Sample records for center responders exposed

  1. Exposing the Data Center


    Sergejev, Ivan


    Given the rapid growth in the importance of the Internet, data centers - the buildings that store information on the web - are quickly becoming the most critical infrastructural objects in the world. However, so far they have received very little, if any, architectural attention. This thesis proclaims data centers to be the 'churches' of the digital society and proposes a new type of a publicly accessible data center. The thesis starts with a brief overview of the history of data centers ...

  2. Hurricane Sandy Exposure and the Mental Health of World Trade Center Responders. (United States)

    Bromet, Evelyn J; Clouston, Sean; Gonzalez, Adam; Kotov, Roman; Guerrera, Kathryn M; Luft, Benjamin J


    The psychological consequences of a second disaster on populations exposed to an earlier disaster have rarely been studied prospectively. Using a pre- and postdesign, we examined the effects of Hurricane Sandy on possible World Trade Center (WTC) related posttraumatic stress disorder (PTSD Checklist score of ≥ 50) and overall depression (major depressive disorder [MDD]; Patient Health Questionnaire depression score of ≥ 10) among 870 WTC responders with a follow-up monitoring visit at the Long Island WTC Health Program during the 6 months post-Hurricane Sandy. The Hurricane Sandy exposures evaluated were damage to home (8.3%) and to possessions (7.8%), gasoline shortage (24.1%), prolonged power outage (42.7%), and filing a Federal Emergency Management Agency claim (11.3%). A composite exposure score also was constructed. In unadjusted analyses, Hurricane Sandy exposures were associated with 1.77 to 5.38 increased likelihood of PTSD and 1.58 to 4.13 likelihood of MDD; odds ratios for ≥ 3 exposures were 6.47 for PTSD and 6.45 for MDD. After adjusting for demographic characteristics, WTC exposure, pre-Hurricane Sandy mental health status, and time between assessments, reporting ≥ 3 Hurricane Sandy exposures was associated with a 3.29 and 3.71 increased likelihood of PTSD and MDD, respectively. These findings underscore the importance of assessing the impact of a subsequent disaster in ongoing responder health surveillance programs.

  3. Traumatic Responding in Children Exposed to Domestic Violence: A Cross-Cultural Study. (United States)

    Lehmann, Peter; Elliston, Ellen J.


    A study examined posttraumatic stress disorder in Mexican, Mexican American, and non-Mexican American children exposed to domestic violence. Surveys of 68 mothers with children in shelters in Mexico and Texas revealed no ethnic differences in children's overall trauma symptoms. Mothers' experience of physical and sexual abuse predicted greater…

  4. Risk, coping and PTSD symptom trajectories in World Trade Center responders. (United States)

    Feder, Adriana; Mota, Natalie; Salim, Ryan; Rodriguez, Janice; Singh, Ritika; Schaffer, Jamie; Schechter, Clyde B; Cancelmo, Leo M; Bromet, Evelyn J; Katz, Craig L; Reissman, Dori B; Ozbay, Fatih; Kotov, Roman; Crane, Michael; Harrison, Denise J; Herbert, Robin; Levin, Stephen M; Luft, Benjamin J; Moline, Jacqueline M; Stellman, Jeanne M; Udasin, Iris G; Landrigan, Philip J; Zvolensky, Michael J; Yehuda, Rachel; Southwick, Steven M; Pietrzak, Robert H


    Trajectories of disaster-related posttraumatic stress disorder (PTSD) symptoms are often heterogeneous, and associated with common and unique risk factors, yet little is known about potentially modifiable psychosocial characteristics associated with low-symptom and recovering trajectories in disaster responders. A total of 4487 rescue and recovery workers (1874 police and 2613 non-traditional responders) involved during and in the aftermath of the unprecedented World Trade Center (WTC) attacks, were assessed an average of 3, 6, 8, and 12 years post-9/11/2001. Among police responders, WTC-related PTSD symptoms were characterized by four trajectories, including no/low-symptom (76.1%), worsening (12.1%), improving (7.5%), and chronic (4.4%) trajectories. In non-traditional responders, a five-trajectory solution was optimal, with fewer responders in a no/low-symptom trajectory (55.5%), and the remainder in subtly worsening (19.3%), chronic (10.8%), improving (8.5%), and steeply worsening (5.9%) trajectories. Consistent factors associated with symptomatic PTSD trajectories across responder groups included Hispanic ethnicity, pre-9/11 psychiatric history, greater WTC exposure, greater medical illness burden, life stressors and post-9/11 traumas, and maladaptive coping (e.g., substance use, avoidance coping). Higher perceived preparedness, greater sense of purpose in life, and positive emotion-focused coping (e.g., positive reframing, acceptance) were negatively associated with symptomatic trajectories. Findings in this unique cohort indicate considerable heterogeneity in WTC-related PTSD symptom trajectories over 12 years post-9/11/2001, with lower rates of elevated PTSD symptoms in police than in non-traditional responders. They further provide a comprehensive risk prediction model of PTSD symptom trajectories, which can inform prevention, monitoring, and treatment efforts in WTC and other disaster responders.

  5. PTSD symptom dimensions and their relationship to functioning in World Trade Center responders. (United States)

    Ruggero, Camilo J; Kotov, Roman; Callahan, Jennifer L; Kilmer, Jared N; Luft, Benjamin J; Bromet, Evelyn J


    Post-traumatic stress disorder (PTSD) symptoms are common among responders to the 9/11 attacks on the World Trade Center and can lead to impairment, yet it is unclear which symptom dimensions are responsible for poorer functioning. Moreover, how best to classify PTSD symptoms remains a topic of controversy. The present study tested competing models of PTSD dimensions and then assessed which were most strongly associated with social/occupational impairment, depression, and alcohol abuse. World Trade Center responders (n=954) enrolled in the Long Island site of the World Trade Center Health Program between 2005 and 2006 were administered standard self-report measures. Confirmatory factor analysis confirmed the superiority of four-factor models of PTSD over the DSM-IV three-factor model. In selecting between four-factor models, evidence was mixed, but some support emerged for a broad dysphoria dimension mapping closely onto depression and contributing strongly to functional impairment. This study confirmed in a new population the need to revise PTSD symptom classification to reflect four dimensions, but raises questions about how symptoms are categorized. Results suggest that targeted treatment of symptoms may provide the most benefit, and that treatment of dysphoria-related symptoms in disaster relief workers may have the most benefit for social and occupational functioning.

  6. Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats. (United States)

    Guy, Elizabeth G; Fisher, Daniel C; Higgins, Guy A; Fletcher, Paul J


    Smoking tobacco remains one of the leading causes of preventable deaths in North America. Nicotine reinforces smoking behavior, in part, by enhancing the reinforcing properties of reward-related stimuli, or conditioned stimuli (CSs), associated with tobacco intake. To investigate how pharmaceutical interventions may affect this property of nicotine, we examined the effect of four US Food and Drug Administration (FDA) approved drugs on the ability of nicotine to enhance operant responding for a CS as a conditioned reinforcer. Thirsty rats were exposed to 13 Pavlovian sessions where a CS was paired with water delivery. Nicotine (0.4 mg/kg) injections were administered before each Pavlovian session. Then, in separate groups of rats, the effects of varenicline (1 mg/kg), bupropion (10 and 30 mg/kg), lorcaserin (0.6 mg/kg), and naltrexone (2 mg/kg), and their interaction with nicotine on responding for conditioned reinforcement were examined. Varenicline and lorcaserin each reduced nicotine-enhanced responding for conditioned reinforcement, whereas naltrexone had a modest effect of reducing response enhancements by nicotine. In contrast, bupropion enhanced the effect of nicotine on this measure. The results of these studies may inform how pharmaceutical interventions can affect smoking cessation attempts and relapse through diverse mechanisms, either substituting for, or interacting with, the reinforcement-enhancing properties of nicotine.

  7. Building academic health centers' capacity to shape and respond to comparative effectiveness research policy. (United States)

    VanLare, Jordan M; Conway, Patrick H; Rowe, John W


    In recent years, the focus on comparative effectiveness research (CER), the funding available to support it, and the range of possible effects of CER policy on academic health centers (AHCs) have increased substantially. CER has implications for the research, education, and clinical care components of AHCs' missions. The current funding and policy environment have created specific opportunities for AHCs to shape and respond to CER policies across the four dimensions of the CER enterprise: research, human and scientific capital, data infrastructure, and translation and dissemination. Characteristics such as the degree of physician-hospital integration, the status of a health information technology infrastructure, and the presence of a well-developed cross-functional health services research capacity linked to the care delivery enterprise could help AHCs respond to these opportunities and influence future policies. AHCs are also essential to the development of methodologies and the training of the next cadre of researchers. Further, a focus on understanding what works in health care and increasing adoption of evidence-based practice must become embedded in the fabric of AHCs. Those AHCs most successful in responding to the CER challenge may leverage it as a point of differentiation in the marketplace for health care and lead transformational improvements in health.

  8. Trends in Respiratory Symptoms of Firefighters Exposed to the World Trade Center Disaster: 2001–2005


    Webber, Mayris P.; Gustave, Jackson; Lee, Roy; Niles, Justin K.; Kelly, Kerry; Cohen, Hillel W.; David J Prezant


    Background Respiratory symptoms, either newly reported after the World Trade Center (WTC) disaster on 11 September 2001 (9/11) or increased in severity, have been well documented in WTC-exposed workers and New York City residents. However, considerable uncertainty exists over the persistence of symptoms. Objectives In this study, our goals were to describe trends in post-9/11 respiratory and gastro-esophageal reflux disease (GERD) symptoms in WTC-exposed firefighters and to examine symptom pr...

  9. Cue-centered treatment for youth exposed to interpersonal violence: a randomized controlled trial. (United States)

    Carrion, Victor G; Kletter, Hilit; Weems, Carl F; Berry, Rebecca Rialon; Rettger, John P


    This study provides preliminary evidence of the feasibility and efficacy of the Stanford cue-centered treatment for reducing posttraumatic stress, depression, and anxiety in children chronically exposed to violence. Sixty-five youth aged 8–17 years were recruited from 13 schools. Participants were randomly assigned to cue-centered treatment or a waitlist control group. Assessments were conducted at 4 discrete time points. Self-report measures assessed youth symptoms of posttraumatic stress disorder (PTSD), anxiety, and depression.Self-report ratings of caregiver anxiety and depression as well as caregiver report of child PTSD were also obtained. Therapists evaluated participants’ overall symptom improvement across treatment sessions. Hierarchal linear modeling analyses showed that compared to the waitlist group, the cue-centered treatment group had greater reductions in PTSD symptoms both by caregiver and child report, as well as caregiver anxiety. Cue-centered treatment, a hybrid trauma intervention merging diverse theoretical approaches, demonstrated feasibility,adherence, and efficacy in treating youth with a history of interpersonal violence.

  10. Responding to the Marketplace: Workforce Balance and Financial Risk at Academic Health Centers. (United States)

    Retchin, Sheldon M


    Elsewhere in this issue, Welch and Bindman present research demonstrating that academic health centers (AHCs) continue to disproportionately comprise specialists and subspecialist faculty physicians compared with community-based physician groups. This workforce composition has served AHCs well through the years-specialists fuel the clinical engine of the major tertiary and quaternary missions of AHCs, and they also dominate much of the clinical and translational research enterprise. AHCs are not alone-less than one-third of U.S. physicians practice primary care. However, health reform has prompted many health systems to reconsider this configuration. Payers, employers, and policy makers are shifting away from fee-for-service toward value-based care. Large community-based physician groups and their parent health systems appear to be far ahead of AHCs with a more balanced physician workforce. Many are leveraging their emphasis on primary care to participate in population health initiatives, such as accountable care organizations, and some own their own health plans. These approaches largely assume some element of financial risk and require both a more balanced workforce and an infrastructure to accommodate the management of covered lives. It remains to be seen whether AHCs will reconsider their own physician specialty composition to emphasize primary care-and, if they do, whether the traditional academic model, or a more community-based approach, will prevail.

  11. World Trade Center disaster exposure-related probable posttraumatic stress disorder among responders and civilians: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Bian Liu

    Full Text Available The World Trade Center (WTC disaster on September 11, 2001 was an unprecedented traumatic event with long-lasting health consequences among the affected populations in the New York metropolitan area. This meta-analysis aimed to estimate the risk of probable posttraumatic stress disorder (PTSD associated with specific types of WTC exposures. Meta-analytical findings from 10 studies of 3,271 to 20,294 participants yielded 37 relevant associations. The pooled summary odds ratio (OR was 2.05 (95% confidence interval (CI: 1.82, 2.32, with substantial heterogeneity linked to exposure classification, cohort type, data source, PTSD assessment instrument/criteria, and lapse time since 9/11. In general, responders (e.g. police, firefighters, rescue/recovery workers and volunteers had a lower probable PTSD risk (OR = 1.61; 95% CI: 1.39, 1.87 compared to civilians (e.g. residents, office workers, and passersby; OR = 2.71, 95% CI: 2.35, 3.12. The differences in ORs between responders and civilians were larger for physical compared to psychosocial exposure types. We also found that injury, lost someone, and witnessed horror were the three (out of six most pernicious exposures. These findings suggest that these three exposures should be a particular focus in psychological evaluation and treatment programs in WTC intervention and future emergency preparedness efforts.

  12. World Trade Center disaster exposure-related probable posttraumatic stress disorder among responders and civilians: a meta-analysis. (United States)

    Liu, Bian; Tarigan, Lukman H; Bromet, Evelyn J; Kim, Hyun


    The World Trade Center (WTC) disaster on September 11, 2001 was an unprecedented traumatic event with long-lasting health consequences among the affected populations in the New York metropolitan area. This meta-analysis aimed to estimate the risk of probable posttraumatic stress disorder (PTSD) associated with specific types of WTC exposures. Meta-analytical findings from 10 studies of 3,271 to 20,294 participants yielded 37 relevant associations. The pooled summary odds ratio (OR) was 2.05 (95% confidence interval (CI): 1.82, 2.32), with substantial heterogeneity linked to exposure classification, cohort type, data source, PTSD assessment instrument/criteria, and lapse time since 9/11. In general, responders (e.g. police, firefighters, rescue/recovery workers and volunteers) had a lower probable PTSD risk (OR = 1.61; 95% CI: 1.39, 1.87) compared to civilians (e.g. residents, office workers, and passersby; OR = 2.71, 95% CI: 2.35, 3.12). The differences in ORs between responders and civilians were larger for physical compared to psychosocial exposure types. We also found that injury, lost someone, and witnessed horror were the three (out of six) most pernicious exposures. These findings suggest that these three exposures should be a particular focus in psychological evaluation and treatment programs in WTC intervention and future emergency preparedness efforts.

  13. Birth outcome in HIV vertically-exposed children in two Romanian centers (United States)

    Tudor, Ana Maria; Mărdărescu, Mariana; Petre, Cristina; Neagu Drăghicenoiu, Ruxandra; Ungurianu, Rodica; Tilişcan, Cătălin; Oţelea, Dan; Cambrea, Simona Claudia; Tănase, Doina Eugenia; Schweitzer, Ana Maria; Ruţă, Simona


    Background The Romanian HIV epidemic is characterized by a high prevalence among children born in the late ’80s, perinatally infected. The impact of long-term treatment on their offspring is unknown. We evaluated the influence of prenatal care on the rate of premature birth among the HIV-exposed children of heavily treated HIV-infected mothers in two Romanian centers. Methods We retrospectively analyzed data on all patients born by HIV-infected mothers between 2006 and 2012 followed up in two main regional centers. We compared the rate of premature birth and the differences between the sites regarding children and maternal demographic characteristics and antiretroviral exposure in pregnant women. Results A total of 358 children born to 315 women were enrolled between 2006-2012, 262 children from the National Institute for Infectious Diseases “Prof. Dr. Matei Balş” Bucharest (NIID) and 96 children from the Clinical Infectious Diseases Hospital Constanţa (IDHC). Gender rate in newborns and mean age in mothers were similar. We recorded statistically significant differences between centers in the rate of HIV vertical transmission (16.8% vs. 6.2%, p=0.002) and prematurity (25.2 vs. 14.6%, p=0.023). The most used antiretroviral combination during pregnancy in IDHC was boosted lopinavir and fixed dose zidovudine-lamivudine (66% of cases), while in NIID a greater diversity of antiretrovirals were used. Women from IDHC were more frequently treated during pregnancy (83.3% vs. 68.6%, p=0.004). HCV coinfection and illegal drug use were associated with prematurity in the NIID cohort (p=0.037, p=0.024). Conclusion We found a higher rate of premature birth and HIV infection in NIID. In IDHC we found a higher rate of low birth weight in children and a higher rate of heavily treated women. Prematurity was associated with hepatitis C infection and illegal drug use in the NIID cohort. PMID:26716100

  14. Serum perfluoroalkyl substances in children exposed to the world trade center disaster. (United States)

    Trasande, Leonardo; Koshy, Tony T; Gilbert, Joseph; Burdine, Lauren K; Attina, Teresa M; Ghassabian, Akhgar; Honda, Masato; Marmor, Michael; Chu, Dinh Binh; Han, Xiaoxia; Shao, Yongzhao; Kannan, Kurunthachalam


    The World Trade Center (WTC) disaster released large amounts of various chemical substances into the environment, including perfluoroalkyl substances (PFASs). Yet, no studies have examined exposures in children living or attending schools near the disaster site. We measured serum PFASs in WTC Health Registry (WTCHR) respondents who were ≤8 years of age on September 11, 2001 and a sociodemographically-matched comparison group. We also examined the relationship of PFASs levels with dust cloud exposure; home dust exposure, and with traumatic exposure, the latter to take into account differences related to possible mental health consequences and associated behavioral problems. Serum samples, collected between 2014 and 2016, were analyzed from 123 WTCHR participants and from 185 participants in the comparison group. In the WTCHR group, median perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) levels were 1.81ng/mL and 3.72ng/mL, respectively. Controlling for sex, caloric intake, race/ethnicity, and date of birth, significant increases among WTCHR participants compared with the matched comparison group were detected for perfluorohexanesulfonate (0.23ng/mL increase or 0.24log unit increase, p=0.006); PFOS (0.86ng/mL increase or 0.16log unit increase, p=0.011); PFOA (0.35ng/mL increase or 0.18log unit increase, p<0.001); perfluorononanoic acid (0.12ng/mL increase or 0.17log unit increase, p=0.003); perfluorodecanoic acid (0.06ng/mL increase or 0.42log unit increase, p<0.001); and perfluoroundecanoic acid (0.03ng/mL increase or 0.32log unit increase, p=0.019). Stronger associations were identified for home dust exposures and traumatic exposures than dust cloud. These findings highlight the importance of conducting longitudinal studies in this population to assess possible cardiometabolic and renal consequences related to these exposures.

  15. Center-Based Early Head Start and Children Exposed to Family Conflict (United States)

    Whiteside-Mansell, Leanne; Bradley, Robert; McKelvey, Lorraine; Lopez, Maya


    Research Findings: Family conflict is known to be associated with poor development for young children, but many children appear resilient. This study examined the extent to which high-quality center care during early childhood protects children from these negative consequences. Children participating in center-based sites of the Early Head Start…

  16. Using science centers to expose the general public to the microworld

    Energy Technology Data Exchange (ETDEWEB)

    Malamud, E. [Fermi National Accelerator Lab., Batavia, IL (United States)]|[Science and Technology Interactive Center, Aurora, IL (United States)


    Despite the remarkable progress in the past decades in understanding our Universe, we particle physicists have failed to communicate the wonder, excitement, and beauty of these discoveries to the general public. I am sure all agree there is a need, if our support from public funds is to continue at anywhere approximating the present level, for us collectively to educate and inform the general public of what we are doing and why. Informal science education and especially science and technology centers can play an important role in efforts to raise public awareness of particle physics in particular and of basic research in general. Science Centers are a natural avenue for particle physicists to use to communicate with and gain support from the general public.

  17. Melanomacrophage centers in kidney, spleen and liver: A toxic response in carp fish (Cyprinus carpio) exposed to mercury chloride (United States)

    Tjahjaningsih, Wahju; Pursetyo, Kustiawan Tri; Sulmartiwi, Laksmi


    This study aims to determine the potential of melanomacrophage centers (MMCs) as a bioindicators of environment polluted with mercury chloride. This study used the carp fish that were kept in an environment that contained mercury chloride with a concentration of 0.01, 0.05 and 0.1 ppm for 21 days. The rate of accumulation of macrophages in the tissue of kidney, spleen and liver were measured by the activity of N-acetylglucosaminidase. The results showed that the MMCs in the spleen and liver tissue of the carp fish potential as the bio-indicators of polluted environment ≥0.1 ppm of mercury chloride. The increased in accumulation of macrophages found in the kidney tissue of carp fish exposed to mercury chloride concentration of 0.01, 0.05 and 0.1 ppm, although no significant difference with control (0 ppm). The suppressive effect of the accumulation of immune response showed at the carp fish liver tissue macrophages which were exposed to mercury chloride lower than carp fish that were not exposed.

  18. Academics respond

    DEFF Research Database (Denmark)

    Hazel, Spencer


    Contribution to the article "Academics respond: Brexit would weaken UK university research and funding", Guardian Witness, The Guardian, UK......Contribution to the article "Academics respond: Brexit would weaken UK university research and funding", Guardian Witness, The Guardian, UK...

  19. Thermoluminescence and F centers of manganese doped NaCl and NaCl-CKl crystals exposed to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Somera, L.; Cruz Z, E.; Roman L, J. [UNAM, Instituto de Ciencias Nucleares, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Hernandez A, J. M.; Murrieta S, H., E-mail: [UNAM, Instituto de Fisica, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)


    Alkali halides crystals doped with rare earths or transition metals have been widely studied due to the luminescence properties. In particular, NaCl and KCl single crystals present thermally stimulated luminescence (Tl) after gamma irradiation. The NaCl and the NaCl KCl mixed crystal doped with manganese (MnCl{sub 2}) impurity were grown by using the Czochralski method. The emission characteristic of Mn{sup 2+} was observed at 543 nm. The crystals were exposed between 0.02 and 10 kGy gamma dose from {sup 60}Co irradiator. Optical absorption at room temperature shows the peaked band at 452 nm corresponding to the manganese impurity. The F bands, was ascribed to the electron trapped in the anion vacancy in the lattice, were obtained at 452 nm and 455 nm belonging to NaCl:Mn and NaCl KCl:Mn, respectively. The F band increases as the doses increase and it was bleaching by the UV light at 470 nm. The glow curves of the samples show the first glow peak between 92-103 degrees C, while the second main peak was observed at 183 degrees C for the undoped NaCl and at 148 and 165 degrees C for the NaCl:Mn and NaCl-KCl:Mn, respectively. The main peak was slowly bleaching when the irradiated sample was illuminated with F (470 nm) light. Optical bleaching confirms that the F center has an important participation in the thermoluminescent response. The glow curves structure from the thermal bleaching suggests the participation of different kind of traps. Also, the kinetics parameters such as activation energy (E), frequency factor (s) and the kinetic order (b) were investigated. (Author)

  20. Posttraumatic stress symptoms and body mass index among World Trade Center disaster-exposed smokers: A preliminary examination of the role of anxiety sensitivity. (United States)

    Farris, Samantha G; Paulus, Daniel J; Gonzalez, Adam; Mahaffey, Brittain L; Bromet, Evelyn J; Luft, Benjamin J; Kotov, Roman; Zvolensky, Michael J


    Among individuals exposed to the World Trade Center (WTC) disaster on September 11, 2001, posttraumatic stress disorder (PTSD) and symptoms are both common and associated with increased cigarette smoking and body mass. However, there is little information on the specific processes underlying the relationship of PTSD symptoms with body mass. The current study is an initial exploratory test of anxiety sensitivity, the fear of internal bodily sensations, as a possible mechanism linking PTSD symptom severity and body mass index (BMI). Participants were 147 adult daily smokers (34.0% female) exposed to the WTC disaster (via rescue/recovery work or direct witness). The direct and indirect associations between PTSD symptom severity and BMI via anxiety sensitivity (total score and subscales of physical, cognitive, and social concerns) were examined. PTSD symptom severity was related to BMI indirectly via anxiety sensitivity; this effect was specific to physical concerns about the meaning of bodily sensations. Interventions focusing on anxiety sensitivity reduction (specifically addressing physical concerns about bodily sensations) may be useful in addressing elevated BMI among trauma-exposed persons.

  1. St. John's Wort in patients non-responders to clopidogrel undergoing percutaneous coronary intervention: a single-center randomized open-label trial (St. John's Trial). (United States)

    Trana, Catalina; Toth, Gabor; Wijns, William; Barbato, Emanuele


    We assessed if St. John's Wort (SJW) improves platelet response in patients (pts) resistant to clopidogrel after percutaneous coronary intervention (PCI). Stable angina pts non-responders to 600 mg clopidogrel (P2Y12 reaction units (PRU) >240) were randomized (2:1) to SJW (n = 15) or placebo (n = 8). SJW (300 mg × 3/day) was administrated for 2 weeks after PCI. Platelet reactivity was assessed by VerifyNowTM before (BL), 2 (T1), and 4 weeks (T2) after PCI. PRU significantly changed during protocol in SJW (BL (316 ± 60) vs. T1 (170 ± 87) vs. T2 (220 ± 96), p < 0.0001) and placebo group (BL (288 ± 36) vs. T1 (236 ± 31) vs. T2 (236 ± 62), p = 0.046). Yet, PRU changes from BL were higher at T1 in SJW than in placebo group (Δ%, -47 ± 24 vs. -16 ± 15, p = 0.0033), with no differences at T2 between the groups (Δ%, -30 ± 29 vs. -17 ± 24, p = 0.30). Residual platelet reactivity improved with SJW during the first month post-PCI.

  2. The Conscientious Responders Scale

    Directory of Open Access Journals (Sweden)

    Zdravko Marjanovic


    Full Text Available This investigation introduces a novel tool for identifying conscientious responders (CRs and random responders (RRs in psychological inventory data. The Conscientious Responders Scale (CRS is a five-item validity measure that uses instructional items to identify responders. Because each item instructs responders exactly how to answer that particular item, each response can be scored as either correct or incorrect. Given the long odds of answering a CRS item correctly by chance alone on a 7-point scale (14.29%, we reasoned that RRs would answer most items incorrectly, whereas CRs would answer them correctly. This rationale was evaluated in two experiments in which CRs’ CRS scores were compared against RRs’ scores. As predicted, results showed large differences in CRS scores across responder groups. Moreover, the CRS correctly classified responders as either conscientious or random with greater than 93% accuracy. Implications for the reliability and effectiveness of the CRS are discussed.

  3. Alveolar epithelial cells (A549) exposed at the air-liquid interface to diesel exhaust: First study in TNO's powertrain test center

    NARCIS (Netherlands)

    Kooter, I.M.; Alblas, M.J.; Jedynska, A.D.; Steenhof, M.; Houtzager, M.M.G.; Ras, M.G. van


    Air–liquid interface (ALI) exposures enable in vitro testing ofmixtures of gases and particles such as diesel exhaust (DE). The main objective of this study was to investigate the feasibility of exposing human lung epithelial cells at the ALI to complete DE generated by a heavy-duty truck in the sta

  4. Threshold Shifts and Cochlear Injury in Chinchillas Exposed to Octave Bands of Noise Centered at 63 and 1000 HZ for 9 Days, (United States)


    2.0 kHz. The 1000-Hz octave bands produced more permanent threshold shift at the lower 33 %.. . %. , Ic CV) 1 00 EuG LLS) 2C C LJ5- 0o x ezw CA OJ...Officer Commander Naval Medical R&D Command US Army Transportation School National Naval Medical Center ATTN: ATSPoTD-ST Bethesda, 1D 20014 (1) Fort

  5. Exposing diversity

    DEFF Research Database (Denmark)

    Nørtoft, Kamilla; Nordentoft, Helle Merete

    . A prominent research theme in health care studies is, therefore, to explicate the gap between theory and practice. The question this paper addresses is how a learning environment can be designed to bridge this theory-practice gap, expose the differences in situated interactions and qualify health...... in the homes of older people and in pedagogical institutions targeting older people. In the paper we look at the potentials and challenges in working with ethnographic video narratives as a pedagogical tool. Our findings indicate that the use of video narratives has the potential to expose the diversity...

  6. 76 FR 6475 - Emergency Responder Health Monitoring and Surveillance (United States)


    ... HUMAN SERVICES Centers for Disease Control and Prevention Emergency Responder Health Monitoring and... responder safety and health by monitoring and conducting surveillance of their health and safety during the... of a response. The proposed system is referred to as the ``Emergency Responder Health Monitoring...

  7. Sixteen Textbook Authors Respond. (United States)

    Hewitt, John P.; And Others


    The articles on textbook publication written by Sheryl Fullerton and Franklin C. Graham were responded to by: John Hewitt, Henry Tischler, George Ritzer, Paul Baker, Erich Goode, D. Stanley Eitzen, Jon Shepard, Richard Schaefer, Caroline Persell, Beth Hess, Paul Zopf, Jr., Jeanne Ballantine, Duane Monette, Mary Ann Lamanna, John Macionis, and…

  8. The Gesell Institute Responds. (United States)

    Young Children, 1987


    Responding to Dr. Meisels' article concerning the uses and abuses of the Gesell readiness tests, the Gesell Institute of Child development maintains that the Gesell series of assessments are used by schools to gain a fuller developmental understanding of the child and have been predictive of school success. (BB)

  9. Responding to Individual Needs. (United States)

    Ainscow, Mel


    Effective teachers of students with disabilities respond successfully to students' individual needs by ensuring that students understand the purpose of their activities, by presenting students with variety and choice, by encouraging them to reflect upon and review their learning, by making flexible use of time and resources, and by implementing…

  10. Responding to Mechanical Antigravity (United States)

    Millis, Marc G.; Thomas, Nicholas E.


    Based on the experiences of the NASA Breakthrough Propulsion Physics Project, suggestions are offered for constructively responding to proposals that purport breakthrough propulsion using mechanical devices. Because of the relatively large number of unsolicited submissions received (about 1 per workday) and because many of these involve similar concepts, this report is offered to help the would-be submitters make genuine progress as well as to help reviewers respond to such submissions. Devices that use oscillating masses or gyroscope falsely appear to create net thrust through differential friction or by misinterpreting torques as linear forces. To cover both the possibility of an errant claim and a genuine discovery, reviews should require that submitters meet minimal thresholds of proof before engaging in further correspondence; such as achieving sustained deflection of a level-platform pendulum in the case of mechanical thrusters.

  11. 911 Call Center (PSAP) Service Areas, Important layer used in County Dispatch for routing first responders. Created using the County USPLS and documented reports on correct boundaries, Published in 2012, Not Applicable scale, Chippewa County. (United States)

    NSGIC GIS Inventory (aka Ramona) — This 911 Call Center (PSAP) Service Areas dataset, published at Not Applicable scale, was produced all or in part from Field Survey/GPS information as of 2012. It is...

  12. Responding to Outbreaks

    Centers for Disease Control (CDC) Podcasts


    In this podcast, a team of CDC specialists travels to Uganda and tracks the source of an Ebola outbreak where CDC scientists are studying bats for clues to the Ebola mystery.  Created: 4/27/2009 by National Center for Zoonotic, Vector-Borne, and Enteric Diseases (NCZVED).   Date Released: 4/27/2009.

  13. 2015 QuickCompass of Sexual Assult-Related Responders: Statistical Methodology Report (United States)


    AND RESPONSE-RELATED RESPONDERS: STATISTICAL METHODOLOGY REPORT Defense Research , Surveys, and Statistics Center Defense Manpower Data Center...2015 QuickCompass of Sexual Assault Prevention and Response- Related Responders Statistical Methodology Report Additional copies of this report...Defense Research , Surveys, and Statistics Center (RSSC) 4800 Mark Center Drive, Suite 04E25-01, Alexandria, VA 22350-4000 ii Acknowledgments

  14. Responder Technology Alert (February 2015)

    Energy Technology Data Exchange (ETDEWEB)

    Upton, Jaki F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stein, Steven L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)


    As part of technology foraging for the Responder Technology Alliance, established by the Department of Homeland Science and Technologies First Responders Group, this report summarizes technologies that are relevant in the area of “wearables,” with the potential for use by first responders. The content was collected over the previous month(s) and reproduced from a general Internet search using the term wearables. Additional information is available at the websites provided. This report is not meant to be an exhaustive list nor an endorsement of any technology described herein. Rather, it is meant to provide useful information about current developments in the areas wearable technology.

  15. Respondent Learning and Classroom Practice (United States)

    Roden, Aubrey H.; Hapkiewicz, Walter G.


    This discussion is based on the premise that a significant proportion of school learning is emotional or affective and that much of this learning is in the form of classical conditioning or respondent learning. (Authors/JA)

  16. How Career Centers Are Responding to the Budget Crunch. (United States)

    Klein, Paul B.; Step, Mary M.


    Surveyed career services offices (n=42) to determine effects of current budget crisis and strategies used to make up for deficits in operating budget and to produce a profile of services and population served. Found offices were raising fees, refining focus and efficiency, soliciting outside support, using paraprofessionals more, and doing more…

  17. A Human-Centered Approach to Sense and Respond Logistics (United States)


    International Journal of Industrial Ergonomics . Nam...research and development organizations: The characteristics of successful teams. International Journal of Industrial Ergonomics , 16(1), 29-42...3), 356-376. May, A., & Carter, C. (2001). A case study of virtual team working in the European automotive industry. International Journal of Industrial Ergonomics ,

  18. Aromatase Inhibitors for IVF Poor Responders

    Institute of Scientific and Technical Information of China (English)

    R.B. Quintero; L.C Giudice; L.M. Westphal


    Objective To evaluate whether letrozole enhanced follicular recruitment, embryo numbers, and pregnancy rates in poor responders undergoing IVF.Methods We reviewed all IVF cycles between January 2002 and September 2003 using letrozole at Stanford University Medical Center. The entry criteria were the requirement of at least 450 IU/d of injectable gonadotropins in a prior failed cycle,which was used as a control.Results A total of 27 charts were reviewed revealing information on 54 cycles. The number of oocytes retrieved, fertilization embryo quality and embryos transferred yielded no statistical significance, although there appeared to be a trend toward higher numbers of each in the letrozole group. The clinical pregnancy rate was 9/27 (33.3%, P<0. 001)with a viable pregnancy rate of 7/27 (25.9%, P=0.002) in the letrozole cycle.Conclusion Our study is one of the first to evaluate letrozole with in vitro fertilization.Although this study showed no difference in number of oocytes or embryos, 25.9% of these "poor responding" patients achieved a pregnancy after a failed cycle at our center.

  19. Parental exposure to mass violence and child mental health: the First Responder and WTC Evacuee Study. (United States)

    Hoven, Christina W; Duarte, Cristiane S; Wu, Ping; Doan, Thao; Singh, Navya; Mandell, Donald J; Bin, Fan; Teichman, Yona; Teichman, Meir; Wicks, Judith; Musa, George; Cohen, Patricia


    Children's reactions after being exposed to mass violence may be influenced by a spectrum of factors. Relatively unexplored is the extent to which family exposure to mass violence may affect child mental health, even when these children have not been directly exposed. In a representative sample of NYC public school children assessed 6 months after the September 11, 2001 attack on the World Trade Center (WTC), seemingly elevated rates of psychopathology were recorded among children of WTC evacuees. Children of NYC First Responders (police officers, EMTs, and fire fighters) displayed a complex pattern of response to the WTC attack. Overall, the findings from this previous study support putative transmission of trauma to children whose parents were exposed to the WTC attack. The "Children of First Responder and WTC Evacuee Study"-a two-site longitudinal study-is currently underway in the United States (New York City) and in Israel (Tel Aviv area) in an effort to understand the impact of different patterns of mass violence. The NYC sample permits us to examine the impact of a rare instance of mass violence (e.g., WTC attack), while the Israeli sample provides information about repeated and frequent exposure to mass violence brought about by acts of terrorism. In addition, children's exposure to mass violence is considered in the context of their exposure to other potentially traumatic events. This study aims to improve our general understanding of the impact of mass violence on children, especially the psychological effects on children whose parents' work experiences are by nature stressful. Knowledge generated by this study has implications for guiding efforts to meet the needs of children who have, directly or through a family member, been subjected to rare or infrequent mass violent event as well as to children whose exposure to mass violence is part of daily life.

  20. Learning as Calling and Responding (United States)

    Jons, Lotta


    According to Martin Buber's philosophy of dialogue, our being-in-the-world is to be conceived of as an existential dialogue. Elsewhere, I have conceptualized the teacher-student-relation accordingly (see Jons 2008), as a matter of calling and responding. The conceptualization rests on a secularised notion of vocation, paving way for…

  1. Responding to the Invisible Student. (United States)

    Callahan, Susan


    Investigates what constitutes good reflection. Describes how one instructor used the Myers-Briggs type indicator (MBTI) to explore her responses to the reflective writing produced by preservice English teachers. Concludes that the MBTI can provide insight into and improve how instructors assign, respond to, and evaluate student reflection.…

  2. Project Responder: technology needs for local emergency response (United States)

    Beakley, Guy; Garwin, Thomas; Pollard, Neal A.; Singley, George T., III; Tuohy, Robert V.; Lupo, Jasper


    Since April 2001, the Oklahoma City National Memorial Institute for the Prevention of Terrorism has funded an effort by Hicks &Associates, Inc. and the Terrorism Research Center, Inc., aimed ultimately at improving local, state, and federal emergency responders" capabilities for mitigating the effects of chemical, biological, radiological, nuclear or explosive/ incendiary (CBRNE) terrorism. This effort, titled "Project Responder," began by developing an understanding of how state and local responders view their current capabilities, shortfalls, and needs. This paper discusses some of the results of this first phase of the effort that has resulted in a comprehensive report titled "Emergency Responders" Needs, Goals, and Priorities." This paper addresses two of the capabilities from that report which we believe are of most interest to this conference. There are ten other capabilities discussed in the report, which may also be of interest.

  3. Biodetection Technologies for First Responders

    Energy Technology Data Exchange (ETDEWEB)

    Baird, Cheryl L.; Seiner, Derrick R.; Ozanich, Richard M.; Bartholomew, Rachel A.; Colburn, Heather A.; Straub, Tim M.; Bruckner-Lea, Cindy J.


    In a white powder scenario, there are a large number of field-deployable assays that can be used to determine if the suspicious substance contains biological material and warrants further investigation. This report summarizes commercially available technologies that are considered hand portable and can be used by first responders in the field. This is not meant to be an exhaustive list, nor do the authors endorse any of the technologies described herein. Rather, it is meant to provide useful information about available technologies to help end-users make informed decisions about biodetection technology procurement and use.

  4. The National Homeland Security Research Center (United States)

    Federal Laboratory Consortium — The National Homeland Security Research Center advances our nation's security by providing scientific products and expertise to improve the ability to respond to and...

  5. 37 CFR 41.68 - Respondent's brief. (United States)


    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Respondent's brief. 41.68... Respondent's brief. (a)(1) Respondent(s) in an appeal may once, within the time limit for filing set forth in... title. (2) The brief must be signed by the party, or the party's duly authorized attorney or agent,...

  6. What is wrong with non-respondents?

    DEFF Research Database (Denmark)

    Christensen, Anne Illemann; Ekholm, Ola; Gray, Linsay


    and different types of non-respondents to estimate alcohol-, drug- and smoking related mortality and morbidity among non-respondents. DESIGN: Prospective follow-up study of respondents and non-respondents in two cross-sectional health surveys. SETTING: Denmark. PARTICIPANTS: A total sample of 39,540 Danish...

  7. Drug use among complete responders, partial responders and non-responders in a longitudinal survey of nonagenarians

    DEFF Research Database (Denmark)

    Wastesson, Jonas W; Rasmussen, Lotte; Oksuzyan, Anna;


    PURPOSE: In observational studies, non-response can limit representativity and introduce bias. We aimed to investigate the longitudinal changes in the number of used drugs among complete responders, partial responders, and non-responders in a whole birth cohort of Danish nonagenarians participating...... in a longitudinal survey. METHODS: We obtained prescription data on all individuals born in 1905 and living in Denmark when the Danish 1905 cohort study was initiated in 1998 (n = 3600) using the Danish National Prescription Registry. Drug use was assessed for complete responders, non-responders at baseline......, and partial responders (i.e., dropouts) in the 4-month period preceding each wave of the study (1998, 2000, 2003, and 2005), that is, as the cohort aged from 92-93 to 99-100 years. RESULTS: Complete responders, non-responders, and partial responders used a similar number of drugs at baseline, on average 4...

  8. Testosterone for Poor Ovarian Responders

    DEFF Research Database (Denmark)

    Polyzos, Nikolaos P; Davis, Susan R; Drakopoulos, Panagiotis


    ovarian stimulation with a duration varying from 5 to 21 days. Nevertheless, the key question to be asked is whether, based on ovarian physiology and testosterone pharmacokinetics, a short course of testosterone administration of more than 10 mg could be expected to have any beneficial effect...... on reproductive outcome. The rationale for asking this question lies in the existing scientific evidence derived from basic research and animal studies regarding the action of androgens during folliculogenesis, showing that their main effect in follicular development is defined during the earlier developmental...... stages. In addition, extreme testosterone excess is not only likely to induce adverse events but has also the potential to be ineffective and even detrimental. Thus, evidence from clinical studies is not enough to either "reopen" or "close" the "androgen chapter" in poor responders, mainly because...

  9. Como responder ao momento presente?

    Directory of Open Access Journals (Sweden)

    Maria Filomena Molder


    Full Text Available Foi com esta pergunta — já um efeito de um primeiro encontro entre Irene Pimentel e eu própria — que decidimos desafiar colegas, estudantes e funci­onários da nossa Faculdade, FCSH (Faculdade de Ciências Sociais e Huma­nas, de outras Faculdades da Universidade Nova de Lisboa, de outras Uni­versidades e todos os interessados em con­siderar e discutir em comum aquilo que se passava em Portugal e que no anúncio da Jornada de 6 de De­zembro de 2012 se descrevia como um “processo de desmantela­mento social, económico e cultural sem precedentes — pese embora tantas compara­ções, baseadas na premissa da ‘eterna repetição’ — e cujas consequências não param de exceder as previsões dos responsáveis por esse desmantelamento”. Acedendo com todo o empenho e gratidão ao convite que me foi dirigido por Humberto Brito para fazer uma resenha da Jornada a publicar no primeiro número de Forma de Vida (saúdo a revista e o título, decidi-me, no entanto, a pôr de lado a resenha, que sob a forma de “Editorial” será em breve publi­cada no blogue Responder ao Momento Presente, entre­tanto criado, conjuntamente com os textos escritos pelos nossos convidados, com as parti­cipações de pessoas que corresponderam ao nosso apelo e ainda com contri­bui­ções que se alargaram para lá da Jornada; a que se juntará uma gravação em video, também disponível no Youtube. Texto publicado originalmente em Forma de Vida, Lisboa, n.1, fev. 2013. Agrade­cemos à autora por permitir a republicação neste número do Boletim. [N.E.

  10. Fire exposed aluminium structures

    NARCIS (Netherlands)

    Maljaars, J.; Fellinger, J.H.H.; Soetens, F.


    Material properties and mechanical response models for fire design of steel structures are based on extensive research and experience. Contrarily, the behaviour of aluminium load bearing structures exposed to fire is relatively unexplored. This article gives an overview of physical and mechanical pr

  11. Violence perception and victimization reasons of women exposed to spouse/partner violence

    Directory of Open Access Journals (Sweden)

    Hatice Baskale


    Full Text Available Aim: The aim of this study was to determine violence perception and victimization reasons of women exposed to spouse/partner violence who applied to the violence prevention and monitoring center. Methods: This study is a descriptive survey in order to determine violence perception and victimization reasons of women who applied because of violence. This study was made on women who exposed to spouse/partner violence applied to the violence prevention and monitoring center in the west of Turkey. In these dates 137 women applied to the violence prevention and monitoring center. We reached 51% of universe. In the study, demographic information was collected through the survey method face to face interviews consisted of questions which identify the causes of violence and victimization perception. Results: 31.4% of the women participating in the study exposed to violence for 1-5 years, 21.4% of them exposed for 11-15 years. 74.3% of women share violence with others, women who didn't share with others because of they didn't know what to do and where to apply. Children have witnessed domestic violence, 51.4% were exposed to the violence. causes of violence were determined as economic problems, spouse / partner's alcohol / substance abuse, women are responding to partner, he does not want his wife, and has been identified as not prompted by his partner's family. 91.4% of women don't participate in the idea of violence was sometimes necessary, 81.4% don't think not so much violence against women can be seen joining excused. 62.9% of them think people who experience violence would behave similarly. Most of the women exposed to violence think if there is violence when women-man arguing the bond of love will be extinction, 84.3% think violence is not a solution, and 14.3% stated that it might be a solution. Conclusion: Health personnel are the group that can identify the violence, can be found in initiatives and can lead women to cope. Steps to be taken to

  12. Evaluation of Respondent-Driven Sampling


    McCreesh, N; Frost, SD; Seeley, J.; Katongole, J; Tarsh, MN; Ndunguse, R; Jichi, F; Lunel, NL; Maher, D.; Johnston, LG; Sonnenberg, P; Copas, AJ; Hayes, RJ; White, RG


    : BACKGROUND:: Respondent-driven sampling is a novel variant of link-tracing sampling for estimating the characteristics of hard-to-reach groups, such as HIV prevalence in sex workers. Despite its use by leading health organizations, the performance of this method in realistic situations is still largely unknown. We evaluated respondent-driven sampling by comparing estimates from a respondent-driven sampling survey with total population data. METHODS:: Total population data on age, tribe, rel...

  13. Responding to Students' Learning Preferences in Chemistry (United States)

    Lewthwaite, Brian; Wiebe, Rick


    This paper reports on a teacher's and his students' responsiveness to a new tetrahedral-oriented (Mahaffy in J Chem Educ 83(1):49-55, 2006) curriculum requiring more discursive classroom practices in the teaching of chemistry. In this instrumental case study, we identify the intentions of this learner-centered curriculum and a teacher's development in response to this curriculum. We also explore the tensions this teacher experiences as students subsequently respond to his adjusted teaching. We use a Chemistry Teacher Inventory (Lewthwaite and Wiebe in Res Sci Educ 40(11):667-689, 2011; Lewthwaite and Wiebe in Can J Math Sci Technol Educ 12(1):36-61, 2012; Lewthwaite in Chem Educ Res Pract. doi:10.1039/C3RP00122A, 2014) to assist the teacher in monitoring how he teaches and how he would like to improve his teaching. We also use a student form of the instrument, the Chemistry Classroom Inventory and Classroom Observation Protocol (Lewthwaite and Wiebe 2011) to verify the teacher's teaching and perception of student preferences for his teaching especially in terms of the discursive processes the curriculum encourages. By so doing, the teacher is able to use both sets of data as a foundation for critical reflection and work towards resolution of the incongruence in data arising from students' preferred learning orientations and his teaching aspirations. Implications of this study in regards to the authority of students' voice in triggering teachers' pedagogical change and the adjustments in `teachering' and `studenting' required by such curricula are considered.

  14. Smart radio: spectrum access for first responders (United States)

    Silvius, Mark D.; Ge, Feng; Young, Alex; MacKenzie, Allen B.; Bostian, Charles W.


    This paper details the Wireless at Virginia Tech Center for Wireless Telecommunications' (CWT) design and implementation of its Smart Radio (SR) communication platform. The CWT SR can identify available spectrum within a pre-defined band, rendezvous with an intended receiver, and transmit voice and data using a selected quality of service (QoS). This system builds upon previous cognitive technologies developed by CWT for the public safety community, with the goal of providing a prototype mobile communications package for military and public safety First Responders. A master control (MC) enables spectrum awareness by characterizing the radio environment with a power spectrum sensor and an innovative signal detection and classification module. The MC also enables spectrum and signal memory by storing sensor results in a knowledge database. By utilizing a family radio service (FRS) waveform database, the CWT SR can create a new communication link on any designated FRS channel frequency using FM, BPSK, QPSK, or 8PSK modulations. With FM, it supports analog voice communications with legacy hand-held FRS radios. With digital modulations, it supports IP data services, including a CWT developed CVSD-based VoIP protocol. The CWT SR coordinates spectrum sharing between analog primary users and digital secondary users by applying a simple but effective channel-change protocol. It also demonstrates a novel rendezvous protocol to facilitate the detection and initialization of communications links with neighboring SR nodes through the transmission of frequency-hopped rendezvous beacons. By leveraging the GNU Radio toolkit, writing key modules entirely in Python, and utilizing the USRP hardware front-end, the CWT SR provides a dynamic spectrum test bed for future smart and cognitive radio research.

