WorldWideScience

Sample records for center target system

  1. LANSCE (Los Alamos Neutron Scattering Center) target system performance

    International Nuclear Information System (INIS)

    Russell, G.J.; Gilmore, J.S.; Robinson, H.; Legate, G.L.; Bridge, A.; Sanchez, R.J.; Brewton, R.J.; Woods, R.; Hughes, H.G. III

    1989-01-01

    The authors measured neutron beam fluxes at LANSCE using gold foil activation techniques. They did an extensive computer simulation of the as-built LANSCE Target/Moderator/Reflector/Shield geometry. They used this mockup in a Monte Carlo calculation to predict LANSCE neutronic performance for comparison with measured results. For neutron beam fluxes at 1 eV, the ratio of measured data to calculated varies from ∼0.6-0.9. The computed 1 eV neutron leakage at the moderator surface is 3.9 x 10 10 n/eV-sr-s-μA for LANSCE high-intensity water moderators. The corresponding values for the LANSCE high-resolution water moderator and the liquid hydrogen moderator are 3.3 and 2.9 x 10 10 , respectively. LANSCE predicted moderator intensities (per proton) for a tungsten target are essentially the same as ISIS predicted moderator intensities for a depleted uranium target. The calculated LANSCE steady state unperturbed thermal (E 13 n/cm 2 -s. The unique LANSCE split-target/flux-trap-moderator system is performing exceedingly well. The system has operated without a target or moderator change for over three years at nominal proton currents of 25 μA of 800-MeV protons. 17 refs., 8 figs., 3 tabs

  2. The LANSCE (Los Alamos Neutron Scattering Center) target data collection system

    International Nuclear Information System (INIS)

    Kernodle, A.K.

    1989-01-01

    The Los Alamos Neutron Scattering Center (LANSCE) Target Data Collection System is the result of an effort to provide a base of information from which to draw conclusions on the performance and operational condition of the overall LANSCE target system. During the conceptualization of the system, several goals were defined. A survey was made of both custom-made and off-the-shelf hardware and software that were capable of meeting these goals. The first stage of the system was successfully implemented for the LANSCE run cycle 52. From the operational experience gained thus far, it appears that the LANSCE Target Data Collection System will meet all of the previously defined requirements

  3. NIF pointing and centering systems and target alignment using a 351 nm laser source

    International Nuclear Information System (INIS)

    Boege, S.J.; Bliss, E.S.; Chocol, C.J.; Holdener, F.R.; Miller, J.L.; Toeppen, J.S.; Vann, C.S.; Zacharias, R.A.

    1996-10-01

    The operational requirements of the National Ignition Facility (NIF) place tight constraints upon its alignment system. In general, the alignment system must establish and maintain the correct relationships between beam position, beam angle, laser component clear apertures, and the target. At the target, this includes adjustment of beam focus to obtain the correct spot size. This must be accomplished for all beamlines in a time consistent with planned shot rates and yet, in the front end and main laser, beam control functions cannot be initiated until the amplifiers have sufficiently cooled so as to minimize dynamic thermal distortions during and after alignment and wavefront optimization. The scope of the task dictates an automated system that implements parallel processes. We describe reticle choices and other alignment references, insertion of alignment beams, principles of operation of the Chamber Center Reference System 2048 and Target Alignment Sensor, and the anticipated alignment sequence that will occur between shots

  4. System design and as-built MCNP model comparison for the Lujan Center target moderator reflector system

    International Nuclear Information System (INIS)

    Muhrer, G.; Ferguson, P.D.; Russell, G.J.; Pitcher, E.J.

    2000-01-01

    During the design of the Manuel Lujan, Jr., Neutron Scattering Center target, a simplified Monte Carlo model was used to estimate target system performance and to aid engineers as decisions were made regarding the construction of the target system. Although the simplified model ideally would perfectly reflect the as-built system performance, assumptions were made in the model during the design process that may result in deviations between the model predictions and the as-built system performance. Now that the Lujan Center target system has been completed, a more detailed, as-built, model of the target system has been completed. The purpose of this work is to investigate differences between the predicted target system performance of the simplified model and the as-built model from the standpoint of time-averaged moderator brightness. Calculated discrepancies between the two models have been isolated to a few key issues. Figure 1 shows MCNP geometric plots of the simplified and as-built models. Major differences between these two models include details in the moderator designs (plena) and piping, full versus partial moderator canisters (only in the direction of the extracted neutron beam for the simplified model), and reflector details including cooling pipes and engineering tolerance gaps. In addition, Fig. 1 demonstrates that the detailed model includes shielding and additional material beyond that which was modeled by the original simplified model

  5. Kansas Water Quality Action Targeting System (KATS)

    Data.gov (United States)

    Kansas Data Access and Support Center — This system is a revision of the original KATS system developed in 1990 as a tool to aid resource managers target Kansas valuable and vulnerable water resources for...

  6. Spallation source neutron target systems

    International Nuclear Information System (INIS)

    Russell, G.; Brown, R.; Collier, M.; Donahue, J.

    1996-01-01

    This is the final report for a two-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The project sought to design a next-generation spallation source neutron target system for the Manuel Lujan, Jr., Neutron Scattering Center (LANSCE) at Los Alamos. It has been recognized for some time that new advanced neutron sources are needed in the US if the country is to maintain a competitive position in several important scientific and technological areas. A recent DOE panel concluded that the proposed Advanced Neutron Source (a nuclear reactor at Oak Ridge National Laboratory) and a high-power pulsed spallation source are both needed in the near future. One of the most technically challenging designs for a spallation source is the target station itself and, more specifically, the target-moderator-reflector arrangement. Los Alamos has demonstrated capabilities in designing, building, and operating high-power spallation-neutron-source target stations. Most of the new design ideas proposed worldwide for target system design for the next generation pulsed spallation source have either been conceived and implemented at LANSCE or proposed by LANSCE target system designers. These concepts include split targets, flux-trap moderators, back scattering and composite moderators, and composite reflectors

  7. Targeting the environmental assessment of veterinary drugs with the multi-species-soil system (MS{center_dot}3) agricultural soil microcosms: the ivermectin case study

    Energy Technology Data Exchange (ETDEWEB)

    Carbonell-Martin, G.; Pro-Gonzalez, J.; Aragones-Grunert, P.; Babib-Vich, M. M.; Fernandez-Rorija, C.; Tarazona-Lafarga, J. V.

    2011-07-01

    The environmental risk assessment of the veterinary pharmaceutical ivermectin is receiving significant attention. This paper assesses the capacity of the MS{center_dot}3 soil microcosm as a tool for targeting the environmental impact assessment of veterinary drugs, using ivermectin as model. Two screening MS{center_dot}3 were performed using different European soils; one with a soil collected in an agricultural station near to Madrid, Spain and a second with a soil collected in a farm area close to York, UK. Soils were fortified with ivermectin at the following ranges: 0.01-10 mg kg{sup -}1 and 0.1-100 mg kg{sup -}1 in the Madrid and York studies, respectively. The effects on earthworms, plants and soil microorganisms were assessed in the Madrid soil. Toxicity tests on aquatic organisms (algae, cladocerans and in vitro fish cell line RTLW1) were also conducted with the leachates. No effects were observed in earthworms and plants at any tested concentration; reduction in the respiration rate (< 5%) of soil microorganisms was detected. Earthworm/soil bioconcentration factors decreased with the increase in soil concentrations and were higher for the York soil. Effects on daphnids were observed in tested leachates; based on measured levels of ivermectin in the leachates an EC50 of about 0.5{mu}gL{sup -}1 can be estimated. Comparisons based on toxicity data and equilibrium partitioning confirmed that the main risk is expected to be related to the high sensitivity of cladocerans. The results confirm that MS{center_dot}3 systems are cost-effective tools for assessing the impact of veterinary pharmaceuticals when applied to agricultural land, as previously demonstrated for antimicrobials. (Author) 39 refs.

  8. New evaporator station for the center for accelerator target science

    Science.gov (United States)

    Greene, John P.; Labib, Mina

    2018-05-01

    As part of an equipment grant provided by DOE-NP for the Center for Accelerator Target Science (CATS) initiative, the procurement of a new, electron beam, high-vacuum deposition system was identified as a priority to insure reliable and continued availability of high-purity targets. The apparatus is designed to contain TWO electron beam guns; a standard 4-pocket 270° geometry source as well as an electron bombardment source. The acquisition of this new system allows for the replacement of TWO outdated and aging vacuum evaporators. Also included is an additional thermal boat source, enhancing our capability within this deposition unit. Recommended specifications for this system included an automated, high-vacuum pumping station, a deposition chamber with a rotating and heated substrate holder for uniform coating capabilities and incorporating computer-controlled state-of-the-art thin film technologies. Design specifications, enhanced capabilities and the necessary mechanical modifications for our target work are discussed.

  9. LANSCE target system performance

    International Nuclear Information System (INIS)

    Russell, G.J.; Gilmore, J.S.; Robinson, H.; Legate, G.L.; Bridge, A.; Sanchez, R.J.; Brewton, R.J.; Woods, R.; Hughes, H.G. III

    1989-01-01

    We measured neutron beam fluxes at LANSCE using gold foil activation techniques. We did an extensive computer simulation of the as-built LANSCE Target/Moderator/Reflector/Shield geometry. We used this mockup in a Monte Carlo calculation to predict LANSCE neutronic performance for comparison with measured results. For neutron beam fluxes at 1 eV, the ratio of measured data to calculated varies from ∼0.6-0.9. The computed 1 eV neutron leakage at the moderator surface is 3.9 x 10 10 n/eV-sr-s-μA for LANSCE high-intensity water moderators. The corresponding values for the LANSCE high-resolution water moderator and the liquid hydrogen moderator are 3.3 and 2.9 x 10 10 , respectively. LANSCE predicted moderator intensities (per proton) for a tungsten target are essentially the same as ISIS predicted moderator intensities for a depleted uranium target. The calculated LANSCE steady state unperturbed thermal (E 13 n/cm 2 -s. The unique LANSCE split-target/flux-trap-moderator system is performing exceedingly well. The system has operated without a target or moderator change for over three years at nominal proton currents of ∼25 μA of 800-MeV protons. (author)

  10. Nova target diagnostics control system

    International Nuclear Information System (INIS)

    Severyn, J.R.

    1985-01-01

    During the past year the Nova target diagnostics control system was finished and put in service. The diagnostics loft constructed to the north of the target room provides the environmental conditions required to collect reliable target diagnostic data. These improvements include equipment cooling and isolation of the power source with strict control of instrumentation grounds to eliminate data corruption due to electromagnetic pulses from the laser power-conditioning system or from target implosion effects

  11. Target marketing for the hospital-based wellness center.

    Science.gov (United States)

    Cangelosi, J D

    1997-01-01

    The American population is aging, medical technology is advancing, and life expectancies are on the rise. At the same time hospitals are looking for additional sources of income due to the pressures of government regulations and managed care. One of the options for hospitals looking for additional sources of income is the hospital-based but free-standing comprehensive wellness and fitness center. Such centers go beyond the facilities, programs and services offered by traditional health and fitness centers. In addition to physical fitness programs, hospital-based wellness centers offer programs in CPR, nutrition, weight control and many other programs of interest to an aging but active American populace. This research documents the hospital industry, wellness industry and the prospects of success or failure for he hospital attempting such a venture. The focus of the research is the experience of a particular hospital with regard to the programs, facilities and services deemed most important by its target market.

  12. High precision target center determination from a point cloud

    Directory of Open Access Journals (Sweden)

    K. Kregar

    2013-10-01

    Full Text Available Many applications of terrestrial laser scanners (TLS require the determination of a specific point from a point cloud. In this paper procedure of high precision planar target center acquisition from point cloud is presented. The process is based on an image matching algorithm but before we can deal with raster image to fit a target on it, we need to properly determine the best fitting plane and project points on it. The main emphasis of this paper is in the precision estimation and propagation through the whole procedure which allows us to obtain precision assessment of final results (target center coordinates. Theoretic precision estimations – obtained through the procedure were rather high so we compared them with the empiric precision estimations obtained as standard deviations of results of 60 independently scanned targets. An χ2-test confirmed that theoretic precisions are overestimated. The problem most probably lies in the overestimated precisions of the plane parameters due to vast redundancy of points. However, empirical precisions also confirmed that the proposed procedure can ensure a submillimeter precision level. The algorithm can automatically detect grossly erroneous results to some extent. It can operate when the incidence angles of a laser beam are as high as 80°, which is desirable property if one is going to use planar targets as tie points in scan registration. The proposed algorithm will also contribute to improve TLS calibration procedures.

  13. Learning System Center App Controller

    CERN Document Server

    Naeem, Nasir

    2015-01-01

    This book is intended for IT professionals working with Hyper-V, Azure cloud, VMM, and private cloud technologies who are looking for a quick way to get up and running with System Center 2012 R2 App Controller. To get the most out of this book, you should be familiar with Microsoft Hyper-V technology. Knowledge of Virtual Machine Manager is helpful but not mandatory.

  14. Development of targeted radiotherapy systems

    International Nuclear Information System (INIS)

    Ferro, Guillermina; Villarreal, Jose E.; Garcia, Laura; Tendilla, Jose I.; Paredes, Lydia; Murphy, Consuelo A.; Pedraza, Martha

    2001-01-01

    Conventional or external beam radiotherapy, has been a viable alternative for cancer treatment. Although this technique is effective, its use is limited if the patient has multiple malignant lesions (metastases). An alternative approach is based on the design of radiopharmaceuticals that, to be administered in the patient, are directed specifically toward the target cell producing a selective radiation delivery. This treatment is known as targeted radiotherapy. We have summarized and discussed some results related to our investigations on the development of targeted radiotherapy systems, including aspects of internal dosimetry

  15. Target raster system at CEBAF

    International Nuclear Information System (INIS)

    Yan, C.; Adderley, P.; Carlini, R.; Cuevas, C.; Vulcan, W.; Wines, R.

    1995-01-01

    A fast raster (FR) system consisting of two Litz cable air-core magnets (x, y) has been installed and tested in the Hall C beam line tunnel, 21 m from the cryogenic target. The system provides a maximum deflection of 0.06 mrad at a frequency range of 15-45 kHz for a 6 GeV electron beam. The FR magnets are driven by a MOSFET bipolar switching power source with a triangle current waveform, the peak-to-peak current is 40 A. (orig.)

  16. Records Center Program Billing System

    Data.gov (United States)

    National Archives and Records Administration — RCPBS supports the Records center programs (RCP) in producing invoices for the storage (NARS-5) and servicing of National Archives and Records Administration’s...

  17. ICF target technology at the Russian Federal Nuclear Center

    International Nuclear Information System (INIS)

    Veselov, A.V.; Drozhin, V.S.; Druzhinin, A.A.; Izgorodin, V.M.; Iiyushechkin, B.N.; Kirillov, G.A.; Komleva, G.V.; Korochkin, A.M.; Medvedev, E.F.; Nikolaev, G.P.; Pikulin, I.V.; Pinegin, A.V.; Punin, V.T.; Romaev, V.N.; Sumatokhin, V.L.; Tarasova, N.N.; Tachaev, G.V.; Cherkesova, I.N.

    1995-01-01

    The main effort of the ICF target fabrication group is support of the experiments performed on the 'ISKRA-4' and 'ISKRA-5' laser systems. The main types of targets used in these experiments are direct drive, inverted corona, and indirect drive. For production of direct drive targets, manufacturing techniques have been developed for both hollow glass and polystyrene microspheres. Hollow glass microspheres are fabricated by free-fall of liquid glass drops or dry gel in a 4 meter vertical kiln. These methods allow us to manufacture glass microspheres with diameters from 50 μm to 1 mm, wall thicknesses from 0.5 to 10 μm, and aspect ratios (radius/ wall) from 20 to 500. The microspheres have a thickness inhomogeneity less than 5% and non-sphericity less than 1%. Polystyrene microspheres are fabricated from polystyrene particles with a blowing agent in a similar vertical kiln. Polystyrene microspheres are fabricated with diameter up to 800 μm and wall thicknesses from 1 to 10 μm. 15 refs., 8 figs

  18. Cortical Activation during Landmark-Centered vs. Gaze-Centered Memory of Saccade Targets in the Human: An FMRI Study

    Directory of Open Access Journals (Sweden)

    Ying Chen

    2017-06-01

    Full Text Available A remembered saccade target could be encoded in egocentric coordinates such as gaze-centered, or relative to some external allocentric landmark that is independent of the target or gaze (landmark-centered. In comparison to egocentric mechanisms, very little is known about such a landmark-centered representation. Here, we used an event-related fMRI design to identify brain areas supporting these two types of spatial coding (i.e., landmark-centered vs. gaze-centered for target memory during the Delay phase where only target location, not saccade direction, was specified. The paradigm included three tasks with identical display of visual stimuli but different auditory instructions: Landmark Saccade (remember target location relative to a visual landmark, independent of gaze, Control Saccade (remember original target location relative to gaze fixation, independent of the landmark, and a non-spatial control, Color Report (report target color. During the Delay phase, the Control and Landmark Saccade tasks activated overlapping areas in posterior parietal cortex (PPC and frontal cortex as compared to the color control, but with higher activation in PPC for target coding in the Control Saccade task and higher activation in temporal and occipital cortex for target coding in Landmark Saccade task. Gaze-centered directional selectivity was observed in superior occipital gyrus and inferior occipital gyrus, whereas landmark-centered directional selectivity was observed in precuneus and midposterior intraparietal sulcus. During the Response phase after saccade direction was specified, the parietofrontal network in the left hemisphere showed higher activation for rightward than leftward saccades. Our results suggest that cortical activation for coding saccade target direction relative to a visual landmark differs from gaze-centered directional selectivity for target memory, from the mechanisms for other types of allocentric tasks, and from the directionally

  19. A rotating target wheel system for gammasphere

    International Nuclear Information System (INIS)

    Greene, J. P.

    1999-01-01

    A description is given for a low-mass, rotating target wheel to be used within the Gammasphere target chamber. This system was developed for experiments employing high beam currents in order to extend lifetimes of targets using low-melting point target material. The design is based on a previously successful implementation of rotating target wheels for the Argonne Positron Experiment (APEX) as well as the Fragment Mass Analyser (FMA) at ATLAS (Argonne Tandem Linac Accelerator System). A brief history of these rotating target wheel systems is given as well as a discussion on target preparation and performance

  20. Army Continuing Education System Centers

    Science.gov (United States)

    1979-05-01

    Scheme C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... 6-20 Example Plan–Scheme Coeducation Center for 21,000 Military...Information to supplement construction completion records shall be prepared to instruct the installation on how to gain the most benefit from such...High School Completion Program (HSCP). This gives soldiers a chance to earn a high school diploma or a State-issued high school equivalency certificate

  1. Analytic reducibility of nondegenerate centers: Cherkas systems

    Directory of Open Access Journals (Sweden)

    Jaume Giné

    2016-07-01

    where $P_i(x$ are polynomials of degree $n$, $P_0(0=0$ and $P_0'(0 <0$. Computing the focal values we find the center conditions for such systems for degree $3$, and using modular arithmetics for degree $4$. Finally we do a conjecture about the center conditions for Cherkas polynomial differential systems of degree $n$.

  2. Simulations of effusion from ISOL target/ion source systems

    International Nuclear Information System (INIS)

    Mustapha, B.; Nolen, J.A.

    2004-01-01

    Monte Carlo simulations of the low- and high-conductivity Target/Ion Source systems used at Oak Ridge National Laboratory for effusion measurements are performed. Comparisons with the corresponding experimental data for the different geometries are presented and discussed. Independent checks of the simulation using data for simple geometries and using the conductance approach well known in vacuum technology are performed. A simulation-based comparison between the low- and high-conductivity systems is also presented

  3. Microsoft System Center 2012 Orchestrator cookbook

    CERN Document Server

    Erskine, Samuel

    2013-01-01

    This book is written in a practical, Cookbook style with numerous chapters and recipes focusing on creating runbooks to automate mission critical and everyday administration tasks.System Center 2012 Orchestrator is for administrators who wish to simplify the process of automating systems administration tasks. This book assumes that you have a basic knowledge of Windows Server 2008 Administration, Active Directory, Network Systems, and Microsoft System Center technologies.

  4. Representing Targets of Measurement within Evidence-Centered Design

    Science.gov (United States)

    Ewing, Maureen; Packman, Sheryl; Hamen, Cynthia; Thurber, Allison Clark

    2010-01-01

    In the last few years, the Advanced Placement (AP) Program[R] has used evidence-centered assessment design (ECD) to articulate the knowledge, skills, and abilities to be taught in the course and measured on the summative exam for four science courses, three history courses, and six world language courses; its application to calculus and English…

  5. Progress in ISOL target-ion source systems

    Energy Technology Data Exchange (ETDEWEB)

    Koester, U. [Institut Laue Langevin, 6 Rue Jules Horowitz, F-38042 Grenoble Cedex 9 (France); ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland)], E-mail: koester@ill.fr; Arndt, O. [HGF VISTARS and Institut fuer Kernchemie, Johannes-Gutenberg Universitaet Mainz, D-55128 Mainz (Germany); Bouquerel, E.; Fedoseyev, V.N. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Franberg, H. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Laboratory for Radio- and Environmental Chemistry, Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland); Joinet, A. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Centre d' Etude Spatiale des Rayonnements, 9 Av. du Colonel Roche, F-31028 Toulouse Cedex 4 (France); Jost, C. [HGF VISTARS and Institut fuer Kernchemie, Johannes-Gutenberg Universitaet Mainz, D-55128 Mainz (Germany); Kerkines, I.S.K. [Laboratory of Physical Chemistry, National and Kapodistrian University of Athens, Department of Chemistry, Zografou 157 71, GR (Greece); Cherry L. Emerson Center for Scientific Computation and Department of Chemistry, Emory University, Atlanta, GA 30322 (United States); Kirchner, R. [Gesellschaft fuer Schwerionenforschung, Planckstr. 1, D-64291 Darmstadt (Germany)

    2008-10-15

    The heart of every ISOL (isotope separation on-line) facility is its target and ion source system. Its efficiency, selectivity and rapidity is decisive for the production of intense and pure ion beams of short-lived isotopes. Recent progress in ISOL target and ion source technology is discussed at the examples of radioactive ion beams of exotic zinc and tin isotopes that were purified by isothermal chromatography and molecular sideband separation respectively. An outlook is given to which other elements these purification methods are applicable.

  6. Progress in ISOL target-ion source systems

    International Nuclear Information System (INIS)

    Koester, U.; Arndt, O.; Bouquerel, E.; Fedoseyev, V.N.; Franberg, H.; Joinet, A.; Jost, C.; Kerkines, I.S.K.; Kirchner, R.

    2008-01-01

    The heart of every ISOL (isotope separation on-line) facility is its target and ion source system. Its efficiency, selectivity and rapidity is decisive for the production of intense and pure ion beams of short-lived isotopes. Recent progress in ISOL target and ion source technology is discussed at the examples of radioactive ion beams of exotic zinc and tin isotopes that were purified by isothermal chromatography and molecular sideband separation respectively. An outlook is given to which other elements these purification methods are applicable.

  7. A new transfer system for solid targets

    Science.gov (United States)

    Klug, J.; Buckley, K. R.; Zeisler, S. K.; Dodd, M.; Tsao, P.; Hoehr, C.; Economou, C.; Corsaut, J.; Appiah, J. P.; Kovacs, M. S.; Valliant, J. F.; Benard, F.; Ruth, T. J.; Schaffer, P.

    2012-12-01

    As part of a collaborative research project funded by Natural Resources Canada, TRIUMF has designed and manufactured solid target and solid target processing systems for the production of technetium-99m using small medical cyclotrons. The system described herein is capable of transporting the target from a hotcell, where the target is loaded and processed, to the cyclotron and back again. The versatility of the transfer system was demonstrated through the successful installation and operation on the ACSI TR 19 at the BC Cancer Agency, the GE PETtrace cyclotrons at Lawson Health Research (LHRI) and the Centre for Probe Development and Commercialization (CDPC).

  8. Targeting the endocannabinoid system : future therapeutic strategies

    NARCIS (Netherlands)

    Aizpurua-Olaizola, Oier; Elezgarai, Izaskun; Rico-Barrio, Irantzu; Zarandona, Iratxe; Etxebarria, Nestor; Usobiaga, Aresatz

    2017-01-01

    The endocannabinoid system (ECS) is involved in many physiological regulation pathways in the human body, which makes this system the target of many drugs and therapies. In this review, we highlight the latest studies regarding the role of the ECS and the drugs that target it, with a particular

  9. I sup(123) target transfer system

    International Nuclear Information System (INIS)

    Almeida, G.L. de; Rautenberg, F.A.

    1986-01-01

    The construction of target transfer system using a robot into hot cell of IEN cyclotron (Brazilian-CNEN) for sup(123)I production is presented. The system operation is described, and the advantages are shown. (M.C.K.)

  10. Lujan Center Mark-IV Target Neutronics Design Internal Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Lisowski, Paul W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gallmeier, Franz [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Guber, Klaus [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2018-02-26

    The 1L Target Moderator Reflector System (TMRS) at the Lujan Center will need to be replaced before the CY 2020 operating cycle. A Physics Division design team investigated options for improving the overall target performance for nuclear science research with minimal reduction in performance for materials science. This review concluded that devoting an optimized arrangement of the Lujan TMRS upper tier to nuclear science and using the lower tier for materials science can achieve those goals. This would open the opportunity for enhanced nuclear science research in an important neutron energy range for NNSA. There will be no other facility in the US that will compete in the keV energy range provided flight paths and instrumentation are developed to take advantage of the neutron flux and resolution.

  11. Target plane imaging system for the Nova laser

    International Nuclear Information System (INIS)

    Swift, C.D.; Bliss, E.S.; Jones, W.A.; Reeves, R.J.; Seppala, L.G.; Shelton, R.T.; VanArsdall, P.J.

    1985-01-01

    The Nova laser, in operation since December 1984, is capable of irradiating targets with light at 1.05 μm, 0.53 μm, and 0.35 μm. Correct alignment of these harmonic beams uses a system called a target plane imager (TPI). It is a large microscope (four meters long, weighing one thousand kilograms) that relays images from the target chamber center to a video optics module located on the outside of the chamber. Several modes of operation are possible including: near-field viewing and far-field viewing at three magnifications and three wavelengths. In addition, the entire instrument can be scanned in X,Y,Z to examine various planes near chamber center. Performance of this system and its computer controls will be described

  12. Data Center Equipment Location and Monitoring System

    DEFF Research Database (Denmark)

    2013-01-01

    Abstract: Data center equipment location systems include hardware and software to provide information on the location, monitoring, and security of servers and other equipment in equipment racks. The systems provide a wired alternative to the wireless RFID tag system by using electronic ID tags...... connected to each piece of equipment, each electronic ID tag connected directly by wires to an equipment rack controller on the equipment rack. The equipment rack controllers link to a central control computer that provides an operator ...

  13. Resonances in the two centers Coulomb system

    Energy Technology Data Exchange (ETDEWEB)

    Seri, Marcello

    2012-09-14

    In this work we investigate the existence of resonances for two-centers Coulomb systems with arbitrary charges in two and three dimensions, defining them in terms of generalized complex eigenvalues of a non-selfadjoint deformation of the two-center Schroedinger operator. After giving a description of the bifurcation of the classical system for positive energies, we construct the resolvent kernel of the operators and we prove that they can be extended analytically to the second Riemann sheet. The resonances are then defined and studied with numerical methods and perturbation theory.

  14. Resonances in the two centers Coulomb system

    International Nuclear Information System (INIS)

    Seri, Marcello

    2012-01-01

    In this work we investigate the existence of resonances for two-centers Coulomb systems with arbitrary charges in two and three dimensions, defining them in terms of generalized complex eigenvalues of a non-selfadjoint deformation of the two-center Schroedinger operator. After giving a description of the bifurcation of the classical system for positive energies, we construct the resolvent kernel of the operators and we prove that they can be extended analytically to the second Riemann sheet. The resonances are then defined and studied with numerical methods and perturbation theory.

  15. Target system neutronics study for NXGENS

    International Nuclear Information System (INIS)

    Willis, C.; Muhrer, G.

    2007-01-01

    The Materials Test Station (MTS) [E. Pitcher, G. Muhrer, H. Trellue, Neutronics Assessment of the LANSCE Materials Test Station as an Irradiation Facility for the JIMO Space Reactor, LA-CP-04-0903.], a spallation target station, planned for construction at the Los Alamos Neutron Science Center (LANSCE), will provide the opportunity to test the prototype of a long-pulse spallation source neutron scattering instrument (NXGENS). In this paper, we present the target-moderator neutronics optimization study that was performed in support of NXGENS

  16. Magnetic confinement system using charged ammonia targets

    International Nuclear Information System (INIS)

    Porter, G.D.; Bogdanoff, A.

    1979-01-01

    A system is described for guiding charged laser targets to a predetermined focal spot of a laser along generally arbitrary, and especially horizontal, directions which comprises a series of electrostatic sensors which provide inputs to a computer for real time calculation of position, velocity, and direction of the target along an initial injection trajectory

  17. Shiva and Argus target diagnostics vacuum systems

    International Nuclear Information System (INIS)

    Glaros, S.S.; Mayo, S.E.; Campbell, D.; Holeman, D.

    1978-09-01

    The normal operation of LLL's Argus and Shiva laser irradiation facilities demand a main vacuum system for the target chamber and a separate local vacuum system for each of the larger appendage dianostics. This paper will describe the Argus and Shiva main vacuum systems, their respective auxiliary vacuum systems and the individual diagnostics with their respective special vacuum requirements and subsequent vacuum systems. Our latest approach to automatic computer-controlled vacuum systems will be presented

  18. The Regional Test Center Data Transfer System

    Energy Technology Data Exchange (ETDEWEB)

    Riley, Daniel M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Photovoltaic and Distributed Systems Dept.; Stein, Joshua S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Photovoltaic and Distributed Systems Dept.

    2016-09-01

    The Regional Test Centers are a group of several sites around the US for testing photovoltaic systems and components related to photovoltaic systems. The RTCs are managed by Sandia National Laboratories. The data collected by the RTCs must be transmitted to Sandia for storage, analysis, and reporting. This document describes the methods that transfer the data between remote sites and Sandia as well as data movement within Sandia’s network. The methods described are in force as of September, 2016.

  19. A windowless frozen hydrogen target system

    International Nuclear Information System (INIS)

    Knowles, P.E.; Beer, G.A.; Beveridge, J.L.

    1995-06-01

    A cryogenic target system has been constructed in which gaseous mixtures of all three hydrogen isotopes have been frozen onto a thin, 65 mm diameter gold foil. The foil is cooled to 3 K while inside a 70 K radiation shield, all of which is mounted in a vacuum system maintained at 10 -9 torr. Stable multi-layer hydrogen targets of known uniformity and thickness have been maintained for required measurement times of up to several days. To date, hundreds of targets have been successfully used in muon-catalyzed fusion experiments at TRIUMF. (author). 12 refs., 6 figs

  20. Targeting engineering synchronization in chaotic systems

    Science.gov (United States)

    Bhowmick, Sourav K.; Ghosh, Dibakar

    2016-07-01

    A method of targeting engineering synchronization states in two identical and mismatch chaotic systems is explained in detail. The method is proposed using linear feedback controller coupling for engineering synchronization such as mixed synchronization, linear and nonlinear generalized synchronization and targeting fixed point. The general form of coupling design to target any desire synchronization state under unidirectional coupling with the help of Lyapunov function stability theory is derived analytically. A scaling factor is introduced in the coupling definition to smooth control without any loss of synchrony. Numerical results are done on two mismatch Lorenz systems and two identical Sprott oscillators.

  1. NASA Langley Research Center tethered balloon systems

    Science.gov (United States)

    Owens, Thomas L.; Storey, Richard W.; Youngbluth, Otto

    1987-01-01

    The NASA Langley Research Center tethered balloon system operations are covered in this report for the period of 1979 through 1983. Meteorological data, ozone concentrations, and other data were obtained from in situ measurements. The large tethered balloon had a lifting capability of 30 kilograms to 2500 meters. The report includes descriptions of the various components of the balloon systems such as the balloons, the sensors, the electronics, and the hardware. Several photographs of the system are included as well as a list of projects including the types of data gathered.

  2. Digital optical computers at the optoelectronic computing systems center

    Science.gov (United States)

    Jordan, Harry F.

    1991-01-01

    The Digital Optical Computing Program within the National Science Foundation Engineering Research Center for Opto-electronic Computing Systems has as its specific goal research on optical computing architectures suitable for use at the highest possible speeds. The program can be targeted toward exploiting the time domain because other programs in the Center are pursuing research on parallel optical systems, exploiting optical interconnection and optical devices and materials. Using a general purpose computing architecture as the focus, we are developing design techniques, tools and architecture for operation at the speed of light limit. Experimental work is being done with the somewhat low speed components currently available but with architectures which will scale up in speed as faster devices are developed. The design algorithms and tools developed for a general purpose, stored program computer are being applied to other systems such as optimally controlled optical communication networks.

  3. Joint Logistics Systems Center Reporting of Systems Development Costs

    National Research Council Canada - National Science Library

    1998-01-01

    ...." The Joint Logistics Systems Center (JLSC) was organized in FY 1992 to accomplish Corporate Information Management goals for the depot maintenance and supply management business areas of the DoD Working Capital Funds...

  4. Target system materials and engineering problems

    International Nuclear Information System (INIS)

    Fischer, W.E.

    1989-01-01

    This paper discusses the common problems of target design. As a model for the discussion, the author considers a spallation source which is fed by a high power proton beam of the order of one megawatt. The materials used for the target station and particularly for the spallation target itself depend on whether the source is built for pulsed, modulated or continuous operation. The difference of materials used is mainly determined by the neutronics considerations. Depending on the choice of materials for the target systems, the characters of material problems met, are of somewhat different nature. It is recognized that for each target version quite specific difficulties have to be overcome. On the other hand, there is a whole set of problems which is common to all target versions. These are: heat load in region of proton beam interactions; thermal stress and cycling; and radiation damage. It is shown that solutions to the whole package of problems up to a beam power of 0 (1MW) have been found. The whole effort concentrates onto the region of the first few centimeters of beam penetration. Two solutions have been proposed: (1) Keep the power of proton beam limited and produce neutrons elsewhere in the target. and (2) Dilute the power by moving mechanically the target and the window. 8 refs., 11 figs

  5. Mastering System Center 2012 Configuration Manager

    CERN Document Server

    Rachui, Steve; Martinez, Santos; Daalmans, Peter

    2012-01-01

    Expert coverage of Microsoft's highly anticipated network software deployment tool The latest version of System Center Configuration Manager (SCCM) is a dramatic update of its predecessor Configuration Manager 2007, and this book offers intermediate-to-advanced coverage of how the new SCCM boasts a simplified hierarchy, role-based security, a new console, flexible application deployment, and mobile management. You'll explore planning and installation, migrating from SCCM 2007, deploying software and operating systems, security, monitoring and troubleshooting, and automating and customizing SCC

  6. Optical multicast system for data center networks.

    Science.gov (United States)

    Samadi, Payman; Gupta, Varun; Xu, Junjie; Wang, Howard; Zussman, Gil; Bergman, Keren

    2015-08-24

    We present the design and experimental evaluation of an Optical Multicast System for Data Center Networks, a hardware-software system architecture that uniquely integrates passive optical splitters in a hybrid network architecture for faster and simpler delivery of multicast traffic flows. An application-driven control plane manages the integrated optical and electronic switched traffic routing in the data plane layer. The control plane includes a resource allocation algorithm to optimally assign optical splitters to the flows. The hardware architecture is built on a hybrid network with both Electronic Packet Switching (EPS) and Optical Circuit Switching (OCS) networks to aggregate Top-of-Rack switches. The OCS is also the connectivity substrate of splitters to the optical network. The optical multicast system implementation requires only commodity optical components. We built a prototype and developed a simulation environment to evaluate the performance of the system for bulk multicasting. Experimental and numerical results show simultaneous delivery of multicast flows to all receivers with steady throughput. Compared to IP multicast that is the electronic counterpart, optical multicast performs with less protocol complexity and reduced energy consumption. Compared to peer-to-peer multicast methods, it achieves at minimum an order of magnitude higher throughput for flows under 250 MB with significantly less connection overheads. Furthermore, for delivering 20 TB of data containing only 15% multicast flows, it reduces the total delivery energy consumption by 50% and improves latency by 55% compared to a data center with a sole non-blocking EPS network.

  7. Data center equipment location and monitoring system

    DEFF Research Database (Denmark)

    2011-01-01

    A data center equipment location system includes both hardware and software to provide for location, monitoring, security and identification of servers and other equipment in equipment racks. The system provides a wired alternative to the wireless RFID tag system by using electronic ID tags...... connected to each piece of equipment, each electronic ID tag connected directly by wires to a equipment rack controller on the equipment rack. The equipment rack controllers then link over a local area network to a central control computer. The central control computer provides an operator interface......, and runs a software application program that communicates with the equipment rack controllers. The software application program of the central control computer stores IDs of the equipment rack controllers and each of its connected electronic ID tags in a database.; The software application program...

  8. Targeting the Thioredoxin System for Cancer Therapy.

    Science.gov (United States)

    Zhang, Junmin; Li, Xinming; Han, Xiao; Liu, Ruijuan; Fang, Jianguo

    2017-09-01

    Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In recent years TrxR/Trx have been increasingly recognized as an important modulator of tumor development, and hence targeting TrxR/Trx is a promising strategy for cancer treatment. In this review we first discuss the structural details of TrxR, the functions of the Trx system, and the rational of targeting TrxR/Trx for cancer treatment. We also highlight small-molecule TrxR/Trx inhibitors that have potential anticancer activity and review their mechanisms of action. Finally, we examine the challenges of developing TrxR/Trx inhibitors as anticancer agents and perspectives for selectively targeting TrxR/Trx. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Recent Advances in Aptamers Targeting Immune System.

    Science.gov (United States)

    Hu, Piao-Ping

    2017-02-01

    The immune system plays important role in protecting the organism by recognizing non-self molecules from pathogen such as bacteria, parasitic worms, and viruses. When the balance of the host defense system is disturbed, immunodeficiency, autoimmunity, and inflammation occur. Nucleic acid aptamers are short single-stranded DNA (ssDNA) or RNA ligands that interact with complementary molecules with high specificity and affinity. Aptamers that target the molecules involved in immune system to modulate their function have great potential to be explored as new diagnostic and therapeutic agents for immune disorders. This review summarizes recent advances in the development of aptamers targeting immune system. The selection of aptamers with superior chemical and biological characteristics will facilitate their application in the diagnosis and treatment of immune disorders.

  10. Conceptual design study of IFMIF target system

    International Nuclear Information System (INIS)

    Kato, Y.; Nakamura, H.; Ida, M.; Maekawa, H.; Katsuta, H.; Hua, T.; Cevolani, S.

    1997-01-01

    IFMIF-CDA (International Fusion Materials Irradiation Facility - Conceptual Design Activity) had been carried out during 1995 and 1996, under the auspices of the IEA. The mission of this facility is to provide an accelerator based deuterium-lithium (D-Li) neutron source to test the candidate materials of radiation - resistant and low - activation materials up to about a full lifetime of anticipated use in fusion energy reactors. The neutrons of about 14 MeV are obtained by the stripping reaction of the deuteron of Max. 40 MeV with target lithium. Total deuteron beam current is about 250 mA and beam footprint is 20 cm x 5 cm on the free surface of lithium jet. In this report general characteristics of the target lithium system and the results of thermal and flow analysis for the target lithium jet are described. (author)

  11. A Context Dependent Automatic Target Recognition System

    Science.gov (United States)

    Kim, J. H.; Payton, D. W.; Olin, K. E.; Tseng, D. Y.

    1984-06-01

    This paper describes a new approach to automatic target recognizer (ATR) development utilizing artificial intelligent techniques. The ATR system exploits contextual information in its detection and classification processes to provide a high degree of robustness and adaptability. In the system, knowledge about domain objects and their contextual relationships is encoded in frames, separating it from low level image processing algorithms. This knowledge-based system demonstrates an improvement over the conventional statistical approach through the exploitation of diverse forms of knowledge in its decision-making process.

  12. Grid Integration Science, NREL Power Systems Engineering Center

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-04-25

    This report highlights journal articles published in 2016 by researchers in the Power Systems Engineering Center. NREL's Power Systems Engineering Center published 47 journal and magazine articles in the past year, highlighting recent research in grid modernization.

  13. Preparation of targets using electron gun systems

    International Nuclear Information System (INIS)

    Maier-Komor, P.

    1975-01-01

    Most targets of isotopes with very low vapor pressure can only be fabricated by vacuum deposition using an electron gun system or a heavy ion sputtering system. Heavy ion sputtering is a very new technique with many unsolved problems. Therefore it seems to be easier to work with an electron gun. Different commercially available electron guns, which are all designed for the high evaporation rates used in industry, are examined for their qualification in processing small amounts of material as used in fabrication of isotope targets. Electron backscattering and the associated efficiency of the electron beam power is strongly dependent on the atomic number Z of the evaporant and the incident angle of the electron beam on the surface of the evaporant. This dependence leads also to the undesired effects to the target layers from electrons and ions. Some precautions are necessary against the effects of the electrons and ions, which are formed in the plasma directly over the beam impact point. Beam power and beam density have to be chosen to get a constant evaporation rate and a low enough condensation rate in order not to overheat the target substrates. To evaporate some metals it may be helpful to pulse the electron beam

  14. Remote Sensing/Geographic Information Systems Center

    Data.gov (United States)

    Federal Laboratory Consortium — The RS/GIS Center, located at ERDC's Cold Regions Research and Engineering Laboratory, in Hanover, New Hampshire, is the Corps of Engineers Center of Expertise for...

  15. Center conditions and limit cycles for BiLienard systems

    Directory of Open Access Journals (Sweden)

    Jaume Gine

    2017-03-01

    Full Text Available In this article we study the center problem for polynomial BiLienard systems of degree n. Computing the focal values and using Grobner bases we find the center conditions for such systems for n=6. We also establish a conjecture about the center conditions for polynomial BiLienard systems of arbitrary degree.

  16. Preliminary conceptual design of target system. Pt. 1. System configuration

    Energy Technology Data Exchange (ETDEWEB)

    Hino, Ryutaro; Haga, Katsuhiro; Kaminaga, Masanori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment] [and others

    1997-07-01

    In the 21st century, neutron is expected to play a very important role in the fields of structural biology, nuclear physics, material science if a very high-intensity neutron source will be built because of its superior nature as an probe to investigate material structure and its function. The Japan Atomic Energy Research Institute has launched the Neutron Science Project for construction and utilization of a high-intensity spallation neutron source coupled with a proton accelerator. In the project, a neutron scattering facility is planned to be constructed in an early stage. Development of a 5MW spallation neutron source is one of the most difficult technical challenges in this project. A two-step development plan of the target was established to construct a 5MW-target station In the 1st step, a 1.5MW target will be constructed to develop 5MW target technology. The preliminary conceptual design was conducted to clarify the specifications of the target system of 1.5MW and 5MW including system layout, scale etc. This report describes (1) a design policy, (2) a layout of system consisting of the target, remote-handling devices, bio-shieldings etc., (3) specifications of components and facilities such as cooling systems for target and moderators, beam-port shutter and air conditioning system, (4) overhaul procedures by remote-handling devices, (5) safety assessment, and (6) necessary R and D items derived from the design activity. (author)

  17. A Study on Control System Design Based on ARM Sea Target Search System

    Directory of Open Access Journals (Sweden)

    Lin Xinwei

    2015-01-01

    Full Text Available The infrared detector is used for sea target search, which can assist humans in searching suspicious objects at night and under poor visibility conditions, and improving search efficiency. This paper applies for interrupt and stack technology to solve problems of data losses that may be caused by one-to-many multi-byte protocol communication. Meanwhile, this paper implements hardware and software design of the system based on industrial-grade ARM control chip and uC / OS-II embedded operating system. The control system in the sea target search system is an information exchange and control center of the whole system, which solves the problem of controlling over the shooting angle of the infrared detector in the process of target search. After testing, the control system operates stably and reliably, and realizes rotation and control functions of the pan/tilt platform during automatic search, manual search and track.

  18. Current status of the 124Xe target system development for the high purity 123I production in KCCH

    International Nuclear Information System (INIS)

    Chun, Kwon Soo

    2002-01-01

    This report describes the 124 Xe gaseous target system employed for 123 I production at the Korea Cancer Center Hospital. Currently the control system is manual and will be computerized after the system parameters have been established

  19. Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp3 Centers Enhance Target Selectivity

    Directory of Open Access Journals (Sweden)

    Stefania Monteleone

    2017-08-01

    Full Text Available Dark chemical matter compounds are small molecules that have been recently identified as highly potent and selective hits. For this reason, they constitute a promising class of possible candidates in the process of drug discovery and raise the interest of the scientific community. To this purpose, Wassermann et al. (2015 have described the application of 2D descriptors to characterize dark chemical matter. However, their definition was based on the number of reported positive assays rather than the number of known targets. As there might be multiple assays for one single target, the number of assays does not fully describe target selectivity. Here, we propose an alternative classification of active molecules that is based on the number of known targets. We cluster molecules in four classes: black, gray, and white compounds are active on one, two to four, and more than four targets respectively, whilst inactive compounds are found to be inactive in the considered assays. In this study, black and inactive compounds are found to have not only higher solubility, but also a higher number of chiral centers, sp3 carbon atoms and aliphatic rings. On the contrary, white compounds contain a higher number of double bonds and fused aromatic rings. Therefore, the design of a screening compound library should consider these molecular properties in order to achieve target selectivity or polypharmacology. Furthermore, analysis of four main target classes (GPCRs, kinases, proteases, and ion channels shows that GPCR ligands are more selective than the other classes, as the number of black compounds is higher in this target superfamily. On the other side, ligands that hit kinases, proteases, and ion channels bind to GPCRs more likely than to other target classes. Consequently, depending on the target protein family, appropriate screening libraries can be designed in order to minimize the likelihood of unwanted side effects early in the drug discovery process

  20. Target Selection and Deselection at the Berkeley StructuralGenomics Center

    Energy Technology Data Exchange (ETDEWEB)

    Chandonia, John-Marc; Kim, Sung-Hou; Brenner, Steven E.

    2005-03-22

    At the Berkeley Structural Genomics Center (BSGC), our goalis to obtain a near-complete structural complement of proteins in theminimal organisms Mycoplasma genitalium and M. pneumoniae, two closelyrelated pathogens. Current targets for structure determination have beenselected in six major stages, starting with those predicted to be mosttractable to high throughput study and likely to yield new structuralinformation. We report on the process used to select these proteins, aswell as our target deselection procedure. Target deselection reducesexperimental effort by eliminating targets similar to those recentlysolved by the structural biology community or other centers. We measurethe impact of the 69 structures solved at the BSGC as of July 2004 onstructure prediction coverage of the M. pneumoniae and M. genitaliumproteomes. The number of Mycoplasma proteins for which thefold couldfirst be reliably assigned based on structures solved at the BSGC (24 M.pneumoniae and 21 M. genitalium) is approximately 25 percent of the totalresulting from work at all structural genomics centers and the worldwidestructural biology community (94 M. pneumoniae and 86M. genitalium)during the same period. As the number of structures contributed by theBSGC during that period is less than 1 percent of the total worldwideoutput, the benefits of a focused target selection strategy are apparent.If the structures of all current targets were solved, the percentage ofM. pneumoniae proteins for which folds could be reliably assigned wouldincrease from approximately 57 percent (391 of 687) at present to around80 percent (550 of 687), and the percentage of the proteome that could beaccurately modeled would increase from around 37 percent (254 of 687) toabout 64 percent (438 of 687). In M. genitalium, the percentage of theproteome that could be structurally annotated based on structures of ourremaining targets would rise from 72 percent (348 of 486) to around 76percent (371 of 486), with the

  1. Center for Efficiency in Sustainable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, Martin [Youngstown State Univ., OH (United States)

    2016-01-31

    The main goal of the Center for Efficiency in Sustainable Energy Systems is to produce a methodology that evaluates a variety of energy systems. Task I. Improved Energy Efficiency for Industrial Processes: This task, completed in partnership with area manufacturers, analyzes the operation of complex manufacturing facilities to provide flexibilities that allow them to improve active-mode power efficiency, lower standby-mode power consumption, and use low cost energy resources to control energy costs in meeting their economic incentives; (2) Identify devices for the efficient transformation of instantaneous or continuous power to different devices and sections of industrial plants; and (3) use these manufacturing sites to demonstrate and validate general principles of power management. Task II. Analysis of a solid oxide fuel cell operating on landfill gas: This task consists of: (1) analysis of a typical landfill gas; (2) establishment of a comprehensive design of the fuel cell system (including the SOFC stack and BOP), including durability analysis; (3) development of suitable reforming methods and catalysts that are tailored to the specific SOFC system concept; and (4) SOFC stack fabrication with testing to demonstrate the salient operational characteristics of the stack, including an analysis of the overall energy conversion efficiency of the system. Task III. Demonstration of an urban wind turbine system: This task consists of (1) design and construction of two side-by-side wind turbine systems on the YSU campus, integrated through power control systems with grid power; (2) preliminary testing of aerodynamic control effectors (provided by a small business partner) to demonstrate improved power control, and evaluation of the system performance, including economic estimates of viability in an urban environment; and (3) computational analysis of the wind turbine system as an enabling activity for development of smart rotor blades that contain integrated sensor

  2. Tumour targeting with systemically administered bacteria.

    LENUS (Irish Health Repository)

    Morrissey, David

    2012-01-31

    Challenges for oncology practitioners and researchers include specific treatment and detection of tumours. The ideal anti-cancer therapy would selectively eradicate tumour cells, whilst minimising side effects to normal tissue. Bacteria have emerged as biological gene vectors with natural tumour specificity, capable of homing to tumours and replicating locally to high levels when systemically administered. This property enables targeting of both the primary tumour and secondary metastases. In the case of invasive pathogenic species, this targeting strategy can be used to deliver genes intracellularly for tumour cell expression, while non-invasive species transformed with plasmids suitable for bacterial expression of heterologous genes can secrete therapeutic proteins locally within the tumour environment (cell therapy approach). Many bacterial genera have been demonstrated to localise to and replicate to high levels within tumour tissue when intravenously (IV) administered in rodent models and reporter gene tagging of bacteria has permitted real-time visualisation of this phenomenon. Live imaging of tumour colonising bacteria also presents diagnostic potential for this approach. The nature of tumour selective bacterial colonisation appears to be tumour origin- and bacterial species- independent. While originally a correlation was drawn between anaerobic bacterial colonisation and the hypoxic nature of solid tumours, it is recently becoming apparent that other elements of the unique microenvironment within solid tumours, including aberrant neovasculature and local immune suppression, may be responsible. Here, we consider the pre-clinical data supporting the use of bacteria as a tumour-targeting tool, recent advances in the area, and future work required to develop it into a beneficial clinical tool.

  3. Mercury erosion experiments for spallation target system

    International Nuclear Information System (INIS)

    Kinoshita, Hidetaka; Kaminaga, Masanori; Haga, Katsuhiro; Hino, Ryutaro

    2003-01-01

    The Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK) are promoting a plan to construct the spallation neutron source at the Tokai Research Establishment, JAERI, under the High-Intensity Proton Accelerator Project (J-PARC). A mercury circulation system has been designed so as to supply mercury to the target stably under the rated flow rate of 41 m 3 /hr. Then, it was necessary to confirm a mercury pump performance from the viewpoint of making the mercury circulation system feasible, and more, to investigate erosion rate under the mercury flow as well as an amount of mercury remained on the surface after drain from the viewpoints of mechanical strength relating to the lifetime and remote handling of mercury components. The mercury pump performance was tested under the mercury flow conditions by using an experimental gear pump, which had almost the same structure as a practical mercury pump to be expected in the mercury circulation system, and the erosion rates in a mercury pipeline as well as the amount of mercury remained on the surface were also investigated. The discharged flow rates of the experimental gear pump increased linearly with the rotation speed, so that the gear pump would work as the flow meter. Erosion rates obtained under the mercury velocity less than 1.6 m/s was found to be so small that decrease of pipeline wall thickness would be 390 μm after 30-year operation under the rated mercury velocity of 0.7 m/s. For the amount of remaining mercury on the pipeline, remaining rates of weight and volume were estimated at 50.7 g/m 2 and 3.74 Hg-cm 3 /m 2 , respectively. Applying these remaining rates of weight and volume to the mercury target, the remaining mercury was estimated at about 106.5 g and 7.9 cm 3 . Radioactivity of this remaining mercury volume was found to be three-order lower than that of the target casing. (author)

  4. Development of IFE target systems on the NIF

    International Nuclear Information System (INIS)

    Schultz, K.R.; Fagaly, R.L.; Bernat, T.; Meier, W.; Petzoldt, R.; Foreman, L.

    1995-01-01

    The Target Systems session of the Workshop on NIF Experiments for IFE developed a list of critical issues for inertial fusion energy (IFE) target systems, and considered the potential of the National Ignition Facility (NIF) to help in the resolution of these issues and in the development of IFE target systems. This paper describes the IFE Target System issues, categorized into target fabrication issues and target transport issues, describes potential NIF IFE target systems experiments, considers the impact of these experiments on the NIF and discusses the development required before these experiments could be done. Most target systems issues must be resolved by development in the laboratory, not in the NIF, and some must be resolved before the NIF can be successful. However, experiments done in the NIF could play a valuable role in developing target systems for IFE. These experiments should have modest impact on the basic design of the NIF, but could require several hundred dedicated, high yield shots

  5. Shielding design for the target room of the proton accelerator research center

    International Nuclear Information System (INIS)

    Min, Y. S.; Lee, C. W.; Mun, K. J.; Nam, J.; Kim, J. Y.

    2010-01-01

    The Proton Engineering Frontier Project (PEFP) has been developing a 100-MeV proton linear accelerator. Also, PEFP has been designing the Proton Accelerator Research Center (PARC). In the Accelerator Tunnel and Beam Experiment Hall in PARC, 10 target rooms for the 20- and 100-MeV beamline facilities exist in the Beam Experiment Hall. For the 100-MeV target rooms during 100-MeV proton beam extraction, a number of high energy neutrons, ranging up to 100-MeV, are produced. Because of the high beam current and space limitations of each target room, the shielding design of each target room should be considered seriously. For the shielding design of the 100-MeV target rooms of the PEFP, a permanent and removable local shield structure was adopted. To optimize shielding performance, we evaluated four different shield materials (concrete, HDPE, lead, iron). From the shielding calculation results, we confirmed that the proposed shielding design made it possible to keep the dose rate below the 'as low as reasonably achievable (ALARA)' objective.

  6. Design of the Next Generation Target at the Lujan Neutron Scattering Center, LANSCE

    Energy Technology Data Exchange (ETDEWEB)

    Ferres, Laurent [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); National Graduate School of Engineering and Research Center (ENSICAEN), Caen (France)

    2016-08-03

    Los Alamos National Laboratory (LANL) supports scientific research in many diverse fields such as biology, chemistry, and nuclear science. The Laboratory was established in 1943 during the Second World War to develop nuclear weapons. Today, LANL is one of the largest laboratories dedicated to nuclear defense and operates an 800 MeV proton linear accelerator for basic and applied research including: production of high- and low-energy neutrons beams, isotope production for medical applications and proton radiography. This accelerator is located at the Los Alamos Neutron Science Center (LANSCE). The work performed involved the redesign of the target for the low-energy neutron source at the Lujan Neutron Scattering Center, which is one of the facilities built around the accelerator. The redesign of the target involves modeling various arrangements of the moderator-reflector-shield for the next generation neutron production target. This is done using Monte Carlo N-Particle eXtended (MCNPX), and ROOT analysis framework, a C++ based-software, to analyze the results.

  7. Magnetic biosensor system to detect biological targets

    KAUST Repository

    Li, Fuquan; Gooneratne, Chinthaka Pasan; Kosel, Jü rgen

    2012-01-01

    magnetic concentration, magnetic as well as mechanical trapping and magnetic sensing. Target detection is based on the size difference between bare magnetic beads and magnetic beads with targets attached. This method remedies the need for a coating layer

  8. Distribution control centers in the Croatian power system with particular consideration on ZAgreb distribution control center

    International Nuclear Information System (INIS)

    Cupin, N.

    2000-01-01

    Discussion about control of Croatian Power system in the view of forthcoming free electricity market did not included do far distribution level. With this article we would like to clarify the role of distribution control centers pointing out importance of Zagreb Distribution control center, with controls one third of Croatian (HEP) consumption. (author)

  9. On the evolution of stellar systems with a massive center

    International Nuclear Information System (INIS)

    Gurzadyan, V.G.; Kocharyan, A.A.

    1986-01-01

    The evolution of stellar systems with the massive center is investigated within the framework of dynamic system theory. Open dissipative systems, for which the Liouville theorem of the phase volume preservation is not implemented, are considered. Equations determining variation, in time, of main physical system parameters have been derived and studied. Results of the investigation show a principal possibility for determining the evolution path of stellar systems with the massive centers depending on physical parameters

  10. Automation in irradiating target systems for cyclotrons

    International Nuclear Information System (INIS)

    Araujo, Sumair G.; Sciani, Valdir; Almeida, Rosemeire S.

    2000-01-01

    Nowadays, two cyclotron are being operated at IPEN-CNEN/SP: one model CV-28, capable of accelerating p, d, 3 He 4 and α, with energies of 24, 14, 36 and 28 MeV, respectively, and beam currents up to 30 μA; the other one, model cyclone 30, accelerates protons with energy of 30 MeV and currents up to 350 μ A. Both have the objective of irradiating targets both for radioisotope production for use in Nuclear Medicine, such as 67 Ga, 201 Tl, 111 In, 123 I, 18 F, and general research. The development of irradiating systems completely automatized was the objective of this work, always aiming to reduce the radiation exposition dose to the workers and to increasing the reliability of use of these systems, because very high activities are expected in these processes. In the automation, a Programmable Logical Controller (PLC) was used connected to a feedback net, to manage all the variables involved in the irradiation processes. The program of the PLC was developed using Simatic Step Seven (S7), Software from Siemens, where all the steps are supervised in screens at a microcomputer. The assembling and sequence of leading were developed using the software from Unisoft, that keeps the operator informed about the work being carried out, at any time. (author)

  11. National Finance Center Personnel/Payroll System

    Data.gov (United States)

    US Agency for International Development — The NFC system is an USDA system used for processing transactions for payroll/personnel systems. Personnel processing is done through EPIC/HCUP, which is web-based....

  12. Microsoft System Center 2012 R2 compliance management cookbook

    CERN Document Server

    Baumgarten, Andreas; Roesner, Susan

    2014-01-01

    Whether you are an IT manager, an administrator, or security professional who wants to learn how Microsoft Security Compliance Manager and Microsoft System Center can help fulfil compliance and security requirements, this is the book for you. Prior knowledge of Microsoft System Center is required.

  13. FY17 Transportation and Hydrogen Systems Center Journal Publication Highlights

    Energy Technology Data Exchange (ETDEWEB)

    2017-12-08

    NREL's Transportation and Hydrogen Systems Center published 39 journal articles in fiscal year 2017 highlighting recent research in advanced vehicle technology, alternative fuels, and hydrogen systems.

  14. A Comparison of Organization-Centered and Agent-Centered Multi-Agent Systems

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Villadsen, Jørgen

    2013-01-01

    Whereas most classical multi-agent systems have the agent in center, there has recently been a development towards focusing more on the organization of the system, thereby allowing the designer to focus on what the system goals are, without considering how the goals should be fulfilled. We have d...

  15. Training Center for Industrial Control Systems

    Directory of Open Access Journals (Sweden)

    V. D. Yezhov

    2013-01-01

    Full Text Available We consider the application of embedded microcontrollers and industrial controllers with built-in operating systems.With the development of embedded operating systems and technology of open standard IEC 61131-3 product developer can write their own program management and support staff – to modernize management program.

  16. Magnetic biosensor system to detect biological targets

    KAUST Repository

    Li, Fuquan

    2012-09-01

    Magneto-resistive sensors in combination with magnetic beads provide sensing platforms, which are small in size and highly sensitive. These platforms can be fully integrated with microchannels and electronics to enable devices capable of performing complex tasks. Commonly, a sandwich method is used that requires a specific coating of the sensor\\'s surface to immobilize magnetic beads and biological targets on top of the sensor. This paper concerns a micro device to detect biological targets using magnetic concentration, magnetic as well as mechanical trapping and magnetic sensing. Target detection is based on the size difference between bare magnetic beads and magnetic beads with targets attached. This method remedies the need for a coating layer and reduces the number of steps required to run an experiment. © 2012 IEEE.

  17. Development and Testing of the Glenn Research Center Visitor's Center Grid-Tied Photovoltaic Power System

    Science.gov (United States)

    Eichenberg, Dennis J.

    2009-01-01

    The NASA Glenn Research Center (GRC) has developed, installed, and tested a 12 kW DC grid-tied photovoltaic (PV) power system at the GRC Visitor s Center. This system utilizes a unique ballast type roof mount for installing the photovoltaic panels on the roof of the Visitor s Center with no alterations or penetrations to the roof. The PV system has generated in excess of 15000 kWh since operation commenced in August 2008. The PV system is providing power to the GRC grid for use by all. Operation of the GRC Visitor s Center PV system has been completely trouble free. A grid-tied PV power system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility. The project transfers space technology to terrestrial use via nontraditional partners. GRC personnel glean valuable experience with PV power systems that are directly applicable to various space power systems, and provides valuable space program test data. PV power systems help to reduce harmful emissions and reduce the Nation s dependence on fossil fuels. Power generated by the PV system reduces the GRC utility demand, and the surplus power aids the community. Present global energy concerns reinforce the need for the development of alternative energy systems. Modern PV panels are readily available, reliable, efficient, and economical with a life expectancy of at least 25 years. Modern electronics has been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy of at least 25 years. Based upon the success of the GRC Visitor s Center PV system, additional PV power system expansion at GRC is under consideration. The GRC Visitor s Center grid-tied PV power system was successfully designed and developed which served to validate the basic principles

  18. Effects of Quality Improvement System for Child Care Centers

    Science.gov (United States)

    Ma, Xin; Shen, Jianping; Kavanaugh, Amy; Lu, Xuejin; Brandi, Karen; Goodman, Jeff; Till, Lance; Watson, Grace

    2011-01-01

    Using multiple years of data collected from about 100 child care centers in Palm Beach County, Florida, the authors studied whether the Quality Improvement System (QIS) made a significant impact on quality of child care centers. Based on a pre- and postresearch design spanning a period of 13 months, QIS appeared to be effective in improving…

  19. Update in Systemic and Targeted Therapies in Gastrointestinal Oncology

    Directory of Open Access Journals (Sweden)

    Nelson S. Yee

    2018-03-01

    Full Text Available Progress has been made in the treatment of gastrointestinal cancers through advances in systemic therapies, surgical interventions, and radiation therapy. At the Multi-Disciplinary Patient Care in Gastrointestinal Oncology conference, the faculty members of the Penn State Health Milton S. Hershey Medical Center presented a variety of topics that focused on this sub-specialty. This conference paper highlights the new development in systemic treatment of various malignant diseases in the digestive system. Results of the recent clinical trials that investigated the clinical efficacy of pegylated hyaluronidase, napabucasin, and L-asparaginase in pancreatic carcinoma are presented. The use of peri-operative chemotherapy comprised of 5-fluorouracil or capecitabine, leucovorin, oxaliplatin, and docetaxel (FLOT, and immunotherapy including pembrolizumab, nivolumab, and ipilimumab in gastroesophageal carcinoma are discussed. Data from clinical trials that investigated the targeted therapeutics including nivolumab, ramucirumab, lenvatinib, and BLU-554 are reported. The role of adjuvant capecitabine in resected biliary tract carcinoma (BTC and nab-paclitaxel in combination with gemcitabine and cisplatin in advanced BTC are presented. In colorectal carcinoma, the efficacy of nivolumab, adjuvant FOLFOX or CAPOX, irinotecan/cetuximab/vemurafenib, and trifluridine/tipiracil/bevacizumab, is examined. In summary, some of the above systemic therapies have become or are expected to become new standard of care, while the others demonstrate the potential of becoming new treatment options.

  20. Microsoft System Center Data Protection Manager 2012

    CERN Document Server

    Buchannan, Steve; Gomaa, Islam

    2013-01-01

    This book is a Packt tutorial, walking the administrator through the steps needed to create real solutions to the problems and tasks faced when ensuring that their data is protected. This book is for network administrators, system administrators, backup administrators, or IT consultants who are looking to expand their knowledge on how to utilize DPM to protect their organization's data.

  1. Nanomedicine: Drug Delivery Systems and Nanoparticle Targeting

    International Nuclear Information System (INIS)

    Youn, Hye Won; Kang, Keon Wook; Chung, Jun Key; Lee, Dong Soo

    2008-01-01

    Applications of nanotechnology in the medical field have provided the fundamentals of tremendous improvement in precise diagnosis and customized therapy. Recent advances in nanomedicine have led to establish a new concept of theragnosis, which utilizes nanomedicines as a therapeutic and diagnostic tool at the same time. The development of high affinity nanoparticles with large surface area and functional groups multiplies diagnostic and therapeutic capacities. Considering the specific conditions related to the disease of individual patient, customized therapy requires the identification of disease target at the cellular and molecular level for reducing side effects and enhancing therapeutic efficiency. Well-designed nanoparticles can minimize unnecessary exposure of cytotoxic drugs and maximize targeted localization of administrated drugs. This review will focus on major pharmaceutical nanomaterials and nanoparticles as key components of designing and surface engineering for targeted theragnostic drug development

  2. Center for Information Systems Research Research Briefings 2002

    OpenAIRE

    ROSS, JEANNE W.

    2003-01-01

    This paper is comprised of research briefings from the MIT Sloan School of Management's Center for Information Systems Research (CISR). CISR's mission is to perform practical empirical research on how firms generate business value from IT.

  3. Microsoft System Center 2012 R2 Operations Manager cookbook

    CERN Document Server

    Beaumont (MVP), Steve; Odika, Chiyo; Ryan, Robert

    2015-01-01

    If you are tasked with monitoring the IT infrastructure within your organization, this book demonstrates how System Center 2012 R2 Operations Manager offers a radical and exciting solution to modern administration.

  4. Target experimental area and systems of the Us national ignition facility

    International Nuclear Information System (INIS)

    Tobin, M.; Van Wonterghem, B.; MacGowan, B.J.; Hibbard, W.; Kalantar, D.; Lee, F.D.; Pittenger, L.; Wong, K.

    2000-01-01

    One of the major goals of the US National Ignition Facility is the demonstration of laser driven fusion ignition and burn of targets by inertial confinement and provide capability for a wide variety of high energy density physics experiments. The NIF target area houses the optical systems required to focus the 192 beamlets to a target precisely positioned at the center of the 10 meter diameter, 10-cm thick aluminum target chamber. The chamber serves as mounting surface for the 48 final optics assemblies, the target alignment and positioning equipment, and the target diagnostics. The internal surfaces of the chamber are protected by louvered steel beam dumps. The target area also provides the necessary shielding against target emission and environmental protection equipment. Despite its complexity, the design provides the flexibility to accommodate the needs of the various NIF user groups, such as direct and indirect drive irradiation geometries, modular final optics design, capability to handle cryogenic targets, and easily re-configurable diagnostic instruments. Efficient target area operations are ensured by using line-replaceable designs for systems requiring frequent inspection, maintenance and reconfiguration, such as the final optics, debris shields, phase plates and the diagnostic instruments. A precision diagnostic instrument manipulator (DIMS) allows fast removal and precise repositioning of diagnostic instruments. In addition we will describe several activities to enhance the target chamber availability, such as the target debris mitigation, the use of standard experimental configurations and the development of smart shot operations planning tools. (authors)

  5. Target experimental area and systems of the U.S. National Ignition Facility

    International Nuclear Information System (INIS)

    Tobin, M; Van Wonterghem, B; MacGowan, B J; Hibbard, W; Kalantar, D; Lee, F D; Pittenger, L; Wong, K

    1999-01-01

    One of the major goals of the US National Ignition Facility is the demonstration of laser driven fusion ignition and burn of targets by inertial confinement and provide capability for a wide variety of high energy density physics experiments. The NIF target area houses the optical systems required to focus the 192 beamlets to a target precisely positioned at the center of the 10 meter diameter, 10-cm thick aluminum target chamber. The chamber serves as mounting surface for the 48 final optics assemblies, the target alignment and positioning equipment, and the target diagnostics. The internal surfaces of the chamber are protected by louvered steel beam dumps. The target area also provides the necessary shielding against target emission and environmental protection equipment. Despite its complexity, the design provides the flexibility to accommodate the needs of the various NIF user groups, such as direct and indirect drive irradiation geometries, modular final optics design, capability to handle cryogenic targets, and easily re-configurable diagnostic instruments. Efficient target area operations are ensured by using line-replaceable designs for systems requiring frequent inspection, maintenance and reconfiguration, such as the final optics, debris shields, phase plates and the diagnostic instruments. A precision diagnostic instrument manipulator (DIMS) allows fast removal and precise repositioning of diagnostic instruments. In addition the authors describe several activities to enhance the target chamber availability, such as the target debris mitigation, the use of standard experimental configurations and the development of smart shot operations planning tools

  6. Repetitive output laser system and method using target reflectivity

    International Nuclear Information System (INIS)

    Johnson, R.R.

    1978-01-01

    An improved laser system and method for implosion of a thermonuclear fuel pellet is described in which that portion of a laser pulse reflected by the target pellet is utilized in the laser system to initiate a succeeding target implosion, and in which the energy stored in the laser system to amplify the initial laser pulse, but not completely absorbed thereby, is used to amplify succeeding laser pulses initiated by target refγlection

  7. A beam sweeping system for the Fermilab antiproton production target

    International Nuclear Information System (INIS)

    Bieniosek, F.M.

    1993-08-01

    In the Main Injector era beam intensities high enough to damage the antiproton production target will be available. In order to continue to operate with a tightly-focused primary beam spot on the target, and thus maintain yield, it will be necessary to spread the hot spot on the target by use of a beam sweeping system. This report summarizes the requirements for such a system, and addresses the issues involved in the design of a sweeping system

  8. Detection technique of targets for missile defense system

    Science.gov (United States)

    Guo, Hua-ling; Deng, Jia-hao; Cai, Ke-rong

    2009-11-01

    Ballistic missile defense system (BMDS) is a weapon system for intercepting enemy ballistic missiles. It includes ballistic-missile warning system, target discrimination system, anti-ballistic-missile guidance systems, and command-control communication system. Infrared imaging detection and laser imaging detection are widely used in BMDS for surveillance, target detection, target tracking, and target discrimination. Based on a comprehensive review of the application of target-detection techniques in the missile defense system, including infrared focal plane arrays (IRFPA), ground-based radar detection technology, 3-dimensional imaging laser radar with a photon counting avalanche photodiode (APD) arrays and microchip laser, this paper focuses on the infrared and laser imaging detection techniques in missile defense system, as well as the trends for their future development.

  9. A Gas Target with a Tritium Gas Handling System

    Energy Technology Data Exchange (ETDEWEB)

    Holmqvist, B; Wiedling, T

    1963-12-15

    A detailed description is given of a simple tritium gas target and its tritium gas filling system, and how to put it into operation. By using the T (p,n) He reaction the gas target has been employed for production of monoenergetic fast neutrons of well defined energy and high intensity. The target has been operated successfully for a long time.

  10. Feasibility of target communities in a Dutch brook valley system

    NARCIS (Netherlands)

    Prins, AH; Bekker, RM

    As a reaction to the ongoing deterioration of nature conservation interest in The Netherlands, an offensive nature strategy was formulated in the 1990 Nature Policy Plan. In this Plan, target communities and target plant species are mentioned. For the 'Drentse A brook valley system', target

  11. Marshall Space Flight Center Ground Systems Development and Integration

    Science.gov (United States)

    Wade, Gina

    2016-01-01

    Ground Systems Development and Integration performs a variety of tasks in support of the Mission Operations Laboratory (MOL) and other Center and Agency projects. These tasks include various systems engineering processes such as performing system requirements development, system architecture design, integration, verification and validation, software development, and sustaining engineering of mission operations systems that has evolved the Huntsville Operations Support Center (HOSC) into a leader in remote operations for current and future NASA space projects. The group is also responsible for developing and managing telemetry and command configuration and calibration databases. Personnel are responsible for maintaining and enhancing their disciplinary skills in the areas of project management, software engineering, software development, software process improvement, telecommunications, networking, and systems management. Domain expertise in the ground systems area is also maintained and includes detailed proficiency in the areas of real-time telemetry systems, command systems, voice, video, data networks, and mission planning systems.

  12. Tumor target amplification: Implications for nano drug delivery systems.

    Science.gov (United States)

    Seidi, Khaled; Neubauer, Heidi A; Moriggl, Richard; Jahanban-Esfahlan, Rana; Javaheri, Tahereh

    2018-04-10

    Tumor cells overexpress surface markers which are absent from normal cells. These tumor-restricted antigenic signatures are a fundamental basis for distinguishing on-target from off-target cells for ligand-directed targeting of cancer cells. Unfortunately, tumor heterogeneity impedes the establishment of a solid expression pattern for a given target marker, leading to drastic changes in quality (availability) and quantity (number) of the target. Consequently, a subset of cancer cells remains untargeted during the course of treatment, which subsequently promotes drug-resistance and cancer relapse. Since target inefficiency is only problematic for cancer treatment and not for treatment of other pathological conditions such as viral/bacterial infections, target amplification or the generation of novel targets is key to providing eligible antigenic markers for effective targeted therapy. This review summarizes the limitations of current ligand-directed targeting strategies and provides a comprehensive overview of tumor target amplification strategies, including self-amplifying systems, dual targeting, artificial markers and peptide modification. We also discuss the therapeutic and diagnostic potential of these approaches, the underlying mechanism(s) and established methodologies, mostly in the context of different nanodelivery systems, to facilitate more effective ligand-directed cancer cell monitoring and targeting. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. The Nuclotron internal target control and data acquisition system

    Energy Technology Data Exchange (ETDEWEB)

    Isupov, A.Yu., E-mail: isupov@moonhe.jinr.ru [Joint Institute for Nuclear Research, Dubna 141980 (Russian Federation); Krasnov, V.A.; Ladygin, V.P.; Piyadin, S.M.; Reznikov, S.G. [Joint Institute for Nuclear Research, Dubna 141980 (Russian Federation)

    2013-01-11

    The new control system of the Nuclotron (JINR, Dubna) internal target is described in both hardware and software aspects. The CAMAC hardware is based on the use of the standard CAMAC modules developed and manufactured at JINR. The internal target control and data acquisition (IntTarg CDAQ) system software is implemented using the ngdp framework under the Unix-like operating system (OS) FreeBSD to allow easy network distribution of the online data collected from internal target and accompanying detectors, as well as the internal target remote control.

  14. Monetary targeting and financial system characteristics : An empirical analysis

    NARCIS (Netherlands)

    Samarina, A..

    2012-01-01

    This paper investigates how reforms and characteristics of the financial system affect the likelihood of countries to abandon their strategy of monetary targeting. Apart from financial system characteristics, we include macroeconomic, fiscal, and institutional factors potentially associated with

  15. The NA50 segmented target and vertex recognition system

    International Nuclear Information System (INIS)

    Bellaiche, F.; Cheynis, B.; Contardo, D.; Drapier, O.; Grossiord, J.Y.; Guichard, A.; Haroutunian, R.; Jacquin, M.; Ohlsson-Malek, F.; Pizzi, J.R.

    1997-01-01

    The NA50 segmented target and vertex recognition system is described. The segmented target consists of 7 sub-targets of 1-2 mm thickness. The vertex recognition system used to determine the sub-target where an interaction has occured is based upon quartz elements which produce Cerenkov light when traversed by charged particles from the interaction. The geometrical arrangement of the quartz elements has been optimized for vertex recognition in 208 Pb-Pb collisions at 158 GeV/nucleon. A simple algorithm provides a vertex recognition efficiency of better than 85% for dimuon trigger events collected with a 1 mm sub-target set-up. A method for recognizing interactions of projectile fragments (nuclei and/or groups of nucleons) is presented. The segmented target allows a large target thickness which together with a high beam intensity (∼10 7 ions/s) enables high statistics measurements. (orig.)

  16. A Dynamic and Interactive Monitoring System of Data Center Resources

    Directory of Open Access Journals (Sweden)

    Yu Ling-Fei

    2016-01-01

    Full Text Available To maximize the utilization and effectiveness of resources, it is very necessary to have a well suited management system for modern data centers. Traditional approaches to resource provisioning and service requests have proven to be ill suited for virtualization and cloud computing. The manual handoffs between technology teams were also highly inefficient and poorly documented. In this paper, a dynamic and interactive monitoring system for data center resources, ResourceView, is presented. By consolidating all data center management functionality into a single interface, ResourceView shares a common view of the timeline metric status, while providing comprehensive, centralized monitoring of data center physical and virtual IT assets including power, cooling, physical space and VMs, so that to improve availability and efficiency. In addition, servers and VMs can be monitored from several viewpoints such as clusters, racks and projects, which is very convenient for users.

  17. Vision-Based Target Finding and Inspection of a Ground Target Using a Multirotor UAV System.

    Science.gov (United States)

    Hinas, Ajmal; Roberts, Jonathan M; Gonzalez, Felipe

    2017-12-17

    In this paper, a system that uses an algorithm for target detection and navigation and a multirotor Unmanned Aerial Vehicle (UAV) for finding a ground target and inspecting it closely is presented. The system can also be used for accurate and safe delivery of payloads or spot spraying applications in site-specific crop management. A downward-looking camera attached to a multirotor is used to find the target on the ground. The UAV descends to the target and hovers above the target for a few seconds to inspect the target. A high-level decision algorithm based on an OODA (observe, orient, decide, and act) loop was developed as a solution to address the problem. Navigation of the UAV was achieved by continuously sending local position messages to the autopilot via Mavros. The proposed system performed hovering above the target in three different stages: locate, descend, and hover. The system was tested in multiple trials, in simulations and outdoor tests, from heights of 10 m to 40 m. Results show that the system is highly reliable and robust to sensor errors, drift, and external disturbance.

  18. Challenges Surrounding the Injection and Arrival of Targets at LIFE Fusion Chamber Center

    Energy Technology Data Exchange (ETDEWEB)

    Miles, R; Spaeth, M; Manes, K; Amendt, P; Tabak, M; Bond, T; Kucheyev, S; Latkowski, J; Loosmore, G; Bliss, E; Baker, K; Bhandarkar, S; Petzoldt, R; Alexander, N; Tillack, M; Holdener, D

    2010-12-01

    IFE target designers must consider several engineering requirements in addition to the physics requirements for successful target implosion. These considerations include low target cost, high manufacturing throughput, the ability of the target to survive the injection into the fusion chamber and arrive in a condition and physical position consistent with proper laser-target interaction and ease of post-implosion debris removal. This article briefly describes these considerations for the Laser Inertial Fusion-based Energy (LIFE) targets currently being designed.

  19. The advantages of reliability centered maintenance for standby safety systems

    International Nuclear Information System (INIS)

    Dam, R.F.; Ayazzudin, S.; Nickerson, J.H.; DeLong, A.I.

    2002-01-01

    Full text: On standby safety systems, nuclear plants have to balance the requirements of demonstrating the reliability of each system, while maintaining the system and plant availability. With the goal of demonstrating statistical reliability, these systems have extensive testing programs, which often makes the system unavailable and this can impact the plant capacity. The inputs to the process are often safety and regulatory related, resulting in programs that provide a high level of scrutiny on the systems being considered. In such cases, the value of the application of a maintenance optimization strategy, such as Reliability Centered Maintenance (RCM), is questioned. Part of the question stems from the use of the word 'Reliability' in RCM, which implies a level of redundancy when applied to a system maintenance program driven by reliability requirements. A deeper look at the RCM process, however, shows that RCM has the goal of ensuring that the system operates 'reliably' through the application of an integrated maintenance strategy. This is a subtle, but important distinction. Although the system reliability requirements are an important part of the strategy evaluation, RCM provides a broader context where testing is only one part of an overall strategy focused on ensuring that component function is maintained through a combination of monitoring technologies (including testing), predictive techniques, and intrusive maintenance strategies. Each strategy is targeted to identify known component degradation mechanisms. The conclusion is that a maintenance program driven by reliability requirements will tend to have testing defined at a frequency intended to support the needed statistics. The testing demonstrates that the desired function is available today. Maintenance driven by functional requirements and known failure causes, as developed through an RCM assessment, will have frequencies tied to industry experience with components and rely on a higher degree of

  20. Active Multimodal Sensor System for Target Recognition and Tracking.

    Science.gov (United States)

    Qu, Yufu; Zhang, Guirong; Zou, Zhaofan; Liu, Ziyue; Mao, Jiansen

    2017-06-28

    High accuracy target recognition and tracking systems using a single sensor or a passive multisensor set are susceptible to external interferences and exhibit environmental dependencies. These difficulties stem mainly from limitations to the available imaging frequency bands, and a general lack of coherent diversity of the available target-related data. This paper proposes an active multimodal sensor system for target recognition and tracking, consisting of a visible, an infrared, and a hyperspectral sensor. The system makes full use of its multisensor information collection abilities; furthermore, it can actively control different sensors to collect additional data, according to the needs of the real-time target recognition and tracking processes. This level of integration between hardware collection control and data processing is experimentally shown to effectively improve the accuracy and robustness of the target recognition and tracking system.

  1. BASIN-CENTERED GAS SYSTEMS OF THE U.S.

    Energy Technology Data Exchange (ETDEWEB)

    Marin A. Popov; Vito F. Nuccio; Thaddeus S. Dyman; Timothy A. Gognat; Ronald C. Johnson; James W. Schmoker; Michael S. Wilson; Charles Bartberger

    2000-11-01

    The USGS is re-evaluating the resource potential of basin-centered gas accumulations in the U.S. because of changing perceptions of the geology of these accumulations, and the availability of new data since the USGS 1995 National Assessment of United States oil and gas resources (Gautier et al., 1996). To attain these objectives, this project used knowledge of basin-centered gas systems and procedures such as stratigraphic analysis, organic geochemistry, modeling of basin thermal dynamics, reservoir characterization, and pressure analysis. This project proceeded in two phases which had the following objectives: Phase I (4/1998 through 5/1999): Identify and describe the geologic and geographic distribution of potential basin-centered gas systems, and Phase II (6/1999 through 11/2000): For selected systems, estimate the location of those basin-centered gas resources that are likely to be produced over the next 30 years. In Phase I, we characterize thirty-three (33) potential basin-centered gas systems (or accumulations) based on information published in the literature or acquired from internal computerized well and reservoir data files. These newly defined potential accumulations vary from low to high risk and may or may not survive the rigorous geologic scrutiny leading towards full assessment by the USGS. For logistical reasons, not all basins received the level of detail desired or required.

  2. Block Fusion Systems and the Center of the Group Ring

    DEFF Research Database (Denmark)

    Jacobsen, Martin Wedel

    This thesis develops some aspects of the theory of block fusion systems. Chapter 1 contains a brief introduction to the group algebra and some simple results about algebras over a field of positive characteristic. In chapter 2 we define the concept of a fusion system and the fundamental property...... of saturation. We also define block fusion systems and prove that they are saturated. Chapter 3 develops some tools for relating block fusion systems to the structure of the center of the group algebra. In particular, it is proven that a block has trivial defect group if and only if the center of the block...... algebra is one-dimensional. Chapter 4 consists of a proof that block fusion systems of symmetric groups are always group fusion systems of symmetric groups, and an analogous result holds for the alternating groups....

  3. DOE Heat Pump Centered Integrated Community Energy Systems Project

    Energy Technology Data Exchange (ETDEWEB)

    Calm, J. M.

    1979-01-01

    The Heat Pump Centered Integrated Community Energy Systems (HP-ICES) Project is a multiphase undertaking seeking to demonstrate one or more operational HP-ICES by the end of 1983. The seven phases include System Development, Demonstration Design, Design Completion, HP-ICES Construction, Operation and Data Acquisition, HP-ICES Evaluation, and Upgraded Continuation. This project is sponsored by the Community Systems Branch, Office of Buildings and Community Systems, Assistant Secretary for Conservation and Solar Applicaions, U.S. Department of Energy (DOE). It is part of the Community Systems Program and is managed by the Energy and Environmental Systems Division of Argonne Natinal Laboratory.

  4. University of Rhode Island Regional Earth Systems Center

    Energy Technology Data Exchange (ETDEWEB)

    Rothstein, Lewis [Univ. of Rhode Island, Kingston, RI (United States); Cornillon, P. [Univ. of Rhode Island, Kingston, RI (United States)

    2017-02-06

    The primary objective of this program was to establish the URI Regional Earth System Center (“Center”) that would enhance overall societal wellbeing (health, financial, environmental) by utilizing the best scientific information and technology to achieve optimal policy decisions with maximum stakeholder commitment for energy development, coastal environmental management, water resources protection and human health protection, while accelerating regional economic growth. The Center was to serve to integrate existing URI institutional strengths in energy, coastal environmental management, water resources, and human wellbeing. This integrated research, educational and public/private sector outreach Center was to focus on local, state and regional resources. The centerpiece activity of the Center was in the development and implementation of integrated assessment models (IAMs) that both ‘downscaled’ global observations and interpolated/extrapolated regional observations for analyzing the complexity of interactions among humans and the natural climate system to further our understanding and, ultimately, to predict the future state of our regional earth system. The Center was to begin by first ‘downscaling’ existing global earth systems management tools for studying the causes of local, state and regional climate change and potential social and environmental consequences, with a focus on the regional resources identified above. The Center would ultimately need to address the full feedbacks inherent in the nonlinear earth systems by quantifying the “upscaled” impacts of those regional changes on the global earth system. Through an interacting suite of computer simulations that are informed by observations from the nation’s evolving climate observatories, the Center activities integrates climate science, technology, economics, and social policy into forecasts that will inform solutions to pressing issues in regional climate change science,

  5. Establishment of protein delivery systems targeting podocytes.

    Directory of Open Access Journals (Sweden)

    Wen Chih Chiang

    2010-07-01

    Full Text Available Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular capillaries expose podocytes to large quantities of both plasma and urinary components and thus are reachable for drug delivery. Recent years have made clear that interference with podocyte-specific disease pathways can modulate glomerular function and influence severity and progression of glomerular disease.Here, we describe studies that show efficient transport of proteins into the mammalian cells mouse 3T3 fibroblasts and podocytes, utilizing an approach termed profection. We are using synthetic lipid structures that allow the safe packing of proteins or antibodies resulting in the subsequent delivery of protein into the cell. The uptake of lipid coated protein is facilitated by the intrinsic characteristic of cells such as podocytes to engulf particles that are physiologically retained in the extracellular matrix. Profection of the restriction enzyme MunI in 3T3 mouse fibroblasts caused an increase in DNA degradation. Moreover, purified proteins such as beta-galactosidase and the large GTPase dynamin could be profected into podocytes using two different profection reagents with the success rate of 95-100%. The delivered beta-galactosidase enzyme was properly folded and able to cleave its substrate X-gal in podocytes. Diseased podocytes are also potential recipients of protein cargo as we also delivered fluorophore labeled IgG into puromycin treated podocytes. We are currently optimizing our protocol for in vivo profection.Protein transfer is developing as an exciting tool to study and target highly differentiated cells such as podocytes.

  6. A two-cassette reporter system for assessing target gene translation and target gene product inclusion body formation

    DEFF Research Database (Denmark)

    2016-01-01

    The present invention relates to a dual cassette reporter system capable of assessing target gene translation and target gene product folding. The present invention further relates to vectors and host cells comprising the dual cassette reporter system. In addition the invention relates to the use...... of the dual cassette reporter system for assessing target gene translation and target gene product folding....

  7. System for measuring the proton polarization in a polarized target

    International Nuclear Information System (INIS)

    Karnaukhov, I.M.; Lukhanin, A.A.; Telegin, Yu.N.; Trotsenko, V.I.; Chechetenko, V.F.

    1984-01-01

    The system for measuring the proton polarization in a polarized target representing the high-sensitivity nuclear magnetic resonance (NMR) is described Q-meter with series connection and a circuit for measuring system resonance characteristic is used for NMR-absorption signal recording. Measuring coil is produced of a strip conductor in order to obtain uniform system sensitivity to polarization state in all target volume and improve signal-to-noise ratio. Polarization measuring system operates ion-line with the M-6000 computer. The total measuring error for the value of free proton polarization in target taking into account the error caused by local depolarization of working substance under irradiation by high-intense photon beam is <= 6%. Long-term application of the described system for measuring the proton polarization in the LUEh-20000 accelerator target used in the pion photoproduction experiments has demonstrated its high reliability

  8. The evaluation study of high performance gas target system

    International Nuclear Information System (INIS)

    Hur, Min Goo; Yang, Seung Dae; Kim, Sang Wook

    2008-06-01

    The object of this study is a improvement of a gas target and targetry for increasing the radioisotope production yields. The main results are as follows 1. Improvement of beam entrance of the gas target : In this work, deep hole grid was designed for improvement of beam entrance. Using FEM(Finite Elements Method) analysis, it was verified that this design is more effective than the old one. 2. Improvement of target gas loading and withdrawing system : For the targetry, Helium gas and vacuum lines was installed for evaluating the production yields. Using these lines, it was proved that the recovery yields was improved and the residual impurity was reduced. 3. Improvement of target cooling efficiency : In case of the cylindrical target, it is more effective to use short length of target cavity for the high production yields. For improving the cooling efficiency, cooling fin was suggested to the target design. It is more effective to put the cooling fins inside the target cavity for the suppressed target pressure and density reduction effect during the proton beam irradiation. In conclusion, the target with fins inside the target cavity was better for high current irradiation and mass RI production

  9. The evaluation study of high performance gas target system

    Energy Technology Data Exchange (ETDEWEB)

    Hur, Min Goo; Yang, Seung Dae; Kim, Sang Wook

    2008-06-15

    The object of this study is a improvement of a gas target and targetry for increasing the radioisotope production yields. The main results are as follows 1. Improvement of beam entrance of the gas target : In this work, deep hole grid was designed for improvement of beam entrance. Using FEM(Finite Elements Method) analysis, it was verified that this design is more effective than the old one. 2. Improvement of target gas loading and withdrawing system : For the targetry, Helium gas and vacuum lines was installed for evaluating the production yields. Using these lines, it was proved that the recovery yields was improved and the residual impurity was reduced. 3. Improvement of target cooling efficiency : In case of the cylindrical target, it is more effective to use short length of target cavity for the high production yields. For improving the cooling efficiency, cooling fin was suggested to the target design. It is more effective to put the cooling fins inside the target cavity for the suppressed target pressure and density reduction effect during the proton beam irradiation. In conclusion, the target with fins inside the target cavity was better for high current irradiation and mass RI production.

  10. Unmanned Aircraft Systems (UAS) Sensor and Targeting

    Science.gov (United States)

    2010-07-27

    Identify an uncoiled garden hose lying on the ground. 8.2 Identify specific type of truck crop being grown (e.g., tomatoes, peppers, lettuce ). 8.2... lettuce ). (NIIRS 8.2) Detect scoring of poppy bulbs. (NIIRS 8.5) Detect tubing (approximately 1-inch diameter) for drip irrigation systems. (NIIR5 8.5...trial can be presented as a time history for each axis. A sample is shown in Figures C.1-3 and C.1-4. TOP 07-1-003 27 July 2010 C-2

  11. Treat-to-target in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    van Vollenhoven, Ronald F; Mosca, Marta; Bertsias, George

    2014-01-01

    guidance for healthcare providers and administrators. Thus, an initiative to evaluate possible therapeutic targets and develop treat-to-target guidance was believed to be highly appropriate in the management of systemic lupus erythematosus (SLE) patients as well. Specialists in rheumatology, nephrology...

  12. World Key Information Service System Designed For EPCOT Center

    Science.gov (United States)

    Kelsey, J. A.

    1984-03-01

    An advanced Bell Laboratories and Western Electric designed electronic information retrieval system utilizing the latest Information Age technologies, and a fiber optic transmission system is featured at the Walt Disney World Resort's newest theme park - The Experimental Prototype Community of Tomorrow (EPCOT Center). The project is an interactive audio, video and text information system that is deployed at key locations within the park. The touch sensitive terminals utilizing the ARIEL (Automatic Retrieval of Information Electronically) System is interconnected by a Western Electric designed and manufactured lightwave transmission system.

  13. Targeting herpesvirus reliance of the chemokine system

    DEFF Research Database (Denmark)

    Rosenkilde, Mette M; Kledal, Thomas N

    2006-01-01

    the infection. However, since both virus and host exist, the organisms struggle must reach an ecological equilibrium. Among the best-studied interactions between viruses and the host immune system are those between herpesviruses and their hosts. Herpesviruses are known to devote a significant part...... of their large genomes on immuno-modulatory genes, some encoding chemokines or chemokine receptors. These genes, which may be dispensable for viral replication in vitro, are highly important for viral growth in vivo, for viral dissemination and disease progression. Indeed, all beta and gamma-herpesviruses have...... chemokine receptors seems to be their constitutive activity. The biological function of the constitutive activity is still unclear, but it has become clear that the receptors are involved in important parts of the viral lifecycle in vivo, and that the receptor signaling is involved in gamma-herpesvirus...

  14. Multiple operating system rotation environment moving target defense

    Science.gov (United States)

    Evans, Nathaniel; Thompson, Michael

    2016-03-22

    Systems and methods for providing a multiple operating system rotation environment ("MORE") moving target defense ("MTD") computing system are described. The MORE-MTD system provides enhanced computer system security through a rotation of multiple operating systems. The MORE-MTD system increases attacker uncertainty, increases the cost of attacking the system, reduces the likelihood of an attacker locating a vulnerability, and reduces the exposure time of any located vulnerability. The MORE-MTD environment is effectuated by rotation of the operating systems at a given interval. The rotating operating systems create a consistently changing attack surface for remote attackers.

  15. MOD control center automated information systems security evolution

    Science.gov (United States)

    Owen, Rich

    1991-01-01

    The role of the technology infusion process in future Control Center Automated Information Systems (AIS) is highlighted. The following subject areas are presented in the form of the viewgraphs: goals, background, threat, MOD's AISS program, TQM, SDLC integration, payback, future challenges, and bottom line.

  16. Performance evaluation of a center pivot variable rate irrigation system

    Science.gov (United States)

    Variable Rate Irrigation (VRI) for center pivots offers potential to match specific application rates to non-uniform soil conditions along the length of the lateral. The benefit of such systems is influenced by the areal extent of these variations and the smallest scale to which the irrigation syste...

  17. Microsoft System Center Data Protection Manager 2012 R2 cookbook

    CERN Document Server

    Hedblom, Robert

    2015-01-01

    If you are a DPM administrator, this book will help you verify your knowledge and provide you with everything you need to know about the 2012 R2 release. No prior knowledge about System Center DPM is required, however some experience of running backups will come in handy.

  18. Development of a higher power cooling system for lithium targets.

    Science.gov (United States)

    Phoenix, B; Green, S; Scott, M C; Bennett, J R J; Edgecock, T R

    2015-12-01

    The accelerator based Boron Neutron Capture Therapy beam at the University of Birmingham is based around a solid thick lithium target cooled by heavy water. Significant upgrades to Birmingham's Dynamitron accelerator are planned prior to commencing a clinical trial. These upgrades will result in an increase in maximum achievable beam current to at least 3 mA. Various upgrades to the target cooling system to cope with this increased power have been investigated. Tests of a phase change coolant known as "binary ice" have been carried out using an induction heater to provide a comparable power input to the Dynamitron beam. The experimental data shows no improvement over chilled water in the submerged jet system, with both systems exhibiting the same heat input to target temperature relation for a given flow rate. The relationship between the cooling circuit pumping rate and the target temperature in the submerged jet system has also been tested. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. System security in the space flight operations center

    Science.gov (United States)

    Wagner, David A.

    1988-01-01

    The Space Flight Operations Center is a networked system of workstation-class computers that will provide ground support for NASA's next generation of deep-space missions. The author recounts the development of the SFOC system security policy and discusses the various management and technology issues involved. Particular attention is given to risk assessment, security plan development, security implications of design requirements, automatic safeguards, and procedural safeguards.

  20. Lewis Research Center space station electric power system test facilities

    Science.gov (United States)

    Birchenough, Arthur G.; Martin, Donald F.

    1988-01-01

    NASA Lewis Research Center facilities were developed to support testing of the Space Station Electric Power System. The capabilities and plans for these facilities are described. The three facilities which are required in the Phase C/D testing, the Power Systems Facility, the Space Power Facility, and the EPS Simulation Lab, are described in detail. The responsibilities of NASA Lewis and outside groups in conducting tests are also discussed.

  1. NASA Space Engineering Research Center for VLSI systems design

    Science.gov (United States)

    1991-01-01

    This annual review reports the center's activities and findings on very large scale integration (VLSI) systems design for 1990, including project status, financial support, publications, the NASA Space Engineering Research Center (SERC) Symposium on VLSI Design, research results, and outreach programs. Processor chips completed or under development are listed. Research results summarized include a design technique to harden complementary metal oxide semiconductors (CMOS) memory circuits against single event upset (SEU); improved circuit design procedures; and advances in computer aided design (CAD), communications, computer architectures, and reliability design. Also described is a high school teacher program that exposes teachers to the fundamentals of digital logic design.

  2. A tritium target system for μCF

    International Nuclear Information System (INIS)

    Zmeskal, J.; Ackerbauer, P.; Durham, W.B.; Heard, H.C.; Neumann, W.; Bossy, H.

    1990-12-01

    An apparatus has been constructed for the safe handling of tritium as part of a series of muon-catalyzed fusion experiments. The equipment was designed to handle 100 kCi of tritium. The main parts of this system are the oil-free high vacuum and transfer system, and the quadrupole mass analyzer for a direct determination of the target content. The system was used successfully for five continuous periods of operation of over one month each. A new target system was constructed at Lawrence Livermore National Laboratory (LLNL) for ultimate use at Paul Scherrer Institute (PSI) to investigate the high temperature and high pressure region. 9 refs., 4 figs

  3. Paramagnetic centers in nanocrystalline TiC/C system

    International Nuclear Information System (INIS)

    Guskos, N.; Bodziony, T.; Maryniak, M.; Typek, J.; Biedunkiewicz, A.

    2008-01-01

    Electron paramagnetic resonance is applied to study the defect centers in nanocrystalline titanium carbide dispersed in carbon matrix (TiC x /C) synthesized by the non-hydrolytic sol-gel process. The presence of Ti 3+ paramagnetic centers is identified below 120 K along with a minor contribution from localized defect spins coupled with the conduction electron system in the carbon matrix. The temperature dependence of the resonance intensity of the latter signal indicates weak antiferromagnetic interactions. The presence of paramagnetic centers connected with trivalent titanium is suggested to be the result of chemical disorder, which can be further related to the observed anomalous behavior of conductivity, hardness, and corrosion resistance of nanocrystalline TiC x /C

  4. Cryogenic control system of the large COMPASS polarized target

    CERN Document Server

    Gautheron, F; Baum, G; Berglund, P; Doshita, N; Görtz, S; Gustafsson, K K; Horikawa, N; Kisselev, Yu V; Koivuniemi, J H; Kondo, K; Meyer, Werner T; Reicherz, G

    2004-01-01

    The dilution refrigerator used to cool the large COMPASS polarized target is monitored through a PC running LabVIEW trademark 6.1 under Windows 2000 trademark . About 60 parameters of the target (temperatures, pressures, flow rates) are continuously plotted and checked. They are periodically recorded in an Oracle trademark database and in a data file. An alarm for every parameter can be individually activated and optionally connected to a GSM (Global System for Mobile Communication) delivery message system. A web server receives and publishes the online status of the target with online tables and graphics on a dedicated COMPASS polarized target information web site. A Siemens programmable logic controller (PLC) powered by an uninterruptable source keeps the cryogenic system safe and stable during the long beam periods by controlling valves and interlocks. This safety feature protects the dilution refrigerator against potential damages in case of power failure.

  5. The evaluation study for gas target system in cyclotron

    International Nuclear Information System (INIS)

    Hur, Min Goo; Yang, Seung Dae; Kim, Sang Wook

    2009-06-01

    The object of this study is an improvement of a gas target and targetry for increasing the radioisotope production yields. The main results are as follows 1. Improvement of beam entrance of the gas target : In this work, the deep hole grid and the hex grid are compared for improvement of beam entrance. Using FEM analysis, it was verified that the hex grid design is more effective than the hole grid. 2. Improvement of target gas loading and withdrawing system : For the targetry, two type of mixture gas (N 2 +H 2 /N 2 +O 2 ) lines was installed for CH 4 /CO 2 production. Use the mixture gas than the He gas, it was proved that the recovery yields was improved and the residual impurity was reduced. 3. Compare the target yields : For improving the cooling efficiency, cooling fin was suggested to the target design. Also, we tested the production yield variation with impurity of the mixture gas. It is more effective to put the cooling fins inside the target cavity for the suppressed target pressure and density reduction effect during the proton beam irradiation. In conclusion, the target with fins inside the target cavity was better for high current irradiation and mass RI production

  6. The Research Progress of Targeted Drug Delivery Systems

    Science.gov (United States)

    Zhan, Jiayin; Ting, Xizi Liang; Zhu, Junjie

    2017-06-01

    Targeted drug delivery system (DDS) means to selectively transport drugs to targeted tissues, organs, and cells through a variety of drugs carrier. It is usually designed to improve the pharmacological and therapeutic properties of conventional drugs and to overcome problems such as limited solubility, drug aggregation, poor bio distribution and lack of selectivity, controlling drug release carrier and to reduce normal tissue damage. With the characteristics of nontoxic and biodegradable, it can increase the retention of drug in lesion site and the permeability, improve the concentration of the drug in lesion site. at present, there are some kinds of DDS using at test phase, such as slow controlled release drug delivery system, targeted drug delivery systems, transdermal drug delivery system, adhesion dosing system and so on. This paper makes a review for DDS.

  7. IGF system targeted therapy: Therapeutic opportunities for ovarian cancer.

    Science.gov (United States)

    Liefers-Visser, J A L; Meijering, R A M; Reyners, A K L; van der Zee, A G J; de Jong, S

    2017-11-01

    The insulin-like growth factor (IGF) system comprises multiple growth factor receptors, including insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (IR) -A and -B. These receptors are activated upon binding to their respective growth factor ligands, IGF-I, IGF-II and insulin, and play an important role in development, maintenance, progression, survival and chemotherapeutic response of ovarian cancer. In many pre-clinical studies anti-IGF-1R/IR targeted strategies proved effective in reducing growth of ovarian cancer models. In addition, anti-IGF-1R targeted strategies potentiated the efficacy of platinum based chemotherapy. Despite the vast amount of encouraging and promising pre-clinical data, anti-IGF-1R/IR targeted strategies lacked efficacy in the clinic. The question is whether targeting the IGF-1R/IR signaling pathway still holds therapeutic potential. In this review we address the complexity of the IGF-1R/IR signaling pathway, including receptor heterodimerization within and outside the IGF system and downstream signaling. Further, we discuss the implications of this complexity on current targeted strategies and indicate therapeutic opportunities for successful targeting of the IGF-1R/IR signaling pathway in ovarian cancer. Multiple-targeted approaches circumventing bidirectional receptor tyrosine kinase (RTK) compensation and prevention of system rewiring are expected to have more therapeutic potential. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  8. Effluent Monitoring System Design for the Proton Accelerator Research Center of PEFP

    International Nuclear Information System (INIS)

    Kim, Jun Yeon; Mun, Kyeong Jun; Cho, Jang Hyung; Jo, Jeong Hee

    2010-01-01

    Since host site host site was selected Gyeong-ju city in January, 2006. we need design revision of Proton Accelerator research center to reflect on host site characteristics and several conditions. Also the IAC recommended maximization of space utilization and construction cost saving. After GA(General Arrangement) is made a decision, it is necessary to evaluate the radiation analysis of every controlled area in the proton accelerator research center such as accelerator tunnel, Klystron gallery, beam experimental hall, target rooms and ion beam application building to keep dose rate below the ALARA(As Low As Reasonably achievable) objective. Our staff has reviewed and made a shielding design of them. In this paper, According to accelerator operation mode and access conditions based on radiation analysis and shielding design, we made the exhaust system configuration of controlled area in the proton accelerator research center. Also, we installed radiation monitor and set its alarm value for each radiation area

  9. Maintenance Effectiveness and Target Observation System and its ERP Interface

    International Nuclear Information System (INIS)

    Soon, Han Seong; Kim, Gi Yong; Seo, Mi Ro; Jeong, Hun Jong; Choi, Kwang Hee; Hong, Sung Yull

    2005-01-01

    Maintenance effectiveness and target observation system (MENTOS) is a maintenance rule (MR) implementation software for plant personnel to collect, edit, store, and analyze all information required for the MR implementation. Potential users and the developers of MENTOS have decided that MENTOS is implemented in the ERP system of KHNP. This article describes MENTOS briefly and introduces the ERP interface of MENTOS

  10. [Research and application of microcontroller system for target controlled infusion].

    Science.gov (United States)

    Cheng, Yuke; Dou, Jianhong; Zhang, Xingan; Wang, Ruosong

    2005-08-01

    This paper presents a microcontroller system for target controlled infusion according to pharmacodynamic parameters of intravenous anesthetics. It can control the depth of anesthesia by adjusting the level of plasma concentrations. The system has the advantages of high precision, extending power and easy manipulation. It has been used in the clinical anesthesia.

  11. Developing conservation targets in social-ecological systems

    Directory of Open Access Journals (Sweden)

    Phillip S. Levin

    2015-12-01

    Full Text Available The development of targets is foundational in conservation. Although progress has been made in setting targets, the diverse linkages among ecological and social components make target setting for coupled social-ecological systems extremely challenging. Developing integrated social-ecological targets is difficult because it forces policy makers to consider how management actions propagate throughout social-ecological systems, and because ultimately it is society, not scientists, that defines targets. We developed an interdisciplinary approach for identifying management targets and illustrate this approach using an example motivated by Puget Sound, USA. Our approach blends ecological modeling with empirical social science to articulate trade-offs and reveal societal preferences for different social-ecological states. The framework aims to place information in the hands of decision makers and promote discussion in the appropriate forums. Our ultimate objective is to encourage the informed participation of citizens in the development of social-ecological targets that reflect their values while also protecting key ecosystem attributes.

  12. A Secure and Privacy-Preserving Targeted Ad-System

    Science.gov (United States)

    Androulaki, Elli; Bellovin, Steven M.

    Thanks to its low product-promotion cost and its efficiency, targeted online advertising has become very popular. Unfortunately, being profile-based, online advertising methods violate consumers' privacy, which has engendered resistance to the ads. However, protecting privacy through anonymity seems to encourage click-fraud. In this paper, we define consumer's privacy and present a privacy-preserving, targeted ad system (PPOAd) which is resistant towards click fraud. Our scheme is structured to provide financial incentives to all entities involved.

  13. System Center 2012 R2 Virtual Machine Manager cookbook

    CERN Document Server

    Cardoso, Edvaldo Alessandro

    2014-01-01

    This book is a step-by-step guide packed with recipes that cover architecture design and planning. The book is also full of deployment tips, techniques, and solutions. If you are a solutions architect, technical consultant, administrator, or any other virtualization enthusiast who needs to use Microsoft System Center Virtual Machine Manager in a real-world environment, then this is the book for you. We assume that you have previous experience with Windows 2012 R2 and Hyper-V.

  14. The Center-TRACON Automation System: Simulation and field testing

    Science.gov (United States)

    Denery, Dallas G.; Erzberger, Heinz

    1995-01-01

    A new concept for air traffic management in the terminal area, implemented as the Center-TRACON Automation System, has been under development at NASA Ames in a cooperative program with the FAA since 1991. The development has been strongly influenced by concurrent simulation and field site evaluations. The role of simulation and field activities in the development process will be discussed. Results of recent simulation and field tests will be presented.

  15. Space and Missile Systems Center Standard: Space Flight Pressurized Systems

    Science.gov (United States)

    2015-02-28

    as an adhesive , as dictated by the application. [4.3.3.1-2] The effects of fabrication process, temperature/humidity, load spectra, and other...5.2.1-1] System connections for incompatible propellants shall be keyed, sized, or located so that it is physically impossible to interconnect them

  16. New computer system for the Japan Tier-2 center

    CERN Multimedia

    Hiroyuki Matsunaga

    2007-01-01

    The ICEPP (International Center for Elementary Particle Physics) of the University of Tokyo has been operating an LCG Tier-2 center dedicated to the ATLAS experiment, and is going to switch over to the new production system which has been recently installed. The system will be of great help to the exciting physics analyses for coming years. The new computer system includes brand-new blade servers, RAID disks, a tape library system and Ethernet switches. The blade server is DELL PowerEdge 1955 which contains two Intel dual-core Xeon (WoodCrest) CPUs running at 3GHz, and a total of 650 servers will be used as compute nodes. Each of the RAID disks is configured to be RAID-6 with 16 Serial ATA HDDs. The equipment as well as the cooling system is placed in a new large computer room, and both are hooked up to UPS (uninterruptible power supply) units for stable operation. As a whole, the system has been built with redundant configuration in a cost-effective way. The next major upgrade will take place in thre...

  17. Accumulation of the radionuclides in a target irradiated in the reactor of tajoura nuclear research center

    International Nuclear Information System (INIS)

    Abdunnobi, A.R.; Arebi, B.

    1998-01-01

    One of the main stages of radionuclides production in reactor is the distinguishing of a regime on target irradiation in order to acquire the sufficient activity and the purity of radioisotope required. The authors have derived formula for calculating radionuclidic accumulation on a target irradiated in the reactor operating 10 hours per day, 4 days a week during 4 weeks. The results of I-131 and other radionuclide accumulation are illustrated by a tellurium target irradiation in the reactor operating continuously or with interruptions

  18. Engineering system dynamics a unified graph-centered approach

    CERN Document Server

    Brown, Forbes T

    2006-01-01

    For today's students, learning to model the dynamics of complex systems is increasingly important across nearly all engineering disciplines. First published in 2001, Forbes T. Brown's Engineering System Dynamics: A Unified Graph-Centered Approach introduced students to a unique and highly successful approach to modeling system dynamics using bond graphs. Updated with nearly one-third new material, this second edition expands this approach to an even broader range of topics. What's New in the Second Edition? In addition to new material, this edition was restructured to build students' competence in traditional linear mathematical methods before they have gone too far into the modeling that still plays a pivotal role. New topics include magnetic circuits and motors including simulation with magnetic hysteresis; extensive new material on the modeling, analysis, and simulation of distributed-parameter systems; kinetic energy in thermodynamic systems; and Lagrangian and Hamiltonian methods. MATLAB(R) figures promi...

  19. TARGET - NEW PAYMENT SYSTEM FOR THE EURO AREA

    Directory of Open Access Journals (Sweden)

    ELENA VIOLETA DRĂGOI

    2015-04-01

    Full Text Available At EU level, the funds transfer systems have undergone significant changes starting with the introduction of euro. The launch of the euro, the emergence of new technologies, introduction of financial innovations and the globalization have led to reorganization of funds transfer systems` infrastructure. The paper aims to offer an analysis of actual payment system for Euro area, a trans-European funds transfer system with gross settlement in real-time for payments in euro TARGET- to increase economical and operational efficiency of payments and also to reduce the risks in the electronic funds transfer system by creating efficient and secure payment systems.

  20. System for measuring of proton polarization in polarized target

    International Nuclear Information System (INIS)

    Derkach, A.Ya.; Lukhanin, A.A.; Karnaukhov, I.M.; Kuz'menko, V.S.; Telegin, Yu.N.; Trotsenko, V.I.; Chechetenko, V.F.

    1981-01-01

    Measurement system of proton polarization in the target, which uses the method of nuclear magnetic resonance is described. To record the signal of NMR-absorption a parallel Q-meter of voltage with analogous subtraction of resonance characteristics of measurement circuit is used. To obtain gradual sensitivity of the system to polarization state in the whole volume of the target the measurement coils is made of tape conductor. The analysis and mathematical modelling of Q-meter are carried out. Corrections for nonlinearity and dispersion are calculated. Key diagrams of the main electron blocks of Q-meter are presented. The system described operates on line with the M6000 computer. Total error of measurement of polarization value of free protons in the target does not exceed 6% [ru

  1. Radiation effects in IFMIF Li target diagnostic systems

    International Nuclear Information System (INIS)

    Molla, J.; Vila, R.; Shikama, T.; Horiike, H.; Simakov, S.; Ciotti, M.; Ibarra, A.

    2009-01-01

    Diagnostics for the lithium target will be crucial for the operation of IFMIF. Several parameters as the lithium temperature, target thickness or wave pattern must be monitored during operation. Radiation effects may produce malfunctioning in any of these diagnostics due to the exposure to high radiation fields. The main diagnostic systems proposed for the operation of IFMIF are reviewed in this paper from the point of view of radiation damage. The main tools for the assessment of the performance of these diagnostics are the neutronics calculations by using specialised codes and the information accumulated during the last decades on the radiation effects in functional materials, components and diagnostics for ITER. This analysis allows to conclude that the design of some of the diagnostic systems must be revised to assure the high availability required for the target system.

  2. Target isolation system, high power laser and laser peening method and system using same

    Science.gov (United States)

    Dane, C. Brent; Hackel, Lloyd A.; Harris, Fritz

    2007-11-06

    A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

  3. The Center for Space Telemetering and Telecommunications Systems

    Science.gov (United States)

    Horan, S.; DeLeon, P.; Borah, D.; Lyman, R.

    2003-01-01

    This report comprises the final technical report for the research grant 'Center for Space Telemetering and Telecommunications Systems' sponsored by the National Aeronautics and Space Administration's Goddard Space Flight Center. The grant activities are broken down into the following technology areas: (1) Space Protocol Testing; (2) Autonomous Reconfiguration of Ground Station Receivers; (3) Satellite Cluster Communications; and (4) Bandwidth Efficient Modulation. The grant activity produced a number of technical reports and papers that were communicated to NASA as they were generated. This final report contains the final summary papers or final technical report conclusions for each of the project areas. Additionally, the grant supported students who made progress towards their degrees while working on the research.

  4. Targeting the adventitia with intracoronary beta-radiation: comparison of two dose prescriptions and the role of centering coronary arteries

    International Nuclear Information System (INIS)

    Kaluza, Grzegorz L.; Jenkins, Todd P.; Mourtada, Firas A.; Ali, Nadir M.; Lee, David P.; Okura, Hiroyuki; Fitzgerald, Peter J.; Raizner, Albert E.

    2002-01-01

    Purpose: To compare by intravascular ultrasound (IVUS) the efficacy of delivering the prescribed dose to the adventitia between two commonly used dose prescriptions for intracoronary radiotherapy. Methods and Materials: In 59 human postangioplasty coronary vessels, one IVUS cross-section (1 mm thick) with the highest plaque burden was used for creating dose-volume histograms with different hypothetical positions of the source. Results: On average, prescription to 1 mm beyond lumen surface resulted in delivery of the prescribed dose (20 Gy ± 20%) to a higher fraction of adventitial volume than with the prescription to 2 mm from the source, with source placed in vessel center, lumen center, or in the IVUS catheter position. Source placement in the lumen center resulted in a low dose heterogeneity to the adventitia and the least dose heterogeneity to the intima. Conclusions: Prescription to 1 mm beyond lumen surface appeared more effective in delivering the prescribed dose to the adventitia than the American Association of Physicists in Medicine (AAPM) recommended prescription to 2 mm from the source center. Moreover, centering the source in the lumen provides the better balance of effective adventitial targeting and intimal dose homogeneity. Modification of the current AAPM recommendation for dose prescription for intracoronary radiotherapy should be considered

  5. Systems analysis support to the waste management technology center

    International Nuclear Information System (INIS)

    Rivera, A.L.; Osborne-Lee, I.W.; DePaoli, S.M.

    1988-01-01

    This paper describes a systems analysis concept being developed in support of waste management planning and analysis activities for Martin Marietta Energy Systems, Inc. (Energy Systems), sites. This integrated systems model serves as a focus for the accumulation and documentation of technical and economic information from current waste management practices, improved operations projects, remedial actions, and new system development activities. The approach is generic and could be applied to a larger group of sites. This integrated model is a source of technical support to waste management groups in the Energy Systems complex for integrated waste management planning and related technology assessment activities. This problem-solving methodology for low-level waste (LLW) management is being developed through the Waste Management Technology Center (WMTC) for the Low-Level Waste Disposal, Development, and Demonstration (LLWDDD) Program. In support of long-range planning activities, this capability will include the development of management support tools such as specialized systems models, data bases, and information systems. These management support tools will provide continuing support in the identification and definition of technical and economic uncertainties to be addressed by technology demonstration programs. Technical planning activities and current efforts in the development of this system analysis capability for the LLWDDD Program are presented in this paper

  6. System Engineering Processes at Kennedy Space Center for Development of SLS and Orion Launch Systems

    Science.gov (United States)

    Schafer, Eric; Stambolian, Damon; Henderson, Gena

    2013-01-01

    There are over 40 subsystems being developed for the future SLS and Orion Launch Systems at Kennedy Space Center. These subsystems are developed at the Kennedy Space Center Engineering Directorate. The Engineering Directorate at Kennedy Space Center follows a comprehensive design process which requires several different product deliverables during each phase of each of the subsystems. This Presentation describes this process with examples of where the process has been applied.

  7. System of measurement of proton polarization in a polarized target

    Energy Technology Data Exchange (ETDEWEB)

    Karnaukov, I.M.; Chechetenko, V.F.; Lukhanin, A.A.; Telegin, Y.N.; Trotsenko, V.I.

    1985-05-01

    This paper describes a nuclear magnetic resonance spectrometer with high sensitivity. The signal of NMR absorption is recorded by a Q-meter with a series circuit and a circuit for compensation of the resonance characteristic of the measuring circuit. In order to ensure uniform sensitivity of the system to the state of polarization throughout the volume of the target and to enhance the S/N ration the measuring coil is made of a flat conductor. The polarization-measuring system works on-line with an M-6000 computer. The total error of measurement of the polarization of free protons in a target with allowance for the error due to local depolarization of free protons in a target with allowance for the error due to local depolarization of the working substance under irradiation with an intense photon beam is less than or equal to 6%.

  8. Monoclonal Antibody Fragments for Targeting Therapeutics to Growth Plate Cartilage | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    Researchers at The Eunice Kennedy Shriver National Institute on Child Health and Human Development (NICHD) have discovered monoclonal antibodies that bind to matrilin-3, a protein specifically expressed in cartilage tissue, that could be used for treating or inhibiting growth plate disorders, such as a skeletal dysplasia or short stature. The monoclonal antibodies can also be used to target therapeutic agents, such as anti-arthritis agents, to cartilage tissue. NICHD seeks statements of capability or interest from parties interested in collaborative research to co-develop, evaluate, or commercialize treatment of skeletal disorders using targeting antibodies.

  9. Polymer-Based Novel Lung Targeted Delivery Systems.

    Science.gov (United States)

    Elmowafy, Enas; Osman, Rihab; Ishak, Rania A H

    2017-01-01

    Due to its unique features, the respiratory tract had received great attention as a promising non-invasive route for drug administration to achieve both local and systemic effects. Efforts spent to tailor systems able to overcome the lung defence mechanisms and biological barriers are followed in this review. Aerodynamic diameter, morphology, lung deposition and drug release profiles are the main criteria describing the selected new smart lung targeted delivery systems. Novel systems such as nanoparticles, nano-embedded-in microparticles (NEM), small microparticles (MP), large porous particles (LPP), PulmospheresTM and polymeric micelles are used to passively target different areas in the respiratory tract. The most common preparation methods are outlined in the article. Special emphasis was given to the characteristics of the polymers used to fabricate the developed systems. Efforts made to prepare systems using chitosan (CS), alginate (alg), hyaluronic acid (HA), gelatin and albumin as examples of natural polymers and poly lactic-co-glycolic acid (PLGA) and poly(Ɛ-caprolactone) (PCL) as synthetic polymers were compiled. The continuous development and work in the area of lung targeting resulted in the development of engineered smart platforms with the capability to carry small drug molecules, proteins and genes to treat a variety of local and systemic diseases. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  10. Activity of Nanobins Targeted to the Urokinase Plasminogen Activator System

    Science.gov (United States)

    Hankins, Patrick Leon

    While innovations in nanotechnology have resulted in numerous medical advancements for the treatment of cancer, there remains an urgent unmet need for safe and efficient molecular platforms that facilitate the delivery of potent therapeutics to solid tumors. Nanoscale formulations help to overcome the poor bioavailability and systemic organ toxicity associated with many small molecule drugs. Of these nanoparticle drug delivery systems, the greatest clinical successes to date have employed simple nanoscale lipid bilayer assemblies which encase large payloads of chemotherapeutic. While the nanobin platform we have developed has seen initial success through the passive accumulation into tumors, actively targeting nanobins to tumor specific antigens has the potential to increase the therapeutic index of these nanoparticle drugs. We have identified the urokinase plasminogen activator (uPA) and its cell surface bound receptor (uPAR) as ideal targets for drug delivery due to their selective overexpression in metastatic cancers and their important role in tumor progression. From a panel of monoclonal antibodies targeted to uPA and uPAR, we have selected ATN291 and ATN658 as lead candidates for nanobin targeting based on their tumor cell binding and ability to be internalized by cells. A novel method of conjugating antibodies to liposomes was developed for our nanobin platform that preserves the high binding affinity and specificity of these antibodies. We evaluated these uPA- and uPAR-targeted nanobins in several xenograft tumor models and found that they were well-tolerated over a wide range of doses and demonstrated significantly increased antitumor efficacy over untargeted nanobins in multiple tumor types. Preliminary studies suggest that uPA-targeted nanobins are readily internalized by tumor cells, and we believe this is the mechanism for their increased antitumor effect. A method for radiolabeling nanobins with gallium-67 was developed, and preliminary SPECT

  11. Targeting the orexinergic system: Mainly but not only for sleep ...

    African Journals Online (AJOL)

    Orexin receptors belong to the big family of G protein coupled receptors (GPCRs) that constitute the main targets in the modern pharmacological approaches. Although the orexinergic system is involved in a variety of processes, treating sleep-wakefulness disorders such as narcolepsy and insomnia, remains the main ...

  12. Microcomputer-aided monitor for liquid hydrogen target system

    International Nuclear Information System (INIS)

    Kitami, T.; Watanabe, K.

    1983-03-01

    A microcomputer-aided monitor for a liquid hydrogen target system has been designed and tested. Various kinds of input data such as temperature, pressure, vacuum, etc. are scanned in a given time interval. Variation with time in any four items can be displayed on CRT and, if neccessary, printed out on a sheet of recording paper. (author)

  13. Petawatt laser and target irradiation system at LLNL

    International Nuclear Information System (INIS)

    Pennington, D.M.; Perry, M.D.; Britten, J.A.; Brown, C.G.; Herman, S.; Homer, J.; Miller, J.L.; Stuart, B.C.; Tietbohl, G.; Van Lue, J.; Yanovsky, V.

    1997-01-01

    In May, 1996, we demonstrated the production over a petawatt of peak power in the Nova/Petawatt Laser Facility, generating 620 J in ∼ 430 fs. Results of the first focused irradiance tests, and recent deployment of a novel targeting system will be presented

  14. Treat-to-target in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Mosca, Marta; Boumpas, Dimitrios T; Bruce, Ian N

    2013-01-01

    on May 8, 2012 to discuss whether a treat-to-target approach could be applied in the treatment of systemic lupus erythematosus (SLE) (T2T/SLE), define a research agenda, and establish a plan for moving forward. In the present paper, observations raised at the meeting and literature data on potential...

  15. A protein in neuroblastoma could be a target of immunotoxins or immunotherapy | Center for Cancer Research

    Science.gov (United States)

    A cell surface protein, glycoprotein glypican-2 (GPC2), has been found to be an effective therapeutic target in cell cultures and mouse models that mimic childhood neuroblastoma.  The CCR scientists who made this discovery, reported July 24, 2017, in PNAS, have also produced immunotoxins and chimeric antigen receptor (CAR) T cells, a type of immunotherapy, that have shown

  16. Method for Targeted Therapeutic Delivery of Proteins into Cells | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The Protein Expression Laboratory at the National Cancer Institute in Frederick, MD is seeking statements of capability or interest from parties interested in collaborative research to further develop a platform technology for the targeted intra-cellular delivery of proteins using virus-like particles (VLPs).

  17. Ground target geolocation based on digital elevation model for airborne wide-area reconnaissance system

    Science.gov (United States)

    Qiao, Chuan; Ding, Yalin; Xu, Yongsen; Xiu, Jihong

    2018-01-01

    To obtain the geographical position of the ground target accurately, a geolocation algorithm based on the digital elevation model (DEM) is developed for an airborne wide-area reconnaissance system. According to the platform position and attitude information measured by the airborne position and orientation system and the gimbal angles information from the encoder, the line-of-sight pointing vector in the Earth-centered Earth-fixed coordinate frame is solved by the homogeneous coordinate transformation. The target longitude and latitude can be solved with the elliptical Earth model and the global DEM. The influences of the systematic error and measurement error on ground target geolocation calculation accuracy are analyzed by the Monte Carlo method. The simulation results show that this algorithm can improve the geolocation accuracy of ground target in rough terrain area obviously. The geolocation accuracy of moving ground target can be improved by moving average filtering (MAF). The validity of the geolocation algorithm is verified by the flight test in which the plane flies at a geodetic height of 15,000 m and the outer gimbal angle is <47°. The geolocation root mean square error of the target trajectory is <45 and <7 m after MAF.

  18. Preferential lentiviral targeting of astrocytes in the central nervous system.

    Directory of Open Access Journals (Sweden)

    Michael Fassler

    Full Text Available The ability to visualize and genetically manipulate specific cell populations of the central nervous system (CNS is fundamental to a better understanding of brain functions at the cellular and molecular levels. Tools to selectively target cells of the CNS include molecular genetics, imaging, and use of transgenic animals. However, these approaches are technically challenging, time consuming, and difficult to control. Viral-mediated targeting of cells in the CNS can be highly beneficial for studying and treating neurodegenerative diseases. Yet, despite specific marking of numerous cell types in the CNS, in vivo selective targeting of astrocytes has not been optimized. In this study, preferential targeting of astrocytes in the CNS was demonstrated using engineered lentiviruses that were pseudotyped with a modified Sindbis envelope and displayed anti-GLAST IgG on their surfaces as an attachment moiety. Viral tropism for astrocytes was initially verified in vitro in primary mixed glia cultures. When injected into the brains of mice, lentiviruses that displayed GLAST IgG on their surface, exhibited preferential astrocyte targeting, compared to pseudotyped lentiviruses that did not incorporate any IgG or that expressed a control isotype IgG. Overall, this approach is highly flexible and can be exploited to selectively target astrocytes or other cell types of the CNS. As such, it can open a window to visualize and genetically manipulate astrocytes or other cells of the CNS as means of research and treatment.

  19. Thermal hydraulics of accelerator driven system windowless targets

    Directory of Open Access Journals (Sweden)

    Bruno ePanella

    2015-07-01

    Full Text Available The study of the fluid dynamics of the windowless spallation target of an Accelerator Driven System (ADS is presented. Several target mockup configurations have been investigated: the first one was a symmetrical target, that was made by two concentric cylinders, the other configurations are not symmetrical. In the experiments water has been used as hydraulic equivalent to lead-bismuth eutectic fluid. The experiments have been carried out at room temperature and flow rate up to 24 kg/s. The fluid velocity components have been measured by an ultrasound technique. The velocity field of the liquid within the target region either for the approximately axial-symmetrical configuration or for the not symmetrical ones as a function of the flow rate and the initial liquid level is presented. A comparison of experimental data with the prediction of the finite volume FLUENT code is also presented. Moreover the results of a 2D-3D numerical analysis that investigates the effect on the steady state thermal and flow fields due to the insertion of guide vanes in the windowless target unit of the EFIT project ADS nuclear reactor are presented, by analysing both the cold flow case (absence of power generation and the hot flow case (nominal power generation inside the target unit.

  20. New data acquisition system for the lujan center

    International Nuclear Information System (INIS)

    Nelson, R.; Bowling, P.S.; Cooper, G.M.; Kozlowski, T.

    2001-01-01

    To meet the data acquisition requirements for six new neutron scattering instruments at the Los Alamos Science Center (LANSCE), we are building systems using Web tools, commercial hardware and software, software developed by the controls community, and custom hardware developed by the neutron scattering community. To service these new instruments as well as seven existing instruments, our data acquisition system needs common software and hardware core capabilities and the means to flexibly integrate them while differentiating the needs of the diverse instrument suite. Neutron events are captured and processed in VXI modules while controls for sample environment and beam line setup are processed with PCs. Typically users access the system through web browsers. (author)

  1. Neuromorphic cognitive systems a learning and memory centered approach

    CERN Document Server

    Yu, Qiang; Hu, Jun; Tan Chen, Kay

    2017-01-01

    This book presents neuromorphic cognitive systems from a learning and memory-centered perspective. It illustrates how to build a system network of neurons to perform spike-based information processing, computing, and high-level cognitive tasks. It is beneficial to a wide spectrum of readers, including undergraduate and postgraduate students and researchers who are interested in neuromorphic computing and neuromorphic engineering, as well as engineers and professionals in industry who are involved in the design and applications of neuromorphic cognitive systems, neuromorphic sensors and processors, and cognitive robotics. The book formulates a systematic framework, from the basic mathematical and computational methods in spike-based neural encoding, learning in both single and multi-layered networks, to a near cognitive level composed of memory and cognition. Since the mechanisms for integrating spiking neurons integrate to formulate cognitive functions as in the brain are little understood, studies of neuromo...

  2. CCSDS telemetry systems experience at the Goddard Space Flight Center

    Science.gov (United States)

    Carper, Richard D.; Stallings, William H., III

    1990-01-01

    NASA Goddard Space Flight Center (GSFC) designs, builds, manages, and operates science and applications spacecraft in near-earth orbit, and provides data capture, data processing, and flight control services for these spacecraft. In addition, GSFC has the responsibility of providing space-ground and ground-ground communications for near-earth orbiting spacecraft, including those of the manned spaceflight programs. The goal of reducing both the developmental and operating costs of the end-to-end information system has led the GSFC to support and participate in the standardization activities of the Consultative Committee for Space Data Systems (CCSDS), including those for packet telemetry. The environment in which such systems function is described, and the GSFC experience with CCSDS packet telemetry in the context of the Gamma-Ray Observatory project is discussed.

  3. New data acquisition system for the lujan center

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, R.; Bowling, P.S.; Cooper, G.M.; Kozlowski, T. [Los Alamos National Loboratory, Los Alamos, NM (United States)

    2001-03-01

    To meet the data acquisition requirements for six new neutron scattering instruments at the Los Alamos Science Center (LANSCE), we are building systems using Web tools, commercial hardware and software, software developed by the controls community, and custom hardware developed by the neutron scattering community. To service these new instruments as well as seven existing instruments, our data acquisition system needs common software and hardware core capabilities and the means to flexibly integrate them while differentiating the needs of the diverse instrument suite. Neutron events are captured and processed in VXI modules while controls for sample environment and beam line setup are processed with PCs. Typically users access the system through web browsers. (author)

  4. A person-centered intervention targeting the psychosocial needs of gynecological cancer survivors

    DEFF Research Database (Denmark)

    Olesen, Mette Linnet; Duun-Henriksen, Anne Katrine; Hansson, Eva Helena

    2016-01-01

    , depression, self-esteem, and self-reported ability to monitor and respond to symptoms of recurrence. METHODS: We randomly assigned 165 gynecological cancer survivors to usual care (UC) plus GSD-GYN-C or UC alone. Self-reported QOL-cancer survivor (QOL-CS) total score and subscale scores on physical......PURPOSE: We investigated the effect of a person-centered intervention consisting of two to four nurse-led conversations using guided self-determination tailored to gynecologic cancer (GSD-GYN-C) on gynecological cancer survivors' quality of life (QOL), impact of cancer, distress, anxiety...... and control groups after baseline adjustment. CONCLUSION: We observed higher physical well-being 9 months after randomization in the GSD-GYN-C group, as compared to women receiving usual care. IMPLICATIONS FOR CANCER SURVIVORS: The results suggest that the person-centered intervention GSD-GYN-C may improve...

  5. Multi-Stage System for Automatic Target Recognition

    Science.gov (United States)

    Chao, Tien-Hsin; Lu, Thomas T.; Ye, David; Edens, Weston; Johnson, Oliver

    2010-01-01

    A multi-stage automated target recognition (ATR) system has been designed to perform computer vision tasks with adequate proficiency in mimicking human vision. The system is able to detect, identify, and track targets of interest. Potential regions of interest (ROIs) are first identified by the detection stage using an Optimum Trade-off Maximum Average Correlation Height (OT-MACH) filter combined with a wavelet transform. False positives are then eliminated by the verification stage using feature extraction methods in conjunction with neural networks. Feature extraction transforms the ROIs using filtering and binning algorithms to create feature vectors. A feedforward back-propagation neural network (NN) is then trained to classify each feature vector and to remove false positives. The system parameter optimizations process has been developed to adapt to various targets and datasets. The objective was to design an efficient computer vision system that can learn to detect multiple targets in large images with unknown backgrounds. Because the target size is small relative to the image size in this problem, there are many regions of the image that could potentially contain the target. A cursory analysis of every region can be computationally efficient, but may yield too many false positives. On the other hand, a detailed analysis of every region can yield better results, but may be computationally inefficient. The multi-stage ATR system was designed to achieve an optimal balance between accuracy and computational efficiency by incorporating both models. The detection stage first identifies potential ROIs where the target may be present by performing a fast Fourier domain OT-MACH filter-based correlation. Because threshold for this stage is chosen with the goal of detecting all true positives, a number of false positives are also detected as ROIs. The verification stage then transforms the regions of interest into feature space, and eliminates false positives using an

  6. Ex vivo investigation of magnetically targeted drug delivery system

    International Nuclear Information System (INIS)

    Yoshida, Y.; Fukui, S.; Fujimoto, S.; Mishima, F.; Takeda, S.; Izumi, Y.; Ohtani, S.; Fujitani, Y.; Nishijima, S.

    2007-01-01

    In conventional systemic drug delivery the drug is administered by intravenous injection; it then travels to the heart from where it is pumped to all regions of the body. When the drug is aimed at a small target region, this method is extremely inefficient and leads to require much larger doses than those being necessary. In order to overcome this problem a number of targeted drug delivery methods are developed. One of these, magnetically targeted drug delivery system (MT-DDS) will be a promising way, which involves binding a drug to small biocompatible magnetic particles, injecting these into the blood stream and using a high gradient magnetic field to pull them out of suspension in the target region. In the present paper, we describe an ex vivo experimental work. It is also reported that navigation and accumulation test of the magnetic particles in the Y-shaped glass tube was performed in order to examine the threshold of the magnetic force for accumulation. It is found that accumulation of the magnetic particles was succeeded in the blood vessel when a permanent magnet was placed at the vicinity of the blood vessel. This result indicates the feasibility of the magnetically drug targeting in the blood vessel

  7. System Engineering Processes at Kennedy Space Center for Development of the SLS and Orion Launch Systems

    Science.gov (United States)

    Schafer, Eric J.

    2012-01-01

    There are over 40 subsystems being developed for the future SLS and Orion Launch Systems at Kennedy Space Center. These subsystems developed at the Kennedy Space Center Engineering Directorate follow a comprehensive design process which requires several different product deliverables during each phase of each of the subsystems. This Paper describes this process and gives an example of where the process has been applied.

  8. Assessment center energy collector system of crude Puerto Escondido

    International Nuclear Information System (INIS)

    Rodríguez Sosa, Yadier; Morón Álvarez, Carlos J.; Gozá León, Osvaldo

    2015-01-01

    In this paper the results of the evaluation of the energy system Collector Crude Center of Puerto Escondido in the first half of 2014. By implementing the overall strategy presented Process Analysis developed and implemented an energy assessment procedure allowed characterize current plant conditions, and raise a number of measures and recommendations that lead to improved energy use and reduced environmental impact. It also presents the computational tools used for both process simulation (Hysys v 3.2) as for technical analysis - economic and environmental (Microsoft Excel). (full text)

  9. Treat-to-target in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Mosca, Marta; Boumpas, Dimitrios T; Bruce, Ian N

    2013-01-01

    Multiple clinical trials performed over twenty years in the treatment of rheumatoid arthritis (RA) have clearly demonstrated that patients have better outcomes if their disease activity at each time-point for follow-up includes a pre-specified target. A European SLE expert panel met in Zurich...... on May 8, 2012 to discuss whether a treat-to-target approach could be applied in the treatment of systemic lupus erythematosus (SLE) (T2T/SLE), define a research agenda, and establish a plan for moving forward. In the present paper, observations raised at the meeting and literature data on potential...

  10. A simplified regimen of targeted antifungal prophylaxis in liver transplant recipients: A single-center experience.

    Science.gov (United States)

    Lavezzo, B; Patrono, D; Tandoi, F; Martini, S; Fop, F; Ballerini, V; Stratta, C; Skurzak, S; Lupo, F; Strignano, P; Donadio, P P; Salizzoni, M; Romagnoli, R; De Rosa, F G

    2018-04-01

    Invasive fungal infection (IFI) is a severe complication of liver transplantation burdened by high mortality. Guidelines recommend targeted rather than universal antifungal prophylaxis based on tiers of risk. We aimed to evaluate IFI incidence, risk factors, and outcome after implementation of a simplified two-tiered targeted prophylaxis regimen based on a single broad-spectrum antifungal drug (amphotericin B). Patients presenting 1 or more risk factors according to literature were administered prophylaxis. Prospectively collected data on all adult patients transplanted in Turin from January 2011 to December 2015 were reviewed. Patients re-transplanted before postoperative day 7 were considered once, yielding a study cohort of 581 cases. Prophylaxis was administered to 299 (51.4%) patients; adherence to protocol was 94.1%. Sixteen patients developed 18 IFIs for an overall rate of 2.8%. All IFI cases were in targeted prophylaxis group; none of the non-prophylaxis group developed IFI. Most cases (81.3%) presented within 30 days after transplantation during prophylaxis; predominant pathogens were molds (94.4%). Only 1 case of candidemia was observed. One-year mortality in IFI patients was 33.3% vs 6.4% in patients without IFI (P = .001); IFI attributable mortality was 6.3%. At multivariate analysis, significant risk factors for IFI were renal replacement therapy (OR = 8.1) and re-operation (OR = 5.2). The implementation of a simplified targeted prophylaxis regimen appeared to be safe and applicable and was associated with low IFI incidence and mortality. Association of IFI with re-operation and renal replacement therapy calls for further studies to identify optimal prophylaxis in this subset of patients. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences

    Directory of Open Access Journals (Sweden)

    Wolfram Malter

    2014-01-01

    Full Text Available Breast-conserving surgery followed by whole-breast irradiation is the standard local therapy for early breast cancer. The international discussion of reduced importance of wider tumor-free resection margins than “tumor not touching ink” leads to the development of five principles in targeted oncoplastic breast surgery. IORT improves local recurrence risk and diminishes toxicity since there is less irradiation of healthy tissue. Intraoperative radiotherapy (IORT can be delivered in two settings: an IORT boost followed by a conventional regimen of external beam radiotherapy or a single IORT dose. The data from TARGIT-A and ELIOT reinforce the conviction that intraoperative radiotherapy during breast-conserving surgery is a reliable alternative to conventional postoperative fractionated irradiation, but only in a carefully selected population at low risk of local recurrence. We describe our experiences with IORT boost (50 kV energy X-rays; 20 Gy in combination with targeted oncoplastic breast surgery in a routine clinical setting. Our experiences demonstrate the applicability and reliability of combining IORT boost with targeted oncoplastic breast surgery in breast-conserving therapy of early breast cancer.

  12. Heat-pump-centered integrated community energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Schaetzle, W.J.; Brett, C.E.; Seppanen, M.S.

    1979-12-01

    The heat-pump-centered integrated community energy system (HP-ICES) supplies district heating and cooling using heat pumps and a thermal energy storage system which is provided by nature in underground porous formations filled with water, i.e., aquifers. The energy is transported by a two-pipe system, one for warm water and one for cool water, between the aquifers and the controlled environments. Each energy module contains the controlled environments, an aquifer, wells for access to the aquifer, the two pipe water distribution system and water source heat pumps. The heat pumps upgrade the energy in the distribution system for use in the controlled environments. Economically, the system shows improvement on both energy usage and capital costs. The system saves over 60% of the energy required for resistance heating; saves over 30% of the energy required for most air-source heat pumps and saves over 60% of the energy required for gas, coal, or oil heating, when comparing to energy input required at the power plant for heat pump usage. The proposed system has been analyzed as demonstration projects for a downtown portion of Louisville, Kentucky, and a section of Fort Rucker, Alabama. The downtown Louisville demonstration project is tied directly to major buildings while the Fort Rucker demonstration project is tied to a dispersed subdivision of homes. The Louisville project shows a payback of approximately 3 y, while Fort Rucker is approximately 30 y. The primary difference is that at Fort Rucker new heat pumps are charged to the system. In Louisville, either new construction requiring heating and cooling systems or existing chillers are utilized. (LCL)

  13. Neural Network Target Identification System for False Alarm Reduction

    Science.gov (United States)

    Ye, David; Edens, Weston; Lu, Thomas T.; Chao, Tien-Hsin

    2009-01-01

    A multi-stage automated target recognition (ATR) system has been designed to perform computer vision tasks with adequate proficiency in mimicking human vision. The system is able to detect, identify, and track targets of interest. Potential regions of interest (ROIs) are first identified by the detection stage using an Optimum Trade-off Maximum Average Correlation Height (OT-MACH) filter combined with a wavelet transform. False positives are then eliminated by the verification stage using feature extraction methods in conjunction with neural networks. Feature extraction transforms the ROIs using filtering and binning algorithms to create feature vectors. A feed forward back propagation neural network (NN) is then trained to classify each feature vector and remove false positives. This paper discusses the test of the system performance and parameter optimizations process which adapts the system to various targets and datasets. The test results show that the system was successful in substantially reducing the false positive rate when tested on a sonar image dataset.

  14. Analysis of an XADS Target with the System Code TRACE

    International Nuclear Information System (INIS)

    Jaeger, Wadim; Sanchez Espinoza, Victor H.; Feng, Bo

    2008-01-01

    Accelerator-driven systems (ADS) present an option to reduce the radioactive waste of the nuclear industry. The experimental Accelerator-Driven System (XADS) has been designed to investigate the feasibility of using ADS on an industrial scale to burn minor actinides. The target section lies in the middle of the subcritical core and is bombarded by a proton beam to produce spallation neutrons. The thermal energy produced from this reaction requires a heat removal system for the target section. The target is cooled by liquid lead-bismuth-eutectics (LBE) in the primary system which in turn transfers the heat via a heat exchanger (HX) to the secondary coolant, Diphyl THT (DTHT), a synthetic diathermic fluid. Since this design is still in development, a detailed investigation of the system is necessary to evaluate the behavior during normal and transient operations. Due to the lack of experimental facilities and data for ADS, the analyses are mostly done using thermal hydraulic codes. In addition to evaluating the thermal hydraulics of the XADS, this paper also benchmarks a new code developed by the NRC, TRACE, against other established codes. The events used in this study are beam power switch-on/off transients and a loss of heat sink accident. The obtained results from TRACE were in good agreement with the results of various other codes. (authors)

  15. Model-Based Systems Engineering in Concurrent Engineering Centers

    Science.gov (United States)

    Iwata, Curtis; Infeld, Samantha; Bracken, Jennifer Medlin; McGuire, Melissa; McQuirk, Christina; Kisdi, Aron; Murphy, Jonathan; Cole, Bjorn; Zarifian, Pezhman

    2015-01-01

    Concurrent Engineering Centers (CECs) are specialized facilities with a goal of generating and maturing engineering designs by enabling rapid design iterations. This is accomplished by co-locating a team of experts (either physically or virtually) in a room with a narrow design goal and a limited timeline of a week or less. The systems engineer uses a model of the system to capture the relevant interfaces and manage the overall architecture. A single model that integrates other design information and modeling allows the entire team to visualize the concurrent activity and identify conflicts more efficiently, potentially resulting in a systems model that will continue to be used throughout the project lifecycle. Performing systems engineering using such a system model is the definition of model-based systems engineering (MBSE); therefore, CECs evolving their approach to incorporate advances in MBSE are more successful in reducing time and cost needed to meet study goals. This paper surveys space mission CECs that are in the middle of this evolution, and the authors share their experiences in order to promote discussion within the community.

  16. Exploding pusher targets for the SHIVA laser system

    International Nuclear Information System (INIS)

    Rosen, M.D.; Larsen, J.T.; Nuckolls, J.H.

    1977-01-01

    The first targets for the 20 TW SHIVA laser system were designed. They are simple glass micro-balloons, approximately 300 μm in diameter and 2 μm thick, filled with D-T gas. Using LASNEX, whose model physics was utilized successfully for ARGUS targets, we optimize for both gain and yield. The target behaves as an exploding pusher. Different simple analytic models for the physics of this mode are presented, and are tested by comparing their scaling predictions, at constant absorbed power, with those demonstrated by LASNEX. Emphasis is placed on successful prediction of the basic quantities of peak ion temperature and compression, rather than neutron yield or n tau

  17. Quality management system of Saraykoy Nuclear Research and Training center

    International Nuclear Information System (INIS)

    Gurellier, R.; Akchay, S.; Zararsiz, S.

    2014-01-01

    Full text : Technical competence and national/international acceptance of independency of laboratories is ensured by going through accreditations. It provides decreasing the risk of a slowdown in international trade due to unnecessary repetition of testing and analyses. It also eliminates the cost of additional experiments and analyses. Saraykoy Nuclear Research and Training Center (SANAEM) has performed intensive studies to establish an effective and well-functioning QMS (Quality Management System) by full accordance with the requirements of ISO/IEC 17025, since the begining of 2006. Laboratories, especially serving to public health studies and important trade duties require urgent accreditation. In this regard, SANAEM has established a quality management system and performed accreditation studies

  18. Implementation of a virtual link between power system testbeds at Marshall Spaceflight Center and Lewis Research Center

    Science.gov (United States)

    Doreswamy, Rajiv

    1990-01-01

    The Marshall Space Flight Center (MSFC) owns and operates a space station module power management and distribution (SSM-PMAD) testbed. This system, managed by expert systems, is used to analyze and develop power system automation techniques for Space Station Freedom. The Lewis Research Center (LeRC), Cleveland, Ohio, has developed and implemented a space station electrical power system (EPS) testbed. This system and its power management controller are representative of the overall Space Station Freedom power system. A virtual link is being implemented between the testbeds at MSFC and LeRC. This link would enable configuration of SSM-PMAD as a load center for the EPS testbed at LeRC. This connection will add to the versatility of both systems, and provide an environment of enhanced realism for operation of both testbeds.

  19. Development of a computer system at La Hague center

    International Nuclear Information System (INIS)

    Mimaud, Robert; Malet, Georges; Ollivier, Francis; Fabre, J.-C.; Valois, Philippe; Desgranges, Patrick; Anfossi, Gilbert; Gentizon, Michel; Serpollet, Roger.

    1977-01-01

    The U.P.2 plant, built at La Hague Center is intended mainly for the reprocessing of spent fuels coming from (as metal) graphite-gas reactors and (as oxide) light-water, heavy-water and breeder reactors. In each of the five large nuclear units the digital processing of measurements was dealt with until 1974 by CAE 3030 data processors. During the period 1974-1975 a modern industrial computer system was set up. This system, equipped with T 2000/20 material from the Telemecanique company, consists of five measurement acquisition devices (for a total of 1500 lines processed) and two central processing units (CPU). The connection of these two PCU (Hardware and Software) enables an automatic connection of the system either on the first CPU or on the second one. The system covers, at present, data processing, threshold monitoring, alarm systems, display devices, periodical listing, and specific calculations concerning the process (balances etc), and at a later stage, an automatic control of certain units of the Process [fr

  20. Emerging drugs which target the renin-angiotensin-aldosterone system.

    Science.gov (United States)

    Steckelings, Ulrike Muscha; Paulis, Ludovit; Unger, Thomas; Bader, Michael

    2011-12-01

    The renin-angiotensin-aldosterone system (RAAS) is already the most important target for drugs in the cardiovascular system. However, still new developments are underway to interfere with the system on different levels. The novel strategies to interfere with RAAS aim to reduce the synthesis of the two major RAAS effector hormones, angiotensin (Ang) II and aldosterone, or interfere with their receptors, AT1 and mineralocorticoid receptor, respectively. Moreover, novel targets have been identified in RAAS, such as the (pro)renin receptor, and molecules, which counteract the classical actions of Ang II and are therefore beneficial in cardiovascular diseases. These include the AT2 receptor and the ACE2/Ang-(1-7)/Mas axis. The search for drugs activating these tissue-protective arms of RAAS is therefore the most innovative field in RAAS pharmacology. Most of the novel pharmacological strategies to inhibit the classical RAAS need to prove their superiority above the existing treatment in clinical trials and then have to compete against these now quite cheap drugs in a competitive market. The newly discovered targets have functions beyond the cardiovascular system opening up novel therapeutic areas for drugs interfering with RAAS components.

  1. IFMIF-CDA technical workshop on lithium target system. Proceedings

    International Nuclear Information System (INIS)

    1995-09-01

    An intense neutron source, International Fusion Materials Irradiation Facility (IFMIF) is planned under the collaborative program by International Energy Agency (IEA), and the Conceptual Design Activity (CDA) started in February 1995. US, Japan and EU are responsible to take a lead in coordinating accelerator, target and test cell design, respectively. In order to exchange the current results of the study and to coordinate the activities for the design integration, the first technical workshop on the lithium target system was held in the period of July 18-21 at the Tokai Research Establishment of the JAERI. This publication summarizes the materials presented in this meeting. The presentations and discussions were organized with the identified CDA tasks. It was confirmed that the reference design of the IFMIF target based on the previous studies under FMIT and ESNIT, elaborated to meet IFMIF parameters, is reasonable and feasible. It was pointed out that the interface between accelerator and test cell subsystems should be carefully investigated to avoid technical conflicts. Some design options such as nozzle, backwall and lithium jet geometry, lithium purity control, and lithium vapor control, based on the current technology were proposed to improve the integral target system function, and further R and D studies were suggested for design integration. (author)

  2. Constraints in distortion-invariant target recognition system simulation

    Science.gov (United States)

    Iftekharuddin, Khan M.; Razzaque, Md A.

    2000-11-01

    Automatic target recognition (ATR) is a mature but active research area. In an earlier paper, we proposed a novel ATR approach for recognition of targets varying in fine details, rotation, and translation using a Learning Vector Quantization (LVQ) Neural Network (NN). The proposed approach performed segmentation of multiple objects and the identification of the objects using LVQNN. In this current paper, we extend the previous approach for recognition of targets varying in rotation, translation, scale, and combination of all three distortions. We obtain the analytical results of the system level design to show that the approach performs well with some constraints. The first constraint determines the size of the input images and input filters. The second constraint shows the limits on amount of rotation, translation, and scale of input objects. We present the simulation verification of the constraints using DARPA's Moving and Stationary Target Recognition (MSTAR) images with different depression and pose angles. The simulation results using MSTAR images verify the analytical constraints of the system level design.

  3. Research on Key Technologies of Network Centric System Distributed Target Track Fusion

    Directory of Open Access Journals (Sweden)

    Yi Mao

    2017-01-01

    Full Text Available To realize common tactical picture in network-centered system, this paper proposes a layered architecture for distributed information processing and a method for distributed track fusion on the basis of analyzing the characteristics of network-centered systems. Basing on the noncorrelation of three-dimensional measurement of surveillance and reconnaissance sensors under polar coordinates, it also puts forward an algorithm for evaluating track quality (TQ using statistical decision theory. According to simulation results, the TQ value is associated with the measurement accuracy of sensors and the motion state of targets, which is well matched with the convergence process of tracking filters. Besides, the proposed algorithm has good reliability and timeliness in track quality evaluation.

  4. Center for Advanced Biofuel Systems (CABS) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Kutchan, Toni M. [Donald Danforth Plant Science Center, St. Louis, MO (United States)

    2015-12-02

    One of the great challenges facing current and future generations is how to meet growing energy demands in an environmentally sustainable manner. Renewable energy sources, including wind, geothermal, solar, hydroelectric, and biofuel energy systems, are rapidly being developed as sustainable alternatives to fossil fuels. Biofuels are particularly attractive to the U.S., given its vast agricultural resources. The first generation of biofuel systems was based on fermentation of sugars to produce ethanol, typically from food crops. Subsequent generations of biofuel systems, including those included in the CABS project, will build upon the experiences learned from those early research results and will have improved production efficiencies, reduced environmental impacts and decreased reliance on food crops. Thermodynamic models predict that the next generations of biofuel systems will yield three- to five-fold more recoverable energy products. To address the technological challenges necessary to develop enhanced biofuel systems, greater understanding of the non-equilibrium processes involved in solar energy conversion and the channeling of reduced carbon into biofuel products must be developed. The objective of the proposed Center for Advanced Biofuel Systems (CABS) was to increase the thermodynamic and kinetic efficiency of select plant- and algal-based fuel production systems using rational metabolic engineering approaches grounded in modern systems biology. The overall strategy was to increase the efficiency of solar energy conversion into oils and other specialty biofuel components by channeling metabolic flux toward products using advanced catalysts and sensible design:1) employing novel protein catalysts that increase the thermodynamic and kinetic efficiencies of photosynthesis and oil biosynthesis; 2) engineering metabolic networks to enhance acetyl-CoA production and its channeling towards lipid synthesis; and 3) engineering new metabolic networks for the

  5. T Cells that Recognize HPV Protein Can Target Virus-Infected Cells | Center for Cancer Research

    Science.gov (United States)

    Adoptive T-cell transfer (ACT) is a promising form of cancer immunotherapy. Treating patients with T cells isolated from a tumor and subsequently expanded in the lab can cause the complete regression of some melanomas and cervical cancers, but the treatment is currently restricted to a few cancer types. An approach that may be applied to a wider array of cancers involves modifying peripheral blood T cells with chimeric antigen receptors or T-cell receptors (TCR) that target specific tumor antigens. Unfortunately, epithelial cancers, which are the vast majority of cancers diagnosed, have proven difficult to treat this way because most identified antigens are shared with healthy tissues and targeting them leads to toxic side effects. However, cancers caused by persistent human papillomavirus (HPV) infection, including cervical, head and neck, anal, vaginal, vulvar, and penile cancers, may be particularly amenable to the latter form of ACT since the E6 and E7 viral proteins are essential for cancer formation but are not produced in normal tissues. To test this idea, Christian Hinrichs, M.D., and his colleagues examined tumor infiltrating lymphocytes (TILs) from a patient who experienced a prolonged disease-free period after her second surgical removal of metastatic anal cancer in the hopes of identifying a TCR against one of the HPV oncoproteins.

  6. Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?

    Science.gov (United States)

    Stevens, A M

    2006-01-01

    During pregnancy maternal and fetal cells commute back and forth leading to fetal microchimerism in the mother and maternal microchimerism in the child that can persist for years after the birth. Chimeric fetal and maternal cells can be hematopoietic or can differentiate into somatic cells in multiple organs, potentially acting as targets for 'autoimmunity' and so have been implicated in the pathogenesis of autoimmune diseases that resemble graft-versus-host disease after stem cell transplantation. Fetal cells have been found in women with systemic lupus erythematosus, both in the blood and a target organ, the kidney, suggesting that they may be involved in pathogenesis. Future studies will address how the host immune system normally tolerates maternal and fetal cells or how the balance may change during autoimmunity.

  7. Cnidarian Neurotoxic Peptides Affecting Central Nervous System Targets.

    Science.gov (United States)

    Lazcano-Pérez, Fernando; Hernández-Guzmán, Ulises; Sánchez-Rodríguez, Judith; Arreguín-Espinosa, Roberto

    2016-01-01

    Natural products from animal venoms have been used widely in the discovery of novel molecules with particular biological activities that enable their use as potential drug candidates. The phylum Cnidaria (jellyfish, sea anemones, corals zoanthids, hydrozoans, etc.) is the most ancient venomous phylum on earth. Its venoms are composed of a complex mixture of peptidic compounds with neurotoxic and cytolitic properties that have shown activity on mammalian systems despite the fact that they are naturally targeted against fish and invertebrate preys, mainly crustaceans. For this reason, cnidarian venoms are an interesting and vast source of molecules with a remarkable activity on central nervous system, targeting mainly voltage-gated ion channels, ASIC channels, and TRPV1 receptors. In this brief review, we list the amino acid sequences of most cnidarian neurotoxic peptides reported to date. Additionally, we propose the inclusion of a new type of voltage-gated sea anemone sodium channel toxins based on the most recent reports.

  8. Information System Success Model for Customer Relationship Management System in Health Promotion Centers

    Science.gov (United States)

    Choi, Wona; Rho, Mi Jung; Park, Jiyun; Kim, Kwang-Jum; Kwon, Young Dae

    2013-01-01

    Objectives Intensified competitiveness in the healthcare industry has increased the number of healthcare centers and propelled the introduction of customer relationship management (CRM) systems to meet diverse customer demands. This study aimed to develop the information system success model of the CRM system by investigating previously proposed indicators within the model. Methods The evaluation areas of the CRM system includes three areas: the system characteristics area (system quality, information quality, and service quality), the user area (perceived usefulness and user satisfaction), and the performance area (personal performance and organizational performance). Detailed evaluation criteria of the three areas were developed, and its validity was verified by a survey administered to CRM system users in 13 nationwide health promotion centers. The survey data were analyzed by the structural equation modeling method, and the results confirmed that the model is feasible. Results Information quality and service quality showed a statistically significant relationship with perceived usefulness and user satisfaction. Consequently, the perceived usefulness and user satisfaction had significant influence on individual performance as well as an indirect influence on organizational performance. Conclusions This study extends the research area on information success from general information systems to CRM systems in health promotion centers applying a previous information success model. This lays a foundation for evaluating health promotion center systems and provides a useful guide for successful implementation of hospital CRM systems. PMID:23882416

  9. Information system success model for customer relationship management system in health promotion centers.

    Science.gov (United States)

    Choi, Wona; Rho, Mi Jung; Park, Jiyun; Kim, Kwang-Jum; Kwon, Young Dae; Choi, In Young

    2013-06-01

    Intensified competitiveness in the healthcare industry has increased the number of healthcare centers and propelled the introduction of customer relationship management (CRM) systems to meet diverse customer demands. This study aimed to develop the information system success model of the CRM system by investigating previously proposed indicators within the model. THE EVALUATION AREAS OF THE CRM SYSTEM INCLUDES THREE AREAS: the system characteristics area (system quality, information quality, and service quality), the user area (perceived usefulness and user satisfaction), and the performance area (personal performance and organizational performance). Detailed evaluation criteria of the three areas were developed, and its validity was verified by a survey administered to CRM system users in 13 nationwide health promotion centers. The survey data were analyzed by the structural equation modeling method, and the results confirmed that the model is feasible. Information quality and service quality showed a statistically significant relationship with perceived usefulness and user satisfaction. Consequently, the perceived usefulness and user satisfaction had significant influence on individual performance as well as an indirect influence on organizational performance. This study extends the research area on information success from general information systems to CRM systems in health promotion centers applying a previous information success model. This lays a foundation for evaluating health promotion center systems and provides a useful guide for successful implementation of hospital CRM systems.

  10. Development of a component centered fault monitoring and diagnosis knowledge based system for space power system

    Science.gov (United States)

    Lee, S. C.; Lollar, Louis F.

    1988-01-01

    The overall approach currently being taken in the development of AMPERES (Autonomously Managed Power System Extendable Real-time Expert System), a knowledge-based expert system for fault monitoring and diagnosis of space power systems, is discussed. The system architecture, knowledge representation, and fault monitoring and diagnosis strategy are examined. A 'component-centered' approach developed in this project is described. Critical issues requiring further study are identified.

  11. Magnetron co-sputtering system for coating ICF targets

    International Nuclear Information System (INIS)

    Hsieh, E.J.; Meyer, S.F.; Halsey, W.G.; Jameson, G.T.; Wittmayer, F.J.

    1981-01-01

    Fabrication of Inertial Confinement Fusion (ICF) targets requires deposition of various types of coatings on microspheres. The mechanical strength, and surface finish of the coatings are of concern in ICF experiments. The tensile strength of coatings can be controlled through grain refinement, selective doping and alloy formation. We have constructed a magnetron co-sputtering system to produce variable density profile coatings with high tensile strength on microspheres

  12. Design and implementation of typical target image database system

    International Nuclear Information System (INIS)

    Qin Kai; Zhao Yingjun

    2010-01-01

    It is necessary to provide essential background data and thematic data timely in image processing and application. In fact, application is an integrating and analyzing procedure with different kinds of data. In this paper, the authors describe an image database system which classifies, stores, manages and analyzes database of different types, such as image database, vector database, spatial database, spatial target characteristics database, its design and structure. (authors)

  13. Operating The Central Process Systems At Glenn Research Center

    Science.gov (United States)

    Weiler, Carly P.

    2004-01-01

    As a research facility, the Glenn Research Center (GRC) trusts and expects all the systems, controlling their facilities to run properly and efficiently in order for their research and operations to occur proficiently and on time. While there are many systems necessary for the operations at GRC, one of those most vital systems is the Central Process Systems (CPS). The CPS controls operations used by GRC's wind tunnels, propulsion systems lab, engine components research lab, and compressor, turbine and combustor test cells. Used widely throughout the lab, it operates equipment such as exhausters, chillers, cooling towers, compressors, dehydrators, and other such equipment. Through parameters such as pressure, temperature, speed, flow, etc., it performs its primary operations on the major systems of Electrical Dispatch (ED), Central Air Dispatch (CAD), Central Air Equipment Building (CAEB), and Engine Research Building (ERB). In order for the CPS to continue its operations at Glenn, a new contract must be awarded. Consequently, one of my primary responsibilities was assisting the Source Evaluation Board (SEB) with the process of awarding the recertification contract of the CPS. The job of the SEB was to evaluate the proposals of the contract bidders and then to present their findings to the Source Selecting Official (SSO). Before the evaluations began, the Center Director established the level of the competition. For this contract, the competition was limited to those companies classified as a small, disadvantaged business. After an industry briefing that explained to qualified companies the CPS and type of work required, each of the interested companies then submitted proposals addressing three components: Mission Suitability, Cost, and Past Performance. These proposals were based off the Statement of Work (SOW) written by the SEB. After companies submitted their proposals, the SEB reviewed all three components and then presented their results to the SSO. While the

  14. Circular Orbit Target Capture Using Space Tether-Net System

    Directory of Open Access Journals (Sweden)

    Guang Zhai

    2013-01-01

    Full Text Available The space tether-net system for on-orbit capture is proposed in this paper. In order to research the dynamic behaviors during system deployment, both free and nonfree deployment dynamics in circular orbit are developed; the system motion with respect to Local Vertical and Local Horizontal frame is also researched with analysis and simulation. The results show that in the case of free deployment, the capture net follows curve trajectories due to the relative orbit dynamic perturbation, and the initial deployment velocities are planned by state transformation equations for static and floating target captures; in the case of non-free deployment, the system undergoes an altitude libration along the Local Vertical, and the analytical solutions that describe the attitude libration are obtained by using variable separation and integration. Finally, the dynamics of postdeployment system is also proved marginally stable if the critical initial conditions are satisfied.

  15. DNA repair systems as targets of cadmium toxicity

    International Nuclear Information System (INIS)

    Giaginis, Constantinos; Gatzidou, Elisavet; Theocharis, Stamatios

    2006-01-01

    Cadmium (Cd) is a heavy metal and a potent carcinogen implicated in tumor development through occupational and environmental exposure. Recent evidence suggests that proteins participating in the DNA repair systems, especially in excision and mismatch repair, are sensitive targets of Cd toxicity. Cd by interfering and inhibiting these DNA repair processes might contribute to increased risk for tumor formation in humans. In the present review, the information available on the interference of Cd with DNA repair systems and their inhibition is summarized. These actions could possibly explain the indirect contribution of Cd to mutagenic effects and/or carcinogenicity

  16. Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

    Science.gov (United States)

    Datsenko, Kirill A.; Jackson, Ryan N.; Wiedenheft, Blake; Severinov, Konstantin; Brouns, Stan J. J.

    2013-01-01

    Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts are processed into small RNAs that guide CRISPR-associated (Cas) proteins to invading nucleic acids by complementary base pairing. However, to avoid autoimmunity it is essential that these RNA-guides exclusively target invading DNA and not complementary DNA sequences (i.e., self-sequences) located in the host's own CRISPR locus. Previous work on the Type III-A CRISPR system from Staphylococcus epidermidis has demonstrated that a portion of the CRISPR RNA-guide sequence is involved in self versus non-self discrimination. This self-avoidance mechanism relies on sensing base pairing between the RNA-guide and sequences flanking the target DNA. To determine if the RNA-guide participates in self versus non-self discrimination in the Type I-E system from Escherichia coli we altered base pairing potential between the RNA-guide and the flanks of DNA targets. Here we demonstrate that Type I-E systems discriminate self from non-self through a base pairing-independent mechanism that strictly relies on the recognition of four unchangeable PAM sequences. In addition, this work reveals that the first base pair between the guide RNA and the PAM nucleotide immediately flanking the target sequence can be disrupted without affecting the interference phenotype. Remarkably, this indicates that base pairing at this position is not involved in foreign DNA recognition. Results in this paper reveal that the Type I-E mechanism of avoiding self sequences and preventing autoimmunity is fundamentally different from that employed by Type III-A systems. We propose the exclusive targeting of PAM-flanked sequences to be termed a target versus non-target discrimination mechanism. PMID:24039596

  17. Los Alamos pulsed spallation neutron source target systems - present and future

    International Nuclear Information System (INIS)

    Russell, G.J.; Daemen, L.L.; Pitcher, E.J.; Brun, T.O.; Hjelm, R.P. Jr.

    1993-01-01

    For the past 16 yr, spallation target-system designers have devoted much time and effort to the design and optimization of pulsed spallation neutron sources. Many concepts have been proposed, but, in practice, only one has been implemented horizontal beam insertion with moderators in wing geometry i.e., until we introduced the innovative split-target/flux-trap-moderator design with a composite reflector shield at the Manuel Lujan, Jr., Neutron Scattering Center (LANSCE). The LANSCE target system design is now considered a classic by spallation target system designers worldwide. LANSCE, a state-of-the-art pulsed spallation neutron source for materials science and nuclear physics research, uses 800-MeV protons from the Clinton P. Anderson Meson Physics Facility. These protons are fed into the proton storage ring to be compressed to 250-ns pulses before being delivered to LANSCE at 20 Hz. LANSCE produces the highest peak neutron flux of any pulsed spallation neutron source in the world

  18. Targeted multidrug delivery system to overcome chemoresistance in breast cancer

    Directory of Open Access Journals (Sweden)

    Tang Y

    2017-01-01

    Full Text Available Yuan Tang,1 Fariborz Soroush,1 Zhaohui Tong,2 Mohammad F Kiani,1 Bin Wang1,3 1Department of Mechanical Engineering, Temple University, Philadelphia, PA, 2Department of Agricultural and Biological Engineering, University of Florida, Gainesville, FL, 3Department of Biomedical Engineering, Widener University, Chester, PA, USA Abstract: Chemotherapy has been widely used in breast cancer patients to reduce tumor size. However, most anticancer agents cannot differentiate between cancerous and normal cells, resulting in severe systemic toxicity. In addition, acquired drug resistance during the chemotherapy treatment further decreases treatment efficacy. With the proper treatment strategy, nanodrug carriers, such as liposomes/immunoliposomes, may be able to reduce undesired side effects of chemotherapy, to overcome the acquired multidrug resistance, and to further improve the treatment efficacy. In this study, a novel combinational targeted drug delivery system was developed by encapsulating antiangiogenesis drug bevacizumab into liposomes and encapsulating chemotherapy drug doxorubicin (DOX into immunoliposomes where the human epidermal growth factor receptor 2 (HER2 antibody was used as a targeting ligand. This novel combinational system was tested in vitro using a HER2 positive and multidrug resistant breast cancer cell line (BT-474/MDR, and in vivo using a xenograft mouse tumor model. In vitro cell culture experiments show that immunoliposome delivery led to a high cell nucleus accumulation of DOX, whereas free DOX was observed mostly near the cell membrane and in cytoplasm due to the action of P-gp. Combining liposomal bevacizumab with immunoliposomal DOX achieved the best tumor growth inhibition and the lowest toxicity. Tumor size decreased steadily within a 60-day observation period indicating a potential synergistic effect between DOX and bevacizumab through the targeted delivery. Our findings clearly indicate that tumor growth was significantly

  19. A computational framework for modeling targets as complex adaptive systems

    Science.gov (United States)

    Santos, Eugene; Santos, Eunice E.; Korah, John; Murugappan, Vairavan; Subramanian, Suresh

    2017-05-01

    Modeling large military targets is a challenge as they can be complex systems encompassing myriad combinations of human, technological, and social elements that interact, leading to complex behaviors. Moreover, such targets have multiple components and structures, extending across multiple spatial and temporal scales, and are in a state of change, either in response to events in the environment or changes within the system. Complex adaptive system (CAS) theory can help in capturing the dynamism, interactions, and more importantly various emergent behaviors, displayed by the targets. However, a key stumbling block is incorporating information from various intelligence, surveillance and reconnaissance (ISR) sources, while dealing with the inherent uncertainty, incompleteness and time criticality of real world information. To overcome these challenges, we present a probabilistic reasoning network based framework called complex adaptive Bayesian Knowledge Base (caBKB). caBKB is a rigorous, overarching and axiomatic framework that models two key processes, namely information aggregation and information composition. While information aggregation deals with the union, merger and concatenation of information and takes into account issues such as source reliability and information inconsistencies, information composition focuses on combining information components where such components may have well defined operations. Since caBKBs can explicitly model the relationships between information pieces at various scales, it provides unique capabilities such as the ability to de-aggregate and de-compose information for detailed analysis. Using a scenario from the Network Centric Operations (NCO) domain, we will describe how our framework can be used for modeling targets with a focus on methodologies for quantifying NCO performance metrics.

  20. Setting quality and safety priorities in a target-rich environment: an academic medical center's challenge.

    Science.gov (United States)

    Mort, Elizabeth A; Demehin, Akinluwa A; Marple, Keith B; McCullough, Kathryn Y; Meyer, Gregg S

    2013-08-01

    Hospitals are continually challenged to provide safer and higher-quality patient care despite resource constraints. With an ever-increasing range of quality and safety targets at the national, state, and local levels, prioritization is crucial in effective institutional quality goal setting and resource allocation.Organizational goal-setting theory is a performance improvement methodology with strong results across many industries. The authors describe a structured goal-setting process they have established at Massachusetts General Hospital for setting annual institutional quality and safety goals. Begun in 2008, this process has been conducted on an annual basis. Quality and safety data are gathered from many sources, both internal and external to the hospital. These data are collated and classified, and multiple approaches are used to identify the most pressing quality issues facing the institution. The conclusions are subject to stringent internal review, and then the top quality goals of the institution are chosen. Specific tactical initiatives and executive owners are assigned to each goal, and metrics are selected to track performance. A reporting tool based on these tactics and metrics is used to deliver progress updates to senior hospital leadership.The hospital has experienced excellent results and strong organizational buy-in using this effective, low-cost, and replicable goal-setting process. It has led to improvements in structural, process, and outcomes aspects of quality.

  1. Target diagnostic system for the National Ignition Facility (NIF)

    International Nuclear Information System (INIS)

    Leeper, R.J.; Chandler, G.A.; Cooper, G.W.; Derzon, M.S.

    1996-01-01

    A review of recent progress on the design of a diagnostic system proposed for ignition target experiments on the National Ignition Facility (NIF) will be presented. This diagnostic package contains an extensive suite of optical, x-ray, gamma-ray, and neutron diagnostics that enable measurements of the performance of both direct and indirect driven NIF targets. The philosophy used in designing all of the diagnostics in the set has emphasized redundant and independent measurement of fundamental physical quantities relevant to the operation of the NIF target. A unique feature of these diagnostics is that they are being designed to be capable of operating, in the high radiation, EMP, and debris backgrounds expected on the NIF facility. The diagnostic system proposed can be categorized into three broad areas: laser characterization, hohlraum characterization, and capsule performance diagnostics. The operating principles of a representative instrument from each class of diagnostic employed in this package will be summarized and illustrated with data obtained in recent prototype diagnostic tests

  2. Solute carrier transporters: potential targets for digestive system neoplasms

    OpenAIRE

    Xie, Jing; Zhu, Xiao Yan; Liu, Lu Ming; Meng, Zhi Qiang

    2018-01-01

    Jing Xie,1,2 Xiao Yan Zhu,1,2 Lu Ming Liu,1,2 Zhi Qiang Meng1,2 1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People’s Republic of China Abstract: Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues o...

  3. Pancreatic Cancer Gene Therapy: From Molecular Targets to Delivery Systems

    Energy Technology Data Exchange (ETDEWEB)

    Fillat, Cristina, E-mail: cristina.fillat@crg.es; Jose, Anabel; Ros, Xavier Bofill-De; Mato-Berciano, Ana; Maliandi, Maria Victoria; Sobrevals, Luciano [Programa Gens i Malaltia, Centre de Regulació Genòmica-CRG, UPF, Parc de Recerca Biomedica de Barcelona-PRBB and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona (Spain)

    2011-01-18

    The continuous identification of molecular changes deregulating critical pathways in pancreatic tumor cells provides us with a large number of novel candidates to engineer gene-targeted approaches for pancreatic cancer treatment. Targets—both protein coding and non-coding—are being exploited in gene therapy to influence the deregulated pathways to facilitate cytotoxicity, enhance the immune response or sensitize to current treatments. Delivery vehicles based on viral or non-viral systems as well as cellular vectors with tumor homing characteristics are a critical part of the design of gene therapy strategies. The different behavior of tumoral versus non-tumoral cells inspires vector engineering with the generation of tumor selective products that can prevent potential toxic-associated effects. In the current review, a detailed analysis of the different targets, the delivery vectors, the preclinical approaches and a descriptive update on the conducted clinical trials are presented. Moreover, future possibilities in pancreatic cancer treatment by gene therapy strategies are discussed.

