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Sample records for cellules endotheliales par

  1. Cellulitis

    Science.gov (United States)

    ... in the skin. Cellulitis is sometimes accompanied by fever, chills, and general fatigue. If the infection is left ... Cellulitis may be accompanied by swollen lymph nodes, fever, chills, and fatigue. Self-Care Guidelines If you think ...

  2. Modifications mécaniques et biologiques induites dans des cellules en culture par application locale d'une force contrôlée

    OpenAIRE

    Icard Arcizet, Delphine

    2007-01-01

    Les propriétés mécaniques des cellules adhérentes ont une importance capitale pour l'ensemble de leurs fonctions : division, migration, différenciation, etc. De plus, on sait désormais qu'elles sont très sensibles aux caractéristiques mécaniques de leur substrat, auquel elles sont ancrées par l'intermédiaire des intégrines. Ces récepteurs transmembranaires lient indirectement le cytosquelette d'actine intracellulaire aux protéines de la matrice extracellulaire.Nous avons conçu un dispositif d...

  3. M(E)CANISMES MOL(E)CULAIRES IMPLIQU(E)S DANS L'ALT(E)RATION DU PH(E)NOTYPE DES CELLULES (E)PITHELIAL(E)S TUBULAIRES PAR LES CALPA(I)NES EXTRACELLULAIRES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wen-hui; Joelle Perez; Laurent Baud

    2008-01-01

    Objectif Rechercher les mécanismes moléculaires par lesquels des calpaines extracellulaires af-fectent l'adhérence et la mobilité des cellules épithéliales HK-2 dérivées du tubule proximal humain. Méthodes Western blot pour détecter le clivage des chaines α des intégrines; dosage radioimmunologique pour mesurer l' AMP cyclique intracellulaire; fluorescence-activated cell sorting (FACS) pour tester l' apoptose cellulaire. La morpholo-gie des cellules HK-2 a été observée et photographiée. Résultats (1) L ' exposition des cellules HK-2 à la calpaine μ n'a pas entrainé de clivage des chaines o3 et αV des intégrines; (2)l' exposition des cellules HK-2 à la calpaine μ entrainait une augmentation progressive de l' accumulation intracellulaire d' AMP cyclique (P<0.05) qui était associée une résistance cellulaire à l'apoptose(P <0. 05 ) ; (3)l'addition d'un inhibiteur pharmacologique de la protéine kinase A(PKA) prévenait totalement les modifications d'adhérence et de mobilité cellulaires induites par calpaine μ Conclusion Les calpaines externalisées peuvent modifier l' adherence et la mobilité cellulaires via un mécanisme qui implique l'accumulation d' AMP cyclique et l' activation de la PKA. Par ces mécanismes, les calpaines externalisées pourraient jouer un role dans l'induction de la réparation au cours de l'insuffucance rénale aiguё.

  4. Reprogrammation épigénétique des cellules hôtes par Legionella pneumophila

    OpenAIRE

    Rolando, Monica; Rusniok, Christophe; Margueron, Raphael; Buchrieser, Carmen

    2013-01-01

    International audience Legionella pneumophila est un bacille à Gram négatif à l'origine d'une infection pulmonaire grave appelée légionellose (ou maladie du légionnaire) [11]. Les légionelles sont des bactéries vivant en milieu aquatique et affectionnant particulièrement les eaux tièdes. Ce sont des bactéries intracellulaires facultatives qui colonisent habituellement les amibes, protozoaires qui prolifèrent dans l'eau, mais elles sont également capables d'infecter l'homme par le biais d'a...

  5. Influence de revetements bioactifs sur les cellules endotheliales: Vers des protheses vasculaires non thrombotiques

    Science.gov (United States)

    Fadlallah, Hicham

    Developing vascular prostheses of small diameter to replace vessels closed by atherosclerosis remains a challenge because of the risk of thrombosis. Seeding of endothelial cells, which have antithrombogenic properties, is a promising solution, but we must create surfaces which promote their adhesion and retention to resist shear stresses created by the blood flow on the surface. This master's project aimed at investigating the effect of a plasma polymerized coating rich in primary amines (called LP), with or without elements of the extracellular matrix (Fibronectin (FN) or chondroitin sulphate (CS)) on the endothelial cells and hemocompatibility of polyethylene terephthalate (PET). The adhesion, growth and retention of human umbilical vein endothelial cells (HUVECs) on PET and LP, in the presence and absence of FN or CS, have been studied. In addition, platelet adhesion on different surfaces was evaluated by a perfusion test with whole blood, platelets being previously labeled with rhodamine. Finally a double fluorescent labeling (using Cellview Maroon to mark the HUVECs and CD61 antibody for platelets) was developed to study the retention of endothelial cells, under blood flow and verify their non thrombogenic character. The results obtained show that both the LP coating and the adsorbed FN, strongly increase both the cellular adhesion and growth on PET; however they have no additional effect when the two are combined. They also augment cellular retention to surface, but this remains incomplete. Moreover we observed that the plasma coating (LP) greatly increases the thrombogenicity of the surface, with strong platelet adhesion and activation. This thrombogenicity is extremely reduced when endothelial cells cover the surface, but cell loss under the effect of shear produced by the perfusion creates significant areas of platelet adhesion. The grafting of CS on LP also permits good HUVECs adhesion, growth and retention under shear stress on HUVEC, with no difference from the LP alone. In addition, the CS sharply decreases the platelet adhesion, which is found below the value observed for PET. The double cell labeling also showed that cells adhered on LP+CS has an anti-thrombotic phenotype and can resist blood flow. These studies suggest that a coating of CS is a promising strategy for vascular prosthesis given the combination of the good adhesion of endothelial cells and the low thrombogenicity of the underlying surface. Keywords: vascular prostheses, polymers, bioactive coating, thrombogenicity, HUVECs.

  6. Réactivation d'hépatite virale B chez un patient traité pour lymphome non hodgkinien B diffus à grandes cellules par rituximab: à propos d'un cas

    OpenAIRE

    Houssou, Bienvenu; Massi, Romaric Mahutondji; Camara, Marième; Mifdal, Hassan; Nourichafi, Nadia; Zafad, Saadia; Oukkache, Bouchra

    2015-01-01

    La réactivation du virus de l'hépatite B est secondaire à une diminution de l'immunité de l'hôte et peut être suivie d'une poussée d'hépatite aigue potentiellement mortelle. Nous rapportons le cas d'un patient D.H, 47 ans, sexe masculin, AgHBs négatif, jamais transfusé, jamais vacciné contre l'hépatite B qui avait présenté en mars 2013 un LNH B diffus à grandes cellules stade IV par moelle. Traité par 8 cures R-CHOP, il était en rémission complète clinique et paraclinique. Neuf mois après, il...

  7. Réactivation d'hépatite virale B chez un patient traité pour lymphome non hodgkinien B diffus à grandes cellules par rituximab: à propos d'un cas

    Science.gov (United States)

    Houssou, Bienvenu; Massi, Romaric Mahutondji; Camara, Marième; Mifdal, Hassan; Nourichafi, Nadia; Zafad, Saadia; Oukkache, Bouchra

    2015-01-01

    La réactivation du virus de l'hépatite B est secondaire à une diminution de l'immunité de l'hôte et peut être suivie d'une poussée d'hépatite aigue potentiellement mortelle. Nous rapportons le cas d'un patient D.H, 47 ans, sexe masculin, AgHBs négatif, jamais transfusé, jamais vacciné contre l'hépatite B qui avait présenté en mars 2013 un LNH B diffus à grandes cellules stade IV par moelle. Traité par 8 cures R-CHOP, il était en rémission complète clinique et paraclinique. Neuf mois après, il fait une rechute de son lymphome classé stade III, associée à une hépatite virale B en réplication virale (18.000 copies/mL): réactivation virale B chez porteur occulte traité avec entécavir 0.5mg par jour pendant 6 mois, l'ADN du VHB était indétectable en fin de traitement. Il avait reçu deux cures de DHAP puis deux cures R-DHAP avec une rémission complète. Lors du recueil des cellules souches en vue de l'autogreffe, l'AgHBs est à nouveau positif. Il a été greffé le 12/01/2015 et continue son traitement antiviral pour 6 mois encore. PMID:26664523

  8. Preseptal and Orbital Cellulitis

    OpenAIRE

    Emine Akçay; Gamze Dereli Can; Nurullah Çağıl

    2014-01-01

    Preseptal cellulitis (PC) is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC) is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites) or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epid...

  9. Cellules solaires photovoltaïques plastiques enjeux et perspectives

    Science.gov (United States)

    Sicot, L.; Dumarcher, V.; Raimond, P.; Rosilio, C.; Sentein, C.; Fiorini, C.

    2002-04-01

    Après avoir détaillé le fonctionnement d'une cellule photovoltaïque plastique et les paramètres photovoltaïques permettant de caractéiser son efficacité, un état de l'art des technologies de fabrication des cellules est présenté. Des moyens d'amélioration des performances des cellules photovoltaïques organiques sont ensuite illustrés par l'étude de dispositifs développés au Laboratoire Composants Organiques (LCO) du CEA Saclay.

  10. Etude de nouvelles cibles moleculaires de cancer bronchopulmonaire non a petites cellules pharmacomodulées par des substances originales naturelles et synthetiques

    OpenAIRE

    Moreau, Dimitri

    2006-01-01

    Maladie encore rare au début du 20ème siècle, le cancer du poumon est à l'origine de plus de 6 % des décès en France actuellement. Il occupe le premier rang des décès par cancer alors que la France est considérée comme un pays à risque moyen parmi les pays occidentaux. La découverte de nouveaux traitements anticancéreux toujours plus efficaces et spécifiques, est donc aujourd'hui primordiale. La validation de la capacité d'une molécule à pouvoir inhiber la prolifération cancéreuse, passe ...

  11. Cellulitis: diagnosis and management.

    Science.gov (United States)

    Bailey, Elizabeth; Kroshinsky, Daniela

    2011-01-01

    Cellulitis is an acute infection of the dermal and subcutaneous layers of the skin, often occurring after a local skin trauma. It is a common diagnosis in both inpatient and outpatient dermatology, as well as in the primary care setting. Cellulitis classically presents with erythema, swelling, warmth, and tenderness over the affected area. There are many other dermatologic diseases, which can present with similar findings, highlighting the need to consider a broad differential diagnosis. Some of the most common mimics of cellulitis include venous stasis dermatitis, contact dermatitis, deep vein thrombosis, and panniculitis. History, local characteristics of the affected area, systemic signs, laboratory tests, and, in some cases, skin biopsy can be helpful in confirming the correct diagnosis. Most patients can be treated as an outpatient with oral antibiotics, with dicloxacillin or cephalexin being the oral therapy of choice when methicillin-resistant Staphylococcus aureus is not a concern. PMID:21410612

  12. Preseptal and orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Emine Akçay

    2014-09-01

    Full Text Available Preseptal cellulitis (PC is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, Haempphilus influenzae, Moraxella catarrhalis and S. pyogenes. The method for the diagnosis of OS and PS is computed tomography. Using effective antibiotics is a mainstay for the treatment of PC and OC. There is an agreement that surgical drainage should be performed in cases of complete ophthalmoplegia or significant visual impairment or large abscesses formation. This infections are also at a greater risk of acute visual loss, cavernous sinus thrombosis, meningitis, cerebritis, endophthalmitis, and brain abscess in children. Early diagnosis and appropriate treatment are crucial to control the infection. Diagnosis, treatment, management and complications of PC and OC are summarized in this manuscript. J MicrobiolInfect Dis 2014; 4(3: 123-127

  13. Odontogenic Facial Cellulitis

    Directory of Open Access Journals (Sweden)

    Yordany Boza Mejias

    2012-11-01

    Full Text Available Background: odontogenic facial cellulitis is an acute inflammatory process manifested in very different ways, with a variable scale in clinical presentation ranging from harmless well defined processes, to diffuse and progressive that may develop complications leading the patient to a critical condition, even risking their lives. Objective: To characterize the behavior of odontogenic facial cellulitis. Methods: A descriptive case series study was conducted at the dental clinic of Aguada de Pasajeros, Cienfuegos, from September 2010 to March 2011. It included 56 patients who met the inclusion criteria. Variables analyzed included: sex, age, teeth and regions affected, causes of cellulite and prescribed treatment. Results: no sex predilection was observed, lower molars and submandibular anatomical region were the most affected (50% and 30 4% respectively being tooth decay the main cause for this condition (51, 7%. The opening access was not performed to all the patients in the emergency service. The causal tooth extraction was not commonly done early, according to the prescribed antibiotic group. Thermotherapy with warm fomentation and saline mouthwash was the most prescribed and the most widely used group of antibiotics was the penicillin. Conclusions: dental caries were the major cause of odontogenic cellulite. There are still difficulties with the implementation of opening access.

  14. Understanding pediatric bacterial preseptal and orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Gonzalez Mithra

    2010-01-01

    Full Text Available Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Patients are usually treated with broad spectrum antibiotics and surgery when indicated.

  15. Evaluation of Pediatric Patients with Orbital and Preseptal Cellulitis

    Directory of Open Access Journals (Sweden)

    Eren Cagan

    2015-06-01

    Conclusion: Preseptal cellulitis is more frequently observed than orbital cellulitis. The most important predisposing factor for orbital cellulitis is sinusitis. Patients with preseptal cellulitis suspected clinically may be diagnosed with orbital cellulitis radiologically. As a result radiological imaging of preseptal cellulitis patients should be considered. [Cukurova Med J 2015; 40(2.000: 267-274

  16. ETUDE D’UNE CELLULE SOLAIRE PHOTOVOLTAIQUE A HETEROJONCTION n CdS /pCdTe

    OpenAIRE

    BENZEGHADI, Halima; OUDJAMAA, NABAWIYA

    2014-01-01

    Dans les cellules solaires à hétérojonction, le champ électrique créé par la gradient de la zone de charge d’espace permet de réduire le processus de la recombinaison superficielle. Ceci augmente la conductibilité et les performances des cellules solaires. Le tellurure de cadmium possède des propriétés cristallographiques et électriques très intéressantes le rendant ainsi très recherché pour la fabrication de cellules solaires. Dans cet ordre d’idées nous nous ...

  17. Etude d'une cellule photovoltaïque à jonction liquide : la cellule GaAs-n/(Se2-/Sen2-)/Pt

    OpenAIRE

    Bourrasse, A.; Cachet, H.; Horowitz, G.; Le Crom, S.

    1982-01-01

    Une étude de la cellule GaAs-n/(Se2- /Sen2- )/Pt, où l'électrode de GaAs est protégée contre la photo-décomposition par le couple redox séléniure/polyséléniure, est présentée. Un rendement énergétique de 11 % sous éclairement par une lampe à arc xénon a été atteint. La cellule a pu fonctionner pendant huit jours sous illumination solaire sans que l'on observe de baisse de ses performances. La faible décomposition de la photoanode est attribuée à la dégradation de l'électrolyte, provoquée par ...

  18. Expression de P53 dans les tumeurs à cellules géantes osseuses

    OpenAIRE

    Trottet, Cécile

    2001-01-01

    Le gène de la p53 est considéré comme un gène suppresseur de tumeur. Nous avons étudié son expression dans les tumeurs à cellules géantes osseuses (TCG) pour rechercher s'il pouvait être considéré comme un marqueur prédictif de l'évolution dans les TCG. La protéine p53 a été étudiée dans 33 cas de tumeurs à cellules géantes osseuses par immunohistochimie pour analyser son expression et par Single Strand Conformation Polymorphism (SSCP) pour rechercher la présence de mutations dans les tumeurs...

  19. Expression de P53 dans les tumeurs à cellules géantes osseuses

    OpenAIRE

    Trottet, Cécile; Borisch, Bettina; Bonjour, Jean-Philippe

    2005-01-01

    Le gène de la p53 est considéré comme un gène suppresseur de tumeur. Nous avons étudié son expression dans les tumeurs à cellules géantes osseuses (TCG) pour rechercher s'il pouvait être considéré comme un marqueur prédictif de l'évolution dans les TCG. La protéine p53 a été étudiée dans 33 cas de tumeurs à cellules géantes osseuses par immunohistochimie pour analyser son expression et par Single Strand Conformation Polymorphism (SSCP) pour rechercher la présence de mutations dans les tumeurs...

  20. Cellulitis

    Science.gov (United States)

    The health care provider will perform a physical exam. This may reveal: Redness, warmth, and swelling of the skin Possible drainage, if there is a buildup of pus ( abscess ) with the skin infection Swollen glands (lymph nodes) ...

  1. Cellulitis

    Science.gov (United States)

    ... Eye Drops Lazy eye (defined) Pink eye (defined) Retinopathy of Prematurity Strabismus Stye (defined) Vision Screening Vision Screening Recommendations ... Eye Drops Lazy eye (defined) Pink eye (defined) Retinopathy of Prematurity Strabismus Stye (defined) Vision Screening Vision Screening Recommendations ...

  2. Cellules photo-électrochimiques à électrodes semiconductrices pour la conversion et le stockage de l'énergie solaire

    OpenAIRE

    Horowitz, G.; Bourrasse, A.

    1980-01-01

    Discipline récente, la conversion photo-électrochimique (PEC) de l'énergie solaire a connu ces dernières années un important effort de recherche. Les cellules PEC se caractérisent par la présence d'électrodes semiconductrices. L'étude théorique de leur fonctionnement, et en particulier de la stabilité des électrodes semiconductrices, conduit à distinguer deux types de cellules : les cellules autorégénérées, fournissant de l'énergie électrique, et les cellules de stockage, permettant la généra...

  3. Assoziationen zwischen endothelialer Dysfunktion und Adhäsionsmolekülen, sowie molekularen Markern der Entzündung bei Nachkommen von Typ-2-Diabetikern

    OpenAIRE

    Beckmann, Patrick

    2005-01-01

    Ziele: Die Atherosklerose korreliert eng mit dem Diabetes mellitus Typ 2. Als Grundlage vieler kardiovaskulärer Erkrankungen wird sie heute als eine chronische subklinische Entzündungsreaktion gesehen. Ein früher Marker in der Entwicklung der Atherosklerose ist die mittels hochauflösendem Ultraschall zu messende endotheliale Dysfunktion. Es wäre durchaus nützlich, einfache Verfahren zu finden, die eine Risikoabschätzung bezüglich der Diabetes- bzw. Atheroskleroseentwicklung ermöglichen. Da...

  4. Cellulitis Due to Salmonella infantis.

    Directory of Open Access Journals (Sweden)

    Satish R Patil

    2013-01-01

    Full Text Available Bacteria of the genus Salmonella are highly adapted for the growth in both humans and animals and cause a wide spectrum of disease. The growth of Serotypes S. typhi and S. paratyphi is restricted to human hosts, in whom these organisms cause enteric (typhoid fever. The remaining Serotypes (non typhoidal Salmonella or NTS can colonize the gastrointestinal tracts of the broad range of animals, including mammals, reptiles, birds and insects. The usual clinical presentation of non-typhoidal salmonellae (NTS infection is self limited gastroenteritis; however bacteremia and focal extra intestinal infection may occur. However salmonella localization to the skin presenting as cutaneous ulceration is regarded as a rare event. Rates of morbidity and mortality associated with NTS are highest among the elderly, infants, and immunocompromised individuals, including those with hemoglobinopathies, HIV infection, or infections that cause blockade of the reticuloendothelial system. We isolated S.infantis in 50 years old man with left leg cellulitis. The serotype was confirmed at Central Research Institute, Kasauli.

  5. Contribution à l’amélioration des performances des cellules solaires à base de InGaN.

    OpenAIRE

    Mostefaoui, Mohamed Amine

    2015-01-01

    L’énergie photovoltaïque convertit directement l’énergie Lumineuse en énergie électrique par des cellules solaires. Selon les besoins, l’électricité produite peut être utilisée pour l’alimentation d’un site isole ou revendue en tout ou partie au réseau de Distribution. Ce travail consiste à étudier et simuler une cellule solaire à base du matériau InGaN. Après avoir rappelé les caractéristiques d’une cellule solaire, l’influence des différents paramètres sur les caractéristi...

  6. Bullous leukemia cutis mimicking facial cellulitis*

    Science.gov (United States)

    Caldato, Luciana de Sales; Britto, Juliana de Sousa; Niero-Melo, Ligia; Miot, Hélio Amante

    2016-01-01

    Bullous leukemia cutis is an uncommon clinical manifestation of cutaneous infiltration by leukemic cells, from B-cell chronic lymphocytic leukemia. We present the case of a 67-year-old, female, chronic lymphocytic leukemia patient. She was taking chlorambucil and developed facial edema with erythema and warmth, misjudged as facial cellulitis. Two days later, she developed bullous lesions in the arms, legs, neck and face. The histopathology of facial and bullous lesions confirmed leukemia cutis. All lesions disappeared following the administration of rituximab combined with cycles of fludarabine and cyclophosphamide. Although soft tissue infections are common complications in patients undergoing chemotherapy, leukemia cutis can also resemble cellulitis. PMID:27192532

  7. Celulitis por citomegalovirus Cytomegalovirus cellulitis

    Directory of Open Access Journals (Sweden)

    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.Cutaneous lesions in CMV infection are rare, often a late manifestation of systemic infection, and usually herald a fatal course. A 70 year-old woman received a kidney transplantation one month before consulting and immunosuppressive therapy that included cyclosporine A and methylprednisone. She complained of fever, local pain in her right leg, and an erythematous and swelling plaque. She was treated with intravenous antibiotics without improvement. A skin biopsy was performed and the tissue obtained was sent for bacterial and fungal cultures as well as for histological examination. Cultures were negative. The biopsy showed CMV cytopathic changes. Immunoperoxidase staining was positive for CMV and polymerase chain reaction (PCR testing revealed CMV DNA. She was treated with ganciclovir with resolution of the lesion. CMV cellulitis is a rare cutaneous manifestation

  8. Il controllo epigenetico di geni oncosoppressori nelle cellule staminali neuronali normali e di medulloblastoma

    OpenAIRE

    Begalli, Federica

    2013-01-01

    Le cellule staminali cerebellari normali fanno parte della grande famiglia delle cellule staminali somatiche, deputate a sostituire le cellule che muoiono per omeostasi fisiologica del tessuto o per un danno. Tali cellule mantengono alcune delle caratteristiche versatili delle cellule staminali embrionali. In particolare sono dotate della capacità di auto-rinnovamento indefinito e di multipotenza, difatti sono in grado di differenziare in più linee cellulari. Le cellule staminali neuronali ...

  9. Facial cellulitis revealing choreo-acanthocytosis: a case report

    OpenAIRE

    Samia, Younes; Yosra, Cherif; Foued, Bellazreg; Mouna, Aissi; Olfa, Berriche; Jihed, Souissi; Hammadi, Braham; Mahbouba, Frih-Ayed; Amel, Letaief; Habib, Sfar Mohamed

    2014-01-01

    We report a 62 year-old-man with facial cellulitis revealing choreo-acanthocytosis (ChAc). He showed chorea that started 20 years ago. The orofacial dyskinisia with tongue and cheek biting resulted in facial cellulitis. The peripheral blood smear revealed acanthocytosis of 25%. The overall of chorea, orofacial dyskinetic disorder, peripheral neuropathy, disturbed behavior, acanthocytosis and the atrophy of caudate nuclei was suggestive of a diagnosis of ChAc. To our knowledge no similar cases...

  10. Sweet's syndrome associated with cellulitis - a challenging diagnosis*

    OpenAIRE

    Resende, C; Santos, R.; T. Pereira; Brito, C.

    2016-01-01

    Sweet's syndrome is a neutrophilic dermatosis with worldwide distribution that has been associated with inflammatory autoimmune diseases, infections, malignancies, drugs, and pregnancy. The disease is idiopathic in up to 50% of patients. A 64-year-old woman, diagnosed with right limb cellulitis (4 days of evolution), was seen at our department, due to persistent cellulitis and progressive appearance of painful nodules and plaques in both shins and the right forearm (2 days of evolution). Take...

  11. Serratia marcescens: an unusual pathogen associated with snakebite cellulitis.

    Science.gov (United States)

    Subramani, Parimala; Narasimhamurthy, Gokul Bindiganavile; Ashokan, Bhaskaran; Madappa, Beena Prasavangada

    2013-02-15

    This study reports a case of Serratia marcescens cellulitis following a snakebite in a 50-year-old woman. The bite was on the dorsum of the right hand with symptoms of envenomation. She developed swelling and cellulitis with tissue necrosis. Wound debridement was performed.  Pus and tissue biopsy cultures yielded Serratia marcescens sensitive to fluoroquinolones, aminoglycosides, third-generation cephalosporins and carbapenems. The patient responded to anti-snake venom (ASV) therapy, ciprofloxacin, local wound management and recovered uneventfully.

  12. Study of the cetuximab-ionizing radiation association on a model of in vitro endothelial cells; Etude de l'association cetuximab-radiations ionisantes sur un modele de cellules endotheliales in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Vautravers-Dewas, C.; Rebucci, M.; Lansiaux, A. [Centre Oscar-Lambret, Inserm U837, Lab. de Pharmacologie Antitumorale, 59 - Lille (France); Peixoto, P. [Inserm U837, 59 - Lille (France); Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2009-10-15

    These data support the existence of functional signalling tracks downstream epidermal growth factor receptor (E.G.F.R.) in endothelial cells. But our in vitro model, in two dimensional calculations, did not allow to show a radiosensitivity by cetuximab. The study of functional consequences of the association cetuximab-irradiation treatment will be relevant in an in vitro three dimensional model and on xenografts. (N.C.)

  13. Effet du stress oxydant sur les cavéoles dans les cellules musculaires squelettiques

    OpenAIRE

    Mougeolle, Alexis

    2014-01-01

    La sarcopénie est une maladie dégénérative liée à l’âge qui se caractérise par une perte progressive et involontaire de la masse et de la force musculaire. Elle s’accompagne d’une atteinte de la régénération musculaire et d’une accumulation des espèces réactives de l’oxygène. Les cavéoles sont des invaginations de la membrane plasmique. Dans le muscle, elles jouent un rôle dans la différenciation des cellules satellites et dans le maintien de l’unité contractile dans le muscle différencié. Ce...

  14. Synthèse et caractérisation de cellules pour pile à combustible de type IT-SOFC utilisée en tant que système APU dans les transports

    OpenAIRE

    Sivasankaran, Visweshwar,

    2014-01-01

    La fabrication de cellules de piles à combustible IT-SOFC de large dimension par un nouveau procédé simple et peu coûteux est présentée dans ce manuscrit. L’optimisation de ce nouveau procédé en regard de l’utilisation d’agents de porosité, d’épaisseur de couches et de température de frittage a été réalisée. Les résultats des tests électrochimiques sur des cellules de surface active 10 cm2 réalisés dans le dispositif Fiaxell semi-ouvert ont été détaillés pour différentes cellules. Des tests d...

  15. Epidemiological characteristics of lower extremity cellulitis after a typhoon flood.

    Directory of Open Access Journals (Sweden)

    Pei-Chen Lin

    Full Text Available OBJECTIVE: The flood after a typhoon may lead to increase in patients with cellulitis of lower limbs. However, the microbiological features of these cases are rarely reported. We conducted a study of patients with lower extremity cellulitis after a typhoon followed in southern Taiwan to study the risk factors of cellulitis and the bacteriological features of the patients. METHODS: We reviewed all the medical records of cellulitis at emergency departments of two teaching hospitals in southern Taiwan 30 days before and after the landing of Typhoon Morakot and collected data on the demographic and bacteriological characteristics. In addition, we evaluated the relationship between the daily number of patients and the rainfall in the Tainan area. RESULTS: The number of cellulitis patients increased from 183 to 344 during the 30-day period after the typhoon. The number peaked in the third and fourth days and lasted for 3 weeks. The proportion of patients with water immersion of the affected limb was higher after the typhoon (6% vs. 37%, odds ratio [OR]: 9.0, 95% Confidence interval [CI]: 4.7-17.2. We found cultures from the infected limbs with immersion had more polymicrobial (73% vs. 26%, OR: 7.8, 95% CI: 3.2-19.2 and Gram-negative bacilli infection (86% vs. 34%, OR: 11.8, 95% CI: 4.1-34.5. CONCLUSIONS: Flood arose from Typhoon Morakot caused increases in cellulitis patients, which lasted for 3 weeks. Antibiotic treatment that were effective to both Gram-positive cocci and Gram-negative bacilli are recommended for patients with limbs emerged in the water.

  16. Outcome assessment in cellulitis clinical trials: is telephone follow up sufficient?

    Science.gov (United States)

    Nambudiri, V E; Dwyer, R C; Camargo, C A; Kupper, T S; Pallin, D J

    2015-07-01

    The US Food and Drug Administration has scrutinized clinical trial methodology in cellulitis, partly because the definition and timing of cure are debatable. We analysed the validity of telephone self-report as a proxy for in-person follow up in a cellulitis treatment trial comparing cephalexin alone with cephalexin-plus-trimethoprim/sulfamethoxazole. Our results demonstrate poor agreement between these two methods of outcome determination and have implications for future cellulitis clinical trial design and clinical management. PMID:25882364

  17. Group a streptococcal cellulitis in the early puerperium

    OpenAIRE

    Nikolić Branka; Mitrović Ana; Dragojević-Dikić Svetlana; Rakić Snežana; Cakić Zlatica; Saranović Milena; Sikimić Milan

    2011-01-01

    Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS) are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerp...

  18. Posttraumatic Fat Necrosis Presented as Cellulitis of the Leg

    Directory of Open Access Journals (Sweden)

    Einat Haikin Herzberger

    2012-01-01

    Full Text Available Cellulitis, a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin, is a common lesion in children, usually responsive to systemic antibiotic therapy. However, an unusual course of healing or some nontypical features should call the treating physician to consider and investigate for other diagnoses that might prevent unnecessary treatment and alleviate parental stress. We present a case of posttraumatic fat necrosis, demonstrating some pitfalls in the process of diagnosis.

  19. Acetaminophen-induced cellulitis-like fixed drug eruption

    OpenAIRE

    Neila Fathallah; Chaker Ben Salem; Raoudha Slim; Lobna Boussofara; Najet Ghariani; Kamel Bouraoui

    2011-01-01

    Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption ...

  20. Etude théorique des cellules solaires PV organiques: structure réseau interpénétré polymère conjugué-fullerène et cellules Graetzel

    OpenAIRE

    Zakaria, BOUZID

    2014-01-01

    Le photovoltaïque est aujourd'hui une technologie d'énergie renouvelable en plein essor. La croissance du marché a été comprise entre 15% et 20% durant la dernière décennie. Malgré le développement des matériaux et des méthodes de fabrication fortement soutenus par la croissance de l'industrie des semi-conducteurs, le coût des cellules solaires est resté élevé. Cependant, de nouveaux matériaux photovoltaïques ont été développés durant les dernières années, cela pourrait bien ouvri...

  1. Capacità immunomodulatrice delle cellule staminali mesenchimali di cavallo da midollo osseo: risultati preliminari su cellule mononucleate

    OpenAIRE

    Riccò, Sarah

    2010-01-01

    Negli ultimi anni è emerso l’uso delle MSCs (multipotent mesenchymal stromal cells) nella medicina rigenerativa soprattutto per la terapia dei tendini e dei legamenti nel cavallo. La terapia con MSCS allogeniche potrebbe essere un utile strumento quando non è possibile isolare e amplificare le cellule del paziente. L’attività immunomodulatrice delle MSCS è stata studiata in diverse specie animali e nell’uomo ma nessun dato è stato riportato nel cavallo. In questo lavoro abbiamo riportato la c...

  2. Modelisation par elements finis du muscle strie

    Science.gov (United States)

    Leonard, Mathieu

    Ce present projet de recherche a permis. de creer un modele par elements finis du muscle strie humain dans le but d'etudier les mecanismes engendrant les lesions musculaires traumatiques. Ce modele constitue une plate-forme numerique capable de discerner l'influence des proprietes mecaniques des fascias et de la cellule musculaire sur le comportement dynamique du muscle lors d'une contraction excentrique, notamment le module de Young et le module de cisaillement de la couche de tissu conjonctif, l'orientation des fibres de collagene de cette membrane et le coefficient de poisson du muscle. La caracterisation experimentale in vitro de ces parametres pour des vitesses de deformation elevees a partir de muscles stries humains actifs est essentielle pour l'etude de lesions musculaires traumatiques. Le modele numerique developpe est capable de modeliser la contraction musculaire comme une transition de phase de la cellule musculaire par un changement de raideur et de volume a l'aide des lois de comportement de materiau predefinies dans le logiciel LS-DYNA (v971, Livermore Software Technology Corporation, Livermore, CA, USA). Le present projet de recherche introduit donc un phenomene physiologique qui pourrait expliquer des blessures musculaires courantes (crampes, courbatures, claquages, etc.), mais aussi des maladies ou desordres touchant le tissu conjonctif comme les collagenoses et la dystrophie musculaire. La predominance de blessures musculaires lors de contractions excentriques est egalement exposee. Le modele developpe dans ce projet de recherche met ainsi a l'avant-scene le concept de transition de phase ouvrant la porte au developpement de nouvelles technologies pour l'activation musculaire chez les personnes atteintes de paraplegie ou de muscles artificiels compacts pour l'elaboration de protheses ou d'exosquelettes. Mots-cles Muscle strie, lesion musculaire, fascia, contraction excentrique, modele par elements finis, transition de phase

  3. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  4. Clinical and microbiologic features of dacryocystitis-related orbital cellulitis.

    Science.gov (United States)

    Wladis, Edward J; Shinder, Roman; LeFebvre, Daniel R; Sokol, Jason A; Boyce, Michelle

    2016-10-01

    Dacryocystitis-related orbital cellulitis is a relatively rare condition, and large case series of this clinical entity have been reported. This study was undertaken to identify a larger cohort of patients with this ailment, with the intent of defining its clinical and microbiologic features. Case logs from four institutions were reviewed to identify patients that suffered from dacryocystitis-related orbital cellulitis. A retrospective chart review was then performed to identify clinical features, management strategies, microbiologic features, and outcomes. A dedicated statistical software package was utilized to identify correlations between these variables. 13 patients (7 females, 6 males; mean age = 57.2 years, range = 7-89 years) were identified. One patient carried a diagnosis of immunosuppressive disease. All patients underwent emergent surgical drainage and received intravenous antibiotics. Primary acquired nasolacrimal duct obstruction was found to be the underlying etiology in nine cases (69.2%), whereas four patients suffered from specific causes of their obstructions. An average of 1.07 organisms/patient (standard deviation = 0.49 organisms/patient) were recovered from microbiologic cultures, and Gram-positive bacteria represented the majority of cultured organisms. All patients experienced either stable or improved vision upon discharge. The relationships between a specific etiology and the possibility of vision loss or the number of organisms cultured, between the number of organisms cultured and vision loss, and immunosuppression and vision loss or the number of organisms cultured were all not statistically significant (p > 0.05). Dacryocystitis-related orbital cellulitis most commonly occurs in adult patients who do not carry immunosuppressive diagnoses and suffer from primary obstructions. Multiple microbiologic species may cause this problem, although Gram-positive organisms are most common. With appropriate management, stable or improved vision

  5. Antimicrobial resistance of bacterial strains isolated from avian cellulitis

    Directory of Open Access Journals (Sweden)

    MM Santos

    2014-03-01

    Full Text Available Avian cellulitis is an inflammatory process in the subcutaneous tissue, mainly located in the abdomen and thighs. This problem is commonly observed in poultry at slaughter and it is considered one of the major causes of condemnation of carcasses in Brazil. The aim of this study was to perform the microbial isolation of lesions of avian cellulitis from a processing plant located in the State of Goiás in order to analyze antimicrobial resistance by antibiogram test and to detect resistance genes by polymerase chain reaction. A total of 25 samples of avian cellulitis lesions were analyzed, from which 30 bacterial strains were isolated. There were eleven (44% strains of Escherichia coli, nine (36% strains of Staphylococcus epidermidis, seven (28% strains of Proteus mirabilis and three (12% strains of Manheimiahaemolytica. The antibiogram test showed that all strains were resistant to at least one antimicrobial. The gene of antimicrobial resistance tetB was detected in E. coli, S. epidermidis and P. mirabilis strains, and was the most frequently observed gene. The gene of antimicrobial resistance Sul1 was detected in all bacterial species, while tetA was found in E. coli and S. epidermidis strains, SHV in E. coli strains, S. epidermidis and P. mirabilis,and cat1 in one P. mirabilis strain. The results suggest a potential public health hazard due to the ability of these microorganisms to transmit antimicrobial resistancegenes to other microorganisms present in the intestinal tract of humans and animals, which may affect clinical-medical usage of these drugs.

  6. Cryptococcal cellulitis on the shin of an immunosuppressed patient.

    Science.gov (United States)

    Zhu, Tian Hao; Rodriguez, Paola G; Behan, James W; Declerck, Brittney; Kim, Gene H

    2016-01-01

    Cryptococcus neoformans is a common fungus found throughout the environment that causes opportunistic disease in immunocompromised individuals. Infection of humans with C neoformans usually manifests as lung disease through inhalation of spores or meningoencephalitis by involvement of the central nervous system. Rarely, dissemination in the form of cutaneous lesions can occur in individuals with long term immunosuppression. We present a patient with C. neoformans manifesting as cellulitis with focal segmental glomerulosclerosis treated with corticosteroids. Because of the mortality associated with disseminated cryptococcosis, early identification, especially of atypical cutaneous presentations is critical from a dermatological perspective. PMID:27617599

  7. Complete Vision Loss following Orbital Cellulitis Secondary to Acute Dacryocystitis

    Science.gov (United States)

    Pfeiffer, Margaret L.; Hacopian, Alexander; Merritt, Helen

    2016-01-01

    We present a case of a 50-year-old woman with acute dacryocystitis that was complicated by posterior rupture of the lacrimal sac causing an orbital cellulitis with subsequent visual acuity of no light perception. Upon presentation, she was immediately started on broad-spectrum antibiotics and underwent surgical incision and drainage of the lacrimal sac abscess but never regained vision. There are 4 cases in the literature of permanent severe vision loss from acute dacryocystitis. Prompt diagnosis and close monitoring of acute dacryocystitis are therefore essential to prevent extension into the orbit and possible optic nerve compromise.

  8. Acute neck cellulitis and mediastinitis complicating a continuous interscalene block.

    Science.gov (United States)

    Capdevila, Xavier; Jaber, Samir; Pesonen, Pertti; Borgeat, Alain; Eledjam, Jean-Jacques

    2008-10-01

    We report a case of acute neck cellulitis and mediastinitis complicating a continuous interscalene brachial plexus block. A 61-yr-old man was scheduled for an elective arthroscopic right shoulder rotator cuff repair. A continuous interscalene block was done preoperatively and 20 mL of 0.5% bupivacaine and 20 mL of 2% mepivacaine were injected through the catheter. Postoperative analgesia was provided by a continuous infusion of bupivacaine, 0.25% at 5 mL/h for 39 h using a 240-mL elastomeric disposable pump. The day after surgery, the patient complained of neck pain. The analgesic block was not fully effective. He was discharged home. Three days later, the patient was readmitted with neck edema and erythema, fever and fatigue. Neck ultrasonography and computed tomographic scan revealed an abscess of the interscalene and sternocleidomastiod muscles and cellulitis, as well as acute mediastinitis. Two blood cultures and surgical samples were positive for Staphylococcus aureus. The infection was treated with surgery, the site was surgically debrided, and a 2-mo course of vancomycin, imipenem, and oxacilline. The technique of drawing local anesthetic from the bottle and filling the elastomeric pump was the most likely cause of infection. This case emphasizes the importance of strict aseptic conditions during puncture, catheter insertion, and management of the local anesthetic infusate. PMID:18806062

  9. Caracterisations des cellules photovoltaiques a base des ôlymeres conducteurs

    OpenAIRE

    ANSRI, Amel

    2012-01-01

    Ce travail de recherche est porté sur la caractérisation des cellules photovoltaïques organiques. Le développement de ces cellules constitue un grand enjeu de la filière électronique organique. Ces cellules sont aussi prometteuses pour la production d'énergie à bas coût. Elles peuvent être fabriquées sur substrat souple, ce qui leur permettra une intégration facile dans les appareils nomades comme les téléphones portables et les ordinateurs portables. Dans ce cadre et dans le but ...

  10. Prospective study on sociodynamics of cellulitis in general surgical unit

    Directory of Open Access Journals (Sweden)

    Didde Sundara Chakravarthy

    2015-05-01

    Results: The median age of the participants was 62.5 years. The following risk factors were strongly and independently associated with cellulitis and outcome of the patient; illiteracy (OR, 4; P value 0.010, age above 50 years (OR, 0.110; P value 0.000, residing in rural areas (OR, 4.008; P value 0.006, low socioeconomic status (OR, 0.241; P value 0.030 and associated co-morbid conditions (OR, 0.390; P value, 0.032. Conclusion: Patients usually presented in the late stage of disease because of illiteracy, ignorance and poor knowledge. Patients should be educated to routinely inspect their feet, and the importance of appropriate footwear should be emphasized. Patients who are actively involved in their care can improve their quality of life and have a better outcome. [Int J Res Med Sci 2015; 3(5.000: 1052-1055

  11. Chemical Cellulitis due to Peanut Oil Administration. A Case Report

    Directory of Open Access Journals (Sweden)

    Julio César Turiño Muro

    2014-03-01

    Full Text Available Chemical cellulitis is the reaction of the integuments in response to the administration of toxic substances, leading to an acute inflammatory reaction that develops into an abscess or necrosis. This disease is not frequently treated in the Department of Orthopedics and Traumatology of the Joaquin Albarrán Clinical-Surgical Hospital. We present the case of a patient who attended our institution because of increased volume in both upper limbs at the biceps and triceps areas, and marked skin necrosis accompanied by lesions of axillary adenopathy, one as an abscess. Antibiotics were prescribed prior to the completion of cultures, antibiogram and dressing under anesthesia, at present the lesions are in the healing phase.

  12. Acetaminophen-induced cellulitis-like fixed drug eruption

    Directory of Open Access Journals (Sweden)

    Neila Fathallah

    2011-01-01

    Full Text Available Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption induced by acetaminophen was considered especially with a reported history of a previous milder reaction occurring in the same site. Acetaminophen was withdrawn and the rash improved significantly. According to the Naranjo probability scale, the eruption experienced by the patient was probably due to acetaminophen. Clinicians should be aware of the ability of acetaminophen to induce fixed drug eruption that may clinically take several aspects and may be misdiagnosed.

  13. Toxic scarlet fever complicating cellulitis: early clinical diagnosis is crucial to prevent a fatal outcome.

    Science.gov (United States)

    Lau, S K; Woo, P C; Yuen, K Y

    2004-04-01

    We describe a case of toxic scarlet fever in a healthy adult with streptococcal cellulitis of the right elbow as a result of skin abrasion. The clinical picture mimicked that of drug eruption after treatment of cellulitis with antibiotics. Among the five cases of scarlet fever complicating cellulitis, including the present one, reported in the English literature, four had severe systemic complications and two died. As a result of re-emergence of invasive streptococcal infections, clinicians should be aware of the differential diagnosis of scarlet fever in patients presenting with cellulitis and skin rash. Early clinical diagnosis is crucial to exclude drug eruptions, prompt initiation of antibiotic treatment, and prevention of the potentially fatal outcome.

  14. Is Procalcitonin a usefull biomarker for the risk stratification of facial cellulitis?

    OpenAIRE

    Bertolus, Chloé; Schouman, Thomas; Aubry, Adeline; Hausfater, Pierre

    2016-01-01

    International audience Backgroundfacial cellulitis is an infectious disease that may require emergency surgical drainage based on clinical assessment. To date, no biological marker has been reported to be useful for risk stratification. Procalcitonin (PCT) is a diagnostic and prognostic sepsis biomarker. We aimed to study the usefulness of PCT dosage for the risk-stratification of facial cellulitis.Patients and methodsThis was a monocentric prospective study conducted in a referral center ...

  15. Histiocytoid giant cellulitis-like Sweet’s syndrome: case report and review of the literature

    OpenAIRE

    So, Jessica Kim; Carlos, Casey A; Frucht, Corey S.; Cohen, Philip R.

    2015-01-01

    Background: Histiocytoid Sweet syndrome is an uncommon variant in which the dermal infiltrate is composed of mononuclear cells with a histiocytic appearance that represent immature myeloid cells. Giant cellulitis-like Sweet syndrome is a recently described variant characterized by relapsing widespread giant lesions. Purpose: We report a unique patient with histiocytoid giant cellulitis-like Sweet syndrome and review the current literature on histiocytoid Sweet syndrome and giant cell...

  16. Amélioration de l’efficacité de l’absorption du rayonnement solaire photovoltaïque par utilisation des nanostructures.

    OpenAIRE

    TRAORE Soumaïla, Amara

    2014-01-01

    L’absorption complète de la lumière solaire dans le silicium cristallin nécessite une épaisseur de matériau de l’ordre de 500 microns, une large fraction de la lumière est perdue par transmission lorsque l’épaisseur de matériau diminue en deçà de 10 microns. Les cellules photovoltaïques en couches minces (cellules de 2ème génération) tentent de contourner les difficultés rencontrées par cette traditionnelle technologie en minimisant la quantité de matière active semi-conductrice par kWh insta...

  17. Peg-Interferon Alfa 2-b Related Cellulitis in a 40 Years Man

    Directory of Open Access Journals (Sweden)

    Shahnaaz Sali

    2016-01-01

    Full Text Available Background: Pegylated interferon and ribavirin are currently one of the accepted treatment for chronic Hepatitis C. Dermatologic complications of interferon have been reported, but to date a few cases of bacterial cellulitis; a rare and severe complication, have been published. Cellulitis is a common infectious process affecting the skin and subcutaneous tissues which results in significant morbidity and holds considerable healthcare costs.Cases Report: Herein, we report a case of chronic hepatitis C genotype 1a who was on medication since 8 weeks prior to developing leg cellulitis, an uncommon pegylated interferon injection site. Considering no other possible risk factors were found to be in favor of bacterial cellulitis, our case is unique in its kind. Some reports reveal necrotizing vasculitis as basis for cutaneous lesions, which could be due to the high concentrations of drug at the injection site, a toxic effect of the diluents, or an immunological reaction.Conclusion: According to the latter mechanism patients could develop bacterial cellulitis in their different organs. Conclusively, we propose the hypothesis of a possible association between cellulitis to occur at any site as the complication of pegylated interferon Alfa 2b and would highlight the role of a careful skin examination that could be an asset in preventing local skin infections.

  18. Bacterial Etiology and Risk Factors Associated with Cellulitis and Purulent Skin Abscesses in Military Trainees

    Science.gov (United States)

    Johnson, Ryan C.; Ellis, Michael W.; Schlett, Carey D.; Millar, Eugene V.; LaBreck, Patrick T.; Mor, Deepika; Elassal, Emad M.; Lanier, Jeffrey B.; Redden, Cassie L.; Cui, Tianyuan; Teneza-Mora, Nimfa; Bishop, Danett K.; Hall, Eric R.; Bishop-Lilly, Kimberly A.

    2016-01-01

    Military trainees are at high risk for skin and soft-tissue infections (SSTIs). Although Staphylococcus aureus is associated with purulent SSTI, it is unclear to what degree this pathogen causes nonpurulent cellulitis. To inform effective prevention strategies and to provide novel insights into SSTI pathogenesis, we aimed to determine the etiology of SSTI in this population. We conducted a prospective observational study in US Army Infantry trainees with SSTI (cutaneous abscesses and cellulitis) from July 2012 through December 2014. We used standard microbiology, serology, and high-throughput sequencing to determine the etiology of SSTI. Furthermore, we compared purported risk factors as well as anatomic site colonization for S. aureus. Among 201 SSTI cases evaluated for SSTI risk factors, cellulitis was associated with lower extremity blisters (P = 0.01) and abscess was associated with methicillin-resistant S. aureus (MRSA) colonization (Pmicrobiome analysis, only 1 leading edge aspirate was culturable (Coagulase-negative Staphylococcus). Microbiome evaluation of aspirate specimens demonstrated that Rhodanobacter terrae was the most abundant species (66.8% average abundance), while abscesses were dominated by S. aureus (92.9% average abundance). Although abscesses and cellulitis share the spectrum of clinical SSTI, the bacterial etiologies as determined by current technology appear distinct. Furthermore, the presence of atypical bacteria within cellulitis aspirates may indicate novel mechanisms of cellulitis pathogenesis. Clinical Trials Registration: NCT01105767. PMID:27780238

  19. Cervical cellulitis and mediastinitis following esophageal perforation: A case report

    Institute of Scientific and Technical Information of China (English)

    Christian A Righini; Basilide Z Tea; Emile Reyt; Karim A Chahine

    2008-01-01

    Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation.Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management.We present the case of a 52-year-old man who sustained an upper esophageal perforation associated with cervical cellulitis and mediastinitis.Following CT-scan evidence of FB penetrating the esophagus,the impacted FB was successfully extracted under rigid esophagoscopy.Direct suture was required to close the esophageal perforation.Cervical and mediastinal drainage were made immediately.Nasogastric tube decompression,broad-spectrum intravenous antibiotics,and parenteral hyperalimentation were administered for 10 d postoperatively.An esophagogram at d 10 revealed no leak at the repair site,and oral alimentation was successfully reinstituted.Conclusion:Rigid endoscope management of FB esophageal penetration is a simple,safe and effective procedure.Primary esophageal repair with drainage of all affected compartments are necessary to avoid life-threatening complications.

  20. Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.

    Science.gov (United States)

    Räßler, F; Lukács, J; Elsner, P

    2016-09-01

    Eosinophilic cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well-designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions. PMID:27357601

  1. Cancer bronchique à petites cellules et grossesse: à propos d'un cas avec revue de la literature

    Science.gov (United States)

    Safini, Fatima; Jjouhadi, Hassan; Chehal, Asmaa; Mernissi, Farida; Wilfried, Akpoo; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2016-01-01

    Le cancer broncho-pulmonaire (CBP) de la femme enceinte est une entité rare, d’évolution péjorative. Cette situation devient de plus en plus fréquente, du fait de l'augmentation du tabagisme chez la femme. La transmission tumorale trans-placentaire avec atteinte fœtale est décrite surtout chez les femmes non traitées. Le traitement est multidisciplinaire et n'est pas bien codifié. Nous rapportons le cas d'une patiente de 23 ans chez qui le diagnostic d'un carcinome bronchique à petites cellules a été fait au cours de sa grossesse. Elle avait bénéficié d'une chimiothérapie pendant la grossesse, bien tolérée. L’évaluation radiologique a objectivé une stabilisation du processus pulmonaire. Le traitement a été complété par une association radio-chimiothérapie concomitante après l'accouchement. PMID:27279957

  2. A case of odontogenic orbital cellulitis causing blindness by severe tension orbit.

    Science.gov (United States)

    Park, Chang Hyun; Jee, Dong Hyun; La, Tae Yoon

    2013-02-01

    We report a very rare case of odontogenic orbital cellulitis causing blindness by severe tension orbit. A 41-yr old male patient had visited the hospital due to severe periorbital swelling and nasal stuffiness while he was treated for a periodontal abscess. He was diagnosed with odontogenic sinusitis and orbital cellulitis, and treated with antibiotics. The symptoms were aggravated and emergency sinus drainage was performed. On the next day, a sudden decrease in vision occurred with findings of ischemic optic neuropathy and central retinal artery occlusion. Deformation of the eyeball posterior pole into a cone shape was found from the orbital CT. A high-dose steroid was administered immediately resulting in improvements of periorbital swelling, but the patient's vision had not recovered. Odontogenic orbital cellulitis is relatively rare, but can cause blindness via rapidly progressing tension orbit. Therefore even the simplest of dental problems requires careful attention.

  3. Group a streptococcal cellulitis in the early puerperium

    Directory of Open Access Journals (Sweden)

    Nikolić Branka

    2011-01-01

    Full Text Available Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerperium. However, there are two main problems with GAS infection in early puerperium and this case report is aimed at reminding on them. The first problem is an absence of awareness that it can be postpartal invasive GAS infection before the microbiology laboratory confirms it, and the second one is that we have little knowledge about GAS infection, in general. Case report. A 32- year-old healthy woman, gravida 1, para 1, was hospitalized three days after vaginal delivery with a 38-hour history of fever, pain in the left leg (under the knee, and head injury after short period of conscious lost. Clinical picture of GAS infection was cellulites. Group A Streptoccocus pyogenes was isolated in vaginal culture. Rapid antibiotic and supportive treatment stopped development of streptococcal toxic shock syndrome (STSS and potential multiorganic failure. Signs and symptoms of the infection lasted 25 days, and complete recovery of the patient almost 50 days. Conclusion. In all women in childbed with a history of fever early after delivery, vaginal and cervical culture specimens should be taken as soon as possible. Early recognition of GAS infection in early puerperium and prompt initiation of antimicrobial drug and supportive therapy can prevent development of STSS and lethal outcome.

  4. Delayed breast cellulitis: An evolving complication of breast conservation

    International Nuclear Information System (INIS)

    Purpose: Delayed breast cellulitis (DBC) is characterized by the late onset of breast erythema, edema, tenderness, and warmth. This retrospective study analyzes the risk factors and clinical course of DBC. Methods and Materials: From 1985 through 2004, 580 sequential women with 601 stage T0-2N0-1 breast cancers underwent breast conserving therapy. Cases of DBC were identified according to accepted clinical criteria: diffuse breast erythema, edema, tenderness, and warmth occurring >3 months after definitive surgery and >3 weeks after radiotherapy. Potential risk factors analyzed included patient comorbidity, operative technique, acute complications, and details of adjunctive therapy. Response to treatment and long-term outcome were analyzed to characterize the natural course of this syndrome. Results: Of the 601 cases, 16%, 52%, and 32% were Stage 0, I, and II, respectively. The overall incidence of DBC was 8% (50/601). Obesity, ecchymoses, T stage, the presence and aspiration of a breast hematoma/seroma, removal of >5 axillary lymph nodes, and arm lymphedema were significantly associated with DBC. The median time to onset of DBC from the date of definitive surgery was 226 days. Ninety-two percent of DBC patients were empirically treated with antibiotics. Fourteen percent required more invasive intervention. Twenty-two percent had recurrent episodes of DBC. Ultimately, 2 patients (4%) underwent mastectomy for intractable breast pain related to DBC. Conclusion: Although multifactorial, we believe DBC is primarily related to a bacterial infection in the setting of impaired lymphatic drainage and may appear months after completion of radiotherapy. Invasive testing before a trial of antibiotics is generally not recommended

  5. De Par en Par (Wide Open), 1993.

    Science.gov (United States)

    De Par en Par, 1993

    1993-01-01

    This document consists of the four issues of the serial "De Par en Par" published during 1993. This serial provides lessons in Spanish for elementary school children. It is written by bilingual education teachers for use in the bilingual classroom. The magazine bases itself on the K-6 curriculum and offers a variety of activities for classroom…

  6. A case of community-acquired Acinetobacter junii-johnsonii cellulitis.

    Science.gov (United States)

    Henao-Martínez, Andrés F; González-Fontal, Guido R; Johnson, Steven

    2012-06-01

    Acinetobacter skin and soft tissue infection outside of the traumatic wound setting are rare occurrences. The majority of cases occur in the presence of significant comorbilities and by Acinetobacter baumanii. Herein a case is reported of community-onset, health-care-associated, non-traumatic cellulitis caused by Acinetobacter, species junii-johnsonii with bacteremia. This is the first reported case of Acinetobacter junii-johnsonii skin and soft tissue infection. Hemorrhagic bullae might be one of the clinical features of Acinetobacter cellulitis. PMID:23242290

  7. Par-tjek Manualen

    DEFF Research Database (Denmark)

    Trillingsgaard, Tea; Due, Mattias Stølen; Nørr Fentz, Hanne;

    Par-tjek er et tilbud til par, der ønsker at styrke forholdet og forebygge vanskeligheder. Et Par-tjek består af et indledende online spørgeskema efterfulgt at to samtaler med en psykolog eller lignende vejleder. Ved den sidste samtale modtager parret en personlig feedback-rapport, som de kan...

  8. Current trends in treatment outcomes of orbital cellulitis in a tertiary hospital in Southern Nigeria

    Directory of Open Access Journals (Sweden)

    Odarosa M Uhumwangho

    2016-01-01

    Full Text Available Background: Orbital cellulitis refers to the inflammation or infection of the soft tissues of the orbit located behind the orbital septum. Aim: To determine the current trends in the outcomes following the management of orbital cellulitis in a tertiary hospital in Southern Nigeria. Patients and Methods: A retrospective review of medical records of patients with orbital cellulitis from January 2008 to December 2014 was conducted. The age, sex, duration of symptoms, predisposing factors, clinical findings, laboratory/radiological investigations, treatment provided, complications, and follow-up were recorded. Results were analyzed with SPSS Version 21 program. Results: Forty-two patients were seen made of 17 (40.5% males and 25 (59.5% females with a mean age of 18.2 ± 18.7 years of which children 6/18 at presentation, 38 (82.6% and at discharge, 39 (84.8%. The mean duration of presenting complaints was 15.5 ± 31.6 days. Patients who presented early were less likely to develop complications, P = 0.003. The most common complication was exposure keratopathy in 8 (44.4% eyes. The only surgical intervention performed was incision and drainage of abscess in 3 (7.1% eyes. No patient came for follow-up. Conclusion: Prompt institution of effective antibiotics and management of complications that may arise improves prognosis of orbital cellulitis.

  9. Panophthalmitis with orbital cellulitis following glaucoma drainage implant surgery in a pediatric patient

    Directory of Open Access Journals (Sweden)

    Bruno L. B. Esporcatte

    2016-04-01

    Full Text Available ABSTRACT Here we report a case of childhood glaucoma refractory to angle and trabeculectomy surgery. The patient was treated with an Ahmed™ drainage implant that was subsequently complicated by rapid-onset panophthalmitis and orbital cellulitis. Intravenous and intravitreal antibiotic therapy was initiated and the drainage tube was removed. The infectious process resolved within 3 weeks; however, phthisis bulbi developed subsequently.

  10. Use of HMPAO-{sup 99m}Tc in radio-labelling endothelial cells: application to the study of the behaviour of endothelialized vascular prostheses under shearing constraint; Utilisation de HMPAO-{sup 99m}Tc pour le radio-marquage de cellules endotheliales: application pour etudier le comportement de protheses vasculaires endothelialisees sous contraintes de cisaillement

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Ph.; Bareille, R.; Brouillaud, B.; Barthe, N.; Rouais, F.; Bordenave, L. [Laboratoire de Biophisique, CHU-Bordeaux, 33076 Bordeaux (France)

    1997-12-31

    Insemination of the low-caliber vascular prostheses at the level of their endo-luminal surfaces by a monolayer of endothelial cells (EC) prior to their implantation diminishes their thrombogen character and increases their long-term expectation of permeability in humans. The aptitude of EC of remaining adherent to their support when exposed to the constraints of circulatory flux must be studied in vitro and all the authors quantify these adherence by the measurement of the loss of gamma activity of the vascular prosthesis after radiolabelling of EC by {sup 111}In oxinate. In this work EC of human origin, adherent to the culture surfaces were radiolabelled by HMPAO-{sup 99m}Tc and optimal conditions of the labelling were determined: the effect of increasing concentrations of HMPAO and increasing activities of HMPAO-{sup 99m}Tc on the viability and metabolic activity of EC; the influence of the temperature and of the time of touching on the labelling yield. Subsequently, this conditions were applied to EC having cultivated a innovative vascular prosthesis. Surface micro-auto-radiographies were realized. The best compromise was obtained with 10 MBq/10{sup 6} EC (40 {mu}g of HMPAO/10{sup 6} EC) corresponding to a labelling yield of 13.7 {+-} 0.7 after 3 hours of contact at 37 deg. C. The micro-auto-radiographies allow visualization of the intracellular radioactivity distribution. The study of adherence of EC to the vascular prosthesis, under shearing constraints, by means of a radiotracer provides numerous advantages vs current utilisation of {sup 111}In oxinate

  11. Etude des phenomenes chimiques au contact entre le bloc cathodique et la barre collectrice d'une cellule d'electrolyse d'aluminium

    Science.gov (United States)

    Lebeuf, Martin

    La production d'aluminium est une industrie importante au Québec. Les propriétés de ce métal le vouent à de multiples usages présents et futurs dans le cadre d'une économie moderne durable. Toutefois, le procédé Hall-Héroult est très énergivore et des progrès demeurent donc nécessaires pour en diminuer les coûts financiers et environnementaux. Parmi les améliorations envisageables de la cellule d'électrolyse se trouve le contact entre la cathode et la barre collectrice, qui doit offrir une faible résistivité au passage du courant électrique. En cours d'opération de la cellule, ce contact a tendance à se dégrader, générant des pertes énergétiques significatives. Les causes de cette dégradation, pouvant provenir de phénomènes chimiques, thermiques, mécaniques et/ou électriques, demeurent mal comprises. Le but du présent projet était donc d'étudier les phénomènes chimiques se produisant au contact bloc-barre de la cellule d'électrolyse Hall-Héroult. En premier lieu, un aspect crucial à considérer est la pénétration du bain électrolytique dans la cathode, car des composés de bain atteignent éventuellement la barre collectrice et peuvent y réagir. A cet effet, une méthode novatrice a été développée afin d'étudier les cathodes et la pénétration du bain dans celles-ci à l'aide de la microtomographie à rayons X. Cette méthode rapide et efficace s'est avérée fort utile dans le projet et a un potentiel important pour l'étude future des cathodes et des phénomènes qui s'y produisent. Ensuite, une cellule d'électrolyse rectangulaire à petite échelle a été développée. Plusieurs phénomènes observés 'en industrie sur des autopsies de cellules post-opération et rapportés dans la littérature ont été reproduis avec succès à l'aide de cette cellule expérimentale. Puis, des tests sans électrolyse, ciblant l'effet du bain électrolytique sur l'acier, ont aussi été conçus et complétés afin de s

  12. Nine years′ review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

    Directory of Open Access Journals (Sweden)

    Datta G Pandian

    2011-01-01

    Full Text Available Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Settings and Design : Retrospective descriptive case study done in a tertiary care hospital in South India. Material and Methods: The in-patient records of patients with preseptal and orbital cellulitis were reviewed from 1998 to 2006. The factors reviewed included ocular findings aiding in the distinction of the two clinical conditions, the duration of symptoms, the duration of hospital stay, microbiological culture report of pus or wound swab, blood culture, drugs used for treatment, the response to therapy and complications. Statistical Analysis Used: Descriptive analysis. Results: One hundred and ten cases, 77 patients with preseptal cellulitis and 33 patients with orbital cellulitis were reviewed. Five percent of children and 21% of adults presented with cutaneous anthrax contributing to preseptal cellulitis. Thirty-nine percent cases with orbital cellulitis were caused by methicillin-resistant Staphylococcus aureus (MRSA. Conclusions: This study has helped in identifying organisms which cause orbital infections, especially community-acquired MRSA. It indicates the need for modifying our empirical antimicrobial therapy, especially in orbital cellulitis.

  13. Pars Injuries in Athletes.

    Science.gov (United States)

    Oren, Jonathan H; Gallina, Jason M

    2016-03-01

    Pars injuries are common causes of low back pain in adolescent athletes. Workup traditionally has included lumbar radiographs with oblique views and single-photon emission computed tomography (SPECT). However, recent literature has demonstrated the accuracy of MRI as a diagnostic modality. Acute injuries may be amenable to bracing with the goal of a healed lesion. Most cases of spondylolysis will result in asymptomatic non-union, though pars repair is an option for symptomatic pars defects without spondylolisthesis. PMID:26977552

  14. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    OpenAIRE

    Soma Mukherjee; Surbhi Sharma; Laxmi Maru

    2013-01-01

    Ludwig's angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregn...

  15. Quantification des cellules viables de P. phosphoreum dans les pavés de saumon cru par PCR temps reel

    DEFF Research Database (Denmark)

    Macé, Sabine; Mamlouk, Kelthoum; Chipchakova, Stoyka;

    de 350 pb sur le gène de la gyrase subunit B de P.phosphoreum. Leur spécificité a été démontrée en utilisant l’ADN de 88 souches bactériennes de 52 espèces bactériennes différentes. En utilisant ces amorces pour quantifier une culture pure de P.phosphoreum, une bonne corrélation (R2 de 0.99) a été...

  16. Installation solaire de production hydrogène par l'électrolyse de vapeur d'eau

    OpenAIRE

    Miri, Rachid; Mraoui, Abdelhamid

    2007-01-01

    International audience; Cette étude porte sur la conception d'une installation de production d'hydrogène par électrolyse de vapeur d'eau à hautes températures (700-1000°C) dont les ressources énergétiques sont solaires : l'alimentation en vapeur d'eau est assurée par une centrale solaire à concentration et le courant électrique est fourni par des cellules Photovoltaïques. La simulation numérique de la production d'hydrogène, pour l'installation proposée, est faite en se basant sur les équatio...

  17. Mycobacterium avium-intracellulare cellulitis occurring with septic arthritis after joint injection: a case report

    Directory of Open Access Journals (Sweden)

    Murdoch David M

    2007-02-01

    Full Text Available Abstract Background Cellulitis caused by Mycobacterium avium-intracellulare has rarely been described. Mycobacterium avium-intracellulare is a rare cause of septic arthritis after intra-articular injection, though the causative role of injection is difficult to ascertain in such cases. Case presentation A 57-year-old with rheumatoid arthritis treated with prednisone and azathioprine developed bilateral painful degenerative shoulder arthritis. After corticosteroid injections into both acromioclavicular joints, he developed bilateral cellulitis centered over the injection sites. Skin biopsy showed non-caseating granulomas, and culture grew Mycobacterium avium-intracellulare. Joint aspiration also revealed Mycobacterium avium-intracellulare infection. Conclusion Although rare, skin and joint infections caused by Mycobacterium avium-intracellulare should be considered in any immunocompromised host, particularly after intra-articular injection. Stains for acid-fast bacilli may be negative in pathologic samples even in the presence of infection; cultures of tissue specimens should always be obtained.

  18. Facing the danger zone: the use of ultrasound to distinguish cellulitis from abscess in facial infections.

    Science.gov (United States)

    Lewis, Dywanda L; Butts, Christine J; Moreno-Walton, Lisa

    2014-01-01

    Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1) emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2) demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3) depict an instance where ultrasound detected an abscess when computed tomography (CT) scan did not. PMID:24851189

  19. Facing the Danger Zone: The Use of Ultrasound to Distinguish Cellulitis from Abscess in Facial Infections

    Directory of Open Access Journals (Sweden)

    Dywanda L. Lewis

    2014-01-01

    Full Text Available Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1 emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2 demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3 depict an instance where ultrasound detected an abscess when computed tomography (CT scan did not.

  20. Unilateral proptosis and orbital cellulitis in eight African hedgehogs (Atelerix albiventris).

    Science.gov (United States)

    Wheler, C L; Grahn, B H; Pocknell, A M

    2001-06-01

    Eight African hedgehogs (Atelerix albiventris) were presented with unilateral proptosis. Six animals presented specifically for an ocular problem, whereas two had concurrent neurologic disease. Enucleation and light microscopic examination of tissues was performed in five animals, and euthanasia followed by complete postmortem examination was performed in three animals. Histopathologic findings in all hedgehogs included orbital cellulitis, panophthalmitis, and corneal ulceration, with perforation in seven of eight eyes. The etiology of the orbital cellulitis was not determined, but it appeared to precede proptosis. Orbits in hedgehogs are shallow and the palpebral fissures are large, which may predispose them to proptosis, similar to brachycephalic dogs. This clinical presentation was seen in 15% (8/54) of African hedgehogs presented to the Western College of Veterinary Medicine over a 2-yr period from January 1995 to December 1996 and warrants further investigation. PMID:12790427

  1. Prevalence and Epidemiological Factors Involved in Cellulitis in Korean Patients With Lymphedema

    OpenAIRE

    Park, Sae In; Yang, Eun Joo; Kim, Dong Kyu; Jeong, Ho Joong; Kim, Ghi Chan; Sim, Young-Joo

    2016-01-01

    Objective To evaluate the prevalence and associated factors involved in cellulitis with lymphangitis among a group of Korean patients who were being treated for lymphedema. We present our epidemiologic research and we also report a systematic review of these types of cases. Methods This was a retrospective medical record study among 1,246 patients diagnosed with lymphedema. The study was carried out between January 2006 and December 2012 at the Kosin University Gospel Hospital and Seoul Natio...

  2. A Woman with Unilateral Rash and Fever: Cellulitis in the Setting of Lymphedema

    Directory of Open Access Journals (Sweden)

    Melissa Joseph

    2015-01-01

    Full Text Available Cellulitis in the setting of lymphedema is an uncommon but clinically important presentation to the emergency department. Stagnant lymph is an ideal medium for bacterial growth and progression can be rapid due to decreased ability to fight infection in the affected area. Infections are commonly caused by gram-positive cocci, though blood cultures are often negative. Treatment should be aimed at rapid initiation of antibiotics targeting these species. There may be a role for antibiotic prophylaxis in recurrent cases.

  3. Disseminated cryptococcosis presenting as cutaneous cellulitis in an adolescent with systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Ellen Simionato Valente

    2015-06-01

    Full Text Available We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

  4. Disseminated Cryptococcosis Presenting as Cutaneous Cellulitis in an Adolescent With Systemic Lupus Erythematosus.

    Science.gov (United States)

    Valente, Ellen Simionato; Lazzarin, Mauricio Costa; Koech, Bruno Lopes; da Rosa, Ralph Vighi; de Almeida, Rafael; de Oliveira, Umberto Lopes; Neugebauer, Maria Gertrudes Fernandes Pereira; Sacco, Alexander Gonüalves

    2015-04-15

    We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

  5. Radionuclide imaging in early detection of childhood osteomyelitis and its differentiation from cellulitis and bone infarction

    International Nuclear Information System (INIS)

    In children, radionuclide skeletal imaging with sup(99m)Tc-phosphate compounds is significantly more sensitive than roentgenographic studies in the early detection of osteomyelitis and septic arthritis. The scintigraphic patterns are usually characteristic. Cellulitis and some cases of early infarction are easily differentiated from osteomyelitis. However, some cases of infarction are indistinguishable from osteomyelitis on sup(99m)Tc-phosphate scan. In these cases 67Ga-citrate may prove helpful

  6. Phalangeal fractures and metacarpophalangeal luxations subsequent to post-traumatic osteomyelitis and cellulitis in a dog.

    Science.gov (United States)

    Langley-Hobbs, S J; Lascelles, B D X

    2004-07-01

    A working Border collie suffered a puncture wound to the metacarpal pad. No fractures or luxations were identified at initial presentation. Treatment was instigated with various antibacterials for a period of months. At subsequent visits, the dog's condition progressed with development of metacarpophalangeal joint luxation and phalangeal fractures secondary to cellulitis and chronic osteomyelitis. Amputation was curative. Prompt treatment of the acute condition with debridement and drainage may have prevented osteomyelitis becoming established in the first instance. PMID:15266860

  7. European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate

    Directory of Open Access Journals (Sweden)

    Tsironi Evangelia E

    2012-05-01

    Full Text Available Abstract Background Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed description of a community-associated methicillin-resistant S. aureus ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial acquisition and treatment selection are also discussed. Case presentation A 28-day-old Caucasian boy was referred to our hospital with the diagnosis of right orbital cellulitis. His symptoms included right eye proptosis, periocular edema and redness. Empirical therapy of intravenous daptomycin, rifampin and ceftriaxone was initiated. The culture of pus yielded a methicillin-resistant S. aureus isolate and the molecular analysis revealed that it was a Panton-Valentine leukocidine-positive ST80 strain. The combination antimicrobial therapy was continued for 42days and the infection was successfully controlled. Conclusions Clinicians should be aware that young infants, even without any predisposing condition, are susceptible to orbital cellulitis caused by community-associated methicillin-resistant S. aureus. Prompt initiation of the appropriate empirical therapy, according to the local epidemiology, should successfully address the infection, preventing ocular and systemic complications.

  8. [Cervico-facial cellulitis during pregnancy: about a series of 10 cases in Mali].

    Science.gov (United States)

    Doumbia-Singare, K; Timbo, S K; Keita, M; Ag Mohamed, A; Guindo, B; Soumaoro, S

    2014-12-01

    The objective of this work was to analyze the predisposing factors, diagnostic and therapeutic aspects of cervico-facial cellulitis on pregnancies and to determine maternal-fetal prognosis. We conducted a longitudinal observational descriptive study from January 2011 to March 2013 including records from pregnant women with cervicofacial cellulitis treated at the Oto-Rhino-Laryngology (ORL) and cervico-facial surgery department at Gabriel Touré Hospital in Bamako. Ten women met our inclusion criteria. The median age was 23 years. The entry way was dental in all cases. Three women had taken antibiotics and 3 others antibiotics associated with non steroidal anti-inflammatory. The medico-surgical treatment had permitted to cure 8 cases. Two cases of death were recorded and 4 cases of stillbirths. The cervico-facial cellulitis during pregnancy is a serious pathology that can be life-threatening to the mother and or child. Prevention is based on the control of dental status and informing women about the importance of dental hygiene. PMID:25304000

  9. Par Pond water balance

    International Nuclear Information System (INIS)

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  10. Contribution à la clarification du régime juridique de la responsabilité de l’Etat résultant d’un placement en cellule de dégrisement

    OpenAIRE

    Edouard, Thierry

    2014-01-01

    Le 7 janvier 2011, les gendarmes du village de Camopi (Guyane française) étaient requis par une jeune femme se plaignant de violences conjugales. Le fauteur, M. A., finalement interpellé dans la soirée, est conduit à la brigade territoriale. Son état d’ébriété manifeste justifiait qu’il soit placé en cellule de dégrisement, dans l’attente d'une garde à vue. Au petit matin, l’époux violent est retrouvé sans vie, pendu au cordon de son calimbé. Au-delà du relatif retentissement médiatique, cett...

  11. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian;

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...

  12. INSULIN INDUCES NITRIC OXIDE PRODUCTION IN BOVINE AORTIC ENDOTHELIAL CELLS

    Institute of Scientific and Technical Information of China (English)

    李慧丽; 黄定九

    2000-01-01

    ffeStun6. ObjeCtif Dens cette dtude nons avons ewilue l' effet de l' insuline sur ba Proliferation cellulaire, liberationd' oxide nitrique et l' expression gdrktique de synthase d' oxide nitrique dens la cellule endotheliale aortique bovine. methIn mitogdthe est evalude per la ndthae M7T. In Production de NO dans ie alga en culture est determine per la reactionGness. In technique quantitative RT/PCR est utility pour quantifier ie niveau de sWthase d' oxide nitrique mRNA dens la cellule endotheliale aortique...

  13. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  14. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Soma Mukherjee

    2013-01-01

    Full Text Available Ludwig′s angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregnancy, lest life-threatening complications like Ludwig′s angina occur, complicating the course of pregnancy.

  15. Amelioration_du_Rendement_Energetique_de_Cellules_Photovoltaïques_en_Couches_Minces_a_base_de_CZTS.

    OpenAIRE

    BOUDJERAD_epouse_MEGHNINE, Fatiha

    2014-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de CuZnSnS4 (CZTS) semble prometteur. En effet, le rendement de ces cellules a dépassé les 30% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logic...

  16. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    , results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  17. Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis

    Directory of Open Access Journals (Sweden)

    Rebecca Sin Mei Lim

    2013-01-01

    Full Text Available We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.

  18. Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis

    Directory of Open Access Journals (Sweden)

    Giuseppe Valacchi

    2015-08-01

    Full Text Available Objectives: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. Material and Methods: We used the emergency department (ED visits data in Edmonton, Canada for the period from 1992 (April to 2002 (March. We retrieved all the diagnosed ED visits for cellulitis and pharyngitis. Case-crossover design was used to study potential association between ozone and those visits. Conditional logistic regression was used to estimate odds ratios (OR and their 95% confidence intervals (95% CI. Results: The results are reported for the interquartile range (IQR = 17.9 ppb for 8 h maximum ozone. Positive and statistical significant results were obtained as follows: for lags from 0 to 3 (OR = 1.07, 95% CI: 1.03–1.12, lag 2; for lags from 0 to 6 days (OR = 1.08, 95% CI: 1.03–1.12, lag 3; for lags from 0 to 4 (OR = 1.06, 95% CI: 1.03–1.09, for lag 2 and 3. Conclusions: The findings suggest the response to exposure to ambient ground-level ozone for skin and pharyngitis considered separately and jointly.

  19. A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.

    LENUS (Irish Health Repository)

    Quirke, M

    2014-11-01

    To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-referral, symptom duration of more than 48 hours and absence of pre-EO antibiotic therapy.

  20. Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases

    Directory of Open Access Journals (Sweden)

    Souleymane Brah

    2011-01-01

    Full Text Available Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. We describe three cases of severe infection due to C. fetus with cellulitis at presentation, but without any gastrointestinal symptoms, occurring in patients with acquired hypogammaglobulinemia.

  1. Production de biohydrogène par électro-catalyse microbienne

    OpenAIRE

    Rousseau, Raphaël

    2013-01-01

    La cellule d’électrolyse microbienne (CEM) permet la conversion de la biomasse en dihydrogène via un apport théorique en énergie électrique 10 fois moindre que celui de l’électrolyse de l’eau. Un tel procédé fonctionne via la technologie des bioanodes, qui permet la catalyse de l’oxydation de la biomasse en CO2 par l’intermédiaire d’un biofilm électro-actif. Les travaux exposés dans ce manuscrit de thèse ont pour but l’optimisation des performances de la bioanode, la compréhension des mécanis...

  2. suPAR: the molecular crystal ball

    DEFF Research Database (Denmark)

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. ...

  3. Facial and Periorbital Cellulitis due to Skin Peeling with Jet Stream by an Unauthorized Person

    Directory of Open Access Journals (Sweden)

    Asli Feride Kaptanoglu

    2014-01-01

    Full Text Available Technologies and devices for cosmetic procedures are developing with each passing day. However, increased and unauthorized use of such emerging technologies may also lead to increases in unexpected results and complications as well. Here, we report a case of facial cellulitis after a “beauty parlor” session of skin cleaning with jet stream peeling device in 19-year old female patient for the first time. Complications due to improper and unauthorized use of jet stream peeling devices may also cause doubts about the safety and impair the reputation of the technology as well. In order to avoid irreversible complications, local authorities should follow the technology and update the regulations where the dermatologists should take an active role.

  4. [Macrolane®: A severe case of calf cellulitis after modeling injection].

    Science.gov (United States)

    Chaput, B; Eburdery, H; Crouzet, C; Grolleau, J-L; Chavoin, J-P; Garrido, I

    2012-02-01

    In recent years, the market for resorbable injectables has been steadily expanding. The European Community's seal of approval (CE) is a sufficient guaranty to get them distributed. These injectables do not require official approval because they are considered to be "implantable medical devices" and not medicines. Macrolane(®)is a hyaluronic acid in gel form (NASHA [non-animal stabilized hyaluronic acid]) and has been on the French market since 2007. It can be injected into all areas except the face. It is highly cross-linked which, while slowing its absorption into the body, can also leave long-lasting residues. We report the first case of cellulitis after injection into the calf by a practitioner in his office.

  5. 眼外伤致眶蜂窝组织炎的护理%Nursing of Oribital Cellulitis Caused by Eye Injury

    Institute of Scientific and Technical Information of China (English)

    林丽萍; 胡淑英; 陈少娜

    2002-01-01

    To sum up 20 cases of nursing Oribital cellulitis caused by eye injury and suggest that it is important fornursing to pay close attention to patient's condition, to prevent cross infection and psychological nursing and to publicizehygiene element knowledge.

  6. Eduquer par la musique

    OpenAIRE

    Zhe, Ji

    2011-01-01

    La politique et l’éducation sont indissociables dans les tentatives de promouvoir le confucianisme en Chine contemporaine. L’union alors célébrée du sacré, du pouvoir et du savoir s’inscrit en tension avec une modernité d’abord caractérisée par la différenciation des institutions et des valeurs. Partant de ce constat, l’article étudie le cas particulier d’une société engagée depuis 2000 dans l’initiation des enfants à la musique classique et dans la promotion de la « culture de soi » chez les...

  7. ParB spreading requires DNA bridging

    NARCIS (Netherlands)

    Graham, Thomas G. W.; Wang, Xindan; Song, Dan; Etson, Candice M.; van Oijen, Antoine M.; Rudner, David Z.; Loparo, Joseph J.

    2014-01-01

    The parABS system is a widely employed mechanism for plasmid partitioning and chromosome segregation in bacteria. ParB binds to parS sites on plasmids and chromosomes and associates with broad regions of adjacent DNA, a phenomenon known as spreading. Although essential for ParB function, the mechani

  8. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    Directory of Open Access Journals (Sweden)

    Juan S. Lasa

    2012-08-01

    Full Text Available La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB. Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celulitis. Se analizaron retrospectivamente los registros clínicos de los pacientes con este diagnóstico al ingreso entre junio de 2007 y marzo de 2010. Se evaluaron los datos poblacionales, presencia de comorbilidades, y resultados de los cultivos. En ese período, se internaron 140 pacientes con diagnóstico de celulitis y a todos ellos se les realizó hemocultivo y cultivos de PPB. Setenta y cuatro eran varones (52.8%. La edad promedio: 47.5 ± 19.7 años (rango 16-94. El 40% tuvo cultivos positivos de PPB, en los que el Staphylococcus aureus meticilino resistente (SAMR fue el germen más frecuentemente aislado (35.7%; la prevalencia de bacteriemia fue del 8.6%, en donde el germen más frecuente fue Streptoccocus Beta hemolítico, grupo G (33% del total de hemocultivos positivos. La bacteriemia se asoció significativamente a mayor estadía hospitalaria (10.5 ± 8.9 vs. 4.9 ± 6, p = 0.004. Se asoció con mayor riesgo de hemocultivo positivo a ser diabético, tener cultivo de PPB positivo, consumo de alcohol y/o enfermedad pulmonar obstructiva crónica.Cellulitis is an acute inflammation of dermis and subcutaneous tissue, usually complicating wounds, ulcers, or dermatosis. Even though in these cases it is recommended to perform culture from skin and soft tissue samples, the utility of blood cultures remains controversial due to the low frequency of positive results. Here we report the prevalence of bacteremia in patients with cellulitis admitted in our

  9. A case of cellulitis of the hands caused by a predatory bird attack

    Directory of Open Access Journals (Sweden)

    M Adil Abbas Khan

    2011-04-01

    Full Text Available Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an 80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  10. A case of cellulitis of the hands caused by a predatory bird attack

    Institute of Scientific and Technical Information of China (English)

    M Adil Abbas Khan; Mohammed Farid; Zain A Sobani; Syed Nadir Ali; Huzaifa Malick; Maryam Baqir; Hasanat Sharif; M Asim Beg

    2011-01-01

    Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  11. Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report

    Directory of Open Access Journals (Sweden)

    Probst Corina

    2010-08-01

    Full Text Available Abstract Background Cryptococcus neoformans is an encapsulated yeast and the most frequent cryptococcal species found in humans. Cryptococcosis is considered an opportunistic infection as it affects mainly immunosuppressed individuals. In humans, C. neoformans causes three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and wound or cutaneous cryptococcosis. Case Presentation An 81-year-old woman developed severe necrotizing cellulitis on her left arm without any preceding injury. The patient had been treated with systemic corticosteroids over twenty years for rheumatoid arthritis (RA. Skin biopsies of the wound area were initially interpreted as cutaneous vasculitis of unknown etiology. However, periodic acid Schiff staining and smear analysis later revealed structures consistent with Cryptococcus neoformans, and the infection was subsequently confirmed by culture. After the initiation of therapy with fluconazole 400 mg per day the general condition and the skin ulcers improved rapidly and the patient was discharged to a rehabilitation facility. Subsequently surgical debridement and skin grafting were performed. Conclusions Opportunistic infections such as cryptococcosis can clinically and histologically mimic cutaneous vasculitis and have to be investigated rigorously as a differential diagnosis in immunosuppressed patients.

  12. Laser Capture Microdissection of Feline Streptomyces spp Pyogranulomatous Dermatitis and Cellulitis.

    Science.gov (United States)

    Traslavina, R P; Reilly, C M; Vasireddy, R; Samitz, E M; Stepnik, C T; Outerbridge, C; Affolter, V K; Byrne, B A; Lowenstine, L J; White, S D; Murphy, B

    2015-11-01

    Suspected Streptomyces spp infections were identified in 4 cats at UC Davis Veterinary Medical Teaching Hospital between 1982 and 2011. Three had ulcerated, dark red mycetomas involving the dermis, subcutis, and fascia with fistulous tracts and/or regional lymphadenopathy. One cat had pyogranulomatous mesenteric lymphadenitis. Granulomatous inflammation in all cats contained colonies of Gram-positive, non-acid-fast organisms. All 4 cats failed to respond to aggressive medical and surgical treatment and were euthanized. Laser capture microdissection (LCM) was used to selectively harvest DNA from the affected formalin-fixed, paraffin-embedded (FFPE) tissues. Cloned amplicons from LCM-derived tissue confirmed the presence of Streptomyces spp in the dermatitis cases. Amplicons from the remaining cat with peritoneal involvement aligned with the 16S ribosomal RNA gene for Actinomycetales. Usually considered a contaminant, Streptomyces spp can be associated with refractory pyogranulomatous dermatitis and cellulitis in cats with outdoor access. LCM is useful in the diagnosis of bacterial diseases where contamination may be an issue. PMID:25516065

  13. Laser Capture Microdissection of Feline Streptomyces spp Pyogranulomatous Dermatitis and Cellulitis.

    Science.gov (United States)

    Traslavina, R P; Reilly, C M; Vasireddy, R; Samitz, E M; Stepnik, C T; Outerbridge, C; Affolter, V K; Byrne, B A; Lowenstine, L J; White, S D; Murphy, B

    2015-11-01

    Suspected Streptomyces spp infections were identified in 4 cats at UC Davis Veterinary Medical Teaching Hospital between 1982 and 2011. Three had ulcerated, dark red mycetomas involving the dermis, subcutis, and fascia with fistulous tracts and/or regional lymphadenopathy. One cat had pyogranulomatous mesenteric lymphadenitis. Granulomatous inflammation in all cats contained colonies of Gram-positive, non-acid-fast organisms. All 4 cats failed to respond to aggressive medical and surgical treatment and were euthanized. Laser capture microdissection (LCM) was used to selectively harvest DNA from the affected formalin-fixed, paraffin-embedded (FFPE) tissues. Cloned amplicons from LCM-derived tissue confirmed the presence of Streptomyces spp in the dermatitis cases. Amplicons from the remaining cat with peritoneal involvement aligned with the 16S ribosomal RNA gene for Actinomycetales. Usually considered a contaminant, Streptomyces spp can be associated with refractory pyogranulomatous dermatitis and cellulitis in cats with outdoor access. LCM is useful in the diagnosis of bacterial diseases where contamination may be an issue.

  14. Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.

    Science.gov (United States)

    Hau, Estelle; Bouaziz, Jean-David; Lafaurie, Matthieu; Saussine, Anne; Masson, Vincent; Rausky, Jonathan; Bagot, Martine; Guibal, Fabien

    2016-03-01

    Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.

  15. Facial Candida albicans cellulitis occurring in a patient with oral submucous fibrosis and unknown diabetes mellitus after local corticosteroid injection treatment.

    Science.gov (United States)

    Chen, Hsin-Ming; Shih, Chiang-Ching; Yen, K Lawrence; Wang, Sheng-Ming; Kuo, Ying-Shiung; Kuo, Mark Yen-Ping; Chiang, Chun-Pin

    2004-04-01

    Facial cellulitis caused by odontogenic bacterial infection is frequently encountered; however, facial cellulitis caused by Candida albicans infection is rarely found. A patient with oral submucous fibrosis (OSF) and unknown diabetes mellitus (DM) was treated in our out-patient dental clinic by biweekly submucosal injection of 40 mg triamcinolone acetonide into bilateral buccal mucosae plus forced mouth opening performed by the two hands of the clinician. The interincisal distance of the patient improved from 28 to 48 mm after four times of steroid injection. The symptoms and signs of OSF also improved markedly. Unfortunately, facial candidal cellulitis occurred 2 months after the last time of steroid injection treatment. The infection was cured by incision and drainage, intravenous administration of amphotericin B (100 mg once a day for a week), and an appropriate medical control of DM. No recurrence of facial cellulitis was found during the follow-up period of 18 months. To prevent the occurrence of facial cellulitis after a high-dose steroid therapy, some prophylactic procedures should be taken before the initiation of the steroid treatment.

  16. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  17. Implications and applications of systematic reviews for evidence-based dentistry and comparative effectiveness research: A sample study on antibiotics for oro-facial cellulitis treatment

    Directory of Open Access Journals (Sweden)

    Quyen Bach

    2015-01-01

    Full Text Available Introduction: Comparative effectiveness and efficacy research for analysis and practice (CEERAP was performed to assess the effects of penicillin-based versus erythromycin-based antibiotic treatments in patients with skin and soft tissue infections (SSTIs including cellulitis, impetigo, and erysipelas. Because SSTIs, especially orofacial cellulitis, are volatile infectious diseases of a life-threatening nature, research on the most efficacious remedies is necessary. Methods: The stringent bibliome yielded three systematic reviews, which were examined for quality of research synthesis protocol and clinical relevance. Results: The sample size of three, rendered the statistical analyses and cumulative meta-analysis problematic. Conclusion: The systematic review outlined here should aid in increasing clinical awareness, improving patient health literacy, and promoting consensus of the best evidence base (BEB to mitigate the threat of sepsis and potential death caused by cellulitis infections.

  18. [Infectious cellulitis of the face complicating injection for esthetic nasolabial sulcus by hyaluronic acid: report of seven cases].

    Science.gov (United States)

    Chader, H; Bosc, R; Hersant, B; Lange, F; Hermeziu, O; Zehou, O; Chosidow, O; Meningaud, J-P

    2013-12-01

    We report a case series of seven patients with bacterial cellulitis of the face complicating a filler injection for cosmetic reason, treated in a university hospital from 2005 to 2012. There were seven women aged 34 to 57 years. Two patients had a deep collection requiring surgical excision combined with antibiotics. Five patients were treated with antibiotics only. In two cases the bacteria was found streptococcus A and in one case Staphylococcus aureus. One patient required hospitalization in an intensive care unit. Only patients who needed surgical treatment showed moderate aesthetic sequelae.

  19. Tumeur à cellules géantes du fémur proximal traitée par arthroplastie totale de hanche

    Science.gov (United States)

    Mhammdi, Younes; Kharmaz, Mohamed

    2016-01-01

    The authors report the case of a giant cell tumor grade 1 of the proximal femur, diagnosed in a young patient of 18 years. The diagnosis was suspected on a standard x-ray complemented by MRI, it was confirmed on histological examination after biopsy. The tumor was a metaphyseal-epiphyseal location above the level of the femoral cut on preoperative planning. The management had combined two surgical techniques, with a marginal resection of the femoral head and neck, and femoral curettage-filling of the metaphyseal region with implantation of a total cemented hip prosthesis. After 2 years of follow up, the result is very satisfactory with good functional recovery and no signs of recurrence. PMID:27279937

  20. Treatment of radioinduced skin burns by adult stem cells;Traitement des brulures cutanees radio-induites par cellules souches adultes

    Energy Technology Data Exchange (ETDEWEB)

    Lataillade, J.J.; Prat, M. [Hopital Militaire Percy, Centre de Transfusion Sanguine des Armees, Dept. Recherches et Therapies Cellulaires, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Bey, E. [Hopital Militaire Percy, Service de Chirurgie Plastique, 92 - Clamart (France)

    2009-12-15

    In the area of skin injuries caused by ionizing radiations; the recent opportunity give us the the possibility to manage victims of radiation accidents with skin acute symptoms of irradiation. The approach of cell therapy developed for these patients could be in a second time, used for other types of injuries as thermal burns and the injuries linked to overexposure in radiotherapy. In spite of the diversity of approaches of allogeneic and autologous transplantation, the prognosis of deep and extended radioinduced burns is not completely satisfying because of inflammatory recurrences, origin of graft failures. The stem cells have been used in association. The stem cells were got from sampling of autologous bone marrow after an expansion in vitro from 15 to 17 days. The cultures were realised in medium with 8% of platelet lysate (clinical grade). The cells have been given by injection in complement of epidermis auto graft. A spectacular effect was noticed the day after the injection, but disappearing in some days encouraging to realize supplementary injections. An effect of the quickness and the quality of the graft success is appeared significant too. no necrosis recurrence for the patients after four years for the first one of them. We think that the stem cells participate to the local control of inflammation. (N.C.)

  1. Effets thérapeutiques des cellules T regulatrices induitent par TGF-β sur l’autoimmunité et l’inflammation préétablies

    OpenAIRE

    Zheng, Song Guo

    2011-01-01

    Recent studies revealed that nTregs has less therapeutic effects on established autoimmune diseases. Current study asks if iTregs induced ex-vivo with TGF- can treat the established autoimmune diseases. In allergic asthma we observed that adoptive transfer of iTreg significantly suppressed airway and peri-vascular inflammation, reduced airway résistance, eosinophil recruitment, mucus hyper-production, airway remodeling and IgE levels. This therapeutic effect was associated with increase of Tr...

  2. Realisation and characterization of organic photovoltaic cells obtained by physical vapor deposition; Realisation et caracterisation de cellules photovoltaiques organiques obtenues par depot physique

    Energy Technology Data Exchange (ETDEWEB)

    Brousse, B.

    2004-12-01

    This work deals with the synthesis and the characterization of low cost organic solar cells, contributing to the development of renewable energies, and able to feed devices as portable telephone...In particular, we have contributed to the development of an experimentation bench for the obtention of different structures (bilayers, interpenetrated and multilayers) of solar cells from different donor-acceptor couples of small molecules. After having presented a retrospective of the physical phenomena and of the mechanisms involved, as well as those of the photovoltaic principle in the organic materials, we describe the technological steps allowing to carry out the solar cells. The materials (organic and metallic) are deposited on thin films (of 30 to 100 nm) spin-coating (PEDOT-PSS) or by vacuum evaporation (small molecules and metallization of the cathode) on a glass substrate covered by a conducting and a semi-transparent ITO layer constituting the anode. The structures carried out have been characterized in air in obscurity and under illumination by curves I(V), by capacitive measurements and IPCE spectra (photocurrent spectra). Different donor-acceptor couples (phthalocyanine/C60, oligomer of thiophene/C60 and phthalocyanine/perylene derivative) have been tested by various configurations: p-n heterojunctions distributed or not in the volume. The obtained results are better for the bilayers structures on account of the granularity of the C60. This characteristics have allowed us to carry out an efficient multilayer structure (CuPc/C60). In order to resolve the problem of the deposit of the C60, we have tested another acceptor molecule: a derived compound of the perylene (PPTC). Complementary studies have been carried out by the ionic implantation of the active layers, allowing both a densification and a doping of these ones; the encapsulation of the compounds by polyimide VDP (gaseous phase polymerization) have been evaluated. With this technique, we have developed too an alternative auto-protected structure. (O.M.)

  3. Designing Tone Reservation PAR Reduction

    Directory of Open Access Journals (Sweden)

    Johansson Albin

    2006-01-01

    Full Text Available Tone reservation peak-to-average (PAR ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.

  4. ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes

    OpenAIRE

    Lioy, Virginia S.; Andrea Volante; Nora E Soberón; Rudi Lurz; Silvia Ayora; Alonso, Juan C.

    2015-01-01

    In Firmicutes, small homodimeric ParA-like (δ2) and ParB-like (ω2) proteins, in concert with cis-acting plasmid-borne parS and the host chromosome, secure stable plasmid inheritance in a growing bacterial population. This study shows that (ω:YFP)2 binding to parS facilitates plasmid clustering in the cytosol. (δ:GFP)2 requires ATP binding but not hydrolysis to localize onto the cell's nucleoid as a fluorescent cloud. The interaction of (δ:CFP)2 or δ2 bound to the nucleoid with (ω:YFP)2 foci f...

  5. Submandibular cellulitis (Ludwig's angina) associated to a complex odontoma erupted into the oral cavity. Case report and literature review.

    Science.gov (United States)

    Bertolai, R; Acocella, A; Sacco, R; Agostini, T

    2007-01-01

    The clinical presentation of Ludwig's angina consists in a severe expanding cellulitis causing swelling of the floor of the mouth, tongue and submandibular region, thus resulting in a possible obstruction of the airway and in a rapid progress in deep neck soft tissue infection and mediastinitis with potentially fatal consequences. Frequently, submandibular cellulitis develops from an acute infection spreading from the lower molar teeth. Mandibular fractures, traumatic laceration of the floor of the mouth, and peritonsillar abscesses are other concomitant clinical features. A case of Ludwig's angina associated with a large erupted odontoma and with a deeply impacted third molar displaced to the border of the mandible is described. The patient was affected by enlargement of submandibular space, marked face swelling causing an evident face deformity, tenderness and redness of the neck and limited movement of the neck and mouth. In the past, Ludwig's angina was frequently fatal, however aggressive surgical and medical therapy have significantly reduced the mortality rate. The reported case can be considered as important, not only because of the rarity of the odontoma eruption in the oral cavity, but mainly for the extent of the clinical manifestation of a lesion usually described in literature as asymptomatic.

  6. Cutaneous Richter Syndrome mimicking a lower limb cellulitis infection - a case report and review of the literature.

    Science.gov (United States)

    César, Artur; Calistru, Ana; Pardal, Joana; Magina, Sofia; Mota, Alberto; Azevedo, Filomena

    2016-01-01

    Richter syndrome (RS) is characterized by the development of a high-grade lymphoma in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Herein, we present the case of an 85-year-old woman with a 3-year history of stable asymptomatic CLL that developed a cutaneous RS. The patient presented with painless inflammation in the left leg and foot that was initially diagnosed as a cellulitis infection. She was treated accordingly with ceftriaxone and clindamycin. However, after completing the antibiotic regimen, not only did the inflammation persist, but also superimposed painless nodules gradually appeared on the left leg and foot over the course of four months. The histopathological examination of the nodules revealed a large B-cell cutaneous lymphoma. The patient underwent chemotherapy with CVP, followed by R-CHOP, resulting in a reduction of size of the nodules and remission of the inflammation. The patient died five months after the diagnosis owing to a bacterial pneumonia. We identified in previous reports a total of fifteen cases of cutaneous RS. Most cases presented with rapidly growing tumors or multiple erythematous nodules, similar to our case. This case of a cutaneous RS mimicking a cellulitis infection underlines the importance of a low threshold for performing biopsies of suspicious skin lesions in patients with CLL/SLL. PMID:27617524

  7. Ultrahigh-rate supercapacitors with large capacitance based on edge oriented graphene coated carbonized cellulous paper as flexible freestanding electrodes

    Science.gov (United States)

    Ren, Guofeng; Li, Shiqi; Fan, Zhao-Xia; Hoque, Md Nadim Ferdous; Fan, Zhaoyang

    2016-09-01

    Large-capacitance and ultrahigh-rate electrochemical supercapacitors (UECs) with frequency response up to kilohertz (kHz) range are reported using light, thin, and flexible freestanding electrodes. The electrode is formed by perpendicularly edge oriented multilayer graphene/thin-graphite (EOG) sheets grown radially around individual fibers in carbonized cellulous paper (CCP), with cellulous carbonization and EOG deposition implemented in one step. The resulted ∼10 μm thick EOG/CCP electrode is light and flexible. The oriented porous structure of EOG with large surface area, in conjunction with high conductivity of the electrode, ensures ultrahigh-rate performance of the fabricated cells, with large areal capacitance of 0.59 mF cm-2 and 0.53 mF cm-2 and large phase angle of -83° and -80° at 120 Hz and 1 kHz, respectively. Particularly, the hierarchical EOG/CCP sheet structure allows multiple sheets stacked together for thick electrodes with almost linearly increased areal capacitance while maintaining the volumetric capacitance nearly no degradation, a critical merit for developing practical faraday-scale UECs. 3-layers of EOG/CCP electrode achieved an areal capacitance of 1.5 mF cm-2 and 1.4 mF cm-2 at 120 Hz and 1 kHz, respectively. This demonstration moves a step closer to the goal of bridging the frequency/capacitance gap between supercapacitors and electrolytic capacitors.

  8. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  9. Contribution à l'étude des perturbations électromagnétiques générées par des convertisseurs

    OpenAIRE

    Lardellier, Maurice

    1996-01-01

    Ce travail présente une nouvelle méthode de détermination des perturbations conduites générées par les convertisseurs statiques à plusieurs cellules de commutation. Cette méthode permet de faciliter la prise en compte des contraintes de Compatibilité Electromagnétique le plus tôt possible lors de la conception. La méthode proposée consiste en une étude conjointe des perturbations conduites en mode commun et en mode différentiel, en décomposant les circuits en blocs élémentaires, puis en super...

  10. ParB spreading requires DNA bridging

    OpenAIRE

    Graham, Thomas G. W.; Wang, Xindan; Song, Dan; Etson, Candice M.; van Oijen, Antoine M.; Rudner, David Z.; Loparo, Joseph J.

    2014-01-01

    The bacterial parABS system is employed for plasmid partitioning and chromosome segregation. ParB binds to parS sites and associates with broad regions of adjacent DNA, a phenomenon known as spreading. However, the molecular basis for spreading is unknown. Using single-molecule approaches, Graham et al. demonstrate DNA bridging by B. subtilis ParB (Spo0J). Spo0J mutations that disrupt DNA bridging lead to defective spreading and SMC condensin complex recruitment. This study suggests a novel, ...

  11. Cellulitis-like symptoms manifested by bone metastasis of lung cancer in a patient living with human immunodeficiency virus.

    Science.gov (United States)

    Kashima, Jumpei; Okuma, Yusuke; Watanabe, Kageaki; Ajisawa, Atushi; Hishima, Tsunekazu

    2016-09-01

    Human immunodeficiency virus (HIV)-infected patients are at a high risk of cancer compared with the general population. As the use of antiretroviral therapy (ART) has increased, non-AIDS-defining cancers have also increased in the past decade. A 61-year-old man with HIV infection on ART developed a painful, erythematous and oedematous lower left leg and an associated fever. He was initially treated with antibiotics for cellulitis but there was no improvement, which warranted further investigation. A translucent lesion was found by X-ray imaging and bone scintigraphy showed bone metastasis from a primary adenocarcinoma of the lung, documented by chest computed tomography and an axillary lymph node biopsy. The patient died three months after the diagnosis despite undergoing chemotherapy. This case demonstrates that physicians should consider metastatic malignancies as a differential diagnoses for diverse skin changes in HIV-infected patients. PMID:26404113

  12. Cellular therapy by mesenchymal stem cells in the gamma radiation-induced multi organ dysfunction syndrome; Therapie cellulaire par cellules souches mesenchymateuses d'une atteinte multi-organes induite par une irradiation gamma: un modele experimental

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Semont, A.; Frick, J.; Sache, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [Institut de Radioprotection et de Surete Nucleaire (IRSN), Direction de la Radioprotection de l' Homme, 92 6 Fontenay-aux-Roses (France); Gorin, N.C. [Universite Paris -6 Pierre et Marie Curie, Faculte de Medecine Saint-Antoine, Lab. de Therapie Cellulaire et Radioprotection Accidentelle, EA 1638, 75 - Paris (France); Hopital Saint-Antoine, Service d' Hematologie et de Therapie Cellulaire, 75 - Paris (France)

    2007-07-15

    Mesenchymal stem cells (M.S.C.) have been shown to migrate to various tissues. There is little information on the fate and potential therapeutic efficacy of the re infusion of M.S.C. following total body irradiation (T.B.I.). We addressed this question using human M.S.C. (h.M.S.C.) infused to non obese diabetic/severe combined immuno-deficient (N.O.D./S.C.I.D.) mice submitted to T.B.I.. Further, we tested the impact of additional local irradiation (A.L.I.) superimposed to T.B.I., as a model of accidental irradiation. N.O.D./S.C.I.D. mice were transplanted with h.M.S.C.. Group 1 was not irradiated before receiving h.M.S.C. infusion. Group 2 received only T.B.I. at a dose of 3.5 Gy, group 3 received local irradiation to the abdomen at a dose of 4.5 Gy in addition to T.B.I., and group 4 received local irradiation to the leg at 26.5 Gy in addition to T.B.I.. Fifteen days after gamma irradiation, quantitative and spatial distribution of the h.M.S.C. were studied. Histological analysis of mouse tissues confirmed the presence of radio-induced lesions in the irradiated fields. Following their infusion into nonirradiated animals, h.M.S.C. homed at a very low level to various tissues (lung, bone marrow, and muscles) and no significant engraftment was found in other organs. T.B.I. induced an increase of engraftment levels of h.M.S.C. in the brain, heart, bone marrow, and muscles. Abdominal irradiation (A.I.) as compared with leg irradiation (L.I.) increased h.M.S.C. engraftment in the exposed area (the gut, liver, and spleen). Comparison of two local irradiations has shown that (L.I.) as compared with (A.I.) increased h.M.S.C. engraftment in the exposed area. An increase of h.M.S.C. engraftment in organs outside the fields of the A.L.I. was also observed. Conversely, following L.I., h.M.S.C. engraftment was increased in the brain as compared with A.I.. This study shows that engraftment of h.M.S.C. in N.O.D./ S.C.I.D. mice with significantly increased in response to tissue injuries following T.B.I. with or without A.L.I.. A.L.I. induced an increase of the level of engraftment at sites outside the local irradiation field, thus suggesting a distant (abscopal) effect of radiation damage. This work supports the use of M.S.C. to repair damaged normal tissues following accidental irradiation and possibly in patients submitted to radiotherapy. (authors)

  13. ETUDE ET SIMULATION DE CELLULES PHOTOVOLTAIQUES A CONTACTS ARRIERES INTERDIGITÉS SOUS ENVIRONNEMENT SILVACO

    OpenAIRE

    MOHAMMEDI, Mohammed

    2012-01-01

    Ces dernières années un engouement particulier a été donné au remplacement des énergies fossiles et fissiles, épuisables, dangereuses et polluantes, par les énergies renouvelables et en particulier le solaire, propres et inépuisables. Grace à l’effet photovoltaïque la conversion de l’énergie solaire en électricité est possible. Depuis les années cinquante plusieurs travaux et élaborations des dispositifs photovoltaïques ont été élaborés. Les premiers travaux étaient destinés su...

  14. In situ Identifizierung und Charakterisierung endothelialer Progenitorzellen im bovinen Ovar

    OpenAIRE

    Schoen, Kornelia

    2016-01-01

    In the course of the reproductive cycle, ovaries are subject to considerable changes, which result in an abundant growth of blood vessels during the formation of the corpus luteum and the regression of blood vessels during luteolysis. The process of neovascularization comprises one third of the total length of the ovarian cycle and is more vigorous than in malignant tumors. The origin of these proliferating endothelial cells has not been completely clarified yet. The enclosed doctoral thesis ...

  15. Endotheliale Dysfunktion der Koronargefäße

    Directory of Open Access Journals (Sweden)

    Britten MB

    2003-01-01

    Full Text Available Die Integrität des Endothels ist essentiell für den Erhalt seiner antiatherosklerotischen Eigenschaften. Hierbei spielt die Balance zwischen dem vaskuloprotektiven NO und den ihm entgegenwirkenden Sauerstoffradikalen, wie Sauerstoffsuperoxid, eine zentrale Rolle (Redoxgleichgewicht. Ist diese Balance gestört, kommt es zur endothelialen Aktivierung mit weitreichender Beeinflussung des lokalen vaskulären Milieus. Proliferationsprozesse, Apoptose und die Aktivierung von Makrophagen und Metalloproteinasen führen zur Plaqueentstehung und schließlich zur Destabilisierung. Instabile Plaques erhöhen die Gefahr eines akuten Koronarsyndroms mit Ausbildung eines Myokardinfarkts und in der Folge dem Auftreten des plötzlichen Herztodes oder myokardialen Pumpversagens. Klinische Untersuchungen bestätigen die prognostische Tragweite der endothelialen Funktionsstörung. Dies wird auch durch die Tatsache unterstrichen, daß potente atheroprotektive Medikamente, wie ACE-Hemmer oder Statine, welche die Prognose von Patienten verbessern, auch mit einer Verbesserung der endothelialen Funktion assoziiert sind.

  16. Protection des ions organiques contre les dommages induits a l'ADN par les electrons de basse energie

    Science.gov (United States)

    Dumont, Ariane

    Il a ete demontre que les electrons de basse energie (EBE) peuvent induire des cassures simple brin (CSB) a l'ADN, via la formation d'anions transitoires qui decroissent par attachement dissociatif, ou dans d'autres etats electroniques dissociatifs menant a la fragmentation. Afin d'effectuer une etude complete des effets des electrons de basse energie sur la matiere biologique, il est necessaire de comprendre leur mecanismes d'interaction non seulement avec l'ADN, mais avec les constituants de son environnement. Les histones sont une composante importante de l'environnement moleculaire de l'ADN. Leur charge positive leur permet de s'associer aux groupements phosphate anionique de l'ADN. Le role principal de ces proteines basiques consiste a organiser l'ADN et l'empaqueter afin de former la chromatine. Les cations sont une autre composante importante de la cellule; ils jouent un role dans la stabilisation de la conformation B de l'ADN in vitro par leurs interactions avec les petits et grands sillons de l'ADN, ainsi qu'avec le groupement phosphate charge negativement. Avec les histones, ils participent egalement a la compaction de l'ADN pour former la chromatine. Cette etude a pour but de comprendre comment la presence d'ions organiques (sous forme de Tris et d'EDTA) a proximite de l'ADN modifie le rendement de cassures simple brin induit par les electrons de basse energie. Le Tris et l'EDTA ont-ete choisis comme objet d'etude, puisqu'en solution, ils forment le tampon standard pour solubiliser l'ADN dans les experiences in vitro (10mM Tris, 1mM EDTA). De plus, la molecule Tris possede un groupement amine alors que l'EDTA possede 4 groupements carboxyliques. Ensembles, ils peuvent se comporter comme un modele simple pour les acides amines. Le ratio molaire de 10 :1 de Tris par rapport a l'EDTA a pour but d'imiter le comportement des histones qui sont riches en arginine et lysine, acides amines possedant un groupement amine charge positivement additionnel. Des films d

  17. Economic evaluation of linezolid, flucloxacillin and vancomycin in the empirical treatment of cellulitis in UK hospitals: a decision analytical model.

    Science.gov (United States)

    Vinken, A; Li, Z; Balan, D; Rittenhouse, B; Wilike, R; Nathwani, D

    2001-12-01

    Standard antibiotic treatment of infections has become more difficult and costly due to treatment failure associated with the rise in bacterial resistance. New antibiotics that can overcome such resistant pathogens have the potential for great clinical and economic impact. Linezolid is a new antibiotic that is effective in the treatment of both antibiotic-susceptible and antibiotic-resistant Gram-positive bacterial infections, including those resistant to other available antibiotics. This breadth of activity is unique in existing antibiotics for Gram-positive bacteria and serves as the rationale for exploring the hypothesis that linezolid is an appropriate choice when considering empirical treatment of cellulitis in complicated or compromised patients in the nosocomial setting. A decision-modelling approach was used to compare the predicted first-line treatment efficacy and direct medical costs of linezolid with standard treatment of cellulitis among hospitalized patients. For the purposes of this analysis, standard care is defined along two main pathways: (1) initiating care with intravenous (iv) flucloxacillin, switching to vancomycin if the pathogen is found to be resistant to flucloxacillin, or maintaining flucloxacillin if the pathogen is found susceptible, or when culture and sensitivity analysis is inconclusive; or (2) initiating care with vancomycin, switching to iv flucloxacillin if the pathogen is found susceptible to flucloxacillin, maintaining vancomycin if the infection is found resistant, or when culture and sensitivity are inconclusive. For those patients taking iv flucloxacillin, a switch to oral flucloxacillin was allowed when clinically appropriate. We hypothesized that the cost of care of initiating treatment with linezolid would be less than that for both vancomycin and flucloxacillin in resistance risk ranges typically encountered in UK hospitals. In addition, while the registration trials showed equivalence of linezolid with the comparators in

  18. Performance testing of passive autocatalytic recombiners (PARs)

    Energy Technology Data Exchange (ETDEWEB)

    Blanchat, T. [Sandia National Laboratories, Albuquerque, NM (United States); Malliakos, A. [U.S. Nuclear Regulatory Commission, Washington, DC (United States)

    1997-03-01

    Passive autocatalytic recombiners (PARs) have been under consideration in the U.S. as a combustible gas control system in advanced light water reactor (ALWR) containments for design basis and severe accidents. PARs do not require a source of power. Instead they use palladium or platinum as a catalyst to recombine hydrogen and oxygen gases into water vapor upon contact with the catalyst. Energy from the recombination of hydrogen with oxygen is released at a relatively slow but continuous rate into the containment which prevents the pressure from becoming too high. The heat produced creates strong buoyancy effects which increases the influx of the surrounding gases to the recombiner. These natural convective flow currents promote mixing of combustible gases in the containment. PARs are self-starting and self-feeding under a very wide range of conditions. The recombination rate of the PAR system needs to be great enough to keep the concentration of hydrogen (or oxygen) below acceptable limits. There are several catalytic recombiner concepts under development worldwide. The USNRC is evaluating a specific design of a PAR which is in an advanced stage of engineering development and has been proposed for ALWR designs. Sandia National laboratories (SNL), under the sponsorship and the direction of the USNRC, is conducting an experimental program to evaluate the performance of PARs. The PAR will be tested at the SURTSEY facility at SNL. The test plan currently includes the following experiments: experiments will be conducted to define the startup characteristics of PARs (i.e., to define what is the lowest hydrogen concentration that the PAR starts recombining the hydrogen with oxygen); experiments will be used to define the hydrogen depletion rate of PARs as a function of hydrogen concentration; and experiments will be used to define the PAR performance in the presence of high concentrations of steam. (author)

  19. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  20. Hypothesis of Lithocoding: Origin of the Genetic Code as a "Double Jigsaw Puzzle" of Nucleobase-Containing Molecules and Amino Acids Assembled by Sequential Filling of Apatite Mineral Cellules.

    Science.gov (United States)

    Skoblikow, Nikolai E; Zimin, Andrei A

    2016-05-01

    The hypothesis of direct coding, assuming the direct contact of pairs of coding molecules with amino acid side chains in hollow unit cells (cellules) of a regular crystal-structure mineral is proposed. The coding nucleobase-containing molecules in each cellule (named "lithocodon") partially shield each other; the remaining free space determines the stereochemical character of the filling side chain. Apatite-group minerals are considered as the most preferable for this type of coding (named "lithocoding"). A scheme of the cellule with certain stereometric parameters, providing for the isomeric selection of contacting molecules is proposed. We modelled the filling of cellules with molecules involved in direct coding, with the possibility of coding by their single combination for a group of stereochemically similar amino acids. The regular ordered arrangement of cellules enables the polymerization of amino acids and nucleobase-containing molecules in the same direction (named "lithotranslation") preventing the shift of coding. A table of the presumed "LithoCode" (possible and optimal lithocodon assignments for abiogenically synthesized α-amino acids involved in lithocoding and lithotranslation) is proposed. The magmatic nature of the mineral, abiogenic synthesis of organic molecules and polymerization events are considered within the framework of the proposed "volcanic scenario". PMID:27048216

  1. Étude de transfert des films minces de silicium monocristallin dans la réalisation de cellule solaire à faible budget thermique

    OpenAIRE

    BENCHERRAT, Abdennebi

    2012-01-01

    La production de l‟électricité à partir de l‟énergie solaire est devenue très importante ce qui conduit à développer les cellules photovoltaïques et améliorer leurs rendements. Le silicium est le matériau le plus largement utilisé pour la conversion photovoltaïque. Cependant, le coût du silicium constitue près de 50 % du prix de revient d'un module photovoltaïque. La réduction de consommation de matériau silicium est une solution très importante.

  2. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  3. Films minces à base de Si nanostructuré pour des cellules photovoltaïques de 3ème génération.

    OpenAIRE

    Nalini, R.P.

    2012-01-01

    L'association du concept de troisième génération de cellules solaires et de la technologie de fabrication des films minces ouvre la voie à l'élaboration de matériaux entrant dans le cadre des énergies renouvelables. Les effets de confinement quantiques observés dans les nanostructures de silicium sont exploités pour une intégration dans des dispositifs du type cellule tandem tout-silicium. Cette thèse vise à comprendre la formation de nanoparticules de silicium dans deux types de ...

  4. Radio-vulcanization of natural rubber in the latex phase. Study of an experimental 1 tonne per hour production; Radio-vulcanisation du caoutchouc naturel en phase latex. Etude d'une production experimentale de 1 tonne par heure

    Energy Technology Data Exchange (ETDEWEB)

    Leveque, P.; Puig, J.R.; Roudeix, H. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    After briefly reviewing the main research carried out on the radio-vulcanization of latex and elastomers, a description is given of 4 types of cell which have been used successively with a view to industrial irradiation. They have made it possible to acquire the information necessary for resolving the main problem arising during irradiation - the formation of coagulum. The first two cell are designed for irradiation by a horizontal beam ('Dynamitron'), the two others use a vertical beam ('Circe'). The study of the properties of the rubber obtained shows it to compare favorably with 'Revultex'. In the appendix are given some characteristics of natural latex and information about its processing. (authors) [French] Apres un rappel des principales etudes sur la radio-vulcanisation du latex et des elastomeres, on decrit les quatre types de cellules successivement essayes en vue de l'irradiation industrielle. Ils ont permis d'acquerir les informations necessaires a la resolution du probleme principal pose par l'irradiation, la formation de coagulum au cours de celle,-ci. Les deux premiers sont concus pour l'irradiation par un faisceau horizontal ('Dynamitron'), les derniers par un faisceau vertical ('Circe'). L'etude des proprietes du caoutchouc obtenu montre qu'il se compare favorablement au 'Revultex'. Un apercu est donne en annexe des caracteristiques du latex naturel et de sa mise en oeuvre. (auteurs)

  5. The Expression of the Thrombin Receptors PAR-3 and PAR-4 is Downregulated in Pancreatic Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Claudia Rudroff

    2015-05-01

    Full Text Available Background: Patients with pancreatic cancer frequently suffer from thrombosis as a consequence of excess thrombin generation. In addition to its role in the plasmatic coagulation cascade, thrombin induces numerous cellular effects by activating a unique group of G-protein-coupled receptors on the cell membrane, the proteinase-activated receptors (PARs. At present, PAR-1, PAR-3 and PAR-4 are known to be activated by thrombin. We previously demonstrated a putative role for PAR-1 in pancreatic cancer progression, but little is known about the physiological and pathophysiological roles of PAR-3 and PAR-4. In the present study, we examined the expression patterns of PAR-3 and PAR-4 in pancreatic tissue and pancreatic cancer cells. Methods: Tissue samples from three patients with pancreatic adenocarcinoma and six human pancreatic carcinoma cell lines were examined. Gene expression was analysed by RT-PCR and quantified by HPLC. Protein expression was determined by Western blot analysis. Data analysis was performed using ANOVA in SPSS. Results and Conclusion: In contrast to PAR-1, both PAR-3 and PAR-4 were expressed in healthy pancreases but downregulated in pancreatic cancer. The contrasting expression patterns of PAR-3 and PAR-4 compared with PAR-1 indicate that the mechanism that regulates the cellular effects of thrombin on tumor progression remains to be fully elucidated.

  6. Traitement des eaux par électrofloculation

    OpenAIRE

    Cansado, Isabel

    1997-01-01

    Traitement des eaux par electrofloculation Les écosystèmes aquatiques sont très affectés par les eaux de rejet qui sont déversées dans les cours d’eau. La charge de ces eaux existe sous diverses formes: solutés, colloïdes ou particules. Il est important de traiter l’eau usée à de faibles coûts au lieu de la rejeter directement dans le milieu récepeteur. Dans le but d’améliorer les procédés physico-chimiques de déstabilisation des émulsions, nous étudions les traitements par électrocoagulat...

  7. Programmation par contraintes avec des fourmis

    OpenAIRE

    Khichane, Madjid; Albert, Patrick; Solnon, Christine

    2008-01-01

    National audience On explore dans cet article les possibilités d'intégration de la métaheuristique d'optimisation par colonies de fourmis (ACO) dans un langage de programmation par contraintes (PPC). L'idée est d'utiliser un langage de PPC pour décrire le problème à résoudre, ainsi que pour propager et vérifier les contraintes, et d'utiliser ACO pour guider la recherche de solutions. On illustre notre approche sur le problème d'ordonnancement de voitures.

  8. SWANN ORGANIQUE (EN PASSANT PAR BECKETT PANOPTIQUE

    Directory of Open Access Journals (Sweden)

    Sjef Houppermans

    2013-12-01

    Full Text Available Comme quoi Swann a bel et bien un corps souffrant et jouissant. Comme quoi Swann absorbe le monde surtout par ses six sens. Comme quoi l´univers de Swann est une aire de dissémination que Samuel Beckett sonde exemplairement dans son étude de 1930.

  9. Cellulitis and Erysipelas

    Science.gov (United States)

    ... long-term) swelling of your arms or legs (lymphedema). Diagnosis Your healthcare provider may take a sample or culture from your skin lesions to identify the bacteria causing infection. He or she may also recover the bacteria from your blood. Treatment Depending on how severe the infection is, your ...

  10. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    International Nuclear Information System (INIS)

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  11. A combined global and local approach to elucidate spatial organization of the Mycobacterial ParB-parS partition assembly.

    Science.gov (United States)

    Chaudhuri, Barnali N; Gupta, Sayan; Urban, Volker S; Chance, Mark R; D'Mello, Rhijuta; Smith, Lauren; Lyons, Kelly; Gee, Jessica

    2011-03-22

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  12. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition Assembly

    Energy Technology Data Exchange (ETDEWEB)

    B Chaudhuri; S Gupta; V Urban; M Chance; R DMello; L Smith; K Lyons; J Gee

    2011-12-31

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  13. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhuri, Barnali [University of Buffalo, The State University of New York; Gupta, Sayan [Case Western Reserve University; Urban, Volker S [ORNL; Chance, Mark [Case Western Reserve University; D' Mello, Rhijuta [Case Western Reserve University; Smith, Lauren [University of Buffalo, The State University of New York; Lyons, Kelly [University of Buffalo, The State University of New York; Gee, Jessica [University of Buffalo, The State University of New York

    2010-01-01

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  14. Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

    Directory of Open Access Journals (Sweden)

    Ledina Dragan

    2012-11-01

    Full Text Available Abstract Introduction Campylobacter is an important causative agent of intestinal infections in humans. Bacteremia is detected in less than 1% of patients, mainly in immunocompromised patients and in extreme age groups. Cellulitis is a relatively common manifestation of Campylobacter infection, but concomitant bacteremia is a rare event. Infections of the pacemaker area are caused primarily by staphylococci, followed by fungi, streptococci and Gram-negative rods. To the best of our knowledge, this is the first case report of pacemaker pocket infection and bacteremia caused by Campylobacter fetus. Case presentation A 72-year-old Croatian Caucasian man with myelodysplasia, impaired fasting glucose levels and a recently implanted permanent pacemaker was admitted to hospital after six days of fever, development of red swelling of the pacemaker pocket area and worsening of his general condition. No antibiotic therapy was introduced in the outpatient setting. He denied any recent gastrointestinal disturbances. With the exception of an elevated leukocyte count, erythrocyte sedimentation rate, and C-reactive protein and blood glucose levels, other laboratory findings were normal. Treatment with vancomycin plus netilmicin was introduced, and a surgical incision with drainage of the pacemaker pocket was performed. The entire pacemaker system was removed and a new one re-implanted after 14 days of antibiotic therapy. Transesophageal echocardiography showed no pathological findings. Three subsequent blood cultures obtained on admission as well as swab culture of the incised pacemaker area revealed Campylobacter fetus; stool and pacemaker lead cultures were negative. According to the microbiological results, antibiotic therapy was changed to ciprofloxacin plus netilmicin. A clinical examination and the results of a laboratory analysis performed after two weeks of therapy were within normal limits. Conclusion Myelodysplasia, impaired fasting glucose levels

  15. Microscopie par rayons X dans la fenêtre de l'eau : faisabilité et intérêt pour la biologie d'un instrument de laboratoire

    Science.gov (United States)

    Adam, J. F.; Moy, J. P.

    2005-06-01

    La biologie étudie des structures ou des phénomènes sub-cellulaires. Pour cela la microscopie est la technique d'observation privilégiée. La résolution spatiale de la microscopie optique s'avère bien souvent insuffisante pour de telles observations. Les techniques plus résolvantes, comme la microscopie électronique par transmission sont souvent destructrices et d'une complexité peu adaptée aux besoins des biologistes. La microscopie par rayons X dans la fenêtre de l'eau permet l'imagerie rapide de cellules dans leur milieu naturel, nécessite peu de préparation et offre des résolutions de quelques dizaines de nanomètres. De plus, il existe un bon contraste naturel entre les structures carbonées (protéines, lipides) et l'eau. Actuellement cette technique est limitée aux centres de rayonnement synchrotron, ce qui impose une planification et des déplacements incompatibles avec les besoins de la biologie. Un tel microscope fonctionnant avec uns source de laboratoire serait d'une grande utilité. Ce document présente un état de l'art de la microscopie par rayons X dans la fenêtre de l'eau. Un cahier des charges détaillé pour un appareil de laboratoire ayant les performances optiques requises par les biologistes est présenté et confronté aux microscopes X de laboratoire déjà existants. Des solutions concernant la source et les optiques sont également discutées.

  16. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  17. Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells

    DEFF Research Database (Denmark)

    Albrektsen, T; Sørensen, B B; Hjortø, G M;

    2007-01-01

    Out of 8500 genes, FVIIa stimulation induced differential regulation of 39 genes most of which were not previously recognized as FVIIa regulated. All genes regulated by FVIIa were similarly regulated by a PAR2 agonist peptide confirming FVIIa signaling via PAR2. An appreciable fraction of the PAR...

  18. Taare Zameen Par and dyslexic savants

    OpenAIRE

    Chakravarty, Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were pr...

  19. Combined DSEK and Transconjunctival Pars Plana Vitrectomy

    Directory of Open Access Journals (Sweden)

    Mona Sane

    2016-01-01

    Full Text Available We report here three patients who underwent combined Descemet’s stripping with endothelial keratoplasty and transconjunctival pars plana vitrectomy for bullous keratopathy and posterior segment pathology. A surgical technique and case histories are described. Anatomic and visual outcomes of combined Descemet’s stripping with endothelial keratoplasty and vitrectomy were excellent. Our experience provides technical guidelines and limitations. The combined minimally invasive techniques allow for rapid anatomical recovery and return of function and visual acuity in a single sitting.

  20. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas;

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  1. Recombination in the Human Pseudoautosomal Region PAR1

    OpenAIRE

    Anjali G Hinch; Nicolas Altemose; Nudrat Noor; Peter Donnelly; Simon R Myers

    2014-01-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this o...

  2. Characterisation in vivo of ways of induced deaths by p53, in the male germinal cells; Caracterisation in vivo des voies de mort induites par la p53, dans les cellules germinales males

    Energy Technology Data Exchange (ETDEWEB)

    Coureuil, M

    2006-10-15

    The male germinal cells constitute a heterogeneous cell population including pre-meiotic proliferating cells (spermatogonia) and meiotic cells and post meiotic cells in differentiation (spermatocytes and spermatids). We study the involvement in vivo of the p53 protein in the death of these cells with the help of two models, (1) a transgenic model of infertility, MTp53, in which the p53 is over expressed in the differentiated cells and induced their death, (2) the response of these cells to gamma irradiation, where only the spermatogonia die by apoptosis dependent of p53. We showed that the caspases (cysteine-aspartic proteases) are involved in the terminal differentiation of normal germinal cells. But in the MTp53 model, the p53 induces the death of differentiated cells via the activation of calpains and not of caspases. We studied the response of spermatogonia, to gamma irradiation by a transcriptomic approach, by DNA chips and semi-quantitative RT-PCR. we showed that the puma and dr5 genes are induced by the p53 after irradiation. more, the study of mice invalidated for trail ( the dr5 ligand) or for puma, allowed to demonstrate that the two effectors are essential to the activation of intrinsic and extrinsic ways of apoptosis. (N.C.)

  3. Cellules électrochimiques produisant du gaz : suivi de l'électrolyse par émission acoustique et effets de la mouillabilité des électrodes sur le flux des charges électriques

    OpenAIRE

    Brussieux, Charles

    2011-01-01

    Molten salts electrochemical processes, like fluorine and aluminium production processes produce bubbles on electrodes slightly wetted by an electrolyte. In those cells, the electrolyte convection is mainly induced by the motion of bubbles. Then, the residence time of gas is not under control and the modelling of such electrolysis still faces many challenges. This work begins with a collection of the information required to model gas-producing cells. We developed an electrochemical composite ...

  4. Aggressive large cell lymphoma: early assessment of therapeutic efficacy by positron emission tomography; Lymphome agressif a grandes cellules: appreciation precoce de l'efficacite therapeutique par la TEP au [{sup 18}F]-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Itti, E.; Maignan, M. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Medecine Nucleaire, 94 - Creteil (France); Haioun, C.; Reyes, F. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service d' Hematologie Clinique, 94 - Creteil (France); Rahmouni, A. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Radiologie, 94 - Creteil (France)

    2004-07-01

    The international prognostic index is a well-established tool for stratifying patients with aggressive non-Hodgkin's lymphoma scheduled for tailored therapy. Early FDG-PET imaging could play a major predictive role for patient survival by providing functional information about lymphoma chemo-sensitivity. We present here the results of the interim analysis (about SD patients) of a prospective multi-centre study (national PHRC), the goals of which were to correlate PET response after 2 induction cycles 1) to the therapeutic response assessed by conventional diagnostic methods and 2) to event free survival and global survival. (author)

  5. L'oxyde de zinc par dépôt chimique en phase vapeur comme contact électrique transparent et diffuseur de lumière pour les cellules solaires

    OpenAIRE

    Faÿ, Sylvie

    2003-01-01

    Zinc oxide (ZnO) is a material that belongs to the family of Transparent Conductives Oxides (TCO). Its non-toxicity and the abundant availability in the Earth's crust of its components make it an ideal candidate as electrical transparent contact for thin-film amorphous and/or microcrystalline silicon solar cells. The Low-Pressure Chemical Vapour Deposition (LP-CVD) method allows one to obtain rough ZnO layers, which can effectively scatter the light that passes through them. This high scatter...

  6. L'oxyde de zinc par dépôt chimique en phase vapeur comme contact électrique transparent et diffuseur de lumière pour les cellules solaires

    OpenAIRE

    Faÿ, Sylvie; Shah, Arvind V.

    2005-01-01

    Zinc oxide (ZnO) is a material that belongs to the family of Transparent Conductives Oxides (TCO). Its non-toxicity and the abundant availability in the Earth’s crust of its components make it an ideal candidate as electrical transparent contact for thin-film amorphous and/or microcrystalline silicon solar cells. The Low-Pressure Chemical Vapour Deposition (LP-CVD) method allows one to obtain rough ZnO layers, which can effectively scatter the light that passes through them. This high scatter...

  7. Study and fabrication of solid oxide fuel cells through tape casting and co-sintering; Etude et realisation par coulage en bande et co-frittage de cellules de pile a combustible a oxydes solides

    Energy Technology Data Exchange (ETDEWEB)

    Grosjean, A

    2004-11-15

    This work is dedicated to the devising of a low-cost fabrication process of solid oxide fuel cells (SOFC). Technical requirements impose the shaping method: stripe casting as well as the materials used: Yttria-stabilized zirconia (YSZ), nickel and lanthanum manganite doped with strontium (LSM). In order to comply with environmental requirements the developed process uses an aqueous barbotine solvent. We get electrodes and the electrolyte separately, the use of an absorbent drying process has enabled us to join 3 layers to form an elementary cell with great interfacial homogeneity. The resistance of the cell to sintering has been improved through the symmetrization of the deformations of the cell. In order to interpret the low electrical properties of the cell and its quick damaging, transmission microscopy studies have been performed. These studies have shown 2 facts. First, 2 isolating phases appear at the cathode (at the LSM/YSZ interface) because of a too high sintering temperature and secondly, a quick clustering of nickel grains appears during cell operation that leads to a local loss of the nickel grid percolation. This problem has been solved by increasing the size of nickel oxide grains from 0.5 {mu}m to 3 {mu}m) to stabilize the microstructure. The issue of the reactivity at the LSM/YSZ interfaces was tackled in 2 different ways, we have tried to lower the sintering temperature by using a zirconia nano-powder first and then by replacing zirconia in the electrolyte by gadolinium-doped ceria. The use of zirconia nano-powder has failed to decrease sintering temperature while preserving the electrolyte density and the use of ceria has triggered instabilities that have not yet been solved. Despite all these drawbacks, this process allows the fabrication of an excellent anode/electrolyte interface. (A.C.)

  8. Structural analysis of the ParR/parC plasmid partition complex

    DEFF Research Database (Denmark)

    Møller-Jensen, Jakob; Ringgaard, Simon; Mercogliano, Christopher P;

    2007-01-01

    Accurate DNA partition at cell division is vital to all living organisms. In bacteria, this process can involve partition loci, which are found on both chromosomes and plasmids. The initial step in Escherichia coli plasmid R1 partition involves the formation of a partition complex between the DNA....... coli plasmid pB171. ParR forms a tight dimer resembling a large family of dimeric ribbon-helix-helix (RHH)2 site-specific DNA-binding proteins. Crystallographic and electron microscopic data further indicate that ParR dimers assemble into a helix structure with DNA-binding sites facing outward. Genetic...

  9. Evaluation of the PAR corneal topography system

    Science.gov (United States)

    Jindal, Prateek; Cheung, Susan; Pirouzian, Amir; Keates, Richard H.; Ren, Qiushi

    1995-05-01

    The purpose of this study was to evaluate the raster photogrammetry based Corneal Topography System by determining: inter-operator variability, reproducibility of images, effects of defocused and decentered images, and the precision of data at different optical zones. 4 human cadaver eyes were used to study the inter-operator variability. To study the reproducibility of images, 3 human cadaver eyes and a test surface doped with flourescine (provided by PAR Vision Systems Corporation) were focused and their images taken four successive times. Defocused and decentered images were taken of 4 human cadaver eyes and four times of the test surface mentioned above. The precision of defocused/decentered cadaver eyes was evaluated at the following optical zones: 3 mm, 4 mm, 5 mm, and 6 mm. All human cadaver eyes used in the above experiments had their epithelial layer removed before imaging. Average inter-operator variability was 0.06 D. In reproducibility attempts, there was an average deviation of 0.28 D for the human cadaver eyes and 0.04 D for the test surface. The defocused and decentered test surface gave an average deviation of 0.09 D. Defocused and decentered cadaver eyes resulted in an average deviation of 0.52 D, 0.37 D, 0.24 D, and 0.22 D at optical zones of 3 mm, 4 mm, 5 mm, and 6 mm, respectively. The imaging method employed by PAR Vision Systems Corporation virtually eliminates inter-operator variability. The PAR Corneal Topography System's clinical usefulness, however, could be improved by improving the reproducibility of images, decreasing the sensitivity to spatial alignment, and increasing accuracy over smaller optical zones.

  10. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  11. A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin Complex

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, Kevin M.; Crosson, Sean (UC)

    2010-05-06

    Toxin-antitoxin (TA) systems form a ubiquitous class of prokaryotic proteins with functional roles in plasmid inheritance, environmental stress response, and cell development. ParDE family TA systems are broadly conserved on plasmids and bacterial chromosomes and have been well characterized as genetic elements that promote stable plasmid inheritance. We present a crystal structure of a chromosomally encoded ParD-ParE complex from Caulobacter crescentus at 2.6 {angstrom} resolution. This TA system forms an {alpha}{sub 2}{beta}{sub 2} heterotetramer in the crystal and in solution. The toxin-antitoxin binding interface reveals extensive polar and hydrophobic contacts of ParD antitoxin helices with a conserved recognition and binding groove on the ParE toxin. A cross-species comparison of this complex structure with related toxin structures identified an antitoxin recognition and binding subdomain that is conserved between distantly related members of the RelE/ParE toxin superfamily despite a low level of overall primary sequence identity. We further demonstrate that ParD antitoxin is dimeric, stably folded, and largely helical when not bound to ParE toxin. Thus, the paradigmatic model in which antitoxin undergoes a disorder-to-order transition upon toxin binding does not apply to this chromosomal ParD-ParE TA system.

  12. Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis.

    Science.gov (United States)

    Asdourian, Maria S; Skolny, Melissa N; Brunelle, Cheryl; Seward, Cara E; Salama, Laura; Taghian, Alphonse G

    2016-09-01

    Precautionary recommendations conveyed to survivors of cancer by health-care practitioners to reduce the risk of breast cancer-related lymphoedema are indispensable aspects of clinical care, yet remain unsubstantiated by high-level scientific evidence. By reviewing the literature, we identified 31 original research articles that examined whether lifestyle-associated risk factors (air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and skin infections-eg, cellulitis) increase the risk of breast cancer-related lymphoedema. Among the few studies that lend support to precautionary guidelines, most provide low-level (levels 3-5) or inconclusive evidence of an association between lymphoedema and these risk factors, and only four level 2 studies show a significant association. Skin infections and previous infection or inflammation on the ipsilateral arm were among the most clearly defined and well established risk factors for lymphoedema. The paucity of high-level evidence and the conflicting nature of the existing literature make it difficult to establish definitive predictive factors for breast cancer-related lymphoedema, which could be a considerable source of patient distress and anxiety. Along with further research into these risk factors, continued discussion regarding modification of the guidelines and adoption of a risk-adjusted approach is needed. PMID:27599144

  13. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells w...

  14. Identification des gaz combustibles par capteur catalytique

    OpenAIRE

    Rose, Gérard

    1995-01-01

    L'explosimètre est un instrument destiné à prévenir le risque d'inflammation d'un mélange d'air et de gaz en informant de la présence du gaz par une alarme, et en délivrant une mesure qu'il exprime en pourcentage de la limite inférieure d'explosivité du mélange (LIE). Il répond à tous les gaz et vapeurs combustibles, mais il ne donne une mesure juste que pour un seul d'entre-eux : celui pour lequel il a été étalonné. Cet inconvénient est sans conséquence si l'utilisateur identifie le gaz, car...

  15. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations. PMID:20142854

  16. Taare Zameen Par and dyslexic savants

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar

    2009-01-01

    Full Text Available The film Taare Zameen Par (Stars upon the Ground portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ′disinhibits′ the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  17. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  18. Contribution a l'industrialisation du soudage par friction malaxage

    OpenAIRE

    Zimmer, Sandra

    2009-01-01

    Le soudage par friction malaxage, ou FSW, est un procédé de soudage à l'« état solide » permettant d'éviter certains problèmes rencontrés en soudage par fusion comme la fissuration à chaud ou la création de soufflures. La soudure est réalisée par l'action d'un outil à l'interface de deux pièces à souder. Celui-ci a pour rôle de malaxer et d'échauffer par frottement la matière. Le cordon est réalisé de proche en proche. Les efforts générés à l'interface outil/matière doivent être repris par la...

  19. Recombination in the human Pseudoautosomal region PAR1.

    Science.gov (United States)

    Hinch, Anjali G; Altemose, Nicolas; Noor, Nudrat; Donnelly, Peter; Myers, Simon R

    2014-07-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome. PMID:25033397

  20. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  1. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  2. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    over the nucleoid. ParB ribbon-helix-helix dimers bind cooperatively to direct repeats in parC1 and parC2. Using four different assays we obtain solid evidence that ParB can pair parC1- and parC2-encoding DNA fragments in vitro. Convincingly, electron microscopy revealed that ParB mediates binary...... pairing of parC fragments. In addition to binary complexes, ParB mediated the formation of higher order complexes consisting of several DNA fragments joined by ParB at centromere site parC. N-terminal truncated versions of ParB still possessing specific DNA binding activity were incompetent in pairing...

  3. Control of cleavage spindle orientation in Caenorhabditis elegans: The role of the genes par-2 and par-3

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, N.N.; Kirby, C.M.; Kemphues, K.J. [Cornell Univ., Ithaca, NY (United States)

    1995-02-01

    Polarized asymmetric divisions play important roles in the development of plants and animals. The first two embryonic cleavages of Caenorhabditis elegans provide an opportunity to study the mechanisms controlling polarized asymmetric divisions. The first cleavage is unequal, producing daughters with different sizes and fates. The daughter blastomeres divide with different orientations at the second cleavage; the anterior blastomere divides equally across the long axis of the egg, whereas the posterior blastomere divides unequally along the long axis. We report here the results of our analysis of the genes par-2 and par-3 with respect to their contribution to the polarity of these divisions. Strong loss-of-function mutations in both genes lead to an equal first cleavage and an altered second cleavage. Interestingly, the mutations exhibit striking gene-specific differences at the second cleavage. The par-2 mutations lead to transverse spindle orientations in both blastomeres, whereas par-3 mutations lead to longitudinal spindle orientations in both blastomeres. The spindle orientation defects correlate with defects in centrosome movements during both the first and the second cell cycle. Temperature shift experiments with par-2 (it5ts) indicate that the par-2(+) activity is not required after the two-cell stage. Analysis of double mutants shows that par-3 is epistatic to par-2. We propose a model wherein par-2(+) and par-3(+) act in concert during the first cell cycle to affect asymmetric modification of the cytoskeleton. This polar modification leads to different behaviors of centrosomes in the anterior and posterior and leads ultimately to blastomere-specific spindle orientations at the second cleavage. 44 refs., 5 figs., 5 tabs.

  4. Cells for the examination of irradiated plutonium fuel elements - two years operation - may 1961/may 1963 (1963); Cellules pour examen d'elements combustibles au plutonium irradies - deux ans d'exploitation - mai 1961/mai 1963 (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Valentin, A. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1963-07-01

    Within the framework of the 'Rapsodie' fast reactor program, prototype plutonium fuel elements are irradiated and then examined in an {alpha} {beta} {gamma} laboratory at Saclay. This laboratory consists of five in line cells and a lead enclosure microscope. Each cell contains an {alpha} sealed removable box 4 ft 3 in. high, 4 ft 11 in. wide and 5 ft 1 in. deep, fitted with one or two magnetic transmission indirect manipulators. The boxes are contained in an {beta} {gamma} shielded enclosure whose front face is constructed of cast iron panels 21-2/3 in. thick. Nitrogen circulating in a closed loop forms the atmosphere of the boxes. This laboratory is essentially intended for metallurgical research. The functions of the various cells are as follows: transferring and packing, cutting, density measurement and cathodic etching, storage and metallography. Work on radioactive materials began in April 1961. Operational incidents have always been of a material nature only. (author) [French] Dans le cadre du projet de reacteur rapide Rapsodie, des elements combustibles prototypes au plutonium sont, apres irradiation, examines a Saclay dans un laboratoire {alpha} {beta} {gamma}. Celui-ci comprend cinq cellules en ligne et une enceinte en plomb contenant un microscope telecommande. Chaque cellule est constituee d'un caisson etanche (1, 3 m x 1, 5 m x 1, 56m) equipee d'un ou deux manipulateurs indirects a transmissions magnetiques. Les caissons sont places, dans une enceinte {beta} {gamma} dont la face avant est formee de blocs en fonte ayant 55 cm d'epaisseur. L'atmosphere des caissons est de l'azote, circulant en circuit ferme. Ce laboratoire est destine essentiellement a des recherches metallurgiques. Les fonctions des differentes cellules sont: conditionnement et transferts, tronconnage, mesure de densite et polissage ionique, stockage, metallographie. Le travail sur materiaux radioactifs a commence en avril 1961. Les incidents d

  5. Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C

    OpenAIRE

    Blanchard, Géraldine; Siegrist, Claire-Anne

    2007-01-01

    "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugué contre le sérogroupe C fait partie du plan de vaccination de routine. Chez les enfants de moins d'une année, 3 doses de vaccin induisent une montée importante des anticorps bactéricides, mais qui ne persistent pas au-delà d'une année. Les cellules B mémoires, semblent essentielles pour protéger les jeunes enfants primo-immunisés comme nourrissons. Dans...

  6. Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C

    OpenAIRE

    Blanchard Rohner, Géraldine

    2006-01-01

    "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugué contre le sérogroupe C fait partie du plan de vaccination de routine. Chez les enfants de moins d'une année, 3 doses de vaccin induisent une montée importante des anticorps bactéricides, mais qui ne persistent pas au-delà d'une année. Les cellules B mémoires, semblent essentielles pour protéger les jeunes enfants primo-immunisés comme nourrissons. Dans...

  7. PAR elevation influence on hydrogen floor layer depth

    International Nuclear Information System (INIS)

    In order to circumvent problems associated with containment loads resulting from a possible hydrogen combustion, French containments for instance are equipped with passive autocatalytic recombiners (PAR). The aim of this safety device is to recombine hydrogen with oxygen in order to limit hydrogen concentration. Hence, PAR distribution within the containment is a key feature to limit the hydrogen risk. According with the PARIS benchmark scenario and boundary conditions therein (EU-FP6, SARNET project) a floor layer developed with low mass and thermal mixing processes. In this paper we illustrate the link between the PAR elevation and the floor layer depth. (author)

  8. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  9. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle;

    2015-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is released in response to inflammatory stimuli, and plasma levels are associated with long-term outcomes. The ischemia/reperfusion injury caused by cardiac arrest (CA) and resuscitation triggers an inflammatory response...... analysis shoved an AUC of 0.76 at 6 hours. In the subgroup of CA of cardiac cause, the AUC was 0.84. CONCLUSION: suPAR levels at 6 and 36 hours after CA were significantly higher in nonsurviving patients compared with survivors; however, the overlap in suPAR levels between the outcome groups...

  10. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

    Directory of Open Access Journals (Sweden)

    Dale Beverly A

    2010-10-01

    Full Text Available Abstract Background Protease-Activated Receptors (PARs, members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs, but the signaling pathways downstream of PAR activation in HOKs have not been clearly defined. In this study, we aimed to determine if PAR1- and PAR2-mediated signaling differs in the induction of innate immune markers CXCL3, CXCL5 and CCL20 via ERK, p38 and PI3K/Akt. Results Our data show the induction of innate immunity by PAR1 requires both p38 and ERK MAP kinases, while PAR2 prominently signals via p38. However, inhibition of PI3K enhances expression of innate immune markers predominantly via suppressing p38 phosphorylation signaled by PAR activation. Conclusion Our data indicate that proteases mediating PAR1 and PAR2 activation differentially signal via MAP kinase cascades. In addition, the production of chemokines induced by PAR1 and PAR2 is suppressed by PI3K/Akt, thus keeping the innate immune responses of HOK in balance. The results of our study provide a novel insight into signaling pathways involved in PAR activation.

  11. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene;

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...

  12. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine;

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models.......Degradation of proteins in the extracellular matrix is crucial for the multistep process of cancer invasion and metastasis. Compelling evidence has demonstrated the urokinase receptor (uPAR) and its cognate ligand, the urokinase plasminogen activator (uPA), to play critical roles in the concerted...

  13. Determination of PARs capacity for HMS in EU APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Do Hyun [KHNP CRI, Daejeon (Korea, Republic of)

    2012-10-15

    The Hydrogen Mitigation System (HMS) is designed to control combustible gas, mainly hydrogen gas (H2) inside containment within the acceptable limits by the Passive Autocatalytic Recombiner (PAR) with consideration of hydrogen generation during severe accidents. In EU APR1400 (European APR1400), a passive hydrogen control system which is composed of a number of PARs, is adopted for the mitigation of the hydrogen induced risks. For the design of the HMS, the expected ranges for the global and local hydrogen concentrations in the containment and the increase rate of the concentrations should be examined to specify the required capacity and locations of the PARs. This paper describes the determination of PARs capacity for HMS in EU APR1400.

  14. A turquesa de Itacupim, Pará

    Directory of Open Access Journals (Sweden)

    Marcondes Lima da Costa

    2004-12-01

    Full Text Available Na ilha de Itacupim, localizada na região costeira do nordeste do Pará, foram encontrados veios de fosfatos de alumínio contendo turquesa, além de quartzo e argilominerais. A ilha é sustentada por espesso perfil laterítico maturo desenvolvido sobre complexo alcalino-ultramáfico mineralizado em apatita. Os veios e vênulas são de espessura centimétrica, normalmente constituídos de wavellita fibro-radial, onde pode ser observada turquesa verde-azulada, em massas subesferolíticas, microcristalinas, intercrescidas com caulinita e oxi-hidróxidos de Mn, além de quartzo. A identificação mineral foi realizada por DRX, microscopia óptica, análises químicas de rocha total, MEV/SED. Os teores de CuO são inferiores aos das turquesas em geral, compensados por Fe2O3 e ZnO. Os subesferolitos de turquesa contêm inúmeras inclusões micrométricas de goyazita ou svanbergita. A ocorrência da turquesa, na forma de veios e vênulas, seu aspecto porcelanado e a conhecida relação desse mineral com ambiente hidrotermal sugerem que a turquesa de Itacupim também seja de origem hidrotermal, reforçada pela sua associação com wavellita, goyazita ou svanbergita, quartzo e argilominerais. Ela não foi encontrada no perfil laterítico. Seu aspecto compacto e sua cor esverdeada abrem perspectivas para seu uso como mineral de gema.Veins and veinlets of aluminum phosphates with turquoise occur at the Itacupim Island in the coastal plain northeast the state of Pará. A thick mature lateritic iron crust rich in aluminum phosphates developed an apatite-bearing alkaline-ultramafic complex which constitutes the Island. The veins and veinlets are cm-thick, usually constituted by wavellite, fibrous to radialfibrous, with bony or porcelaneous aspect, and can turquoise. Pebbles of these phosphates inside of apatite-bearing ultramafic rocks are very common at the base of the hang wall, and locally form expressive agglomerates. Turquoise forms half spheroids and

  15. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  16. Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin.

    Science.gov (United States)

    Sviripa, Vitaliy M; Burikhanov, Ravshan; Obiero, Josiah M; Yuan, Yaxia; Nickell, Justin R; Dwoskin, Linda P; Zhan, Chang-Guo; Liu, Chunming; Tsodikov, Oleg V; Rangnekar, Vivek M; Watt, David S

    2016-01-01

    Advanced prostate tumors usually metastasize to the lung, bone, and other vital tissues and are resistant to conventional therapy. Prostate apoptosis response-4 protein (Par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate cancer cells by binding specifically to a receptor, Glucose-regulated protein-78 (GRP78), found only on the surface of cancer cells. 3-Arylquinolines or "arylquins" induce normal cells to release Par-4 from the intermediate filament protein, vimentin and promote Par-4 secretion that targets cancer cells in a paracrine manner. A structure-activity study identified arylquins that promote Par-4 secretion, and an evaluation of arylquin binding to the hERG potassium ion channel using a [(3)H]-dofetilide binding assay permitted the identification of structural features that separated this undesired activity from the desired Par-4 secretory activity. A binding study that relied on the natural fluorescence of arylquins and that used the purified rod domain of vimentin (residues 99-411) suggested that the mechanism behind Par-4 release involved arylquin binding to multiple sites in the rod domain.

  17. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  18. Pars Planitis: Epidemiology, Clinical Characteristics, Management and Visual Prognosis.

    Science.gov (United States)

    Ozdal, Pinar Cakar; Berker, Nilufer; Tugal-Tutkun, Ilknur

    2015-01-01

    Pars planitis is an idiopathic chronic intermediate uveitis which predominantly affects children and adolescents, and accounts for 5-26.7% of pediatric uveitis. Although an autoimmune process with a genetic predisposition has been suggested, its etiology still remains unknown. The most common presenting symptoms are floaters and blurred vision. Diffuse vitreous cells, haze, snowballs and snowbanks are typical findings of pars planitis. Peripheral retinal vasculitis, optic disc edema and anterior segment inflammation are other well-known findings. Although pars planitis is known to be a benign form of uveitis in most cases, it may become a potentially blinding disease due to complications including cataract, cystoid macular edema, vitreous opacities and optic disc edema. Cystoid macular edema is the most common cause of visual morbidity. Band keratopathy, epiretinal membrane formation, vitreous condensation, neovascularizations, vitreous hemorrhage, retinal detachment, cyclitic membranes, glaucoma and amblyopia may develop as a consequence of the chronic course of the disease. Exclusion of infectious and non-infectious causes which may present with intermediate uveitis is of utmost importance before starting treatment. Treatment of pars planitis has been a controversial issue. There is no consensus specifically for treatment of cases with minimal inflammation and relatively good visual acuity. However, current experience shows that pars planitis may cause severe inflammation and needs an aggressive treatment. A stepladder approach including corticosteroids, immunosupressive agents, anti-tumor necrosis factor-alpha and pars plana vitrectomy and/or laser photocoagulation is the most commonly used method for treatment of pars planitis. Adequate control of inflammation and prompt detection of associated complications are crucial in order to improve the overall prognosis of the disease. PMID:27051493

  19. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  20. Par-4 Down-regulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy

    OpenAIRE

    Alvarez, James V.; Pan, Tien-chi; Ruth, Jason; Feng, Yi; Zhou, Alice; Pant, Dhruv; Grimley, Joshua S.; Wandless, Thomas J.; DeMichele, Angela; Chodosh, Lewis A.

    2013-01-01

    Most deaths from breast cancer result from tumor recurrence, but the mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is down-regulated during tumor recurrence and that Par-4 down-regulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor respon...

  1. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    , in smokers, predictive of long-term lung cancer development. Whether smoking cessation impacts the suPAR level is unknown. MATERIALS AND METHODS: Forty-eight smokers were randomized into three groups of 16: (i) continued to smoke 20 cigarettes per day, (ii) refrained from smoking and used transdermal...... nicotine patches and (iii) refrained from smoking and used placebo patches. Nonsmokers were included for comparison. suPAR and C-reactive protein (CRP) levels were measured by ELISA. RESULTS: At baseline, the suPAR level was significantly higher in the 48 smokers (median 3·2 ng mL, IQR (2·5-3·9)) than...... in 46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  2. Humorale, endotheliale und mechanische Faktoren der Vasoregulation – Detektion neuer Systeme und therapeutische Beeinflussbarkeit

    OpenAIRE

    Timm H Westhoff

    2010-01-01

    The regulation of vasomotor tone is mediated by a dynamic interplay of various local and systemic parameters. Imbalances in this complex system may play a role in the pathogenesis of hypertension. The first part of the present work describes the identification and pharmacological characterization of new humoral vasoactive substances and the search for new differentially expressed blood pressure regulating genes. The second part describes clinical trials on the measurement of arterial function...

  3. Utilisation de l'essai comete et du biomarqueur gamma-H2AX pour detecter les dommages induits a l'ADN cellulaire par le 5-bromodeoxyuridine post-irradiation

    Science.gov (United States)

    La Madeleine, Carole

    Ce memoire est presente a la Faculte de medecine et des sciences de la sante de l'Universite de Sherbrooke en vue de l'obtention du grade de maitre es sciences (M.Sc.) en radiobiologie (2009). Un jury a revise les informations contenues dans ce memoire. Il etait compose de professeurs de la Faculte de medecine et des sciences de la sante soit : Darel Hunting PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Leon Sanche PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Richard Wagner PhD, membre du programme (departement de medecine nucleaire et radiobiologie) et Guylain Boissonneault PhD, membre exterieur au programme (departement de biochimie). Le 5-bromodeoxyuridine (BrdU), un analogue halogene de la thymidine reconnu depuis les annees 60 comme etant un excellent radiosensibilisateur. L'hypothese la plus repandue au sujet de l'effet radio sensibilisant du BrdU est qu'il augmente le nombre de cassures simple et double brin lorsqu'il est incorpore dans l'ADN de la cellule et expose aux radiations ionisantes. Toutefois, de nouvelles recherches semblent remettre en question les observations precedentes. Ces dernieres etudes ont confirme que le BrdU est un bon radiosensibilisateur, car il augmente les dommages radio-induits dans l'ADN. Mais, c'est en etant incorpore dans une region simple brin que le BrdU radiosensibilise l'ADN. Ces recherches ont egalement revele pour la premiere fois un nouveau type de dommages produits lors de l'irradiation de l'ADN contenant du BrdU : les dimeres interbrins. Le but de ces travaux de recherche est de determiner si la presence de bromodeoxyuridine dans l'ADN augmente l'induction de bris simple et / ou double brin chez les cellules irradiees en utilisant de nouvelles techniques plus sensibles et specifiques que celles utilisees auparavant. Pour ce faire, les essais cometes et la detection des foci H2AX phosphorylee pourraient permettre d'etablir les effets engendres par

  4. OXYDATION DU CYCLOHEXANE PAR COMPLEXE DE RUTHÉNIUM

    OpenAIRE

    HAMOUDI, Badreddine

    2008-01-01

    Le complexe RuCl2(PPh3)3 a été préparé dans le but de son application sur la réaction d’oxydation du cyclohexane en cyclhexanol et cyclohexanone. Les analyses par chromatographie en phase gaz sur la phase organique montrent la production de l’alcool et la cétone dans le cas du t-BuOOH comme oxydant, ce qui n’est le cas avec l’eau oxygénée et l’oxygène moléculaire. La réaction a été effectuée dans différents solvants, où l’eau a apportée une meilleure conversion par rapport a...

  5. Terapia Miofuncional en pacientes con parálisis cerebral

    OpenAIRE

    Gónzalez Amigo, José

    2015-01-01

    En el presente trabajo, se va a llevar a cabo una visión de la parálisis cerebral desde el punto de vista de la motricidad. La parálisis cerebral es una patología que se caracteriza fundamentalmente por una alteración a nivel motriz, que puede afectar a las diferentes extremidades así como a los órganos involucrados en el habla. Estas limitaciones en la región orofacial pueden producir importantes distorsiones y como consecuencia el discurso puede resultar ininteligible para los interlocutore...

  6. La parálisis cerebral en el cine

    OpenAIRE

    Merino Marcos, María Lucila

    2005-01-01

    [ES] En los últimos veinticinco años se han rodado un número importante de películas en las que el protagonista o algún personaje secundario presentaban o simulaban una parálisis cerebral. Estos personajes en ocasiones han sido interpretados por personas con minusvalías. En la narración de su historia las cintas han incluido diversos aspectos sanitario-asistenciales, sociales y familiares obligados en el campo de la parálisis cerebral. [EN] In the last twenty-five years, a number of import...

  7. Apprentissage par Renforcement Développemental en Robotique Autonome

    OpenAIRE

    Sarzyniec, Luc; Buffet, Olivier; Dutech, Alain

    2011-01-01

    National audience Cet article présente une approche développementale de l'apprentissage par renforcement dans un cadre de robotique autonome. Le but est de permettre au robot de tirer parti de la richesse de son environnement sans que cette richesse ne le noie sous trop d'information à traiter. L'idée principale testée ici est de faire croître les capacités perceptives et motrices de l'agent au fur et à mesure de l'apprentissage. Cette approche est combinée avec un apprentissage par renfor...

  8. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  9. Predicting Spectral and PAR Light Attenuation in Greenlandic Coastal Waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Stedmon, Colin A.; Markager, Stiig

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  10. Problemes methodologiques poses par l'extraction et la recuperation des bacteries telluriques pour leur quantification par immunofluorescence

    OpenAIRE

    Crozat, Y.; Cleyet-Marel, Jean Claude

    1984-01-01

    Afin d’améliorer la valeur quantitative de la technique de dénombrement des bactéries telluriques (Rhizobium japonicum) par immunofluorescence, on compare différents modes d’extraction et de récupération. L’utilisation de membranes en polycarbonates (Nucléopores) supprime les 40 p. 100 de pertes occasionnées par les membranes cellulosiques (Millipores) classiquement employées. Parmi les différents floculants testés, Ca(OH)2/MgCO3(2/5) permet d’obtenir les meilleurs résultats. Cependant po...

  11. Limitation des populations de ravageurs de l’olivier par le recours à la lutte biologique par conservation

    OpenAIRE

    Warlop, Francois

    2006-01-01

    L’olivier est une culture relativement rustique, mais qui peut être fortement attaquée par la mouche Bactrocera oleae (Gmelin), son principal ravageur. Les parasitoïdes de cette mouche sont connus, mais leur impact sur les populations de Diptères demeure faible, faute d’aménagement adéquat du paysage et suite à une intensification abusive des pratiques culturales. Le programme d’installation de bandes florales mené par le Groupe de recherches en agriculture biologique qui a débuté en 2004 vis...

  12. Pollution par les nitrates: quels remèdes?

    OpenAIRE

    Zilliox, Lothaire; Schenck, Charles; Kobus, Helmut; Huwe, Bernd

    1990-01-01

    Au cours des dix dernières années, la pollution des eaux souterraines par les nitrates n'a cessé d'augmenter. Principale accussée: l'agriculture, l'application de méthodes de techniques culturales devrait permettre une meilleure gestion des engrais azotés.

  13. Radiative Transfer Code: Application to the calculation of PAR

    Indian Academy of Sciences (India)

    D Emmanuel; D Phillippe; C Malik

    2000-12-01

    The production of carbon in the ocean, the so-called primary production, depends on various physico- biological parameters: the biomass and nutrient amounts in oceans, the salinity and temperature of the water and the light available in the water column. We focus on the visible spectrum of the solar radiation defined as the Photosynthetically Active Radiation (PAR). We developed a model (Chami et al. 1997) to simulate the behavior of the solar beam in the atmosphere and the ocean. We first describe the theoretical basis of the code and the method we used to solve the radiative transfer equation (RTE): the successive orders of scattering (SO). The second part deals with a sensitivity study of the PAR just above and below the sea surface for various atmospheric conditions. In a cloudy sky, we computed a ratio between vector fluxes just above the sea surface and spherical fluxes just beneath the sea surface. When the optical thickness of the cloud increases this ratio remains constant and around 1.29. This parameter is convenient to convert vector flux at the sea surface as retrieved from satellite to PAR. Subsequently, we show how solar radiation as vector flux rather than PAR leads to an underestimate of the primary production up to 40% for extreme cases.

  14. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  15. PH motifs in PAR1&2 endow breast cancer growth.

    Science.gov (United States)

    Kancharla, A; Maoz, M; Jaber, M; Agranovich, D; Peretz, T; Grisaru-Granovsky, S; Uziely, B; Bar-Shavit, R

    2015-01-01

    Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Here we show signal-binding motifs in PAR1&2 that are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26600192

  16. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    OpenAIRE

    Anna Gustafsson; Vjosa Ajeti; Lennart Ljunggren

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to ...

  17. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob;

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA...

  18. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    Science.gov (United States)

    Gustafsson, Anna; Ajeti, Vjosa; Ljunggren, Lennart

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to plasma suPAR, CRP, BMI, or gender. Blood and unstimulated whole saliva was collected from 20 healthy individuals (10 female and 10 male, median age of 28 years; range 21–41). CRP and suPAR were measured with ELISA in saliva and serum/plasma. suPAR was detected in all saliva samples in the 5.2–28.1 ng/mL range, with a median value of 17.1 ng/mL. Saliva suPAR was significantly higher (P < 0.001) but not correlated to plasma suPAR in healthy young adults with normal plasma suPAR levels. suPAR and CRP levels were correlated in blood but not in saliva. No correlation was found between BMI, age, or gender and suPAR in saliva. PMID:22084570

  19. ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

    Science.gov (United States)

    The small serine resolvase ParA from bacterial plasmids RK2 and RP4 catalyzes the recombination of two identical 133 bp recombination sites known as MRS. Previously, we reported that ParA is active in the fission yeast Schizosaccharomyces pombe. In this work, the parA recombinase gene was placed un...

  20. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi

    NARCIS (Netherlands)

    J.W.R. Hovius; M.F. Bijlsma; G.J.W. van der Windt; W.J. Wiersinga; B.J.D. Boukens; J. Coumou; A. Oei; R. de Beer; A.F. de Vos; C. van 't Veer; A.P. van Dam; P. Wang; E. Fikrig; M.M. Levi; J.J.T.H. Roelofs; T. van der Poll

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also

  1. Is There an "F" in Your PAR? Understanding, Teaching and Doing Action Research

    Science.gov (United States)

    Lorenzetti, Liza; Walsh, Christine Ann

    2014-01-01

    Participatory Action Research (PAR) is increasingly recognized within academic research and pedagogy. What are the benefits of including feminism within participatory action research and teaching? In responding to this question, we discuss the similarities and salient differences between PAR and feminist informed PAR (FPAR). There are eight themes…

  2. ParCAT: A Parallel Climate Analysis Toolkit

    Science.gov (United States)

    Haugen, B.; Smith, B.; Steed, C.; Ricciuto, D. M.; Thornton, P. E.; Shipman, G.

    2012-12-01

    Climate science has employed increasingly complex models and simulations to analyze the past and predict the future of our climate. The size and dimensionality of climate simulation data has been growing with the complexity of the models. This growth in data is creating a widening gap between the data being produced and the tools necessary to analyze large, high dimensional data sets. With single run data sets increasing into 10's, 100's and even 1000's of gigabytes, parallel computing tools are becoming a necessity in order to analyze and compare climate simulation data. The Parallel Climate Analysis Toolkit (ParCAT) provides basic tools that efficiently use parallel computing techniques to narrow the gap between data set size and analysis tools. ParCAT was created as a collaborative effort between climate scientists and computer scientists in order to provide efficient parallel implementations of the computing tools that are of use to climate scientists. Some of the basic functionalities included in the toolkit are the ability to compute spatio-temporal means and variances, differences between two runs and histograms of the values in a data set. ParCAT is designed to facilitate the "heavy lifting" that is required for large, multidimensional data sets. The toolkit does not focus on performing the final visualizations and presentation of results but rather, reducing large data sets to smaller, more manageable summaries. The output from ParCAT is provided in commonly used file formats (NetCDF, CSV, ASCII) to allow for simple integration with other tools. The toolkit is currently implemented as a command line utility, but will likely also provide a C library for developers interested in tighter software integration. Elements of the toolkit are already being incorporated into projects such as UV-CDAT and CMDX. There is also an effort underway to implement portions of the CCSM Land Model Diagnostics package using ParCAT in conjunction with Python and gnuplot. Par

  3. Valorisation de biogaz pour industrie chimie par voie catalytique

    OpenAIRE

    Taimoor, Aqeel Ahmad

    2010-01-01

    La production de l'hydrogène à partir de biomasse est actuellement à l'étude mais la méthode de valorisation du biogaz (mélange H2/CO2) par réactions catalytiques, autres que la simple combustion, n'a pas encore été retenue. Par conséquent, le principal objectif de ce travail est d'explorer les autres voies. L'effet du CO2 sur le système catalytique est mal connu et seulement un effet négatif sur la dissociation de l'hydrogène a été mentionné. L'hydrogénation du toluène sur un catalyseur Pt a...

  4. Des guides touristiques pour le peuple et par le peuple

    Directory of Open Access Journals (Sweden)

    Ninon Vinsonneau

    2006-04-01

    Full Text Available Le Federal Writers’ Project (FWP constitua l’un des quatre programmes « culturels » lancés par l’administration du New Deal en 1935 en vue de résorber le problème du chômage parmi les professions dites « en col blanc ». Il employa de 1935 à 1943, entre quatre et six mille chômeurs par an, tous membres des « professions de l’écrit » — les « écrivains », au sens large que l’administration fédérale donnait à ce terme : romanciers, poètes, dramaturges, mais aussi journalistes, enseignants, cherc...

  5. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  6. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    OpenAIRE

    Mutoh T; Kadoya K; Chikuda M

    2012-01-01

    Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females) after 25-gauge pars plana vitrectomy (PPV). One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedu...

  7. «La Promenade par les aventures surprenants»

    OpenAIRE

    Duarte, Alexandre Freire

    2010-01-01

    É nossa intenção, neste estudo, focar a atenção heurística no par: Jean-Joseph Surin (1600-1665), e Michel de Certeau, um homem que, intermitentemente – revelando uma vida queimada pelo fascínio por Jean-Joseph Surin –, constituiu, nas nossas mãos atentamente vazias, num vasto arvoredo que nos remetia continuamente para uma sombria clareira luminosa que irradiava do meio daquele.

  8. The ParMol package for frequent subgraph mining

    OpenAIRE

    Meinl, Thorsten; Wörlein, Marc; Urzova, Olga; Fischer, Ingrid; Philippsen, Michael

    2006-01-01

    Mining for frequent subgraphs in a graph database has become a popular topic in the last years. Algorithms to solve this problem are used in chemoinformatics to find common molecular fragments in a database of molecules represented as two-dimensional graphs. However; the search process in arbitrary graph structures includes costly graph and subgraph isomorphism tests. In our ParMol package we have implemented four of the most popular frequent subgraph miners using a common infrastructure: MoF...

  9. Taare Zameen Par and dyslexic savants

    OpenAIRE

    Chakravarty Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were ...

  10. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH2, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  11. Diagnostic Ultrasound and Pars Plana Vitrectomy in Endophthalmitis

    Institute of Scientific and Technical Information of China (English)

    Jingjing Huang; Zhenfang Wang; Lijuan Zou; Xiaofeng Lin; Yiwen Luo; Zhaohui Yuan

    2004-01-01

    Purpose: To compare the results by B-scan ultrasonography and findings in pars plana vitrectomy, and assess the diagnostic value of B-scan ultrasonography in endophthalmitis.Methods: Thirty eyes of 30 subjects diagnosed as endophthalmitis were selected, who undergone preoperative B-scan ultrasonography. The result of pars plana vitrectomy was recorded. The above two results were compared.Results: On the evaluation of vitreous and retinal states in the patients with endophthalmitis, the sensitivity of ultrasound was 90%~100%, and the specificity was 79%~100%.Poorer preoperative visual acuity was related with retinal detachment and retinal dissolution. The preoperative visual acuity in eyes with local vitreous opacity was better than with diffuse vitreous opacity.Conclusion: Comparison of the results of B-scan ultrasonography and the findings in pars plana vitrectomy showed B-scan ultrasonography is highly sensitive, specific, and is very helpful in the evaluation of endophthalmitis. B-scan ultrasonography can not only supply much information in the diagnosis of endophthalmitis but also inspect its trends and changes, which is helpful in the selection of treatment and planning the time of surgery.

  12. ParB Partition Proteins: Complex Formation and Spreading at Bacterial and Plasmid Centromeres.

    Science.gov (United States)

    Funnell, Barbara E

    2016-01-01

    In bacteria, active partition systems contribute to the faithful segregation of both chromosomes and low-copy-number plasmids. Each system depends on a site-specific DNA binding protein to recognize and assemble a partition complex at a centromere-like site, commonly called parS. Many plasmid, and all chromosomal centromere-binding proteins are dimeric helix-turn-helix DNA binding proteins, which are commonly named ParB. Although the overall sequence conservation among ParBs is not high, the proteins share similar domain and functional organization, and they assemble into similar higher-order complexes. In vivo, ParBs "spread," that is, DNA binding extends away from the parS site into the surrounding non-specific DNA, a feature that reflects higher-order complex assembly. ParBs bridge and pair DNA at parS and non-specific DNA sites. ParB dimers interact with each other via flexible conformations of an N-terminal region. This review will focus on the properties of the HTH centromere-binding protein, in light of recent experimental evidence and models that are adding to our understanding of how these proteins assemble into large and dynamic partition complexes at and around their specific DNA sites. PMID:27622187

  13. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob;

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...... the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  14. The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation.

    Science.gov (United States)

    Khan, Aasma; Li, Dongjun; Ibrahim, Salam; Smyth, Emer; Woulfe, Donna S

    2014-07-01

    It is now well accepted that protease activated receptor (PAR) 1 and PAR4 have differential roles in platelet activation. PAR4, a low-affinity thrombin receptor in human platelets, participates in sustained platelet activation in a P2Y12-dependent manner; however, the mechanisms are not defined. Our previous studies demonstrated that thrombin induces the association of PAR4 with P2Y12, together with arrestin recruitment to the complex. Here we show that PAR4 and P2Y12 directly interact to coregulate Akt signaling after PAR4 activation. We observed direct and specific interaction of P2Y12 with PAR4 but not PAR1 by bioluminescent resonance energy transfer when the receptors were coexpressed in human embryonic kidney 293T cells. PAR4-P2Y12 dimerization was promoted by PAR4-AP and inhibited by P2Y12 antagonist. By using sequence comparison of the transmembrane domains of PAR1 and PAR4, we designed a mutant form of PAR4, "PAR4SFT," by replacing LGL194-196 at the base of transmembrane domain 4 with the corresponding aligned PAR1 residues SFT 220-222. PAR4SFT supported only 8.74% of PAR4-P2Y12 interaction, abolishing P2Y12-dependent arrestin recruitment to PAR4 and Akt activation. Nonetheless, PAR4SFT still supported homodimerization with PAR4. PAR4SFT failed to induce a calcium flux when expressed independently; however, coexpression of increasing concentrations of PAR4SFT, together with PAR4 potentiated PAR4-mediated calcium flux, suggested that PAR4 act as homodimers to signal to Gq-coupled calcium responses. In conclusion, PAR4 LGL (194-196) governs agonist-dependent association of PAR4 with P2Y12 and contributes to Gq-coupled calcium responses. PAR4-P2Y12 association supports arrestin-mediated sustained signaling to Akt. Hence, PAR4-P2Y12 dimerization is likely to be important for the PAR4-P2Y12 dependent stabilization of platelet thrombi. PMID:24723492

  15. Contribution to the radiological study of the eosinophilic granuloma of the mandible (Unifocal granuloma due to Langherans' cell histiocytosis); Contributo allo studio radiologico del granuloma eosinofilo della mandibola (granuloma unifocale da istiocitosi delle cellule di Lagherhans)

    Energy Technology Data Exchange (ETDEWEB)

    Chigi, Gino; Pastremoli, Alessandro; Pisi, Paolo; Pastremoli, Alfredo [Bologna Univ., Bologna (Italy). Dipartimento di scienze odontomastologiche; Bianchi, Giuseppe [Istituti Ortopedici Rizzoli, Bologna (Italy)

    2005-04-01

    non completamente risolto per talune condizioni patologiche, nelle quali i dati obiettivi ed anamnestici sono relativamente uniformi e il quadro radiologico privo di qualsiasi caratteristica. Materiale e metodi: Il materiale � costituito da sei casi di istiocitosi delle cellule di Langherans della mandibola osservati nell'arco di un decennio. Lo studio � basato sulla valutazione della documentazione radiologica tradizionale. Le radiografie sono state eseguite in proiezione latero-laterale-obliqua che, come noto, libera quasi completamente la porzione orizzontale della mandibola dalla sovrapposizione delle immagini di altre strutture ossee. Risultati: I risultati delle indagini radiologiche sono riportati nella tabella I. Si tratta di reticoloendoteliopatie capaci di dar luogo ad un processo granulomatoso costituito da polinucleati eosinofili, plasmacellule e linfociti e, fondamentalmente, da grandi cellule istiocitarie mononucleate dotate di attivit� granulopessica e fagocitaria, spiccatamente proliferanti nel tessuto osseo, identificabili con le cellule di Langherhans della pelle, delle mucose, degli spazi periodontali, del midollo osseo. Il tessuto granulomatoso che ne deriva si infiltra tra gli elementi costitutivi dell'organo colpito ed estendendosi comprime, atrofizza e tende a distruggere il tessuto, sostituendosi ad esso. Le alterazioni determinate dal granuloma isiocitario di Langherhans prevalgono nettamente nel sistema scheletrico e si verificano, in ordine di frequenza, nel cranio, nelle ossa lunghe dell'estremit�, nel piede, nelle coste e nella colonna vertebrale. L'interessamento della mucosa orale � eccezionale. Conclusioni: Nel granuloma istiocitario unifocale di Langherhans della mandibola l'indagine radiologica � indispensabile per l'approccio allo studio della tumefazione premandibolare fermo restando che la diagnosi di natura si basa esclusivamente sulla biopsia. Oltre all'esame radiologico digitale o

  16. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  17. A model for the condensation of the bacterial chromosome by the partitioning protein ParB

    Science.gov (United States)

    Broedersz, Chase; Wingreen, Ned

    2013-03-01

    The molecular machinery responsible for faithful segregation of the chromosome in bacteria such as Caulobacter crescentus and Bacillus subtilis includes the ParABS a.k.a. Spo0J/Soj partitioning system. In Caulobacter, prior to division, hundreds of ParB proteins bind to the DNA near the origin of replication, and localize to one pole of the cell. Subsequently, the ParB-DNA complex is translocated to the far pole by the binding and retraction of the ParA spindle-like apparatus. Remarkably, the localization of ParB proteins to specific regions of the chromosome appears to be controlled by only a few centromeric parS binding sites. Although lateral interactions between DNA-bound ParB are likely to be important for their localization, the long-range order of ParB domains on the chromosome appears to be inconsistent with a picture in which protein-protein interactions are limited to neighboring DNA-bound proteins. We developed a coarse-grained Brownian dynamics model that allows for lateral and 3D protein-protein interactions among bound ParB proteins. Our model shows how such interactions can condense and organize the DNA spatially, and can control the localization and the long-range order of the DNA-bound proteins.

  18. Évolution des conditions d’initiation du traitement antirétroviral des patients infectés par le VIH en Afrique de l’Ouest

    Science.gov (United States)

    Bashi, J.; Balestre, E.; Messou, E.; Maiga, M.; Coffie, P.A.; Zannou, D.M.; Ba-Gomis, O.; Traore, H.A.; Eholie, S.; Minga, A.; Sow, P.S.; Bissagnene, E.; Dabis, F.; Ekouevi, D.K.

    2013-01-01

    Résumé Objectif Étudier entre 1996 et 2006, l’évolution des schémas thérapeutiques et du profil clinique et immunologique des patients infectés par le VIH au début du traitement antirétroviral (TARV) en Afrique de l’Ouest. Cadre et méthode Les données issues de 12 centres cliniques adultes (IeDEA West Africa réseau collaboratif de prise en charge de l’infection à VIH) de cinq pays (Bénin, Cote d’Ivoire, Sénégal, Gambie, Mali) ont été mises en commun et analysées. Les patients âgés de 16 ans et plus dont le sexe, la date de naissance et la date d’initiation du TARV étaient connus ont été inclus dans cette étude. Résultats Quatorze mille quatre-cent-quatre-vingt-seize patients avaient débuté un TARV entre 1996–2006 avec 55 % des patients l’ayant débuté entre 2005–2006. La proportion de femmes était de 46 % en 1996–2000 et de 63 % en 2005–2006. L’âge médian à la mise sous traitement était constant: 35 ans chez les femmes et 40 ans chez les hommes. La proportion de patients qui ont débuté le TARV avec un taux de CD4 inférieur à 200 cellules/µl était de 54 % en 1996–2000 et de 64 % en 2005–2006. Les combinaisons thérapeutiques les plus prescrites étaient: AZT/3TC (ou d4T/DDI)/IDV (27 %) en 1996–2000; d4T (ou AZT)/3TC/EFV (59 %) en 2003–2004; et d4T/3TC/NVP (49 %) en 2005–2006. Les traitements de première ligne recommandés par l’OMS étaient débutés dans 83 % de cas en 2005–2006. Conclusion De nouvelles approches pour débuter un TARV plus précocement doivent être développées pour améliorer la survie des patients sous TARV. PMID:20045273

  19. Décontamination nucléaire par laser UV

    Science.gov (United States)

    Delaporte, Ph.; Gastaud, M.; Marine, W.; Sentis, M.; Uteza, O.; Thouvenot, P.; Alcaraz, J. L.; Le Samedy, J. M.; Blin, D.

    2003-06-01

    Le développement et l'utilisation de procédés propres pour le nettoyage ou la préparation de surfaces est l'une des priorités du milieu industriel. Cet intérêt est d'autant plus grand dans le domaine du nucléaire pour lequel la réduction des déchets est un axe de recherche important. Un dispositif de décontamination nucléaire par laser UV impulsionnel a été développé et testé. Il est composé. d'un laser à excimères de 1kW, d'un faisceau de fibres optiques et d'un dispositif de récupération des particules. Les essais réalisés en milieu actif ont démontré sa capacité à nettoyer des surfaces métalliques polluées par différents radioéléments avec des facteurs de décontamination généralement supérieurs à 10. Ce dispositif permet de décontaminer de grandes surfaces de géométrie simple en réduisant fortement la génération de déchets secondaires. Il est, à ce jour et dans ces conditions d'utilisations, le procédé de décontamination par voie sèche le plus efficace.

  20. Monitoreo de parásitos en efluentes domiciliarios

    OpenAIRE

    Liliana Semenas; Norma Brugni; Gustavo Viozzi; Ana Kreiter

    1999-01-01

    OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente ...

  1. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  2. INCORPORATION DU PHOSPHORE DANS CdTe PAR RECUIT LASER

    OpenAIRE

    Uzan, C.; Legros, R.; Marfaing, Y.

    1983-01-01

    La méthode du recuit laser a été utilisée pour incorporer du phosphore dans CdTe à partir d'une couche de Cd3P2 déposée en surface. La caractérisation par photoluminescence et mesure de profil à l'analyseur ionique montre le caractère actif du phosphore introduit et permet d'évaluer à 1018cm-3 la concentration atteinte à 1 µm de profondeur.

  3. Alex: incluir la parálisis cerebral

    OpenAIRE

    Ayuela Fernández, Mª del Mar

    2013-01-01

    El presente trabajo se basa en un estudio de caso: Alex. Un niño con una parálisis cerebral tipo espástico y su inclusión, bajo el proceso de enseñanza-aprendizaje durante el curso 2012-2013 en dos escenarios: familia y colegio. En un primer momento señalaremos los objetivos planteados a raíz de los interrogantes que nos suscita el trabajar con niños y niñas con necesidades educativas especiales. Posteriormente y tras un encuadre teórico y metodológico, abordaremos una propuesta de intervenci...

  4. Videojuego adaptado para personas con parálisis cerebral

    OpenAIRE

    Gómez Davó, Roberto

    2014-01-01

    La parálisis cerebral describe un grupo de trastornos del desarrollo psicomotor, que causan una limitación de la actividad de la persona, es decir, es un padecimiento que principalmente se caracteriza por la inhabilidad de poder controlar completamente las funciones del sistema motor. Esto puede incluir espasmos o rigidez en los músculos, movimientos involuntarios, y/o trastornos en la postura o movilidad del cuerpo. Estos trastornos psicomotores imposibilitan su interacción con los sistemas ...

  5. INNOVATIONS ET GOUVERNANCE TERRITORIALE : UNE ANALYSE PAR LES DISPOSITIFS

    OpenAIRE

    Soulard, Christophe-Toussaint; Mathé, Syndhia; Michel, Laura; Nougaredes, Brigitte; Jarrige, Françoise; Maurel, Pierre; Clement, Camille; Martinand, Pierre; Guiheneuf, Pierre-Yves; Barbe, Eric

    2010-01-01

    Cette communication vise à présenter les outils méthodologiques d’analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s’agit d’étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dans un contexte de recomposi...

  6. Innovation et gouvernance territoriale : une analyse par les dispositifs

    OpenAIRE

    Rey Valette, H.; Chia, E; Soulard, C.; Mathé, S.; Michel, L.; Nougaredes, B.; Jarrige, F.; Maurel, P.; Clement, C.; Martinand, P.; Guiheneuf, P.Y.; Barbe, E.

    2010-01-01

    International audience Cette communication vise à présenter les outils méthodologiques d'analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s'agit d'étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dan...

  7. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  8. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  9. Localization of the ParC protein in Escherichia coli cells

    OpenAIRE

    2007-01-01

    The Escherichia coli ParC protein is one of two subunits of the topoisomerase IV, a type II topoisomerase. Topo IV is responsible for relaxing positive supercoils and decatenating linked daughter chromosomes after replication. This is done by introducing transient double-stranded breaks into the DNA, passing through a segment of uncut duplex DNA, before resealing the break. Mutations in parC lead to the par phenotype which is characterized by chromosomes that can replicate but are deficient i...

  10. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Directory of Open Access Journals (Sweden)

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  11. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  12. Condensation and localization of the partitioning protein ParB on the bacterial chromosome

    OpenAIRE

    Broedersz, Chase P.; Wang, Xindan; Meir, Yigal; Loparo, Joseph J.; Rudner, David Z.; Wingreen, Ned S.

    2014-01-01

    The ParABS system is responsible for chromosome and plasmid segregation in many bacteria. A large, coherent ParB–DNA complex forms the partitioning module at the heart of this segregation machinery. Here we provide a simple theoretical model for interacting proteins on DNA to elucidate the structure of the ParB–DNA complex. We show that that both 3D bridging and 1D spreading interactions between DNA-bound ParB proteins are required to ensure the formation of a coherent protein–DNA complex. Th...

  13. Structural and genetic analyses of a par locus that regulates plasmid partition in Bacillus subtilis.

    OpenAIRE

    Chang, S.; Chang, S Y; Gray, O

    1987-01-01

    The Bacillus plasmid pLS11 partitions faithfully during cell division. Using a partition-deficient plasmid vector, we randomly cloned DNA fragments of plasmid pLS11 and identified the locus that regulates plasmid partition (par) by cis complementation in Bacillus subtilis. The cloned par gene conferred upon the vector plasmid a high degree of segregational stability. The par locus was mapped to a 167-base-pair segment on pLS11, and its nucleotide sequence was determined. The cloned par fragme...

  14. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    DEFF Research Database (Denmark)

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric binding...... equation revealed, that in all preparations IGF-II was bound to one high-affinity binding site and other sites with lower affinities. The specificity of the high-affinity 125I-IGF-II binding to the membrane vesicles assessed by displacement by unlabeled IGF-II, IGF-I and insulin showed that IGF-I displaced...... 125I-IGF-II in the range 22.5-47.9 nM (IC50) whereas insulin did not effect 125I-IGF-II binding at all. beta-Galactosidase inhibited the 125I-IGF-II binding with half-maximal inhibition of 20-30 nM beta-galactosidase. D-Mannose 6-phosphate increased the binding of 125I-IGF-II and reversed...

  15. Le diagnostic anténatal de la trisomie 21 par l'hybridation in situ en fluorescence (FISH): à propos des premiers tests réalisés au Maroc

    Science.gov (United States)

    Lamzouri, Afaf; Natiq, Abdelhafid; Tajir, Mariam; Sendid, Mohamed; Sefiani, Abdelaziz

    2012-01-01

    Introduction Le but de cette étude était de présenter les premiers résultats de diagnostic anténatal de la trisomie 21 par la technique d'hybridation in situ en fluorescence (FISH) au Maroc et discuter son intérêt dans le diagnostic rapide de cette aneuploïdie. Méthodes Ce travail a été réalisé chez 23 femmes avec des grossesses à haut risque de trisomie 21. La moyenne d’âge des gestantes étaient de 37,43 ans avec des extrêmes de 21 et 43 ans. Toutes étaient musulmanes mariées, mariage légitimé par la Charia, dont trois mariages consanguins, sauf une originaire de la République Démocratique du Congo qui était chrétienne et concubine. La majorité des femmes étaient fonctionnaires et avaient un niveau de scolarisation moyen à élevé. Toutes les patientes ont bénéficié d'une consultation de génétique médicale au cours de laquelle il leur a été donné des informations sur la technique, son intérêt et ses limites. Il s'agit de femmes enceintes qui avaient soit un âge maternel élevé ou des signes d'appel échographiques et/ ou biochimiques. Une des patientes était porteuse d'une translocation robertsonienne t(14;21) équilibrée. Une amniocentèse a été réalisée chez toutes les gestantes et aucun avortement n'a était induit par ce geste invasif. L’âge gestationnel moyen à la première consultation était de 14 semaines d'aménorrhée (SA) et à l'amniocentèse était de 16 SA et 5 jours. L'analyse FISH a été réalisée, après consentement des couples, sur des cellules non cultivées à partir des échantillons de liquides amniotiques, en utilisant des sondes spécifiques du chromosome 21. Résultats Parmi les 23 patientes qui ont bénéficiées d'un diagnostic anténatal de la trisomie 21 par la technique FISH, nous avons pu rassurer 21 d'entre elles, et nous avons détecté deux cas de trisomie 21 fœtal. Conclusion La technique FISH permet un diagnostic anténatal rapide, en moins de 48h, de la trisomie 21 sur

  16. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

    Science.gov (United States)

    Edelstein, Leonard C.; Simon, Lukas M.; Lindsay, Cory R.; Kong, Xianguo; Teruel-Montoya, Raúl; Tourdot, Benjamin E.; Chen, Edward S.; Ma, Lin; Coughlin, Shaun; Nieman, Marvin; Holinstat, Michael; Shaw, Chad A.

    2014-01-01

    Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14% more PAR4 protein than those from whites (n = 84), but this difference is not associated with platelet PAR4 function. Quantitative trait locus analysis identified 3 common single nucleotide polymorphisms in the PAR4 gene (F2RL3) associated with PAR4-induced platelet aggregation. Among these single nucleotide polymorphisms, rs773902 determines whether residue 120 in transmembrane domain 2 is an alanine (Ala) or threonine (Thr). Compared with the Ala120 variant, Thr120 was more common in black subjects than in white subjects (63% vs 19%), was associated with higher PAR4-induced human platelet aggregation and Ca2+ flux, and generated greater inositol 1,4,5-triphosphate in transfected cells. A second, less frequent F2RL3 variant, Phe296Val, was only observed in blacks and abolished the enhanced PAR4-induced platelet aggregation and 1,4,5-triphosphate generation associated with PAR4-Thr120. PAR4 genotype did not affect vorapaxar inhibition of platelet PAR1 function, but a strong pharmacogenetic effect was observed with the PAR4-specific antagonist YD-3 [1-benzyl-3(ethoxycarbonylphenyl)-indazole]. These findings may have an important pharmacogenetic effect on the development of new PAR antagonists. PMID:25293779

  17. Pierre Vilar Frontinhan 1906 - París 2003

    Directory of Open Access Journals (Sweden)

    Pablo Rodríguez

    2010-08-01

    Full Text Available En el pasado mes de agosto falleció en París el historiador y maestro de tantas generaciones Pierre Vilar. Aunque había mantenido una intensa actividad de reflexión sobre los sucesos contemporáneos, ésta se vio afectada en 1991 luego que una grave enfermedad le negó la visión. Fue entonces cuando decidió con la ayuda de Rosa Congost escribir sus reflexiones y recuerdos, especie de memoria de juventud. Pensar Históricamente (Barcelona: Editorial Crítica, 1997, el libro que reúne estos ejercicios, es una obra de sumo interés para conocer la infancia, adolescencia y juventud de este connotado historiador.

  18. Usinage des Composites par Jet d'eau Abrasif

    OpenAIRE

    Cénac, François; Collombet, Francis; Zitoune, Rédouane; Déléris, Michel

    2011-01-01

    International audience; Le protocole expérimental de fraisage par jet d'eau abrasif obtenu sur aluminium est adapté aux matériaux composites. On met en exergue deux différences majeures liées à l'effet du JEA entre les composites et l'aluminium que sont l'usinabilité et les variabilités. L'usinabilité des matériaux composites étant plus grande que celle de l'aluminium pour le JEA, on propose des plages de paramètres différentes pour les composites, du fait des limitations des machines standar...

  19. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  20. Hemangioma capilar de la parótida. Abordaje transoral

    Directory of Open Access Journals (Sweden)

    Luis Domingo Sarra

    2014-10-01

    Presentamos un caso en una paciente adulta que consultó por una masa en la región parotídea y parálisis facial periférica con el mayor componente tumoral que se manifestaba en la cavidad oral. La ecografía mostró una masa sólida. La punción aspiración con aguja fina fue negativa con material hemático en 2 oportunidades. No tuvimos sospecha de la presencia de un tumor de origen vascular, por lo que no fue solicitada una RMN. El caso fue resuelto a través de un abordaje quirúrgico poco utilizado, tras obtener una biopsia por congelación negativa.

  1. Simulation numérique du soudage par frottement malaxage

    OpenAIRE

    Guerdoux, Simon

    2007-01-01

    Ce travail présente le développement d'un outil numérique. Une formulation arbitrairement lagrangienne-eulérienne (ALE) est implémentée dans le logiciel 3D éléments finis FORGE3® pour simuler les différentes étapes du procédé de soudage par frottement malaxage (FSW). Une méthode découplée est utilisée : a) les champs de vitesses, pressions et températures du matériau sont calculés, b) la vitesse de maillage est calculée à partir de l'évolution des frontières du domaine et d'un critère de raff...

  2. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  3. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  4. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. PMID:26310455

  5. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W;

    2011-01-01

    are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after......The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections......PAR levels as compared to patients with no deep infection focus. suPAR was found to be prognostic for mortality in receiver operator characteristic (ROC) curve analysis, which was not observed for serum C-reactive protein (CRP); the area under the curve (AUC) for suPAR was 0.754 (95% confidence interval [CI...

  6. 12 CFR 925.19 - Par value and price of stock.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Par value and price of stock. 925.19 Section 925.19 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES MEMBERS OF THE BANKS Stock Requirements § 925.19 Par value and price of stock. The capital...

  7. Effect of pre-drying and par-frying conditions on the crispness of French fries

    NARCIS (Netherlands)

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all sampl

  8. Structure and ligand interactions of the urokinase receptor (uPAR)

    DEFF Research Database (Denmark)

    Kjærgaard, Magnus; Hansen, Line; Jacobsen, Benedikte;

    2008-01-01

    on disulfide connectivities, and they adopt a characteristic three-finger fold. Interestingly, the gene for uPAR is localized in a cluster of 6 homologous genes encoding proteins with multiple LU-domains. The structural biology of uPAR will be reviewed with special emphasis on its multidomain composition...

  9. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  10. Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    DEFF Research Database (Denmark)

    Hansen, Line; Larsen, Esben Kjær Unmack; Nielsen, Erik Holm;

    2013-01-01

    patient prognosis shared by several cancers including breast, colorectal, and gastric cancers. Conjugation of a uPAR specific targeting peptide onto polyethylene glycol (PEG) coated USPIO nanoparticles by click chemistry resulted in a five times higher uptake in vitro in a uPAR positive cell line compared...

  11. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability.

    Science.gov (United States)

    Kimura, Tetsuya; Sakai, Toshinori; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-06-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare. PMID:27340539

  12. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  13. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  14. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  15. CERCLA interim action at the Par Pond unit: A case study

    International Nuclear Information System (INIS)

    The Par Pond unit designated under CERCLA consists of sediments within a Savannah River Site (SRS) cooling water reservoir. The sediments are contaminated with radionuclides and nonradioactive constituents from nuclear production reactor operations. The mercury in Par Pond is believed to have originated from the Savannah River. Because of Par Pond Dam safety Issues, the water level of the reservoir was drawn down, exposing more than 1300 acres of contaminated sediments and triggering the need for CERCLA interim remedial action. This paper presents the interim action approach taken with Par Pond as a case study. The approach considered the complexity of the Par Pond ecosystem, the large size of Par Pond, the volume of contaminated sediments, and the institutional controls existing at SRS. The Environmental Protection Agency (EPA) considers units with large volumes of low-concentration wastes, as is the case with Par Pond, to be open-quotes special sites.close quotes Accordingly, EPA guidance establishes that the range of alternatives developed focus primarily on containment options and other remedial approaches that mitigate potential risks associated with the open-quotes special site.close quotes The remedial alternatives, according to EPA, are not to be prohibitively expensive or difficult to implement. This case study also is representative of the types of issues that will need to be addressed within the Department of Energy (DOE) complex as nuclear facilities are transitioned to inactive status and corrective/remedial actions are warranted

  16. Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity

    Directory of Open Access Journals (Sweden)

    Wu QiNan

    2016-01-01

    Full Text Available Apoptosis of islet β cells is a primary pathogenic feature of type 2 diabetes, and ER stress and mitochondrial dysfunction play important roles in this process. Previous research has shown that prostate apoptosis response-4 (Par-4/NF-κB induces cancer cell apoptosis through endoplasmic reticulum (ER stress and mitochondrial dysfunction. However, the mechanism by which Par-4/NF-κB induces islet β cell apoptosis remains unknown. We used a high glucose/palmitate intervention to mimic type 2 diabetes in vitro. We demonstrated that the high glucose/palmitate intervention induced the expression and secretion of Par-4. It also causes increased expression and activation of NF-κB, which induced NIT-1 cell apoptosis and dysfunction. Overexpression of Par-4 potentiates these effects, whereas downregulation of Par-4 attenuates them. Inhibition of NF-κB inhibited the Par-4-induced apoptosis. Furthermore, these effects occurred through the ER stress cell membrane and mitochondrial pathway of apoptosis. Our findings reveal a novel role for Par-4/NF-κB in islet β cell apoptosis and type 2 diabetes.

  17. Identification of uPAR-positive chemoresistant cells in small cell lung cancer.

    Directory of Open Access Journals (Sweden)

    Margarita Gutova

    Full Text Available BACKGROUND: The urokinase plasminogen activator (uPA and its receptor (uPAR/CD87 are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR system has been of great interest in cancer research because it is involved in the development of most invasive cancer phenotypes and is a strong predictor of poor patient survival. However, little is known about the role of uPA/uPAR in small cell lung cancer (SCLC, the most aggressive type of lung cancer. We therefore determined whether uPA and uPAR are involved in generation of drug resistant SCLC cell phenotype. METHODS AND FINDINGS: We screened six human SCLC cell lines for surface markers for putative stem and cancer cells. We used fluorescence-activated cell sorting (FACS, fluorescence microscopy and clonogenic assays to demonstrate uPAR expression in a subpopulation of cells derived from primary and metastatic SCLC cell lines. Cytotoxic assays were used to determine the sensitivity of uPAR-positive and uPAR-negative cells to chemotherapeutic agents. The uPAR-positive cells in all SCLC lines demonstrated multi-drug resistance, high clonogenic activity and co-expression of CD44 and MDR1, putative cancer stem cell markers. CONCLUSIONS: These data suggest that uPAR-positive cells may define a functionally important population of cancer cells in SCLC, which are resistant to traditional chemotherapies, and could serve as critical targets for more effective therapeutic interventions in SCLC.

  18. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  19. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

    2011-11-18

    The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  20. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation.

    Directory of Open Access Journals (Sweden)

    Hem C Jha

    2016-07-01

    Full Text Available Studies have suggested that Epithelial-Mesenchymal Transition (EMT and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA encoded by Kaposi's Sarcoma associated herpesvirus (KSHV regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies. In this study, we demonstrate that Par3 is significantly up-regulated in KSHV-infected primary B-cells. Further, Par3 interacted with LANA in KSHV positive and LANA expressing cells which led to translocation of Par3 from the cell periphery to a predominantly nuclear signal. Par3 knockdown led to reduced cell proliferation and increased apoptotic induction. Levels of SNAIL was elevated, and E-cadherin was reduced in the presence of LANA or Par3. Interestingly, KSHV infection in primary B-cells led to enhancement of SNAIL and down-regulation of E-cadherin in a temporal manner. Importantly, knockdown of SNAIL, a major EMT regulator, in KSHV cells resulted in reduced expression of LANA, Par3, and enhanced E-cadherin. Also, SNAIL bound to the promoter region of p21 and can regulate its activity. Further a SNAIL inhibitor diminished NF-kB signaling through upregulation of Caspase3 in KSHV positive cells in vitro. This was also supported by upregulation of SNAIL and Par3 in BC-3 transplanted NOD-SCID mice which has potential as a therapeutic target for KSHV-associated B-cell lymphomas.

  1. The urokinase receptor (uPAR facilitates clearance of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Joppe W R Hovius

    2009-05-01

    Full Text Available The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR; however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity and PAI-1 (high fibrinolytic activity knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1beta mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system.

  2. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation

    Science.gov (United States)

    Jha, Hem C.; Sun, Zhiguo; Upadhyay, Santosh K.; El-Naccache, Darine W.; Singh, Rajnish K.; Sahu, Sushil K.; Robertson, Erle S.

    2016-01-01

    Studies have suggested that Epithelial–Mesenchymal Transition (EMT) and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein) is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA) encoded by Kaposi's Sarcoma associated herpesvirus (KSHV) regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition) during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies. In this study, we demonstrate that Par3 is significantly up-regulated in KSHV-infected primary B-cells. Further, Par3 interacted with LANA in KSHV positive and LANA expressing cells which led to translocation of Par3 from the cell periphery to a predominantly nuclear signal. Par3 knockdown led to reduced cell proliferation and increased apoptotic induction. Levels of SNAIL was elevated, and E-cadherin was reduced in the presence of LANA or Par3. Interestingly, KSHV infection in primary B-cells led to enhancement of SNAIL and down-regulation of E-cadherin in a temporal manner. Importantly, knockdown of SNAIL, a major EMT regulator, in KSHV cells resulted in reduced expression of LANA, Par3, and enhanced E-cadherin. Also, SNAIL bound to the promoter region of p21 and can regulate its activity. Further a SNAIL inhibitor diminished NF-kB signaling through upregulation of Caspase3 in KSHV positive cells in vitro. This was also supported by upregulation of SNAIL and Par3 in BC-3 transplanted NOD-SCID mice which has potential as a therapeutic target for KSHV-associated B-cell lymphomas. PMID:27463802

  3. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  4. Triamcinolone-assisted Pars Plana Vitrectomy for Retinal Disease

    Institute of Scientific and Technical Information of China (English)

    Yuping Zheng; Naixue Sun; Quanchen Xiong; Xiaohua Wang; Yanlong Quan

    2005-01-01

    Purpose:To determine whether triamcinolone acetonide (TA)staining facilitates posterior hyaloid removal in patients undergoing pars plana vitrectomy (PPV) for retinal disease.Methods: A triamcinolone acetonide(TA)-assisted vitrectomy was performed on patients with the following disease: proliferative diabetic retionpathy(5eyes), central retinal vein occlusion(5eyes), macuar hole (3eyes), and epiretinal membrane(2eyes). Eyes without apparent preoperative posterior vitreous detachment were enrolled in this study. After a core PPV, TA aqueous suspension (40 mg/ml) was injected into the mid vitreous cavity to visualize the posterior hyaloid, thus allowing a complete posterior hyaloid separation and removal. The visual acuity, intraocular pressure (IOP), tamponade, corneal pathology, after-cataract, vitreous hemorrhage, and necessity for reoperation were thereafter examined for at least 3 months after surgery.Results: In all patients, the vitreous body was clearly seen by means of triamcinolone during surgery, and complete removal of posterior hyaloid was facilitated and confirmed.Retina was attached in 14 of 15 eyes, and vision acuity was improved in 9 of 15 eyes.Two eyes showed transient postoperative IOP elevation, 2 eyes had after cataract formation and 1eye had cataract progression. Vitreous hemorrhage occurred in 1 eye. No eye had corneal pathology.Conclusion: Triamcinolone improved the visibility of the hyaloid and the safety of surgical procedures during PPV. No obvious adverse effect due to toxicity of TA accrued in TA-assisted PPV.

  5. Phacoemulsification and pars plana vitrectomy: A combined procedure

    Directory of Open Access Journals (Sweden)

    Jain Vandana

    2007-01-01

    Full Text Available Aim: To describe the results of a combined procedure including phacoemulsification, insertion of posterior chamber intraocular lens (PCIOL and pars plana vitrectomy (PPV in eyes with vitreoretinal pathology and coexisting significant cataract. Design: Retrospective, consecutive, noncomparative, interventional case series. Materials and Methods: Medical records of patients who had undergone phacoemulsification, PPV and PCIOL implantation as a combined procedure between January 2000 and December 2004 were retrospectively reviewed. The main outcome measures were the anatomical success of retina, defined as reattached retina, intraoperative and postoperative complications and functional success in terms of final best corrected visual acuity. Results: In all, 65 eyes of 64 patients were included. The mean age of the patients was 50.9 years ± 17.1 (range, five to 82 years. Vitreous hemorrhage with or without retinal detachment (19 eyes, 29.2% was the most common indication for the vitreoretinal procedure. Primary anatomical success of retina was achieved in 59 eyes (90.7%. Visual acuity improved in 48 eyes (73.8%, was unchanged in 12 eyes (18.5% and deteriorated in five eyes (7.7%. