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  1. Cellulitis

    Science.gov (United States)

    ... in the skin. Cellulitis is sometimes accompanied by fever, chills, and general fatigue. If the infection is left ... Cellulitis may be accompanied by swollen lymph nodes, fever, chills, and fatigue. Self-Care Guidelines If you think ...

  2. Diabetes mellitus und endotheliale Dysfunktion

    Directory of Open Access Journals (Sweden)

    Tripolt N

    2010-01-01

    Full Text Available Diabetes mellitus Typ 2 betrifft heute bereits ca. 300 Millionen Menschen weltweit und die Prognosen für die nächsten Jahre sagen noch einen deutlichen Anstieg voraus. Das Risiko für kardiovaskuläre Ereignisse ist bei Typ-2-Diabetikern deutlich gesteigert und stellt somit die Haupttodesursache in diesem Patientenkollektiv dar. Die endotheliale Dysfunktion ist eine frühe Stufe auf dem Weg zum atherothrombotischen Ereignis und ein potenziell reversibler Zustand. Dieser Artikel soll einen Überblick über die Pathogenese, die Möglichkeiten der Messung sowie die therapeutischen Optionen zur Verbesserung der Endothelfunktion bei Diabetikern geben.

  3. Modifications mécaniques et biologiques induites dans des cellules en culture par application locale d'une force contrôlée

    OpenAIRE

    Icard Arcizet, Delphine

    2007-01-01

    Les propriétés mécaniques des cellules adhérentes ont une importance capitale pour l'ensemble de leurs fonctions : division, migration, différenciation, etc. De plus, on sait désormais qu'elles sont très sensibles aux caractéristiques mécaniques de leur substrat, auquel elles sont ancrées par l'intermédiaire des intégrines. Ces récepteurs transmembranaires lient indirectement le cytosquelette d'actine intracellulaire aux protéines de la matrice extracellulaire.Nous avons conçu un dispositif d...

  4. M(E)CANISMES MOL(E)CULAIRES IMPLIQU(E)S DANS L'ALT(E)RATION DU PH(E)NOTYPE DES CELLULES (E)PITHELIAL(E)S TUBULAIRES PAR LES CALPA(I)NES EXTRACELLULAIRES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wen-hui; Joelle Perez; Laurent Baud

    2008-01-01

    Objectif Rechercher les mécanismes moléculaires par lesquels des calpaines extracellulaires af-fectent l'adhérence et la mobilité des cellules épithéliales HK-2 dérivées du tubule proximal humain. Méthodes Western blot pour détecter le clivage des chaines α des intégrines; dosage radioimmunologique pour mesurer l' AMP cyclique intracellulaire; fluorescence-activated cell sorting (FACS) pour tester l' apoptose cellulaire. La morpholo-gie des cellules HK-2 a été observée et photographiée. Résultats (1) L ' exposition des cellules HK-2 à la calpaine μ n'a pas entrainé de clivage des chaines o3 et αV des intégrines; (2)l' exposition des cellules HK-2 à la calpaine μ entrainait une augmentation progressive de l' accumulation intracellulaire d' AMP cyclique (P<0.05) qui était associée une résistance cellulaire à l'apoptose(P <0. 05 ) ; (3)l'addition d'un inhibiteur pharmacologique de la protéine kinase A(PKA) prévenait totalement les modifications d'adhérence et de mobilité cellulaires induites par calpaine μ Conclusion Les calpaines externalisées peuvent modifier l' adherence et la mobilité cellulaires via un mécanisme qui implique l'accumulation d' AMP cyclique et l' activation de la PKA. Par ces mécanismes, les calpaines externalisées pourraient jouer un role dans l'induction de la réparation au cours de l'insuffucance rénale aiguё.

  5. Reprogrammation épigénétique des cellules hôtes par Legionella pneumophila

    OpenAIRE

    Rolando, Monica; Rusniok, Christophe; Margueron, Raphael; Buchrieser, Carmen

    2013-01-01

    International audience Legionella pneumophila est un bacille à Gram négatif à l'origine d'une infection pulmonaire grave appelée légionellose (ou maladie du légionnaire) [11]. Les légionelles sont des bactéries vivant en milieu aquatique et affectionnant particulièrement les eaux tièdes. Ce sont des bactéries intracellulaires facultatives qui colonisent habituellement les amibes, protozoaires qui prolifèrent dans l'eau, mais elles sont également capables d'infecter l'homme par le biais d'a...

  6. Influence de revetements bioactifs sur les cellules endotheliales: Vers des protheses vasculaires non thrombotiques

    Science.gov (United States)

    Fadlallah, Hicham

    Developing vascular prostheses of small diameter to replace vessels closed by atherosclerosis remains a challenge because of the risk of thrombosis. Seeding of endothelial cells, which have antithrombogenic properties, is a promising solution, but we must create surfaces which promote their adhesion and retention to resist shear stresses created by the blood flow on the surface. This master's project aimed at investigating the effect of a plasma polymerized coating rich in primary amines (called LP), with or without elements of the extracellular matrix (Fibronectin (FN) or chondroitin sulphate (CS)) on the endothelial cells and hemocompatibility of polyethylene terephthalate (PET). The adhesion, growth and retention of human umbilical vein endothelial cells (HUVECs) on PET and LP, in the presence and absence of FN or CS, have been studied. In addition, platelet adhesion on different surfaces was evaluated by a perfusion test with whole blood, platelets being previously labeled with rhodamine. Finally a double fluorescent labeling (using Cellview Maroon to mark the HUVECs and CD61 antibody for platelets) was developed to study the retention of endothelial cells, under blood flow and verify their non thrombogenic character. The results obtained show that both the LP coating and the adsorbed FN, strongly increase both the cellular adhesion and growth on PET; however they have no additional effect when the two are combined. They also augment cellular retention to surface, but this remains incomplete. Moreover we observed that the plasma coating (LP) greatly increases the thrombogenicity of the surface, with strong platelet adhesion and activation. This thrombogenicity is extremely reduced when endothelial cells cover the surface, but cell loss under the effect of shear produced by the perfusion creates significant areas of platelet adhesion. The grafting of CS on LP also permits good HUVECs adhesion, growth and retention under shear stress on HUVEC, with no difference from the LP alone. In addition, the CS sharply decreases the platelet adhesion, which is found below the value observed for PET. The double cell labeling also showed that cells adhered on LP+CS has an anti-thrombotic phenotype and can resist blood flow. These studies suggest that a coating of CS is a promising strategy for vascular prosthesis given the combination of the good adhesion of endothelial cells and the low thrombogenicity of the underlying surface. Keywords: vascular prostheses, polymers, bioactive coating, thrombogenicity, HUVECs.

  7. Preseptal and Orbital Cellulitis

    OpenAIRE

    Emine Akçay; Gamze Dereli Can; Nurullah Çağıl

    2014-01-01

    Preseptal cellulitis (PC) is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC) is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites) or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epid...

  8. Etude et réalisation par coulage en bande et co-frittage de cellules de pile à combustible à oxydes solides

    OpenAIRE

    Grosjean, Arnaud

    2004-01-01

    L'introduction de nouveaux moyens de production d'énergie sur le marché dépend en partie de leur compétitivité. Le développement à bas coût d'un procédé de réalisation de cellules de piles à combustible à oxyde solide (SOFC), sujet de cette étude, s'inscrit dans une telle dynamique. Dans le cahier des charges défini au préalable, ont été fixés la méthode de mise en forme, -le coulage en bande-, ainsi que les matériaux, -la zircone yttriée, le nickel et le manganite de lanthane dopé au stronti...

  9. Etude de nouvelles cibles moleculaires de cancer bronchopulmonaire non a petites cellules pharmacomodulées par des substances originales naturelles et synthetiques

    OpenAIRE

    Moreau, Dimitri

    2006-01-01

    Maladie encore rare au début du 20ème siècle, le cancer du poumon est à l'origine de plus de 6 % des décès en France actuellement. Il occupe le premier rang des décès par cancer alors que la France est considérée comme un pays à risque moyen parmi les pays occidentaux. La découverte de nouveaux traitements anticancéreux toujours plus efficaces et spécifiques, est donc aujourd'hui primordiale. La validation de la capacité d'une molécule à pouvoir inhiber la prolifération cancéreuse, passe ...

  10. Cellulitis: diagnosis and management.

    Science.gov (United States)

    Bailey, Elizabeth; Kroshinsky, Daniela

    2011-01-01

    Cellulitis is an acute infection of the dermal and subcutaneous layers of the skin, often occurring after a local skin trauma. It is a common diagnosis in both inpatient and outpatient dermatology, as well as in the primary care setting. Cellulitis classically presents with erythema, swelling, warmth, and tenderness over the affected area. There are many other dermatologic diseases, which can present with similar findings, highlighting the need to consider a broad differential diagnosis. Some of the most common mimics of cellulitis include venous stasis dermatitis, contact dermatitis, deep vein thrombosis, and panniculitis. History, local characteristics of the affected area, systemic signs, laboratory tests, and, in some cases, skin biopsy can be helpful in confirming the correct diagnosis. Most patients can be treated as an outpatient with oral antibiotics, with dicloxacillin or cephalexin being the oral therapy of choice when methicillin-resistant Staphylococcus aureus is not a concern. PMID:21410612

  11. [Eosinophilic cellulitis (Wells' syndrome)].

    Science.gov (United States)

    Cerri, D; Carabelli, A; Bertani, E; Portaluppi, F; Novi, C; Gianotti, R; Gelmetti, C

    1990-09-01

    The Authors report a case of eosinophilic cellulitis (Wells' syndrome). The patient was a 61 year old woman, diabetic, with a cardio-respiratory insufficiency and a maniaco-depressive psycosis. She presented, on the upper arms and trunk, a cutaneous eruption of erythematous-urticarial plaques, that histopathologically were characterized by a dermic leukocyte population, with a prevalence of eosinophils, distributed in the perivascular site. Laboratory tests revealed eosinophilia and circulating immune complexes. The etiopathogenesis of the disease is discussed as is the possible role of immune complexes in eosinophilic cellulitis. PMID:2079351

  12. Fragmentation radioinduite de l'ADN et réparation étudiée par immunomarquage anti poly(ADP-ribose)polymérase (PARP) dans les cellules de hamster chinois (CHO)

    Science.gov (United States)

    Bidon, N.; Varlet, P.; Noël, G.; Demurcia, G.; Salamero, J.; Averbeck, D.

    1998-04-01

    The poly(ADP-ribose)polymerase is a nuclear ubiquitous enzyme capable of binding to DNA breaks. Chinese hamster ovary cells were (CHO-K1) cultured on slides and γ-irradiated (137Cs) at a high (12.8 Gy/min) or medium dose rate (5 Gy/min), and immunolabelling against (ADP-ribose) polymers immediatly or three hours after irradiation. Quantification and localisation of γ-ray induced breaks was performed by confocal microscopy. The results show a dose effect relationship, a dose-rate effect and the signal disappearence after 3 hours at 37 °C. The presence of PARP activity appears to reflect γ-rays induced DNA fragmentation. Le poly(ADP-ribose)polymérase est une enzyme nucléaire ubiquitaire capable de se fixer sur les cassures de l'ADN. Sur une lignée sauvage de cellules d'ovaire de hamster chinois (CHO-K1) cultivée sur lame et irradiée aux rayons γ à haut débit de dose (HD) 12,8 Gy/min ou à moyen débit de dose (MD) 5 Gy/min, nous avons réalisé un immunomarquage anti-polymères d'ADP-ribose immédiatement après l'irradiation γ ou après trois heures d'incubation à 37 °C. La quantification et la localisation des lésions radioinduites ont été réalisées par microscopie confocale. Les résultats montrent une relation dose-effet et un effet de débit de dose, ainsi qu'une disparition du signal après 3 heures à 37 °C. La présence de la PARP semble donc bien refléter la fragmentation radioinduite de l'ADN.

  13. Preseptal and orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Emine Akçay

    2014-09-01

    Full Text Available Preseptal cellulitis (PC is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, Haempphilus influenzae, Moraxella catarrhalis and S. pyogenes. The method for the diagnosis of OS and PS is computed tomography. Using effective antibiotics is a mainstay for the treatment of PC and OC. There is an agreement that surgical drainage should be performed in cases of complete ophthalmoplegia or significant visual impairment or large abscesses formation. This infections are also at a greater risk of acute visual loss, cavernous sinus thrombosis, meningitis, cerebritis, endophthalmitis, and brain abscess in children. Early diagnosis and appropriate treatment are crucial to control the infection. Diagnosis, treatment, management and complications of PC and OC are summarized in this manuscript. J MicrobiolInfect Dis 2014; 4(3: 123-127

  14. Odontogenic Facial Cellulitis

    Directory of Open Access Journals (Sweden)

    Yordany Boza Mejias

    2012-11-01

    Full Text Available Background: odontogenic facial cellulitis is an acute inflammatory process manifested in very different ways, with a variable scale in clinical presentation ranging from harmless well defined processes, to diffuse and progressive that may develop complications leading the patient to a critical condition, even risking their lives. Objective: To characterize the behavior of odontogenic facial cellulitis. Methods: A descriptive case series study was conducted at the dental clinic of Aguada de Pasajeros, Cienfuegos, from September 2010 to March 2011. It included 56 patients who met the inclusion criteria. Variables analyzed included: sex, age, teeth and regions affected, causes of cellulite and prescribed treatment. Results: no sex predilection was observed, lower molars and submandibular anatomical region were the most affected (50% and 30 4% respectively being tooth decay the main cause for this condition (51, 7%. The opening access was not performed to all the patients in the emergency service. The causal tooth extraction was not commonly done early, according to the prescribed antibiotic group. Thermotherapy with warm fomentation and saline mouthwash was the most prescribed and the most widely used group of antibiotics was the penicillin. Conclusions: dental caries were the major cause of odontogenic cellulite. There are still difficulties with the implementation of opening access.

  15. Understanding pediatric bacterial preseptal and orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Gonzalez Mithra

    2010-01-01

    Full Text Available Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Patients are usually treated with broad spectrum antibiotics and surgery when indicated.

  16. Evaluation of Pediatric Patients with Orbital and Preseptal Cellulitis

    Directory of Open Access Journals (Sweden)

    Eren Cagan

    2015-06-01

    Conclusion: Preseptal cellulitis is more frequently observed than orbital cellulitis. The most important predisposing factor for orbital cellulitis is sinusitis. Patients with preseptal cellulitis suspected clinically may be diagnosed with orbital cellulitis radiologically. As a result radiological imaging of preseptal cellulitis patients should be considered. [Cukurova Med J 2015; 40(2.000: 267-274

  17. Assessment and management of orbital cellulitis.

    Science.gov (United States)

    Amin, Nikul; Syed, Irfan; Osborne, Sarah

    2016-04-01

    Orbital cellulitis is a medical emergency requiring multidisciplinary team involvement. Early diagnosis and intervention is imperative to avoid serious complications. This article provides an evidence-based approach to the assessment and management of patients with orbital cellulitis. PMID:27071427

  18. ETUDE D’UNE CELLULE SOLAIRE PHOTOVOLTAIQUE A HETEROJONCTION n CdS /pCdTe

    OpenAIRE

    BENZEGHADI, Halima; OUDJAMAA, NABAWIYA

    2014-01-01

    Dans les cellules solaires à hétérojonction, le champ électrique créé par la gradient de la zone de charge d’espace permet de réduire le processus de la recombinaison superficielle. Ceci augmente la conductibilité et les performances des cellules solaires. Le tellurure de cadmium possède des propriétés cristallographiques et électriques très intéressantes le rendant ainsi très recherché pour la fabrication de cellules solaires. Dans cet ordre d’idées nous nous ...

  19. Etude d'une cellule photovoltaïque à jonction liquide : la cellule GaAs-n/(Se2-/Sen2-)/Pt

    OpenAIRE

    Bourrasse, A.; Cachet, H.; Horowitz, G.; Le Crom, S.

    1982-01-01

    Une étude de la cellule GaAs-n/(Se2- /Sen2- )/Pt, où l'électrode de GaAs est protégée contre la photo-décomposition par le couple redox séléniure/polyséléniure, est présentée. Un rendement énergétique de 11 % sous éclairement par une lampe à arc xénon a été atteint. La cellule a pu fonctionner pendant huit jours sous illumination solaire sans que l'on observe de baisse de ses performances. La faible décomposition de la photoanode est attribuée à la dégradation de l'électrolyte, provoquée par ...

  20. Rôle des régulateurs post-transcriptionnels Pumilio 1 et Pumilio 2 dans les cellules souches hématopoïétiques murines

    OpenAIRE

    Michelet, Fabio

    2013-01-01

    Les propriétés centrales des cellules souches sont la pluripotence et la capacité d'auto-renouvellement. Les cellules souches hématopoïétiques (CSHs) sont dotées de ces caractéristiques qui leur permettent de générer toutes les cellules du compartiment hématopoïétique, tout en maintenant en parallèle leur compartiment. Nous menons des approches visant à amplifier ex vivo les CSHs en les activant par HOXB4 exogène (CSHs humaines) ou via la signalisation Notch/DLL-4 (CSHs murines). Or deux anal...

  1. Expression de P53 dans les tumeurs à cellules géantes osseuses

    OpenAIRE

    Trottet, Cécile

    2001-01-01

    Le gène de la p53 est considéré comme un gène suppresseur de tumeur. Nous avons étudié son expression dans les tumeurs à cellules géantes osseuses (TCG) pour rechercher s'il pouvait être considéré comme un marqueur prédictif de l'évolution dans les TCG. La protéine p53 a été étudiée dans 33 cas de tumeurs à cellules géantes osseuses par immunohistochimie pour analyser son expression et par Single Strand Conformation Polymorphism (SSCP) pour rechercher la présence de mutations dans les tumeurs...

  2. Expression de P53 dans les tumeurs à cellules géantes osseuses

    OpenAIRE

    Trottet, Cécile; Borisch, Bettina; Bonjour, Jean-Philippe

    2005-01-01

    Le gène de la p53 est considéré comme un gène suppresseur de tumeur. Nous avons étudié son expression dans les tumeurs à cellules géantes osseuses (TCG) pour rechercher s'il pouvait être considéré comme un marqueur prédictif de l'évolution dans les TCG. La protéine p53 a été étudiée dans 33 cas de tumeurs à cellules géantes osseuses par immunohistochimie pour analyser son expression et par Single Strand Conformation Polymorphism (SSCP) pour rechercher la présence de mutations dans les tumeurs...

  3. Cellulitis

    Science.gov (United States)

    ... Eye Drops Lazy eye (defined) Pink eye (defined) Retinopathy of Prematurity Strabismus Stye (defined) Vision Screening Vision Screening Recommendations ... Eye Drops Lazy eye (defined) Pink eye (defined) Retinopathy of Prematurity Strabismus Stye (defined) Vision Screening Vision Screening Recommendations ...

  4. Cellules photo-électrochimiques à électrodes semiconductrices pour la conversion et le stockage de l'énergie solaire

    OpenAIRE

    Horowitz, G.; Bourrasse, A.

    1980-01-01

    Discipline récente, la conversion photo-électrochimique (PEC) de l'énergie solaire a connu ces dernières années un important effort de recherche. Les cellules PEC se caractérisent par la présence d'électrodes semiconductrices. L'étude théorique de leur fonctionnement, et en particulier de la stabilité des électrodes semiconductrices, conduit à distinguer deux types de cellules : les cellules autorégénérées, fournissant de l'énergie électrique, et les cellules de stockage, permettant la généra...

  5. Contribution à l’amélioration des performances des cellules solaires à base de InGaN.

    OpenAIRE

    Mostefaoui, Mohamed Amine

    2015-01-01

    L’énergie photovoltaïque convertit directement l’énergie Lumineuse en énergie électrique par des cellules solaires. Selon les besoins, l’électricité produite peut être utilisée pour l’alimentation d’un site isole ou revendue en tout ou partie au réseau de Distribution. Ce travail consiste à étudier et simuler une cellule solaire à base du matériau InGaN. Après avoir rappelé les caractéristiques d’une cellule solaire, l’influence des différents paramètres sur les caractéristi...

  6. Assoziationen zwischen endothelialer Dysfunktion und Adhäsionsmolekülen, sowie molekularen Markern der Entzündung bei Nachkommen von Typ-2-Diabetikern

    OpenAIRE

    Beckmann, Patrick

    2005-01-01

    Ziele: Die Atherosklerose korreliert eng mit dem Diabetes mellitus Typ 2. Als Grundlage vieler kardiovaskulärer Erkrankungen wird sie heute als eine chronische subklinische Entzündungsreaktion gesehen. Ein früher Marker in der Entwicklung der Atherosklerose ist die mittels hochauflösendem Ultraschall zu messende endotheliale Dysfunktion. Es wäre durchaus nützlich, einfache Verfahren zu finden, die eine Risikoabschätzung bezüglich der Diabetes- bzw. Atheroskleroseentwicklung ermöglichen. Da...

  7. Cellulitis Due to Salmonella infantis.

    Directory of Open Access Journals (Sweden)

    Satish R Patil

    2013-01-01

    Full Text Available Bacteria of the genus Salmonella are highly adapted for the growth in both humans and animals and cause a wide spectrum of disease. The growth of Serotypes S. typhi and S. paratyphi is restricted to human hosts, in whom these organisms cause enteric (typhoid fever. The remaining Serotypes (non typhoidal Salmonella or NTS can colonize the gastrointestinal tracts of the broad range of animals, including mammals, reptiles, birds and insects. The usual clinical presentation of non-typhoidal salmonellae (NTS infection is self limited gastroenteritis; however bacteremia and focal extra intestinal infection may occur. However salmonella localization to the skin presenting as cutaneous ulceration is regarded as a rare event. Rates of morbidity and mortality associated with NTS are highest among the elderly, infants, and immunocompromised individuals, including those with hemoglobinopathies, HIV infection, or infections that cause blockade of the reticuloendothelial system. We isolated S.infantis in 50 years old man with left leg cellulitis. The serotype was confirmed at Central Research Institute, Kasauli.

  8. Cellule Staminali di Glioblastoma: Terapia Oncolitica con Vettori Erpetici Ingegnerizzati

    OpenAIRE

    Sgubin, Donatella

    2014-01-01

    Il Glioblastoma (GBM), nonostante i migliori standard terapeutici, rimane una patologia a prognosi infausta. L’ipotesi delle Glioma Stem-like Cells (GSCs) prevede che, nella massa tumorale, sia presente una popolazione di cellule resistenti alla chemio e radioterapia e che tali cellule siano quindi le possibili responsabili della recidiva di malattia. Le GSCs, che possiedono caratteristiche comuni alle cellule staminali fisiologicamente presenti nel cervello adulto, sono cellule a lenta cresc...

  9. Cellulitis of the lower limbs: incidence, diagnosis and management

    OpenAIRE

    Atkin, Leanne

    2016-01-01

    Cellulitis is a common clinical condition that is often inaccurately diagnosed. Risk factors for the development of cellulitis include obesity, lymphoedema and lower limb ulceration. It is important to accurately diagnose and effectively treat cellulitis in order to provide cost effective care and reduce patient suffering. This article will deliver an overview on the burden of cellulitis, provide information that will aid accurate diagnosis and summarise current treatment options.

  10. Etude de la synthèse du resvératrol et de ses dérivés (viniférines) par des suspensions de cellules de vigne et optimisation de la production en bioréacteur

    OpenAIRE

    Chastang, Thomas

    2014-01-01

    Le travail effectué au cours de cette thèse a permis une avancée importante dans la connaissance de l’élicitation des cellules de vigne. Nous avons étudié les effets de deux éliciteurs, le méthyljasmonate et la méthyl-β-cyclodextrine, employés seuls et en élicitation croisée sur des suspensions de cellules de vigne (porte-greffe 41B et Vitis labrusca), pour la production de stilbènes (resvératrol et viniférines). Ceci a permis d’atteindre des concentrations de resvératrol très élevées pour un...

  11. Il controllo epigenetico di geni oncosoppressori nelle cellule staminali neuronali normali e di medulloblastoma

    OpenAIRE

    Begalli, Federica

    2013-01-01

    Le cellule staminali cerebellari normali fanno parte della grande famiglia delle cellule staminali somatiche, deputate a sostituire le cellule che muoiono per omeostasi fisiologica del tessuto o per un danno. Tali cellule mantengono alcune delle caratteristiche versatili delle cellule staminali embrionali. In particolare sono dotate della capacità di auto-rinnovamento indefinito e di multipotenza, difatti sono in grado di differenziare in più linee cellulari. Le cellule staminali neuronali ...

  12. Rôle de la signalisation TPO dans la réparation de l'ADN des cellules souches hématopoïétiques

    OpenAIRE

    De Lacoste De Laval, Bérengère

    2013-01-01

    A l'origine de l'hématopoïèse se trouve les cellules souches hématopoïétiques (CSH). Elles constituent un pool de cellules rares présentes dans la moelle osseuse aux niveaux de zones particulières de l'os appelées niche. Les cellules de la niche produisent des cytokines, telles que la thrombopoïétine (TPO), qui régulent les CSH en contrôlant leur quiescence et leur auto-renouvellement. Peu de choses sont connues sur les mécanismes mis en place par la CSH et son environnement pour faire face a...

  13. Cellulitis in a Red Kandhari Bull : A Case Report

    Directory of Open Access Journals (Sweden)

    M M Pathan

    2012-06-01

    Full Text Available A case of cellulitis caused by mixed infection of Staphylococcus spp. and Corynebacterium spp in a Red Kandhari bull leading to death of animal was autopsied at the department. It is being a case of cellulitis in a Red Kandhari bull and placed on record. [Vet. World 2012; 5(3.000: 183-184

  14. Sweet's syndrome associated with cellulitis - a challenging diagnosis*

    OpenAIRE

    Resende, C; Santos, R.; T. Pereira; Brito, C.

    2016-01-01

    Sweet's syndrome is a neutrophilic dermatosis with worldwide distribution that has been associated with inflammatory autoimmune diseases, infections, malignancies, drugs, and pregnancy. The disease is idiopathic in up to 50% of patients. A 64-year-old woman, diagnosed with right limb cellulitis (4 days of evolution), was seen at our department, due to persistent cellulitis and progressive appearance of painful nodules and plaques in both shins and the right forearm (2 days of evolution). Take...

  15. Facial cellulitis revealing choreo-acanthocytosis: a case report

    OpenAIRE

    Samia, Younes; Yosra, Cherif; Foued, Bellazreg; Mouna, Aissi; Olfa, Berriche; Jihed, Souissi; Hammadi, Braham; Mahbouba, Frih-Ayed; Amel, Letaief; Habib, Sfar Mohamed

    2014-01-01

    We report a 62 year-old-man with facial cellulitis revealing choreo-acanthocytosis (ChAc). He showed chorea that started 20 years ago. The orofacial dyskinisia with tongue and cheek biting resulted in facial cellulitis. The peripheral blood smear revealed acanthocytosis of 25%. The overall of chorea, orofacial dyskinetic disorder, peripheral neuropathy, disturbed behavior, acanthocytosis and the atrophy of caudate nuclei was suggestive of a diagnosis of ChAc. To our knowledge no similar cases...

  16. Effects of lymphatic drainage on cellulitis assessed by magnetic resonance

    OpenAIRE

    Patrícia Froes Meyer; Nara Mendes Martins; Flávia Mendes Martins; Rosimary Araújo Monteiro; Karla Morganna Pereira Pinto de Mendonça

    2008-01-01

    The aim of this study was to assess the use of magnetic resonance as a new method for evaluating the manual lymphatic drainage technique in treating cellulitis. Cellulitis is one of the main esthetic problems that lead women toward seeking guidance and specific treatments. There are various therapeutic approaches, owing to the multi-factorial nature of its pathogen, although the effectiveness of most of these has not been definitively proven, given that the assessment methods used are mostly ...

  17. Study of the cetuximab-ionizing radiation association on a model of in vitro endothelial cells; Etude de l'association cetuximab-radiations ionisantes sur un modele de cellules endotheliales in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Vautravers-Dewas, C.; Rebucci, M.; Lansiaux, A. [Centre Oscar-Lambret, Inserm U837, Lab. de Pharmacologie Antitumorale, 59 - Lille (France); Peixoto, P. [Inserm U837, 59 - Lille (France); Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2009-10-15

    These data support the existence of functional signalling tracks downstream epidermal growth factor receptor (E.G.F.R.) in endothelial cells. But our in vitro model, in two dimensional calculations, did not allow to show a radiosensitivity by cetuximab. The study of functional consequences of the association cetuximab-irradiation treatment will be relevant in an in vitro three dimensional model and on xenografts. (N.C.)

  18. Effet du stress oxydant sur les cavéoles dans les cellules musculaires squelettiques

    OpenAIRE

    Mougeolle, Alexis

    2014-01-01

    La sarcopénie est une maladie dégénérative liée à l’âge qui se caractérise par une perte progressive et involontaire de la masse et de la force musculaire. Elle s’accompagne d’une atteinte de la régénération musculaire et d’une accumulation des espèces réactives de l’oxygène. Les cavéoles sont des invaginations de la membrane plasmique. Dans le muscle, elles jouent un rôle dans la différenciation des cellules satellites et dans le maintien de l’unité contractile dans le muscle différencié. Ce...

  19. Synthèse et caractérisation de cellules pour pile à combustible de type IT-SOFC utilisée en tant que système APU dans les transports

    OpenAIRE

    Sivasankaran, Visweshwar,

    2014-01-01

    La fabrication de cellules de piles à combustible IT-SOFC de large dimension par un nouveau procédé simple et peu coûteux est présentée dans ce manuscrit. L’optimisation de ce nouveau procédé en regard de l’utilisation d’agents de porosité, d’épaisseur de couches et de température de frittage a été réalisée. Les résultats des tests électrochimiques sur des cellules de surface active 10 cm2 réalisés dans le dispositif Fiaxell semi-ouvert ont été détaillés pour différentes cellules. Des tests d...

  20. Ambient Ozone and Emergency Department Visits for Cellulitis

    Directory of Open Access Journals (Sweden)

    Mieczysław Szyszkowicz

    2010-11-01

    Full Text Available Objectives were to assess and estimate an association between exposure to ground-level ozone and emergency department (ED visits for cellulitis. All ED visits for cellulitis in Edmonton, Canada, in the period April 1992–March 2002 (N = 69,547 were examined. Case-crossover design was applied to estimate odds ratio (OR, and 95% confidence interval per one interquartile range (IQR increase in ozone concentration (IQR = 14.0 ppb. Delay of ED visit relating to exposure was probed using 0- to 5-day exposure lags. For all patients in the all months (January–December and lags 0 to 2 days, OR = 1.05 (1.02, 1.07. For male patients during the cold months (October-March: OR = 1.05 (1.02, 1.09 for lags 0 and 2 and OR = 1.06 (1.02, 1.10 for lag 3. For female patients in the warm months (April-September: OR = 1.12 (1.06, 1.18 for lags 1 and 2. Cellulitis developing on uncovered (more exposed skin was analyzed separately, observed effects being stronger. Cellulitis may be associated with exposure to ambient ground level ozone; the exposure may facilitate cellulitis infection and aggravate acute symptoms.

  1. Epidemiological characteristics of lower extremity cellulitis after a typhoon flood.

    Directory of Open Access Journals (Sweden)

    Pei-Chen Lin

    Full Text Available OBJECTIVE: The flood after a typhoon may lead to increase in patients with cellulitis of lower limbs. However, the microbiological features of these cases are rarely reported. We conducted a study of patients with lower extremity cellulitis after a typhoon followed in southern Taiwan to study the risk factors of cellulitis and the bacteriological features of the patients. METHODS: We reviewed all the medical records of cellulitis at emergency departments of two teaching hospitals in southern Taiwan 30 days before and after the landing of Typhoon Morakot and collected data on the demographic and bacteriological characteristics. In addition, we evaluated the relationship between the daily number of patients and the rainfall in the Tainan area. RESULTS: The number of cellulitis patients increased from 183 to 344 during the 30-day period after the typhoon. The number peaked in the third and fourth days and lasted for 3 weeks. The proportion of patients with water immersion of the affected limb was higher after the typhoon (6% vs. 37%, odds ratio [OR]: 9.0, 95% Confidence interval [CI]: 4.7-17.2. We found cultures from the infected limbs with immersion had more polymicrobial (73% vs. 26%, OR: 7.8, 95% CI: 3.2-19.2 and Gram-negative bacilli infection (86% vs. 34%, OR: 11.8, 95% CI: 4.1-34.5. CONCLUSIONS: Flood arose from Typhoon Morakot caused increases in cellulitis patients, which lasted for 3 weeks. Antibiotic treatment that were effective to both Gram-positive cocci and Gram-negative bacilli are recommended for patients with limbs emerged in the water.

  2. Orbital cellulitis following silicone-sponge scleral buckles

    Directory of Open Access Journals (Sweden)

    Nemet AY

    2013-10-01

    Full Text Available Arie Y Nemet, Joseph R Ferencz, Ori Segal, Amit Meshi Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel Background: Acute or chronic infection of the scleral explant is rare. We report seven cases of scleral explant infections that caused orbital cellulitis. Materials and methods: This was a retrospective chart review of oculoplastics at oculoplastics and vitreo-retinal units in a secondary referral hospital. All subjects had orbital cellulitis secondary to scleral buckle in the range of January 1990 to March 2010. Demographics, imaging studies, and pathology specimens were reviewed. Results: A total of 841 silicone-sponge scleral buckle implants for rhegmatogenous retinal detachment were performed. Forty were extracted (4.75%; annual rate of 1.9 cases. Seven (0.83% had orbital cellulitis. The mean time from implantation to presentation was 5.7 years. There was bacterial growth in all specimens, with Staphylococcus aureus in four. Conclusions: Patients who are operated on with silicone-sponge scleral buckling for rhegmatogenous retinal detachment sometimes require removal of the implant because of infection. However, the infection rate is low. Patients should be followed in the long term for possible complications. Keywords: scleral explant infection, scleral buckle, orbital cellulitis, rhegmatogenous retinal detachment

  3. Imagerie du réseau cellulaire osseux par nano-tomographie synchrotron

    OpenAIRE

    Joita Pacureanu, Alexandra

    2012-01-01

    Les ostéocytes sont les plus nombreuses cellules du tissu osseux, enterrées dans la matrice osseuse. Elles sont interconnectées par des dendrites, situées dans des canaux appelés canalicules. Les lacunes ostéocytaires, les cavités dans lesquelles les cellules sont logées, avec les canalicules forment un réseau de communication à travers la matrice osseuse, permettant le transport des nutriments et des signaux. Ces cellules, considérées d’abord passives, ont révélé dernièrement leur rôle en ta...

  4. Acetaminophen-induced cellulitis-like fixed drug eruption

    OpenAIRE

    Neila Fathallah; Chaker Ben Salem; Raoudha Slim; Lobna Boussofara; Najet Ghariani; Kamel Bouraoui

    2011-01-01

    Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption ...

  5. Pseudomonas aeruginosa bacteremia secondary to acute right leg cellulitis

    OpenAIRE

    Abdul Wahab, Asrul; Rahman, M.M.

    2013-01-01

    Pseudomonas aeruginosa is a gram-negative bacillus that causes wide spectrum clinical infections. However, it is most frequently associated with hospital-acquired infection. In this case a 58-year-old male with underlying hypertension and dyslipidaemia was admitted for acute right leg cellulitis. Pseudomonas aeruginosa was identified from the case, though it was not a usual suspected organism. It might be due to community-acquired infection.

  6. Posttraumatic Fat Necrosis Presented as Cellulitis of the Leg

    Directory of Open Access Journals (Sweden)

    Einat Haikin Herzberger

    2012-01-01

    Full Text Available Cellulitis, a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin, is a common lesion in children, usually responsive to systemic antibiotic therapy. However, an unusual course of healing or some nontypical features should call the treating physician to consider and investigate for other diagnoses that might prevent unnecessary treatment and alleviate parental stress. We present a case of posttraumatic fat necrosis, demonstrating some pitfalls in the process of diagnosis.

  7. Group a streptococcal cellulitis in the early puerperium

    OpenAIRE

    Nikolić Branka; Mitrović Ana; Dragojević-Dikić Svetlana; Rakić Snežana; Cakić Zlatica; Saranović Milena; Sikimić Milan

    2011-01-01

    Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS) are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerp...

  8. Etude théorique des cellules solaires PV organiques: structure réseau interpénétré polymère conjugué-fullerène et cellules Graetzel

    OpenAIRE

    Zakaria, BOUZID

    2014-01-01

    Le photovoltaïque est aujourd'hui une technologie d'énergie renouvelable en plein essor. La croissance du marché a été comprise entre 15% et 20% durant la dernière décennie. Malgré le développement des matériaux et des méthodes de fabrication fortement soutenus par la croissance de l'industrie des semi-conducteurs, le coût des cellules solaires est resté élevé. Cependant, de nouveaux matériaux photovoltaïques ont été développés durant les dernières années, cela pourrait bien ouvri...

  9. Capacità immunomodulatrice delle cellule staminali mesenchimali di cavallo da midollo osseo: risultati preliminari su cellule mononucleate

    OpenAIRE

    Riccò, Sarah

    2010-01-01

    Negli ultimi anni è emerso l’uso delle MSCs (multipotent mesenchymal stromal cells) nella medicina rigenerativa soprattutto per la terapia dei tendini e dei legamenti nel cavallo. La terapia con MSCS allogeniche potrebbe essere un utile strumento quando non è possibile isolare e amplificare le cellule del paziente. L’attività immunomodulatrice delle MSCS è stata studiata in diverse specie animali e nell’uomo ma nessun dato è stato riportato nel cavallo. In questo lavoro abbiamo riportato la c...

  10. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  11. Clinical and microbiologic features of dacryocystitis-related orbital cellulitis.

    Science.gov (United States)

    Wladis, Edward J; Shinder, Roman; LeFebvre, Daniel R; Sokol, Jason A; Boyce, Michelle

    2016-10-01

    Dacryocystitis-related orbital cellulitis is a relatively rare condition, and large case series of this clinical entity have been reported. This study was undertaken to identify a larger cohort of patients with this ailment, with the intent of defining its clinical and microbiologic features. Case logs from four institutions were reviewed to identify patients that suffered from dacryocystitis-related orbital cellulitis. A retrospective chart review was then performed to identify clinical features, management strategies, microbiologic features, and outcomes. A dedicated statistical software package was utilized to identify correlations between these variables. 13 patients (7 females, 6 males; mean age = 57.2 years, range = 7-89 years) were identified. One patient carried a diagnosis of immunosuppressive disease. All patients underwent emergent surgical drainage and received intravenous antibiotics. Primary acquired nasolacrimal duct obstruction was found to be the underlying etiology in nine cases (69.2%), whereas four patients suffered from specific causes of their obstructions. An average of 1.07 organisms/patient (standard deviation = 0.49 organisms/patient) were recovered from microbiologic cultures, and Gram-positive bacteria represented the majority of cultured organisms. All patients experienced either stable or improved vision upon discharge. The relationships between a specific etiology and the possibility of vision loss or the number of organisms cultured, between the number of organisms cultured and vision loss, and immunosuppression and vision loss or the number of organisms cultured were all not statistically significant (p > 0.05). Dacryocystitis-related orbital cellulitis most commonly occurs in adult patients who do not carry immunosuppressive diagnoses and suffer from primary obstructions. Multiple microbiologic species may cause this problem, although Gram-positive organisms are most common. With appropriate management, stable or improved vision

  12. Antimicrobial resistance of bacterial strains isolated from avian cellulitis

    Directory of Open Access Journals (Sweden)

    MM Santos

    2014-03-01

    Full Text Available Avian cellulitis is an inflammatory process in the subcutaneous tissue, mainly located in the abdomen and thighs. This problem is commonly observed in poultry at slaughter and it is considered one of the major causes of condemnation of carcasses in Brazil. The aim of this study was to perform the microbial isolation of lesions of avian cellulitis from a processing plant located in the State of Goiás in order to analyze antimicrobial resistance by antibiogram test and to detect resistance genes by polymerase chain reaction. A total of 25 samples of avian cellulitis lesions were analyzed, from which 30 bacterial strains were isolated. There were eleven (44% strains of Escherichia coli, nine (36% strains of Staphylococcus epidermidis, seven (28% strains of Proteus mirabilis and three (12% strains of Manheimiahaemolytica. The antibiogram test showed that all strains were resistant to at least one antimicrobial. The gene of antimicrobial resistance tetB was detected in E. coli, S. epidermidis and P. mirabilis strains, and was the most frequently observed gene. The gene of antimicrobial resistance Sul1 was detected in all bacterial species, while tetA was found in E. coli and S. epidermidis strains, SHV in E. coli strains, S. epidermidis and P. mirabilis,and cat1 in one P. mirabilis strain. The results suggest a potential public health hazard due to the ability of these microorganisms to transmit antimicrobial resistancegenes to other microorganisms present in the intestinal tract of humans and animals, which may affect clinical-medical usage of these drugs.

  13. Prevalence and Epidemiological Factors Involved in Cellulitis in Korean Patients With Lymphedema

    Science.gov (United States)

    Park, Sae In; Yang, Eun Joo; Kim, Dong Kyu; Jeong, Ho Joong; Kim, Ghi Chan

    2016-01-01

    Objective To evaluate the prevalence and associated factors involved in cellulitis with lymphangitis among a group of Korean patients who were being treated for lymphedema. We present our epidemiologic research and we also report a systematic review of these types of cases. Methods This was a retrospective medical record study among 1,246 patients diagnosed with lymphedema. The study was carried out between January 2006 and December 2012 at the Kosin University Gospel Hospital and Seoul National University Bundang Hospital. Cases were examined for onset time, affected site, seasonal trend, and recurrence pattern of lymphedema, lymphangitis, and cellulitis. We also evaluated the history of blood-cell culture and antibiotic use. Results Ninety-nine lymphedema patients experienced complications such as cellulitis with accompanying lymphangitis. Forty-nine patients had more than two recurrences of cellulitis with lymphangitis. The incidence and recurrence of cellulitis with lymphangitis were significantly higher in the patients with lower-extremity lymphedema. There was a significant trend toward higher cellulitis prevalence in the lower-extremity lymphedema group according to the time of lymphedema onset. Among the cellulitis with lymphangitis cases, 62 cases were diagnosed through blood-cell culture; 8 of these 62 cultures were positive for β-hemolytic streptococci. Conclusion The prevalence rate of cellulitis with lymphangitis in patients with lymphedema was 7.95%, and the prevalence of recurrent episodes was 3.93%. Especially, there was high risk of cellulitis with lymphangitis after occurrence of lower-extremity lymphedema with passage of time. Lymphedema patients should be fully briefed about the associated risks of cellulitis before treatment, and physicians should be prepared to provide appropriate preventive education. PMID:27152284

  14. Erosive pustular dermatosis of the leg mimicking lower limb cellulitis.

    Science.gov (United States)

    Zhou, Z; Zhang, Z K; Liu, T H

    2015-12-01

    Erosive pustular dermatosis (EPD) of the leg is an unusual form of amicrobial pustulosis, which typically affects elderly patients with chronic venous insufficiency. We report a patient who presented with painful erythema, crusted erosions and pustules on her right lower leg. Histology showed a dermal infiltration made up predominantly of neutrophils. Bacteria were isolated from the lesions. The condition was initially diagnosed as cellulitis, but antibiotic treatment was unsuccessful. After the correct diagnosis was made, complete resolution was obtained with betamethasone 0.05%. PMID:25476720

  15. Acute neck cellulitis and mediastinitis complicating a continuous interscalene block.

    Science.gov (United States)

    Capdevila, Xavier; Jaber, Samir; Pesonen, Pertti; Borgeat, Alain; Eledjam, Jean-Jacques

    2008-10-01

    We report a case of acute neck cellulitis and mediastinitis complicating a continuous interscalene brachial plexus block. A 61-yr-old man was scheduled for an elective arthroscopic right shoulder rotator cuff repair. A continuous interscalene block was done preoperatively and 20 mL of 0.5% bupivacaine and 20 mL of 2% mepivacaine were injected through the catheter. Postoperative analgesia was provided by a continuous infusion of bupivacaine, 0.25% at 5 mL/h for 39 h using a 240-mL elastomeric disposable pump. The day after surgery, the patient complained of neck pain. The analgesic block was not fully effective. He was discharged home. Three days later, the patient was readmitted with neck edema and erythema, fever and fatigue. Neck ultrasonography and computed tomographic scan revealed an abscess of the interscalene and sternocleidomastiod muscles and cellulitis, as well as acute mediastinitis. Two blood cultures and surgical samples were positive for Staphylococcus aureus. The infection was treated with surgery, the site was surgically debrided, and a 2-mo course of vancomycin, imipenem, and oxacilline. The technique of drawing local anesthetic from the bottle and filling the elastomeric pump was the most likely cause of infection. This case emphasizes the importance of strict aseptic conditions during puncture, catheter insertion, and management of the local anesthetic infusate. PMID:18806062

  16. Caracterisations des cellules photovoltaiques a base des ôlymeres conducteurs

    OpenAIRE

    ANSRI, Amel

    2012-01-01

    Ce travail de recherche est porté sur la caractérisation des cellules photovoltaïques organiques. Le développement de ces cellules constitue un grand enjeu de la filière électronique organique. Ces cellules sont aussi prometteuses pour la production d'énergie à bas coût. Elles peuvent être fabriquées sur substrat souple, ce qui leur permettra une intégration facile dans les appareils nomades comme les téléphones portables et les ordinateurs portables. Dans ce cadre et dans le but ...

