatment is done autonomously at nanoscale within the patient’s body by the proposed swarm control systems.Methods: From control engineering perspective, medical treatment can be considered as a control problem, in which the ultimate goal is to find the best feasible way to change the state of diseased tissue from unhealthy to healthy in presence of uncertainty. Although a living tissue is a huge swarm of microscopic cells, nearly all of the common treatment methods are based on macroscopic centralized control paradigm. Inspired by natural microscopic swarm control systems such as nervous, endocrine and immune systems that work based on swarm control paradigm, medical treatment needs a paradigm shift from macroscopic centralized control to microscopic swarm control. An artificial microscopic swarm control system consists of a huge number of very simple autonomous microscopic agents that exploit swarm intelligence to realize sense, control (computing and actuation at nanoscale in local, distributed and decentralized manner. This control system can be designed based on mathematical analysis and computer simulation.Results: The proposed approach is used for treatment of atherosclerosis and cancer based on mathematical analysis and in-silico study.Conclusion: The notion of artificial microscopic swarm control systems opens new doors towards realization of autonomous and intelligent medical treatment at nanoscale within the patient’s body.

  8. Development of a completely decentralized control system for modular continuous conveyors

    OpenAIRE

    Mayer, Stephan H.

    2009-01-01

    To increase the flexibility of application of continuous conveyor systems, a completely decentralized control system for a modular conveyor system is introduced in the paper. This system is able to carry conveyor units without any centralized infrastructure. Based on existing methods of decentralized data transfer in IT networks, single modules operate autonomously and, after being positioned into the required topology, independently connect together to become a functioning conveyor system.

  9. Rapid Prototyping of the Central Safety System for Nuclear Risk in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Scibile, L. [ITER Organization, 13 - St. Paul lez Durance (France); Ambrosino, G.; De Tommasi, G.; Pironti, A. [Euratom-ENEA-CREATE, Universita di Napoli Federico II, Napoli (Italy)

    2009-07-01

    Full text of publication follows: In the current ITER Baseline design, the Central Safety System for Nuclear Risk (CSS-N) is the safety control system in charge to assure nuclear safety for the plant, personnel and environment. In particular it is envisaged that the CSS shall interface to the plant safety systems for nuclear risk and shall coordinate the individual protection provided by the intervention of these systems by the activation, where required, of additional protections. The design of such a system, together with its implementation, strongly depends on the requirements, particularly in terms of reliability. The CSS-N is a safety critical system, thus its validation and commissioning play a very important role, since the required level of reliability must be demonstrated. In such a scenario, where a new and non-conventional system has to be deployed, it is strongly recommended to use modeling and simulation tools since the early design phase. Indeed, the modeling tools will help in the definition of the system requirements, and they will be used to test and validate the control logic. Furthermore these tools can be used to rapid design the safety system and to carry out hardware-in-the-loop (HIL) simulations, which permit to assess the performance of the control hardware against a plant simulator. Both a control system prototype and a safety system oriented plant simulator have been developed to assess first the requirements and then the performance of the CSS-N. In particular the presented SW/HW framework permits to design and verify the CSS protection logics and to test and validate these logics by means of HIL simulations. This work introduces both the prototype and plant simulator architectures, together with the methodology adopted to design and implement these validation tools. (authors)

  10. High speed serial communications for control systems

    International Nuclear Information System (INIS)

    Mathieson, D.; Kalbfleisch, C.; Hunt, S.; Low, K.

    1993-01-01

    The Superconducting Super Collider Laboratory is a complex of accelerators being built in Ellis County, Texas. The SSCL control system consists of front-end processors and their associated control points remotely distributed from the Central and Regional control rooms. Control messages passing between these locations require timely (deterministic) distribution. A prototype network consisting of point-to-point links utilizing commercial T1 (1.544 Mb/s) communication boards has been implemented. These dedicated communication links will replace networking services traditionally provided for by shared medium networks like Ethernet(IEEE 802.3) and FDDI(IEEE 802.5). A seamless migration will be achieved by using packet encapsulation based on PPP(Point-to-Point Protocol, RFC 1171). All other networking functions including routing and reliable delivery are still being handled by the usual internet services. A distributed control system that currently uses Ethernet for communication is being re-implemented using these point-to-point links. The authors report on throughput measurements, timing constraints and ease of transition of a point-to-point network

  11. Uniformity testing: assessment of a centralized web-based uniformity analysis system.

    Science.gov (United States)

    Klempa, Meaghan C

    2011-06-01

    Uniformity testing is performed daily to ensure adequate camera performance before clinical use. The aim of this study is to assess the reliability of Beth Israel Deaconess Medical Center's locally built, centralized, Web-based uniformity analysis system by examining the differences between manufacturer and Web-based National Electrical Manufacturers Association integral uniformity calculations measured in the useful field of view (FOV) and the central FOV. Manufacturer and Web-based integral uniformity calculations measured in the useful FOV and the central FOV were recorded over a 30-d period for 4 cameras from 3 different manufacturers. These data were then statistically analyzed. The differences between the uniformity calculations were computed, in addition to the means and the SDs of these differences for each head of each camera. There was a correlation between the manufacturer and Web-based integral uniformity calculations in the useful FOV and the central FOV over the 30-d period. The average differences between the manufacturer and Web-based useful FOV calculations ranged from -0.30 to 0.099, with SD ranging from 0.092 to 0.32. For the central FOV calculations, the average differences ranged from -0.163 to 0.055, with SD ranging from 0.074 to 0.24. Most of the uniformity calculations computed by this centralized Web-based uniformity analysis system are comparable to the manufacturers' calculations, suggesting that this system is reasonably reliable and effective. This finding is important because centralized Web-based uniformity analysis systems are advantageous in that they test camera performance in the same manner regardless of the manufacturer.

  12. Chaos control of ferroresonance system based on RBF-maximum entropy clustering algorithm

    International Nuclear Information System (INIS)

    Liu Fan; Sun Caixin; Sima Wenxia; Liao Ruijin; Guo Fei

    2006-01-01

    With regards to the ferroresonance overvoltage of neutral grounded power system, a maximum-entropy learning algorithm based on radial basis function neural networks is used to control the chaotic system. The algorithm optimizes the object function to derive learning rule of central vectors, and uses the clustering function of network hidden layers. It improves the regression and learning ability of neural networks. The numerical experiment of ferroresonance system testifies the effectiveness and feasibility of using the algorithm to control chaos in neutral grounded system

  13. Big brother - a fully automated control system for the DELPHI experiment

    International Nuclear Information System (INIS)

    Franek, B.; Sekulin, R.; Doenszelmann, M.; Gasper, C.; Charpentier, Jonker, M.

    1994-01-01

    The integrated control system of the DELPHI experiment is described. It allows the data to be taken in an almost automatic fashion. This is achieved by computer monitoring of the states of the LEP machine, the DELPHI subdetectors (SC) and the Data Acquisition System (DAS). Depending on these states, computer initiated actions are then taken. It has been designed using open-quote State Manager close-quote concept already used for local and central controls of DAS and SC

  14. Magnetic resonance imaging of central nervous system haemorrhage

    International Nuclear Information System (INIS)

    Silberstein, M.; Hennessy, O.

    1993-01-01

    The variable magnetic resonance imaging appearances of central nervous system haemorrhage, both intra- and extra-axial, are described. These will vary with the type of image contrast (T1 or T2 weighting), the nature of the imaging sequence (spin-echo or gradient-echo) and the time from onset of haemorrhage. Magnetic resonance imaging is a useful technique for imaging haemorrhage in the central nervous system as it yields temporal information about haematoma development, and it is the only non-invasive means of imaging intraspinal haemorrhage. However, in the imaging of haematomas within 24 h of onset and in subarachnoid haemorrhage computed tomography is the investigation of choice. 13 refs., 6 figs

  15. Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia.

    Science.gov (United States)

    Strati, Paolo; Uhm, Joon H; Kaufmann, Timothy J; Nabhan, Chadi; Parikh, Sameer A; Hanson, Curtis A; Chaffee, Kari G; Call, Timothy G; Shanafelt, Tait D

    2016-04-01

    Abroad array of conditions can lead to neurological symptoms in chronic lymphocytic leukemia patients and distinguishing between clinically significant involvement of the central nervous system by chronic lymphocytic leukemia and symptoms due to other etiologies can be challenging. Between January 1999 and November 2014, 172 (4%) of the 4174 patients with chronic lymphocytic leukemia followed at our center had a magnetic resonance imaging of the central nervous system and/or a lumbar puncture to evaluate neurological symptoms. After comprehensive evaluation, the etiology of neurological symptoms was: central nervous system chronic lymphocytic leukemia in 18 patients (10% evaluated by imaging and/or lumbar puncture, 0.4% overall cohort); central nervous system Richter Syndrome in 15 (9% evaluated, 0.3% overall); infection in 40 (23% evaluated, 1% overall); autoimmune/inflammatory conditions in 28 (16% evaluated, 0.7% overall); other cancer in 8 (5% evaluated, 0.2% overall); and another etiology in 63 (37% evaluated, 1.5% overall). Although the sensitivity of cerebrospinal fluid analysis to detect central nervous system disease was 89%, the specificity was only 42% due to the frequent presence of leukemic cells in the cerebrospinal fluid in other conditions. No parameter on cerebrospinal fluid analysis (e.g. total nucleated cells, total lymphocyte count, chronic lymphocytic leukemia cell percentage) were able to offer a reliable discrimination between patients whose neurological symptoms were due to clinically significant central nervous system involvement by chronic lymphocytic leukemia and another etiology. Median overall survival among patients with clinically significant central nervous system chronic lymphocytic leukemia and Richter syndrome was 12 and 11 months, respectively. In conclusion, clinically significant central nervous system involvement by chronic lymphocytic leukemia is a rare condition, and neurological symptoms in patients with chronic lymphocytic

  16. System Controls on the South Texas Sand Sheet

    Science.gov (United States)

    Barrineau, Clifton Patrick

    Semi-stabilized dune systems are important indicators of Quaternary drought variability across central North America. The South Texas sand sheet (STSS) is the southernmost relict dune system in central North America and is exposed to higher evapotranspiration and moisture variability than similar landscapes farther north. This study uses multi-scale analysis of LiDAR data, geophysical surveys, optically stimulated luminescence dates of core samples, and X-ray fluorescence analysis to identify historical periods of desertification across the STSS. These data suggest long-term relationships between climate, ecological disturbances, geological framework, and desertification. Aeolian activations dated at ca. 75, 230, 2000, 4100, and 6600 yr bp correspond to periods of persistent regional drought, changes in sediment supply, and anthropogenic disturbances of native ecology. From these results it appears that regionalized activation in semi-stabilized dune systems is controlled primarily by climatic variations that reduce the overall moisture available for maintaining vigorous vegetation growth, while localized activation patterns depend more on stresses related to site-specific morphodynamics as well as human activity. With enhanced aridity forecast for much of central North America through the 21 st century, understanding the specific thresholds of desertification is an important step towards building a conceptual model of desertification in semi-stabilized dune landscapes.

  17. Solar central receiver reformer system for ammonia plants

    Science.gov (United States)

    1980-07-01

    Details of the conceptual design, economic analysis, and development plan for a solar central receiver system for retrofitting the Valley Nitrogen Producers, Inc., El Centro, California 600 ST/SD Ammonia Plant are presented. The retrofit system consists of a solar central receiver reformer (SCRR) operating in parallel with the existing fossil fired reformer. Steam and hydrocarbon react in the catalyst filled tubes of the inner cavity receiver to form a hydrogen rich mixture which is the syngas feed for the ammonia production. The SCRR system displaces natural gas presently used in the fossil reformer combustion chamber. The solar reformer retrofit system characteristics and its interface with the existing plant are simple, incorporating state of the art components with proven technology. A northfield composed of one thousand forty second generation heliostats provides solar energy to the receiver which is positioned on top of a 90 meter high steel tower. The overall economics of this system can provide over 20% discount cash flow rate of return with proper investment and market conditions.

  18. Modular Online Uninterruptible Power System Plug’n’Play Control and Stability Analysis

    DEFF Research Database (Denmark)

    Zhang, Chi; Coelho, Ernane A. A.; Guerrero, Josep M.

    2016-01-01

    In this paper, a plug`n'play control strategy proposed for modular online UPS system is presented, which allows to plug the UPS modules in or out randomly. This provides a less difficulty for the maintenance of the whole system. A two-level control scheme was proposed, including local controllers...... to achieve active and reactive power sharing and central controllers to maintain synchronization capability, which allows the online UPS modular system having faster dynamic performance according to the Standard IEC 62040-3. A detailed small signal mathematical model was developed in order to analyze...... the proposed modular online UPS system. Experimental results and data are presented to validate the stability analysis and support the proposed plug`n'play control feasibility....

  19. Bone mineral density in subjects using central nervous system-active medications.

    Science.gov (United States)

    Kinjo, Mitsuyo; Setoguchi, Soko; Schneeweiss, Sebastian; Solomon, Daniel H

    2005-12-01

    Decreased bone mineral density defines osteoporosis according to the World Health Organization and is an important predictor of future fractures. The use of several types of central nervous system-active drugs, including benzodiazepines, anticonvulsants, antidepressants, and opioids, have all been associated with increased risk of fracture. However, it is unclear whether such an increase in risk is related to an effect of bone mineral density or to other factors, such as increased risk of falls. We sought to examine the relationship between bone mineral density and the use of benzodiazepines, anticonvulsants, antidepressants, and opioids in a representative US population-based sample. We analyzed data on adults aged 17 years and older from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). Total femoral bone mineral density of 7114 male and 7532 female participants was measured by dual-energy x-ray absorptiometry. Multivariable linear regression models were used to quantify the relation between central nervous system medication exposure and total femoral bone mineral density. Models controlled for relevant covariates, including age, sex, and body mass index. In linear regression models, significantly reduced bone mineral density was found in subjects taking anticonvulsants (0.92 g/cm2; 95% confidence interval [CI]: 0.89 to 0.94) and opioids (0.92 g/cm2; 95% CI: 0.88 to 0.95) compared with nonusers (0.95 g/cm2; 95% CI: 0.95 to 0.95) after adjusting for several potential confounders. The other central nervous system-active drugs--benzodiazepines or antidepressants--were not associated with significantly reduced bone mineral density. In cross-sectional analysis of NHANES III, anticonvulsants and opioids (but not benzodiazepines or antidepressants) were associated with significantly reduced bone mineral density. These findings have implications for fracture-prevention strategies.

  20. Hypersensitivity Responses in the Central Nervous System

    DEFF Research Database (Denmark)

    Khorooshi, Reza; Asgari, Nasrin; Mørch, Marlene Thorsen

    2015-01-01

    of pathology in neuromyelitis optica (NMO), a central nervous system (CNS) demyelinating disease where activated neutrophils infiltrate, unlike in MS. The most widely used model for MS, experimental autoimmune encephalomyelitis, is an autoantigen-immunized disease that can be transferred to naive animals...

  1. A VME based cryogenic data acquisition and control system (CRYO-DACS)

    International Nuclear Information System (INIS)

    Antony, Joby; Rajkumar; Datta, T.S.

    2005-01-01

    This report describes a newly developed VME based data acquisition and control system named CRYO-DACS for acquiring and controlling various analog and digital cryogenic parameters from equipment's like beam-line cryostats, Helium compressors, liquefier, cryogenic distribution line etc. A new central control room has been set-up for the remote controls and monitoring. The system monitors various analog parameters like temperature, pressure, vacuum and cryogenic fluid levels inside the cryostats and performs closed loop controls of cryogen valves. The hardware architecture of CRYO-DACS is multi-crate distributed VME, all linked by workstation clients in 100 Mb/s LAN for distributed logging, historical trending, analysis, alarm management and control GUIs. (author)

  2. An accountancy system for nuclear materials control in research centres

    International Nuclear Information System (INIS)

    Buttler, R.; Bueker, H.; Vallee, J.

    1979-01-01

    The Nuclear Accountancy and Control System (NACS) was developed at KFA Juelich in accordance with the requirements of the Non-Proliferation Treaty. The main features are (1) recording of nuclear material in inventory items. These are combined to form batches wherever suitable; (2) extrapolation of accounting data as a replacement for detailed measurement of inventory items data. Recording and control of nuclear material are carried out on two levels with access to a common data bank. The lower level deals with nuclear materials handling plus internal management while on the upper level there is a central control point which is responsible for nuclear safeguarding within the entire research centre. By keeping the organizational and technical infrastructure it was possible to develop a system which is both economical and operator-oriented. In this system the emphasis of nuclear safeguarding is placed on the acquisition of the nuclear material inventory. As much consideration has been given to the interests of the various operational levels and organizational units as to internal and national regulations. Since it is part of the safeguarding and control system, access to the NACS must be restricted to a limited number of users only. Furthermore, it must include facilities for manual control in the form of records. Authorization for access must correspond with the various tasks of different user groups. All necessary data are acquired decentrally in the organizational units and entered via a terminal. It is available to the user groups on both levels through a central data bank. To meet all requirements, the NACS has been designed as an integrated, computer-assisted information system for the automated processing of extensive and multi-level nuclear materials data. As part of the preventive measures entailed with nuclear safeguarding, the accountancy system enables the operator of a nuclear plant to furnish proof of non-diversion of nuclear material. (author)

  3. 75 FR 75681 - Peripheral and Central Nervous System Drugs Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-12-06

    ...] Peripheral and Central Nervous System Drugs Advisory Committee; Notice of Meeting AGENCY: Food and Drug...: Peripheral and Central Nervous System Drugs Advisory Committee. General Function of the Committee: To provide...) and/or abnormal vascularity (abnormal blood supply and circulation) of the central nervous system. The...

  4. An integrated architecture for the ITER RH control system

    International Nuclear Information System (INIS)

    Hamilton, David Thomas; Tesini, Alessandro

    2012-01-01

    . It is distinguished from other Plant systems by the man-in-the-loop nature of RH operations and the need for control rooms at a level below the main control room. The RH control system architecture has been designed to also support the central monitoring and coordination of the RH activities.

  5. Effect of central ventilation and air conditioner system on the concentration and health risk from airborne polycyclic aromatic hydrocarbons.

    Science.gov (United States)

    Lv, Jinze; Zhu, Lizhong

    2013-03-01

    Central ventilation and air conditioner systems are widely utilized nowadays in public places for air exchange and temperature control, which significantly influences the transfer of pollutants between indoors and outdoors. To study the effect of central ventilation and air conditioner systems on the concentration and health risk from airborne pollutants, a spatial and temporal survey was carried out using polycyclic aromatic hydrocarbons (PAHs) as agent pollutants. During the period when the central ventilation system operated without air conditioning (AC-off period), concentrations of 2-4 ring PAHs in the model supermarket were dominated by outdoor levels, due to the good linearity between indoor air and outdoor air (r(p) > 0.769, p air conditioner systems were working simultaneously (AC-on period), although the total levels of PAHs were increased, the concentrations and percentage of the particulate PAHs indoors declined significantly. The BaP equivalency (BaPeq) concentration indicated that utilization of air conditioning reduced the health risks from PAHs in the model supermarket.

  6. Framework and Method for Controlling a Robotic System Using a Distributed Computer Network

    Science.gov (United States)

    Sanders, Adam M. (Inventor); Barajas, Leandro G. (Inventor); Permenter, Frank Noble (Inventor); Strawser, Philip A. (Inventor)

    2015-01-01

    A robotic system for performing an autonomous task includes a humanoid robot having a plurality of compliant robotic joints, actuators, and other integrated system devices that are controllable in response to control data from various control points, and having sensors for measuring feedback data at the control points. The system includes a multi-level distributed control framework (DCF) for controlling the integrated system components over multiple high-speed communication networks. The DCF has a plurality of first controllers each embedded in a respective one of the integrated system components, e.g., the robotic joints, a second controller coordinating the components via the first controllers, and a third controller for transmitting a signal commanding performance of the autonomous task to the second controller. The DCF virtually centralizes all of the control data and the feedback data in a single location to facilitate control of the robot across the multiple communication networks.

  7. Miniaturized Airborne Imaging Central Server System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance-computer-based electronic backend that...

  8. Miniaturized Airborne Imaging Central Server System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a miniaturized airborne imaging central server system (MAICSS). MAICSS is designed as a high-performance computer-based electronic backend that...

  9. Experimentation of RT-LOTOS for a critical function of a power plant instrumentation and control system; Experimentation de RT-LOTOS pour une fonction critique d`un systeme de controle-commande en centrale

    Energy Technology Data Exchange (ETDEWEB)

    Andriantsiiferana, L.; Courtiat, J.P.; De Oliveira, R.C.

    1996-01-01

    This document is the final report of the contract between LAAS-CNRS and the EdF Direction of Researches and Studies about the experimentation of RT-LOTOS formal description technique on a critical function of a nuclear power plant instrumentation and control system. This report comprises 4 parts: part 1 describes the RT-LOTOS (Real Time-Language of Temporal Ordering Specifications) tutorial and its RTL tool environment, the different RT-LOTOS operators and semantics, and the RTL tool main functionalities; part 2 deals with the methodology and the global architecture for the specification and validation of the CCT (Central Calculator for Treatment); part 3 gives more details about the different processes identified in the specification architecture and presents the main results obtained for the validation of the nominal functioning; part 4 describes some exceptional situations and shows how some failures and their associated recovery mechanisms can be modelled. (J.S.). 6 refs., 53 figs., 5 tabs., 2 appends.

  10. Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial

    NARCIS (Netherlands)

    Vranken, J. H.; Hollmann, M. W.; van der Vegt, M. H.; Kruis, M. R.; Heesen, M.; Vos, K.; Pijl, A. J.; Dijkgraaf, M. G. W.

    2011-01-01

    The mechanisms underlying central neuropathic pain are poorly understood. Pain inhibitory mechanisms including sertononergic and norepinephrine systems may be dysfunctional. In this randomized, double-blinded, placebo-controlled trial we evaluated the effects of duloxetine on pain relief

  11. Non-viral Nucleic Acid Delivery Strategies to the Central Nervous System

    Directory of Open Access Journals (Sweden)

    James-Kevin Tan

    2016-11-01

    Full Text Available With an increased prevalence and understanding of central nervous system injuries and neurological disorders, nucleic acid therapies are gaining promise as a way to regenerate lost neurons or halt disease progression. While more viral vectors have been used clinically as tools for gene delivery, non-viral vectors are gaining interest due to lower safety concerns and the ability to deliver all types of nucleic acids. Nevertheless, there are still a number of barriers to nucleic acid delivery. In this focused review, we explore the in vivo challenges hindering non-viral nucleic acid delivery to the central nervous system and the strategies and vehicles used to overcome them. Advantages and disadvantages of different routes of administration including: systemic injection, cerebrospinal fluid injection, intraparenchymal injection, and peripheral administration are discussed. Non-viral vehicles and treatment strategies that have overcome delivery barriers and demonstrated in vivo gene transfer to the central nervous system are presented. These approaches can be used as guidelines in developing synthetic gene delivery vectors for central nervous system applications and will ultimately bring non-viral vectors closer to clinical application.

  12. Imaging of the fetal central nervous system

    NARCIS (Netherlands)

    Pistorius, L.R.

    2008-01-01

    Introduction : Ultrasound and MR imaging of the fetal central nervous system (CNS) develop at an ever-increasing rate. Theoretically, the two modalities should be synergistic, but a literature review revealed the difficulties of determining the merit of either technique and revealed gaps in our

  13. Executive control systems in the engineering design environment

    Science.gov (United States)

    Hurst, P. W.; Pratt, T. W.

    1985-01-01

    Executive Control Systems (ECSs) are software structures for the unification of various engineering design application programs into comprehensive systems with a central user interface (uniform access) method and a data management facility. Attention is presently given to the most significant determinations of a research program conducted for 24 ECSs, used in government and industry engineering design environments to integrate CAD/CAE applications programs. Characterizations are given for the systems' major architectural components and the alternative design approaches considered in their development. Attention is given to ECS development prospects in the areas of interdisciplinary usage, standardization, knowledge utilization, and computer science technology transfer.

  14. Acute Central Nervous System Complications in Pediatric Acute Lymphoblastic Leukemia.

    Science.gov (United States)

    Baytan, Birol; Evim, Melike Sezgin; Güler, Salih; Güneş, Adalet Meral; Okan, Mehmet

    2015-10-01

    The outcome of childhood acute lymphoblastic leukemia has improved because of intensive chemotherapy and supportive care. The frequency of adverse events has also increased, but the data related to acute central nervous system complications during acute lymphoblastic leukemia treatment are sparse. The purpose of this study is to evaluate these complications and to determine their long term outcome. We retrospectively analyzed the hospital reports of 323 children with de novo acute lymphoblastic leukemia from a 13-year period for acute neurological complications. The central nervous system complications of leukemic involvement, peripheral neuropathy, and post-treatment late-onset encephalopathy, and neurocognitive defects were excluded. Twenty-three of 323 children (7.1%) suffered from central nervous system complications during acute lymphoblastic leukemia treatment. The majority of these complications (n = 13/23; 56.5%) developed during the induction period. The complications included posterior reversible encephalopathy (n = 6), fungal abscess (n = 5), cerebrovascular lesions (n = 5), syndrome of inappropriate secretion of antidiuretic hormone (n = 4), and methotrexate encephalopathy (n = 3). Three of these 23 children (13%) died of central nervous system complications, one from an intracranial fungal abscess and the others from intracranial thrombosis. Seven of the survivors (n = 7/20; 35%) became epileptic and three of them had also developed mental and motor retardation. Acute central neurological complications are varied and require an urgent approach for proper diagnosis and treatment. Collaboration among the hematologist, radiologist, neurologist, microbiologist, and neurosurgeon is essential to prevent fatal outcome and serious morbidity. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Run Control Communication for the Upgrade of the ATLAS Muon-to-Central-Trigger-Processor Interface (MUCTPI)

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00223859; The ATLAS collaboration; Armbruster, Aaron James; Carrillo-Montoya, German D.; Chelstowska, Magda Anna; Czodrowski, Patrick; Deviveiros, Pier-Olivier; Eifert, Till; Ellis, Nicolas; Galster, Gorm Aske Gram Krohn; Haas, Stefan; Helary, Louis; Lagkas Nikolos, Orestis; Marzin, Antoine; Pauly, Thilo; Ryjov, Vladimir; Schmieden, Kristof; Silva Oliveira, Marcos Vinicius; Stelzer, Harald Joerg; Vichoudis, Paschalis; Wengler, Thorsten; Farthouat, Philippe

    2018-01-01

    The Muon-to-Central Trigger Processor Interface (MUCTPI) of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN will be upgraded to an ATCA blade system for Run 3. The new design requires development of new communication models for control, configuration and monitoring. A System-on-Chip (SoC) with a programmable logic part and a processor part will be used for communication to the run control system and to the MUCTPI processing FPGAs. Different approaches have been compared. First, we tried an available UDP-based implementation in firmware for the programmable logic. Although this approach works as expected, it does not provide any flexibility to extend the functionality to more complex operations, e.g. for serial protocols. Second, we used the SoC processor with an embedded Linux operating system and an application-specific software written in C++ using a TCP remote-procedure-call approach. The software is built and maintained using the Yocto/OpenEmbedded framework. This approach was successfully...

  16. Run control communication for the upgrade of the ATLAS Muon-to-Central Trigger Processor Interface (MUCTPI)

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00223859; The ATLAS collaboration; Armbruster, Aaron James; Carrillo-Montoya, German D.; Chelstowska, Magda Anna; Czodrowski, Patrick; Deviveiros, Pier-Olivier; Eifert, Till; Ellis, Nicolas; Farthouat, Philippe; Galster, Gorm Aske Gram Krohn; Haas, Stefan; Helary, Louis; Lagkas Nikolos, Orestis; Marzin, Antoine; Pauly, Thilo; Ryjov, Vladimir; Schmieden, Kristof; Silva Oliveira, Marcos Vinicius; Stelzer, Harald Joerg; Vichoudis, Paschalis; Wengler, Thorsten

    The Muon-to-Central-Trigger-Processor Interface (MUCTPI) of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN will be upgraded to an ATCA blade system for Run 3, starting in 2021. The new design requires development of new communication models for control, configuration and monitoring. A System-on-Chip (SoC) with a programmable logic part and a processor part will be used for communication to the run control system and to the MUCTPI processing FPGAs. Different approaches have been compared. First, we tried an available UDP-based implementation in firmware for the programmable logic. Although this approach works as expected, it does not provide any flexibility to extend the functionality to more complex operations, e.g. for serial protocols. Second, we used a SoC processor with an embedded Linux operating system and an application-specific software written in C++ using a TCP remote-procedure-call approach. The software is built and maintained using the framework of the Yocto Project. This approa...

  17. Primary central nervous system B-cell lymphoma in a young dog

    Science.gov (United States)

    Kim, Na-Hyun; Ciesielski, Thomas; Kim, Jung H.; Yhee, Ji-Young; Im, Keum-Soon; Nam, Hae-Mi; Kim, Il-Hwan; Kim, Jong-Hyuk; Sur, Jung-Hyang

    2012-01-01

    This report describes a primary central nervous system B-cell lymphoma in a 3-year-old intact female Maltese dog. Canine primary central nervous system lymphomas constitute about 4% of all intracranial primary neoplasms, but comprehensive histopathologic classifications have rarely been carried out. This is the first report of this disease in a young adult dog. PMID:23115372

  18. Key developments of a rod control system - 15101

    International Nuclear Information System (INIS)

    Pouillot, M.; Jegou, H.; Duthou, A.

    2015-01-01

    The aim of the Rod Control System is to carry out the insertion and withdrawal of control rod clusters to provide the power required by the grid (G-mode control), to control the temperature of the reactor, or to provide negative reactivity margin when the reactor is shut down. The rod control system is not classified important for safety, but its correct operation is essential for the availability of the reactor, as the spurious drop of a single cluster usually results in a reactor trip. Rolls-Royce has been designing, manufacturing and providing rod control systems since 1977, in France, China, Belgium, Korea, and South Africa, as an original manufacturer and for modernization projects. All the corresponding nuclear units share the following features, key points for the system design: -) The power source is a three-phased 260 Vac with neutral, provided by zigzag-coupled alternators; -) The Control Rod Drive Mechanisms (CRDM) are 'three-coil type': Stationary Gripper (SG), Movable Gripper (MG) and Lift Coil (LC); -) Rod clusters are arranged in banks and sub-banks, the bank being composed of one or two sub-banks and a sub-bank is a set of 4 clusters moved simultaneously, the central cluster being an exception; and -) Most of those reactors are operated in G-mode (load following). (authors)

  19. Computer network data communication controller for the Plutonium Protection System (PPS)

    International Nuclear Information System (INIS)

    Rogers, M.S.

    1978-10-01

    Systems which employ several computers for distributed processing must provide communication links between the computers to effectively utilize their capacity. The technique of using a central network controller to supervise and route messages on a multicomputer digital communications net has certain economic and performance advantages over alternative implementations. Conceptually, the number of stations (computers) which can be accommodated by such a controller is unlimited, but practical considerations dictate a maximum of about 12 to 15. A Data Network Controller (DNC) has been designed around a M6800 microprocessor for use in the Plutonium Protection System (PPS) demonstration facilities

  20. Mathematics of an automatic control system for ventilation of gassy coal mines

    Energy Technology Data Exchange (ETDEWEB)

    Puchkov, L.A.; Bakhvalov, L.A.; Kravchenko, A.G.

    1987-09-01

    Describes and presents a circuit diagram of an automatic control system introduced to control ventilation in the Kommunist mine belonging to the Oktyabr'ugol' coal mining association. The system comprises: sensors to register the parameters of the mine atmosphere (e.g. methane and air flow rate); communications channels and remote control devices to convert and transmit the data; a CM-4 computer with a high-speed processor, an 128-256 kByte operating memory, external memory devices, polydiaphragm air flow controllers, devices for controlling the electric drive of the main ventilation system, devices for collecting, processing and displaying the data. This system uses two groups of algorithms: algorithms for a data subsystem responsible for centralized control of the mine atmosphere parameters and a control subsystem which forms and implements the necessary control commands. The main software is the DISMAIN program. Introducing this system increased the productivity of the mine by 2%, reduced energy consumption by 5-7% and increased safety levels. 2 refs

  1. Multiple myeloma and central nervous system involvement: experience of a Brazilian center.

    Science.gov (United States)

    Dias, Ana Luiza Miranda Silva; Higashi, Fabiana; Peres, Ana Lúcia M; Cury, Pricilla; Crusoé, Edvan de Queiroz; Hungria, Vânia Tietsche de Moraes

    The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse. This retrospective cohort study reviewed data from medical records of patients followed up at the Gammopathy Outpatient Clinic of Santa Casa de Misericórdia de São Paulo from January 2008 to December 2016. Twenty patients were included, with a median follow-up of 33.5 months after central nervous system infiltration. The prevalence was 7%. The median age at diagnosis of multiple myeloma was 56.1 years, with 70% of participants being female. Sixteen patients had central nervous system infiltration at diagnosis of multiple myeloma. Seventeen patients had exclusive osteodural lesions and three had infiltrations of the leptomeninge, of which one had exclusive involvement and two had associated osteodural lesions. The median overall survival was 40.3 months after central nervous system involvement. The median overall survival in the group with central nervous system infiltration at relapse was 7.4 months. The patients with leptomeningeal involvement had a median overall survival of 5.8 months. Central nervous system infiltration is a rare condition, but it should be considered as a possibility in patients with multiple myeloma and neurological symptoms. The best treatment regimen for this condition remains unknown and, in most cases, the prognosis is unfavorable. Copyright © 2017. Published by Elsevier Editora Ltda.

  2. Magnetic resonance imaging characteristics in four dogs with central nervous system neosporosis.

    Science.gov (United States)

    Parzefall, Birgit; Driver, Colin J; Benigni, Livia; Davies, Emma

    2014-01-01

    Neosporosis is a polysystemic disease that can affect dogs of any age and can cause inflammation of the central nervous system. Antemortem diagnosis can be challenging, as clinical and conventional laboratory test findings are often nonspecific. A previous report described cerebellar lesions in brain MRI studies of seven dogs and proposed that these may be characteristic for central nervous system Neosporosis. The purpose of this retrospective study was to describe MRI characteristics in another group of dogs with confirmed central nervous system neosporosis and compare them with the previous report. The hospital's database was searched for dogs with confirmed central nervous system neosporosis and four observers recorded findings from each dog's MRI studies. A total of four dogs met inclusion criteria. Neurologic examination was indicative of a forebrain and cerebellar lesion in dog 2 and multifocal central nervous system disease in dogs 1, 3, and 4. Magnetic resonance imaging showed mild bilateral and symmetrical cerebellar atrophy in three of four dogs (dogs 2, 3, 4), intramedullary spinal cord changes in two dogs (dogs 3, 4) and a mesencephalic and metencephalic lesion in one dog (dog 2). Multifocal brain lesions were recognized in two dogs (dogs 1, 4) and were present in the thalamus, lentiform nucleus, centrum semiovale, internal capsule, brainstem and cortical gray matter of the frontal, parietal or temporal lobe. Findings indicated that central nervous system neosporosis may be characterized by multifocal MRI lesions as well as cerebellar involvement in dogs. © 2014 American College of Veterinary Radiology.