  4. Environmental Management System Objectives & Targets Results Summary - FY 2015.

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, Douglas W

    2016-02-01

    Sandia National Laboratories (SNL) Environmental Management System is the integrated approach for members of the workforce to identify and manage environmental risks. Each Fiscal Year (FY) SNL performs an analysis to identify environmental aspects, and the environmental programs associated with them are charged with the task of routinely monitoring and measuring the objectives and targets that are established to mitigate potential impacts of SNL's operations on the environment. An annual summary of the results achieved towards meeting established Sandia Corporation and SNL Site-specific objectives and targets provides a connection to, and rational for, annually revised environmental aspects. The purpose of this document is to summarize the results achieved and documented in FY 2015.

  5. Why Targeted Therapies are Necessary for Systemic Lupus Erythematosus

    Science.gov (United States)

    Durcan, Laura; Petri, Michelle

    2016-01-01

    Systemic lupus erythematosus (SLE) continues to have important morbidity and accelerated mortality despite therapeutic advances. Targeted therapies offer the possibility of improved efficacy with fewer side-effects. Current management strategies rely heavily on non-specific immunosuppressive agents. Prednisone, in particular, is responsible for a considerable burden of later organ damage. There are a multitude of diverse mechanisms of disease activity, immunogenic abnormalities and clinical manifestations to take into consideration in SLE. Many targeted agents with robust mechanistic pre-clinical data and promising early phase studies have ultimately been disappointing in phase III randomized controlled studies. Recent efforts have focused on B cell therapies, in particular given the success of belimumab in clinical trials, with limited success. We remain optimistic regarding other specific therapies being evaluated including interferon alpha blockade. It is likely that in SLE, given the heterogeneity of the population involved, precision medicine is needed, rather than expecting that any single biologic will be universally effective. PMID:27497251

  6. Targeted electrohydrodynamic printing for micro-reservoir drug delivery systems

    International Nuclear Information System (INIS)

    Hwang, Tae Heon; Kim, Jin Bum; Yang, Da Som; Ryu, WonHyoung; Park, Yong-il

    2013-01-01

    Microfluidic drug delivery systems consisting of a drug reservoir and microfluidic channels have shown the possibility of simple and robust modulation of drug release rate. However, the difficulty of loading a small quantity of drug into drug reservoirs at a micro-scale limited further development of such systems. Electrohydrodynamic (EHD) printing was employed to fill micro-reservoirs with controlled amount of drugs in the range of a few hundreds of picograms to tens of micrograms with spatial resolution of as small as 20 µm. Unlike most EHD systems, this system was configured in combination with an inverted microscope that allows in situ targeting of drug loading at micrometer scale accuracy. Methylene blue and rhodamine B were used as model drugs in distilled water, isopropanol and a polymer solution of a biodegradable polymer and dimethyl sulfoxide (DMSO). Also tetracycline-HCl/DI water was used as actual drug ink. The optimal parameters of EHD printing to load an extremely small quantity of drug into microscale drug reservoirs were investigated by changing pumping rates, the strength of an electric field and drug concentration. This targeted EHD technique was used to load drugs into the microreservoirs of PDMS microfluidic drug delivery devices and their drug release performance was demonstrated in vitro. (paper)

  7. Pathogenic inflammation and its therapeutic targeting in systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Timothy Andrew Gottschalk

    2015-10-01

    Full Text Available Systemic Lupus Erythematosus (SLE, lupus is a highly complex and heterogeneous autoimmune disease that most often afflicts women in their child-bearing years. It is characterized by circulating self-reactive antibodies that deposit in tissues including skin, kidneys and brain, and the ensuing inflammatory response can lead to irreparable tissue damage. Over many years, clinical trials in SLE have focused on agents that control B and T lymphocyte activation, and, with the single exception of an agent known as Belimumab which targets the B cell survival factor BAFF, they have been disappointing. At present, standard therapy for SLE with mild disease is the agent hydroxychloroquine. During disease flares, steroids are often used, while the more severe manifestations with major organ involvement warrant potent, broad-spectrum immuno-suppression with cyclophosphamide or mycophenolate. Current treatments have severe and dose-limiting toxicities and thus a more specific therapy targeting a causative factor or signaling pathway would be greatly beneficial in SLE treatment. Moreover, the ability to control inflammation alongside B cell activation may be a superior approach for disease control. There has been a recent focus on the innate immune system and associated inflammation, which has uncovered key players in driving the pathogenesis of SLE. Delineating some of these intricate inflammatory mechanisms has been possible with studies using spontaneous mouse mutants and genetically engineered mice. These strains, to varying degrees, exhibit hallmarks of the human disease and therefore have been utilized to model human SLE and to test new drugs. Developing a better understanding of the initiation and perpetuation of disease in SLE may uncover suitable novel targets for therapeutic intervention. Here we discuss the involvement of inflammation in SLE disease pathogenesis, with a focus on several key proinflammatory cytokines and myeloid growth factors, and

  8. Pathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus Erythematosus

    Science.gov (United States)

    Gottschalk, Timothy A.; Tsantikos, Evelyn; Hibbs, Margaret L.

    2015-01-01

    Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous autoimmune disease that most often afflicts women in their child-bearing years. It is characterized by circulating self-reactive antibodies that deposit in tissues, including skin, kidneys, and brain, and the ensuing inflammatory response can lead to irreparable tissue damage. Over many years, clinical trials in SLE have focused on agents that control B- and T-lymphocyte activation, and, with the single exception of an agent known as belimumab which targets the B-cell survival factor BAFF, they have been disappointing. At present, standard therapy for SLE with mild disease is the agent hydroxychloroquine. During disease flares, steroids are often used, while the more severe manifestations with major organ involvement warrant potent, broad-spectrum immunosuppression with cyclophosphamide or mycophenolate. Current treatments have severe and dose-limiting toxicities and thus a more specific therapy targeting a causative factor or signaling pathway would be greatly beneficial in SLE treatment. Moreover, the ability to control inflammation alongside B-cell activation may be a superior approach for disease control. There has been a recent focus on the innate immune system and associated inflammation, which has uncovered key players in driving the pathogenesis of SLE. Delineating some of these intricate inflammatory mechanisms has been possible with studies using spontaneous mouse mutants and genetically engineered mice. These strains, to varying degrees, exhibit hallmarks of the human disease and therefore have been utilized to model human SLE and to test new drugs. Developing a better understanding of the initiation and perpetuation of disease in SLE may uncover suitable novel targets for therapeutic intervention. Here, we discuss the involvement of inflammation in SLE disease pathogenesis, with a focus on several key proinflammatory cytokines and myeloid growth factors, and review the known

  9. Accuracy of position measurement method using Arago spot for inertial fusion energy target tracking system

    International Nuclear Information System (INIS)

    Saruta, Koichi; Tsuji, Ryusuke

    2007-01-01

    The accuracy of a position measurement method using the Arago spot is reported for an inertial fusion energy (IFE) target tracking system, where the position of the target is determined by the position of the Arago spot, which is a bright spot appearing in the central portion of the diffraction pattern of a spherical obstacle. We use a He-Ne laser as the light source and a charge-coupled device (CCD) camera with a microscope objective lens to magnify and record the diffraction pattern of a spherical target. We examine two different algorithms to determine the center of the Arago spot in order to compare the measurement performances. The experimental results show that the position of a 5-mm-diameter target can be obtained with a measurement resolution of 1 μm and an rms measurement error of less than 0.2μm for both algorithms when the distance between the target and the microscope objective lens is 5 cm. (author)

  10. Small Radioisotope Power System Testing at NASA Glenn Research Center

    Science.gov (United States)

    Dugala, Gina; Bell, Mark; Oriti, Salvatore; Fraeman, Martin; Frankford, David; Duven, Dennis

    2013-01-01

    In April 2009, NASA Glenn Research Center (GRC) formed an integrated product team (IPT) to develop a Small Radioisotope Power System (SRPS) utilizing a single Advanced Stirling Convertor (ASC) with passive balancer. A single ASC produces approximately 80 We making this system advantageous for small distributed lunar science stations. The IPT consists of Sunpower, Inc., to provide the single ASC with a passive balancer, The Johns Hopkins University Applied Physics Laboratory (JHUAPL) to design an engineering model Single Convertor Controller (SCC) for an ASC with a passive balancer, and NASA GRC to provide technical support to these tasks and to develop a simulated lunar lander test stand. The single ASC with a passive balancer, simulated lunar lander test stand, and SCC were delivered to GRC and were tested as a system. The testing sequence at GRC included SCC fault tolerance, integration, electromagnetic interference (EMI), vibration, and extended operation testing. The SCC fault tolerance test characterized the SCCs ability to handle various fault conditions, including high or low bus power consumption, total open load or short circuit, and replacing a failed SCC card while the backup maintains control of the ASC. The integrated test characterized the behavior of the system across a range of operating conditions, including variations in cold-end temperature and piston amplitude, including the emitted vibration to both the sensors on the lunar lander and the lunar surface. The EMI test characterized the AC and DC magnetic and electric fields emitted by the SCC and single ASC. The vibration test confirms the SCCs ability to control the single ASC during launch. The extended operation test allows data to be collected over a period of thousands of hours to obtain long term performance data of the ASC with a passive balancer and the SCC. This paper will discuss the results of each of these tests.

  11. Joint Space Operations Center (JSpOC) Mission System (JMS)

    Science.gov (United States)

    Morton, M.; Roberts, T.

    2011-09-01

    US space capabilities benefit the economy, national security, international relationships, scientific discovery, and our quality of life. Realizing these space responsibilities is challenging not only because the space domain is increasingly congested, contested, and competitive but is further complicated by the legacy space situational awareness (SSA) systems approaching end of life and inability to provide the breadth of SSA and command and control (C2) of space forces in this challenging domain. JMS will provide the capabilities to effectively employ space forces in this challenging domain. Requirements for JMS were developed based on regular, on-going engagement with the warfighter. The use of DoD Architecture Framework (DoDAF) products facilitated requirements scoping and understanding and transferred directly to defining and documenting the requirements in the approved Capability Development Document (CDD). As part of the risk reduction efforts, the Electronic System Center (ESC) JMS System Program Office (SPO) fielded JMS Capability Package (CP) 0 which includes an initial service oriented architecture (SOA) and user defined operational picture (UDOP) along with force status, sensor management, and analysis tools. Development efforts are planned to leverage and integrate prototypes and other research projects from Defense Advanced Research Projects Agency, Air Force Research Laboratories, Space Innovation and Development Center, and Massachusetts Institute of Technology/Lincoln Laboratories. JMS provides a number of benefits to the space community: a reduction in operational “transaction time” to accomplish key activities and processes; ability to process the increased volume of metric observations from new sensors (e.g., SBSS, SST, Space Fence), as well as owner/operator ephemerides thus enhancing the high accuracy near-real-time catalog, and greater automation of SSA data sharing supporting collaboration with government, civil, commercial, and foreign

  12. Scalable DDoS Mitigation System for Data Centers

    Directory of Open Access Journals (Sweden)

    Zdenek Martinasek

    2015-01-01

    Full Text Available Distributed Denial of Service attacks (DDoS have been used by attackers for over two decades because of their effectiveness. This type of the cyber-attack is one of the most destructive attacks in the Internet. In recent years, the intensity of DDoS attacks has been rapidly increasing and the attackers combine more often different techniques of DDoS to bypass the protection. Therefore, the main goal of our research is to propose a DDoS solution that allows to increase the filtering capacity linearly and allows to protect against the combination of attacks. The main idea is to develop the DDoS defense system in the form of a portable software image that can be installed on the reserve hardware capacities. During a DDoS attack, these servers will be used as filters of this DDoS attack. Our solution is suitable for data centers and eliminates some lacks of commercial solutions. The system employs modular DDoS filters in the form of special grids containing specific protocol parameters and conditions.

  13. Centering Pregnancy in Missouri: A System Level Analysis

    Directory of Open Access Journals (Sweden)

    Pamela K. Xaverius

    2014-01-01

    Full Text Available Background. Centering Pregnancy (CP is an effective method of delivering prenatal care, yet providers have been slow to adopt the CP model. Our main hypothesis is that a site’s adoption of CP is contingent upon knowledge of the CP, characteristics health care personnel, anticipated patient impact, and system readiness. Methods. Using a matched, pretest-posttest, observational design, 223 people completed pretest and posttest surveys. Our analysis included the effect of the seminar on the groups’ knowledge of CP essential elements, barriers to prenatal care, and perceived value of CP to the patients and to the system of care. Results. Before the CP Seminar only 34% of respondents were aware of the model, while knowledge significantly after the Seminar. The three greatest improvements were in understanding that the group is conducted in a circle, the health assessment occurs in the group space, and a facilitative leadership style is used. Child care, transportation, and language issues were the top three barriers. The greatest improvements reported for patients included improvements in timeliness, patient-centeredness and efficiency, although readiness for adoption was influenced by costs, resources, and expertise. Discussion. Readiness to adopt CP will require support for the start-up and sustainability of this model.

  14. Targeting Parents for Childhood Weight Management: Development of a Theory-Driven and User-Centered Healthy Eating App

    Science.gov (United States)

    Lahiri, Sudakshina; Brown, Katherine Elizabeth

    2015-01-01

    Background The proliferation of health promotion apps along with mobile phones' array of features supporting health behavior change offers a new and innovative approach to childhood weight management. However, despite the critical role parents play in children’s weight related behaviors, few industry-led apps aimed at childhood weight management target parents. Furthermore, industry-led apps have been shown to lack a basis in behavior change theory and evidence. Equally important remains the issue of how to maximize users’ engagement with mobile health (mHealth) interventions where there is growing consensus that inputs from the commercial app industry and the target population should be an integral part of the development process. Objective The aim of this study is to systematically design and develop a theory and evidence-driven, user-centered healthy eating app targeting parents for childhood weight management, and clearly document this for the research and app development community. Methods The Behavior Change Wheel (BCW) framework, a theoretically-based approach for intervention development, along with a user-centered design (UCD) philosophy and collaboration with the commercial app industry, guided the development process. Current evidence, along with a series of 9 focus groups (total of 46 participants) comprised of family weight management case workers, parents with overweight and healthy weight children aged 5-11 years, and consultation with experts, provided data to inform the app development. Thematic analysis of focus groups helped to extract information related to relevant theoretical, user-centered, and technological components to underpin the design and development of the app. Results Inputs from parents and experts working in the area of childhood weight management helped to identify the main target behavior: to help parents provide appropriate food portion sizes for their children. To achieve this target behavior, the behavioral diagnosis

  15. Targeting Parents for Childhood Weight Management: Development of a Theory-Driven and User-Centered Healthy Eating App.

    Science.gov (United States)

    Curtis, Kristina Elizabeth; Lahiri, Sudakshina; Brown, Katherine Elizabeth

    2015-06-18

    The proliferation of health promotion apps along with mobile phones' array of features supporting health behavior change offers a new and innovative approach to childhood weight management. However, despite the critical role parents play in children's weight related behaviors, few industry-led apps aimed at childhood weight management target parents. Furthermore, industry-led apps have been shown to lack a basis in behavior change theory and evidence. Equally important remains the issue of how to maximize users' engagement with mobile health (mHealth) interventions where there is growing consensus that inputs from the commercial app industry and the target population should be an integral part of the development process. The aim of this study is to systematically design and develop a theory and evidence-driven, user-centered healthy eating app targeting parents for childhood weight management, and clearly document this for the research and app development community. The Behavior Change Wheel (BCW) framework, a theoretically-based approach for intervention development, along with a user-centered design (UCD) philosophy and collaboration with the commercial app industry, guided the development process. Current evidence, along with a series of 9 focus groups (total of 46 participants) comprised of family weight management case workers, parents with overweight and healthy weight children aged 5-11 years, and consultation with experts, provided data to inform the app development. Thematic analysis of focus groups helped to extract information related to relevant theoretical, user-centered, and technological components to underpin the design and development of the app. Inputs from parents and experts working in the area of childhood weight management helped to identify the main target behavior: to help parents provide appropriate food portion sizes for their children. To achieve this target behavior, the behavioral diagnosis revealed the need for eliciting change in

  16. The new control system of the SPS target sector

    CERN Document Server

    Carlier, E; Mecredy, N; O'Leary, J

    1999-01-01

    The SPS, the Super Proton Synchrotron at CERN, is an accelerator originally designed and commissioned in 1976 for protons. The control system of the SPS target stations, beam absorbers and other aperture limiting devices was developed in the seventies. It was mainly based on home made electronics and equipment dependent software. With time, this electronics has become obsolete, difficult to maintain in operation and not suitable for integration into a modern control system. In 1997, a project was set up to modernise the electronics and the related software. The new control system is largely based on standard industrial hardware and software components. SIEMENS Simatic S7-300 programmable logic controllers have been used as equipment controllers and connected through PROFIBUS to a Windows-NT front-end PC running the SIEMENS WinCC SCADA package which acts as local controller and remote access gateway. This fully industrial solution has been successfully integrated into the actual SPS accelerator control infrast...

  17. Target-Tracking Camera for a Metrology System

    Science.gov (United States)

    Liebe, Carl; Bartman, Randall; Chapsky, Jacob; Abramovici, Alexander; Brown, David

    2009-01-01

    An analog electronic camera that is part of a metrology system measures the varying direction to a light-emitting diode that serves as a bright point target. In the original application for which the camera was developed, the metrological system is used to determine the varying relative positions of radiating elements of an airborne synthetic aperture-radar (SAR) antenna as the airplane flexes during flight; precise knowledge of the relative positions as a function of time is needed for processing SAR readings. It has been common metrology system practice to measure the varying direction to a bright target by use of an electronic camera of the charge-coupled-device or active-pixel-sensor type. A major disadvantage of this practice arises from the necessity of reading out and digitizing the outputs from a large number of pixels and processing the resulting digital values in a computer to determine the centroid of a target: Because of the time taken by the readout, digitization, and computation, the update rate is limited to tens of hertz. In contrast, the analog nature of the present camera makes it possible to achieve an update rate of hundreds of hertz, and no computer is needed to determine the centroid. The camera is based on a position-sensitive detector (PSD), which is a rectangular photodiode with output contacts at opposite ends. PSDs are usually used in triangulation for measuring small distances. PSDs are manufactured in both one- and two-dimensional versions. Because it is very difficult to calibrate two-dimensional PSDs accurately, the focal-plane sensors used in this camera are two orthogonally mounted one-dimensional PSDs.

  18. 23 CFR 752.8 - Privately operated information centers and systems.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Privately operated information centers and systems. 752... may permit privately operated information centers and systems which conform with the standards of this... AND ENVIRONMENT LANDSCAPE AND ROADSIDE DEVELOPMENT § 752.8 Privately operated information centers and...

  19. Solute carrier transporters: potential targets for digestive system neoplasms.

    Science.gov (United States)

    Xie, Jing; Zhu, Xiao Yan; Liu, Lu Ming; Meng, Zhi Qiang

    2018-01-01

    Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues of digestive systems and mediate specific uptake of small molecule substrates in facilitative manner. Given the important role of SLC proteins in maintaining normal functions of digestive system, dysregulation of these protein in digestive system neoplasms may deliver biological and clinical significance that deserves systemic studies. In this review, we critically summarized the recent advances in understanding the role of SLC proteins in digestive system neoplasms. We highlighted that several SLC subfamilies, including metal ion transporters, transporters of glucose and other sugars, transporters of urea, neurotransmitters and biogenic amines, ammonium and choline, inorganic cation/anion transporters, transporters of nucleotide, amino acid and oligopeptide organic anion transporters, transporters of vitamins and cofactors and mitochondrial carrier, may play important roles in mediating the initiation, progression, metastasis, and chemoresistance of digestive system neoplasms. Proteins in these SLC subfamilies may also have diagnostic and prognostic values to particular cancer types. Differential expression of SLC proteins in tumors of digestive system was analyzed by extracting data from human cancer database, which revealed that the roles of SLC proteins may either be dependent on the substrates they transport or be tissue specific. In addition, small molecule modulators that pharmacologically regulate the functions of SLC proteins were discussed for their possible application in the treatment of digestive system neoplasms. This review highlighted the potential of SLC family proteins as drug target for the treatment of digestive system neoplasms.

  20. Space and Missile Systems Center Standard: Systems Engineering Requirements and Products

    Science.gov (United States)

    2013-07-01

    MISSILE SYSTEMS CENTER Air Force Space Command 483 N. Aviation Blvd. El Segundo, CA 90245 4. This standard has been approved for use on all Space...Any RF receiver with a burnout level of less than 30 dBm (1 mW). b. A summary of all significant areas are addressed in the EMC Control Plan...address 7. Date Submitted 8. Preparing Activity Space and Missile Systems Center AIR FORCE SPACE COMMAND 483 N. Aviation Blvd. El Segundo, CA 91245 Attention: SMC/EN February 2013

  1. False targets vs. redundancy in homogeneous parallel systems

    International Nuclear Information System (INIS)

    Levitin, Gregory; Hausken, Kjell

    2009-01-01

    System defense against natural threats and disasters that have a stochastic nature includes providing redundancy and protecting system elements. The defense against strategic intentional attacks can also include deploying false targets aimed at misleading the attacker. Distribution of the available resources among different defensive means is an important problem that arises in organizing the defense of complex civil infrastructures, industrial systems or military objects. The article considers defense resource allocation in a system exposed to external intentional attack. The expected damage caused by the attack is evaluated as system unsupplied demand. The defender distributes its limited resource between deploying redundant genuine elements and false elements, both of which are targets of attack. The attacker attacks a subset of the elements and distributes its limited resource evenly among the attacked elements. Two cases are considered: in the first one the number of attacked elements and the vulnerability of each genuine element are fixed and the defense resource distribution is determined as a solution of an optimization problem; in the second one the number of attacked elements is the attacker's free choice variable and the element's vulnerability depends on a contest determined by the defender's and attacker's resources allocated to each element. The defender's optimal resource distribution strategy is determined as a solution of a two-period minmax game. It is shown that the optimal number of genuine elements decreases monotonically with the growth of the element cost and vulnerability, whereas the optimal number of false elements demonstrates non-monotonic behavior. The contest intensity is an important factor influencing the optimal defense resource distribution. It cannot be ignored when the defense strategy is determined, and it thus also impacts the attack strategy

  2. Do We Need a Patient-Centered Target for Systolic Blood Pressure in Hypertensive Patients With Type 2 Diabetes Mellitus?

    Science.gov (United States)

    Wan, Eric Yuk Fai; Yu, Esther Yee Tak; Fung, Colman Siu Cheung; Chin, Weng Yee; Fong, Daniel Yee Tak; Chan, Anca Ka Chun; Lam, Cindy Lo Kuen

    2017-12-01

    The current trend on diabetes mellitus management advocates replacing the paradigm from a uniform to an individualized patient-centered systolic blood pressure (SBP), but there is no consensus on the achieved treatment goals of SBP level. The study aimed at evaluating the association between SBP and the risk of cardiovascular diseases (CVD) and all-cause mortality for diabetic patients to identify patient-centered treatment targets. A retrospective study was conducted on 95 086 Chinese adult primary care patients with type 2 diabetes mellitus and hypertension. Using the average of the annual SBP records (updated SBP) over a median follow-up of 5.9 years, the risks of overall CVD, all-cause mortality, and their composite associated with SBP were evaluated using Cox proportional hazards regression. Subgroup analysis was performed on the incidence of CVD by stratifying patient's baseline characteristics. The SBP range for the lowest risk of CVD and all-cause mortality was 130 to 134 mm Hg among type 2 diabetes mellitus population. A J-shaped curvilinear relationship was identified between SBP and risk of CVD and all-cause mortality, irrespective of patients' characteristics. The findings showed that all patients with SBP diabetic management. © 2017 American Heart Association, Inc.

  3. Endocannabinoid System: A Multi-Facet Therapeutic Target.

    Science.gov (United States)

    Kaur, Rimplejeet; Ambwani, Sneha R; Singh, Surjit

    2016-01-01

    the therapeutic targets for both cannabinoid receptor agonists and antagonists. One challenge is to develop drugs that target only cannabinoid receptors in a particular tissue and another is to invent drugs that act selectively on cannabinoid receptors located outside the blood brain barrier. Besides this, development of the suitable dosage forms with maximum efficacy and minimum adverse effects is also warranted. Another angle to be introspected for therapeutic abilities of this group of drugs is non-CB1 and non-CB2 receptor targets for cannabinoids. In order to successfully exploit the therapeutic potential of endocannabinoid system, it is imperative to further characterize the endocannabinoid system in terms of identification of the exact cellular location of cannabinoid receptors and their role as "protective" and "disease inducing substance", time-dependent changes in the expression of cannabinoid receptors.

  4. Challenges in thermal and hydraulic analysis of ADS target systems

    International Nuclear Information System (INIS)

    Groetzbach, G.; Batta, A.; Lefhalm, C.-H.; Otic, I.

    2004-01-01

    The liquid metal cooled spallation targets of Accelerator Driven nuclear reactor Systems obey high thermal loads; in addition some flow and cooling conditions are of a prototypical character; in contrast the operating conditions for the engaged materials are narrow; thus, the target development requires a very careful analysis by experimental and numerical means. Especially the cooling of the steel window, which is heated by the proton beam, needs special care. Some of the main goals of the experimental and numerical analyses of the thermal dynamics of those systems are discusses. The prediction of locally detached flows and of flows with larger recirculation areas suffers from insufficient turbulence modeling; this has to be compensated by using prototypical model experiments, e.g. with water, to select the adequate models and numerical schemes. The well known problems with the Reynolds analogy in predicting the heat transfer in liquid metals requires always prototypic liquid metal experiments to select and adapt the turbulent heat flux models. The uncertainties in liquid metal experiments cannot be neglected; so it is necessary to perform CFD calculations and experiments always hand in hand and to develop improve turbulent heat flux models. One contribution to an improved 3 or 4-equation model is deduced from recent Direct Numerical Simulation (DNS) data. (author)

  5. Target Diagnostic Control System Implementation for the National Ignition Facility

    International Nuclear Information System (INIS)

    Shelton, R.T.; Kamperschroer, J.H.; Lagin, L.J.; Nelson, J.R.; O'Brien, D.W.

    2010-01-01

    The extreme physics of targets shocked by NIF's 192-beam laser are observed by a diverse suite of diagnostics. Many diagnostics are being developed by collaborators at other sites, but ad hoc controls could lead to unreliable and costly operations. A Diagnostic Control System (DCS) framework for both hardware and software facilitates development and eases integration. Each complex diagnostic typically uses an ensemble of electronic instruments attached to sensors, digitizers, cameras, and other devices. In the DCS architecture each instrument is interfaced to a low-cost Windows XP processor and Java application. Each instrument is aggregated with others as needed in the supervisory system to form an integrated diagnostic. The Java framework provides data management, control services and operator GUI generation. DCS instruments are reusable by replication with reconfiguration for specific diagnostics in XML. Advantages include minimal application code, easy testing, and high reliability. Collaborators save costs by assembling diagnostics with existing DCS instruments. This talk discusses target diagnostic instrumentation used on NIF and presents the DCS architecture and framework.

  6. CHAOS: An SDN-Based Moving Target Defense System

    Directory of Open Access Journals (Sweden)

    Yuan Shi

    2017-01-01

    Full Text Available Moving target defense (MTD has provided a dynamic and proactive network defense to reduce or move the attack surface that is available for exploitation. However, traditional network is difficult to realize dynamic and active security defense effectively and comprehensively. Software-defined networking (SDN points out a brand-new path for building dynamic and proactive defense system. In this paper, we propose CHAOS, an SDN-based MTD system. Utilizing the programmability and flexibility of SDN, CHAOS obfuscates the attack surface including host mutation obfuscation, ports obfuscation, and obfuscation based on decoy servers, thereby enhancing the unpredictability of the networking environment. We propose the Chaos Tower Obfuscation (CTO method, which uses the Chaos Tower Structure (CTS to depict the hierarchy of all the hosts in an intranet and define expected connection and unexpected connection. Moreover, we develop fast CTO algorithms to achieve a different degree of obfuscation for the hosts in each layer. We design and implement CHAOS as an application of SDN controller. Our approach makes it very easy to realize moving target defense in networks. Our experimental results show that a network protected by CHAOS is capable of decreasing the percentage of information disclosure effectively to guarantee the normal flow of traffic.

  7. Automated Navigation System based on Weapon-Target Assignment

    Directory of Open Access Journals (Sweden)

    Mohammad Khairudin

    2011-12-01

    Full Text Available Operating of weapon on the tank is mostly by manually. It is not desired performance for a critical operation. An automatic control system is required to operate the weapon with the target while maintaining the accuracy. In this paper has designed an automatic weapon control system using object image proccessing. Various an image processing methods used to improve the weapon accuracy to obtain the intended target. The method used in digital image processing is the Camshift motion tracking method. This method is compared with the Lucas Canade motion tracking method. This comparison is conducted to found more precise results between the two methods. Results of object image processing are used to control the direction of the weapon that towards the desired goal. The results show that the implementation of the Lucas Canade motion tracking method using fire simulation tools have been successful. The performance of the Lucas Canade motion tracking methods is better than the CamShift method. Using Lucas Canade method for weapon controller is accordance with the purposes.

  8. Cooling System for the Merit High-Power Target Experiment

    CERN Document Server

    Haug, F; Silva, P; Pezzeti, M; Pavlov, O; Pirotte, O; Metselaar, J; Efthymiopoulos, I; Fabich, A; Lettry, J; Kirk, H G; McDonald, K T; Titus, P; Bennett, J R J

    2010-01-01

    MERIT is a proof-of-principle experiment of a target station suitable as source for future muon colliders or neutrino factories. When installed at the CERN (European Organization for Nuclear Research) PS (Proton Synchrotron)complex fast-extracted high-intensity proton beams intercepted a free mercury jet inside a normal-conducting, pulsed 15-T capture solenoid magnet cooled with liquid nitrogen. Up to 25 MJ of Joule heat was dissipated in the magnet during a pulse. The fully automated, remotely controlled cryogenic system of novel design permitted the transfer of nitrogen by the sole means of differential pressures inside the vessels. This fast cycling system permitted several hundred tests in less than three weeks during the 2007 data taking campaign.

  9. Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets.

    Science.gov (United States)

    Rico, E P; Rosemberg, D B; Seibt, K J; Capiotti, K M; Da Silva, R S; Bonan, C D

    2011-01-01

    Recent advances in neurobiology have emphasized the study of brain structure and function and its association with numerous pathological and toxicological events. Neurotransmitters are substances that relay, amplify, and modulate electrical signals between neurons and other cells. Neurotransmitter signaling mediates rapid intercellular communication by interacting with cell surface receptors, activating second messenger systems and regulating the activity of ion channels. Changes in the functional balance of neurotransmitters have been implicated in the failure of central nervous system function. In addition, abnormalities in neurotransmitter production or functioning can be induced by several toxicological compounds, many of which are found in the environment. The zebrafish has been increasingly used as an animal model for biomedical research, primarily due to its genetic tractability and ease of maintenance. These features make this species a versatile tool for pre-clinical drug discovery and toxicological investigations. Here, we present a review regarding the role of different excitatory and inhibitory neurotransmitter systems in zebrafish, such as dopaminergic, serotoninergic, cholinergic, purinergic, histaminergic, nitrergic, glutamatergic, glycinergic, and GABAergic systems, and emphasizing their features as pharmacological and toxicological targets. The increase in the global knowledge of neurotransmitter systems in zebrafish and the elucidation of their pharmacological and toxicological aspects may lead to new strategies and appropriate research priorities to offer insights for biomedical and environmental research. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Very high stability systems: LMJ target alignment system and MTG imager test setup

    Science.gov (United States)

    Compain, Eric; Maquet, Philippe; Kunc, Thierry; Marque, Julien; Lauer-Solelhac, Maxime; Delage, Laurent; Lanternier, Catherine

    2015-09-01

    Most of space instruments and research facilities require test equipment with demanding opto-mechanical stability. In some specific cases, when the stability performance directly drives the final performance of the scientific mission and when feasibility is questionable, specific methods must be implemented for the associated technical risk management. In present paper, we will present our heritage in terms of methodology, design, test and the associated results for two specific systems : the SOPAC-POS and the MOTA, generating new references for future developments. From a performance point of view, we will emphasis on following key parameters : design symmetry, thermal load management, and material and structural choices. From a method point of view the difficulties arise first during design, from the strong coupling between the thermal, mechanical and optical performance models, and then during testing, from the difficulty of conceiving test setup having appropriate performance level. We will present how these limitations have been overcome. SOPAC-POS is the target alignment system of the LMJ, Laser Mega Joule, the French inertial confinement fusion research center. Its stability has been demonstrated by tests in 2014 after 10 years of research and development activities, achieving 1μm stability @ 6m during one hour periods. MOTA is an Optical Ground Support Equipment aiming at qualifying by tests the Flexible Combined Imager (FCI). FCI is an instrument for the meteorological satellite MTG-I, a program of and funded by the European Space Agency and under prime contractorship of Thales Alenia Space. Optimized design will allow to get better than 0.2 μrad stability for one hour periods, as required for MTF measurement.

  11. System Studies for the ADTF: Target and Materials Test Station

    International Nuclear Information System (INIS)

    Cappiello, M.; Pitcher, E.; Pasamehmetoglu, K.

    2002-01-01

    To meet the objectives of the Advanced Accelerator Applications (AAA) program, the Accelerator-Driven Test Facility (ADTF) provides a world-class accelerator-driven test facility to: - Provide the capability to assess technology options for the transmutation of spent nuclear fuel and waste through a proof-of-performance. - Provide a user facility that allows testing of advanced nuclear technologies and applications, material science and research, experimental physics, and conventional nuclear engineering science applications. - Provide the capability, through upgrades or additions to the ADTF accelerator, to produce tritium for defense purposes, if required. - Provide the capability, through upgrades or additions, to produce radioisotopes for medical and commercial purposes. These missions are diverse and demand a facility with significant flexibility. In order to meet them, it is envisioned that we construct two target stations: the Target and Materials Test (TMT) station and the Subcritical Multiplier (SCM) test station. The two test stations share common hot-cell facilities for post-irradiation examination. It is expected the TMT will come online first, closely followed by the SCM. The TMT will provide the capability to: - Irradiate small samples of proposed ATW (accelerator-driven transmutation of waste) fuels and materials at prototypic flux, temperature, and coolant conditions (requires intense source of neutrons). - Perform transient testing. - Test liquid (lead-bismuth) and solid spallation targets with water, sodium, or helium coolant. - Test generation-IV fuels for advance nuclear systems (requires high-intensity thermal flux). - Irradiate fission product transmutation targets. - Test advanced fuel and coolant combinations, including helium, water, sodium, and lead-bismuth. - Produce isotopes for commercial and medical applications. - Perform neutron physics experiments. The SCM will provide the capability to: - Irradiate large samples of proposed ATW

  12. 20 CFR 670.530 - Are Job Corps centers required to maintain a student accountability system?

    Science.gov (United States)

    2010-04-01

    ... student accountability system? 670.530 Section 670.530 Employees' Benefits EMPLOYMENT AND TRAINING... accountability system? Yes, each Job Corps center must establish and operate an effective system to account for... student absence. Each center must operate its student accountability system according to requirements and...

  13. Evaluating system reliability and targeted hardening strategies of power distribution systems subjected to hurricanes

    International Nuclear Information System (INIS)

    Salman, Abdullahi M.; Li, Yue; Stewart, Mark G.

    2015-01-01

    Over the years, power distribution systems have been vulnerable to extensive damage from hurricanes which can cause power outage resulting in millions of dollars of economic losses and restoration costs. Most of the outage is as a result of failure of distribution support structures. Over the years, various methods of strengthening distribution systems have been proposed and studied. Some of these methods, such as undergrounding of the system, have been shown to be unjustified from an economic point of view. A potential cost-effective strategy is targeted hardening of the system. This, however, requires a method of determining critical parts of a system that when strengthened, will have greater impact on reliability. This paper presents a framework for studying the effectiveness of targeted hardening strategies on power distribution systems subjected to hurricanes. The framework includes a methodology for evaluating system reliability that relates failure of poles and power delivery, determination of critical parts of a system, hurricane hazard analysis, and consideration of decay of distribution poles. The framework also incorporates cost analysis that considers economic losses due to power outage. A notional power distribution system is used to demonstrate the framework by evaluating and comparing the effectiveness of three hardening measures. - Highlight: • Risk assessment of power distribution systems subjected to hurricanes is carried out. • Framework for studying effectiveness of targeted hardening strategies is presented. • A system reliability method is proposed. • Targeted hardening is cost effective for existing systems. • Economic losses due to power outage should be considered for cost analysis.

  14. Virtual Targets Center (VTC)

    Data.gov (United States)

    Federal Laboratory Consortium — The VTC is a joint effort with PEO STRI, PM ITTS TMO to provide signature management and predictive signature design services. It is organized into three areas: 1)...

  15. Large space antenna communications systems: Integrated Langley Research Center/Jet Propulsion Laboratory development activities. 2: Langley Research Center activities

    Science.gov (United States)

    Cambell, T. G.; Bailey, M. C.; Cockrell, C. R.; Beck, F. B.

    1983-01-01

    The electromagnetic analysis activities at the Langley Research Center are resulting in efficient and accurate analytical methods for predicting both far- and near-field radiation characteristics of large offset multiple-beam multiple-aperture mesh reflector antennas. The utilization of aperture integration augmented with Geometrical Theory of Diffraction in analyzing the large reflector antenna system is emphasized.

  16. Specification for Visual Requirements of Work-Centered Software Systems

    National Research Council Canada - National Science Library

    Knapp, James R; Chung, Soon M; Schmidt, Vincent A

    2006-01-01

    .... In order to ensure the coherent development and delivery of work-centered software products, WCSS visual requirements must be specified to capture the cognitive aspects of the user interface design...

  17. Alkylation damage by lipid electrophiles targets functional protein systems.

    Science.gov (United States)

    Codreanu, Simona G; Ullery, Jody C; Zhu, Jing; Tallman, Keri A; Beavers, William N; Porter, Ned A; Marnett, Lawrence J; Zhang, Bing; Liebler, Daniel C

    2014-03-01

    Protein alkylation by reactive electrophiles contributes to chemical toxicities and oxidative stress, but the functional impact of alkylation damage across proteomes is poorly understood. We used Click chemistry and shotgun proteomics to profile the accumulation of proteome damage in human cells treated with lipid electrophile probes. Protein target profiles revealed three damage susceptibility classes, as well as proteins that were highly resistant to alkylation. Damage occurred selectively across functional protein interaction networks, with the most highly alkylation-susceptible proteins mapping to networks involved in cytoskeletal regulation. Proteins with lower damage susceptibility mapped to networks involved in protein synthesis and turnover and were alkylated only at electrophile concentrations that caused significant toxicity. Hierarchical susceptibility of proteome systems to alkylation may allow cells to survive sublethal damage while protecting critical cell functions.

  18. Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems*

    Science.gov (United States)

    Codreanu, Simona G.; Ullery, Jody C.; Zhu, Jing; Tallman, Keri A.; Beavers, William N.; Porter, Ned A.; Marnett, Lawrence J.; Zhang, Bing; Liebler, Daniel C.

    2014-01-01

    Protein alkylation by reactive electrophiles contributes to chemical toxicities and oxidative stress, but the functional impact of alkylation damage across proteomes is poorly understood. We used Click chemistry and shotgun proteomics to profile the accumulation of proteome damage in human cells treated with lipid electrophile probes. Protein target profiles revealed three damage susceptibility classes, as well as proteins that were highly resistant to alkylation. Damage occurred selectively across functional protein interaction networks, with the most highly alkylation-susceptible proteins mapping to networks involved in cytoskeletal regulation. Proteins with lower damage susceptibility mapped to networks involved in protein synthesis and turnover and were alkylated only at electrophile concentrations that caused significant toxicity. Hierarchical susceptibility of proteome systems to alkylation may allow cells to survive sublethal damage while protecting critical cell functions. PMID:24429493

  19. Standard-target calibration of an acoustic backscatter system

    Science.gov (United States)

    Foote, Kenneth G.; Martini, Marinna A.

    2010-01-01

    The standard-target method used to calibrate scientific echo sounders and other scientific sonars by a single, solid elastic sphere is being adapted to acoustic backscatter (ABS) systems. Its first application, to the AQUAscat 1000, is described. The on-axis sensitivity and directional properties of transducer beams at three operating frequencies, nominally 1, 2.5, and 4 MHz, have been determined using a 10-mm-diameter sphere of tungsten carbide with 6% cobalt binder. Preliminary results are reported for the 1-MHz transducer. Their application to measurements of suspended sediment made in situ with the same device is described. This will enable the data to be expressed directly in physical units of volume backscattering.

  20. Targeting Renin–Angiotensin System Against Alzheimer’s Disease

    Directory of Open Access Journals (Sweden)

    Abadi Kahsu Gebre

    2018-04-01

    Full Text Available Renin Angiotensin System (RAS is a hormonal system that regulates blood pressure and fluid balance through a coordinated action of renal, cardiovascular, and central nervous systems. In addition to its hemodynamic regulatory role, RAS involves in many brain activities, including memory acquisition and consolidation. This review has summarized the involvement of RAS in the pathology of Alzheimer’s disease (AD, and the outcomes of treatment with RAS inhibitors. We have discussed the effect of brain RAS in the amyloid plaque (Aβ deposition, oxidative stress, neuroinflammation, and vascular pathology which are directly and indirectly associated with AD. Angiotensin II (AngII via AT1 receptor is reported to increase brain Aβ level via different mechanisms including increasing amyloid precursor protein (APP mRNA, β-secretase activity, and presenilin expression. Similarly, it was associated with tau phosphorylation, and reactive oxygen species generation. However, these effects are counterbalanced by Ang II mediated AT2 signaling. The protective effect observed with angiotensin receptor blockers (ARBs and angiotensin converting enzyme inhibitors (ACEIs could be as the result of inhibition of Ang II signaling. ARBs also offer additional benefit by shifting the effect of Ang II toward AT2 receptor. To conclude, targeting RAS in the brain may benefit patients with AD though it still requires further in depth understanding.

  1. System dynamic analyses on the JKJ mercury target and cold moderator systems

    International Nuclear Information System (INIS)

    Takahashi, Toshio; Kaminaga, Masanori; Kinoshita, Hidetaka; Aso, Tomokazu; Haga, Katsuhiro; Hino, Ryutaro

    2001-01-01

    The temperature responses of major points in a mercury target cooling system and in a cold moderator system of JKJ (JAERI/KEK Joint Project) were simulated by the analytical code MATLAB (SIMULINK). As a result, it was made clear that non-control of mercury temperature is the best way to control the mercury target cooling system. If the mercury temperature of the system is controlled by the PID control system using an outlet temperature of heat exchanger, the PID control system shows the characteristics of an on-off control system, and the temperature cannot be controlled. Analytical results also showed that mercury temperature remained below the boiling point of 356degC under 0.1 MPa during a transient at one cooling pump trip. Analytical results for the cold moderator system showed that the outlet temperature of cold moderator vessels could be kept within a temperature range of 1 k during steady-state conditions. (author)

  2. 20 CFR 670.535 - Are Job Corps centers required to establish behavior management systems?

    Science.gov (United States)

    2010-04-01

    ... behavior management systems? 670.535 Section 670.535 Employees' Benefits EMPLOYMENT AND TRAINING... systems? (a) Yes, each Job Corps center must establish and maintain its own student incentives system to encourage and reward students' accomplishments. (b) The Job Corps center must establish and maintain a...

  3. Real-Time Data Processing Systems and Products at the Alaska Earthquake Information Center

    Science.gov (United States)

    Ruppert, N. A.; Hansen, R. A.

    2007-05-01

    The Alaska Earthquake Information Center (AEIC) receives data from over 400 seismic sites located within the state boundaries and the surrounding regions and serves as a regional data center. In 2007, the AEIC reported ~20,000 seismic events, with the largest event of M6.6 in Andreanof Islands. The real-time earthquake detection and data processing systems at AEIC are based on the Antelope system from BRTT, Inc. This modular and extensible processing platform allows an integrated system complete from data acquisition to catalog production. Multiple additional modules constructed with the Antelope toolbox have been developed to fit particular needs of the AEIC. The real-time earthquake locations and magnitudes are determined within 2-5 minutes of the event occurrence. AEIC maintains a 24/7 seismologist-on-duty schedule. Earthquake alarms are based on the real- time earthquake detections. Significant events are reviewed by the seismologist on duty within 30 minutes of the occurrence with information releases issued for significant events. This information is disseminated immediately via the AEIC website, ANSS website via QDDS submissions, through e-mail, cell phone and pager notifications, via fax broadcasts and recorded voice-mail messages. In addition, automatic regional moment tensors are determined for events with M>=4.0. This information is posted on the public website. ShakeMaps are being calculated in real-time with the information currently accessible via a password-protected website. AEIC is designing an alarm system targeted for the critical lifeline operations in Alaska. AEIC maintains an extensive computer network to provide adequate support for data processing and archival. For real-time processing, AEIC operates two identical, interoperable computer systems in parallel.

  4. It is time to talk about people: a human-centered healthcare system

    Directory of Open Access Journals (Sweden)

    Borgi Lea

    2010-11-01

    Full Text Available Abstract Examining vulnerabilities within our current healthcare system we propose borrowing two tools from the fields of engineering and design: a Reason's system approach 1 and b User-centered design 23. Both approaches are human-centered in that they consider common patterns of human behavior when analyzing systems to identify problems and generate solutions. This paper examines these two human-centered approaches in the context of healthcare. We argue that maintaining a human-centered orientation in clinical care, research, training, and governance is critical to the evolution of an effective and sustainable healthcare system.

  5. National Ignition Facility Cryogenic Target Systems Interim Management Plan

    International Nuclear Information System (INIS)

    Warner, B

    2002-01-01

    Restricted availability of funding has had an adverse impact, unforeseen at the time of the original decision to projectize the National Ignition Facility (NIF) Cryogenic Target Handling Systems (NCTS) Program, on the planning and initiation of these efforts. The purpose of this document is to provide an interim project management plan describing the organizational structure and management processes currently in place for NCTS. Preparation of a Program Execution Plan (PEP) for NCTS has been initiated, and a current draft is provided as Attachment 1 to this document. The National Ignition Facility is a multi-megajoule laser facility being constructed at Lawrence Livermore National Laboratory (LLNL) by the National Nuclear Security Administration (NNSA) in the Department of Energy (DOE). Its primary mission is to support the Stockpile Stewardship Program (SSP) by performing experiments studying weapons physics, including fusion ignition. NIF also supports the missions of weapons effects, inertial fusion energy, and basic science in high-energy-density physics. NIF will be operated by LLNL under contract to the University of California (UC) as a national user facility. NIF is a low-hazard, radiological facility, and its operation will meet all applicable federal, state, and local Environmental Safety and Health (ES and H) requirements. The NCTS Interim Management Plan provides a summary of primary design criteria and functional requirements, current organizational structure, tracking and reporting procedures, and current planning estimates of project scope, cost, and schedule. The NIF Director controls the NIF Cryogenic Target Systems Interim Management Plan. Overall scope content and execution schedules for the High Energy Density Physics Campaign (SSP Campaign 10) are currently undergoing rebaselining and will be brought into alignment with resources expected to be available throughout the NNSA Future Years National Security Plan (FYNSP). The revised schedule for

  6. Development of the HERA-Β-target-control system and study of target operation at the HERA storage ring

    International Nuclear Information System (INIS)

    Issever, S.

    2001-03-01

    The HERA-B experiment investigates the physics of heavy quarks, which are produced in pN reactions of the 920 GeV protons of HERA with the HERA-B internal fixed target. It consists out of eight wires, which surround the proton beam from four sides and is a high luminosity particle source. As being the closest mechanical device to the proton beam, it has to be operated very carefully and thus needs a secure and automatic control system, which additionally must be efficient and reliable to guarantee an efficient HERA-B data taking. The implementation of the target control system and its performance as well as dedicated studies of target-beam physics are presented. These include the measurement of the aperture limitation, usual target operational position, target efficiency, target independent proton loss in HERA and the scrape velocity of the target. The source of rate fluctuations is investigated in detail; among many dependencies environmental noise has a major impact on the rate fluctuations. Further studies include the analysis of beam position fluctuations and its correlation to the rate fluctuations; the rate changes about a factor of 2, if the beam is changing its position by 10 μm. This rate sensitivity is also verified directly by means of step function measurements. Furthermore the step function measurements can be used to study target-beam dynamics on time scales as short as a second. Experiments to reduce the rate sensitivity - the so called beam tail shaping measurements - are presented as well. During target operation a current, which is proportional to the interaction rate, is measured and used to determine the rate of each single wire. It is shown, that the source of this current is delta electron production. Finally the multiwire performance of the target control system is presented. (orig.)

  7. Solid expandable systems put deepwater targets within reach

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Roca, Eduardo [Enventure Global Technology L.L.C., Houston, TX (United States). Latin America; Fristch, Jerry [Enventure Global Technology L.L.C., Houston, TX (United States)

    2008-07-01

    Enabling technologies that take drilling operations to deeper objectives have made a significant impact on the practicality of many projects, especially deep water offshore targets. Increasing vertical depth and lateral reach requires adequate hole size to attain the desired objectives of the well bore. Solid expandable technology can maintain and retain hole size to address both the physical limitations and the economic feasibility of deep water operations. With each and every casing point, the potential for adequate hole size at total depth (TD) decreases. Solid expandable open hole liners and single-diameter systems reduce and eliminate, respectively, the well bore tapering that dictates hole size at TD and subsequent completion size. Successful mitigation of this tapering, whether through the entire well bore or through select zones, enables operators to gain access to previously unreachable reserves. Solid expandable systems have proven to be reliable and effective with over 1,000 installations in a myriad of conditions and environments worldwide. To date, over 115 of those applications have been in deep water environments. The current operating envelope for solid expandable systems include the deepest installation at {approx}28,750 ft (8,763 m) and the longest at 6,867 ft (2,083 m) in water depth over 3,150 ft (960 m). This record-length application consisted of an open hole liner installed and expanded in a single run. This paper will discuss the effectiveness of solid expandable systems in deep water operations and how the technology brings value to offshore projects especially when planned into the initial design. Case histories will be used to further illustrate the features, advantages, and benefits of expandable technology. In addition, this paper will examine the state of the solid expandable technology and its continuing evolution to provide even more drilling solutions. (author)

  8. Human-centered design of the human-system interfaces of medical equipment: thyroid uptake system

    International Nuclear Information System (INIS)

    Monteiro, Jonathan K.R.; Farias, Marcos S.; Santos, Isaac J.A. Luquetti; Monteiro, Beany G.

    2013-01-01

    Technology plays an important role in modern medical centers, making healthcare increasingly complex, relying on complex technical equipment. This technical complexity is particularly noticeable in the nuclear medicine. Poorly design human-system interfaces can increase the risks for human error. The human-centered approach emphasizes the development of the equipment with a deep understanding of the users activities, current work practices, needs and abilities of the users. An important concept of human-centered design is that the ease-of-use of the equipment can be ensured only if users are actively incorporated in all phases of the life cycle of design process. Representative groups of users are exposed to the equipment at various stages in development, in a variety of testing, evaluation and interviewing situations. The users feedback obtained is then used to refine the design, with the result serving as input to the next interaction of design process. The limits of the approach are that the users cannot address any particular future needs without prior experience or knowledge about the equipment operation. The aim of this paper is to present a methodological framework that contributes to the design of the human-system interfaces, through an approach related to the users and their activities. A case study is described in which the methodological framework is being applied in development of new human-system interfaces of the thyroid uptake system. (author)

  9. Gene design, cloning and protein-expression methods for high-value targets at the Seattle Structural Genomics Center for Infectious Disease

    International Nuclear Information System (INIS)

    Raymond, Amy; Haffner, Taryn; Ng, Nathan; Lorimer, Don; Staker, Bart; Stewart, Lance

    2011-01-01

    An overview of one salvage strategy for high-value SSGCID targets is given. Any structural genomics endeavor, particularly ambitious ones such as the NIAID-funded Seattle Structural Genomics Center for Infectious Disease (SSGCID) and Center for Structural Genomics of Infectious Disease (CSGID), face technical challenges at all points of the production pipeline. One salvage strategy employed by SSGCID is combined gene engineering and structure-guided construct design to overcome challenges at the levels of protein expression and protein crystallization. Multiple constructs of each target are cloned in parallel using Polymerase Incomplete Primer Extension cloning and small-scale expressions of these are rapidly analyzed by capillary electrophoresis. Using the methods reported here, which have proven particularly useful for high-value targets, otherwise intractable targets can be resolved

  10. Aliskiren targets multiple systems to alleviate cancer cachexia.

    Science.gov (United States)

    Wang, Chaoyi; Guo, Dunwei; Wang, Qiang; You, Song; Qiao, Zhongpeng; Liu, Yong; Dai, Hang; Tang, Hua

    2016-11-01

    To examine the effects of aliskiren, a small-molecule renin inhibitor, on cancer cachexia and to explore the underlying mechanisms. A cancer cachexia model was established by subcutaneously injecting C26 mouse colon carcinoma cells into isogenic BALB/c mice. Aliskiren was administered intragastrically [10 mg/kg body weight (BW)] on day 5 (as a preventive strategy, AP group) or on day 12 (as a therapeutic strategy, AT group) after C26 injection. Mice that received no C26 injection (healthy controls, HC group) or only C26 injection but not aliskiren (cancer, CA group) were used as controls. BW, tumor growth, whole body functions, and survival were monitored daily in half of the mice in each group, whereas serum, tumors, and gastrocnemius muscles were harvested from the other mice after sacrifice on day 20 for further analysis. Aliskiren significantly alleviated multiple cachexia‑associated symptoms, including BW loss, tumor burden, muscle wasting, muscular dysfunction, and shortened survival. On the molecular level, aliskiren antagonized cachexia‑induced activation of the renin‑angiotensin system (RAS), systematic and muscular inflammation, oxidative stress, and autophagy‑lysosome as well as ubiquitin‑proteasome stimulation. In addition, early administration of aliskiren before cachexia development (AP group) resulted in more robust effects in alleviating cachexia or targeting underlying mechanisms than administration after cachexia development (AT group). Aliskiren exhibited potent anti‑cachexia activities. These activities were achieved through the targeting of at least four mechanisms underlying cachexia development: RAS activation, increase in systematic inflammation, upregulation of oxidative stress, and stimulation of autophagy-lysosome pathway (ALP) and ubiquitin-proteasome pathway (UPP).

  11. Plant Resources Center and the Vietnamese genebank system

    Science.gov (United States)

    The highly diverse floristic composition of Vietnam has been recognized as a center of angiosperm expansion and crop biodiversity. The broad range of climatic environments include habitats from tropical and subtropical, to temperate and alpine flora. The human component of the country includes 54 et...

  12. Buying Program of the Standard Automated Materiel Management System. Automated Small Purchase System: Defense Supply Center Philadelphia

    National Research Council Canada - National Science Library

    2001-01-01

    The Standard Automated Materiel Management System Automated Small Purchase System is a fully automated micro-purchases system used by the General and Industrial Directorate at the Defense Supply Center Philadelphia...

  13. Targeted therapy for Hodgkin lymphoma and systemic anaplastic large cell lymphoma: focus on brentuximab vedotin

    Directory of Open Access Journals (Sweden)

    Chen X

    2013-12-01

    Full Text Available Xueyan Chen, Lorinda A Soma, Jonathan R FrommDepartment of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USAAbstract: Despite the relative success of chemotherapy for Hodgkin lymphoma (HL and systemic anaplastic large cell lymphoma (ALCL, novel therapeutic agents are needed for refractory or relapsed patients. Targeted immunotherapy has emerged as a novel treatment option for these patients. Although unconjugated anti-cluster of differentiation (CD30 antibodies showed minimal antitumor activity in early clinical trials, development of antibody–drug conjugates (ADCs appears promising. Brentuximab vedotin is an ADC composed of an anti-CD30 antibody linked to a potent microtubule-disrupting agent monomethyl auristatin E (MMAE. It has the ability to target CD30-positive tumor cells and, once bound to CD30, brentuximab vedotin is internalized and MMAE is released to induce cell cycle arrest and apoptosis. In two phase II trials, objective response was reported in 75% and 86% of patients with refractory or relapsed HL and systemic ALCL, respectively, with an acceptable toxicity profile. Based on these studies, the US Food and Drug Administration (FDA granted accelerated approval of brentuximab vedotin in August 2011 for the treatment of refractory and relapsed HL and ALCL. We review the key characteristics of brentuximab vedotin, clinical data supporting its therapeutic efficacy, and current ongoing trials to explore its utility in other CD30-positive malignancies.Keywords: classical Hodgkin lymphoma, systemic anaplastic large cell lymphoma, CD30, brentuximab vedotin, SGN-35

  14. System of automatic control over data Acquisition and Transmission to IGR NNC RK Data Center

    International Nuclear Information System (INIS)

    Komarov, I.I.; Gordienko, D.D.; Kunakov, A.V.

    2005-01-01

    Automated system for seismic and acoustic data acquisition and transmission in real time was established in Data Center IGR NNC RK, which functions very successively. The system monitors quality and volume of acquired information and also controls the status of the system and communication channels. Statistical data on system operation are accumulated in created database. Information on system status is reflected on the Center Web page. (author)

  15. Space Operations Center system analysis. Volume 3, book 2: SOC system definition report, revision A

    Science.gov (United States)

    1982-01-01

    The Space Operations Center (SOC) orbital space station program operations are described. A work breakdown structure for the general purpose support equipment, construction and transportation support, and resupply and logistics support systems is given. The basis for the design of each element is presented, and a mass estimate for each element supplied. The SOC build-up operation, construction, flight support, and satellite servicing operations are described. Detailed programmatics and cost analysis are presented.

  16. [Outline and effectiveness of support system in the surgical center by supply, processing and distribution center (SPD)].

    Science.gov (United States)

    Ito, Nobuko; Chinzei, Mieko; Fujiwara, Haruko; Usui, Hisako; Hanaoka, Kazuo; Saitoh, Eisho

    2006-04-01

    Supply, Processing and Distribution system had been introduced to surgical center (the University of Tokyo Hospital) since October of 2002. This system had reduced stock for medicine and materials and decreased medical cost dramatically. We designed some kits for therapeutic drugs related to anesthesia. They were prepared for general anesthesia, epidural and spinal anesthesia, and cardiovascular anesthesia, respectively. One kit had been used for one patient, and new kits were prepared in the anesthesia preparation room by pharmaceutical department staffs. Equipment, for general anesthesia as well as epidural and spinal anesthesia, and central catheter set were also designed and provided for each patient by SPD system. According to the questionnaire of anesthesia residents before and after introduction of SPD system, the time spent for anesthesia preparation had been reduced and 92.3% residents had answered that preparation for anesthesia on the previous day was getting easier. Most of the anesthesia residents had been less stressed after introduction of SPD system. Beside the dramatic economical effect, coordination with SPD system and pharmaceutical department reduced anesthesia preparation time and stress of the staff. Introduction of Support system of SPD to surgical center is important for safe and effective management of operating rooms.

  17. A bronchoscopic navigation system using bronchoscope center calibration for accurate registration of electromagnetic tracker and CT volume without markers

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Xiongbiao, E-mail: xiongbiao.luo@gmail.com [Robarts Research Institute, Western University, London, Ontario N6A 5K8 (Canada)

    2014-06-15

    Purpose: Various bronchoscopic navigation systems are developed for diagnosis, staging, and treatment of lung and bronchus cancers. To construct electromagnetically navigated bronchoscopy systems, registration of preoperative images and an electromagnetic tracker must be performed. This paper proposes a new marker-free registration method, which uses the centerlines of the bronchial tree and the center of a bronchoscope tip where an electromagnetic sensor is attached, to align preoperative images and electromagnetic tracker systems. Methods: The chest computed tomography (CT) volume (preoperative images) was segmented to extract the bronchial centerlines. An electromagnetic sensor was fixed at the bronchoscope tip surface. A model was designed and printed using a 3D printer to calibrate the relationship between the fixed sensor and the bronchoscope tip center. For each sensor measurement that includes sensor position and orientation information, its corresponding bronchoscope tip center position was calculated. By minimizing the distance between each bronchoscope tip center position and the bronchial centerlines, the spatial alignment of the electromagnetic tracker system and the CT volume was determined. After obtaining the spatial alignment, an electromagnetic navigation bronchoscopy system was established to real-timely track or locate a bronchoscope inside the bronchial tree during bronchoscopic examinations. Results: The electromagnetic navigation bronchoscopy system was validated on a dynamic bronchial phantom that can simulate respiratory motion with a breath rate range of 0–10 min{sup −1}. The fiducial and target registration errors of this navigation system were evaluated. The average fiducial registration error was reduced from 8.7 to 6.6 mm. The average target registration error, which indicates all tracked or navigated bronchoscope position accuracy, was much reduced from 6.8 to 4.5 mm compared to previous registration methods. Conclusions: An

  18. A bronchoscopic navigation system using bronchoscope center calibration for accurate registration of electromagnetic tracker and CT volume without markers

    International Nuclear Information System (INIS)

    Luo, Xiongbiao

    2014-01-01

    Purpose: Various bronchoscopic navigation systems are developed for diagnosis, staging, and treatment of lung and bronchus cancers. To construct electromagnetically navigated bronchoscopy systems, registration of preoperative images and an electromagnetic tracker must be performed. This paper proposes a new marker-free registration method, which uses the centerlines of the bronchial tree and the center of a bronchoscope tip where an electromagnetic sensor is attached, to align preoperative images and electromagnetic tracker systems. Methods: The chest computed tomography (CT) volume (preoperative images) was segmented to extract the bronchial centerlines. An electromagnetic sensor was fixed at the bronchoscope tip surface. A model was designed and printed using a 3D printer to calibrate the relationship between the fixed sensor and the bronchoscope tip center. For each sensor measurement that includes sensor position and orientation information, its corresponding bronchoscope tip center position was calculated. By minimizing the distance between each bronchoscope tip center position and the bronchial centerlines, the spatial alignment of the electromagnetic tracker system and the CT volume was determined. After obtaining the spatial alignment, an electromagnetic navigation bronchoscopy system was established to real-timely track or locate a bronchoscope inside the bronchial tree during bronchoscopic examinations. Results: The electromagnetic navigation bronchoscopy system was validated on a dynamic bronchial phantom that can simulate respiratory motion with a breath rate range of 0–10 min −1 . The fiducial and target registration errors of this navigation system were evaluated. The average fiducial registration error was reduced from 8.7 to 6.6 mm. The average target registration error, which indicates all tracked or navigated bronchoscope position accuracy, was much reduced from 6.8 to 4.5 mm compared to previous registration methods. Conclusions: An

  19. Multi-target-qubit unconventional geometric phase gate in a multi-cavity system.

    Science.gov (United States)

    Liu, Tong; Cao, Xiao-Zhi; Su, Qi-Ping; Xiong, Shao-Jie; Yang, Chui-Ping

    2016-02-22

    Cavity-based large scale quantum information processing (QIP) may involve multiple cavities and require performing various quantum logic operations on qubits distributed in different cavities. Geometric-phase-based quantum computing has drawn much attention recently, which offers advantages against inaccuracies and local fluctuations. In addition, multiqubit gates are particularly appealing and play important roles in QIP. We here present a simple and efficient scheme for realizing a multi-target-qubit unconventional geometric phase gate in a multi-cavity system. This multiqubit phase gate has a common control qubit but different target qubits distributed in different cavities, which can be achieved using a single-step operation. The gate operation time is independent of the number of qubits and only two levels for each qubit are needed. This multiqubit gate is generic, e.g., by performing single-qubit operations, it can be converted into two types of significant multi-target-qubit phase gates useful in QIP. The proposal is quite general, which can be used to accomplish the same task for a general type of qubits such as atoms, NV centers, quantum dots, and superconducting qubits.

  20. Evaluating energy saving system of data centers based on AHP and fuzzy comprehensive evaluation model

    Science.gov (United States)

    Jiang, Yingni

    2018-03-01

    Due to the high energy consumption of communication, energy saving of data centers must be enforced. But the lack of evaluation mechanisms has restrained the process on energy saving construction of data centers. In this paper, energy saving evaluation index system of data centers was constructed on the basis of clarifying the influence factors. Based on the evaluation index system, analytical hierarchy process was used to determine the weights of the evaluation indexes. Subsequently, a three-grade fuzzy comprehensive evaluation model was constructed to evaluate the energy saving system of data centers.

  1. Staff roster for 1979: National Center for Analysis of Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    This publication is a compilation of resumes from the current staff of the National Center for Analysis of Energy Systems. The Center, founded in January 1976, is one of four areas within the Department of Energy and Environment at Brookhaven National Laboratory. The emphasis of programs at the Center is on energy policy and planning studies at the regional, national, and international levels, involving quantitative, interdisciplinary studies of the technological, economic, social, and environmental aspects of energy systems. To perform these studies the Center has assembled a staff of experts in the areas of science, technology, economics planning, health and safety, information systems, and quantitative analysis.

  2. The Patient-Centered Medical Home Neighbor: A Critical Concept for a Redesigned Healthcare Delivery System

    Science.gov (United States)

    2011-01-25

    Sharing Knowledge: Achieving Breakthrough Performance 2010 Military Health System Conference The Patient -Centered Medical Home Neighbor: A Critical...DATE 25 JAN 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE The Patient -Centered Medical Home Neighbor: A...Conference What is the Patient -Centered Medical Home?  …a vision of health care as it should be  …a framework for organizing systems of care at both the

  3. Automatic target alignment of the Helios laser system

    International Nuclear Information System (INIS)

    Liberman, I.; Viswanathan, V.K.; Klein, M.; Seery, B.D.

    1980-01-01

    An automatic target-alignment technique for the Helios laser facility is reported and verified experimentally. The desired alignment condition is completely described by an autocollimation test. A computer program examines the autocollimated return pattern from the surrogate target and correctly describes any changes required in mirror orientation to yield optimum targe alignment with either aberrated or misaligned beams. Automated on-line target alignment is thus shown to be feasible

  4. The Design of HVAC System in the Conventional Facility of Proton Accelerator Research Center

    International Nuclear Information System (INIS)

    Jeon, G. P.; Kim, J. Y.; Choi, B. H.

    2007-01-01

    The HVAC systems for conventional facility of Proton Accelerator Research Center consist of 3 systems : accelerator building HVAC system, beam application building HVAC system and miscellaneous HVAC system. We designed accelerator building HVAC system and beam application research area HVAC system in the conventional facilities of Proton Accelerator research center. Accelerator building HVAC system is divided into accelerator tunnel area, klystron area, klystron gallery area, accelerator assembly area. Also, Beam application research area HVAC system is divided into those of beam experimental hall, accelerator control area, beam application research area and Ion beam application building. In this paper, We described system design requirements and explained system configuration for each systems. We presented operation scenario of HVAC system in the Conventional Facility of Proton Accelerator Research Center

  5. Gas injection system in the Tara center cell

    International Nuclear Information System (INIS)

    Brau, K.; Post, R.S.; Sevillano, E.

    1985-11-01

    Precise control of the gas fueling is essential to the successful operation of tandem mirror plasmas. Improper choice of fueling location, magnetic geometry, and gas injection rates can prevent potential and thermal barrier formation, as well as reduce the energy confinement time. In designing the new gas injection configuration for the Tara center cell, the following issues were addressed: RF potential barriers, gas leakage, and charge exchange recombination. 2 refs., 6 figs

  6. Muon-catalyzed fusion experiment target and detector system. Preliminary design report

    International Nuclear Information System (INIS)

    Jones, S.E.; Watts, K.D.; Caffrey, A.J.; Walter, J.B.

    1982-03-01

    We present detailed plans for the target and particle detector systems for the muon-catalyzed fusion experiment. Requirements imposed on the target vessel by experimental conditions and safety considerations are delineated. Preliminary designs for the target vessel capsule and secondary containment vessel have been developed which meet these requirements. In addition, the particle detection system is outlined, including associated fast electronics and on-line data acquisition. Computer programs developed to study the target and detector system designs are described

  7. Review of ISOL target-ion-source systems

    CERN Document Server

    Kirchner, R

    2003-01-01

    Any review of target-ion-source systems (TISS) is necessarily a variation of the ISOL-theme 'efficient, fast, selective'. In the first part, more than 30 years of TISS development are examined in view of these key characteristics. By looking at the lines of development that were successful, at the lines that were abandoned (partly for good, partly for less good reasons), the lines with the most promising perspectives emerge. The second part deals with on-line chemistry in the TISS and its possibly double benefits: enhanced selectivity or increased separation speed, or both in favourable cases, as the relatively new sulfide chemistry. For the group-IVa-elements germanium and tin, the separation as sulfide-ions does not only suppress strongly the contamination by the neighbouring elements. It also reduces the effusion part of the release by orders of magnitude to the level of the intrinsic delay caused by molecular flow. The homologue chemistry is likely to work for silicon, but not for lead. While selectivity ...

  8. Programmable Ultrasonic Sensing System for Targeted Spraying in Orchards

    Directory of Open Access Journals (Sweden)

    Marko Hočevar

    2012-11-01

    Full Text Available This research demonstrates the basic elements of a prototype automated orchard sprayer which delivers pesticide spray selectively with respect to the characteristics of the targets. The density of an apple tree canopy was detected by PROWAVE 400EP250 ultrasound sensors controlled by a Cypress PSOC CY8C29466 microcontroller. The ultrasound signal was processed with an embedded computer built around a LPC1343 microcontroller and fed in real time to electro-magnetic valves which open/close spraying nozzles in relation to the canopy structure. The analysis focuses on the detection of appropriate thresholds on 15 cm ultrasound bands, which correspond to maximal response to tree density, and this was selected for accurate spraying guidance. Evaluation of the system was performed in an apple orchard by detecting deposits of tartrazine dye (TD on apple leaves. The employment of programmable microcontrollers and electro-magnetic valves decreased the amount of spray delivered by up to 48.15%. In contrast, the reduction of TD was only up to 37.7% at some positions within the tree crown and 65.1% in the gaps between trees. For all these reasons, this concept of precise orchard spraying can contribute to a reduction of costs and environmental pollution, while obtaining similar or even better leaf deposits.

  9. Programmable Ultrasonic Sensing System for Targeted Spraying in Orchards

    Science.gov (United States)

    Stajnko, Denis; Berk, Peter; Lešnik, Mario; Jejčič, Viktor; Lakota, Miran; Štrancar, Andrej; Hočevar, Marko; Rakun, Jurij

    2012-01-01

    This research demonstrates the basic elements of a prototype automated orchard sprayer which delivers pesticide spray selectively with respect to the characteristics of the targets. The density of an apple tree canopy was detected by PROWAVE 400EP250 ultrasound sensors controlled by a Cypress PSOC CY8C29466 microcontroller. The ultrasound signal was processed with an embedded computer built around a LPC1343 microcontroller and fed in real time to electro-magnetic valves which open/close spraying nozzles in relation to the canopy structure. The analysis focuses on the detection of appropriate thresholds on 15 cm ultrasound bands, which correspond to maximal response to tree density, and this was selected for accurate spraying guidance. Evaluation of the system was performed in an apple orchard by detecting deposits of tartrazine dye (TD) on apple leaves. The employment of programmable microcontrollers and electro-magnetic valves decreased the amount of spray delivered by up to 48.15%. In contrast, the reduction of TD was only up to 37.7% at some positions within the tree crown and 65.1% in the gaps between trees. For all these reasons, this concept of precise orchard spraying can contribute to a reduction of costs and environmental pollution, while obtaining similar or even better leaf deposits. PMID:23202220

  10. 78 FR 74163 - Harrison Medical Center, a Subsidiary of Franciscan Health System Bremerton, Washington; Notice...

    Science.gov (United States)

    2013-12-10

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-83,070] Harrison Medical Center, a Subsidiary of Franciscan Health System Bremerton, Washington; Notice of Negative Determination... workers of Harrison Medical Center, a subsidiary of Franciscan Health System, Bremerton, Washington...

  11. Application of NASA Kennedy Space Center system assurance analysis methodology to nuclear power plant systems designs

    International Nuclear Information System (INIS)

    Page, D.W.

    1985-01-01

    The Kennedy Space Center (KSC) entered into an agreement with the Nuclear Regulatory Commission (NRC) to conduct a study to demonstrate the feasibility and practicality of applying the KSC System Assurance Analysis (SAA) methodology to nuclear power plant systems designs. In joint meetings of KSC and Duke Power personnel, an agreement was made to select to CATAWBA systems, the Containment Spray System and the Residual Heat Removal System, for the analyses. Duke Power provided KSC with a full set a Final Safety Analysis Reports as well as schematics for the two systems. During Phase I of the study the reliability analyses of the SAA were performed. During Phase II the hazard analyses were performed. The final product of Phase II is a handbook for implementing the SAA methodology into nuclear power plant systems designs. The purpose of this paper is to describe the SAA methodology as it applies to nuclear power plant systems designs and to discuss the feasibility of its application. The conclusion is drawn that nuclear power plant systems and aerospace ground support systems are similar in complexity and design and share common safety and reliability goals. The SAA methodology is readily adaptable to nuclear power plant designs because of it's practical application of existing and well known safety and reliability analytical techniques tied to an effective management information system

  12. Magneto-mechanical trapping systems for biological target detection

    International Nuclear Information System (INIS)

    Li, Fuquan; Kodzius, Rimantas; Gooneratne, Chinthaka P.; Foulds, Ian G.; Kosel, Jürgen

    2014-01-01

    We demonstrate a magnetic microsystem capable of detecting nucleic acids via the size difference between bare magnetic beads and bead compounds. The bead compounds are formed through linking nonmagnetic beads and magnetic beads by the target nucleic acids. The system comprises a tunnel magneto-resistive (TMR) sensor, a trapping well, and a bead-concentrator. The TMR sensor detects the stray field of magnetic beads inside the trapping well, while the sensor output depends on the number of beads. The size of the bead compounds is larger than that of bare magnetic beads, and fewer magnetic beads are required to fill the trapping well. The bead-concentrator, in turn, is capable of filling the trap in a controlled fashion and so to shorten the assay time. The bead-concentrator includes conducting loops surrounding the trapping well and a conducting line underneath. The central conducting line serves to attract magnetic beads in the trapping well and provides a magnetic field to magnetize them so to make them detectable by the TMR sensor. This system excels by its simplicity in that the DNA is incubated with magnetic and nonmagnetic beads, and the solution is then applied to the chip and analyzed in a single step. In current experiments, a signal-to-noise ratio of 40.3 dB was obtained for a solution containing 20.8 nM of DNA. The sensitivity and applicability of this method can be controlled by the size or concentration of the nonmagnetic bead, or by the dimension of the trapping well. (author)

  13. Magneto-mechanical trapping systems for biological target detection

    KAUST Repository

    Li, Fuquan

    2014-03-29

    We demonstrate a magnetic microsystem capable of detecting nucleic acids via the size difference between bare magnetic beads and bead compounds. The bead compounds are formed through linking nonmagnetic beads and magnetic beads by the target nucleic acids. The system comprises a tunnel magneto-resistive (TMR) sensor, a trapping well, and a bead-concentrator. The TMR sensor detects the stray field of magnetic beads inside the trapping well, while the sensor output depends on the number of beads. The size of the bead compounds is larger than that of bare magnetic beads, and fewer magnetic beads are required to fill the trapping well. The bead-concentrator, in turn, is capable of filling the trap in a controlled fashion and so to shorten the assay time. The bead-concentrator includes conducting loops surrounding the trapping well and a conducting line underneath. The central conducting line serves to attract magnetic beads in the trapping well and provides a magnetic field to magnetize them so to make them detectable by the TMR sensor. This system excels by its simplicity in that the DNA is incubated with magnetic and nonmagnetic beads, and the solution is then applied to the chip and analyzed in a single step. In current experiments, a signal-to-noise ratio of 40.3 dB was obtained for a solution containing 20.8 nM of DNA. The sensitivity and applicability of this method can be controlled by the size or concentration of the nonmagnetic bead, or by the dimension of the trapping well.

  14. Baselining the New GSFC Information Systems Center: The Foundation for Verifiable Software Process Improvement

    Science.gov (United States)

    Parra, A.; Schultz, D.; Boger, J.; Condon, S.; Webby, R.; Morisio, M.; Yakimovich, D.; Carver, J.; Stark, M.; Basili, V.; hide

    1999-01-01

    This paper describes a study performed at the Information System Center (ISC) in NASA Goddard Space Flight Center. The ISC was set up in 1998 as a core competence center in information technology. The study aims at characterizing people, processes and products of the new center, to provide a basis for proposing improvement actions and comparing the center before and after these actions have been performed. The paper presents the ISC, goals and methods of the study, results and suggestions for improvement, through the branch-level portion of this baselining effort.

  15. From product centered design to value centered design: understanding the value-system

    DEFF Research Database (Denmark)

    Randmaa, Merili; Howard, Thomas J.; Otto, T.

    Product design has focused on different parameters through history- design for usability, design for manufacturing, design for assembly etc. Today, as the products get bundled with service, it is important to interconnect product, service and business model design to create synergy effect and offer...... more value for the customer for less eford. Value and understanding the value-system needs to be in the focus of business strategy. Value can be created, exchanged and perceived. It can be tangible (physical products, money) or intangible (information, experience, relationships, service). Creating...... value is usually a co-creation process, where customers, suppliers and manufacturers all have their part. This paper describes a paradigm shift towards value-based thinking and proposes a new methodology for understanding and analysing the value system....

  16. Solar heating and hot water system installed at the Senior Citizen Center, Huntsville, Alabama

    Science.gov (United States)

    1980-01-01

    The solar energy system installed at the Huntsville Senior Citizen Center is described. Detailed drawings of the complete system and discussions of the planning, the hardware, recommendations, and other pertinent information are presented.

  17. Target tracking system based on preliminary and precise two-stage compound cameras

    Science.gov (United States)

    Shen, Yiyan; Hu, Ruolan; She, Jun; Luo, Yiming; Zhou, Jie

    2018-02-01

    Early detection of goals and high-precision of target tracking is two important performance indicators which need to be balanced in actual target search tracking system. This paper proposed a target tracking system with preliminary and precise two - stage compound. This system using a large field of view to achieve the target search. After the target was searched and confirmed, switch into a small field of view for two field of view target tracking. In this system, an appropriate filed switching strategy is the key to achieve tracking. At the same time, two groups PID parameters are add into the system to reduce tracking error. This combination way with preliminary and precise two-stage compound can extend the scope of the target and improve the target tracking accuracy and this method has practical value.

  18. Heat pump centered integrated community energy systems: system development. Georgia Institute of Technology final report

    Energy Technology Data Exchange (ETDEWEB)

    Wade, D.W.; Trammell, B.C.; Dixit, B.S.; McCurry, D.C.; Rindt, B.A.

    1979-12-01

    Heat Pump Centered-Integrated Community Energy Systems (HP-ICES) show the promise of utilizing low-grade thermal energy for low-quality energy requirements such as space heating and cooling. The Heat Pump - Wastewater Heat Recovery (HP-WHR) scheme is one approach to an HP-ICES that proposes to reclaim low-grade thermal energy from a community's wastewater effluent. This report develops the concept of an HP-WHR system, evaluates the potential performance and economics of such a system, and examines the potential for application. A thermodynamic performance analysis of a hypothetical system projects an overall system Coefficient of Performance (C.O.P.) of from 2.181 to 2.264 for waste-water temperatures varying from 50/sup 0/F to 80/sup 0/F. Primary energy source savings from the nationwide implementation of this system is projected to be 6.0 QUADS-fuel oil, or 8.5 QUADS - natural gas, or 29.7 QUADS - coal for the period 1980 to 2000, depending upon the type and mix of conventional space conditioning systems which could be displaced with the HP-WHR system. Site-specific HP-WHR system designs are presented for two application communities in Georgia. Performance analyses for these systems project annual cycle system C.O.P.'s of 2.049 and 2.519. Economic analysis on the basis of a life cycle cost comparison shows one site-specific system design to be cost competitive in the immediate market with conventional residential and light commercial HVAC systems. The second site-specific system design is shown through a similar economic analysis to be more costly than conventional systems due mainly to the current low energy costs for natural gas. It is anticipated that, as energy costs escalate, this HP-WHR system will also approach the threshold of economic viability.

  19. Implementing the patient-centered medical home in complex adaptive systems: Becoming a relationship-centered patient-centered medical home.

    Science.gov (United States)

    Flieger, Signe Peterson

    This study explores the implementation experience of nine primary care practices becoming patient-centered medical homes (PCMH) as part of the New Hampshire Citizens Health Initiative Multi-Stakeholder Medical Home Pilot. The purpose of this study is to apply complex adaptive systems theory and relationship-centered organizations theory to explore how nine diverse primary care practices in New Hampshire implemented the PCMH model and to offer insights for how primary care practices can move from a structural PCMH to a relationship-centered PCMH. Eighty-three interviews were conducted with administrative and clinical staff at the nine pilot practices, payers, and conveners of the pilot between November and December 2011. The interviews were transcribed, coded, and analyzed using both a priori and emergent themes. Although there is value in the structural components of the PCMH (e.g., disease registries), these structures are not enough. Becoming a relationship-centered PCMH requires attention to reflection, sensemaking, learning, and collaboration. This can be facilitated by settings aside time for communication and relationship building through structured meetings about PCMH components as well as the implementation process itself. Moreover, team-based care offers a robust opportunity to move beyond the structures to focus on relationships and collaboration. (a) Recognize that PCMH implementation is not a linear process. (b) Implementing the PCMH from a structural perspective is not enough. Although the National Committee for Quality Assurance or other guidelines can offer guidance on the structural components of PCMH implementation, this should serve only as a starting point. (c) During implementation, set aside structured time for reflection and sensemaking. (d) Use team-based care as a cornerstone of transformation. Reflect on team structures and also interactions of the team members. Taking the time to reflect will facilitate greater sensemaking and learning and

  20. Information systems performance evaluation, introducing a two-level technique: Case study call centers

    Directory of Open Access Journals (Sweden)

    Hesham A. Baraka

    2015-03-01

    The objective of this paper was to introduce a new technique that can support decision makers in the call centers industry to evaluate, and analyze the performance of call centers. The technique presented is derived from the research done on measuring the success or failure of information systems. Two models are mainly adopted namely: the Delone and Mclean model first introduced in 1992 and the Design Reality Gap model introduced by Heeks in 2002. Two indices are defined to calculate the performance of the call center; the success index and the Gap Index. An evaluation tool has been developed to allow call centers managers to evaluate the performance of their call centers in a systematic analytical approach; the tool was applied on 4 call centers from different areas, simple applications such as food ordering, marketing, and sales, technical support systems, to more real time services such as the example of emergency control systems. Results showed the importance of using information systems models to evaluate complex systems as call centers. The models used allow identifying the dimensions for the call centers that are facing challenges, together with an identification of the individual indicators in these dimensions that are causing the poor performance of the call center.

  1. Unifying Human Centered Design and Systems Engineering for Human Systems Integration

    Science.gov (United States)

    Boy, Guy A.; McGovernNarkevicius, Jennifer

    2013-01-01

    Despite the holistic approach of systems engineering (SE), systems still fail, and sometimes spectacularly. Requirements, solutions and the world constantly evolve and are very difficult to keep current. SE requires more flexibility and new approaches to SE have to be developed to include creativity as an integral part and where the functions of people and technology are appropriately allocated within our highly interconnected complex organizations. Instead of disregarding complexity because it is too difficult to handle, we should take advantage of it, discovering behavioral attractors and the emerging properties that it generates. Human-centered design (HCD) provides the creativity factor that SE lacks. It promotes modeling and simulation from the early stages of design and throughout the life cycle of a product. Unifying HCD and SE will shape appropriate human-systems integration (HSI) and produce successful systems.

  2. Simulations of beam trajectory for position target optimization of extraction system output beams cyclotron proton Decy-13

    International Nuclear Information System (INIS)

    Idrus Abdul Kudus; Taufik

    2015-01-01

    Positioning and track simulation beam the cyclotron Decy-13 for laying optimization the target system have been done using lorentz force function and scilab 5.4.1 simulation. Magnetic field and electric field is calculated using Opera3D/Tosca as a simulation input. Used radio frequency is 77.66 MHz with the amplitude voltage is 40 kV is obtained energy 13 MeV. The result showed that the coordinates of the laying of the target system in a vacuum chamber is located at x = -389 mm and y = 445 mm with the width of the output beam is 10 mm. The laying stripper position for the output in center target is located at x = -76 mm and y =416 mm from the center coordinate on the center of dee with the energy of proton is 13 MeV at the point of beam extraction carbon foil. The changes position laying is carried out on range x = -70; y = 424 mm until x = - 118; y = 374 mm result for shifting area stripper which is still capable of deflection the electron beam. (author)

  3. Constraint based scheduling for the Goddard Space Flight Center distributed Active Archive Center's data archive and distribution system

    Science.gov (United States)

    Short, Nick, Jr.; Bedet, Jean-Jacques; Bodden, Lee; Boddy, Mark; White, Jim; Beane, John

    1994-01-01

    The Goddard Space Flight Center (GSFC) Distributed Active Archive Center (DAAC) has been operational since October 1, 1993. Its mission is to support the Earth Observing System (EOS) by providing rapid access to EOS data and analysis products, and to test Earth Observing System Data and Information System (EOSDIS) design concepts. One of the challenges is to ensure quick and easy retrieval of any data archived within the DAAC's Data Archive and Distributed System (DADS). Over the 15-year life of EOS project, an estimated several Petabytes (10(exp 15)) of data will be permanently stored. Accessing that amount of information is a formidable task that will require innovative approaches. As a precursor of the full EOS system, the GSFC DAAC with a few Terabits of storage, has implemented a prototype of a constraint-based task and resource scheduler to improve the performance of the DADS. This Honeywell Task and Resource Scheduler (HTRS), developed by Honeywell Technology Center in cooperation the Information Science and Technology Branch/935, the Code X Operations Technology Program, and the GSFC DAAC, makes better use of limited resources, prevents backlog of data, provides information about resources bottlenecks and performance characteristics. The prototype which is developed concurrently with the GSFC Version 0 (V0) DADS, models DADS activities such as ingestion and distribution with priority, precedence, resource requirements (disk and network bandwidth) and temporal constraints. HTRS supports schedule updates, insertions, and retrieval of task information via an Application Program Interface (API). The prototype has demonstrated with a few examples, the substantial advantages of using HTRS over scheduling algorithms such as a First In First Out (FIFO) queue. The kernel scheduling engine for HTRS, called Kronos, has been successfully applied to several other domains such as space shuttle mission scheduling, demand flow manufacturing, and avionics communications

  4. A systems engineering perspective on the human-centered design of health information systems.

    Science.gov (United States)

    Samaras, George M; Horst, Richard L

    2005-02-01

    The discipline of systems engineering, over the past five decades, has used a structured systematic approach to managing the "cradle to grave" development of products and processes. While elements of this approach are typically used to guide the development of information systems that instantiate a significant user interface, it appears to be rare for the entire process to be implemented. In fact, a number of authors have put forth development lifecycle models that are subsets of the classical systems engineering method, but fail to include steps such as incremental hazard analysis and post-deployment corrective and preventative actions. In that most health information systems have safety implications, we argue that the design and development of such systems would benefit by implementing this systems engineering approach in full. Particularly with regard to bringing a human-centered perspective to the formulation of system requirements and the configuration of effective user interfaces, this classical systems engineering method provides an excellent framework for incorporating human factors (ergonomics) knowledge and integrating ergonomists in the interdisciplinary development of health information systems.

  5. Gas, Liquid and Molten Targets at Cyclotron Beams: Target Systems and Related Nuclear Database

    Energy Technology Data Exchange (ETDEWEB)

    Ditrói, F.; Tárkányi, F.; Takács, S. [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary)

    2009-07-01

    In a systematic study our group worked on measurement of activation data of charged particle induced nuclear reaction possible involved in the production of radioisotopes for medical use. We have investigated the cross section and yield data of proton, deuteron helium-3 and alpha particle induced reactions on target materials for isotope productions relevant for medical applications as well as nuclear reactions on different structural material applied in construction of different target units. The acquired information are used or in the future can be used to determine the type of the construction materials optimal for building a certain target unit to be able to produce high specific activity and high quality radioactive isotope. In this work we have investigated different materials in activation point of view. Also several materials and reactions were studied for monitoring purposes. Use of thin metallic foils is a simple method to determine the parameters of the charged particle beams applied for isotope production. Using this method one can determine the energy and intensity of the bombarding beam and in certain cases the distribution or the profile of the bombarding beam. (author)

  6. Preparation of uranium electrodeposited target in aqueous system

    International Nuclear Information System (INIS)

    Chen Qiping; Li Yougen; Zhong Wenbin

    2006-03-01

    The main factors affecting uranium electrodeposition were tested and discussed. In the primary experiment about preparation of uranium isotopic target by electrodeposition, a stainless steel disk has been chosen as the target material, the electrolytic bath is comprised of UO 2 (NO 3 ) 2 and (NH 4 ) 2 C 2 O 4 , which has been adjusted to a pH of 2-3. Composition of the lost electrolytic bath was analysed by spectrophotometer. The thickness of resulting film is about 8-10 mg/cm 2 , the target having a thin, continuous, uniform layer of uranium, and its electrodeposited rate is more than 80%. (authors)

  7. Optical system for Argus 355-nm 90-mm aperture target-illumination experiments

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, B.C.; Boyd, R.; Hermes, G.; Hildum, J.S.; Linford, G.; Martin, W.E.

    1982-02-01

    The requirements of laser alignment, crystal tuning, target alignment, and laser beam diagnosis are provided by this optical system. Initial setup and preshot alignment techniques are discussed. Layout and operation are contrasted with the 532 nm target experiments.

  8. Target Probability Modulates Neuronal Activity in the Primate Saccadic System

    National Research Council Canada - National Science Library

    Basso, M

    2001-01-01

    The brain has a limited capacity to process information, so perceptual discriminations made when viewing natural visual scenes require that individual stimuli be singled out as targets for further analysis...

  9. An active target for the accelerator-based transmutation system

    Energy Technology Data Exchange (ETDEWEB)

    Grebyonkin, K.F. [Institute of Technical Physics, Chelyabinsk (Russian Federation)

    1995-10-01

    Consideration is given to the possibility of radical reduction in power requirements to the proton accelerator of the electronuclear reactor due to neutron multiplication both in the blanket and the target of an active material. The target is supposed to have the fast-neutron spectrum, and the blanket-the thermal one. The blanket and the target are separated by the thermal neutrons absorber, which is responsible for the neutron decoupling of the active target and blanket. Also made are preliminary estimations which illustrate that the realization of the idea under consideration can lead to significant reduction in power requirements to the proton beam and, hence considerably improve economic characteristics of the electronuclear reactor.

  10. Application of NASA Kennedy Space Center System Assurance Analysis methodology to nuclear power plant systems designs

    International Nuclear Information System (INIS)

    Page, D.W.

    1985-01-01

    In May of 1982, the Kennedy Space Center (KSC) entered into an agreement with the NRC to conduct a study to demonstrate the feasibility and practicality of applying the KSC System Assurance Analysis (SAA) methodology to nuclear power plant systems designs. North Carolina's Duke Power Company expressed an interest in the study and proposed the nuclear power facility at CATAWBA for the basis of the study. In joint meetings of KSC and Duke Power personnel, an agreement was made to select two CATAWBA systems, the Containment Spray System and the Residual Heat Removal System, for the analyses. Duke Power provided KSC with a full set of Final Safety Analysis Reports (FSAR) as well as schematics for the two systems. During Phase I of the study the reliability analyses of the SAA were performed. During Phase II the hazard analyses were performed. The final product of Phase II is a handbook for implementing the SAA methodology into nuclear power plant systems designs. The purpose of this paper is to describe the SAA methodology as it applies to nuclear power plant systems designs and to discuss the feasibility of its application. (orig./HP)

  11. Detecting and Georegistering Moving Ground Targets in Airborne QuickSAR via Keystoning and Multiple-Phase Center Interferometry

    Directory of Open Access Journals (Sweden)

    R. P. Perry

    2008-03-01

    Full Text Available SAR images experience significant range walk and, without some form of motion compensation, can be quite blurred. The MITRE-developed Keystone formatting simultaneously and automatically compensates for range walk due to the radial velocity component of each moving target, independent of the number of targets or the value of each target's radial velocity with respect to the ground. Target radial motion also causes moving targets in synthetic aperture radar images to appear at locations offset from their true instantaneous locations on the ground. In a multichannel radar, the interferometric phase values associated with all nonmoving points on the ground appear as a continuum of phase differences while the moving targets appear as interferometric phase discontinuities. By multiple threshold comparisons and grouping of pixels within the intensity and the phase images, we show that it is possible to reliably detect and accurately georegister moving targets within short-duration SAR (QuickSAR images.

  12. NASA Johnson Space Center Life Sciences Data System

    Science.gov (United States)

    Rahman, Hasan; Cardenas, Jeffery

    1994-01-01

    The Life Sciences Project Division (LSPD) at JSC, which manages human life sciences flight experiments for the NASA Life Sciences Division, augmented its Life Sciences Data System (LSDS) in support of the Spacelab Life Sciences-2 (SLS-2) mission, October 1993. The LSDS is a portable ground system supporting Shuttle, Spacelab, and Mir based life sciences experiments. The LSDS supports acquisition, processing, display, and storage of real-time experiment telemetry in a workstation environment. The system may acquire digital or analog data, storing the data in experiment packet format. Data packets from any acquisition source are archived and meta-parameters are derived through the application of mathematical and logical operators. Parameters may be displayed in text and/or graphical form, or output to analog devices. Experiment data packets may be retransmitted through the network interface and database applications may be developed to support virtually any data packet format. The user interface provides menu- and icon-driven program control and the LSDS system can be integrated with other workstations to perform a variety of functions. The generic capabilities, adaptability, and ease of use make the LSDS a cost-effective solution to many experiment data processing requirements. The same system is used for experiment systems functional and integration tests, flight crew training sessions and mission simulations. In addition, the system has provided the infrastructure for the development of the JSC Life Sciences Data Archive System scheduled for completion in December 1994.

  13. An Instructional Systems Approach or FAA Student Centered Training.

    Science.gov (United States)

    Federal Aviation Administration (DOT), Washington, DC.

    The Federal Aviation Administration (FAA) Academy has been using a systems approach as part of its training program since 1969. This booklet describes the general characteristics of an instructional system and explains the steps the FAA goes through in implementing the approach. These steps are: 1) recognize a need for training, 2) specify the…

  14. NOSC (Naval Ocean Systems Center) Program Manager’s Handbook.

    Science.gov (United States)

    1986-07-01

    19-3 19.1.3 Summary............................................................. 19-3 19. Gene r...Component Optimum System Performance Benefits of Human Factors Engineering HFE Methodological Tools and Design Aids Allocation of Function or Who Does What...those investigators who treat the human user as part of the system design process. Human factors engineering, or HFE , is the practice of designing

  15. Control system at the Synchrotron Radiation Research Center

    International Nuclear Information System (INIS)

    Jan, G.J.

    1991-01-01

    A modern control system was designed for SRRC to control and monitor the facilities of storage ring, beam transport line and injection system. The SRRC control system is a distributed system which is divided into two logical levels. Several process computers and workstations at upper level provide the computing power for physics simulation, data storage and graphical user interfaces. VME-based Intelligent Local Controllers (ILC) are the backbone of the lower level system which handle the real time devices access and the closed loop control. Ethernet network provides the interconnection between these two layers using IEEE 802.3 and TCP/IP protocol. The software in upper level computers includes data base server, network server, simulation programs, various application codes and X windows based graphical user interfaces. Device drivers, application programs for devices control and communication programs are the major software components at the ILC level

  16. Heat-pump-centered integrated community energy systems: system development summary

    Energy Technology Data Exchange (ETDEWEB)

    Calm, J.M.

    1980-02-01

    An introduction to district heating systems employing heat pumps to enable use of low-temperature energy sources is presented. These systems operate as thermal utilities to provide space heating and may also supply space cooling, service-water heating, and other thermal services. Otherwise-wasted heat from industrial and commercial processes, natural sources including solar and geothermal heat, and heat stored on an annual cycle from summer cooling may be effectively utilized by the systems described. These sources are abundant, and their use would conserve scarce resources and reduce adverse environmental impacts. More than one-quarter of the energy consumed in the United States is used to heat and cool buildings and to heat service water. Natural gas and oil provide approximately 83% of this energy. The systems described show potential to reduce net energy consumption for these services by 20 to 50% and to allow fuel substitution with less-scarce resources not practical in smaller, individual-building systems. Seven studies performed for the system development phase of the Department of Energy's Heat-Pump-Centered Integrated Community Energy Systems Project and to related studies are summarized. A concluding chapter tabulates data from these separately published studies.

  17. Virtual Reality Training System for a Submarine Command Center

    National Research Council Canada - National Science Library

    Maxwell, Douglas B

    2008-01-01

    The invention as disclosed is a system that uses a combined real and virtual display interaction methodology to generate the visual appearance of submarine combat control rooms and allow interaction...

  18. The meterological information system of the Karlsruhe Nuclear Research Center

    International Nuclear Information System (INIS)

    Holleuffer-Kypke, R. von; Huebschmann, W.G.; Thomas, P.; Suess, F.

    1984-01-01

    The Meteorological Information System (MIS) comprising the meteorological instruments, the computers, and the software for data processing and recording, is part of the KfK safety and control system. In 1982 is was equipped with an independent data processing system. The report explains the arrangement and the operation of the sensors and thw two process computers. For selected meteorological situations the ability of the system is demonstrated, i.e., the presentation of the vertical profiles of wind, temperature and turbulence in the lower atmospheric boundary layer as well as the calculation and graphical representation of the transport and dispersion into the KfK environment of radioactive pollutants being released by the nuclear installations of the KfK into the atmosphere. (orig.) [de

  19. The meteorological measurement system of the Karlsruhe Nuclear Research Center

    International Nuclear Information System (INIS)

    Dilger, H.

    1976-08-01

    The system mainly serves to record the parameters which are important for the diffusion of offgas plume. The system includes 47 instruments in total which are used to measure the wind velocity, the wind direction, the wind vector, the temperature, the dew point, the solar and heat radiation, the precipitations and the atmospheric pressure, most of them mounted at the 200 m high meteorological tower. (orig./HP) [de

  20. Preparation of uranium electrodeposited target in aqueous system

    Energy Technology Data Exchange (ETDEWEB)

    Qiping, Chen; Yougen, Li; Wenbin, Zhong [China Academy of Engineering Physics, Mianyang (China). Inst. of Nuclear Physics and Chemistry

    2006-03-15

    The main factors affecting uranium electrodeposition were tested and discussed. In the primary experiment about preparation of uranium isotopic target by electrodeposition, a stainless steel disk has been chosen as the target material, the electrolytic bath is comprised of UO{sub 2}(NO{sub 3}){sub 2} and (NH{sub 4}){sub 2}C{sub 2}O{sub 4}, which has been adjusted to a pH of 2-3. Composition of the lost electrolytic bath was analysed by spectrophotometer. The thickness of resulting film is about 8-10 mg/cm{sup 2}, the target having a thin, continuous, uniform layer of uranium, and its electrodeposited rate is more than 80%. (authors)

  1. A New Method for Research on the Center-Focus Problem of Differential Systems

    OpenAIRE

    Zhou, Zhengxin

    2014-01-01

    We will introduce Mironenko’s method to discuss the Poincaré center-focus problem, and compare the methods of Lyapunov and Mironenko. We apply the Mironenko method to discuss the qualitative behavior of solutions of some planar polynomial differential systems and derive the sufficient conditions for a critical point to be a center.

  2. Intention and Usage of Computer Based Information Systems in Primary Health Centers

    Science.gov (United States)

    Hosizah; Kuntoro; Basuki N., Hari

    2016-01-01

    The computer-based information system (CBIS) is adopted by almost all of in health care setting, including the primary health center in East Java Province Indonesia. Some of softwares available were SIMPUS, SIMPUSTRONIK, SIKDA Generik, e-puskesmas. Unfortunately they were most of the primary health center did not successfully implemented. This…

  3. Towards a comprehensive system of methodological considerations for cities' climate targets

    International Nuclear Information System (INIS)

    Kramers, Anna; Wangel, Josefin; Johansson, Stefan; Höjer, Mattias; Finnveden, Göran; Brandt, Nils

    2013-01-01

    Climate targets for cities abound. However, what these targets really imply is dependent on a number of decisions regarding system boundaries and methods of calculation. In order to understand and compare cities' climate targets, there is a need for a generic and comprehensive framework of key methodological considerations. This paper identifies eight key methodological considerations for the different choices that can be made when setting targets for GHG emissions in a city and arranges them in four categories: temporal scope of target, object for target setting, unit of target, and range of target. To explore how target setting is carried out in practice, the climate targets of eight European cities were analysed. The results showed that these targets cover only a limited part of what could be included. Moreover, the cities showed quite limited awareness of what is, or could be, include in the targets. This makes comparison and benchmarking between cities difficult. - Highlights: • Cities' climate targets are almost impossible to compare and benchmark. • There is a need for consistent protocols and frameworks supporting target setting. • A framework with key methodological considerations for cities' climate targets is identified. • The framework is used to explore the climate targets for eight European cities. • The difference between production- and consumption based accounting is illustrated in a new way

  4. Impact of neutron and gamma radiation on the design of NIF diagnostics and target-bay systems

    Energy Technology Data Exchange (ETDEWEB)

    Eder, D.C.; Song, P.M.; Latkowski, J.F.; Reyes, S.; O' Brien, D.W.; Lee, F.D.; Young, B.K.; Koch, J.A.; Moran, M.J.; Watts, P.W.; Kimbrough, J.R.; Ng, E.W.; Landen, O.L.; MacGowan, B.J. [Lawrence Livermore National Lab., Livermore, CA (United States)

    2006-06-15

    The design of a wide range of components in and near the target bay of the National Ignition Facility (NIF) must allow for significant radiation from neutrons and gammas. Detailed 3-dimensional Monte Carlo simulations are critical to determine neutron and gamma fluxes for all target-bay components to allow optimization of location and auxiliary shielding. Demonstration of ignition poses unique challenges because of the large range (about 3 orders of magnitude) in the yield for any given attempt at ignition. Some diagnostics will provide data independent of yield, while others will provide data for lower yields and only survive high yields with little or no damage. In addition, for a given yield there is a more than 10 orders of magnitude range in neutron and gamma fluxes depending on location in the facility. For example, sensitive components in the diagnostic mezzanines and switchyards require auxiliary shielding for high-yield shots even though they are greater than 17 meters from target chamber center (TCC) and shielded by the 2 m-thick target-bay wall. In contrast, there are components 0.2 to 2 m from TCC with little or no shielding. For these components, particular attention is being made to use low-activation material because of the extremely high neutron loading levels. Many of the components closest to target center are designed to be single use to reduce worker dose from having to refurbish highly activated components. The cryogenic target positioner is an example where activation and ease of component replacement is an important part of the design. We are developing a design process for all target-bay systems that will assure reliable operation for the full range of planned yields. (authors)

  5. Impact of neutron and gamma radiation on the design of NIF diagnostics and target-bay systems

    Science.gov (United States)

    Eder, D. C.; Song, P. M.; Latkowski, J. F.; Reyes, S.; O'Brien, D. W.; Lee, F. D.; Young, B. K.; Koch, J. A.; Moran, M. J.; Watts, P. W.; Kimbrough, J. R.; Ng, E. W.; Landen, O. L.; MacGowan, B. J.

    2006-06-01

    The design of a wide range of components in and near the target bay of the National Ignition Facility (NIF) must allow for significant radiation from neutrons and gammas. Detailed 3D Monte Carlo simulations are critical to determine neutron and gamma fluxes for all target-bay components to allow optimization of location and auxiliary shielding. Demonstration of ignition poses unique challenges because of the large range (˜ 3 orders of magnitude) in the yield for any given attempt at ignition. Some diagnostics will provide data independent of yield, while others will provide data for lower yields and only survive high yields with little or no damage. In addition, for a given yield there is a more than 10 orders of magnitude range in neutron and gamma fluxes depending on location in the facility. For example, sensitive components in the diagnostic mezzanines and switchyards require auxiliary shielding for high-yield shots even though they are greater than 17 meters from target chamber center (TCC) and shielded by the 2 m-thick target-bay wall. In contrast, there are components 0.2 to 2 m from TCC with little or no shielding. For these components, particular attention is being made to use low-activation material because of the extremely high neutron loading levels. Many of the components closest to target center are designed to be single use to reduce worker dose from having to refurbish highly activated components. The cryogenic target positioner is an example where activation and ease of component replacement is an important part of the design. We are developing a design process for all target-bay systems that will assure reliable operation for the full range of planned yields.

  6. Experimental study of hydrodynamics of target system construction with liquid metallic coolant on water models

    International Nuclear Information System (INIS)

    Beznosov, A.; Davidov, D.; Khokhlov, D.

    2001-01-01

    This paper is about experimental study of hydrodynamics of target system construction with a spherical beam window (membrane). The visualization of current and current velocity fields in energy release area was considered. The findings are used to optimize the geometrical characteristics of target system. Also report contains the information about functioning accelerator-driven system, description it principle circuit and description of basic requirements what the target design should satisfy. (authors)

  7. Intelligent adaptive systems an interaction-centered design perspective

    CERN Document Server

    Hou, Ming; Burns, Catherine

    2014-01-01

    A synthesis of recent research and developments on intelligent adaptive systems from the HF (human factors) and HCI (human-computer interaction) domains, this book provides integrated design guidance and recommendations for researchers and system developers. It addresses a recognized lack of integration between the HF and HCI research communities, which has led to inconsistencies between the research approaches adopted, and a lack of exploitation of research from one field by the other. The book establishes design guidance through the review of conceptual frameworks, analytical methodologies,

  8. Nuclear and radiation safety assurance federal target programme management system

    International Nuclear Information System (INIS)

    Kryukov, O.V.; Vasil'ev, V.A.; Nikishin, D.A.; Linge, I.I.; Obodinskij, A.N.

    2012-01-01

    The Federal Program Nuclear and Radiation Safety Assurance for 2008-2015 is presented. Specifics of Federal target program management as well as changes to program management are discussed. Data on evaluation of management effectiveness is given. Further efforts to resolve the nuclear legacy problem in Russia are also presented [ru

  9. Therapeutic targets of renin-angiotensin system in ocular disorders

    Directory of Open Access Journals (Sweden)

    Rajesh Choudhary

    2017-03-01

    Conclusions: The RAS components are present in the extrarenal tissues including ocular tissue and have an imperative role in the ocular pathophysiology. The clinical studies are needed to show the role of therapeutic modalities targeting RAS in the treatment of different ocular disorders.

  10. Development of a user-centered radiology teaching file system

    Science.gov (United States)

    dos Santos, Marcelo; Fujino, Asa

    2011-03-01

    Learning radiology requires systematic and comprehensive study of a large knowledge base of medical images. In this work is presented the development of a digital radiology teaching file system. The proposed system has been created in order to offer a set of customized services regarding to users' contexts and their informational needs. This has been done by means of an electronic infrastructure that provides easy and integrated access to all relevant patient data at the time of image interpretation, so that radiologists and researchers can examine all available data to reach well-informed conclusions, while protecting patient data privacy and security. The system is presented such as an environment which implements a distributed clinical database, including medical images, authoring tools, repository for multimedia documents, and also a peer-reviewed model which assures dataset quality. The current implementation has shown that creating clinical data repositories on networked computer environments points to be a good solution in terms of providing means to review information management practices in electronic environments and to create customized and contextbased tools for users connected to the system throughout electronic interfaces.

  11. Drug targeting systems for inflammatory disease: one for all, all for one

    NARCIS (Netherlands)

    Crielaard, B.J.; Lammers, Twan Gerardus Gertudis Maria; Schiffelers, R.M.; Storm, Gerrit

    2012-01-01

    Abstract In various systemic disorders, structural changes in the microenvironment of diseased tissues enable both passive and active targeting of therapeutic agents to these tissues. This has led to a number of targeting approaches that enhance the accumulation of drugs in the target tissues,

  12. EXPERIMENTAL TARGET INJECTION AND TRACKING SYSTEM CONSTRUCTION AND SINGLE SHOT TESTING

    International Nuclear Information System (INIS)

    PETZOLDT, R.W.; ALEXANDER, N.B.; DRAKE, T.J.; GOODIN, D.T; JONESTRACK, K; VERMILLION, B.A

    2003-01-01

    Targets must be injected into an IFE power plant at a rate of approximately 5 to 10 Hz. Targets must be tracked very accurately to allow driver beams to be aligned with defined points on the targets with accuracy ± 150 (micro)m for indirect drive and ± 20 (micro)m for direct drive. An experimental target injection and tracking system has been constructed at General Atomics. The injector system will be used as a tool for testing the survivability of various target designs and provide feedback to the target designers. Helium gas propels the targets down an 8 m gun barrel up to 400 m/s. Direct-drive targets are protected in the barrel by sabots that are spring loaded to separate into two halves after acceleration. A sabot deflector directs the sabot halves away from the target injection path. Targets will be optically tracked with laser beams and line-scan cameras. Target position and arrival time will be predicted in real time based on early target position measurements. The system installation will be described. System testing to overcome excessive projectile wear and debris in the gun barrel is presented

  13. Automatic system of production, transfer and processing of coin targets for the production of metallic radioisotopes

    Science.gov (United States)

    Pellicioli, M.; Ouadi, A.; Marchand, P.; Foehrenbacher, T.; Schuler, J.; Dick-Schuler, N.; Brasse, D.

    2017-05-01

    The work presented in this paper gathers three main technical developments aiming at 1) optimizing nuclide production by the mean of solid targets 2) automatically transferring coin targets from vault to hotcell without human intervention 3) processing target dilution and purification in hotcell automatically. This system has been installed on a ACSI TR24 cyclotron in Strasbourg France.

  14. Reliability centered maintenance pilot system implementation 241-AP-tank farm primary ventilation system final report

    International Nuclear Information System (INIS)

    MOORE TL

    2001-01-01

    When the Hanford Site Tank Farms' mission was safe storage of radioactive waste in underground storage tanks, maintenance activities focused on time-based preventive maintenance. Tank Farms' new mission to deliver waste to a vitrification plant where the waste will be processed into a form suitable for permanent storage requires a more efficient and proactive approach to maintenance. Systems must be maintained to ensure that they are operational and available to support waste feed delivery on schedule with a minimum of unplanned outages. This report describes the Reliability Centered Maintenance (RCM) pilot system that was implemented in the 241-AP Tank Farm Primary Ventilation System under PI-ORP-009 of the contract between the U.S. Department of Energy, Office of River Protection and CH2M HILL Hanford Group Inc. (CHG). The RCM analytical techniques focus on monitoring the condition of operating systems to predict equipment failures so that maintenance activities can be completed in time to prevent or mitigate unplanned equipment outages. This approach allows maintenance activities to be managed with minimal impact on plant operations. The pilot demonstration provided an opportunity for CHG staff-training in RCM principles and tailoring of the RCM approach to the Hanford Tank Farms' unique needs. This report details the implementation of RCM on a pilot system in Tank Farms

  15. Top scientific research center deploys Zambeel Aztera (TM) network storage system in high performance environment

    CERN Multimedia

    2002-01-01

    " The National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory has implemented a Zambeel Aztera storage system and software to accelerate the productivity of scientists running high performance scientific simulations and computations" (1 page).

  16. Factors Affecting Innovation Within Aeronautical Systems Center (ASC) Organizations - An inductive Study

    National Research Council Canada - National Science Library

    Feil, Eric

    2003-01-01

    .... This thesis analyzed data collected during the 2002 Chief of Staff of the Air Force Organizational Climate Survey to identify factors that affect innovation within Aeronautical Systems Center (ASC) organizations...

  17. Climate Prediction Center (CPC) NCEP-Global Forecast System (GFS) Precipitation Forecast Product

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Forecast System (GFS) forecast precipitation data at 37.5km resolution is created at the NOAA Climate Prediction Center for the purpose of near real-time...

  18. Louisville region demonstration of travel management coordination center : system pre-deployment preparation.

    Science.gov (United States)

    2013-03-01

    The purpose of the Greater Louisville Region Demonstration of Travel Management Coordination Center (TMCC): System Pre-Deploy-ment Preparation grant was to further phased implementation of the regions TMCC design by focusing on two major component...

  19. Aluminum-doped zinc oxide thin films grown on various substrates using facing target sputtering system

    Science.gov (United States)

    Kim, Hwa-Min; Lee, Chang Hyun; Shon, Sun Young; Kim, Bong Hwan

    2017-11-01

    Aluminum-doped zinc oxide (AZO) films were fabricated on various substrates, such as glass, polyethylene naphthalate (PEN), and polyethylene terephthalate (PET), at room temperature using a facing target sputtering (FTS) system with hetero ZnO and Al2O3 targets, and their electrical and optical properties were investigated. The AZO film on glass exhibited compressive stress while the films on the plastic substrates showed tensile stress. These stresses negatively affected the crystalline quality of the AZO films, and it is suggested that the poor crystalline quality of the films may be related to the neutral Al-based defect complexes formed in the films; these complexes act as neutral impurity scattering centers. AZO films with good optoelectronic properties could be formed on the glass and plastic substrates by the FTS technique using the hetero targets. The AZO films deposited on the glass, PEN, and PET substrates showed very low resistivities, of 5.0 × 10-4 Ω cm, 7.0 × 10-4 Ω cm, and 7.4 × 10-4 Ω cm, respectively. Further, the figure merit of the AZO film formed on the PEN substrate in the visible range (400-700 nm) was significantly higher than that of the AZO film on PET and similar to that of the AZO film on glass. Finally, the average transmittances of the films in the visible range (400-700 nm) were 83.16% (on glass), 76.3% (on PEN), and 78.16% (on PET).

  20. Nuclear Energy Center Site Survey, 1975. Part II. The U.S. electric power system and the potential role of nuclear energy centers

    International Nuclear Information System (INIS)

    1976-01-01

    Information related to Nuclear Energy Centers (NEC) in the U.S. is presented concerning the U.S. electric power system today; electricity demand history and forecasts; history and forecasts of the electric utility industry; regional notes; the status, history, and forecasts of the nuclear role; power plant siting problems and practices; nuclear facilities siting problems and practices; origin and evolution of the nuclear energy center concept; conceptualized description of nuclear energy centers; potential role of nuclear energy centers; assumptions, criteria, and bases; typical evolution of a nuclear energy center; and the nuclear fuel cycle

  1. Airbreathing Hypersonic Systems Focus at NASA Langley Research Center

    Science.gov (United States)

    Hunt, James L.; Rausch, Vincent L.

    1998-01-01

    This paper presents the status of the airbreathing hypersonic airplane and space-access vehicle design matrix, reflects on the synergies and issues, and indicates the thrust of the effort to resolve the design matrix and to focus/advance systems technology maturation. Priority is given to the design of the vision operational vehicles followed by flow-down requirements to flight demonstrator vehicles and their design for eventual consideration in the Future-X Program.

  2. Natick Soldier Systems Center Science and Technology Board (9th)

    Science.gov (United States)

    2012-05-29

    NSRDEC overarching CRADA’s with all five UMass campuses (in routing) • Patent License Agreement with Niche, Inc , New Bedford, MA (Ground impact...84.2 1 201 1 2014 GEAR4 UNITY REMOTE (Ben created.’deveil)j)ild~icensed) 2017 :>O?O SUM DEVICES QUANTIFIED SELF JAWBONE UP ATBIT ULTRA NIKE FUEL...Rudolph gained system development experience in multiple IT companies. In March 1994, he co-founded Paradigm Technologies, Inc ., an industry partner

  3. Development of the jet-target system of the MAGIX experiment

    Energy Technology Data Exchange (ETDEWEB)

    Stephan, Aulenbacher [Institut fuer Kernphysik, JGU, Mainz (Germany); Collaboration: Magix/MESA-Collaboration

    2016-07-01

    Since the new accelerator MESA which will be built up in Mainz in the next years operates at low Energies (100 MeV), but at high beam currents (1 mA), a thin windowless target is required. Therefore the MAGIX collaboration is developing a Jet-Target. This target blasts a Gas-Jet perpendicular to the beam through the scattering chamber of MAGIX. This talk is about the development of this Target System.

  4. Systems integration of biodefense omics data for analysis of pathogen-host interactions and identification of potential targets.