  17. Effects of lymphatic drainage on cellulitis assessed by magnetic resonance

    Directory of Open Access Journals (Sweden)

    Patrícia Froes Meyer

    2008-12-01

    Full Text Available The aim of this study was to assess the use of magnetic resonance as a new method for evaluating the manual lymphatic drainage technique in treating cellulitis. Cellulitis is one of the main esthetic problems that lead women toward seeking guidance and specific treatments. There are various therapeutic approaches, owing to the multi-factorial nature of its pathogen, although the effectiveness of most of these has not been definitively proven, given that the assessment methods used are mostly subjective or do not provide enough information on subcutaneous tissue. The introduction of magnetic resonance as a means of assessing a lymphatic drainage technique in cellulitis treatment makes the evaluation more accurate, since it enables a detailed study of subcutaneous architecture.Objetivo: Este estudo objetiva avaliar o uso da Ressonância Magnética como uma nova técnica de avaliação de uma técnica de drenagem linfática no tratamento do Fibro Edema Gelóide (FEG. O FEG, popularmente conhecido como "celulite" é um dos principais problemas de estética corporal que leva as mulheres a procurar orientações e tratamentos específicos. Devido à natureza multifatorial da sua patogenia, existem várias abordagens terapêuticas, mas a maioria desses não tem sua eficácia comprovada de maneira acurada, pois os métodos de avaliação utilizados, em sua maioria, são subjetivos ou não provêem informações suficientes para o estudo do tecido subcutâneo. A introdução da ressonância magnética como meio de avaliação de uma técnica de drenagem linfática no tratamento do FEG a torna mais acurada, uma vez que a mesma possibilita o estudo detalhado da arquitetura do subcutâneo.

  18. Acetaminophen-induced cellulitis-like fixed drug eruption

    Directory of Open Access Journals (Sweden)

    Neila Fathallah

    2011-01-01

    Full Text Available Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption induced by acetaminophen was considered especially with a reported history of a previous milder reaction occurring in the same site. Acetaminophen was withdrawn and the rash improved significantly. According to the Naranjo probability scale, the eruption experienced by the patient was probably due to acetaminophen. Clinicians should be aware of the ability of acetaminophen to induce fixed drug eruption that may clinically take several aspects and may be misdiagnosed.

  19. Prospective study on sociodynamics of cellulitis in general surgical unit

    Directory of Open Access Journals (Sweden)

    Didde Sundara Chakravarthy

    2015-05-01

    Results: The median age of the participants was 62.5 years. The following risk factors were strongly and independently associated with cellulitis and outcome of the patient; illiteracy (OR, 4; P value 0.010, age above 50 years (OR, 0.110; P value 0.000, residing in rural areas (OR, 4.008; P value 0.006, low socioeconomic status (OR, 0.241; P value 0.030 and associated co-morbid conditions (OR, 0.390; P value, 0.032. Conclusion: Patients usually presented in the late stage of disease because of illiteracy, ignorance and poor knowledge. Patients should be educated to routinely inspect their feet, and the importance of appropriate footwear should be emphasized. Patients who are actively involved in their care can improve their quality of life and have a better outcome. [Int J Res Med Sci 2015; 3(5.000: 1052-1055

  20. Recurrent cellulitis with benzathine penicillin prophylaxis is associated with diabetes and psoriasis.

    Science.gov (United States)

    Karppelin, M; Siljander, T; Huhtala, H; Aromaa, A; Vuopio, J; Hannula-Jouppi, K; Kere, J; Syrjänen, J

    2013-03-01

    Risk factors for recurrent cellulitis were assessed in a case-control study including 398 patients receiving prophylactic treatment with benzathine penicillin and 8,005 controls derived from a national population-based health survey. In the multivariate analysis, psoriasis [odds ratio (OR) 3.69], other chronic dermatoses (OR 4.14), diabetes (OR 1.65), increasing body mass index (OR 1.17), increasing age (OR 1.06) and history of previous tonsillectomy (OR 6.82) were independently associated with recurrent cellulitis. Forty percent of the patients reported a cellulitis recurrence, despite ongoing benzathine penicillin prophylaxis. The role of previous tonsillectomy in recurrent cellulitis needs further evaluation. PMID:23007460

  1. Amélioration de l’efficacité de l’absorption du rayonnement solaire photovoltaïque par utilisation des nanostructures.

    OpenAIRE

    TRAORE Soumaïla, Amara

    2014-01-01

    L’absorption complète de la lumière solaire dans le silicium cristallin nécessite une épaisseur de matériau de l’ordre de 500 microns, une large fraction de la lumière est perdue par transmission lorsque l’épaisseur de matériau diminue en deçà de 10 microns. Les cellules photovoltaïques en couches minces (cellules de 2ème génération) tentent de contourner les difficultés rencontrées par cette traditionnelle technologie en minimisant la quantité de matière active semi-conductrice par kWh insta...

  2. Histiocytoid giant cellulitis-like Sweet’s syndrome: case report and review of the literature

    OpenAIRE

    So, Jessica Kim; Carlos, Casey A; Frucht, Corey S.; Cohen, Philip R.

    2015-01-01

    Background: Histiocytoid Sweet syndrome is an uncommon variant in which the dermal infiltrate is composed of mononuclear cells with a histiocytic appearance that represent immature myeloid cells. Giant cellulitis-like Sweet syndrome is a recently described variant characterized by relapsing widespread giant lesions. Purpose: We report a unique patient with histiocytoid giant cellulitis-like Sweet syndrome and review the current literature on histiocytoid Sweet syndrome and giant cell...

  3. Is Procalcitonin a usefull biomarker for the risk stratification of facial cellulitis?

    OpenAIRE

    Bertolus, Chloé; Schouman, Thomas; Aubry, Adeline; Hausfater, Pierre

    2016-01-01

    International audience Backgroundfacial cellulitis is an infectious disease that may require emergency surgical drainage based on clinical assessment. To date, no biological marker has been reported to be useful for risk stratification. Procalcitonin (PCT) is a diagnostic and prognostic sepsis biomarker. We aimed to study the usefulness of PCT dosage for the risk-stratification of facial cellulitis.Patients and methodsThis was a monocentric prospective study conducted in a referral center ...

  4. Peg-Interferon Alfa 2-b Related Cellulitis in a 40 Years Man

    Directory of Open Access Journals (Sweden)

    Shahnaaz Sali

    2016-01-01

    Full Text Available Background: Pegylated interferon and ribavirin are currently one of the accepted treatment for chronic Hepatitis C. Dermatologic complications of interferon have been reported, but to date a few cases of bacterial cellulitis; a rare and severe complication, have been published. Cellulitis is a common infectious process affecting the skin and subcutaneous tissues which results in significant morbidity and holds considerable healthcare costs.Cases Report: Herein, we report a case of chronic hepatitis C genotype 1a who was on medication since 8 weeks prior to developing leg cellulitis, an uncommon pegylated interferon injection site. Considering no other possible risk factors were found to be in favor of bacterial cellulitis, our case is unique in its kind. Some reports reveal necrotizing vasculitis as basis for cutaneous lesions, which could be due to the high concentrations of drug at the injection site, a toxic effect of the diluents, or an immunological reaction.Conclusion: According to the latter mechanism patients could develop bacterial cellulitis in their different organs. Conclusively, we propose the hypothesis of a possible association between cellulitis to occur at any site as the complication of pegylated interferon Alfa 2b and would highlight the role of a careful skin examination that could be an asset in preventing local skin infections.

  5. Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.

    Science.gov (United States)

    Räßler, F; Lukács, J; Elsner, P

    2016-09-01

    Eosinophilic cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well-designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions. PMID:27357601

  6. Cervical cellulitis and mediastinitis following esophageal perforation: A case report

    Institute of Scientific and Technical Information of China (English)

    Christian A Righini; Basilide Z Tea; Emile Reyt; Karim A Chahine

    2008-01-01

    Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation.Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management.We present the case of a 52-year-old man who sustained an upper esophageal perforation associated with cervical cellulitis and mediastinitis.Following CT-scan evidence of FB penetrating the esophagus,the impacted FB was successfully extracted under rigid esophagoscopy.Direct suture was required to close the esophageal perforation.Cervical and mediastinal drainage were made immediately.Nasogastric tube decompression,broad-spectrum intravenous antibiotics,and parenteral hyperalimentation were administered for 10 d postoperatively.An esophagogram at d 10 revealed no leak at the repair site,and oral alimentation was successfully reinstituted.Conclusion:Rigid endoscope management of FB esophageal penetration is a simple,safe and effective procedure.Primary esophageal repair with drainage of all affected compartments are necessary to avoid life-threatening complications.

  7. Cancer bronchique à petites cellules et grossesse: à propos d'un cas avec revue de la literature

    Science.gov (United States)

    Safini, Fatima; Jjouhadi, Hassan; Chehal, Asmaa; Mernissi, Farida; Wilfried, Akpoo; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2016-01-01

    Le cancer broncho-pulmonaire (CBP) de la femme enceinte est une entité rare, d’évolution péjorative. Cette situation devient de plus en plus fréquente, du fait de l'augmentation du tabagisme chez la femme. La transmission tumorale trans-placentaire avec atteinte fœtale est décrite surtout chez les femmes non traitées. Le traitement est multidisciplinaire et n'est pas bien codifié. Nous rapportons le cas d'une patiente de 23 ans chez qui le diagnostic d'un carcinome bronchique à petites cellules a été fait au cours de sa grossesse. Elle avait bénéficié d'une chimiothérapie pendant la grossesse, bien tolérée. L’évaluation radiologique a objectivé une stabilisation du processus pulmonaire. Le traitement a été complété par une association radio-chimiothérapie concomitante après l'accouchement. PMID:27279957

  8. Evidence of streptococcal origin of acute non-necrotising cellulitis: a serological study.

    Science.gov (United States)

    Karppelin, M; Siljander, T; Haapala, A-M; Aittoniemi, J; Huttunen, R; Kere, J; Vuopio, J; Syrjänen, J

    2015-04-01

    Bacteriological diagnosis is rarely achieved in acute cellulitis. Beta-haemolytic streptococci and Staphylococcus aureus are considered the main pathogens. The role of the latter is, however, unclear in cases of non-suppurative cellulitis. We conducted a serological study to investigate the bacterial aetiology of acute non-necrotising cellulitis. Anti-streptolysin O (ASO), anti-deoxyribonuclease B (ADN) and anti-staphylolysin (ASTA) titres were measured from acute and convalescent phase sera of 77 patients hospitalised because of acute bacterial non-necrotising cellulitis and from the serum samples of 89 control subjects matched for age and sex. Antibiotic treatment decisions were also reviewed. Streptococcal serology was positive in 53 (69%) of the 77 cases. Furthermore, ten cases without serological evidence of streptococcal infection were successfully treated with penicillin. Positive ASO and ADN titres were detected in ten (11%) and three (3%) of the 89 controls, respectively, and ASTA was elevated in three patients and 11 controls. Our findings suggest that acute non-necrotising cellulitis without pus formation is mostly of streptococcal origin and that penicillin can be used as the first-line therapy for most patients. PMID:25403372

  9. Group a streptococcal cellulitis in the early puerperium

    Directory of Open Access Journals (Sweden)

    Nikolić Branka

    2011-01-01

    Full Text Available Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerperium. However, there are two main problems with GAS infection in early puerperium and this case report is aimed at reminding on them. The first problem is an absence of awareness that it can be postpartal invasive GAS infection before the microbiology laboratory confirms it, and the second one is that we have little knowledge about GAS infection, in general. Case report. A 32- year-old healthy woman, gravida 1, para 1, was hospitalized three days after vaginal delivery with a 38-hour history of fever, pain in the left leg (under the knee, and head injury after short period of conscious lost. Clinical picture of GAS infection was cellulites. Group A Streptoccocus pyogenes was isolated in vaginal culture. Rapid antibiotic and supportive treatment stopped development of streptococcal toxic shock syndrome (STSS and potential multiorganic failure. Signs and symptoms of the infection lasted 25 days, and complete recovery of the patient almost 50 days. Conclusion. In all women in childbed with a history of fever early after delivery, vaginal and cervical culture specimens should be taken as soon as possible. Early recognition of GAS infection in early puerperium and prompt initiation of antimicrobial drug and supportive therapy can prevent development of STSS and lethal outcome.

  10. Delayed breast cellulitis: An evolving complication of breast conservation

    International Nuclear Information System (INIS)

    Purpose: Delayed breast cellulitis (DBC) is characterized by the late onset of breast erythema, edema, tenderness, and warmth. This retrospective study analyzes the risk factors and clinical course of DBC. Methods and Materials: From 1985 through 2004, 580 sequential women with 601 stage T0-2N0-1 breast cancers underwent breast conserving therapy. Cases of DBC were identified according to accepted clinical criteria: diffuse breast erythema, edema, tenderness, and warmth occurring >3 months after definitive surgery and >3 weeks after radiotherapy. Potential risk factors analyzed included patient comorbidity, operative technique, acute complications, and details of adjunctive therapy. Response to treatment and long-term outcome were analyzed to characterize the natural course of this syndrome. Results: Of the 601 cases, 16%, 52%, and 32% were Stage 0, I, and II, respectively. The overall incidence of DBC was 8% (50/601). Obesity, ecchymoses, T stage, the presence and aspiration of a breast hematoma/seroma, removal of >5 axillary lymph nodes, and arm lymphedema were significantly associated with DBC. The median time to onset of DBC from the date of definitive surgery was 226 days. Ninety-two percent of DBC patients were empirically treated with antibiotics. Fourteen percent required more invasive intervention. Twenty-two percent had recurrent episodes of DBC. Ultimately, 2 patients (4%) underwent mastectomy for intractable breast pain related to DBC. Conclusion: Although multifactorial, we believe DBC is primarily related to a bacterial infection in the setting of impaired lymphatic drainage and may appear months after completion of radiotherapy. Invasive testing before a trial of antibiotics is generally not recommended

  11. A case of community-acquired Acinetobacter junii-johnsonii cellulitis.

    Science.gov (United States)

    Henao-Martínez, Andrés F; González-Fontal, Guido R; Johnson, Steven

    2012-06-01

    Acinetobacter skin and soft tissue infection outside of the traumatic wound setting are rare occurrences. The majority of cases occur in the presence of significant comorbilities and by Acinetobacter baumanii. Herein a case is reported of community-onset, health-care-associated, non-traumatic cellulitis caused by Acinetobacter, species junii-johnsonii with bacteremia. This is the first reported case of Acinetobacter junii-johnsonii skin and soft tissue infection. Hemorrhagic bullae might be one of the clinical features of Acinetobacter cellulitis. PMID:23242290

  12. Systèmes effecteurs de l'immunité innée : reconnaissance et voies de signalisation.
    - Etude structurale des propriétés de reconnaissance des ficolines et du C1q
    - Etude cellulaire du rôle de la protéine ELMO1 dans l'élimination des cellules apoptotiques

    OpenAIRE

    Garlatti, Virginie

    2008-01-01

    Le système immunitaire inné génère des réponses inflammatoires contre les pathogènes ou les cellules dangereuses mais est aussi impliqué dans l'élimination tolérogène des cellules apoptotiques. La reconnaissance des cibles est médiée par un grand nombre de protéines membranaires et solubles. Parmi celles-ci, on trouve les protéines de reconnaissance du complément : C1q, MBL (« mannose-binding lectin) et ficolines. Bien que les propriétés structurales de reconnaissances de la MBL aient été ext...

  13. Penetration of Fosfomycin into Inflammatory Lesions in Patients with Cellulitis or Diabetic Foot Syndrome

    OpenAIRE

    Legat, F. J.; Maier, A.; Dittrich, P.; Zenahlik, P.; Kern, T.; Nuhsbaumer, S.; Frossard, M.; Salmhofer, W.; Kerl, H; Müller, M

    2003-01-01

    We investigated the distribution of the broad-spectrum antibiotic fosfomycin in infected soft tissue of patients with uncomplicated cellulitis of the lower extremities or diabetic foot infection using in vivo microdialysis. Our findings suggest that fosfomycin exhibits good and similar penetration into the fluid in the interstitial space in inflamed and noninflamed soft tissue in patients.

  14. Panophthalmitis with orbital cellulitis following glaucoma drainage implant surgery in a pediatric patient

    Directory of Open Access Journals (Sweden)

    Bruno L. B. Esporcatte

    2016-04-01

    Full Text Available ABSTRACT Here we report a case of childhood glaucoma refractory to angle and trabeculectomy surgery. The patient was treated with an Ahmed™ drainage implant that was subsequently complicated by rapid-onset panophthalmitis and orbital cellulitis. Intravenous and intravitreal antibiotic therapy was initiated and the drainage tube was removed. The infectious process resolved within 3 weeks; however, phthisis bulbi developed subsequently.

  15. Factors predisposing to acute and recurrent bacterial non-necrotizing cellulitis in hospitalized patients: a prospective case-control study.

    Science.gov (United States)

    Karppelin, M; Siljander, T; Vuopio-Varkila, J; Kere, J; Huhtala, H; Vuento, R; Jussila, T; Syrjänen, J

    2010-06-01

    Acute non-necrotizing cellulitis is a skin infection with a tendency to recur. Both general and local risk factors for erysipelas or cellulitis have been recognized in previous studies using hospitalized controls. The aim of this study was to identify risk factors for cellulitis using controls recruited from the general population. We also compared patients with a history of previous cellulitis with those suffering a single episode, with regard to the risk factors: length of stay in hospital, duration of fever, and inflammatory response as measured by C-reactive protein (CRP) level and leukocyte count. Ninety hospitalized cellulitis patients and 90 population controls matched for age and sex were interviewed and clinically examined during the period April 2004 to March 2005. In multivariate analysis, chronic oedema of the extremity, disruption of the cutaneous barrier and obesity were independently associated with acute cellulitis. Forty-four (49%) patients had a positive history (PH) of at least one cellulitis episode before entering the study. Obesity and previous ipsilateral surgical procedure were statistically significantly more common in PH patients, whereas a recent (<1 month) traumatic wound was more common in patients with a negative history (NH) of cellulitis. PH patients had longer duration of fever and hospital stay, and their CRP and leukocyte values more often peaked at a high level than those of NH patients. Oedema, broken skin and obesity are risk factors for acute cellulitis. The inflammatory response as indicated by CRP level and leukocyte count is statistically significantly more severe in PH than NH patients. PMID:19694769

  16. Etude des phenomenes chimiques au contact entre le bloc cathodique et la barre collectrice d'une cellule d'electrolyse d'aluminium

    Science.gov (United States)

    Lebeuf, Martin

    La production d'aluminium est une industrie importante au Québec. Les propriétés de ce métal le vouent à de multiples usages présents et futurs dans le cadre d'une économie moderne durable. Toutefois, le procédé Hall-Héroult est très énergivore et des progrès demeurent donc nécessaires pour en diminuer les coûts financiers et environnementaux. Parmi les améliorations envisageables de la cellule d'électrolyse se trouve le contact entre la cathode et la barre collectrice, qui doit offrir une faible résistivité au passage du courant électrique. En cours d'opération de la cellule, ce contact a tendance à se dégrader, générant des pertes énergétiques significatives. Les causes de cette dégradation, pouvant provenir de phénomènes chimiques, thermiques, mécaniques et/ou électriques, demeurent mal comprises. Le but du présent projet était donc d'étudier les phénomènes chimiques se produisant au contact bloc-barre de la cellule d'électrolyse Hall-Héroult. En premier lieu, un aspect crucial à considérer est la pénétration du bain électrolytique dans la cathode, car des composés de bain atteignent éventuellement la barre collectrice et peuvent y réagir. A cet effet, une méthode novatrice a été développée afin d'étudier les cathodes et la pénétration du bain dans celles-ci à l'aide de la microtomographie à rayons X. Cette méthode rapide et efficace s'est avérée fort utile dans le projet et a un potentiel important pour l'étude future des cathodes et des phénomènes qui s'y produisent. Ensuite, une cellule d'électrolyse rectangulaire à petite échelle a été développée. Plusieurs phénomènes observés 'en industrie sur des autopsies de cellules post-opération et rapportés dans la littérature ont été reproduis avec succès à l'aide de cette cellule expérimentale. Puis, des tests sans électrolyse, ciblant l'effet du bain électrolytique sur l'acier, ont aussi été conçus et complétés afin de s

  17. Nine years′ review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

    Directory of Open Access Journals (Sweden)

    Datta G Pandian

    2011-01-01

    Full Text Available Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Settings and Design : Retrospective descriptive case study done in a tertiary care hospital in South India. Material and Methods: The in-patient records of patients with preseptal and orbital cellulitis were reviewed from 1998 to 2006. The factors reviewed included ocular findings aiding in the distinction of the two clinical conditions, the duration of symptoms, the duration of hospital stay, microbiological culture report of pus or wound swab, blood culture, drugs used for treatment, the response to therapy and complications. Statistical Analysis Used: Descriptive analysis. Results: One hundred and ten cases, 77 patients with preseptal cellulitis and 33 patients with orbital cellulitis were reviewed. Five percent of children and 21% of adults presented with cutaneous anthrax contributing to preseptal cellulitis. Thirty-nine percent cases with orbital cellulitis were caused by methicillin-resistant Staphylococcus aureus (MRSA. Conclusions: This study has helped in identifying organisms which cause orbital infections, especially community-acquired MRSA. It indicates the need for modifying our empirical antimicrobial therapy, especially in orbital cellulitis.

  18. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    OpenAIRE

    Soma Mukherjee; Surbhi Sharma; Laxmi Maru

    2013-01-01

    Ludwig's angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregn...

  19. Quantification des cellules viables de P. phosphoreum dans les pavés de saumon cru par PCR temps reel

    DEFF Research Database (Denmark)

    Macé, Sabine; Mamlouk, Kelthoum; Chipchakova, Stoyka;

    de 350 pb sur le gène de la gyrase subunit B de P.phosphoreum. Leur spécificité a été démontrée en utilisant l’ADN de 88 souches bactériennes de 52 espèces bactériennes différentes. En utilisant ces amorces pour quantifier une culture pure de P.phosphoreum, une bonne corrélation (R2 de 0.99) a été...

  20. Glycosphingolipides et fusion virus-cellule : données actuelles montrant le rôle des micro-domaines membranaires dans le cycle d’infection du VIH-1

    Directory of Open Access Journals (Sweden)

    Hammache Djilali

    2000-09-01

    Full Text Available Depuis plusieurs années, nous étudions les mécanismes moléculaires responsables de la fusion du virus de l’immunodéficience humaine (VIH avec la membrane plasmique des cellules cibles. Ces travaux ont permis de préciser le rôle essentiel joué par les micro-domaines de glycosphingolipides au cours de la fusion virus-cellule. En particulier, nous avons pu reconstituer un complexe de fusion fonctionnel faisant intervenir les différents partenaires moléculaires de la fusion : un micro-domaine de glycosphingolipide se présentant sous la forme d’un film monomoléculaire à l’interface eau-air, le récepteur CD4 et la glycoprotéine externe de l’enveloppe du virus, la gp120. La dynamique des interactions moléculaires dans ce complexe de fusion a pu être mesurée à l’aide d’un micro-tensiomètre. Ce système expérimental pourrait permettre d’évaluer l’activité d’inhibiteurs de fusion tels que des analogues synthétiques de glycosphingolipides.

  1. Annotation sémantique floue de tableaux guidée par une ontologie

    OpenAIRE

    Hignette, Gaëlle

    2007-01-01

    Nous pr´esentons dans ce m´emoire une m´ethode d'annotation de tableaux guid´ee par les connaissances d'un domaine d'application formalis´ees dans une on- tologie. Apr`es avoir pr´esent´e le contexte applicatif et une ´etude bibliographique sur l'annotation s´emantique et l'extraction d'information, nous pr´esentons les diff´erentes ´etapes de notre syst`eme : annotation des cellules, des colonnes puis des relations repr´esent´ees par le tableau. Nous traitons diff´eremment les donn´ees selon...

  2. Installation solaire de production hydrogène par l'électrolyse de vapeur d'eau

    OpenAIRE

    Miri, Rachid; Mraoui, Abdelhamid

    2007-01-01

    International audience Cette étude porte sur la conception d'une installation de production d'hydrogène par électrolyse de vapeur d'eau à hautes températures (700-1000°C) dont les ressources énergétiques sont solaires : l'alimentation en vapeur d'eau est assurée par une centrale solaire à concentration et le courant électrique est fourni par des cellules Photovoltaïques. La simulation numérique de la production d'hydrogène, pour l'installation proposée, est faite en se basant sur les équat...

  3. Facing the danger zone: the use of ultrasound to distinguish cellulitis from abscess in facial infections.

    Science.gov (United States)

    Lewis, Dywanda L; Butts, Christine J; Moreno-Walton, Lisa

    2014-01-01

    Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1) emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2) demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3) depict an instance where ultrasound detected an abscess when computed tomography (CT) scan did not. PMID:24851189

  4. Unilateral proptosis and orbital cellulitis in eight African hedgehogs (Atelerix albiventris).

    Science.gov (United States)

    Wheler, C L; Grahn, B H; Pocknell, A M

    2001-06-01

    Eight African hedgehogs (Atelerix albiventris) were presented with unilateral proptosis. Six animals presented specifically for an ocular problem, whereas two had concurrent neurologic disease. Enucleation and light microscopic examination of tissues was performed in five animals, and euthanasia followed by complete postmortem examination was performed in three animals. Histopathologic findings in all hedgehogs included orbital cellulitis, panophthalmitis, and corneal ulceration, with perforation in seven of eight eyes. The etiology of the orbital cellulitis was not determined, but it appeared to precede proptosis. Orbits in hedgehogs are shallow and the palpebral fissures are large, which may predispose them to proptosis, similar to brachycephalic dogs. This clinical presentation was seen in 15% (8/54) of African hedgehogs presented to the Western College of Veterinary Medicine over a 2-yr period from January 1995 to December 1996 and warrants further investigation. PMID:12790427

  5. Étude et réalisation d'une cellule solaire à colorant.

    OpenAIRE

    DEBBAB, Moustafa

    2014-01-01

    Dans ce travail on a réalisé une cellule solaire à colorant DSSC, utilisant comme semi-conducteur le TiO2 qui à un rôle important dans la cellule a qualité de transporteur d‟électrons. Nous utilisons aussi un colorant naturel à base d‟extrait de fraise ayant une valeur d‟absorbance de 0.546 V. Après avoir mis en évidence les problèmes qui se posaient dans l‟élaboration de l‟anode, nous avons varié différents paramètres pour fabriquer ce dernier, en effectuant des dépôts de c...

  6. Mycobacterium avium-intracellulare cellulitis occurring with septic arthritis after joint injection: a case report

    Directory of Open Access Journals (Sweden)

    Murdoch David M

    2007-02-01

    Full Text Available Abstract Background Cellulitis caused by Mycobacterium avium-intracellulare has rarely been described. Mycobacterium avium-intracellulare is a rare cause of septic arthritis after intra-articular injection, though the causative role of injection is difficult to ascertain in such cases. Case presentation A 57-year-old with rheumatoid arthritis treated with prednisone and azathioprine developed bilateral painful degenerative shoulder arthritis. After corticosteroid injections into both acromioclavicular joints, he developed bilateral cellulitis centered over the injection sites. Skin biopsy showed non-caseating granulomas, and culture grew Mycobacterium avium-intracellulare. Joint aspiration also revealed Mycobacterium avium-intracellulare infection. Conclusion Although rare, skin and joint infections caused by Mycobacterium avium-intracellulare should be considered in any immunocompromised host, particularly after intra-articular injection. Stains for acid-fast bacilli may be negative in pathologic samples even in the presence of infection; cultures of tissue specimens should always be obtained.

  7. A case of dissecting cellulitis and a review of the literature.

    Science.gov (United States)

    Scheinfeld, Noah S

    2003-02-01

    Dissecting cellulitis (also called perifolliculitis capitis abscedens et suffodiens) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. It predominantly occurs in African American men between 20-40 years of age, but can occasionally affect other races and women too. Associated musculoskeletal findings are sometimes reported. When it occurs with acne conglobata, hidradenitis suppurativa, and pilonidal cysts, the syndrome is referred to as the follicular occlusion triad or tetrad. Its course is chronic and relapsing, and treatment is often difficult. Medical therapies include isotretinoin, antibiotics, and prednisone. Destructive therapies include X-ray therapy, surgical excision, and skin grafting. Laser epilation of hair follicles is a promising new therapy for dissecting cellulitis. PMID:12639466

  8. Facing the Danger Zone: The Use of Ultrasound to Distinguish Cellulitis from Abscess in Facial Infections

    Directory of Open Access Journals (Sweden)

    Dywanda L. Lewis

    2014-01-01

    Full Text Available Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1 emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2 demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3 depict an instance where ultrasound detected an abscess when computed tomography (CT scan did not.

  9. Radionuclide imaging in early detection of childhood osteomyelitis and its differentiation from cellulitis and bone infarction

    International Nuclear Information System (INIS)

    In children, radionuclide skeletal imaging with sup(99m)Tc-phosphate compounds is significantly more sensitive than roentgenographic studies in the early detection of osteomyelitis and septic arthritis. The scintigraphic patterns are usually characteristic. Cellulitis and some cases of early infarction are easily differentiated from osteomyelitis. However, some cases of infarction are indistinguishable from osteomyelitis on sup(99m)Tc-phosphate scan. In these cases 67Ga-citrate may prove helpful

  10. Insufficiency fractures of the distal tibia misdiagnosed as cellulitis in three patients with rheumatoid arthritis

    International Nuclear Information System (INIS)

    We describe 3 patients with rheumatoid arthritis who presented with diffuse pain, swelling, and erythema of the distal aspect of the lower extremity, suggestive of either cellulitis or thrombophlebitis, but were found to have insufficiency fractures of the distal tibia. The value of technetium-99m diphosphonate bone scintigraphy in the early recognition of these fractures and a possible explanation for the associated inflammatory symptoms are discussed

  11. Prevalence and Epidemiological Factors Involved in Cellulitis in Korean Patients With Lymphedema

    OpenAIRE

    Park, Sae In; Yang, Eun Joo; Kim, Dong Kyu; Jeong, Ho Joong; Kim, Ghi Chan; Sim, Young-Joo

    2016-01-01

    Objective To evaluate the prevalence and associated factors involved in cellulitis with lymphangitis among a group of Korean patients who were being treated for lymphedema. We present our epidemiologic research and we also report a systematic review of these types of cases. Methods This was a retrospective medical record study among 1,246 patients diagnosed with lymphedema. The study was carried out between January 2006 and December 2012 at the Kosin University Gospel Hospital and Seoul Natio...

  12. A Woman with Unilateral Rash and Fever: Cellulitis in the Setting of Lymphedema

    Directory of Open Access Journals (Sweden)

    Melissa Joseph

    2015-01-01

    Full Text Available Cellulitis in the setting of lymphedema is an uncommon but clinically important presentation to the emergency department. Stagnant lymph is an ideal medium for bacterial growth and progression can be rapid due to decreased ability to fight infection in the affected area. Infections are commonly caused by gram-positive cocci, though blood cultures are often negative. Treatment should be aimed at rapid initiation of antibiotics targeting these species. There may be a role for antibiotic prophylaxis in recurrent cases.

  13. Caratterizzazione di batteri pigmentati e studio degli effetti di molecole batteriche e vegetali su cellule umane

    OpenAIRE

    Manzo, Nicola

    2013-01-01

    Il lavoro svolto durante questi tre anni di Dottorato è raccolto in questa Tesi ed è suddiviso in quattro capitoli distinti. Due capitoli sono dedicati alla caratterizzazione di bacilli produttori di carotenoidi, uno all'interazione tra il batterio lattico Lactobacillus gasseri e cellule dell'epitelio intestinale umano ed uno agli effetti di un estratto della pianta Aloe arborescens su diverse linee cellulari umane. Tali argomenti, anche se apparentemente indipendenti, sono invece strettam...

  14. A Rare Case of Orbital Cellulitis Followed by Therapeutic(Orthodontic) Extraction

    OpenAIRE

    Srinivasa Prasad, B.; Govardhan, T.

    2011-01-01

    We report a rare case of orbital cellulitis occurring secondary to a dental infection followed by therapeutic (orthodontic) extraction. A 16 year old female patient presented to the dental office with a left orbital proptosis for the past 4 days. PNS view, CT scan revealed an abscess in relation to medial, lateral superior inferior walls of the orbit associated with naso ethmoidal and left maxillary sinus. Through nasal endoscopy, middle meatus antrostomy and ethmoidectomy was performed for t...

  15. Pseudomonas aeruginosa bacteremia secondary to acute right leg cellulitis: case of community-acquired infection

    OpenAIRE

    Wahab, Asrul Abdul; Rahman, M.M.

    2013-01-01

    Pseudomonas aeruginosa is a gram-negative bacillus that causes wide spectrum clinical infections. However, it is most frequently associated with hospital-acquired infection. In this case a 58-year-old male with underlying hypertension and dyslipidaemia was admitted for acute right leg cellulitis. Pseudomonas aeruginosa was identified from the case, though it was not a usual suspected organism. It might be due to community-acquired infection.

  16. Phalangeal fractures and metacarpophalangeal luxations subsequent to post-traumatic osteomyelitis and cellulitis in a dog.

    Science.gov (United States)

    Langley-Hobbs, S J; Lascelles, B D X

    2004-07-01

    A working Border collie suffered a puncture wound to the metacarpal pad. No fractures or luxations were identified at initial presentation. Treatment was instigated with various antibacterials for a period of months. At subsequent visits, the dog's condition progressed with development of metacarpophalangeal joint luxation and phalangeal fractures secondary to cellulitis and chronic osteomyelitis. Amputation was curative. Prompt treatment of the acute condition with debridement and drainage may have prevented osteomyelitis becoming established in the first instance. PMID:15266860

  17. Infratemporal fossa cellulitis caused by a remnant iatrogenic foreign body after a bimaxillary operation.

    Science.gov (United States)

    Park, Do Yang; Choo, Oak-Sung; Hong, Sang Young; Kim, Hyun Jun

    2015-05-01

    Infratemporal fossa cellulitis is rare and mostly occurs because of sinusitis and dental procedures. Furthermore, cellulitis caused by iatrogenic foreign bodies is very rare. A 28-year-old woman who had previously undergone cosmetic bimaxillary operation visited our hospital complaining of left facial swelling, oppressive pain, and nasal obstruction since 2 years. She had been attending another clinic, but despite having additional procedures and taking medications, her symptoms persisted. A subsequent operation was performed, during which we found a remnant surgical gauze from the previous operation, which was decomposed and trapped around the necrotic soft tissue and had eroded the bony structure around the pterygoid fossa. The material was successfully removed by endoscopic surgery, and the necrotic tissue was debrided. After the operation, all symptoms disappeared, and the patient was discharged without sequelae. During any procedure, surgeons must meticulously check for remnant material. Additionally, physicians must carefully note patient history and perform a physical examination, even in patients without serious symptoms. We report a case of advanced infratemporal fossa cellulitis due to remnant gauze material during a previous operation that was undetected. PMID:25950522

  18. [Cervico-facial cellulitis during pregnancy: about a series of 10 cases in Mali].

    Science.gov (United States)

    Doumbia-Singare, K; Timbo, S K; Keita, M; Ag Mohamed, A; Guindo, B; Soumaoro, S

    2014-12-01

    The objective of this work was to analyze the predisposing factors, diagnostic and therapeutic aspects of cervico-facial cellulitis on pregnancies and to determine maternal-fetal prognosis. We conducted a longitudinal observational descriptive study from January 2011 to March 2013 including records from pregnant women with cervicofacial cellulitis treated at the Oto-Rhino-Laryngology (ORL) and cervico-facial surgery department at Gabriel Touré Hospital in Bamako. Ten women met our inclusion criteria. The median age was 23 years. The entry way was dental in all cases. Three women had taken antibiotics and 3 others antibiotics associated with non steroidal anti-inflammatory. The medico-surgical treatment had permitted to cure 8 cases. Two cases of death were recorded and 4 cases of stillbirths. The cervico-facial cellulitis during pregnancy is a serious pathology that can be life-threatening to the mother and or child. Prevention is based on the control of dental status and informing women about the importance of dental hygiene. PMID:25304000

  19. European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate

    Directory of Open Access Journals (Sweden)

    Tsironi Evangelia E

    2012-05-01

    Full Text Available Abstract Background Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed description of a community-associated methicillin-resistant S. aureus ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial acquisition and treatment selection are also discussed. Case presentation A 28-day-old Caucasian boy was referred to our hospital with the diagnosis of right orbital cellulitis. His symptoms included right eye proptosis, periocular edema and redness. Empirical therapy of intravenous daptomycin, rifampin and ceftriaxone was initiated. The culture of pus yielded a methicillin-resistant S. aureus isolate and the molecular analysis revealed that it was a Panton-Valentine leukocidine-positive ST80 strain. The combination antimicrobial therapy was continued for 42days and the infection was successfully controlled. Conclusions Clinicians should be aware that young infants, even without any predisposing condition, are susceptible to orbital cellulitis caused by community-associated methicillin-resistant S. aureus. Prompt initiation of the appropriate empirical therapy, according to the local epidemiology, should successfully address the infection, preventing ocular and systemic complications.

  20. Par Pond water balance

    International Nuclear Information System (INIS)

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  1. Contribution à la clarification du régime juridique de la responsabilité de l’Etat résultant d’un placement en cellule de dégrisement

    OpenAIRE

    Edouard, Thierry

    2014-01-01

    Le 7 janvier 2011, les gendarmes du village de Camopi (Guyane française) étaient requis par une jeune femme se plaignant de violences conjugales. Le fauteur, M. A., finalement interpellé dans la soirée, est conduit à la brigade territoriale. Son état d’ébriété manifeste justifiait qu’il soit placé en cellule de dégrisement, dans l’attente d'une garde à vue. Au petit matin, l’époux violent est retrouvé sans vie, pendu au cordon de son calimbé. Au-delà du relatif retentissement médiatique, cett...

  2. INSULIN INDUCES NITRIC OXIDE PRODUCTION IN BOVINE AORTIC ENDOTHELIAL CELLS

    Institute of Scientific and Technical Information of China (English)

    李慧丽; 黄定九

    2000-01-01

    ffeStun6. ObjeCtif Dens cette dtude nons avons ewilue l' effet de l' insuline sur ba Proliferation cellulaire, liberationd' oxide nitrique et l' expression gdrktique de synthase d' oxide nitrique dens la cellule endotheliale aortique bovine. methIn mitogdthe est evalude per la ndthae M7T. In Production de NO dans ie alga en culture est determine per la reactionGness. In technique quantitative RT/PCR est utility pour quantifier ie niveau de sWthase d' oxide nitrique mRNA dens la cellule endotheliale aortique...

  3. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Soma Mukherjee

    2013-01-01

    Full Text Available Ludwig′s angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregnancy, lest life-threatening complications like Ludwig′s angina occur, complicating the course of pregnancy.

  4. Amelioration_du_Rendement_Energetique_de_Cellules_Photovoltaïques_en_Couches_Minces_a_base_de_CZTS.

    OpenAIRE

    BOUDJERAD_epouse_MEGHNINE, Fatiha

    2014-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de CuZnSnS4 (CZTS) semble prometteur. En effet, le rendement de ces cellules a dépassé les 30% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logic...

  5. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  6. Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis

    Directory of Open Access Journals (Sweden)

    Giuseppe Valacchi

    2015-08-01

    Full Text Available Objectives: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. Material and Methods: We used the emergency department (ED visits data in Edmonton, Canada for the period from 1992 (April to 2002 (March. We retrieved all the diagnosed ED visits for cellulitis and pharyngitis. Case-crossover design was used to study potential association between ozone and those visits. Conditional logistic regression was used to estimate odds ratios (OR and their 95% confidence intervals (95% CI. Results: The results are reported for the interquartile range (IQR = 17.9 ppb for 8 h maximum ozone. Positive and statistical significant results were obtained as follows: for lags from 0 to 3 (OR = 1.07, 95% CI: 1.03–1.12, lag 2; for lags from 0 to 6 days (OR = 1.08, 95% CI: 1.03–1.12, lag 3; for lags from 0 to 4 (OR = 1.06, 95% CI: 1.03–1.09, for lag 2 and 3. Conclusions: The findings suggest the response to exposure to ambient ground-level ozone for skin and pharyngitis considered separately and jointly.

  7. A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.

    LENUS (Irish Health Repository)

    Quirke, M

    2014-11-01

    To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-referral, symptom duration of more than 48 hours and absence of pre-EO antibiotic therapy.

  8. Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis

    Directory of Open Access Journals (Sweden)

    Rebecca Sin Mei Lim

    2013-01-01

    Full Text Available We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.

  9. Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases

    Directory of Open Access Journals (Sweden)

    Souleymane Brah

    2011-01-01

    Full Text Available Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. We describe three cases of severe infection due to C. fetus with cellulitis at presentation, but without any gastrointestinal symptoms, occurring in patients with acquired hypogammaglobulinemia.

  10. Production de biohydrogène par électro-catalyse microbienne

    OpenAIRE

    Rousseau, Raphaël

    2013-01-01

    La cellule d’électrolyse microbienne (CEM) permet la conversion de la biomasse en dihydrogène via un apport théorique en énergie électrique 10 fois moindre que celui de l’électrolyse de l’eau. Un tel procédé fonctionne via la technologie des bioanodes, qui permet la catalyse de l’oxydation de la biomasse en CO2 par l’intermédiaire d’un biofilm électro-actif. Les travaux exposés dans ce manuscrit de thèse ont pour but l’optimisation des performances de la bioanode, la compréhension des mécanis...

  11. ViPAR

    DEFF Research Database (Denmark)

    Carter, Kim W; Francis, Richard W; Bresnahan, M; Gissler, M; Grønborg, T K; Gross, R; Gunnes, N; Hammond, G; Hornig, M; Hultman, C M; Huttunen, J; Langridge, A; Leonard, H; Newman, S; Parner, E T; Petersson, G; Reichenberg, A; Sandin, S; Schendel, Diana; Schalkwyk, L; Sourander, A; Steadman, C; Stoltenberg, C; Suominen, A; Surén, P; Susser, E; Sylvester Vethanayagam, A; Yusof, Z

    2015-01-01

    free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations. METHODS: Database federation permits controlled access to remotely located datasets from a central location. The Secure Shell protocol allows data to be securely exchanged......PAR infrastructure, remote sites manage their own harmonized research dataset in a database hosted at their site, while a central server hosts the data federation component and a secure analysis portal. When an analysis is initiated, requested data are retrieved from each remote site and virtually pooled at the...... central site. The data are then analysed by statistical software and, on completion, results of the analysis are returned to the user and the virtually pooled data are removed from memory. CONCLUSIONS: ViPAR is a secure, flexible and powerful analysis platform built on open source technology that is...

  12. Facial and Periorbital Cellulitis due to Skin Peeling with Jet Stream by an Unauthorized Person

    Directory of Open Access Journals (Sweden)

    Asli Feride Kaptanoglu

    2014-01-01

    Full Text Available Technologies and devices for cosmetic procedures are developing with each passing day. However, increased and unauthorized use of such emerging technologies may also lead to increases in unexpected results and complications as well. Here, we report a case of facial cellulitis after a “beauty parlor” session of skin cleaning with jet stream peeling device in 19-year old female patient for the first time. Complications due to improper and unauthorized use of jet stream peeling devices may also cause doubts about the safety and impair the reputation of the technology as well. In order to avoid irreversible complications, local authorities should follow the technology and update the regulations where the dermatologists should take an active role.

  13. 眼外伤致眶蜂窝组织炎的护理%Nursing of Oribital Cellulitis Caused by Eye Injury

    Institute of Scientific and Technical Information of China (English)

    林丽萍; 胡淑英; 陈少娜

    2002-01-01

    To sum up 20 cases of nursing Oribital cellulitis caused by eye injury and suggest that it is important fornursing to pay close attention to patient's condition, to prevent cross infection and psychological nursing and to publicizehygiene element knowledge.

  14. Computed tomographic patterns of orbital cellulitis due to sinusitis Padrões tomográficos de celulite orbitária secundária à sinusite

    OpenAIRE

    Filipe José Pereira; Antonio Augusto Velasco e Cruz; Wilma Teresinha Anselmo-Lima; Jorge Elias Júnior

    2006-01-01

    PURPOSE: To describe the CT findings of orbital cellulitis due to sinusitis. METHODS: The records and CT scans of 45 consecutive patients with orbital cellulitis due to sinusitis treated at the Hospital of the Medical School of Ribeirão Preto were analyzed by a radiologist and two orbital surgeons. RESULTS: Three major types of CT changes were observed: diffuse fat infiltration, subperiosteal abscess and orbital abscess. Diffuse fat infiltration (characterized by an increased density of the e...