  3. Central nervous system tuberculomata presenting as internuclear ...

    African Journals Online (AJOL)

    Central nervous system (CNS) tuberculoma can have variable presentation depending upon the site and number of tuberculomata. We are reporting a rare case of a 15 years old girl who presented to our hospital with binocular diplopia on right gaze. Clinical examination revealed left sided internuclear ophthalmoplegia ...

  4. Comparison of centralized and decentralized energy supply systems

    OpenAIRE

    Pfeifer, Thomas; Fahl, Ulrich; Voß, Alfred

    1991-01-01

    Communal energy programs are often embedded in a conception of a decentralized energy supply system where electricity is produced by a number of smaller power plants. For a comprehensive survey the question arises whether these decentralized systems are more advantageous than centralized systems with regard to the criterions energy consumption, safety of supply, environmental compatibility and economy. In the following, after a definition of the term "decentralized", the present structure of ...

  5. A Comparison of Clinical Outcomes with Regular- and Low-Profile Totally Implanted Central Venous Port Systems

    International Nuclear Information System (INIS)

    Teichgraeber, Ulf Karl-Martin; Steitparth, Florian; Cho, Chie Hee; Benter, Thomas; Gebauer, Bernhard

    2009-01-01

    The purpose of this study was to evaluate whether low-profile totally implanted central venous port systems can reduce the late complication of skin perforation. Forty patients (age, 57 ± 13 years; 22 females, 18 males) were randomized for the implantation of a low-profile port system, and another 40 patients (age, 61 ± 14 years; 24 females, 16 males) received a regular port system as control group. Indications for port catheter implantation were malignant disease requiring chemotherapy. All port implantations were performed in the angiography suite using sonographically guided central venous puncture and fluoroscopic guidance of the catheter placement. Procedure time, number of complications (procedure-related immediate, early, and late complications), and number of explantations were assessed. Follow-up was performed for 6 months. All port implantations were successfully completed in both study groups. There were two incidents of skin perforation observed in the control group. One skin perforation occurred 13 weeks and the other 16 weeks after port implantation (incidence, 5%) in patients with regular-profile port systems. Two infections were observed, one port infection in each study group. Both infections were characterized as catheter-related infections (infection rate: 0.15 catheter-related infections per 1000 catheter days). In conclusion, low-profile port systems can be placed as safely as traditional chest ports and reduce the risk of developing skin perforations, which occurs when the port system is too tight within the port pocket.

  6. Control of Flywheel Energy Storage Systems in Electrical Vehicle Charging Stations

    DEFF Research Database (Denmark)

    Sun, Bo

    energy storage system (FESS). The proposed PhD project supports a corresponding smart control strategy that could be termed “charging station to grid (CS2G)”. It explores the possibility of using a dedicated energy storage system (FESS) within the charging station to alleviate grid and market conditions...... converters is built and analyzed. |Based on modeling analysis, centralized and distributed control methods are both explored to realize the coordination control of each components in the system. Specially, this project proposes a “dc voltage vs speed” droop strategy for FESS control based on distributed bus...... function method when the system switches its operation behavior between two modes. Finally, a downscaled FCS prototype with FESS is built in the intelligent MG lab, and experiments and hardware-in-loop simulation results are conducted to verify the effectiveness and feasibility with the proposed FCS...

  7. H-infty Control of systems with multiple i/o delays

    NARCIS (Netherlands)

    Agoes Ariffin Moelja, A.A.; Meinsma, Gjerrit; Mirkin, Leonid

    2003-01-01

    In this paper the standard (four-block) H-infty control problem for systems with multiple i/o delays in the feedback loop is studied. The central idea is to see the multiple delay operator as a special series connection of elementary delay operators, called the adobe delay operators. The adobe delay

  8. Temperature control of evaporators in automotive waste heat recovery systems

    NARCIS (Netherlands)

    Oom, M.E.E.; Feru, E.; de Jager, A.G.; de Lange, H.C.; Ouwerkerk, H.

    2017-01-01

    his paper presents a control strategy for the steam generation process in automotive waste heat recovery systems that are based on the subcritical Rankine cycle. The central question is how to regulate the flow of water into the evaporator such that dry steam is generated at its outlet, subject to

  9. Central nervous system regulation of intestinal lipid and lipoprotein metabolism.

    Science.gov (United States)

    Farr, Sarah; Taher, Jennifer; Adeli, Khosrow

    2016-02-01

    In response to nutrient availability, the small intestine and brain closely communicate to modulate energy homeostasis and metabolism. The gut-brain axis involves complex nutrient sensing mechanisms and an integration of neuronal and hormonal signaling. This review summarizes recent evidence implicating the gut-brain axis in regulating lipoprotein metabolism, with potential implications for the dyslipidemia of insulin resistant states. The intestine and brain possess distinct mechanisms for sensing lipid availability, which triggers subsequent regulation of feeding, glucose homeostasis, and adipose tissue metabolism. More recently, central receptors, neuropeptides, and gut hormones that communicate with the brain have been shown to modulate hepatic and intestinal lipoprotein metabolism via parasympathetic and sympathetic signaling. Gut-derived glucagon-like peptides appear to be particularly important in modulating the intestinal secretion of chylomicron particles via a novel brain-gut axis. Dysregulation of these pathways may contribute to postprandial diabetic dyslipidemia. Emerging evidence implicates the central and enteric nervous systems in controlling many aspects of lipid and lipoprotein metabolism. Bidirectional communication between the gut and brain involving neuronal pathways and gut peptides is critical for regulating feeding and metabolism, and forms a neuroendocrine circuit to modulate dietary fat absorption and intestinal production of atherogenic chylomicron particles.

  10. Neurotropic Enterovirus Infections in the Central Nervous System.

    Science.gov (United States)

    Huang, Hsing-I; Shih, Shin-Ru

    2015-11-24

    Enteroviruses are a group of positive-sense single stranded viruses that belong to the Picornaviridae family. Most enteroviruses infect humans from the gastrointestinal tract and cause mild symptoms. However, several enteroviruses can invade the central nervous system (CNS) and result in various neurological symptoms that are correlated to mortality associated with enteroviral infections. In recent years, large outbreaks of enteroviruses occurred worldwide. Therefore, these neurotropic enteroviruses have been deemed as re-emerging pathogens. Although these viruses are becoming large threats to public health, our understanding of these viruses, especially for non-polio enteroviruses, is limited. In this article, we review recent advances in the trafficking of these pathogens from the peripheral to the central nervous system, compare their cell tropism, and discuss the effects of viral infections in their host neuronal cells.

  11. Neurotropic Enterovirus Infections in the Central Nervous System

    Directory of Open Access Journals (Sweden)

    Hsing-I Huang

    2015-11-01

    Full Text Available Enteroviruses are a group of positive-sense single stranded viruses that belong to the Picornaviridae family. Most enteroviruses infect humans from the gastrointestinal tract and cause mild symptoms. However, several enteroviruses can invade the central nervous system (CNS and result in various neurological symptoms that are correlated to mortality associated with enteroviral infections. In recent years, large outbreaks of enteroviruses occurred worldwide. Therefore, these neurotropic enteroviruses have been deemed as re-emerging pathogens. Although these viruses are becoming large threats to public health, our understanding of these viruses, especially for non-polio enteroviruses, is limited. In this article, we review recent advances in the trafficking of these pathogens from the peripheral to the central nervous system, compare their cell tropism, and discuss the effects of viral infections in their host neuronal cells.

  12. Intelligent system for lighting control in smart cities

    OpenAIRE

    de Paz Santana, Juan F.; Bajo Pérez, Javier; Rodríguez González, Sara; Villarrubia González, Gabriel; Corchado Rodríguez, Juan M.

    2017-01-01

    This paper presents an adaptive architecture that centralizes the control of public lighting and intelligent management to economize lighting and maintain maximum visual comfort in illuminated areas. To carry out this management, the architecture merges various techniques of artificial intelligence (AI) and statistics such as artificial neural networks (ANN), multi-agent systems (MAS), EM algorithm, methods based on ANOVA, and a Service Oriented Approach (SOA). It achieves optimization in ter...

  13. EUPOS - Satellite multifunctional system of reference stations in Central and Eastern Europe

    Science.gov (United States)

    Sledzinski, J.

    2003-04-01

    The European project EUPOS (European Position Determination System) of establishment of a system of multifunctional satellite reference stations in Central and Eastern Europe is described in the paper. Fifteen countries intend to participate in the project: Bulgaria, Croatia, Czech Republic, Estonia, Germany, Hungary, Latvia, Lithuania, Macedonia, Poland, Romania, Russia, Serbia, Slovak Republic and Slovenia. One common project will be prepared for all countries, however it will include the existing or developed infrastructure in particular countries. The experiences of establishing and operating of the German network SAPOS as well as experiences gained by other countries will be used. The European network of stations will be compatible with the system SAPOS and future European system Galileo. The network of reference stations will provide signal for both positioning of the geodetic control points and for land, air and marine navigation. Several levels of positioning accuracy will be delivered.

  14. Tolerance of the central nervous system to photon irradiation. Endocrine complications

    Energy Technology Data Exchange (ETDEWEB)

    Wigg, D.R.; Murray, R.M.L.; Koschel, K. (Royal Adelaide Hospital (Australia))

    1982-01-01

    Dose-response isoeffect equations have been determined for hypothalamic pituitary insufficiency following cranial irradiation. Of particular importance is the occurrence of complications at doses substantially less than those commonly used for the treatment of central nervous system tumors. Such complications may be severe and potentially life threatening. These complications occur when a small midline 'target' volume containing the pituitary gland, infundibulum and adjacent inferior hypothalamic structures is irradiated. Direct pituitary irradiation is unlikely to be a factor, at least in some cases. The possible role of incidental hypothalamic irradiation in the control of acromegaly and pituitary dependent Cushing's syndrome is discussed.

  15. Chondroitin sulfates and their binding molecules in the central nervous system.

    Science.gov (United States)

    Djerbal, L; Lortat-Jacob, H; Kwok, Jcf

    2017-06-01

    Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases.

  16. Central nervous system tuberculosis | Cherian | African Health ...

    African Journals Online (AJOL)

    Central nervous system (CNS) involvement, one of the most devastating clinical manifestations of tuberculosis (TB) is noted in 5 to 10% of extrapulmonary TB cases, and accounts for approximately 1% of all TB cases. Definitive diagnosis of tuberculous meningitis (TBM) depends upon the detection of the tubercle bacilli in ...

  17. The hierarchy of essential CANDU reactor control functions in a distributed system

    International Nuclear Information System (INIS)

    Mercier, P.

    1980-01-01

    Control functions in CANDU nuclear generating stations are programmed within two centralized and redundant minicomputers while safety functions are covered by conventional analog systems. This set-up is a product of standards, economic and technical considerations which are now being modified by the maturing of microprocessors, the progress in digital communications and the development of mathematical process models. Starting from the control and safety systems installed in Gentilly-2, this paper analyses trends that will affect the implementation of essential control functions within a distributed system. In particular, it emphasizes the characteristics of future software systems that must be built-in in order to comply with important operational requirements of nuclear generating stations. (auth) [fr

  18. Immune system modulation in the central nervous system: A possible role for endocannabinoids

    International Nuclear Information System (INIS)

    Abd-Allah, Adel R.A.

    2007-01-01

    The immune system is designed to protect the body from infection and tumor formation. To perform this function, cells of the immune system can be dangerous for the survival and function of the neuronal network in the brain under the influence of infection or immune imbalance. An attack of immune cells inside the brain includes the potential for severe neuronal damage or cell death and therefore impairment of the CNS function. To avoid such undesirable action of the immune system, the CNS performs a cascade of cellular and molecular mechanisms enabling strict control of immune reactions i mmune privilege . Under inflammatory and patholological conditions, uncontrolled immune system results in the activation of neuronal damage that is frequently associated with neurological diseases. On the other hand, processes of neuroprotection and neurorepair after neuronal damage depend on a steady and tightly controlled immunesurvelliance. Many immunoprotectants play a role to imbalance the immune reactions in the CNS and other organs which presents an important therapeutic target. It has been reported recently that endocannabinoids are secreted in abundance in the CNS following neuronal insult, probably for its protection. There are at least two types of cannabinoid receptors, CB1 and CB2. Both are coupled to G proteins. CB1 receptors exist primarily on central and peripheral neurons. CB2 receptors are present mainly on immune cells. Endogenous agonists for cannabinoid receptors (endocannabinoids), have been discovered, the most important being arachidonoyl ethanolamide (anandamide), 2-arachidonoyl glycerol (2AG), and 2-archidonyl glyceryl ether. Following their release, endocannabinoids are removed from the extracellular space and then degraded by intracellular enzymic hydrolysis. Therapeutic uses of cannabinoid receptor agonists/antagonists include the management of many disease conditions. They are also involved in immune system suppression and in cell to cell communication

  19. Performance enhancement of photovoltaic array through string and central based MPPT system under non-uniform irradiance conditions

    International Nuclear Information System (INIS)

    Syafaruddin; Karatepe, Engin; Hiyama, Takashi

    2012-01-01

    Highlights: ► We propose MPPT method for tracking global MPP of PV arrays under non-uniform irradiance conditions. ► We compare the performance of string and central based MPPT. ► Intelligent control method is utilized to identify the global operating voltage in string and central based MPPT system. ► The performance of proposed method is tested on different size of PV. - Abstract: Mismatching losses reduction of photovoltaic (PV) array has been intensively discussed through the increasing penetration of residential and commercial PV systems. Many causes of mismatching losses have been identified and plenty of proposed methods to solve this problem have been recently proposed. This paper deals with reducing method of mismatching losses due to the non-uniform irradiance conditions. It is well-known that a certain number of multiple peaks occur on the power–voltage curve as the number of PV modules in one-string increases under non-uniform operating conditions. Since the conventional control method only drives the operating points of PV system to the local maxima close to open circuit voltage, only small portion of power can be extracted from the PV system. In this study, a radial basis function neural network (RBF-ANN) based intelligent control method is utilized to map the global operating voltage and non-irradiance operating condition in string and central based MPPT systems. The proposed method has been tested on 10 × 3 (2.2 kW), 15 × 3 (2.5 kW) and 20 × 3 (3.3 kW) of series–parallel PV array configuration under random-shaded and continuous-shaded patterns. The proposed method is compared with the ideal case and conventional method through a simple power–voltage curve of PV arrays. The simulation results show that there are significant increases of about 30–60% of the extracted power in one operating condition when the proposed method is able to shift the operating voltage of modules to their optimum voltages.

  20. Central nervous system infections in heart transplant recipients

    NARCIS (Netherlands)

    van de Beek, Diederik; Patel, Robin; Daly, Richard C.; McGregor, Christopher G. A.; Wijdicks, Eelco F. M.

    2007-01-01

    OBJECTIVE: To study central nervous system infections after heart transplantations. DESIGN: Retrospective cohort study. SETTING: Cardiac Transplant Program at Mayo Clinic, Rochester, Minnesota. Patients Three hundred fifteen consecutive patients who underwent heart transplantation from January 1988

  1. Investigating Crustal Scale Fault Systems Controlling Volcanic and Hydrothermal Fluid Processes in the South-Central Andes, First Results from a Magnetotelluric Survey

    Science.gov (United States)

    Pearce, R.; Mitchell, T. M.; Moorkamp, M.; Araya, J.; Cembrano, J. M.; Yanez, G. A.; Hammond, J. O. S.

    2017-12-01

    At convergent plate boundaries, volcanic orogeny is largely controlled by major thrust fault systems that act as magmatic and hydrothermal fluid conduits through the crust. In the south-central Andes, the volcanically and seismically active Tinguiririca and Planchon-Peteroa volcanoes are considered to be tectonically related to the major El Fierro thrust fault system. These large scale reverse faults are characterized by 500 - 1000m wide hydrothermally altered fault cores, which possess a distinct conductive signature relative to surrounding lithology. In order to establish the subsurface architecture of these fault systems, such conductivity contrasts can be detected using the magnetotelluric method. In this study, LEMI fluxgate-magnetometer long-period and Metronix broadband MT data were collected at 21 sites in a 40km2 survey grid that surrounds this fault system and associated volcanic complexes. Multi-remote referencing techniques is used together with robust processing to obtain reliable impedance estimates between 100 Hz and 1,000s. Our preliminary inversion results provide evidence of structures within the 10 - 20 km depth range that are attributed to this fault system. Further inversions will be conducted to determine the approximate depth extent of these features, and ultimately provide constraints for future geophysical studies aimed to deduce the role of these faults in volcanic orogeny and hydrothermal fluid migration processes in this region of the Andes.

  2. Access control within military C4ISR systems

    Science.gov (United States)

    Maschino, Mike

    2003-07-01

    Command, Control, Communications, Computers, Intelligence, Surveillance and Reconnaissance (C4ISR) tactical battlefield systems must provide the right information and resources to the right individuals at the right time. At the same time, the C4ISR system must enforce access controls to prevent the wrong individuals from obtaining sensitive information, or consuming scarce resources. Because lives, missions and property depend upon them, these access control mechanisms must be effective, reliable, efficient and flexible. The mechanisms employed must suit the nature of the items that are to be protected, as well as the varieties of access policies that must be enforced, and the types of access that will be made to these items. Some access control technologies are inherently centralized, while others are suitable for distributed implementation. The C4ISR architect must select from among the available technologies a combination of mechanisms that eases the burden of policy administration, but is inherently survivable, accurate, resource efficient, and which provides low latency. This paper explores various alternative access enforcement mechanisms, and assesses their effectiveness in managing policy-driven access control within the battlespace.

  3. Automatic Voltage Control (AVC) of Danish Transmission System - Concept design

    DEFF Research Database (Denmark)

    Qin, Nan; Abildgaard, Hans; Lund, P.

    2014-01-01

    For more than 20 years it has been a consistent plan by all Danish governments to turn the Danish power production away from fossil fuels towards renewable energy. The result today is that 37% of the total Danish power consumption was covered by mainly wind energy in 2013 aiming at 50% by 2020......, objectives, constraints, algorithms for optimal power flow and some special functions in particular systems, which inspires the concept design of a Danish AVC system to address the future challenges of voltage control. In the concept, the Danish AVC design is based on a centralized control scheme. All...... the substation loses the telecommunications to the control center. RPCs will be integrated to the AVC system as normative regulators in the later stage. Distributed generation units can be organized as virtual power plants and participate in voltage control at transmission level. Energinet.dk as the Danish TSO...

  4. Primary central nervous system lymphoma: is absence of intratumoral hemorrhage a characteristic finding on MRI?

    Science.gov (United States)

    Sakata, Akihiko; Okada, Tomohisa; Yamamoto, Akira; Kanagaki, Mitsunori; Fushimi, Yasutaka; Dodo, Toshiki; Arakawa, Yoshiki; Takahashi, Jun C; Miyamoto, Susumu; Togashi, Kaori

    2015-06-01

    Previous studies have shown that intratumoral hemorrhage is a common finding in glioblastoma multi-forme, but is rarely observed in primary central nervous system lymphoma. Our aim was to reevaluate whether intratumoral hemorrhage observed on T2-weighted imaging (T2WI) as gross intratumoral hemorrhage and on susceptibility-weighted imaging as intratumoral susceptibility signal can differentiate primary central nervous system lymphoma from glioblastoma multiforme. A retrospective cohort of brain tumors from August 2008 to March 2013 was searched, and 58 patients (19 with primary central nervous system lymphoma, 39 with glioblastoma multiforme) satisfied the inclusion criteria. Absence of gross intratumoral hemorrhage was examined on T2WI, and an intratumoral susceptibility signal was graded using a 3-point scale on susceptibility-weighted imaging. Results were compared between primary central nervous system lymphoma and glioblastoma multiforme, and values of P central nervous system lymphoma and 23 patients (59%) with glioblastoma multiforme. Absence of gross intratumoral hemorrhage could not differentiate between the two disorders (P = 0.20). However, intratumoral susceptibility signal grade 1 or 2 was diagnostic of primary central nervous system lymphoma with 78.9% sensitivity and 66.7% specificity (P central nervous system lymphoma from glioblastoma multiforme. However, specificity in this study was relatively low, and primary central nervous system lymphoma cannot be excluded based solely on the presence of an intratumoral susceptibility signal.

  5. System composition and operation of exposure dose registration and control system (Final report)

    International Nuclear Information System (INIS)

    1978-01-01

    Since November, 1976, the committee concerning the investigation of exposure dose registration and control system for employees in nuclear industries has discussed on the exposure dose registration and control system, issued the interim report (outline) in April, 1977, and continued to investigate the details organizing the working group. Here, the final report is presented. It describes first on the definition of the terms used and the basic concept of the exposure dose registration and control system, in which the name of that organization is decided as ''Central Registration Office for Radiation Works'', Radiation Influence Association, the foundational juridical person. Next, the works to be performed in the Center and nuclear energy enterprises are explained. The items concerning the business management at the time of practical execution are the major part of the report, and are over 22 items. These include the registration business, the official reporting business, inquiry and answer business about career, change and revision, and computer processing system. As the temporary measures for transfer ring to the new system, 10 items are also provided. Supplementary explanation of 9 important items is given in the appendix. (Wakatsuki, Y.)

  6. Development and application of automatic frequency and power control systems for large power units

    Energy Technology Data Exchange (ETDEWEB)

    V.A. Bilenko; A.D. Melamed; E.E. Mikushevich; D.Y. Nikol' skii; R.L. Rogachev; N.A. Romanov [ZAO Interavtomatika (Interautomatika AG), Moscow (Russian Federation)

    2008-07-01

    We describe the results of work carried out at ZAO Interavtomatika on the development and putting into use of a system for automatically controlling the frequency and power output of large coal-fired power units involving the retrofitting of the turbine's hydraulic automatic control system. Certificates affirming conformity to the Standard of the System Operator Centralized Dispatching Administration (SO-CDA) have been received for eight power units as an outcome of these efforts.

  7. Control system for nuclear power plant

    International Nuclear Information System (INIS)

    Sato, Takahisa; Kawahara, Haruo.

    1979-01-01

    Purpose: To save man power and improve operation reliability by enabling automatic selection and operation of control rods from a central processing unit by the input operation of an operator. Constitution: An input operation for the control information corresponding to the running conditions such as operation sequence of control rods and loading-unloading positions is effected using a light pen or the like on a CRT display device. The signal from the light pen is supplied by way of the CRT control device to the input of a central processing unit and the control rod selection signal and the load-unload signal are supplied to the input of a control rod driving circuit. A control signal is sent out from the above circuit so as to enable the same operation as set by the operator, whereby the control rod is driven. The control rod is displaced on the cathode ray tube. (Furukawa, Y.)