  15. Mobile-Only Web Survey Respondents

    NARCIS (Netherlands)

    Lugtig, P.J.; Toepoel, V.; amin, alerk


    Web surveys are no longer completed on just a desktop or laptop computer. Respondents increasingly use mobile devices, such as tablets and smartphones to complete web surveys. In this article, we study how respondents in the American Life Panel complete surveys using varying devices. We show that ab

  16. 广西市级疾控机构突发公共卫生事件应对能力现况调查%Capacity to respond to public health emergencies of the municipal level centers for disease control and prevention in Guangxi Zhuang Autonomous Region

    Institute of Scientific and Technical Information of China (English)

    刘德诚; 陈发钦; 周阳; 韦辉; 冯启明


    Objective To investigate the capacity to respond to public health emergencies of the municipal level Centers for Disease Control and Prevention (CDC) in Guangxi. Methods A questionnaire survey was conducted among the directors of all 14 municipality-level CDC in Guangxi to understand the relative situations. Results There were 1 770 staff members in these 14 CDC, with 1474 professionals (83. 3 %). 69.0% of their staff members had the educational level of college or below, 57.9% of them had the primary professional titles even without professional title. No independent Office of Health Emergency had been established in all 14 CDC. All of them had developed their contingency plans, mainly focusing on major infectious diseases and congregative diseases of unknown cause. None of the 14 CDC had joined the development of emergency plans of other departments. The staff members of these 14 CDC could rush to the scene in time. Thel4 CDC were able to monitor the notifiable infectious diseases, sudden public health incidents, serious injuries, basic public health information, health-related factors, population immunity level, quality of laboratory test, and in-hospital deaths of unknown causes, and to analyze the monitoring results regularly. All of them had specialized laboratory workers, all together 14 persons, that were able to isolate and culture the pathogens of major infectious diseases, identify serum, test antibodies, and examine the common toxins. On-scene investigation tools were equipped. No website had been established. However, direct reporting network systems existed and special line telephone systems for counseling were already used. Media communication talents lacked. Training and practice had be conducted. Conclusion A system of CDC has been primarily established in Guangxi. However, the educational and professional levels of their staff members are still low. There is a lack of professional competence and their laboratories are at a low level. Their

  17. Criticality Safety Basics for INL Emergency Responders

    Energy Technology Data Exchange (ETDEWEB)

    Valerie L. Putman


    This document is a modular self-study guide about criticality safety principles for Idaho National Laboratory emergency responders. This guide provides basic criticality safety information for people who, in response to an emergency, might enter an area that contains much fissionable (or fissile) material. The information should help responders understand unique factors that might be important in responding to a criticality accident or in preventing a criticality accident while responding to a different emergency.

    This study guide specifically supplements web-based training for firefighters (0INL1226) and includes information for other Idaho National Laboratory first responders. However, the guide audience also includes other first responders such as radiological control personnel.

    For interested readers, this guide includes clearly marked additional information that will not be included on tests. The additional information includes historical examples (Been there. Done that.), as well as facts and more in-depth information (Did you know …).

    INL criticality safety personnel revise this guide as needed to reflect program changes, user requests, and better information. Revision 0, issued May 2007, established the basic text. Revision 1 incorporates operation, program, and training changes implemented since 2007. Revision 1 increases focus on first responders because later responders are more likely to have more assistance and guidance from facility personnel and subject matter experts. Revision 1 also completely reorganized the training to better emphasize physical concepts behind the criticality controls that help keep emergency responders safe. The changes are based on and consistent with changes made to course 0INL1226.

  18. Responder Technology Alert Monthly (January 2015)

    Energy Technology Data Exchange (ETDEWEB)

    Upton, Jaki F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stein, Steven L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)


    As part of technology foraging for the Responder Technology Alliance, established by the Department of Homeland Science and Technologies First Responders Group, this report summarizes technologies that are relevant in the area of “wearables,” with the potential for use by first responders. The content was collected over the previous month(s) and reproduced from a general Internet search using the term wearables. Additional information is available at the websites provided. This report is not meant to be an exhaustive list nor an endorsement of any technology described herein. Rather, it is meant to provide useful information about current developments in the areas wearable technology.

  19. Responder Technology Alert Monthly (December 2014)

    Energy Technology Data Exchange (ETDEWEB)

    Upton, Jaki F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stein, Steven L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)


    As part of technology foraging for the Responder Technology Alliance, established by the Department of Homeland Science and Technologies First Responders Group, this report summarizes technologies that are relevant in the area of “wearables,” with the potential for use by first responders. The content was collected over the previous month(s) and reproduced from a general Internet search using the term wearables. Additional information is available at the websites provided. This report is not meant to be an exhaustive list nor an endorsement of any technology described herein. Rather, it is meant to provide useful information about current developments in the areas wearable technology.

  20. Porphyria cutanea tarda responding to spirulina


    Pavithran K; Nair P


    A male patient of porphyria cutanea tarda responded to oral spirulina - an alga rich in beta - carotene. The beta - carotene in the spirulina quenches the singlet oxygen which is responsible for the tissue damage in porphyria-associated photosensitivity.

  1. NARAC Dispersion Model Product Integration With RadResponder

    Energy Technology Data Exchange (ETDEWEB)

    Aluzzi, Fernando [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    Work on enhanced cooperation and interoperability of Nuclear Incident Response Teams (NIRT) is a joint effort between DHS/FEMA, DOE/NNSA and EPA. One such effort was the integration between the RadResponder Network, a resource sponsored by FEMA for the management of radiological data during an emergency, and the National Atmospheric Advisory Center (NARAC), a DOE/NNSA modeling resource whose predictions are used to aid radiological emergency preparedness and response. Working together under a FEMA-sponsored project these two radiological response assets developed a capability to read and display plume model prediction results from the NARAC computer system in the RadResponder software tool. As a result of this effort, RadResponder users have been provided with NARAC modeling predictions of contamination areas, radiological dose levels, and protective action areas (e.g., areas warranting worker protection or sheltering/evacuation) to help guide protective action decisions and field monitoring surveys, and gain key situation awareness following a radiological/nuclear accident or incident (e.g., nuclear power plant accident, radiological dispersal device incident, or improvised nuclear detonation incident). This document describes the details of this integration effort.

  2. Excel Center

    Institute of Scientific and Technical Information of China (English)


    Citigroup,one of the World top 500 companies,has now settled in Excel Center,Financial Street. The opening ceremony of Excel Center and the entry ceremony of Citigroup in the center were held on March 31.Government leaders of Xicheng District,the Excel CEO and the heads of Asia-Pacific Region leaders of Citibank all participated in the ceremony.

  3. Responding by exclusion in temporal discrimination tasks. (United States)

    Cippola, Nathália Sabaine; Domeniconi, Camila; Machado, Armando


    Responding by exclusion, one of the most robust phenomena in Experimental Psychology, describes a particular form of responding observed in symbolic, matching-to-sample tasks. Given two comparison stimuli, one experimentally defined and one experimentally undefined, the participant prefers the undefined comparison following an undefined sample. The goal of the present study was to determine whether responding by exclusion could be obtained using samples that varied along a single dimension. Using a double temporal bisection task, 10 university students learned to choose visual comparisons (colored circles) based on the duration of a tone. In tests of exclusion, sample stimuli with new durations were followed by comparison sets that included one previously trained, defined comparison (colored circle) and one previously untrained, undefined comparison (geometric shape). Participants preferred the defined comparisons following the defined samples and the undefined comparisons following the undefined samples, the choice pattern typical of responding by exclusion. The use of samples varying along a single dimension allows us to study the interaction between stimulus generalization gradients and exclusion in the control of conditional responding.

  4. Identifying responders and nonresponders to interferon therapy in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Prosperini L


    Full Text Available Luca Prosperini,1 Marco Capobianco,2 Costanza Giannì31Department of Neurology and Psychiatry, Sapienza University, Rome, Italy; 2Regional Multiple Sclerosis Centre, University Hospital San Luigi Gonzaga, Orbassano, Italy; 3Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USAAbstract: Interferon beta is a well established disease-modifying agent used for relapsing-remitting multiple sclerosis. Despite treatment, a relevant proportion of patients continue to experience clinical (ie, relapses, worsening of disability and magnetic resonance imaging (MRI activity. Early identification of responders and nonresponders to interferon beta is strongly recommended to select patients who need a prompt switch to another disease-modifying agent and to ultimately avoid accumulation of fixed disability over time. Detecting responders and nonresponders to interferon beta can be challenging, mainly because of the lack of a clear and shared clinical definition of response to treatment. Clinical features at the start of treatment should be considered as prognostic factors, but MRI parameters assessed during treatment, such as contrast-enhancing lesions or new T2-hyperintense lesions, may be sensitive markers of response to interferon beta. Quantitative scoring systems derived from a combination of relapses and MRI activity have recently been proposed as practical tools for use in the everyday clinical setting. Blood biomarkers, such as neutralizing antibodies to interferon beta and Myxovirus resistance protein A, provide further useful information for detecting responders and nonresponders to interferon beta. However, since the presence of neutralizing antibodies can only partially explain the nonresponse to interferon beta, biomarkers of interferon beta activity possibly related to the pathogenesis of the disease could represent a future step toward a tailored, long-lasting effective treatment against multiple sclerosis

  5. Mischievous responding in Internet Gaming Disorder research. (United States)

    Przybylski, Andrew K


    The most recent update to the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included Internet Gaming Disorder as a new potential psychiatric condition that merited further scientific study. The present research was conducted in response to the APA Substance-Related Disorders Working Group's research call to estimate the extent to which mischievous responding-a known problematic pattern of participant self-report responding in questionnaires-is relevant to Internet Gaming Disorder research. In line with a registered sampling and analysis plan, findings from two studies (n tot = 11,908) provide clear evidence that mischievous responding is positively associated with the number of Internet Gaming Disorder indicators participants report. Results are discussed in the context of ongoing problem gaming research and the discussion provides recommendations for improving the quality of scientific practice in this area.

  6. Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders. (United States)

    Sarchielli, P; Pini, L A; Zanchin, G; Alberti, A; Maggioni, F; Rossi, C; Floridi, A; Calabresi, P


    The present study was aimed at verifying the clinical characteristics of a typical attack in 20 migraine patients, 10 responders and 10 non-responders to rizatriptan, and at investigating any differences in the levels of neuropeptides of the trigeminovascular or parasympathetic systems [calcitonin gene-related peptide (CGRP), neurokinin A (NKA) and vasoactive intestinal peptide (VIP) measured by radioimmunoassay methods in external jugular blood] between responders and non-responders. In all responders to rizatriptan, pain was unilateral, severe, and pulsating, and in five of them at least one sign suggestive of parasympathetic system activation was recorded. Five patients who were non-responders to rizatriptan referred bilateral and non-pulsating pain, even though severe in most of them. CGRP and NKA levels measured before rizatriptan administration were significantly higher in responders than in non-responders (P rizatriptan responders, detectable VIP levels were found at baseline. One hour after rizatriptan administration, a decrease in CGRP and NKA levels was evident in the external jugular venous blood of rizatriptan responders, and this corresponded to a significant pain relief and alleviation of accompanying symptoms. VIP levels were also significantly reduced at the same time in the five patients with autonomic signs. After rizatriptan administration, CGRP and NKA levels in non-responder patients showed less significant variations at all time points after rizatriptan administration compared with rizatriptan responders. The present study, although carried out on a limited number of patients, supports recent clinical evidence of increased trigeminal activation associated with a better triptan response in migraine patients accompanied by parasympathetic activation in a subgroup of patients with autonomic signs. In contrast, the poor response seems to be correlated with a lesser degree of trigeminal activation, lower variations of trigeminal neuropeptides after

  7. Porphyria cutanea tarda responding to spirulina

    Directory of Open Access Journals (Sweden)

    Pavithran K


    Full Text Available A male patient of porphyria cutanea tarda responded to oral spirulina - an alga rich in beta - carotene. The beta - carotene in the spirulina quenches the singlet oxygen which is responsible for the tissue damage in porphyria-associated photosensitivity.

  8. 42 CFR 93.225 - Respondent. (United States)



  9. Responding to Loneliness: Counseling the Elderly. (United States)

    France, M. Honore


    Describes the development and implementation of a group on "Responding to Loneliness" for the elderly. Focuses on building positive self-esteem; learning social and personal skills; managing stress and anxiety; developing problem-solving strategies; and building a social network. (Author/JAC)

  10. School Principals and Racism: Responding to Aveling (United States)

    Charles, Claire; Mahoney, Caroline; Fox, Brandi; Halse, Christine


    This study responds to Nado Aveling's call in "Anti-racism in Schools: A question of leadership?" ("Discourse: Studies in the Cultural Politics of Education," 2007, 28(1), 69-85) for further investigation into racism in Australian schools. Aveling's interview study concluded that an overwhelming number of school principals…

  11. Responding to Students: Ughs, Awks, and Ahas. (United States)

    Clark, Beverly Lyon


    As writing spreads across the curriculum, faculty members are becoming aware of the extent to which writing is a mode of learning, a way of incorporating new knowledge and of interpreting and analyzing. Effective ways in which a teacher can respond to student writing are discussed. (MLW)

  12. Methods for Handling Missing Secondary Respondent Data (United States)

    Young, Rebekah; Johnson, David


    Secondary respondent data are underutilized because researchers avoid using these data in the presence of substantial missing data. The authors reviewed, evaluated, and tested solutions to this problem. Five strategies of dealing with missing partner data were reviewed: (a) complete case analysis, (b) inverse probability weighting, (c) correction…

  13. Rat embryonic palatal shelves respond to TCDD in organ culture

    Energy Technology Data Exchange (ETDEWEB)

    Abbott, B.D.; Birnbaum, L.S. (National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA))


    TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), a highly toxic environmental contaminant, is teratogenic in mice, inducing cleft palate (CP) and hydronephrosis at doses which are not overtly maternally or embryo toxic. Palatal shelves of embryonic mice respond to TCDD, both in vivo and in organ culture, with altered differentiation of medial epithelial cells. By contrast, in the rat TCDD produces substantial maternal, embryonic, and fetal toxicity, including fetal lethality, with few malformations. In this study the possible effects of maternal toxicity on induction of cleft palate were eliminated by exposure of embryonic rat palatal shelves in organ culture. The shelves were examined for specific TCDD-induced alterations in differentiation of the medial cells. On Gestation Day (GD) 14 or 15 palatal shelves from embryonic F344 rats were placed in organ culture for 2 to 3 days (IMEM:F12 medium, 5% FBS, 0.1% DMSO) containing 0, 1 x 10(-8), 1 x 10(-9), 1 x 10(-10), or 5 x 10(-11) M TCDD. The medial epithelial peridermal cells degenerated on shelves exposed to control media or 5 x 10(-11) M TCDD. Exposure to 10(-10), 10(-9), and 10(-8) M TCDD inhibited this degeneration in 20, 36, and 60% of the shelves, respectively, and was statistically significant at the two highest doses. A normally occurring decrease in (3H)TdR incorporation was inhibited in some GD 15 shelves cultured with 10(-10) and 10(-9) M TCDD. The medial cells of TCDD-exposed shelves continued to express high levels of immunohistochemically detected EGF receptors. The altered differentiation of rat medial epithelium is similar to that reported for TCDD-exposed mouse medial cells in vivo and in vitro. However, in order to obtain these responses, the cultured rat shelves require much higher concentrations of TCDD than the mouse shelves.

  14. Perfil audiométrico de indivíduos expostos ao ruído atendidos no núcleo de saúde ocupacional de um hospital do município de Montes Claros, Minas Gerais Audiometric profile of individuals exposed to noise attended at the center for occupational health for a hospital in the municipality of Montes Claros, Minas Gerais

    Directory of Open Access Journals (Sweden)

    Rejane Noronha Leão


    Full Text Available OBJETIVO: traçar o perfil audiométrico de pacientes expostos a ruído, atendidos no Núcleo de Saúde Ocupacional da Fundação Hospitalar de Montes Claros (Hospital Aroldo Tourinho em Minas Gerais. MÉTODOS: análise de prontuários audiológicos do Núcleo de Saúde Ocupacional da Fundação Hospitalar de Montes Claros/MG de trabalhadores expostos a ruído ocupacional no período de junho a dezembro de 2006. RESULTADOS: a amostra de prontuários caracterizou-se por predominância do sexo masculino (98,3%, com média de 34,7 anos idade. Dos dados obtidos: 37,9% dos trabalhadores não usavam nenhum tipo de protetor auditivo; 19,8% dos trabalhadores foram expostos a um ou mais agente químico; 17% descreveram alguma queixa auditiva; 6,3% usavam algum medicamento; 7,4% citaram doenças prévias; 6,7% relataram deficientes auditivos na família. Identificou-se que 13,2% dos trabalhadores apresentaram perda auditiva na orelha direita (31,8% destas perdas auditivas foram sugestivas de perda auditiva induzida por níveis elevados de pressão sonora e 15,5% na orelha esquerda (36,77% destas perdas auditivas foram sugestivas de perda auditiva induzida por níveis elevados de pressão sonora. CONCLUSÃO: nesta pesquisa houve uma alta prevalência de alterações audiométricas sugestivas de perda auditiva induzida por níveis elevados de pressão sonora, com predomínio maior de perdas auditivas na orelha esquerda. Também houve diferenças significantes em relação à exposição diária dos trabalhadores ao ruído, ao ruído extra-ocupacional e às funções desempenhadas pelos trabalhadores. Além disso, é preocupante o uso insuficiente e inadequado do equipamento de proteção individual auricular por parte dos trabalhadores expostos ao ruído.PURPOSE: to draw the audiometric profile of patients exposed to noise, attended the Center for Occupational Health Foundation's Hospital of Montes Claros (Aroldo Tourinho Hospital in Minas Gerais. METHODS

  15. Distribution center

    Institute of Scientific and Technical Information of China (English)


    Distribution center is a logistics link fulfill physical distribution as its main functionGenerally speaking, it's a large and hiahly automated center destined to receive goods from various plants and suppliers,take orders,fill them efficiently,and deliver goods to customers as quickly as possible.

  16. Behavioral changes in fish exposed to phytoestrogens

    Energy Technology Data Exchange (ETDEWEB)

    Clotfelter, Ethan D. [Department of Biology, Amherst College, Amherst, MA 01002 (United States)]. E-mail:; Rodriguez, Alison C. [Department of Biology, Amherst College, Amherst, MA 01002 (United States)


    We investigated the behavioral effects of exposure to waterborne phytoestrogens in male fighting fish, Betta splendens. Adult fish were exposed to a range of concentrations of genistein, equol, {beta}-sitosterol, and the positive control 17{beta}-estradiol. The following behaviors were measured: spontaneous swimming activity, latency to respond to a perceived intruder (mirror reflection), intensity of aggressive response toward a perceived intruder, probability of constructing a nest in the presence of a female, and the size of the nest constructed. We found few changes in spontaneous swimming activity, the latency to respond to the mirror, and nest size, and modest changes in the probability of constructing a nest. There were significant decreases, however, in the intensity of aggressive behavior toward the mirror following exposure to several concentrations, including environmentally relevant ones, of 17{beta}-estradiol, genistein, and equol. This suggests that phytoestrogen contamination has the potential to significantly affect the behavior of free-living fishes. - Environmentally relevant concentrations of phytoestrogens reduce aggressive behavior in fish.

  17. Exercises of first responder organisations in Austria

    Energy Technology Data Exchange (ETDEWEB)

    Schoenhacker, S. [WIRK.ZONE CBRN Preparedness and Response, Vienna (Austria)


    Although there is no nuclear industry in Austria, there are still many possible scenarios which require proper preparation through exercises. The legislative basis for the interventions of the police are the radiation protection law and the upon based interventions regulation, furthermore the penal law and the law on the transport of dangerous goods. The fire brigade has federal fire fighting laws and internal regulations as a regulatory basis. Exercises of first responder organisations take place once a year at least; the scenarios reflect the actions intended by the regulations. Aeroradiometry is a special technique conducted by the police, while the fire brigade may bring heavy equipment to use. Further improvement of the cooperation of different first responder organisations is a major goal of combined exercises. (orig.)

  18. Mischievous responding in Internet Gaming Disorder research

    Directory of Open Access Journals (Sweden)

    Andrew K. Przybylski


    Full Text Available The most recent update to the American Psychiatric Association’s (APA Diagnostic and Statistical Manual of Mental Disorders (DSM-5 included Internet Gaming Disorder as a new potential psychiatric condition that merited further scientific study. The present research was conducted in response to the APA Substance-Related Disorders Working Group’s research call to estimate the extent to which mischievous responding—a known problematic pattern of participant self-report responding in questionnaires—is relevant to Internet Gaming Disorder research. In line with a registered sampling and analysis plan, findings from two studies (ntot = 11,908 provide clear evidence that mischievous responding is positively associated with the number of Internet Gaming Disorder indicators participants report. Results are discussed in the context of ongoing problem gaming research and the discussion provides recommendations for improving the quality of scientific practice in this area.

  19. Responding to Identity Crime on the Internet

    Directory of Open Access Journals (Sweden)

    Eric Holm


    Full Text Available This paper discusses the unique challenges of responding to identity crime. Identity crime involves the use of personal identification information to perpetrate crimes. As such, identity crime involves using personal and private information to for illegal purposes. In this article, the two significant issues that obstruct responses to this crime are considered. These are first, the reporting of crime, and second the issue of jurisdiction. The paper also presents an exploration of some responses to identity crime.

  20. Challenges to Leadership: Responding to Biological Threats (United States)


    hospitals , doctors, vaccine providers, and others) have mobilized to enhance their readiness, resilience, and capacity to respond. After nearly 10...Influence in Biodefense: The Bio Plum Book, Biosecurity and Bioterrorism: Biodefense Strategy,” Practice and Science 4:2 328 (2004), [available at professionals will often be the first to identify outbreaks. The efforts must also include coordination with the private sector—the hospitals

  1. Mischievous responding in Internet Gaming Disorder research


    Przybylski, Andrew K.


    The most recent update to the American Psychiatric Association’s (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included Internet Gaming Disorder as a new potential psychiatric condition that merited further scientific study. The present research was conducted in response to the APA Substance-Related Disorders Working Group’s research call to estimate the extent to which mischievous responding—a known problematic pattern of participant self-report responding in questionna...

  2. Preventing and responding to medical identity theft. (United States)

    Amori, Geraldine


    Medical identity theft is a crime with two victims: patients and providers. It is easy to commit and lucrative because healthcare record keeping and business interactions are complex and mainly electronic. Patients whose identity has been stolen are vulnerable to both medical error and financial loss. Providers may suffer both reputation loss and financial loss. There are steps to help prevent and to respond appropriately to medical identity theft.

  3. Responding to the Housing and Financial Crises

    DEFF Research Database (Denmark)

    Scanlon, Kathleen; Lunde, Jens; Whitehead, Christine


    The long period of house price growth in markets across the world ended with the US and global financial crisis of 2007/08. The crisis and the consequent recession had profound effects on mortgage market actors – including households, institutions and governments – in most advanced economies....... In particular it reports on a 2009 survey of housing experts from 16 industrialised countries, which concentrated on how each country's mortgage system responded to the crisis and how governments addressed the problems of borrowers....

  4. Elective single blastocyst transfer is more suitable for normal responders than for high responders

    Institute of Scientific and Technical Information of China (English)

    WU Ke-liang; ZHAO Hai-bin; LIU Hui; ZHONG Wan-xia; YU Guan-ling; CHEN Zi-jiang


    Background Embryo quality and receptivity of the endometrium are two factors that determine the results of in vitro fertilization/intra-cytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).There is no consensus of the optimal transfer strategy for normal responders or high responders.The current study aimed to find the optimal transfer strategy for different subgroups of patients.Methods From April 2010 to December 2010,patients who meet the following criteria were included in this study; primary infertility,female age ≤35 years,FSH level on female cycle day 2-3 ≤12 mlU/ml,at least six good quality embryos available on day three.The clinical outcomes using different transfer strategies between normal responders and high responders were reviewed and compared.Results For the normal responders,the clinical pregnancy rate of day three double-embryo transfer (DET) was comparable to that of day five elective single blastocyst transfer (eSBT),64.04% vs.60.33% (P>0.05).For the high responders,the clinical pregnancy rate of day five eSBT was significantly lower than that of day three DET,43.35% vs.57.21% (P<0.05).For the high responders,the rates of clinical pregnancy and implantation in frozen-thawed embryo transfer (FET) cycles were notably higher than in eSBT cycles (64.56% vs.43.35% and 62.11% vs.43.35% respectively) (P<0.05).Conclusions For normal responders,eSBT might be an applicable strategy to reduce multiple pregnancy rates while maintaining acceptable overall pregnancy rates.And in order to reduce multiple pregnancies and increase the chance of pregnancy of high responders,FET may be a preferable strategy.

  5. Agriculture emergencies: a primer for first responders. (United States)

    Gilpen, Johnnie L; Carabin, Hélène; Regens, James L; Burden, Ray W


    Over the past several years, the primary focus of emergency preparedness has been on terrorism, and how a CBRNE event would directly affect human health. Limited emphasis has been placed on the direct (eg, zoonotic infections) and indirect (eg, mental health, financial loss) effects that an agricultural emergency event can have on human health outcomes, and how they relate to emergency preparedness. We critically reviewed the resources and information readily accessible to our target audience, emergency responders; the resources included military and civilian books, personal communications, internet sites, GAO reports, and peer-reviewed journals. Among more than 2,000 bioterrorism-related articles, we found 51 that addressed either agroterrorism and/or veterinary public health: 2 cross-sectional studies, 28 review papers, and 21 commentary papers. In order to properly respond to future agriculture emergencies, emergency response professionals need to understand the nature and implications of the event as well as their roles and responsibilities, but the availability of educational and training opportunities is limited. The results of our review are consistent with the hypothesis that more resources, education, and training opportunities should be available to responders as well as to producers, importers and shippers, international travelers, and the general public. Increased education and training will raise awareness among these groups of the relationship between animal and human health.

  6. Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. (United States)

    Tam, Hok Hei; Melo, Mariane B; Kang, Myungsun; Pelet, Jeisa M; Ruda, Vera M; Foley, Maria H; Hu, Joyce K; Kumari, Sudha; Crampton, Jordan; Baldeon, Alexis D; Sanders, Rogier W; Moore, John P; Crotty, Shane; Langer, Robert; Anderson, Daniel G; Chakraborty, Arup K; Irvine, Darrell J


    Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Using HIV antigens, we found that administering a given total dose of antigen and adjuvant over 1-2 wk through repeated injections or osmotic pumps enhanced humoral responses, with exponentially increasing (exp-inc) dosing profiles eliciting >10-fold increases in antibody production relative to bolus vaccination post prime. Computational modeling of the germinal center response suggested that antigen availability as higher-affinity antibodies evolve enhances antigen capture in lymph nodes. Consistent with these predictions, we found that exp-inc dosing led to prolonged antigen retention in lymph nodes and increased Tfh cell and germinal center B-cell numbers. Thus, regulating the antigen and adjuvant kinetics may enable increased vaccine potency.

  7. Accuracy of discrimination, rate of responding, and resistance to change. (United States)

    Nevin, John A; Milo, Jessica; Odum, Amy L; Shahan, Timothy A


    Pigeons were trained on multiple schedules in which responding on a center key produced matching-to-sample trials according to the same variable-interval 30-s schedules in both components. Matching trials consisted of a vertical or tilted line sample on the center key followed by vertical and tilted comparisons on the side keys. Correct responses to comparison stimuli were reinforced with probability .80 in the rich component and .20 in the lean component. Baseline response rates and matching accuracies generally were higher in the rich component, consistent with previous research. When performance was disrupted by prefeeding, response-independent food during intercomponent intervals, intrusion of a delay between sample and comparison stimuli, or extinction, both response rates and matching accuracies generally decreased. Proportions of baseline response rate were greater in the rich component for all disrupters except delay, which had relatively small and inconsistent effects on response rate. By contrast, delay had large and consistent effects on matching accuracy, and proportions of baseline matching accuracy were greater in the rich component for all four disrupters. The dissociation of response rate and accuracy with delay reflects the localized impact of delay on matching performance. The similarity of the data for response rate and accuracy with prefeeding, response-independent food, and extinction shows that matching performance, like response rate, is more resistant to change in a rich than in a lean component. This result extends resistance to change analyses from the frequency of response emission to the degree of stimulus control, and suggests that the strength of discriminating, like the strength of responding, is positively related to rate of reinforcement.

  8. Test of a Web and Paper Employee Satisfaction Survey: Comparison of Respondents and Non-Respondents

    Directory of Open Access Journals (Sweden)

    Sabina B. Gesell


    Full Text Available This study examined if administering an employee satisfaction survey using the Internet affected the rates or quality of employees’ participation. 644 hospital employees were randomly assigned to complete a satisfaction survey using either a Web survey or a traditional paper measure. Response rates were relatively high across both modes. No evidence for a very large difference in response rates was detected. A plurality of respondents showed no preference for survey mode while the remainder tended to express a preference for the mode they had been randomly assigned to complete in this study. Respondents did not differ from non-respondents by sex, race, or education. Other response differences (such as age and employment status are likely to be a function of the survey topic. Overall, Web and mail respondents did not differ in the level of employee satisfaction reported, the primary outcome being measured.

  9. Support Framework for First Responder Family Members: A Proposed Model for Increasing Responder Effectiveness (United States)

    2009-12-01 Stover, C.W. & Coffman, J. L. (1993). Historic earthquakes, Santa Cruz ( Loma Prieta ...INCREASING RESPONDER EFFECTIVENESS by Brian E. Sturdivant December 2009 Thesis Advisor: Nola Joyce Second Reader: Nadav Morag Approved...Responder Effectiveness 6. AUTHOR(S) Brian E. Sturdivant 5. FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School

  10. "Responding to Climate Change" Course: Research Integration (United States)

    Pfirman, S. L.; Bowman, J. S.


    The "Responding to Climate Change" Barnard/Columbia course integrates current research as well as hands-on research-based activities modified for a classroom environment. The course covers the major response themes of adaptation, mitigation and communication. In the spring of 2015 the course was oriented around Arctic and Antarctic case studies. Each week a different theme is addressed, such as the physical setting, changing ecosystems, governance issues, perspectives of residents and indigenous peoples, geoengineering, commercial interests, security, and health and developmental issues. Frequent guest lectures from thematic experts keep the course grounded in realities and present the students with cutting edge issues. Activities match the weekly theme, for example during the week on Arctic development, students engage with the marine spatial planning simulation Arctic SMARTIC (Strategic Management of Resources in Times of Change) based on research on Arctic sea ice trends and projections coupled with current and projected developmental interests of stakeholders. Created under the Polar Learning and Responding: PoLAR Climate Change Education Partnership (, a complete set of SMARTIC resources is available on line for use by others ( The Responding to Climate Change course is designed to be current and respond to events. For the Arctic case study, students developed proposals for the US State Department as the upcoming Chair of the Arctic Council. Student evaluations indicated that they appreciated the opportunity to connect science with policy and presentation of preliminary proposals in a workshop format was valued as a way to develop and hone their ideas. An additional finding was that students were surprisingly tolerant of technical issues when guest lecturers were linked in via Skype, allowing interaction with thematic experts across the US. Students commented positively on this exposure to

  11. Responding to the Challenge of True Uncertainty

    DEFF Research Database (Denmark)

    Hallin, Carina Antonia; Andersen, Torben Juul

    We construe a conceptual framework for responding effectively to true uncertainty in the business environment. We drill down to the essential micro-foundational capabilities - sensing and seizing of dynamic capabilities - and link them to classical strategic issue management theory with suggestions...... on aggregation of stakeholder sensing and predictions of emergent strategic issues can positively influence the two capabilities and help the firm adapt in the face of uncertainty and unpredictability. Robust measures predicating performance based on information from key stakeholders involved in the firm’s core...

  12. Brain Changes in Responders versus Non-Responders in Chronic Migraine: Markers of Disease Reversal

    Directory of Open Access Journals (Sweden)

    Catherine S Hubbard


    Full Text Available The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥ 15 headache days/month to episodic (EM; < 15 headache days/month migraine following prophylactic treatment with onabotulinumtoxinA. Specifically, we examined whether CM patients responsive to prophylaxis (responders; n = 11, as evidenced by a reversal in disease status (defined by at least a 50% reduction in migraine frequency and < 15 headache days/month, compared to CM patients whose migraine frequency remained unchanged (non-responders; n = 12, showed differences in cortical thickness using surface-based morphometry. We also investigated whether areas showing group differences in cortical thickness displayed altered resting-state functional connectivity (RS-FC using seed-to-voxel analyses. Migraine characteristics measured across groups included disease duration, pain intensity and headache frequency. Patient reports’ of headache frequency over the four weeks prior to (pre-treatment and following (post-treatment prophylaxis were compared (post minus pre and this measure served as the clinical endpoint that determined group assignment. All patients were scanned within two weeks of the post-treatment visit. Results revealed that responders showed significant cortical thickening in the right primary somatosensory cortex (SI and anterior insula, and left superior temporal gyrus and pars opercularis compared to non-responders. In addition, disease duration was negatively correlated with cortical thickness in fronto-parietal and temporo-occipital regions in responders but not non-responders, with the exception of the primary motor cortex (MI that showed the opposite pattern; disease duration was positively associated with MI cortical thickness in responders versus non-responders. Our seed-based RS-FC analyses revealed anti-correlations between the SI seed and lateral occipital (LOC and dorsomedial prefrontal cortices

  13. 75 FR 30306 - Responding To Disruptive Patients (United States)


    ... research, Mental health programs, Nursing homes. Dated: May 26, 2010. Robert C. McFetridge, Director of... Office (163), Veterans Health Administration, Department of Veterans Affairs, 810 Vermont Avenue, NW... domiciliary. We would not include VA nursing homes (also referred to as community living centers) because...

  14. Bats respond to very weak magnetic fields.

    Directory of Open Access Journals (Sweden)

    Lan-Xiang Tian

    Full Text Available How animals, including mammals, can respond to and utilize the direction and intensity of the Earth's magnetic field for orientation and navigation is contentious. In this study, we experimentally tested whether the Chinese Noctule, Nyctalus plancyi (Vespertilionidae can sense magnetic field strengths that were even lower than those of the present-day geomagnetic field. Such field strengths occurred during geomagnetic excursions or polarity reversals and thus may have played an important role in the evolution of a magnetic sense. We found that in a present-day local geomagnetic field, the bats showed a clear preference for positioning themselves at the magnetic north. As the field intensity decreased to only 1/5th of the natural intensity (i.e., 10 μT; the lowest field strength tested here, the bats still responded by positioning themselves at the magnetic north. When the field polarity was artificially reversed, the bats still preferred the new magnetic north, even at the lowest field strength tested (10 μT, despite the fact that the artificial field orientation was opposite to the natural geomagnetic field (P<0.05. Hence, N. plancyi is able to detect the direction of a magnetic field even at 1/5th of the present-day field strength. This high sensitivity to magnetic fields may explain how magnetic orientation could have evolved in bats even as the Earth's magnetic field strength varied and the polarity reversed tens of times over the past fifty million years.

  15. Responding to Indigenous Australian Sexual Assault

    Directory of Open Access Journals (Sweden)

    Janya McCalman


    Full Text Available Indigenous Australians experience a high prevalence of sexual assault, yet a regional sexual assault service found few Indigenous Australians accessed their services. This prompted exploration of how its services might be improved. A resultant systematic search of the literature is reported in this article. Seven electronic databases and seven websites were systematically searched for peer reviewed and gray literature documenting responses to the sexual assault of Indigenous Australians. These publications were then classified by response type and study type. Twenty-three publications met the inclusion criteria. They included studies of legal justice, media, and community-based and mainstream service responses for Indigenous survivors and perpetrators. We located program descriptions, measurement, and descriptive research, but no intervention studies. There is currently insufficient evidence to confidently prescribe what works to effectively respond to Indigenous Australian sexual assault. The study revealed an urgent need for researchers, Indigenous communities, and services to work together to develop the evidence base.

  16. Hazard perception in emergency medical service responders. (United States)

    Johnston, K A; Scialfa, C T


    The perception of on-road hazards is critically important to emergency medical services (EMS) professionals, the patients they transport and the general public. This study compared hazard perception in EMS and civilian drivers of similar age and personal driving experience. Twenty-nine EMS professionals and 24 non-professional drivers were given a dynamic hazard perception test (HPT). The EMS group demonstrated an advantage in HPT that was independent of simple reaction time, another indication of the validity of the test. These results are also consistent with the view that professional driving experience results in changes in the ability to identify and respond to on-road hazards. Directions for future research include the development of a profession-specific hazard perception tool for both assessment and training purposes.

  17. Biodetection Technologies for First Responders: 2014 Edition

    Energy Technology Data Exchange (ETDEWEB)

    Ozanich, Richard M.; Baird, Cheryl L.; Bartholomew, Rachel A.; Colburn, Heather A.; Straub, Tim M.; Bruckner-Lea, Cindy J.


    This report summarizes commercially-available, hand-portable technologies that can be used by first responders in the field. This is not meant to be an exhaustive list, nor an endorsement of any technology described herein. Rather, this report is meant to provide useful information about available technologies to help end-users make informed decisions about biodetection technology procurement and use. Information listed in this report is primarily vendor-provided; however, where possible it has been supplemented with additional information obtained from publications, reports, and websites. Manufacturers were given the chance to review summaries of their technologies from August through November 2013 to verify the accuracy of technical specifications, available references, and pricing.

  18. Crowdsourced Decision Support for Emergency Responders (United States)


    the GMU campus: a large concert at the Patriot Center, and a speech by a fictional controversial author named Simon Pierce taking place at the...Separately, the websites of the County and GMU were hacked by a fictional terrorist group called the Anti-Pierce Group. They defaced the websites and...Internet. Interaction was limited to laptops. Support for mobile devices would increase realism and improve student access, but required too much

  19. NASA New England Outreach Center (United States)


    The NASA New England Outreach Center in Nashua, New Hampshire was established to serve as a catalyst for heightening regional business awareness of NASA procurement, technology and commercialization opportunities. Emphasis is placed on small business participation, with the highest priority given to small disadvantaged businesses, women-owned businesses, HUBZone businesses, service disabled veteran owned businesses, and historically black colleges and universities and minority institutions. The Center assists firms and organizations to understand NASA requirements and to develop strategies to capture NASA related procurement and technology opportunities. The establishment of the NASA Outreach Center serves to stimulate business in a historically underserved area. NASA direct business awards have traditionally been highly present in the West, Midwest, South, and Southeast areas of the United States. The Center guides and assists businesses and organizations in the northeast to target opportunities within NASA and its prime contractors and capture business and technology opportunities. The Center employs an array of technology access, one-on-one meetings, seminars, site visits, and targeted conferences to acquaint Northeast firms and organizations with representatives from NASA and its prime contractors to learn about and discuss opportunities to do business and access the inventory of NASA technology. This stimulus of interaction also provides firms and organizations the opportunity to propose the use of their developed technology and ideas for current and future requirements at NASA. The Center provides a complement to the NASA Northeast Regional Technology Transfer Center in developing prospects for commercialization of NASA technology. In addition, the Center responds to local requests for assistance and NASA material and documents, and is available to address immediate concerns and needs in assessing opportunities, timely support to interact with NASA Centers on

  20. Responding to JCAHO standards: everybody's business. (United States)

    Fletcher, John C


    At this stage, JCAHO [Joint Commission on Accreditation of Healthcare Organizations] site visitors simply want to know how the institution plans to respond to the organization ethics standard. In the near future, however, they will expect data on how ethical issues have been addressed that faced the organization in marketing, billing, managed care contracts, and so on. Pointing to an organizational code of ethics will not be enough. Examples of leadership utilizing the processes of the committee or an appropriate consultant or group, to the ends of education, policy studies, and consultation on specific choices will meet the standard. Organizations that evade or choose not to supply data along these lines will presumably be negatively evaluated. Noncompliance presumably means a risk to accreditation. The message to the clinical ethics committee is a serious one. We must engage in the regional planning and organization needed to provide education and training needed by ethics committees for these two tasks, within the constraints of realism, that is, that these are requirements that are primarily expected of the clinical community and the organizations that provide care to patients.

  1. Harbour porpoises respond to climate change. (United States)

    Heide-Jørgensen, Mads Peter; Iversen, Maria; Nielsen, Nynne Hjort; Lockyer, Christina; Stern, Harry; Ribergaard, Mads Hvid


    The effects of climate change on marine ecosystems and in particular on marine top predators are difficult to assess due to, among other things, spatial variability, and lack of clear delineation of marine habitats. The banks of West Greenland are located in a climate sensitive area and are likely to elicit pronounced responses to oceanographic changes in the North Atlantic. The recent increase in sea temperatures on the banks of West Greenland has had cascading effects on sea ice coverage, residency of top predators, and abundance of important prey species like Atlantic cod (Gadus morhua). Here, we report on the response of one of the top predators in West Greenland; the harbour porpoise (Phocoena phocoena). The porpoises depend on locating high densities of prey species with high nutritive value and they have apparently responded to the general warming on the banks of West Greenland by longer residence times, increased consumption of Atlantic cod resulting in improved body condition in the form of larger fat deposits in blubber, compared to the situation during a cold period in the 1990s. This is one of the few examples of a measurable effect of climate change on a marine mammal population.

  2. Blue whales respond to anthropogenic noise.

    Directory of Open Access Journals (Sweden)

    Mariana L Melcón

    Full Text Available Anthropogenic noise may significantly impact exposed marine mammals. This work studied the vocalization response of endangered blue whales to anthropogenic noise sources in the mid-frequency range using passive acoustic monitoring in the Southern California Bight. Blue whales were less likely to produce calls when mid-frequency active sonar was present. This reduction was more pronounced when the sonar source was closer to the animal, at higher sound levels. The animals were equally likely to stop calling at any time of day, showing no diel pattern in their sensitivity to sonar. Conversely, the likelihood of whales emitting calls increased when ship sounds were nearby. Whales did not show a differential response to ship noise as a function of the time of the day either. These results demonstrate that anthropogenic noise, even at frequencies well above the blue whales' sound production range, has a strong probability of eliciting changes in vocal behavior. The long-term implications of disruption in call production to blue whale foraging and other behaviors are currently not well understood.

  3. Blue whales respond to anthropogenic noise. (United States)

    Melcón, Mariana L; Cummins, Amanda J; Kerosky, Sara M; Roche, Lauren K; Wiggins, Sean M; Hildebrand, John A


    Anthropogenic noise may significantly impact exposed marine mammals. This work studied the vocalization response of endangered blue whales to anthropogenic noise sources in the mid-frequency range using passive acoustic monitoring in the Southern California Bight. Blue whales were less likely to produce calls when mid-frequency active sonar was present. This reduction was more pronounced when the sonar source was closer to the animal, at higher sound levels. The animals were equally likely to stop calling at any time of day, showing no diel pattern in their sensitivity to sonar. Conversely, the likelihood of whales emitting calls increased when ship sounds were nearby. Whales did not show a differential response to ship noise as a function of the time of the day either. These results demonstrate that anthropogenic noise, even at frequencies well above the blue whales' sound production range, has a strong probability of eliciting changes in vocal behavior. The long-term implications of disruption in call production to blue whale foraging and other behaviors are currently not well understood.

  4. 78 FR 72666 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting...: Notice of Open Public Meeting of the First Responder Network Authority. SUMMARY: The Board of the First Responder Network Authority (FirstNet) will convene open public meetings of the Board Committees on...

  5. 78 FR 57843 - First Responder Network Authority Board Meeting (United States)


    ... Washington, DC See First Responder Network Authority Board Meeting, Notice of Open Public Meetings, 77 FR... National Telecommunications and Information Administration First Responder Network Authority Board Meeting... (NTIA) will convene an open public meeting of the Board of the First Responder Network Authority...

  6. 31 CFR 560.704 - Presentation responding to prepenalty notice. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Presentation responding to prepenalty... Penalties § 560.704 Presentation responding to prepenalty notice. (a) Time within which to respond. The... presentation to the Director. (b) Form and contents of the written presentation. The written presentation...

  7. 31 CFR 535.703 - Presentation responding to prepenalty notice. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Presentation responding to prepenalty... Penalties § 535.703 Presentation responding to prepenalty notice. (a) Time within which to respond. The... presentation to the Director. (b) Form and contents of written presentation. The written presentation need...

  8. 31 CFR 575.703 - Presentation responding to prepenalty notice. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Presentation responding to prepenalty... Penalties § 575.703 Presentation responding to prepenalty notice. (a) Time within which to respond. The... presentation to the Director. (b) Form and contents of written presentation. The written presentation need...

  9. 31 CFR 595.703 - Presentation responding to prepenalty notice. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Presentation responding to prepenalty... Penalties § 595.703 Presentation responding to prepenalty notice. (a) Time within which to respond. The... presentation to the Director of the Office of Foreign Assets Control. (b) Form and contents of...

  10. 78 FR 38014 - First Responder Network Authority Board Special Meeting (United States)


    .... ACTION: Notice of Public Meeting of the First Responder Network Authority. SUMMARY: The Board of the First Responder Network Authority (FirstNet) will hold a Special Meeting via telephone conference... National Telecommunications and Information Administration First Responder Network Authority Board...

  11. 78 FR 63168 - First Responder Network Authority Board Special Meeting (United States)


    .... ACTION: Notice of Public Meeting of the First Responder Network Authority. SUMMARY: The Board of the First Responder Network Authority (FirstNet) will hold a Special Meeting via telephone conference... National Telecommunications and Information Administration First Responder Network Authority Board...

  12. 78 FR 54241 - First Responder Network Authority Board Special Meeting (United States)


    .... ACTION: Notice of Public Meeting of the First Responder Network Authority. SUMMARY: The Board of the First Responder Network Authority (FirstNet) will hold a Special Meeting via telephone conference... National Telecommunications and Information Administration First Responder Network Authority Board...

  13. Centering research

    DEFF Research Database (Denmark)

    Katan, Lina Hauge; Baarts, Charlotte

    and collected 24 portfolios in which students reflect auto-ethnographically on their educational practices. Analyzing this qualitative material, we explore how researchers and students respectively read and write to develop and advance their thinking in those learning processes that the two groups fundamentally...... share as the common aim of both research and education. Despite some similarities, we find that how the two groups engage in and benefit from reading and writing diverges significantly. Thus we have even more reason to believe that centering practice-based teaching on these aspects of research is a good...

  14. Fast-responder: Rapid mobile-phone access to recent remote sensing imagery for first responders (United States)

    Talbot, L. M.; Talbot, B. G.

    We introduce Fast-Responder, a novel prototype data-dissemination application and architecture concept to rapidly deliver remote sensing imagery to smartphones to enable situational awareness. The architecture implements a Fast-Earth image caching system on the phone and interacts with a Fast-Earth server. Prototype evaluation successfully demonstrated that National Guard users could select a location, download multiple remote sensing images, and flicker between images, all in less than a minute on a 3G mobile commercial link. The Fast-Responder architecture is a significant advance that is designed to meet the needs of mobile users, such as National Guard response units, to rapidly access information during a crisis, such as a natural or man-made disaster. This paper focuses on the architecture design and advanced user interface concepts for small-screens for highly active mobile users. Novel Fast-Responder concepts can also enable rapid dissemination and evaluation of imagery on the desktop, opening new technology horizons for both desktop and mobile users.

  15. Genomic damage in children accidentally exposed to ionizing radiation

    DEFF Research Database (Denmark)

    Fucic, A; Brunborg, G; Lasan, R


    During the last decade, our knowledge of the mechanisms by which children respond to exposures to physical and chemical agents present in the environment, has significantly increased. Results of recent projects and programmes focused on children's health underline a specific vulnerability...... of children to environmental genotoxicants. Environmental research on children predominantly investigates the health effects of air pollution while effects from radiation exposure deserve more attention. The main sources of knowledge on genome damage of children exposed to radiation are studies performed...... after the Chernobyl nuclear plant accident in 1986. The present review presents and discusses data collected from papers analyzing genome damage in children environmentally exposed to ionizing radiation. Overall, the evidence from the studies conducted following the Chernobyl accident, nuclear tests...

  16. [Theater in Brazilian science museums and centers]. (United States)

    Moreira, Leonardo Maciel; Marandino, Martha


    This qualitative research, based on a descriptive and exploratory study, examines how theater is used as a science communication strategy by Brazilian science museums and centers. Data was collected through a survey emailed to 24 Brazilian institutions identified as science museums and centers. Content analysis was performed, using cross-sectional thematic analysis. It was found that respondents' activities could be classified as approaching theater as an educational support.

  17. Rich media streaming for just-in-time training of first responders (United States)

    Bandera, Cesar; Marsico, Michael


    The diversity of first responders and of asymmetric threats precludes the effectiveness of any single training syllabus. Just-in-time training (JITT) addresses this variability, but requires training content to be quickly tailored to the subject (the threat), the learner (the responder), and the infrastructure (the C2 chain from DHS to the responder"s equipment). We present a distributed system for personalized just-in-time training of first responders. The authoring and delivery of interactive rich media and simulations, and the integration of JITT with C2 centers, are demonstrated. Live and archived video, imagery, 2-D and 3-D models, and simulations are autonomously (1) aggregated from object-oriented databases into SCORM-compliant objects, (2) tailored to the individual learner"s training history, preferences, connectivity and computing platform (from workstations to wireless PDAs), (3) conveyed as secure and reliable MPEG-4 compliant streams with data rights management, and (4) rendered as interactive high-definition rich media that promotes knowledge retention and the refinement of learner skills without the need of special hardware. We review the object-oriented implications of SCORM and the higher level profiles of the MPEG-4 standard, and show how JITT can be integrated into - and improve the ROI of - existing training infrastructures, including COTS content authoring tools, LMS/CMS, man-in-the-loop simulators, and legacy content. Lastly, we compare the audiovisual quality of different streaming platforms under varying connectivity conditions.

  18. Behavioral evaluation of workers exposed to mixtures of organic solvents

    Energy Technology Data Exchange (ETDEWEB)

    Maizlish, N.A.; Langolf, G.D.; Whitehead, L.W.; Fine, L.J.; Albers, J.W.; Goldberg, J.; Smith, P.