  15. Carcinoma a cellule basali: l'esperienza della dermatologia dell'Universita' di Bologna dal 1990 al 2014

    OpenAIRE

    Gaspari, Valeria

    2015-01-01

    Il carcinoma a cellule basali (BCC) costituisce l'80 peercento dei tumori cutanei non-melanoma, rappresentando dunque il tumore maligno della cute più frequente nella popolazione generale. Tuttavia, non esistono ad oggi studi epidemiologici ampi ed approfonditi condotti su scala nazionale su questo tipo di neoplasia, poichè i tumori cutanei non-melanoma sono esclusi dal registro statistico dei tumori. A tale scopo presso la Dermatologia dell'Università di Bologna sono stati raccolti di tut...

  16. Juvenile cellulitis in a puppy – case reports
    Celulite juvenil canina – relato de casos

    OpenAIRE

    Carlos Eduardo Fonseca-Alves; Aline Gonçalves Correa; Hérika Xavier da Costa; Fabiana Elias; Helvécio Leal Santos Junior; Sabrina dos Santos Costa; Sabryna Gouveia Calazans

    2012-01-01

    Juvenile cellulitis or juvenile sterile granulomatous lymphadenitis is a rare disorder that affects puppies between three weeks to six months years old. Clinical signs include alopecia, edema, papules, pustules and crusts especially on eyelids. Definitive diagnosis requires cytological and histological evaluation and early and aggressive therapy is recommended, once scars after recovery can be severe .The choice treatment is the high dose of corticosteroids use such as prednisone. Three anima...

  17. Eduquer par la musique

    OpenAIRE

    Zhe, Ji

    2011-01-01

    La politique et l’éducation sont indissociables dans les tentatives de promouvoir le confucianisme en Chine contemporaine. L’union alors célébrée du sacré, du pouvoir et du savoir s’inscrit en tension avec une modernité d’abord caractérisée par la différenciation des institutions et des valeurs. Partant de ce constat, l’article étudie le cas particulier d’une société engagée depuis 2000 dans l’initiation des enfants à la musique classique et dans la promotion de la « culture de soi » chez les...

  18. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    Directory of Open Access Journals (Sweden)

    Juan S. Lasa

    2012-08-01

    Full Text Available La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB. Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celulitis. Se analizaron retrospectivamente los registros clínicos de los pacientes con este diagnóstico al ingreso entre junio de 2007 y marzo de 2010. Se evaluaron los datos poblacionales, presencia de comorbilidades, y resultados de los cultivos. En ese período, se internaron 140 pacientes con diagnóstico de celulitis y a todos ellos se les realizó hemocultivo y cultivos de PPB. Setenta y cuatro eran varones (52.8%. La edad promedio: 47.5 ± 19.7 años (rango 16-94. El 40% tuvo cultivos positivos de PPB, en los que el Staphylococcus aureus meticilino resistente (SAMR fue el germen más frecuentemente aislado (35.7%; la prevalencia de bacteriemia fue del 8.6%, en donde el germen más frecuente fue Streptoccocus Beta hemolítico, grupo G (33% del total de hemocultivos positivos. La bacteriemia se asoció significativamente a mayor estadía hospitalaria (10.5 ± 8.9 vs. 4.9 ± 6, p = 0.004. Se asoció con mayor riesgo de hemocultivo positivo a ser diabético, tener cultivo de PPB positivo, consumo de alcohol y/o enfermedad pulmonar obstructiva crónica.Cellulitis is an acute inflammation of dermis and subcutaneous tissue, usually complicating wounds, ulcers, or dermatosis. Even though in these cases it is recommended to perform culture from skin and soft tissue samples, the utility of blood cultures remains controversial due to the low frequency of positive results. Here we report the prevalence of bacteremia in patients with cellulitis admitted in our

  19. Juvenile cellulitis in a puppy – case reportsCelulite juvenil canina – relato de casos

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Fonseca-Alves

    2012-08-01

    Full Text Available Juvenile cellulitis or juvenile sterile granulomatous lymphadenitis is a rare disorder that affects puppies between three weeks to six months years old. Clinical signs include alopecia, edema, papules, pustules and crusts especially on eyelids. Definitive diagnosis requires cytological and histological evaluation and early and aggressive therapy is recommended, once scars after recovery can be severe .The choice treatment is the high dose of corticosteroids use such as prednisone. Three animals of canine species were attended at the Veterinary Hospital Clinical Small Animal Service presenting different clinical signs. Hemogram, skin lesions and submandibular lymph nodes cytological examination was collected and analyzed. The treatment was instituted, using cephalexin (22mg/kg, twice daily up to control of secondary bacterial infection, and prednisone (2mg/kg, once a day until clinical resolution. Complete cure was obtained at the end of treatment. The aim of this work is to report three clinical cases of juvenile cellulitis in dogs. A celulite juvenil ou linfadenite granulomatosa estéril juvenil, é um distúrbio raro que acomete filhotes com idade entre três semanas a seis meses. Os sinais clínicos incluem alopecia, edema, pápulas, pústulas e crostas especialmente em pálpebras. O diagnóstico definitivo requer exames citológico e histopatológico e a terapia precoce e agressiva é preconizada, pois as cicatrizes após recuperação podem ser graves. O tratamento de escolha consiste no uso de altas doses dos glicocorticoides, como prednisona. Foram atendidos no Hospital Veterinário, três animais da espécie canina, apresentando sinais clínicos variados. Foram realizados hemograma, exame citológico das lesões de pele e dos linfonodos submandibulares. O tratamento foi instituído, utilizando-se cefalexina na dose de 22 mg/kg, duas vezes ao dia, até controle de infecção bacteriana secundária e prednisona na dose de 2mg/kg, uma vez

  20. Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report

    Directory of Open Access Journals (Sweden)

    Probst Corina

    2010-08-01

    Full Text Available Abstract Background Cryptococcus neoformans is an encapsulated yeast and the most frequent cryptococcal species found in humans. Cryptococcosis is considered an opportunistic infection as it affects mainly immunosuppressed individuals. In humans, C. neoformans causes three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and wound or cutaneous cryptococcosis. Case Presentation An 81-year-old woman developed severe necrotizing cellulitis on her left arm without any preceding injury. The patient had been treated with systemic corticosteroids over twenty years for rheumatoid arthritis (RA. Skin biopsies of the wound area were initially interpreted as cutaneous vasculitis of unknown etiology. However, periodic acid Schiff staining and smear analysis later revealed structures consistent with Cryptococcus neoformans, and the infection was subsequently confirmed by culture. After the initiation of therapy with fluconazole 400 mg per day the general condition and the skin ulcers improved rapidly and the patient was discharged to a rehabilitation facility. Subsequently surgical debridement and skin grafting were performed. Conclusions Opportunistic infections such as cryptococcosis can clinically and histologically mimic cutaneous vasculitis and have to be investigated rigorously as a differential diagnosis in immunosuppressed patients.

  1. Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.

    Science.gov (United States)

    Hau, Estelle; Bouaziz, Jean-David; Lafaurie, Matthieu; Saussine, Anne; Masson, Vincent; Rausky, Jonathan; Bagot, Martine; Guibal, Fabien

    2016-03-01

    Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement. PMID:27023094

  2. A rare case of orbital cellulitis followed by therapeutic(orthodontic) extraction.

    Science.gov (United States)

    Srinivasa Prasad, B; Govardhan, T

    2011-09-01

    We report a rare case of orbital cellulitis occurring secondary to a dental infection followed by therapeutic (orthodontic) extraction. A 16 year old female patient presented to the dental office with a left orbital proptosis for the past 4 days. PNS view, CT scan revealed an abscess in relation to medial, lateral superior inferior walls of the orbit associated with naso ethmoidal and left maxillary sinus. Through nasal endoscopy, middle meatus antrostomy and ethmoidectomy was performed for the drainage of pus from the orbit, ethmoid and maxillary sinus under general anesthesia. Immediately regression of orbital swelling was noticed. Eyeball movements improved. Epiphora reduced and proptosis declined. With the advent of higher antibiotics, orbital infection rarely occurs secondary to dental causes except in a very few cases. Complete elimination of pus from orbital cavity, para nasal air sinuses and appropriate antibiotic coverage at the earliest forms the mainstay of treatment. The nasal endoscopic approach with orbital decompression is the most acceptable atrumatic, cosmetic and functional procedure. PMID:22942598

  3. A case of cellulitis of the hands caused by a predatory bird attack

    Institute of Scientific and Technical Information of China (English)

    M Adil Abbas Khan; Mohammed Farid; Zain A Sobani; Syed Nadir Ali; Huzaifa Malick; Maryam Baqir; Hasanat Sharif; M Asim Beg

    2011-01-01

    Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  4. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  5. Datation par thermoluminescence

    Directory of Open Access Journals (Sweden)

    1976-01-01

    Full Text Available Depuis 1953, de nombreux chercheurs se sont intéressés à la datation par thermoluminescence de minéraux anciennement brûlés ou cuits. Dans ce travail, après avoir rappelé quelques principes physiques de la thermoluminescence, on présente cette méthode de datation en mettant l'accent sur le mécanisme thermoluminescent dans une poterie. Ainsi la dose d'irradiation reçue par le matériau étant proportionnelle au temps écoulé depuis le 'zéro archéologique', il est possible de déterminer 'la dose archéologique' et d'en déduire l'âge de l'échantillon après avoir calculé la dose d'irradiation annuelle. La réalisation pratique d'un tel ensemble de mesure est cependant très ardue. Dans un prochain article, E. A. Decamps et A. Roman montreront des résultats relatifs à la thermoluminescence d'échantillons de quartz naturels, purs et dopés et la mise au point d'une nouvelle méthode de datation. Desde 1953, muchos investigadores se han interesado en la datación por termoluminiscencia de minerales antiguamente quemados o cocidos. Dentro de este trabajo, luego de haber recordado algunos principios físicos de la termoluminiscencia, se presenta este método de datación poniendo mayor atención en el mecanismo termoluminescente en una vasija de metal o de barro. Siendo proporcional la dosis de irradiación recibida al tiempo transcurrido desde el 'cero arqueológico', es posible determinar 'la dosis arqueológica', y deducir la edad de la muestra luego de haber calculado la dosis de irradiación anual. La realización práctica de un trabajo de tal dimensión es sin embargo muy ardua. En un próximo artículo, E. A. Decamps y A. Román presentarán los resultados relativos a la termoluminiscencia de muestras de cuarzo naturales, puras y dopadas y la elaboración de un nuevo método de datación. Since 1953, a number of scientists have been concerned with the use of thermoluminescence for the dating of burned or fired minerals

  6. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  7. Immunopathogenic Background of Pars Planitis.

    Science.gov (United States)

    Przeździecka-Dołyk, Joanna; Węgrzyn, Agnieszka; Turno-Kręcicka, Anna; Misiuk-Hojło, Marta

    2016-04-01

    Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The incidence of pars planitis varies 2.4-15.4 % of the uveitis patients. The pathogenesis of the disease is to be determined in future. Clinical and histopathological findings suggest an autoimmune etiology, most likely as a reaction to endogenous antigen of unknown source, with T cells predominant in both vitreous and pars plana infiltrations. T cells subsets play an important role as a memory-effector peripheral cell. Snowbanks are formed as an effect of post inflammatory glial proliferation of fibrous astrocytes. There is also a genetic predisposition for pars planitis by human leukocyte antigen and several other genes. A coexistence of multiple sclerosis and optic neuritis has been described in numerous studies. Epiretinal membrane, cataract, cystoid macular edema, retinal detachment, retinal vasculitis, neovascularization, vitreous peripheral traction, peripheral hole formation, vitreous hemorrhage, disc edema are common complications observed in pars planitis. There is a need to expand the knowledge of the pathogenic and immunologic background of the pars planitis to create an accurate pharmacological treatment. PMID:26438050

  8. Implications and applications of systematic reviews for evidence-based dentistry and comparative effectiveness research: A sample study on antibiotics for oro-facial cellulitis treatment

    Directory of Open Access Journals (Sweden)

    Quyen Bach

    2015-01-01

    Full Text Available Introduction: Comparative effectiveness and efficacy research for analysis and practice (CEERAP was performed to assess the effects of penicillin-based versus erythromycin-based antibiotic treatments in patients with skin and soft tissue infections (SSTIs including cellulitis, impetigo, and erysipelas. Because SSTIs, especially orofacial cellulitis, are volatile infectious diseases of a life-threatening nature, research on the most efficacious remedies is necessary. Methods: The stringent bibliome yielded three systematic reviews, which were examined for quality of research synthesis protocol and clinical relevance. Results: The sample size of three, rendered the statistical analyses and cumulative meta-analysis problematic. Conclusion: The systematic review outlined here should aid in increasing clinical awareness, improving patient health literacy, and promoting consensus of the best evidence base (BEB to mitigate the threat of sepsis and potential death caused by cellulitis infections.

  9. Cassures double-brin de l'ADN, cassures chrosomiques et létalité des cellules humaines irradiées

    Science.gov (United States)

    Foray, N.; Arlett, C. F.; Malaise, E. P.

    1998-04-01

    DNA double-strand breaks (DSB) are the likely event which may explain the radiation-induced killing effect in mammalian cells. An overview of the litterature shows that, to the exception of a small group of human tumours, the repair defect rather than the induction rate of DSB plays the major role. However, the arguments supporting the relationship between DSB and intrinsic radiosensitivity are most often indirect. Our results dealing with intrinsic radiosensitivity, residual DNA DSB and chromosome breaks have been achieved with untransformed human fibroblasts (5 control and 18 hypersensitive cell lines). We describe a quantitative relationship between the intrinsic radiosensitivity and the residual breaks. The death of a human fibroblast is linked to 1.3 unrepaired chromosome break and 6.6 unrepaired DSB. Les cassures double-brin (CDB) de l'ADN constituent l'événement-clé susceptible d'expliquer l'effet létal des radiations ionisantes. Une revue générale de la littérature montre que, à l'exception d'un groupe minoritaire de tumeurs humaines, c'est surtout une déficience de réparation plutôt que l'incidence des dégâts qui est associée à la mort des cellules de mammifères irradiées. Toutefois, les arguments en faveur d'un lien entre radiosensibilité et CDB sont généralement indirects. À partir de 23lignées fibroblastiques humaines (5témoins et 18hypersensibles), nous décrivons une relation quantifiée entre la radiosensibilité intrinsèque et les cassures résiduelles de l'ADN et des chromosomes. La mort d'un fibroblaste humain irradié est associée à 6,6 CDB et 1,3 cassure chromosomique non réparées.

  10. suPAR: the molecular crystal ball

    DEFF Research Database (Denmark)

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences...... inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions....

  11. Tumeur à cellules géantes du fémur proximal traitée par arthroplastie totale de hanche

    Science.gov (United States)

    Mhammdi, Younes; Kharmaz, Mohamed

    2016-01-01

    The authors report the case of a giant cell tumor grade 1 of the proximal femur, diagnosed in a young patient of 18 years. The diagnosis was suspected on a standard x-ray complemented by MRI, it was confirmed on histological examination after biopsy. The tumor was a metaphyseal-epiphyseal location above the level of the femoral cut on preoperative planning. The management had combined two surgical techniques, with a marginal resection of the femoral head and neck, and femoral curettage-filling of the metaphyseal region with implantation of a total cemented hip prosthesis. After 2 years of follow up, the result is very satisfactory with good functional recovery and no signs of recurrence. PMID:27279937

  12. Realisation and characterization of organic photovoltaic cells obtained by physical vapor deposition; Realisation et caracterisation de cellules photovoltaiques organiques obtenues par depot physique

    Energy Technology Data Exchange (ETDEWEB)

    Brousse, B.

    2004-12-01

    This work deals with the synthesis and the characterization of low cost organic solar cells, contributing to the development of renewable energies, and able to feed devices as portable telephone...In particular, we have contributed to the development of an experimentation bench for the obtention of different structures (bilayers, interpenetrated and multilayers) of solar cells from different donor-acceptor couples of small molecules. After having presented a retrospective of the physical phenomena and of the mechanisms involved, as well as those of the photovoltaic principle in the organic materials, we describe the technological steps allowing to carry out the solar cells. The materials (organic and metallic) are deposited on thin films (of 30 to 100 nm) spin-coating (PEDOT-PSS) or by vacuum evaporation (small molecules and metallization of the cathode) on a glass substrate covered by a conducting and a semi-transparent ITO layer constituting the anode. The structures carried out have been characterized in air in obscurity and under illumination by curves I(V), by capacitive measurements and IPCE spectra (photocurrent spectra). Different donor-acceptor couples (phthalocyanine/C60, oligomer of thiophene/C60 and phthalocyanine/perylene derivative) have been tested by various configurations: p-n heterojunctions distributed or not in the volume. The obtained results are better for the bilayers structures on account of the granularity of the C60. This characteristics have allowed us to carry out an efficient multilayer structure (CuPc/C60). In order to resolve the problem of the deposit of the C60, we have tested another acceptor molecule: a derived compound of the perylene (PPTC). Complementary studies have been carried out by the ionic implantation of the active layers, allowing both a densification and a doping of these ones; the encapsulation of the compounds by polyimide VDP (gaseous phase polymerization) have been evaluated. With this technique, we have developed too an alternative auto-protected structure. (O.M.)

  13. Effets thérapeutiques des cellules T regulatrices induitent par TGF-β sur l’autoimmunité et l’inflammation préétablies

    OpenAIRE

    Zheng, Song Guo

    2011-01-01

    Recent studies revealed that nTregs has less therapeutic effects on established autoimmune diseases. Current study asks if iTregs induced ex-vivo with TGF- can treat the established autoimmune diseases. In allergic asthma we observed that adoptive transfer of iTreg significantly suppressed airway and peri-vascular inflammation, reduced airway résistance, eosinophil recruitment, mucus hyper-production, airway remodeling and IgE levels. This therapeutic effect was associated with increase of Tr...

  14. Treatment of radioinduced skin burns by adult stem cells;Traitement des brulures cutanees radio-induites par cellules souches adultes

    Energy Technology Data Exchange (ETDEWEB)

    Lataillade, J.J.; Prat, M. [Hopital Militaire Percy, Centre de Transfusion Sanguine des Armees, Dept. Recherches et Therapies Cellulaires, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Bey, E. [Hopital Militaire Percy, Service de Chirurgie Plastique, 92 - Clamart (France)

    2009-12-15

    In the area of skin injuries caused by ionizing radiations; the recent opportunity give us the the possibility to manage victims of radiation accidents with skin acute symptoms of irradiation. The approach of cell therapy developed for these patients could be in a second time, used for other types of injuries as thermal burns and the injuries linked to overexposure in radiotherapy. In spite of the diversity of approaches of allogeneic and autologous transplantation, the prognosis of deep and extended radioinduced burns is not completely satisfying because of inflammatory recurrences, origin of graft failures. The stem cells have been used in association. The stem cells were got from sampling of autologous bone marrow after an expansion in vitro from 15 to 17 days. The cultures were realised in medium with 8% of platelet lysate (clinical grade). The cells have been given by injection in complement of epidermis auto graft. A spectacular effect was noticed the day after the injection, but disappearing in some days encouraging to realize supplementary injections. An effect of the quickness and the quality of the graft success is appeared significant too. no necrosis recurrence for the patients after four years for the first one of them. We think that the stem cells participate to the local control of inflammation. (N.C.)

  15. ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes

    OpenAIRE

    Lioy, Virginia S.; Andrea Volante; Nora E Soberón; Rudi Lurz; Silvia Ayora; Alonso, Juan C.

    2015-01-01

    In Firmicutes, small homodimeric ParA-like (δ2) and ParB-like (ω2) proteins, in concert with cis-acting plasmid-borne parS and the host chromosome, secure stable plasmid inheritance in a growing bacterial population. This study shows that (ω:YFP)2 binding to parS facilitates plasmid clustering in the cytosol. (δ:GFP)2 requires ATP binding but not hydrolysis to localize onto the cell's nucleoid as a fluorescent cloud. The interaction of (δ:CFP)2 or δ2 bound to the nucleoid with (ω:YFP)2 foci f...

  16. Designing Tone Reservation PAR Reduction

    Directory of Open Access Journals (Sweden)

    Johansson Albin

    2006-01-01

    Full Text Available Tone reservation peak-to-average (PAR ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.

  17. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  18. Calcul de la Puissance Acoustique Rayonnée par les Parois d'un Bâtiment vers Le Milieu Extérieur

    OpenAIRE

    Simoneau, Thierry

    2010-01-01

    L'application du principe de conservation de l'énergie acoustique réverbérée et de l'hypothèse de diffusion homogène permet d'établir un modèle de calcul à la fois simple, original, flexible et robuste de la puissance acoustique rayonnée par les parois d'un bâtiment de géométrie quelconque vers le milieu extérieur. Ce modèle consiste dans un premier temps à décomposer le bâtiment et ses locaux en cellules de dimensions équivalentes et à appliquer la théorie des couplages en régime stationnair...

  19. Contribution à l'étude des perturbations électromagnétiques générées par des convertisseurs

    OpenAIRE

    Lardellier, Maurice

    1996-01-01

    Ce travail présente une nouvelle méthode de détermination des perturbations conduites générées par les convertisseurs statiques à plusieurs cellules de commutation. Cette méthode permet de faciliter la prise en compte des contraintes de Compatibilité Electromagnétique le plus tôt possible lors de la conception. La méthode proposée consiste en une étude conjointe des perturbations conduites en mode commun et en mode différentiel, en décomposant les circuits en blocs élémentaires, puis en super...

  20. Cellulitis-like symptoms manifested by bone metastasis of lung cancer in a patient living with human immunodeficiency virus.

    Science.gov (United States)

    Kashima, Jumpei; Okuma, Yusuke; Watanabe, Kageaki; Ajisawa, Atushi; Hishima, Tsunekazu

    2016-09-01

    Human immunodeficiency virus (HIV)-infected patients are at a high risk of cancer compared with the general population. As the use of antiretroviral therapy (ART) has increased, non-AIDS-defining cancers have also increased in the past decade. A 61-year-old man with HIV infection on ART developed a painful, erythematous and oedematous lower left leg and an associated fever. He was initially treated with antibiotics for cellulitis but there was no improvement, which warranted further investigation. A translucent lesion was found by X-ray imaging and bone scintigraphy showed bone metastasis from a primary adenocarcinoma of the lung, documented by chest computed tomography and an axillary lymph node biopsy. The patient died three months after the diagnosis despite undergoing chemotherapy. This case demonstrates that physicians should consider metastatic malignancies as a differential diagnoses for diverse skin changes in HIV-infected patients. PMID:26404113

  1. Cellular therapy by mesenchymal stem cells in the gamma radiation-induced multi organ dysfunction syndrome; Therapie cellulaire par cellules souches mesenchymateuses d'une atteinte multi-organes induite par une irradiation gamma: un modele experimental

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Semont, A.; Frick, J.; Sache, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [Institut de Radioprotection et de Surete Nucleaire (IRSN), Direction de la Radioprotection de l' Homme, 92 6 Fontenay-aux-Roses (France); Gorin, N.C. [Universite Paris -6 Pierre et Marie Curie, Faculte de Medecine Saint-Antoine, Lab. de Therapie Cellulaire et Radioprotection Accidentelle, EA 1638, 75 - Paris (France); Hopital Saint-Antoine, Service d' Hematologie et de Therapie Cellulaire, 75 - Paris (France)

    2007-07-15

    Mesenchymal stem cells (M.S.C.) have been shown to migrate to various tissues. There is little information on the fate and potential therapeutic efficacy of the re infusion of M.S.C. following total body irradiation (T.B.I.). We addressed this question using human M.S.C. (h.M.S.C.) infused to non obese diabetic/severe combined immuno-deficient (N.O.D./S.C.I.D.) mice submitted to T.B.I.. Further, we tested the impact of additional local irradiation (A.L.I.) superimposed to T.B.I., as a model of accidental irradiation. N.O.D./S.C.I.D. mice were transplanted with h.M.S.C.. Group 1 was not irradiated before receiving h.M.S.C. infusion. Group 2 received only T.B.I. at a dose of 3.5 Gy, group 3 received local irradiation to the abdomen at a dose of 4.5 Gy in addition to T.B.I., and group 4 received local irradiation to the leg at 26.5 Gy in addition to T.B.I.. Fifteen days after gamma irradiation, quantitative and spatial distribution of the h.M.S.C. were studied. Histological analysis of mouse tissues confirmed the presence of radio-induced lesions in the irradiated fields. Following their infusion into nonirradiated animals, h.M.S.C. homed at a very low level to various tissues (lung, bone marrow, and muscles) and no significant engraftment was found in other organs. T.B.I. induced an increase of engraftment levels of h.M.S.C. in the brain, heart, bone marrow, and muscles. Abdominal irradiation (A.I.) as compared with leg irradiation (L.I.) increased h.M.S.C. engraftment in the exposed area (the gut, liver, and spleen). Comparison of two local irradiations has shown that (L.I.) as compared with (A.I.) increased h.M.S.C. engraftment in the exposed area. An increase of h.M.S.C. engraftment in organs outside the fields of the A.L.I. was also observed. Conversely, following L.I., h.M.S.C. engraftment was increased in the brain as compared with A.I.. This study shows that engraftment of h.M.S.C. in N.O.D./ S.C.I.D. mice with significantly increased in response to tissue injuries following T.B.I. with or without A.L.I.. A.L.I. induced an increase of the level of engraftment at sites outside the local irradiation field, thus suggesting a distant (abscopal) effect of radiation damage. This work supports the use of M.S.C. to repair damaged normal tissues following accidental irradiation and possibly in patients submitted to radiotherapy. (authors)

  2. ETUDE ET SIMULATION DE CELLULES PHOTOVOLTAIQUES A CONTACTS ARRIERES INTERDIGITÉS SOUS ENVIRONNEMENT SILVACO

    OpenAIRE

    MOHAMMEDI, Mohammed

    2012-01-01

    Ces dernières années un engouement particulier a été donné au remplacement des énergies fossiles et fissiles, épuisables, dangereuses et polluantes, par les énergies renouvelables et en particulier le solaire, propres et inépuisables. Grace à l’effet photovoltaïque la conversion de l’énergie solaire en électricité est possible. Depuis les années cinquante plusieurs travaux et élaborations des dispositifs photovoltaïques ont été élaborés. Les premiers travaux étaient destinés su...

  3. Optimisation du rendement des cellules photovoltaiques à heterojonctions GaInP/GaAs

    OpenAIRE

    DJERIOUAT, Khadidja

    2011-01-01

    La consommation d’énergie est nécessaire au développement social et économique. Ces médiocrités rappellent l’extrême importance de la maîtrise énergétique : savoir créer de l’énergie, savoir l’économiser aussi, il y a un compromis entre la production et la consommation et par suite il faut entrer dans une logique forte d’économies d’énergie et augmenter nettement la part des énergies renouvelables. La conversion photovoltaïque est la transformation directe d’une énergie électro...

  4. Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

    OpenAIRE

    Thomas, K.S.; Cox, N H; Savelyich, B S P; Shipley, D.; Meredith, S; A. Nunn; Reynolds, N.; Williams, H.C.; Angus, J; Bell, H.; Bourke, J.; Burge, S.; Ferguson, A.; Finlay, A.; Fulton, R

    2007-01-01

    Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study. Of these, 17 obtained full ethics and Research & Development (R&D) approval, and 15 successfully recruited patients into the study. A total of 70 participants with a diagnosis of cellulitis of the leg were enrolled over a 5-month period. These partici...

  5. Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

    OpenAIRE

    Thomas, Kim S.; Cox, Neil H; Savelyich, Boki SP; Shipley, Debbie; Meredith, Sarah; Nunn, Andrew; Williams, Hywel C.; Reynolds, Nick

    2007-01-01

    Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study. Of these, 17 obtained full ethics and Research & Development (R&D) approval, and 15 successfully recruited patients into the study. A total of 70 participants with a diagnosis of cellulitis of the leg were enrolled over a 5-month period. T...

  6. Endotheliale Dysfunktion der Koronargefäße

    Directory of Open Access Journals (Sweden)

    Britten MB

    2003-01-01

    Full Text Available Die Integrität des Endothels ist essentiell für den Erhalt seiner antiatherosklerotischen Eigenschaften. Hierbei spielt die Balance zwischen dem vaskuloprotektiven NO und den ihm entgegenwirkenden Sauerstoffradikalen, wie Sauerstoffsuperoxid, eine zentrale Rolle (Redoxgleichgewicht. Ist diese Balance gestört, kommt es zur endothelialen Aktivierung mit weitreichender Beeinflussung des lokalen vaskulären Milieus. Proliferationsprozesse, Apoptose und die Aktivierung von Makrophagen und Metalloproteinasen führen zur Plaqueentstehung und schließlich zur Destabilisierung. Instabile Plaques erhöhen die Gefahr eines akuten Koronarsyndroms mit Ausbildung eines Myokardinfarkts und in der Folge dem Auftreten des plötzlichen Herztodes oder myokardialen Pumpversagens. Klinische Untersuchungen bestätigen die prognostische Tragweite der endothelialen Funktionsstörung. Dies wird auch durch die Tatsache unterstrichen, daß potente atheroprotektive Medikamente, wie ACE-Hemmer oder Statine, welche die Prognose von Patienten verbessern, auch mit einer Verbesserung der endothelialen Funktion assoziiert sind.

  7. In situ Identifizierung und Charakterisierung endothelialer Progenitorzellen im bovinen Ovar

    OpenAIRE

    Schoen, Kornelia

    2016-01-01

    In the course of the reproductive cycle, ovaries are subject to considerable changes, which result in an abundant growth of blood vessels during the formation of the corpus luteum and the regression of blood vessels during luteolysis. The process of neovascularization comprises one third of the total length of the ovarian cycle and is more vigorous than in malignant tumors. The origin of these proliferating endothelial cells has not been completely clarified yet. The enclosed doctoral thesis ...

  8. Protection des ions organiques contre les dommages induits a l'ADN par les electrons de basse energie

    Science.gov (United States)

    Dumont, Ariane

    Il a ete demontre que les electrons de basse energie (EBE) peuvent induire des cassures simple brin (CSB) a l'ADN, via la formation d'anions transitoires qui decroissent par attachement dissociatif, ou dans d'autres etats electroniques dissociatifs menant a la fragmentation. Afin d'effectuer une etude complete des effets des electrons de basse energie sur la matiere biologique, il est necessaire de comprendre leur mecanismes d'interaction non seulement avec l'ADN, mais avec les constituants de son environnement. Les histones sont une composante importante de l'environnement moleculaire de l'ADN. Leur charge positive leur permet de s'associer aux groupements phosphate anionique de l'ADN. Le role principal de ces proteines basiques consiste a organiser l'ADN et l'empaqueter afin de former la chromatine. Les cations sont une autre composante importante de la cellule; ils jouent un role dans la stabilisation de la conformation B de l'ADN in vitro par leurs interactions avec les petits et grands sillons de l'ADN, ainsi qu'avec le groupement phosphate charge negativement. Avec les histones, ils participent egalement a la compaction de l'ADN pour former la chromatine. Cette etude a pour but de comprendre comment la presence d'ions organiques (sous forme de Tris et d'EDTA) a proximite de l'ADN modifie le rendement de cassures simple brin induit par les electrons de basse energie. Le Tris et l'EDTA ont-ete choisis comme objet d'etude, puisqu'en solution, ils forment le tampon standard pour solubiliser l'ADN dans les experiences in vitro (10mM Tris, 1mM EDTA). De plus, la molecule Tris possede un groupement amine alors que l'EDTA possede 4 groupements carboxyliques. Ensembles, ils peuvent se comporter comme un modele simple pour les acides amines. Le ratio molaire de 10 :1 de Tris par rapport a l'EDTA a pour but d'imiter le comportement des histones qui sont riches en arginine et lysine, acides amines possedant un groupement amine charge positivement additionnel. Des films d

  9. Performance testing of passive autocatalytic recombiners (PARs)

    International Nuclear Information System (INIS)

    Passive autocatalytic recombiners (PARs) have been under consideration in the U.S. as a combustible gas control system in advanced light water reactor (ALWR) containments for design basis and severe accidents. PARs do not require a source of power. Instead they use palladium or platinum as a catalyst to recombine hydrogen and oxygen gases into water vapor upon contact with the catalyst. Energy from the recombination of hydrogen with oxygen is released at a relatively slow but continuous rate into the containment which prevents the pressure from becoming too high. The heat produced creates strong buoyancy effects which increases the influx of the surrounding gases to the recombiner. These natural convective flow currents promote mixing of combustible gases in the containment. PARs are self-starting and self-feeding under a very wide range of conditions. The recombination rate of the PAR system needs to be great enough to keep the concentration of hydrogen (or oxygen) below acceptable limits. There are several catalytic recombiner concepts under development worldwide. The USNRC is evaluating a specific design of a PAR which is in an advanced stage of engineering development and has been proposed for ALWR designs. Sandia National laboratories (SNL), under the sponsorship and the direction of the USNRC, is conducting an experimental program to evaluate the performance of PARs. The PAR will be tested at the SURTSEY facility at SNL. The test plan currently includes the following experiments: experiments will be conducted to define the startup characteristics of PARs (i.e., to define what is the lowest hydrogen concentration that the PAR starts recombining the hydrogen with oxygen); experiments will be used to define the hydrogen depletion rate of PARs as a function of hydrogen concentration; and experiments will be used to define the PAR performance in the presence of high concentrations of steam. (author)

  10. Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

    Directory of Open Access Journals (Sweden)

    Meredith Sarah

    2007-01-01

    Full Text Available Abstract Background This paper describes the results of a feasibility study for a randomised controlled trial (RCT. Methods Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN expressed an interest in recruiting for this study. Of these, 17 obtained full ethics and Research & Development (R&D approval, and 15 successfully recruited patients into the study. A total of 70 participants with a diagnosis of cellulitis of the leg were enrolled over a 5-month period. These participants were largely recruited from medical admissions wards, although some were identified from dermatology, orthopaedic, geriatric and general surgery wards. Data were collected on patient demographics, clinical features and willingness to take part in a future RCT. Results Despite being a relatively common condition, cellulitis patients were difficult to locate through our network of UK DCTN clinicians. This was largely because patients were rarely seen by dermatologists, and admissions were not co-ordinated centrally. In addition, the impact of the proposed exclusion criteria was high; only 26 (37% of those enrolled in the study fulfilled all of the inclusion criteria for the subsequent RCT, and were willing to be randomised to treatment. Of the 70 participants identified during the study as having cellulitis of the leg (as confirmed by a dermatologist, only 59 (84% had all 3 of the defining features of: i erythema, ii oedema, and iii warmth with acute pain/tenderness upon examination. Twenty-two (32% patients experienced a previous episode of cellulitis within the last 3 years. The median time to recurrence (estimated as the time since the most recent previous attack was 205 days (95% CI 102 to 308. Service users were generally supportive of the trial, although several expressed concerns about taking antibiotics for lengthy periods, and felt that multiple morbidity/old age would limit entry into a 3-year study. Conclusion This pilot study has been

  11. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  12. Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1

    OpenAIRE

    Grishina, Zoryana; Ostrowska, Ewa; Halangk, Walter; Sahin-Tóth, Miklós; Reiser, Georg

    2005-01-01

    Trypsin-like serine proteinases trigger signal transduction pathways through proteolytic cleavage of proteinase-activated receptors (PARs) in many tissues. Three members, PAR-1, PAR-2 and PAR-4, are trypsin substrates, as trypsinolytic cleavage of the extracellular N terminus produces receptor activation. Here, the ability of the three human pancreatic trypsin isoforms (cationic trypsin, anionic trypsin and mesotrypsin (trypsin IV)) as recombinant proteins was tested on PARs.Using fura 2 [Ca2...

  13. Computed tomographic patterns of orbital cellulitis due to sinusitis Padrões tomográficos de celulite orbitária secundária à sinusite

    Directory of Open Access Journals (Sweden)

    Filipe José Pereira

    2006-08-01

    Full Text Available PURPOSE: To describe the CT findings of orbital cellulitis due to sinusitis. METHODS: The records and CT scans of 45 consecutive patients with orbital cellulitis due to sinusitis treated at the Hospital of the Medical School of Ribeirão Preto were analyzed by a radiologist and two orbital surgeons. RESULTS: Three major types of CT changes were observed: diffuse fat infiltration, subperiosteal abscess and orbital abscess. Diffuse fat infiltration (characterized by an increased density of the extra- or intraconal fat was seen in 11 patients (24.44%. A subperiosteal abscess was diagnosed in 28 patients (62.23%. A surgically proved orbital abscess was detected in 6 patients (13.33%. CONCLUSIONS: In all cases of orbital cellulitis due to sinusitis intraorbital changes can be detected by CT scans either as a diffuse infiltration of the orbital fat or as a detachment of the periorbita (subperiosteal abscess or a true orbital abscess. Category I of Chandler orbital cellulitis classification (inflammatory edema must be understood as a stage of a process that is already happening within the orbit and, as the term "preseptal cellulitis" means a palpebral infection, this designation should not be used to stage orbital cellulitis.OBJETIVO: Descrever os achados tomográficos em celulites orbitárias secundárias à sinusite. MÉTODOS: Os prontuários e filmes tomográficos de 45 pacientes consecutivos com celulite orbitária secundária à sinusite tratados no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto foram analisados por um radiologista e dois cirurgiões de órbita. RESULTADOS: Três principais tipos de alterações tomográficas foram observadas: infiltração difusa da gordura, abscesso subperiósteo e abscesso orbitário. Infiltração difusa da gordura (caracterizada por aumento da densidade da gordura extra ou intraconal foi vista em 11 pacientes (24,44%. Abscesso subperiósteo foi diagnosticado em 28 pacientes (62

  14. Radioecological implications of the Par Pond drawdown

    International Nuclear Information System (INIS)

    The drawdown of the Par Pond reservoir created dramatic alterations in this formerly stable lentic ecosystem. In addition, the radiation environment at Par Pond has changed significantly because of the exposure of Cesium 137-contaminated sediments and the appearance of new transport pathways to the terrestrial environment. In response to this situation, SREL was asked to study the radioecological implications of the reservoir drawdown. This report contains the objectives, methods, and results of the SREL study

  15. Étude de transfert des films minces de silicium monocristallin dans la réalisation de cellule solaire à faible budget thermique

    OpenAIRE

    BENCHERRAT, Abdennebi

    2012-01-01

    La production de l‟électricité à partir de l‟énergie solaire est devenue très importante ce qui conduit à développer les cellules photovoltaïques et améliorer leurs rendements. Le silicium est le matériau le plus largement utilisé pour la conversion photovoltaïque. Cependant, le coût du silicium constitue près de 50 % du prix de revient d'un module photovoltaïque. La réduction de consommation de matériau silicium est une solution très importante.

  16. Studio dei polimorfismi genici degli antigeni minori di istocompatibilità e GvHD/GvL nel trapianto allogenico di cellule staminali emopoietiche

    OpenAIRE

    Cattina, Federica

    2013-01-01

    L'outcome dei pazienti sottoposti a trapianto allogenico di cellule staminali emopoietiche è fortemente influenzato da graft versus leukemia (GvL) e graft versus host disease (GvHD) che sono mediate, almeno in parte, dagli antigeni minori di istocompatibilità (mHAgs). In letteratura sono stati identificati 26 mHAgs che sono stati correlati a GvHD/GvL con risultati incompleti e in alcuni casi contrastanti; inoltre manca una metodica che sia in grado di genotipizzare contemporaneamente un p...

  17. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  18. Films minces à base de Si nanostructuré pour des cellules photovoltaïques de 3ème génération.

    OpenAIRE

    Nalini, R.P.

    2012-01-01

    L'association du concept de troisième génération de cellules solaires et de la technologie de fabrication des films minces ouvre la voie à l'élaboration de matériaux entrant dans le cadre des énergies renouvelables. Les effets de confinement quantiques observés dans les nanostructures de silicium sont exploités pour une intégration dans des dispositifs du type cellule tandem tout-silicium. Cette thèse vise à comprendre la formation de nanoparticules de silicium dans deux types de ...

  19. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis...... partition and promoter repression complexes. Surprisingly, ParB repressed transcription of the noncognate par operon, indicating cross-talk and possibly epistasis between the two systems. The par promoters, P1 and P2, affected each other negatively. The DNA binding activities of ParR and ParB correlated...

  20. The role of 99mTc-labelled stannous colloid white blood cells scanning in the evaluation of and differentiation between cellulitis and osteomyelitis

    International Nuclear Information System (INIS)

    Full text: Sequential 99mTc-MDP and 67Ga-citrate scanning have been extensively used in the evaluation of infection. 99mTc-labelled stannous colloid white blood cell (Tc-WBC) is not widely reported. A prospective study was undertaken in 92 patients to assess Tc-WBC and Tc-MDP scanning in this clinical application. Labelling efficiency (LE) was calculated with a mean ± SD of 94 ± 4.8 %. Patients (6) who were treated with gentamycin had an LE ± SD of 70 ± 9%. Twenty six patients treated as osteomyelitis had congruent abnormalities on Tc-WBC and Tc-MDP scans. Twenty one patients treated as cellulitis had abnormalities demonstrated on Tc-WBC but not on Tc-MDP scans. Tc-WBC appeared to define areas of inflammation of bone and soft-tissue in the hands or feet more distinctly than Tc-MDP. Fourteen patients had progress Tc-WBC scans 4-6 weeks following antibiotic treatment. Changes in scan appearances seemed to mirror the clinical course of the patients. Tc-WBC and Tc-MDP scans were useful complementary studies in the diagnosis, evaluation and assessment of treatment in patients with cellulitis and osteomyelitis

  1. Structural analysis of the ParR/parC plasmid partition complex

    DEFF Research Database (Denmark)

    Møller-Jensen, Jakob; Ringgaard, Simon; Mercogliano, Christopher P;

    2007-01-01

    Accurate DNA partition at cell division is vital to all living organisms. In bacteria, this process can involve partition loci, which are found on both chromosomes and plasmids. The initial step in Escherichia coli plasmid R1 partition involves the formation of a partition complex between the DNA....... coli plasmid pB171. ParR forms a tight dimer resembling a large family of dimeric ribbon-helix-helix (RHH)2 site-specific DNA-binding proteins. Crystallographic and electron microscopic data further indicate that ParR dimers assemble into a helix structure with DNA-binding sites facing outward. Genetic...... and biochemical experiments support a structural arrangement in which the centromere-like parC DNA is wrapped around a ParR protein scaffold. This structure holds implications for how ParM polymerization drives active DNA transport during plasmid partition....

  2. The Expression of the Thrombin Receptors PAR-3 and PAR-4 is Downregulated in Pancreatic Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Claudia Rudroff

    2015-05-01

    Full Text Available Background: Patients with pancreatic cancer frequently suffer from thrombosis as a consequence of excess thrombin generation. In addition to its role in the plasmatic coagulation cascade, thrombin induces numerous cellular effects by activating a unique group of G-protein-coupled receptors on the cell membrane, the proteinase-activated receptors (PARs. At present, PAR-1, PAR-3 and PAR-4 are known to be activated by thrombin. We previously demonstrated a putative role for PAR-1 in pancreatic cancer progression, but little is known about the physiological and pathophysiological roles of PAR-3 and PAR-4. In the present study, we examined the expression patterns of PAR-3 and PAR-4 in pancreatic tissue and pancreatic cancer cells. Methods: Tissue samples from three patients with pancreatic adenocarcinoma and six human pancreatic carcinoma cell lines were examined. Gene expression was analysed by RT-PCR and quantified by HPLC. Protein expression was determined by Western blot analysis. Data analysis was performed using ANOVA in SPSS. Results and Conclusion: In contrast to PAR-1, both PAR-3 and PAR-4 were expressed in healthy pancreases but downregulated in pancreatic cancer. The contrasting expression patterns of PAR-3 and PAR-4 compared with PAR-1 indicate that the mechanism that regulates the cellular effects of thrombin on tumor progression remains to be fully elucidated.

  3. Traitement des eaux par électrofloculation

    OpenAIRE

    Cansado, Isabel

    1997-01-01

    Traitement des eaux par electrofloculation Les écosystèmes aquatiques sont très affectés par les eaux de rejet qui sont déversées dans les cours d’eau. La charge de ces eaux existe sous diverses formes: solutés, colloïdes ou particules. Il est important de traiter l’eau usée à de faibles coûts au lieu de la rejeter directement dans le milieu récepeteur. Dans le but d’améliorer les procédés physico-chimiques de déstabilisation des émulsions, nous étudions les traitements par électrocoagulat...

  4. Programmation par contraintes avec des fourmis

    OpenAIRE

    Khichane, Madjid; Albert, Patrick; Solnon, Christine

    2008-01-01

    National audience On explore dans cet article les possibilités d'intégration de la métaheuristique d'optimisation par colonies de fourmis (ACO) dans un langage de programmation par contraintes (PPC). L'idée est d'utiliser un langage de PPC pour décrire le problème à résoudre, ainsi que pour propager et vérifier les contraintes, et d'utiliser ACO pour guider la recherche de solutions. On illustre notre approche sur le problème d'ordonnancement de voitures.

  5. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation.

    Science.gov (United States)

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara

    2016-04-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  6. SWANN ORGANIQUE (EN PASSANT PAR BECKETT PANOPTIQUE

    Directory of Open Access Journals (Sweden)

    Sjef Houppermans

    2013-12-01

    Full Text Available Comme quoi Swann a bel et bien un corps souffrant et jouissant. Comme quoi Swann absorbe le monde surtout par ses six sens. Comme quoi l´univers de Swann est une aire de dissémination que Samuel Beckett sonde exemplairement dans son étude de 1930.

  7. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    International Nuclear Information System (INIS)

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  8. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition Assembly

    Energy Technology Data Exchange (ETDEWEB)

    B Chaudhuri; S Gupta; V Urban; M Chance; R DMello; L Smith; K Lyons; J Gee

    2011-12-31

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  9. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhuri, Barnali [University of Buffalo, The State University of New York; Gupta, Sayan [Case Western Reserve University; Urban, Volker S [ORNL; Chance, Mark [Case Western Reserve University; D' Mello, Rhijuta [Case Western Reserve University; Smith, Lauren [University of Buffalo, The State University of New York; Lyons, Kelly [University of Buffalo, The State University of New York; Gee, Jessica [University of Buffalo, The State University of New York

    2010-01-01

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  10. What Is Cellulitis?

    Science.gov (United States)

    ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ...

  11. Cellulitis and Erysipelas

    Science.gov (United States)

    ... long-term) swelling of your arms or legs (lymphedema). Diagnosis Your healthcare provider may take a sample or culture from your skin lesions to identify the bacteria causing infection. He or she may also recover the bacteria from your blood. Treatment Depending on how severe the infection is, your ...

  12. Etude de la réponse immunitaire T au cours de l'artérite à cellules géantes (Maladie de Horton)

    OpenAIRE

    Samson, Maxime

    2014-01-01

    Ce travail de thèse a été axé sur l’étude de la réponse immunitaire T chez des patients atteints d’artérite à cellules géantes (ACG) et de pseudo-polyarthrite rhizomélique (PPR). Plusieurs études cliniques successives interrégionales ont permis d’inclure de nombreux patients (57 ACG et 27 PPR) des Centres Hospitaliers (CH) Universitaires et des CH de l’interrégion Est. Les échantillons sanguins ont été étudiés dans le laboratoire de l’unité INSERM U1098. Tout d’abord, nous avons confirmé l’im...

  13. Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

    Directory of Open Access Journals (Sweden)

    Ledina Dragan

    2012-11-01

    Full Text Available Abstract Introduction Campylobacter is an important causative agent of intestinal infections in humans. Bacteremia is detected in less than 1% of patients, mainly in immunocompromised patients and in extreme age groups. Cellulitis is a relatively common manifestation of Campylobacter infection, but concomitant bacteremia is a rare event. Infections of the pacemaker area are caused primarily by staphylococci, followed by fungi, streptococci and Gram-negative rods. To the best of our knowledge, this is the first case report of pacemaker pocket infection and bacteremia caused by Campylobacter fetus. Case presentation A 72-year-old Croatian Caucasian man with myelodysplasia, impaired fasting glucose levels and a recently implanted permanent pacemaker was admitted to hospital after six days of fever, development of red swelling of the pacemaker pocket area and worsening of his general condition. No antibiotic therapy was introduced in the outpatient setting. He denied any recent gastrointestinal disturbances. With the exception of an elevated leukocyte count, erythrocyte sedimentation rate, and C-reactive protein and blood glucose levels, other laboratory findings were normal. Treatment with vancomycin plus netilmicin was introduced, and a surgical incision with drainage of the pacemaker pocket was performed. The entire pacemaker system was removed and a new one re-implanted after 14 days of antibiotic therapy. Transesophageal echocardiography showed no pathological findings. Three subsequent blood cultures obtained on admission as well as swab culture of the incised pacemaker area revealed Campylobacter fetus; stool and pacemaker lead cultures were negative. According to the microbiological results, antibiotic therapy was changed to ciprofloxacin plus netilmicin. A clinical examination and the results of a laboratory analysis performed after two weeks of therapy were within normal limits. Conclusion Myelodysplasia, impaired fasting glucose levels

  14. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  15. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas;

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  16. Les Brulures Chimiques Par Le Laurier Rose

    OpenAIRE

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose ...

  17. Annotation sémantique par classification

    OpenAIRE

    Toussaint, Yannick; Tenier, Sylvain

    2007-01-01

    Les systèmes actuels d'annotation sémantique exploitent peu les connaissances du domaine et fonctionnent essentiellement du texte vers l'ontologie. Pourtant, il est fréquent qu'un élément dans une page doive être annoté par un concept parce que certains autres éléments de cette même page sont annotés par d'autres concepts. Cet article propose une méthode d'annotation prenant en compte cette dépendance entre concepts, exprimée dans une ontologie sous forme de concepts définis. L'utilisation de...

  18. Recombination in the Human Pseudoautosomal Region PAR1

    OpenAIRE

    Anjali G Hinch; Nicolas Altemose; Nudrat Noor; Peter Donnelly; Simon R Myers

    2014-01-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this o...

  19. Par Pond refill water quality sampling

    International Nuclear Information System (INIS)

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  20. Combined DSEK and Transconjunctival Pars Plana Vitrectomy

    Directory of Open Access Journals (Sweden)

    Mona Sane

    2016-01-01

    Full Text Available We report here three patients who underwent combined Descemet’s stripping with endothelial keratoplasty and transconjunctival pars plana vitrectomy for bullous keratopathy and posterior segment pathology. A surgical technique and case histories are described. Anatomic and visual outcomes of combined Descemet’s stripping with endothelial keratoplasty and vitrectomy were excellent. Our experience provides technical guidelines and limitations. The combined minimally invasive techniques allow for rapid anatomical recovery and return of function and visual acuity in a single sitting.

  1. Taare Zameen Par and dyslexic savants

    OpenAIRE

    Chakravarty, Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were pr...

  2. Origine et développement des cellules germinales chez l'huître Crassostrea gigas : intérêt pour le contrôle de la reproduction en écloserie

    OpenAIRE

    Fabioux, Caroline

    2004-01-01

    Le renouvellement annuel de la population de cellules germinales chez l'huître creuse Crassostrea gigas est une étape clé de son cycle de reproduction. La compréhension de ces mécanismes est essentielle à la maîtrise de la reproduction contrôlée de C. gigas, indispensable pour répondre à une demande croissante des ostréiculteurs, de naissain produit en écloserie. Les objectifs de cette étude étaient de déterminer l'origine et les mécanismes de renouvellement annuel des cellules germinales de ...

  3. Characterisation in vivo of ways of induced deaths by p53, in the male germinal cells; Caracterisation in vivo des voies de mort induites par la p53, dans les cellules germinales males

    Energy Technology Data Exchange (ETDEWEB)

    Coureuil, M

    2006-10-15

    The male germinal cells constitute a heterogeneous cell population including pre-meiotic proliferating cells (spermatogonia) and meiotic cells and post meiotic cells in differentiation (spermatocytes and spermatids). We study the involvement in vivo of the p53 protein in the death of these cells with the help of two models, (1) a transgenic model of infertility, MTp53, in which the p53 is over expressed in the differentiated cells and induced their death, (2) the response of these cells to gamma irradiation, where only the spermatogonia die by apoptosis dependent of p53. We showed that the caspases (cysteine-aspartic proteases) are involved in the terminal differentiation of normal germinal cells. But in the MTp53 model, the p53 induces the death of differentiated cells via the activation of calpains and not of caspases. We studied the response of spermatogonia, to gamma irradiation by a transcriptomic approach, by DNA chips and semi-quantitative RT-PCR. we showed that the puma and dr5 genes are induced by the p53 after irradiation. more, the study of mice invalidated for trail ( the dr5 ligand) or for puma, allowed to demonstrate that the two effectors are essential to the activation of intrinsic and extrinsic ways of apoptosis. (N.C.)

  4. L'oxyde de zinc par dépôt chimique en phase vapeur comme contact électrique transparent et diffuseur de lumière pour les cellules solaires

    OpenAIRE

    Faÿ, Sylvie

    2003-01-01

    Zinc oxide (ZnO) is a material that belongs to the family of Transparent Conductives Oxides (TCO). Its non-toxicity and the abundant availability in the Earth's crust of its components make it an ideal candidate as electrical transparent contact for thin-film amorphous and/or microcrystalline silicon solar cells. The Low-Pressure Chemical Vapour Deposition (LP-CVD) method allows one to obtain rough ZnO layers, which can effectively scatter the light that passes through them. This high scatter...

  5. L'oxyde de zinc par dépôt chimique en phase vapeur comme contact électrique transparent et diffuseur de lumière pour les cellules solaires

    OpenAIRE

    Faÿ, Sylvie; Shah, Arvind V.

    2005-01-01

    Zinc oxide (ZnO) is a material that belongs to the family of Transparent Conductives Oxides (TCO). Its non-toxicity and the abundant availability in the Earth’s crust of its components make it an ideal candidate as electrical transparent contact for thin-film amorphous and/or microcrystalline silicon solar cells. The Low-Pressure Chemical Vapour Deposition (LP-CVD) method allows one to obtain rough ZnO layers, which can effectively scatter the light that passes through them. This high scatter...

  6. Aggressive large cell lymphoma: early assessment of therapeutic efficacy by positron emission tomography; Lymphome agressif a grandes cellules: appreciation precoce de l'efficacite therapeutique par la TEP au [{sup 18}F]-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Itti, E.; Maignan, M. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Medecine Nucleaire, 94 - Creteil (France); Haioun, C.; Reyes, F. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service d' Hematologie Clinique, 94 - Creteil (France); Rahmouni, A. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Radiologie, 94 - Creteil (France)

    2004-07-01

    The international prognostic index is a well-established tool for stratifying patients with aggressive non-Hodgkin's lymphoma scheduled for tailored therapy. Early FDG-PET imaging could play a major predictive role for patient survival by providing functional information about lymphoma chemo-sensitivity. We present here the results of the interim analysis (about SD patients) of a prospective multi-centre study (national PHRC), the goals of which were to correlate PET response after 2 induction cycles 1) to the therapeutic response assessed by conventional diagnostic methods and 2) to event free survival and global survival. (author)

  7. Study and fabrication of solid oxide fuel cells through tape casting and co-sintering; Etude et realisation par coulage en bande et co-frittage de cellules de pile a combustible a oxydes solides

    Energy Technology Data Exchange (ETDEWEB)

    Grosjean, A

    2004-11-15

    This work is dedicated to the devising of a low-cost fabrication process of solid oxide fuel cells (SOFC). Technical requirements impose the shaping method: stripe casting as well as the materials used: Yttria-stabilized zirconia (YSZ), nickel and lanthanum manganite doped with strontium (LSM). In order to comply with environmental requirements the developed process uses an aqueous barbotine solvent. We get electrodes and the electrolyte separately, the use of an absorbent drying process has enabled us to join 3 layers to form an elementary cell with great interfacial homogeneity. The resistance of the cell to sintering has been improved through the symmetrization of the deformations of the cell. In order to interpret the low electrical properties of the cell and its quick damaging, transmission microscopy studies have been performed. These studies have shown 2 facts. First, 2 isolating phases appear at the cathode (at the LSM/YSZ interface) because of a too high sintering temperature and secondly, a quick clustering of nickel grains appears during cell operation that leads to a local loss of the nickel grid percolation. This problem has been solved by increasing the size of nickel oxide grains from 0.5 {mu}m to 3 {mu}m) to stabilize the microstructure. The issue of the reactivity at the LSM/YSZ interfaces was tackled in 2 different ways, we have tried to lower the sintering temperature by using a zirconia nano-powder first and then by replacing zirconia in the electrolyte by gadolinium-doped ceria. The use of zirconia nano-powder has failed to decrease sintering temperature while preserving the electrolyte density and the use of ceria has triggered instabilities that have not yet been solved. Despite all these drawbacks, this process allows the fabrication of an excellent anode/electrolyte interface. (A.C.)

  8. Cellules électrochimiques produisant du gaz : suivi de l'électrolyse par émission acoustique et effets de la mouillabilité des électrodes sur le flux des charges électriques

    OpenAIRE

    Brussieux, Charles

    2011-01-01

    Molten salts electrochemical processes, like fluorine and aluminium production processes produce bubbles on electrodes slightly wetted by an electrolyte. In those cells, the electrolyte convection is mainly induced by the motion of bubbles. Then, the residence time of gas is not under control and the modelling of such electrolysis still faces many challenges. This work begins with a collection of the information required to model gas-producing cells. We developed an electrochemical composite ...

  9. NANOMEDECINE EN ONCOLOGIE : Etude des Interactions Entre les Nanoparticules Activables par des Sources d'Energie Electromagnétique Externes et les Cellules Cancéreuses pour Elargir la Fenêtre Thérapeutique

    OpenAIRE

    Virginie, Simon,

    2009-01-01

    La compréhension des interactions entre les nanomatériaux et les entités biologiques est fondamentale pour développer des nanoproduits en oncologie. NBTXR3 (nanoparticule inerte d'oxyde d'hafnium) et protoporphyrine IX (Pp IX) nanotransporteur (nanoparticule de silice encapsulant le Pp IX, le monomère du Photofrin®) sont des nanoproduits, issus des plateformes Nanobiotix, développés pour élargir la fenêtre thérapeutique des traitements du cancer en utilisant des sources d'activation externe d...

  10. Evaluation of the PAR corneal topography system

    Science.gov (United States)

    Jindal, Prateek; Cheung, Susan; Pirouzian, Amir; Keates, Richard H.; Ren, Qiushi

    1995-05-01

    The purpose of this study was to evaluate the raster photogrammetry based Corneal Topography System by determining: inter-operator variability, reproducibility of images, effects of defocused and decentered images, and the precision of data at different optical zones. 4 human cadaver eyes were used to study the inter-operator variability. To study the reproducibility of images, 3 human cadaver eyes and a test surface doped with flourescine (provided by PAR Vision Systems Corporation) were focused and their images taken four successive times. Defocused and decentered images were taken of 4 human cadaver eyes and four times of the test surface mentioned above. The precision of defocused/decentered cadaver eyes was evaluated at the following optical zones: 3 mm, 4 mm, 5 mm, and 6 mm. All human cadaver eyes used in the above experiments had their epithelial layer removed before imaging. Average inter-operator variability was 0.06 D. In reproducibility attempts, there was an average deviation of 0.28 D for the human cadaver eyes and 0.04 D for the test surface. The defocused and decentered test surface gave an average deviation of 0.09 D. Defocused and decentered cadaver eyes resulted in an average deviation of 0.52 D, 0.37 D, 0.24 D, and 0.22 D at optical zones of 3 mm, 4 mm, 5 mm, and 6 mm, respectively. The imaging method employed by PAR Vision Systems Corporation virtually eliminates inter-operator variability. The PAR Corneal Topography System's clinical usefulness, however, could be improved by improving the reproducibility of images, decreasing the sensitivity to spatial alignment, and increasing accuracy over smaller optical zones.

  11. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  12. Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis.

    Science.gov (United States)

    Asdourian, Maria S; Skolny, Melissa N; Brunelle, Cheryl; Seward, Cara E; Salama, Laura; Taghian, Alphonse G

    2016-09-01

    Precautionary recommendations conveyed to survivors of cancer by health-care practitioners to reduce the risk of breast cancer-related lymphoedema are indispensable aspects of clinical care, yet remain unsubstantiated by high-level scientific evidence. By reviewing the literature, we identified 31 original research articles that examined whether lifestyle-associated risk factors (air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and skin infections-eg, cellulitis) increase the risk of breast cancer-related lymphoedema. Among the few studies that lend support to precautionary guidelines, most provide low-level (levels 3-5) or inconclusive evidence of an association between lymphoedema and these risk factors, and only four level 2 studies show a significant association. Skin infections and previous infection or inflammation on the ipsilateral arm were among the most clearly defined and well established risk factors for lymphoedema. The paucity of high-level evidence and the conflicting nature of the existing literature make it difficult to establish definitive predictive factors for breast cancer-related lymphoedema, which could be a considerable source of patient distress and anxiety. Along with further research into these risk factors, continued discussion regarding modification of the guidelines and adoption of a risk-adjusted approach is needed. PMID:27599144

  13. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  14. Identification des gaz combustibles par capteur catalytique

    OpenAIRE

    Rose, Gérard

    1995-01-01

    L'explosimètre est un instrument destiné à prévenir le risque d'inflammation d'un mélange d'air et de gaz en informant de la présence du gaz par une alarme, et en délivrant une mesure qu'il exprime en pourcentage de la limite inférieure d'explosivité du mélange (LIE). Il répond à tous les gaz et vapeurs combustibles, mais il ne donne une mesure juste que pour un seul d'entre-eux : celui pour lequel il a été étalonné. Cet inconvénient est sans conséquence si l'utilisateur identifie le gaz, car...

  15. Parálisis cerebral Cerebral palsy

    OpenAIRE

    Jorge Malagon Valdez

    2007-01-01

    El término parálisis cerebral (PC) engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia me...

  16. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations. PMID:20142854

  17. Taare Zameen Par and dyslexic savants

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar

    2009-01-01

    Full Text Available The film Taare Zameen Par (Stars upon the Ground portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ′disinhibits′ the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  18. Paris vu par Jaime Gil de Biedma

    OpenAIRE

    Massip, Estrella

    2013-01-01

    Le poème París, postal del cielo de l’écrivain barcelonais en langue castillane Jaime Gil de Biedma (1929-1990) laisse entendre une multiplicité de voix dont chacune nous communique une image de Paris. C’est la mémoire du « je » poétique qui filtre cette polyphonie. Le voyage dans le Paris réel qui est à l’origine du poème est aussi le voyage de Gil de Biedma lecteur dans le double littéraire de cette ville. Les rapports intertextuels avec les œuvres de Blas de Otero et de Baudelaire permette...

  19. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  20. Contribution a l'industrialisation du soudage par friction malaxage

    OpenAIRE

    Zimmer, Sandra

    2009-01-01

    Le soudage par friction malaxage, ou FSW, est un procédé de soudage à l'« état solide » permettant d'éviter certains problèmes rencontrés en soudage par fusion comme la fissuration à chaud ou la création de soufflures. La soudure est réalisée par l'action d'un outil à l'interface de deux pièces à souder. Celui-ci a pour rôle de malaxer et d'échauffer par frottement la matière. Le cordon est réalisé de proche en proche. Les efforts générés à l'interface outil/matière doivent être repris par la...

  1. ANISOTROPIE STRUCTURELLE INDUITE PAR L'ETIRAGE A CHAUD D'UNE PREFORME EN SILICE PURE – ETUDE PAR DYNAMIQUE MOLECULAIRE ET PAR SPECTROMETRIE RAMAN

    OpenAIRE

    Bidault, Xavier; Chaussedent, Stéphane; Blanc, Wilfried; R. Neuville, D.

    2014-01-01

    Cette étude révèle un nouvel aspect sur la structure de la silice à l'échelle nanométrique. L'orientation acquise par les petits anneaux (Si-O) n pour n ≤ 5 suite à la déformation à chaud persiste à froid et induit une anisotropie structurale dont la forme « isotropie transverse » est vérifiée par spectrométrie Raman.

  2. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  3. Recombination in the human Pseudoautosomal region PAR1.

    Science.gov (United States)

    Hinch, Anjali G; Altemose, Nicolas; Noor, Nudrat; Donnelly, Peter; Myers, Simon R

    2014-07-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome. PMID:25033397

  4. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  5. Einfluss der Stimulation nikotinerger Rezeptoren auf die endotheliale PTHrP-Expression und die endotheliale Suszeptibilität gegenüber Apoptose

    OpenAIRE

    Röthig, Anja

    2009-01-01

    Diese Studie sollte untersuchen, ob eine nAChR Aktivierung durch Nikotin zu einer gesteigerten PTHrP-Expression führt und dies eine Änderung der Apoptosesuszeptibilität von Endothelzellen zur Folge hat. Die Versuche wurden in vitro an isolierten Endothelzellen der Ratte durchgeführt. Nikotin wird als Therapeutikum bei Demenzerkrankungen, z.B. Alzheimer, diskutiert. Die Stimulation der nAChR soll der bei dieser Erkrankung auftretenden Gefäßrarefizierung im Gehirn entgegenwirken. PTHrP senk...

  6. Cells for the examination of irradiated plutonium fuel elements - two years operation - may 1961/may 1963 (1963); Cellules pour examen d'elements combustibles au plutonium irradies - deux ans d'exploitation - mai 1961/mai 1963 (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Valentin, A. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1963-07-01

    Within the framework of the 'Rapsodie' fast reactor program, prototype plutonium fuel elements are irradiated and then examined in an {alpha} {beta} {gamma} laboratory at Saclay. This laboratory consists of five in line cells and a lead enclosure microscope. Each cell contains an {alpha} sealed removable box 4 ft 3 in. high, 4 ft 11 in. wide and 5 ft 1 in. deep, fitted with one or two magnetic transmission indirect manipulators. The boxes are contained in an {beta} {gamma} shielded enclosure whose front face is constructed of cast iron panels 21-2/3 in. thick. Nitrogen circulating in a closed loop forms the atmosphere of the boxes. This laboratory is essentially intended for metallurgical research. The functions of the various cells are as follows: transferring and packing, cutting, density measurement and cathodic etching, storage and metallography. Work on radioactive materials began in April 1961. Operational incidents have always been of a material nature only. (author) [French] Dans le cadre du projet de reacteur rapide Rapsodie, des elements combustibles prototypes au plutonium sont, apres irradiation, examines a Saclay dans un laboratoire {alpha} {beta} {gamma}. Celui-ci comprend cinq cellules en ligne et une enceinte en plomb contenant un microscope telecommande. Chaque cellule est constituee d'un caisson etanche (1, 3 m x 1, 5 m x 1, 56m) equipee d'un ou deux manipulateurs indirects a transmissions magnetiques. Les caissons sont places, dans une enceinte {beta} {gamma} dont la face avant est formee de blocs en fonte ayant 55 cm d'epaisseur. L'atmosphere des caissons est de l'azote, circulant en circuit ferme. Ce laboratoire est destine essentiellement a des recherches metallurgiques. Les fonctions des differentes cellules sont: conditionnement et transferts, tronconnage, mesure de densite et polissage ionique, stockage, metallographie. Le travail sur materiaux radioactifs a commence en avril 1961. Les incidents d

  7. PARs for combustible gas control in advanced light water reactors

    International Nuclear Information System (INIS)

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  8. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle; Friberg, Hans

    2015-01-01

    pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...... characteristic curve (ROC)-analyses were performed, and area under the curve (AUC) was calculated. Time to return of spontaneous circulation (ROSC) was correlated to suPAR levels. RESULTS: Fifty-five patients (40 male, median 65 years) were included, and 33 (60%) were alive after 6 months. The suPAR levels were...... significantly higher in nonsurviving patients compared with survivors at 6 and 36 hours (p=0.006 and 0.034 respectively), but not at 72 hours. The suPAR levels increased from 6 to 72 hours (p<0.0001). Time to ROSC correlated positively with suPAR levels at 6 hours (p=0.003) but not at 36 and 72 hours. ROC...

  9. Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C

    OpenAIRE

    Blanchard, Géraldine; Siegrist, Claire-Anne

    2007-01-01

    "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugué contre le sérogroupe C fait partie du plan de vaccination de routine. Chez les enfants de moins d'une année, 3 doses de vaccin induisent une montée importante des anticorps bactéricides, mais qui ne persistent pas au-delà d'une année. Les cellules B mémoires, semblent essentielles pour protéger les jeunes enfants primo-immunisés comme nourrissons. Dans...

  10. Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C

    OpenAIRE

    Blanchard Rohner, Géraldine

    2006-01-01

    "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugué contre le sérogroupe C fait partie du plan de vaccination de routine. Chez les enfants de moins d'une année, 3 doses de vaccin induisent une montée importante des anticorps bactéricides, mais qui ne persistent pas au-delà d'une année. Les cellules B mémoires, semblent essentielles pour protéger les jeunes enfants primo-immunisés comme nourrissons. Dans...

  11. Measurement of the radial diffusion constant at AQUILON 2 by means of the study of the distortion of the fine structure; Mesures du coefficient de diffusion radial dans AQUILON 2 par l'etude de la distorsion de la structure fine

    Energy Technology Data Exchange (ETDEWEB)

    Gaunet, Ph.; Mazarakis, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    This report gives several measurements of the radial diffusion constant of thermal neutrons by means of the study of the interaction of macroscopic flux and of fine structure in Aquilon II. The use of two type of clusters allows to compare the effect of the fuel distribution on the radial diffusion constant. Two types of measurement have been used: - macroscopic or 'amont-aval' method in which the perturbation brought by the microscopic flux on the macroscopic flux is measured; - microscopic or 'fine structure' method, which analyses the distortion of the fine structure of a cell under the effect of the macroscopic flux. (authors) [French] Ce rapport presente plusieurs mesures du coefficient de diffusion radial des neutrons thermiques par l'etude de l'interaction du flux macroscopique et de la structure fine dams AQUILON II. L'utilisation de deux sortes de grappes permet une comparaison de l'influence de la repartition du combustible sur le coefficient de diffusion radial. Deux types de mesure ont ete utilises: - mesure 'macroscopique' ou 'amont-aval', dans laquelle on mesure la perturbation apportee par le flux microscopique sur le flux macroscopique; - mesure 'microscopique' ou 'de structure fine', qui analyse la distorsion de la structure fine d'une cellule sous l'influence du flux macroscopique. (auteurs)

  12. PAR elevation influence on hydrogen floor layer depth

    International Nuclear Information System (INIS)

    In order to circumvent problems associated with containment loads resulting from a possible hydrogen combustion, French containments for instance are equipped with passive autocatalytic recombiners (PAR). The aim of this safety device is to recombine hydrogen with oxygen in order to limit hydrogen concentration. Hence, PAR distribution within the containment is a key feature to limit the hydrogen risk. According with the PARIS benchmark scenario and boundary conditions therein (EU-FP6, SARNET project) a floor layer developed with low mass and thermal mixing processes. In this paper we illustrate the link between the PAR elevation and the floor layer depth. (author)

  13. Endophthalmitis following pars plana vitrectomy for vitreous floaters

    Directory of Open Access Journals (Sweden)

    Henry CR

    2014-08-01

    Full Text Available Christopher R Henry, Stephen G Schwartz, Harry W Flynn Jr Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: A case of Staphylococcus caprae endophthalmitis in a young patient following pars plana vitrectomy for symptomatic vitreous floaters is reported here. Recent literature suggests that there is an increasing trend of performing pars plana vitrectomy for symptomatic floaters. Although rare, the potential risk of endophthalmitis should be explicitly discussed with patients considering surgical intervention for vitreous floaters. Keywords: endophthalmitis, pars plana vitrectomy, vitreous floaters, floaterectomy, posterior vitreous detachment

  14. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene;

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of....... The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human...

  15. Formalisation d'annotations produites par des apprenants

    OpenAIRE

    Mille, Dominique

    2005-01-01

    L'objet de cet article est la description d'une formalisation computable des annotations produites par des apprenants, représentée par une ontologie. Cette formalisation explicite la sémantique des annotations grâce à des attributs auxquels le lecteur devrait donner une valeur. Elle contient également les valeurs possibles de ces attributs. L'intérêt d'une telle formalisation est de couvrir toutes les annotations produites par des apprenants, et d'expliciter tout ce qui constitue leur sens, a...

  16. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  17. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

    Directory of Open Access Journals (Sweden)

    Dale Beverly A

    2010-10-01

    Full Text Available Abstract Background Protease-Activated Receptors (PARs, members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs, but the signaling pathways downstream of PAR activation in HOKs have not been clearly defined. In this study, we aimed to determine if PAR1- and PAR2-mediated signaling differs in the induction of innate immune markers CXCL3, CXCL5 and CCL20 via ERK, p38 and PI3K/Akt. Results Our data show the induction of innate immunity by PAR1 requires both p38 and ERK MAP kinases, while PAR2 prominently signals via p38. However, inhibition of PI3K enhances expression of innate immune markers predominantly via suppressing p38 phosphorylation signaled by PAR activation. Conclusion Our data indicate that proteases mediating PAR1 and PAR2 activation differentially signal via MAP kinase cascades. In addition, the production of chemokines induced by PAR1 and PAR2 is suppressed by PI3K/Akt, thus keeping the innate immune responses of HOK in balance. The results of our study provide a novel insight into signaling pathways involved in PAR activation.

  18. Récolte et consommation de pollen par les abeilles

    OpenAIRE

    Odoux, Jean Francois

    2005-01-01

    La récolte de pollen par les abeilles fait appel à des organes spécialisés de l'abeille, comme celle du nectar. Par contre, elle est régie par de très nombreux facteurs, en fonction des ressources, bien sûr, mais aussi des besoins de la colonie, alors que son attractivité n'est pas toujours en rapport avec la qualité. Ce texte décrit le contexte de l'utilisation du pollen par les abeilles, de la récolte à la digestion, d'après une synthèse bibliographique.

  19. La preuve apportée par les sciences

    Directory of Open Access Journals (Sweden)

    1997-04-01

    Full Text Available A propos d´une enquête menée par deux immunologistes de l´Université de Göteborg, rapportée par la très sérieuse revue Nature, le journal Le Monde n´hésitait pas à titrer : " La preuve du sexisme apportée par les sciences ". Les auteurs avaient en effet pu démontrer, irréfutables tests statistiques à l´appui, que, pour obtenir une bourse de post-doctorat offerte par le Swedisch Medical Research Council, les femmes devaient être deux fois et demie plus productives que les hommes ! Nous voulons...

  20. A turquesa de Itacupim, Pará

    Directory of Open Access Journals (Sweden)

    Marcondes Lima da Costa

    2004-12-01

    Full Text Available Na ilha de Itacupim, localizada na região costeira do nordeste do Pará, foram encontrados veios de fosfatos de alumínio contendo turquesa, além de quartzo e argilominerais. A ilha é sustentada por espesso perfil laterítico maturo desenvolvido sobre complexo alcalino-ultramáfico mineralizado em apatita. Os veios e vênulas são de espessura centimétrica, normalmente constituídos de wavellita fibro-radial, onde pode ser observada turquesa verde-azulada, em massas subesferolíticas, microcristalinas, intercrescidas com caulinita e oxi-hidróxidos de Mn, além de quartzo. A identificação mineral foi realizada por DRX, microscopia óptica, análises químicas de rocha total, MEV/SED. Os teores de CuO são inferiores aos das turquesas em geral, compensados por Fe2O3 e ZnO. Os subesferolitos de turquesa contêm inúmeras inclusões micrométricas de goyazita ou svanbergita. A ocorrência da turquesa, na forma de veios e vênulas, seu aspecto porcelanado e a conhecida relação desse mineral com ambiente hidrotermal sugerem que a turquesa de Itacupim também seja de origem hidrotermal, reforçada pela sua associação com wavellita, goyazita ou svanbergita, quartzo e argilominerais. Ela não foi encontrada no perfil laterítico. Seu aspecto compacto e sua cor esverdeada abrem perspectivas para seu uso como mineral de gema.Veins and veinlets of aluminum phosphates with turquoise occur at the Itacupim Island in the coastal plain northeast the state of Pará. A thick mature lateritic iron crust rich in aluminum phosphates developed an apatite-bearing alkaline-ultramafic complex which constitutes the Island. The veins and veinlets are cm-thick, usually constituted by wavellite, fibrous to radialfibrous, with bony or porcelaneous aspect, and can turquoise. Pebbles of these phosphates inside of apatite-bearing ultramafic rocks are very common at the base of the hang wall, and locally form expressive agglomerates. Turquoise forms half spheroids and

  1. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  2. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    processes involve a highly organized interplay between proteases and their cellular binding sites as well as specific substrates and internalization receptors. This review article is focused on two components, the urokinase plasminogen activator receptor (uPAR) and the uPAR-associated protein (uPARAP, also......The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... designated Endo180), that are considered crucially engaged in matrix degradation. uPAR and uPARAP have highly diverse functions, but on certain cell types they interact with each other in a process that is still incompletely understood. uPAR is a glycosyl-phosphatidylinositol-anchored glycoprotein on the...

  3. Pars planitis: Epidemiology, clinical characteristics, management and visual prognosis

    Directory of Open Access Journals (Sweden)

    Pinar Cakar Ozdal

    2015-01-01

    Full Text Available Pars planitis is an idiopathic chronic intermediate uveitis which predominantly affects children and adolescents, and accounts for 5-26.7% of pediatric uveitis. Although an autoimmune process with a genetic predisposition has been suggested, its etiology still remains unknown. The most common presenting symptoms are floaters and blurred vision. Diffuse vitreous cells, haze, snowballs and snowbanks are typical findings of pars planitis. Peripheral retinal vasculitis, optic disc edema and anterior segment inflammation are other well-known findings. Although pars planitis is known to be a benign form of uveitis in most cases, it may become a potentially blinding disease due to complications including cataract, cystoid macular edema, vitreous opacities and optic disc edema. Cystoid macular edema is the most common cause of visual morbidity. Band keratopathy, epiretinal membrane formation, vitreous condensation, neovascularizations, vitreous hemorrhage, retinal detachment, cyclitic membranes, glaucoma and amblyopia may develop as a consequence of the chronic course of the disease. Exclusion of infectious and non-infectious causes which may present with intermediate uveitis is of utmost importance before starting treatment. Treatment of pars planitis has been a controversial issue. There is no consensus specifically for treatment of cases with minimal inflammation and relatively good visual acuity. However, current experience shows that pars planitis may cause severe inflammation and needs an aggressive treatment. A stepladder approach including corticosteroids, immunosupressive agents, anti-tumor necrosis factor-alpha and pars plana vitrectomy and/or laser photocoagulation is the most commonly used method for treatment of pars planitis. Adequate control of inflammation and prompt detection of associated complications are crucial in order to improve the overall prognosis of the disease.

  4. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  5. Par-4 Down-regulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy

    OpenAIRE

    Alvarez, James V.; Pan, Tien-chi; Ruth, Jason; Feng, Yi; Zhou, Alice; Pant, Dhruv; Grimley, Joshua S.; Wandless, Thomas J.; DeMichele, Angela; Chodosh, Lewis A.

    2013-01-01

    Most deaths from breast cancer result from tumor recurrence, but the mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is down-regulated during tumor recurrence and that Par-4 down-regulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor respon...

  6. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  7. Combined pars plana vitrectomy-scleral buckle versus pars plana vitrectomy for proliferative vitreoretinopathy.

    Science.gov (United States)

    Lai, Frank H P; Lo, Ernie C F; Chan, Vesta C K; Brelen, Mårten; Lo, Wai Ling; Young, Alvin L

    2016-04-01

    The purpose of the study is to evaluate the surgical outcomes of combined pars plana vitrectomy-scleral buckle (PPV-SB) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment complicated with proliferative vitreoretinopathy (PVR). One thousand one hundred and seventy four patients with rhegmatogenous retinal detachment surgery between January 2002 and December 2013 were retrospectively reviewed. Patients with grade C PVR treated with either combined PPV-SB or PPV alone were included in the study. Study outcomes included single surgery anatomic success rate and postoperative visual outcome at 12 months postoperatively. Seventy-seven patients with grade C PVR were identified for analysis. At the end of 12-month follow-up, 80.5 % eyes (33/41) in the PPV-SB group and 58.3 % eyes (21/36) in the PPV group achieved single surgery anatomical success. In a multiple logistic regression model, none of the baseline variables (age, gender, macula status, grade of PVR, extent of detachment, presence of vitreous hemorrhage, lens status, status of high myopia) nor types of retinal detachment surgery (use of scleral buckle, barrier endolaser, 360 degree endolaser, cryopexy, retinectomy, tamponade agent, phacoemulsification) had significant effect on single surgery anatomical success. The post-treatment mean logMAR visual acuity of the PPV-SB group was 1.58 ± 0.58 and the PPV group was 1.57 ± 0.61. There was no significant difference in the postoperative visual acuity between the two groups (P = 0.849). For patients with grade C PVR, PPV-SB did not demonstrate a superiority over PPV alone in achieving single surgery anatomical success. PMID:26260357

  8. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  9. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  10. Utilisation de l'essai comete et du biomarqueur gamma-H2AX pour detecter les dommages induits a l'ADN cellulaire par le 5-bromodeoxyuridine post-irradiation

    Science.gov (United States)

    La Madeleine, Carole

    Ce memoire est presente a la Faculte de medecine et des sciences de la sante de l'Universite de Sherbrooke en vue de l'obtention du grade de maitre es sciences (M.Sc.) en radiobiologie (2009). Un jury a revise les informations contenues dans ce memoire. Il etait compose de professeurs de la Faculte de medecine et des sciences de la sante soit : Darel Hunting PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Leon Sanche PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Richard Wagner PhD, membre du programme (departement de medecine nucleaire et radiobiologie) et Guylain Boissonneault PhD, membre exterieur au programme (departement de biochimie). Le 5-bromodeoxyuridine (BrdU), un analogue halogene de la thymidine reconnu depuis les annees 60 comme etant un excellent radiosensibilisateur. L'hypothese la plus repandue au sujet de l'effet radio sensibilisant du BrdU est qu'il augmente le nombre de cassures simple et double brin lorsqu'il est incorpore dans l'ADN de la cellule et expose aux radiations ionisantes. Toutefois, de nouvelles recherches semblent remettre en question les observations precedentes. Ces dernieres etudes ont confirme que le BrdU est un bon radiosensibilisateur, car il augmente les dommages radio-induits dans l'ADN. Mais, c'est en etant incorpore dans une region simple brin que le BrdU radiosensibilise l'ADN. Ces recherches ont egalement revele pour la premiere fois un nouveau type de dommages produits lors de l'irradiation de l'ADN contenant du BrdU : les dimeres interbrins. Le but de ces travaux de recherche est de determiner si la presence de bromodeoxyuridine dans l'ADN augmente l'induction de bris simple et / ou double brin chez les cellules irradiees en utilisant de nouvelles techniques plus sensibles et specifiques que celles utilisees auparavant. Pour ce faire, les essais cometes et la detection des foci H2AX phosphorylee pourraient permettre d'etablir les effets engendres par

  11. OXYDATION DU CYCLOHEXANE PAR COMPLEXE DE RUTHÉNIUM

    OpenAIRE

    HAMOUDI, Badreddine

    2008-01-01

    Le complexe RuCl2(PPh3)3 a été préparé dans le but de son application sur la réaction d’oxydation du cyclohexane en cyclhexanol et cyclohexanone. Les analyses par chromatographie en phase gaz sur la phase organique montrent la production de l’alcool et la cétone dans le cas du t-BuOOH comme oxydant, ce qui n’est le cas avec l’eau oxygénée et l’oxygène moléculaire. La réaction a été effectuée dans différents solvants, où l’eau a apportée une meilleure conversion par rapport a...

  12. CFD Application to Hydrogen Risk Analysis and PAR Qualification

    Directory of Open Access Journals (Sweden)

    Jinbiao Xiong

    2009-01-01

    Full Text Available A three dimensional computation fluid dynamics (CFD code, GASFLOW, is applied to analyze the hydrogen risk for Qinshan-II nuclear power plant (NPP. In this paper, the effect of spray modes on hydrogen risk in the containment during a large break loss of coolant accident (LBLOCA is analyzed by selecting three different spray strategies, that is, without spray, with direct spray and with both direct and recirculation spray. A strong effect of spray modes on hydrogen distribution is observed. However, the efficiency of the passive auto-catalytic recombiners (PAR is not substantially affected by spray modes. The hydrogen risk is significantly increased by the direct spray, while the recirculation spray has minor effect on it. In order to simulate more precisely the processes involved in the PAR operation, a new PAR model is developed using CFD approach. The validation shows that the results obtained by the model agree well with the experimental results.

  13. Terapia Miofuncional en pacientes con parálisis cerebral

    OpenAIRE

    Gónzalez Amigo, José

    2015-01-01

    En el presente trabajo, se va a llevar a cabo una visión de la parálisis cerebral desde el punto de vista de la motricidad. La parálisis cerebral es una patología que se caracteriza fundamentalmente por una alteración a nivel motriz, que puede afectar a las diferentes extremidades así como a los órganos involucrados en el habla. Estas limitaciones en la región orofacial pueden producir importantes distorsiones y como consecuencia el discurso puede resultar ininteligible para los interlocutore...

  14. La parálisis cerebral en el cine

    OpenAIRE

    Merino Marcos, María Lucila

    2005-01-01

    [ES] En los últimos veinticinco años se han rodado un número importante de películas en las que el protagonista o algún personaje secundario presentaban o simulaban una parálisis cerebral. Estos personajes en ocasiones han sido interpretados por personas con minusvalías. En la narración de su historia las cintas han incluido diversos aspectos sanitario-asistenciales, sociales y familiares obligados en el campo de la parálisis cerebral. [EN] In the last twenty-five years, a number of import...

  15. Apprentissage par Renforcement Développemental en Robotique Autonome

    OpenAIRE

    Sarzyniec, Luc; Buffet, Olivier; Dutech, Alain

    2011-01-01

    National audience Cet article présente une approche développementale de l'apprentissage par renforcement dans un cadre de robotique autonome. Le but est de permettre au robot de tirer parti de la richesse de son environnement sans que cette richesse ne le noie sous trop d'information à traiter. L'idée principale testée ici est de faire croître les capacités perceptives et motrices de l'agent au fur et à mesure de l'apprentissage. Cette approche est combinée avec un apprentissage par renfor...

  16. Ejercicios activos en la parálisis facial

    OpenAIRE

    Bohoyo Aramburu, Cristina

    2013-01-01

    Diseño: Se trata de una revisión bibliográfica en la que se incluyen revisiones sistemáticas y artículos sobre el tratamiento de la parálisis facial mediante ejercicios faciales, que en su conjunto engloban lo que se denomina la “mímicoterapia”. Objetivos: el objetivo principal es determinar la eficacia de los ejercicios faciales activos en el tratamiento de la parálisis de Bell. El objetivo secundario es describir dichos ejercicios. Métodos: se ha realizado una búsqueda mediante la base d...

  17. Cyclanthaceae no estado do Pará, Brasil Cyclanthaceae in Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo da Silva Leal

    2012-12-01

    Full Text Available Cyclanthaceae apresenta distribuição exclusiva na região neotropical sendo bem diversificada nas terras baixas das florestas pluviais tropicais, ocorrendo do sul do México até a Mata Atlântica do sul do Brasil. Consistem de ervas terrestres, epífitas, hemiepífitas ou lianas. O tratamento taxonômico de Cyclanthaceae no Pará foi baseado em coleções de herbário, trabalhos de campo e consulta a bibliografia referente à família. Foram registradas 11 espécies: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. e Thoracocarpus bissectus (Vell. Harling. São apresentadas chave de identificação, descrições e ilustrações das espécies, além de comentários sobre distribuição geográfica, hábitat e período de floração e frutificação.Cyclanthaceae is a family with a distribution exclusively in the Neotropics and is well diversified in lowland rainforests, occurring from southern Mexico to the Atlantic Forest of southern Brazil. The family consists of terrestrial herbs, epiphytes, hemiepiphytes and lianas. This taxonomic treatment of the Cyclanthaceae from the state of Pará was based on herbarium specimens, fieldwork, and the literature. Eleven species were recorded: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. and Thoracocarpus bissectus (Vell. Harling. An identification key, descriptions and illustrations of species are presented. Additional information on the geographic distribution, habitat, and flowering and

  18. Humorale, endotheliale und mechanische Faktoren der Vasoregulation – Detektion neuer Systeme und therapeutische Beeinflussbarkeit

    OpenAIRE

    Timm H Westhoff

    2010-01-01

    The regulation of vasomotor tone is mediated by a dynamic interplay of various local and systemic parameters. Imbalances in this complex system may play a role in the pathogenesis of hypertension. The first part of the present work describes the identification and pharmacological characterization of new humoral vasoactive substances and the search for new differentially expressed blood pressure regulating genes. The second part describes clinical trials on the measurement of arterial function...

  19. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    Directory of Open Access Journals (Sweden)

    César Moreira Sampaio

    2001-06-01

    Full Text Available Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecções, na grande maioria, tiveram localização pré-septal (94,2%. As hemoculturas, realizadas em 21 pacientes, resultaram em 71% de negatividade, seguido por positividade para S. aureus (19%, H. influenzae (4,7% e flora mista (4,7%. Todos os pacientes foram tratados e curados com antibioticoterapia utilizando 16 quimioterápicos em 25 diferentes esquemas terapêuticos. A drenagem cirúrgica foi realizada em apenas 7 pacientes. Conclusão: A despeito da falta de uniformidade e diversidade de esquemas terapêuticos empregados nos casos estudados e da falta de avaliação oftalmológica na maioria dos casos, os pacientes foram curados sem complicações. Tal fato indica a necessidade de estudos prospectivos que visem a elaboração de protocolo terapêutico para as celulites da região orbitária na infância, que leve em consideração a relação custo-benefício positiva.Purpose: Retrospective study of clinical and therapeutic aspects in children with orbital and preseptal cellulitis. Methods: Fifty-two records of patients admitted at the São Rafael Hospital between 1990 and 1998 were reviewed. The age of the patients ranged from one month to twelve years. Based on a protocol elaborated by the authors the following aspects were analyzed: age, sex, predisposing factors, localization of the cellulitis in the orbital region, clinical, laboratorial and image findings as well as the clinical or surgical therapy and the occurrence of complications

  20. Problemes methodologiques poses par l'extraction et la recuperation des bacteries telluriques pour leur quantification par immunofluorescence

    OpenAIRE

    Crozat, Y.; Cleyet-Marel, Jean Claude

    1984-01-01

    Afin d’améliorer la valeur quantitative de la technique de dénombrement des bactéries telluriques (Rhizobium japonicum) par immunofluorescence, on compare différents modes d’extraction et de récupération. L’utilisation de membranes en polycarbonates (Nucléopores) supprime les 40 p. 100 de pertes occasionnées par les membranes cellulosiques (Millipores) classiquement employées. Parmi les différents floculants testés, Ca(OH)2/MgCO3(2/5) permet d’obtenir les meilleurs résultats. Cependant po...

  1. Limitation des populations de ravageurs de l’olivier par le recours à la lutte biologique par conservation

    OpenAIRE

    Warlop, Francois

    2006-01-01

    L’olivier est une culture relativement rustique, mais qui peut être fortement attaquée par la mouche Bactrocera oleae (Gmelin), son principal ravageur. Les parasitoïdes de cette mouche sont connus, mais leur impact sur les populations de Diptères demeure faible, faute d’aménagement adéquat du paysage et suite à une intensification abusive des pratiques culturales. Le programme d’installation de bandes florales mené par le Groupe de recherches en agriculture biologique qui a débuté en 2004 vis...

  2. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    DEFF Research Database (Denmark)

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric binding...... inhibitory effect of beta-galactosidase. Analyses of 125I-IGF-II binding curves in the presence of beta-galactosidase or D-mannose 6-phosphate demonstrated that none of these compounds changed the binding affinity of 125I-IGF-II for the membrane vesicles. The IGF-II/M6P receptor content in the luminal...

  3. PH motifs in PAR1&2 endow breast cancer growth.

    Science.gov (United States)

    Kancharla, A; Maoz, M; Jaber, M; Agranovich, D; Peretz, T; Grisaru-Granovsky, S; Uziely, B; Bar-Shavit, R

    2015-01-01

    Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Here we show signal-binding motifs in PAR1&2 that are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26600192

  4. Par Pond vegetation status summer 1995 - July survey descriptive summary

    International Nuclear Information System (INIS)

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond

  5. Radiative Transfer Code: Application to the calculation of PAR

    Indian Academy of Sciences (India)

    D Emmanuel; D Phillippe; C Malik

    2000-12-01

    The production of carbon in the ocean, the so-called primary production, depends on various physico- biological parameters: the biomass and nutrient amounts in oceans, the salinity and temperature of the water and the light available in the water column. We focus on the visible spectrum of the solar radiation defined as the Photosynthetically Active Radiation (PAR). We developed a model (Chami et al. 1997) to simulate the behavior of the solar beam in the atmosphere and the ocean. We first describe the theoretical basis of the code and the method we used to solve the radiative transfer equation (RTE): the successive orders of scattering (SO). The second part deals with a sensitivity study of the PAR just above and below the sea surface for various atmospheric conditions. In a cloudy sky, we computed a ratio between vector fluxes just above the sea surface and spherical fluxes just beneath the sea surface. When the optical thickness of the cloud increases this ratio remains constant and around 1.29. This parameter is convenient to convert vector flux at the sea surface as retrieved from satellite to PAR. Subsequently, we show how solar radiation as vector flux rather than PAR leads to an underestimate of the primary production up to 40% for extreme cases.

  6. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine;

    2011-01-01

    Degradation of proteins in the extracellular matrix is crucial for the multistep process of cancer invasion and metastasis. Compelling evidence has demonstrated the urokinase receptor (uPAR) and its cognate ligand, the urokinase plasminogen activator (uPA), to play critical roles in the concerted...

  7. Radiological impact of Par Pond drawdown from liquid effluent pathways

    International Nuclear Information System (INIS)

    The water level of Par Pond has been lowered over the past several months to reduce the effects in the event of catastrophic dam failure while assessing the condition of the dam and determining if repairs are necessary. In lowering the level of Par Pond, 60 billion liters of water containing low levels of tritium and cesium-137 were discharged to several onsite streams. SRS surface streams flow to the Savannah River. An assessment made to determine the total amount of tritium and Cs-137 discharged and to estimate the consequences to downstream Savannah River users. It is estimated that a total of 160 curies of tritium were displaced from Par Pond to the Savannah River between June 28, 1991 and September 19, 1991. This release could hypothetically result in a maximum individual dose of 3. 2x10-4 mrem and a total (80-km and drinking water populations) population dose of 1.4x10-2 person-rem. Likewise, a maximum individual dose of 5.0x10-2 mrem and a total population dose of 1.7x10-1 person- rem are predicted as a result of an estimated 0.21 curies of Cs-137 being discharged from Par Pond to the Savannah River

  8. Pollution par les nitrates: quels remèdes?

    OpenAIRE

    Zilliox, Lothaire; Schenck, Charles; Kobus, Helmut; Huwe, Bernd

    1990-01-01

    Au cours des dix dernières années, la pollution des eaux souterraines par les nitrates n'a cessé d'augmenter. Principale accussée: l'agriculture, l'application de méthodes de techniques culturales devrait permettre une meilleure gestion des engrais azotés.

  9. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015). ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  10. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  11. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...

  12. Development of quantitative RT-PCR assays for wild-type urokinase receptor (uPAR-wt) and its splice variant uPAR-del5

    International Nuclear Information System (INIS)

    The receptor for the serine protease urokinase-type plasminogen activator, uPAR (CD 87), plays an important role in tumor cell invasion and metastasis of solid malignant tumors. uPAR is a highly glycosylated, glycan lipid-anchored membrane protein, consisting of three homologous domains. Each individual domain is encoded by two exons: DI by exons 2+3, DII by exons 4+5, and DIII by exons 6+7. Beside the wild-type (wt) uPAR mRNA, two splice variants either lacking exon 5 (uPAR-del5) or both exons 4 and 5 (uPARdel4/ 5) have been described. Previously, we studied expression of the mRNA variant uPAR-del4/5 and uPAR mRNA encompassing exons 2, 3, and 4 (i.e. uPAR-wt plus uPAR-del5) applying real-time RT-PCR assays for quantification of the mRNA concentration. In the present paper, we established two additional specific, robust and highly sensitive RT-PCR assays, based on the LightCycler technology, to specifically quantify either uPAR-wt or its splice variant, uPARdel5. Expression of uPAR-wt and uPAR-del5 was analyzed in different human malignant cell lines (ovarian cancer cell lines OVMZ-6 and OVMZ-10; breast cancer cell lines MDA-MB 231, MDA-MB 231 BAG, MDA-MB 435, and aMCF-7; brain tumor cell line LN 18) as well as in a set of 174 breast cancer tissue samples. uPAR-del5 mRNA was found to be expressed very frequently at a rather low level (typically less than 1% of uPAR-wt mRNA). In tumor tissue from breast cancer patients, a statistically significant correlation between uPAR-del5 and uPAR-wt mRNA (r = 0.779; P < 0.001) was observed. There was no association between the expression level of either mRNA and clinical parameters such as nodal status, tumor size and grade. In estrogen receptor negative tumors, a significantly higher uPAR-del5 expression was found (P 0.023). The two developed quantitative RT-PCR assays described here may aid further analysis of the function and clinical relevance of uPAR-wt and one of its splice variants, uPAR-del5, in malignant tumors

  13. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    OpenAIRE

    Anna Gustafsson; Vjosa Ajeti; Lennart Ljunggren

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to ...

  14. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    Science.gov (United States)

    Gustafsson, Anna; Ajeti, Vjosa; Ljunggren, Lennart

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to plasma suPAR, CRP, BMI, or gender. Blood and unstimulated whole saliva was collected from 20 healthy individuals (10 female and 10 male, median age of 28 years; range 21–41). CRP and suPAR were measured with ELISA in saliva and serum/plasma. suPAR was detected in all saliva samples in the 5.2–28.1 ng/mL range, with a median value of 17.1 ng/mL. Saliva suPAR was significantly higher (P < 0.001) but not correlated to plasma suPAR in healthy young adults with normal plasma suPAR levels. suPAR and CRP levels were correlated in blood but not in saliva. No correlation was found between BMI, age, or gender and suPAR in saliva. PMID:22084570

  15. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    DEFF Research Database (Denmark)

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.;

    2008-01-01

    identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...

  16. ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

    Science.gov (United States)

    The small serine resolvase ParA from bacterial plasmids RK2 and RP4 catalyzes the recombination of two identical 133 bp recombination sites known as MRS. Previously, we reported that ParA is active in the fission yeast Schizosaccharomyces pombe. In this work, the parA recombinase gene was placed un...

  17. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi

    NARCIS (Netherlands)

    J.W.R. Hovius; M.F. Bijlsma; G.J.W. van der Windt; W.J. Wiersinga; B.J.D. Boukens; J. Coumou; A. Oei; R. de Beer; A.F. de Vos; C. van 't Veer; A.P. van Dam; P. Wang; E. Fikrig; M.M. Levi; J.J.T.H. Roelofs; T. van der Poll

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also

  18. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob;

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA...

  19. Is There an "F" in Your PAR? Understanding, Teaching and Doing Action Research

    Science.gov (United States)

    Lorenzetti, Liza; Walsh, Christine Ann

    2014-01-01

    Participatory Action Research (PAR) is increasingly recognized within academic research and pedagogy. What are the benefits of including feminism within participatory action research and teaching? In responding to this question, we discuss the similarities and salient differences between PAR and feminist informed PAR (FPAR). There are eight themes…

  20. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    with a single plasmid focus, the focus located preferentially at mid-cell. In cells with two foci, these located at quarter-cell positions. In the absence of ParB and parC1/parC2, ParA-GFP formed stationary helices extending from one end of the nucleoid to the other. In the presence of ParB and parC1/parC2, ParA-GFP......The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells...... oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...

  1. Des guides touristiques pour le peuple et par le peuple

    Directory of Open Access Journals (Sweden)

    Ninon Vinsonneau

    2006-04-01

    Full Text Available Le Federal Writers’ Project (FWP constitua l’un des quatre programmes « culturels » lancés par l’administration du New Deal en 1935 en vue de résorber le problème du chômage parmi les professions dites « en col blanc ». Il employa de 1935 à 1943, entre quatre et six mille chômeurs par an, tous membres des « professions de l’écrit » — les « écrivains », au sens large que l’administration fédérale donnait à ce terme : romanciers, poètes, dramaturges, mais aussi journalistes, enseignants, cherc...

  2. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  3. Diffusion d'un champ electromagnetique par un batiment modelise

    OpenAIRE

    Bourrely, Claude

    2008-01-01

    Cette étude présente la diffusion d'un champ électromagnétique par un batiment de bureaux modélisé suivant un réseau bipériodique, en particulier, l'objectif est de calculer le champ réfléchi et transmis. Ce champ est produit par une antenne extérieure au batiment, on suppose qu'elle émet une onde plane. On travaille dans un domaine de longueur d'onde qui est inférieur à la plus petite dimension de la structure, ce qui correspond à l'épaisseur des murs. Les calculs sont effectués suivant la m...

  4. Valorisation de biogaz pour industrie chimie par voie catalytique

    OpenAIRE

    Taimoor, Aqeel Ahmad

    2010-01-01

    La production de l'hydrogène à partir de biomasse est actuellement à l'étude mais la méthode de valorisation du biogaz (mélange H2/CO2) par réactions catalytiques, autres que la simple combustion, n'a pas encore été retenue. Par conséquent, le principal objectif de ce travail est d'explorer les autres voies. L'effet du CO2 sur le système catalytique est mal connu et seulement un effet négatif sur la dissociation de l'hydrogène a été mentionné. L'hydrogénation du toluène sur un catalyseur Pt a...

  5. Acute hypocomplementemic post-infectious glomerulonephritis as a complication of sinus-related orbital cellulitis: case report Glomerulonefrite pós-infecciosa hipocomplementêmica aguda como complicação de celulite orbitária relacionada aos seios paranasais: relato de caso

    OpenAIRE

    Jayter Silva Paula; Antonio Augusto Velasco e Cruz; Patrícia Mitiko Santelo Akaishi; Tiana Burman

    2008-01-01

    Group A beta-hemolytic streptococcus is the most common agent implicated in post-infectious acute glomerulonephritis. We report a case of acute poststreptococcal glomerulonephritis associated with sinus-related orbital abscess in an 11-year-old boy treated with surgical drainage and intravenous ceftriaxone and clindamycin. Twelve days after supportive measures, renal function was normalized. We also discuss this potentially severe nonsuppurative complication of orbital cellulitis caused by gr...

  6. L'exraction par micro-ondes: un choix de qualité

    OpenAIRE

    Ramdani, M.; Ghazi, Z.; Fadel, O.; Mouni, L.; Wathelet, Jean-Paul

    2010-01-01

    Le but de ce travail est de comparer l’extraction faite par chauffage classique (CC) avec celle réalisée sous micro-ondes (MO). Deux modes d’extraction ont été réalisés : - L’hydro-distillation par chauffage classique (extraction par entraînement à la vapeur d’un solvant) et, - L’hydro-distillation activée par micro-ondes. Les MO permettent un gain de temps considérable. Par exemple, dans le cas du lavandula dentata : on note une cinétique 3 fois plus rapide, de plus le rendement ...

  7. ASPECTS NUTRITIONNELS DES ACIDES GRAS POLYINSATURES n-3 Augmentation sélective de la sensibilité des tumeurs à la chimiothérapie par les acides gras polyinsaturés n-3

    Directory of Open Access Journals (Sweden)

    Bougnoux Philippe

    2000-01-01

    Full Text Available L’alimentation intervient à différents niveaux dans le déroulement de la maladie cancéreuse : au niveau du risque [1] et au niveau de l’évolution en modifiant le risque de survenue des métastases. L’alimentation influence-t-elle aussi la réponse aux traitements anticancéreux ? À l’appui de cette hypothèse viennent deux observations indirectes réalisées dans le cancer du sein : nos données [2, 3] ainsi que les observations épidémiologiques provenant d’autres travaux [4] ont apporté des arguments supportant l’hypothèse que les lipides alimentaires peuvent influencer la réponse des tumeurs mammaires aux traitements. On sait que la composition des lipides membranaires n’est pas génétiquement déterminée, mais qu’elle dépend des acides gras disponibles aux tissus périphériques. Le type d’acides gras disponibles est influencé par les apports alimentaires. Comme les tumeurs incorporent dans leurs lipides les acides gras disponibles de façon similaire aux autres tissus [5], il est plausible que les habitudes alimentaires (apports alimentaires en acides gras polyinsaturés, vitamines anti ou pro-oxydantes puissent influencer leur chimiosensibilité en apportant aux cellules tumorales des substrats de peroxydation.

  8. MetaPar: Metagenomic Sequence Assembly via Iterative Reclassification

    OpenAIRE

    Kim, MinJi; Ligo, Jonathan G.; Emad, Amin; Farnoud, Farzad; Milenkovic, Olgica; Veeravalli, Venugopal V.

    2013-01-01

    We introduce a parallel algorithmic architecture for metagenomic sequence assembly, termed MetaPar, which allows for significant reductions in assembly time and consequently enables the processing of large genomic datasets on computers with low memory usage. The gist of the approach is to iteratively perform read (re)classification based on phylogenetic marker genes and assembler outputs generated from random subsets of metagenomic reads. Once a sufficiently accurate classification within gen...

  9. Design Studies and Commissioning Plans for PARS Experimental Program

    OpenAIRE

    Mete, O.; Hanahoe, K.; G. Xia; Dover, M.; Wigram, M.; Wright, J.; Zhang, J.; Smith, J.

    2015-01-01

    PARS (Plasma Acceleration Research Station) is an electron beam driven plasma wakefield acceleration test stand proposed for VELA/CLARA facility in Daresbury Laboratory. In order to optimise various operational configurations, 2D numerical studies were performed by using VSIM for a range of parameters such as bunch length, radius, plasma density and positioning of the bunches with respect to each other for the two-beam acceleration scheme. In this paper, some of these numerical studies and co...

  10. Design Studies and Commissioning Plans for PARS Experimental Program

    CERN Document Server

    Mete, O; Xia, G; Dover, M; Wigram, M; Wright, J; Zhang, J; Smith, J

    2015-01-01

    PARS (Plasma Acceleration Research Station) is an electron beam driven plasma wakefield acceleration test stand proposed for VELA/CLARA facility in Daresbury Laboratory. In order to optimise various operational configurations, 2D numerical studies were performed by using VSIM for a range of parameters such as bunch length, radius, plasma density and positioning of the bunches with respect to each other for the two-beam acceleration scheme. In this paper, some of these numerical studies and considered measurement methods are presented.

  11. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    OpenAIRE

    Mutoh T; Kadoya K; Chikuda M

    2012-01-01

    Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females) after 25-gauge pars plana vitrectomy (PPV). One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedu...

  12. «La Promenade par les aventures surprenants»

    OpenAIRE

    Duarte, Alexandre Freire

    2010-01-01

    É nossa intenção, neste estudo, focar a atenção heurística no par: Jean-Joseph Surin (1600-1665), e Michel de Certeau, um homem que, intermitentemente – revelando uma vida queimada pelo fascínio por Jean-Joseph Surin –, constituiu, nas nossas mãos atentamente vazias, num vasto arvoredo que nos remetia continuamente para uma sombria clareira luminosa que irradiava do meio daquele.

  13. Taare Zameen Par and dyslexic savants

    OpenAIRE

    Chakravarty Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were ...

  14. The ParMol package for frequent subgraph mining

    OpenAIRE

    Meinl, Thorsten; Wörlein, Marc; Urzova, Olga; Fischer, Ingrid; Philippsen, Michael

    2006-01-01

    Mining for frequent subgraphs in a graph database has become a popular topic in the last years. Algorithms to solve this problem are used in chemoinformatics to find common molecular fragments in a database of molecules represented as two-dimensional graphs. However; the search process in arbitrary graph structures includes costly graph and subgraph isomorphism tests. In our ParMol package we have implemented four of the most popular frequent subgraph miners using a common infrastructure: MoF...

  15. Pars Plana Vitrectomy and Intravitreal Phacoemulsification for Dropped Nuclei

    OpenAIRE

    Khalil Ghasemi Falavarjani; Masih Hashemi; Ali Jalili Fazel; Mehdi Modarres; Hossein Nazari; Mohammad-Mehdi Parvaresh

    2012-01-01

    Purpose: To report the outcomes of pars plana vitrectomy (PPV) and intravitreal phacoemulsification in patients with dropped nuclei/nuclear fragments following complicated cataract surgery. Methods: In this retrospective case series, charts of patients who had undergone PPV and intravitreal phacoemulsification for removal of dislocated nuclei/lens fragments were reviewed. After standard PPV, a conventional phacoemulsification probe with an amputated sleeve was used for grasping and emulsi...

  16. Results of pars plana vitrectomy after complicated phacoemulsification surgery

    OpenAIRE

    Alexandre Grandinetti; Diogo Suenaga; Fernanda M. Oliveira; Krissis Saliba Uliana Cruz; Laurinda Meneguette; Luciane Bugman Moreira

    2015-01-01

    Purpose: To identify the causes and outcomes of pars plana vitrectomy (PPV) in patients undergoing phacoemulsification with intraoperative complication and to analyze whether the interval between phacoemulsification and PPV interferes with best-corrected final visual acuity. Methods: This descriptive and retrospective analytical study was conducted in Paraná Eye Hospital in 2013. Data were collected from medical records of 38 patients who underwent complicated phacoemulsification and also req...

  17. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH2, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  18. Diagnostic Ultrasound and Pars Plana Vitrectomy in Endophthalmitis

    Institute of Scientific and Technical Information of China (English)

    Jingjing Huang; Zhenfang Wang; Lijuan Zou; Xiaofeng Lin; Yiwen Luo; Zhaohui Yuan

    2004-01-01

    Purpose: To compare the results by B-scan ultrasonography and findings in pars plana vitrectomy, and assess the diagnostic value of B-scan ultrasonography in endophthalmitis.Methods: Thirty eyes of 30 subjects diagnosed as endophthalmitis were selected, who undergone preoperative B-scan ultrasonography. The result of pars plana vitrectomy was recorded. The above two results were compared.Results: On the evaluation of vitreous and retinal states in the patients with endophthalmitis, the sensitivity of ultrasound was 90%~100%, and the specificity was 79%~100%.Poorer preoperative visual acuity was related with retinal detachment and retinal dissolution. The preoperative visual acuity in eyes with local vitreous opacity was better than with diffuse vitreous opacity.Conclusion: Comparison of the results of B-scan ultrasonography and the findings in pars plana vitrectomy showed B-scan ultrasonography is highly sensitive, specific, and is very helpful in the evaluation of endophthalmitis. B-scan ultrasonography can not only supply much information in the diagnosis of endophthalmitis but also inspect its trends and changes, which is helpful in the selection of treatment and planning the time of surgery.

  19. ParB Partition Proteins: Complex Formation and Spreading at Bacterial and Plasmid Centromeres.

    Science.gov (United States)

    Funnell, Barbara E

    2016-01-01

    In bacteria, active partition systems contribute to the faithful segregation of both chromosomes and low-copy-number plasmids. Each system depends on a site-specific DNA binding protein to recognize and assemble a partition complex at a centromere-like site, commonly called parS. Many plasmid, and all chromosomal centromere-binding proteins are dimeric helix-turn-helix DNA binding proteins, which are commonly named ParB. Although the overall sequence conservation among ParBs is not high, the proteins share similar domain and functional organization, and they assemble into similar higher-order complexes. In vivo, ParBs "spread," that is, DNA binding extends away from the parS site into the surrounding non-specific DNA, a feature that reflects higher-order complex assembly. ParBs bridge and pair DNA at parS and non-specific DNA sites. ParB dimers interact with each other via flexible conformations of an N-terminal region. This review will focus on the properties of the HTH centromere-binding protein, in light of recent experimental evidence and models that are adding to our understanding of how these proteins assemble into large and dynamic partition complexes at and around their specific DNA sites. PMID:27622187

  20. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob;

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...... the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  1. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  2. Validation of MODIS and GEOV1 fPAR Products in a Boreal Forest Site in Finland

    Directory of Open Access Journals (Sweden)

    Titta Majasalmi

    2015-01-01

    Full Text Available Remote sensing of the fraction of absorbed Photosynthetically Active Radiation (fPAR has become a timely option to monitor forest productivity. However, only a few studies have had ground reference fPAR datasets containing both forest canopy and understory fPAR from boreal forests for the validation of satellite products. The aim of this paper was to assess the performance of two currently available satellite-based fPAR products: MODIS fPAR (MOD15A2, C5 and GEOV1 fPAR (g2_BIOPAR_FAPAR, as well as an NDVI-fPAR relationship applied to the MODIS surface reflectance product and a Landsat 8 image, in a boreal forest site in Finland. Our study area covered 16 km2 and field data were collected from 307 forest plots. For all plots, we obtained both forest canopy fPAR and understory fPAR. The ground reference total fPAR agreed better with GEOV1 fPAR than with MODIS fPAR, which showed much more temporal variation during the peak-season than GEOV1 fPAR. At the chosen intercomparison date in peak growing season, MODIS NDVI based fPAR estimates were similar to GEOV1 fPAR, and produced on average 0.01 fPAR units smaller fPAR estimates than ground reference total fPAR. MODIS fPAR and Landsat 8 NDVI based fPAR estimates were similar to forest canopy fPAR.

  3. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  4. Monitoreo de parásitos en efluentes domiciliarios

    OpenAIRE

    Liliana Semenas; Norma Brugni; Gustavo Viozzi; Ana Kreiter

    1999-01-01

    OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente ...

  5. Inspecciones París MOU y normas reguladoras

    OpenAIRE

    Díaz Pujol, María del Carmen

    2013-01-01

    Este proyecto trata fundamentalmente del control del Estado rector del puerto que desarrollan los Estados miembros del Memorando de París. El texto se compone de cinco capítulos a lo largo de los que se abordan las siguientes cuestiones: El capítulo primero da un repaso a la importancia que revisten las normas sobre seguridad marítima y prevención de la contaminación marina, a la vez que expone la cuestión relativa a la responsabilidad de su aplicación y de su cumplimiento, recordando q...

  6. Alex: incluir la parálisis cerebral

    OpenAIRE

    Ayuela Fernández, Mª del Mar

    2013-01-01

    El presente trabajo se basa en un estudio de caso: Alex. Un niño con una parálisis cerebral tipo espástico y su inclusión, bajo el proceso de enseñanza-aprendizaje durante el curso 2012-2013 en dos escenarios: familia y colegio. En un primer momento señalaremos los objetivos planteados a raíz de los interrogantes que nos suscita el trabajar con niños y niñas con necesidades educativas especiales. Posteriormente y tras un encuadre teórico y metodológico, abordaremos una propuesta de intervenci...

  7. Videojuego adaptado para personas con parálisis cerebral

    OpenAIRE

    Gómez Davó, Roberto

    2014-01-01

    La parálisis cerebral describe un grupo de trastornos del desarrollo psicomotor, que causan una limitación de la actividad de la persona, es decir, es un padecimiento que principalmente se caracteriza por la inhabilidad de poder controlar completamente las funciones del sistema motor. Esto puede incluir espasmos o rigidez en los músculos, movimientos involuntarios, y/o trastornos en la postura o movilidad del cuerpo. Estos trastornos psicomotores imposibilitan su interacción con los sistemas ...

  8. INCORPORATION DU PHOSPHORE DANS CdTe PAR RECUIT LASER

    OpenAIRE

    Uzan, C.; Legros, R.; Marfaing, Y.

    1983-01-01

    La méthode du recuit laser a été utilisée pour incorporer du phosphore dans CdTe à partir d'une couche de Cd3P2 déposée en surface. La caractérisation par photoluminescence et mesure de profil à l'analyseur ionique montre le caractère actif du phosphore introduit et permet d'évaluer à 1018cm-3 la concentration atteinte à 1 µm de profondeur.

  9. INNOVATIONS ET GOUVERNANCE TERRITORIALE : UNE ANALYSE PAR LES DISPOSITIFS

    OpenAIRE

    Soulard, Christophe-Toussaint; Mathé, Syndhia; Michel, Laura; Nougaredes, Brigitte; Jarrige, Françoise; Maurel, Pierre; Clement, Camille; Martinand, Pierre; Guiheneuf, Pierre-Yves; Barbe, Eric

    2010-01-01

    Cette communication vise à présenter les outils méthodologiques d’analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s’agit d’étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dans un contexte de recomposi...

  10. Innovation et gouvernance territoriale : une analyse par les dispositifs

    OpenAIRE

    Rey Valette, H.; Chia, E; Soulard, C.; Mathé, S.; Michel, L.; Nougaredes, B.; Jarrige, F.; Maurel, P.; Clement, C.; Martinand, P.; Guiheneuf, P.Y.; Barbe, E.

    2010-01-01

    International audience Cette communication vise à présenter les outils méthodologiques d'analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s'agit d'étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dan...

  11. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  12. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All ...... simultaneously abolished plasmid stabilization and ParA-Gfp oscillation. These observations raise the possibility that ParA oscillation is prerequisite for active plasmid segregation.......Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...... Type II locus. Separately, each locus stabilized a test-plasmid efficiently. Together, the two loci mediated even more efficient plasmid stabilization. The par loci have a unique genetic organization in that they share a common central region at which the two different DNA-binding proteins probably act...

  13. Localization of the ParC protein in Escherichia coli cells

    OpenAIRE

    2007-01-01

    The Escherichia coli ParC protein is one of two subunits of the topoisomerase IV, a type II topoisomerase. Topo IV is responsible for relaxing positive supercoils and decatenating linked daughter chromosomes after replication. This is done by introducing transient double-stranded breaks into the DNA, passing through a segment of uncut duplex DNA, before resealing the break. Mutations in parC lead to the par phenotype which is characterized by chromosomes that can replicate but are deficient i...

  14. Utilisation rationnelle de l'énergie par les techniques de stockage et de transport du froid par chaleur latente

    OpenAIRE

    Bédécarrats, Jean-Pierre

    2010-01-01

    Les contraintes environnementales de plus en plus fortes ainsi que les problèmes grandissants de la disponibilité des ressources énergétiques obligent le secteur de l'énergie non seulement à une évolution importante de ses technologies mais aussi à leurs utilisations plus rationnelles. Ce mémoire présente la synthèse de mes initiatives de recherches menées sur le stockage et le transport de l'énergie par chaleur latente essentiellement dans le domaine du froid. Les Matériaux à Changement de P...

  15. Stress reactions involving the pars interarticularis in young athletes

    International Nuclear Information System (INIS)

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  16. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Directory of Open Access Journals (Sweden)

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  17. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) has been shown to be of special importance during cancer invasion and metastasis. However, currently, tissue samples are needed for measurement of uPAR expression limiting the potential as a clinical routine. Therefore, non-invasive methods are...... the cell surface. Due to the importance of uPAR in cancer invasion and metastasis, a number of high-affinity ligands have been identified during the last decades. These ligands have recently been used as starting point for the development of a number of ligands for imaging of uPAR using various...

  18. Structural and genetic analyses of a par locus that regulates plasmid partition in Bacillus subtilis.

    OpenAIRE

    Chang, S.; Chang, S Y; Gray, O

    1987-01-01

    The Bacillus plasmid pLS11 partitions faithfully during cell division. Using a partition-deficient plasmid vector, we randomly cloned DNA fragments of plasmid pLS11 and identified the locus that regulates plasmid partition (par) by cis complementation in Bacillus subtilis. The cloned par gene conferred upon the vector plasmid a high degree of segregational stability. The par locus was mapped to a 167-base-pair segment on pLS11, and its nucleotide sequence was determined. The cloned par fragme...

  19. Le diagnostic anténatal de la trisomie 21 par l'hybridation in situ en fluorescence (FISH): à propos des premiers tests réalisés au Maroc

    Science.gov (United States)

    Lamzouri, Afaf; Natiq, Abdelhafid; Tajir, Mariam; Sendid, Mohamed; Sefiani, Abdelaziz

    2012-01-01

    Introduction Le but de cette étude était de présenter les premiers résultats de diagnostic anténatal de la trisomie 21 par la technique d'hybridation in situ en fluorescence (FISH) au Maroc et discuter son intérêt dans le diagnostic rapide de cette aneuploïdie. Méthodes Ce travail a été réalisé chez 23 femmes avec des grossesses à haut risque de trisomie 21. La moyenne d’âge des gestantes étaient de 37,43 ans avec des extrêmes de 21 et 43 ans. Toutes étaient musulmanes mariées, mariage légitimé par la Charia, dont trois mariages consanguins, sauf une originaire de la République Démocratique du Congo qui était chrétienne et concubine. La majorité des femmes étaient fonctionnaires et avaient un niveau de scolarisation moyen à élevé. Toutes les patientes ont bénéficié d'une consultation de génétique médicale au cours de laquelle il leur a été donné des informations sur la technique, son intérêt et ses limites. Il s'agit de femmes enceintes qui avaient soit un âge maternel élevé ou des signes d'appel échographiques et/ ou biochimiques. Une des patientes était porteuse d'une translocation robertsonienne t(14;21) équilibrée. Une amniocentèse a été réalisée chez toutes les gestantes et aucun avortement n'a était induit par ce geste invasif. L’âge gestationnel moyen à la première consultation était de 14 semaines d'aménorrhée (SA) et à l'amniocentèse était de 16 SA et 5 jours. L'analyse FISH a été réalisée, après consentement des couples, sur des cellules non cultivées à partir des échantillons de liquides amniotiques, en utilisant des sondes spécifiques du chromosome 21. Résultats Parmi les 23 patientes qui ont bénéficiées d'un diagnostic anténatal de la trisomie 21 par la technique FISH, nous avons pu rassurer 21 d'entre elles, et nous avons détecté deux cas de trisomie 21 fœtal. Conclusion La technique FISH permet un diagnostic anténatal rapide, en moins de 48h, de la trisomie 21 sur

  20. Une approche décentralisée et adaptative de la gestion d'informations en vision ; application à l'interprétation d'images de cellules en mouvement

    OpenAIRE

    Boucher, Alain

    1999-01-01

    Cette thèse propose une nouvelle approche de la vision par ordinateur, insistant sur le rôle joué par les différentes informations et connaissances présentes dans un système intégré de vision. Ces connaissances peuvent être vues comme un but à atteindre dans la chaine de traitement ou comme un instrument pour guider ces différents traitement. Ce double rôle est mis en évidence en insistant sur la gestion des informations disponibles à tout moment pour effectuer la tâche de reconnaissance. Une...

  1. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  2. La libération par Tupperware ?

    OpenAIRE

    Achin, Catherine; Naudier, Delphine

    2009-01-01

    Au cours des années 1970, le développement de la vente directe à domicile a donné lieu à la formation de cercles de sociabilité entre femmes dans le cadre des réunions Tupperware. Ces rencontres ont contribué à diffuser par capillarité nombre d’idées et pratiques féministes. Elles n’ont pas été sans incidence sur le déroulement de certaines trajectoires de femmes des classes moyennes et populaires. Le partage d’expériences de la soumission féminine, conjugale, et la confrontation aux modèles ...

  3. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  4. Le succès par l’image ?

    OpenAIRE

    Chermette, Myriam

    2008-01-01

    Fig. 1. Paris-Soir, 3 septembre 1933, n°3620, page 1 (détail), coll. ACRPP. L’image fait-elle vendre ? La question n’est pas neuve, a été maintes fois posée et la réponse par l’affirmative paraît aujourd’hui évidente si l’on s’en tient au flux d’images que nous avons quotidiennement sous les yeux. Le monde de la presse, particulièrement, lui accorde une légitimité incontestée, les nouvelles formules laissant davantage de place à l’iconographie. Cettesituation n’est pas le résultat d’un long c...

  5. Etude d’un plasma produit par ablation laser.

    OpenAIRE

    DJAOUANI, Nedjwa

    2014-01-01

    L’ablation laser est une technique d’enlèvement de matière de la surface d’un solide ou d’un liquide par l’irradiation laser, largement utilisée aujourd’hui. Elle s’est développée depuis l’époque de l’invention des lasers (1960). Très rapidement, le processus d’ablation laser est devenu le sujet d’intérêt de beaucoup de scientifiques. Même si la réalisation d’ablation laser est assez simple, ce phénomène est très complexe ce qui confirme le fait que 50 ans après sa découverte i...

  6. Simulation numérique du soudage par frottement malaxage

    OpenAIRE

    Guerdoux, Simon

    2007-01-01

    Ce travail présente le développement d'un outil numérique. Une formulation arbitrairement lagrangienne-eulérienne (ALE) est implémentée dans le logiciel 3D éléments finis FORGE3® pour simuler les différentes étapes du procédé de soudage par frottement malaxage (FSW). Une méthode découplée est utilisée : a) les champs de vitesses, pressions et températures du matériau sont calculés, b) la vitesse de maillage est calculée à partir de l'évolution des frontières du domaine et d'un critère de raff...

  7. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  8. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. PMID:26310455

  9. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  10. Ultra-sonografia intra-oral e transcutânea cervical no diagnóstico diferencial de celulite e abscessos periamigdalianos Intraoral and transcutaneous cervical ultrasound in the differential diagnosis of peritonsillar cellulitis and abscesses

    Directory of Open Access Journals (Sweden)

    Bernardo Cunha Araujo Filho

    2006-06-01

    Full Text Available OBJETIVOS: O objetivo deste estudo é determinar a especificidade, sensibilidade e a acurácia da ultra-sonografia (USG intra-oral e transcutânea no diagnóstico de celulite e abscesso periamigdalianos. FORMA DE ESTUDO: Clínico Prospectivo. MATERIAL E MÉTODO: Trinta e nove pacientes foram atendidos no pronto-socorro de otorrinolaringologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo com diagnóstico clínico de celulite ou abscesso periamigdaliano. Em todos os pacientes, após a avaliação inicial, foram realizadas ultra-sonografias intra-oral e transcutânea. RESULTADOS: O USG intra-oral foi realizado em 35 casos e demonstrou sensibilidade de 95,2%, especificidade de 78,5% e a acurácia de 86,9%. A USG transcutânea foi factível em todos os 39 pacientes e diagnosticou abscesso periamigdaliano em 53,8% dos pacientes. A sensibilidade foi de 80%, a especificidade de 92,8% e a acurácia de 84,5%. CONCLUSÕES: O USG intra-oral foi bastante sensível no diagnóstico de abscessos periamigdalianos. O USG transcutâneo obteve especificidade superior ao intra-oral. Porém, quando o USG transcutâneo foi realizado em pacientes com trismo, este diagnosticou todos os abscessos periamigdalianos, já que se tratava de coleções grandes, comuns em pacientes com trismo. Estes exames tiveram acurácia semelhantes.AIMS: The objective of the present study was to determine the specificity, sensitivity and accuracy of intraoral and transcutaneous ultrasound (US in the diagnosis of peritonsillar cellulitis and abscess. STUDY DESIGN: Clinical-Prospective. MATERIAL AND METHODS: Thirty nine patients were seen at the otorhinolaryngology emergency department of the University Hospital, of the School of Medicine, University of São Paulo, with a clinical diagnosis of peritonsillar cellulitis or abscess. After initial evaluation, all patients were submitted to intraoral and transcutaneous US. RESULTS: Intraoral US was performed on

  11. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability

    Science.gov (United States)

    Kimura, Tetsuya; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-01-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare. PMID:27340539

  12. Estimating photosynthetically active radiation (PAR) at the Earth's surface from satellite observations

    International Nuclear Information System (INIS)

    Current satellite algorithms to estimate photosynthetically active radiation (PAR) at the Earth's surface are reviewed, and selected results are presented. PAR can be obtained directly from top-of-atmosphere solar radiance, which is used to determine the transmissivity of the atmosphere. Since clouds do not absorb significantly at PAR wavelengths, the radiative transfer modeling is generally simplified compared to that for total insolation. The accuracies reported, about 10% and 6% on daily and monthly time scales, respectively, are useful for modeling oceanic and terrestrial primary productivity. The large short-term variability in the ratio of PAR and insolation, essentially due to clouds, is reduced at those time scales, suggesting that reasonably accurate PAR climatologies may be obtained from available insolation climatologies (satellite or other). (author)

  13. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability.

    Science.gov (United States)

    Kimura, Tetsuya; Sakai, Toshinori; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-06-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare. PMID:27340539

  14. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  15. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  16. Facteurs de risque de mortalité par tuberculose pulmonaire

    Science.gov (United States)

    Janah, Hicham; Souhi, Hicham; Kouismi, Hatim; Mark, Karima; Zahraoui, Rachida; Benamor, Jouda; Soualhi, Mona; Bourkadi, Jamal Eddine

    2014-01-01

    La tuberculose est une maladie infectieuse transmissible provoquée par myco-bacterium tuberculosis (bacille de Koch ou BK). Elle représente, selon les estimations del'Organisation Mondiale de la Santé (OMS), l'une des pathologies infectieuses causant le plus de décès au niveau mondial avec plus de 1 million de décès par an. Pour déterminer les facteurs de risque de mortalité au cours de la tuberculose pulmonaire à microscopie positive nous avons mené une étude rétrospective portant sur tous les cas de tuberculose pulmonaire à microscopie positive et qui étaient décédés au cours de leur hospitalisation. Cette étude a colligé 1803 cas de tuberculose sur une période de 2 ans et demi dont 46 sont décédés. La prévalence de décès est de 2,55%. La population se répartit en 32 hommes et 14 femmes. L’âge moyen était de 53ans ± 17 ans. Le tabagisme était retrouvé chez la moitié des cas. Une comorbidité était retrouvée dans 43%, avec 17% de diabète. Le délai de diagnostic avait une médiane de 60 jours avec percentile (30j; 105j). La symptomatologie clinique était dominée par la toux, la dyspnée et les expectorations soit respectivement: 97,8%, 69,6% et 67,4% des cas. Sur le plan radiologique les lésions étaient diffuses et bilatérales dans 76,1% des cas. Tous les patients étaient mis sous SRHZ. 11% avaient présenté une toxicité aux antibacillaires (de type hépatiques dans 3 cas et neurologiques dans 2 cas). Le délai médian de décès était de 8,5 jours (5j; 17j). Les causes de décès retrouvées étaient: Une hépatite fulminante (3 cas), une décompensation acido-cétosique (3 cas), un SDRA (2 cas), des hémoptysies foudroyantes (2 cas), et respectivement un cas secondaire à une décompensation de BPCO, une décompensation cardiaque, une hypoglycémie et un tableau d'anasarque. Cette étude suggère que le terrain, le retard diagnostique et les effets secondaires du traitement sont les principaux facteurs de risque de

  17. The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein.

    Science.gov (United States)

    Wu, Jui-Ching; Espiritu, Eugenel B; Rose, Lesilee S

    2016-04-15

    PAR proteins play important roles in establishing cytoplasmic polarity as well as regulating spindle positioning during asymmetric division. However, the molecular mechanisms by which the PAR proteins generate asymmetry in different cell types are still being elucidated. Previous studies in Caenorhabditis elegans revealed that PAR-3 and PAR-1 regulate the asymmetric localization of LET-99, which in turn controls spindle positioning by affecting the distribution of the conserved force generating complex. In wild-type embryos, LET-99 is localized in a lateral cortical band pattern, via inhibition at the anterior by PAR-3 and at the posterior by PAR-1. In this report, we show that the 14-3-3 protein PAR-5 is also required for cortical LET-99 asymmetry. PAR-5 associated with LET-99 in pull-down assays, and two PAR-5 binding sites were identified in LET-99 using the yeast two-hybrid assay. Mutation of these sites abolished binding in yeast and altered LET-99 localization in vivo: LET-99 was present at the highest levels at the posterior pole of the embryo instead of a band in par-5 embryos. Together the results indicate that PAR-5 acts in a mechanism with PAR-1 to regulate LET-99 cortical localization. PMID:26921457

  18. La limitation de l’ontologie par la logique

    Directory of Open Access Journals (Sweden)

    John J. Drummond

    2009-02-01

    Full Text Available Cet article maintient que l’intérêt de Husserl pour le développement d’une logique pure en tant que théorie de la science limite sa conception de l’ontologie. L’ontologie formelle est, pour Husserl, une théorie formelle des objets de connaissance, dont les catégories fondamentales sont celles de substance, propriété et relation. En outre, les ontologies régionales évoluent au sein des limites catégorielles définies par l’ontologie formelle. Mais une telle ontologie laisse de côté les activités et les processus de tout genre, parmi lesquels le plus important est celui de l’ « avoir à l’esprit ». La phénoménologie transcendantale, en revanche, s’occupe de l’être-conscient-du-monde, un être-conscient qui est cependant inséparable de l’être-dans-le-monde. Cette phénoménologie se situe sur le même terrain ontologique que l’ontologie fondamentale de Heidegger. Mais alors, bien que la notion husserlienne d’ontologie soit limitée par le rôle dominant attribué à la logique en tant que théorie de la science et à la connaissance vraie qui lui est propre, il y a plus d’ontologie chez Husserl que dans son « ontologie ».This paper argues that Husserl’s concern with the development of pure logic as a theory of science limits his conception of ontology. Formal ontology is, for Husserl, a formal theory of the objects of cognition, and its fundamental categories are substantiality, property, and relation. Moreover, regional ontologies work within the categorial boundaries defined by formal ontology. Lost from view in this ontology are activities and processes of various kinds, of which “minding” is the most significant. Husserl’s transcendental phenomenology is an account of being-conscious-of-the-world, a being-conscious, however, that is inseparable from being-in-a-world.  This phenomenology is aimed at the same ontological terrain as Heidegger’s fundamental ontology. Hence, while

  19. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  20. CERCLA interim action at the Par Pond unit: A case study

    International Nuclear Information System (INIS)

    The Par Pond unit designated under CERCLA consists of sediments within a Savannah River Site (SRS) cooling water reservoir. The sediments are contaminated with radionuclides and nonradioactive constituents from nuclear production reactor operations. The mercury in Par Pond is believed to have originated from the Savannah River. Because of Par Pond Dam safety Issues, the water level of the reservoir was drawn down, exposing more than 1300 acres of contaminated sediments and triggering the need for CERCLA interim remedial action. This paper presents the interim action approach taken with Par Pond as a case study. The approach considered the complexity of the Par Pond ecosystem, the large size of Par Pond, the volume of contaminated sediments, and the institutional controls existing at SRS. The Environmental Protection Agency (EPA) considers units with large volumes of low-concentration wastes, as is the case with Par Pond, to be open-quotes special sites.close quotes Accordingly, EPA guidance establishes that the range of alternatives developed focus primarily on containment options and other remedial approaches that mitigate potential risks associated with the open-quotes special site.close quotes The remedial alternatives, according to EPA, are not to be prohibitively expensive or difficult to implement. This case study also is representative of the types of issues that will need to be addressed within the Department of Energy (DOE) complex as nuclear facilities are transitioned to inactive status and corrective/remedial actions are warranted

  1. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation

    Science.gov (United States)

    Jha, Hem C.; Sun, Zhiguo; Upadhyay, Santosh K.; El-Naccache, Darine W.; Singh, Rajnish K.; Sahu, Sushil K.; Robertson, Erle S.

    2016-01-01

    Studies have suggested that Epithelial–Mesenchymal Transition (EMT) and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein) is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA) encoded by Kaposi's Sarcoma associated herpesvirus (KSHV) regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition) during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies. In this study, we demonstrate that Par3 is significantly up-regulated in KSHV-infected primary B-cells. Further, Par3 interacted with LANA in KSHV positive and LANA expressing cells which led to translocation of Par3 from the cell periphery to a predominantly nuclear signal. Par3 knockdown led to reduced cell proliferation and increased apoptotic induction. Levels of SNAIL was elevated, and E-cadherin was reduced in the presence of LANA or Par3. Interestingly, KSHV infection in primary B-cells led to enhancement of SNAIL and down-regulation of E-cadherin in a temporal manner. Importantly, knockdown of SNAIL, a major EMT regulator, in KSHV cells resulted in reduced expression of LANA, Par3, and enhanced E-cadherin. Also, SNAIL bound to the promoter region of p21 and can regulate its activity. Further a SNAIL inhibitor diminished NF-kB signaling through upregulation of Caspase3 in KSHV positive cells in vitro. This was also supported by upregulation of SNAIL and Par3 in BC-3 transplanted NOD-SCID mice which has potential as a therapeutic target for KSHV-associated B-cell lymphomas. PMID:27463802

  2. Identification of uPAR-positive chemoresistant cells in small cell lung cancer.

    Directory of Open Access Journals (Sweden)

    Margarita Gutova

    Full Text Available BACKGROUND: The urokinase plasminogen activator (uPA and its receptor (uPAR/CD87 are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR system has been of great interest in cancer research because it is involved in the development of most invasive cancer phenotypes and is a strong predictor of poor patient survival. However, little is known about the role of uPA/uPAR in small cell lung cancer (SCLC, the most aggressive type of lung cancer. We therefore determined whether uPA and uPAR are involved in generation of drug resistant SCLC cell phenotype. METHODS AND FINDINGS: We screened six human SCLC cell lines for surface markers for putative stem and cancer cells. We used fluorescence-activated cell sorting (FACS, fluorescence microscopy and clonogenic assays to demonstrate uPAR expression in a subpopulation of cells derived from primary and metastatic SCLC cell lines. Cytotoxic assays were used to determine the sensitivity of uPAR-positive and uPAR-negative cells to chemotherapeutic agents. The uPAR-positive cells in all SCLC lines demonstrated multi-drug resistance, high clonogenic activity and co-expression of CD44 and MDR1, putative cancer stem cell markers. CONCLUSIONS: These data suggest that uPAR-positive cells may define a functionally important population of cancer cells in SCLC, which are resistant to traditional chemotherapies, and could serve as critical targets for more effective therapeutic interventions in SCLC.

  3. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  4. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Liliana Semenas

    1999-08-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  5. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  6. Phacoemulsification and pars plana vitrectomy: A combined procedure

    Directory of Open Access Journals (Sweden)

    Jain Vandana

    2007-01-01

    Full Text Available Aim: To describe the results of a combined procedure including phacoemulsification, insertion of posterior chamber intraocular lens (PCIOL and pars plana vitrectomy (PPV in eyes with vitreoretinal pathology and coexisting significant cataract. Design: Retrospective, consecutive, noncomparative, interventional case series. Materials and Methods: Medical records of patients who had undergone phacoemulsification, PPV and PCIOL implantation as a combined procedure between January 2000 and December 2004 were retrospectively reviewed. The main outcome measures were the anatomical success of retina, defined as reattached retina, intraoperative and postoperative complications and functional success in terms of final best corrected visual acuity. Results: In all, 65 eyes of 64 patients were included. The mean age of the patients was 50.9 years ± 17.1 (range, five to 82 years. Vitreous hemorrhage with or without retinal detachment (19 eyes, 29.2% was the most common indication for the vitreoretinal procedure. Primary anatomical success of retina was achieved in 59 eyes (90.7%. Visual acuity improved in 48 eyes (73.8%, was unchanged in 12 eyes (18.5% and deteriorated in five eyes (7.7%. Postoperative inflammation was significantly more in the subgroup of previously vitrectomized eyes (42% ( P =0.014, Fisher exact test compared to those which underwent primary vitrectomy. Conclusions: Combined surgery is a feasible option for patients with vitreoretinal diseases and cataract.

  7. Los parásitos de los animales domésticos.

    OpenAIRE

    Cruz B. Luis

    2012-01-01

    Desde el año 1937, el Departamento Nacional de Agricultura, desean prestar un servicio más efectivo para el agricultor costarricense, viene publicando en su Revista Agrícola, artículos referentes a los parásitos que infestan nuestro ganados e incluyendo siempre las medidas más prácticas para su control. Durante muchos años, los parásitos de los animales han constituido un verdadero flagelo para la industria costarricense, entorpeciendo su progreso; pero desde que el Servicio de Par...

  8. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  9. Recruitment of the ParG Segregation Protein to Different Affinity DNA Sites▿ §

    OpenAIRE

    Zampini, Massimiliano; Derome, Andrew; Bailey, Simon E. S.; Barillà, Daniela; Hayes, Finbarr

    2009-01-01

    The segrosome is the nucleoprotein complex that mediates accurate plasmid segregation. In addition to its multifunctional role in segrosome assembly, the ParG protein of multiresistance plasmid TP228 is a transcriptional repressor of the parFG partition genes. ParG is a homodimeric DNA binding protein, with C-terminal regions that interlock into a ribbon-helix-helix fold. Antiparallel β-strands in this fold are presumed to insert into the OF operator major groove to exert transcriptional cont...

  10. Sécurité et immigration : vers une gouvernementalité par linquiétude ?

    OpenAIRE

    Bigo, Didier

    2006-01-01

    L'immigration est lue à travers le prisme de la sécurité par certains hommes politiques, par les polices et certains services sociaux, par nombre de journalistes et une fraction de l'opinion publique. Malgré les critiques fréquentes et argumentées d'une telle perception, malgré l'existence de discours alternatifs, cette lecture continue, très largement, d'être dominante. Pourquoi ? Qu'est ce qui pousse tous ces acteurs à faire un lien entre crime, chômage, terrorisme, fanatisme et migration ?...

  11. Platelet–leukocyte aggregation induced by PAR agonists: regulation by nitric oxide and matrix metalloproteinases

    OpenAIRE

    Chung, Ada W Y; Radomski, Anna; Alonso-Escolano, David; Jurasz, Paul; Stewart, Michael W; Malinski, Tadeusz; Radomski, Marek W

    2004-01-01

    Platelet–leukocyte aggregation (PLA) links haemostasis to inflammation. The role of nitric oxide (NO) and matrix metalloproteinases (MMP-1, -2, -3, -9) in PLA regulation was studied.Homologous human platelet–leukocyte suspensions were stimulated with thrombin (0.1–3 nM) and other proteinase activated receptor-activating peptides (PAR-AP), including PAR1AP (0.5–10 μM), PAR4AP (10–70 μM), and thrombin receptor-activating peptide (1–35 μM).PLA was studied using light aggregometry with simultaneo...

  12. Recuit thermique rapide de semi-conducteur par énergie micro-onde

    OpenAIRE

    Covas, M.; Gay, H.

    1993-01-01

    Nous proposons une méthode de recuit thermique rapide du silicium par énergie micro-onde. Cette technique offre les mêmes avantages que les traitements thermiques rapides par lumière incohérente, c'est-à-dire des durées de chauffage très brèves, limitant ainsi la diffusion des dopants, et un traitement plaquette par plaquette : les risques de contamination de tout un lot sont ainsi éliminés. De plus notre méthode requiert une faible énergie : pour parvenir à des recuits de qualité similaire à...

  13. Downregulation of uPAR and Cathepsin B Retards Cofilin Dephosphorylation

    OpenAIRE

    Christopher S Gondi; Kandhukuri, Neelima; Kondraganti, Shakuntala; Gujrati, Meena; Olivero, William C.; Dinh, Dzung H.; Rao, Jasti S.

    2006-01-01

    Cathepsin B and uPAR play key roles in cancer cell migration and invasion. Here, we demonstrate that the simultaneous, siRNA-mediated downregulation of uPAR and cathepsin B inhibits glioma cell migration and is accompanied by cytoskeletal condensation. We show that the dephosphorylation of cofilin is inhibited by the downregulation of uPAR alone and, to a lesser extent, by the downregulation of cathepsin B alone, and that the effect was much higher by the downregulation of both molecules by p...

  14. In vitro modulation of radiation-induced FAS-related apoptosis in CD34{sup +} progenitor cells by combination cytokines; Reduction de l'apoptose radio-induite impliquant le recepteur FAS au niveau des cellules hematopoietiques CD34{sup +} par une combinaison de cytokines

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Soutif, A.; Herodin, F

    1998-07-01

    Combination cytokines such as SCF, Flt-3 ligand, IL-3 and thrombopoietin can modulate Fas mRNA expression by in vitro irradiated CD34{sup +} cells which results in a moderate decrease of apoptotic ratio and an improved rate of clonogenicity of the irradiated progenitors. (authors)

  15. L’hypertension artérielle et les désordres vasculaires induits par l'érythropoïétine recombinante humaine et le système rénine-angiotensine-aldostérone : Effet de l’exercice et des cellules T régulatrices

    OpenAIRE

    Barhoumi, Tlili,

    2011-01-01

    Hypertension (HTN) is one of the most frequent disease and is of greatest concern in Western countries.HTN is often associated with overweight, kidney, heart and endocrine system disease. Vasculardisorders, associated with HTN induced by erythropoietin (r-HuEPO) treatment in chronic kidneydisease or in case of disruption of the renin-angiotensin-aldosterone system (RAAS), associated increasein arterial stiffness, endothelial dysfunction, unbalanced endothelin-1/nitric oxide ratio (ET-1/NO) an...

  16. Himert: industrial calibration of type S, B and C thermocouples by comparison to metal - carbon eutectic cells: interest and perspectives; Etalonnage industriel de couples thermoelectriques type S, B et C par comparaison a des cellules eutectiques metal - carbone: interet et perspective

    Energy Technology Data Exchange (ETDEWEB)

    Fourrez, S.; Bailleul, G. [Thermocoax SASn 61 - Flers (France); Morice, R. [Laboratoire National de Metrologie et d' Essais (LNE), 75 - Paris (France); Machin, G. [National Physical Lab., Teddington (United Kingdom)

    2003-07-01

    For a long time temperature calibration laboratories have calibrated temperature sensors (resistance thermometers and thermocouples) by comparison to fixed point cells (between 0 deg C to 961.78 deg C) or by comparison to standard sensors in an homogenous and stable environment. For the calibration by comparison to fixed point cells uncertainties are small enough and almost satisfy industrials needs. Uncertainties become more important for calibration by comparison at high temperature (> 1000 deg C). Due to the standard calibration uncertainties it is very difficult for calibration laboratories to guaranty class 1 for the type R and S thermocouples up to 1600 deg C. Moreover calibration of type C thermocouples (Tungsten-Rhenium) up to 2000 deg C can not be performed by industrial laboratories. Metal-Carbon eutectic cells which will be developed during the HIMERT project, will help to reduce these uncertainties and at the same time will offer primary and industrial laboratories new calibration facilities. In addition Metal-Carbon eutectic cells can also be made into blackbody sources. These can be used to greatly improve traceability to industry and help difficult industrials measurement problems such as process control while viewing through continually contaminating windows. (authors)

  17. Air breath control radiotherapy in severe insufficiency respiratory patients with N.S.C.L.: application for deformable registration method in thoracic radiotherapy; Radiotherapie avec blocage respiratoire pour les grands insuffisants respiratoires atteints d'un carcinome pulmonaire non a petites cellules (Protocole RESPI 2000): application a la modelisation des deformations d'organes par recalage deformable

    Energy Technology Data Exchange (ETDEWEB)

    Sarrut, D.; Pommier, P.; Carrie, C. [Centre Leon-Berard, Dept. de Radiotherapie, CREATIS, Unite CNRS 5515, Inserm 630, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, Dept. de Biostatistique, 69 - Lyon (France)

    2006-11-15

    Purpose. Using deformable registration methods from a phase two clinical study of air breath control during radiotherapy in patients suffering from severe respiratory insufficiency and non-small cell lung carcinoma. Patients and methods, Between April 2002 and November 2005, 22 patients with severe respiratory insufficiency were treated with curative intent by conformal therapy combined with active breathing control. Results. After a mean of follow-up of 22 months, the local control rate is 28% and the method is feasible despite the severe respiratory insufficiency. However the overall survival is still poor due to metastatic widespread. For the second part of the study, the clinical protocol was also used for two studies using deformable registration methods. In the first study, a deformable registration method has been developed in order to register several breath-hold 3D CT of the same patient acquired at several days of interval. It allowed quantifying the inter-fraction breath-hold reproducibility by analysing the resulting displacement field. For 6 patients, the breath-hold was effective, while for 2 patients, motion greater than 10 mm were detected. The second study aimed to simulate 4D images from 3D breath-hold images. Developing an ad-hoc methodology based on the interpolation of 3D dense deformation fields performed it. The approach has been validated with expert selected landmarks, with accuracy lower than 3 mm. Conclusion. ABC is feasible, even in case of severe insufficiency respiratory syndrome but metastatic widespread disease is still a major challenge even with an acceptable local control rate without serious side effects: regarding the deformable registration method. Such artificial 4D images could allow decreasing the dose need to acquire a full 4D image, to simulate irregular breathing pattern and to be used for 4D dosimetry planning. (author)

  18. Synthesis of nano-particles by soft chemistry: structural, morphological and dimensional control. Studies of the electrochemical properties (towards dyes solar cells); Synthese de nanoparticules par chimie douce: controle structural, morphologique et dimensionnel. Etudes des proprietes electrochimiques (vers les cellules solaires a colorants)

    Energy Technology Data Exchange (ETDEWEB)

    Cassaignon, S.; Koelsch, M.; Jolivet, J.P. [Paris-6 Univ. Pierre et Marie Curie, Chimie de la Matiere Condensee de Paris, CNRS UMR 7574, 75 - Paris (France)

    2006-07-01

    In this work are described the electrochemical behaviour of different TiO{sub 2} films (anatase, brookite and rutile) in aqueous solution and the influence of the parameters as the crystal structure and the morphology on the electrochemical answer. To complete this study, the capacity of the double layer has been measured by impedance spectroscopy. Voltage measurements of TiO{sub 2} sensitized by a dye will allow to discuss the reversibility of the system and the rearrangement mechanisms. At last, the influence of the nature of the TiO{sub 2} particles (anatase, rutile and brookite) on the photovoltage has been studied in order to estimate their interest for photovoltaic devices. (O.M.)

  19. Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2.

    OpenAIRE

    Easter, C L; Sobecky, P A; Helinski, D. R.

    1997-01-01

    A 3.2-kb region of the broad-host-range plasmid RK2 has been shown to encode a highly efficient plasmid maintenance system that functions in a vector-independent manner. This region, designated par, consists of two divergently arranged operons: parCBA and parDE. The 0.7-kb parDE operon promotes plasmid stability by a postsegregational killing mechanism that ensures that plasmid-free daughter cells do not survive after cell division. The 2.3-kb parCBA operon encodes a site-specific resolvase p...

  20. Average of peak-to-average ratio (PAR) of IS95 and CDMA2000 systems-single carrier

    OpenAIRE

    Lau, VKN

    2001-01-01

    Peak-to-average ratio (PAR) of a signal is an important parameter. It determines the input backoff factor of the amplifier to avoid clipping and spectral regrowth. We analyze and compose the PAR of the downlink signal for IS95 and the CDMA2000 single-carrier systems. It is found that the PAR of the transmitted signal depends on the Walsh code assignment. Furthermore, we found that the PAR of CDMA2000 signal is always lower than the IS95 signal. Finally, PAR control by Walsh code selection is ...

  1. Modélisation 3D d'objets par un capteur visuel déplacé par un opérateur

    OpenAIRE

    Coudrin, Benjamin; Devy, Michel; Brethes, Ludovic; ORTEU, Jean-José

    2009-01-01

    Nous évoquons dans cet article, la problématique de la modélisation 3D d'un objet par un capteur visuel déplacé manuellement par un opérateur. L'objet est posé sur un plan : l'opérateur déplace le capteur sur une demi-sphère centrée sur l'objet. Plusieurs fonctions doivent être développées pour construire un modèle par ce procédé : acquisitions 2D et 3D, estimation des déplacements du capteur à partir des points suivis dans la séquence d'images 2D et recalage des données 3D acquises en chaque...

  2. Modélisation 3D d'objets par un capteur visuel déplacé par un opérateur

    OpenAIRE

    Coudrin, Benjamin; Devy, Michel; Brethes, Ludovic; Orteu, Jean-José

    2009-01-01

    National audience Nous évoquons dans cet article, la problématique de la modélisation 3D d'un objet par un capteur visuel déplacé manuellement par un opérateur. L'objet est posé sur un plan : l'opérateur déplace le capteur sur une demi-sphère centrée sur l'objet. Plusieurs fonctions doivent être développées pour construire un modèle par ce procédé : acquisitions 2D et 3D, estimation des déplacements du capteur à partir des points suivis dans la séquence d'images 2D et recalage des données ...

  3. Modélisation hydrodynamique du schéma d'allumage par choc pour la fusion par confinement inertiel

    OpenAIRE

    Vallet, Alexandra

    2014-01-01

    Le schéma d'allumage par choc pour la fusion par confinement inertiel utilise une impulsion laser intense à la fin d'une phase d'assemblage de combustible. Les paramètres clefs de ce schéma sont la génération d'une haute pression d'ablation, l'amplification de la pression du choc généré par un facteur supérieur à cent et le couplage du choc avec le point chaud de la cible. Dans cette thèse, de nouveaux modèles semi-analytiques sont développés afin de décrire le choc d'allumage depuis sa génér...

  4. L'apport des professionnels IST d'une cellule de veille dans l'appui à la stratégie et à l'animation scientifique et technique: retours d'expériences

    OpenAIRE

    Giovannini, F; De Mareschal, S.

    2010-01-01

    / Présentation réalisée lors d'une journée organisée par l'association des documentalistes du CNRS Go!doc. Les objectifs étaient de présenter la démarche de veille au Cemagref, son dispositif, son cadre (la DPV) ainsi que des exemples de réalisations en national et en local.

  5. A clinical study on the therapeutic effect of rituximab in combination with autologous peripheral blood stem cell transplantation in treatment of CD20+ B cellulous non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Yong-sheng CHEN

    2013-07-01

    Full Text Available Objective To investigate the therapeutic effect of autologous peripheral blood stem cell transplantation (APBSCT in combination with rituximab in treatment of CD20+ B cellulous non-Hodgkin's lymphoma (B-NHL. Methods Sixty patients with CD20+ aggressive or refractory and recurrent B-NHL and treated with APBSCT in our department from Jan. 2005 to Jan. 2011 were admitted. All the subjects were divided into 2 groups according to their own choice: 25 patients received rituximab treatment (treatment group and 35 patients were treated without rituximab treatment (control group. All patients underwent chemotherapy and APBSCT. For patients in treatment group, rituximab was used with CHOP before collecting the stem cells and after the transplantation. After transplantation, rituximab and IL-2 were used in treatment group every 3-6 months as maintenance treatment. Results No side effect was observed during the use of rituximab either before or after transplantation. The mononuclear cell count in treatment and control group was (8.2±2.9×108/kg and (8.4±3.9×108/kg (P=0.822, respectively; CD34+cell count was (12.3±12.7×106/kg and (13.2±13.9×106/kg (P=0.799, respectively. Haemopoiesis reconstruction was successfully achieved in the patients of treatment group, while 3 patients in control group failed to have haemopoiesis reconstruction. No significant difference was found between two groups on the recovery time of neutrophilic granulocytes and platelets. All patients achieved complete remission. The average follow-up time was 22 months. The disease relapsed in two patients in treatment group and six in control group. The 3-year overall survival rate in treatment group (91.6% was a little higher than that in control group (69.5%, P=0.060. Conclusion To patients of CD20+ B lymphoma, the use of rituximab shows no side effect before or after collection of stem cell and hemopoiesis reconstruction, and the overall survival rate may be improved.

  6. Controle social em saúde: o caso do Pará Social control in health: Pará's case

    OpenAIRE

    Solange Conceição Albuquerque de Cristo

    2012-01-01

    Este artigo objetiva contribuir para um exame mais circunstanciado das experiências de controle social. De acordo com o Cadastro dos Conselhos Municipais de Saúde no Brasil (2006), quase um terço da presidência dos Conselhos de Saúde no Pará é ocupada por representantes do segmento dos usuários. As análises desenvolvidas, a partir de entrevistas realizadas com presidentes de dois conselhos no Pará, permitiram compreender os desafios que os Conselhos de Saúde vêm enfrentando para participar da...

  7. Bacterial Mitosis: ParM of Plasmid R1 Moves Plasmid DNA by an Actin-like Insertional Polymerization Mechanism

    DEFF Research Database (Denmark)

    Møller-Jensen, Jakob; Borch, Jonas; Dam, Mette;

    2003-01-01

    Bacterial DNA segregation takes place in an active and ordered fashion. In the case of Escherichia coli plasmid R1, the partitioning system (par) separates paired plasmid copies and moves them to opposite cell poles. Here we address the mechanism by which the three components of the R1 par system...... act together to generate the force required for plasmid movement during segregation. ParR protein binds cooperatively to the centromeric parC DNA region, thereby forming a complex that interacts with the filament-forming actin-like ParM protein in an ATP-dependent manner, suggesting that plasmid...... movement is powered by insertional polymerization of ParM. Consistently, we find that segregating plasmids are positioned at the ends of extending ParM filaments. Thus, the process of R1 plasmid segregation in E. coli appears to be mechanistically analogous to the actin-based motility operating...

  8. Inmunidad frente a infecciones: bacterias, virus, hongos y parásitos

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco de la Calle, Francisco Manuel; Vázquez Araujo, Begoña

    2012-01-01

    Respuesta inmune frente a la infección: Bacterias extracelulares, bacterias intracelulares, hongos, virus, parásitos. Inmunidad innata, inmunidad adaptativa, mecanismos de evasión, consecuencias perjudiciales de la respuesta inmune.

  9. Etude de pièces anciennes par analyse PIXE. Comparaison avec d'autres techniques

    OpenAIRE

    Frontier, J.P.; Brissaud, I.; Gruel, K.; Rousset, M; Tarrats-Saugnac, A.

    1988-01-01

    Des pièces de monnaie anciennes de trois espèces différentes (gauloises, romaines, hammadites) ont été analysées par émission de rayons X induite par particules chargées (PIXE). Des études par microsonde électronique et activation par neutrons lents et rapides ont permis une comparaison des diverses techniques pour préciser les informations et compléter les résultats expérimentaux. Dans cet article nous présentons les conclusions d'intérêt archéologique qui peuvent être extraites de ces diffé...

  10. ANALYSES EXPERIMENTALES ET NUMERIQUES DU PROCEDE DE SOUDAGE PAR FRICTION MALAXAGE FSW

    OpenAIRE

    Lorrain, Olivier

    2010-01-01

    Le soudage par friction malaxage FSW est un procédé de soudage à l'état solide, sans fusion du matériau. La soudure est réalisée par l'action d'un outil composé d'un épaulement et d'un pion positionné à l'interface des deux pièces à souder. L'outil a deux rôles : échauffement de la matière par frottement de l'épaulement, malaxage de la matière par l'intermédiaire du pion. Ce travail de thèse s'inscrit dans le cadre d'un partenariat entre Arts et Métiers ParisTech et l'Institut de Soudure. Son...

  11. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter;

    2015-01-01

    during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative or......The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated by...

  12. PAR-Aware Large-Scale Multi-User MIMO-OFDM Downlink

    CERN Document Server

    Studer, Christoph

    2012-01-01

    We investigate an orthogonal frequency-division multiplexing (OFDM)-based downlink transmission scheme for large-scale multi-user (MU) multiple-input multiple-output (MIMO) wireless systems. The use of OFDM causes a high peak-to-average (power) ratio (PAR), which necessitates expensive and power-inefficient radio-frequency (RF) components at the base station. In this paper, we present a novel downlink transmission scheme, which exploits the massive degrees-of-freedom available in large-scale MU-MIMO-OFDM systems to achieve low PAR. Specifically, we propose to jointly perform MU precoding, OFDM modulation, and PAR reduction by solving a convex optimization problem. We develop a corresponding fast iterative truncation algorithm (FITRA) and show numerical results to demonstrate tremendous PAR-reduction capabilities. The significantly reduced linearity requirements eventually enable the use of low-cost RF components for the large-scale MU-MIMO-OFDM downlink.

  13. Ambroise Paré (1510-1590)--Traek af kirurgfagets historie og dets medi- kamentelle aspekter

    DEFF Research Database (Denmark)

    Norn, Svend; Permin, Henrik; Kruse, Poul R; Kruse, Edith

    2010-01-01

    . Paré abolished the painful practise of cautery to stop bleeding and used ligatures and dressings instead. A multitude of subjects were included in his writings such as military surgery, aneurysm, hernia, obstetrics and plague, and through his techniques he guided the development of the gentle art of...... surgery. Paré became the founder of modern surgery, a restorative process that heals the body with minimal suffering....

  14. Pars Plana Ahmed Implantation Combined with 23-gauge Vitrectomy for Refractory Neovascular Glaucoma in Diabetic Retinopathy

    OpenAIRE

    Jeong, Hoon Seok; Nam, Dong Heun; Paik, Hae Jung; Lee, Dae Yeong

    2012-01-01

    Purpose To evaluate the efficacy and safety of a pars plana Ahmed valve implantation combined with 23-gauge sutureless vitrectomy in the treatment of patients with medically uncontrolled neovascular glaucoma (NVG) in proliferative diabetic retinopathy (PDR). Methods The authors retrospectively reviewed the records of 11 consecutive patients with refractory NVG in PDR who underwent a 23-gauge sutureless vitrectomy combined with pars plana placement of an Ahmed valve implant. Control of intraoc...

  15. Transconjunctival 25-gauge pars plana vitrectomy and internal limiting membrane peeling for chronic macular edema

    OpenAIRE

    Cho M; D'Amico DJ

    2012-01-01

    Minhee Cho, Donald J D'AmicoWeill Cornell Medical College, Department of Ophthalmology, New York, NY, USABackground: The purpose of this study was to investigate the visual and anatomic outcomes in patients with chronic macular edema who underwent 25-gauge pars plana vitrectomy with internal limiting membrane peeling.Methods: This study was a retrospective chart review of 24 eyes from 21 patients who underwent 25-gauge pars plana vitrectomy and indocyanine green-assisted internal limi...

  16. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  17. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  18. Negative Regulation of Neuromedin U mRNA Expression in the Rat Pars Tuberalis by Melatonin

    OpenAIRE

    Sayaka Aizawa; Ichiro Sakata; Mai Nagasaka; Yuriko Higaki; Takafumi Sakai

    2013-01-01

    The pars tuberalis (PT) is part of the anterior pituitary gland surrounding the median eminence as a thin cell layer. The characteristics of PT differ from those of the pars distalis (PD), such as cell composition and gene expression, suggesting that the PT has a unique physiological function compared to the PD. Because the PT highly expresses melatonin receptor type 1, it is considered a mediator of seasonal and/or circadian signals of melatonin. Expression of neuromedin U (NMU) that is know...

  19. Lensectomy using a bimanual microincision cataract surgery technique during pars plana vitrectomy.

    Science.gov (United States)

    Byeon, Suk Ho; Kwon, Oh W

    2009-01-01

    Lens extraction during vitrectomy is sometimes necessary to obtain an adequate view of the retina. Currently, phacoemulsification through a clear corneal incision with implantation of a foldable intraocular lens has become the preferred technique for cataract extraction during pars plana vitrectomy. The authors described the technique of lensectomy using a bimanual microincisional cataract surgery technique during pars plana vitrectomy and insertion of the intraocular lens at the end of surgery, which has several advantages over conventional coaxial phacoemulsification procedures. PMID:19205506

  20. Pars plana vitrectomy for malignant glaucoma in non-glaucomatous and in filtered glaucomatous eyes

    OpenAIRE

    Matlach, Juliane; Slobodda, Joerg; Grehn, Franz; Klink, Thomas

    2013-01-01

    Purpose: To assess the outcomes of pars plana vitrectomy for the treatment of malignant glaucoma in patients with and without previous filtration surgery. Patients and methods: Data of 15 patients developing malignant glaucoma after trabeculectomy (60%) or following ophthalmic interventions other than filtration surgery (40%) were recorded retrospectively. Pars plana vitrectomy was performed in case of failed medical or laser treatment recreating the normal pathway of aqueous humor. The main ...

  1. On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

    OpenAIRE

    Luo, Xin; Kraus, W. Lee

    2012-01-01

    PARP-1 (poly[ADP-ribose] polymerase-1) is a nuclear enzyme that processes varied stress signals and, in response, determines cell fates based on the type and strength of the stress stimulus. PAR (poly[ADP-ribose]) is generated by PARP-1 and regulates many of these stress response pathways. In this review, Kraus and colleagues discuss recent important findings that elucidate the role of PAR and PARP-1 in the regulation of stress response.

  2. 25-Gauge pars plana vitrectomy for ciliary block (malignant) glaucoma.

    Science.gov (United States)

    Meng, Li; Wei, Wenbin; Li, Yanlong; Hui, Xiaoying; Han, Xiaodong; Shi, Xiaobo

    2015-08-01

    To evaluate the efficacy of 25-ga pars plana vitrectomy (PPV) and 25-ga PPV combined with phacoemulsification surgery for managing ciliary block (malignant) glaucoma. The medical records of 11 eyes, in nine consecutive patients with malignant glaucoma were retrospectively reviewed to determine the efficacy of 25-ga PPV for alleviating this disease. All phakic eyes underwent phacoemulsification surgery during vitrectomy. Control of intraocular pressure (IOP), pre- and postoperative best-corrected visual acuity (BCVA), and development of intra- and postoperative complications were evaluated during follow-up. Malignant glaucoma was promptly resolved, and recurrence was not observed during a mean follow-up period of 12.7 ± 3.2 (range 6-18) months. The mean IOP decreased from 35.9 ± 2.9 mmHg, preoperatively, to 16.0 ± 1.4 mmHg, measured at last visit (P = 0.013). Although IOP control was achieved in all eyes after surgery, two eyes required long-term topical antiglaucoma medication. The mean logarithm of the minimum angle of resolution BCVA improved from +0.69 ± 0.11, preoperatively, to +0.29 ± 0.07, postoperatively (P = 0.027). No severe intraoperative complications were observed. Postoperative complications mostly occurred during the first week after surgery, including transient corneal edema and Descemet's membrane folds in three eyes, fibrotic exudation in 2, local iris posterior synechia in 1, and transient hypotony in 1, which were resolved spontaneously or with medication. The 25-ga PPV procedure seems to be safe and effective for treating malignant glaucoma. Combined vitrectomy with phacoemulsification surgery and a staged surgical approach may improve the success rate. PMID:25062710

  3. La relecture du romancero par les vihuelistes de la Renaissance

    Directory of Open Access Journals (Sweden)

    Pascal Martel

    1999-01-01

    Full Text Available Les romances espagnols de la Reconquête relataient sur le mode épique des faits passés sur une mélodie récurrente qui servait surtout d’outil mnémotechnique pour réciter de longues narrations. Lorsque Diego Pisador reprend un romance, il n’en prend que quelques vers : du coup, le rapport entre les mots et les notes se fait plus étroit. D’un poème épique, il élabore une amplification lyrique, une véritable composition musicale, opère un véritable changement d’esthétique : le passage de la longue narration sur un thème musical bref et récurrent qui caractérisait le romance médiéval de la Reconquista, à une forme musico-littéraire plus brève mais plus élaborée, propre à introduire la vibration lyrique dans la matière épique. Familier de la Cour, il entend ainsi servir les desseins politiques de Philippe Il à qui il dédie son œuvre : le compositeur vihueliste qu’était Pisador en effet participe à l’effort de l’intégration du Maure poursuivi par la politique de la Maison d’Autriche. Mais les noces n’eurent pas lieu et les Maures furent au contraire expulsés en 1609. L’analyse de cette chanson nous donne l’occasion de découvrir les moyens employés par le musicien pour se livrer à une véritable amplification lyrique d’un simple récit par la musique. La chanson savante n’est pas non plus une composition dans laquelle la mélodie traduirait simplement en musique le texte poétique de façon tout à fait parallèle : la musique n’est pas qu’une répétition, sous une autre forme, de la parole, ou bien l’image sonore d’un texte. Musique et poésie constituent deux moyens autonomes d’expression mais qui, dans une chanson, concourent à un même but : ces deux moyens d’expression tantôt se rejoignant, tantôt s’émancipant l’un de l’autre, de sorte que le propre de la chanson réside justement dans cette tension constante entre ses deux composantes. La mise en musique

  4. Outcome of early pars plana vitrectomy in exogenous endophthalmitis

    International Nuclear Information System (INIS)

    Objective: To evaluate the role of early pars plana vitrectomy (PPV) in cases of exogenous endophthalmitis in terms of final visual outcome and to determine association between various study variables and final visual outcome. Study Design: Quasi experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi, from Aug 2010 to May 2012. Patients and Methods: Eleven cases of exogenous endophthalmitis (post surgical/post traumatic) were managed surgically through 20 G or 23/25 G complete and early PPV. Vitreous aspirate/explanted intraocular lens (IOL) were sent for culture and sensitivity in all cases. Intra and post operative complications were recorded and best corrected visual acuity (BCVA) at 3 months post operative interval was taken as final visual acuity. Results: Median age of study population was 55 years with male preponderance (64%). Approximately 2/3 rd of study population developed endophthalmitis within 6 weeks of surgery/trauma and 55% of patients were operated within 2 weeks of presentation. Positive culture from vitreous aspirate/IOL explant was obtained in 27% of cases. All the patients had initial BCVA in the range of counting finger (CF) at 2 meter to perception of light (PL+). However, 18% of the patients achieved final BCVA of 6/12 or better and 64% achieved final BCVA of 6/36 or better. Maculopathy (macular scar, macular pucker), corneal decompensation, corneal opacity and raised intraocular pressure were the major complications associated with compromised visual outcome. Conclusion: With the advancement in vitreoretinal surgical techniques and availability of more sophisticated viewing and illumination systems, early and complete vitrectomy for post operative or post traumatic endophthalmitis results in favorable visual outcome and early rehabilitation. (author)

  5. Pars Plana Vitrectomy and Intravitreal Phacoemulsification for Dropped Nuclei

    Directory of Open Access Journals (Sweden)

    Khalil Ghasemi Falavarjani

    2012-01-01

    Full Text Available Purpose: To report the outcomes of pars plana vitrectomy (PPV and intravitreal phacoemulsification in patients with dropped nuclei/nuclear fragments following complicated cataract surgery. Methods: In this retrospective case series, charts of patients who had undergone PPV and intravitreal phacoemulsification for removal of dislocated nuclei/lens fragments were reviewed. After standard PPV, a conventional phacoemulsification probe with an amputated sleeve was used for grasping and emulsifying the nucleus/nuclear fragments in mid/anterior vitreous cavity. Pre- and postoperative visual acuity, and intra- and postoperative complications were recorded. Results: A total of 22 patients with mean age of 71.1΁8.2 years were studied. Mean interval between complicated cataract surgery and PPV was 26.6΁36.5 (range: 0-120 days. Patients were followed for a mean of 105.5΁57.5 days. Preoperatively, best corrected visual acuity was 2.4΁0.6 logMAR which was improved to 1.4΁0.6 logMAR at final follow-up (P<0.001. Intraoperative complications included iatrogenic peripheral retinal breaks in three eyes. Postoperative complications consisted of epiretinal membrane formation in one eye, hypotony in one eye, and medically-controlled glaucoma in 2 eyes. Conclusion: In this series, PPV and intravitreal phacoemulsification using a conventional phacoemulsification probe in patients with dropped nuclei/nuclear fragments following complicated cataract surgery resulted in visual improvement without any complications directly attributable to the probe.

  6. Unitary synaptic connections among substantia nigra pars reticulata neurons.

    Science.gov (United States)

    Higgs, Matthew H; Wilson, Charles J

    2016-06-01

    Neurons in substantia nigra pars reticulata (SNr) are synaptically coupled by local axon collaterals, providing a potential mechanism for local signal processing. Because SNr neurons fire spontaneously, these synapses are constantly active. To investigate their properties, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from SNr neurons in brain slices, in which afferents from upstream nuclei are severed, and the cells fire rhythmically. The sIPSC trains contained a mixture of periodic and aperiodic events. Autocorrelation analysis of sIPSC trains showed that a majority of cells had one to four active unitary inputs. The properties of the unitary IPSCs (uIPSCs) were analyzed for cells with one unitary input, using a model of periodic presynaptic firing and stochastic synaptic transmission. The inferred presynaptic firing rates and coefficient of variation of interspike intervals (ISIs) corresponded well with direct measurements of spiking in SNr neurons. Methods were developed to estimate the success probability, amplitude distributions, and kinetics of the uIPSCs, while removing the contribution from aperiodic sIPSCs. The sIPSC amplitudes were not increased upon release from halorhodopsin silencing, suggesting that most synapses were not depressed at the spontaneous firing rate. Gramicidin perforated-patch recordings indicated that the average reversal potential of spontaneous inhibitory postsynaptic potentials was -64 mV. Because of the change in driving force across the ISI, the unitary inputs are predicted to have a larger postsynaptic impact when they arrive late in the ISI. Simulations of network activity suggest that this very sparse inhibitory coupling may act to desynchronize the activity of SNr neurons while having only a small effect on firing rate. PMID:26961101

  7. Características morfológicas da pars de C2 de humanos Características morfológicas de la pars de C2 de humanos Morphologic characteristics of C2 humans pars

    Directory of Open Access Journals (Sweden)

    Charles André Carazzo

    2009-09-01

    Full Text Available OBJETIVO: avaliar a morfometria da pars da segunda vértebra cervical, verificar as variações existentes e predizer sua segurança para a colocação de parafusos por meio de uma abordagem cervical posterior. MÉTODOS: 58 vértebras foram obtidas para estudo anatômico (116 pars de C2 e foram medidas a altura e largura da pars, além do comprimento eixo-pedículo, largura e comprimento do pedículo, angulação sagital e medial. Todas as medidas foram separadas quanto aos seus lados direito e esquerdo; foi realizado o cálculo da média, variação, desvio padrão e a médica foi comparada com os estudos prévios. RESULTADOS: a largura média da pars de C2 foi de 9,5 mm; a altura, 9,5 mm; não houve diferença significativa entre os lados esquerdo e direito. O comprimento médio do pedículo foi de 10,5 mm; a medida média encontrada para o comprimento eixo-pedículo foi de 24,9 mm; a largura do pedículo foi de 2,8 mm. A angulação sagital encontrada foi de 19,6º e a horizontal foi de 28,5º. CONCLUSÕES: este estudo demonstra a viabilidade para a colocação de parafuso na pars de C2 em uma população caucasiana, destacando-se, porém, a grande variabilidade anatômica encontrada nas referidas medidas.OBJETIVO: evaluar la morfometría de la pars de la segunda vértebra cervical, verificar las variaciones existentes y predecir su seguridad para la colocación de los tornillos por un abordaje cervical posterior. MÉTODOS: 58 vértebras fueron obtenidas para el estudio anatómico (116 pars de C2 y fueron medidas su altura y el ancho de las pars, además de la largura eje-pedículo, ancho y largura del pedículo, ángulo sagital y medial. Todas las medidas fueron separadas según sus lados derecho e izquierdo, se realizó el cálculo de la media, variación, desvío estándar y comparados los valores con estudios previos. RESULTADOS: el ancho promedio de la pars de C2 fue de 9.5 mm, la altura de 9.5 mm, sin diferencia significativa entre los

  8. ON THE PAR REDUCTION OF MB-OFDM ULTRA-WIDEBAND SIGNALS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The Peak to Average power Ratio (PAR) of a Multi-Band Orthogonal Frequency-Division Multi-plexing (MB-OFDM) Ultra-Wide Band (UWB) signals can be substantially larger than that of single carrieror carrier-less ultra-wideband signals. In this letter, a novel PAR reduction scheme for the MB-OFDM UWBsystem based on spreading and interleaving is proposed. By spreading the coded bits over each subcarrier incorresponding band and interleaving the spread symbols across all bands, the PAR statistics of theMB-OFDM signals can be improved and the PAR is reduced obviously. In the PAR reduction scheme, there isno loss in transmission data rate or Bit Error Rate (BER) performance decreasing. Since the spreading andinterleaving operation are implemented by unitary Hadamard sequences and used for an approach to providethe robustness of the UWB system to narrowband interference, there is no additional implementation burden.Simulation results show that the investigated scheme gives the PAR reduction of 3dB compared with that ofthe original MB-OFDM signals.

  9. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  10. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.

    Science.gov (United States)

    Loughner, Chelsea L; Bruford, Elspeth A; McAndrews, Monica S; Delp, Emili E; Swamynathan, Sudha; Swamynathan, Shivalingappa K

    2016-01-01

    Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members. PMID:27098205

  11. A Dual Mechanism Controls Nuclear Localization in the Atypical Basic-Helix-Loop-Helix Protein PAR1 of Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Anahit Galstyan; Jordi Bou-Torrent; Irma Roig-Villanova; Jaime F. Martínez-García

    2012-01-01

    PAR1 is an atypical basic-helix-loop-helix (bHLH) protein that negatively regulates the shade avoidance syndrome in Arabidopsis thaliana acting as a transcriptional cofactor.Consistently with this function,PAR1 has to be in the nucleus to display biological activity.Previous structure-function analyses revealed that the N-terminal region of PAR1 drives the protein to the nucleus.However,truncated forms of PAR1 lacking this region still display biological activity,implying that PAR1 has additional mechanisms to localize into the nucleus.In this work,we compared the primary structure of PAR1 and various related and unrelated plant bHLH proteins,which led us to suggest that PAR1 contains a non-canonical nuclear localization signal (NLS) in the N-terminal region.By overexpressing truncated and mutated derivatives of PAR1,we have also investigated the importance of other regions of PAR1,such as the acidic and the extended HLH dimerization domains,for its nuclear localization.We found that,in the absence of the N-terminal region,a functional HLH domain is required for nuclear localization.Our results suggest the existence of a dual mechanism for PAR1 nuclear localization:(1) one mediated by the N-terminal non-consensus NLS and (2) a second one that involves interaction with other proteins via the dimerization domain.

  12. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-03-01

    Full Text Available [Français] L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté. [English] The use of the Web presented in this article supports a teaching approach based on knowledge sharing. Within the context of an industrial simulation, the students in an advanced programming course must learn to share their expertise, to communicate their questions clearly, to describe problems, and to deal with unexpected reversals. The Web becomes a collaborative space for disseminating the requests of a fictional client, along with directives, preliminary studies, and agreements. The results obtained tend to suggest that this global approach forces the student to plan better, increases the level of cooperation, facilitates the production of analogies, and invites the students to improve how they formulate and describe their problems. A system that facilitates the logistics of peer review (retrieving assignments, constructing an evaluation chart, and disseminating results is also presented.

  13. Transcription factor network downstream of protease activated receptors (PARs modulating mouse bladder inflammation

    Directory of Open Access Journals (Sweden)

    Hurst Robert E

    2007-08-01

    Full Text Available Abstract Background All four PARs are present in the urinary bladder, and their expression is altered during inflammation. In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders. Methods For this purpose, we used a protein/DNA combo array containing 345 different TF consensus sequences. Next, the TF selected was validated by EMSA and IHC. As mast cells seem to play a fundamental role in bladder inflammation, we determined whether c-kit receptor deficient (Kitw/Kitw-v mice have an abrogated response to PAR stimulation. Finally, TFEB antibody was used for CHIP/Q-PCR assay and revealed up-regulation of genes known to be downstream of TFEB. Results TFEB, a member of the MiTF family of basic helix-loop-helix leucine zipper, was the only TF commonly up-regulated by all PAR-APs. IHC results confirm a correlation between inflammation and TFEB expression in C57BL/6 mice. In contrast, Kitw/Kitw-v mice did not exhibit inflammation in response to PAR activation. EMSA results confirmed the increased TFEB binding activity in C57BL/6 but not in Kitw/Kitw-v mice. Conclusion This is the first report describing the increased expression of TFEB in bladder inflammation in response to PAR activation. As TFEB belongs to a family of TFs essential for mast cell survival, our findings suggest that this molecule may influence the participation of mast cells in PAR-mediated inflammation and that targeting TFEB/MiTF activity may be a novel approach for the treatment of bladder inflammatory disorders.