  8. Experimental evidence of a dual endocrine control of biosynthesis in the main nidamental glands of Sepia officinalis L. by factors from the central nervous system and the ovary.

    Science.gov (United States)

    Henry, J; Boucaud-Camou, E

    1993-12-01

    1. A rapid, reliable and quantitative in vitro bioassay was developed to study the endocrine control of the biosynthesis of the egg capsule: incorporation of 14C-labelled D-glucose in polysaccharides and glycoproteins increased in dispersed-cell suspensions of main nidamental glands from maturing females. 2. Brain, optic lobes (OL) and ovary extracts from mature and maturing females stimulated the incorporation of 14C-labelled D-glucose in polysaccharidic and glycoproteic fractions of a nidamental cell suspension, whereas optic gland (OG) had no effect. 3. These results bring the first experimental evidence that one of the spawning events (egg-capsule edification) is controlled by the central nervous system and the ovary in a cephalopod.

  9. Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA

    DEFF Research Database (Denmark)

    Weng, Ruifen; Cohen, Stephen M

    2015-01-01

    Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferat......Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports...

  10. The efficacy of centralized flow rate control in 802.11-based wireless mesh networks

    KAUST Repository

    Jamshaid, K.

    2013-06-13

    Commodity WiFi-based wireless mesh networks (WMNs) can be used to provide last mile Internet access. These networks exhibit extreme unfairness with backlogged traffic sources. Current solutions propose distributed source-rate control algorithms requiring link-layer or transport-layer changes on all mesh nodes. This is often infeasible in large practical deployments. In wireline networks, router-assisted rate control techniques have been proposed for use alongside end-to-end mechanisms. We wish to evaluate the feasibility of establishing similar centralized control via gateways in WMNs. In this paper, we focus on the efficacy of this control rather than the specifics of the controller design mechanism. We answer the question: Given sources that react predictably to congestion notification, can we enforce a desired rate allocation through a single centralized controller? The answer is not obvious because flows experience varying contention levels, and transmissions are scheduled by a node using imperfect local knowledge. We find that common router-assisted flow control schemes used in wired networks fail in WMNs because they assume that (1) links are independent, and (2) router queue buildups are sufficient for detecting congestion. We show that non-work-conserving, rate-based centralized scheduling can effectively enforce rate allocation. It can achieve results comparable to source rate limiting, without requiring any modifications to mesh routers or client devices. 2013 Jamshaid et al.; licensee Springer.

  11. Lipomas of the central nervous system in childhood. Apropos of 3 cases

    International Nuclear Information System (INIS)

    Delucchi Bottato, M.; Scavone Mauro, C.; Delfino Albornoz, A.

    2004-01-01

    Lipomas of the central nervous system occur as a phenomenon consequences developmental malformations of the central nervous system (CNS) and are not considered neoplasms . It is often associated with other congenital malformations. Representing 0.5 percent of intracranial tumors. Imaging studies are central CT or MRI for diagnosis. They are generally associated with other malformations of the CNS. The surgical treatment is always discussed by the high morbidity associated with it. We present three cases of children with lipomas of different topography. (author) [es

  12. 40 CFR 81.142 - Central Massachusetts Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central Massachusetts Intrastate Air Quality Control Region. 81.142 Section 81.142 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...: Township—Ashburnham, Ashby, Athol, Auburn, Barre, Berlin, Blackstone, Boylston, Brookfield, Charlton...

  13. 40 CFR 81.143 - Central Virginia Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central Virginia Intrastate Air Quality Control Region. 81.143 Section 81.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., Lynchburg, Martinsville, South Boston. Towns—Blackstone, Farmville, Rocky Mount, South Hill. ...

  14. Global voltage control for the LEP RF system

    International Nuclear Information System (INIS)

    Ciapala, E.; Butterworth, A.; Peschardt, E.

    1993-01-01

    The LEG RF system is installed as independent 16 cavity units. In addition to the eight copper cavity units originally installed 12 units with super-conducting cavities are being added for the LEP200 energy upgrade. The total RF voltage determines the synchrotron tune (Qs) and must be controlled precisely during energy ramping. Local function generators in each of the RF units are pre-loaded such that when triggered simultaneously by ramp timing events transmitted over the general timing system the total voltage varies to give the Qs function required. A disadvantage is that loss of RF in a unit at any time after the loading process cannot be corrected. As the number of RF units increases automatic control of the total RF voltage and its distribution around LEP becomes desirable. A global voltage control system, based on a central VME controller, has recently been installed. It has direct and rapid access to the RF units over the LEP time division multiplexing system. Initial tests on operation and performance at fixed energy and during energy ramping are described, as well as the implementation of a Qs loop in which Qs can be set directly using on-line synchrotron frequency measurements

  15. PAYMENT SYSTEMS AND THE ROLE OF THE CENTRAL BANK OF ROMANIA

    Directory of Open Access Journals (Sweden)

    MARIA VASILESCU

    2014-05-01

    Full Text Available The management of payment and settlement systems is one of the traditional functions of central banks that seeks to ensure financial stability. Similar to the case of other important function, that of lender of last resort, it is wise to ask ourselves whether the central bank is the best institution to manage payment systems. Also, considering the advances in the field, some questions arise: whether or not they contributed to the reduction of systemic risk?, do they bring extra liquidity and stability of the EMU scheme?.

  16. Progress in study on central nervous system injuries caused by obstructive sleep apnea syndrome

    Directory of Open Access Journals (Sweden)

    ZHAO Xiang-xiang

    2013-05-01

    Full Text Available Chronic and repetitive intermittent hypoxia and dysfunction of sleep architecture mainly contribute to obstructive sleep apnea syndrome (OSAS. More and more evidences demonstrate it is a systemic disease, which is common encountered in clinic and strongly related to the systemic lesion of central nervous system. The central nervous system complications comprise cognitive impairment, brain atrophy and the growing risk of stroke and so on. Early treatment for OSAS has a positive significance on complications of central nervous system, and even the damage can be completely reversed.

  17. Geologic controls on the formation of lakes in north-central Florida

    Science.gov (United States)

    Kindinger, Jack G.; Davis, Jeffrey B.; Flocks, James G.; Pitman, Janet K.; Carroll, Alan R.

    1998-01-01

    Fluid exchange between surficial waters and groundwater, as well as the processes that control this exchange, are of critical concern to water management districts and planners. Digital high-resolution seismic systems were used to collect geophysical data from 30 lakes of north-central Florida. Although using seismic profile data in the past has been less than successful, the use of digital technology has increased the potential for success. Seismic profiles collected from the lakes of north-central Florida have shown the potential application of these techniques in understanding the formation of individual lakes. In each case study, lake structure and geomorphology were controlled by solution and/or mechanical processes. Processes that control lake development are twofold: 1) karstification or dissolution of the underlying limestone, and 2) me collapse, subsidence, or slumping of overburden to form sinkholes. Initial lake formation is directly related to the karst topography of the underlying host limestone. Lake size and shape are a factor of the thickness of overburden and size of the collapse or subsidence and/or clustering of depressions allowing for lake development. Lake development is through progressive sequence stages to maturity that can be delineated into geomorphic types. Case studies have shown that lakes can be divided by geomorphic types into progressive developmental phases: (1) active subsidence or collapse phase (young) - the open to partially filled collapse structures typically associated with sink holes; (2) transitional phase (middle age) - the sinkhole is plugged as the voids within the collapse are filled with sediment, periodic reactivation may occur; (3) baselevel phase (mature) - active sinkholes are progressively plugged by the continual erosion of material into the basin, and eventually sediment fills the basins; and (4) polje (drowned prairie) - broad flat-bottom basins located within the epiphreatic zone that are inundated at high

  18. Central nervous system complications in non-Hodgkin-lymphomas and radiotherapy

    International Nuclear Information System (INIS)

    Liffers, R.

    1981-01-01

    261 case historys of malignant non-Hodgkin-lymphomas were analysed in the years from 1969 until 1978 in the 'Radiologische Universitaetsklinik Kiel'/West-Germany. 18 Patients got a central nervous complication of Non Hodgkin-Lymphoma earlier or later, a percentage of about 7. There were 7 cases of lymphoblastic lymphoma (LB), a percentage of 10 for this entity. In the group of immunoblastic lymphoma (IB) 6 cases of central nervous infiltration were detected, that is a ratio of 7.7 percent. 4 case histories M. Brill-Symmers (CC/CB) were complicated by central nervous dissemination, a percentage of 5.3. Patients with lymphoblastic lymphoma have the highest risk of central nervous complication. The beginning of central nervous dissemination in the single case histories is very different between the histological groups. Patients with lymphoblastic lymphoma suffered from central nervous complication in an early phase of history, in cases of M. Brill-Symmers central nervous infiltration can occur also in a late phase. The results may determine the discussion about stratifying of radiotherapy. Early radiotherapy including central nervous system may be discussed and investigated in special histological entities of malignant non-Hodgkin-lymphoma. (orig.) [de

  19. Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals.

    Science.gov (United States)

    Okamura, Hiroaki; Yamamura, Takashi; Wakabayashi, Yoshihiro

    2013-05-01

    The hypothalamo-pituitary-gonadal (HPG) axis is the regulatory system for reproduction in mammals. Because secretion of gonadotropin-releasing hormone (GnRH) into the portal vessels is the final step at which the brain controls gonadal activities, the GnRH neuronal system had been thought to be central to the HPG axis. A newly discovered neural peptide, kisspeptin, has opened a new era in reproductive neuroendocrinology. As shown in a variety of mammals, kisspeptin is a potent endogenous secretagogue of GnRH, and the kisspeptin neuronal system governs both the pulsatile GnRH secretion that drives folliculogenesis, spermatogenesis and steroidogenesis, and the GnRH surge that triggers ovulation in females. The kisspeptin neuronal system is therefore considered a master player in the central control of mammalian reproduction, and kisspeptin and related substances could therefore be valuable for the development of novel strategies for the management of fertility in farm animals. To this end, the present review aimed to summarize the current research on kisspeptin signaling with a focus on domestic animals such as sheep, goats, cattle, pigs and horses. © 2013 Japanese Society of Animal Science.

  20. Lipomas of the central nervous system in the newborns – a report of eight cases

    International Nuclear Information System (INIS)

    Gradowska, Kinga; Czech-Kowalska, Justyna; Jurkiewicz, Elżbieta; Komornicka, Justyna; Dobrzańska, Anna

    2011-01-01

    Central nervous system lipomas are rare tumours. In most of the cases they are located in corpus callosum of the brain. The ultrasonographic image of lipomas tends to be quite characteristic. Final diagnosis is however done on a basis of brain resonance. The purpose of this work is to present proceeding in case of central nervous system lipomas with particular attention to diagnostic imaging. This work is based on own research. There are eight patients with central nervous system lipomas described in this work. The ultrasonographic imaging performed upon patients’ birth revealed features of agenesis of corpus callosum with presence of hyperechoic structure in the area of median line within corpus callosum. This image correlated with Nuclear Magnetic Resonance examination results. Our research confirms that patients with central nervous system lipomas represent rare diagnostic and therapeutic cases. Due to characteristic results of ultrasonographic imaging of the brain, recognition of agenesis of corpus callosum would not cause difficulties. However the presence of hyperechoic structure without vascular flow which may suggest lipomas of corpus callosum would require final verification of the diagnosis and wider assessment of brain with NMR examination. We did not recognize any relation between corpus callosum pathology and neuroinfection of cytomegalovirus etiology. In all of the eight research cases there were malformations diagnostics conducted. There were genetic irregularities in case of two of the neonates only. Until today, all of the patients remain under neurological care. Their psychomotor development is regularly controlled. Taking into consideration that numerous malformations occur altogether with brain lipomas, it is recommended to conduct appropriate diagnostics, to inform parents on an essence of diagnosis and on necessity of observing child’s psychomotor development. Obviously, it is crucial to secure a patient with paediatric and neurological

  1. Radon exposure and tumors of the central nervous system.

    Science.gov (United States)

    Ruano-Ravina, Alberto; Dacosta-Urbieta, Ana; Barros-Dios, Juan Miguel; Kelsey, Karl T

    2017-03-15

    To review the published evidence of links between radon exposure and central nervous system tumors through a systematic review of the scientific literature. We performed a thorough bibliographic search in Medline (PubMed) and EMBASE. We combined MeSH (Medical Subject Heading) terms and free text. We developed a purpose-designed scale to assess the quality of the included manuscripts. We have included 18 studies, 8 performed on miners, 3 on the general population and 7 on children, and the results have been structured using this classification. The results are inconclusive. An association between radon exposure and central nervous system tumors has been observed in some studies on miners, but not in others. The results observed in the general adult population and in children are also mixed, with some research evincing a statistically significant association and others showing no effect. We cannot conclude that there is a relationship between radon exposure and central nervous system tumors. The available studies are extremely heterogeneous in terms of design and populations studied. Further research is needed in this topic, particularly in the general population residing in areas with high levels of radon. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. [The Role of Imaging in Central Nervous System Infections].

    Science.gov (United States)

    Yokota, Hajime; Tazoe, Jun; Yamada, Kei

    2015-07-01

    Many infections invade the central nervous system. Magnetic resonance imaging (MRI) is the main tool that is used to evaluate infectious lesions of the central nervous system. The useful sequences on MRI are dependent on the locations, such as intra-axial, extra-axial, and spinal cord. For intra-axial lesions, besides the fundamental sequences, including T1-weighted images, T2-weighted images, and fluid-attenuated inversion recovery (FLAIR) images, advanced sequences, such as diffusion-weighted imaging, diffusion tensor imaging, susceptibility-weighted imaging, and MR spectroscopy, can be applied. They are occasionally used as determinants for quick and correct diagnosis. For extra-axial lesions, understanding the differences among 2D-conventional T1-weighted images, 2D-fat-saturated T1-weighted images, 3D-Spin echo sequences, and 3D-Gradient echo sequence after the administration of gadolinium is required to avoid wrong interpretations. FLAIR plus gadolinium is a useful tool for revealing abnormal enhancement on the brain surface. For the spinal cord, the sequences are limited. Evaluating the distribution and time course of the spinal cord are essential for correct diagnoses. We summarize the role of imaging in central nervous system infections and show the pitfalls, key points, and latest information in them on clinical practices.

  3. Effect of the crone suspension control system on braking

    Energy Technology Data Exchange (ETDEWEB)

    Moreau, X.; Oustaloup, A. [Bordeaux-1 Univ., Talence (France). Lab. d' Automatique et de Productique; Nouillant, C. [Bordeaux-1 Univ., Talence (France). Lab. d' Automatique et de Productique]|[DRIA-PSA Peugeot Citroen, Velizy - Villacoublay (France)

    2001-07-01

    Semi-active or active suspensions not only increase driving comfort, but also permit the control system to be switched over if required in order to improve the transmission of forces at the points of contact between tire and road surface by minimizing the dynamic wheel loads. It may also be possible to use these systems to control wheel load distribution and, thus, influence braking or steering performance by changing the distribution of normal forces between the front and rear axles. This article examines the effect of the CRONE suspension control system on braking. The central idea is to use continuously variable dampers and fast load levelling devices to distribute the normal forces of tire between the front and rear axles. The basis principle is explained using known dynamic properties of active suspension, vehicles and tires. The effect of active suspension on vehicle response during braking is then evaluated using computer simulations from a two-wheel vehicle model. (orig.)

  4. Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases.

    Science.gov (United States)

    De Luca, Ciro; Virtuoso, Assunta; Maggio, Nicola; Papa, Michele

    2017-10-12

    Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central nervous system (CNS). The protease-activated receptors (PARs) pathway can be considered the central hub of this regulatory network, mainly through thrombin or activated protein C (aPC). These proteins, in fact, showed peculiar properties, being able to interfere with synaptic homeostasis other than coagulation itself. These specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix. The pleiotropy of these effects is produced through different receptors, expressed in various cell types, in a dose- and time-dependent pattern. We reviewed how these pathways may be involved in neurodegenerative diseases (amyotrophic lateral sclerosis, Alzheimer's and Parkinson's diseases), multiple sclerosis, ischemic stroke and post-ischemic epilepsy, CNS cancer, addiction, and mental health. These data open up a new path for the potential therapeutic use of the agonist/antagonist of these proteins in the management of several central nervous system diseases.

  5. Control and data acquisition system for versatile experiment spherical torus at SNU

    Energy Technology Data Exchange (ETDEWEB)

    An, YoungHwa [Department of Nuclear Engineering, Seoul National University, Seoul 151-742 (Korea, Republic of); Chung, Kyoung-Jae, E-mail: jkjlsh1@snu.ac.kr [Department of Nuclear Engineering, Seoul National University, Seoul 151-742 (Korea, Republic of); Na, DongHyeon; Hwang, Y.S. [Department of Nuclear Engineering, Seoul National University, Seoul 151-742 (Korea, Republic of)

    2013-10-15

    A control and data acquisition system for VEST (Versatile Experiment Spherical Torus) at Seoul National University (SNU) has been developed to enable remote operation from a central control room. The control and data acquisition system consists of three subsystems; a main control and data acquisition system that triggers each device at the preprogrammed timing and collects various diagnostic signals during discharges, a monitoring system that watches and logs the device status continuously, and a data storage and distribution system that stores collected data and provides data access layer via Ethernet. The system is designed to be cost-effective, extensible and easy to develop by using well-established standard technologies and solutions. Combining broad accessibility with modern information technology, alarm signal can be sent immediately to the registered cell phones when the abnormal status of devices is found, and the web data distribution system enables data access from almost everywhere using smart phones or tablet computers. Since December 2011, VEST is operational and the control and data acquisition system has been successfully used for remote operation of VEST.

  6. Control and data acquisition system for versatile experiment spherical torus at SNU

    International Nuclear Information System (INIS)

    An, YoungHwa; Chung, Kyoung-Jae; Na, DongHyeon; Hwang, Y.S.

    2013-01-01

    A control and data acquisition system for VEST (Versatile Experiment Spherical Torus) at Seoul National University (SNU) has been developed to enable remote operation from a central control room. The control and data acquisition system consists of three subsystems; a main control and data acquisition system that triggers each device at the preprogrammed timing and collects various diagnostic signals during discharges, a monitoring system that watches and logs the device status continuously, and a data storage and distribution system that stores collected data and provides data access layer via Ethernet. The system is designed to be cost-effective, extensible and easy to develop by using well-established standard technologies and solutions. Combining broad accessibility with modern information technology, alarm signal can be sent immediately to the registered cell phones when the abnormal status of devices is found, and the web data distribution system enables data access from almost everywhere using smart phones or tablet computers. Since December 2011, VEST is operational and the control and data acquisition system has been successfully used for remote operation of VEST

  7. Central Hemodynamics and Arterial Stiffness in Systemic Sclerosis.

    Science.gov (United States)

    Bartoloni, Elena; Pucci, Giacomo; Cannarile, Francesca; Battista, Francesca; Alunno, Alessia; Giuliani, Marco; Cafaro, Giacomo; Gerli, Roberto; Schillaci, Giuseppe

    2016-12-01

    Although microvascular disease is a hallmark of systemic sclerosis (SSc), a higher prevalence of macrovascular disease and a poorer related prognosis have been reported in SSc than in the general population. The simultaneous assessment of prognostically relevant functional properties of larger and smaller arteries, and their effects on central hemodynamics, has never been performed in SSc using the state-of-the-art techniques. Thirty-four women with SSc (aged 61±15 years, disease duration 17±12 years, and blood pressure 123/70±18/11 mm Hg) and 34 healthy women individually matched by age and mean arterial pressure underwent the determination of carotid-femoral (aortic) and carotid-radial (upper limb) pulse wave velocity (a direct measure of arterial stiffness), aortic augmentation (a measure of the contribution of reflected wave to central pulse pressure), and aortobrachial pulse pressure amplification (brachial/aortic pulse pressure) through applanation tonometry (SphygmoCor). Patients and controls did not differ by carotid-femoral or carotid-radial pulse wave velocity. Aortic augmentation index corrected for a heart rate of 75 bpm (AIx@75) was higher in women with SSc (30.9±16% versus 22.2±12%; P=0.012). Patients also had a lower aortobrachial amplification of pulse pressure (1.22±0.18 versus 1.33±0.25; P=0.041). SSc was an independent predictor of AIx@75 (direct) and pulse pressure amplification (inverse). Among patients, age, mean arterial pressure, and C-reactive protein independently predicted carotid-femoral pulse wave velocity. Age and mean arterial pressure were the only predictors of AIx@75. Women with SSc have increased aortic augmentation and decreased pulse pressure amplification (both measures of the contribution of reflected wave to central waveform) but no changes in aortic or upper limb arterial stiffness. Microvascular involvement occurs earlier than large artery stiffening in SSc. © 2016 American Heart Association, Inc.

  8. Behavioural conditioning of immune functions: how the central nervous system controls peripheral immune responses by evoking associative learning processes.

    Science.gov (United States)

    Riether, Carsten; Doenlen, Raphaël; Pacheco-López, Gustavo; Niemi, Maj-Britt; Engler, Andrea; Engler, Harald; Schedlowski, Manfred

    2008-01-01

    During the last 30 years of psychoneuroimmunology research the intense bi-directional communication between the central nervous system (CNS) and the immune system has been demonstrated in studies on the interaction between the nervous-endocrine-immune systems. One of the most intriguing examples of such interaction is the capability of the CNS to associate an immune status with specific environmental stimuli. In this review, we systematically summarize experimental evidence demonstrating the behavioural conditioning of peripheral immune functions. In particular, we focus on the mechanisms underlying the behavioural conditioning process and provide a theoretical framework that indicates the potential feasibility of behaviourally conditioned immune changes in clinical situations.

  9. German Democratic Republic State system of accounting for and control of nuclear material

    International Nuclear Information System (INIS)

    Roehnsch, W.; Gegusch, M.

    1976-01-01

    The system of accountancy for and control of nuclear material in the German Democratic Republic (GDR) with its legal bases and components is embedded in the overall State system of protection in the peaceful uses of nuclear energy. As the competent State authority, the Nuclear Safety and Radiation Protection Board of the GDR is also responsible for meeting the GDR's national and international tasks in the control of nuclear material. At enterprise level, the observance of all safety regulations for nuclear material, including the regulations for the control, is within the responsibility of managers of establishments, which are in any way concerned with the handling of nuclear material. To support managers and to function as internal control authorities, nuclear material officers have been appointed in these establishments. Design information, operating data, physical inventory of nuclear material and the respective enterprise records and reports are subject to State control by the Nuclear Material Inspectorate of the Nuclear Safety and Radiation Protection Board. This Inspectorate keeps the central records on nuclear material, forwards reports and information to, and maintains the necessary contacts with, the IAEA. For the nuclear material in the GDR four material balance areas have been established for control purposes. To rationalize central recording and reporting, electronic data processing is increasingly made use of. In a year-long national and international control of nuclear material, the State control system has stood the test and successfully co-operates with the IAEA. (author)

  10. Status of control systems for industrial electron accelerators at EBC, Kharghar

    International Nuclear Information System (INIS)

    Jain, Arvind; Kumar, Mukesh; Kaurav, P.S.; Sharma, Vijay; Chawla, A.S.; Sethi, R.C.

    2005-01-01

    The Bhabha Atomic Research Centre (BARC) is setting up two industrial electron accelerators at the Electron Beam Center (EBC) Kharghar. These are a 10 MeV, 10 KW beam power RF linac and a 30 KW, DC, Dynamitron type of machine. The present status of the control systems of these accelerators are presented. Some novel features in the design of the control system include (a) the software and hardware of the control system has been designed such that the same package can be used for the two widely different machines. Thus the control system developed can be used for any new accelerator also by reformatting the built in data base (b) an attempt is being made towards push button operation to minimize the need for machine operators. This is achieved by a sequential start-up and shut down procedure with appropriate time lags built into the software. The PC based centralized control system has been tested and now gives automated operation of the 22 sub-systems of the linac and operating experience of the system for the last one year has been achieved. Similarly, the control system of the 3 MeV DC machine having about 20 subsystems are in the final stage of commissioning and testing. (author)

  11. Submerged reef systems on the central western continental shelf of India

    Digital Repository Service at National Institute of Oceanography (India)

    Vora, K.H.; Almeida, F.

    -262 255 Elsevier Science Publishers B.V., Amsterdam -- Printed in the Netherlands Letter Section Submerged Reef Systems on the Central Western Continental Shelf of India K.H. VORA and F. ALMEIDA National Institute of Oceanography, Dona Paula, Goa 403... 004 (India) (Revision accepted October 26, 1989) Abstract Vora, K.H. and Almeida, F., 1990. Submerged reef systems on the central western continental shelf of India. Mar. Geol., 91: 255-262. Echosounding and sidescan sonar data from the western...

  12. A pediatric renal lymphoma case presenting with central nervous system findings.

    Science.gov (United States)

    Baran, Ahmet; Küpeli, Serhan; Doğru, Omer

    2013-06-01

    In pediatric patients renal lymphoma frequently presents in the form of multiple, bilateral mass lesions, infrequently as a single or retroperitoneal mass, and rarely as diffuse infiltrative lesions. In patients with apparent central nervous system involvement close attention to other physical and laboratory findings are essential for preventing a delay in the final diagnosis. Herein we present a pediatric patient with renal lymphoma that presented with central nervous system findings that caused a delay in diagnosis. None declared.

  13. Effects of tilting on central hemodynamics and homeostatic mechanisms in cirrhosis

    DEFF Research Database (Denmark)

    Møller, Søren; Nørgaard, Annette; Henriksen, Jens H

    2004-01-01

    Patients with cirrhosis have a hyperdynamic circulation and an abnormal blood volume distribution with central hypovolemia, an activated sympathetic nervous system (SNS) as well as the renin-angiotensin-aldosterone system (RAAS). As the hyperdynamic circulation in cirrhosis may be present only...... in the supine patient, we studied the humoral and central hemodynamic responses to changes with posture. Twenty-three patients with alcoholic cirrhosis (Child-Turcotte-Pugh classes A/B/C: 2/13/8) and 14 healthy controls were entered. Measurements of central hemodynamics and activation of SNS and RAAS were taken......). Central circulation time increased only in the patients (+30% vs. -1%, P higher in the patients than in the controls (P

  14. [Primary malignant melanoma of the central nervous system: A diagnostic challenge].

    Science.gov (United States)

    Quillo-Olvera, Javier; Uribe-Olalde, Juan Salvador; Alcántara-Gómez, Leopoldo Alberto; Rejón-Pérez, Jorge Dax; Palomera-Gómez, Héctor Guillermo

    2015-01-01

    The rare incidence of primary malignant melanoma of the central nervous system and its ability to mimic other melanocytic tumors on images makes it a diagnostic challenge for the neurosurgeon. A 51-year-old patient, with a tumor located in the right forniceal callosum area. Total surgical excision was performed. Histopathological result was consistent with the diagnosis of primary malignant melanoma of the central nervous system, after ruling out extra cranial and extra spinal melanocytic lesions. The primary malignant melanoma of the central nervous system is extremely rare. There are features in magnetic resonance imaging that increase the diagnostic suspicion; nevertheless there are other tumors with more prevalence that share some of these features through image. Since there is not an established therapeutic standard its prognosis is discouraging. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  15. Central FPGA-based destination and load control in the LHCb MHz event readout

    International Nuclear Information System (INIS)

    Jacobsson, R.

    2012-01-01

    The readout strategy of the LHCb experiment is based on complete event readout at 1 MHz. A set of 320 sub-detector readout boards transmit event fragments at total rate of 24.6 MHz at a bandwidth usage of up to 70 GB/s over a commercial switching network based on Gigabit Ethernet to a distributed event building and high-level trigger processing farm with 1470 individual multi-core computer nodes. In the original specifications, the readout was based on a pure push protocol. This paper describes the proposal, implementation, and experience of a non-conventional mixture of a push and a pull protocol, akin to credit-based flow control. An FPGA-based central master module, partly operating at the LHC bunch clock frequency of 40.08 MHz and partly at a double clock speed, is in charge of the entire trigger and readout control from the front-end electronics up to the high-level trigger farm. One FPGA is dedicated to controlling the event fragment packing in the readout boards, the assignment of the farm node destination for each event, and controls the farm load based on an asynchronous pull mechanism from each farm node. This dynamic readout scheme relies on generic event requests and the concept of node credit allowing load control and trigger rate regulation as a function of the global farm load. It also allows the vital task of fast central monitoring and automatic recovery in-flight of failing nodes while maintaining dead-time and event loss at a minimum. This paper demonstrates the strength and suitability of implementing this real-time task for a very large distributed system in an FPGA where no random delays are introduced, and where extreme reliability and accurate event accounting are fundamental requirements. It was in use during the entire commissioning phase of LHCb and has been in faultless operation during the first two years of physics luminosity data taking.

  16. Central FPGA-based destination and load control in the LHCb MHz event readout

    Science.gov (United States)

    Jacobsson, R.

    2012-10-01

    The readout strategy of the LHCb experiment is based on complete event readout at 1 MHz. A set of 320 sub-detector readout boards transmit event fragments at total rate of 24.6 MHz at a bandwidth usage of up to 70 GB/s over a commercial switching network based on Gigabit Ethernet to a distributed event building and high-level trigger processing farm with 1470 individual multi-core computer nodes. In the original specifications, the readout was based on a pure push protocol. This paper describes the proposal, implementation, and experience of a non-conventional mixture of a push and a pull protocol, akin to credit-based flow control. An FPGA-based central master module, partly operating at the LHC bunch clock frequency of 40.08 MHz and partly at a double clock speed, is in charge of the entire trigger and readout control from the front-end electronics up to the high-level trigger farm. One FPGA is dedicated to controlling the event fragment packing in the readout boards, the assignment of the farm node destination for each event, and controls the farm load based on an asynchronous pull mechanism from each farm node. This dynamic readout scheme relies on generic event requests and the concept of node credit allowing load control and trigger rate regulation as a function of the global farm load. It also allows the vital task of fast central monitoring and automatic recovery in-flight of failing nodes while maintaining dead-time and event loss at a minimum. This paper demonstrates the strength and suitability of implementing this real-time task for a very large distributed system in an FPGA where no random delays are introduced, and where extreme reliability and accurate event accounting are fundamental requirements. It was in use during the entire commissioning phase of LHCb and has been in faultless operation during the first two years of physics luminosity data taking.

  17. Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis

    DEFF Research Database (Denmark)

    Møller, S; Bendtsen, F; Henriksen, Jens Henrik Sahl

    1995-01-01

    , and arterial pressure were determined before and during a volume expansion induced by infusion of a hyperosmotic galactose solution. RESULTS: During volume expansion, the central and arterial blood volume increased significantly in patients with class A and controls, whereas no significant change was found...... in patients with either class B or class C. Conversely, the noncentral blood volume increased in patients with class B and C. In both patients and controls, the cardiac output increased and the systemic vascular resistance decreased, whereas the mean arterial blood pressure did not change significantly......BACKGROUND & AIMS: Systemic vasodilatation in cirrhosis may lead to hemodynamic alterations with reduced effective blood volume and decreased arterial blood pressure. This study investigates the response of acute volume expansion on hemodynamics and regional blood volumes in patients with cirrhosis...

  18. Controlling Underwater Robots with Electronic Nervous Systems

    Directory of Open Access Journals (Sweden)

    Joseph Ayers

    2010-01-01

    Full Text Available We are developing robot controllers based on biomimetic design principles. The goal is to realise the adaptive capabilities of the animal models in natural environments. We report feasibility studies of a hybrid architecture that instantiates a command and coordinating level with computed discrete-time map-based (DTM neuronal networks and the central pattern generators with analogue VLSI (Very Large Scale Integration electronic neuron (aVLSI networks. DTM networks are realised using neurons based on a 1-D or 2-D Map with two additional parameters that define silent, spiking and bursting regimes. Electronic neurons (ENs based on Hindmarsh–Rose (HR dynamics can be instantiated in analogue VLSI and exhibit similar behaviour to those based on discrete components. We have constructed locomotor central pattern generators (CPGs with aVLSI networks that can be modulated to select different behaviours on the basis of selective command input. The two technologies can be fused by interfacing the signals from the DTM circuits directly to the aVLSI CPGs. Using DTMs, we have been able to simulate complex sensory fusion for rheotaxic behaviour based on both hydrodynamic and optical flow senses. We will illustrate aspects of controllers for ambulatory biomimetic robots. These studies indicate that it is feasible to fabricate an electronic nervous system controller integrating both aVLSI CPGs and layered DTM exteroceptive reflexes.

  19. Status and Future Developments in Large Accelerator Control Systems

    International Nuclear Information System (INIS)

    Karen S. White

    2006-01-01

    Over the years, accelerator control systems have evolved from small hardwired systems to complex computer controlled systems with many types of graphical user interfaces and electronic data processing. Today's control systems often include multiple software layers, hundreds of distributed processors, and hundreds of thousands of lines of code. While it is clear that the next generation of accelerators will require much bigger control systems, they will also need better systems. Advances in technology will be needed to ensure the network bandwidth and CPU power can provide reasonable update rates and support the requisite timing systems. Beyond the scaling problem, next generation systems face additional challenges due to growing cyber security threats and the likelihood that some degree of remote development and operation will be required. With a large number of components, the need for high reliability increases and commercial solutions can play a key role towards this goal. Future control systems will operate more complex machines and need to present a well integrated, interoperable set of tools with a high degree of automation. Consistency of data presentation and exception handling will contribute to efficient operations. From the development perspective, engineers will need to provide integrated data management in the beginning of the project and build adaptive software components around a central data repository. This will make the system maintainable and ensure consistency throughout the inevitable changes during the machine lifetime. Additionally, such a large project will require professional project management and disciplined use of well-defined engineering processes. Distributed project teams will make the use of standards, formal requirements and design and configuration control vital. Success in building the control system of the future may hinge on how well we integrate commercial components and learn from best practices used in other industries

  20. Phenylketonuria: central nervous system and microbiome interaction

    Directory of Open Access Journals (Sweden)

    Demian Arturo Herrera Morban

    2017-06-01

    Full Text Available Phenylketonuria (PKU is an autosomal recessive inborn error of metabolism characterized by increased phenylalanine (Phe levels causing an inadequate neurodevelopment; the treatment of PKU is a Phe-restricting diet, and as such it can modulate the intestinal microbiome of the individual, generating central nervous system secondary disturbances that, added to the baseline disturbance, can influence the outcome of the disease.