    Reports from Scandinavia have suggested behavioral impairment among long term workers exposed to solvents below regulatory standards. A cross sectional study of behavioral performance was conducted among printers and spray painters exposed to mixtures of organic solvents to replicate the Scandinavian studies and to examine dose-response relationships. Eligible subjects consisted of 640 hourly workers from four midwestern United States companies. Of these, 269 responded to requests to participate and 240 were selected for study based on restrictions for age, sex, education, and other potentially confounding variables. The subjects tested had been employed on average for six years. Each subject completed an occupational history, underwent a medical examination, and completed a battery of behavioural tests. These included the Fitts law psychomotor task, the Stroop color-word test, the Sternberg short term memory scanning test, the short term memory span test, and the continuous recognition memory test. Solvent exposure for each subject was defined as an exposed or non-exposed category based on a plant industrial hygiene walk-through and the concentration of solvents based on an analysis of full shift personal air samples by gas chromatography. The first definition was used to maintain consistency with Scandinavian studies, but the second was considered to be more accurate. The average full shift solvent concentration was 302 ppm for the printing plant workers and 6-13 ppm for the workers at other plants. Isopropanol and hexane were the major components, compared with toluene in Scandinavian studies.

  19. Vital analysis: annotating sensed physiological signals with the stress levels of first responders in action. (United States)

    Gomes, P; Kaiseler, M; Queirós, C; Oliveira, M; Lopes, B; Coimbra, M


    First responders such as firefighters are exposed to extreme stress and fatigue situations during their work routines. It is thus desirable to monitor their health using wearable sensing but this is a complex and still unsolved research challenge that requires large amounts of properly annotated physiological signals data. In this paper we show that the information gathered by our Vital Analysis Framework can support the annotation of these vital signals with the stress levels perceived by the target user, confirmed by the analysis of more than 4600 hours of data collected from real firefighters in action, including 717 answers to event questionnaires from a total of 454 different events.

  20. CIRUN: Climate Information Responding to User Needs (United States)

    Busalacchi, A. J.


    The Earth System will experience real climate change over the next 50 years, exceeding the scope of natural climate variability. A paramount question facing society is how to adapt to this certainty of climate variability and change. In response, OSTP and NOAA are considering how comprehensive climate services would best inform decisions about adaptation. Similarly, NASA is considering the optimal configuration of the next generation of Earth, environmental, and climate observations to be deployed over the coming 10-20 years. Moreover, much of the added-value information for specific climate-related decisions will be provided by private, academic and non-governmental organizations. In this context, over the past several years the University of Maryland has established the CIRUN (Climate Information: Responding to User Needs) initiative to identify the nature of national needs for climate information and services from a decision support perspective. To date, CIRUN has brought together decisionmakers in a number of sectors to help understand their perspectives on climate with the goal of improving the usefulness of climate information, observations and prediction products to specific user communities. CIRUN began with a major workshop in October 2007 that convened 430 participants in agriculture, parks and recreation, terrestrial ecosystems, insurance/investment, energy, national security, state/local/municipal, water, human health, commerce and manufacturing, transportation, and coastal/marine sectors. Plenary speakers such as Norman Augustine, R. James Woolsey, James Mahoney, and former Senator Joseph Tydings, breakout panel sessions, and participants provided input based on the following: - How would you characterize the exposure or vulnerability to climate variability or change impacting your organization? - Does climate variability and/or change currently factor into your organization's objectives or operations? - Are any of your existing plans being affected by

  1. 76 FR 71604 - Kamal Tiwari, M.D.; Pain Management and Surgery Center of Southern Indiana; Decision and Order (United States)


    ... Enforcement Administration Kamal Tiwari, M.D.; Pain Management and Surgery Center of Southern Indiana... Pain Management and Surgery Center (Respondent PMSC), holder of DEA Certificate of Registration... to Respondent Pain Management and Surgery Center of Southern Indiana, be, and they hereby...

  2. Web-Based Instruction and Learning: Responding to K-14 Customer Needs (United States)

    McCarthy, Marianne; Grabowski, Barbara; Koszalka, Tiffany; Peck, Christa


    A follow-up working conference was held at Lewis Research Center (now Glenn Research Center) on September 23-25, 1997, to continue discussing issues related to the development of Web-based education materials for the K-14 community. The conference continued the collaboration among the NASA aerospace technology Centers (Ames, Dryden, Langley, and Lewis [now Glenn]), NASA Headquarters, the University of Idaho and the Pennsylvania State University. The conference consisted of presentations by the Aeronautics Cooperative Agreement teams, and working sessions that addressed issues related to the conference theme, responding to the K-14 customers needs. The group identified the most significant issues by consensus. The issues addressed were: classroom access, World Wide Web resources, teacher training, different teaching and learning styles, interactivity, and education standards. The working sessions produced observations and recommendations in each of these areas in order to work toward the goal of making NASA sponsored Web-based educational resources useful to teachers and students.

  3. Corifollitropin alfa followed by rFSH in a GnRH antagonist protocol for poor ovarian responder patients

    DEFF Research Database (Denmark)

    Polyzos, Nikolaos P; Devos, Michel; Humaidan, Peter;


    OBJECTIVE: To identify whether women with poor ovarian response may benefit from treatment with corifollitropin alfa in a GnRH antagonist protocol. DESIGN: Retrospective pilot study. SETTING: University-based tertiary care center. PATIENT(S): Poor ovarian responders fulfilling the Bologna criteria...... developed by European Society for Human Reproduction and Embryology Consensus Group. INTERVENTION(S): Corifollitropin alfa (150 μg) followed by 300 IU rFSH in a GnRH antagonist protocol. MAIN OUTCOME MEASURE(S): Endocrinologic profile and ongoing pregnancy rates. RESULT(S): Among 43 women treated...... compared with a cohort of patients treated during 2011 with the standard protocol for poor responders in our center (short agonist-hMG) (7% vs. 6.3%). CONCLUSION(S): Treatment of poor ovarian responders, as described by the Bologna criteria, with corifollitropin alfa in a GnRH antagonist protocol results...

  4. Habituation of salivation and motivated responding for food in children. (United States)

    Epstein, Leonard H; Saad, Frances G; Handley, Elizabeth A; Roemmich, James N; Hawk, Larry W; McSweeney, Frances K


    Repeated presentation of food cues results in habituation in adults, as demonstrated by a decrement in salivary responding that is reversed by presenting a new food cue in adults. Food reinforced behavior in animals shows the same pattern of responding, with a decrease in responding to obtain the food, followed by a recovery of responding when a new food is presented. The present study assessed whether children would show the same pattern of a decrement of food reinforced responding followed by recovery of responding when a new food is presented for both salivation and food reinforcement tasks. Subjects were assigned to one of two groups that differed in the trial that the new food stimulus was presented to ensure recovery was specific to the introduction of the new food stimulus. In the salivation task, subjects were provided repeated olfactory presentations of a cheeseburger with apple pie as the new food stimulus, while in the food reinforcement task subjects worked for the opportunity to consume a cheeseburger, followed by the opportunity to work for consumption of apple pie. Subjects in both groups showed a decrement in salivary and food reinforced responding to repeated food cues followed by immediate recovery of responding on the trial when a new food was presented. Subjects increased their energy intake by over 30% in the food reinforcement task when a new food was presented. These results are consistent with the general process theory of motivation that suggests that changes in food reinforced responding may be due in part to habituation.

  5. Exposing cloud computing as a failure

    Directory of Open Access Journals (Sweden)

    Vikas Kumar Chauhan


    Full Text Available Cloud Computing is considered to be the architecture of the IT enterprise for the next generation. With an ever-growing list of cloud computing service providers, the decision for enterprises on how far to leverage computing platforms and with whom is quite complex. Cloud Computing has replaced the traditional solutions, where the IT services are under proper physical, logical and personnel controls by moving the application software and databases to the large data centers. But there the management of the data and services may not be fully trustworthy and is bound to failure. This exclusive aspect of cloud computing, however, causes many new challenges like data failure and disasters. In this paper, we have focused on exposing the various aspects of failure in cloud computing, which has always been an important aspect of the safety and consistency of data and quality of service. We characterize the problems and the impact of failure and disasters of cloud computing with few examples. In addition, and equally importantly, we describe how the complexity of the failure increases with the complexity of the system.

  6. Dopamine agonist and antagonist responders as related to types of nicotine craving and facets of extraversion. (United States)

    Reuter, Martin; Netter, Petra; Toll, Claudia; Hennig, Juergen


    The role of dopamine (DA) in drug seeking behavior has been a matter of debate in the literature: One theory claims that DA triggers incentive motivational behavior, the other one favors the idea that DA itself is the rewarding property induced by the positive stimuli. The present experiment tries to contribute to a solution of the controversy by the approach of relating DA-associated motivational behavior to constellations of hormone response to a DA agonistic and DA antagonistic challenge performed in the same subjects and by relating their responses to different aspects of personality and smoking motivation. DA agonist (lisuride = LIS), DA antagonist (fluphenazine = FLU), and placebo (P) were applied to 36 male smokers who were deprived from smoking for 3.5 h in a balanced crossover design. Cigarette craving and prolactin (PRL) responses to the drugs were compared under the three pharmacological conditions and related to personality and smoking motivation. Results showed that PRL responder types to LIS and FLU, defined as differences from respective placebo values, emerged as pure agonist or antagonist responders in two-thirds of the cases and as mixed types in one-third. PRL-LIS responders developed more craving in the LIS condition and PRL-FLU responders when exposed to FLU. Furthermore, the first group scored high on the sensation seeking scale (SSS), which related to the concept of incentive motivation and the FLU responders high on extraversion and smoking motivation for stimulating purposes suggesting the endeavor to replace DA. Thus, evidence for the validity of both theories is proven.

  7. Risks to emergency medical responders at terrorist incidents: a narrative review of the medical literature. (United States)

    Thompson, Julian; Rehn, Marius; Lossius, Hans Morten; Lockey, David


    As the threat of international terrorism rises, there is an increasing requirement to provide evidence-based information and training for the emergency personnel who will respond to terrorist incidents. Current major incident training advises that emergency responders prioritize their own personal safety above that of the 'scene and survivors'. However, there is limited information available on the nature of these threats and how they may be accurately evaluated. This study reviews the published medical literature to identify the hazards experienced by emergency responders who have attended previous terrorist incidents. A PubMed literature search identified 10,894 articles on the subject of 'terrorism', and there was a dramatic increase in publications after the 9/11 attacks in 2001. There is heterogeneity in the focus and quality of this literature, and 307 articles addressing the subject of scene safety were assessed for information regarding the threats encountered at terrorist incidents. These articles demonstrate that emergency responders have been exposed to both direct terrorist threats and environmental scene hazards, including airborne particles, structural collapse, fire, and psychological stress. The emphasis of training and preparedness for terrorist incidents has been primarily on the direct threats, but the published literature suggests that the dominant causes of mortality and morbidity in responders after such incidents are the indirect environmental hazards. If the medical response to terrorist incidents is to be based on evidence rather than anecdote, analysis of the current literature should be incorporated into major incident training, and consistent collection of key data from future incidents is required.

  8. Advances in treating exposed fractures. (United States)

    Nogueira Giglio, Pedro; Fogaça Cristante, Alexandre; Ricardo Pécora, José; Partezani Helito, Camilo; Lei Munhoz Lima, Ana Lucia; Dos Santos Silva, Jorge


    The management of exposed fractures has been discussed since ancient times and remains of great interest to present-day orthopedics and traumatology. These injuries are still a challenge. Infection and nonunion are feared complications. Aspects of the diagnosis, classification and initial management are discussed here. Early administration of antibiotics, surgical cleaning and meticulous debridement are essential. The systemic conditions of patients with multiple trauma and the local conditions of the limb affected need to be taken into consideration. Early skeletal stabilization is necessary. Definitive fixation should be considered when possible and provisional fixation methods should be used when necessary. Early closure should be the aim, and flaps can be used for this purpose.

  9. Quenched Reinforcement Exposed to Fire

    DEFF Research Database (Denmark)

    Hertz, Kristian Dahl


    Idealized data are derived for the tensile strength of quenched and tempered prestressing steel and of quenched and self-tempered reinforcing bars for fire safety design. 0.2% stresses are derived as a function of the maximum temperature and in addition, 2.0% stresses are provided. A strain of 2.......0% is seldom found in “slack” (not prestressed) reinforcement, but 2.0% stresses might be relevant for reinforcement in T shaped cross sections and for prestressed structures, where large strains can be applied. All data are provided in a “HOT” condition during a fire and in a “COLD” condition after a fire....... The COLD condition is relevant for analyses of residual load bearing capacity of a structure after a fire exposure. It is also relevant for analyses of concrete structures exposed to fully developed fire courses. The reason is that compression zones of concrete are always the weakest in the cooling phase...

  10. The trigonometric responder approach: a new method for detecting responders to pharmacological or experimental challenges. (United States)

    Reuter, M; Siegmund, A; Netter, P


    The paper presents a newly developed response measure that is particularly suitable for the evaluation of pharmacokinetic data. This method is based on trigonometric considerations, defining a hormone response as the difference between the angle of the slope of the curve before and after drug intake. In addition, the size of this difference is compared to the difference obtained in placebo conditions. In this way, the trigonometric response measure overcomes one of the most problematic shortcomings of the 'area under the curve' (AUC) approach, the problem of the initial value. We will present the mathematical background of the trigonometric method and demonstrate its usefulness by evaluating empirical data (a pharmacological challenge test using the dopamine agonist lisuride) and comparing it to classical AUC measures. This has been achieved by contrasting both approaches with responder definitions according to binary time series analysis and the peak value of the curve.

  11. Mississippi Technology Transfer Center (United States)


    The Mississippi Technology Transfer Center at the John C. Stennis Space Center in Hancock County, Miss., was officially dedicated in 1987. The center is home to several state agencies as well as the Center For Higher Learning.

  12. A case of lichen planus pigmentosus that was recalcitrant to topical treatment responding to pigment laser treatment. (United States)

    Han, Xiuhui Debra; Goh, Chee Leok


    Lichen planus pigmentosus is a rare variant of lichen planus for which no effective treatment is currently available. Patients usually present with hyperpigmented, dark brown macules on sun-exposed areas or flexural folds. Here we describe a 50-year-old Chinese woman who had biopsy-confirmed lichen planus pigmentosus that was recalcitrant to a variety of topical treatments, but responded to treatment with a pigment laser.

  13. Transportation Technical Environmental Information Center index

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, C.A.; Foley, J.T.


    In an effort to determine the environmental intensities to which energy materials in transit may be exposed, a ''Data Center'' of technical environmental information has been established by Sandia Laboratories, Division 5522, for the DOE Division of Environmental Control Technology. An index is presented which can be used to request data of interest.

  14. 78 FR 5422 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting... public meeting of the Board of the First Responder Network Authority (FirstNet) to be held on February 12... Time. ADDRESSES: Board members will meet at the National Institute of Standards and Technology...

  15. 77 FR 67342 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting... (NTIA) will convene open public meetings of the Board of the First Responder Network Authority (FirstNet.... ADDRESSES: For the meetings in Washington, DC, Board members will meet in the Secretary's Conference...

  16. 78 FR 72667 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting...: Notice of Open Public Meeting of the First Responder Network Authority. SUMMARY: The Board of the First... Board meeting will be held on December 17, 2013, from 9:00 a.m. to 12:00 p.m., Mountain Standard...

  17. 78 FR 20619 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting... (NTIA) will convene an open public meeting of the Board of the First Responder Network Authority (First... Time. ADDRESSES: Board members will meet in the Cotton II Room at the Westin Westminster Hotel,...

  18. Progesterone elevation does not compromise pregnancy rates in high responders

    DEFF Research Database (Denmark)

    Griesinger, Georg; Mannaerts, Bernadette; Andersen, Claus Yding


    To compare the impact of elevated P during the late follicular phase on the chance of pregnancy in low, normal, and high responders.......To compare the impact of elevated P during the late follicular phase on the chance of pregnancy in low, normal, and high responders....

  19. 31 CFR 585.703 - Presentation responding to prepenalty notice. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Presentation responding to prepenalty... SANCTIONS REGULATIONS Penalties § 585.703 Presentation responding to prepenalty notice. (a) Time within... to make a written presentation to the Director. (b) Form and contents of written presentation....

  20. Collaboration and interaction of first responders with the general public

    NARCIS (Netherlands)

    Emmerik, M. van; Dinesen, C.; Rijk, R. van; Bird, M.; Wester, M.; Hansen, L.J.; Vinther-Larsen, L.; Padron, C.; Boswinkel, R.; Ven, J. van de


    There is an increased focus on the need for collaboration between first responders and the general public. This type of collaboration requires soft skills that are not necessarily included in more traditional command and control trainings for first responders. Learning to collaborate with the genera

  1. Meta-Analysis and Inadequate Responders to Intervention: A Reply (United States)

    Swanson, H. Lee


    A meta-analysis by Tran, Sanchez, Arellano, and Swanson (2011) of the published RTI literature found that the magnitude of effect size (ES) between responders and low responders at posttest was significantly moderated by the pretest ES and the type of dependent measure administered, whereas no significant moderating effects were found in the mixed…

  2. Understanding and Responding to Adolescent Girls' Online Cruelty (United States)

    Sokal, Laura


    Many school counsellors have identified "cyber-bullying" among adolescent girls as a growing concern. In order to respond to this issue, this article begins with a new model of cyber-communications from the unique perspective of adolescent girls. Next, it explores the limitations of responding to this model, based on current understandings of…

  3. Training Law Enforcement Officials on Responding to Equine Calls (United States)

    Anderson, Kathleen P.; Stauffer, Gary; Stauffer, Monte; Anderson, Doug; Biodrowski, Kristie


    The occurrence of equine abuse/neglect cases is an ongoing issue. However, officials responding to equine cases are rarely experienced in handling horses. Therefore, workshops teaching basic horse husbandry were offered to better equip and prepare officials to respond to equine cases. Trainings consisted of both classroom and hands-on sessions.…

  4. Design Effects in Web Surveys : Comparing Trained and Fresh Respondents

    NARCIS (Netherlands)

    Toepoel, V.; Das, J.W.M.; van Soest, A.H.O.


    In this paper we investigate whether there are differences in design effects between trained and fresh respondents. In three experiments, we varied the number of items on a screen, the choice of response categories, and the layout of a five point rating scale. We find that trained respondents are mo

  5. Control for occupationally exposed personnels

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, Hiroyuki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Momose, Takuma


    The present status of the technology for the measurement of personnel exposure dose was reviewed based on the basic concept of ICRP Recommendation on new assessment of exposure dose. The personnel dosimeter which has been mostly used by occupationally exposed personnels in Japan is film badge or thermoluminescence dosimeter. Now, photoluminescent glass dosimeter has been paid attention because pulse excitation method by UV laser has been developed. Measurement at an accuracy of 0.1 mSv or more became possible by using this dosimeter at present. In addition, characteristic studies for practical application of electronic, photostimulated luminescence and neutron dosimeters are progressing now. Revision of kinetic model of in vivo metabolism of radioactive substances is progressing based on the recent findings since ICRP Recommendation in 1990. Monitoring an individual internal exposure is made by two methods; direct measurement of the radiation emitted from the body and indirect one by radioanalysis of excretes etc. The latter is inferior to the former in respect of the accuracy of dose assessment, but the direct method is more suitable to detect a little amount of radioactive substance incorporated because of its high sensitivity. In future, it is needed to provide a considerable number of whole body counters against a large-scale nuclear accident. (M.N.)

  6. The hidden price of repeated traumatic exposure: Different cognitive deficits in different first-responders

    Directory of Open Access Journals (Sweden)

    Einat eLevy-Gigi


    Full Text Available Studies on first responders who are repeatedly exposed to traumatic events report low levels of PTSD symptoms and diagnosis. However, neuroimaging and behavioral studies show that traumatic exposure is associated with brain and cognitive dysfunctions. Taking together it may suggest that traumatic exposure have a price, which is not sufficiently defined by the standard PTSD measures. In a recent study we revealed that similar to individuals with PTSD, non-PTSD highly exposed firefighters display a selective impairment in hippocampal related functions. In the current study we aimed to test whether different first responders display a similar impairment. We concentrated on unique populations of active duty firefighters and criminal scene-investigators (CSI police, who are frequently exposed to similar levels and types of traumatic events, and compared them to civilian matched-controls with no history of trauma-exposure. We used a hippocampal dependent cue-context reversal paradigm, which separately evaluates reversal of negative and positive outcomes of cue and context related information. We predicted and found that all participants were equally able to acquire and retain stimulus-outcome associations. However, there were significant differences in reversal learning between the groups. Performance among firefighters replicated our prior findings; they struggled to learn that a previously negative context is later associated with a positive outcome. CSI police on the other hand showed a selective impairment in reversing the outcome of a negative cue. Hence after learning that a specific cue is associated with a negative outcome, they could not learn that later it is associated with a positive outcome. Performance in both groups did not correlate with levels of PTSD, anxiety, depression or behavioral inhibition symptoms. The results provide further evidence of the hidden price of traumatic exposure, suggesting that this price may differ as a

  7. Heat transfer to finned tubes exposed to hot waste gas

    Energy Technology Data Exchange (ETDEWEB)

    Scholand, E.; Kremer, H.


    Transfer of heat by forced convection to finned tubes, particularly to those with an elliptical center pipe, is described. These pipes are used in gas-fired water heaters, boilers, and heat exchangers. Finned tubes in a test tunnel were exposed to a stream of waste gas from a gas/air mixture at different Reynolds numbers. Mathematical relationships showing the dependence of the Nusselt number on the Reynolds number and on the geometry of the tubes were derived. The single pipe showed a significant drop in the heat-transfer coefficient as the gap between fins became closer. The results of the measurement of heat transfer by forced convection to finned tubes were expressed in a standard form for all tubes. The same heat transfer law can be applied to electrically heated finned tubes exposed to a stream of cooling air.

  8. First responder tracking and visualization for command and control toolkit (United States)

    Woodley, Robert; Petrov, Plamen; Meisinger, Roger


    In order for First Responder Command and Control personnel to visualize incidents at urban building locations, DHS sponsored a small business research program to develop a tool to visualize 3D building interiors and movement of First Responders on site. 21st Century Systems, Inc. (21CSI), has developed a toolkit called Hierarchical Grid Referenced Normalized Display (HiGRND). HiGRND utilizes three components to provide a full spectrum of visualization tools to the First Responder. First, HiGRND visualizes the structure in 3D. Utilities in the 3D environment allow the user to switch between views (2D floor plans, 3D spatial, evacuation routes, etc.) and manually edit fast changing environments. HiGRND accepts CAD drawings and 3D digital objects and renders these in the 3D space. Second, HiGRND has a First Responder tracker that uses the transponder signals from First Responders to locate them in the virtual space. We use the movements of the First Responder to map the interior of structures. Finally, HiGRND can turn 2D blueprints into 3D objects. The 3D extruder extracts walls, symbols, and text from scanned blueprints to create the 3D mesh of the building. HiGRND increases the situational awareness of First Responders and allows them to make better, faster decisions in critical urban situations.

  9. Towards a respondent-preferred ki-anonymity model

    Institute of Scientific and Technical Information of China (English)

    Kok-Seng WONG; Myung Ho KIM


    Recently, privacy concerns about data collection have received an increasing amount of attention. In data collection process, a data collector (an agency) assumed that all respondents would be comfortable with submitting their data if the published data was anonymous. We believe that this assumption is not realistic because the increase in privacy concerns causes some re-spondents to refuse participation or to submit inaccurate data to such agencies. If respondents submit inaccurate data, then the usefulness of the results from analysis of the collected data cannot be guaranteed. Furthermore, we note that the level of anonymity (i.e., k-anonymity) guaranteed by an agency cannot be verified by respondents since they generally do not have access to all of the data that is released. Therefore, we introduce the notion of ki-anonymity, where ki is the level of anonymity preferred by each respondent i. Instead of placing full trust in an agency, our solution increases respondent confidence by allowing each to decide the preferred level of protection. As such, our protocol ensures that respondents achieve their preferred ki-anonymity during data collection and guarantees that the collected records are genuine and useful for data analysis.

  10. First responder and physician liability during an emergency. (United States)

    Eddy, Amanda


    First responders, especially emergency medical technicians and paramedics, along with physicians, will be expected to render care during a mass casualty event. It is highly likely that these medical first responders and physicians will be rendering care in suboptimal conditions due to the mass casualty event. Furthermore, these individuals are expected to shift their focus from individually based care to community- or population-based care when assisting disaster response. As a result, patients may feel they have not received adequate care and may seek to hold the medical first responder or physician liable, even if they did everything they could given the emergency circumstances. Therefore, it is important to protect medical first responders and physicians rendering care during a mass casualty event so that their efforts are not unnecessarily impeded by concerns about civil liability. In this article, the author looks at the standard of care for medical first responders and physicians and describes the current framework of laws limiting liability for these persons during an emergency. The author concludes that the standard of care and current laws fail to offer adequate liability protection for medical first responders and physicians, especially those in the private sector, and recommends that states adopt clear laws offering liability protection for all medical first responders and physicians who render assistance during a mass casualty event.

  11. Pregabalin and placebo responders show different effects on central pain processing in chronic pancreatitis patients

    Directory of Open Access Journals (Sweden)

    Bouwense SA


    Full Text Available Stefan AW Bouwense,1 Søren S Olesen,2 Asbjørn M Drewes,2 Harry van Goor,1 Oliver HG Wilder-Smith31Pain and Nociception Neuroscience Research Group, Department of Surgery, Radboud university medical center, Nijmegen, The Netherlands; 2Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; 3Pain and Nociception Neuroscience Research Group, Department of Anaesthesiology, Pain and Palliative Medicine, Radboud university medical center, Nijmegen, The NetherlandsBackground: Pain control in chronic pancreatitis is a major challenge; the mechanisms behind analgesic treatment are poorly understood. This study aims to investigate the differences in pain sensitivity and modulation in chronic pancreatitis patients, based on their clinical response (responders vs nonresponders to placebo or pregabalin treatment. Methods: This study was part of a randomized, double-blind, placebo-controlled trial evaluating the analgesic effects of pregabalin and placebo in chronic pancreatitis. Post hoc, patients were assigned to one of four groups, ie, responders and nonresponders to pregabalin (n=16; n=15 or placebo (n=12; n=17 treatment. Responders were defined as patients with >30% pain reduction after 3 weeks of treatment. We measured change in pain sensitivity before and after the treatment using electric pain detection thresholds (ePDT in dermatomes C5 (generalized effects and Ventral T10 (segmental effects. Descending endogenous pain modulation was quantified via conditioned pain modulation (CPM paradigm. Results: Sixty patients were analyzed in a per-protocol analysis. ePDT change in C5 was significant vs baseline and greater in pregabalin (1.3 mA vs placebo responders (−0.1 mA; P=0.015. This was not so for ePDT in Ventral T10. CPM increased more in pregabalin (9% vs placebo responders (−17%; P<0.001. CPM changed significantly vs baseline only for pregabalin responders (P=0.006. Conclusion: This hypothesis

  12. EXPOSE-R2, the 3rd successful EXPOSE mission – a mission and mission ground reference overview



    For nearly 2 years the 3rd ESA EXPOSE mission, the 2nd on the Russian Zvezda module of the ISS, exposed a variety of astrobiological samples to space and simulated Mars environmental conditions. Various chemical compounds and organisms like bacteria, archaea, fungi, plant seeds, lychens, mosses and animal eggs and larvae from the international experiments BIOMEX, BOSS, P.S.S. and the IBMP-experiment were exposed to space vacuums dryness, extraterrestrial short wavelength UV, radiation and tem...

  13. Assessment of Odor Annoying Impacts on Trade and Serving Centers Close to a Vegetable Oil Manufacturing Plant

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Monazzam


    Full Text Available The environmental odor pollution emitted from different sources has undesirable impacts on communities' health and welfare in a way that caused increasing public worry and complains around the world.Pars Vegetable Oil Processing Plant (PVOPP is located near populated residential areas in Tehran; hence, many people are exposed to the plant process annoying odor daily. In order to assess the odor annoying impacts on its nearby business centers a social survey has been applied.In the field area 200 questionnaires were intended to be filled out but 180 of them have been completed by the respondents (90%. Almost 98% of the respondents have perceived the odor from the outdoor source in their working places which is known as the industry by 78% of them. Among the respondents 42% of them have defined the odor as intolerable.Considering that industry has been recognized as the most important external parameter which affect the quality of working environments, the impact of this industrial unit on decreasing the quality level of working conditions is more obvious. The duration of presence in the working place and record of service are related to disorders in working activity and emotion and thus confirm the odor pollution impacts on the employees' efficiency.

  14. Responder Technology Alert Monthly (Oct-Nov 2014)

    Energy Technology Data Exchange (ETDEWEB)

    Upton, Jaki F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stein, Steven L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)


    As part of technology foraging for the Responder Technology Alliance, established by the Department of Homeland Science and Technologies First Responders Group, this report summarizes technologies that are relevant in the area of “wearables,” with the potential for use by first responders. The content was collected over the previous month(s) and reproduced from a general Internet search using the term wearables. Additional information is available at the websites provided. This report is not meant to be an exhaustive list nor an endorsement of any technology described herein. Rather, it is meant to provide useful information about current developments in the areas wearable technology.

  15. Effect of Light/Dark Cycle on Wheel Running and Responding Reinforced by the Opportunity to Run Depends on Postsession Feeding Time (United States)

    Belke, T. W.; Mondona, A. R.; Conrad, K. M.; Poirier, K. F.; Pickering, K. L.


    Do rats run and respond at a higher rate to run during the dark phase when they are typically more active? To answer this question, Long Evans rats were exposed to a response-initiated variable interval 30-s schedule of wheel-running reinforcement during light and dark cycles. Wheel-running and local lever-pressing rates increased modestly during…

  16. Co-responding Police-Mental Health Programs: A Review. (United States)

    Shapiro, G K; Cusi, A; Kirst, M; O'Campo, P; Nakhost, A; Stergiopoulos, V


    Co-responding police-mental health programs are increasingly used to respond to 'Emotionally Disturbed Persons' in the community; however, there is limited understanding of program effectiveness and the mechanisms that promote program success. The academic and gray literature on co-responding police-mental health programs was reviewed. This review synthesized evidence of outcomes along seven dimensions, and the available evidence was further reviewed to identify potential mechanisms of program success. Co-responding police-mental health programs were found to have strong linkages with community services and reduce pressure on the justice system, but there is limited evidence on other impacts. The relevance of these findings for practitioners and the major challenges of this program model are discussed, and future research directions are identified.

  17. Emergency First Responders' Experience with Colorimetric Detection Methods

    Energy Technology Data Exchange (ETDEWEB)

    Sandra L. Fox; Keith A. Daum; Carla J. Miller; Marnie M. Cortez


    Nationwide, first responders from state and federal support teams respond to hazardous materials incidents, industrial chemical spills, and potential weapons of mass destruction (WMD) attacks. Although first responders have sophisticated chemical, biological, radiological, and explosive detectors available for assessment of the incident scene, simple colorimetric detectors have a role in response actions. The large number of colorimetric chemical detection methods available on the market can make the selection of the proper methods difficult. Although each detector has unique aspects to provide qualitative or quantitative data about the unknown chemicals present, not all detectors provide consistent, accurate, and reliable results. Included here, in a consumer-report-style format, we provide “boots on the ground” information directly from first responders about how well colorimetric chemical detection methods meet their needs in the field and how they procure these methods.

  18. What Is That Lapping the Miles?: Responding to Reader Response. (United States)

    Seib, Kenneth


    Responds to an article in an earlier issue of this journal about using reading response in a college literature classroom. Argues that the use of reader-response theory with two-year college students requires some caution. (SR)

  19. Cocaine and automaintained responding in pigeons: rate-reducing effects and tolerance thereto with different durations of food delivery. (United States)

    Durgin, Amy; Porter, Lindsay K; Bradley, Kelly P; Laraway, Sean; Poling, Alan


    Pigeons were exposed to an automaintenance procedure in which 6-s key illuminations in one color (red or white) were immediately followed by 3-s food deliveries and key illuminations in the other color were followed by 9-s food deliveries. Both conditions engendered consistent responding. With both durations of food delivery, acute and chronic cocaine administrations (1.0-17.8 mg/kg) produced dose-dependent decreases in mean percent trials (key illuminations) with a response and mean total response per session. Tolerance developed to the disruptive effects of cocaine on both response measures. Food duration did not significantly affect either response measure or significantly interact with cocaine dose or drug regimen. The orderliness of the present findings, like those of a related study examining whether probability of food delivery modulated the effects of cocaine on automaintained responding [Porritt, M., Arnold, M., Poling, A., Cocaine and automaintained responding in pigeons: rate-reducing effects and tolerance thereto with different CS-US pairing probabilities. Pharmacol Biochem Behav 2007; 87:405-411.], suggests that the automaintenance procedure is a useful assay for examining tolerance to drug effects on classically-conditioned responding. Unlike the results of that study, however, the present findings are inconsistent with a behavioral momentum analysis of drug effects on such responding.

  20. Functional Properties of Tooth Pulp Neurons Responding to Thermal Stimulation


    Ahn, D.K.; Doutova, E.A.; McNaughton, K.; Light, A.R.; Närhi, M.; Maixner, W.


    The response properties of tooth pulp neurons that respond to noxious thermal stimulation of the dental pulp have been not well-studied. The present study was designed to characterize the response properties of tooth pulp neurons to noxious thermal stimulation of the dental pulp. Experiments were conducted on 25 male ferrets, and heat stimulation was applied by a computer-controlled thermode. Only 15% of tooth pulp neurons (n = 39) responded to noxious thermal stimulation of the teeth. Tooth ...

  1. Preliminary indications of blood lead concentrations, among occupationally exposed and non exposed Palestinians

    Directory of Open Access Journals (Sweden)

    Mutaz A. Al-Qutob


    Full Text Available Despite the lower rate of exposure to leaded compounds in the past ten years, due to reducedlead petrol concentrations in the ambient air and improvement in environmental control measures, leadpoisoning is still an occupational and environmental disease of great concern in public health. Thepresence of other sources of lead exposure after the ban of leaded gasoline could be a risk factor forelevated blood lead concentrations. In this study blood lead levels (BLL were screened in bothoccupationally and non-occupationally exposed groups in the Palestinian Territories by inductive coupledplasma-mass spectrometry (Agilent 7500 ICP-MS. The non-occupationally exposed groups included 18normal healthy smoker males, 18 non smoker males, and 18 females. Occupationally exposed groupsinclude 25 workers in the assaying and refining of gold and 19 workers in auto-repair garages. Data wasanalyzed using the statistical computer package (SPSS. Mean blood lead levels of all groups were belowthe action level according to Centers for Disease Control (CDC and Occupational Safety and HealthAdministration (OSHA (<10 μg/dL. No statistical significant differences were found between workersgroup and control groups. In the control group, a paired t-test showed a statistically significant difference(p<0.05 between the female group and smoker male group. There was no correlation with age for allgroups except the female group and auto-repair workers which showed significant correlation (p<0.05with both age and years of work. This could be contributed to differences in genetic make-up, chemicalexposure history and age related decreased function of the detoxification processes. Since mean BLL(3.66 μg/dL of the control group was comparable to economically advantaged countries like USA (1.6μg/dL and those with low mean of (1.96 μg/dL like Jordan, lead is not considered a majorenvironmental pollutant in Palestine and the screening is recommended only at the workers in

  2. Patient-centered Communication survey of nursing homes and rehabilitation centers. (United States)

    Skinder-Meredith, Amy; Bye, Lynn; Bulthuis, Kari; Schueller, Angie


    A surge of research has recently been published on the importance ofpatient-centered communication (P-CC). However, patients with communication disorders are rarely considered in these discussions. Health care workers in long-term care facilities (L-TCFs) and rehabilitation centers were surveyed in order to: (1) assess the level of P-CC used with people with communication disorders versus those without communication disorders; (2) identify the tools and strategies currently used by health care providers in long-term care facilities and rehabilitation centers to enhance P-CC with people with communication disorders; (3) assess the perceived level of efectiveness of these tools and strategies; and (4) identify the tools desired by health care providers in these settings. The results regarding P-CC levels were fairly consistent across settings. Health care providers reported that they achieve slightly higher P-CC with patients without communication disorders than with those with communication disorders. Respondents in both settings used similar tools and strategies, but the reported level of effectiveness varied greatly between the two settings, with rehabilitation centers indicating better success than L-TCFs. Interestingly, rehabilitation center respondents were more interested in obtaining additional tools than were L-TCF respondents, but the types of tools desired were similar.

  3. Transplant Center Search Form (United States)

    ... Share Your Story Give Us Feedback - A + A Transplant Center Search Form Welcome to the Blood & Marrow ... transplant centers for patients with a particular disease. Transplant Center login Username: * Password: * Request new password Join ...

  4. Children's cancer centers (United States)

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... Treating childhood cancer is not the same as treating adult cancer. The cancers are different. So are the treatments and the ...

  5. Transplant organizational structures: viewpoints from established centers. (United States)

    Abouljoud, M; Klintmalm, G; Whitehouse, S


    This personal viewpoint report summarizes the responses of a survey targeting established transplant programs with a structured framework, such as center, institute, or department, and stability of leadership to assure valuable experiential observations. The 18-item survey was sent to 20 US institutions that met inclusion criteria. The response rate was 100%. Seventeen institutions had a distinct transplant governance structure. A majority of respondents perceived that their type of transplant structure was associated with enhanced recognition within their institution (85%), improved regulatory compliance (85%), transplant volume growth (75%), improved quality outcomes (75%) and increased funding for transplant-related research (75%). The prevailing themes in respondents' remarks were the perceived need for autonomy of the transplant entity, alignment among services and finances and alignment of authority with responsibility. Many respondents suggested that a dialogue be opened about effective transplant infrastructure that overcomes the boundaries of traditional academic department silos.

  6. Investigating Empathy-Like Responding to Conspecifics' Distress in Pet Dogs.

    Directory of Open Access Journals (Sweden)

    Mylene Quervel-Chaumette

    Full Text Available Empathy covers a wide range of phenomena varying according to the degree of cognitive complexity involved; ranging from emotional contagion, defined as the sharing of others' emotional states, to sympathetic concern requiring animals to have an appraisal of the others' situation and showing concern-like behaviors. While most studies have investigated how animals reacted in response to conspecifics' distress, dogs so far have mainly been targeted to examine cross-species empathic responses. To investigate whether dogs would respond with empathy-like behavior also to conspecifics, we adopted a playback method using conspecifics' vocalizations (whines recorded during a distressful event as well as control sounds. Our subjects were first exposed to a playback phase where they were subjected either to a control sound, a familiar whine (from their familiar partner or a stranger whine stimulus (from a stranger dog, and then a reunion phase where the familiar partner entered the room. When exposed to whines, dogs showed a higher behavioral alertness and exhibited more stress-related behaviors compared to when exposed to acoustically similar control sounds. Moreover, they demonstrated more comfort-offering behaviors toward their familiar partners following whine playbacks than after control stimuli. Furthermore, when looking at the first session, this comfort offering was biased towards the familiar partner when subjects were previously exposed to the familiar compared to the stranger whines. Finally, familiar whine stimuli tended to maintain higher cortisol levels while stranger whines did not. To our knowledge, these results are the first to suggest that dogs can experience and demonstrate "empathic-like" responses to conspecifics' distress-calls.

  7. Comparison of the Effects of Exposure to Different Particles or Energies on Behavioral Responding in Rats (United States)

    Rabin, B. M.; Shukitt-Hale, B.; Joseph, J. A.; Carey, A.

    On exploratory class missions, astronauts will be exposed to a variety of heavy particles which differ in terms of quality and energy. Previous research has shown that exposure to 56Fe particles (1 GeV/n) can disrupt performance on taste aversion (CTA) learning and on operant responding using an ascending fixed-ratio schedule of reinforcement. How exposure to different types of particles and different energies will affect performance remains to be established. Rats were exposed to 56Fe (1 GeV/n, 5 GeV/n), 48Ti (1.2 GeV/n)) or 28Si (600 MeV/n) using the AGS or NSRL at Brookhaven National Laboratory. Three days following exposure, the rats were tested for the acquisition of an amphetamine-induced CTA. Compared to 1 GeV/n 56Fe, exposure to 5 GeV/n 56Fe particles required higher doses to disrupt the acquisition of an amphetamine-induced CTA. The dose-response curve for a 48Ti-induced disruption of CTA learning was similar to that produced by exposure to 1 GeV/n 56Fe particles, despite the difference in the LET of the two types of particles. In contrast the rats exposed to 28Si failed to show disruption of amphetamine-induced CTA learning, following exposure to 2.0-4.0 Gy. When tested on a ascending fixed-ratio operant task, the rats exposed to 5 GeV/n 56Fe, in contrast to the rats irradiated with 1 GeV/n 56Fe, did not show poorer performance than the non irradiated controls. These results show that the effects of exposure to heavy particles depend upon the specific particle, its energy, and the endpoint being tested. Supported by NASA Grants NAG9-1190 and NAG9-1529

  8. Women's health centers and specialized services. (United States)

    LaFleur, E K; Taylor, S L


    More than 75% of the female respondents in this study would choose a women's health center (WHC) over a standard health facility. Women who worked outside the home perceived a greater WHC need. And almost all respondents were interested in communications from the center via a quarterly newsletter. Significant test results related to age, income, education, and work status as segmentation variables, offering WHC's an opportunity to target their patients with specialized services such as cosmetic surgery, infertility treatment, breast imaging, etc. If enough resources are allocated, a WHC can design itself to attract highly lucrative patients. Little difference was found in the opinions of women regarding the need for a WHC or the core services desired, but the specific service mix decision must be carefully considered when designing a WHC.

  9. Southern California Particle Center (United States)

    Federal Laboratory Consortium — At the Southern California Particle Center, center researchers will investigate the underlying mechanisms that produce the health effects associated with exposure to...

  10. Womens Business Center (United States)

    Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

  11. A Comparison of Gene Expression Profiles between Glucocorticoid Responder and Non-Responder Bovine Trabecular Meshwork Cells Using RNA Sequencing (United States)

    Bermudez, Jaclyn Y.; Webber, Hannah C.; Brown, Bartley; Braun, Terry A.; Clark, Abbot F.; Mao, Weiming


    The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT occurs in about 40% of the general population, while the other 60% are resistant. This study aims to determine the genes and pathways involved in differential GC responsiveness in the trabecular meshwork (TM). Using paired bovine eyes, one eye was perfusion-cultured with 100nM dexamethasone (DEX), while the fellow eye was used to establish a bovine TM (BTM) cell strain. Based on maximum IOP change in the perfused eye, the BTM cell strain was identified as a DEX-responder or non-responder strain. Three responder and three non-responder BTM cell strains were cultured, treated with 0.1% ethanol or 100nM DEX for 7 days. RNA and proteins were extracted for RNA sequencing (RNAseq), qPCR, and Western immunoblotting (WB), respectively. Data were analyzed using the human and bovine genome databases as well as Tophat2 software. Genes were grouped and compared using Student’s t-test. We found that DEX induced fibronectin expression in responder BTM cells but not in non-responder cells using WB. RNAseq showed between 93 and 606 differentially expressed genes in different expression groups between responder and non-responder BTM cells. The data generated by RNAseq were validated using qPCR. Pathway analyses showed 35 pathways associated with differentially expressed genes. These genes and pathways may play important roles in GC-induced OHT and will help us to better understand differential ocular responsiveness to GCs. PMID:28068412

  12. National Infrastructure Simulation and Analysis Center Overview

    Energy Technology Data Exchange (ETDEWEB)

    Berscheid, Alan P. [Los Alamos National Laboratory


    National Infrastructure Simulation and Analysis Center (NISAC) mission is to: (1) Improve the understanding, preparation, and mitigation of the consequences of infrastructure disruption; (2) Provide a common, comprehensive view of U.S. infrastructure and its response to disruptions - Scale & resolution appropriate to the issues and All threats; and (3) Built an operations-tested DHS capability to respond quickly to urgent infrastructure protection issues.

  13. Learning environment simulator: a tool for local decision makers and first responders

    Energy Technology Data Exchange (ETDEWEB)

    Leclaire, Rene J [Los Alamos National Laboratory; Hirsch, Gary B [CLE, INCORPORATED


    The National Infrastructure Simulation and Analysis Center (NISAC) has developed a prototype learning environment simulator (LES) based on the Critical Infrastructure Protection Decision Support System (CIPDSS) infrastructure and scenario models. The LES is designed to engage decision makers at the grass-roots level (local/city/state) to deepen their understanding of an evolving crisis, enhance their intuition and allow them to test their own strategies for events before they occur. An initial version is being developed, centered on a pandemic influenza outbreak and has been successfully tested with a group of hospital administrators and first responders. LES is not a predictive tool but rather a simulated environment allowing the user to experience the complexities of a crisis before it happens. Users can contrast various approaches to the crisis, competing with alternative strategies of their own or other participants. LES is designed to assist decision makers in making informed choices by functionally representing relevant scenarios before they occur, including impacts to critical infrastructures with their interdependencies, and estimating human health & safety and economic impacts. In this paper a brief overview of the underlying models are given followed by a description of the LES, its interface and usage and an overview of the experience testing LES with a group of hospital administrators and first responders. The paper concludes with a brief discussion of the work remaining to make LES operational.

  14. Daily hassles, their antecedents and outcomes among professional first responders: A systematic literature review. (United States)

    Larsson, Gerry; Berglund, Anna Karin; Ohlsson, Alicia


    Occupational groups such as firefighters, military officers, paramedics and police officers are exposed to a combination of acute, severe and accumulated everyday stress. Drawing on the daily hassles perspective on stress, the aim was to synthesize existing research on daily hassles in professional first responder settings into a theoretical model. A systematic mixed studies review with an integrated design was undertaken. The selection process resulted in 40 articles meeting the inclusion criteria. The selected papers represented two literature reviews, one qualitative study, eight longitudinal studies and 29 cross-sectional studies. Five superior categories emerged in the analysis: Individual antecedent and continuously framing factors, Environmental antecedent and continuously framing factors, Appraisal and coping processes, Daily hassles and Outcome. Suggestions for future research are presented.

  15. Altered immunological reactivity in HIV-1-exposed uninfected neonates. (United States)

    Hygino, Joana; Lima, Patrícia G; Filho, Renato G S; Silva, Agostinho A L; Saramago, Carmen S M; Andrade, Regis M; Andrade, Daniel M; Andrade, Arnaldo F B; Brindeiro, Rodrigo; Tanuri, Amilcar; Bento, Cleonice A M


    This work aimed to evaluate immune events in HIV-1-exposed uninfected neonates born from mothers who control (G1) or not (G2) the plasma viral load, using unexposed neonates as controls. Cord blood from each neonate was collected, plasma and mononuclear cells were separated and the lymphoproliferation and cytokine pattern were evaluated. The results demonstrated that the in vitro lymphoproliferation induced by polyclonal activators was higher in the G2 neonates. Nevertheless, no cell culture responded to poll synthetic HIV-1 envelope peptides. The cytokine dosage in the plasma and supernatants of polyclonally-activated cultures demonstrated that, while IL-4 and IL-10 were the dominant cytokines produced in G1 and control groups, IFN-gamma and TNF-alpha were significantly higher in G2 neonates. Systemic levels of IL-10 observed among the G1 neonates were higher in those born from anti-retroviral treated mothers. In summary, our results indicate an altered immune responsiveness in neonates exposed in utero to HIV and support the role of maternal anti-retroviral treatment to attenuate it.

  16. Student Success Center Toolkit (United States)

    Jobs For the Future, 2014


    "Student Success Center Toolkit" is a compilation of materials organized to assist Student Success Center directors as they staff, launch, operate, and sustain Centers. The toolkit features materials created and used by existing Centers, such as staffing and budgeting templates, launch materials, sample meeting agendas, and fundraising…

  17. Taiyuan Satellite Launch Center

    Institute of Scientific and Technical Information of China (English)



    There are three major space launch bases in China, the Jiuquan Satellite Launch Center,the Taiyuan Satellite Launch Center and the Xichang Satellite Launch Center. All the three launch centers are located in sparsely populated areas where the terrain is even and the field of vision is broad. Security, transport conditions and the influence of the axial rotation

  18. Eryptosis in lead-exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Dorado, Itzel-Citlalli [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Hernández, Gerardo [Section of Methodology of Science, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Quintanar-Escorza, Martha-Angelica [Faculty of Medicine, UJED, Durango, DGO (Mexico); Maldonado-Vega, María [CIATEC, León, GTO (Mexico); Rosas-Flores, Margarita [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico); Calderón-Salinas, José-Víctor, E-mail: [Biochemistry Department, Centro de Investigación y Estudios Avanzados IPN, México, DF (Mexico)


    Eryptosis is a physiological phenomenon in which old and damaged erythrocytes are removed from circulation. Erythrocytes incubated with lead have exhibited major eryptosis. In the present work we found evidence of high levels of eryptosis in lead exposed workers possibly via oxidation. Blood samples were taken from 40 male workers exposed to lead (mean blood lead concentration 64.8 μg/dl) and non-exposed workers (4.2 μg/dl). The exposure to lead produced an intoxication characterized by 88.3% less δ-aminolevulinic acid dehydratase (δALAD) activity in lead exposed workers with respect to non-lead exposed workers. An increment of oxidation in lead exposed workers was characterized by 2.4 times higher thiobarbituric acid-reactive substance (TBARS) concentration and 32.8% lower reduced/oxidized glutathione (GSH/GSSG) ratio. Oxidative stress in erythrocytes of lead exposed workers is expressed in 192% higher free calcium concentration [Ca{sup 2+}]{sub i} and 1.6 times higher μ-calpain activity with respect to non-lead exposed workers. The adenosine triphosphate (ATP) concentration was not significantly different between the two worker groups. No externalization of phosphatidylserine (PS) was found in non-lead exposed workers (< 0.1%), but lead exposed workers showed 2.82% externalization. Lead intoxication induces eryptosis possibly through a molecular pathway that includes oxidation, depletion of reduced glutathione (GSH), increment of [Ca{sup 2+}], μ-calpain activation and externalization of PS in erythrocytes. Identifying molecular signals that induce eryptosis in lead intoxication is necessary to understand its physiopathology and chronic complications. - Graphical abstract: Fig. 1. (A) Blood lead concentration (PbB) and (B) phosphatidylserine externalization on erythrocyte membranes of non-lead exposed (□) and lead exposed workers (■). Values are mean ± SD. *Significantly different (P < 0.001). - Highlights: • Erythrocytes of lead exposed workers

  19. Musical hallucinations responding to a further increase of carbamazepine. (United States)

    Aizawa, Saeko; Terao, Takeshi; Hatano, Koji; Ishii, Nobuyoshi


    A 73-year-old woman outpatient with mild cognitive impairment, parasomnia and depressive state with musical hallucinations failed to respond to 400 mg/day of valproate. Once she was admitted to a university hospital, her musical hallucinations partially responded to 1 mg/day of clonazepam and sufficiently improved on 100 mg/day of carbamazepine. Two months after discharge, however, her musical hallucinations recurred probably as a consequence of psychological stress. The increase of carbamazepine from 100 to 200 mg/day completely remitted her musical hallucinations. This case suggests that musical hallucinations respond in a dose-dependent manner to increasing carbamazepine, and that gradual titration from small doses of carbamazepine is required because optimal doses appear to be smaller than those required for epilepsy and bipolar disorder. Further studies are warranted to determine the therapeutic levels of carbamazepine for musical hallucinations.

  20. The Balanced Inventory of Desirable Responding Short Form (BIDR-16

    Directory of Open Access Journals (Sweden)

    Claire M. Hart


    Full Text Available Self-report studies often call for assessment of socially desirable responding. Many researchers use the Marlowe–Crowne Scale for its brief versions; however, this scale is outdated, and contemporary models of social desirability emphasize its multi-dimensional nature. The 40-item Balanced Inventory of Desirable Responding (BIDR incorporates Self-Deceptive Enhancement (honest but overly positive responding and Impression Management (bias toward pleasing others. However, its length limits its practicality. This article introduces the BIDR-16. In four studies, we shorten the BIDR from 40 items to 16 items, while retaining its two-factor structure, reliability, and validity. This short form will be invaluable to researchers wanting to assess social desirability when time is limited.

  1. Internal and external motivation to respond without sexism. (United States)

    Klonis, Suzanne C; Plant, E Ashby; Devine, Patricia G


    Based on Plant and Devine's (1998) measures of Internal and External Motivation to Respond Without Prejudice toward Blacks, new scales were developed to assess Internal and External Motivation to Respond Without Sexism (IMS-S and EMS-S, respectively). The scales possess good psychometric properties. Providing evidence of convergent and discriminant validity, the IMS-S was strongly related to measures of sexism yet unrelated to measures of social evaluation. The EMS-S was modestly related to both sexism and social evaluative concerns. Providing evidence of predictive validity, participants who were either internally or externally motivated to respond without sexism rated sexist jokes more negatively in a situation discouraging sexism compared to participants low in both sources of motivation. However, only high IMS-S participants rated the jokes negatively whether the situation encouraged or discouraged sexism and whether their response was public or private. Implications for understanding the similarities and differences between sexism and racism are discussed.

  2. How to respond to referee comments for scientific articles? (United States)

    Kalemci, Mustafa Serdar; Turna, Burak


    Currently, the increasing number of article submissions to scientific journals forces editors to be more selective in their acceptance of papers. Consequently, editors have increased the frequency of their use of scientific referee mechanisms. For many researchers, the publication of a scientific article in a high impact factor journal is a gradual and difficult process. After preparation and submission of a manuscript, one of the most important issue is responding to the comments of referees. However, there is a paucity of published reports in the literature describing how to respond to these comments. The aim of this review is to assist researchers/authors in responding to referee comments as part of the publication process for scientific articles.


    Directory of Open Access Journals (Sweden)

    Sukarno Sukarno


    Full Text Available Abstract:  Javanese has been studied from many different perspectives. However, no one discusses how Javanese respond to compliments politely. The aim of this study is to investigate the politeness strategies as applied to respond to compliments by the Javanese people in Jember, East Java. The notion of politeness plays crucial role in the realization of speech acts (utterances and verbal communication in Javanese, such as responding to compliements. As utterances and verbal communications should be interpreted based on the sosio-cultural background, the politeness strategies in responding to compliments in Javanese cannot be separated from the concepts of the Javanese culture, such as: andhap-asor (lowering oneself, while exalting the others and tanggap ing sasmita (understanding the hidden meaning. First, as a Javanese, one must be able to apply the concept of andhap-asor in responding to compliments by denigrating himself. Second, a good Javanese should also have a sense of tanggap ing sasmita while responding to compliments. Consequently, failure to apply one of the cultural factors can be detrimental to the speaker, reducing the harmony of the conversation. This paper examines how politeness is manifested and conveyed within the major framework of the Javanese culture. This study is about socio-cultural pragmatics in which utterances are discussed in relation to their situations, and the cultural background which support them. The data are in the form of dialogues among students-teachers, and students-students which show the different social status among the interlocutors. The data of this research were collected by recording, and by note taking (for the parts in which recording is not possible. The data are aimed to generate the strategies used by the Javanese (in Jember, Indonesia to build politeness strategies in responding to compliments. Finally, the data of this research are examined both from the general theory of politeness, and

  4. Some effects of punishment shock intensity upon discriminative responding. (United States)

    Powell, R W


    Three pigeons received visual discrimination training under both multiple variable-ratio extinction and variable-interval extinction schedules. All birds developed nearly perfect discrimination. When punishment for every tenth response during food reinforcement was presented, responding decreased as shock intensity increased. At the same time, responding during extinction, which was not punished, increased at intermediate punishment intensities, but returned to low levels under severe punishment. A second procedure, in which punishment and no-punishment sessions alternated unsystematically, was employed with two of the birds. The results under this procedure essentially replicated the data obtained as punishment shock intensity increased gradually.

  5. A phenomenological model for the dynamics of cell cycle in responding to X-rays

    Institute of Scientific and Technical Information of China (English)

    Zhang Sheng; Ao Bin; Ye Caiyong; Yang Lei; Zhou Guangming


    Objective To establish a model to predict the cell-cycle process in response to ionizing radiation.Methods Human choroidal malignant melanoma 92-1 cells were used and the cell cycle distribution of cells was analyzed in 0-96 h after exposure to X-rays.A phenomenological model was constructed based on biological knowledge to describe the cell cycle dynamics in experiments.Results In the present study,a phenomenological model was constructed to describe the cellcycle dynamics of synchronized 92-1 cells in responding to various doses of ionizing radiation.The simulation results obtained with the model were consistent with the experimental data,demonstrating that the model had a good expansibility and could be used to predict the dynamics of cell cycle in responding to ionizing radiation.Further theoretical modeling of the cellcycle dynamics was made and the results were consistent with the simulation.Conclusions A phenomenological model was constructed which could be used to describe the dynamics of cell cycle of cells exposed to ionizing radiation and was supported by the experimental data.Because this model is easy to run by the written code,it has a good expansibility for studying the behaviors of cell populations under various conditions.

  6. Hazardous Materials Management and Emergency Response training Center needs assessment

    Energy Technology Data Exchange (ETDEWEB)

    McGinnis, K.A. [Westinghouse Hanford Co., Richland, WA (United States); Bolton, P.A. [Pacific Northwest Lab., Richland, WA (United States); Robinson, R.K. [RKR, Inc. (United States)


    For the Hanford Site to provide high-quality training using simulated job-site situations to prepare the 4,000 Site workers and 500 emergency responders for known and unknown hazards a Hazardous Materials Management and Emergency Response Training Center is needed. The center will focus on providing classroom lecture as well as hands-on, realistic training. The establishment of the center will create a partnership among the US Department of Energy; its contractors; labor; local, state, and tribal governments; and Xavier and Tulane Universities of Louisiana. This report presents the background, history, need, benefits, and associated costs of the proposed center.

  7. Center for the Study of Traumatic Stress (United States)


    problems of those exposed to war, disaster and other traumatic events. Third, we are dedicated to research in translational studies, neuro- science ...and high- ly-productive team functions in a well-coordinated manner and in a unified direction . That combined effort and synergy results in the rapid...Center continued its clinical work in neuro- science and neurobiology by conducting clinical trials to improve the treatment of stress, PTSD and TBI

  8. 77 FR 56622 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting...: Notice of Open Public Meeting. SUMMARY: This notice announces an open public meeting of the Board of the..., from 9 a.m. to 12:30 p.m. Eastern Time. ADDRESSES: Board members will meet in the...

  9. 78 FR 2660 - First Responder Network Authority Board Meeting (United States)


    ... National Telecommunications and Information Administration First Responder Network Authority Board Meeting...: Notice of open public meeting. SUMMARY: This notice announces an open public meeting of the Board of the... 9 a.m. to 12:30 p.m. Mountain Standard Time. ADDRESSES: Board members will meet at the...

  10. Context modulates effects of nicotine abstinence on human cooperative responding. (United States)

    Spiga, R; Day, J D; Schmitz, J M; Broitman, M; Elk, R; Caperton-Brown, H


    The effects of ad libitum smoking, abstinence, and 0-, 2-, and 4-mg nicotine gum on human cooperative responding were examined. Participants were provided the opportunity to respond cooperatively or independently to episodes initiated by a computer-simulated other person. Participants could also initiate episodes that ostensibly provided the other person the opportunity to respond cooperatively or independently of the participant. Working cooperatively added points to both the participant's and other person's counters. Working independently added points only to the participant's counter. Results demonstrated that abstinence decreased cooperative responses during episodes initiated by the computer-stimulated other person. Relative to abstinence and placebo gum conditions, ad libitum smoking and administration of 2- and 4-mg nicotine gum increased these cooperative responses. No gender differences were observed. The number of cooperative episodes initiated by the participants was not affected significantly by the smoking or gum conditions. Nicotine increased reports of vigor and decreased abstinence-engendered reports of depression, anger, confusion, and tension. The difference in the effects of nicotine abstinence on the 2 classes of cooperative responding demonstrates that the social contingency mediates the behavioral effects of abstinence.

  11. Training Emergency Responders: Sudden Infant Death Syndrome. An Instructor's Manual. (United States)

    Applied Science Associates, Inc., Reston, VA.

    This manual was developed to help instructors train police and emergency medical technicians, who often are the first persons to arrive at the scene of a death (first responders), to serve families who lose a child to Sudden Infant Death Syndrome (SIDS). The manual begins with an introduction that discusses the purpose of the training and…

  12. Do Sighted People Respond to Different Levels of Visual Loss? (United States)

    Feinman, Saul


    In the study, eight random samples of respondents (236 adult Ss) from a small Western city were presented with questionnaires which requested that they evaluate the characteristics of a stimulus person who varied by sightedness (blind, totally sightless, partially sighted, sighted), and age (35 or 65 years). (Author/SBH)

  13. Assessment of Respondent Acceptability for Preference Measures in Stuttering (United States)

    Franic, Duska M.; Bothe, Anne K.; Bramlett, Robin E.


    Purpose: To assess the feasibility of using one or more of four standard economic preference measures to assess health-related quality of life in stuttering, by assessing respondents' views of the acceptability of those measures. Method and results: A graphic positioning scale approach was used with 80 adults to assess four variables previously…

  14. Responding to LGBT forced migration in East Africa

    Directory of Open Access Journals (Sweden)

    Gitta Zomorodi


    Full Text Available Following the passage of Uganda’s Anti-Homosexuality Act in December 2013, hundreds of LGBT individuals fled to Kenya seeking safety. A variety of interventions is needed in both Uganda and Kenya to respond effectively.

  15. Authors' Rejoinder to Respondents (Shulman, Steinberg, & Piquero, 2013) (United States)

    Males, Mike A.; Brown, Elizabeth A.


    Respondents, in "A Mistaken Account of the Age-Crime Curve: Response to Males and Brown," dispute our finding that virtually all of the discrepancy in violent crime rates between adolescents/emerging adults versus older adults is explained not by young age per se but by higher poverty levels among the young. Our rejoinder argues that…

  16. Dissociating indifferent, directional, and extreme responding in personality data

    DEFF Research Database (Denmark)

    Zettler, Ingo; Lang, Jonas W B; Hülsheger, Ute R


    OBJECTIVE: Research suggests that respondents vary in their tendency to use the response scale of typical (Likert-style) questionnaires. We study the nature of the response process by applying a recently introduced item response theory modeling procedure, the three-process model, to data of self-...

  17. The University College: Responding to the Needs of Adult Learners (United States)

    Lewis, Jerry J.


    Colleges and universities are being challenged to meet the diverse needs of the increasing numbers of adult learners enrolling in developmental education courses. Some administrators have responded to this challenge with administrative units called University Colleges. These units are infrequently discussed in the literature. This article briefly…

  18. Increasing Students' Opportunities to Respond: A Strategy for Supporting Engagement (United States)

    Menzies, Holly M.; Lane, Kathleen Lynne; Oakes, Wendy Peia; Ennis, Robin Parks


    This article offers a rationale for using a low-intensity support, increasing opportunities to respond, to promote students' academic engagement and decrease disruptive behaviors. A step-by-step guide to implementing this strategy in the classroom setting is presented.

  19. 45 CFR 5.24 - Responding to your request. (United States)


    ... will retrieve and review them for possible disclosure. However, the Federal Government destroys many.... We are not compelled to create new records. For example, we are not required to write a new program... information on paper, we will do this if it is the only way to respond to a request. Nor are we required...

  20. 20 CFR 402.145 - Responding to your request. (United States)


    ... THE PUBLIC § 402.145 Responding to your request. (a) Retrieving records. We are required to furnish... perform research for you. We may decide to conserve Government resources and at the same time supply the... that is exempt from disclosure. For example, in an opinion or order, statement of policy, or...

  1. The recurrence of negatively reinforced responding of humans. (United States)

    Alessandri, Jérôme; Lattal, Kennon A; Cançado, Carlos R X


    The recurrence of negatively reinforced responding of humans was studied in three experiments. In each experiment during Baseline, key-pressing produced 3-s timeouts from a requirement to exert finger pressure on a force cell according to variable- or fixed-ratio schedules of reinforcement. In Experiment 1, resurgence was studied by arranging a differential-reinforcement-of-other-behavior schedule in the second phase, and extinction in the Test phase. In Experiment 2, ABA renewal was studied by extinguishing responding in the second phase in a different context and, in the Test phase, by presenting the Baseline-phase context when extinction still was in effect. In Experiment 3, reinstatement was studied by arranging extinction in the second phase, followed by the delivery of response-independent timeouts in the Test phase. Resurgence and renewal occurred consistently for each participant in Experiments 1 and 2, respectively. In Experiment 3, reinstatement was observed less consistently in four participants. The results of these experiments replicate and extend to negatively reinforced responding previous findings of the resurgence and renewal of positively reinforced responding obtained mainly with nonhuman animals.

  2. Critical velocity and dynamic respondency of pipe conveying fluid

    Institute of Scientific and Technical Information of China (English)


    Presents the calculation of critical velocity, natural frequencyand dynamic respondency of fluid-conveying pipe are calculated under different boundary conditions using finite element method, and the use of calculation results to design and research rocket pipes feeding fuel and watery turbine pipes conveying water etc.

  3. The hunt for the last respondent : nonresponse in sample surveys

    NARCIS (Netherlands)

    Stoop, I.A.L.


    The Hunt for the Last Respondent has been inspired by concerns about the possibly detrimental effect of nonresponse on the accuracy of survey outcomes, as response rates are generally considered to be the most important criterion of survey quality, and the Netherlands is notorious for its low respon

  4. Serial Killers: Academic Libraries Respond to Soaring Costs. (United States)

    McCarthy, Paul


    Discusses ways in which academic libraries are responding to rising costs of serials. Topics addressed include pricing by publishers; the effect of journal cancellations on research activities; interlibrary loans and document delivery services; coordinated cancelling; electronic journals; and experiences at the University of Arizona. (LRW)

  5. Hospital-Based First Responder Mass Prophylaxis Plan (United States)


    only: Date of last menstrual period: __________ Are you pregnant: Yes No mm/dd/yy Are you breastfeeding : Yes No Do you use birth...Recommendations The artificialities of a full-scale exercise allowed for the large number of first responders to be prophylaxed but did not exhibit

  6. Investigating prosodic relations between initiating and responding laughs

    NARCIS (Netherlands)

    Truong, Khiet P.; Trouvain, Jürgen


    In dialogue, it is not uncommon for people to laugh together. This joint laughter often results in overlapping laughter, consisting of an initiating laugh (the first one), and a responding laugh (the second one). In previous studies, we found that overlapping laughs are acoustically different from n

  7. Hydrologic Engineering Center (United States)

    Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

  8. NIH Clinical Centers (United States)

    Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

  9. Center for Women Veterans (United States)

    ... Aid & Attendance & Housebound Caregivers Community Living Centers (CLC) Community Nursing Homes Domiciliaries (Please contact your local VA Medical Center) Homemaker & Home Health Aid Care Hospice and Palliative Care State Veterans ...

  10. BKG Data Center (United States)

    Thorandt, Volkmar; Wojdziak, Reiner


    This report summarizes the activities and background information of the IVS Data Center for the year 2012. Included is information about functions, structure, technical equipment, and staff members of the BKG Data Center.

  11. Day Care Centers (United States)

    Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

  12. Poison Control Centers (United States)

    ... 1222 immediately. Name State American Association of Poison Control Centers Address AAPCC Central Office NOT A POISON ... not for emergency use. Arkansas ASPCA Animal Poison Control Center Address 1717 S. Philo Road, Suite 36 Urbana, ...

  13. Center of Attention. (United States)

    Coffey, J. Steven; Wood-Steed, Ruth


    Illustrates how college and university student centers are becoming the institution's marketing tools. Explores how the Millennium Center at the University of Missouri in St. Louis exemplifies this new trend. (GR)

  14. RSW Cell Centered Grids (United States)

    National Aeronautics and Space Administration — New cell centered grids are generated to complement the node-centered ones uploaded. Six tarballs containing the coarse, medium, and fine mixed-element and pure tet....


    Federal Laboratory Consortium — The Maryland Robotics Center is an interdisciplinary research center housed in the Institute for Systems Research (link is external)within the A. James Clark School...

  16. National Rehabilitation Information Center (United States)

    ... including News and Notes) Welcome to the National Rehabilitation Information Center! We are conducting improvements to the ... experience. We apologize for any inconvenience The National Rehabilitation Information Center ( NARIC ) is the library of the ...


    Federal Laboratory Consortium — The Maryland Robotics Center is an interdisciplinary research center housed in the Institute for Systems Research (link is external) within the A. James Clark School...

  18. Automating the Media Center. (United States)

    Holloway, Mary A.


    Discusses the need to develop more efficient information retrieval skills by the use of new technology. Lists four stages used in automating the media center. Describes North Carolina's pilot programs. Proposes benefits and looks at the media center's future. (MVL)

  19. Center for Functional Nanomaterials (United States)

    Federal Laboratory Consortium — The Center for Functional Nanomaterials (CFN) explores the unique properties of materials and processes at the nanoscale. The CFN is a user-oriented research center...

  20. Sleeping birds do not respond to predator odour.

    Directory of Open Access Journals (Sweden)

    Luisa Amo

    Full Text Available BACKGROUND: During sleep animals are relatively unresponsive and unaware of their environment, and therefore, more exposed to predation risk than alert and awake animals. This vulnerability might influence when, where and how animals sleep depending on the risk of predation perceived before going to sleep. Less clear is whether animals remain sensitive to predation cues when already asleep. METHODOLOGY/PRINCIPAL FINDINGS: We experimentally tested whether great tits are able to detect the chemical cues of a common nocturnal predator while sleeping. We predicted that birds exposed to the scent of a mammalian predator (mustelid twice during the night would not go into torpor (which reduces their vigilance and hence would not reduce their body temperature as much as control birds, exposed to the scent of another mammal that does not represent a danger for the birds (rabbit. As a consequence of the higher body temperature birds exposed to the scent of a predator are predicted to have a higher resting metabolic rate (RMR and to lose more body mass. In the experiment, all birds decreased their body temperature during the night, but we did not find any influence of the treatment on body temperature, RMR, or body mass. CONCLUSIONS/SIGNIFICANCE: Our results suggest that birds are not able to detect predator chemical cues while sleeping. As a consequence, antipredatory strategies taken before sleep, such as roosting sites inspection, may be crucial to cope with the vulnerability to predation risk while sleeping.

  1. Sleeping Birds Do Not Respond to Predator Odour

    NARCIS (Netherlands)

    Amo, Luisa; Caro, Samuel P.; Visser, Marcel E.


    Background: During sleep animals are relatively unresponsive and unaware of their environment, and therefore, more exposed to predation risk than alert and awake animals. This vulnerability might influence when, where and how animals sleep depending on the risk of predation perceived before going to

  2. Sleeping birds do not respond to predator odour

    NARCIS (Netherlands)

    Amo, L.; Caro, S.P.; Visser, M.E.


    Background: During sleep animals are relatively unresponsive and unaware of their environment, and therefore, more exposed to predation risk than alert and awake animals. This vulnerability might influence when, where and how animals sleep depending on the risk of predation perceived before going to

  3. Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy

    DEFF Research Database (Denmark)

    Enk, C D; Nasereddin, A; Alper, R


    application of a thick layer of 16% methyl aminolaevulinate and 30-min occlusion, the lesions were exposed to daylight for 2·5 h. Treatment sessions were repeated at weekly intervals until clinical and microbiological cure. Control lesions were either treated with cryotherapy or left untreated. RESULTS...

  4. Data center cooling method

    Energy Technology Data Exchange (ETDEWEB)

    Chainer, Timothy J.; Dang, Hien P.; Parida, Pritish R.; Schultz, Mark D.; Sharma, Arun


    A method aspect for removing heat from a data center may use liquid coolant cooled without vapor compression refrigeration on a liquid cooled information technology equipment rack. The method may also include regulating liquid coolant flow to the data center through a range of liquid coolant flow values with a controller-apparatus based upon information technology equipment temperature threshold of the data center.

  5. An alternative framework for responding to the amphibian crisis (United States)

    Muths, Erin L.; Fisher, Robert N.


    Volumes of data illustrate the severity of the crisis affecting amphibians, where > 32% of amphibians worldwide are threatened with declining populations. Although there have been isolated victories, the current approach to the issue is unsuccessful. We suggest that a radically different approach, something akin to human emergency response management (i.e. the Incident Command System), is one alternative to addressing the inertia and lack of cohesion in responding to amphibian issues. We acknowledge existing efforts and the useful research that has been conducted, but we suggest that a change is warranted and that the identification of a new amphibian chytrid provides the impetus for such a change. Our goal is to recognize that without a centralized effort we (collectively) are likely to fail in responding to this challenge.

  6. Respondent-Driven Sampling – Testing Assumptions: Sampling with Replacement

    Directory of Open Access Journals (Sweden)

    Barash Vladimir D.


    Full Text Available Classical Respondent-Driven Sampling (RDS estimators are based on a Markov Process model in which sampling occurs with replacement. Given that respondents generally cannot be interviewed more than once, this assumption is counterfactual. We join recent work by Gile and Handcock in exploring the implications of the sampling-with-replacement assumption for bias of RDS estimators. We differ from previous studies in examining a wider range of sampling fractions and in using not only simulations but also formal proofs. One key finding is that RDS estimates are surprisingly stable even in the presence of substantial sampling fractions. Our analyses show that the sampling-with-replacement assumption is a minor contributor to bias for sampling fractions under 40%, and bias is negligible for the 20% or smaller sampling fractions typical of field applications of RDS.

  7. Correlates of cyberbullying and how school nurses can respond. (United States)

    Van Ouytsel, Joris; Walrave, Michel; Vandebosch, Heidi


    Cyberbullying is one of many online risks that affect an increasing number of children and teenagers. This form of abuse often occurs under the radar of adults as it usually takes place outside of school and away from adult supervision. Moreover, bystanders and victims are often reluctant to report what they have experienced. School nurses might be among the first to witness the real-life consequences of this virtual behavior, as involvement in cyberbullying is often correlated with psychological and behavioral problems. For this reason, school nurses should know how to recognize the warning signs so that they can respond and intervene appropriately. This article provides a discussion of what cyberbullying is and a summary of research on factors associated with cyberbullying, in terms of both victimization and perpetration. It also provides school nurses with evidence-based strategies for responding effectively.

  8. Preparedness and training in staff responding to a burns disaster. (United States)

    May, Jolyon; Colbert, David; Rea, Suzanne; Wood, Fiona; Nara-Venkata, Raghav

    Effective disaster response is preceded by effective disaster planning, and insufficient staff training has been identified as a problem in the preparation of hospitals for major incidents. Despite this, little is known about the exact levels of training doctors and nurses responding to a disaster receive. The authors conducted a six-question survey delivered to staff involved in the hospital response to a burns mass disaster in Western Australia. The occupation, and also the clinical area in which the respondent worked, influenced the level of training they received. Training in formal disaster courses and practical exercises in mock disaster situations needs to be ongoing for all staff members for correct implantation of disaster plans. Findings may be useful in informing current and future efforts to improve hospital preparedness.

  9. Integration of Training Civilian and Military Disaster Responders (United States)


    TRAINING CIVILIAN AND MILITARY DISASTER RESPONDERS by Leonard H. Guercia, Jr. September 2011 Thesis Advisor: Sam Clovis Second Reader...Guercia, Jr. Approved by: Sam Clovis Thesis Advisor William Austin Second Reader Harold A. Trinkunas, PhD Chair, Department...admiration. Their efforts transformed me from a tentative new student to a well-written professional. I want to extend a special thanks to Dr. Clovis

  10. Sense and Respond Logistics: Integrating Prediction, Responsiveness, and Control Capabilities (United States)


    architecture (Cougaar) platform . Cougaar is a Java-based architecture for the con- struction of large-scale distributed agent-based applications.32...mentation of a robust S&RCS capability will require AL applications on some judiciously chosen existing weapon system platforms , neces- sitating extensive...negotiation) as part of eCommerce applications being achieved by 2007. In the general opinion of AgentLink’s respondents, as well as our technology

  11. Responding to Prenatal Disclosure of Past Sexual Abuse



    The American College of Obstetricians and Gynecologists recommends that physicians elicit a sexual abuse and rape trauma history for every patient. Yet in practice, physicians may still struggle to understand how best to obtain this history and what clinical obligations arise when a physician inquires and a woman discloses a remote history of childhood or adult sexual trauma during the course of her prenatal care. This commentary offers a practical strategy for responding to sexual trauma dis...

  12. Systemic sclerosis with portal hypertensive ascites responded to corticosteroid treatment

    Institute of Scientific and Technical Information of China (English)

    LENG Xiao-mei; SUN Xue-feng; ZHANG Xuan; ZHANG Wen; LI Meng-tao; ZENG Xiao-feng


    We describe a case of systemic sclerosis (SSc) complicated with portal hypertensive ascites which did not improve with diuretics and ascitic drainage.When corticosteroid added,her ascites diminished dramatically.Though portal hypertension can be imputed to other causes,such as polycystic liver in this case,it can occur in limited SSc with positive anti-centromere antibody and respond to corticosteroid treatment.

  13. Respondent-Driven Sampling: An Assessment of Current Methodology*


    Gile, Krista J.; Handcock, Mark S.


    Respondent-Driven Sampling (RDS) employs a variant of a link-tracing network sampling strategy to collect data from hard-to-reach populations. By tracing the links in the underlying social network, the process exploits the social structure to expand the sample and reduce its dependence on the initial (convenience) sample. The primary goal of RDS is typically to estimate population averages in the hard-to-reach population. The current estimates make strong assumptions in order to treat the dat...

  14. Logistics Transformation through Sense-and-Respond Logistics Network



    Proceedings Paper (for Acquisition Research Program) Commercial and military logistics continue to evolve from amassing supplies, through supply chain management, to (more recently) sense-and-respond networks. The realization that ''demand-pull'' is inherently more efficient than a ''supply-push'' strategy propels the migration from supply chains to demand networks. Major commercial enterprises in the United States and abroad have already transformed their supply chains to include Sense-...

  15. Cities and Climate Change : Responding to an Urgent Agenda


    Hoornweg, Daniel; Freire, Mila; Marcus J. Lee; Bhada-Tata, Perinaz; Yuen, Belinda


    The 5th urban research symposium on cities and climate change responding to an urgent agenda, held in Marseille in June 2009, sought to highlight how climate change and urbanization are converging to create one of the greatest challenges of our time. Cities consume much of the world's energy, and thus produce much of the world's greenhouse gas emissions. Yet cities, to varying extents, are...

  16. The Northeast Climate Science Center (United States)

    Ratnaswamy, M. J.; Palmer, R. N.; Morelli, T.; Staudinger, M.; Holland, A. R.


    The Department of Interior Northeast Climate Science Center (NE CSC) is part of a federal network of eight Climate Science Centers created to provide scientific information, tools, and techniques that managers and other parties interested in land, water, wildlife and cultural resources can use to anticipate, monitor, and adapt to climate change. Recognizing the critical threats, unique climate challenges, and expansive and diverse nature of the northeast region, the University of Massachusetts Amherst, College of Menominee Nation, Columbia University, Marine Biological Laboratory, University of Minnesota, University of Missouri Columbia, and University of Wisconsin-Madison have formed a consortium to host the NE CSC. This partnership with the U.S. Geological Survey climate science center network provides wide-reaching expertise, resources, and established professional collaborations in both climate science and natural and cultural resources management. This interdisciplinary approach is needed for successfully meeting the regional needs for climate impact assessment, adaptive management, education, and stakeholder outreach throughout the northeast region. Thus, the NE CSC conducts research, both through its general funds and its annual competitive award process, that responds to the needs of natural resource management partners that exist, in part or whole, within the NE CSC bounds. This domain includes the North Atlantic, Upper Midwest and Great Lakes, Eastern Tallgrass and Big Rivers, and Appalachian Landscape Conservation Cooperatives (LCCs), among other management stakeholders. For example, researchers are developing techniques to monitor tree range dynamics as affected by natural disturbances which can enable adaptation of projected climate impacts; conducting a Designing Sustainable Landscapes project to assess the capability of current and potential future landscapes in the Northeast to provide integral ecosystems and suitable habitat for a suite of

  17. Ganirelix for luteolysis in poor responder patients undergoing IVF treatment: a Scandinavian multicenter 'extended pilot study'

    DEFF Research Database (Denmark)

    Nilsson, Lena; Andersen, A.N.; Lindenberg, Svend;


    To enhance oocyte yield and pregnancy outcome in poor responder women undergoing IVF treatment, daily low dose GnRH antagonist administration was given during the late luteal phase to induce luteolysis and possibly secure a more synchronous cohort of recruitable follicles. An open extended pilot...... study in four Scandinavian fertility centers was done including 60 patients. Poor response was defined as when 2000 IU FSH. GnRH antagonist (ganirelix) was given, 0.25 mg s.c. daily, from days 3 to 5...... before expected start of menstruation and continued for 4-7 days. On cycle day 2-3 a starting dose of rFSH (300-400 IU/day) was given. At a leading follicle diameter of 14 mm, ganirelix administration was resumed until final oocyte maturation was induced with 10,000 IU hCG. GnRH antagonist only...

  18. Limited transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli.

    Directory of Open Access Journals (Sweden)

    Damon W Ellison

    Full Text Available Rickettsiae are strict obligate intracellular pathogens that alternate between arthropod and mammalian hosts in a zoonotic cycle. Typically, pathogenic bacteria that cycle between environmental sources and mammalian hosts adapt to the respective environments by coordinately regulating gene expression such that genes essential for survival and virulence are expressed only upon infection of mammals. Temperature is a common environmental signal for upregulation of virulence gene expression although other factors may also play a role. We examined the transcriptional responses of Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, to a variety of environmental signals expected to be encountered during its life cycle. R. rickettsii exposed to differences in growth temperature (25 degrees C vs. 37 degrees C, iron limitation, and host cell species displayed nominal changes in gene expression under any of these conditions with only 0, 5, or 7 genes, respectively, changing more than 3-fold in expression levels. R. rickettsii is not totally devoid of ability to respond to temperature shifts as cold shock (37 degrees C vs. 4 degrees C induced a change greater than 3-fold in up to 56 genes. Rickettsiae continuously occupy a relatively stable environment which is the cytosol of eukaryotic cells. Because of their obligate intracellular character, rickettsiae are believed to be undergoing reductive evolution to a minimal genome. We propose that their relatively constant environmental niche has led to a minimal requirement for R. rickettsii to respond to environmental changes with a consequent deletion of non-essential transcriptional response regulators. A minimal number of predicted transcriptional regulators in the R. rickettsii genome is consistent with this hypothesis.

  19. Neonatal Extracorporeal Membrane Oxygenation Devices, Techniques and Team Roles: 2011 Survey Results of the United States’ Extracorporeal Life Support Organization Centers


    Lawson, Scott; Ellis, Cory; Butler, Katie; McRobb, Craig; Mejak, Brian


    In early 2011, surveys of active Extracorporeal Life Support Organization (ELSO) centers within the United States were conducted by electronic mail regarding neonatal Extracorporeal Membrane Oxygenation (ECMO) equipment and professional staff. Seventy-four of 111 (67%) U.S. centers listed in the ELSO directory as neonatal centers responded to the survey. Of the responding centers, 53% routinely used roller pumps for neonatal ECMO, 15% reported using centrifugal pumps and 32% reported using a ...

  20. A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    LENUS (Irish Health Repository)

    Brown, Catherine M


    Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1, 2, and 12 months. Responses were (1) a titer >100 mIU\\/mL = patient immune, (2) a titer level 10-99 mIU\\/mL = give a booster dose and recheck level 2 months later, and (3) 0 ≤ 10 mIU\\/mL = repeat vaccination course using a different vaccine, Engerix-B. We compared responder groups in terms of titer levels for each vaccine and variables including age, gender, serum albumin, parathyroid hormone (PTH), calcium, phosphate, hemoglobin, years on dialysis, and type of dialysis access. Of the 176 patients who received the first vaccine course, 71 patients achieved immunity, that is, 40% uptake for the first vaccine. Of the 105 who failed, 72 received the second vaccine with 46 responders, that is, 64% uptake for the second vaccine. Overall, 143 of the 176 patients who entered the vaccination program completed the protocol with 117 achieving immunity, representing an 82% success rate. The only variable overall to show significance in achieving seroconversion was serum albumin (p = 0.03). Using a two-vaccine protocol, hepatitis B vaccination response was high in our population of end-stage renal disease patients.

  1. A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    LENUS (Irish Health Repository)

    Brown, Catherine M


    Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 microg intramuscularly using a four-dose schedule at 0, 1, 2, and 12 months. Responses were (1) a titer >100 mIU\\/mL = patient immune, (2) a titer level 10-99 mIU\\/mL = give a booster dose and recheck level 2 months later, and (3) 0 <\\/= 10 mIU\\/mL = repeat vaccination course using a different vaccine, Engerix-B. We compared responder groups in terms of titer levels for each vaccine and variables including age, gender, serum albumin, parathyroid hormone (PTH), calcium, phosphate, hemoglobin, years on dialysis, and type of dialysis access. Of the 176 patients who received the first vaccine course, 71 patients achieved immunity, that is, 40% uptake for the first vaccine. Of the 105 who failed, 72 received the second vaccine with 46 responders, that is, 64% uptake for the second vaccine. Overall, 143 of the 176 patients who entered the vaccination program completed the protocol with 117 achieving immunity, representing an 82% success rate. The only variable overall to show significance in achieving seroconversion was serum albumin (p = 0.03). Using a two-vaccine protocol, hepatitis B vaccination response was high in our population of end-stage renal disease patients.

  2. Transportation Technical Environmental Information Center index

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, C. A.; Foley, J. T.


    In an effort to determine the environmental intensities to which energy materials in transit may be exposed, a Data Center of technical environmental information has been established by Sandia National Laboratories, Division 5523, for the DOE Office of Transportation Fuel Storage. This document is an index which can be used to request data of interest. Access to the information held is not limited to Sandia personnel. The purpose of the Transportation Technical Environmental Information Center is to collect, analyze, store, and make available descriptions of the environment of transportation expressed in engineering terms. The data stored in the Center are expected to be useful in a variety of transportation related analyses. Formulations of environmental criteria for shipment of cargo, risk assessments, and detailed structural analyses of shipping containers are examples where these data have been applied. For purposes of indexing and data retrieval, the data are catalogued under two major headings: Normal and Abnormal Environments.

  3. Responding to Terrorist Incidents in Your Community: Flammable-Liquid Fire Fighting Techniques for Municipal and Rural Firefighters

    Energy Technology Data Exchange (ETDEWEB)

    Denise Baclawski


    The University of Nevada, Reno Fire Science Academy (FSA) applied for grant funding to develop and deliver programs for municipal, rural, and volunteer firefighters. The FSA specializes in preparing responders for a variety of emergency events, including flammable liquid fires resulting from accidents, intentional acts, or natural disasters. Live fire training on full scale burnable props is the hallmark of FSA training, allowing responders to practice critical skills in a realistic, yet safe environment. Unfortunately, flammable liquid live fire training is often not accessible to municipal, rural, or volunteer firefighters due to limited department training budgets, even though most department personnel will be exposed to flammable liquid fire incidents during the course of their careers. In response to this training need, the FSA developed a course during the first year of the grant (Year One), Responding to Terrorist Incidents in Your Community: Flammable-Liquid Fire Fighting Techniques for Municipal and Rural Firefighters. During the three years of the grant, a total of 2,029 emergency responders received this training. In Year Three, two new courses, a train-the-trainer for Responding to Terrorist Incidents in Your Community and Management of Large-Scale Disasters for Public Officials were developed and pilot tested during the Real-World Disaster Management Conference held at the FSA in June of 2007. Two research projects were conducted during Years Two and Three. The first, conducted over a two year period, evaluated student surveys regarding the value of the flammable liquids training received. The second was a needs assessment conducted for rural Nevada. Both projects provided important feedback and a basis for curricula development and improvements.

  4. Value correlates of the motivations to respond without prejudice / Correlatos valorativos das motivações para responder sem preconceito

    Directory of Open Access Journals (Sweden)

    Valdiney V. Gouveia


    Full Text Available The current study aimed at establishing to what extent both internal and external motivations to respond without prejudice towards Blacks would correlate with human values. As many as 308 subjects from João Pessoa – comprising high school and university students as well as individuals from the community as a whole – were considered. The Basic Values Questionnaire, the Impression Management Scale and the Scale of Internal and External Motivation to Respond without Prejudice, and also demographic questions were applied. Results showed that the internal motivation was positively correlated with the suprapersonal values, specifically maturity, beauty and knowledge. Moreover, the external motivation did correlate, predominantly, with the achievement values, specifically those of prestige and privacy. Such results are in line with those found in the literature, which indicate the opposition between egalitarianism (suprapersonal vs. protestant ethic (achievement values so as to explicate the prejudice and the motivations that would prevent such attitude.

  5. Symptomatic response to blocked and unblocked pentagastrin stimulation in functional dyspepsia - Comparison of responders and non-responders to omeprazole identified in a single-subject trial model

    DEFF Research Database (Denmark)

    Madsen, L.G.; Bytzer, P.


    hypothesized that RSD trial responders and non-responders would react differently to gastric acid stimulation. Development of epigastric pain was expected in RSD trial responders after pentagastrin stimulation during placebo treatment, but not during omeprazole treatment. In non-responders, epigastric pain...... was expected not to be influenced by gastric acid stimulation or type of treatment. Methods: Nineteen patients were evaluated. Symptomatic response to pentagastrin (6 mu g/kg) was assessed twice in each patient following placebo and omeprazole (40 mg bid) treatment in a randomized, double-blind, cross...... but not during omeprazole treatment. Results: The acid provocation test was positive in 43% (3/7) of responders compared to only 17% (2/12) non-responders. VAS-score changes showed trends towards a more pronounced symptom reduction during omeprazole treatment in responders compared to non-responders. Conclusion...

  6. Flexural buckling of fire exposed aluminium columns

    NARCIS (Netherlands)

    Maljaars, J.; Twilt, L.; Soetens, F.


    In order to study buckling of fire exposed aluminium columns, a finite element model is developed. The results of this model are verified with experiments. Based on a parametric study with the finite element model, it is concluded that the simple calculation model for flexural buckling of fire expos

  7. Interphase cytogenetics of workers exposed to benzene

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, L.; Wang, Yunxia; Venkatesh, P. [Univ. of California, Berkeley, CA (United States)] [and others


    Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. In previous studies, FISH has been used to demonstrate that the benzene metabolites hydroquinone and 1,2,4-benzenetriol induce aneuploidy of chromosomes 7 and 9 in cultures of human cells. In the present study, we used an interphase FISH procedure to perform cytogenetic analyses on the blood cells of 43 workers exposed to benzene (median=31 ppm, 8-hr time-weighted average) and 44 matched controls from Shanghai, China. High benzene exposure (>31 ppm, n=22) increased the hyperdiploid frequency of chromosome 9 (p<0.01), but lower exposure (<31 ppm, n=21) did not. Trisomy 9 was the major form of benzene-induced hyperdiploidy. The level of hyperdiploidy in exposed workers correlated with their urinary phenol level (r= 0.58, p < 0.0001), a measure of internal benzene close. A significant correlation was also found between hyperdiploicly and decreased absolute lymphocyte count, an indicator of benzene hematotoxicity, in the exposed group (r=-0.44, p=0.003) but not in controls (r=-0.09, P=0.58). These results show that high benzene exposure induces aneuploidy of chromosome 9 in nondiseased individuals, with trisomy being the most prevalent form. They further highlight the usefulness of interphase cytogenetics and FISH for the rapid and sensitive detection of aneuploidy in exposed human populations. 35 refs., 3 figs., 2 tabs.

  8. Rural Canadian Youth Exposed to Physical Violence (United States)

    Laye, Adele M.; Mykota, David B.


    Exposure to physical violence is an unfortunate reality for many Canadian youth as it is associated with numerous negative psychosocial effects. The study aims to assist in understanding resilience in rural Canadian youth exposed to physical violence. This is accomplished by identifying the importance of protective factors, as measured by the…

  9. Expose Mechanical Engineering Students to Biomechanics Topics (United States)

    Shen, Hui


    To adapt the focus of engineering education to emerging new industries and technologies nationwide and in the local area, a biomechanics module has been developed and incorporated into a mechanical engineering technical elective course to expose mechanical engineering students at ONU (Ohio Northern University) to the biomedical engineering topics.…

  10. Exposing the Mathematical Wizard: Approximating Trigonometric Functions (United States)

    Gordon, Sheldon P.


    For almost all students, what happens when they push buttons on their calculators is essentially magic, and the techniques used are seemingly pure wizardry. In this article, the author draws back the curtain to expose some of the mathematics behind computational wizardry and introduces some fundamental ideas that are accessible to precalculus…

  11. Mitochondrial DNA deletion percentage in sun exposed and non sun exposed skin. (United States)

    Powers, Julia M; Murphy, Gillian; Ralph, Nikki; O'Gorman, Susan M; Murphy, James E J


    The percentages of mitochondrial genomes carrying the mtDNA(3895) and the mtDNA(4977) (common) deletion were quantified in sun exposed and non sun exposed skin biopsies, for five cohorts of patients varying either in sun exposure profile, age or skin cancer status. Non-melanoma skin cancer diagnoses are rising in Ireland and worldwide [12] but most risk prediction is based on subjective visual estimations of sun exposure history. A quantitative objective test for pre-neoplastic markers may result in better adherence to sun protective behaviours. Mitochondrial DNA (mtDNA) is known to be subject to the loss of a significant proportion of specific sections of genetic code due to exposure to ultraviolet light in sunlight. Although one such deletion has been deemed more sensitive, another, called the mtDNA(4977) or common deletion, has proved to be a more useful indicator of possible risk in this study. Quantitative molecular analysis was carried out to determine the percentage of genomes carrying the deletion using non sun exposed and sun exposed skin biopsies in cohorts of patients with high or low sun exposure profiles and two high exposure groups undergoing treatment for NMSC. Results indicate that mtDNA deletions correlate to sun exposure; in groups with high sun exposure habits a significant increase in deletion number in exposed over non sun exposed skin occurred. An increase in deletion percentage was also seen in older cohorts compared to the younger group. The mtDNA(3895) deletion was detected in small amounts in exposed skin of many patients, the mtDNA(4977) common deletion, although present to some extent in non sun exposed skin, is suggested to be the more reliable and easily detected marker. In all cohorts except the younger group with relatively lower sun exposure, the mtDNA(4977) deletion was more frequent in sun exposed skin samples compared to non-sun exposed skin.

  12. Proposed Construction of the Madera County Educational Center in the State Center Community College District. A Report to the Governor and Legislature in Response to a Request from the Board of Governors of the California Community Colleges. (United States)

    California State Postsecondary Education Commission, Sacramento.

    In this report, the California Postsecondary Education Commission responds to a request by the Chancellor of the California Community Colleges to review the need for and location of a new educational center, the Madera County Educational Center, north of Fresno within the State Center Community College District. The report contains nine…

  13. Called to respond: The potential of unveiling hiddens

    Directory of Open Access Journals (Sweden)

    Alison L Black


    Full Text Available Interested in exploring how personal stories and aesthetic modes of representing experiences can nudge open academic and educational spaces, this article/collection of particles seeks to document our encounters of being affected and called to respond to things the other has written and represented. As a way of engaging with questions about what research and research data might be and become, our attention has been drawn to stories and images from our lives that we have not shaken off – and to how, as we have opened these to the other, making once private moments public, our hiddens have morphed tenderly into a shared knowing and being. As we have acted on the call we have felt to respond we have found ourselves entering spaces of collaboration, communion, contemplation, and conversation – spaces illuminated by what we have not been able to – and cannot – set aside. Using visual and poetic materials we explore heartfelt and heartbroken aspects of our educational worlds and lives, to be present with each other and our (reemerging personal and professional meanings. We see the shared body (of work, of writing, of image that develops from the taking of brave steps and the risky slipping off of academic masks and language, as a manifestation of the trusted and nurturing spaces that can be generated through collaborative opportunities to gather together. These steps towards unveiling hiddens are producing in us and of us a friendship, fluency, and fluidity as we write new ways of becoming. In turn, we hope the uncovering and revealing of our dialogue in the public gathering of this journal might supports readers’ telling of their own life stories through what calls them to respond.

  14. Test Control Center exhibit (United States)


    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  15. Relativistic Guiding Center Equations

    Energy Technology Data Exchange (ETDEWEB)

    White, R. B. [PPPL; Gobbin, M. [Euratom-ENEA Association


    In toroidal fusion devices it is relatively easy that electrons achieve relativistic velocities, so to simulate runaway electrons and other high energy phenomena a nonrelativistic guiding center formalism is not sufficient. Relativistic guiding center equations including flute mode time dependent field perturbations are derived. The same variables as used in a previous nonrelativistic guiding center code are adopted, so that a straightforward modifications of those equations can produce a relativistic version.

  16. Socially desirable responding in Chinese university students: denial and enhancement? (United States)

    Li, Feng; Li, Yongjuan; Wang, Yong


    This study examined the Balanced Inventory of Desirable Responding (BIDR) with one-, two-, three-, and four-dimensional models and tested the BIDR's discriminant validity with personality variables. A confirmatory and exploratory factor analysis of responses from 600 Chinese university students (314 men, 282 women, 4 missing; M age=20.0 yr.) provided results indicating that the four-factor model fit the data best; i.e., self-deception and impression management split into denial and enhancement. The Denial and Enhancement subscales with personality variables show significant differences, confirming the four-factor model. The cultural differences as a possible reason for the split were discussed.

  17. Responding to and treating negative interpersonal processes in suicidal depression. (United States)

    Stellrecht, Nadia E; Joiner, Thomas E; Rudd, M David


    The authors discuss the active engagement of suicidally depressed individuals in several interpersonal processes that elicit the rejection of others and withdrawal of interpersonal support. In addition, such processes may increase future risk for suicidal behavior. These processes include ways in which suicidal individuals group themselves (e.g., assortative relationship formation) and relate to others (e.g., help negation, negative feedback seeking, excessive reassurance seeking). Implications of these behaviors for the therapeutic setting are discussed, as well as potential ways to respond to and treat them.

  18. Application of PLM processes to respond to mechanical SMEs needs

    CERN Document Server

    Duigou, Julien Le; Perry, Nicolas; Delplace, Jean-Charles


    PLM is today a reality for mechanical SMEs. Some companies implement PLM systems very well but others have more difficulties. This paper aims to explain why some SMEs do not success to integrated PLM systems analyzing the needs of mechanical SMEs, the processes to implement to respond to those needs and the actual PLM software functionalities. The proposition of a typology of those companies and the responses of those needs by PLM processes will be explain through the applications of a demonstrator applying appropriate generic data model and modelling framework.

  19. Great Lakes Science Center (United States)

    Federal Laboratory Consortium — Since 1927, Great Lakes Science Center (GLSC) research has provided critical information for the sound management of Great Lakes fish populations and other important...

  20. Small Business Development Center (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  1. Advanced Simulation Center (United States)

    Federal Laboratory Consortium — The Advanced Simulation Center consists of 10 individual facilities which provide missile and submunition hardware-in-the-loop simulation capabilities. The following...

  2. Environmental Modeling Center (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  3. Surgery center joint ventures. (United States)

    Zasa, R J


    Surgery centers have been accepted as a cost effective, patient friendly vehicle for delivery of quality ambulatory care. Hospitals and physician groups also have made them the vehicles for coming together. Surgery centers allow hospitals and physicians to align incentives and share benefits. It is one of the few types of health care businesses physicians can own without anti-fraud and abuse violation. As a result, many surgery center ventures are now jointly owned by hospitals and physician groups. This article outlines common structures that have been used successfully to allow both to own and govern surgery centers.

  4. Test Control Center (TCC) (United States)

    Federal Laboratory Consortium — The Test Control Center (TCC) provides a consolidated facility for planning, coordinating, controlling, monitoring, and analyzing distributed test events. ,The TCC...

  5. Data Center at NICT (United States)

    Ichikawa, Ryuichi; Sekido, Mamoru


    The Data Center at the National Institute of Information and Communications Technology (NICT) archives and releases the databases and analysis results processed at the Correlator and the Analysis Center at NICT. Regular VLBI sessions of the Key Stone Project VLBI Network were the primary objective of the Data Center. These regular sessions continued until the end of November 2001. In addition to the Key Stone Project VLBI sessions, NICT has been conducting geodetic VLBI sessions for various purposes, and these data are also archived and released by the Data Center.

  6. Chemical Security Analysis Center (United States)

    Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...

  7. Airline Operation Center Workstation (United States)

    Department of Transportation — The Airline Operation Center Workstation (AOC Workstation) represents equipment available to users of the National Airspace system, outside of the FAA, that enables...

  8. Center for Deployment Psychology (United States)

    Federal Laboratory Consortium — The Center for Deployment Psychology was developed to promote the education of psychologists and other behavioral health specialists about issues pertaining to the...

  9. Electron Microscopy Center (EMC) (United States)

    Federal Laboratory Consortium — The Electron Microscopy Center (EMC) at Argonne National Laboratory develops and maintains unique capabilities for electron beam characterization and applies those...

  10. Audio Visual Center (United States)

    Federal Laboratory Consortium — The Audiovisual Services Center provides still photographic documentation with laboratory support, video documentation, video editing, video duplication, photo/video...

  11. NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 7:Summary report to phase 2 respondents including frequency distributions (United States)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.


    Phase 2 of the four phase NASA/DoD Aerospace Knowledge Diffusion Research Project was undertaken to study the transfer of scientific and technical information (STI) from government to the aerospace industry and the role of librarians and technical information specialists in the transfer process. Data was collected through a self-administered mailback questionnaire. Libraries identified as holding substantial aerospace or aeronautical technical report collections were selected to receive the questionnaires. Within each library, the person responsible for the technical report was requested to answer the questionnaire. Questionnaires were returned from approx. 68 pct. of the libraries. The respondents indicated that scientists and engineer are not aware of the services available from libraries/technical information centers and that scientists and engineers also under-utilized their services. The respondents also indicated they should be more involved in the process.

  12. 78 FR 22794 - World Trade Center Health Program; Certification of Breast Cancer in WTC Responders and Survivors... (United States)


    ... evidence has been conflicting. PCBs and some other substances at the WTC site are endocrine disruptors..., and could plausibly be affected by endocrine disruptors. A recent study found that PCBs enhanced...

  13. Exposing variation to aid climate change risk assessment (United States)

    Smith, M. J.; Purves, D. W.; Joppa, L. N.; Emmott, S.; Lyutsarev, V.; Bishop, C. M.; Palmer, P. I.; Calderhead, B.; Vanderwel, M. C.


    Considerable efforts to quantify different sources of variation in climate change projections (some might say uncertainty) have led to a welcome set of additional information on which to base confidence about what and how different futures might unfold and how different types of mediating efforts might affect the future. Quantifying the impacts of these different sources of variation on key climate change projection metrics should be used in part to guide future model development efforts. I will report on several of my team's recent research projects to better quantify and assess the importance of different sources of variation. I will show how we use inference techniques to estimate parameter uncertainty in land and marine carbon components of earth system models by comparing them with observational evidence and show how we propagate such uncertainty to better assess how such systems might respond to climate change and quantify the impact of reducing uncertainty for different applications. I will also show how we use such techniques on simulation models themselves to identify key sources of variation in their predictions: helping to pinpoint important focal areas for model improvement. Lastly, I will show a new software prototype being designed to enable any user to view climate model projections alongside historical and recent observational evidence while, importantly, also exposing some of the variation / uncertainty in the reported information.

  14. Can ecological history influence response to pollutants? Transcriptomic analysis of Manila clam collected in different Venice lagoon areas and exposed to heavy metal. (United States)

    Milan, Massimo; Matozzo, Valerio; Pauletto, Marianna; Di Camillo, Barbara; Giacomazzo, Matteo; Boffo, Luciano; Binato, Giovanni; Marin, Maria Gabriella; Patarnello, Tomaso; Bargelloni, Luca


    Chronic exposure to environmental pollutants can exert strong selective pressures on natural populations, favoring the transmission over generations of traits that enable individuals to survive and thrive in highly impacted environments. The lagoon of Venice is an ecosystem subject to heavy anthropogenic impact, mainly due to the industrial activities of Porto Marghera (PM), which led to a severe chemical contamination of soil, groundwater, and sediments. Gene expression analysis on wild Manila clams collected in different Venice lagoon areas enabled to identify differences in gene expression profiles between clams collected in PM and those sampled in clean areas, and the definition of molecular signatures of chemical stress. However, it remains largely unexplored to which extent modifications of gene expression patterns persists after removing the source of contamination. It is also relatively unknown whether chronic exposure to xenobiotics affects the response to other chemical pollutants. To start exploring such issues, in the present study a common-garden experiment was coupled with transcriptomic analysis, to compare gene expression profiles of PM clams with those of clams collected in the less impacted area of Chioggia (CH) during a period under the same control conditions. Part of the two experimental groups were also exposed to copper for seven days to assess whether different "ecological history" does influence response to such pollutant. The results obtained suggest that the chronic exposure to chemical pollution generated a response at the transcriptional level that persists after removal for the contaminated site. These transcriptional changes are centered on key biological processes, such as defense against either oxidative stress or tissue/protein damage, and detoxification, suggesting an adaptive strategy for surviving in the deeply impacted environment of Porto Marghera. On the other hand, CH clams appeared to respond more effectively to copper

  15. Call center. Centrados en el cliente


    Leal-Alonso-de-Castañeda, José Enrique


    La empresa actual ha de estar preparada para responder al Cliente tal y como éste espera, porque no se busca un cliente puntual, sino un cliente fiel. La globalización de la economía y del acceso a los mercados exige que la empresa sea capaz de atraer al cliente no sólo con un servicio de calidad, sino además con una atención de calidad. La implantación de un Call Center (Centro de Atención al Cliente, Centro de Atención de Llamadas) constituye por todo ello una estrategia de negocio qu...

  16. Sport: The Liveliest Art. Diamonds Are a Publisher's Best Friend: The Baseball Mystique and Scholarly Publishing; "Take Me Out to the Ball Game...." The Importance of Archiving Sporting Activities; Telling the Story: Museums and Libraries Partner To Make Sport History Live; "I'm Not Surfing. This is My Job"; Sideline: Webliography of General Sports Sites: The Big Four; Public Libraries Step Up to the Plate: Knowing and Responding to the Needs of Our Rapidly Changing Communities; Sideline: Sports Fiction; Ten Best Sport My Public Library, in My Media Center, in My High School Library, in My Academic Library. (United States)

    Wilson, Steve; Wise, Suzanne; Koonts, Russell S.; Sumner, Jim; Meier, James R.; Gonzalez, Lena; Ruszczyk, James R.; Fiedler, Stephanie; Mayo, Kim P.; Holmes, Gerald


    Eight articles in this section focus on sports: the baseball mystique and scholarly publishing; importance of archiving sporting activities; museums and libraries partner to make sport history live; online resources for sports information; Webliography of general sports sites; public libraries responding to changing needs; sports fiction; and "ten…

  17. Sport: The Liveliest Art. Diamonds Are a Publisher's Best Friend: The Baseball Mystique and Scholarly Publishing; "Take Me Out to the Ball Game...." The Importance of Archiving Sporting Activities; Telling the Story: Museums and Libraries Partner To Make Sport History Live; "I'm Not Surfing. This is My Job"; Sideline: Webliography of General Sports Sites: The Big Four; Public Libraries Step Up to the Plate: Knowing and Responding to the Needs of Our Rapidly Changing Communities; Sideline: Sports Fiction; Ten Best Sport My Public Library, in My Media Center, in My High School Library, in My Academic Library. (United States)

    Wilson, Steve; Wise, Suzanne; Koonts, Russell S.; Sumner, Jim; Meier, James R.; Gonzalez, Lena; Ruszczyk, James R.; Fiedler, Stephanie; Mayo, Kim P.; Holmes, Gerald


    Eight articles in this section focus on sports: the baseball mystique and scholarly publishing; importance of archiving sporting activities; museums and libraries partner to make sport history live; online resources for sports information; Webliography of general sports sites; public libraries responding to changing needs; sports fiction; and…

  18. U.S. Agencies Responding to Climate Change (United States)


    Engineers® Engineer Research and Development Center Unique Circumstances of Global Climate Change (CC) • Phenomena without boundaries • Occurring over...31st Plenary Session, Bali , Indonesia, 26-28 October 2009 • 5th Assessment Report (AR5) due in 2014, 4th Assessment Report (AR4) released in 2007. US

  19. Crowdsourced Decision Support for Emergency Responders (Briefing Charts) (United States)


    destructive path” – USA Today ‣ In Boston Marathon bombing, Boston PD used Twitter to monitor public reaction, engage public, correct rumors, assist...radiological device on campus ‣ Anti-Pierce Group detonates explosive backpacks in crowds at Johnson Center ‣ Additional secondary detonations and

  20. The Sensitivity of Respondent-driven Sampling Method

    CERN Document Server

    Lu, Xin; Britton, Tom; Camitz, Martin; Kim, Beom Jun; Thorson, Anna; Liljeros, Fredrik


    Researchers in many scientific fields make inferences from individuals to larger groups. For many groups however, there is no list of members from which to take a random sample. Respondent-driven sampling (RDS) is a relatively new sampling methodology that circumvents this difficulty by using the social networks of the groups under study. The RDS method has been shown to provide unbiased estimates of population proportions given certain conditions. The method is now widely used in the study of HIV-related high-risk populations globally. In this paper, we test the RDS methodology by simulating RDS studies on the social networks of a large LGBT web community. The robustness of the RDS method is tested by violating, one by one, the conditions under which the method provides unbiased estimates. Results reveal that the risk of bias is large if networks are directed, or respondents choose to invite persons based on characteristics that are correlated with the study outcomes. If these two problems are absent, the RD...

  1. Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks. (United States)

    Flentie, Kelly; Garner, Ashley L; Stallings, Christina L


    Regulating responses to stress is critical for all bacteria, whether they are environmental, commensal, or pathogenic species. For pathogenic bacteria, successful colonization and survival in the host are dependent on adaptation to diverse conditions imposed by the host tissue architecture and the immune response. Once the bacterium senses a hostile environment, it must enact a change in physiology that contributes to the organism's survival strategy. Inappropriate responses have consequences; hence, the execution of the appropriate response is essential for survival of the bacterium in its niche. Stress responses are most often regulated at the level of gene expression and, more specifically, transcription. This minireview focuses on mechanisms of regulating transcription initiation that are required by Mycobacterium tuberculosis to respond to the arsenal of defenses imposed by the host during infection. In particular, we highlight how certain features of M. tuberculosis physiology allow this pathogen to respond swiftly and effectively to host defenses. By enacting highly integrated and coordinated gene expression changes in response to stress,M. tuberculosis is prepared for battle against the host defense and able to persist within the human population.

  2. Enabling complex genetic circuits to respond to extrinsic environmental signals. (United States)

    Hoynes-O'Connor, Allison; Shopera, Tatenda; Hinman, Kristina; Creamer, John Philip; Moon, Tae Seok


    Genetic circuits have the potential to improve a broad range of metabolic engineering processes and address a variety of medical and environmental challenges. However, in order to engineer genetic circuits that can meet the needs of these real-world applications, genetic sensors that respond to relevant extrinsic and intrinsic signals must be implemented in complex genetic circuits. In this work, we construct the first AND and NAND gates that respond to temperature and pH, two signals that have relevance in a variety of real-world applications. A previously identified pH-responsive promoter and a temperature-responsive promoter were extracted from the E. coli genome, characterized, and modified to suit the needs of the genetic circuits. These promoters were combined with components of the type III secretion system in Salmonella typhimurium and used to construct a set of AND gates with up to 23-fold change. Next, an antisense RNA was integrated into the circuit architecture to invert the logic of the AND gate and generate a set of NAND gates with up to 1168-fold change. These circuits provide the first demonstration of complex pH- and temperature-responsive genetic circuits, and lay the groundwork for the use of similar circuits in real-world applications. Biotechnol. Bioeng. 2017;9999: 1-6. © 2017 Wiley Periodicals, Inc.

  3. Wild robins (Petroica longipes) respond to human gaze. (United States)

    Garland, Alexis; Low, Jason; Armstrong, Nicola; Burns, Kevin C


    Gaze following and awareness of attentional cues are hallmarks of human and non-human social intelligence. Here, we show that the North Island robin (Petroica longipes), a food-hoarding songbird endemic to New Zealand, responds to human eyes. Robins were presented with six different conditions, in which two human experimenters altered the orientation or visibility of their body, head or eyes in relation to mealworm prey. One experimenter had visual access to the prey, and the second experimenter did not. Robins were then given the opportunity to 'steal' one of two mealworms presented by each experimenter. Robins responded by preferentially choosing the mealworm in front of the experimenter who could not see, in all conditions but one. Robins failed to discriminate between experimenters who were facing the mealworm and those who had their head turned 90° to the side. This may suggest that robins do not make decisions using the same eye visibility cues that primates and corvids evince, whether for ecological, experiential or evolutionary reasons.

  4. A Simple Evacuation Modeling and Simulation Tool for First Responders

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Daniel B [ORNL; Payne, Patricia W [ORNL


    Although modeling and simulation of mass evacuations during a natural or man-made disaster is an on-going and vigorous area of study, tool adoption by front-line first responders is uneven. Some of the factors that account for this situation include cost and complexity of the software. For several years, Oak Ridge National Laboratory has been actively developing the free Incident Management Preparedness and Coordination Toolkit (IMPACT) to address these issues. One of the components of IMPACT is a multi-agent simulation module for area-based and path-based evacuations. The user interface is designed so that anyone familiar with typical computer drawing tools can quickly author a geospatially-correct evacuation visualization suitable for table-top exercises. Since IMPACT is designed for use in the field where network communications may not be available, quick on-site evacuation alternatives can be evaluated to keep pace with a fluid threat situation. Realism is enhanced by incorporating collision avoidance into the simulation. Statistics are gathered as the simulation unfolds, including most importantly time-to-evacuate, to help first responders choose the best course of action.

  5. Community health center provider and staff's Spanish language ability and cultural awareness. (United States)

    Baig, Arshiya A; Benitez, Amanda; Locklin, Cara A; Campbell, Amanda; Schaefer, Cynthia T; Heuer, Loretta J; Lee, Sang Mee; Solomon, Marla C; Quinn, Michael T; Burnet, Deborah L; Chin, Marshall H


    Many community health center providers and staff care for Latinos with diabetes, but their Spanish language ability and awareness of Latino culture are unknown. We surveyed 512 Midwestern health center providers and staff who managed Latino patients with diabetes. Few respondents had high Spanish language (13%) or cultural awareness scores (22%). Of respondents who self-reported 76-100% of their patients were Latino, 48% had moderate/low Spanish language and 49% had moderate/low cultural competency scores. Among these respondents, 3% lacked access to interpreters and 27% had neither received cultural competency training nor had access to training. Among all respondents, Spanish skills and Latino cultural awareness were low. Respondents who saw a significant number of Latinos had good access to interpretation services but not cultural competency training. Improved Spanish-language skills and increased access to cultural competency training and Latino cultural knowledge are needed to provide linguistically and culturally tailored care to Latino patients.

  6. Funding Opportunity: Genomic Data Centers (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  7. Information Centers at NAL. (United States)

    Frank, Robyn C.


    Descriptions of the 12 specialized information centers of the National Agricultural Library (NAL) include subject coverage, information services provided, information technologies used, and staffing. The development of the Rural Information Center, a joint venture between the Extension Service and NAL to provide information services to local…

  8. Assessing the Assessment Center. (United States)

    LaRue, James


    Describes the historical use of assessment centers as staff development and promotional tools and their current use in personnel selection. The elements that constitute a true assessment center are outlined, and a discussion of the advantages and disadvantages for employers and applicants focuses on positions in library administration. (10…

  9. Handbook for Learning Centers. (United States)

    Norwalk Board of Education, CT.

    The handbook for learning centers contains guidelines, forms, and supplementary information to be used with all children identified as having a learning disability, mild retardation, or sensory deprivation in the Norwalk, Connecticut public schools. It is stressed that the learning center should provide supportive services for at least 35 minutes…

  10. Relative Lyapunov Center Bifurcations

    DEFF Research Database (Denmark)

    Wulff, Claudia; Schilder, Frank


    Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

  11. Stability of people exposed to water flows

    Directory of Open Access Journals (Sweden)

    E. Martínez-Gomariz


    Full Text Available Our cities are formed by several elements which are exposed to floods of a magnitude according to the importance of the rainfall event and the design of the urban drainage system. The most important components in the cities are the pedestrians who develop various activities during rain events. Focusing on pedestrians, the research on their stability when they are exposed to water flows provides the necessary knowledge to understand and manage the associated hazard for them. In this research, several experiments with humans were carried out in order to determine the stability limits to pedestrians crossing through a water flow in a real scale platform. The results obtained and by comparing those with human stability criteria proposed by other authors and guidelines provide a more restrictive criterion.

  12. Meeting the Demand for College Student Concerns in College Counseling Centers: Evaluating a Clinical Triage System (United States)

    Hardy, Jennifer A.; Weatherford, Ryan D.; Locke, Benjamin D.; DePalma, Natalie Hernandez; D'Iuso, Nadia T.


    University counseling centers, experiencing an imbalance between student demand and available resources, respond in various ways. The current mixed-method study evaluated one university counseling center transitioning from a wait-list system to a triage method of managing demand. Significant reductions in wait time and increase in attendance were…

  13. Development of motor coordination and cerebellar structure in male and female rat neonates exposed to hypergravity (United States)

    Nguon, K.; Ladd, B.; Baxter, M. G.; Sajdel-Sulkowska, E. M.


    We previously reported that the developing rat cerebellum is affected by exposure to hypergravity. In the present study, we explored the hypothesis that the changes in cerebellar structure in hypergravity-exposed rat neonates may affect their motor coordination. Furthermore, we hypothesized that the changes observed at 1.5G will be magnified at higher gravitational loading. To test this hypothesis, we compared motor behavior, cerebellar structure, and protein expression in rat neonates exposed to 1.5 1.75G on a 24-ft centrifuge daily for 22.5 h starting on gestational day (G) 10, through birth on G22/G23 and through postnatal day (P) 21. Exposure to hypergravity impacted the neurodevelopmental process as indicated by: (1) impaired righting response on P3, more than doubling the righting time at 1.75G, and (2) delayed onset of the startle response by one day, from P9 in controls to P10 in hypergravity-exposed pups. Hypergravity exposure resulted in impaired motor functions as evidenced by performance on a rotarod on P21; the duration of the stay on the rotarod recorded for 1.75G pups of both sexes was one tenth that of the stationary control (SC) pups. These changes in motor behavior were associated with cerebellar changes: (1) cerebellar mass on P6 was decreased by 7.5% in 1.5G-exposed male pups, 27.5% in 1.75G-exposed male pups, 17.5% in 1.5G-exposed female pups, and 22.5% in 1.75G female pups and (2) changes in the expression of glial and neuronal proteins. The results of this study suggest that perinatal exposure to hypergravity affects cerebellar development as evidenced by decreased cerebellar mass and altered cerebellar protein expression; cerebellar changes observed in hypergravity-exposed rat neonates are associated with impaired motor behavior. Furthermore, the response to hypergravity appears to be different in male and female neonates. If one accepts that the hypergravity paradigm is a useful animal model with which to predict those biological processes

  14. Geriatric Respondents and Non-Respondents To Probiotic Intervention Can Be Differentiated By Inherent Gut Microbiome Composition

    Directory of Open Access Journals (Sweden)

    Suja eSenan


    Full Text Available Scope: Probiotic interventions are known to have been shown to influence the composition of the intestinal microbiota in geriatrics. The growing concern is the apparent variation in response to identical strain dosage among human volunteers. One factor that governs this variation is the host gut microbiome. In this study, we attempted to define a core gut metagenome which could act as a predisposition signature marker of inherent bacterial community that can help predict the success of a probiotic intervention. Methods and Results: To characterize the geriatric gut microbiome we designed primers targeting the 16S rRNA hypervariable region V2-V3 followed by semiconductor sequencing using Ion Torrent PGM. Among respondents and non- respondents the chief genera of phylum Firmicutes that showed significant differences are Lactobacillus, Clostridium, Eubacterium, and Blautia (q< 0.002 while in the genera of phylum Proteobacteria included Shigella, Escherichia, Burkholderia and Camphylobacter (q <0.002. Conclusion: We have identified potential microbial biomarkers and taxonomic patterns that correlate with a positive response to probiotic intervention in geriatric volunteers. Future work with larger cohorts of geriatrics with diverse dietary influences could reveal the potential of the signature patterns of microbiota for personalized nutrition.

  15. Characterization of genes and pathways that respond to heat stress in Holstein calves through transcriptome analysis. (United States)

    Srikanth, Krishnamoorthy; Kwon, Anam; Lee, Eunjin; Chung, Hoyoung


    This study aimed to investigate the genes and pathways that respond to heat stress in Holstein bull calves exposed to severe ranges of temperature and humidity. A total of ten animals from 4 to 6 months of age were subjected to heat stress at 37 °C and 90 % humidity for 12 h. Skin and rectal temperatures were measured before and after heat stress; while no correlation was found between them before heat stress, a moderate correlation was detected after heat stress, confirming rectal temperature to be a better barometer for monitoring heat stress. RNAseq analysis identified 8567 genes to be differentially regulated, out of which 465 genes were significantly upregulated (≥2-fold, P heat stress. Significant terms and pathways enriched in response to heat stress included chaperones, cochaperones, cellular response to heat stress, phosphorylation, kinase activation, immune response, apoptosis, Toll-like receptor signaling pathway, Pi3K/AKT activation, protein processing in endoplasmic reticulum, interferon signaling, pathways in cancer, estrogen signaling pathway, and MAPK signaling pathway. The differentially expressed genes were validated by quantitative real-time PCR analysis, which confirmed the tendency of the expression. The genes and pathways identified in this analysis extend our understanding of transcriptional response to heat stress and their likely functioning in adapting the animal to hyperthermic stress. The identified genes could be used as candidate genes for association studies to select and breed animals with improved heat tolerance.

  16. A proteomic analysis of rice seedlings responding to 1,2,4-trichlorobenzene stress

    Institute of Scientific and Technical Information of China (English)

    GE Cailin; WAN Dingzhen; WANG Zegang; DING Yan; WANG Yulong; SHANG Qi; MA Fai; LUO Shishi


    The proteomic analysis of rice (Oryza sativa L.) roots and leaves responding tol,2,4-trichlorobenzene (TCB) stress was carried out by two dimensional gel electrophoresis,mass spectrometric (MS),and protein database analysis.The results showed that 5 mg/L TCB stress had a significant effect on global proteome in rice roots and leaves.The analysis of the category and function of TCB stress inducible proteins showed that different kinds of responses were produced in rice roots and leaves,when rice seedlings were exposed to 5 mg/L TCB stress.Most responses are essential for rice defending the damage of TCB stress.These responses include detoxication of toxic substances,expression of pathogenesis-related proteins,synthesis of cell wall substances and secondary compounds,regulation of protein and amino acid metabofism,activation of methiouine salvage pathway,and also include osmotic regulation and phytohormone metabolism.Comparing the TCB stress inducible proteins between the two cultivars,the β-glucosidasc and pathogenesis-related protein family 10 proteins were particularly induced by TCB stress in the roots of rice cultivar (Oryza sativa L.) Aizalzhan.and the glutathione S-transferase and aci-reductoue dioxygenase 4 were induced in the roots of rice cultivar Shanyou 63.This may be one of the important mechanisms for Shanyou 63 having higher tolerance to TCB stress than Aizaizhan.

  17. Differential rearing conditions and alcohol-preferring rats: consumption of and operant responding for ethanol. (United States)

    Deehan, Gerald A; Palmatier, Matthew I; Cain, Mary E; Kiefer, Stephen W


    Exposing rats to differential rearing conditions during early postweaning development has been shown to produce changes in a number of behaviors displayed during adulthood. The purpose of the present studies was to investigate whether rearing alcohol-preferring (P) and nonpreferring (NP) rats in an environmental enrichment condition (EC), a social condition (SC), or an impoverished condition (IC) would differentially affect self-administration of 10% ethanol. In Experiment 1, rats were tested for consumption of 10% ethanol in limited- and free-access tests. For Experiment 2, rats were trained to respond in an operant chamber for ethanol and then provided concurrent access to 10% ethanol and water. Each solution was presented in a separate liquid dipper after meeting the schedule of reinforcement on distinct levers. After concurrent access tests, the water lever/dipper was inactivated and a progressive ratio (PR) schedule was initiated. Three successive solutions (10% ethanol, 15% ethanol, and 10% sucrose) were tested under the PR. For P rats, rearing in an EC reduced ethanol consumption, preference, and motivation to obtain ethanol, relative to P rats reared in an IC. Thus, exposure to a novel environment immediately after weaning acted to decrease the reinforcing properties of ethanol in an animal model for alcoholism.

  18. Energy efficient data centers

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman


    Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

  19. Data from Interviews with 95 Respondents Recollecting Repeated Dental Visits

    Directory of Open Access Journals (Sweden)

    Rebecca M. Willén


    Full Text Available In 2012, Swedish dental care patients (n = 95 participated in a quasi-experiment in which they were interviewed twice about dental visits they had made between 2002 and 2012. For verification purposes, the participants' narratives were compared to the dental records. The qualitative data was quantified, stored as a .csv file, and supplemented with a codebook in plain text. All study materials are freely available online. The data can be reused to further analyse memory for repeated events. The data can be used both as data from an experiment (including both interviews and as single interview data (including data only from the first interview, i.e., before the respondents were provided with memory cues.

  20. Harmless error analysis: How do judges respond to confession errors? (United States)

    Wallace, D Brian; Kassin, Saul M


    In Arizona v. Fulminante (1991), the U.S. Supreme Court opened the door for appellate judges to conduct a harmless error analysis of erroneously admitted, coerced confessions. In this study, 132 judges from three states read a murder case summary, evaluated the defendant's guilt, assessed the voluntariness of his confession, and responded to implicit and explicit measures of harmless error. Results indicated that judges found a high-pressure confession to be coerced and hence improperly admitted into evidence. As in studies with mock jurors, however, the improper confession significantly increased their conviction rate in the absence of other evidence. On the harmless error measures, judges successfully overruled the confession when required to do so, indicating that they are capable of this analysis.

  1. Responding to non-linear internationalisation of public policy

    DEFF Research Database (Denmark)

    Daugbjerg, Carsten


    The transfer of regulatory authority to international organisations can initiate domestic policy reform. The internationalisation process can be a one-off transfer of authority to international institutions or an ongoing process. In the latter situation, the level of internationalisation may...... be gradually increased by expanding the regulatory scope of the regime or by deepening it. However, internationalisation processes may also involve stalemate or even reversal. How do domestic policy makers respond to such non-linear internationalisation? To answer this question, this paper analyzes...... the relationship between developments in the GATT and WTO farm trade negotiations and the reform trajectory of the EU's Common Agricultural Policy (CAP) from the early 1990s to 2013. Until 2008, the EU gradually changed the support instruments of the CAP to limit their trade distorting impact. After the Doha Round...

  2. Misery loves company: mood-congruent emotional responding to music. (United States)

    Hunter, Patrick G; Schellenberg, E Glenn; Griffith, Andrew T


    We examined emotional responding to music after mood induction. On each trial, listeners heard a 30-s music excerpt and rated how much they liked it, whether it sounded happy or sad, and how familiar it was. When the excerpts sounded unambiguously happy or sad (Experiment 1), the typical preference for happy-sounding music was eliminated after inducing a sad mood. When the excerpts sounded ambiguous with respect to happiness and sadness (Experiment 2), listeners perceived more sadness after inducing a sad mood. Sad moods had no influence on familiarity ratings (Experiments 1 and 2). These findings imply that "misery loves company." Listeners in a sad mood fail to show the typical preference for happy-sounding music, and they perceive more sadness in music that is ambiguous with respect to mood.

  3. Functional Hallucinations in Schizophrenia Responding to Adjunctive Sodium Valproate

    Directory of Open Access Journals (Sweden)

    Ravi Philip Rajkumar


    Full Text Available Functional hallucinations are a rare phenomenon, wherein hallucinations are triggered by a stimulus in the same modality, and co-occur with it. Although hallucinations in schizophrenia are normally treated using antipsychotics, not all patients respond to them. The following is the report of a patient with paranoid schizophrenia who experienced persistent functional hallucinations, triggered by the sound of machines in his factory, in the absence of other psychotic symptoms. These occurred despite adequate doses of risperidone, which had controlled his other symptoms. The addition of sodium valproate, titrated up to 1700 mg/day based on response and tolerability, resulted in a marked improvement in this phenomenon and enabled him to return to work. The implications and possible mechanisms of the patient′s response are discussed.

  4. Radar detection of drones responding to honeybee queen pheromone. (United States)

    Loper, G M; Wolf, W W; Taylor, O R


    The response of honey bee (Apis mellifera L.) drones to queen pheromone(s) (either natural from a mated queen, or synthetic from a lure) was recorded using an X-band, ground-based radar. The distribution of drones (insect targets on the radar screen) changed from a scattered distribution to a line concentration (downwind) when the pheromone was released. Displacement within the line concentration was toward the pheromone. This response was seen as far as 800±15 m downwind from a lure with 10 mg of synthetic 9-oxodec-trans-2-enoic acid (9-ODA) and as far as 420±15 m from a mated queen. These studies demonstrate that queen pheromone can be detected by drones at much greater distances than previously believed and illustrate how X-band radar may be used to establish the distances at which insects of similar or larger size respond to pheromones.

  5. Responding to the global economic crisis: inclusive social work practice. (United States)

    Strier, Ron


    The present global economic crisis raises new concerns for social workers. One of its most visible results is the further socioeconomic decline and marginalization of excluded populations. This article suggests that the current circumstances require a much more engaged, egalitarian, and reflexive practice-a practice, based on social rights, that matches the magnitude of the crisis and its negative impact on traditional social work constituencies. Consequently, the article suggests the concept of inclusive social work practice (ISWP), a conceptual framework whose main principles respond to four processes of social exclusion closely related to the present global crisis: extreme social isolation, growing dependency, multiple deprivation, and internalized oppression. The author describes the impact of the global crisis on patterns of social exclusion and presents the methodological foundations of the ISWP framework.

  6. Groupthink: How Should Clinicians Respond to Human Trafficking? (United States)

    Cheshire, William Polk


    Human trafficking is a pervasive problem that exceeds the capacity of social and organizational resources to restrain and for which guidelines are inadequate to assist medical professionals in responding to the special needs of victims when they present as patients. One obstacle to appropriate disagreement with an inadequate status quo is the lure of group cohesion. "Groupthink" is a social psychological phenomenon in which presumed group consensus prevails despite potentially adverse consequences. In the context of the medical response to human trafficking, groupthink may foster complacency, rationalize acquiescence with inaction on the basis of perceived futility, create an illusion of unanimity, and accommodate negative stereotyping. Despite these inhibiting influences, even in apparently futile situations, medical professionals have unique opportunities to be a force for good.

  7. Pioneering of Schools with International Standard to Respond the Globalization

    Directory of Open Access Journals (Sweden)

    Ipnugraha Ipnugraha


    Full Text Available In order to meet respond the challenges of globalization Indonesia Government held a Pioneering of Schools with International Standard (RSBI. As an international standard schools pilot, these schools prepared gradually through the guidance by government and stakeholders. Within a certain period of four years it is expected that the schools is able to fulfill and meet the criteria of Schools with International Standard (SBI. Actually, in it’s implementation, RSBI faces many challenges, among others, were expensive anda require modern infrastructure, require a qualified teacher, SBI criteria and English implementation in education not yet possessed constitutional base. With RSBI it will form a national school with national education standards that have international quality and its graduates are able to compete internationally

  8. Novel nano-composite biomaterials that respond to light. (United States)

    Hribar, Kolin C; Metter, Robert B; Burdick, Jason A


    Composites of nanoparticles and polymers are finding wide applications to alter material properties, conductivity, and utility. Here, we show that nano-composites can be designed to heat in the presence of near infrared light. This process is useful in transitioning materials through a transition temperature for a range of applications. For example, shape-memory materials (including polymers, metals, and ceramics) are those that are processed into a temporary shape and respond to some external stimuli (e.g., temperature) to undergo a transition back to a permanent shape and may be useful in a range of applications from aerospace to fabrics, to biomedical devices and microsystem components. In this work, we formulated composites of gold nanorods (<1% by volume) and biodegradable networks, where exposure to infrared light induced heating and consequently, shape transitions. The heating is repeatable and tunable based on nanorod concentration and light intensity.

  9. Respondents, Operants, and Emergents: Toward an Integrated Perspective on Behavior (United States)

    Rumbaugh, Daune M.; Washburn, David A.; Hillix, William A.


    A triarchic organization of behavior, building on Skinner's description of respondents and operants, is proposed by introducing a third class of behavior called 'emergents.' Emergents are new responses, never specifically reinforced, that require operations more complex than association. Some of these operations occur naturally only in animals above a minimum level of brain complexity, and are developed in an interaction between treatment and organismic variables. (Here complexity is defined in terms of relative levels of hierarchical integration made possible both by the amount of brain, afforded both by brain-body allometric relationships and by encephalization, and, also, the elaboration of dendritic and synaptic connections within the cortex and connections between various parts/regions of the brain.) Examples of emergents are discussed to advance this triarchic view, of behavior. The prime example is language. This triarchic view reflects both the common goals and the cumulative nature of psychological science.

  10. Capacity of Old Trees to Respond to Environmental Change

    Institute of Scientific and Technical Information of China (English)

    Nathan G. Phillips; Thomas N.Buckley; David T.Tissue


    Atmospheric carbon dioxide [CO2] has increased dramatically within the current life spans of long-lived trees and old forests. Consider that a 500-year-old tree in the early twenty-first century has spent 70% of its life growing under preIndustrial levels of [CO2], which were 30% lower than current levels. Here we address the question of whether old trees have already responded to the rapid rise in [CO2] occurring over the past 150 years. In spite of limited data, aging trees have been shown to possess a substantial capacity for increased net growth after a period of post-maturity growth decline.Observations of renewed growth and physiological function in old trees have, in some instances, coincided with Industrial Age increases in key environmental resources, including [CO2], suggesting the potential for continued growth in old trees as a function of continued global climate change.

  11. Functional hallucinations in schizophrenia responding to adjunctive sodium valproate. (United States)

    Rajkumar, Ravi Philip


    Functional hallucinations are a rare phenomenon, wherein hallucinations are triggered by a stimulus in the same modality, and co-occur with it. Although hallucinations in schizophrenia are normally treated using antipsychotics, not all patients respond to them. The following is the report of a patient with paranoid schizophrenia who experienced persistent functional hallucinations, triggered by the sound of machines in his factory, in the absence of other psychotic symptoms. These occurred despite adequate doses of risperidone, which had controlled his other symptoms. The addition of sodium valproate, titrated up to 1700 mg/day based on response and tolerability, resulted in a marked improvement in this phenomenon and enabled him to return to work. The implications and possible mechanisms of the patient's response are discussed.

  12. [The epidemiological profile of subjects exposed to rabies in Abidjan, Ivory Coast]. (United States)

    Tiembré, Issaka; Vroh Benié Bi, Joseph; N'Cho Dagnan, Simplice; Kouadio Ekra, Daniel; Zebe, Sonia; Tagliante-Saracino, Janine


    The purpose of this study is to describe the epidemiological profile of subjects exposed to rabies in the anti-rabies center of Abidjan in Ivory Coast. The paper is based on a cross-sectional study conducted among all people exposed to the risk of rabies and followed in the anti-rabies center from January to December 2008. During the study period, 2,673 subjects were exposed, i.e. 5 exposures for every 10,000 persons. 1,534 patients (57.4%) were male. The most exposed age groups were the 0-9 and 10-19 age groups (22.4% and 29.5% respectively). In Abidjan, 608 individuals (22.7%) were exposed in Cocody, 471 individuals (17.6%) in Abobo, and 310 individuals (11.6%) in Yopougon. Exposure occurred in 76.9% of cases (2,055 subjects) at home and exclusively concerned visitors of the family. Exposures by animal bites represented 88.1% (2,354 subjects) of all cases, while 23.2% (620 subjects) of exposures were category III. The average period between exposure and consultation was 10 days. Subjects were exposed as a result of contact with a dog in 92.1 % of cases (2,462 subjects). The animal was found alive in 74.9% (2,002 cases) and was not immunized in 87.2% of cases (2,331). Post-exposure prophylaxis was given up by 1,470 persons (55.2%). 13 subjects were received at the stage of clinical rabies. Increased knowledge of the epidemiological profile of rabies exposure will contribute to improving the management of the disease in Ivory Coast.

  13. Primate dental ecology: How teeth respond to the environment. (United States)

    Cuozzo, Frank P; Ungar, Peter S; Sauther, Michelle L


    Teeth are central for the study of ecology, as teeth are at the direct interface between an organism and its environment. Recent years have witnessed a rapid growth in the use of teeth to understand a broad range of topics in living and fossil primate biology. This in part reflects new techniques for assessing ways in which teeth respond to, and interact with, an organism's environment. Long-term studies of wild primate populations that integrate dental analyses have also provided a new context for understanding primate interactions with their environments. These new techniques and long-term field studies have allowed the development of a new perspective-dental ecology. We define dental ecology as the broad study of how teeth respond to, or interact with, the environment. This includes identifying patterns of dental pathology and tooth use-wear, as they reflect feeding ecology, behavior, and habitat variation, including areas impacted by anthropogenic disturbance, and how dental development can reflect environmental change and/or stress. The dental ecology approach, built on collaboration between dental experts and ecologists, holds the potential to provide an important theoretical and practical framework for inferring ecology and behavior of fossil forms, for assessing environmental change in living populations, and for understanding ways in which habitat impacts primate growth and development. This symposium issue brings together experts on dental morphology, growth and development, tooth wear and health, primate ecology, and paleontology, to explore the broad application of dental ecology to questions of how living and fossil primates interact with their environments.

  14. A tracking technology for security personnel and first responders (United States)

    Womble, Phillip; Barzilov, Alexander; Paschal, Jon; Hopper, Lindsay; Music, Abe; Morgan, Timothy; Moore, Ryan; Pinson, Dudley; Schultz, Frederick; Maston, Michael J.; Kowalik, Robert


    Northwest Nuclear, LLC (NWN), the Applied Physics Institute (API) at Western Kentucky University, and Crisis Prep Services, LLC (CPS) have developed a tracking technology for first responders and security personnel based upon the AeroScout system (a product of AeroScout, Inc.) and technologies developed independently by NWN, API, and CPS. These systems provide location information using 802.11XXX architecture by measuring the time of arrival of packets from a set of active radio frequency (RF) tags to a set of location receivers. The system can track and graphically display the location on maps, drawings, floor plans or photographs of tagged items on any 802.11-compliant devices (PDAs, laptops, computers, WiFi telephones) situated both outside and inside structures. This location information would be vital for tracking the location of first responders, security, and other emergency personnel during rescue operations; particularly, under adverse conditions (e.g., fires). NWN, API, and CPS have been improving the precision of the location measurement to an uncertainty of 20 cm or 8 inches (under certain conditions) and also developing algorithms to increase the accuracy. NWN and API personnel have developed: 1) special tags which indicate tampering or sudden movement and transmit briefly under these conditions, and 2) permanent and portable systems which can be deployed rapidly. Additional software created by Crisis Prep Services, LLC allows response force personnel to be tracked and located inside a building in real time as well as use the software and tags as a training and rehersal system. The location of each person is depicted on a drawing of the building and is displayed on a laptop computer or any other browser capable device.

  15. Cortisol concentrations in follicular fluid of 'low responder' patients. (United States)

    Bider, D; Shine, S; Tur-Kaspa, I; Levron, J; Dor, J


    The study was undertaken to examine any differences existing in total cortisol concentrations in the follicular fluid (FF) of pre-ruptured follicles between 'low responder' patients (group 1, n = 20) and 'good responder' patients (group 2, n = 15). The groups were defined according to how many oocytes had been retrieved during the previous in-vitro fertilization procedure (group 1: three or fewer; group 2: more than three) and total oestradiol concentration at previous in-vitro fertilization (IVF) (group 1: 500 pg/ml). All patients were aged 36-43 years (group 1 mean +/- SD: 38.2 +/- 4.7; group 2: 32.1 +/- 3.8 years) and were diagnosed with tubal or unexplained infertility. The total FF cortisol concentrations obtained in conjunction with an IVF procedure were assayed and related to oocyte fertilization. Follicular fluid was analysed for total cortisol content. Only follicles between 19 and 20 mm diameter were analysed in both groups. After aspiration of blood-free FF, total cortisol concentrations were measured by radioimmunoassay, designed for the quantitative measurement of cortisol, and related to oocyte fertilization. Total cortisol concentration in FF from fertilized oocytes was 9.7 +/- 0.6 microg/ml (mean +/- SD) in group 1 compared to 9.2 +/- 4.4 microg/ml in group 2 (not statistically significant). Total cortisol concentrations were not associated with oocyte fertilization and no difference between the groups was found in total cortisol concentrations in the FF of unfertilized oocytes or empty follicles.

  16. Electroencephalographic brain dynamics following manually responded visual targets.

    Directory of Open Access Journals (Sweden)

    Scott Makeig


    Full Text Available Scalp-recorded electroencephalographic (EEG signals produced by partial synchronization of cortical field activity mix locally synchronous electrical activities of many cortical areas. Analysis of event-related EEG signals typically assumes that poststimulus potentials emerge out of a flat baseline. Signals associated with a particular type of cognitive event are then assessed by averaging data from each scalp channel across trials, producing averaged event-related potentials (ERPs. ERP averaging, however, filters out much of the information about cortical dynamics available in the unaveraged data trials. Here, we studied the dynamics of cortical electrical activity while subjects detected and manually responded to visual targets, viewing signals retained in ERP averages not as responses of an otherwise silent system but as resulting from event-related alterations in ongoing EEG processes. We applied infomax independent component analysis to parse the dynamics of the unaveraged 31-channel EEG signals into maximally independent processes, then clustered the resulting processes across subjects by similarities in their scalp maps and activity power spectra, identifying nine classes of EEG processes with distinct spatial distributions and event-related dynamics. Coupled two-cycle postmotor theta bursts followed button presses in frontal midline and somatomotor clusters, while the broad postmotor "P300" positivity summed distinct contributions from several classes of frontal, parietal, and occipital processes. The observed event-related changes in local field activities, within and between cortical areas, may serve to modulate the strength of spike-based communication between cortical areas to update attention, expectancy, memory, and motor preparation during and after target recognition and speeded responding.

  17. Management of Crohn's disease in poor responders to adalimumab

    Directory of Open Access Journals (Sweden)

    de Boer NKH


    Full Text Available Nanne KH de Boer,1 Mark Löwenberg,2 Frank Hoentjen3 1Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, the Netherlands; 2Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands; 3Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands Abstract: Anti-tumor necrosis factor therapy with adalimumab is an effective therapy for the induction and maintenance of remission in moderate to severe Crohn's disease. Although a large proportion of patients show a favorable clinical response to adalimumab, therapy failure is common. In this review, we provide a practical overview of adalimumab therapy in patients with Crohn's disease, with a specific focus on the clinical management of adalimumab failure. In the case of inadequate efficacy, a thorough assessment is required to confirm inflammatory disease activity and rule out noninflammatory causes. Evaluation may include biomarkers (fecal calprotectin and serum C-reactive protein, colonoscopy, and/or magnetic resonance enterography/enteroclysis. Furthermore, adalimumab trough levels and antibodies to adalimumab are informational after the confirmation of active inflammation. In the case of low or undetectable adalimumab trough levels, dose escalation to 40 mg weekly is recommended, whereas high antibody titers or adverse events frequently require switching to an alternative anti-TNF agent such as infliximab. Active inflammation despite therapeutic adalimumab trough levels requires alternative strategies such as switching to drugs with a different mode of action or surgical intervention. Keywords: anti-TNF, biological, inflammatory bowel disease, loss of response, infliximab

  18. The National Climate Change and Wildlife Science Center annual report for 2013 (United States)

    Varela-Acevedo, Elda


    In 2008, Congress created the National Climate Change and Wildlife Science Center (NCCWSC) within the U.S. Geological Survey (USGS). The center was formed to respond to the demands of natural resource managers for rigorous scientific information and effective tools for assessing and responding to climate change. Located at the USGS National Headquarters in Reston, Va., the NCCWSC has invested more than $93 million (through FY13) in cutting-edge climate change research and, in response to Secretarial Order No. 3289, established and is managing eight regional Department of Interior (DOI) Climate Science Centers (CSCs). In 2013:

  19. Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats. (United States)

    Beaudin, Stéphane A; Stangle, Diane E; Smith, Donald R; Levitsky, David A; Strupp, Barbara J


    This study evaluated the efficacy of a 3-week course of succimer treatment to alleviate behavioral deficits in rats exposed to lead (Pb) for the first 4 weeks of life. A 3 x 2 factorial design was used: three levels of lead exposure (No Pb, Moderate, and High Pb) and two levels of chelation (succimer or vehicle). Behavioral testing was conducted following chelation therapy, from 2 to 9 months of age; this report presents the results of two of the administered tasks: (1) a conditional olfactory discrimination task (baseline task), and (2) a conditional olfactory discrimination task with periodic reward omission on some correct trials (RO task). In the RO task, the performance disruption produced by committing an error on the previous trial was significantly greater for both unchelated lead-exposed groups than for controls. The High Pb rats were also more sensitive to reward omission than controls, providing converging evidence for impaired regulation of arousal or emotion. Importantly, succimer treatment was effective in normalizing the heightened reactivity of the lead-exposed animals to both errors and reward omission. In addition, non-lead-exposed rats that were treated with succimer tended to be more affected by a prior error than controls in their latency to respond on post-error trials. In sum, these findings provide new evidence that succimer chelation can significantly lessen the lasting neurobehavioral dysfunction produced by early lead exposure, but also suggest that there may be risks of administering the drug to individuals without elevated blood lead levels.