  14. Detecting Plant Photoprotective Response to Water Stress Through Variation In PAR Reflectance

    Science.gov (United States)

    Zygielbaum, A. I.; Arkebauer, T. J.; Walter-Shea, E.

    2012-12-01

    Published papers over several decades have shown increasing leaf-level optical reflectance with decreasing leaf water content. Our experimental results using maize and sorghum showed this increase consistently, caused by variation in optical absorption, in the visible (photosynthetically active radiation - PAR) and middle infrared (MIR) spectral regions. Relatively smaller response, driven by variation in optical scatter, was observed in near infrared (NIR). The concomitant increasing reflectance in the PAR and MIR regions is perplexing. PAR reflectance is dominated by chlorophyll absorption while MIR reflectance is dominated by water molecule absorption. However, changes in chlorophyll concentration, determined by chemical extraction, were too small to account for the variation in PAR reflectance. PAR and MIR reflectances were also influenced by the strength of incident light. Hence PAR reflectance appears to be modulated not only by pigment concentration, the classical description, but also by the strength of incident light and the severity of water deficit. We previously reported that these findings were consistent with chloroplast avoidance movement, a plant photoprotective response, which limits light absorption by pigments. We report here our continuing investigation of this phenomenon. In addition to reflectance measurements, time-lapse microscope images of leaves under increasing water deficit conditions were obtained. These show a brightening between veins which strongly supports our assertion that changes in PAR reflectance accompanying water deficit are caused primarily by chloroplast avoidance movement. Our results suggest that leaf, and possibly canopy, reflectance can therefore be used to detect and measure plant stress. These results also indicate that chloroplast avoidance movement may cause poor estimates of leaf chlorophyll content using techniques based on fluoresced, reflected or transmitted light.

  15. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Directory of Open Access Journals (Sweden)

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  16. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily Kara

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  17. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  18. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  19. Simulation d'une structure générique RC-IGBT sans "tension de retournement" adaptée à l'intégration monolithique de cellules de commutation sur puce Si

    OpenAIRE

    Lale, Adem; Bourennane , Abdelhakim; El khadiry, Abdelilah; Richardeau, Frédéric

    2014-01-01

    Une structure IGBT à conduction inverse (RC- IGBT) qui intègre de manière monolithique un IGBT pour la conduction directe et un thyristor auto-amorçable pour la conduction inverse est proposée. Contrairement au RC-IGBT classique, cette nouvelle structure ne présente pas de snapback [1-2] en mode de conduction direct. Le fonctionnement du RC- IGBT que nous proposons a été étudié par des simulations physiques 2D en statique et en dynamique. La structure proposée est ensuite utilisée pour créer ...

  20. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  1. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  2. Infantile maxillary sinus osteomyelitis mimicking orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Nagarajan Krishnan

    2014-01-01

    Full Text Available Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococcus aureus growth and the child improved with intravenous cloxacillin therapy. This case is presented due to the rarity of its presentation in this age group and for awareness to consider this entity in children having fever and peri-orbital swelling.

  3. Infantile Maxillary Sinus Osteomyelitis Mimicking Orbital Cellulitis

    OpenAIRE

    Nagarajan Krishnan; Nathan Ramamoorthy; Suresh Panchanathan; Balasundaram, Jothiramalingam S

    2014-01-01

    Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococc...

  4. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature. PMID:25763844

  5. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  6. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer. PMID:26897170

  7. Protease-activated receptors (PARs) in cancer: Novel biased signaling and targets for therapy.

    Science.gov (United States)

    Bar-Shavit, R; Maoz, M; Kancharla, A; Jaber, M; Agranovich, D; Grisaru-Granovsky, S; Uziely, B

    2016-01-01

    Despite the fact that G protein-coupled receptors (GPCRs) mediate numerous physiological processes and represent targets for therapeutics for a vast array of diseases, their role in tumor biology is under appreciated. Protease-activated receptors (PARs) form a family which belongs to GPCR class A. PAR1&2 emerge with a central role in epithelial malignancies. Although the part of PAR1&2 in cancer is on the rise, their underlying signaling events are poorly understood. We review hereby past, present, and future cancer-associated PAR biology. Mainly, their role in physiological (placenta-cytotophobalst) and patho-physiological invasion processes. The identification and characterization of signal pleckstrin homology (PH)-domain-binding motifs established critical sites for breast cancer growth in PAR1&2. Among the proteins found to harbor important PH-domains and are involved in PAR biology are Akt/PKB as also Etk/Bmx and Vav3. A point mutation in PAR2, H349A, but not R352A, abrogated PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumor growth in vivo as also placental extravillous trophoblast (EVT) invasion in vitro is markedly reduced. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind PH-domain, inhibits mammary tumors and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26928551

  8. uPAR as anti-cancer target: evaluation of biomarker potential, histological localization, and antibody-based therapy

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Sørensen, Tine Thurison; Christensen, Ib J; Hoyer-Hansen, Gunilla

    2011-01-01

    action of several proteolytic systems in generation of a high proteolytic potential required for tissue remodeling processes. uPAR is additionally cleaved by uPA on the cell surface, liberating domain I, resulting in abrogated pericellular proteolysis. The expression of both uPAR and uPA is significantly...... hepatic fibrinolysis using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  9. L'offre d'information volontaire par Internet et le gouvernement des entreprises françaises

    OpenAIRE

    Li, Li

    2010-01-01

    (VF)Cette recherche analyse le phénomène de la diffusion d’information par Internet en France. En prolongeant les études antérieures sur l’offre volontaire d’information, nous cherchons à savoir comment les facteurs du gouvernement d’entreprise influent sur la communication par voie électronique. Nous examinons également l’impact des caractéristiques des entreprises sur la publication volontaire par Internet. Les résultats montrent que l’offre d’information par Internet s’accroît lorsque la s...

  10. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  11. Transmission and Distribution of Photosymthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7216-050] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  12. Transmission and Distribution of Photosynthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7226-270] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  13. Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation

    Directory of Open Access Journals (Sweden)

    Chen Chen-wen

    2012-06-01

    Full Text Available Abstract Activated microglia exerts both beneficial and deleterious effects on neurons, but the signaling mechanism controlling these distinct responses remain unclear. We demonstrated that treatment of microglial cultures with the PAR-2 agonist, 2-Furoyl-LIGRLO-NH2, evoked early transient release of BDNF, while sustained PAR-2 stimulation evoked the delayed release of inflammatory cytokines (IL-1β and TNF-α and nitric oxide. Culture medium harvested during the early phase (at 1 h of microglial activation induced by 2-Furoyl-LIGRLO-NH2 (microglial conditioned medium, MCM had no deleterious effects on cultured neurons, while MCM harvested during the late phase (at 72 h promoted DNA fragmentation and apoptosis as indicated by TUNEL and annexin/PI staining. Blockade of PAR-1 during the early phase of PAR-2 stimulation enhanced BDNF release (by 11%, small but significant while a PAR-1 agonist added during the late phase (24 h after 2-Furoyl-LIGRLO-NH2 addition suppressed the release of cytokines and NO. The neuroprotective and neurotoxic effects of activated microglial exhibit distinct temporal profiles that are regulated by PAR-1 and PAR-2 stimulation. It may be possible to facilitate neuronal recovery and repair by appropriately timed stimulation and inhibition of microglial PAR-1 and PAR-2 receptors.

  14. Ataque de viento externo con manifestaciones de parálisis facial periférica tratado con acupuntura

    OpenAIRE

    Pinzón Ramírez, Betty Alejandra

    2012-01-01

    El ataque de viento externo es considerado desde la medicina china como un síndrome patológico que puede cursar con manifestaciones de parálisis facial semejante a la parálisis de Bell o parálisis facial idiopática de la medicina occidental, la cual también es efectivamente tratada con acupuntura; sin embargo en la actualidad no hay estudios al respecto en nuestra población. El objetivo es describir las características de población, presentación y evolución de la parálisis facial asociada ...

  15. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion

    International Nuclear Information System (INIS)

    In addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mechanism of action in the invasion, metastasis, and proliferation process in gastric cancer have yet to be completely elucidated. Here, we analyzed the relationship between PAR1 activation, proliferation, invasion, and the signaling pathways downstream of PAR1 activation in gastric cancer. We established a PAR1 stably transfected MKN45 human gastric cancer cell line (MKN45/PAR1) and performed cell proliferation and invasion assays employing this cell line and MKN28 cell line exposed to PAR1 agonists (α-thrombin and TFLLR-NH2). We also quantified NF-κB activation by electrophoretic mobility shift assay (EMSA) and the level of Tenascin-C (TN-C) expression in conditioned medium by ELISA of MKN45/PAR1 following administration of α-thrombin. A high molecular weight concentrate was derived from the resultant conditioned medium and subsequent cultures of MKN45/PAR1 and MKN28 were exposed to the resultant concentrate either in the presence or absence of TN-C-neutralizing antibody. Lysates of these subsequent cells were probed to quantify levels of phospholyrated Epidermal Growth Factor Receptor (EGFR). PAR1 in both PAR1/MKN45 and MKN28 was activated by PAR1 agonists, resulting in cell proliferation and matrigel invasion. We have shown that activation of NF-κB and EGFR phosphorylation initially were triggered by the activation of PAR1 with α-thrombin. Quantitative PCR and Western blot assay revealed up-regulation of mRNA and protein expression of NF-κB target genes, especially TN-C, a potential EGFR activator. The suppressed level of phosphorylated EGFR, observed in cells exposed to concentrate of conditioned medium in the presence of TN-C-neutralizing antibody, identifies TN-C as a putative autocrine stimulatory factor of EGFR possibly involved in the sustained

  16. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L; Hansen, Tine W; Olsen, Michael H; Andersen, Ove; Linneberg, Allan; Madsbad, Sten; Haugaard, Steen B; Eugen-Olsen, Jesper; Jeppesen, Jørgen

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of...... the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body...... mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  17. Evaluation du risque de renversement de poids lourds par indice de fiabilité

    OpenAIRE

    Sellami, Yamine; Imine, Hocine; CADIOU, Jean Charles; ELHADRI, Abdelhafid

    2008-01-01

    Cet article présente une nouvelle méthode pour évaluer et prédire dynamiquement le risque de renversement de poids lourds par une approche fiabiliste. La méthode est basée sur la prise en compte des incertitudes du système. Les paramètres les plus influents sur le risque sont représentés par des variables aléatoires, alors que les variables dynamiques sont estimées par un filtre de Kalman Unscented, dédié aux systèmes non linaires. L'ensemble des variables aléatoires obtenues est utilisé pour...

  18. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  19. Modélisation du procédé de soudage par points

    OpenAIRE

    Srikunwong, Chainarong

    2005-01-01

    Parmi les procédés de soudage, la simulation numérique du soudage par résistance électrique par points offre l'avantage d'un calcul direct des sources de chaleur par couplage électro-thermique. En revanche, les données nécessaires pour décrire les contacts sont rares et difficiles à mesurer. Comme pour les autres procédésde soudage, la difficulté principale en simulation numérique est la disponibilité de données d'entrée à toutes températures depuis l'ambiante jusqu'au-delà de la fusion. Le c...

  20. Excrétion de carbone organique par le phytoplancton lémanique

    OpenAIRE

    Feuillade, M.; Dufour, Philippe; Feuillade, J.; Pelletier, J P

    1986-01-01

    L'excrétion du carbone organique dissous par le phytoplancton du lac Léman a été évaluée par la méthode du 14C entre mars et novembre 1984. Elle varie entre 0,01 et 0,5 mgC.m-3.h-1 et dépend en premier lieu de la vitesse d'assimilation photosynthétique. L'excrétion carbonée oscille généralement entre 2 et 5% de l'assimilation carbonée et n'excède qu'exceptionnellement 6%. Les valeurs sont sous-estimées par la réassimilation hétérotrophe. L'excrétion nocturne représente moins de 10% des pertes...

  1. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W;

    2011-01-01

    the first positive blood culture for S. aureus, suPAR levels were higher in 19 fatalities (median 12.3; range 5.7-64.6 ng/mL) than in 40 survivors (median 8.4; range 3.7-17.6 ng/mL, p = 0.002). This difference persisted for 10 days. The presence of deep infection focus was not associated with elevated su...... are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after...

  2. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  3. Correlación de parámetros geotécnicos con parámetros de un modelo hidrológico superficial.

    Directory of Open Access Journals (Sweden)

    Carlos Andres Caro Camargo

    2014-07-01

    Full Text Available Este artículo presenta la relación entre parámetros geotécnicos básicos y parámetros del modelo hidrológico de Thomas para balance hídrico de cuencas hidrográficas rurales. Esta relación funciona como una aplicación metodológica de calibración, herramienta útil en modelos distribuidos como es el caso de IBER, que representa un sistema distribuido de simulación numérica para flujo no permanente en lámina libre. Se realizó una exploración en 25 puntos (en 15 subcuencas de la cuenca de Rio de Piedras (Boyacá, obteniendo muestras de suelo a las cuales se les realizó caracterización geotécnica mediante ensayos de laboratorio.

  4. ÉTUDE, PAR LA MÉTHODE DES RADIOTRACEURS, DE LA DIFFUSION DU FER DANS LE SILICIURE DE FER Fe3Si OBTENU PAR CVD

    OpenAIRE

    Audisio, S.; Guiraldenq, P.

    1989-01-01

    Après obtention par CVD d'un revêtement de 50 à 80 µm de siliciure de fer Fe3Si sur substrat de fer, les coefficients d'autodiffusion du fer dans le siliciure ont été déterminés par la méthode des radiotraceurs de KRIVKOV et JHOUKHOVITSKY. Ces coefficients, 3.3 10-12 cm2/s à 815 °C et 1.6 10-11 cm2/s à 935 °C sont légèrement inférieurs à ceux de l'autodiffusion du fer α. Cette différence est attribuée aux liaisons entre les atomes dans le siliciure Fe3Si.

  5. Helicophyllaceae (Bryophyta, nova ocorrência para o Estado do Pará, Brasil Helicophyllaceae (Bryophyta, a new record to Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina C. L. Lisboa

    2005-09-01

    Full Text Available Helicophyllaceae, família monotípica neotropical, é registrada pela primeira vez no Estado do Pará. Sua única espécie, Helicophyllum torquatum (Hook. Brid., registrada anteriormente no Estado do Amazonas e que recentemente havia sido excluída da lista de musgos amazônicos, é apresentada como nova ocorrência para toda a Amazônia brasileira.Helicophyllaceae, a monotypic family of Neotropics, is presented for the Pará State. Helicophyllum torquatum (Hook. Brid., the single species, was recorded for the Amazonas State, but recently was excluded of checklist of Amazonian mosses. H. torquatum is considered a new report for all Brazilian Amazônia.

  6. Analysis of some sepsis markers: C-reactive protein, Procalcitonin, Osteopontin and suPAR

    Directory of Open Access Journals (Sweden)

    Ilaria Crespi

    2010-09-01

    Full Text Available Sepsis appears to be due to an uncontrolled pro and anti-inflammatory response leading to organ dysfunction until shock and death.Accuracy of diagnosis and appropriate treatment affect the outcome. Aim of the study was to investigate if the levels of Osteopontin (OPN and Soluble Urokinase-type Plasminoge Activator Receptor (suPAR might be early markers of sepsis and if these markers play a role in predicting the progression to septic shock. Methods:The levels of OPN, suPAR, C-reactive protein (CRP and procalcitonin (PCT were measured in patients at higher risk of infection. The samples were collected from the day of admission for the following fifteenth day. During recovery Sistemic Inflammatory Response Syndrome (SIRS criteria, blood chemistry data, blood gas- analysis, lactate and diuresis were collected. Microbiological culture were performed according to the clinical condition. Results: 29 patients were enrolled in the study, including 14 subjects with positive blood cultures.The values of OPN, PCT, suPAR and CRP were significantly increased in patients with positive blood cultures than those with negative blood cultures.Analysing changes of the levels of OPN, suPAR, PCT and CRP in patients with septic shock, the values of OPN increased in advance to the clinical diagnosis of septic shock, while the values of suPAR and PCT slight delay compared to those OPN.The levels of CRP were independent from the onset of septic shock state. Conclusions: These preliminary data suggest that Osteopontin and suPAR can be used as early markers of sepsis and might be useful in monitoring of septic outcome to predict a possible evolution to septic shock.

  7. Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway

    OpenAIRE

    Dormoy, Valérian; Tormanen, Kati; Sütterlin, Christine

    2013-01-01

    The centrosome contains two centrioles that differ in age, protein composition and function. This non-membrane bound organelle is known to regulate microtubule organization in dividing cells and ciliogenesis in quiescent cells. These specific roles depend on protein appendages at the older, or mother, centriole. In this study, we identified the polarity protein partitioning defective 6 homolog gamma (Par6γ) as a novel component of the mother centriole. This specific localization required the ...

  8. Perspectives de développement de la production industrielle d'hydrogène par électrolyse alcaline avancée Development Outlook for Industrial Hydrogen Production by Advanced Alkaline Electrolysis

    Directory of Open Access Journals (Sweden)

    Derive C.

    2006-11-01

    Full Text Available Dans les conditions du développement du programme nucléaire français qui permettent une production d'électricité à un coût intéressant en heures creuses, la production d'hydrogène par électrolyse de l'eau peut être envisagée à moyen terme en compétition avec les autres procédés de fabrication d'hydrogène tels que le reformage de gaz naturel. Dans le cadre de leur coopération, Électricité de France (EDF et le Gaz de France (GDF conduisent, depuis 1976, un programme de recherches et développement sur la production d'hydrogène par électrolyse alcaline de l'eau ayant pour but, par comparaison avec des installations existantes, de réduire le coût d'investissement et de conserver un rendement identique. Les études préalables ont montré que ces objectifs pouvaient être atteints par une électrolyse avancée avec élévation de la densité de courant et de la température. Ces contraintes techniques ont conduit EDF et le GDF à lancer des études sur la tenue chimique et la résistance mécanique des matériaux, sur une sélection de composants de cellules adaptés et sur l'amélioration de la conception d'ensemble des installations. Les deux groupements industriels français - pilotés par Alsthom-Atlantique et Creusot-Loire - associés à ces travaux depuis 1979, ont fixé les conditions de fonctionnement suivantes : - électrolyte à base de potasse (40 % en masse; - température de 120 et 160°C; - pression de 30 et 70 bar. Dans un premier temps, les constructeurs ont réalisé une étude technico-économique sur la production massive d'hydrogène à partir d'usines de puissance d'environ 300 MWe, fourni les plans de détail d'une installation pilote de 2 MWe et entrepris la qualification de leurs choix technologiques sur des boucles-prototypes de 25-30 kWe. Afin de valider plus complètement les choix retenus et d'approfondir les problèmes d'extrapolation à des électrolyseurs de grande taille, les essais sur boucles

  9. Volume equation as basis of community forest management in Anapu, Pará State, Brazil

    OpenAIRE

    Wallacy Ferreira Barreto; Fábio Miranda Leão; Marlon Costa de Menezes; Deivison Venicio Souza

    2014-01-01

    The community forest management in settlement areas, in Pará, needs tools that provide reliable information about wood potential in the area, as volume equations. Five volumetric models of simple entrance and five of double entrance were adjusted to estimate the wood volume of standing trees in the Project of sustainable development Virola-Jatobá in Anapu, Pará State, Brazil. The trees were cubed using Smalian method. The diameter at 1.3 m above soil level was measured in 172 individuals from...

  10. CARACTÉRISATION DU PHOTO-NOIRCISSEMENT DES FIBRES OPTIQUES DOPÉES YTTERBIUM PAR THERMOLUMINESCENCE

    OpenAIRE

    Mady, Franck; Benabdesselam, Mourad; Mebrouk, Yasmine; Blanc, Wilfried; Dussardier, Bernard

    2010-01-01

    Ce travail démontre l'intérêt de la thermoluminescence, une technique particulièrement adaptée à la caractérisation des défauts et centres ionisés par les radiations dans des préformes de fibres optiques en silice dopées ytterbium. Le rôle des ions Yb3+ dans l'absorption des radiations et celui des porteurs délocalisés par photo-ionisation dans l'absorption optique induite sont notamment précisés.

  11. DETECTION ET IDENTIFICATION DES ARYTHMIES CARDIAQUES PAR APPLICATION DES RESEAUX DE NEURONES

    OpenAIRE

    BELGACEM, N.; M.A Chikh; BEREKSI REGUIG, F.

    2003-01-01

    L’électrocardiographie explore l’activité électrique du coeur par enregistrement des variations des ondes électriques de l’activité de polarisation et de dépolarisation ventriculaire et auriculaires du coeur. L’activité cardiaque constitue l’un des plus importants paramètres déterminant l’état d’un sujet. Elle se traduit par l’apparition de plusieurs ondes sur le tracé de l’électrocardiographe : c’est le signal cardiaque, l’électrocardiogramme : ECG. L'analyse du signal ECG et l'i...

  12. Capacidad de salto en futbolistas con parálisis cerebral

    OpenAIRE

    Yanci, J; Los Arcos, A.; Grande, I.; Santalla, A; Figueroa, J; Gil, E.; Cámara, J.

    2014-01-01

    Los objetivos del presente estudio fueron determinar en jugadores de fútbol con parálisis cerebral la altura de vuelo durante la realización del salto sin contramovimiento y con contramovimiento, y observar la relación de las variables antropométricas y de la clase funcional con la altura de vuelo y con el índice elástico. Trece jugadores de fútbol 7 diagnosticados con parálisis cerebral participaron en el estudio. La altura de vuelo durante el salto sin contramovimiento (20.45±4.45 cm) y con...

  13. Propuesta de registro fonológico en personas adultas con parálisis cerebral

    OpenAIRE

    Revuelta Carpintero, Sara Fátima

    2015-01-01

    El presente trabajo refiere la creación de un registro fonológico dirigido a la población adulta con parálisis cerebral. Esta patología muestra, aparte de otros síntomas, una deficiencia en el proceso articulatorio del lenguaje, ya que presentan muchas dificultades a nivel motor y/o sensorial, cursando con espasticidad, atetosis, ataxia o la unión de éstos. Es importante reflejar la asociación existente entre la parálisis cerebral y los trastornos articulatorios, los cuales son un...

  14. La competencia comunicativa en personas que presentan par??lisis cerebral

    OpenAIRE

    Rosada Ayala, J. I.

    2012-01-01

    A pesar de los numerosos intentos por definir universalmente la Par??lisis Cerebral, todav??a no se ha conseguido una definici??n que una todas las opiniones acerca de ??sta, aunque s?? existen puntos en com??n en la mayor??a de ellas. Todas las personas, para poder desenvolverse en su contexto social, deben desarrollar su capacidad de comunicaci??n, especialmente las personas con par??lisis cerebral. Esta capacidad se debe potenciar, desde el desarrollo de la lengua por parte de los centr...

  15. Acquisition 3D des gestes par vision artificielle et restitution virtuelle

    OpenAIRE

    Gomez Jauregui, David Antonio

    2011-01-01

    Les environnements virtuels collaboratifs permettent à plusieurs utilisateurs d’interagir à distance par Internet. Ils peuvent partager une impression de téléprésence en animant à distance un avatar qui les représente. Toutefois, le contrôle de cet avatar peut être difficile et mal restituer les gestes de l’utilisateur. Ce travail vise à animer l’avatar à partir d’une acquisition 3D des gestes de l’utilisateur par vision monoculaire en temps réel, et à rendre la téléprésence virtuelle possibl...

  16. PARma: identification of microRNA target sites in AGO-PAR-CLIP data.

    Science.gov (United States)

    Erhard, Florian; Dölken, Lars; Jaskiewicz, Lukasz; Zimmer, Ralf

    2013-01-01

    PARma is a complete data analysis software for AGO-PAR-CLIP experiments to identify target sites of microRNAs as well as the microRNA binding to these sites. It integrates specific characteristics of the experiments into a generative model. The model and a novel pattern discovery tool are iteratively applied to data to estimate seed activity probabilities, cluster confidence scores and to assign the most probable microRNA. Based on differential PAR-CLIP analysis and comparison to RIP-Chip data, we show that PARma is more accurate than existing approaches. PARma is available from http://www.bio.ifi.lmu.de/PARma. PMID:23895117

  17. Représentation par objets et classification pour le raisonnement à partir de cas

    OpenAIRE

    Lieber, Jean; Napoli, Amedeo

    1998-01-01

    Dans cet article, nous proposons une analyse du raisonnement à partir de cas ---\\rapc --- dans le cadre des représentations de connaissances par objets. Nous montrons les rapports existant entre le \\rapc et le processus de classification, nous mettons en valeur les classifications dure et élastique, qui interviennent lors de l'opération de remémoration dans le cycle du \\rapc, ainsi que la notion de chemin de similarité, qui intervient lors de l'étape d'adaptation. l'article se termine par une...

  18. Le Sycoscan : un système d'inspection des conteneurs par balayage radioscopique

    CERN Multimedia

    Krystal Production

    1997-01-01

    La société Europ Scan, le port autonome du Havre et les douanes françaises ont conçu un système de contrôle par rayons X qui permet d’étudier par radiographie le contenu d'un chargement. Les conteneurs sont ainsi vérifiés sans être déchargés ou ouverts. On utilise des faisceaux de rayons X de faible énergie couplés à des détecteurs ultrasensibles inspirés de la chambre à fils de Georges Charpak.

  19. F-actin-like filaments formed by plasmid segregation protein ParM

    DEFF Research Database (Denmark)

    van den Ent, Fusinita; Møller-Jensen, Jakob; Amos, Linda A.;

    2002-01-01

    of Escherichia coli formed by ParM, a plasmid-encoded protein required for accurate segregation of low-copy-number plasmid R1. We show here that ParM polymerizes into double helical protofilaments with a longitudinal repeat similar to filamentous actin (F-actin) and MreB filaments that maintain the cell shape...... compared with F-actin, despite the similar arrangement of the subunits within the filaments. Thus, there is now evidence for cytoskeletal structures, formed by actin-like filaments that are involved in plasmid partitioning in E.coli. Udgivelsesdato: Dec 16...

  20. Software para el cálculo de parámetros en superficies planas vibratorias

    Directory of Open Access Journals (Sweden)

    Augusto Dongua

    2014-01-01

    Full Text Available Se presenta el programa “CRIBAS II” para el cálculo de los principales parámetros de diseño y operación de las superficies planas vibratorias empleadas para la limpieza, clasificación y transportación de productos agrícolas. El software posibilita calcular los parámetros del régimen vibratorio a aplicar a la superficie (frecuencia, amplitud y dirección de las vibraciones en función de obtener el desplazamiento deseado para las partículas procesadas, durante su movimiento sobre la superficie.

  1. Élimination des micropolluants par les stations d'épuration domestiques

    OpenAIRE

    Choubert, J.M.; Pomies, M.; Miège, C.; Martin Ruel, S.; Budzinski, H.; Wisniewski, C.; Coquery, M.

    2012-01-01

    Les stations d'épuration domestiques n'ont pas été conçues pour traiter les micropolluants. Elles en éliminent cependant une quantité non négligeable, essentiellement par sorption sur les boues, associée à une dégradation par voie biologique pour certaines substances. Cet article synthétise les principaux acquis récents concernant le comportement des micropolluants dans les filières de traitement des eaux (primaires, secondaires, tertiaires) et dans les filières boues associées. Il présente é...

  2. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis

    International Nuclear Information System (INIS)

    Rats pars intermedia cells were incubated for 3 h with the following amino-acids: a) 35S-methionine and 3H-phenylalamine; b) 3H-valine; and c) 3H-valine and 3H-lysine. Radioactive gamma-lipotropin, beta-lipotropin and beta-endorphin were purified on carboxy- methyl-cellulose and characterized by polyacrylamide disc gel electrophoresis af pH 4.5, molecular weight estimation and microsequencing. Rat gamma-lipotropin was shown to differ slightly from ovine gamma-lipotropin in its NH2-terminal amino acid sequence, in containing no methionine and having phenylalanine at position 6, valine at positions 13 and 27, and lysine at position 20. The same variations were observed in the sequence of rat beta-lipotropin, while rat beta-endorphin was shown to be identical to the ovine beta-endorphin. Following a 3-h pulse of rat pars distalis, the cells were extracted with care to avoid beta-lipotropin degradation by proteolytic enzymes. A peptide was purified and identified to be rat beta-endorphin, thus demonstrating that beta-endorphin is biosynthesized in pars distalis and is not an extraction artifact. (author)

  3. Nanotechnologie : conception à l'échelle atomique par Stéphane Redon. Dynamique moléculaire interactive, entretien avec Serge Crouzy, propos recueillis par Dominique Chouchan.

    OpenAIRE

    Redon, Stéphane; Crouzy, Serge

    2009-01-01

    National audience L'exploration et la manipulation de l'infiniment petit passeront sans doute par la conception assistée par ordinateur : le prototypage virtuel d'objets nanoscopiques concerne un grand nombre d'applications industrielles, pharmacologiques...

  4. Sécurité informatique : peut-on se fier au numérique ? par Hélène Kirchner et Claude Kirchner. Le sens des mots, entretien avec Isabelle de Lamberterie, propos recueillis par Dominique Chouchan.

    OpenAIRE

    Kirchner, Hélène; Kirchner, Claude; Lamberterie, Isabelle de

    2008-01-01

    National audience Dans le monde de l'immatériel, la prévention contre les indésirables passe par des outils logiciels. Leur conception par des méthodes formelles apporte des garanties de plus en plus sérieuses pour anticiper la virtuosité des intrus.

  5. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  6. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian;

    2010-01-01

    -suPAR), thereby exploring the possibility of replacing the blood sample with an easy obtainable urine sample. We enrolled 1,007 adults, older than 15 years of age, with a negative TB diagnosis between April 2004 and December 2006. Levels of U-suPAR and P-suPAR were available in 863 individuals. U-suPAR was...... measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives and...

  7. Modèle de tenségrité viscoélastique pour l'étude de la réponse dynamique des cellules adhérentes

    OpenAIRE

    Cañadas, Patrick

    2003-01-01

    Un modèle de tenségrité viscoélastique (MTV) composé de 6 barres quasi-rigides et de 24 câbles viscoélastiques est développé et son comportement mécanique est étudié dans les domaines temporel et fréquentiel pour comprendre le rôle joué par la déformation structurale du cytosquelette dans la réponse cellulaire en petites et grandes déformations. Des simulations numériques de tests de fluage ainsi que d'oscillations imposées sont effectuées, permettant d'établir des lois de dépendance entre d'...

  8. Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.

    OpenAIRE

    Perichon, B; Tankovic, J; Courvalin, P

    1997-01-01

    We report a mutation in the parE genes of two in vitro mutants of Streptococcus pneumoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyrA leads to higher levels of resistance. This confirms that topoisomerase IV is the primary target of fluoroquinolones in S. pneumoniae.

  9. MtPAR MYB transcription factor acts as an on switch for proanthocyanidin biosynthesis in Medicago truncatula.

    Science.gov (United States)

    Verdier, Jerome; Zhao, Jian; Torres-Jerez, Ivone; Ge, Shujun; Liu, Chenggang; He, Xianzhi; Mysore, Kirankumar S; Dixon, Richard A; Udvardi, Michael K

    2012-01-31

    MtPAR (Medicago truncatula proanthocyanidin regulator) is an MYB family transcription factor that functions as a key regulator of proanthocyanidin (PA) biosynthesis in the model legume Medicago truncatula. MtPAR expression is confined to the seed coat, the site of PA accumulation. Loss-of-function par mutants contained substantially less PA in the seed coat than the wild type, whereas levels of anthocyanin and other specialized metabolites were normal in the mutants. In contrast, massive accumulation of PAs occurred when MtPAR was expressed ectopically in transformed hairy roots of Medicago. Transcriptome analysis of par mutants and MtPAR-expressing hairy roots, coupled with yeast one-hybrid analysis, revealed that MtPAR positively regulates genes encoding enzymes of the flavonoid-PA pathway via a probable activation of WD40-1. Expression of MtPAR in the forage legume alfalfa (Medicago sativa) resulted in detectable levels of PA in shoots, highlighting the potential of this gene for biotechnological strategies to increase PAs in forage legumes for reduction of pasture bloat in ruminant animals. PMID:22307644

  10. Stabilizing a Flexible Interdomain Hinge Region Harboring the SMB Binding Site Drives uPAR into Its Closed Conformation

    DEFF Research Database (Denmark)

    Zhao, Baoyu; Gandhi, Sonu; Yuan, Cai;

    2015-01-01

    domains is inherently flexible and binding of uPA drives uPAR into its closed conformation, which presents the higher affinity state for vitronectin thus providing an allosteric regulatory mechanism. Using a new class of epitope mapped monoclonal anti-uPAR antibodies, we now demonstrate...

  11. Analysis of gyrA and parC mutations in enterococci from environmental samples with reduced susceptibility to ciprofloxacin

    DEFF Research Database (Denmark)

    Petersen, A.; Jensen, Lars Bogø

    2004-01-01

    The quinolone resistance determining regions of gyrA and parC in four species of enterococci from environmental samples with reduced susceptibility to ciprofloxacin were sequenced. The nucleotide sequence variations of parC could be related to the different enterococcal species. Mutations in...

  12. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  13. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  14. Parásitos de animales silvestres en cautiverio en Lima, Perú

    OpenAIRE

    Lily Arrojo

    2013-01-01

    Los parásitos de los animales silvestres en cautiverio peruanos se registran aquí. La mayoría de las especies son nematodos. Dos especies son al patógeno de host: Prosthenorchois elegans y Strongyloides sp.

  15. Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes.

    Science.gov (United States)

    Nikolaou, S; Gasser, R B

    2007-04-01

    Signal transduction molecules play key roles in the regulation of developmental processes, such as morphogenesis, organogenesis and cell differentiation in all organisms. They are organized into 'pathways' that represent a coordinated network of cell-surface receptors and intracellular molecules, being involved in sensing environmental stimuli and transducing signals to regulate or modulate cellular processes, such as gene expression and cytoskeletal dynamics. A particularly important group of molecules implicated in the regulation of the cytoskeleton for the establishment and maintenance of cell polarity is the PAR proteins (derived from partition defective in asymmetric cell division). The present article reviews salient aspects of PAR proteins involved in the early embryonic development and morphogenesis of the free-living nematode Caenorhabditis elegans and some other organisms, with an emphasis on the molecule PAR-1. Recent advances in the knowledge and understanding of PAR-1 homologues from the economically important parasitic nematode, Haemonchus contortus, of small ruminants is summarized and discussed in the context of exploring avenues for future research in this area for parasitic nematodes. PMID:17107637

  16. Update on the Role of Substantia Nigra Pars Reticulata in the Regulation of Seizures

    OpenAIRE

    Velíšková, Jana; Moshé, Solomon L.

    2006-01-01

    The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing system, which may be targeted to develop treatments for generalized or multifocal epilepsies. This review summarizes the region-, age-, and sex-specific features of the SNR-based seizure-controlling network.

  17. Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

    Czech Academy of Sciences Publication Activity Database

    Olejár, Tomáš; Větvička, D.; Zadinová, M.; Poučková, P.; Kukal, J.; Ježek, Petr; Matěj, R.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3511-3515. ISSN 0250-7005 R&D Projects: GA ČR(CZ) GAP302/10/0346 Institutional support: RVO:67985823 Keywords : PAR2 * melanoma * metastasis * murine model Subject RIV: EA - Cell Biology Impact factor: 1.826, year: 2014

  18. Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model

    Science.gov (United States)

    Hao, Wenrui; Friedman, Avner

    2016-01-01

    There are currently over 2.5 million breast cancer survivors in the United States and, according to the American Cancer Society, 10 to 20 percent of these women will develop recurrent breast cancer. Early detection of recurrence can avoid unnecessary radical treatment. However, self-examination or mammography screening may not discover a recurring cancer if the number of surviving cancer cells is small, while biopsy is too invasive and cannot be frequently repeated. It is therefore important to identify non-invasive biomarkers that can detect early recurrence. The present paper develops a mathematical model of cancer recurrence. The model, based on a system of partial differential equations, focuses on tissue biomarkers that include the plasminogen system. Among them, only uPAR is known to have significant correlation to its concentration in serum and could therefore be a good candidate for serum biomarker. The model includes uPAR and other associated cytokines and cells. It is assumed that the residual cancer cells that survived primary cancer therapy are concentrated in the same location within a region with a very small diameter. Model simulations establish a quantitative relation between the diameter of the growing cancer and the total uPAR mass in the cancer. This relation is used to identify uPAR as a potential serum biomarker for breast cancer recurrence. PMID:27078836

  19. Leuconychie transversale induite par la manucurie: y a-t-il un apport de la dermoscopie?

    Science.gov (United States)

    Gallouj, Salim; Mernissi, Fatima Zahra

    2014-01-01

    La leuconychie transversale induite par la manucurie est une leuconychie secondaire au microtraumatisme transmis à la matrice unguéale. Nous rapportant une observation où la dermoscopie avait un intérêt considérable pour l'orientation diagnostic. PMID:25368728

  20. Apprentissage par renforcement développemental pour la robotique autonome

    OpenAIRE

    Sarzyniec, Luc

    2010-01-01

    La problématique du stage porte sur l'apprentissage par renforcement appliqué à la robotique et plus particulièrement, l'apprentissage d'une tâche complexe divisée en plusieurs tâches plus simples.

  1. Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model.

    Science.gov (United States)

    Hao, Wenrui; Friedman, Avner

    2016-01-01

    There are currently over 2.5 million breast cancer survivors in the United States and, according to the American Cancer Society, 10 to 20 percent of these women will develop recurrent breast cancer. Early detection of recurrence can avoid unnecessary radical treatment. However, self-examination or mammography screening may not discover a recurring cancer if the number of surviving cancer cells is small, while biopsy is too invasive and cannot be frequently repeated. It is therefore important to identify non-invasive biomarkers that can detect early recurrence. The present paper develops a mathematical model of cancer recurrence. The model, based on a system of partial differential equations, focuses on tissue biomarkers that include the plasminogen system. Among them, only uPAR is known to have significant correlation to its concentration in serum and could therefore be a good candidate for serum biomarker. The model includes uPAR and other associated cytokines and cells. It is assumed that the residual cancer cells that survived primary cancer therapy are concentrated in the same location within a region with a very small diameter. Model simulations establish a quantitative relation between the diameter of the growing cancer and the total uPAR mass in the cancer. This relation is used to identify uPAR as a potential serum biomarker for breast cancer recurrence. PMID:27078836

  2. ParCYCLIC: finite element modelling of earthquake liquefaction response on parallel computers

    Science.gov (United States)

    Peng, Jun; Lu, Jinchi; Law, Kincho H.; Elgamal, Ahmed

    2004-10-01

    This paper presents the computational procedures and solution strategy employed in ParCYCLIC, a parallel non-linear finite element program developed based on an existing serial code CYCLIC for the analysis of cyclic seismically-induced liquefaction problems. In ParCYCLIC, finite elements are employed within an incremental plasticity, coupled solid-fluid formulation. A constitutive model developed for simulating liquefaction-induced deformations is a main component of this analysis framework. The elements of the computational strategy, designed for distributed-memory message-passing parallel computer systems, include: (a) an automatic domain decomposer to partition the finite element mesh; (b) nodal ordering strategies to minimize storage space for the matrix coefficients; (c) an efficient scheme for the allocation of sparse matrix coefficients among the processors; and (d) a parallel sparse direct solver. Application of ParCYCLIC to simulate 3-D geotechnical experimental models is demonstrated. The computational results show excellent parallel performance and scalability of ParCYCLIC on parallel computers with a large number of processors. Copyright

  3. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  4. Estructura diferenciable de las clases de equivalencia de un par controlable

    OpenAIRE

    Compta Creus, Albert; Ferrer Llop, Josep; Peña Carrera, Marta

    2007-01-01

    Dado un par de matrices que representa un sistema lineal controlable, estudiamos las clases de equivalencia por la acción individual o combinada de realimentaciones y cambio de variables de estado y de entrada, así como sus intersecciones. En particular, demostramos que son variedades diferenciables y calculamos sus dimensiones.

  5. SURGICALLY INDUCED ASTIGMATISM AFTER 20G VS 23G PARS PLANA VITRECTOMY

    OpenAIRE

    Lokabhi Reddy; Suneetha

    2015-01-01

    Pars Plana Vitrectomy is done to clear the Vitreous cavity of the Eye. Trans conjunctival Sutureless Vitrectomy with 23G & 25G has become more popular over the Conventional 20G Vitrectomy in recent times. It has many advantages. Less amount of Surgically Induc ed Astigmatism is one of the Advantages with Sutureless Vitrectomy, which wil...

  6. Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination

    DEFF Research Database (Denmark)

    Juncker-Jensen, Anna; Deryugina, Elena I; Rimann, Ivo;

    2013-01-01

    non-tumor-cell/non-matrix target, activation of which by carcinoma-produced MMP-1 regulates endothelial permeability and transendothelial migration. The inhibitory effects of specific PAR1 antagonists in live animals have also indicated that the mechanisms of MMP-1-dependent vascular permeability...

  7. PAR as a way of organising a social workers labour union in Greenland

    DEFF Research Database (Denmark)

    Andersen, John; Arnfjord, Steven

    Abstract, ALARA2015012:PAR as a way of organising a social workers labour union in Greenland for consideration and inclusion in the programme for the ALARA 9th Action Learning Action Research and 13th Participatory Action Research World Congress to be held at St. George Hotel and Conference Centre...

  8. Rational targeting of the urokinase receptor (uPAR): development of antagonists and non-invasive imaging probes

    DEFF Research Database (Denmark)

    Kriegbaum, Mette Camilla; Persson, Morten; Haldager, L; Alpizar, Warner Enrique Alpizar; Jacobsen, Benedikte; Gårdsvoll, H; Kjær, Andreas; Ploug, Michael

    2011-01-01

    PA-mediated plasminogen activation at the cell surface, which is accomplished by its high-affinity interaction with the growth factor-like domain of uPA. Detailed insights into the molecular basis underlying the interactions between uPAR and its two bona fide ligands, uPA and vitronectin, have been obtained recently by X......-ray crystallography and surface plasmon resonance studies. Importantly, these structural studies also define possible druggable target sites in uPAR for small molecules and provide guidelines for the development of reporter groups applicable for non-invasive molecular imaging of uPAR expression in vivo by positron...... emission tomography. In this review, we will discuss recent advances in our perception of the structure-function relationships of uPAR ligation and how these may assist translational research in preclinical intervention studies of uPAR function....

  9. Caractérisation d'un alliage 2024-T3 assemblé par friction-malaxage

    OpenAIRE

    JEMAL, Nejah; MASSE, Jean-Eric; LANGLOIS, Laurent; TCHERNIAEFF, Serge; GIROT, Franck

    2010-01-01

    Le procédé Friction Stir Welding qui peut se traduire en français par friction malaxage a été inventé par le TWI de Cambridge en 1991. La soudure est réalisée par apport de chaleur provoqué par le frottement d'un outil en rotation et mis en pression sur la pièce. Ce procédé intéresse les utilisateurs d'alliages légers car, sans passer par la fusion, il permet le soudage d'alliages à haute résistance, jusque là inutilisables en raison de leur soudabilité difficile avec les procédés traditionne...

  10. Caractérisation d'un alliage 2024-T3 assemblé par friction-malaxage

    OpenAIRE

    JEMAL, Nejah; MASSE, Jean-Eric; LANGLOIS, Laurent; TCHERNIAEFF, Serge; GIROT, Franck

    2010-01-01

    Le procédé Friction Stir Welding qui peut se traduire en français par friction malaxage a été inventé par le TWI de Cambridge en 1991. La soudure est réalisée par apport de chaleur provoqué par le frottement d’un outil en rotation et mis en pression sur la pièce. Ce procédé intéresse les utilisateurs d’alliages légers car, sans passer par la fusion, il permet le soudage d’alliages à haute résistance, jusque là inutilisables en raison de leur soudabilité difficile avec les procédés traditionne...

  11. suPAR associates to glucose metabolic aberration during glucose stimulation in HIV-infected patients on HAART

    DEFF Research Database (Denmark)

    Andersen, Ove; Eugen-Olsen, Jesper; Kofoed, Kristian;

    2008-01-01

    extend these findings by investigating the association of suPAR to glucose metabolic insufficiency during an oral glucose challenge (OGTT). METHODS: In 16 HIV-infected patients with lipodystrophy and 15 HIV-infected patients without lipodystrophy, glucose tolerance, insulin sensitivity (ISI......PAR associated to important glucose metabolic aberrations in HIV-infected patients on HAART. Moreover, suPAR was stable after a glucose challenge. Future research is required to confirm these findings and explore the potential of suPAR as marker of dysmetabolism in HIV-infected patients.......OBJECTIVE: We have recently shown that the level of soluble urokinase plasminogen activator receptor (suPAR), which is associated with the immune status of HIV-infected patients undergoing highly active antiretroviral therapy (HAART), correlates with the insulin action of such patients. Here we...

  12. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  13. Pars plana vitrectomy and silicone oil tamponade for acute endophthalmitis treatment Vitrectomia pars plana e tamponamento por óleo de silicone para o tratamento de endoftalmite aguda

    Directory of Open Access Journals (Sweden)

    Rubens Camargo Siqueira

    2009-02-01

    Full Text Available PURPOSE: To evaluate the outcomes of pars plana vitrectomy and silicone oil injection for the treatment of infectious endophthalmitis. METHODS: 35 cases of endophthalmitis secondary to phacoemulsification (20 patients, trabeculectomy (8 patients, perforating trauma (2 patients, trauma (2 patients, corneal transplantation (1 patient, vitrectomy (1 patient and corneal ulceration (1 patient were retrospectively studied. Patients were separated into two groups: Group 1 (n=24: intravitreal antibiotic injection, associated with topical and oral antibiotics; Group 2 (n=11: vitrectomy with intravitreal antibiotic injection and silicone oil injection. The follow-up ranged from 1 to 48 months (mean of 16 months. RESULTS: From 24 patients in group 1, 11 patients (45.83%, had infection controlled with intravitreal antibiotic injection only; 13 patients (54.15% regressed to uncontrolled endophthalmitis, in which two patients (8.33% were submitted to evisceration and one patient (4.16% had corneal melting. The remaining 10 patients (41.66% with uncontrolled endophthalmitis were submitted to pars plana vitrectomy and silicone oil injection. Six patients (25% from Group I had retinal detachment during the first month of follow-up and also required pars plana vitrectomy and silicone oil injection. In Group 2 patients (n=11, all of them had controlled infection at the first procedure. In one case (9.09%, a severe proliferatative vitreoretinopathy induced loss of vision. CONCLUSION: These results suggest that silicone oil tamponade might be beneficial in the treatment strategy of infectious endophthalmitis.OBJETIVO: Avaliar os resultados da vitrectomia pars plana com tamponamento com óleo de silicone no tratamento de endoftalmite aguda. MÉTODOS: Trinta e cinco pacientes com endoftalmite, sendo 20 secundário à facoemulsificação, 8 por trabeculectomia, 2 por trauma perfurante, 2 por trauma, 1 por transplante de córnea, 1 por vitrectomia, e 1 por úlcera de c

  14. Caracterização de farinhas de tapioca produzidas no estado do Pará Characterization of tapioca flour obtained in Pará state, Brazil

    Directory of Open Access Journals (Sweden)

    Priscilla Andrade Silva

    2013-01-01

    Full Text Available A farinha de tapioca é um alimento produzido artesanalmente a partir da fécula de mandioca (Manihot esculenta Crantz, amplamente consumida na Região Amazônica. O objetivo deste trabalho foi caracterizar duas farinhas de tapioca produzidas no estado do Pará: uma no Baixo Amazonas e outra na Zona Bragantina. As duas farinhas apresentaram perfis granulométricos distintos e diferença significativa (P 0,05 para a maioria dos parâmetros físico-químicos e tecnológicos analisados. A farinha de tapioca proveniente do Baixo Amazonas apresentou maior umidade (10,7%, em função da maior capacidade de adsorver água, devido a sua maior área específica (menor granulometria. A microscopia óptica com luz polarizada, juntamente com as características dos dois produtos indicou a inexistência de um processo padrão utilizado na produção da farinha de tapioca.Tapioca flour is a typical food produced from cassava starch (Manihot esculenta Crantz, widely consumed in the Amazon Region. The aim of this study was to characterize two tapioca flours produced in Pará State, Brazil one in the West Region and other in Bragantina Area. Both tapioca flour presented distinct particle-size distribution and significant difference (P 0.05 for majority of the physico-chemical and technological parameters. Flour from West Region presented high moisture (10.7%, this due the greater capacity of water adsorption, attributed at its high specific area (smaller particle-size. The optical microscopy with polarized light and the technologic properties of the products did not showed a standard process for the production of tapioca flour.

  15. Perception de l'environnement urbain par les piétons : une exploration par la méthode des focus groups

    OpenAIRE

    GRANIE,MA; MONTEL,MC; Brenac, T.; COQUELET,C; PANNETIER, M; MILLOT, M; Monti, F.

    2011-01-01

    Prendre en compte l'ensemble des usagers de la voirie - et en particulier les usagers des « modes doux » - dans la conception de la voirie et des espaces publics est un enjeu majeur pour les aménageurs. Pourtant, si des connaissances existent concernant l'effet de l'environnement sur l'accidentologie des piétons, très peu de recherches, à l'heure actuelle, ont porté sur la perception de l'environnement des voies (structuration du bâti, de la végétation~) par les piétons, et son influence sur ...

  16. stratégie des déffense biochimique mise en ouevre par les olives attaquées par le ravageur

    OpenAIRE

    Meziani, Medjdoub Kenza

    2014-01-01

    Ce travail est présenté en trois parties: -La première partie est une revue bibliographique qui englobe l'olivier, sa description botanique et ses maladies ainsi que ses principaux ravageurs, dont particulièrement Bactrocera oleae, avec sa bio-écologie, et les différentes méthodes de lutte les plus pratiquées contre lui. Enfin une étude concernant les composés phénoliques et leur rôle dans la défense des plantes contre les agressions biotiques et abiotiques. -La deuxième par...

  17. Relationship between ParE gene mutation and fluoroquinolones resistance in Mycoplasma hominis%人型支原体ParE基因突变与耐氟喹诺酮类药物的关系

    Institute of Scientific and Technical Information of China (English)

    罗永慧; 段颖卿; 甘雪华; 王旭菲; 舒向荣

    2014-01-01

    目的:探讨人型支原体对氟喹诺酮类药物的耐药机制。方法自临床分离的8株耐氟喹诺酮类药物的人型支原体(Mh),对其ParE基因PCR扩增后进行测序分析,与基因库中的野生型菌株MHPG21基因序列比对,分析ParE基因突变位点与菌株耐氟喹诺酮类药物的关系。结果与野生株MHPG21对比,6株检出ParE基因所编码的氨基酸残基发生D 426→N变异。结论 Mh临床分离株对氟喹诺酮类药物的耐药可能与ParE基因所编码的氨基酸残基D 426→N变异有关。%Objective To explore the fluoroquinolones resistance meachanisms of Mycoplasma hominis (Mh). Methods A total of 8 strains of Mh with different fluoroquinolones resistance phenotype were analyzed, the ParE gene was amplified and sequenced. The sequencing results of ParE gene were compared with that in the wild type strain PG21, then analyzed the relation between ParE gene mutation and fluoroquinolones resistance. Results Compared with wild strain PG21, ParE gene in 6 strains got a D426→N mutation. Conclusion The fluoroquinolones resistance of Mh might be associate with ParE gene D426→N mutation.

  18. Etude par spectroscopie de Coulomb de points quantiques lateraux individuels et couples

    Science.gov (United States)

    Pioro-Ladriere, Michel

    Des points quantiques contenant un nombre discret et variable d'electrons sont formes dans un gaz bi-dimensionnel d'electrons a l'aide de grilles metalliques. Le transport electrique, le blocage de spin et la detection de charge sont employes comme outils spectroscopiques permettant de sonder les proprietes de ces nanostructures. Ces techniques permettent aussi de controler exactement le nombres d'electrons confines dans des points quantiques individuels et couples en utilisant un patron de grille judicieux. Une technique de refroidissement en tension est developpee afin de minimiser les effets parasites du bruit telegraphique. Ce type de bruit de charge deteriore la stabilite des nanostructures laterales par l'activation d'un minuscule courant de fuite entre les grilles et le gaz bi-dimensionnel. Un modele expliquant le role du refroidissement en tension sur le courant de fuite est presente. L'activation du courant de fuite est confirmee par detection de charge. Les effets des interactions entre les electrons pieges dans un point quantique sont ensuite etudies dans un regime ou il est possible de comparer les resulats experimentaux avec ceux obtenus par diagonalisation exacte. L'etude demontre que la phase associee au facteur de remplissage nu = 2 est instable au-dessus d'un nombre critique d'electrons. Cette instabilite est confirmee experimentalement par blocage de spin. On demontre aussi l'existence d'etats correles dans le regime des renversements de spin, associe au passage de la phase nu = 2 a nu = 1. Les etats correles sont identifies par spectroscopie en transport non lineaire. Cette caracterisation du diagramme de phase de points individuels permet de coupler deux points quantiques configures a nu = 2. Pour ce regime, la nanostructure se comporte comme un systeme a deux niveaux pouvant contenir entre un et quatre electrons de valence et ce, meme si le nombre total d'electrons est plus eleve. Les degres de liberte de charge et de spin des deux points

  19. Impacts of Light Use Efficiency and fPAR Parameterization on Gross Primary Production Modeling

    Science.gov (United States)

    Cheng, Yen-Ben; Zhang, Qingyuan; Lyapustin, Alexei I.; Wang, Yujie; Middleton, Elizabeth M.

    2014-01-01

    This study examines the impact of parameterization of two variables, light use efficiency (LUE) and the fraction of absorbed photosynthetically active radiation (fPAR or fAPAR), on gross primary production(GPP) modeling. Carbon sequestration by terrestrial plants is a key factor to a comprehensive under-standing of the carbon budget at global scale. In this context, accurate measurements and estimates of GPP will allow us to achieve improved carbon monitoring and to quantitatively assess impacts from cli-mate changes and human activities. Spaceborne remote sensing observations can provide a variety of land surface parameterizations for modeling photosynthetic activities at various spatial and temporal scales. This study utilizes a simple GPP model based on LUE concept and different land surface parameterizations to evaluate the model and monitor GPP. Two maize-soybean rotation fields in Nebraska, USA and the Bartlett Experimental Forest in New Hampshire, USA were selected for study. Tower-based eddy-covariance carbon exchange and PAR measurements were collected from the FLUXNET Synthesis Dataset. For the model parameterization, we utilized different values of LUE and the fPAR derived from various algorithms. We adapted the approach and parameters from the MODIS MOD17 Biome Properties Look-Up Table (BPLUT) to derive LUE. We also used a site-specific analytic approach with tower-based Net Ecosystem Exchange (NEE) and PAR to estimate maximum potential LUE (LUEmax) to derive LUE. For the fPAR parameter, the MODIS MOD15A2 fPAR product was used. We also utilized fAPAR chl, a parameter accounting for the fAPAR linked to the chlorophyll-containing canopy fraction. fAPAR chl was obtained by inversion of a radiative transfer model, which used the MODIS-based reflectances in bands 1-7 produced by Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm. fAPAR chl exhibited seasonal dynamics more similar with the flux tower based GPP than MOD15A2 fPAR, especially

  20. Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function

    Science.gov (United States)

    Bucci, M; Vellecco, V; Harrington, L; Brancaleone, V; Roviezzo, F; Mattace Raso, G; Ianaro, A; Lungarella, G; De Palma, R; Meli, R; Cirino, G

    2013-01-01

    Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR2 and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models. Experimental Approach Thoracic aortas were harvested from both naïve and endotoxaemic rats for in vitro studies. Arterial blood pressure was monitored in anaesthetized rats in vivo. LPS was used as a TLR4 agonist while PAR2 activating peptide (AP) was used as a PAR2 agonist. Aortas harvested from TLR4–/– mice were also used to characterize the PAR2 response. Key Results PAR2, but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PAR2AP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR2AP-induced vasorelaxation and PAR2AP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4–/– mice, the expression of PAR2 was reduced and the PAR2AP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective. Conclusions and Implications Cross-talk between PAR2 and TLR4 contributes to vascular homeostasis. PMID:22957757

  1. Etude et mise au point d'une cellule à électrodes poreuses pour la récupération d'ions métalliques en solution/study of an electrochemical cell with porous electrodes for an environmental application

    OpenAIRE

    Vande Vyver, Olivier

    2008-01-01

    Les procédés électrochimiques présentent beaucoup d’avantages dans le domaine du traitement et de la récupération de matière d’effluents industriels. Cependant, dans le cas de solutions diluées en ions métalliques, les électrodes classiques sont fortement limitées par leur efficacité ainsi que par leur taille. Dès lors, les électrodes poreuses, de par leur surface spécifique importante et de par leur structure particulière qui améliore le transport de matière et donc l’efficacité de l’électro...

  2. Relationships between high resolution RapidEye based fPAR and MODIS vegetation indices in a heterogeneous agricultural region

    Science.gov (United States)

    Fritsch, Sebastian; Machwitz, Miriam; Conrad, Christopher; Dech, Stefan

    2011-11-01

    The Moderate Imaging Spectroradiometer (MODIS) provides operational products of the Normalized Difference Vegetation Index (NDVI), the Enhanced Vegetation Index (EVI), and the fraction of photosynthetic active radiation (fPAR). FPAR can be used in productivity models, but agricultural applications depend on sub-pixel heterogeneity. Examples for heterogeneous areas are the irrigation systems of the inner Aral Sea Basin, where the 1 km fPAR product proved less suited. An alternative can be to upscale fPAR to the 250 m scale, but there are few studies evaluating this approach. In this study, the use of MODIS 250 m NDVI and EVI for this approach was investigated in an irrigation system in western Uzbekistan. The analysis was based on high resolution fPAR maps and a crop map for the growing season 2009, derived from ground measurements and multitemporal RapidEye data. The data was used to explore statistical relationships between RapidEye fPAR and MODIS NDVI/EVI with respect to spatial heterogeneity. The correlations varied between products (daily NDVI, 8-day NDVI, 16-day NDVI/EVI), with results suggesting that 8-day NDVI performed best. The analyses and the compiled fPAR maps show that, compared to 1 km MODIS fPAR, the 250 m scale is more homogeneous, allows for crop-specific analyses, and better captures the spatial patterns in the study region.

  3. ParA encoded on chromosome II of Deinococcus radiodurans binds to nucleoid and inhibits cell division in Escherichia coli

    Indian Academy of Sciences (India)

    Vijaya Kumar Charaka; Kruti P Mehta; H S Misra

    2013-09-01

    Bacterial genome segregation and cell division has been studied mostly in bacteria harbouring single circular chromosome and low-copy plasmids. Deinococcus radiodurans, a radiation-resistant bacterium, harbours multipartite genome system. Chromosome I encodes majority of the functions required for normal growth while other replicons encode mostly the proteins involved in secondary functions. Here, we report the characterization of putative P-loop ATPase (ParA2) encoded on chromosome II of D. radiodurans. Recombinant ParA2 was found to be a DNA-binding ATPase. E. coli cells expressing ParA2 showed cell division inhibition and mislocalization of FtsZ-YFP and those expressing ParA2-CFP showed multiple CFP foci formation on the nucleoid. Although, in trans expression of ParA2 failed to complement SlmA loss per se, it could induce unequal cell division in slmAminCDE double mutant. These results suggested that ParA2 is a nucleoid-binding protein, which could inhibits cell division in E. coli by affecting the correct localization of FtsZ and thereby cytokinesis. Helping slmAminCDE mutant to produce minicells, a phenotype associated with mutations in the `Min’ proteins, further indicated the possibility of ParA2 regulating cell division by bringing nucleoid compaction at the vicinity of septum growth.

  4. Developpement d'algorithmes de reconstruction statistique appliques en tomographie rayons-X assistee par ordinateur

    Science.gov (United States)

    Thibaudeau, Christian

    La tomodensitometrie (TDM) permet d'obtenir, et ce de facon non invasive, une image tridimensionnelle de l'anatomie interne d'un sujet. Elle constitue l'evolution logique de la radiographie et permet l'observation d'un volume sous differents plans (sagittal, coronal, axial ou n'importe quel autre plan). La TDM peut avantageusement completer la tomographie d'emission par positrons (TEP), un outil de predilection utilise en recherche biomedicale et pour le diagnostic du cancer. La TEP fournit une information fonctionnelle, physiologique et metabolique, permettant la localisation et la quantification de radiotraceurs a l'interieur du corps humain. Cette derniere possede une sensibilite inegalee, mais peut neanmoins souffrir d'une faible resolution spatiale et d'un manque de repere anatomique selon le radiotraceur utilise. La combinaison, ou fusion, des images TEP et TDM permet d'obtenir cette localisation anatomique de la distribution du radiotraceur. L'image TDM represente une carte de l'attenuation subie par les rayons-X lors de leur passage a travers les tissus. Elle permet donc aussi d'ameliorer la quantification de l'image TEP en offrant la possibilite de corriger pour l'attenuation. L'image TDM s'obtient par la transformation de profils d'attenuation en une image cartesienne pouvant etre interpretee par l'humain. Si la qualite de cette image est fortement influencee par les performances de l'appareil, elle depend aussi grandement de la capacite de l'algorithme de reconstruction a obtenir une representation fidele du milieu image. Les techniques de reconstruction standards, basees sur la retroprojection filtree (FBP, filtered back-projection), reposent sur un modele mathematiquement parfait de la geometrie d'acquisition. Une alternative a cette methode etalon est appelee reconstruction statistique, ou iterative. Elle permet d'obtenir de meilleurs resultats en presence de bruit ou d'une quantite limitee d'information et peut virtuellement s'adapter a toutes formes

  5. Comparative analysis of a plant pseudoautosomal region (PAR in Silene latifolia with the corresponding S. vulgaris autosome

    Directory of Open Access Journals (Sweden)

    Blavet Nicolas

    2012-06-01

    Full Text Available Abstract Background The sex chromosomes of Silene latifolia are heteromorphic as in mammals, with females being homogametic (XX and males heterogametic (XY. While recombination occurs along the entire X chromosome in females, recombination between the X and Y chromosomes in males is restricted to the pseudoautosomal region (PAR. In the few mammals so far studied, PARs are often characterized by elevated recombination and mutation rates and high GC content compared with the rest of the genome. However, PARs have not been studied in plants until now. In this paper we report the construction of a BAC library for S. latifolia and the first analysis of a > 100 kb fragment of a S. latifolia PAR that we compare to the homologous autosomal region in the closely related gynodioecious species S. vulgaris. Results Six new sex-linked genes were identified in the S. latifolia PAR, together with numerous transposable elements. The same genes were found on the S. vulgaris autosomal segment, with no enlargement of the predicted coding sequences in S. latifolia. Intergenic regions were on average 1.6 times longer in S. latifolia than in S. vulgaris, mainly as a consequence of the insertion of transposable elements. The GC content did not differ significantly between the PAR region in S. latifolia and the corresponding autosomal region in S. vulgaris. Conclusions Our results demonstrate the usefulness of the BAC library developed here for the analysis of plant sex chromosomes and indicate that the PAR in the evolutionarily young S. latifolia sex chromosomes has diverged from the corresponding autosomal region in the gynodioecious S. vulgaris mainly with respect to the insertion of transposable elements. Gene order between the PAR and autosomal region investigated is conserved, and the PAR does not have the high GC content observed in evolutionarily much older mammalian sex chromosomes.

  6. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.

    Science.gov (United States)

    Zhao, Baoyu; Gandhi, Sonu; Yuan, Cai; Luo, Zhipu; Li, Rui; Gårdsvoll, Henrik; de Lorenzi, Valentina; Sidenius, Nicolai; Huang, Mingdong; Ploug, Michael

    2015-03-27

    The urokinase-type plasminogen activator receptor (uPAR) is a multidomain glycolipid-anchored membrane protein, which facilitates extracellular matrix remodeling by focalizing plasminogen activation to cell surfaces via its high-affinity interaction with uPA. The modular assembly of its three LU (Ly6/uPAR-like) domains is inherently flexible and binding of uPA drives uPAR into its closed conformation, which presents the higher-affinity state for vitronectin thus providing an allosteric regulatory mechanism. Using a new class of epitope-mapped anti-uPAR monoclonal antibodies (mAbs), we now demonstrate that the reciprocal stabilization is indeed also possible. By surface plasmon resonance studies, we show that these mAbs and vitronectin have overlapping binding sites on uPAR and that they share Arg91 as hotspot residue in their binding interfaces. The crystal structure solved for one of these uPAR·mAb complexes at 3.0Å clearly shows that this mAb preselects the closed uPAR conformation with an empty but correctly assembled large hydrophobic binding cavity for uPA. Accordingly, these mAbs inhibit the uPAR-dependent lamellipodia formation and migration on vitronectin-coated matrices irrespective of the conformational status of uPAR and its occupancy with uPA. This is the first study to the best of our knowledge, showing that the dynamic assembly of the three LU domains in uPARwt can be driven toward the closed form by an external ligand, which is not engaging the hydrophobic uPA binding cavity. As this binding interface is also exploited by the somatomedin B domain of vitronectin, therefore, this relationship should be taken into consideration when exploring uPAR-dependent cell adhesion and migration in vitronectin-rich environments. PMID:25659907

  7. Linear study and bundle adjustment data fusion; Application to vision localization; Recherche lineaire et fusion de donnees par ajustement de faisceaux; Application a la localisation par vision

    Energy Technology Data Exchange (ETDEWEB)

    Michot, J.

    2010-12-09

    integrate this additional information directly into an extended bundle adjustment, by adding a constraint term in the weighted cost function. We evaluate three methods (based on machine learning or regularization) that dynamically select the weight associated to the constraint and show that these methods can be used in a real time multi-sensor SLAM, and validate them with different types of constraint on the orientation or on the scale. Experiments conducted on real video sequences show that this technique of constrained bundle adjustment reduces the drifts observed with the classical vision algorithms and improves the global accuracy of the positioning system. (author) [French] Les travaux presentes dans ce manuscrit concernent le domaine de la localisation et la reconstruction 3D par vision artificielle. Dans ce contexte, la trajectoire d'une camera et la structure 3D de la scene filmee sont initialement estimees par des algorithmes lineaires puis optimisees par un algorithme non-lineaire, l'ajustement de faisceaux. Cette these presente tout d'abord une technique de recherche de l'amplitude de deplacement (recherche lineaire), ou line search pour les algorithmes de minimisation iterative. La technique proposee est non iterative et peut etre rapidement implantee dans un ajustement de faisceaux traditionnel. Cette technique appelee recherche lineaire algebrique globale (G-ALS), ainsi que sa variante a deux dimensions (Two way-ALS), accelerent la convergence de l'algorithme d'ajustement de faisceaux. L'approximation de l'erreur de reprojection par une distance algebrique rend possible le calcul analytique d'une amplitude de deplacement efficace (ou de deux pour la variante Two way-ALS), par la resolution d'un polynome de degre 3 (G-ALS) ou 5 (Two way-ALS). Nos experimentations sur des donnees simulees et reelles montrent que cette amplitude, optimale en distance algebrique, est performante en distance euclidienne, et permet

  8. Utility of the plasma level of suPAR in monitoring risk of mortality during TB treatment

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian;

    2012-01-01

    Objective: To investigate whether changes in the plasma level of soluble urokinase plasminogen activator receptor (suPAR) can be used to monitor tuberculosis (TB) treatment efficacy. Design: This prospective cohort study included 278 patients diagnosed with active pulmonary TB and followed...... elevated suPAR level at time of initiation of TB treatment is associated with increased risk of mortality. Furthermore, increased suPAR levels after one month of treatment was associated with increased risk of mortality during the remaining 7-month treatment period....

  9. Cathepsin B and uPAR Knockdown Inhibits Tumor-induced Angiogenesis by Modulating VEGF Expression in Glioma

    OpenAIRE

    MALLA, RAMA RAO; Gopinath, Sreelatha; Christopher S Gondi; Alapati, Kiranmai; Dinh, Dzung H.; Gujrati, Meena; Rao, Jasti S.

    2011-01-01

    Angiogenesis, which is the process of sprouting of new blood vessels from pre-existing vessels, is vital for tumor progression. Proteolytic remodeling of extracellular matrix is a key event in vessel sprouting during angiogenesis. Urokinase plasminogen activator receptor (uPAR) and cathepsin B are both known to be overexpressed and implicated in tumor angiogenesis. In the present study, we observed that knockdown of uPAR and cathepsin B using puPAR (pU), pCathepsin B (pC), and a bicistronic c...

  10. uPAR and/or MMP-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells

    OpenAIRE

    Chetty, Chandramu; Lakka, Sajani S.; Bhoopathi, Praveen; Gondi, Christopher S.; Veeravalli, Krishna K.; Fassett, Daniel; Klopfenstein, Jeffrey D.; Dinh, Dzung H.; Gujrati, Meena; Rao, Jasti S.

    2010-01-01

    siRNA mediated transcriptional knockdown of urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9), alone or in combination, inhibits uPAR and/or MMP-9 expression and induces apoptosis in the human glioblastoma xenograft cell lines 4910 and 5310. siRNA against uPAR (pU-Si), MMP-9 (pM-Si), or both (pUM-Si) induced apoptosis and was associated with the cleavage of caspases-8, -3 and PARP. Furthermore, protein levels of the Fas receptor (APO-1/CD-95) were increase...

  11. Etude numérique de la condensation en film par convection mixte dans un canal vertical

    OpenAIRE

    Merouani, Lazhar; Zeghmati, Belkacem; Chesneau, Xavier; Belhamri, Azedine

    2007-01-01

    International audience Une étude numérique de la condensation par convection mixte laminaire d'air humide dans un canal vertical à parois non isothermes est présentée. Les transferts dans la phase liquide et dans l'air sont décrits par les équations de conservation de masse, de quantité de mouvement, d'énergie et de diffusion. Le couplage entre les équations des deux phases est assuré par la continuité des contraintes de cisaillement, des densités de flux thermique et massique à l'interfac...

  12. Traitement d'attributs inter-dépendants pour la recherche d'information par treillis

    OpenAIRE

    Messai, Nizar; Devignes, Marie-Dominique; Napoli, Amedeo; Smaïl-Tabbone, Malika

    2007-01-01

    Dans cet article nous étudions la prise en compte des relations entre attributs dans le cadre de la recherche d'information par treillis de concepts. Il s'agit en premier d'étendre l'analyse de concepts formels (FCA) pour gérer les contextes formels où il existe des relations entre les attributs et par la suite d'appliquer cette extension à la recherche d'information par treillis. Les relations entre attributs permettent de distinguer des attributs plus importants et d'autres moins importants...

  13. Sécurité et immigration : vers une gouvernementalité par l'inquiétude ?

    OpenAIRE

    Bigo, Didier

    1998-01-01

    L'immigration est lue à travers le prisme de la sécurité par certains hommes politiques, par les polices et certains services sociaux, par nombre de journalistes et une fraction de l'opinion publique. Malgré les critiques fréquentes et argumentées d'une telle perception, malgré l'existence de discours alternatifs, cette lecture continue, très largement, d'être dominante. Pourquoi ? Qu'est ce qui pousse tous ces acteurs à faire un lien entre crime, chômage, terrorisme, fanatisme et migration ?...

  14. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism

    OpenAIRE

    Bernard, Laura P.; Zhang, Huaye

    2015-01-01

    The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs), are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer’s disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippoc...

  15. Citotossicity in immune system's cells exposed in vitro to a microwave electromagnetic field in two different exposure systems operating at mobile telephones frequencies; Citotossicita' in cellule del sistema immunitario esposte in vitro al campo elettromagnetico a microonde in due diversi sistemi espositivi operanti alle frequenze della telefonia mobile

    Energy Technology Data Exchange (ETDEWEB)

    Scarcella, E.; Ardoino, L.; Galloni, P.; Mancini, S.; Marino, C. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    funzionamento di cellule macrofagiche stabilizzate e coltivate in vitro (RAW 264.7) responsabili dei meccanismi di difesa specifica e aspecifica del sistema immunitario. Sono stati, inoltre, standardizzati due diversi sistemi espositivi operanti a 900 MHz a differenti livelli di densita' di potenza (da 1 a 100 W/m{sup 2}) per garantire condizioni elettromagnetiche omogenee, idonee condizioni di incubazione delle cellule e la riproducibilita' degli esperimenti. Il lavoro di standardizzazione dei sistemi espositivi e i risultati sperimentali di questa ricerca, che hanno evidenziato differenze significative della crescita e della funzionalita' macrofagica solo al livello di densita' di potenza piu' elevato (100 W/m{sup 2}), ma recuperare dopo 48 ore dall'esposizione, risultano essere preliminari e propedeutici per una programmazione sperimentale futura atta ad approfondire una valutazione bio-tossicologica in vitro.

  16. L'interrogation du réel par le virtuel

    OpenAIRE

    Schmoll, Patrick

    2005-01-01

    A u début du roman de Greg Egan, La cité des permutants, le héros du récit, Paul Durham, se réveille dans sa chambre. Il sait qu'il a beaucoup dormi, et tout en se demandant pourquoi, il apprécie de se sentir reposé. Il tend la main paresseusement pour la placer dans le rayon de soleil qui tombe sur le coin de son lit : des poussières voltigent dans le rai de lumière qui pénètre par les rideaux disjoints, évoquant un souvenir d'enfance marqué par la même fascination pour une image semblable. ...

  17. Rabies in humans and non-human in the state of Pará, Brazilian Amazon.

    Science.gov (United States)

    Fernandes, Marcus Emanuel Barroncas; Costa, Lanna Jamile Corrêa da; Andrade, Fernanda Atanaena Gonçalves de; Silva, Lucila Pereira

    2013-01-01

    We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p<0.01), but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará, where rabies cases are proportionally five times greater than other mesoregions, suggesting that increased livestock production may influence the increase of this zoonosis. PMID:23477765

  18. Manipulation quantique de la lumière par un amplificateur non linéaire

    Science.gov (United States)

    Symul, T.; Bencheikh, K.; Levenson, J. A.

    2002-06-01

    Nous proposons un dispositif original, appelé Amplificateur Non Linéaire (ANL), permettant la génération et la manipulation d'états quantiques de la lumière. Ce dispositif permet une compression du bruit quantique de la lumière en dessous de la limite quantique standard plus efficace que celle obtenue par interactions non linéaires du second ordre ou du troisième ordre. Il permet également d'inverser les fluctuations quantiques en intensité de la lumière, et de produire des photons jumeaux ayant des corrélations quantiques plus élevées et plus robustes que ceux produits par un amplificateur paramétrique seul.

  19. Réalisation par coulage en barbotine de revêtements anti-usure

    OpenAIRE

    Sonney, Vincent; Bidaux, Jacques-Eric; Carreño-Morelli, Efraín

    2009-01-01

    Objectifs : Réalisation d’un revêtement anti-usure. Il s’agira dans un premier temps, de développer par technologie des poudres un alliage superélastique en CuAlNi. Les propriétés tribologiques sont en outre mesurées et la possibilité d’y ajouter des renforts céramiques est abordée. Dans un deuxième temps, la mise en forme par élaboration d’une barbotine à base de cuivre est étudiée. Deux utilisations de cette barbotine sont exécutées : le coulage en bande et le trempage. Résultats : Plusieur...

  20. Couplage thermomécanique lors de la soudure par ultrasons : application pour les thermoplastiques

    OpenAIRE

    Ha Minh, Duc

    2009-01-01

    Cette thèse présente un couplage thermodynamique pour une modélisation approfondie du processus de soudure par ultrasons, surtout la soudure des thermoplastiques. Il s'agit de bien connaître le mode de fonctionnement des ensembles acoustiques réalisant la soudure ainsi que le comportement des matériaux à souder. En conséquence, les propriétés de ces matériaux, surtout celles nécessaires pour la modélisation par éléments finis, sont identifiées. Les paramètres mécaniques et thermiques sont mes...

  1. Hydrodiffusion assistée par micro-ondes : nouvelle technique d'éco-extraction

    OpenAIRE

    Zill-E-Huma, Huma

    2010-01-01

    L'hydrodiffusion générée par micro-ondes est une nouvelle technique d'extraction mise au point au sein de l'Université d'Avignon et des Pays de Vaucluse. Ce procédé est une combinaison entre une technique traditionnelle et une technologie innovante. En effet, le chauffage par micro-ondes a permis d'initier et de générer le transfert de matière et de chaleur de l"intérieur des matrices végétales (oignons) vers l'extérieur et de réduire de façon considérable les temps d'extraction des antioxyda...

  2. El lenguaje no vocálico en la parálisis cerebral infantil

    OpenAIRE

    Frutos García, Elísabet

    2014-01-01

    Este Trabajo de Fin de Grado pretende abordar la comunicación y el lenguaje en un caso concreto de Parálisis Cerebral Infantil. En primer lugar, se propondrá una fundamentación teórica en la que será posible apreciar las características generales de esta discapacidad; para establecer una relación con la comunicación y el lenguaje que presentan estas personas. A partir de este estudio sobre la Parálisis Cerebral Infantil y a modo de cierre, se diseña un programa de intervención en el que s...

  3. Proyecto didáctico para alumnos con parálisis cerebral

    OpenAIRE

    Pozas León, Jessica

    2015-01-01

    En el presente Trabajo de Fin de Grado, se diseña un proyecto didáctico como medio de intervención educativa, teniendo como fin realizar actividades para trabajar con alumnos con Parálisis Cerebral, en el primer ciclo de Educación Primaria, realizando las adaptaciones más adecuadas. Se sitúa el tema empezando con una fundamentación teórica sobre el origen de la parálisis cerebral, sus características y proyectos que existen para abordar esta cuestión en educación, así como las adaptaciones...

  4. Appropriation de la stratégie par les middle managers : une étude exploratoire

    OpenAIRE

    Torset, Christophe; Tixier, Julie

    2002-01-01

    La place des middle managers dans la démarche stratégique a souvent été soulignée par la littérature stratégique (Bower, 1970 ; Burgelman 1983 ; Mintzberg 1994, Laroche 1999). Cependant, rares sont les études ayant tenté d’approfondir les caractéristiques et les déterminants de leur rôle stratégique (Floyd & Wooldridge 1990, 1992 ; Quy Nguyen 2001). Cet article cherche à évaluer le degré d’appropriation de la stratégie par les middle managers dans le contexte particulier d’une multinationale ...

  5. Rabies in humans and non-human in the state of Pará, Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Marcus Emanuel Barroncas Fernandes

    2013-04-01

    Full Text Available We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p < 0.01, but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará, where rabies cases are proportionally five times greater than other mesoregions, suggesting that increased livestock production may influence the increase of this zoonosis.

  6. Classe inversée et apprentissage par les pairs dans le supérieur

    OpenAIRE

    THIERRY, SPRIET; Mourey, Bénédicte

    2015-01-01

    International audience Nous présentons ici les réflexions en amont et en aval à l'expérimentation pédagogique que nous avons conduit cette année sur un cours de modélisation de bases de données en deuxième année de licence informatique. La mise en pratique d'une pédagogie active s'est faite au travers des principes de classe inversée et d'apprentissage par les pairs. La présentation met en évidence les gains obtenus par ces changements pédagogiques et souligne les points pratiques auxquels...

  7. L'abattage par le feu : une technique minière ancestrale

    OpenAIRE

    Ancel, Bruno; Py, Vanessa

    2008-01-01

    Depuis fort longtemps, l’homme sait que le feu a le pouvoir de fendre ou d’altérer certaines roches plutôt que d’utiliser les outils en pierre, en bois ou en corne. Les premières constatations remontent au Paléolithique pour l’extraction du silex et du quartz. Le principe du travail par le feu est simple : un bûcher de bois sec est construit au plus près de la surface de la roche. Le travail par le feu ne peut pas être conduit de la même manière selon que l’on se trouve à l’air libre ou au fo...

  8. Minimally Invasive Direct Repair of Bilateral Lumbar Spine Pars Defects in Athletes

    Directory of Open Access Journals (Sweden)

    Gabriel A. Widi

    2013-01-01

    Full Text Available Spondylolysis of the lumbar spine has traditionally been treated using a variety of techniques ranging from conservative care to fusion. Direct repair of the defect may be utilized in young adult patients without significant disc degeneration and lumbar instability. We used minimally invasive techniques to place pars interarticularis screws with the use of an intraoperative CT scanner in three young adults, including two athletes. This technique is a modification of the original procedure in 1970 by Buck, and it offers the advantage of minimal muscle dissection and optimal screw trajectory. There were no intra- or postoperative complications. The detailed operative procedure and the postoperative course along with a brief review of pars interarticularis defect treatment are discussed.

  9. Cruel and Unusual. The American Death Penalty and the Founders’ Eighth Amendment, par John Bessler

    OpenAIRE

    Grivet, Simon

    2013-01-01

    L’ordre constitutionnel étatsunien est souvent présenté avec la révérence due à un texte rédigé et promulgué dès 1787-1788 et dont la structure générale est restée intacte depuis lors. Les évolutions du texte originel de la Constitution l’ont été par le biais d’amendements au nombre de 27. Les dix premiers, adoptés ensemble lors du 1er Congrès élu de la République étatsunienne en 1789 et ratifiés par les États en 1791, ont une valeur particulière et sont depuis connus sous le nom de Bill of R...

  10. L'arbitrage et l'exportation de devises par valise

    OpenAIRE

    González, Jorge Iván; Pecha, Arcenio; Puentes, Julio

    2011-01-01

    L'article examine la signification et les implications de l'exportation de devises par valise depuis la perspective de l'arbitrage. Tout d'abord la signification économique de l'arbitrage y est abordée et il y est montré que l'exportation de devises par valise est une forme d'arbitrage. Le mouvement physique de devises a un sens économique parce que les différences entre le dollar de la rue et le taux représentatif du marché sont très importantes. Ce rapprochement met en cause d'autres lectur...

  11. Estado nutricional en niños con parálisis cerebral infantil

    Directory of Open Access Journals (Sweden)

    Drianet Castillo Peña

    2014-08-01

    Full Text Available Se realizó un estudio descriptivo, con el objetivo de caracterizar el estado nutricional de los niños que ingresaron en el Hospital Pediátrico Provincial “Mártires de las Tunas”con parálisis cerebral, en el periodo comprendido de enero a diciembre de 2012. La muestra estuvo integrada por 25 niños. La evaluación nutricional se hizo según las tablas cubanas. Se observó que predominó el sexo masculino, siendo más afectado el grupo de mayores de siete años, prevaleció la desnutrición en niños con parálisis cerebral severa. Los déficits nutricionales más frecuentes fueron la anemia, seguido de la hipoalbuminemia

  12. « Emportés par le mix »

    OpenAIRE

    Jouvenet, Morgan

    2007-01-01

    Figure centrale de l’univers des musiques électroniques, le dj est responsable du scénario indissociablement émotionnel et musical qui rassemble les auditeurs sur les pistes de danse. Les choix qui décident de la forme de son « mix » entraînent à examiner les règles et les modèles véhiculés par ce « monde de l’art » en formation, dans lequel la paternité des performances musicales se distribue de manière frappante, suivant un ensemble d’hypothèses communes sur la musique et ses effets. Le par...

  13. Disrupting the right pars opercularis with electrical stimulation frees the song: case report.

    Science.gov (United States)

    Herbet, Guillaume; Lafargue, Gilles; Almairac, Fabien; Moritz-Gasser, Sylvie; Bonnetblanc, François; Duffau, Hugues

    2015-12-01

    The authors report the first case of a strikingly unusual speech impairment evoked by intraoperative electrostimulation in a 36-year-old right-handed patient, a well-trained singer, who underwent awake surgery for a right fronto-temporo-insular low-grade glioma. Functionally disrupting the pars opercularis of the right inferior frontal gyrus led the patient to automatically switch from a speaking to a singing mode of language production. Given the central role of the right pars opercularis in the inhibitory control network, the authors propose that this finding may be interpreted as possible evidence for a competitive and independent neurocognitive subnetwork devoted to the melodically intoned articulation of words (normal language-based vs singing-based) in subjects with high expertise. From a more clinical perspective, such data may have implications for awake neurosurgery, especially to preserve the quality of life for singers. PMID:26140496

  14. Archéologie, patrimoine culturel et datation par le carbone 14

    OpenAIRE

    Daugas, Jean-Pierre

    2014-01-01

    On rappellera que les intervenants étaient conviés à démontrer la nécessité d’une nouvelle chaîne de datation par smadédiée à l’archéologie et à l’histoire de l’art ainsi qu’à illustrer l’exigence méthodologique et la rigueur scientifique à même de fonder ce programme. La difficulté à séparer la matière des communications individuelles et des débats développés par chaque table ronde, la richesse même des discussions conduites, incitent à présenter ici l’ensemble des points forts abordés dans ...

  15. K-Area and Par Pond Sewage Sludge Application Sites Groundwater Monitoring Report

    International Nuclear Information System (INIS)

    Samples from the three wells at the K-Area Sewage Sludge Application Site (KSS wells) and the three wells at the Par Pond Sewage Sludge Application Site (PSS wells) are analyzed quarterly for constituents required by South Carolina Department of Health and Environmental Control Construction Permit 13,173 and, as requested, for other constituents as part of the Savannah River Site (SRS) Groundwater Monitoring Program. Annual analyses for other constituents, primarily metals, also are required by the permit. Dichloromethane (methylene chloride) exceeded the final Primary Drinking Water Standard in a single well of the K-Area Sewage Sludge Application Site during fourth quarter 1993. Aluminum, iron, and lead, reported in excess of the SRS Flag 2 criteria at both the K-Area and Par Pond Sewage Sludge Application Sites during third quarter 1993, were not analyzed fourth quarter

  16. SURGICALLY INDUCED ASTIGMATISM AFTER 20G VS 23G PARS PLANA VITRECTOMY

    Directory of Open Access Journals (Sweden)

    Lokabhi Reddy

    2015-05-01

    Full Text Available Pars Plana Vitrectomy is done to clear the Vitreous cavity of the Eye. Trans conjunctival Sutureless Vitrectomy with 23G & 25G has become more popular over the Conventional 20G Vitrectomy in recent times. It has many advantages. Less amount of Surgically Induc ed Astigmatism is one of the Advantages with Sutureless Vitrectomy, which will have the Advantage of Early Visual rehabilitation with better Vision. An interventional comparative study was done between 20G & 23 G Pars Plana Vitrectomy in 2 Groups of 30 pat ients each to assess the amount of Post - Operative Astigmatism. The cases were followed up for 6 months to assess the long term effects. There was a significant difference in immediate Post - Operative Astigmatism. But after some time the difference is much l ess showing that the main advantage on Astigmatism with Trans conjunctival Sutureless Vitrectomy is noted mainly during the first few weeks after the Surgery.

  17. Tableau Noir de Yves Yersin (suisse, 2013) : la conviction par l’émotion

    OpenAIRE

    Cordonier, Laure

    2016-01-01

    S’agissant de la création suisse, l’édition 2013 du festival de Locarno aura notamment été marquée par le retour de Yves Yersin en tant que réalisateur. Depuis le vif succès public des Petites Fugues en 1979, Yersin a en effet moins œuvré comme cinéaste que comme enseignant dans le Département audio-visuel (DAVI) de l’ECAL. Si la présentation de son film à Locarno a été marquée par le coup d’éclat de son auteur lors de la remise d’une « mention spéciale » sur la Piazza Grande, Tableau Noir a ...

  18. Magnétométrie à hélium par pompage laser: le bilan

    Science.gov (United States)

    Gilles, H.; Hamel, J.; Monfort, Y.

    2002-06-01

    Depuis 1986, l'équipe Physique Atomique et Capteurs du CIRIL-ISMRA de Caen étudie les magnétomètres à hélium par pompage laser. On présente ici le bilan de ces travaux de recherche et les performances des deux prototypes (hélium4 et hélium3) réalisés au Laboratoire.

  19. Snake assemblages of Marajó Island, Pará state, Brazil

    OpenAIRE

    Gerson Moreira Rodrigues; Gleomar Fabiano Maschio; Ana Lúcia da Costa Prudente

    2016-01-01

    ABSTRACT We describe the diversity, natural history and structure of snake assemblages from Marajó Island, state of Pará, Brazil, after analyzing 439 specimens deposited in herpetological collections. We tested the hypothesis that snake assemblages from forest and open areas of Marajó Island are distinct with regard to their structure, composition and functional groups. To compare the snake composition of the forest and open areas of Marajó with other comparable assemblages in Brazil, Princip...

  20. Ensayo. Parálisis cerebral infantil. Estado actual y posibilidades futuras de tratamiento

    OpenAIRE

    Hernando Rafael; Victor Ayulo

    1991-01-01

    El trasplante tejido nervioso embrionario y fetal en diferentesportes l encéfalo a nivel experimental, abre nuevas posibilidades futuras su utilizacidn en humanos. La aplicación clínica reciente en el tratamiento la esquiwfrenia y enfermedad Parkinson es apenas el comienw del largo camino reconstrucci6n cerebral. Los autores creen que esta técnica puede utilizarse también en el tratamiento la parálisis cerebral infantil.