    Directory of Open Access Journals (Sweden)

    Peter B McGarvey

    2009-09-01

    Full Text Available The NIAID (National Institute for Allergy and Infectious Diseases Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including bacterial, parasitic, and viral pathogens. The program includes seven Proteomics Research Centers, generating diverse types of pathogen-host data, including mass spectrometry, microarray transcriptional profiles, protein interactions, protein structures and biological reagents. The Biodefense Resource Center (www.proteomicsresource.org has developed a bioinformatics framework, employing a protein-centric approach to integrate and support mining and analysis of the large and heterogeneous data. Underlying this approach is a data warehouse with comprehensive protein + gene identifier and name mappings and annotations extracted from over 100 molecular databases. Value-added annotations are provided for key proteins from experimental findings using controlled vocabulary. The availability of pathogen and host omics data in an integrated framework allows global analysis of the data and comparisons across different experiments and organisms, as illustrated in several case studies presented here. (1 The identification of a hypothetical protein with differential gene and protein expressions in two host systems (mouse macrophage and human HeLa cells infected by different bacterial (Bacillus anthracis and Salmonella typhimurium and viral (orthopox pathogens suggesting that this protein can be prioritized for additional analysis and functional characterization. (2 The analysis of a vaccinia-human protein interaction network supplemented with protein accumulation levels led to the identification of human Keratin, type II cytoskeletal 4 protein as a potential therapeutic target. (3 Comparison of complete genomes from pathogenic variants coupled with experimental information on complete proteomes allowed the identification and

  5. Conceptual design of the handling and storage system for spent target vessel

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Junichi; Sasaki, Shinobu; Kaminaga, Masanori; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    A conceptual design of a handling and storage system for spent target vessels has been carried out, in order to establish spent target technology for the neutron scattering facility. The spent target vessels must be treated remotely with high reliability and safety, since they are highly activated and contain the poisonous mercury. The system is composed of a target exchange trolley to exchange the target vessel, remote handling equipment such as manipulators, airtight casks for the spent target vessel, storage pits and so on. This report presents the results of conceptual design study on a basic plan, a handling procedure, main devices and their arrangement of a handling and storage system for the spent target vessels. (author)

  6. Single Center Experience with the AngioVac Aspiration System

    Energy Technology Data Exchange (ETDEWEB)

    Salsamendi, Jason, E-mail: jsalsamendi@med.miami.edu; Doshi, Mehul, E-mail: mdoshi@med.miami.edu; Bhatia, Shivank, E-mail: sbhatia1@med.miami.edu [University of Miami Miller School of Medicine/Jackson Memorial Hospital, Department of Vascular and Interventional Radiology (United States); Bordegaray, Matthew, E-mail: matthewbordegaray@gmail.com [University of Miami Miller School of Medicine/Jackson Memorial Hospital, Department Radiology (United States); Arya, Rahul, E-mail: rahul.arya@jhsmiami.org [University of Miami Miller School of Medicine/Jackson Memorial Hospital, Department of Vascular and Interventional Radiology (United States); Morton, Connor, E-mail: cmorton@med.miami.edu [University of Miami Miller School of Medicine (United States); Narayanan, Govindarajan, E-mail: gnarayanan@med.miami.edu [University of Miami Miller School of Medicine/Jackson Memorial Hospital, Department of Vascular and Interventional Radiology (United States)

    2015-08-15

    PurposeThe AngioVac catheter system is a mechanical suction device designed for removal of intravascular material using extracorporeal veno-venous bypass circuit. The purpose of this study is to present the outcomes in patients treated with the AngioVac aspiration system and to discuss its efficacy in different vascular beds.Materials and MethodsA retrospectively review was performed of seven patients treated with AngioVac between October 2013 and December 2014. In 6/7 cases, the AngioVac cannula was inserted percutaneously and the patient was placed on veno-venous bypass. In one of the cases, the cannula was inserted directly into the Fontan circuit after sternotomy and the patient was maintained on cardiopulmonary bypass. Thrombus location included iliocaval (2), SVC (1), pulmonary arteries (1), Fontan circuit and Glenn shunt with pulmonary artery extension (1), right atrium (1), and IVC with renal vein extension (1).ResultsThe majority of thrombus (50–95 %) was removed in 5/7 cases, and partial thrombus removal (<50 %) was confirmed in 2/7 cases. Mean follow-up was 205 days (range 64–403 days). All patients were alive at latest follow-up. Minor complications included three neck hematomas in two total patients. No major complications occurred.ConclusionAngioVac is a useful tool for acute thrombus removal in the large vessels. The setup and substantial cost may limit its application in straightforward cases. More studies are needed to establish the utility of AngioVac in treatment of intravascular and intracardiac material.

  7. Integrated Micro-Power System (IMPS) Development at NASA Glenn Research Center

    Science.gov (United States)

    Wilt, David; Hepp, Aloysius; Moran, Matt; Jenkins, Phillip; Scheiman, David; Raffaelle, Ryne

    2003-01-01

    Glenn Research Center (GRC) has a long history of energy related technology developments for large space related power systems, including photovoltaics, thermo-mechanical energy conversion, electrochemical energy storage. mechanical energy storage, power management and distribution and power system design. Recently, many of these technologies have begun to be adapted for small, distributed power system applications or Integrated Micro-Power Systems (IMPS). This paper will describe the IMPS component and system demonstration efforts to date.

  8. A Target Advertisement System Based on TV Viewer's Profile Reasoning

    Science.gov (United States)

    Lim, Jeongyeon; Kim, Munjo; Lee, Bumshik; Kim, Munchurl; Lee, Heekyung; Lee, Han-Kyu

    With the rapidly growing Internet, the Internet broadcasting and web casting service have been one of the well-known services. Specially, it is expected that the IPTV service will be one of the principal services in the broadband network [2]. However, the current broadcasting environment is served for the general public and requires the passive attitude to consume the TV programs. For the advanced broadcasting environments, various research of the personalized broadcasting is needed. For example, the current unidirectional advertisement provides to the TV viewers the advertisement contents, depending on the popularity of TV programs, the viewing rates, the age groups of TV viewers, and the time bands of the TV programs being broadcast. It is not an efficient way to provide the useful information to the TV viewers from customization perspective. If a TV viewer does not need particular advertisement contents, then information may be wasteful to the TV viewer. Therefore, it is expected that the target advertisement service will be one of the important services in the personalized broadcasting environments. The current research in the area of the target advertisement classifies the TV viewers into clustered groups who have similar preference. The digital TV collaborative filtering estimates the user's favourite advertisement contents by using the usage history [1, 4, 5]. In these studies, the TV viewers are required to provide their profile information such as the gender, job, and ages to the service providers via a PC or Set-Top Box (STB) which is connected to digital TV. Based on explicit information, the advertisement contents are provided to the TV viewers in a customized way with tailored advertisement contents. However, the TV viewers may dislike exposing to the service providers their private information because of the misuse of it. In this case, it is difficult to provide appropriate target advertisement service.

  9. Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease.

    Science.gov (United States)

    Ilan, Yaron

    2016-01-01

    Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs. Oral immune therapy is a method of systemic immune modulation via alteration of the gut immune system. It uses the inherit ability of the innate system of the gut to redirect the systemic innate and adaptive immune responses. Oral immune therapy is an attractive clinical approach to treat autoimmune and inflammatory disorders. It can induce immune modulation without immune suppression, has minimal toxicity and is easily administered. Targeting the systemic immune system via the gut immune system can serve as an attractive novel therapeutic method for IBD. This review summarizes the current data and discusses several examples of oral immune therapeutic methods for using the gut immune system to generate signals to reset systemic immunity as a treatment for IBD.

  10. Impact of configuration management system of computer center on support of scientific projects throughout their lifecycle

    International Nuclear Information System (INIS)

    Bogdanov, A.V.; Yuzhanin, N.V.; Zolotarev, V.I.; Ezhakova, T.R.

    2017-01-01

    In this article the problem of scientific projects support throughout their lifecycle in the computer center is considered in every aspect of support. Configuration Management system plays a connecting role in processes related to the provision and support of services of a computer center. In view of strong integration of IT infrastructure components with the use of virtualization, control of infrastructure becomes even more critical to the support of research projects, which means higher requirements for the Configuration Management system. For every aspect of research projects support, the influence of the Configuration Management system is reviewed and development of the corresponding elements of the system is described in the present paper.

  11. Impact of configuration management system of computer center on support of scientific projects throughout their lifecycle

    Science.gov (United States)

    Bogdanov, A. V.; Iuzhanin, N. V.; Zolotarev, V. I.; Ezhakova, T. R.

    2017-12-01

    In this article the problem of scientific projects support throughout their lifecycle in the computer center is considered in every aspect of support. Configuration Management system plays a connecting role in processes related to the provision and support of services of a computer center. In view of strong integration of IT infrastructure components with the use of virtualization, control of infrastructure becomes even more critical to the support of research projects, which means higher requirements for the Configuration Management system. For every aspect of research projects support, the influence of the Configuration Management system is being reviewed and development of the corresponding elements of the system is being described in the present paper.

  12. New software of the control and data acquisition system for the Nuclotron internal target station

    International Nuclear Information System (INIS)

    Isupov, A.Yu.

    2012-01-01

    The control and data acquisition system for the Internal Target Station (ITS) of the Nuclotron (LHEP, JINR) is implemented. The new software is based on the ngdp framework under the Unix-like operating system FreeBSD to allow easy network distribution of the on-line data collected from ITS, as well as the internal target remote control

  13. Real-Time Target Motion Animation for Missile Warning System Testing

    Science.gov (United States)

    2006-04-01

    T. Perkins, R. Sundberg, J. Cordell, Z. Tun , and M. Owen, Real-time Target Motion Animation for Missile Warning System Testing, Proc. SPIE Vol 6208...Z39-18 Real-time target motion animation for missile warning system testing Timothy Perkins*a, Robert Sundberga, John Cordellb, Zaw Tunb, Mark

  14. Upgrade to the Cryogenic Hydrogen Gas Target Monitoring System

    Science.gov (United States)

    Slater, Michael; Tribble, Robert

    2013-10-01

    The cryogenic hydrogen gas target at Texas A&M is a vital component for creating a secondary radioactive beam that is then used in experiments in the Momentum Achromat Recoil Spectrometer (MARS). A stable beam from the K500 superconducting cyclotron enters the gas cell and some incident particles are transmuted by a nuclear reaction into a radioactive beam, which are separated from the primary beam and used in MARS experiments. The pressure in the target chamber is monitored so that a predictable isotope production rate can be assured. A ``black box'' received the analog pressure data and sent RS232 serial data through an outdated serial connection to an outdated Visual Basic 6 (VB6) program, which plotted the chamber pressure continuously. The black box has been upgraded to an Arduino UNO microcontroller [Atmel Inc.], which can receive the pressure data and output via USB to a computer. It has been programmed to also accept temperature data for future upgrade. A new computer program, with updated capabilities, has been written in Python. The software can send email alerts, create audible alarms through the Arduino, and plot pressure and temperature. The program has been designed to better fit the needs of the users. Funded by DOE and NSF-REU Program.

  15. Spallation Neutron Source Second Target Station Integrated Systems Update

    Energy Technology Data Exchange (ETDEWEB)

    Ankner, John Francis [ORNL; An, Ke [ORNL; Blokland, Willem [ORNL; Charlton, Timothy R. [ORNL; Coates, Leighton [ORNL; Dayton, Michael J. [ORNL; Dean, Robert A. [ORNL; Dominguez-Ontiveros, Elvis E. [ORNL; Ehlers, Georg [ORNL; Gallmeier, Franz X. [ORNL; Graves, Van B. [ORNL; Heller, William T. [ORNL; Holmes, Jeffrey A. [ORNL; Huq, Ashfia [ORNL; Lumsden, Mark D. [ORNL; McHargue, William M. [ORNL; McManamy, Thomas J. [ORNL; Plum, Michael A. [ORNL; Rajic, Slobodan [ORNL; Remec, Igor [ORNL; Robertson, Lee [ORNL; Sala, Gabriele [ORNL; Stoica, Alexandru Dan [ORNL; Trotter, Steven M. [ORNL; Winn, Barry L. [ORNL; Abudureyimu, Reheman [ORNL; Rennich, Mark J. [ORNL; Herwig, Kenneth W. [ORNL

    2017-04-01

    The Spallation Neutron Source (SNS) was designed from the beginning to accommodate both an accelerator upgrade to increase the proton power and a second target station (STS). Four workshops were organized in 2013 and 2014 to identify key science areas and challenges where neutrons will play a vital role [1-4]. Participants concluded that the addition of STS to the existing ORNL neutron sources was needed to complement the strengths of High Flux Isotope Reactor (HFIR) and the SNS first target station (FTS). To address the capability gaps identified in the workshops, a study was undertaken to identify instrument concepts that could provide the required new science capabilities. The study outlined 22 instrument concepts and presented an initial science case for STS [5]. These instrument concepts formed the basis of a planning suite of instruments whose requirements determined an initial site layout and moderator selection. An STS Technical Design Report (TDR) documented the STS concept based on those choices [6]. Since issue of the TDR, the STS concept has significantly matured as described in this document.

  16. Implementing health management information systems: measuring success in Korea's health centers.

    Science.gov (United States)

    Chae, Y M; Kim, S I; Lee, B H; Choi, S H; Kim, I S

    1994-01-01

    This article analyses the effects that the introduction and adoption of a health management information system (HMIS) can have on both the productivity of health center staff as well as on user-satisfaction. The focus is upon the service provided by the Kwonsun Health Center located in Suwon City, Korea. Two surveys were conducted to measure the changes in productivity and adoption (knowledge, persuasion, decision, implementation and confirmation) of health center staff over time. In addition, a third survey was conducted to measure the effects of HMIS on the level of satisfaction perceived by the visitors, by comparing the satisfaction level between the study health center and a similar health center identified as a control. The results suggest that HMIS increased the productivity and satisfaction of the staff but did not increase their persuasion and decision levels; and, that is also succeeded in increasing the levels of visitors' satisfaction with the services provided.

  17. The peripheral GABAergic system as a target in endocrine disorders

    NARCIS (Netherlands)

    Gladkevich, A; Korf, J; Hakobyan, VP; Melkonyan, KV

    2006-01-01

    In addition to its well-recognized function as a cerebral inhibitory transmitter, less well established is the role of GABA in peripheral nervous and endocrine systems. We Summarize current evidence that GABA serves as a neurotransmitter or neuromodulator in the autonomic nervous system and as a

  18. Information Systems curriculum: the moving target phenomenon of ...

    African Journals Online (AJOL)

    This article determines the scope and nature of Information Systems training at Technikons in South Africa. Due to rapid changes in technology, knowledge regarding technology becomes obsolete rapidly. Therefore Information Systems learners should have the means and skills to keep abreast of advances in the ...

  19. Evolution of the Systems Engineering Education Development (SEED) Program at NASA Goddard Space Flight Center

    Science.gov (United States)

    Bagg, Thomas C., III; Brumfield, Mark D.; Jamison, Donald E.; Granata, Raymond L.; Casey, Carolyn A.; Heller, Stuart

    2003-01-01

    The Systems Engineering Education Development (SEED) Program at NASA Goddard Space Flight Center develops systems engineers from existing discipline engineers. The program has evolved significantly since the report to INCOSE in 2003. This paper describes the SEED Program as it is now, outlines the changes over the last year, discusses current status and results, and shows the value of human systems and leadership skills for practicing systems engineers.

  20. Rotating target wheel system for super-heavy element production at ATLAS

    CERN Document Server

    Greene, J P; Falout, J; Janssens, R V F

    2004-01-01

    A new scattering chamber housing a large diameter rotating target wheel has been designed and constructed in front of the Fragment Mass Analyzer (FMA) for the production of very heavy nuclei (Z greater than 100) using beams from the Argonne Tandem Linear Accelerator System (ATLAS). In addition to the target and drive system, the chamber is extensively instrumented in order to monitor target performance and deterioration. Capabilities also exist to install rotating entrance and exit windows for gas cooling of the target within the scattering chamber. The design and initial tests are described.

  1. Nanoparticles laden in situ gelling system for ocular drug targeting

    Directory of Open Access Journals (Sweden)

    Divya Kumar

    2013-01-01

    Full Text Available Designing an ophthalmic drug delivery system is one of the most difficult challenges for the researchers. The anatomy and physiology of eye create barriers like blinking which leads to the poor retention time and penetration of drug moiety. Some conventional ocular drug delivery systems show shortcomings such as enhanced pre-corneal elimination, high variability in efficiency, and blurred vision. To overcome these problems, several novel drug delivery systems such as liposomes, nanoparticles, hydrogels, and in situ gels have been developed. In situ-forming hydrogels are liquid upon instillation and undergo phase transition in the ocular cul-de-sac to form viscoelastic gel and this provides a response to environmental changes. In the past few years, an impressive number of novel temperature, pH, and ion-induced in situ-forming systems have been reported for sustain ophthalmic drug delivery. Each system has its own advantages and drawbacks. Thus, a combination of two drug delivery systems, i.e., nanoparticles and in situ gel, has been developed which is known as nanoparticle laden in situ gel. This review describes every aspects of this novel formulation, which present the readers an exhaustive detail and might contribute to research and development.

  2. Description of the surface water filtration and ozone treatment system at the Northeast Fishery Center

    Science.gov (United States)

    A water filtration and ozone disinfection system was installed at the U.S. Fish and Wildlife Service's Northeast Fishery Center in Lamar, Pennsylvania to treat a surface water supply that is used to culture sensitive and endangered fish. The treatment system first passes the surface water through dr...

  3. Measurements and predictions of the air distribution systems in high compute density (Internet) data centers

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jinkyun [HIMEC (Hanil Mechanical Electrical Consultants) Ltd., Seoul 150-103 (Korea); Department of Architectural Engineering, Yonsei University, Seoul 120-749 (Korea); Lim, Taesub; Kim, Byungseon Sean [Department of Architectural Engineering, Yonsei University, Seoul 120-749 (Korea)

    2009-10-15

    When equipment power density increases, a critical goal of a data center cooling system is to separate the equipment exhaust air from the equipment intake air in order to prevent the IT server from overheating. Cooling systems for data centers are primarily differentiated according to the way they distribute air. The six combinations of flooded and locally ducted air distribution make up the vast majority of all installations, except fully ducted air distribution methods. Once the air distribution system (ADS) is selected, there are other elements that must be integrated into the system design. In this research, the design parameters and IT environmental aspects of the cooling system were studied with a high heat density data center. CFD simulation analysis was carried out in order to compare the heat removal efficiencies of various air distribution systems. The IT environment of an actual operating data center is measured to validate a model for predicting the effect of different air distribution systems. A method for planning and design of the appropriate air distribution system is described. IT professionals versed in precision air distribution mechanisms, components, and configurations can work more effectively with mechanical engineers to ensure the specification and design of optimized cooling solutions. (author)

  4. Test bed control center design concept for Tank Waste Retrieval Manipulator Systems

    International Nuclear Information System (INIS)

    Sundstrom, E.; Draper, J.V.; Fausz, A.

    1995-01-01

    This paper describes the design concept for the control center for the Single Shell Tank Waste Retrieval Manipulator System test bed and the design process behind the concept. The design concept supports all phases of the test bed mission, including technology demonstration, comprehensive system testing, and comparative evaluation for further development and refinement of the TWRMS for field operations

  5. A User-Centered Cooperative Information System for Medical Imaging Diagnosis.

    Science.gov (United States)

    Gomez, Enrique J.; Quiles, Jose A.; Sanz, Marcos F.; del Pozo, Francisco

    1998-01-01

    Presents a cooperative information system for remote medical imaging diagnosis. General computer-supported cooperative work (CSCW) problems addressed are definition of a procedure for the design of user-centered cooperative systems (conceptual level); and improvement of user feedback and optimization of the communication bandwidth in highly…

  6. Theoretical Design and First Test in Laboratory of a Composite Visual Servo-Based Target Spray Robotic System

    Directory of Open Access Journals (Sweden)

    Dongjie Zhao

    2016-01-01

    Full Text Available In order to spray onto the canopy of interval planting crop, an approach of using a target spray robot with a composite vision servo system based on monocular scene vision and monocular eye-in-hand vision was proposed. Scene camera was used to roughly locate target crop, and then the image-processing methods for background segmentation, crop canopy centroid extraction, and 3D positioning were studied. Eye-in-hand camera was used to precisely determine spray position of each crop. Based on the center and area of 2D minimum-enclosing-circle (MEC of crop canopy, a method to calculate spray position and spray time was determined. In addition, locating algorithm for the MEC center in nozzle reference frame and the hand-eye calibration matrix were studied. The processing of a mechanical arm guiding nozzle to spray was divided into three stages: reset, alignment, and hovering spray, and servo method of each stage was investigated. For preliminary verification of the theoretical studies on the approach, a simplified experimental prototype containing one spray mechanical arm was built and some performance tests were carried out under controlled environment in laboratory. The results showed that the prototype could achieve the effect of “spraying while moving and accurately spraying on target.”

  7. Structural systems pharmacology: a new frontier in discovering novel drug targets.

    Science.gov (United States)

    Tan, Hepan; Ge, Xiaoxia; Xie, Lei

    2013-08-01

    The modern target-based drug discovery process, characterized by the one-drug-one-gene paradigm, has been of limited success. In contrast, phenotype-based screening produces thousands of active compounds but gives no hint as to what their molecular targets are or which ones merit further research. This presents a question: What is a suitable target for an efficient and safe drug? In this paper, we argue that target selection should take into account the proteome-wide energetic and kinetic landscape of drug-target interactions, as well as their cellular and organismal consequences. We propose a new paradigm of structural systems pharmacology to deconvolute the molecular targets of successful drugs as well as to identify druggable targets and their drug-like binders. Here we face two major challenges in structural systems pharmacology: How do we characterize and analyze the structural and energetic origins of drug-target interactions on a proteome scale? How do we correlate the dynamic molecular interactions to their in vivo activity? We will review recent advances in developing new computational tools for biophysics, bioinformatics, chemoinformatics, and systems biology related to the identification of genome-wide target profiles. We believe that the integration of these tools will realize structural systems pharmacology, enabling us to both efficiently develop effective therapeutics for complex diseases and combat drug resistance.

  8. Targeting DNA repair systems in antitubercular drug development.

    Science.gov (United States)

    Minias, Alina; Brzostek, Anna; Dziadek, Jaroslaw

    2018-01-28

    Infections with Mycobacterium tuberculosis, the causative agent of tuberculosis, are difficult to treat using currently available chemotherapeutics. Clinicians agree on the urgent need for novel drugs to treat tuberculosis. In this mini review, we summarize data that prompts the consideration of DNA repair-associated proteins as targets for the development of new antitubercular compounds. We discuss data, including gene expression data, that highlight the importance of DNA repair genes during the pathogenic cycle as well as after exposure to antimicrobials currently in use. Specifically, we report experiments on determining the essentiality of DNA repair-related genes. We report the availability of protein crystal structures and summarize discovered protein inhibitors. Further, we describe phenotypes of available gene mutants of M. tuberculosis and model organisms Mycobacterium bovis and Mycobacterium smegmatis. We summarize experiments regarding the role of DNA repair-related proteins in pathogenesis and virulence performed both in vitro and in vivo during the infection of macrophages and animals. We detail the role of DNA repair genes in acquiring mutations, which influence the rate of drug resistance acquisition. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  9. Plasma properties of RF magnetron sputtering system using Zn target

    Energy Technology Data Exchange (ETDEWEB)

    Nafarizal, N.; Andreas Albert, A. R.; Sharifah Amirah, A. S.; Salwa, O.; Riyaz Ahmad, M. A. [Microelectronic and Nanotechnology - Shamsuddin Research Centre (MiNT-SRC), Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia 86400 Parit Raja, Batu Pahat, Johor (Malaysia)

    2012-06-29

    In the present work, we investigate the fundamental properties of magnetron sputtering plasma using Zn target and its deposited Zn thin film. The magnetron sputtering plasma was produced using radio frequency (RF) power supply and Argon (Ar) as ambient gas. A Langmuir probe was used to collect the current from the plasma and from the current intensity, we calculate the electron density and electron temperature. The properties of Zn sputtering plasma at various discharge conditions were studied. At the RF power ranging from 20 to 100 W and gas pressure 5 mTorr, we found that the electron temperature was almost unchanged between 2-2.5 eV. On the other hand, the electron temperature increased drastically from 6 Multiplication-Sign 10{sup 9} to 1 Multiplication-Sign 10{sup 10}cm{sup -3} when the discharge gas pressure increased from 5 to 10 mTorr. The electron microscope images show that the grain size of Zn thin film increase when the discharge power is increased. This may be due to the enhancement of plasma density and sputtered Zn density.

  10. Tailoring Systems Engineering Processes in a Conceptual Design Environment: A Case Study at NASA Marshall Spaceflight Center's ACO

    Science.gov (United States)

    Mulqueen, John; Maples, C. Dauphne; Fabisinski, Leo, III

    2012-01-01

    This paper provides an overview of Systems Engineering as it is applied in a conceptual design space systems department at the National Aeronautics and Space Administration (NASA) Marshall Spaceflight Center (MSFC) Advanced Concepts Office (ACO). Engineering work performed in the NASA MFSC's ACO is targeted toward the Exploratory Research and Concepts Development life cycle stages, as defined in the International Council on Systems Engineering (INCOSE) System Engineering Handbook. This paper addresses three ACO Systems Engineering tools that correspond to three INCOSE Technical Processes: Stakeholder Requirements Definition, Requirements Analysis, and Integration, as well as one Project Process Risk Management. These processes are used to facilitate, streamline, and manage systems engineering processes tailored for the earliest two life cycle stages, which is the environment in which ACO engineers work. The role of systems engineers and systems engineering as performed in ACO is explored in this paper. The need for tailoring Systems Engineering processes, tools, and products in the ever-changing engineering services ACO provides to its customers is addressed.

  11. Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition

    NARCIS (Netherlands)

    Westra, E.R.; Semenova, E.; Datsenko, K.A.; Jackson, R.N.; Wiedenheft, B.; Severinov, K.; Brouns, S.J.J.

    2013-01-01

    Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts

  12. Directions for reactor target design based on the US heavy ion fusion systems assessment

    International Nuclear Information System (INIS)

    Wilson, D.C.; Dudziak, D.; Magelssen, G.; Zuckerman, D.; Dreimeyer, D.

    1986-01-01

    We studied areas of major uncertainty in target design using the cost of electricity as our figure of merit. Net electric power from the plant was fixed at 1000 MW to eliminate large effects due to economies of scale. The system is relatively insensitive to target gain. Factors of three changes in gain cause only 8 to 12% changes in electricity cost. An increase in the peak power needed to drive targets poses only a small cost risk, but requires many more beamlets be transported to the target. A shortening of the required ion range causes both cost and beamlet difficulties. A factor of 4 decrease in the required range at a fixed driver energy increases electricity cost by 44% and raises the number of beamlets to 240. Finally, the heavy ion fusion system can accommodate large increases in target costs. To address the major uncertainties, target design should concentrate on the understanding requirements for ion range and peak driver power

  13. The immune system as a target for antibiotics

    NARCIS (Netherlands)

    Grondel, J.L.

    1986-01-01

    Studies on antibiotics, oxytetracycline (OxyTC) in particular, are presented in this thesis with respect to the influence of these drugs on the immune system of carp and chickens. Special attention was paid to the pharmacokinetic behaviour of

  14. Targeted nanodrug delivery systems for the treatment of Tuberculosis

    CSIR Research Space (South Africa)

    Lemmer, Yolandy

    2010-06-01

    Full Text Available patient treatment compliance and drug resistance pose a great challenge to TB treatment programs worldwide. To improve the current inadequate therapeutic management of TB, a polymeric anti-TB nanodrug delivery system for anti-TB drugs was developed...

  15. A proton microbeam deflection system to scan target surfaces

    International Nuclear Information System (INIS)

    Heck, D.

    1978-12-01

    A system to deflect the proton beam within the Karlsruhe microbeam setup is described. The deflection is achieved whithin a transverse electrical field generated between parallel electrodes. Their tension is controlled by a pattern generator, thus enabling areal and line scans with a variable number of scan points at variable scan speed. The application is demonstrated at two different examples. (orig.) [de

  16. Targeting the humoral immune system of patients with rheumatoid arthritis

    NARCIS (Netherlands)

    Teng, Yoe Kie Onno

    2008-01-01

    The aim of this thesis was to unravel the role of the humoral immune system in rheumatoid arthritis patients by employing new immunosuppressive strategies, i.e. specific B-cell depletion with Rituximab and non-specific lymfoablative treatment with high dose chemotherapy and hematopoeietic stem cell

  17. Evaluating trauma center structural performance: The experience of a Canadian provincial trauma system

    Directory of Open Access Journals (Sweden)

    Lynne Moore

    2013-01-01

    Full Text Available Background: Indicators of structure, process, and outcome are required to evaluate the performance of trauma centers to improve the quality and efficiency of care. While periodic external accreditation visits are part of most trauma systems, a quantitative indicator of structural performance has yet to be proposed. The objective of this study was to develop and validate a trauma center structural performance indicator using accreditation report data. Materials and Methods: Analyses were based on accreditation reports completed during on-site visits in the Quebec trauma system (1994-2005. Qualitative report data was retrospectively transposed onto an evaluation grid and the weighted average of grid items was used to quantify performance. The indicator of structural performance was evaluated in terms of test-retest reliability (kappa statistic, discrimination between centers (coefficient of variation, content validity (correlation with accreditation decision, designation level, and patient volume and forecasting (correlation between visits performed in 1994-1999 and 1998-2005. Results: Kappa statistics were >0.8 for 66 of the 73 (90% grid items. Mean structural performance score over 59 trauma centers was 47.4 (95% CI: 43.6-51.1. Two centers were flagged as outliers and the coefficient of variation was 31.2% (95% CI: 25.5% to 37.6%, showing good discrimination. Correlation coefficients of associations with accreditation decision, designation level, and volume were all statistically significant (r = 0.61, -0.40, and 0.24, respectively. No correlation was observed over time (r = 0.03. Conclusion: This study demonstrates the feasibility of quantifying trauma center structural performance using accreditation reports. The proposed performance indicator shows good test-retest reliability, between-center discrimination, and construct validity. The observed variability in structural performance across centers and over-time underlines the importance of

  18. VIRTUAL COGNITIVE CENTERS AS INTELLIGENT SYSTEMS FOR MANAGEMENT INFORMATION SUPPORT OF REGIONAL SECURITY

    Directory of Open Access Journals (Sweden)

    A. V. Masloboev

    2014-03-01

    Full Text Available The paper deals with engineering problems and application perspectives of virtual cognitive centers as intelligent systems for information support of interagency activities in the field of complex security management of regional development. A research prototype of virtual cognitive center for regional security management in crisis situations, implemented as hybrid cloud service based on IaaS architectural framework with the usage of multi-agent and web-service technologies has been developed. Virtual cognitive center is a training simulator software system and is intended for solving on the basis of distributed simulation such problems as: strategic planning and forecasting of risk-sustainable development of regional socioeconomic systems, agents of management interaction specification synthesis for regional components security in different crisis situations within the planning stage of joint anti-crisis actions.

  19. A Customer Relationship Management System to Target Customers at Cisco

    OpenAIRE

    Rahul Bhaskar

    2004-01-01

    This case describes the implementation of an Internet empowered Customer Relationship Management (CRM) at Cisco Systems Inc. After describing the organizational background of Cisco, the case takes the student into the issues that the executives faced after the market crash in 2001. John Chambers, Cisco CEO, and his team decided to strengthen Cisco’s relationship with the customers so that the company could emerge stronger when the markets recovered. Questions are raised as to the implementa...

  20. Transportable Payload Operations Control Center reusable software: Building blocks for quality ground data systems

    Science.gov (United States)

    Mahmot, Ron; Koslosky, John T.; Beach, Edward; Schwarz, Barbara

    1994-01-01

    The Mission Operations Division (MOD) at Goddard Space Flight Center builds Mission Operations Centers which are used by Flight Operations Teams to monitor and control satellites. Reducing system life cycle costs through software reuse has always been a priority of the MOD. The MOD's Transportable Payload Operations Control Center development team established an extensive library of 14 subsystems with over 100,000 delivered source instructions of reusable, generic software components. Nine TPOCC-based control centers to date support 11 satellites and achieved an average software reuse level of more than 75 percent. This paper shares experiences of how the TPOCC building blocks were developed and how building block developer's, mission development teams, and users are all part of the process.

  1. Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology.

    Science.gov (United States)

    Ianni, Alessandro; Yuan, Xuejun; Bober, Eva; Braun, Thomas

    2018-06-01

    Cardiovascular diseases represent a major cause of death and morbidity. Cardiac and vascular pathologies develop predominantly in the aged population in part due to lifelong exposure to numerous risk factors but are also found in children and during adolescence. In comparison to adults, much has to be learned about the molecular pathways driving cardiovascular diseases in the pediatric population. Sirtuins are highly conserved enzymes that play pivotal roles in ensuring cardiac homeostasis under physiological and stress conditions. In this review, we discuss novel findings about the biological functions of these molecules in the cardiovascular system and their possible involvement in pediatric cardiovascular diseases.

  2. Task analysis and structure scheme for center manager station in large container inspection system

    International Nuclear Information System (INIS)

    Li Zheng; Gao Wenhuan; Wang Jingjin; Kang Kejun; Chen Zhiqiang

    1997-01-01

    LCIS works as follows: the accelerator generates beam pulses which are formed into fan shape; the scanning system drags a lorry with a container passing through the beam in constant speed; the detector array detects the beam penetrating the lorry; the projection data acquisition system reads the projections and completes an inspection image of the lorry. All these works are controlled and synchronized by the center manage station. The author will describe the process of the projection data acquisition in scanning mode and the methods of real-time projection data processing. the task analysis and the structure scheme of center manager station is presented

  3. Approach to training the trainer at the Bell System Training Center

    International Nuclear Information System (INIS)

    Housley, E.A.; Stevenson, J.L.

    1981-01-01

    The major activity of the Bell System Training Center is to develop and deliver technical training. Experts in various technical areas are selected as course developers or instructors, usually on rotational assignments. Through a series of workshops, described in this paper, combined with coaching, use of job aids and working with more experienced peers, they become competent developers or instructors. There may be similarities between the mission of the Bell System Training Center and other contexts where criticality of job performance and technical subject matter are training characteristics

  4. Professional soldier assessment of a rifle-mounted target hand-off system

    NARCIS (Netherlands)

    Levesque, J.; Banko, K.; Binsch, O.

    2015-01-01

    The miniaturization of digital image acquisition and processing hardware, positional sensors, and batteries has enabled the creation of assisted targeting systems light enough to be integrated onto small firearms to increase the probability of soldiers detecting and hitting targets. As well, the

  5. The endocannabinoid system: a new pharmacological target for obesity treatment?

    Science.gov (United States)

    Hu, Jia; Zhu, Chao; Huang, Mao

    2009-06-01

    Being a great threaten for human health, obesity has become a pandemic chronic disease. There have been several therapeutic treatments for this social health issue, including diet and exercise therapy, medication and surgery, among which the diet is still the most common way. However, none of these therapeutic measures available is ideal, making it necessary to find an effective medical treatment. The endocannabinoid system, which is well known for its contributions in certain mental processes such as relaxation, amelioration of pain and anxiety, and sedation initiation, has been recently reported to play an essential role in regulating appetite and metabolism to maintain energy balance, leading to the belief that endocannabinoid system is closely related to obesity. This new discovery deepens our understanding of obesity, and provides us with a new direction for clinical obesity treatment. Rimonabant is an antagonist for CB1, and has entered the market in some countries. However, although effective as an anti-obesity drug, rimonabant also causes obviously adverse side-effects, thus is being doubted and denied for medical usage.

  6. Influence of socioeconomic status on trauma center performance evaluations in a Canadian trauma system.

    Science.gov (United States)

    Moore, Lynne; Turgeon, Alexis F; Sirois, Marie-Josée; Murat, Valérie; Lavoie, André

    2011-09-01

    Trauma center performance evaluations generally include adjustment for injury severity, age, and comorbidity. However, disparities across trauma centers may be due to other differences in source populations that are not accounted for, such as socioeconomic status (SES). We aimed to evaluate whether SES influences trauma center performance evaluations in an inclusive trauma system with universal access to health care. The study was based on data collected between 1999 and 2006 in a Canadian trauma system. Patient SES was quantified using an ecologic index of social and material deprivation. Performance evaluations were based on mortality adjusted using the Trauma Risk Adjustment Model. Agreement between performance results with and without additional adjustment for SES was evaluated with correlation coefficients. The study sample comprised a total of 71,784 patients from 48 trauma centers, including 3,828 deaths within 30 days (4.5%) and 5,549 deaths within 6 months (7.7%). The proportion of patients in the highest quintile of social and material deprivation varied from 3% to 43% and from 11% to 90% across hospitals, respectively. The correlation between performance results with or without adjustment for SES was almost perfect (r = 0.997; 95% CI 0.995-0.998) and the same hospital outliers were identified. We observed an important variation in SES across trauma centers but no change in risk-adjusted mortality estimates when SES was added to adjustment models. Results suggest that after adjustment for injury severity, age, comorbidity, and transfer status, disparities in SES across trauma center source populations do not influence trauma center performance evaluations in a system offering universal health coverage. Copyright © 2011 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  7. Conceptual design report for the University of Rochester cryogenic target delivery system

    Energy Technology Data Exchange (ETDEWEB)

    Fagaly, R.L.; Alexander, N.B.; Bourque, R.F.; Dahms, C.F.; Lindgren, J.R.; Miller, W.J. (General Atomics, San Diego, CA (United States)); Bittner, D.N.; Hendricks, C.D. (W.J. Schafer Associates, Livermore, CA (United States))

    1993-05-01

    The upgrade of the Omega laser at the University of Rochester's Laboratory for Laser Energetics (UR/LLE) will result in a need for large targets filled with D[sub 2] or Dt and maintained at cryogenic temperatures. This mandates a cryogenic target delivery system capable of filling, layering, characterizing and delivering cryogenic targets to the Omega Upgrade target chamber. The program goal is to design, construct, and test the entire target delivery system by June 1996. When completed (including an operational demonstration), the system will be shipped to Rochester for reassembly and commissioning in time for the Omega Upgrade cryogenic campaign, scheduled to start in 1998. General Atomics has been assigned the task of developing the conceptual design for the cryogenic target delivery system. Design and fabrication activities will be closely coordinated with the University of Rochester, Lawrence Livermore National laboratory (LLNL) and Los Alamos National Laboratory (LANL), drawing upon their knowledge base in fuel layering and cryogenic characterization. The development of a target delivery system for Omega could also benefit experiments at Lawrence Livermore National Laboratory and the other ICF Laboratories in that the same technologies could be applied to NOVA, the National Ignition Facility or the future Laboratory Microfusion Facility.

  8. Conceptual design report for the University of Rochester cryogenic target delivery system

    Energy Technology Data Exchange (ETDEWEB)

    Fagaly, R.L.; Alexander, N.B.; Bourque, R.F.; Dahms, C.F.; Lindgren, J.R.; Miller, W.J. [General Atomics, San Diego, CA (United States); Bittner, D.N.; Hendricks, C.D. [W.J. Schafer Associates, Livermore, CA (US)

    1993-05-01

    The upgrade of the Omega laser at the University of Rochester`s Laboratory for Laser Energetics (UR/LLE) will result in a need for large targets filled with D{sub 2} or Dt and maintained at cryogenic temperatures. This mandates a cryogenic target delivery system capable of filling, layering, characterizing and delivering cryogenic targets to the Omega Upgrade target chamber. The program goal is to design, construct, and test the entire target delivery system by June 1996. When completed (including an operational demonstration), the system will be shipped to Rochester for reassembly and commissioning in time for the Omega Upgrade cryogenic campaign, scheduled to start in 1998. General Atomics has been assigned the task of developing the conceptual design for the cryogenic target delivery system. Design and fabrication activities will be closely coordinated with the University of Rochester, Lawrence Livermore National laboratory (LLNL) and Los Alamos National Laboratory (LANL), drawing upon their knowledge base in fuel layering and cryogenic characterization. The development of a target delivery system for Omega could also benefit experiments at Lawrence Livermore National Laboratory and the other ICF Laboratories in that the same technologies could be applied to NOVA, the National Ignition Facility or the future Laboratory Microfusion Facility.

  9. Conceptual design report for the University of Rochester cryogenic target delivery system

    International Nuclear Information System (INIS)

    Fagaly, R.L.; Alexander, N.B.; Bourque, R.F.; Dahms, C.F.; Lindgren, J.R.; Miller, W.J.; Bittner, D.N.; Hendricks, C.D.

    1993-05-01

    The upgrade of the Omega laser at the University of Rochester's Laboratory for Laser Energetics (UR/LLE) will result in a need for large targets filled with D 2 or Dt and maintained at cryogenic temperatures. This mandates a cryogenic target delivery system capable of filling, layering, characterizing and delivering cryogenic targets to the Omega Upgrade target chamber. The program goal is to design, construct, and test the entire target delivery system by June 1996. When completed (including an operational demonstration), the system will be shipped to Rochester for reassembly and commissioning in time for the Omega Upgrade cryogenic campaign, scheduled to start in 1998. General Atomics has been assigned the task of developing the conceptual design for the cryogenic target delivery system. Design and fabrication activities will be closely coordinated with the University of Rochester, Lawrence Livermore National laboratory (LLNL) and Los Alamos National Laboratory (LANL), drawing upon their knowledge base in fuel layering and cryogenic characterization. The development of a target delivery system for Omega could also benefit experiments at Lawrence Livermore National Laboratory and the other ICF Laboratories in that the same technologies could be applied to NOVA, the National Ignition Facility or the future Laboratory Microfusion Facility

  10. Coping with Atmospheric Turbulence in the Selection of Laser Hardening Technology for FCS Targeting Systems

    National Research Council Canada - National Science Library

    Pritchett, Timothy M

    2004-01-01

    ... by frequency-agile battlefield lasers at both long and short range. Evidently, the selection of sensor protection technologies for incorporation into the final targeting system will be based on their optical limiting performance under field conditions...

  11. Performance of target detection algorithm in compressive sensing miniature ultraspectral imaging compressed sensing system

    Science.gov (United States)

    Gedalin, Daniel; Oiknine, Yaniv; August, Isaac; Blumberg, Dan G.; Rotman, Stanley R.; Stern, Adrian

    2017-04-01

    Compressive sensing theory was proposed to deal with the high quantity of measurements demanded by traditional hyperspectral systems. Recently, a compressive spectral imaging technique dubbed compressive sensing miniature ultraspectral imaging (CS-MUSI) was presented. This system uses a voltage controlled liquid crystal device to create multiplexed hyperspectral cubes. We evaluate the utility of the data captured using the CS-MUSI system for the task of target detection. Specifically, we compare the performance of the matched filter target detection algorithm in traditional hyperspectral systems and in CS-MUSI multiplexed hyperspectral cubes. We found that the target detection algorithm performs similarly in both cases, despite the fact that the CS-MUSI data is up to an order of magnitude less than that in conventional hyperspectral cubes. Moreover, the target detection is approximately an order of magnitude faster in CS-MUSI data.

  12. Development of Cursor-on-Target Control for Semi-Autonomous Unmanned Aircraft Systems

    National Research Council Canada - National Science Library

    Crouse, Joshua D

    2007-01-01

    .... The goal of this research is to develop a preliminary Cursor-on-Target control system to enable the operator to guide the unmanned aircraft with minimal workload during high task phases of flight...

  13. Double-shell target designs for the Los Alamos Scientific Laboratory eight-beam laser system

    International Nuclear Information System (INIS)

    Kindel, J.M.; Stroscio, M.A.

    1978-03-01

    We investigate two double-pusher laser fusion targets, one that incorporates an outer exploding pusher shell and another that uses velocity multiplication. Specific designs are presented for the Los Alamos Scientific Laboratory Eight-Beam Laser System

  14. Mechanical design and development of a high power target system for the SLC Positron Source

    International Nuclear Information System (INIS)

    Reuter, E.; Mansour, D.; Porter, T.; Sax, W.; Szumillo, A.

    1991-12-01

    In order to bring the SLC Positron Source luminosity up to design specifications, the previous (stationary) positron target had to be replaced with a version which could reliably dissipate the higher power levels and cyclic pulsed thermal stresses of the high intensity 33GeV electron beam. In addition to this basic requirement, the new target system had to meet SLAC's specifications for Ultra High Vacuum, be remotely controllable, ''radiation hard,'' and designed in such a way that it could be removed and replaced quickly and easily with minimum personnel exposure to radiation. It was also desirable to integrate the target and collection components into a compact, easily manufacturable, and easily maintainable module. This paper briefly summarize the mechanical design and development of the new modular target system, its associated controls and software, alignment, and the quick removal system. Operational experience gained with the new system over the first running cycle is also summarized

  15. Cryogenic-laser-fusion target implosion studies performed with the OMEGA uv-laser system

    International Nuclear Information System (INIS)

    Marshall, F.J.; Letzring, S.A.; Verdon, C.P.; Skupsky, S.; Keck, R.L.; Knauer, J.P.; Kremens, R.L.; Bradley, D.K.; Kessler, T.; Delettrez, J.; and others.

    1989-01-01

    A series of direct-drive laser-fusion implosion experiments was performed on cryogenically cooled, DT-filled glass microballoons with the OMEGA 24-beam uv (351-nm) laser system. The targets consisted of glass microballoons having radii of 100 to 150 μm, wall thicknesses of 3 to 7 μm, filled with DT gas at pressures of 75 to 100 atm. The targets were cooled to below the freezing point of DT, in situ, by a cryogenic target system. The targets were irradiated by approximately 1 to 1.2 kJ of uv light in 650-ps Gaussian pulses. The on-target irradiation uniformity was enhanced for these experiments by the use of distributed phase plates, which brought the estimated irradiation nonuniformities to ∼12% (σ rms ). Target performance was diagnosed by an array of x-ray, plasma, and nuclear instruments. The measured target performance showed ∼70% absorption, thermonuclear yields of 10 6 to 10 8 neutrons, and final fuel areal densities of 20 to 40 mg/cm 2 for the optimum targets examined in these experiments. Fuel densities at the time of thermonuclear neutron production, inferred from direct measurements of the fuel areal density, were in the range of 20 to 50 g/cm 3 (100 to 200 times the density of liquid DT) for the optimum targets

  16. Experimental study of liquid-metal target designs of accelerating-controlled systems

    International Nuclear Information System (INIS)

    Iarmonov, Mikhail; Makhov, Kirill; Novozhilova, Olga; Meluzov, A.G.; Beznosov, A.V.

    2011-01-01

    Models of a liquid-metal target of an accelerator-controlled system have been experimentally studied at the Nizhny Novgorod State Technical University to develop an optimal design of the flow part of the target. The main explored variants of liquid-metal targets are: Design with a diaphragm (firm-and-impervious plug) mounted on the pipe tap of particle transport from the accelerator cavity to the working cavity of the liquid-metal target. Design without a diaphragm on the pipe tab of particle transport from the accelerator. The study was carried out in a high-temperature liquid-metal test bench under the conditions close to full-scale ones: the temperature of the eutectic lead-bismuth alloy was 260degC - 400degC, the coolant mass flow was 5-80 t/h, and the rarefaction in the gas cavity was 10 5 Pa, the coefficient of geometric similarity equal to 1. The experimental studies of hydrodynamic characteristics of flow parts in the designs of targets under full-scale conditions indicated high efficiency of a target in triggering, operating, and deactivating modes. Research and technology instructions for designs of the flow part of the liquid-metal target, the target design as a whole, and the target circuit of accelerator-controlled systems were formulated as a result of the studies. (author)

  17. Transmutation of 126Sn in spallation targets of accelerator-driven systems

    International Nuclear Information System (INIS)

    Han, Chi Young; Saito, Masaki; Sagara, Hiroshi

    2009-01-01

    The practical feasibility of 126 Sn transmutation in spallation targets of accelerator-driven systems was evaluated from the viewpoints of accumulation of radioactive spallation products and neutron production as well as transmutation amount of 126 Sn. A cylindrical liquid 126 Sn target whose length depends on proton beam energy was described, based on a Pb-Bi target design of accelerator-driven system being developed in JAEA. A proton beam of 1.5 GeV-20 mA was estimated to give the transmutation rate of 126 Sn 6.4 kg/yr, which corresponds to the amount of 126 Sn annually discharged in 27 LWRs of 1 GWt and 33 GWd/THM. The equilibrium radioactivity of spallation products would reach 9% of that of 126 Sn transmuted in the spallation target, and the equilibrium toxicity would be just 3%. Some parametric analyses showed that the effective half-life of 126 Sn could be reduced through a proper reduction of the target size. The 126 Sn target was calculated to produce 40 neutrons per proton of 1.5 GeV and give a neutron spectrum very similar to that of the reference Pb-Bi target. As a result, the transmutation of 126 Sn in the spallation target has a high feasibility in terms of better transmutation performance and comparable target performance. (author)

  18. The Internet and Computer User Profile: a questionnaire for determining intervention targets in occupational therapy at mental health vocational centers.

    Science.gov (United States)

    Regev, Sivan; Hadas-Lidor, Noami; Rosenberg, Limor

    2016-08-01

    In this study, the assessment tool "Internet and Computer User Profile" questionnaire (ICUP) is presented and validated. It was developed in order to gather information for setting intervention goals to meet current demands. Sixty-eight subjects aged 23-68 participated in the study. The study group (n = 28) was sampled from two vocational centers. The control group consisted of 40 participants from the general population that were sampled by convenience sampling based on the demographics of the study group. Subjects from both groups answered the ICUP questionnaire. Subjects of the study group answered the General Self- Efficacy (GSE) questionnaire and performed the Assessment of Computer Task Performance (ACTP) test in order to examine the convergent validity of the ICUP. Twenty subjects from both groups retook the ICUP questionnaire in order to obtain test-retest results. Differences between groups were tested using multiple analysis of variance (MANOVA) tests. Pearson and Spearman's tests were used for calculating correlations. Cronbach's alpha coefficient and k equivalent were used to assess internal consistency. The results indicate that the questionnaire is valid and reliable. They emphasize that the layout of the ICUP items facilitates in making a comprehensive examination of the client's perception regarding his participation in computer and internet activities. Implications for Rehabiliation The assessment tool "Internet and Computer User Profile" (ICUP) questionnaire is a novel assessment tool that evaluates operative use and individual perception of computer activities. The questionnaire is valid and reliable for use with participants of vocational centers dealing with mental illness. It is essential to facilitate access to computers for people with mental illnesses, seeing that they express similar interest in computers and internet as people from the general population of the same age. Early intervention will be particularly effective for young

  19. Penalty dynamic programming algorithm for dim targets detection in sensor systems.

    Science.gov (United States)

    Huang, Dayu; Xue, Anke; Guo, Yunfei

    2012-01-01

    In order to detect and track multiple maneuvering dim targets in sensor systems, an improved dynamic programming track-before-detect algorithm (DP-TBD) called penalty DP-TBD (PDP-TBD) is proposed. The performances of tracking techniques are used as a feedback to the detection part. The feedback is constructed by a penalty term in the merit function, and the penalty term is a function of the possible target state estimation, which can be obtained by the tracking methods. With this feedback, the algorithm combines traditional tracking techniques with DP-TBD and it can be applied to simultaneously detect and track maneuvering dim targets. Meanwhile, a reasonable constraint that a sensor measurement can originate from one target or clutter is proposed to minimize track separation. Thus, the algorithm can be used in the multi-target situation with unknown target numbers. The efficiency and advantages of PDP-TBD compared with two existing methods are demonstrated by several simulations.

  20. Design of a Mission Data Storage and Retrieval System for NASA Dryden Flight Research Center

    Science.gov (United States)

    Lux, Jessica; Downing, Bob; Sheldon, Jack

    2007-01-01

    The Western Aeronautical Test Range (WATR) at the NASA Dryden Flight Research Center (DFRC) employs the WATR Integrated Next Generation System (WINGS) for the processing and display of aeronautical flight data. This report discusses the post-mission segment of the WINGS architecture. A team designed and implemented a system for the near- and long-term storage and distribution of mission data for flight projects at DFRC, providing the user with intelligent access to data. Discussed are the legacy system, an industry survey, system operational concept, high-level system features, and initial design efforts.

  1. Integrated Solution of a Back Office System for Serious Games Targeted at Physiotherapy

    Directory of Open Access Journals (Sweden)

    Tiago Martins

    2016-01-01

    Full Text Available Serious games targeted at physiotherapy can be a solution to help the physical therapy professionals. However, the entire game management, in its various aspects, is under the professional’s responsibility. One way to reduce the professional management work will be to integrate a Back Office system in the game. Following this trend, the purpose of this paper is to present a modular Back Office system for centralized management of one or more games targeted at physical therapy.

  2. Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.

    Science.gov (United States)

    Zimmermann, Stefanie; Oufir, Mouhssin; Leroux, Alejandro; Krauth-Siegel, R Luise; Becker, Katja; Kaiser, Marcel; Brun, Reto; Hamburger, Matthias; Adams, Michael

    2013-11-15

    In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs α,β-unsaturated methylene moieties act as Michael acceptors for glutathione (GSH) and trypanothione (T(SH)2), the main low molecular mass thiols essential for unique redox metabolism of these parasites. The analysis of this putative mechanism and the effects of CYN on enzymes of the T(SH)2 redox metabolism including trypanothione reductase, trypanothione synthetase, glutathione-S-transferase, and ornithine decarboxylase are shown. A two step extraction protocol with subsequent UPLC-MS/MS analysis was established to quantify intra-cellular CYN, T(SH)2, GSH, as well as GS-CYN and T(S-CYN)2 adducts in intact T. b. rhodesiense cells. Within minutes of exposure to CYN, the cellular GSH and T(SH)2 pools were entirely depleted, and the parasites entered an apoptotic stage and died. CYN also showed inhibition of the ornithine decarboxylase similar to the positive control eflornithine. Significant interactions with the other enzymes involved in the T(SH)2 redox metabolism were not observed. Alongside many other biological activities sesquiterpene lactones including CYN have shown antitrypanosomal effects, which have been postulated to be linked to formation of Michael adducts with cellular nucleophiles. Here the interaction of CYN with biological thiols in a cellular system in general, and with trypanosomal T(SH)2 redox metabolism in particular, thus offering a molecular explanation for the antitrypanosomal activity is demonstrated. At the same time, the study provides a novel extraction and analysis protocol for components of the trypanosomal thiol metabolism. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. An analytical approach of thermodynamic behavior in a gas target system on a medical cyclotron.

    Science.gov (United States)

    Jahangiri, Pouyan; Zacchia, Nicholas A; Buckley, Ken; Bénard, François; Schaffer, Paul; Martinez, D Mark; Hoehr, Cornelia

    2016-01-01

    An analytical model has been developed to study the thermo-mechanical behavior of gas targets used to produce medical isotopes, assuming that the system reaches steady-state. It is based on an integral analysis of the mass and energy balance of the gas-target system, the ideal gas law, and the deformation of the foil. The heat transfer coefficients for different target bodies and gases have been calculated. Excellent agreement is observed between experiments performed at TRIUMF's 13 MeV cyclotron and the model. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Elucidating antimalarial drug targets/mode-of-action by application of system biology technologies

    CSIR Research Space (South Africa)

    Becker, J

    2008-11-01

    Full Text Available targets/mode-of-action by application of systems biology technologies J BECKER, L MTWISHA, B CRAMPTON AND D MANCAMA CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa Email: JBecker@csir.co.za – www.csir.co.za INTRODUCTION Malaria is one... The objective of this study was to use systems biology tools to unravel the drug target/mode-of-action (MoA) of an antimalarial drug (cyclohexylamine) with a known drug target/MoA, by analysing differential expression profiles of drug treated vs untreated...

  5. Innovation in user-centered skills and performance improvement for sustainable complex service systems.

    Science.gov (United States)

    Karwowski, Waldemar; Ahram, Tareq Z

    2012-01-01

    In order to leverage individual and organizational learning and to remain competitive in current turbulent markets it is important for employees, managers, planners and leaders to perform at high levels over time. Employee competence and skills are extremely important matters in view of the general shortage of talent and the mobility of employees with talent. Two factors emerged to have the greatest impact on the competitiveness of complex service systems: improving managerial and employee's knowledge attainment for skills, and improving the training and development of the workforce. This paper introduces the knowledge-based user-centered service design approach for sustainable skill and performance improvement in education, design and modeling of the next generation of complex service systems. The rest of the paper cover topics in human factors and sustainable business process modeling for the service industry, and illustrates the user-centered service system development cycle with the integration of systems engineering concepts in service systems. A roadmap for designing service systems of the future is discussed. The framework introduced in this paper is based on key user-centered design principles and systems engineering applications to support service competitiveness.

  6. VR-Smart Home, prototyping of a user centered design system

    NARCIS (Netherlands)

    Heidari Jozam, M.; Allameh, E.; Vries, de B.; Timmermans, H.J.P.; Masoud, M.; Andreev, S.; Balandin, S.; Yevgeni, Koucheryavy

    2012-01-01

    In this paper, we propose a prototype of a user centered design system for Smart Homes which lets users: (1) configure different interactive tasks, and (2) express activity specifications and preferences during the design process. The main objective of this paper is how to create and to implement VR

  7. CENTER CONDITIONS AND CYCLICITY FOR A FAMILY OF CUBIC SYSTEMS: COMPUTER ALGEBRA APPROACH.

    Science.gov (United States)

    Ferčec, Brigita; Mahdi, Adam

    2013-01-01

    Using methods of computational algebra we obtain an upper bound for the cyclicity of a family of cubic systems. We overcame the problem of nonradicality of the associated Bautin ideal by moving from the ring of polynomials to a coordinate ring. Finally, we determine the number of limit cycles bifurcating from each component of the center variety.

  8. Lightcurve Analysis of Hilda Asteroids at the Center for Solar System Studies: 2017 October-December

    Science.gov (United States)

    Warner, Brian D.; Stephens, Robert D.; Coley, Daniel R.

    2018-04-01

    Lightcurves for 12 Hilda asteroids were obtained at the Center for Solar System Studies (CS3) from 2017 October-December. Preliminary shape and spin axis models are given for seven of the Hildas: 958 Asplinda, 1439 Vogita, 1539 Oterma, 2483 Guinevere, 3561 Devine, 4317 Garibaldi, and 17428 Charleroi. These will serve as good starting points for future modeling.

  9. Measuring Malaysia School Resource Centers' Standards through iQ-PSS: An Online Management Information System

    Science.gov (United States)

    Zainudin, Fadzliaton; Ismail, Kamarulzaman

    2010-01-01

    The Ministry of Education has come up with an innovative way to monitor the progress of 9,843 School Resource Centers (SRCs) using an online management information system called iQ-PSS (Quality Index of SRC). This paper aims to describe the data collection method and analyze the current state of SRCs in Malaysia and explain how the results can be…

  10. Transportation Systems Center Bibliography of Technical Reports, July 1970 - December 1976,

    Science.gov (United States)

    1977-04-01

    Systems Center. AD-733-763 Judith Gertler, Herbert Glynn, Vivian Hobbs, Frederick Interim Report. June 1971. 16p. Woolfall. AD-733-764 Air Traffic Control...of Deployment Cost Analysis .. .......... FAA-76-20 Airspace Control Environmnent Simulator - Final Report.... ............ .. TSC-131.3 *All- Wether

  11. Design and implement of infrared small target real-time detection system based on pipeline technology

    Science.gov (United States)

    Sun, Lihui; Wang, Yongzhong; He, Yongqiang

    2007-01-01

    The detection for motive small target in infrared image sequence has become a hot topic nowadays. Background suppress algorithm based on minim gradient median filter and temporal recursion target detection algorithm are introduced. On the basis of contents previously mentioned, a four stages pipeline structure infrared small target detection process system, which aims at characters of algorithm complexity, large amounts of data to process, high frame frequency and exigent real-time character in this kind of application, is designed and implemented. The logical structure of the system was introduced and the function and signals flows are programmed. The system is composed of two FPGA chips and two DSP chips of TI. According to the function of each part, the system is divided into image preprocess stage, target detection stage, track relation stage and image output stage. The experiment of running algorithms on the system presented in this paper proved that the system could meet acquisition and process of 50Hz 240x320 digital image and the system could real time detect small target with a signal-noise ratio more than 3 reliably. The system achieves the characters of large amount of memory, high real-time processing, excellent extension and favorable interactive interface.

  12. ONAV - An Expert System for the Space Shuttle Mission Control Center

    Science.gov (United States)

    Mills, Malise; Wang, Lui

    1992-01-01

    The ONAV (Onboard Navigation) Expert System is being developed as a real-time console assistant to the ONAV flight controller for use in the Mission Control Center at the Johnson Space Center. Currently, Oct. 1991, the entry and ascent systems have been certified for use on console as support tools, and were used for STS-48. The rendezvous system is in verification with the goal to have the system certified for STS-49, Intelsat retrieval. To arrive at this stage, from a prototype to real-world application, the ONAV project has had to deal with not only Al issues but operating environment issues. The Al issues included the maturity of Al languages and the debugging tools, verification, and availability, stability and size of the expert pool. The environmental issues included real time data acquisition, hardware suitability, and how to achieve acceptance by users and management.

  13. Toward human-centered man-machine system in nuclear power plants

    International Nuclear Information System (INIS)

    Tanabe, Fumiya

    1993-01-01

    The Japanese LWR power plants are classified into 4 categories, from the viewpoints of the control panel in central control room and the extent of automation. Their characteristics are outlined. The potential weaknesses indwelt in the conventional approaches are discussed; that are the loss of applicability to the unanticipated facts and the loss of morale of the operators. The need for the construction of human-centered man-machine system is emphasized in order to overcome these potential weaknesses. The most important features required for the system are, in short term, to support operators in dificulties, and at the same time, in long term, to assure the acquisition and conservation of the personnels' morale and potential to cope with the problems. The concepts of the 'ecological interface' and 'adaptive aiding' system are introduced as the design concepts for the human-centered man-machine system. (J.P.N.)

  14. Automatic gas-levitation system for vacuum deposition of laser-fusion targets

    International Nuclear Information System (INIS)

    Jordan, C.W.; Cameron, G.R.; Krenik, R.M.; Crane, J.K.

    1981-01-01

    An improved simple system has been developed to gas-levitate microspheres during vacuum-deposition processes. The automatic operation relies on two effects: a lateral stabilizing force provided by a centering-ring; and an automatically incremented gas metering system to offset weight increases during coating

  15. Management Overview of System Technical Support Plan for the FIREFINDER System Support Center.

    Science.gov (United States)

    1980-08-06

    le of the noise is established on a range cell by range cell basis so that a constai false alarm rate can be established. Target detection thresholds...at the transmitter test target range cell are used to determine the trans- mitter stability. The stability is determined by a comparison of the target...r I ’s I.-0 DEVFLCfM&,NT -^D AC ’U S TION, j iTO I - FUTURE O~ S~. NT1 C, Y.M PA-I SF -1~ S APP 1 AJ ;; 31 >L7 d 10 aw APPENDIX K ENGINEERING RELEASE

  16. System for automatic x-ray-image analysis, measurement, and sorting of laser fusion targets

    International Nuclear Information System (INIS)

    Singleton, R.M.; Perkins, D.E.; Willenborg, D.L.

    1980-01-01

    This paper describes the Automatic X-Ray Image Analysis and Sorting (AXIAS) system which is designed to analyze and measure x-ray images of opaque hollow microspheres used as laser fusion targets. The x-ray images are first recorded on a high resolution film plate. The AXIAS system then digitizes and processes the images to accurately measure the target parameters and defects. The primary goals of the AXIAS system are: to provide extremely accurate and rapid measurements, to engineer a practical system for a routine production environment and to furnish the capability of automatically measuring an array of images for sorting and selection

  17. Generation of a strong core-centering force in a submillimeter compound droplet system

    International Nuclear Information System (INIS)

    Lee, M.C.; Feng, I.; Elleman, D.D.; Wang, T.G.; Young, A.T.

    1981-01-01

    By amplitude-modulating the driving voltage of an acoustic levitating apparatus, a strong core-centering force can be generated in a submillimeter compound droplet system suspended by the radiation pressure in a gaseous medium. Depending on the acoustic characteristics of the droplet system, it has been found that the technique can be utilized advantageously in the multiple-layer coating of an inertial-confinement-fusion pellet

  18. Comparative analysis on operation strategies of CCHP system with cool thermal storage for a data center

    International Nuclear Information System (INIS)

    Song, Xu; Liu, Liuchen; Zhu, Tong; Zhang, Tao; Wu, Zhu

    2016-01-01

    Highlights: • Load characteristics of the data center make a good match with CCHP systems. • TRNSYS models was used to simulate the discussed CCHP system in a data center. • Comprehensive system performance under two operation strategies were evaluated. • Cool thermal storage was introduced to reuse the energy surplus by FEL system. • The suitable principle of equipment selection for a FEL system were proposed. - Abstract: Combined Cooling, Heating, and Power (CCHP) systems with cool thermal storage can provide an appropriate energy supply for data centers. In this work, we evaluate the CCHP system performance under two different operation strategies, i.e., following thermal load (FTL) and following electric load (FEL). The evaluation is performed through a case study by using TRNSYS software. In the FEL system, the amount of cool thermal energy generated by the absorption chillers is larger than the cooling load and it can be therefore stored and reused at the off-peak times. Results indicate that systems under both operation strategies have advantages in the fields of energy saving and environmental protection. The largest percentage of reduction of primary energy consumption, CO_2 emissions, and operation cost for the FEL system, are 18.5%, 37.4% and 46.5%, respectively. Besides, the system performance is closely dependent on the equipment selection. The relation between the amount of energy recovered through cool thermal storage and the primary energy consumption has also been taken into account. Moreover, the introduction of cool thermal storage can adjust the heat to power ratio on the energy supply side close to that on the consumer side and consequently promote system flexibility and energy efficiency.

  19. Repetitive laser fusion experiment and operation using a target injection system

    International Nuclear Information System (INIS)

    Nishimura, Yasuhiko; Komeda, Osamu; Mori, Yoshitaka

    2017-01-01

    Since 2008, a collaborative research project on laser fusion development based on a high-speed ignition method using repetitive laser has been carried out with several collaborative research institutes. This paper reports the current state of operation of high repetition laser fusion experiments, such as target introduction and control based on a target injection system that allows free falling under 1 Hz, using a high repetition laser driver that has been under research and development, as well as the measurement of targets that freely fall. The HAMA laser driver that enabled high repetition fusion experiments is a titanium sapphire laser using a diode-pumped solid-state laser KURE-I of green light output as a driver pump light source. In order to carry out high repetition laser fusion experiments, the target injection device allows free falling of deuterated polystyrene solid sphere targets of 1 mm in diameter under 1 Hz. The authors integrated the developed laser and injection system, and succeeded first in the world in making the nuclear fusion reaction continuously by hitting the target to be injected with laser, which is essential technology for future laser nuclear fusion reactor. In order to realize repetition laser fusion experiments, stable laser, target synchronization control, and target position measurement technologies are indispensable. (A.O.)

  20. Rationale for a spallation neutron source target system test facility at the 1-MW Long-Pulse Spallation Source

    International Nuclear Information System (INIS)

    Sommer, W.F.

    1995-12-01

    The conceptual design study for a 1-MW Long-Pulse Spallation Source at the Los Alamos Neutron Science Center has shown the feasibility of including a spallation neutron test facility at a relatively low cost. This document presents a rationale for developing such a test bed. Currently, neutron scattering facilities operate at a maximum power of 0.2 MW. Proposed new designs call for power levels as high as 10 MW, and future transmutation activities may require as much as 200 MW. A test bed will allow assessment of target neutronics; thermal hydraulics; remote handling; mechanical structure; corrosion in aqueous, non-aqueous, liquid metal, and molten salt systems; thermal shock on systems and system components; and materials for target systems. Reliable data in these areas are crucial to the safe and reliable operation of new high-power facilities. These tests will provide data useful not only to spallation neutron sources proposed or under development, but also to other projects in accelerator-driven transmutation technologies such as the production of tritium

  1. Elemental Technologies for Lead-Bismuth Spallation Target System in J-PARC

    International Nuclear Information System (INIS)

    Obayashi, H.; Yamaguchi, K.; Saito, S.; Sugawara, T.; Takei, H.; Sasa, T.

    2015-01-01

    Japan Atomic Energy Agency (JAEA) has been researching and developing an Accelerator-Driven System (ADS) as a dedicated system for the transmutation of long-lived radioactive nuclides. The ADS proposed by JAEA uses the lead-bismuth eutectic (LBE) alloy as a spallation target material and a coolant. In the various R and D for ADS, construction of the Transmutation Experimental Facility (TEF) is planned under the framework of the J-PARC project as a preceding step before the construction of demonstrative ADS. In this R and D, TEF is considered for the experimental investigation of the feasibility of the beam window, the structural materials, and to investigate the operation properties of the target system by using 400 MeV-250 kW proton beam. This target system is consisted of various elements and must be able to operate without troubles during an operation period of TEF facility. Furthermore, in the maintenance period after the operation, because the inside of a hot cell storing a target is exposed to strong radiations, all elements must be designed as remote control devices. In this study, the present conditions of the design and the result of performance test of each important elements were confirmed in the realisation of the LBE target system, such as the monitoring system of flow rate by using the ultrasonic method, the heater system with the metallic heat insulator joined to a flow channel of LBE, and the operability of remote handing. (authors)

  2. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

    Directory of Open Access Journals (Sweden)

    Feng Jiang

    2015-10-01

    Full Text Available Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX, are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

  3. INSPACE CHEMICAL PROPULSION SYSTEMS AT NASA's MARSHALL SPACE FLIGHT CENTER: HERITAGE AND CAPABILITIES

    Science.gov (United States)

    McRight, P. S.; Sheehy, J. A.; Blevins, J. A.

    2005-01-01

    NASA s Marshall Space Flight Center (MSFC) is well known for its contributions to large ascent propulsion systems such as the Saturn V rocket and the Space Shuttle external tank, solid rocket boosters, and main engines. This paper highlights a lesser known but very rich side of MSFC-its heritage in the development of in-space chemical propulsion systems and its current capabilities for spacecraft propulsion system development and chemical propulsion research. The historical narrative describes the flight development activities associated with upper stage main propulsion systems such as the Saturn S-IVB as well as orbital maneuvering and reaction control systems such as the S-IVB auxiliary propulsion system, the Skylab thruster attitude control system, and many more recent activities such as Chandra, the Demonstration of Automated Rendezvous Technology (DART), X-37, the X-38 de-orbit propulsion system, the Interim Control Module, the US Propulsion Module, and multiple technology development activities. This paper also highlights MSFC s advanced chemical propulsion research capabilities, including an overview of the center s Propulsion Systems Department and ongoing activities. The authors highlight near-term and long-term technology challenges to which MSFC research and system development competencies are relevant. This paper concludes by assessing the value of the full range of aforementioned activities, strengths, and capabilities in light of NASA s exploration missions.

  4. The design of a lead-bismuth target system with a dual injection tube

    International Nuclear Information System (INIS)

    Cho, C.H.; Kim, Y.; Song, T.Y.; Park, W.S.

    2005-01-01

    A spallation target system is a key component to be developed for an accelerator driven system (ADS). It is known that a 15 ∼ 25 MW spallation target is required for a practical 1000 MWth ADS. The design of a 20 MW spallation target is very challenging because more than 60% of the beam power is deposited as heat in a small volume of the target system. In the present work, a numerical design study was performed to obtain the optimal design parameters for a 20 MW spallation target for a 1000 MW ADS. A dual injection tube was proposed for the reduction of the LBE flow rate at the target channel. The results of the present study show that a 30 cm wide proton beam with a uniform beam distribution should be adopted for the spallation target of a 20 MW power. When the dual LBE injection tube is employed, the LBE flow rate could be reduced by a factor of 4 without reducing the maximum allowable beam current. (authors)

  5. High-Speed Target Identification System Based on the Plume’s Spectral Distribution

    Directory of Open Access Journals (Sweden)

    Wenjie Lang

    2015-01-01

    Full Text Available In order to recognize the target of high speed quickly and accurately, an identification system was designed based on analysis of the distribution characteristics of the plume spectrum. In the system, the target was aligned with visible light tracking module, and the spectral analysis of the target’s plume radiation was achieved by interference module. The distinguishing factor recognition algorithm was designed on basis of ratio of multifeature band peaks and valley mean values. Effective recognition of the high speed moving target could be achieved after partition of the active region and the influence of target motion on spectral acquisition was analyzed. In the experiment the small rocket combustion was used as the target. The spectral detection experiment was conducted at different speeds 2.0 km away from the detection system. Experimental results showed that spectral distribution had significant spectral offset in the same sampling period for the target with different speeds, but the spectral distribution was basically consistent. Through calculation of the inclusion relationship between distinguishing factor and distinction interval of the peak value and the valley value at the corresponding wave-bands, effective identification of target could be achieved.

  6. Python-Based Scientific Analysis and Visualization of Precipitation Systems at NASA Marshall Space Flight Center

    Science.gov (United States)

    Lang, Timothy J.

    2015-01-01

    larger regional or national picture of precipitating weather systems. Composites, horizontal and vertical crosssections, and combinations thereof are easily displayed using as little as one line of code. MMM-Py can also write to the native MRMS binary format, and sub-sectioning of tiles (or multiple stitched tiles) is anticipated to be in place by the time of this meeting. Thus, MMM-Py also can be used to power the creation of custom mosaics for targeted regional studies. Overlays of other data (e.g., lightning observations) are easily accomplished. Demonstrations of MMM-Py, including the creation of animations, will be shown. Finally, Marshall has done significant work to interface Python-based analysis routines with the U.S. Department of Energy's Py-ART software package for radar data ingest, processing, and analysis. One example of this is the Python Turbulence Detection Algorithm (PyTDA), an MSFC-based implementation of the National Center for Atmospheric Research (NCAR) Turbulence Detection Algorithm (NTDA) for the purposes of convective-scale analysis, situational awareness, and forensic meteorology. PyTDA exploits Py-ART's radar data ingest routines and data model to rapidly produce aviation-relevant turbulence estimates from Doppler radar data. Work toward processing speed optimization and better integration within the Py-ART framework will be highlighted. Python-based analysis within the Py-ART framework is also being done for new research related to intercomparison of ground-based radar data with satellite estimates of ocean winds, as well as research on the electrification of pyrocumulus clouds.

  7. Nanobody-Based Delivery Systems for Diagnosis and Targeted Tumor Therapy

    Directory of Open Access Journals (Sweden)

    Yaozhong Hu

    2017-11-01

    Full Text Available The development of innovative targeted therapeutic approaches are expected to surpass the efficacy of current forms of treatments and cause less damage to healthy cells surrounding the tumor site. Since the first development of targeting agents from hybridoma’s, monoclonal antibodies (mAbs have been employed to inhibit tumor growth and proliferation directly or to deliver effector molecules to tumor cells. However, the full potential of such a delivery strategy is hampered by the size of mAbs, which will obstruct the targeted delivery system to access the tumor tissue. By serendipity, a new kind of functional homodimeric antibody format was discovered in camelidae, known as heavy-chain antibodies (HCAbs. The cloning of the variable domain of HCAbs produces an attractive minimal-sized alternative for mAbs, referred to as VHH or nanobodies (Nbs. Apart from their dimensions in the single digit nanometer range, the unique characteristics of Nbs combine a high stability and solubility, low immunogenicity and excellent affinity and specificity against all possible targets including tumor markers. This stimulated the development of tumor-targeted therapeutic strategies. Some autonomous Nbs have been shown to act as antagonistic drugs, but more importantly, the targeting capacity of Nbs has been exploited to create drug delivery systems. Obviously, Nb-based targeted cancer therapy is mainly focused toward extracellular tumor markers, since the membrane barrier prevents antibodies to reach the most promising intracellular tumor markers. Potential strategies, such as lentiviral vectors and bacterial type 3 secretion system, are proposed to deliver target-specific Nbs into tumor cells and to block tumor markers intracellularly. Simultaneously, Nbs have also been employed for in vivo molecular imaging to diagnose diseased tissues and to monitor the treatment effects. Here, we review the state of the art and focus on recent developments with Nbs as

  8. A knowledge continuity management program for the energy, infrastructure and knowledge systems center, Sandia National Laboratories.

    Energy Technology Data Exchange (ETDEWEB)

    Menicucci, David F.

    2006-07-01

    A growing recognition exists in companies worldwide that, when employees leave, they take with them valuable knowledge that is difficult and expensive to recreate. The concern is now particularly acute as the large ''baby boomer'' generation is reaching retirement age. A new field of science, Knowledge Continuity Management (KCM), is designed to capture and catalog the acquired knowledge and wisdom from experience of these employees before they leave. The KCM concept is in the final stages of being adopted by the Energy, Infrastructure, and Knowledge Systems Center and a program is being applied that should produce significant annual cost savings. This report discusses how the Center can use KCM to mitigate knowledge loss from employee departures, including a concise description of a proposed plan tailored to the Center's specific needs and resources.

  9. The design of neonatal incubators: a systems-oriented, human-centered approach.

    Science.gov (United States)

    Ferris, T K; Shepley, M M

    2013-04-01

    This report describes a multidisciplinary design project conducted in an academic setting reflecting a systems-oriented, human-centered philosophy in the design of neonatal incubator technologies. Graduate students in Architectural Design and Human Factors Engineering courses collaborated in a design effort that focused on supporting the needs of three user groups of incubator technologies: infant patients, family members and medical personnel. Design teams followed established human-centered design methods that included interacting with representatives from the user groups, analyzing sets of critical tasks and conducting usability studies with existing technologies. An iterative design and evaluation process produced four conceptual designs of incubators and supporting equipment that better address specific needs of the user groups. This report introduces the human-centered design approach, highlights some of the analysis findings and design solutions, and offers a set of design recommendations for future incubation technologies.

  10. Enhancement of the efficiency of magnetic targeting for drug delivery: Development and evaluation of magnet system

    International Nuclear Information System (INIS)

    Cao Quanliang; Han Xiaotao; Li Liang

    2011-01-01

    Deep magnetic capture and clinical application are the current trends for magnetic targeted drug delivery system. More promising and possible strategies are needed to overcome the current limitations and further improve the magnetic targeting technique. Recent advances in the development of targeting magnet system show promise in progressing this technology from the laboratory to the clinic. Starting from well-known basic concepts, current limitations of magnetic targeted drug delivery system are analyzed. Meanwhile, the design concepts and evaluations of some effective improvements in magnet system are discussed and reviewed with reference to (i) reasonable design of magnet system; (ii) control modes of magnet system used to generate dynamical magnetic fields; and (iii) magnetic field driving types. - Research Highlights: → The current limitations of MTDDS for deep capture and clinical application are analyzed. → The development of magnet system shows promise in progressing MTDDS to clinical application. → The design concepts and evaluations of improvements in magnet system are reviewed and discussed. → The key to improve magnet system lies in controllable magnets and different excitations.

  11. Spallation Neutron Source Accelerator Facility Target Safety and Non-safety Control Systems

    International Nuclear Information System (INIS)

    Battle, Ronald E.; DeVan, B.; Munro, John K. Jr.

    2006-01-01

    The Spallation Neutron Source (SNS) is a proton accelerator facility that generates neutrons for scientific researchers by spallation of neutrons from a mercury target. The SNS became operational on April 28, 2006, with first beam on target at approximately 200 W. The SNS accelerator, target, and conventional facilities controls are integrated by standardized hardware and software throughout the facility and were designed and fabricated to SNS conventions to ensure compatibility of systems with Experimental Physics Integrated Control System (EPICS). ControlLogix Programmable Logic Controllers (PLCs) interface to instruments and actuators, and EPICS performs the high-level integration of the PLCs such that all operator control can be accomplished from the Central Control room using EPICS graphical screens that pass process variables to and from the PLCs. Three active safety systems were designed to industry standards ISA S84.01 and IEEE 603 to meet the desired reliability for these safety systems. The safety systems protect facility workers and the environment from mercury vapor, mercury radiation, and proton beam radiation. The facility operators operated many of the systems prior to beam on target and developed the operating procedures. The safety and non-safety control systems were tested extensively prior to beam on target. This testing was crucial to identify wiring and software errors and failed components, the result of which was few problems during operation with beam on target. The SNS has continued beam on target since April to increase beam power, check out the scientific instruments, and continue testing the operation of facility subsystems

  12. Energy Center Structure Optimization by using Smart Technologies in Process Control System

    Science.gov (United States)

    Shilkina, Svetlana V.

    2018-03-01

    The article deals with practical application of fuzzy logic methods in process control systems. A control object - agroindustrial greenhouse complex, which includes its own energy center - is considered. The paper analyzes object power supply options taking into account connection to external power grids and/or installation of own power generating equipment with various layouts. The main problem of a greenhouse facility basic process is extremely uneven power consumption, which forces to purchase redundant generating equipment idling most of the time, which quite negatively affects project profitability. Energy center structure optimization is largely based on solving the object process control system construction issue. To cut investor’s costs it was proposed to optimize power consumption by building an energy-saving production control system based on a fuzzy logic controller. The developed algorithm of automated process control system functioning ensured more even electric and thermal energy consumption, allowed to propose construction of the object energy center with a smaller number of units due to their more even utilization. As a result, it is shown how practical use of microclimate parameters fuzzy control system during object functioning leads to optimization of agroindustrial complex energy facility structure, which contributes to a significant reduction in object construction and operation costs.

  13. Cannonball target experiment with the GEKKO laser system at ILE Osaka

    International Nuclear Information System (INIS)

    Yamanaka, C.; Azechi, H.; Fujiwara, E.

    1985-01-01

    The GEKKO series glass laser systems are now in operation for the Cannonball target experiments. GEKKO XII is a twelve-beam 30 kJ, 50 TW laser provided with two target chambers. Three types of GEKKO lasers cover the UV, blue, green and red frequency ranges. The Cannonball target displays an excellent performance in implosion. Two kinds of Cannonball target are proposed: the plasma Cannonball and the radiation Cannonball. The neutron yield is 4x10 10 , and the DT fuel density attains 10 g.cm -3 . Laser-to-X-ray conversion has been investigated. Cryogenic target implosion has been performed by using a tailored laser pulse to produce the flush at the core. Various kinds of new diagnostics are being developed. (author)

  14. A Statewide Collaboration: Ohio Level III Trauma Centers' Approach to the Development of a Benchmarking System.

    Science.gov (United States)

    Lang, Carrie L; Simon, Diane; Kilgore, Jane

    The American College of Surgeons Committee on Trauma revised the Resources for Optimal Care of the Injured Patient to include the criteria for trauma centers to participate in a risk-adjusted benchmarking system. Trauma Quality Improvement Program is currently the risk-adjusted benchmarking program sponsored by the American College of Surgeons, which will be required of all trauma centers to participate in early 2017. Prior to this, there were no risk-adjusted programs for Level III verified trauma centers. The Ohio Society of Trauma Nurse Leaders is a collaborative group made up of trauma program managers, coordinators, and other trauma leaders who meet 6 times a year. Within this group, a Level III Subcommittee was formed initially to provide a place for the Level III centers to discuss issues specific to the Level III centers. When the new requirement regarding risk-adjustment became official, the subcommittee agreed to begin reporting simple data points with the idea to risk adjust in the future.

  15. What do we mean by Human-Centered Design of Life-Critical Systems?

    Science.gov (United States)

    Boy, Guy A

    2012-01-01

    Human-centered design is not a new approach to design. Aerospace is a good example of a life-critical systems domain where participatory design was fully integrated, involving experimental test pilots and design engineers as well as many other actors of the aerospace engineering community. This paper provides six topics that are currently part of the requirements of the Ph.D. Program in Human-Centered Design of the Florida Institute of Technology (FIT.) This Human-Centered Design program offers principles, methods and tools that support human-centered sustainable products such as mission or process control environments, cockpits and hospital operating rooms. It supports education and training of design thinkers who are natural leaders, and understand complex relationships among technology, organizations and people. We all need to understand what we want to do with technology, how we should organize ourselves to a better life and finally find out whom we are and have become. Human-centered design is being developed for all these reasons and issues.

  16. An underwater ranging system based on photoacoustic effect occurring on target surface

    Science.gov (United States)

    Ni, Kai; Hu, Kai; Li, Xinghui; Wang, Lidai; Zhou, Qian; Wang, Xiaohao

    2016-11-01

    In this paper, an underwater ranging system based on photoacoustic effect occurring on target surface is proposed. In this proposal, laser pulse generated by blue-green laser is directly incident on target surface, where the photoacoustic effect occurs and a sound source is formed. And then the sound wave which is also called photoacoustic signal is received by the ultrasonic receiver after passing through water. According to the time delay between transmitting laser and receiving photoacoustic signal, and sound velocity in water, the distance between the target and the ultrasonic receiver can be calculated. Differing from underwater range finding by only laser, this approach can avoid backscattering of laser beam, so easier to implement. Experimental system according to this principle has been constructed to verify the feasibility of this technology. The experimental results showed that a ranging accuracy of 1 mm can be effectively achieved when the target is close to the ultrasonic receiver.

  17. Analysis of the Neutron Generator and Target for the LSDTS System

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chang Je; Lee, Yong Deok; Song, Jae Hoon; Song, Kee Chan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-11-15

    A preliminary analysis was performed based on the literatures and the patents for the neutron generators and targets for the lead slowing down time spectrometer (LSDTS) system. It was found that local neutron generator did not exhibit enough neutron intensity such as 1E+12 n/s, which is a minimum requirement for the LSDTS system to overcome curium backgrounds. However, a neutron generator implemented with an electron accelerator may provide a higher intensity around 1E+13 n/s and it is required to investigate further including a detail analysis. In addition to the neutron generator, a study on target was performed with the Monte Carlo simulation. In the study, an optimal design of target was suggested to provide a high neutron yield and a better thermal resistance. The suggested target consists several cylindrical plates with a certain cooling gap, which have increasing thickness and increasing radius.

  18. [The research on a pocket microcontroller system for target controlled infusion].

    Science.gov (United States)

    Cheng, Yu-Ke; Zhang, Xin-An; Zhang, Yan-Wu; Wu, Qun-Ling; Dou, Jian-Hong; Wang, Rou-Shong

    2005-05-01

    This paper present a microcontroller system for target controlled infusion according to pharmacodynamic parameters of intravenous anesthetics. It can control the depth of anesthesia by adjusting the level of plasma concentrations. The system has the advantages of high precision, extended function and easy operation. It has been now used in the clinical anesthesia.

  19. [Toxicological consultation data management system based on experience of Pomeranian Center of Toxicology].

    Science.gov (United States)

    Kabata, Piotr Maciej; Waldman, Wojciech; Sein Anand, Jacek

    2015-01-01

    In this paper the structure of poisonings is described, based on the material collected from tele-toxicology consults by the Pomeranian Center of Toxicology in Gdańsk and harvested from its Electronic Poison Information Management System. In addition, we analyzed conclusions drawn from a 27-month operation of the system. Data were harvested from the Electronic Poison Information Management System developed in 2012 and used by the Pomeranian Center of Toxicology since then. The research was based on 2550 tele-toxicology consults between January 1 and December 31, 2014. Subsequently the data were electronically cleaned and presented using R programming language. The Pomeranian voivodeship was the prevalent localisation of calls (N = 1879; 73.7%). Most of the calls came from emergency rooms (N = 1495; 58.63%). In the case of 1396 (54.7%) patients the time-lag between intoxication and the consult was less than 6 h. There were no differences in the age distribution between genders. Mean age was 26.3 years. Young people predominated among intoxicated individuals. The majority of intoxications were incidental (N = 888; 34.8%) or suicidal (N = 814; 31.9%) and the most of them took place in the patient's home. Information about Poison Control Center consultations access should be better spread among medical service providers. The extent of poison information collected by Polish Poison Control Centers should be limited and unified. This should contribute to the increased percentage of properly documented consultations. Additional duties stemming from the need of digital archiving of consults provided, require the involvement of additional staff, leading to the increased operation costs incurred by Poison Control Centers. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  20. A liquid He-3 target system for use at intermediate energies

    International Nuclear Information System (INIS)

    Hassell, D.K.; Abegg, R.; Murdoch, B.T.; van Oers, W.J.H.; Soukup, J.

    1981-04-01

    A liquid 3 He target system with remote instrumentation and handling capabilities has been developed for experiments using the 180-525 MeV TRIUMF cyclotron. Helium-3 gas is liquefied by means of a 4 He cryostat into a cylindrical target cell (4.4 cm diameter, 1.6 cm thick) and maintained during operation at approximately 1.6 K. This provides an areal target density of approximately 2.7 x 10 22 He-3 nuclei/cm 2 (128 mg/cm 2 ), suitable for intermediate energy proton scattering. (author)

  1. Some physical magnitudes of interest for nuclear reactions and their dependence on the projectile-target system

    International Nuclear Information System (INIS)

    Fernandez Niello, J.O.; Pacheco, A.J.

    1984-01-01

    The design and analysis of experiences with heavy ions requires the knwoledge of several characteristic parameters of the collision and their dependence on the reactant system. In the case of an electrostatic accelerator as the TANDAR, the bombarding energy (function of the projectile) is a direct consequence of the evolution of the charged state distribution for the projectile at the exit of the last stripper, as a function of the atomic number. The complexity resulting from this dependence originated the confection of a series of diagrams. The diagrams correpond to the different physical magnitudes of interest in the analysis of nuclear reactions as a function of the projectile-target combination for terminal tensions similar to those expected to reach at the TANDAR. In each case, the curves are refered to the following physical magnitudes: Ecm/Bc Kinetic energy in the center of the mass system and Coulomb barrier for the projectile-target system, Lgr = angular momentum corresponding to the grazing collisions. Diagrams of the average projectile energy per nucleon for the different values of the terminal tensions with one or two solid strippers are included. The use of the diagrams in some practical applications is illustrated through four examples. The diagrams may be extended, if necesary, to other physical magnitudes, at different accelerator's operating conditions. (M.E.L.) [es

  2. NASA-Langley Research Center's Aircraft Condition Analysis and Management System Implementation

    Science.gov (United States)

    Frye, Mark W.; Bailey, Roger M.; Jessup, Artie D.

    2004-01-01

    This document describes the hardware implementation design and architecture of Aeronautical Radio Incorporated (ARINC)'s Aircraft Condition Analysis and Management System (ACAMS), which was developed at NASA-Langley Research Center (LaRC) for use in its Airborne Research Integrated Experiments System (ARIES) Laboratory. This activity is part of NASA's Aviation Safety Program (AvSP), the Single Aircraft Accident Prevention (SAAP) project to develop safety-enabling technologies for aircraft and airborne systems. The fundamental intent of these technologies is to allow timely intervention or remediation to improve unsafe conditions before they become life threatening.

  3. Design and performance of the Georgia Tech Aquatic Center photovoltaic system. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Rohatgi, A.; Begovic, M.; Long, R.; Ropp, M.; Pregelj, A.

    1996-12-31

    A building-integrated DC PV array has been constructed on the Georgia Tech campus. The array is mounted on the roof of the Georgia Tech Aquatic Center (GTAC), site of the aquatic events during the 1996 Paralympic and Olympic Games in Atlanta. At the time of its construction, it was the world`s largest roof-mounted photovoltaic array, comprised of 2,856 modules and rates at 342 kW. This section describes the electrical and physical layout of the PV system, and the associated data acquisition system (DAS) which monitors the performance of the system and collects measurements of several important meteorological parameters.

  4. ORAL COLON TARGETED DRUG DELIVERY SYSTEM: A REVIEW ON CURRENT AND NOVEL PERSPECTIVES

    OpenAIRE

    Asija Rajesh; Chaudhari Bharat; Asija Sangeeta

    2012-01-01

    Small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to colon due to some factors like local colonic disease, degradation related conditions, delayed release of drugs, systemic delivery of protein and peptide drugs etc. Colon targeted drug delivery is important and relatively new concept for the absorption of drugs because it offers almost neutral pH and long residence time, thereby increasing the drug absorption. Colon has proved to be a site...

  5. CFD Study of the Active Part of the HYPER LBE Spallation Target System

    International Nuclear Information System (INIS)

    Cho, Chung-ho; Tak, Nam-il; Lee, Yong-bum; Choi, Jae-Hyuk

    2007-01-01

    In an accelerator driven system (ADS), a high-energy proton beam impinges on a heavy metal target to produce spallation neutrons that are multiplied in a subcritical blanket. Therefore, the spallation target is one of the most important units of an ADS. A beam power of 15-25 MW is required for an operation of the HYPER system. But, the design of a 20 MW spallation target is very challenging because more than 60% of a beam power is deposited as heat in a small volume of a target system. LBE is preferred as the target material due to its high neutron production rate, effective heat removal, low melting point and vapor pressure, low neutron absorption and good radiation damage properties. In addition, it can be used simultaneously as a reactor coolant. Single hemi-spherical beam window is considered for the HYPER target. The beam window is a thin physical barrier to separate the vacuum space from the LBE. It is exposed to high thermal and irradiation loads, which affect its life time. The integrity of the beam window is crucial for a safe operation of the HYPER, for preventing the penetration of the radioactive spallation products into the accelerator island. Therefore, a sufficient cooling capability of the beam window is one of the key issues of the target design. In the previous study, a series of parametric thermal and mechanical studies were made for the optimization of the HYPER target. The optimized target has a 0.2 cm thick beam window with a diameter of 35 cm. Also, a 30 cm wide proton beam with a uniform beam distribution should be adopted for the spallation target of the HYPER. A dual injection tube is adopted to economize the LBE flow in the primary system. This paper presents the numerical studies on the optimized spallation target system. Several advanced turbulence models with different grid structures are investigated by using a commercial computational fluid dynamics (CFD) code CFX 5.7.1

  6. The application of carbon nanotubes in target drug delivery systems for cancer therapies

    Science.gov (United States)

    Zhang, Wuxu; Zhang, Zhenzhong; Zhang, Yingge

    2011-10-01

    Among all cancer treatment options, chemotherapy continues to play a major role in killing free cancer cells and removing undetectable tumor micro-focuses. Although chemotherapies are successful in some cases, systemic toxicity may develop at the same time due to lack of selectivity of the drugs for cancer tissues and cells, which often leads to the failure of chemotherapies. Obviously, the therapeutic effects will be revolutionarily improved if human can deliver the anticancer drugs with high selectivity to cancer cells or cancer tissues. This selective delivery of the drugs has been called target treatment. To realize target treatment, the first step of the strategies is to build up effective target drug delivery systems. Generally speaking, such a system is often made up of the carriers and drugs, of which the carriers play the roles of target delivery. An ideal carrier for target drug delivery systems should have three pre-requisites for their functions: (1) they themselves have target effects; (2) they have sufficiently strong adsorptive effects for anticancer drugs to ensure they can transport the drugs to the effect-relevant sites; and (3) they can release the drugs from them in the effect-relevant sites, and only in this way can the treatment effects develop. The transporting capabilities of carbon nanotubes combined with appropriate surface modifications and their unique physicochemical properties show great promise to meet the three pre-requisites. Here, we review the progress in the study on the application of carbon nanotubes as target carriers in drug delivery systems for cancer therapies.

  7. Preconceptual design of a Long-Pulse Spallation Source (LPSS) at the LANSCE Facility: Target system, facility, and material handling considerations

    International Nuclear Information System (INIS)

    Sommer, W.F.

    1995-12-01

    This report provides a summary of a preconceptual design study for the proposed Long-Pulse Spallation. Source (LPSS) at the Los Alamos Neutron Science Center (LANSCE). The LPSS will use a 0.8-MW proton beam to produce neutrons from a tungsten target. This study focuses on the design of the target station and changes to the existing building that would be made to accommodate the LPSS. The LPSS will provide fifteen flight paths to neutron scattering instruments. In addition, options for generating ultracold neutrons, pions, and muons will be available. Flight-energy, forward-scattered neutrons on the downstream side of the target will also be available for autoradiography studies. A Target Test Bed (TTB) is also proposed for full-beam tests of component materials and advanced spallation neutron sources. The design allows for separation of the experiment hall from the beam line, target, and flight paths. The target and moderator systems and the systems/components to be tested in the TTB will be emplaced and removed separately by remotely operated, shielded equipment. Irradiated materials will be transported to a hot cell adjacent to the target chamber for testing by remotely operated instruments. These tests will provide information about how materials properties are affected by proton and neutron beams

  8. Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

    Science.gov (United States)

    Kydd, Janel; Jadia, Rahul; Velpurisiva, Praveena; Gad, Aniket; Paliwal, Shailee; Rai, Prakash

    2017-01-01

    Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment—due to the hostile tumor microenvironment—that create a significant challenge for effective therapeutic regimens. Multidrug resistance, collateral toxicity to normal cells, and detrimental systemic side effects present significant obstacles, necessitating alternative and safer treatment strategies. Traditional administration of chemotherapeutics has demonstrated minimal success due to the non-specificity of action, uptake and rapid clearance by the immune system, and subsequent metabolic alteration and poor tumor penetration. Nanomedicine can provide a more effective approach to targeting cancer by focusing on the vascular, tissue, and cellular characteristics that are unique to solid tumors. Targeted methods of treatment using nanoparticles can decrease the likelihood of resistant clonal populations of cancerous cells. Dual encapsulation of chemotherapeutic drug allows simultaneous targeting of more than one characteristic of the tumor. Several first-generation, non-targeted nanomedicines have received clinical approval starting with Doxil® in 1995. However, more than two decades later, second-generation or targeted nanomedicines have yet to be approved for treatment despite promising results in pre-clinical studies. This review highlights recent studies using targeted nanoparticles for cancer treatment focusing on approaches that target either the tumor vasculature (referred to as ‘vascular targeting’), the tumor microenvironment (‘tissue targeting’) or the individual cancer cells (‘cellular targeting’). Recent studies combining these different targeting methods are also discussed in this review. Finally, this review summarizes some of the reasons for the lack of clinical success in the field of targeted nanomedicines. PMID:29036899

  9. Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

    Directory of Open Access Journals (Sweden)

    Janel Kydd

    2017-10-01

    Full Text Available Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment—due to the hostile tumor microenvironment—that create a significant challenge for effective therapeutic regimens. Multidrug resistance, collateral toxicity to normal cells, and detrimental systemic side effects present significant obstacles, necessitating alternative and safer treatment strategies. Traditional administration of chemotherapeutics has demonstrated minimal success due to the non-specificity of action, uptake and rapid clearance by the immune system, and subsequent metabolic alteration and poor tumor penetration. Nanomedicine can provide a more effective approach to targeting cancer by focusing on the vascular, tissue, and cellular characteristics that are unique to solid tumors. Targeted methods of treatment using nanoparticles can decrease the likelihood of resistant clonal populations of cancerous cells. Dual encapsulation of chemotherapeutic drug allows simultaneous targeting of more than one characteristic of the tumor. Several first-generation, non-targeted nanomedicines have received clinical approval starting with Doxil® in 1995. However, more than two decades later, second-generation or targeted nanomedicines have yet to be approved for treatment despite promising results in pre-clinical studies. This review highlights recent studies using targeted nanoparticles for cancer treatment focusing on approaches that target either the tumor vasculature (referred to as ‘vascular targeting’, the tumor microenvironment (‘tissue targeting’ or the individual cancer cells (‘cellular targeting’. Recent studies combining these different targeting methods are also discussed in this review. Finally, this review summarizes some of the reasons for the lack of clinical success in the field of targeted nanomedicines.

  10. Space and Missile Systems Center Standard: Test Requirements for Launch, Upper-Stage and Space Vehicles

    Science.gov (United States)

    2014-09-05

    Aviation Blvd. El Segundo, CA 90245 4. This standard has been approved for use on all Space and Missile Systems Center/Air Force Program...140 Satellite Hardness and Survivability; Testing Rationale for Electronic Upset and Burnout Effects 30. JANNAF-GL-2012-01-RO Test and Evaluation...vehicle, subsystem, and unit lev- els . Acceptance testing shall be conducted on all subsequent flight items. The protoqualification strategy shall require

  11. Solid Waste Processing Center Primary Opening Cells Systems, Equipment and Tools

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, Sharon A.; Baker, Carl P.; Mullen, O Dennis; Valdez, Patrick LJ

    2006-04-17

    This document addresses the remote systems and design integration aspects of the development of the Solid Waste Processing Center (SWPC), a facility to remotely open, sort, size reduce, and repackage mixed low-level waste (MLLW) and transuranic (TRU)/TRU mixed waste that is either contact-handled (CH) waste in large containers or remote-handled (RH) waste in various-sized packages.

  12. High-level waste solidification system for the Western New York Nuclear Service Center

    International Nuclear Information System (INIS)

    Carrell, J.R.; Holton, L.K.; Siemens, D.H.

    1982-01-01

    A preconceptual design for a waste conditioning and solidification system for the immobilization of the high-level liquid wastes (HLLW) stored at the Western New York Nuclear Service Center (WNYNSC), West Valley, New York was completed in 1981. The preconceptual design was conducted as part of the Department of Energy's (DOE) West Valley Demonstration Project, which requires a waste management demonstration at the WNYNSC. This paper summarizes the bases, assumptions, results and conclusions of the preconceptual design study

  13. Passive Target Tracking in Non-cooperative Radar System Based on Particle Filtering

    Institute of Scientific and Technical Information of China (English)

    LI Shuo; TAO Ran

    2006-01-01

    We propose a target tracking method based on particle filtering(PF) to solve the nonlinear non-Gaussian target-tracking problem in the bistatic radar systems using external radiation sources. Traditional nonlinear state estimation method is extended Kalman filtering (EKF), which is to do the first level Taylor series extension. It will cause an inaccuracy or even a scatter estimation result on condition that there is either a highly nonlinear target or a large noise square-error. Besides, Kalman filtering is the optimal resolution under a Gaussian noise assumption, and is not suitable to the non-Gaussian condition. PF is a sort of statistic filtering based on Monte Carlo simulation that is using some random samples (particles) to simulate the posterior probability density of system random variables. This method can be used in any nonlinear random system. It can be concluded through simulation that PF can achieve higher accuracy than the traditional EKF.

  14. Technology Transfer Challenges: A Case Study of User-Centered Design in NASA's Systems Engineering Culture

    Science.gov (United States)

    Quick, Jason

    2009-01-01

    The Upper Stage (US) section of the National Aeronautics and Space Administration's (NASA) Ares I rocket will require internal access platforms for maintenance tasks performed by humans inside the vehicle. Tasks will occur during expensive critical path operations at Kennedy Space Center (KSC) including vehicle stacking and launch preparation activities. Platforms must be translated through a small human access hatch, installed in an enclosed worksite environment, support the weight of ground operators and be removed before flight - and their design must minimize additional vehicle mass at attachment points. This paper describes the application of a user-centered conceptual design process and the unique challenges encountered within NASA's systems engineering culture focused on requirements and "heritage hardware". The NASA design team at Marshall Space Flight Center (MSFC) initiated the user-centered design process by studying heritage internal access kits and proposing new design concepts during brainstorming sessions. Simultaneously, they partnered with the Technology Transfer/Innovative Partnerships Program to research inflatable structures and dynamic scaffolding solutions that could enable ground operator access. While this creative, technology-oriented exploration was encouraged by upper management, some design stakeholders consistently opposed ideas utilizing novel, untested equipment. Subsequent collaboration with an engineering consulting firm improved the technical credibility of several options, however, there was continued resistance from team members focused on meeting system requirements with pre-certified hardware. After a six-month idea-generating phase, an intensive six-week effort produced viable design concepts that justified additional vehicle mass while optimizing the human factors of platform installation and use. Although these selected final concepts closely resemble heritage internal access platforms, challenges from the application of the

  15. Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system.

    Science.gov (United States)

    Liang, Zhen; Zhang, Kang; Chen, Kunling; Gao, Caixia

    2014-02-20

    Transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems have emerged as powerful tools for genome editing in a variety of species. Here, we report, for the first time, targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system. We designed five TALENs targeting 4 genes, namely ZmPDS, ZmIPK1A, ZmIPK, ZmMRP4, and obtained targeting efficiencies of up to 23.1% in protoplasts, and about 13.3% to 39.1% of the transgenic plants were somatic mutations. Also, we constructed two gRNAs targeting the ZmIPK gene in maize protoplasts, at frequencies of 16.4% and 19.1%, respectively. In addition, the CRISPR/Cas system induced targeted mutations in Z. mays protoplasts with efficiencies (13.1%) similar to those obtained with TALENs (9.1%). Our results show that both TALENs and the CRISPR/Cas system can be used for genome modification in maize. Copyright © 2013. Published by Elsevier Ltd.

  16. An Analytic Model for the Success Rate of a Robotic Actuator System in Hitting Random Targets.

    Science.gov (United States)

    Bradley, Stuart

    2015-11-20

    Autonomous robotic systems are increasingly being used in a wide range of applications such as precision agriculture, medicine, and the military. These systems have common features which often includes an action by an "actuator" interacting with a target. While simulations and measurements exist for the success rate of hitting targets by some systems, there is a dearth of analytic models which can give insight into, and guidance on optimization, of new robotic systems. The present paper develops a simple model for estimation of the success rate for hitting random targets from a moving platform. The model has two main dimensionless parameters: the ratio of actuator spacing to target diameter; and the ratio of platform distance moved (between actuator "firings") to the target diameter. It is found that regions of parameter space having specified high success are described by simple equations, providing guidance on design. The role of a "cost function" is introduced which, when minimized, provides optimization of design, operating, and risk mitigation costs.

  17. Improving energy efficiency of dedicated cooling system and its contribution towards meeting an energy-optimized data center

    International Nuclear Information System (INIS)

    Cho, Jinkyun; Kim, Yundeok

    2016-01-01

    Highlights: • Energy-optimized data center’s cooling solutions were derived for four different climate zones. • We studied practical technologies of green data center that greatly improved energy efficiency. • We identified the relationship between mutually dependent factors in datacenter cooling systems. • We evaluated the effect of the dedicated cooling system applications. • Power Usage Effectiveness (PUE) was computed with energy simulation for data centers. - Abstract: Data centers are approximately 50 times more energy-intensive than general buildings. The rapidly increasing energy demand for data center operation has motivated efforts to better understand data center electricity use and to identify strategies that reduce the environmental impact. This research is presented analytical approach to the energy efficiency optimization of high density data center, in a synergy with relevant performance analysis of corresponding case study. This paper builds on data center energy modeling efforts by characterizing climate and cooling system differences among data centers and then evaluating their consequences for building energy use. Representative climate conditions for four regions are applied to data center energy models for several different prototypical cooling types. This includes cooling system, supplemental cooling solutions, design conditions and controlling the environment of ICT equipment were generally used for each climate zone, how these affect energy efficiency, and how the prioritization of system selection is derived. Based on the climate classification and the required operating environmental conditions for data centers suggested by the ASHRAE TC 9.9, a dedicated data center energy evaluation tool was taken to examine the potential energy savings of the cooling technology. Incorporating economizer use into the cooling systems would increase the variation in energy efficiency among geographic regions, indicating that as data centers

  18. Cetuximab-conjugated nanodiamonds drug delivery system for enhanced targeting therapy and 3D Raman imaging.

    Science.gov (United States)

    Li, Dandan; Chen, Xin; Wang, Hong; Liu, Jie; Zheng, Meiling; Fu, Yang; Yu, Yuan; Zhi, Jinfang

    2017-12-01

    In this study, a multicomponent nanodiamonds (NDs)-based targeting drug delivery system, cetuximab-NDs-cisplatin bioconjugate, combining both specific targeting and enhanced therapeutic efficacy capabilities, is developed and characterized. The specific targeting ability of cetuximab-NDs-cisplatin system on human liver hepatocellular carcinoma (HepG2) cells is evaluated through epidermal growth factor receptor (EGFR) blocking experiments, since EGFR is over-expressed on HepG2 cell membrane. Besides, cytotoxic evaluation confirms that cetuximab-NDs-cisplatin system could significantly inhibit the growth of HepG2 cells, and the therapeutic activity of this system is proven to be better than that of both nonspecific NDs-cisplatin conjugate and specific EGF-NDs-cisplatin conjugate. Furthermore, a 3-dimensional (3D) Raman imaging technique is utilized to visualize the targeting efficacy and enhanced internalization of cetuximab-NDs-cisplatin system in HepG2 cells, using the NDs existing in the bioconjugate as Raman probes, based on the characteristic Raman signal of NDs at 1332 cm -1 . These advantageous properties of cetuximab-NDs-cisplatin system propose a prospective imaging and treatment tool for further diagnostic and therapeutic purposes. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. A knowledge based expert system for propellant system monitoring at the Kennedy Space Center

    Science.gov (United States)

    Jamieson, J. R.; Delaune, C.; Scarl, E.

    1985-01-01

    The Lox Expert System (LES) is the first attempt to build a realtime expert system capable of simulating the thought processes of NASA system engineers, with regard to fluids systems analysis and troubleshooting. An overview of the hardware and software describes the techniques used, and possible applications to other process control systems. LES is now in the advanced development stage, with a full implementation planned for late 1985.

  20. Self-Centering Seismic Lateral Force Resisting Systems: High Performance Structures for the City of Tomorrow

    Directory of Open Access Journals (Sweden)

    Nathan Brent Chancellor

    2014-09-01

    Full Text Available Structures designed in accordance with even the most modern buildings codes are expected to sustain damage during a severe earthquake; however; these structures are expected to protect the lives of the occupants. Damage to the structure can require expensive repairs; significant business downtime; and in some cases building demolition. If damage occurs to many structures within a city or region; the regional and national economy may be severely disrupted. To address these shortcomings with current seismic lateral force resisting systems and to work towards more resilient; sustainable cities; a new class of seismic lateral force resisting systems that sustains little or no damage under severe earthquakes has been developed. These new seismic lateral force resisting systems reduce or prevent structural damage to nonreplaceable structural elements by softening the structural response elastically through gap opening mechanisms. To dissipate seismic energy; friction elements or replaceable yielding energy dissipation elements are also included. Post-tensioning is often used as a part of these systems to return the structure to a plumb; upright position (self-center after the earthquake has passed. This paper summarizes the state-of-the art for self-centering seismic lateral force resisting systems and outlines current research challenges for these systems.

  1. Total integrated performance excellence system (TIPES): A true north direction for a clinical trial support center.

    Science.gov (United States)

    Sather, Mike R; Parsons, Sherry; Boardman, Kathy D; Warren, Stuart R; Davis-Karim, Anne; Griffin, Kevin; Betterton, Jane A; Jones, Mark S; Johnson, Stanley H; Vertrees, Julia E; Hickey, Jan H; Salazar, Thelma P; Huang, Grant D

    2018-03-01

    This paper presents the quality journey taken by a Federal organization over more than 20 years. These efforts have resulted in the implementation of a Total Integrated Performance Excellence System (TIPES) that combines key principles and practices of established quality systems. The Center has progressively integrated quality system frameworks including the Malcom Baldrige National Quality Award (MBNQA) Framework and Criteria for Performance Excellence, ISO 9001, and the Organizational Project Management Maturity Model (OPM3), as well as supplemental quality systems of ISO 15378 (packaging for medicinal products) and ISO 21500 (guide to project management) to systematically improve all areas of operations. These frameworks were selected for applicability to Center processes and systems, consistency and reinforcement of complimentary approaches, and international acceptance. External validations include the MBNQA, the highest quality award in the US, continued registration and conformance to ISO standards and guidelines, and multiple VA and state awards. With a focus on a holistic approach to quality involving processes, systems and personnel, this paper presents activities and lessons that were critical to building TIPES and establishing the quality environment for conducting clinical research in support of Veterans and national health care.

  2. Total integrated performance excellence system (TIPES: A true north direction for a clinical trial support center

    Directory of Open Access Journals (Sweden)

    Mike R. Sather

    2018-03-01

    Full Text Available This paper presents the quality journey taken by a Federal organization over more than 20 years. These efforts have resulted in the implementation of a Total Integrated Performance Excellence System (TIPES that combines key principles and practices of established quality systems. The Center has progressively integrated quality system frameworks including the Malcom Baldrige National Quality Award (MBNQA Framework and Criteria for Performance Excellence, ISO 9001, and the Organizational Project Management Maturity Model (OPM3, as well as supplemental quality systems of ISO 15378 (packaging for medicinal products and ISO 21500 (guide to project management to systematically improve all areas of operations. These frameworks were selected for applicability to Center processes and systems, consistency and reinforcement of complimentary approaches, and international acceptance. External validations include the MBNQA, the highest quality award in the US, continued registration and conformance to ISO standards and guidelines, and multiple VA and state awards. With a focus on a holistic approach to quality involving processes, systems and personnel, this paper presents activities and lessons that were critical to building TIPES and establishing the quality environment for conducting clinical research in support of Veterans and national health care.

  3. Performance Measurement and Target-Setting in California's Safety Net Health Systems.

    Science.gov (United States)

    Hemmat, Shirin; Schillinger, Dean; Lyles, Courtney; Ackerman, Sara; Gourley, Gato; Vittinghoff, Eric; Handley, Margaret; Sarkar, Urmimala

    Health policies encourage implementing quality measurement with performance targets. The 2010-2015 California Medicaid waiver mandated quality measurement and reporting. In 2013, California safety net hospitals participating in the waiver set a voluntary performance target (the 90th percentile for Medicare preferred provider organization plans) for mammography screening and cholesterol control in diabetes. They did not reach the target, and the difference-in-differences analysis suggested that there was no difference for mammography ( P = .39) and low-density lipoprotein control ( P = .11) performance compared to measures for which no statewide quality improvement initiative existed. California's Medicaid waiver was associated with improved performance on a number of metrics, but this performance was not attributable to target setting on specific health conditions. Performance may have improved because of secular trends or systems improvements related to waiver funding. Relying on condition-specific targets to measure performance may underestimate improvements and disadvantage certain health systems. Achieving ambitious targets likely requires sustained fiscal, management, and workforce investments.

  4. Telemedicine spirometry training and quality assurance program in primary care centers of a public health system.

    Science.gov (United States)

    Marina Malanda, Nuria; López de Santa María, Elena; Gutiérrez, Asunción; Bayón, Juan Carlos; Garcia, Larraitz; Gáldiz, Juan B

    2014-04-01

    Forced spirometry is essential for diagnosing respiratory diseases and is widely used across levels of care. However, several studies have shown that spirometry quality in primary care is not ideal, with risks of misdiagnosis. Our objective was to assess the feasibility and performance of a telemedicine-based training and quality assurance program for forced spirometry in primary care. The two phases included (1) a 9-month pilot study involving 15 centers, in which spirometry tests were assessed by the Basque Office for Health Technology Assessment, and (2) the introduction of the program to all centers in the Public Basque Health Service. Technicians first received 4 h of training, and, subsequently, they sent all tests to the reference laboratory using the program. Quality assessment was performed in accordance with clinical guidelines (A and B, good; C-F, poor). In the first phase, 1,894 spirometry tests were assessed, showing an improvement in quality: acceptable quality tests increased from 57% at the beginning to 78% after 6 months and 83% after 9 months (passessed after the inclusion of 36 additional centers, maintaining the positive trend (61%, 87%, and 84% at the same time points; pquality of spirometry tests improved in all centers. (2) The program provides a tool for transferring data that allows monitoring of its quality and training of technicians who perform the tests. (3) This approach is useful for improving spirometry quality in the routine practice of a public health system.

  5. Characterizing complexity in socio-technical systems: a case study of a SAMU Medical Regulation Center.

    Science.gov (United States)

    Righi, Angela Weber; Wachs, Priscila; Saurin, Tarcísio Abreu

    2012-01-01

    Complexity theory has been adopted by a number of studies as a benchmark to investigate the performance of socio-technical systems, especially those that are characterized by relevant cognitive work. However, there is little guidance on how to assess, systematically, the extent to which a system is complex. The main objective of this study is to carry out a systematic analysis of a SAMU (Mobile Emergency Medical Service) Medical Regulation Center in Brazil, based on the core characteristics of complex systems presented by previous studies. The assessment was based on direct observations and nine interviews: three of them with regulator of emergencies medical doctor, three with radio operators and three with telephone attendants. The results indicated that, to a great extent, the core characteristics of complexity are magnified) due to basic shortcomings in the design of the work system. Thus, some recommendations are put forward with a view to reducing unnecessary complexity that hinders the performance of the socio-technical system.

  6. Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy

    Directory of Open Access Journals (Sweden)

    Han-Chung Wu

    2010-01-01

    Full Text Available Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy.

  7. Therapeutic Innovations for Targeting Childhood Neuroblastoma: Implications of the Neurokinin-1 Receptor System.

    Science.gov (United States)

    Berger, Michael; VON Schweinitz, Dietrich

    2017-11-01

    Neuroblastoma is the most common solid extracranial malignant tumor in children. Despite recent advances in the treatment of this heterogenous tumor with surgery and chemotherapy, the prognosis in advanced stages remains poor. Interestingly, neuroblastoma is one of the few solid tumors, to date, in which an effect for targeted immunotherapy has been proven in controlled clinical trials, giving hope for further advances in the treatment of this and other tumors by targeted therapy. A large array of novel therapeutic options for targeted therapy of neuroblastoma is on the horizon. To this repεrtoirε, the neurokinin-1 receptor (NK1R) system was recently added. The present article explores the most recent developments in targeting neuroblastoma cells via the NK1R and how this new knowledge could be helpful to create new anticancer therapies agains neuroblastoma and other cancers. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  8. Assessment team report on flight-critical systems research at NASA Langley Research Center

    Science.gov (United States)

    Siewiorek, Daniel P. (Compiler); Dunham, Janet R. (Compiler)

    1989-01-01

    The quality, coverage, and distribution of effort of the flight-critical systems research program at NASA Langley Research Center was assessed. Within the scope of the Assessment Team's review, the research program was found to be very sound. All tasks under the current research program were at least partially addressing the industry needs. General recommendations made were to expand the program resources to provide additional coverage of high priority industry needs, including operations and maintenance, and to focus the program on an actual hardware and software system that is under development.

  9. Direct numerical control of machine tools in a nuclear research center by the CAMAC system

    International Nuclear Information System (INIS)

    Zwoll, K.; Mueller, K.D.; Becks, B.; Erven, W.; Sauer, M.

    1977-01-01

    The production of mechanical parts in research centers can be improved by connecting several numerically controlled machine tools to a central process computer via a data link. The CAMAC Serial Highway with its expandable structure yields an economic and flexible system for this purpose. The CAMAC System also facilitates the development of modular components controlling the machine tools itself. A CAMAC installation controlling three different machine tools connected to a central computer (PDP11) via the CAMAC Serial Highway is described. Besides this application, part of the CAMAC hardware and software can also be used for a great variety of scientific experiments

  10. Fiber optic transmission system delivered to Fusion Research Center of Japan Atomic Energy Research Institute

    International Nuclear Information System (INIS)

    Hayashida, Mutsuo; Hiramoto, Kiyoshi; Yamazaki, Kunihiro

    1983-01-01

    In general there are many electromagnetically induced noises in the premises of factories, power plants and substations. Under such electrically bad environments, for the computer data transmission that needs high speed processing and high reliability, the optical fiber cable is superion to the coaxial cable or the flat-type cable in aspects of the inductionlessness and a wide bandwidth. Showa Electric Wire and Cable Co., Ltd. has delivered and installed a computer data transmission system consisting of optical modems and optical fiber cables for connecting every experiment building in the premises of Fusion Research Center of Japan Atomic Energy Research Institute. This paper describes the outline of this system. (author)

  11. A reliability centered maintenance model applied to the auxiliary feedwater system of a nuclear power plant

    International Nuclear Information System (INIS)

    Araujo, Jefferson Borges

    1998-01-01

    The main objective of maintenance in a nuclear power plant is to assure that structures, systems and components will perform their design functions with reliability and availability in order to obtain a safety and economic electric power generation. Reliability Centered Maintenance (RCM) is a method of systematic review to develop or optimize Preventive Maintenance Programs. This study presents the objectives, concepts, organization and methods used in the development of RCM application to nuclear power plants. Some examples of this application are included, considering the Auxiliary Feedwater System of a generic two loops PWR nuclear power plant of Westinghouse design. (author)

  12. Storage Information Management System (SIMS) Spaceflight Hardware Warehousing at Goddard Space Flight Center

    Science.gov (United States)

    Kubicko, Richard M.; Bingham, Lindy

    1995-01-01

    Goddard Space Flight Center (GSFC) on site and leased warehouses contain thousands of items of ground support equipment (GSE) and flight hardware including spacecraft, scaffolding, computer racks, stands, holding fixtures, test equipment, spares, etc. The control of these warehouses, and the management, accountability, and control of the items within them, is accomplished by the Logistics Management Division. To facilitate this management and tracking effort, the Logistics and Transportation Management Branch, is developing a system to provide warehouse personnel, property owners, and managers with storage and inventory information. This paper will describe that PC-based system and address how it will improve GSFC warehouse and storage management.

  13. Selection of melter systems for the DOE/Industrial Center for Waste Vitrification Research

    International Nuclear Information System (INIS)

    Bickford, D.F.

    1993-01-01

    The EPA has designated vitrification as the best developed available technology for immobilization of High-Level Nuclear Waste. In a recent federal facilities compliance agreement between the EPA, the State of Washington, and the DOE, the DOE agreed to vitrify all of the Low Level Radioactive Waste resulting from processing of High Level Radioactive Waste stored at the Hanford Site. This is expected to result in the requirement of 100 ton per day Low Level Radioactive Waste melters. Thus, there is increased need for the rapid adaptation of commercial melter equipment to DOE's needs. DOE has needed a facility where commercial pilot scale equipment could be operated on surrogate (non-radioactive) simulations of typical DOE waste streams. The DOE/Industry Center for Vitrification Research (Center) was established in 1992 at the Clemson University Department of Environmental Systems Engineering, Clemson, SC, to address that need. This report discusses some of the characteristics of the melter types selected for installation of the Center. An overall objective of the Center has been to provide the broadest possible treatment capability with the minimum number of melter units. Thus, units have been sought which have broad potential application, and which had construction characteristics which would allow their adaptation to various waste compositions, and various operating conditions, including extreme variations in throughput, and widely differing radiological control requirements. The report discusses waste types suitable for vitrification; technical requirements for the application of vitrification to low level mixed wastes; available melters and systems; and selection of melter systems. An annotated bibliography is included

  14. Selection of melter systems for the DOE/Industrial Center for Waste Vitrification Research

    Energy Technology Data Exchange (ETDEWEB)

    Bickford, D.F.

    1993-12-31

    The EPA has designated vitrification as the best developed available technology for immobilization of High-Level Nuclear Waste. In a recent federal facilities compliance agreement between the EPA, the State of Washington, and the DOE, the DOE agreed to vitrify all of the Low Level Radioactive Waste resulting from processing of High Level Radioactive Waste stored at the Hanford Site. This is expected to result in the requirement of 100 ton per day Low Level Radioactive Waste melters. Thus, there is increased need for the rapid adaptation of commercial melter equipment to DOE`s needs. DOE has needed a facility where commercial pilot scale equipment could be operated on surrogate (non-radioactive) simulations of typical DOE waste streams. The DOE/Industry Center for Vitrification Research (Center) was established in 1992 at the Clemson University Department of Environmental Systems Engineering, Clemson, SC, to address that need. This report discusses some of the characteristics of the melter types selected for installation of the Center. An overall objective of the Center has been to provide the broadest possible treatment capability with the minimum number of melter units. Thus, units have been sought which have broad potential application, and which had construction characteristics which would allow their adaptation to various waste compositions, and various operating conditions, including extreme variations in throughput, and widely differing radiological control requirements. The report discusses waste types suitable for vitrification; technical requirements for the application of vitrification to low level mixed wastes; available melters and systems; and selection of melter systems. An annotated bibliography is included.

  15. Development of a nickel plated aluminum krypton-81m target system.

    Science.gov (United States)

    Alrumayan, F; Okarvi, S M; Nagatsu, K; Yanbawi, S; Aljammaz, I

    2017-03-01

    A fully automated system was developed to produce rubidium-81 ( 81 Rb), based on the nat Kr (p, n) 81 Rb reaction. The energy incident on the target was 26MeV. Only 6MeV was stopped inside the gas and the remainder was stopped by a specially designed flange. The target body was characterized by its conical shape and its inner walls were chemically plated with 100±10µm of nickel (Ni). Ni is advantageous as a fairly good conductor of heat whose surface can resist solutions. Additionally, the Ni plated target allowed potassium chloride to dissolve 81 Rb, with no further effect on the target body. The system produced 81 Rb with a production yield of approximately 4.5mCi/µAh, which is close to the calculated expected yield of 5.3mCi/µAh. The system is able to deliver reliable and reproducible radioactivity for patients and can be operated up to 1500µAh before preventive maintenance is due. Key steps in designing the 81 Rb target for selected energy ranges are reported here. Copyright © 2016. Published by Elsevier Ltd.

  16. An integrated CRISPR Bombyx mori genome editing system with improved efficiency and expanded target sites.

    Science.gov (United States)

    Ma, Sanyuan; Liu, Yue; Liu, Yuanyuan; Chang, Jiasong; Zhang, Tong; Wang, Xiaogang; Shi, Run; Lu, Wei; Xia, Xiaojuan; Zhao, Ping; Xia, Qingyou

    2017-04-01

    Genome editing enabled unprecedented new opportunities for targeted genomic engineering of a wide variety of organisms ranging from microbes, plants, animals and even human embryos. The serial establishing and rapid applications of genome editing tools significantly accelerated Bombyx mori (B. mori) research during the past years. However, the only CRISPR system in B. mori was the commonly used SpCas9, which only recognize target sites containing NGG PAM sequence. In the present study, we first improve the efficiency of our previous established SpCas9 system by 3.5 folds. The improved high efficiency was also observed at several loci in both BmNs cells and B. mori embryos. Then to expand the target sites, we showed that two newly discovered CRISPR system, SaCas9 and AsCpf1, could also induce highly efficient site-specific genome editing in BmNs cells, and constructed an integrated CRISPR system. Genome-wide analysis of targetable sites was further conducted and showed that the integrated system cover 69,144,399 sites in B. mori genome, and one site could be found in every 6.5 bp. The efficiency and resolution of this CRISPR platform will probably accelerate both fundamental researches and applicable studies in B. mori, and perhaps other insects. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. The Effusive-Flow Properties of Target/Vapor-Transport Systems for Radioactive Ion Beam Applications

    CERN Document Server

    Kawai, Yoko; Liu, Yuan

    2005-01-01

    Radioactive atoms produced by the ISOL technique must diffuse from a target, effusively flow to an ion source, be ionized, be extracted, and be accelerated to research energies in a time commensurate with the lifetime of the species of interest. We have developed a fast valve system (closing time ~100 us) that can be used to accurately measure the effusion times of chemically active or inactive species through arbitrary geometry and size vapor transport systems with and without target material in the reservoir. The effusive flow times are characteristic of the system and thus serve as figures of merit for assessing the quality of a given vapor transport system as well as for assessing the permeability properties of a given target design. This article presents effusive flow data for noble gases flowing through a target reservoir and ion source system routinely used to generate radioactive species at the HRIBF with and without disks of 6 times and 10 times compressed Reticulated Vitreous Carbon Foam (RVCF) with...

  18. Concurrent Mission and Systems Design at NASA Glenn Research Center: The Origins of the COMPASS Team

    Science.gov (United States)

    McGuire, Melissa L.; Oleson, Steven R.; Sarver-Verhey, Timothy R.

    2012-01-01

    Established at the NASA Glenn Research Center (GRC) in 2006 to meet the need for rapid mission analysis and multi-disciplinary systems design for in-space and human missions, the Collaborative Modeling for Parametric Assessment of Space Systems (COMPASS) team is a multidisciplinary, concurrent engineering group whose primary purpose is to perform integrated systems analysis, but it is also capable of designing any system that involves one or more of the disciplines present in the team. The authors were involved in the development of the COMPASS team and its design process, and are continuously making refinements and enhancements. The team was unofficially started in the early 2000s as part of the distributed team known as Team JIMO (Jupiter Icy Moons Orbiter) in support of the multi-center collaborative JIMO spacecraft design during Project Prometheus. This paper documents the origins of a concurrent mission and systems design team at GRC and how it evolved into the COMPASS team, including defining the process, gathering the team and tools, building the facility, and performing studies.

  19. Technological drivers in data centers and telecom systems: Multiscale thermal, electrical, and energy management

    International Nuclear Information System (INIS)

    Garimella, Suresh V.; Persoons, Tim; Weibel, Justin; Yeh, Lian-Tuu

    2013-01-01

    Highlights: ► Thermal management approaches reviewed against energy usage of IT industry. ► Challenges of energy efficiency in large-scale electronic systems highlighted. ► Underlying drivers for progress at the business and technology levels identified. ► Thermal, electrical and energy management challenges discussed as drivers. ► Views of IT system operators, manufacturers and integrators represented. - Abstract: We identify technological drivers for tomorrow’s data centers and telecommunications systems, including thermal, electrical and energy management challenges, based on discussions at the 2nd Workshop on Thermal Management in Telecommunication Systems and Data Centers in Santa Clara, California, on April 25–26, 2012. The relevance of thermal management in electronic systems is reviewed against the background of the energy usage of the information technology (IT) industry, encompassing perspectives of different sectors of the industry. The underlying drivers for progress at the business and technology levels are identified. The technological challenges are reviewed in two main categories – immediate needs and future needs. Enabling cooling techniques that are currently under development are also discussed

  20. Design of an advanced human-centered supervisory system for a nuclear fuel reprocessing system

    International Nuclear Information System (INIS)

    Riera, B.; Lambert, M.; Martel, G.

    1999-01-01

    In the field of highly automated processes, our research concerns supervisory system design adapted to supervisory and default diagnosis by human operators. The interpretation of decisional human behaviour models shows that the tasks of human operators require different information, which has repercussions on the supervisory system design. We propose an advanced human-centred supervisory system (AHCSS) which is more adapted to human-beings, because it integrates new representation of the production system,(such as functional and behavioural aspects) with the use of advanced algorithms of detection and location. Based on an approach using these new concepts, and AHCSS was created for a nuclear fuel reprocessing system. (authors)

  1. Changing the batch system in a Tier 1 computing center: why and how

    Science.gov (United States)

    Chierici, Andrea; Dal Pra, Stefano

    2014-06-01

    At the Italian Tierl Center at CNAF we are evaluating the possibility to change the current production batch system. This activity is motivated mainly because we are looking for a more flexible licensing model as well as to avoid vendor lock-in. We performed a technology tracking exercise and among many possible solutions we chose to evaluate Grid Engine as an alternative because its adoption is increasing in the HEPiX community and because it's supported by the EMI middleware that we currently use on our computing farm. Another INFN site evaluated Slurm and we will compare our results in order to understand pros and cons of the two solutions. We will present the results of our evaluation of Grid Engine, in order to understand if it can fit the requirements of a Tier 1 center, compared to the solution we adopted long ago. We performed a survey and a critical re-evaluation of our farming infrastructure: many production softwares (accounting and monitoring on top of all) rely on our current solution and changing it required us to write new wrappers and adapt the infrastructure to the new system. We believe the results of this investigation can be very useful to other Tier-ls and Tier-2s centers in a similar situation, where the effort of switching may appear too hard to stand. We will provide guidelines in order to understand how difficult this operation can be and how long the change may take.

  2. LORIS: A web-based data management system for multi-center studies.

    Directory of Open Access Journals (Sweden)

    Samir eDas

    2012-01-01

    Full Text Available LORIS (Longitudinal Online Research and Imaging System is a modular and extensible web-based data management system that integrates all aspects of a multi-center study: from heterogeneous data acquisition (imaging, clinical, behavior, genetics to storage, processing and ultimately dissemination. It provides a secure, user-friendly, and streamlined platform to automate the flow of clinical trials and complex multi-center studies. A subject-centric internal organization allows researchers to capture and subsequently extract all information, longitudinal or cross-sectional, from any subset of the study cohort. Extensive error-checking and quality control procedures, security, data management, data querying and administrative functions provide LORIS with a triple capability (i continuous project coordination and monitoring of data acquisition (ii data storage/cleaning/querying, (iii interface with arbitrary external data processing pipelines. LORIS is a complete solution that has been thoroughly tested through the full life cycle of a multi-center longitudinal project# and is now supporting numerous neurodevelopment and neurodegeneration research projects internationally.

  3. Radiological Protection and Nuclear Engineering Studies in Multi-MW Target Systems

    Science.gov (United States)

    Luis, Raul Fernandes

    Several innovative projects involving nuclear technology have emerged around the world in recent years, for applications such as spallation neutron sources, accelerator-driven systems for the transmutation of nuclear waste and radioactive ion beam (RIB) production. While the available neutron Wuxes from nuclear reactors did not increase substantially in intensity over the past three decades, the intensities of neutron sources produced in spallation targets have increased steadily, and should continue to do so during the 21st century. Innovative projects like ESS, MYRRHA and EURISOL lie at the forefront of the ongoing pursuit for increasingly bright neutron sources; driven by proton beams with energies up to 2 GeV and intensities up to several mA, the construction of their proposed facilities involves complex Nuclear Technology and Radiological Protection design studies executed by multidisciplinary teams of scientists and engineers from diUerent branches of Science. The intense neutron Wuxes foreseen for those facilities can be used in several scientiVc research Velds, such as Nuclear Physics and Astrophysics, Medicine and Materials Science. In this work, the target systems of two facilitites for the production of RIBs using the Isotope Separation On-Line (ISOL) method were studied in detail: ISOLDE, operating at CERN since 1967, and EURISOL, the next-generation ISOL facility to be built in Europe. For the EURISOL multi-MW target station, a detailed study of Radiological Protection was carried out using the Monte Carlo code FLUKA. Simulations were done to assess neutron Wuences, Vssion rates, ambient dose equivalent rates during operation and after shutdown and the production of radioactive nuclei in the targets and surrounding materials. DiUerent materials were discussed for diUerent components of the target system, aiming at improving its neutronics performance while keeping the residual activities resulting from material activation as low as possible. The second

  4. Targeted Mutagenesis in Rice Using TALENs and the CRISPR/Cas9 System.

    Science.gov (United States)

    Endo, Masaki; Nishizawa-Yokoi, Ayako; Toki, Seiichi

    2016-01-01

    Sequence-specific nucleases (SSNs), such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated protein 9 nuclease (Cas9) system, are powerful tools for understanding gene function and for developing novel traits in plants. In plant species for which transformation and regeneration systems using protoplasts are not yet established, direct delivery to nuclei of SSNs either in the form of RNA or protein is difficult. Thus, Agrobacterium-mediated transformation of SSN expression constructs in cultured cells is a practical means of delivering targeted mutagenesis in some plant species including rice. Because targeted mutagenesis occurs stochastically in transgenic cells and SSN-mediated targeted mutagenesis often leads to no selectable phenotype, identification of highly mutated cell lines is a critical step in obtaining regenerated plants with desired mutations.

  5. Systems biology-embedded target validation: improving efficacy in drug discovery.

    Science.gov (United States)

    Vandamme, Drieke; Minke, Benedikt A; Fitzmaurice, William; Kholodenko, Boris N; Kolch, Walter

    2014-01-01

    The pharmaceutical industry is faced with a range of challenges with the ever-escalating costs of drug development and a drying out of drug pipelines. By harnessing advances in -omics technologies and moving away from the standard, reductionist model of drug discovery, there is significant potential to reduce costs and improve efficacy. Embedding systems biology approaches in drug discovery, which seek to investigate underlying molecular mechanisms of potential drug targets in a network context, will reduce attrition rates by earlier target validation and the introduction of novel targets into the currently stagnant market. Systems biology approaches also have the potential to assist in the design of multidrug treatments and repositioning of existing drugs, while stratifying patients to give a greater personalization of medical treatment. © 2013 Wiley Periodicals, Inc.

  6. Mathematical model for adaptive control system of ASEA robot at Kennedy Space Center

    Science.gov (United States)

    Zia, Omar

    1989-01-01

    The dynamic properties and the mathematical model for the adaptive control of the robotic system presently under investigation at Robotic Application and Development Laboratory at Kennedy Space Center are discussed. NASA is currently investigating the use of robotic manipulators for mating and demating of fuel lines to the Space Shuttle Vehicle prior to launch. The Robotic system used as a testbed for this purpose is an ASEA IRB-90 industrial robot with adaptive control capabilities. The system was tested and it's performance with respect to stability was improved by using an analogue force controller. The objective of this research project is to determine the mathematical model of the system operating under force feedback control with varying dynamic internal perturbation in order to provide continuous stable operation under variable load conditions. A series of lumped parameter models are developed. The models include some effects of robot structural dynamics, sensor compliance, and workpiece dynamics.

  7. Diversity and MIMO Performance Evaluation of Common Phase Center Multi Element Antenna Systems

    Directory of Open Access Journals (Sweden)

    V. Papamichael

    2008-06-01

    Full Text Available The diversity and Multiple Input Multiple Output (MIMO performance provided by common phase center multi element antenna (CPCMEA systems is evaluated using two practical methods which make use of the realized active element antenna patterns. These patterns include both the impact of the mutual coupling and the mismatch power loss at antenna ports. As a case study, two and four printed Inverted F Antenna (IFA systems are evaluated by means of Effective Diversity Gain (EDG and Capacity (C. EDG is measured in terms of the signal-to-noise ratio (SNR enhancement at a specific outage probability and in terms of the SNR reduction for achieving a desired average bit error rate (BER. The concept of receive antenna selection in MIMO systems is also investigated and the simulation results show a 43% improvement in the 1% outage C of a reconfigurable 2x2 MIMO system over a fixed 2x2 one.

  8. The Johnson Space Center management information systems: User's guide to JSCMIS

    Science.gov (United States)

    Bishop, Peter C.; Erickson, Lloyd

    1990-01-01

    The Johnson Space Center Management Information System (JSCMIS) is an interface to computer data bases at the NASA Johnson Space Center which allows an authorized user to browse and retrieve information from a variety of sources with minimum effort. The User's Guide to JSCMIS is the supplement to the JSCMIS Research Report which details the objectives, the architecture, and implementation of the interface. It is a tutorial on how to use the interface and a reference for details about it. The guide is structured like an extended JSCMIS session, describing all of the interface features and how to use them. It also contains an appendix with each of the standard FORMATs currently included in the interface. Users may review them to decide which FORMAT most suits their needs.

  9. Modelling the impacts of challenging 2050 European climate mitigation targets on Ireland’s energy system

    International Nuclear Information System (INIS)

    Chiodi, Alessandro; Gargiulo, Maurizio; Rogan, Fionn; Deane, J.P.; Lavigne, Denis; Rout, Ullash K.; Ó Gallachóir, Brian P.

    2013-01-01

    The Copenhagen Accord established political consensus on the 2 °C limit (in global temperature increase) and for deep cuts in greenhouse gas (GHG) emissions levels to achieve this goal. The European Union has set ambitious GHG targets for the year 2050 (80–95% below 1990 levels), with each Member State developing strategies to contribute to these targets. This paper focuses on mitigation targets for one Member State, Ireland, an interesting case study due to the growth in GHG emissions (24% increase between 1990 and 2005) and the high share of emissions from agriculture (30% of total GHG emissions). We use the Irish TIMES energy systems modelling tool to build a number of scenarios delivering an 80% emissions reduction target by 2050, including accounting for the limited options for agriculture GHG abatement by increasing the emissions reduction target for the energy system. We then compare the scenario results in terms of changes in energy technology, the role of energy efficiency and renewable energy. We also quantify the economic impacts of the mitigation scenarios in terms of marginal CO 2 abatement costs and energy system costs. The paper also sheds light on the impacts of short term targets and policies on long term mitigation pathways. - Highlights: ► We developed a techno-economic energy model of Ireland to the year 2050. ► Reductions between 80% and 95% of GHG emissions can be technically achieved. ► A 50% emissions cut in agriculture requires a 95% reductions from the energy system. ► Extending current policies implies greater electrification and efficiency measures. ► The additional cost to achieve mitigation remain less than 2% of GDP levels in 2050.

  10. Reimbursement of targeted cancer therapies within three different European health care systems

    NARCIS (Netherlands)

    Mihajlovic, Jovan; Dolk, C.; Postma, Maarten

    2014-01-01

    Objectives: To identify differences in the recommendations for targeted cancer therapies (TCT) in three distinctive European health care systems: Serbian, Scottish and Dutch, and to examine the role of cost effectiveness analyses (CEA) in such recommendations. Methods: A list of currently approved

  11. [Study on liver targeted drug delivery system of the effective anticancer component from Bolbstemma paniculatum].

    Science.gov (United States)

    Sun, Yi-Yi; Ll, Tong-Hui; Tang, Chen-Kang; Zhu, Zi-Ping; Chi, Qun; Hou, Shi-Xiang

    2005-06-01

    To study the liver targeted drug delivery system of TBMS--the effective anticancer component from Bolbstemma paniculatum, and to discuss the system's function of decreasing toxicity. BCA was used as carrier material. The preparation through overall feedback dynamic techniques. The properties of preparation and toxicology were also technology of nanoparticles was optimized studied. Thenanoparticles' targeting in mice vivo was observed with transmission electron microscopy. The function of decreasing toxicity was researched by the XXTX-2000 automatic quantitative analysis management system. D50 was 0.68 microm. Drug-loading rate and entrapment rate were 37.3% and 88.6% respectively. The release in vitro accorded with Weibull equation. The reaching release balance time and the t 1/2 extended 26 times and 19 times respectively comparing with injection. Nanoparticles mainly distributed in liver tissue. Their toxicity to lung and liver was evidently lower than injection. Nanoparticles' LD50 exceeded injection's by 13.5% and their stimulus was much lower than injection. The TBMS can be targeted to liver by liver targeted drug delivery system. At the same time, the problem about the toxicity hindering clinical application could be solved, which lays the foundation for the further studies on TBMS.

  12. 77 FR 30433 - Privacy Act of 1974: Implementation of Exemptions; Automated Targeting System

    Science.gov (United States)

    2012-05-23

    ... Border Protection, Mint Annex, 799 Ninth Street NW., Washington, DC 20229. For privacy issues please... Secretary 6 CFR Part 5 [Docket No. DHS-2012-0020] Privacy Act of 1974: Implementation of Exemptions; Automated Targeting System AGENCY: Privacy Office, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The...

  13. Flood risk and economically optimal safety targets for coastal flood defense systems

    NARCIS (Netherlands)

    Dupuits, E.J.C.; Schweckendiek, T.

    2015-01-01

    A front defense can improve the reliability of a rear defense in a coastal flood defense system. The influence of this interdependency on the accompanying economically optimal safety targets of both front and rear defense is investigated. The results preliminary suggest that the optimal safety level

  14. Simulation of beam pointing stability on targeting plane of high power excimer laser system

    International Nuclear Information System (INIS)

    Wang Dahui; Zhao Xueqing; Zhang Yongsheng; Zheng Guoxin; Hu Yun; Zhao Jun

    2011-01-01

    Based on characteristics of image-relaying structure in high power excimer MOPA laser system, simulation and analysis software of targeting beam's barycenter stability was designed by using LABVIEW and MATLAB. Simulation was made to measured results of every optical component in laboratory environment. Simulation and validation of budget values for optical components was and optimization of error budget of system was accomplished via post-allocation for several times. It is shown that targeting beam's barycenter stability in the condition of current laboratory environment can't satisfy needs and index of high demand optical components can be allotted to 1.7 μrad when index of low demand optical components have some stability margin. These results can provide a guide to construction of system and design and machining of optical components and optimization of system. Optical components of laboratory on work can satisfy optimized distributed index, which reduce the demand of structure to some extent. (authors)

  15. Design of a control system for HIRFL-CSRe internal target facility in Lanzhou

    International Nuclear Information System (INIS)

    Wang Yanyu; Liu Wufeng; Shao Caojie; Lin Feiyu; Zhang Jianchuan; Xiao Wenjun

    2010-01-01

    It is described in this paper the design of the control system for HIRFL-CSRe internal target facility, in which there are many different kinds of units need to be monitored and controlled. The control system is composed of several subsystems which are designed to control the gas-jet temperature, chamber vacuum, valves and molecular pumps. A human-computer interaction interface is also realized to do the data acquisition, data processing and display. The whole system has been working stably and safely, it fully meets the requirements of physical experiments in the internal target facility. In January of 2010, the first physics experiment of the radioactive electron capture was finished successfully with the aids of this control system. (authors)

  16. [Advances of tumor targeting peptides drug delivery system with pH-sensitive activities].

    Science.gov (United States)

    Ma, Yin-yun; Li, Li; Huang, Hai-feng; Gou, San-hu; Ni, Jing-man

    2016-05-01

    The pH-sensitive peptides drug delivery systems, which target to acidic extracellular environment of tumor tissue, have many advantages in drug delivery. They exhibit a high specificity to tumor and low cytotoxicity, which significantly increase the efficacy of traditional anti-cancer drugs. In recent years the systems have received a great attention. The pH-sensitive peptides drug delivery systems can be divided into five types according to the difference in pH-responsive mechanism,type of peptides and carrier materials. This paper summarizes the recent progresses in the field with a focus on the five types of pH-sensitive peptides in drug delivery systems. This may provide a guideline to design and application of tumor targeting drugs.

  17. Current state and future direction of computer systems at NASA Langley Research Center

    Science.gov (United States)

    Rogers, James L. (Editor); Tucker, Jerry H. (Editor)

    1992-01-01

    Computer systems have advanced at a rate unmatched by any other area of technology. As performance has dramatically increased there has been an equally dramatic reduction in cost. This constant cost performance improvement has precipitated the pervasiveness of computer systems into virtually all areas of technology. This improvement is due primarily to advances in microelectronics. Most people are now convinced that the new generation of supercomputers will be built using a large number (possibly thousands) of high performance microprocessors. Although the spectacular improvements in computer systems have come about because of these hardware advances, there has also been a steady improvement in software techniques. In an effort to understand how these hardware and software advances will effect research at NASA LaRC, the Computer Systems Technical Committee drafted this white paper to examine the current state and possible future directions of computer systems at the Center. This paper discusses selected important areas of computer systems including real-time systems, embedded systems, high performance computing, distributed computing networks, data acquisition systems, artificial intelligence, and visualization.

  18. Profitability indicators of milk production cost center in intensive systems of production

    Directory of Open Access Journals (Sweden)

    Glauber dos Santos

    2012-01-01

    Full Text Available The objective was to estimate some profitability indicators of dairy cost center farms with a high volume of daily production in feedlot. The Intended was also to identify the components that had the greatest influence on the operational cost. We used data from three milk systems production, with the origin of the purebred Holsteins. It was considered as a milk cost center production all expenses related in lactating and dry cows. The methodology used total cost and operating cost in profitability analysis. A production system, by presenting gross margin, net positive result, was able to produce short, medium and long term. Another production system had a positive gross margin and net, with conditions to survive in the short and medium term. Finally, the third system of production has shown a negative gross margin presenting decapitalizing and entering into debt, as revenues were not enough to pay operating expenses even effective. The component items of the effective operational cost that exercised higher “impact” cost and income from milk were, in decreasing order, the feeding, labor, miscellaneous expenses, sanitation, energy, milking, reproduction, equipment rental, BST and taxes.

  19. Johnson Space Center's Solar and Wind-Based Renewable Energy System

    Science.gov (United States)

    Vasquez, A.; Ewert, M.; Rowlands, J.; Post, K.

    2009-01-01

    The NASA Johnson Space Center (JSC) in Houston, Texas has a Sustainability Partnership team that seeks ways for earth-based sustainability practices to also benefit space exploration research. A renewable energy gathering system was installed in 2007 at the JSC Child Care Center (CCC) which also offers a potential test bed for space exploration power generation and remote monitoring and control concepts. The system comprises: 1) several different types of photovoltaic panels (29 kW), 2) two wind-turbines (3.6 kW total), and 3) one roof-mounted solar thermal water heater and tank. A tie to the JSC local electrical grid was provided to accommodate excess power. The total first year electrical energy production was 53 megawatt-hours. A web-based real-time metering system collects and reports system performance and weather data. Improvements in areas of the CCC that were detected during subsequent energy analyses and some concepts for future efforts are also presented.

  20. Health at the center of health systems reform: how philosophy can inform policy.

    Science.gov (United States)

    Sturmberg, Joachim P; Martin, Carmel M; Moes, Mark M

    2010-01-01

    Contemporary views hold that health and disease can be defined as objective states and thus should determine the design and delivery of health services. Yet health concepts are elusive and contestable. Health is neither an individual construction, a reflection of societal expectations, nor only the absence of pathologies. Based on philosophical and sociological theory, empirical evidence, and clinical experience, we argue that health has simultaneously objective and subjective features that converge into a dynamic complex-adaptive health model. Health (or its dysfunction, illness) is a dynamic state representing complex patterns of adaptation to body, mind, social, and environmental challenges, resulting in bodily homeostasis and personal internal coherence. The "balance of health" model-emergent, self-organizing, dynamic, and adaptive-underpins the very essence of medicine. This model should be the foundation for health systems design and also should inform therapeutic approaches, policy decision-making, and the development of emerging health service models. A complex adaptive health system focused on achieving the best possible "personal" health outcomes must provide the broad policy frameworks and resources required to implement people-centered health care. People-centered health systems are emergent in nature, resulting in locally different but mutually compatible solutions across the whole health system.

  1. Penalty Dynamic Programming Algorithm for Dim Targets Detection in Sensor Systems

    Directory of Open Access Journals (Sweden)

    Yunfei Guo

    2012-04-01

    Full Text Available In order to detect and track multiple maneuvering dim targets in sensor systems, an improved dynamic programming track-before-detect algorithm (DP-TBD called penalty DP-TBD (PDP-TBD is proposed. The performances of tracking techniques are used as a feedback to the detection part. The feedback is constructed by a penalty term in the merit function, and the penalty term is a function of the possible target state estimation, which can be obtained by the tracking methods. With this feedback, the algorithm combines traditional tracking techniques with DP-TBD and it can be applied to simultaneously detect and track maneuvering dim targets. Meanwhile, a reasonable constraint that a sensor measurement can originate from one target or clutter is proposed to minimize track separation. Thus, the algorithm can be used in the multi-target situation with unknown target numbers. The efficiency and advantages of PDP-TBD compared with two existing methods are demonstrated by several simulations.

  2. Targeted gene deletion of miRNAs in mice by TALEN system.

    Science.gov (United States)

    Takada, Shuji; Sato, Tempei; Ito, Yoshiaki; Yamashita, Satoshi; Kato, Tomoko; Kawasumi, Miyuri; Kanai-Azuma, Masami; Igarashi, Arisa; Kato, Tomomi; Tamano, Moe; Asahara, Hiroshi

    2013-01-01

    Mice are among the most valuable model animal species with an enormous amount of heritage in genetic modification studies. However, targeting genes in mice is sometimes difficult, especially for small genes, such as microRNAs (miRNAs) and targeting genes in repeat sequences. Here we optimized the application of TALEN system for mice and successfully obtained gene targeting technique in mice for intergenic region and series of microRNAs. Microinjection of synthesized RNA of TALEN targeting each gene in one cell stage of embryo was carried out and injected oocytes were transferred into pseudopregnant ICR female mice, producing a high success rate of the targeted deletion of miRNA genes. In our condition, TALEN RNA without poly(A) tail worked better than that of with poly(A) tail. This mutated allele in miRNA was transmitted to the next generation, suggesting the successful germ line transmission of this targeting method. Consistent with our notion of miRNAs maturation mechanism, in homozygous mutant mice of miR-10a, the non- mutated strand of miRNAs expression was completely diminished. This method will lead us to expand and accelerate our genetic research using mice in a high throughput way.

  3. Targeted gene deletion of miRNAs in mice by TALEN system.

    Directory of Open Access Journals (Sweden)

    Shuji Takada

    Full Text Available Mice are among the most valuable model animal species with an enormous amount of heritage in genetic modification studies. However, targeting genes in mice is sometimes difficult, especially for small genes, such as microRNAs (miRNAs and targeting genes in repeat sequences. Here we optimized the application of TALEN system for mice and successfully obtained gene targeting technique in mice for intergenic region and series of microRNAs. Microinjection of synthesized RNA of TALEN targeting each gene in one cell stage of embryo was carried out and injected oocytes were transferred into pseudopregnant ICR female mice, producing a high success rate of the targeted deletion of miRNA genes. In our condition, TALEN RNA without poly(A tail worked better than that of with poly(A tail. This mutated allele in miRNA was transmitted to the next generation, suggesting the successful germ line transmission of this targeting method. Consistent with our notion of miRNAs maturation mechanism, in homozygous mutant mice of miR-10a, the non- mutated strand of miRNAs expression was completely diminished. This method will lead us to expand and accelerate our genetic research using mice in a high throughput way.

  4. Computed tomography evaluation of rotary systems on the root canal transportation and centering ability

    Energy Technology Data Exchange (ETDEWEB)

    Pagliosa, Andre; Raucci-Neto, Walter; Silva-Souza, Yara Teresinha Correa; Alfredo, Edson, E-mail: ysousa@unaerp.br [Universidade de Ribeirao Preto (UNAERP), SP (Brazil). Fac. de Odontologia; Sousa-Neto, Manoel Damiao; Versiani, Marco Aurelio [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Fac. de Odoentologia

    2015-03-01

    The endodontic preparation of curved and narrow root canals is challenging, with a tendency for the prepared canal to deviate away from its natural axis. The aim of this study was to evaluate, by cone-beam computed tomography, the transportation and centering ability of curved mesiobuccal canals in maxillary molars after biomechanical preparation with different nickel-titanium (NiTi) rotary systems. Forty teeth with angles of curvature ranging from 20° to 40° and radii between 5.0 mm and 10.0 mm were selected and assigned into four groups (n = 10), according to the biomechanical preparative system used: Hero 642 (HR), Liberator (LB), ProTaper (PT), and Twisted File (TF). The specimens were inserted into an acrylic device and scanned with computed tomography prior to, and following, instrumentation at 3, 6 and 9 mm from the root apex. The canal degree of transportation and centering ability were calculated and analyzed using one-way ANOVA and Tukey’s tests (α = 0.05). The results demonstrated no significant difference (p > 0.05) in shaping ability among the rotary systems. The mean canal transportation was: -0.049 ± 0.083 mm (HR); -0.004 ± 0.044 mm (LB); -0.003 ± 0.064 mm (PT); -0.021 ± 0.064 mm (TF). The mean canal centering ability was: -0.093 ± 0.147 mm (HR); -0.001 ± 0.100 mm (LB); -0.002 ± 0.134 mm (PT); -0.033 ± 0.133 mm (TF). Also, there was no significant difference among the root segments (p > 0.05). It was concluded that the Hero 642, Liberator, ProTaper, and Twisted File rotary systems could be safely used in curved canal instrumentation, resulting in satisfactory preservation of the original canal shape. (author)

  5. Computed tomography evaluation of rotary systems on the root canal transportation and centering ability

    Directory of Open Access Journals (Sweden)

    André PAGLIOSA

    2015-01-01

    Full Text Available Abstract : The endodontic preparation of curved and narrow root canals is challenging, with a tendency for the prepared canal to deviate away from its natural axis. The aim of this study was to evaluate, by cone-beam computed tomography, the transportation and centering ability of curved mesiobuccal canals in maxillary molars after biomechanical preparation with different nickel-titanium (NiTi rotary systems. Forty teeth with angles of curvature ranging from 20° to 40° and radii between 5.0 mm and 10.0 mm were selected and assigned into four groups (n = 10, according to the biomechanical preparative system used: Hero 642 (HR, Liberator (LB, ProTaper (PT, and Twisted File (TF. The specimens were inserted into an acrylic device and scanned with computed tomography prior to, and following, instrumentation at 3, 6 and 9 mm from the root apex. The canal degree of transportation and centering ability were calculated and analyzed using one-way ANOVA and Tukey’s tests (α = 0.05. The results demonstrated no significant difference (p > 0.05 in shaping ability among the rotary systems. The mean canal transportation was: -0.049 ± 0.083 mm (HR; -0.004 ± 0.044 mm (LB; -0.003 ± 0.064 mm (PT; -0.021 ± 0.064 mm (TF. The mean canal centering ability was: -0.093 ± 0.147 mm (HR; -0.001 ± 0.100 mm (LB; -0.002 ± 0.134 mm (PT; -0.033 ± 0.133 mm (TF. Also, there was no significant difference among the root segments (p > 0.05. It was concluded that the Hero 642, Liberator, ProTaper, and Twisted File rotary systems could be safely used in curved canal instrumentation, resulting in satisfactory preservation of the original canal shape.

  6. Computed tomography evaluation of rotary systems on the root canal transportation and centering ability

    International Nuclear Information System (INIS)

    Pagliosa, Andre; Raucci-Neto, Walter; Silva-Souza, Yara Teresinha Correa; Alfredo, Edson; Sousa-Neto, Manoel Damiao; Versiani, Marco Aurelio

    2015-01-01

    The endodontic preparation of curved and narrow root canals is challenging, with a tendency for the prepared canal to deviate away from its natural axis. The aim of this study was to evaluate, by cone-beam computed tomography, the transportation and centering ability of curved mesiobuccal canals in maxillary molars after biomechanical preparation with different nickel-titanium (NiTi) rotary systems. Forty teeth with angles of curvature ranging from 20° to 40° and radii between 5.0 mm and 10.0 mm were selected and assigned into four groups (n = 10), according to the biomechanical preparative system used: Hero 642 (HR), Liberator (LB), ProTaper (PT), and Twisted File (TF). The specimens were inserted into an acrylic device and scanned with computed tomography prior to, and following, instrumentation at 3, 6 and 9 mm from the root apex. The canal degree of transportation and centering ability were calculated and analyzed using one-way ANOVA and Tukey’s tests (α = 0.05). The results demonstrated no significant difference (p > 0.05) in shaping ability among the rotary systems. The mean canal transportation was: -0.049 ± 0.083 mm (HR); -0.004 ± 0.044 mm (LB); -0.003 ± 0.064 mm (PT); -0.021 ± 0.064 mm (TF). The mean canal centering ability was: -0.093 ± 0.147 mm (HR); -0.001 ± 0.100 mm (LB); -0.002 ± 0.134 mm (PT); -0.033 ± 0.133 mm (TF). Also, there was no significant difference among the root segments (p > 0.05). It was concluded that the Hero 642, Liberator, ProTaper, and Twisted File rotary systems could be safely used in curved canal instrumentation, resulting in satisfactory preservation of the original canal shape. (author)

  7. A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer

    OpenAIRE

    Neveu, Bertrand; Jain, Pallavi; T?tu, Bernard; Wu, Lily; Fradet, Yves; Pouliot, Fr?d?ric

    2015-01-01

    Targeting specifically primary prostate cancer (PCa) cells for immune therapy, gene therapy or molecular imaging is of high importance. The PCA3 long non-coding RNA is a unique PCa biomarker and oncogene that has been widely studied. This gene has been mainly exploited as an accurate diagnostic urine biomarker for PCa detection. In this study, the PCA3 promoter was introduced into a new transcriptional amplification system named the 3-Step Transcriptional Amplification System (PCA3-3STA) and ...

  8. Enhancing Targeted Genomic DNA Editing in Chicken Cells Using the CRISPR/Cas9 System

    Science.gov (United States)

    Wang, Ling; Yang, Likai; Guo, Yijie; Du, Weili; Yin, Yajun; Zhang, Tao; Lu, Hongzhao

    2017-01-01

    The CRISPR/Cas9 system has enabled highly efficient genome targeted editing for various organisms. However, few studies have focused on CRISPR/Cas9 nuclease-mediated chicken genome editing compared with mammalian genomes. The current study combined CRISPR with yeast Rad52 (yRad52) to enhance targeted genomic DNA editing in chicken DF-1 cells. The efficiency of CRISPR/Cas9 nuclease-induced targeted mutations in the chicken genome was increased to 41.9% via the enrichment of the dual-reporter surrogate system. In addition, the combined effect of CRISPR nuclease and yRad52 dramatically increased the efficiency of the targeted substitution in the myostatin gene using 50-mer oligodeoxynucleotides (ssODN) as the donor DNA, resulting in a 36.7% editing efficiency after puromycin selection. Furthermore, based on the effect of yRad52, the frequency of exogenous gene integration in the chicken genome was more than 3-fold higher than that without yRad52. Collectively, these results suggest that ssODN is an ideal donor DNA for targeted substitution and that CRISPR/Cas9 combined with yRad52 significantly enhances chicken genome editing. These findings could be extensively applied in other organisms. PMID:28068387

  9. Drugs and drug delivery systems targeting amyloid-β in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Morgan Robinson

    2015-07-01

    Full Text Available Alzheimer's disease (AD is a devastating neurodegenerative disorder with no cure and limited treatment solutions that are unable to target any of the suspected causes. Increasing evidence suggests that one of the causes of neurodegeneration is the overproduction of amyloid beta (Aβ and the inability of Aβ peptides to be cleared from the brain, resulting in self-aggregation to form toxic oligomers, fibrils and plaques. One of the potential treatment options is to target Aβ and prevent self-aggregation to allow for a natural clearing of the brain. In this paper, we review the drugs and drug delivery systems that target Aβ in relation to Alzheimer's disease. Many attempts have been made to use anti-Aβ targeting molecules capable of targeting Aβ (with much success in vitro and in vivo animal models, but the major obstacle to this technique is the challenge posed by the blood brain barrier (BBB. This highly selective barrier protects the brain from toxic molecules and pathogens and prevents the delivery of most drugs. Therefore novel Aβ aggregation inhibitor drugs will require well thought-out drug delivery systems to deliver sufficient concentrations to the brain.

  10. Magnetic chitosan nanoparticles as a drug delivery system for targeting photodynamic therapy

    International Nuclear Information System (INIS)

    Sun Yun; Chen Zhilong; Yang Xiaoxia; Huang Peng; Zhou Xinping; Du Xiaoxia

    2009-01-01

    Photodynamic therapy (PDT) has become an increasingly recognized alternative to cancer treatment in clinic. However, PDT therapy agents, namely photosensitizer (PS), are limited in application as a result of prolonged cutaneous photosensitivity, poor water solubility and inadequate selectivity, which are encountered by numerous chemical therapies. Magnetic chitosan nanoparticles provide excellent biocompatibility, biodegradability, non-toxicity and water solubility without compromising their magnetic targeting. Nevertheless, no previous attempt has been reported to develop an in vivo magnetic drug delivery system with chitosan nanoparticles for magnetic resonance imaging (MRI) monitored targeting photodynamic therapy. In this study, magnetic targeting chitosan nanoparticles (MTCNPs) were prepared and tailored as a drug delivery system and imaging agents for PS, designated as PHPP. Results showed that PHPP-MTCNPs could be used in MRI monitored targeting PDT with excellent targeting and imaging ability. Non-toxicity and high photodynamic efficacy on SW480 carcinoma cells both in vitro and in vivo were achieved with this method at the level of 0-100 μM. Notably, localization of nanoparticles in skin and hepatic tissue was significantly less than in tumor tissue, therefore photosensitivity and hepatotoxicity can be attenuated.

  11. Location detection and tracking of moving targets by a 2D IR-UWB radar system.

    Science.gov (United States)

    Nguyen, Van-Han; Pyun, Jae-Young

    2015-03-19

    In indoor environments, the Global Positioning System (GPS) and long-range tracking radar systems are not optimal, because of signal propagation limitations in the indoor environment. In recent years, the use of ultra-wide band (UWB) technology has become a possible solution for object detection, localization and tracking in indoor environments, because of its high range resolution, compact size and low cost. This paper presents improved target detection and tracking techniques for moving objects with impulse-radio UWB (IR-UWB) radar in a short-range indoor area. This is achieved through signal-processing steps, such as clutter reduction, target detection, target localization and tracking. In this paper, we introduce a new combination consisting of our proposed signal-processing procedures. In the clutter-reduction step, a filtering method that uses a Kalman filter (KF) is proposed. Then, in the target detection step, a modification of the conventional CLEAN algorithm which is used to estimate the impulse response from observation region is applied for the advanced elimination of false alarms. Then, the output is fed into the target localization and tracking step, in which the target location and trajectory are determined and tracked by using unscented KF in two-dimensional coordinates. In each step, the proposed methods are compared to conventional methods to demonstrate the differences in performance. The experiments are carried out using actual IR-UWB radar under different scenarios. The results verify that the proposed methods can improve the probability and efficiency of target detection and tracking.

  12. Location Detection and Tracking of Moving Targets by a 2D IR-UWB Radar System

    Directory of Open Access Journals (Sweden)

    Van-Han Nguyen

    2015-03-01

    Full Text Available In indoor environments, the Global Positioning System (GPS and long-range tracking radar systems are not optimal, because of signal propagation limitations in the indoor environment. In recent years, the use of ultra-wide band (UWB technology has become a possible solution for object detection, localization and tracking in indoor environments, because of its high range resolution, compact size and low cost. This paper presents improved target detection and tracking techniques for moving objects with impulse-radio UWB (IR-UWB radar in a short-range indoor area. This is achieved through signal-processing steps, such as clutter reduction, target detection, target localization and tracking. In this paper, we introduce a new combination consisting of our proposed signal-processing procedures. In the clutter-reduction step, a filtering method that uses a Kalman filter (KF is proposed. Then, in the target detection step, a modification of the conventional CLEAN algorithm which is used to estimate the impulse response from observation region is applied for the advanced elimination of false alarms. Then, the output is fed into the target localization and tracking step, in which the target location and trajectory are determined and tracked by using unscented KF in two-dimensional coordinates. In each step, the proposed methods are compared to conventional methods to demonstrate the differences in performance. The experiments are carried out using actual IR-UWB radar under different scenarios. The results verify that the proposed methods can improve the probability and efficiency of target detection and tracking.

  13. The trauma ecosystem: The impact and economics of new trauma centers on a mature statewide trauma system.

    Science.gov (United States)

    Ciesla, David J; Pracht, Etienne E; Leitz, Pablo T; Spain, David A; Staudenmayer, Kristan L; Tepas, Joseph J

    2017-06-01

    Florida serves as a model for the study of trauma system performance. Between 2010 and 2104, 5 new trauma centers were opened alongside 20 existing centers. The purpose of this study was to explore the impact of trauma system expansion on system triage performance and trauma center patients' profiles. A statewide data set was queried for all injury-related discharges from adult acute care hospitals using International Classification of Diseases, Ninth Revision (ICD-9) codes for 2010 and 2014. The data set, inclusion criteria, and definitions of high-risk injury were chosen to match those used by the Florida Department of Health in its trauma registry. Hospitals were classified as existing Level I (E1) or Level II (E2) trauma centers and new E2 (N2) centers. Five N2 centers were established 11.6 to 85.3 miles from existing centers. Field and overall trauma system triage of high-risk patients was less accurate with increased overtriage and no change in undertriage. Annual volume at N2 centers increased but did not change at E1 and E2 centers. In 2014, Patients at E1 and E2 centers were slightly older and less severely injured, while those at N2 centers were substantially younger and more severely injured than in 2010. The injured patient-payer mix changed with a decrease in self-pay and commercial patients and an increase in government-sponsored patients at E1 and E2 centers and an increase in self-pay and commercial patients with a decrease in government-sponsored patients at N2 centers. Designation of new trauma centers in a mature system was associated with a change in established trauma center demographics and economics without an improvement in trauma system triage performance. These findings suggest that the health of an entire trauma system network must be considered in the design and implementation of a regional trauma system. Therapeutic/care management study, level IV; epidemiological, level IV.

  14. Interacting with target tracking algorithms in a gaze-enhanced motion video analysis system

    Science.gov (United States)

    Hild, Jutta; Krüger, Wolfgang; Heinze, Norbert; Peinsipp-Byma, Elisabeth; Beyerer, Jürgen

    2016-05-01

    Motion video analysis is a challenging task, particularly if real-time analysis is required. It is therefore an important issue how to provide suitable assistance for the human operator. Given that the use of customized video analysis systems is more and more established, one supporting measure is to provide system functions which perform subtasks of the analysis. Recent progress in the development of automated image exploitation algorithms allow, e.g., real-time moving target tracking. Another supporting measure is to provide a user interface which strives to reduce the perceptual, cognitive and motor load of the human operator for example by incorporating the operator's visual focus of attention. A gaze-enhanced user interface is able to help here. This work extends prior work on automated target recognition, segmentation, and tracking algorithms as well as about the benefits of a gaze-enhanced user interface for interaction with moving targets. We also propose a prototypical system design aiming to combine both the qualities of the human observer's perception and the automated algorithms in order to improve the overall performance of a real-time video analysis system. In this contribution, we address two novel issues analyzing gaze-based interaction with target tracking algorithms. The first issue extends the gaze-based triggering of a target tracking process, e.g., investigating how to best relaunch in the case of track loss. The second issue addresses the initialization of tracking algorithms without motion segmentation where the operator has to provide the system with the object's image region in order to start the tracking algorithm.

  15. Systems biology approaches and tools for analysis of interactomes and multi-target drugs.

    Science.gov (United States)

    Schrattenholz, André; Groebe, Karlfried; Soskic, Vukic

    2010-01-01

    Systems biology is essentially a proteomic and epigenetic exercise because the relatively condensed information of genomes unfolds on the level of proteins. The flexibility of cellular architectures is not only mediated by a dazzling number of proteinaceous species but moreover by the kinetics of their molecular changes: The time scales of posttranslational modifications range from milliseconds to years. The genetic framework of an organism only provides the blue print of protein embodiments which are constantly shaped by external input. Indeed, posttranslational modifications of proteins represent the scope and velocity of these inputs and fulfil the requirements of integration of external spatiotemporal signal transduction inside an organism. The optimization of biochemical networks for this type of information processing and storage results in chemically extremely fine tuned molecular entities. The huge dynamic range of concentrations, the chemical diversity and the necessity of synchronisation of complex protein expression patterns pose the major challenge of systemic analysis of biological models. One further message is that many of the key reactions in living systems are essentially based on interactions of moderate affinities and moderate selectivities. This principle is responsible for the enormous flexibility and redundancy of cellular circuitries. In complex disorders such as cancer or neurodegenerative diseases, which initially appear to be rooted in relatively subtle dysfunctions of multimodal physiologic pathways, drug discovery programs based on the concept of high affinity/high specificity compounds ("one-target, one-disease"), which has been dominating the pharmaceutical industry for a long time, increasingly turn out to be unsuccessful. Despite improvements in rational drug design and high throughput screening methods, the number of novel, single-target drugs fell much behind expectations during the past decade, and the treatment of "complex

  16. Current status of and problems in ice heat storage systems contributing to improving load rate. Proliferation of the ice heat storage type air conditioning system and roles of the Heat Pump and Heat Storage Center; Fukaritsu kaizen ni kokensuru kori chikunetsu system no genjo to kadai. Kori chikunetsushiki kucho system no fukyu to heat pump chikunetsu center no yakuwari

    Energy Technology Data Exchange (ETDEWEB)

    Miyata, T.

    1998-02-01

    This paper introduces the roles played by the `Heat Pump and Heat Storage Center`. This foundation had been performing research and development and international information exchange in devices and equipment as the `Heat Pump Technology Development Center`. Development of heat storage type air conditioning systems as a measure for load leveling, and efforts of their proliferation and enlightenment were added to the business activities. As a result, the foundation`s name was changed to the present name. Its activities being planned and performed include: interest supplementing operation for installation of an air conditioning system of the heat pump system using storage of latent heat such as ice heat storage, holding seminars for promoting proliferation of the ice heat storage type air conditioning system, opening the home page, participation in exhibitions of various types, and preparation of different publicity tools. More specifically, carrying series advertisements in newspapers and magazines, holding nation-wide symposiums tying up with Japan Economic Press, publishing an organ newspaper targeted at both of experts and general people, and preparation of general pamphlets to introduce comprehensively the information about heat storage. 3 figs., 1 tab.

  17. NASA Goddard Space Flight Center Robotic Processing System Program Automation Systems, volume 2

    Science.gov (United States)

    Dobbs, M. E.

    1991-01-01

    Topics related to robot operated materials processing in space (RoMPS) are presented in view graph form. Some of the areas covered include: (1) mission requirements; (2) automation management system; (3) Space Transportation System (STS) Hitchhicker Payload; (4) Spacecraft Command Language (SCL) scripts; (5) SCL software components; (6) RoMPS EasyLab Command & Variable summary for rack stations and annealer module; (7) support electronics assembly; (8) SCL uplink packet definition; (9) SC-4 EasyLab System Memory Map; (10) Servo Axis Control Logic Suppliers; and (11) annealing oven control subsystem.

  18. Muon catalyzed fusion at very low temperature: A new target system

    International Nuclear Information System (INIS)

    Mulhauser, F.; Beveridge, J.L.; Marshall, G.M.

    1994-10-01

    Muon catalyzed fusion (μCF) processes are usually studied in gases or liquids. A new target system allows experiments on muonic hydrogen isotopes in solid hydrogen layers at 3K, where processes of the μCF cycle can be separated and the energy dependence of reactions can be measured. Muonic tritium atomic beams with energy of the order of 1 eV have been produced via transfer and emission from solid hydrogen target containing small tritium concentrations. The μt energy distribution overlaps the predicted muonic molecular (dμt) formation resonances. Preliminary time of flight results are shown. (author). 9 refs., 5 figs

  19. US8,994,532 "Data Center Equipment Location and Monitoring System"

    DEFF Research Database (Denmark)

    2014-01-01

    A data center equipment location system includes both hardware and software to provide for location, monitoring, security and identification of servers and other equipment in equipment racks. The system provides a wired alternative to the wireless RFID tag system by using electronic ID tags...... connected to each piece of equipment, each electronic ID tag connected directly by wires to a equipment rack controller on the equipment rack. The equipment rack controllers then link over a local area network to a central control computer. The central control computer provides an operator interface......, and runs a software application program that communicates with the equipment rack controllers. The software application program of the central control computer stores IDs of the equipment rack controllers and each of its connected electronic ID tags in a database. The software application program...

  20. Space Station Environmental Control and Life Support System Test Facility at Marshall Space Flight Center

    Science.gov (United States)

    Springer, Darlene

    1989-01-01

    Different aspects of Space Station Environmental Control and Life Support System (ECLSS) testing are currently taking place at Marshall Space Flight Center (MSFC). Unique to this testing is the variety of test areas and the fact that all are located in one building. The north high bay of building 4755, the Core Module Integration Facility (CMIF), contains the following test areas: the Subsystem Test Area, the Comparative Test Area, the Process Material Management System (PMMS), the Core Module Simulator (CMS), the End-use Equipment Facility (EEF), and the Pre-development Operational System Test (POST) Area. This paper addresses the facility that supports these test areas and briefly describes the testing in each area. Future plans for the building and Space Station module configurations will also be discussed.