  20. “Complexities of holistic community based participatory research for a low-income, multi-ethnic population exposed to multiple built-environment stressors in Worcester, Massachusetts” (United States)

    Downs, Timothy J.; Ross, Laurie; Patton, Suzanne; Rulnick, Sarah; Sinha, Deb; Mucciarone, Danielle; Calvache, Maria; Parmenter, Sarah; Subedi, Rajendra; Wysokenski, Donna; Anderson, Erin; Dezan, Rebecca; Lowe, Kate; Bowen, Jennifer; Tejani, Amee; Piersanti, Kelly; Taylor, Octavia; Goble, Robert


    Low income, multi-ethnic communities in Main South/Piedmont neighborhoods of Worcester, Massachusetts are exposed to cumulative, chronic built-environment stressors, and have limited capacity to respond, magnifying their vulnerability to adverse health outcomes. “Neighborhood STRENGTH”, our community based participatory research (CBPR) project, comprised four partners: a youth center; an environmental non-profit; a community based health center; and a university. Unlike most CBPR projects that are single topic-focused, our ‘holistic’, systems-based project targeted five priorities. The three research-focused/action-oriented components were: 1) participatory monitoring of indoor and outdoor pollution; 2) learning about health needs and concerns of residents through community based listening sessions; and 3) engaging in collaborative survey work, including a household vulnerability survey and an asthma prevalence survey for schoolchildren. The two action-focused/research-informed components were: 4) tackling persistent street trash and illegal dumping strategically; and 5) educating and empowering youth to promote environmental justice. We used a coupled CBPR-capacity building approach to design, vulnerability theory to frame, and mixed methods: quantitative environmental testing and qualitative surveys. Process and outcomes yielded important lessons: vulnerability theory helps frame issues holistically; having several topic-based projects yielded useful information, but was hard to manage and articulate to the public; access to, and engagement with, the target population was very difficult and would have benefited greatly from having representative residents who were paid at the partners' table. Engagement with residents and conflict burden varied highly across components. Notwithstanding, we built enabling capacity, strengthened our understanding of vulnerability, and are able to share valuable experiential knowledge. PMID:19762014

  1. Complexities of holistic community-based participatory research for a low income, multi-ethnic population exposed to multiple built-environment stressors in Worcester, Massachusetts. (United States)

    Downs, Timothy J; Ross, Laurie; Patton, Suzanne; Rulnick, Sarah; Sinha, Deb; Mucciarone, Danielle; Calvache, Maria; Parmenter, Sarah; Subedi, Rajendra; Wysokenski, Donna; Anderson, Erin; Dezan, Rebecca; Lowe, Kate; Bowen, Jennifer; Tejani, Amee; Piersanti, Kelly; Taylor, Octavia; Goble, Robert


    Low income, multi-ethnic communities in Main South/Piedmont neighborhoods of Worcester, Massachusetts are exposed to cumulative, chronic built-environment stressors, and have limited capacity to respond, magnifying their vulnerability to adverse health outcomes. "Neighborhood STRENGTH", our community-based participatory research (CBPR) project, comprised four partners: a youth center; an environmental non-profit; a community-based health center; and a university. Unlike most CBPR projects that are single topic-focused, our 'holistic', systems-based project targeted five priorities. The three research-focused/action-oriented components were: (1) participatory monitoring of indoor and outdoor pollution; (2) learning about health needs and concerns of residents through community-based listening sessions; (3) engaging in collaborative survey work, including a household vulnerability survey and an asthma prevalence survey for schoolchildren. The two action-focused/research-informed components were: (4) tackling persistent street trash and illegal dumping strategically; and (5) educating and empowering youth to promote environmental justice. We used a coupled CBPR-capacity building approach to design, vulnerability theory to frame, and mixed methods: quantitative environmental testing and qualitative surveys. Process and outcomes yielded important lessons: vulnerability theory helps frame issues holistically; having several topic-based projects yielded useful information, but was hard to manage and articulate to the public; access to, and engagement with, the target population was very difficult and would have benefited greatly from having representative residents who were paid at the partners' table. Engagement with residents and conflict burden varied highly across components. Notwithstanding, we built enabling capacity, strengthened our understanding of vulnerability, and are able to share valuable experiential knowledge.

  2. National Automotive Center - NAC (United States)

    Federal Laboratory Consortium — Encouraged by the advantages of collaboration, the U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) worked with the Secretary of the...

  3. Test Control Center (United States)


    At the test observation periscope in the Test Control Center exhibit in StenniSphere at the John C. Stennis Space Center in Hancock County, Miss., visitors can observe a test of a Space Shuttle Main Engine exactly as test engineers might see it during a real engine test. The Test Control Center exhibit exactly simulates not only the test control environment, but also the procedure of testing a rocket engine. Designed to entertain while educating, StenniSphere includes informative dispays and exhibits from NASA's lead center for rocket propulsion and remote sensing applications. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  4. Cooperative Tagging Center (CTC) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cooperative Tagging Center (CTC) began as the Cooperative Game Fish Tagging Program (GTP) at Woods Hole Oceanographic Institute (WHOI) in 1954. The GTP was...

  5. NMA Analysis Center (United States)

    Kierulf, Halfdan Pascal; Andersen, Per Helge


    The Norwegian Mapping Authority (NMA) has during the last few years had a close cooperation with Norwegian Defence Research Establishment (FFI) in the analysis of space geodetic data using the GEOSAT software. In 2012 NMA has taken over the full responsibility for the GEOSAT software. This implies that FFI stopped being an IVS Associate Analysis Center in 2012. NMA has been an IVS Associate Analysis Center since 28 October 2010. NMA's contributions to the IVS as an Analysis Centers focus primarily on routine production of session-by-session unconstrained and consistent normal equations by GEOSAT as input to the IVS combined solution. After the recent improvements, we expect that VLBI results produced with GEOSAT will be consistent with results from the other VLBI Analysis Centers to a satisfactory level.

  6. Center for Contaminated Sediments (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers Center for Contaminated Sediments serves as a clearinghouse for technology and expertise concerned with contaminated sediments. The...

  7. Reliability Centered Maintenance - Methodologies (United States)

    Kammerer, Catherine C.


    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  8. The ORFEUS Data Center

    Directory of Open Access Journals (Sweden)

    B. Dost


    Full Text Available 1993 the ORFEUS Data Center (ODC; Dost, 1991 changed hosting organisation. It moved within the Netherlands from the University of Utrecht to the Royal Netherlands Meteorological Institute (KNM1 in de Bilt. This change in hosting organisation was necessary to ensure a longer term stability in the operation of the ODC. Key issues for the ODC are the rapid on-line data access and quality controlled, complete and efficient off-line data access. During 1992 the ODC became the European node in the international SPYDER system which provides near real-time access to digital broadband data from selected high quality stations. Electronic messages trigger soveral centers well distributed over the globe. These centers then collect the data by modem from selected stations in their region. Finally, data are distributed between data centers over internet.

  9. Advanced data center economy


    Sukhov, R.; Amzarakov, M.; E. Isaev


    The article addresses basic Data Centers (DC) drivers of price and engineering, which specify rules and price evaluation for creation and further operation. DC energy efficiency concept, its influence on DC initial price, operation costs and Total Cost of Ownership.

  10. Center Innovation Fund Program (United States)

    National Aeronautics and Space Administration — To stimulate and encourage creativity and innovation within the NASA Centers. The activities are envisioned to fall within the scope of NASA Space Technology or...

  11. Global Hydrology Research Center (United States)

    National Aeronautics and Space Administration — The GHRC is the data management and user services arm of the Global Hydrology and Climate Center. It encompasses the data and information management, supporting...

  12. National Farm Medicine Center (United States)

    Research Areas Applied Sciences Biomedical Informatics Clinical Research Epidemiology Farm Medicine Human Genetics Oral-Systemic Health Clinical ... Consulting Agritourism Farm MAPPER Lyme Disease ROPS Rebate Zika Virus National Farm Medicine Center The National Farm ...

  13. Hazardous Waste Research Center (United States)

    Federal Laboratory Consortium — A full-service research and evaluation center equipped with safety equipment, a high-bay pilot studies area, and a large-scale pilot studies facility The U.S. Army...

  14. Carbon Monoxide Information Center

    Medline Plus

    Full Text Available ... Community Outreach Resource Center Toy Recall Statistics CO Poster Contest Pool Safely Business & Manufacturing Business & Manufacturing Business ... Featured Resources CPSC announces winners of carbon monoxide poster contest Video View the blog Clues You Can ...

  15. World Trade Center

    Index Scriptorium Estoniae


    Esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

  16. Health Center Controlled Network (United States)

    U.S. Department of Health & Human Services — The Health Center Controlled Network (HCCN) tool is a locator tool designed to make data and information concerning HCCN resources more easily available to our...

  17. USU Patient Simulation Center (United States)

    Federal Laboratory Consortium — he National Capital Area (NCA) Medical Simulation Center is a state-of-the-art training facility located near the main USU campus. It uses simulated patients (i.e.,...

  18. HUD Homeownership Centers (United States)

    Department of Housing and Urban Development — HUD Homeownership Centers (HOCs) insure single family Federal Housing Administration (FHA) mortgages and oversee the selling of HUD homes. FHA has four Homeownership...

  19. Mental Health Screening Center (United States)

    ... Releases & Announcements Public Service Announcements Partnering with DBSA Mental Health Screening Center These online screening tools are not ... you have any concerns, see your doctor or mental health professional. Depression This screening form was developed from ...

  20. FEMA Disaster Recovery Centers (United States)

    Department of Homeland Security — This is a search site for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  1. Centering in Japanese Discourse

    CERN Document Server

    Walker, M; Côté, S; Walker, Marilyn; Iida, Masayo; Cote, Sharon


    In this paper we propose a computational treatment of the resolution of zero pronouns in Japanese discourse, using an adaptation of the centering algorithm. We are able to factor language-specific dependencies into one parameter of the centering algorithm. Previous analyses have stipulated that a zero pronoun and its cospecifier must share a grammatical function property such as {\\sc Subject} or {\\sc NonSubject}. We show that this property-sharing stipulation is unneeded. In addition we propose the notion of {\\sc topic ambiguity} within the centering framework, which predicts some ambiguities that occur in Japanese discourse. This analysis has implications for the design of language-independent discourse modules for Natural Language systems. The centering algorithm has been implemented in an HPSG Natural Language system with both English and Japanese grammars.

  2. Accredited Birth Centers (United States)

    ... 9743 Accredited since January 2016 98 Bright Eyes Midwifery and Wild Rivers Women's Health Accredited 29135 Ellensburg ... Accredited since November 2015 96 Footprints in Time Midwifery Services and Birth Center Accredited 351 N. Water ...

  3. Advanced Missile Signature Center (United States)

    Federal Laboratory Consortium — The Advanced Missile Signature Center (AMSC) is a national facility supporting the Missile Defense Agency (MDA) and other DoD programs and customers with analysis,...

  4. Oil Reserve Center Established

    Institute of Scientific and Technical Information of China (English)


    Like other countries,China has started to grow its strategic oil reserve in case oil supplies are cut On December 18,2007,the National Development and Reform Commission(NDRC),China’s top economic planner,announced that the national oil reserve center has been officially launched.The supervisory system over the oil reserves has three levels: the energy department of the NDRC,the oil reserve center,and the reserve bases.

  5. Data center cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Chainer, Timothy J; Dang, Hien P; Parida, Pritish R; Schultz, Mark D; Sharma, Arun


    A data center cooling system may include heat transfer equipment to cool a liquid coolant without vapor compression refrigeration, and the liquid coolant is used on a liquid cooled information technology equipment rack housed in the data center. The system may also include a controller-apparatus to regulate the liquid coolant flow to the liquid cooled information technology equipment rack through a range of liquid coolant flow values based upon information technology equipment temperature thresholds.

  6. National Biocontainment Training Center (United States)


    than ever before as scientists push to understand the pathology and develop diagnostics, vaccines and therapeutics for deadly diseases like Ebola...Hardcastle, Vickie Jones, Sheri Leavitt, and Belinda Rivera. Gulf Coast Consortium Postdoctoral Veterinary Training Program - A clinical veterinarian from...the Center for Comparative Medicine at Baylor College of Medicine in Houston and a veterinarian from the University of Texas Health Science Center

  7. Uniform Protection for Multi-exposed Targets

    DEFF Research Database (Denmark)

    Vigo, Roberto; Nielson, Flemming; Nielson, Hanne Riis


    Ensuring that information is protected proportionately to its value is a major challenge in the development of robust distributed systems, where code complexity and technological constraints might allow reaching a key functionality along various paths. We propose a protection analysis over...... the Quality Calculus that computes the combinations of data required to reach a program point and relates them to a notion of cost. In this way, we can compare the security deployed on different paths that expose the same resource. The analysis is formalised in terms of flow logic, and is implemented...

  8. Cochlear condition and olivocochlear system of gas station attendants exposed to organic solvents

    Directory of Open Access Journals (Sweden)

    Tochetto, Tania Maria


    Full Text Available Introduction: Organic solvents have been increasingly studied due to its ototoxic action. Objective: Evaluate the conditions of outer hair cells and olivocochlear system in individuals exposed to organic solvents. Method: This is a prospective study. 78 gas station attendants exposed to organic solvents had been evaluated from three gas stations from Santa Maria city, Rio Grande do Sul (RS. After applying the inclusion criteria, the sample was constituted by 24 individuals. The procedures used on the evaluation were audiological anamnesis, Transient otoacoustic emissions (TEOAES and research for the suppressive effect of TEOAES. A group control (GC compounded by 23 individuals was compared to individuals exposed and non-exposed individuals. The data collection has been done in the room of Speech Therapy of Workers Health Reference Center of Santa Maria. Results: The TEOAES presence was major in the left ear in both groups; the average relation of TEOAES signal/noise in both ears was greater in GE; the TEOAES suppressive effect in the right ear was higher in the individual of GE (62,5% and in the left ear was superior in GC (86,96%, with statistically significant difference. The median sign/noise ratio of TEOAES, according to the frequency range, it was higher in GC in three frequencies ranges in the right ear and one in the left ear. Conclusion: It was not found signs of alteration on the outer hair cells neither on the olivocochlear medial system in the individuals exposed to organic solvents.

  9. Significant alterations in reported clinical practice associated with increased oversight of organ transplant center performance. (United States)

    Schold, Jesse D; Arrington, Charlotte J; Levine, Greg


    In the past several years, emphasis on quality metrics in the field of organ transplantation has increased significantly, largely because of the new conditions of participation issued by the Centers for Medicare and Medicaid Services. These regulations directly associate patients' outcomes and measured performance of centers with the distribution of public funding to institutions. Moreover, insurers and marketing ventures have used publicly available outcomes data from transplant centers for business decision making and advertisement purposes. We gave a 10-question survey to attendees of the Transplant Management Forum at the 2009 meeting of the United Network for Organ Sharing to ascertain how centers have responded to the increased oversight of performance. Of 63 responses, 55% indicated a low or near low performance rating at their center in the past 3 years. Respondents from low-performing centers were significantly more likely to indicate increased selection criteria for candidates (81% vs 38%, P = .001) and donors (77% vs 31%, P < .001) as well as alterations in clinical protocols (84% vs 52%, P = .007). Among respondents indicating lost insurance contracts (31%), these differences were also highly significant. Based on respondents' perceptions, outcomes of performance evaluations are associated with significant changes in clinical practice at transplant centers. The transplant community and policy makers should practice vigilance that performance evaluations and regulatory oversight do not inadvertently lead to diminished access to care among viable candidates or decreased transplant volume.

  10. Protection of man: the exposed individual

    Energy Technology Data Exchange (ETDEWEB)

    Bohnstedt, A.; Knebel, J.U. [Programme Nuclear Safety Research, Karlsruhe Institute of Technology, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Breustedt, B. [Institute for Radiation Research, Karlsruhe Institute of Technology, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)


    Present methods for quantifying radiation exposure rely on a standardized reference man (75 kg) with defined average anatomical and physiological data. But individual person actually exposed differs from this idealized standard man. Therefore the focus of investigations at the Institute for Radiation Research (Institut fuer Strahlenforschung, ISF) which was founded at Karlsruhe Institute of Technology (Karlsruher Institut fuer Technologie, KIT) in 2009 is based on the vision to place the exposed individual with its anatomical and physiological particularities, under consideration of age, gender, body height, body shape and environment, in the centre of an individual-related quantification of the external and internal radiation exposure. Research work at the ISF is aiming at quantifying radiation exposure by improved determination of doses essentially caused by external radiation fields and the intake of radionuclides into the body. The three main topics of the institute are - external dosimetry (e.g. using a (voxel) model of the hand to simulate skin dose distribution); - internal dosimetry (e.g. body size related efficiency calibration of in-vivo counting equipment); - numerical methods/modeling (e.g. development of a mathematical/voxel-hybrid model of the human body). (authors)

  11. Dynamic properties of ultraviolet-exposed polyurea (United States)

    Youssef, George; Whitten, Ian


    Polyurea is used in military and civilian applications, where exposure to the sun in long durations is imminent. Extended exposure to ultraviolet radiation from the sun can deteriorate its mechanical performance to suboptimal levels. This study reports on the dynamic mechanical properties of polyurea as a function of ultraviolet radiation exposure duration. Six sets of samples were continuously exposed to ultraviolet radiation for different durations up to 18 weeks. Control samples were also tested that did not receive ultraviolet exposure. The dynamic properties were measured using a dynamic mechanical analyzer. Exposed samples exhibited significant color changes from transparent yellow to opaque tan after 18 weeks of exposure. Changes of color were observed as early as 3 weeks of exposure. The dynamic properties showed an initial increase in the dynamic modulus after 3 weeks of exposure, with no further significant change in the stiffness thereafter. The ultraviolet exposure had a significant impact at relatively short loading times or low temperature, for example, up to 6 decades of time. As loading time increases or polyurea operates at high temperature, the effect of ultraviolet exposure and temperature on the performance become highly coupled.

  12. Cancer occurrence among workers exposed to acrylonitrile. (United States)

    Rothman, K J


    A MEDLINE search identified 12 published epidemiologic studies that have reported incidence or mortality experience among workers exposed to acrylonitrile. Many of the studies contain scanty descriptions of subject ascertainment, and most do not have good information on exposure assessment. Many also may have suffered from incomplete follow-up, as evinced by an overall deficit in the number of deaths observed, compared with the number expected from general population mortality rates. Such problems are not unique to studies on acrylonitrile, and to some extent they reflect the difficulties of conducting retrospective cohort studies. Despite these drawbacks, a simplified meta-analysis of the mortality experience reported for these cohorts revealed little evidence for carcinogenicity. Approximately the same number of cancer deaths was observed as was expected according to general population mortality rates (standardized mortality ratio 1.03, 90% confidence interval 0.92-1.15). The combined information from these studies is insufficient to support confidence about a lack of carcinogenicity at all sites. Nevertheless, despite the flaws in some of the individual studies, the summarized findings offer reassurance that workers exposed to acrylonitrile face no striking increases in mortality for all cancers or for respiratory cancer.

  13. Development of an IgG4-RD Responder Index

    Directory of Open Access Journals (Sweden)

    Mollie N. Carruthers


    Full Text Available IgG4-related disease (IgG4-RD is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are required to clarify the natural history, long-term prognosis, and treatment approaches in this recently recognized condition. Patients with IgG4-RD have different organ manifestations and are followed by multiple specialties. Divergent approaches to the assessment of patients can complicate the interpretation of studies, emphasizing the critical need for validated outcome measures, particularly assessments of disease activity and response to treatment. We developed a prototype IgG4-RD Responder Index (IgG4-RD RI based on the approach used in the development of the Birmingham Vasculitis Activity Score for Wegener’s granulomatosis (BVAS/WG. The IgG4-RD RI was refined by members of the International IgG4-RD Symposium Organizing Committee in a paper case exercise. The revised instrument was applied retrospectively to fifteen IgG4-RD patients at our institution. Those scores were compared to physician’s global assessment scale for the same visits. This paper describes the philosophy and goals of the IgG4-RD RI, the steps in the development of this instrument to date, and future plans for validation of this instrument as an outcome measure.

  14. Respondent-driven sampling and an unusual epidemic

    CERN Document Server

    Malmros, Jens; Britton, Tom


    Respondent-driven sampling (RDS) is frequently used when sampling hard-to-reach and/or stigmatized communities. RDS utilizes a peer-driven recruitment mechanism where sampled individuals pass on participation coupons to at most $c$ of their acquaintances in the community ($c=3$ being a common choice), who then in turn pass on to their acquaintances if they choose to participate, and so on. This process of distributing coupons is shown to behave like a new Reed-Frost type network epidemic model, in which becoming infected corresponds to receiving a coupon. The difference from existing network epidemic models is that an infected individual can not infect (i.e.\\ sample) all of its contacts, but only at most $c$ of them. We calculate $R_0$, the probability of a major "outbreak", and the relative size of a major outbreak in the limit of infinite population size and evaluate their adequacy in finite populations. We study the effect of varying $c$ and compare RDS to the corresponding usual epidemic models, i.e.\\ the...

  15. Responding to the Rise of China – attraction or compulsion?

    DEFF Research Database (Denmark)

    Overgaard, Signe

    In recent years there has been much talk about when the Chinese economy will overtake the U.S., and whether our education system will be able to keep up with China in the future. Although the Danish media continue to deliver critical reports on the human rights situation in China, our involvement...... not address the above questions. This research will therefore attempt to fill this gap by using qualitative interviews to understand the motivations behind the ways Danish people respond to the rise China.......In recent years there has been much talk about when the Chinese economy will overtake the U.S., and whether our education system will be able to keep up with China in the future. Although the Danish media continue to deliver critical reports on the human rights situation in China, our involvement...... with China has never been greater. This is not surprising, as China in recent years has put great efforts into cultivating its soft power . But this soft power is also full of contradictions, as the attitudes towards China span from fascination to contempt, depending on the topic on debate. And from...

  16. Alopecia mucinosa responding to antileprosy treatment: Are we missing something?

    Directory of Open Access Journals (Sweden)

    Rajiv Joshi


    Full Text Available Three cases with single lesion of Alopecia mucinosa (follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Two children, a boy aged 14 years and a girl aged 12 years presented themselves, each, with a single hypopigmented, hypoesthetic patch on the face. Clinically leprosy was suspected, however, skin biopsy from both patients revealed follicular mucinosis as the only pathological finding, without any granulomas. Based on clinical suspicion both were started on multi drug therapy (MDT for leprosy with complete resolution of the lesions. The third case, male, aged 22 years presented with a single erythematous, hypoesthetic plaque on the forehead.This lesion had been diagnosed as follicular mucinosis with folliculo-tropic mycosis fungoides, in the USA. He too responded completely within 3 months with rifampicin, ofloxacin, minocycline (ROM treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year. Follicular mucinosis as the only pathology may be seen in facial lesions of clinically suspected leprosy in children and young adults. Based on histological findings these cannot be diagnosed as leprosy and will be considered as Alopecia mucinosa. These lesions, however, are always single and show rapid and complete response to antileprosy treatment. The authors suggest that in regions endemic for leprosy, such as India, single lesion Alopecia mucinosa on the face in children and young adults should be given antileprosy treatment.


    Directory of Open Access Journals (Sweden)

    A. Madani


    Full Text Available Some patients with the diagnosis of childhood nephrotic syndrome are unresponsive to conventional treatment regimens. Recent studies of more aggressive therapies have provided strong evidence of the benefit of high dose methylprednisolonc (MP protocol with alternate - day prednisone alone or with alternate - day prednisone plus an alkylating agent (I in these patients."nFrom May 1996 to May 1997 we have treated 14 patients with non-responder nephrotic syndrome with mcthyprcdnisolone protocol. Eight patients had histologic diagnosis of focal segmental glomerulosclerosis, 3 diffuse mesangial proliferation and 3 has minimal change disease. C'ylosporin was added in two patients to methylprcdnisotonc at the beginning of the second course of therapy. Tfie patients were observed for an average of 8 months (range 4-12 months. In the last follow up there were no patients in remission and all remained nephrotic. Seven patients had persistent massive proteinuria with normal creatinine clearance (CrCI. Two had decreased CrCl. Five progressed to end-stage renal disease. Tlicsc observations suggest that "Puke" methy{prednisolone is not effective in patients with non respondcr nephrotic syndrome.

  18. Accelerated maternal responding following intra-VTA pertussis toxin treatment. (United States)

    Byrnes, John J; Gleason, Erin D; Schoen, Matthew K; Schoen, Mathew T; Lovelock, Dennis F; Carini, Lindsay M; Byrnes, Elizabeth M; Bridges, Robert S


    Prior studies have supported a role for mesolimbic dopaminergic mechanisms in the regulation of maternal behavior. Accordingly, the ventral tegmental area (VTA) and its dopaminergic projections to the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) have been implicated in both the onset and maintenance of normal maternal behavior. To date, studies of direct manipulation of VTA neurochemistry at the onset of maternal behavior have been limited. The current study was undertaken to directly test the hypothesis that enhancement of dopaminergic transmission in the mesolimbic dopamine system can stimulate maternal activity using a pup-induced virgin model. Nulliparous female rats were stereotaxically infused with pertussis toxin (PTX 0, 0.1, or 0.3 μg/hemisphere) into the VTA to chronically stimulate the activity of dopaminergic projection neurons. After 3 days of recovery, maternal responding to donor pups was tested daily, and latency (in days) to full maternal behavior was recorded. Intra-VTA PTX treatment produced a robust dose-dependent decrease in maternal behavior latency, and a long-lasting increase in locomotor activity. These effects were associated with significantly decreased dopamine D1 receptor mRNA expression in the NAc. No effects of PTX treatment on mesolimbic dopamine utilization or mPFC receptor expression were observed. The findings indicate that chronic neural activation in the VTA accelerates the onset of maternal behavior in virgin female rats via modification of the NAc dopamine D1 receptor.

  19. Management of Poor Responders in IVF: Is There Anything New?

    Directory of Open Access Journals (Sweden)

    Filippo Ubaldi


    Full Text Available Despite the fact that in the last two decades an enormous number of papers on the topic of poor ovarian response have been published in the literature, so far it has been impossible to identify any efficient treatment to improve the ovarian response and the clinical outcome of this group of patients. The incidence of poor ovarian responders among infertile women has been estimated at 9–24% but according to recent reviews, it seems to have slightly increased. The limitation in quantifying the incidence of these patients among the infertile population is due to the difficulty of a clear definition in literature. A recent paper by the Bologna ESHRE working group on poor ovarian response has been the first real attempt to find a common definition. Current literature proposes new risk factors which could be the cause of a reduction in ovarian reserve, which also includes genetic factors. This represents the first necessary step towards finding applicable solutions for these patients. To date, there is a substantial lack of literature that identifies an ideal protocol for these patients. The use of the “Bologna criteria” and the introduction of long acting gonadotropin in clinical practice have given rise to new promising stimulation protocols for this group of patients.

  20. Peripheral Sensory Neurons Expressing Melanopsin Respond to Light (United States)

    Matynia, Anna; Nguyen, Eileen; Sun, Xiaoping; Blixt, Frank W.; Parikh, Sachin; Kessler, Jason; Pérez de Sevilla Müller, Luis; Habib, Samer; Kim, Paul; Wang, Zhe Z.; Rodriguez, Allen; Charles, Andrew; Nusinowitz, Steven; Edvinsson, Lars; Barnes, Steven; Brecha, Nicholas C.; Gorin, Michael B.


    The ability of light to cause pain is paradoxical. The retina detects light but is devoid of nociceptors while the trigeminal sensory ganglia (TG) contain nociceptors but not photoreceptors. Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to mediate light-induced pain but recent evidence raises the possibility of an alternative light responsive pathway independent of the retina and optic nerve. Here, we show that melanopsin is expressed in both human and mouse TG neurons. In mice, they represent 3% of small TG neurons that are preferentially localized in the ophthalmic branch of the trigeminal nerve and are likely nociceptive C fibers and high-threshold mechanoreceptor Aδ fibers based on a strong size-function association. These isolated neurons respond to blue light stimuli with a delayed onset and sustained firing, similar to the melanopsin-dependent intrinsic photosensitivity observed in ipRGCs. Mice with severe bilateral optic nerve crush exhibit no light-induced responses including behavioral light aversion until treated with nitroglycerin, an inducer of migraine in people and migraine-like symptoms in mice. With nitroglycerin, these same mice with optic nerve crush exhibit significant light aversion. Furthermore, this retained light aversion remains dependent on melanopsin-expressing neurons. Our results demonstrate a novel light-responsive neural function independent of the optic nerve that may originate in the peripheral nervous system to provide the first direct mechanism for an alternative light detection pathway that influences motivated behavior. PMID:27559310

  1. Microalgae respond differently to nitrogen availability during culturing

    Indian Academy of Sciences (India)

    Liliana G Gigova; Natalia J Ivanova


    Variations in the exogenous nitrogen level are known to significantly affect the physiological status and metabolism of microalgae. However, responses of red, green and yellow-green algae to nitrogen (N) availability have not been compared yet. Porphyridium cruentum, Scenedesmus incrassatulus and Trachydiscus minutus were cultured in the absence of N in the medium and subsequent resupply of N to the starved cells. Culture growth and in-gel changes in isoenzyme pattern and activity of glutamate synthase, glutamate dehydrogenase, malate dehydrogenase, aspartate aminotransferase, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase were studied. The results demonstrated that the algae responded to the fully N-depleted and N-replete culture conditions by species-specific metabolic enzyme changes, suggesting differential regulation of both enzyme activity and cellular metabolism. Substantial differences in the activities of the antioxidant enzymes between N-depleted and N-replete cells of each species as well as between the species were also found. In the present work, besides the more general responses, such as adjustment of growth and pigmentation, we report on the involvement of specific metabolic and antioxidant enzymes and their isoforms in the mechanisms operating during N starvation and recovery in P. cruentum, T. minutus and S. incrassatulus.

  2. Network Structure and Biased Variance Estimation in Respondent Driven Sampling.

    Directory of Open Access Journals (Sweden)

    Ashton M Verdery

    Full Text Available This paper explores bias in the estimation of sampling variance in Respondent Driven Sampling (RDS. Prior methodological work on RDS has focused on its problematic assumptions and the biases and inefficiencies of its estimators of the population mean. Nonetheless, researchers have given only slight attention to the topic of estimating sampling variance in RDS, despite the importance of variance estimation for the construction of confidence intervals and hypothesis tests. In this paper, we show that the estimators of RDS sampling variance rely on a critical assumption that the network is First Order Markov (FOM with respect to the dependent variable of interest. We demonstrate, through intuitive examples, mathematical generalizations, and computational experiments that current RDS variance estimators will always underestimate the population sampling variance of RDS in empirical networks that do not conform to the FOM assumption. Analysis of 215 observed university and school networks from Facebook and Add Health indicates that the FOM assumption is violated in every empirical network we analyze, and that these violations lead to substantially biased RDS estimators of sampling variance. We propose and test two alternative variance estimators that show some promise for reducing biases, but which also illustrate the limits of estimating sampling variance with only partial information on the underlying population social network.

  3. Estimating hidden population size using Respondent-Driven Sampling data. (United States)

    Handcock, Mark S; Gile, Krista J; Mar, Corinne M

    Respondent-Driven Sampling (RDS) is n approach to sampling design and inference in hard-to-reach human populations. It is often used in situations where the target population is rare and/or stigmatized in the larger population, so that it is prohibitively expensive to contact them through the available frames. Common examples include injecting drug users, men who have sex with men, and female sex workers. Most analysis of RDS data has focused on estimating aggregate characteristics, such as disease prevalence. However, RDS is often conducted in settings where the population size is unknown and of great independent interest. This paper presents an approach to estimating the size of a target population based on data collected through RDS. The proposed approach uses a successive sampling approximation to RDS to leverage information in the ordered sequence of observed personal network sizes. The inference uses the Bayesian framework, allowing for the incorporation of prior knowledge. A flexible class of priors for the population size is used that aids elicitation. An extensive simulation study provides insight into the performance of the method for estimating population size under a broad range of conditions. A further study shows the approach also improves estimation of aggregate characteristics. Finally, the method demonstrates sensible results when used to estimate the size of known networked populations from the National Longitudinal Study of Adolescent Health, and when used to estimate the size of a hard-to-reach population at high risk for HIV.

  4. Engineer Research and Development Center's Materials Testing Center (MTC) (United States)

    Federal Laboratory Consortium — The Engineer Research and Development Center's Materials Testing Center (MTC) is committed to quality testing and inspection services that are delivered on time and...

  5. "Infotonics Technology Center"

    Energy Technology Data Exchange (ETDEWEB)

    Fritzemeier, L. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Boysel, M. B. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Smith, D. R. [Infotonics Technology Center Inc., Canandaigua, NY (United States)


    During this grant period July 15, 2002 thru September 30, 2004, the Infotonics Technology Center developed the critical infrastructure and technical expertise necessary to accelerate the development of sensors, alternative lighting and power sources, and other specific subtopics of interest to Department of Energy. Infotonics fosters collaboration among industry, universities and government and operates as a national center of excellence to drive photonics and microsystems development and commercialization. A main goal of the Center is to establish a unique, world-class research and development facility. A state-of-the-art microsystems prototype and pilot fabrication facility was established to enable rapid commercialization of new products of particular interest to DOE. The Center has three primary areas of photonics and microsystems competency: device research and engineering, packaging and assembly, and prototype and pilot-scale fabrication. Center activities focused on next generation optical communication networks, advanced imaging and information sensors and systems, micro-fluidic systems, assembly and packaging technologies, and biochemical sensors. With targeted research programs guided by the wealth of expertise of Infotonics business and scientific staff, the fabrication and packaging facility supports and accelerates innovative technology development of special interest to DOE in support of its mission and strategic defense, energy, and science goals.

  6. Conjugated polymers that respond to oxidation with increased emission. (United States)

    Dane, Eric L; King, Sarah B; Swager, Timothy M


    Thioether-containing poly(para-phenylene-ethynylene) (PPE) copolymers show a strong fluorescence turn-on response when exposed to oxidants in solution as a result of the selective conversion of thioether substituents into sulfoxides and sulfones. We propose that the increase in fluorescence quantum yield (Phi(F)) upon oxidation is the result of both an increase in the rate of fluorescence (k(F)), as a result of greater spatial overlap of the frontier molecular orbitals in the oxidized materials, and an increase in the fluorescence lifetime (tau(F)), due to a decrease in the rate of nonradiative decay. Contrary to established literature, the reported sulfoxides do not always act as fluorescence quenchers. The oxidation is accompanied by spectral changes in the absorption and emission of the polymers, which are dramatic when oxidation causes the copolymer to acquire a donor-acceptor interaction. The oxidized polymers have high fluorescence quantum yields in the solid state, with some having increased photostability. A turn-on fluorescence response to hydrogen peroxide in organic solvents in the presence of an oxidation catalyst indicates the potential of thioether-containing materials for oxidant sensing. The reported polymers show promise as new materials in applications where photostability is important, where tunability of emission across the visible spectrum is desired, and where efficient emission is an advantage.

  7. Hospitals report on cancer centers. (United States)

    Rees, T


    Woman's Hospital, Baton Rouge, La., is first-place winner among cancer centers. Holy Cross Hospital's Michael and Dianne Bienes Comprehensive Cancer Center, Ft. Lauderdale, Fla., is named second; and, Cardinal Health System's Ball Cancer Center, Muncie, Ind., third.

  8. How does not responding to appetitive stimuli cause devaluation: Evaluative conditioning or response inhibition?

    NARCIS (Netherlands)

    Chen, Z.; Veling, H.P.; Dijksterhuis, A.J.; Holland, R.W.


    In a series of 6 experiments (5 preregistered), we examined how not responding to appetitive stimuli causes devaluation. To examine this question, a go/no-go task was employed in which appetitive stimuli were consistently associated with cues to respond (go stimuli), or with cues to not respond (eit

  9. Using Video Modeling to Teach Children with PDD-NOS to Respond to Facial Expressions (United States)

    Axe, Judah B.; Evans, Christine J.


    Children with autism spectrum disorders often exhibit delays in responding to facial expressions, and few studies have examined teaching responding to subtle facial expressions to this population. We used video modeling to train 3 participants with PDD-NOS (age 5) to respond to eight facial expressions: approval, bored, calming, disapproval,…

  10. An Evaluation of Methods to Select Respondents to Structured Job-Analysis Questionnaires. (United States)

    Green, Samuel B.; Stutzman, Thomas


    Evaluated methods for selecting respondents who would respond accurately to items on a job-analysis questionnaire. One method involved obtaining from employees measures that assessed background, performance, and organizational information. A second method involved collecting job-analysis data from all potential job-analysis respondents and…

  11. 11 CFR 111.39 - When must the respondent pay the civil money penalty? (United States)


    ... of the Commission's final determination under 11 CFR 111.37. (b) If the respondent submits a written... 11 Federal Elections 1 2010-01-01 2010-01-01 false When must the respondent pay the civil money... (2 U.S.C. 437g, 437d(a)) Administrative Fines § 111.39 When must the respondent pay the civil...

  12. The AMINO experiment: exposure of amino acids in the EXPOSE-R experiment on the International Space Station and in laboratory (United States)

    Bertrand, Marylène; Chabin, Annie; Colas, Cyril; Cadène, Martine; Chaput, Didier; Brack, Andre; Cottin, Herve


    In order to confirm the results of previous experiments concerning the chemical behaviour of organic molecules in the space environment, organic molecules (amino acids and a dipeptide) in pure form and embedded in meteorite powder were exposed in the AMINO experiment in the EXPOSE-R facility onboard the International Space Station. After exposure to space conditions for 24 months (2843 h of irradiation), the samples were returned to the Earth and analysed in the laboratory for reactions caused by solar ultraviolet (UV) and other electromagnetic radiation. Laboratory UV exposure was carried out in parallel in the Cologne DLR Center (Deutsches Zentrum für Luft und Raumfahrt). The molecules were extracted from the sample holder and then (1) derivatized by silylation and analysed by gas chromatography coupled to a mass spectrometer (GC-MS) in order to quantify the rate of degradation of the compounds and (2) analysed by high-resolution mass spectrometry (HRMS) in order to understand the chemical reactions that occurred. The GC-MS results confirm that resistance to irradiation is a function of the chemical nature of the exposed molecules and of the wavelengths of the UV light. They also confirm the protective effect of a coating of meteorite powder. The most altered compounds were the dipeptides and aspartic acid while the most robust were compounds with a hydrocarbon chain. The MS analyses document the products of reactions, such as decarboxylation and decarbonylation of aspartic acid, taking place after UV exposure. Given the universality of chemistry in space, our results have a broader implication for the fate of organic molecules that seeded the planets as soon as they became habitable as well as for the effects of UV radiation on exposed molecules at the surface of Mars, for example.

  13. Standardized Index of Shape (SIS): a quantitative DCE-MRI parameter to discriminate responders by non-responders after neoadjuvant therapy in LARC

    Energy Technology Data Exchange (ETDEWEB)

    Petrillo, Antonella; Fusco, Roberta; Petrillo, Mario; Granata, Vincenza [Istituto Nazionale Tumori Fondazione Giovanni Pascale - IRCCS, Naples (Italy). Div. of Radiology; Sansone, Mario [Naples Univ. ' ' Federico II' ' (Italy). Dept. of Biomedical, Electronics and Telecommunications Engineering; Avallone, Antonio [Istituto Nazionale Tumori Fondazione Giovanni Pascale - IRCCS, Naples (Italy). Div. of Gastrointestinal Medical Oncology; Delrio, Paolo [Istituto Nazionale Tumori Fondazione Giovanni Pascale - IRCCS, Naples (Italy). Div. of Gastrointestinal surgical Oncology; Pecori, Biagio [Istituto Nazionale Tumori Fondazione Giovanni Pascale - IRCCS, Naples (Italy). Div. of Radiotherapy; Tatangelo, Fabiana [Istituto Nazionale Tumori Fondazione Giovanni Pascale - IRCCS, Naples (Italy). Div. of Diagnostic Pathology; Ciliberto, Gennaro [Istituto Nazionale Tumori Fondazione Giovanni Pascale - IRCCS, Naples (Italy)


    To investigate the potential of DCE-MRI to discriminate responders from non-responders after neoadjuvant chemo-radiotherapy (CRT) for locally advanced rectal cancer (LARC). We investigated several shape parameters for the time-intensity curve (TIC) in order to identify the best combination of parameters between two linear parameter classifiers. Seventy-four consecutive patients with LARC were enrolled in a prospective study approved by our ethics committee. Each patient gave written informed consent. After surgery, pathological TNM and tumour regression grade (TRG) were estimated. DCE-MRI semi-quantitative analysis (sqMRI) was performed to identify the best parameter or parameter combination to discriminate responders from non-responders in response monitoring to CRT. Percentage changes of TIC shape descriptors from the baseline to the presurgical scan were assessed and correlated with TRG. Receiver operating characteristic analysis and linear classifier were applied. Forty-six patients (62.2 %) were classified as responders, while 28 subjects (37.8 %) were considered as non-responders. sqMRI reached a sensitivity of 93.5 % and a specificity of 82.1 % combining the percentage change in Maximum Signal Difference (ΔMSD) and Wash-out Slope (ΔWOS), the Standardized Index of Shape (SIS). SIS obtains the best result in discriminating responders from non-responders after CRT in LARC, with a cut-off value of -3.0 %. (orig.)

  14. Loss of gas from echogenic liposomes exposed to pulsed ultrasound (United States)

    Raymond, Jason L.; Luan, Ying; Peng, Tao; Huang, Shao-Ling; McPherson, David D.; Versluis, Michel; de Jong, Nico; Holland, Christy K.


    The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, \\dot{{R}}  /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency.

  15. International Water Center (United States)

    The urban district of Nancy and the Town of Nancy, France, have taken the initiative of creating an International Center of Water (Centre International de l'Eau à Nancy—NAN.C.I.E.) in association with two universities, six engineering colleges, the Research Centers of Nancy, the Rhine-Meuse Basin Agency, and the Chamber of Commerce and Industry. The aim of this center is to promote research and technology transfer in the areas of water and sanitation. In 1985 it will initiate a research program drawing on the experience of 350 researchers and engineers of various disciplines who have already been assigned to research in these fields. The research themes, the majority of which will be multidisciplinary, concern aspects of hygiene and health, the engineering of industrial processes, water resources, and the environment and agriculture. A specialist training program offering five types of training aimed at university graduates, graduates of engineering colleges, or experts, will start in October 1984.

  16. Implementing Patient Family-Centered Care Grand Rounds Using Patient/Family Advisor Narratives


    Maureen B Fagan DNP, MHA, FNP-BC; Celene Wong MHA; Martha B Carnie AS; Stanley W Ashley MD; Jacqueline G Somerville RN, PhD


    With the emerging trend of patient family–centered care in health care, it is essential that physicians be exposed to patient and family perspectives of care during medical education and training. Grand Rounds provides an ideal format for physicians to learn about patient family–centered care. At Brigham and Women’s Hospital, we sought to bring the voice of the patient to Patient Family–Centered Grand Rounds in order to expose clinicians to rich narratives describing the medical care received...

  17. Striatal dopamine (D2) receptor availability predicts socially desirable responding. (United States)

    Reeves, Suzanne J; Mehta, Mitul A; Montgomery, Andrew J; Amiras, Dimitri; Egerton, Alice; Howard, Robert J; Grasby, Paul M


    Research in non-human primates has implicated striatal dopamine (D2) receptor function in the expression of social dominance--a fundamental component of social extraversion. We predicted that trait extraversion - indexed by the revised Eysenck Personality Questionnaire (EPQ-R) - would correlate with striatal DA (D2) receptor measures - indexed by [(11)C]-Raclopride binding potential (BP) - in 28 healthy post-menopausal females (mean age=75 years; range=58-91 years). Region of interest (ROI) and voxel-based statistical parametric mapping (SPM) analyses were performed, using a reference tissue model for [(11)C]-Raclopride. ROI analysis showed moderately significant negative correlations between extraversion and BP measures in the left caudate and between psychoticism scores and BP in the right putamen. Unexpectedly, scores on the Lie scale, a measure of socially desirable responding, were significantly and negatively correlated with BP measures in the putamen and survived Bonferroni correction on the right side. After controlling for the potential confounding of self-report bias in high Lie scorers, only the correlation between Lie scores and BP measures in the right putamen remained significant. Voxel-based analysis showed only Lie scores to be significantly and negatively correlated with BP measures in the right putamen. We explored this association further by applying an ROI-based approach to data on a previously scanned sample of young adults (n=13) and found a similar pattern of association, which achieved trend level significance in the right putamen. Although unanticipated, the relationship observed between BP measures in the right putamen and Lie scores is consistent with dopaminergic involvement in socially rewarding behaviour. How this relates to dopaminergic tone will need to be further explored.

  18. Reactivity of lithium exposed graphite surface

    Energy Technology Data Exchange (ETDEWEB)

    Harilal, S.S., E-mail: [Purdue University, School of Nuclear Engineering, 400 Central Dr., West Lafayette, IN 47907 (United States); Allain, J.P.; Hassanein, A. [Purdue University, School of Nuclear Engineering, 400 Central Dr., West Lafayette, IN 47907 (United States); Hendricks, M.R. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States); Nieto-Perez, M. [CICATA-IPN, Cerro Blanco 141 Cimatario, Queretaro QRO 76090 (Mexico)


    Lithium as a plasma-facing component has many attractive features in fusion devices. We investigated chemical properties of the lithiated graphite surfaces during deposition using X-ray photoelectron spectroscopy and low-energy ion scattering spectroscopy. In this study we try to address some of the known issues during lithium deposition, viz., the chemical state of lithium on graphite substrate, oxide layer formation mechanisms, Li passivation effects over time, and chemical change during exposure of the sample to ambient air. X-ray photoelectron studies indicate changes in the chemical composition with various thickness of lithium on graphite during deposition. An oxide layer formation is noticed during lithium deposition even though all the experiments were performed in ultrahigh vacuum. The metal oxide is immediately transformed into carbonate when the deposited sample is exposed to air.

  19. Exposing calculus students to advanced mathematics (United States)

    Griffiths, Barry J.; Selcuk Haciomeroglu, Erhan


    To ensure the competitiveness of the USA in the global economy, and its role as a leader in science and engineering, it is important to cultivate the next generation of home grown mathematicians. However, while universities across the USA offer calculus classes to thousands of undergraduate students each year, very few of them go on to major in mathematics. This paper posits that one of the main reasons is that the mathematical community does not expose calculus students to the beauty and complexity of upper-level mathematics, and that by doing so before they fully commit to their programme of study, the number of students with a qualification in mathematics can be increased. The results show a significant increase in the number of students planning to add a minor in mathematics, and an increased likelihood among freshmen and sophomores to change their major.

  20. Lied Transplant Center

    Energy Technology Data Exchange (ETDEWEB)



    The Department of Energy has prepared an Environmental Assessment (DOE/EA-1143) evaluating the construction, equipping and operation of the proposed Lied Transplant Center at the University of Nebraska Medical Center in Omaha, Nebraska. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Statement in not required.

  1. Data Center Energy Retrofits


    PervilÀ, Mikko


    Within the field of computer science, data centers (DCs) are a major consumer of energy. A large part of that energy is used for cooling down the exhaust heat of the servers contained in the DCs. This thesis describes both the aggregate numbers of DCs and key flagship installations in detail. We then introduce the concept of Data Center Energy Retrofits, a set of low cost, easy to install techniques that may be used by the majority of DCs for reducing their energy consumption. The main c...

  2. User Centered Design

    DEFF Research Database (Denmark)

    Egbert, Maria; Matthews, Ben


    The interdisciplinary approach of User Centered Design is presented here with a focus on innovation in the design and use of hearing technologies as well as on the potential of innovation in interaction. This approach is geared towards developing new products, systems, technologies and practices...... based on an understanding of why so few persons with hearing loss use the highly advanced hearing technologies. In integrating Conversation Analysis (“CA”), audiology and User Centered Design, three disciplines which are collaborating together for the first time, we are addressing the following...


    Energy Technology Data Exchange (ETDEWEB)



    It is well known that beam position monitors (BPM) utilizing signals from pickup electrodes (PUE) provide good resolution and relative accuracy. The absolute accuracy (i.e. position of the orbit in the vacuum chamber) is not very good due to the various reasons. To overcome the limitation it was suggested to use magnetic centers of quadrupoles for the calibration of the BPM [1]. The proposed method provides accuracy better then 200 microns for centering of the beam position monitors using modulation of the whole quadrupole family.

  4. Xichang Satellite Launch Center

    Institute of Scientific and Technical Information of China (English)



    Xichang Satellite Launch Center(XSLC) is mainly for geosynchronous orbit launches. The main purpose of XSLC is to launch spacecraft, such as broadcasting,communications and meteorological satellites, into geo-stationary orbit.Most of the commercial satellite launches of Long March vehicles have been from Xichang Satellite Launch Center. With 20 years' development,XSLC can launch 5 kinds of launch vehicles and send satellites into geostationary orbit and polar orbit. In the future, moon exploration satellites will also be launched from XSLC.

  5. Using Poison Center Data for Postdisaster Surveillance (United States)

    Wolkin, Amy; Schnall, Amy H.; Law, Royal; Schier, Joshua


    The role of public health surveillance in disaster response continues to expand as timely, accurate information is needed to mitigate the impact of disasters. Health surveillance after a disaster involves the rapid assessment of the distribution and determinants of disaster-related deaths, illnesses, and injuries in the affected population. Public health disaster surveillance is one mechanism that can provide information to identify health problems faced by the affected population, establish priorities for decision makers, and target interventions to meet specific needs. Public health surveillance traditionally relies on a wide variety of data sources and methods. Poison center (PC) data can serve as data sources of chemical exposures and poisonings during a disaster. In the US, a system of 57 regional PCs serves the entire population. Poison centers respond to poison-related questions from the public, health care professionals, and public health agencies. The Centers for Disease Control and Prevention (CDC) uses PC data during disasters for surveillance of disaster-related toxic exposures and associated illnesses to enhance situational awareness during disaster response and recovery. Poison center data can also be leveraged during a disaster by local and state public health to supplement existing surveillance systems. Augmenting traditional surveillance data (ie, emergency room visits and death records) with other data sources, such as PCs, allows for better characterization of disaster-related morbidity and mortality. Poison center data can be used during a disaster to detect outbreaks, monitor trends, track particular exposures, and characterize the epidemiology of the event. This timely and accurate information can be used to inform public health decision making during a disaster and mitigate future disaster-related morbidity and mortality. PMID:25205009

  6. Kennedy Space Center Five Year Sustainability Plan (United States)

    Williams, Ann T.


    The Federal Government is committed to following sustainable principles. At its heart, sustainability integrates environmental, societal and economic solutions for present needs without compromising the ability of future generations to meet their needs. Building upon its pledge towards environmental stewardship, the Administration generated a vision of sustainability spanning ten goals mandated within Executive Order (EO) 13693, Planning for Federal Sustainability in the Next Decade. In November 2015, the National Aeronautics and Space Administration (NASA) responded to this EO by incorporating it into a new release of the NASA Strategic Sustainability Performance Plan (SSPP). The SSPP recognizes the importance of aligning environmental practices in a manner that preserves, enhances and strengthens NASA's ability to perform its mission indefinitely. The Kennedy Space Center (KSC) is following suit with KSC's Sustainability Plan (SP) by promoting, maintaining and pioneering green practices in all aspects of our mission. KSC's SP recognizes that the best sustainable solutions use an interdisciplinary, collaborative approach spanning civil servant and contractor personnel from across the Center. This approach relies on the participation of all employees to develop and implement sustainability endeavors connected with the following ten goals: Reduce greenhouse gas (GHG) emissions. Design, build and maintain sustainable buildings, facilities and infrastructure. Leverage clean and renewable energy. Increase water conservation. Improve fleet and vehicle efficiency and management. Purchase sustainable products and services. Minimize waste and prevent pollution. Implement performance contracts for Federal buildings. Manage electronic equipment and data centers responsibly. Pursue climate change resilience. The KSC SP details the strategies and actions that address the following objectives: Reduce Center costs. center dot Increase energy and water efficiencies. Promote smart

  7. Center for Botanical Interaction Studies (United States)

    Federal Laboratory Consortium — Research Area: Dietary Supplements, Herbs, Antioxidants Program:Centers for Dietary Supplements Research: Botanicals Description:This center will look at safety and...

  8. Data Analysis and Assessment Center (United States)

    Federal Laboratory Consortium — The DoD Supercomputing Resource Center (DSRC) Data Analysis and Assessment Center (DAAC) provides classified facilities to enhance customer interactions with the ARL...

  9. Morbidity in newborns exposed to organophosphorus pesticides

    Directory of Open Access Journals (Sweden)

    Đorđević Momčilo


    Full Text Available Introduction. Insecticides are toxines by which we destroy harmful insects. The most frequent insecticides which are used today are organophosphorus pesticides. This group of compounds make substances whose activity mechanism is based on the inhibition of acetylcho­linesterase in nerve synapsis, thus producing holynergic syndrome, resulting from the accumulation of acetylcholine which developed due to the absence of decomposition under the influence of cholinesterase. In the clinical picture of acute toxication by cholinesterase inhibitors there is a clear difference between muscarinic and nicotine effects. The basic aim of the study was to establish the effects of organophosphorus pesticides present in blood and breast milk of mothers on newborns morbidity. Material and methods. The study group consisted of 18 newborns whose mothers had isolated organophosphorus pesticides in their blood and breast­milk on the third day after delivery, and the control group consisted of 84 newborns whose mothers did not have isolated organophosphorus pesticides in their blood and breastmilk. Results. Morbidity is three times greater, often in combination with some disorders of the central nervous system, and the relative risk for its appearance is eight time greater in newborns exposed to organophosphorus pesticides. Disscusion. Disorders that appear in newborns exposed to pesticides are mutagenic, cancerogenic and neurotoxic and some agenses could disturb the immune system which is reflected in morbidity increase, primarly of the central nervous system. Conclusion. The presence of organophosphorus pesticides in blood and breast milk has negative effects on newborns. In addition to acetylcho­linesterase inhibition, organophosphorus pesticides react by means of other mechanisms as well.

  10. Low levels of estradiol are associated with elevated conditioned responding during fear extinction and with intrusive memories in daily life. (United States)

    Wegerer, Melanie; Kerschbaum, Hubert; Blechert, Jens; Wilhelm, Frank H


    Posttraumatic stress disorder (PTSD) can be conceptualized as a disorder of emotional memory showing strong (conditioned) responses to trauma reminders and intrusive memories among other symptoms. Women are at greater risk of developing PTSD than men. Recent studies have demonstrated an influence of ovarian steroid hormones in both fear conditioning and intrusive memory paradigms. However, although intrusive memories are considered non-extinguished emotional reactions to trauma reminders, none of the previous studies has investigated effects of ovarian hormones on fear conditioning mechanisms and intrusive memories in conjunction. This may have contributed to an overall inconsistent picture of the role of these hormones in emotional learning and memory. To remedy this, we exposed 37 healthy women with a natural menstrual cycle (during early follicular or luteal cycle phase) to a novel conditioned-intrusion paradigm designed to model real-life traumatic experiences. The paradigm included a differential fear conditioning procedure with short violent film clips as unconditioned stimuli. Intrusive memories about the film clips were assessed ambulatorily on subsequent days. Women with lower levels of estradiol displayed elevated differential conditioned skin conductance responding during fear extinction and showed stronger intrusive memories. The inverse relationship between estradiol and intrusive memories was at least partially accounted for by the conditioned responding observed during fear extinction. Progesterone levels were not associated with either fear acquisition/extinction or with intrusive memories. This suggests that lower levels of estradiol might promote stronger symptoms of PTSD through associative processes.

  11. National Center for Standards and Certification Information: Service and programs (United States)

    Overman, Joanne


    The National Center for Standards and Certification Information (NCSCI) provides information on U.S., foreign and international voluntary standards, government regulations, and conformity assessment procedures for non-agricultural products. The Center serves as a referral service and focal point in the United States for information on standards and standards-related information. NCSCI staff respond to inquiries, maintain a reference collection of standards and standards-related documents, and serve as the U.S. inquiry point for information to and from foreign countries.

  12. 7 CFR 28.37 - Exposing of samples for classification. (United States)


    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Exposing of samples for classification. 28.37 Section... Standards Act Classification § 28.37 Exposing of samples for classification. Classification shall not proceed until the samples, after being delivered to the Classing Office, shall have been exposed for...

  13. 46 CFR 116.960 - Guards for exposed hazards. (United States)


    ... 46 Shipping 4 2010-10-01 2010-10-01 false Guards for exposed hazards. 116.960 Section 116.960 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Rails and Guards § 116.960 Guards for exposed hazards. An exposed hazard, such as gears...

  14. 7 CFR 27.33 - Exposing of samples for classification. (United States)


    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Exposing of samples for classification. 27.33 Section... Micronaire Determinations § 27.33 Exposing of samples for classification. Classification shall not proceed until the samples, after being delivered to the Marketing Services Office, shall have been exposed...

  15. Estimating the number of children exposed to parental psychiatric disorders through a national health survey

    Directory of Open Access Journals (Sweden)

    Padoin Cintia V


    Full Text Available Abstract Objective Children whose parents have psychiatric disorders experience an increased risk of developing psychiatric disorders, and have higher rates of developmental problems and mortality. Assessing the size of this population is important for planning of preventive strategies which target these children. Methods National survey data (CCHS 1.2 was used to estimate the number of children exposed to parental psychiatric disorders. Disorders were diagnosed using the World Psychiatric Health Composite International Diagnostic Interview (WMH-CIDI (12 month prevalence. Data on the number of children below 12 years of age in the home, and the relationship of the respondents with the children, was used to estimate exposure. Parent-child relations were identified, as was single parenthood. Using a design-based analysis, the number of children exposed to parental psychiatric disorders was calculated. Results Almost 570,000 children under 12 live in households where the survey respondent met criteria for one or more mood, anxiety or substance use disorders in the previous 12 months, corresponding to 12.1% of Canadian children under the age of 12. Almost 3/4 of these children have parents that report receiving no mental health care in the 12 months preceding the survey. For 17% of all Canadian children under age 12, the individual experiencing a psychiatric disorder is the only parent in the household. Conclusion The high number of children exposed causes major concern and has important implications. Although these children will not necessarily experience adversities, they possess an elevated risk of accidents, mortality, and of developing psychiatric disorders. We expect these estimates will promote further research and stimulate discussion at both health policy and planning tables.

  16. Distinct epidermal keratinocytes respond to extremely low-frequency electromagnetic fields differently.

    Directory of Open Access Journals (Sweden)

    Chao-Ying Huang

    Full Text Available Following an increase in the use of electric appliances that can generate 50 or 60 Hz electromagnetic fields, concerns have intensified regarding the biological effects of extremely low-frequency electromagnetic fields (ELF-EMFs on human health. Previous epidemiological studies have suggested the carcinogenic potential of environmental exposure to ELF-EMFs, specifically at 50 or 60 Hz. However, the biological mechanism facilitating the effects of ELF-EMFs remains unclear. Cellular studies have yielded inconsistent results regarding the biological effects of ELF-EMFs. The inconsistent results might have been due to diverse cell types. In our previous study, we indicated that 1.5 mT, 60 Hz ELF-EMFs will cause G1 arrest through the activation of the ATM-Chk2-p21 pathway in human keratinocyte HaCaT cells. The aim of the current study was to investigate whether ELF-EMFs cause similar effects in a distinct epidermal keratinocyte, primary normal human epidermal keratinocytes (NHEK, by using the same ELF-EMF exposure system and experimental design. We observed that ELF-EMFs exerted no effects on cell growth, cell proliferation, cell cycle distribution, and the activation of ATM signaling pathway in NHEK cells. We demonstrated that the 2 epidermal keratinocytes responded to ELF-EMFs differently. To further validate this finding, we simultaneously exposed the NHEK and HaCaT cells to ELF-EMFs in the same incubator for 168 h and observed the cell growths. The simultaneous exposure of the two cell types results showed that the NHEK and HaCaT cells exhibited distinct responses to ELF-EMFs. Thus, we confirmed that the biological effects of ELF-EMFs in epidermal keratinocytes are cell type specific. Our findings may partially explain the inconsistent results of previous studies when comparing results across various experimental models.

  17. Distinct epidermal keratinocytes respond to extremely low-frequency electromagnetic fields differently. (United States)

    Huang, Chao-Ying; Chuang, Chun-Yu; Shu, Wun-Yi; Chang, Cheng-Wei; Chen, Chaang-Ray; Fan, Tai-Ching; Hsu, Ian C


    Following an increase in the use of electric appliances that can generate 50 or 60 Hz electromagnetic fields, concerns have intensified regarding the biological effects of extremely low-frequency electromagnetic fields (ELF-EMFs) on human health. Previous epidemiological studies have suggested the carcinogenic potential of environmental exposure to ELF-EMFs, specifically at 50 or 60 Hz. However, the biological mechanism facilitating the effects of ELF-EMFs remains unclear. Cellular studies have yielded inconsistent results regarding the biological effects of ELF-EMFs. The inconsistent results might have been due to diverse cell types. In our previous study, we indicated that 1.5 mT, 60 Hz ELF-EMFs will cause G1 arrest through the activation of the ATM-Chk2-p21 pathway in human keratinocyte HaCaT cells. The aim of the current study was to investigate whether ELF-EMFs cause similar effects in a distinct epidermal keratinocyte, primary normal human epidermal keratinocytes (NHEK), by using the same ELF-EMF exposure system and experimental design. We observed that ELF-EMFs exerted no effects on cell growth, cell proliferation, cell cycle distribution, and the activation of ATM signaling pathway in NHEK cells. We demonstrated that the 2 epidermal keratinocytes responded to ELF-EMFs differently. To further validate this finding, we simultaneously exposed the NHEK and HaCaT cells to ELF-EMFs in the same incubator for 168 h and observed the cell growths. The simultaneous exposure of the two cell types results showed that the NHEK and HaCaT cells exhibited distinct responses to ELF-EMFs. Thus, we confirmed that the biological effects of ELF-EMFs in epidermal keratinocytes are cell type specific. Our findings may partially explain the inconsistent results of previous studies when comparing results across various experimental models.

  18. User-Centered Design through Learner-Centered Instruction (United States)

    Altay, Burçak


    This article initially demonstrates the parallels between the learner-centered approach in education and the user-centered approach in design disciplines. Afterward, a course on human factors that applies learner-centered methods to teach user-centered design is introduced. The focus is on three tasks to identify the application of theoretical and…

  19. Economics of data center optics (United States)

    Huff, Lisa


    Traffic to and from data centers is now reaching Zettabytes/year. Even the smallest of businesses now rely on data centers for revenue generation. And, the largest data centers today are orders of magnitude larger than the supercomputing centers of a few years ago. Until quite recently, for most data center managers, optical data centers were nice to dream about, but not really essential. Today, the all-optical data center - perhaps even an all-single mode fiber (SMF) data center is something that even managers of medium-sized data centers should be considering. Economical transceivers are the key to increased adoption of data center optics. An analysis of current and near future data center optics economics will be discussed in this paper.

  20. Activities of the NEDO information center

    Energy Technology Data Exchange (ETDEWEB)



    Under the situation where items of information related to energy and industrial technologies (including environmental technologies) are diversified and internationalized, the NEDO Information Center opens its book and data rooms, performs database service and information exchange activities with other countries, and issues information journals. These activities are intended to respond accurately and quickly to users` information needs. This paper reports the result of operations during fiscal 1994. Retained and provided for public reading at the Center are 2,200 reports on results of research and development works having been carried out by NEDO, 3,800 books and data published inside and outside Japan mainly on new energies, and 190 kinds of periodical publications. The first nationwide geothermal result charts are also reproduced and sold. Technological literature and information prepared by IEA which have been obtained based on the energy technological data exchange treaty and the implementation treaty on establishment of IEA coal research have been recorded as the NEDO-EDBS and offered on line. This paper also introduces the optical databases. The agreement on the IEA Information Centers for the Analysis and Dissemination of Demonstrated Energy Technologies (CADDET) is also available. Descriptions are given also on activities of the Greenhouse Gas Technology Information Exchange (GREENTIE).

  1. vCenter troubleshooting

    CERN Document Server

    Mills, Chuck


    The book is designed for the competent vCenter administrator or anyone who is responsible for the vSphere environment. It can be used as a guide by vSphere architects and VMware consultants for a successful vSphere solution. You should have good knowledge and an understanding of core elements and applications of the vSphere environment.

  2. Mobile PET Center Project (United States)

    Ryzhikova, O.; Naumov, N.; Sergienko, V.; Kostylev, V.


    Positron emission tomography is the most promising technology to monitor cancer and heart disease treatment. Stationary PET center requires substantial financial resources and time for construction and equipping. The developed mobile solution will allow introducing PET technology quickly without major investments.

  3. Data Center Site Redundancy


    Brotherton, H M; Dietz, J. Eric


    Commonly, disaster contingency calls for separation of location for redundant locations to maintain the needed redundancy. This document addresses issues for the data center redundancy, including limits to the distribution, distance and location that may impact on the efficiency or energy.

  4. Alternative Fuels Data Center

    Energy Technology Data Exchange (ETDEWEB)



    Fact sheet describes the Alternative Fuels Data Center, which provides information, data, and tools to help fleets and other transportation decision makers find ways to reduce petroleum consumption through the use of alternative and renewable fuels, advanced vehicles, and other fuel-saving measures.

  5. School Based Health Centers (United States)

    Children's Aid Society, 2012


    School Based Health Centers (SBHC) are considered by experts as one of the most effective and efficient ways to provide preventive health care to children. Few programs are as successful in delivering health care to children at no cost to the patient, and where they are: in school. For many underserved children, The Children's Aid Society's…

  6. Carolinas Energy Career Center

    Energy Technology Data Exchange (ETDEWEB)

    Classens, Anver; Hooper, Dick; Johnson, Bruce


    Central Piedmont Community College (CPCC), located in Charlotte, North Carolina, established the Carolinas Energy Career Center (Center) - a comprehensive training entity to meet the dynamic needs of the Charlotte region's energy workforce. The Center provides training for high-demand careers in both conventional energy (fossil) and renewable energy (nuclear and solar technologies/energy efficiency). CPCC completed four tasks that will position the Center as a leading resource for energy career training in the Southeast: • Development and Pilot of a New Advanced Welding Curriculum, • Program Enhancement of Non-Destructive Examination (NDE) Technology, • Student Support through implementation of a model targeted toward Energy and STEM Careers to support student learning, • Project Management and Reporting. As a result of DOE funding support, CPCC achieved the following outcomes: • Increased capacity to serve and train students in emerging energy industry careers; • Developed new courses and curricula to support emerging energy industry careers; • Established new training/laboratory resources; • Generated a pool of highly qualified, technically skilled workers to support the growing energy industry sector.

  7. Starting a sleep center. (United States)

    Epstein, Lawrence J; Valentine, Paul S


    The demand for sleep medicine services has grown tremendously during the last decade and will likely continue. To date, growth in demand has been met by growth in the number of new sleep centers. The need for more new centers will be dependent on market drivers that include increasing regulatory requirements, personnel shortages, integration of home sleep testing, changes in reimbursement, a shift in emphasis from diagnostics to treatment, and an increased consumer focus on sleep. The decision to open a new center should be based on understanding the market dynamics, completing a market analysis, and developing a business plan. The business plan should include an overview of the facility, a personnel and organizational structure, an evaluation of the business environment, a financial plan, a description of services provided, and a strategy for obtaining, managing, and extending a referral base. Implementation of the business plan and successful operation require ongoing planning and monitoring of operational parameters. The need for new sleep centers will likely continue, but the shifting market dynamics indicate a greater need for understanding the marketplace and careful planning.

  8. Memorial Alexander Center

    Directory of Open Access Journals (Sweden)

    AECK Associates, Arquitectos


    Full Text Available En Atlanta, el Instituto Tecnológico de Georgia acaba de ampliar sus instalaciones deportivas, construyendo el Alexander Memorial Center. Consta este nuevo Centro de dos edificios: una pista de baloncesto cubierta y un edificio anejo con vestuarios, duchas, una pista de entrenamiento, equipos técnicos y la emisora de radio Georgia Tech W. G. S. T.

  9. Fast Responding Voltage Regulator and Dynamic VAR Compensator

    Energy Technology Data Exchange (ETDEWEB)

    Divan, Deepak [Varentec, Incorporated, San Jose, CA (United States); Moghe, Rohit [Varentec, Incorporated, San Jose, CA (United States); Tholomier, Damien [Varentec, Incorporated, San Jose, CA (United States)


    The objectives of this project were to develop a dynamic VAR compensator (DVC) for voltage regulation through VAR support to demonstrate the ability to achieve greater levels of voltage control on electricity distribution networks, and faster response compared to existing grid technology. The goal of the project was to develop a prototype Fast Dynamic VAR Compensator (Fast DVC) hardware device, and this was achieved. In addition to developing the dynamic VAR compensator device, Varentec in partnership with researchers at North Carolina State University (NCSU) successfully met the objectives to model the potential positive impact of such DVCs on representative power networks. This modeling activity validated the ability of distributed dynamic VAR compensators to provide fast voltage regulation and reactive power control required to respond to grid disturbances under high penetration of fluctuating and intermittent distributed energy resources (DERs) through extensive simulation studies. Specifically the following tasks were set to be accomplished: 1) Development of dynamic VAR compensator to support dynamic voltage variations on the grid through VAR control 2) Extensive testing of the DVC in the lab environment 3) Present the operational DVC device to the DOE at Varentec’s lab 4) Formulation of a detailed specification sheet, unit assembly document, test setup document, unit bring-up plan, and test plan 5) Extensive simulations of the DVC in a system with high PV penetration. Understanding the operation with many DVC on a single distribution system 6) Creation and submittal of quarterly and final reports conveying the design documents, unit performance data, modeling simulation charts and diagrams, and summary explanations of the satisfaction of program goals. This report details the various efforts that led to the development of the Fast DVC as well as the modeling & simulation results. The report begins with the introduction in Section II which outlines the

  10. Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine

    Institute of Scientific and Technical Information of China (English)

    Saqib; Walayat; Zohair; Ahmed; Daniel; Martin; Srinivas; Puli; Michael; Cashman; Sonu; Dhillon


    Hepatitis B virus(HBV) infection is a global health problem. It is estimated there are more than 2 billion individuals exposed to the virus and 250 million are chronically infected. Hepatitis B is the cause of more than 600000 annual deaths due to cirrhosis and hepatocellular carcinoma. An effective vaccine exists and preventative initiatives center around universal vaccination especially in those at highest risk. Effective vaccination algorithms have led to a significant decline in the development of new infections and its devastating consequences. The vaccine is administered intramuscularly in three doses, with 95% showing long lasting serologic immunity. An additional fourth dose or a repeated higher dose three course regimen is given to those that fail to show immunity. Despite these additional regimens, some remain vulnerable to hepatitis B and are deemed nonresponders. Individuals with chronic disease states such as kidney disease, liver disease, diabetes mellitus, as well as those with a genetic predisposition, and those on immunomodulation therapy, have the highest likelihood of non-response. Various strategies have been developed to elicit an immune response in these individuals. These include increased vaccination dose, intradermal administration, alternative adjuvants, alternative routes of administration, co-administration with other vaccines, and other novel therapies. These alternative strategies can show improved response and lasting immunity. In summary, HBV vaccination is a major advance of modern medicine and all individuals at risk should be sought and vaccinated with subsequent adequate titers demonstrated.

  11. Impact Analysis of Anti-dumping Responding on New Accounting Standards%反倾销应诉对我国会计准则影响分析

    Institute of Scientific and Technical Information of China (English)

    袁继安; 王淑川; 边保奇


    This paper analyzes the new corporation accounting principles real value on anti-dumping responding of fair value t criteria and new standards in cost accounting , exposed two key problems remained in the accounting principles.%文章分析了我国会计准则在公允价值计量属性与成本核算的新规定等方面对我国企业反倾销应诉工作的实际价值,阐明了准则在这方面仍然存在的两个关键问题。

  12. Wilderness experience in Rocky Mountain National Park 2002; report to respondents (United States)

    Schuster, Elke; Johnson, S. Shea; Taylor, Jonathan G.


    A substantial amount of backcountry (about 250,000 acres) in Rocky Mountain National Park [RMNP of the Park] may be designated as wilderness areas in the coming years. Currently, over 3 million visitors drives through the park on Trail Ridge Road, camp in designated campgrounds, day hike, etc. each year. Many of those visitors also report using the backcountry-wilderness areas that are not easily accessible by roads or trails. Use of the backcountry is growing at RMNP and is accompanied by changing visitor expectations and preferences for wilderness management. For these reasons it is of great importance for the Park to periodically assess what types of environments and conditions wilderness users seek to facilitate a quality experience. To assist in this effort, the Political Analysis and Science Assistance [PSAS] program / Fort Collins Center / U.S. Geological Survey, in close collaboration with personnel and volunteers from RMNP, as well as the Natural Resource Recreation and Tourism [NRRT] Department at Colorado State University, launched a research effort in the summer of 2002 to investigate visitorsa?? wilderness experiences in the Park. Specifically, the purpose of this research was: (1) To determine what constitutes a wilderness experience; (2) To identify important places, visual features, and sounds essential to a quality wilderness experience and; (3) To determine what aspects may detract from wilderness experience. Thus, answers to these questions should provide insight for Park managers about visitorsa?? expectation for wilderness recreation and the conditions they seek for quality wilderness experiences. Ultimately, this information can be used to support wilderness management decisions within RMNP. The social science technique of Visitor Employed Photography [VEP] was used to obtain information from visitors about wilderness experiences. Visitors were selected at random from Park-designated wilderness trails, in proportion to their use, and asked to

  13. Neurotoxicity of Acrylamide in Exposed Workers

    Directory of Open Access Journals (Sweden)

    Mariano Malaguarnera


    Full Text Available Acrylamide (ACR is a water-soluble chemical used in different industrial and laboratory processes. ACR monomer is neurotoxic in humans and laboratory animals. Subchronic exposure to this chemical causes neuropathies, hands and feet numbness, gait abnormalities, muscle weakness, ataxia, skin and in some cases, cerebellar alterations. ACR neurotoxicity involves mostly the peripheral but also the central nervous system, because of damage to the nerve terminal through membrane fusion mechanisms and tubulovescicular alterations. Nevertheless, the exact action mechanism is not completely elucidated. In this paper we have reviewed the current literature on its neurotoxicity connected to work-related ACR exposure. We have analyzed not only the different pathogenetic hypotheses focusing on possible neuropathological targets, but also the critical behavior of ACR poisoning. In addition we have evaluated the ACR-exposed workers case studies. Despite all the amount of work which have being carried out on this topic more studies are necessary to fully understand the pathogenetic mechanisms, in order to propose suitable therapies.

  14. Single authentication: exposing weighted splining artifacts (United States)

    Ciptasari, Rimba W.


    A common form of manipulation is to combine parts of the image fragment into another different image either to remove or blend the objects. Inspired by this situation, we propose a single authentication technique for detecting traces of weighted average splining technique. In this paper, we assume that image composite could be created by joining two images so that the edge between them is imperceptible. The weighted average technique is constructed from overlapped images so that it is possible to compute the gray level value of points within a transition zone. This approach works on the assumption that although splining process leaves the transition zone smoothly. They may, nevertheless, alter the underlying statistics of an image. In other words, it introduces specific correlation into the image. The proposed idea dealing with identifying these correlations is to generate an original model of both weighting function, left and right functions, as references to their synthetic models. The overall process of the authentication is divided into two main stages, which are pixel predictive coding and weighting function estimation. In the former stage, the set of intensity pairs {Il,Ir} is computed by exploiting pixel extrapolation technique. The least-squares estimation method is then employed to yield the weighted coefficients. We show the efficacy of the proposed scheme on revealing the splining artifacts. We believe that this is the first work that exposes the image splining artifact as evidence of digital tampering.

  15. Thyroid hormones in chronic heat exposed men (United States)

    Gertner, A.; Israeli, R.; Lev, A.; Cassuto, Y.


    Previous reports have indicated that thyroid gland activity, is depressed in the heat. Total thyroxine (T4) and triiodothyronine (T3) serum levels in 17 workers of the metal work shop at a plant near the Dead Sea and 8 workers in Beer Sheva, Israel were examined. The metal workshop of the plant near the Dead Sea is part of a large chemical plant. The one in Beer Sheva is part of a large construction company. Maintenance work, as well as metal work projects are performed in both workshops. During the work shifts, the workers of the Dead Sea plant were exposed to temperatures ranging from 30 36°C (May Oct.) and 14 21°C (Dec. Feb). In Beer Sheva the range was 25 32°C (June Sept.) and 10 17°C (Dec. Feb.). Total T4 was measured by competitive protein binding and total T3 by radioimmunoassay in blood drawn before work (0700) in July and January. In summer. T4 was higher and T3 was lower for both groups than in winter. The observed summer T3 decrease may result from depressed extrathyroidal conversion of T4 to T3. We conclude that the regulation of energy metabolism in hot climates may be related to extrathyroidal conversion of T4 to T3.

  16. Effects of Pesticides on Occupationally Exposed Humans

    Directory of Open Access Journals (Sweden)

    Stylianos M. Piperakis


    Full Text Available Pesticides are known to contain numerous genotoxic compounds; however, genotoxicity biomonitoring studies of workers occupationally exposed to pesticides have produced variable results. In this study, we employed the Comet assay to examine DNA damage in peripheral blood lymphocytes (PBLs from 64 greenhouse workers from Almería in south-eastern Spain in comparison to PBLs from 50 men from the same area but not engaged in any agricultural work. The results indicated that there were no differences in the basal levels of DNA damage in the two study groups. In addition, exposure of PBL from the workers and controls to hydrogen peroxide or γ-irradiation led to similar levels of DNA damage; the subsequent repair of the induced DNA damage was also similar for both study populations. Smoking had no impact on any of the responses. The results of this study indicate that the greenhouse workers had no detectable increase in DNA damage or alteration in the cellular response to DNA damage compared to our control population.

  17. Exposing the “One China” Principle

    Directory of Open Access Journals (Sweden)

    Chien-yuan Tseng


    Full Text Available In 1992, when the governments from both sides across the Taiwan Strait began having contacts, both of them, at the People’s Republic of China (PRC’s request, expressed verbally, and in relation to functional issues, that they advocated the “one China” principle, though what “one China” actually meant was open to different interpretations, and the shift that elevated the 1992 “one China” interpretations from the functional level to the political level did not occur until April 2005. Since President Tsai Ing-wen was sworn in and the Democratic Progressive Party (DPP became the ruling party of the Republic of China (ROC on Taiwan in early 2016, the PRC has used Tsai’s rejection of this so-called “1992 consensus” as a pretext to discontinue all intergovernmental communication channels with the ROC on Taiwan, while also cutting down on cross-strait civil exchanges in travel and education. This thinkpiece article aims to scrutinise this “one China” principle, how it has developed over the years, and expose its underlying realities.

  18. Beaked whales respond to simulated and actual navy sonar. (United States)

    Tyack, Peter L; Zimmer, Walter M X; Moretti, David; Southall, Brandon L; Claridge, Diane E; Durban, John W; Clark, Christopher W; D'Amico, Angela; DiMarzio, Nancy; Jarvis, Susan; McCarthy, Elena; Morrissey, Ronald; Ward, Jessica; Boyd, Ian L


    Beaked whales have mass stranded during some naval sonar exercises, but the cause is unknown. They are difficult to sight but can reliably be detected by listening for echolocation clicks produced during deep foraging dives. Listening for these clicks, we documented Blainville's beaked whales, Mesoplodon densirostris, in a naval underwater range where sonars are in regular use near Andros Island, Bahamas. An array of bottom-mounted hydrophones can detect beaked whales when they click anywhere within the range. We used two complementary methods to investigate behavioral responses of beaked whales to sonar: an opportunistic approach that monitored whale responses to multi-day naval exercises involving tactical mid-frequency sonars, and an experimental approach using playbacks of simulated sonar and control sounds to whales tagged with a device that records sound, movement, and orientation. Here we show that in both exposure conditions beaked whales stopped echolocating during deep foraging dives and moved away. During actual sonar exercises, beaked whales were primarily detected near the periphery of the range, on average 16 km away from the sonar transmissions. Once the exercise stopped, beaked whales gradually filled in the center of the range over 2-3 days. A satellite tagged whale moved outside the range during an exercise, returning over 2-3 days post-exercise. The experimental approach used tags to measure acoustic exposure and behavioral reactions of beaked whales to one controlled exposure each of simulated military sonar, killer whale calls, and band-limited noise. The beaked whales reacted to these three sound playbacks at sound pressure levels below 142 dB re 1 µPa by stopping echolocation followed by unusually long and slow ascents from their foraging dives. The combined results indicate similar disruption of foraging behavior and avoidance by beaked whales in the two different contexts, at exposures well below those used by regulators to define

  19. Entanglement with Centers

    CERN Document Server

    Ma, Chen-Te


    Entanglement is a physical phenomenon that each state cannot be described individually. Entanglement entropy gives quantitative understanding to the entanglement. We use decomposition of the Hilbert space to discuss properties of the entanglement. Therefore, partial trace operator becomes important to define the reduced density matrix from different centers, which commutes with all elements in the Hilbert space, corresponding to different entanglement choices or different observations on entangling surface. Entanglement entropy is expected to satisfy the strong subadditivity. We discuss decomposition of the Hilbert space for the strong subadditivity and other related inequalities. The entanglement entropy with centers can be computed from the Hamitonian formulations systematically, provided that we know wavefunctional. In the Hamitonian formulation, it is easier to obtain symmetry structure. We consider massless $p$-form theory as an example. The massless $p$-form theory in ($2p+2)$-dimensions has global symm...

  20. Home media center


    Valverde Martinez, Juan Miguel


    One of the most popular indoor entertainment systems nowadays is related to playing multimedia files, not only at home but also in public events such as watching movies in cinemas or playing music in nightclubs or pubs. Developers are responsible for making this easier and innovating in the development of these systems in different ways. This project's goal was to develop a home media center which allows the user to play multimedia files easily. In addition, the development was intended t...


    Energy Technology Data Exchange (ETDEWEB)



    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security.

  2. Comparative Toxicological Study between Exposed and Non-Exposed Farmers to Organophosphorus Pesticides

    Directory of Open Access Journals (Sweden)

    Fariba Taghavian


    Full Text Available Objective: The purpose of this work was to compare DNA damage, acetylcholinesterase (AChE activity, inflammatory markers and clinical symptoms in farmers exposed to organophosphorus pesticides to individuals that had no pesticide exposure. Materials and Methods: We conducted a cross-sectional survey with a total of 134 people. The subject group consisted of 67 farmers who were exposed to organophosphorus pesticides. The control group consisted of 67 people without any contact with pesticides matched with the subject group in terms of age, gender, and didactics. Oxidative DNA damage, the activities of AChE, interleukin-6 (IL6, IL10 and C-reactive protein (CRP in serum were measured and clinical examinations conducted in order to register all clinical signs. Results: Compared with the control group, substantial gains were observed in the farmers’ levels of oxidative DNA damage, IL10 and CRP. There was significantly less AChE activity in farmers exposed to organophosphorus pesticides. The levels of IL6 in both groups did not significantly differ. Conclusion: The outcomes show that exposure to organophosphorus pesticides may cause DNA oxidative damage, inhibit AChE activity and increase the serum levels of inflammatory markers. Using biological materials instead of chemical pesticides and encouraging the use of safety equipment by farmers are some solutions to the adverse effects of exposure to organophosphorous pesticides.

  3. Comparative Toxicological Study between Exposed and Non-Exposed Farmers to Organophosphorus Pesticides (United States)

    Taghavian, Fariba; Vaezi, Gholamhassan; Abdollahi, Mohammad; Malekirad, Ali Akbar


    Objective The purpose of this work was to compare DNA damage, acetylcholinesterase (AChE) activity, inflammatory markers and clinical symptoms in farmers exposed to organophosphorus pesticides to individuals that had no pesticide exposure. Materials and Methods We conducted a cross-sectional survey with a total of 134 people. The subject group consisted of 67 farmers who were exposed to organophosphorus pesticides. The control group consisted of 67 people without any contact with pesticides matched with the subject group in terms of age, gender, and didactics. Oxidative DNA damage, the activities of AChE, interleukin-6 (IL6), IL10 and C-reactive protein (CRP) in serum were measured and clinical examinations conducted in order to register all clinical signs. Results Compared with the control group, substantial gains were observed in the farmers’ levels of oxidative DNA damage, IL10 and CRP. There was significantly less AChE activity in farmers exposed to organophosphorus pesticides. The levels of IL6 in both groups did not significantly differ. Conclusion The outcomes show that exposure to organophosphorus pesticides may cause DNA oxidative damage, inhibit AChE activity and increase the serum levels of inflammatory markers. Using biological materials instead of chemical pesticides and encouraging the use of safety equipment by farmers are some solutions to the adverse effects of exposure to organophosphorous pesticides. PMID:27054123

  4. NASA Space Engineering Research Center for VLSI systems design (United States)


    This annual review reports the center's activities and findings on very large scale integration (VLSI) systems design for 1990, including project status, financial support, publications, the NASA Space Engineering Research Center (SERC) Symposium on VLSI Design, research results, and outreach programs. Processor chips completed or under development are listed. Research results summarized include a design technique to harden complementary metal oxide semiconductors (CMOS) memory circuits against single event upset (SEU); improved circuit design procedures; and advances in computer aided design (CAD), communications, computer architectures, and reliability design. Also described is a high school teacher program that exposes teachers to the fundamentals of digital logic design.

  5. North American neonatal extracorporeal membrane oxygenation (ECMO) devices and team roles: 2008 survey results of Extracorporeal Life Support Organization (ELSO) centers. (United States)

    Lawson, D Scott; Lawson, Andrea F; Walczak, Rich; McRobb, Craig; McDermott, Patty; Shearer, Ian R; Lodge, Andrew; Jaggers, James


    In early 2008, surveys of active extracorporeal membrane oxygenation (ECMO) centers in North America were conducted by electronic mail regarding neonatal ECMO equipment and professional staff. Eighty of 103 (78%) North American ECMO centers listed in the Extracorporeal Life Support Organization directory as neonatal centers responded to the survey. Of the responding centers, 82.5% routinely used roller pumps for neonatal ECMO, and the remaining 17.5% used centrifugal pumps. Silicone membrane oxygenators were used by 67% of the respondents, whereas 19% used micro-porous hollow fiber oxygenators, and 14% used polymethylpentene hollow fiber oxygenators. Of the silicone membrane oxygenator users, 86% used the Medtronic Ecmotherm heat exchanger, 10% used the Gish HE-4 heat exchanger, and 4% used the Terumo Conducer device. Sixty-four percent of the responding centers used some form of in-line blood gas monitoring. Six percent of the centers used a bubble trap in the arterial line, and 5% used an arterial line filter. A bladder was used by 85% of the centers, and 4% of these used a mechanical bladder box for servo regulation; the remaining 96% used pressure servo regulation. An air bubble detector was used by 88% of the responding centers. A surface coating was used by 44% of the centers on all their neonatal ECMO patients. Thirty-one percent of the centers use an activated clotting time of 180-220 seconds. At 54% of the responding centers, perfusionists were involved with the ECMO program, registered nurses were involved at 70% of the centers, and respiratory therapists were involved at 46% of the centers. Compared with a 2002 survey, silicone membrane use is declining, and the use of centrifugal blood pumps and coated ECMO circuits is becoming more apparent. ECMO teams are still multidisciplinary, made up of combinations of registered nurses, respiratory therapists, and perfusionists.

  6. Potent neutralizing serum immunoglobulin A (IgA) in human immunodeficiency virus type 2-exposed IgG-seronegative individuals

    DEFF Research Database (Denmark)

    Lizeng, Q; Nilsson, C; Sourial, S;


    Links Potent neutralizing serum immunoglobulin A (IgA) in human immunodeficiency virus type 2-exposed IgG-seronegative individuals.Lizeng Q, Nilsson C, Sourial S, Andersson S, Larsen O, Aaby P, Ehnlund M, Bjorling E. Research Center, South Hospital, Stockholm, Sweden. The mechanisms behind...... the resistance to human immunodeficiency virus type 2 (HIV-2) infection are still not fully understood. In the present study, we explored the HIV-2-specific humoral serum immunoglobulin A (IgA) immune response in HIV-2-exposed IgG-seronegative (EGSN) individuals. Serum samples from heterosexual EGSN individuals...

  7. Psychotic symptoms in young adults exposed to childhood trauma--a 20 year follow-up study. (United States)

    Galletly, Cherrie; Van Hooff, Miranda; McFarlane, Alexander


    Childhood adversity has been shown to increase the risk of psychotic symptoms in adult life. However, there are no previous studies looking at the association between experiencing a natural disaster during childhood and the development of psychotic symptoms in young adulthood. Eight hundred and six bushfire-exposed children and 725 control children were evaluated following the 1983 South Australian bushfires. Five hundred and twenty nine (65.6%) of the bushfire group and 464 (64%) controls participated in a follow up study 20 years later. Childhood data on emotional and behavioural disorders and dysfunctional parenting was available. The adult assessment included the Australian National Health and Well-Being psychosis screen and detailed information about trauma, childhood adversity and alcohol and cannabis abuse. 5.6% of subjects responded positively to the psychosis screen and 2.6% responded positively to a further probe question. Psychotic symptoms were more common in subjects exposed to a greater number of traumas, and were associated with higher rates of childhood adversity, emotional and behavioural disturbance, dysfunctional parenting, and alcohol and cannabis abuse. Subjects exposed to bushfires as children did not have a greater risk of psychosis. Our results indicate that exposure to multiple traumas, rather than a single major trauma, increases the risk of later psychosis.

  8. Implementing Patient Family-Centered Care Grand Rounds Using Patient/Family Advisor Narratives

    Directory of Open Access Journals (Sweden)

    Maureen B Fagan DNP, MHA, FNP-BC


    Full Text Available With the emerging trend of patient family–centered care in health care, it is essential that physicians be exposed to patient and family perspectives of care during medical education and training. Grand Rounds provides an ideal format for physicians to learn about patient family–centered care. At Brigham and Women’s Hospital, we sought to bring the voice of the patient to Patient Family–Centered Grand Rounds in order to expose clinicians to rich narratives describing the medical care received by patients/families and to ultimately change physician practice to reflect patient family–centered principles. We conducted a clinician survey and found promising results indicating that patient/family narratives can be effective at educating physicians about patient family–centered care.

  9. Degradation of HEPA filters exposed to DMSO

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, W.; Wilson, K.; Larsen, G. [Lawrence Livermore National Laboratory, CA (United States)] [and others


    Dimethyl sulfoxide (DMSO) sprays are being used to remove the high explosive (HE) from nuclear weapons in the process of their dismantlement. A boxed 50 cmf HEPA filter with an integral prefilter was exposed to DMSO vapor and aerosols that were generated by a spray nozzle to simulate conditions expected in the HE dissolution operation. After 198 hours of operation, the pressure drop of the filter had increased form 1.15 inches to 2,85 inches, and the efficiency for 0.3 {mu}m dioctyl sebacate (DOS) aerosols decreased form 99.992% to 98.6%. Most of the DMSO aerosols had collected as a liquid pool inside the boxed HEPA. The liquid was blown out of the filter exit with 100 cmf air flow at the end of the test. Since the filter still met the minimum allowed efficiency of 99.97% after 166 hours of exposure, we recommend replacing the filter every 160 hours of operation or sooner if the pressure drop increases by 50%. Examination of the filter showed that visible cracks appeared at the joints of the wooden frame and a portion of the sealant had pulled away from the frame. Since all of the DMSO will be trapped in the first HEPA filter, the second HEPA filter should not suffer from DMSO degradation. Thus the combined efficiency for the first filter (98.6%) and the second filter (99.97%) is 99.99996% for 0.3 {mu}m particles. If the first filter is replaced prior to its degradation, each of the filters will have 99.97% efficiency, and the combined efficiency will be 99.999991%. The collection efficiency for DMSO/HE aerosols will be much higher because the particle size is much greater.

  10. Exterior exposed ductwork: Delivery effectiveness and efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Delp, W.W.; Matson, N.; Modera, M.P.


    Most of California`s light commercial buildings use air transport through ductwork for thermal distribution. The same air distribution systems are often used to provide both thermal comfort and ventilation. Some air distribution ductwork is installed on rooftops, exposed directly to the outside environment. As such, there exist potential energy penalties related to externally installed ductwork. In order to evaluate the magnitude of these penalties, a case study was conducted of a one-story community college building, located in California`s Sacramento Valley. The majority of the building`s air distribution ductwork was located on the roof. Energy-related issues studied in this case included duct-related thermal losses (duct leakage and conduction), delivery effectiveness and efficiency, thermal comfort issues and the effect of a roof retrofit (additional insulation and a reflective coating). The building in this study underwent a retrofit project involving additional insulation and a highly reflective coating applied to the roof and ducts. As part of this project, methods were developed to analyze the air distribution system effectiveness independent of the introduction of outside air through an outside air damper. A simplified model was developed to predict the effectiveness and efficiency of the distribution system. The time frame of the retrofit allowed two separate three week monitoring periods. Despite the fact that the ducts started off with a conduction efficiency of 97%, the delivery efficiency was on average only 73% (with a supply side effectiveness of 78% and return effectiveness of 92%). This is due to the losses from the ducts being located on the roof. The retrofit increased the delivery efficiency to an average of 89% (with a supply side effectiveness of 90% and return effectiveness of 99%), reducing the average energy use for conditioning by 22%. The model predicted, on average, the results within 10%, or better, of measured results.

  11. Integrity of disposable nitrile exam gloves exposed to simulated movement. (United States)

    Phalen, Robert N; Wong, Weng Kee


    Every year, millions of health care, first responder, and industry workers are exposed to chemical and biological hazards. Disposable nitrile gloves are a common choice as both a chemical and physical barrier to these hazards, especially as an alternative to natural latex gloves. However, glove selection is complicated by the availability of several types or formulations of nitrile gloves, such as low-modulus, medical grade, low filler, and cleanroom products. This study evaluated the influence of simulated movement on the physical integrity (i.e., holes) of different nitrile exam glove brands and types. Thirty glove products were evaluated out-of-box and after exposure to simulated whole-glove movement for 2 hr. In lieu of the traditional 1 L water-leak test, a modified water-leak test, standardized to detect a 0.15 ± 0.05 mm hole in different regions of the glove, was developed. A specialized air inflation method simulated bidirectional stretching and whole-glove movement. A worst-case scenario with maximum stretching was evaluated. On average, movement did not have a significant effect on glove integrity (chi-square; p=0.068). The average effect was less than 1% between no movement (1.5%) and movement (2.1%) exposures. However, there was significant variability in glove integrity between different glove types (p≤0.05). Cleanroom gloves, on average, had the highest percentage of leaks, and 50% failed the water-leak test. Low-modulus and medical grade gloves had the lowest percentages of leaks, and no products failed the water-leak test. Variability in polymer formulation was suspected to account for the observed discrepancies, as well as the inability of the traditional 1 L water-leak test to detect holes in finger/thumb regions. Unexpectedly, greater than 80% of the glove defects were observed in the finger and thumb regions. It is recommended that existing water-leak tests be re-evaluated and standardized to account for product variability.

  12. Compulsory drug detention centers in East and Southeast Asia. (United States)

    Kamarulzaman, Adeeba; McBrayer, John L


    Over the last three decades in response to a rise in substance use in the region, many countries in East and Southeast Asia responded by establishing laws and policies that allowed for compulsory detention in the name of treatment for people who use drugs. These centers have recently come under international scrutiny with a call for their closure in a Joint Statement from United Nations entities in March 2012. The UN's response was a result of concern for human rights violations, including the lack of consent for treatment and due process protections for compulsory detention, the lack of general healthcare and evidence based drug dependency treatment and in some centers, of forced labor and physical and sexual abuse (United Nations, 2012). A few countries have responded to this call with evidence of an evolving response for community-based voluntary treatment; however progress is likely going to be hampered by existing laws and policies, the lack of skilled human resource and infrastructure to rapidly establish evidence based community treatment centers in place of these detention centers, pervasive stigmatization of people who use drugs and the ongoing tensions between the abstinence-based model of treatment as compared to harm reduction approaches in many of these affected countries.

  13. Upheaval Dome, An Analogue Site for Gale Center (United States)

    Conrad, P. G.; Eignebrode, J. L.


    We propose Upheaval Dome in southeastern Utah as an impact analogue site on Earth to Mars Science Laboratory candidate landing site Gale Crater. The genesis of Upheaval Dome was a mystery for some time--originally thought to be a salt dome. The 5 km crater was discovered to possess shocked quartz and other shock metamorphic features just a few years ago, compelling evidence that the crater was formed by impact, although the structural geology caused Shoemaker and Herkenhoff to speculate an impact origin some 25 years earlier. The lithology of the crater is sedimentary. The oldest rocks are exposed in the center of the dome, upper Permian sandstones, and progressively younger units are well exposed moving outward from the center. These are Triassic sandstones, siltstones and shales, which are intruded by clastic dikes. There are also other clay-rich strata down section, as is the case with Gale Crater. There is significant deformation in the center of the crater, with folding and steeply tilted beds, unlike the surrounding Canyonlands area, which is relatively undeformed. The rock units are well exposed at Upheaval Dome, and there are shatter cones, impactite fragments, shocked quartz grains and melt rocks present. The mineral shock features suggest that the grains were subjected to dynamic pressures> 10 GPa.

  14. Rationale and design of a multicenter randomized clinical trial with memantine and dextromethorphan in ketamine-responder patients. (United States)

    Pickering, Gisèle; Pereira, Bruno; Morel, Véronique; Tiberghien, Florence; Martin, Elodie; Marcaillou, Fabienne; Picard, Pascale; Delage, Noémie; de Montgazon, Géraldine; Sorel, Marc; Roux, Delphine; Dubray, Claude


    The N-methyl-D-aspartate receptor plays an important role in central sensitization of neuropathic pain and N-methyl-D-aspartate receptor antagonists, such as ketamine, memantine and dextromethorphan may be used for persistent pain. However, ketamine cannot be repeated too often because of its adverse events. A drug relay would be helpful in the outpatient to postpone or even cancel the next ketamine infusion. This clinical trial evaluates if memantine and/or dextromethorphan given as a relay to ketamine responders may maintain or induce a decrease of pain intensity and have a beneficial impact on cognition and quality of life. This trial is a multi-center, randomized, controlled and single-blind clinical study (NCT01602185). It includes 60 ketamine responder patients suffering from neuropathic pain. They are randomly allocated to memantine, dextromethorphan or placebo. After ketamine infusion, 60 patients received either memantine (maximal dose 20 mg/day), or dextromethorphan (maximal dose 90 mg/day), or placebo for 12 weeks. The primary endpoint is pain measured on a (0-10) Numeric Rating Scale 1 month after inclusion. Secondary outcomes include assessment of neuropathic pain, sleep, quality of life, anxiety/depression and cognitive function at 2 and 3 months. Data analysis is performed using mixed models and the tests are two-sided, with a type I error set at α=0.05. This study will explore if oral memantine and/or dextromethorphan may be a beneficial relay in ketamine responders and may diminish ketamine infusion frequency. Preservation of cognitive function and quality of life is also a central issue that will be analyzed in these vulnerable patients.

  15. FirstAED emergency dispatch, global positioning of community first responders with distinct roles

    DEFF Research Database (Denmark)

    Henriksen, Finn Lund; Schorling, Per; Hansen, Bruno;


    their roles in a team structure to reduce response times, ensure citizens' safety and offer equal possibility of early defibrillation. First aid is provided by community first responders who use their smartphone. FirstAED global positioning system (GPS)-tracks the nine nearby first responders and enables...... the emergency dispatcher to send an organised team of three first responders with distinct roles to the scene automatically. During the first 24 months the FirstAED system was used 718 times. Three first responders arrived in ∼89% of the cases, and they arrived before the ambulance in ∼94% of the cases. First...

  16. Memorial Center - Milwaukee

    Directory of Open Access Journals (Sweden)

    Saarinen, Eero


    Full Text Available El Memorial Center de Milwaukee ha sido erigido en la parte más alta de la ciudad, coronando una enorme colina que domina ampliamente el conjunto urbano y un hermoso lago. Su emplazamiento, al final de un puente de grandes dimensiones, exigía que fuese tratado en armonía con éste, habiéndose adoptado por ello el sistema de colocar la edificación reposando sobre una planta totalmente diáfana que deja vista la estructura, cuyos esbeltos soportes dan sensación de monumentalidad.


    Energy Technology Data Exchange (ETDEWEB)



    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  18. Educator Sexual Misconduct: Exposing or Causing Learners to Be Exposed to Child Pornography or Pornography

    Directory of Open Access Journals (Sweden)

    Susan Coetzee


    Full Text Available he law recognises that non-contact sexual offences can cause harm and several offences were created to regulate non-contact sexual child abuse offences. Several of these offences deal with the exposure or causing exposure of children to child pornography or pornography. Sexual grooming of children and the “Exposure or display of or causing exposure or display of child pornography or pornography to children” are criminalised in sections 18(2 and 19 of the Criminal Law (Sexual Offences and Related Matters Amendment Act 32 of 2007. And offences in relation to exposing children to disturbing, harmful and age-inappropriate materials are criminalised in sections 24A(2 and (4 of the Films and Publications Act 65 of 1996. In this article the author considered the content of the offences of “Exposure or display of or causing exposure or display of child pornography or pornography to children” in relation to the other offences dealing with exposure of children to child pornography or pornography. Benchmarked against these criminal offences the author then conceptualised exposing learners, or causing the exposure of learners to child pornography or pornography as forms of educator misconduct. The seriousness that should be attached to these forms of misconduct was considered in light of the various criminal offences. The review of the criminal offences and the forms of educator misconduct brought the ineffectiveness of current forms of serious educator misconduct to the fore. There is no form of serious misconduct that covers the transgression of educators who expose learners to child pornography or pornography that can be classified as “XX”. In conclusion a suggestion is made with regard to how a new form of serious misconduct could be worded so as to cover this gap, eg An educator must be dismissed if he or she is found guilty of – (g exposing a learner to or causing exposure of a learner to material classified as “Refused” or

  19. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)


    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  20. Data center coolant switch

    Energy Technology Data Exchange (ETDEWEB)

    Iyengar, Madhusudan K.; Parida, Pritish R.; Schultz, Mark D.


    A data center cooling system is operated in a first mode; it has an indoor portion wherein heat is absorbed from components in the data center, and an outdoor heat exchanger portion wherein outside air is used to cool a first heat transfer fluid (e.g., water) present in at least the outdoor heat exchanger portion of the cooling system during the first mode. The first heat transfer fluid is a relatively high performance heat transfer fluid (as compared to the second fluid), and has a first heat transfer fluid freezing point. A determination is made that an appropriate time has been reached to switch from the first mode to a second mode. Based on this determination, the outdoor heat exchanger portion of the data cooling system is switched to a second heat transfer fluid, which is a relatively low performance heat transfer fluid, as compared to the first heat transfer fluid. It has a second heat transfer fluid freezing point lower than the first heat transfer fluid freezing point, and the second heat transfer fluid freezing point is sufficiently low to operate without freezing when the outdoor air temperature drops below a first predetermined relationship with the first heat transfer fluid freezing point.

  1. National Center for Biotechnology Information (United States)

    ... to NCBI Sign Out NCBI National Center for Biotechnology Information Search database All Databases Assembly BioProject BioSample ... Search Welcome to NCBI The National Center for Biotechnology Information advances science and health by providing access ...

  2. Center for Beam Physics, 1992

    Energy Technology Data Exchange (ETDEWEB)


    This report contains the following information on the center for beam physics: Facilities; Organizational Chart; Roster; Profiles of Staff; Affiliates; Center Publications (1991--1993); and 1992 Summary of Activities.

  3. Daugherty Memorial Assessment Center (DMAC) (United States)

    Federal Laboratory Consortium — Daugherty Memorial Assessment Center (DMAC) is a 39,000-square-foot facility that doubles the warfare center's high-secured performance assessment capabilities. DMAC...

  4. Italy INAF Data Center Report (United States)

    Negusini, M.; Sarti, P.


    This report summarizes the activities of the Italian INAF VLBI Data Center. Our Data Center is located in Bologna, Italy and belongs to the Institute of Radioastronomy, which is part of the National Institute of Astrophysics.

  5. VT Designated Village Centers Boundary (United States)

    Vermont Center for Geographic Information — This community revitalization program helps maintain or evolve small to medium-sized historic centers with existing civic and commercial buildings. The designation...

  6. Center for Veterinary Medicine (CVM) (United States)

    Federal Laboratory Consortium — As seen on the center's logo, the mission statement for FDA's Center for Veterinary Medicine (CVM) reads: "Protecting Human and Animal Health." To achieve this broad...

  7. Center for Prostate Disease Research (United States)

    Federal Laboratory Consortium — The Center for Prostate Disease Research is the only free-standing prostate cancer research center in the U.S. This 20,000 square foot state-of-the-art basic science...

  8. Contact Center Manager Administration (CCMA) (United States)

    Social Security Administration — CCMA is the server that provides a browser-based tool for contact center administrators and supervisors. It is used to manage and configure contact center resources...

  9. National Center on Family Homelessness (United States)

    ... You are here Home National Center on Family Homelessness Center A staggering 2.5 million children are ... raise awareness of the current state of child homelessness in the United States, documents the number of ...

  10. Exposing medical students to expanding populations

    Directory of Open Access Journals (Sweden)

    Lindenthal JJ


    Full Text Available JJ Lindenthal,1,2 JA DeLisa,3 GF Heinrich,4 WS Calderón Gerstein,5 1Department of Psychiatry, Institute for the Public Understanding of Health and Medicine, 2Department of Physical Medicine and Rehabilitation, New Jersey Medical School, Rutgers University, Newark, NJ, USA; 3Department of Orthopedics and Rehabilitation, University of New Mexico Health Science Center, Albuquerque, NM, USA; 4Department of Preventive Medicine and Community Health, New Jersey Medical School, Rutgers University, Newark, NJ, USA; 5Hospital Nacional Ramiro Prialé, EsSalud, Huancayo, Peru Abstract: Physicians are required to advocate for and counsel patients based on the best science and the interests of the individual while avoiding discrimination, ensuring equal access to health and mental services. Nonetheless, the communication gap between physician and patients has long been observed. To this end, the Institute for the Public Understanding of Health and Medicine of the Rutgers University New Jersey Medical School has expanded its efforts. This report describes two new programs: a legacy lecture series for medical students and an international “experience”, in Huancayo, Peru, for medical students and faculty. The MiniMed outreach program, now in its ninth year and first described in this journal in 2012, was designed to empower the powerless to communicate more effectively with clinicians, thus improving both the effectiveness of the physician–patient relationship and health care outcomes. The approach of the two new programs and their effects on patients, particularly the underserved, and medical students and faculty, are outlined in the following article. Keywords: MiniMed program, equal access, underserved populations, Newark Renaissance House, Kintock Group, role modeling 

  11. A comparison of metal levels and antioxidant enzymes in freshwater snails, Lymnaea natalensis, exposed to sediment and water collected from Wright Dam and Lower Mguza Dam, Bulawayo, Zimbabwe. (United States)

    Siwela, A H; Nyathi, C B; Naik, Y S


    We compared the bioaccumulation of lead (Pb), cadmium (Cd), zinc (Zn), copper (Cu), nickel (Ni) and iron (Fe) with antioxidant enzyme activity in tissues of the snails, Lymnaea natalensis, exposed to elements of two differently polluted dams. 45 snails were exposed to sediment and water collected from Wight Dam (reference) whilst another 45 snails were also exposed to sediment and water collected from Lower Mguza Dam (polluted dam). Except for Fe in sediment and Pb in water, metal concentrations were statistically higher in sediment and water collected from Lower Mguza Dam. Lead, Cd and Zn were two times higher in tissues of snails exposed to Lower Mguza Dam elements. On one hand, superoxide dismutase (SOD), diphosphotriphosphodiaphorase (DTD) and catalase (CAT) activities were significantly lower whilst malondialdehyde (MDA) levels were significantly higher in tissues of snails exposed to Lower Mguza Dam sediment and water. On the other hand, selenium-dependent glutathione peroxidase (Se-GPX) activity was significantly elevated in tissues of snails exposed to Lower Mguza Dam sediment and water. Snails exposed to Lower Mguza Dam elements seem to have responded to pollution by increasing CAT and Se-GPX specific activity in an effort to detoxify peroxides produced as a result of metal induced oxidative stress.

  12. NF-κB DNA-binding activity in embryos responding to a teratogen, cyclophosphamide

    Directory of Open Access Journals (Sweden)

    Brill Alexander


    Full Text Available Abstract Background The Rel/NF-κB transcription factors have been shown to regulate apoptosis in different cell types, acting as inducers or blockers in a stimuli- and cell type-dependent fashion. One of the Rel/NF-κB subunits, RelA, has been shown to be crucial for normal embryonic development, in which it functions in the embryonic liver as a protector against TNFα-induced physiological apoptosis. This study assesses whether NF-κB may be involved in the embryo's response to teratogens. Fot this, we evaluated how NF-KappaB DNA binding activity in embryonic organs demonstraiting differential sensitivity to a reference teratogen, cyclophosphamide, correlates with dysmorphic events induced by the teratogen at the cellular level (excessive apoptosis and at the organ level (structural anomalies. Results The embryonic brain and liver were used as target organs. We observed that the Cyclophosphamide-induced excessive apoptosis in the brain, followed by the formation of severe craniofacial structural anomalies, was accompanied by suppression of NF-κB DNA-binding activity as well as by a significant and lasting increase in the activity of caspases 3 and 8. However, in the liver, in which cyclophosphamide induced transient apoptosis was not followed by dysmorphogenesis, no suppression of NF-κB DNA-binding activity was registered and the level of active caspases 3 and 8 was significantly lower than in the brain. It has also been observed that both the brain and liver became much more sensitive to the CP-induced teratogenic insult if the embryos were exposed to a combined treatment with the teratogen and sodium salicylate that suppressed NF-κB DNA-binding activity in these organs. Conclusion The results of this study demonstrate that suppression of NF-κB DNA-binding activity in embryos responding to the teratogenic insult may be associated with their decreased resistance to this insult. They also suggest that teratogens may suppress NF-κB DNA

  13. The Whiteley Index-6: An Examination of Measurement Invariance Among Self-Identifying Black, Latino, and White Respondents in Primary Care. (United States)

    Fergus, Thomas A; Kelley, Lance P; Griggs, Jackson O


    Brief measures that are comparable across disparate groups are particularly likely to be useful in primary care settings. Prior research has supported a six-item short form of the Whiteley Index (WI), a commonly used measure of health anxiety, among English-speaking respondents. This study examined the measurement invariance of the WI-6 among Black (n = 183), Latino (n = 173), and White (n = 177) respondents seeking treatment at a U.S. community health center. Results supported a bifactor model of the WI-6 among the composite sample (N = 533), suggesting the presence of a general factor and two domain-specific factors. Results supported the incremental validity of one of the domain-specific factors in accounting for unique variance in somatic symptom severity scores beyond the general factor. Multiple-groups confirmatory factor analysis supported the configural, metric, ands scalar invariance of the bifactor WI-6 model across the three groups of respondents. Results provide support for the measurement invariance of the WI-6 among Black, Latino, and White respondents. The potential use of the WI-6 in primary care, and broader, settings is discussed.


    Directory of Open Access Journals (Sweden)

    Alec H. Medbery


    Full Text Available The remote control of real time derivation of earthquake location and magnitude and the issuance of tsunami and earthquake bulletins was done using off-the-shelf remote control software and hardware. Such remote operation of the West Coast/Alaska Tsunami Warning Center can decrease the time needed to respond to an earthquake by eliminating travel from the duty standers’ home to the tsunami warning center.

  15. On chains of centered valuations

    Directory of Open Access Journals (Sweden)

    Rachid Chibloun


    Full Text Available We study chains of centered valuations of a domain A and chains of centered valuations of A [X1,…,Xn] corresponding to valuations of A. Finally, we make some applications to chains of valuations centered on the same ideal of A [X1,…,Xn] and extending the same valuation of A.


    California State Dept. of Education, Sacramento.


  17. Response of exposed bark and exposed lichen to an urban area

    Energy Technology Data Exchange (ETDEWEB)

    Cruz, A.M.J. [Polytechnic Institute of Coimbra, Oliveira do Hospital (Portugal). Oliveira do Hospital College of Technology and Management; Freitas, M.C.; Canha, N. [URSN, Sacavem (Portugal). Inst. Tecnologico e Nuclear (ITN); Verburg, T.G.; Wolterbeek, H.T. [Technical Univ. of Delft (Netherlands). Dept. of Radiation, Radionuclides and Reactors


    The aim of this study is to understand emission sources of chemical elements using biomonitoring as a tool. The selected lichen and bark were respectively Parmotrema bangii and Criptomeria japonica, sampled in the pollution-free atmosphere of Azores (Sao Miguel island), Portugal, and were exposed in the courtyards of 22 basic schools of Lisbon. The exposure was from January to May 2008 and from June to October 2008 (designated through the text as winter and summer respectively). The chemical element concentrations were determined by INAA. Conductivity of the lichen samples was measured. Factor analysis (MCTTFA) was applied to winter/summer bark/lichen exposed datasets. Arsenic emission sources, soil with anthropogenic contamination, a Se source, traffic, industry, and a sea contribution, were identified. In lichens, a physiological source based on the conductivity values was found. The spatial study showed contribution of sources to specific school positioning. Conductivity values were high in summer in locations as international Lisbon airport and downtown. Lisbon is spatially influenced by marine air mass transportation. It is concluded that one air sampler in Lisbon might be enough to define the emission sources under which they are influenced. (orig.)

  18. Assessing the photoaging process at sun exposed and non-exposed skin using fluorescence lifetime spectroscopy (United States)

    Saito Nogueira, Marcelo; Kurachi, Cristina


    Photoaging is the skin premature aging due to exposure to ultraviolet light, which damage the collagen, elastin and can induce alterations on the skin cells DNA, and, then, it may evolve to precancerous lesions, which are widely investigated by fluorescence spectroscopy and lifetime. The fluorescence spectra and fluorescence lifetime analysis has been presented as a technique of great potential for biological tissue characterization at optical diagnostics. The main targeted fluorophores are NADH (nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide), which have free and bound states, each one with different average lifetimes. The average lifetimes for free and bound NADH and FAD change according to tissue metabolic alterations and may contribute to a non-invasive clinical investigation of injuries such as skin lesions. These lesions and the possible areas where they may develop can be interrogated using fluorescence lifetime spectroscopy taking into account the variability of skin phototypes and the changes related to melanin, collagen and elastin, endogenous fluorophores which have emissions that spectrally overlap to the NADH and FAD emission. The objective of this study is to assess the variation on fluorescence lifetimes of normal skin at sun exposed and non-exposed areas and associate this variation to the photoaging process.

  19. Affective and Cardiovascular Responding to Unpleasant Events from Adolescence to Old Age: Complexity of Events Matters (United States)

    Wrzus, Cornelia; Muller, Viktor; Wagner, Gert G.; Lindenberger, Ulman; Riediger, Michaela


    Two studies investigated the "overpowering hypothesis" as a possible explanation for the currently inconclusive empirical picture on age differences in affective responding to unpleasant events. The overpowering hypothesis predicts that age differences in affective responding are particularly evident in highly resource-demanding situations that…

  20. Responding to Boy Readers: A Closer Look at the Role of the Teacher in Dialogue Journals (United States)

    Werderich, Donna E.


    In this qualitative study, the author examined the ways middle school literacy teachers responded to their boys' dialogue journals. The participants were 3 middle school literacy teachers and 19 middle school boys. The findings of this study indicated that the teachers took 4 roles (teacher as reader, teacher as responder, teacher as facilitator,…

  1. Changes in Blood Pressure and Heart Rate during Fixed-Interval Responding in Squirrel Monkeys (United States)

    DeWeese, Jo


    Episodic and sustained increases in heart rate and mean arterial blood pressure can occur with recurring patterns of schedule-controlled behavior. Most previous studies were conducted under fixed-ratio schedules, which maintained a consistent high rate of responding that alternated with periods of no responding during times when the schedule was…

  2. The effect of English job titles in job advertisements on Dutch respondents

    NARCIS (Netherlands)

    Meurs, F. van; Korzilius, H.P.L.M.; Planken, B.C.; Fairley, S.


    This paper reports on a study that tested the effect on Dutch respondents of using English in job titles. One half of the respondents evaluated five English job titles, and the other half evaluated the equivalent Dutch job titles. The results of the experiment support claims about the effect of Engl

  3. A measure method of the time respond function for gas ionization chamber

    CERN Document Server

    Wang Li; Qing Shang Yu


    In quick scanning radiography system, the time respond speed of array gas ionization chamber effects the image clarity directly. The author presents a measure method of the time respond function for gas ionization chamber. The image clarity will be improved by inverse convoluting the image data

  4. The Role of the Nucleus Accumbens in Knowing when to Respond (United States)

    Singh, Teghpal; McDannald, Michael A.; Takahashi, Yuji K.; Haney, Richard Z.; Cooch, Nisha K.; Lucantonio, Federica; Schoenbaum, Geoffrey


    While knowing what to expect is important, it is equally important to know when to expect it and to respond accordingly. This is apparent even in simple Pavlovian training situations in which animals learn to respond more strongly closer to reward delivery. Here we report that the nucleus accumbens core, an area well-positioned to represent…

  5. Think or Click? Student Preference for Overt vs. Covert Responding in Web-Based Instruction. (United States)

    Haggas, Amy M.; Hantula, Donald A.


    Investigates undergraduate student preference for overt vs. covert responding in a Web-based tutorial using a within-subject design. Explains covert question format, which requires passive thinking, and overt format, which requires active responding; and discusses results which show a preference for the overt format. (Author/LRW)

  6. Dimensions of Self-Identification among Multiracial and Multiethnic Respondents in Survey Interviews. (United States)

    Johnson, Timothy P.; Jobe, Jared B.; O'Rourke, Diane; Sudman, Seymour; Warnecke, Richard B.; Chavez, Noel; Chapa-Resendez, Gloria; Golden, Patricia


    Findings from a study involving 69 multiracial and multiethnic women show that respondents' racial identification varies considerably across question formats and that persons of mixed heritage prefer a racial identification question that provides them the opportunity to acknowledge their multiracial backgrounds. Many respondents also wanted to…

  7. Cortisol Reactivity and Regulation Associated with Shame Responding in Early Childhood (United States)

    Mills, Rosemary S. L.; Imm, Gorette P.; Walling, Bobbi R.; Weiler, Hope A.


    The purpose of this study was to characterize cortisol response and regulation associated with shame responding in early childhood and to examine how general the relation between shame and cortisol is. It was predicted that children responding to task failure with shame would show a larger and more prolonged cortisol response than other children.…

  8. Responding to Literature through Storytelling, Artifacts and Multigenre Writing Practices: Explorations of Cultures and Self (United States)

    Varga-Dobai, Kinga


    This manuscript describes how innovative literacy practices such as multigenre writing and artifactual critical literacy have been used to tap into pre-service teachers' cultural identities while responding to literature. In the process of responding to literature, personal experience is crucial; therefore, in this study, I focused on the…

  9. Effects of Antecedent Variables on Disruptive Behavior and Accurate Responding in Young Children in Outpatient Settings (United States)

    Boelter, Eric W.; Wacker, David P.; Call, Nathan A.; Ringdahl, Joel E.; Kopelman, Todd; Gardner, Andrew W.


    The effects of manipulations of task variables on inaccurate responding and disruption were investigated with 3 children who engaged in noncompliance. With 2 children in an outpatient clinic, task directives were first manipulated to identify directives that guided accurate responding; then, additional dimensions of the task were manipulated to…

  10. The Power of Cross-Disciplinary Teams for Developing First Responder Training in TBI (United States)

    Shackelford, Jo L.; Cappiccie, Amy


    Misunderstanding of the symptoms of traumatic brain injury (TBI) often leaves first responders ill-equipped to handle encounters involving subjects with brain injury. This paper details a cross-disciplinary project to develop and disseminate a training curriculum designed to increase first responders' knowledge of and skills with TBI survivors.…


    Energy Technology Data Exchange (ETDEWEB)



    Computational Science is an integral component of Brookhaven's multi science mission, and is a reflection of the increased role of computation across all of science. Brookhaven currently has major efforts in data storage and analysis for the Relativistic Heavy Ion Collider (RHIC) and the ATLAS detector at CERN, and in quantum chromodynamics. The Laboratory is host for the QCDOC machines (quantum chromodynamics on a chip), 10 teraflop/s computers which boast 12,288 processors each. There are two here, one for the Riken/BNL Research Center and the other supported by DOE for the US Lattice Gauge Community and other scientific users. A 100 teraflop/s supercomputer will be installed at Brookhaven in the coming year, managed jointly by Brookhaven and Stony Brook, and funded by a grant from New York State. This machine will be used for computational science across Brookhaven's entire research program, and also by researchers at Stony Brook and across New York State. With Stony Brook, Brookhaven has formed the New York Center for Computational Science (NYCCS) as a focal point for interdisciplinary computational science, which is closely linked to Brookhaven's Computational Science Center (CSC). The CSC has established a strong program in computational science, with an emphasis on nanoscale electronic structure and molecular dynamics, accelerator design, computational fluid dynamics, medical imaging, parallel computing and numerical algorithms. We have been an active participant in DOES SciDAC program (Scientific Discovery through Advanced Computing). We are also planning a major expansion in computational biology in keeping with Laboratory initiatives. Additional laboratory initiatives with a dependence on a high level of computation include the development of hydrodynamics models for the interpretation of RHIC data, computational models for the atmospheric transport of aerosols, and models for combustion and for energy utilization. The CSC was formed to

  12. Ghosts of thermal past: reef fish exposed to historic high temperatures have heightened stress response to further stressors (United States)

    Mills, S. C.; Beldade, R.; Chabanet, P.; Bigot, L.; O'Donnell, J. L.; Bernardi, G.


    Individual exposure to stressors can induce changes in physiological stress responses through modulation of the hypothalamic-pituitary-interrenal (HPI) axis. Despite theoretical predictions, little is known about how individuals will respond to unpredictable short-lived stressors, such as thermal events. We examine the primary neuroendocrine response of coral reef fish populations from the Îles Eparses rarely exposed to anthropogenic stress, but that experienced different thermal histories. Skunk anemonefish, Amphiprion akallopisos, showed different cortisol responses to a generic stressor between islands, but not along a latitudinal gradient. Those populations previously exposed to higher maximum temperatures showed greater responses of their HPI axis. Archive data reveal thermal stressor events occur every 1.92-6 yr, suggesting that modifications to the HPI axis could be adaptive. Our results highlight the potential for adaptation of the HPI axis in coral reef fish in response to a climate-induced thermal stressor.

  13. Citizen centered design

    Directory of Open Access Journals (Sweden)

    Ingrid Mulder


    Full Text Available Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with bottom-up social innovation to reach meaningful design. The biggest challenge is indeed to embrace a new collaborative attitude, a participatory approach, and to have the proper infrastructure that supports this social fabric. Participatory design and transition management are future-oriented, address people and institutions. Only through understanding people in context and the corresponding dynamics, one is able to design for liveable and sustainable urban environments, embracing the human scale.

  14. Mi Pueblo Food Center

    Directory of Open Access Journals (Sweden)

    Alexis A. Babb


    Full Text Available This case describes a current growth opportunity for Mi Pueblo Food Center, a Hispanic grocery chain with locations throughout the Bay Area, California. The CEO of Mi Pueblo is contemplating opening a new store location in East Palo Alto, CA, which has been without a local, full-service grocery store for over 20 years. Case objectives are for students to develop an understanding of how the grocery industry operates, the risks and opportunities associated with opening a new grocery store location, and the impact on social, environmental, and economic sustainability. The SWOT (Strengths, Weaknesses, Opportunities, Threats framework is used to analyze whether or not it is feasible for Mi Pueblo to open a new location in East Palo Alto. This case may be used with students in graduate and advanced undergraduate courses.

  15. Supernova Science Center

    Energy Technology Data Exchange (ETDEWEB)

    S. E. Woosley


    The Supernova Science Center (SNSC) was founded in 2001 to carry out theoretical and computational research leading to a better understanding of supernovae and related transients. The SNSC, a four-institutional collaboration, included scientists from LANL, LLNL, the University of Arizona (UA), and the University of California at Santa Cruz (UCSC). Intitially, the SNSC was funded for three years of operation, but in 2004 an opportunity was provided to submit a renewal proposal for two years. That proposal was funded and subsequently, at UCSC, a one year no-cost extension was granted. The total operational time of the SNSC was thus July 15, 2001 - July 15, 2007. This document summarizes the research and findings of the SNSC and provides a cummulative publication list.

  16. Industrial Assessment Center Program

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Dereje Agonafer


    The work described in this report was performed under the direction of the Industrial Assessment Center (IAC) at University of Texas at Arlington. The IAC at The University of Texas at Arlington is managed by Rutgers University under agreement with the United States Department of Energy Office of Industrial Technology, which financially supports the program. The objective of the IAC is to identify, evaluate, and recommend, through analysis of an industrial plant’s operations, opportunities to conserve energy and prevent pollution, thereby reducing the associated costs. IAC team members visit and survey the plant. Based upon observations made in the plant, preventive/corrective actions are recommended. At all times we try to offer specific and quantitative recommendations of cost savings, energy conservation, and pollution prevention to the plants we serve.

  17. Concurrent engineering research center (United States)

    Callahan, John R.


    The projects undertaken by The Concurrent Engineering Research Center (CERC) at West Virginia University are reported and summarized. CERC's participation in the Department of Defense's Defense Advanced Research Project relating to technology needed to improve the product development process is described, particularly in the area of advanced weapon systems. The efforts committed to improving collaboration among the diverse and distributed health care providers are reported, along with the research activities for NASA in Independent Software Verification and Validation. CERC also takes part in the electronic respirator certification initiated by The National Institute for Occupational Safety and Health, as well as in the efforts to find a solution to the problem of producing environment-friendly end-products for product developers worldwide. The 3M Fiber Metal Matrix Composite Model Factory Program is discussed. CERC technologies, facilities,and personnel-related issues are described, along with its library and technical services and recent publications.

  18. The Center is Everywhere

    CERN Document Server

    Weinberg, David H


    "The Center is Everywhere" is a sculpture by Josiah McElheny, currently (through October 14, 2012) on exhibit at the Institute of Contemporary Art, Boston. The sculpture is based on data from the Sloan Digital Sky Survey (SDSS), using hundreds of glass crystals and lamps suspended from brass rods to represent the three-dimensional structure mapped by the SDSS through one of its 2000+ spectroscopic plugplates. This article describes the scientific ideas behind this sculpture, emphasizing the principle of the statistical homogeneity of cosmic structure in the presence of local complexity. The title of the sculpture is inspired by the work of the French revolutionary Louis Auguste Blanqui, whose 1872 book "Eternity Through The Stars: An Astronomical Hypothesis" was the first to raise the spectre of the infinite replicas expected in an infinite, statistically homogeneous universe. Puzzles of infinities, probabilities, and replicas continue to haunt modern fiction and contemporary discussions of inflationary cosmo...

  19. Regional Warning Center Sweden (United States)

    Lundstedt, Henrik

    RWC-Sweden is operated by the Lund division of the Swedish Institute of Space Physics located at IDEON, a Science Research Technology Park. The Institute of Technology of Lund and Lund University are just adjacent to IDEON. This creates a lot of synergy effects. Copenhagen, with the Danish National Space Center DNSC), and Atmosphere Space Research Division of Danish Meteorological Institute (DMI), is 45 min away via the bridge. The new LOIS Space Centre is located two hours away by car, north of Lund and just outside V¨xj¨. The IRF Lund a o division is aiming at becoming a "Solar and Space Weather Center". We focus on solar magnetic activity, its influence on climate and on space weather effects such the effect of geomagnetically induced currents (GIC). Basic research: A PostDoc position on "Solar Magnetic Activity: Topology and Predictions has recently been created. Research is carried on to improve predictions of solar magnetic activity. Preparations for using upcoming SDO vector magnetic fields are ongoing. Predictions: RWC-Sweden offers real-time forecasts of space weather and space weather effects based on neural networks. We participated in the NASA/NOAA Cycle 24 Prediction Panel. We have also participated in several ESA/EU solar-climate projects New observation facilities: Distributed, wide-area radio facility (LOIS) for solar (and other space physics) observations and a guest prof: Radio facility about 200 km distant, outside V¨xj¨ (Sm˚ a o aland), in Ronneby (Blekinge) and Lund (Sk˚ ane) is planned to be used for tracking of CMEs and basic solar physics studies of the corona. The LOIS station outside V¨xj¨ has a o been up and running for the past three years. Bo Thidé has joined the Lund division e as a guest prof. A new magnetometer at Risinge LOIS station has been installed an calibrated and expected to be operational in March, 2008.

  20. 9 CFR 78.32 - Brucellosis exposed swine. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Brucellosis exposed swine. 78.32... AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Swine Because of Brucellosis § 78.32 Brucellosis exposed swine....

  1. 9 CFR 78.23 - Brucellosis exposed bison. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Brucellosis exposed bison. 78.23... AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Bison Because of Brucellosis § 78.23 Brucellosis exposed...

  2. 9 CFR 78.8 - Brucellosis exposed cattle. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Brucellosis exposed cattle. 78.8... AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BRUCELLOSIS Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.8 Brucellosis exposed...

  3. The Psychobiology of Children Exposed to Marital Violence (United States)

    Saltzman, Kasey M.; Holden, George W.; Holahan, Charles J.


    We examined the psychological and physiological functioning of a community sample of children exposed to marital violence, comparing them to a clinical comparison group without marital violence exposure. Results replicated past findings of elevated levels of trauma symptomatology in this population. Further, children exposed to marital violence…

  4. Animal Cruelty by Children Exposed to Domestic Violence (United States)

    Currie, Cheryl L.


    Objective: The first objective of this study was to determine if children exposed to domestic violence were significantly more likely to be cruel to animals than children not exposed to violence. The second was to determine if there were significant age and gender differences between children who were and were not cruel to animals. Method: A…

  5. 46 CFR 177.960 - Guards for exposed hazards. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Guards for exposed hazards. 177.960 Section 177.960 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Rails and Guards § 177.960 Guards for exposed hazards. An...

  6. 46 CFR 28.215 - Guards for exposed hazards. (United States)


    ... 46 Shipping 1 2010-10-01 2010-10-01 false Guards for exposed hazards. 28.215 Section 28.215 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY UNINSPECTED VESSELS REQUIREMENTS FOR COMMERCIAL....215 Guards for exposed hazards. (a) Each space on board a vessel must meet the requirements of...

  7. Upgrade and Design of Coastal Structures Exposed to Climate Changes

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen Quvang Harck

    This thesis “Upgrade and Design of Coastal Structures Exposed to Climate Changes” evaluates the performance of existing types of structures when exposed to climate changes. This includes also the potential of using cost‐sharing multipurpose structures for protection against the effects of future...

  8. Renormings concerning exposed points and non-smoothness

    Institute of Scientific and Technical Information of China (English)

    GARCíA-PACHECO; Francisco; Javier


    Intuitively, non-smooth points might look like exposed points. However, in this paper we show that real Banach spaces having dimension greater than or equal to three can be equivalently renormed to obtain non-smooth points which are also non-exposed.

  9. Assimilation of zinc by Porcellio scaber (Isopoda, Crustacea) exposed to zinc

    Energy Technology Data Exchange (ETDEWEB)

    Bibic, A.; Drobne, D.; Strus, J. [Univ. of Ljubijana (Slovenia)


    The ability of terrestrial isopods to accumulate high amounts of metals, to survive in industrially polluted areas and respond to environmental contaminants in a dose-dependent manner makes them one of the most favorite experimental organisms for terrestrial ecotoxicology. Understanding metal uptake, assimilation and loss by these animals is important to explain how they cope with polluted environments. Metal uptake depends on the rate of food consumption, on metal availability in the food, on the pH inside the gut and some other factors. Isopods respond to high metal concentrations in the food in different ways and try to avoid the negative effects of metal poisoning. Zinc is one of the metals present in high concentrations in industrially polluted areas. Zinc poisoning may be avoided by the regulation of the consumption rate, by behavioral response, by storing metals in the hepatopancreas as insoluble granules, and by fecal, and possibly urinary, excretion. Zinc in organisms is a constituent of more than 200 metalloenzymes and other metabolic compounds and assures stability of biological molecules and structures. High Zn levels in food cause a reduction of feeding rate, affect growth and reproduction, cause changes in the structure of the digestive glands and influence the duration of the molting cycle. The present study investigated zinc assimilation by Porcellio scaber exposed to leaves contaminated with radioactively labeled zinc at five different concentrations. 17 refs., 2 figs., 2 tabs.

  10. Human Serum-Specific Activation of Alternative Sigma Factors, the Stress Responders in Aggregatibacter actinomycetemcomitans (United States)

    Tang-Siegel, Gaoyan; Bumgarner, Roger; Ruiz, Teresa; Kittichotirat, Weerayuth; Chen, Weizhen; Chen, Casey


    Aggregatibacter actinomycetemcomitans, a known pathogen causing periodontal disease and infective endocarditis, is a survivor in the periodontal pocket and blood stream; both environments contain serum as a nutrient source. To screen for unknown virulence factors associated with this microorganism, A. actinomycetemcomitans was grown in serum-based media to simulate its in vivo environment. Different strains of A. actinomycetemcomitans showed distinct growth phenotypes only in the presence of human serum, and they were grouped into high- and low-responder groups. High-responders comprised mainly serotype c strains, and showed an unusual growth phenomenon, featuring a second, rapid increase in turbidity after 9-h incubation that reached a final optical density 2- to 7-fold higher than low-responders. Upon further investigation, the second increase in turbidity was not caused by cell multiplication, but by cell death. Whole transcriptomic analysis via RNA-seq identified 35 genes that were up-regulated by human serum, but not horse serum, in high-responders but not in low-responders, including prominently an alternative sigma factor rpoE (σE). A lacZ reporter construct driven by the 132-bp rpoE promoter sequence of A. actinomycetemcomitans responded dramatically to human serum within 90 min of incubation only when the construct was carried by a high responder strain. The rpoE promoter is 100% identical among high- and low-responder strains. Proteomic investigation showed potential interactions between human serum protein, e.g. apolipoprotein A1 (ApoA1) and A. actinomycetemcomitans. The data clearly indicated a different activation process for rpoE in high- versus low-responder strains. This differential human serum-specific activation of rpoE, a putative extra-cytoplasmic stress responder and global regulator, suggests distinct in vivo adaptations among different strains of A. actinomycetemcomitans. PMID:27490177

  11. Assessment of community healthcare providers ability and willingness to respond to emergencies resulting from bioterrorist attacks

    Directory of Open Access Journals (Sweden)

    Crane Jeffery


    Full Text Available Introduction: Previous findings have demonstrated that preparedness and planning within the public health system are inadequately developed to respond to an act of biological or chemical terrorism. Methods:This investigation used Internet-based surveys to assess the level of preparedness (PL and willingness to respond (WTR to a bioterrorism attack, and identify factors that predict PL and WTR among Florida community healthcare providers. Invitations were sent to 22,800 healthcare providers in Florida, which resulted in 2,279 respondents. Results: Respondents included physicians (n=604, nurses (n=1,152, and pharmacists (n=486. The results indicated that only 32% of Florida healthcare providers were competent and willing to respond to a bioterrorism attack, 82.7% of providers were willing to respond in their local community, and 53.6% within the State. Respondents were more competent in administrative skills than clinical knowledge (62.8% vs. 45%. Areas in which respondents had the highest competency were the initiation of treatment and recognition of their clinical and administrative roles. Areas in which respondents showed the lowest competency were the ability to identify cases and the ability to communicate risk to others. About 55% of the subjects had previous bioterrorism training and 31.5% had conducted emergency drills. Gender, race, previous training and drills, perceived threats of bioterrorism attack, perceived benefits of training and drills, and feeling prepared were all predictors of overall preparedness. Conclusions: The findings suggest that only one-third of Florida community healthcare providers were prepared for a bioterrorism attack, which is an insufficient response rate to effectively respond to a bioterrorism incident.

  12. Neonatal extracorporeal membrane oxygenation devices, techniques and team roles: 2011 survey results of the United States' Extracorporeal Life Support Organization centers. (United States)

    Lawson, Scott; Ellis, Cory; Butler, Katie; McRobb, Craig; Mejak, Brian


    In early 2011, surveys of active Extracorporeal Life Support Organization (ELSO) centers within the United States were conducted by electronic mail regarding neonatal Extracorporeal Membrane Oxygenation (ECMO) equipment and professional staff. Seventy-four of 111 (67%) U.S. centers listed in the ELSO directory as neonatal centers responded to the survey. Of the responding centers, 53% routinely used roller pumps for neonatal ECMO, 15% reported using centrifugal pumps and 32% reported using a combination of both. Of the centers using centrifugal pumps, 51% reported that they do not use a compliance bladder in the circuit. The majority (95%) of roller pump users reported using a compliance bladder and 97% reported using Tygon" S-97-E tubing in the raceway of their ECMO circuits. Silicone membrane oxygenators were reportedly used by 25% of the respondents, 5% reported using micro-porous hollow fiber oxygenators (MPHF), 70% reported using polymethylpentene (PMP) hollow fiber oxygenators and 5% reported using a combination of the different types. Some form of in-line blood monitoring was used by 88% of the responding centers and 63% of responding centers reported using a circuit surface coating. Anticoagulation monitoring via the activated clotting time (ACT) was reported by 100% of the reporting centers. The use of extracorporeal cardiopulmonary resuscitation (ECPR) was reported by 53% of the responding centers with 82% of those centers using a crystalloid primed circuit to initiate ECPR. A cooling protocol was used by 77% of the centers which have an ECPR program. When these data are compared with surveys from 2002 and 2008 it shows that the use of silicone membrane oxygenators continues to decline, the use of centrifugal pumps continues to increase and ECMO personnel continues to be comprised of multidisciplinary groups of dedicated allied health care professionals.

  13. Self-reported hearing performance in workers exposed to solvents

    Directory of Open Access Journals (Sweden)

    Adrian Fuente


    Full Text Available OBJECTIVE: To compare hearing performance relating to the peripheral and central auditory system between solvent-exposed and non-exposed workers. METHODS: Forty-eight workers exposed to a mixture of solvents and 48 non-exposed control subjects of matched age, gender and educational level were selected to participate in the study. The evaluation procedures included: pure-tone audiometry (500 - 8,000 Hz, to investigate the peripheral auditory system; the Random Gap Detection test, to assess the central auditory system; and the Amsterdam Inventory for Auditory Disability and Handicap, to investigate subjects' self-reported hearing performance in daily-life activities. A Student t test and analyses of covariance (ANCOVA were computed to determine possible significant differences between solvent-exposed and non-exposed subjects for the hearing level, Random Gap Detection test and Amsterdam Inventory for Auditory Disability and Handicap. Pearson correlations among the three measures were also calculated. RESULTS: Solvent-exposed subjects exhibited significantly poorer hearing thresholds for the right ear than non-exposed subjects. Also, solvent-exposed subjects exhibited poorer results for the Random Gap Detection test and self-reported poorer listening performance than non-exposed subjects. Results of the Amsterdam Inventory for Auditory Disability and Handicap were significantly correlated with the binaural average of subject pure-tone thresholds and Random Gap Detection test performance. CONCLUSIONS: Solvent exposure is associated with poorer hearing performance in daily life activities that relate to the function of the peripheral and central auditory system.

  14. Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow. (United States)

    Whyte, Claire S; Swieringa, Frauke; Mastenbroek, Tom G; Lionikiene, Ausra S; Lancé, Marcus D; van der Meijden, Paola E J; Heemskerk, Johan W M; Mutch, Nicola J


    The interaction of plasminogen with platelets and their localization during thrombus formation and fibrinolysis under flow are not defined. Using a novel model of whole blood thrombi, formed under flow, we examine dose-dependent fibrinolysis using fluorescence microscopy. Fibrinolysis was dependent upon flow and the balance between fibrin formation and plasminogen activation, with tissue plasminogen activator-mediated lysis being more efficient than urokinase plasminogen activator-mediated lysis. Fluorescently labeled plasminogen radiates from platelet aggregates at the base of thrombi, primarily in association with fibrin. Hirudin attenuates, but does not abolish plasminogen binding, denoting the importance of fibrin. Flow cytometry revealed that stimulation of platelets with thrombin/convulxin significantly increased the plasminogen signal associated with phosphatidylserine (PS)-exposing platelets. Binding was attenuated by tirofiban and Gly-Pro-Arg-Pro amide, confirming a role for fibrin in amplifying plasminogen binding to PS-exposing platelets. Confocal microscopy revealed direct binding of plasminogen and fibrinogen to different platelet subpopulations. Binding of plasminogen and fibrinogen co-localized with PAC-1 in the center of spread platelets. In contrast, PS-exposing platelets were PAC-1 negative, and bound plasminogen and fibrinogen in a protruding "cap." These data show that different subpopulations of platelets harbor plasminogen by diverse mechanisms and provide an essential scaffold for the accumulation of fibrinolytic proteins that mediate fibrinolysis under flow.

  15. Tsunami-exposed tourist survivors: signs of recovery in a 3-year perspective. (United States)

    Johannesson, Kerstin Bergh; Lundin, Tom; Fröjd, Thomas; Hultman, Christina M; Michel, Per-Olof


    Long-term follow-up after disaster exposure indicates increased rates of psychological distress. However, trajectories and rates of recovery in large samples of disaster-exposed survivors are largely lacking. A group of 3457 Swedish survivors temporarily on vacation in Southeast Asia during the 2004 tsunami were assessed by postal questionnaire at 14 months and 3 years after the tsunami regarding post-traumatic stress reactions (IES-R) and general mental health (GHQ-12). There was a general pattern of resilience and recovery 3 years postdisaster. Severe exposure and traumatic bereavement were associated with increased post-traumatic stress reactions and heightened risk for impaired mental health. The rate of recovery was lower among respondents exposed to life threat and among bereaved. Severe trauma exposure and bereavement seem to have considerable long-term impact on psychological distress and appear to slow down the recovery process. Readiness among health agencies for identification of symptoms and provision of interventions might facilitate optimal recovery.

  16. Exposing SAMOS Data and Vocabularies within the Semantic Web (United States)

    Dockery, Nkemdirim; Elya, Jocelyn; Smith, Shawn


    As part of the Ocean Data Interoperability Platform (ODIP), we at the Center for Ocean-Atmospheric Prediction Studies (COAPS) will present the development process for the exposure of quality-controlled data and core vocabularies managed by the Shipboard Automated Meteorological Oceanographic System (SAMOS) initiative using Semantic Web technologies. Participants in the SAMOS initiative collect continuous navigational (position, course, heading, speed), meteorological (winds, pressure, temperature, humidity, radiation), and near-surface oceanographic (sea temperature, salinity) parameters while at sea. One-minute interval observations are packaged and transmitted back to COAPS via daily emails, where they undergo standardized formatting and quality control. The authors will present methods used to expose these daily datasets. The Semantic Web, a vision of the World Wide Web Consortium, focuses on extending the principles of the web from connecting documents to connecting data. The creation of a web of Linked Data that can be used across different applications in a machine-readable way is the ultimate goal. The Resource Description Framework (RDF) is the standard language and format used in the Semantic Web. RDF pages may be queried using the SPARQL Protocol and RDF Query Language (SPARQL). The authors will showcase the development of RDF resources that map SAMOS vocabularies to internationally served vocabularies such as those found in the Natural Environment Research Council (NERC) Vocabulary Server. Each individual SAMOS vocabulary term (data parameter and quality control flag) will be described in an RDF resource page. These RDF resources will define each SAMOS vocabulary term and provide a link to the mapped vocabulary term (or multiple terms) served externally. Along with enhanced retrieval by parameter, time, and location, we will be able to add additional parameters with the confidence that they follow an international standard. The production of RDF

  17. College Counseling Today: Contemporary Students and How Counseling Centers Meet Their Needs (United States)

    Brunner, Jon L.; Wallace, David L.; Reymann, Linda S.; Sellers, Jes-James; McCabe, Adam G.


    There is evidence that today's college and university students are struggling with emotional and behavioral health problems at higher rates than in past generations. This article explores the various ways, utilizing a range of models, that college and university counseling centers have mobilized to respond to these challenges. We examine…

  18. Air Corrosivity in U.S. Outdoor-Air-Cooled Data Centers is Similar to That in Conventional Data Centers

    Energy Technology Data Exchange (ETDEWEB)

    Coles, Henry C.; Han, Taewon; Price, Phillip N.; Gadgil, Ashok J.; Tschudi, William F.


    There is a concern that environmental-contamination caused corrosion may negatively affect Information Technology (IT) equipment reliability. Nineteen data centers in the United States and two in India were evaluated using Corrosion Classification Coupons (CCC) to assess environmental air quality as it may relate IT equipment reliability. The data centers were of two basic types: closed and outside-air cooled. A closed data center provides cool air to the IT equipment using air conditioning in which only a small percent age of the recirculation air is make-up air continuously supplied from outside to meet human health requirements. An outside-air cooled data center uses outside air directly as the primary source for IT equipment cooling. Corrosion measuring coupons containing copper and silver metal strips were placed in both closed and outside-air cooled data centers. The coupons were placed at each data center (closed and outside-air cooled types) with the location categorized into three groups: (1) Outside - coupons sheltered, located near or at the supply air inlet, but located before any filtering, (2) Supply - starting just after initial air filtering continuing inside the plenums and ducts feeding the data center rooms, and (3) Inside located inside the data center rooms near the IT equipment. Each coupon was exposed for thirty days and then sent to a laboratory for a corrosion rate measurement analysis. The goal of this research was to investigate whether gaseous contamination is a concern for U.S. data center operators as it relates to the reliability of IT equipment. More specifically, should there be an increased concern if outside air for IT equipment cooling is used To begin to answer this question limited exploratory measurements of corrosion rates in operating data centers in various locations were undertaken. This study sought to answer the following questions: (1) What is the precision of the measurements (2) What are the approximate statistical

  19. The mental health of populations directly and indirectly exposed to violent conflict in Indonesia

    Directory of Open Access Journals (Sweden)

    Klungsøyr Ole


    Full Text Available Abstract Background Large disasters affect people who live both near and far from the areas in which they occur. The mental health impact is expected to be similar to a ripple effect, where the risk of mental health consequences generally decreases with increasing distance from the disaster center. However, we have not been able to identify studies of the ripple effect of man-made disaster on mental health in low-income countries. Objectives The objective was to examine the hypothesis of a ripple effect on the mental health consequences in populations exposed to man-made disasters in a developing country context, through a comparison of two different populations living in different proximities from the center of disaster in Mollucas. Methods Cross-sectional longitudinal data were collected from 510 Internally Displaced Persons (IDPs living in Ambon, who were directly exposed to the violence, and non-IDPs living in remote villages in Mollucas, Indonesia, who had never been directly exposed to violence in Mollucas. Data were collected during home visits and statistical comparisons were conducted by using chi square tests, t-test and logistic regression. Results There was significantly more psychological distress "caseness" in IDPs than non-IDPs. The mental health consequences of the violent conflict in Ambon supported the ripple effect hypothesis as displacement status appears to be a strong risk factor for distress, both as a main effect and interaction effect. Significantly higher percentages of IDPs experienced traumatic events than non-IDPs in all six event types reported. Conclusions This study indicates that the conflict had an impact on mental health and economic conditions far beyond the area where the actual violent events took place, in a diminishing pattern in line with the hypothesis of a ripple effect.

  20. Speech Act of Responding to Rudeness: A Case Study of Malaysian University Students

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    Maryam Farnia


    Full Text Available Politeness conventions vary across cultures and so is impoliteness and rudeness. In some cases, what is considered rude in one culture or a society is not necessarily rude or impolite in another. This cannot be explained unless more studies on the use of language functions in a specific culture are conducted. The aim of this paper is to investigate Malaysians university students’ realization of responding to rudeness. For this purpose, 51 Malaysian university students at Universiti Sains Malaysia took part in this research. The respondents completed a Discourse Completion Task consisting of six situations in which they had to respond to an offensive or a rude language directed toward them. The findings were then analyzed using Beebe and Waring’s (2005 a coding scheme of responding rudeness to examine the type and use of strategies in responding to rudeness. Moreover, a post-structured interview was conducted to explore the respondents’ perception of politeness, cognition and language of thought (i.e. the language they think in their mind to produce response in the moment in responding to rudeness. The results showed that participants employ different strategies with variations in contextual variables (i.e. social distance and social status in their responses. The comparison of participants' production and perception in responding to rudeness provided significant results. It is hoped that the analysis of Malaysian university students’ responding to rudeness could add to the body of knowledge in pragmatics and speech act studies in general and to our understanding of Malays university students’ realization in responding to rudeness in particular.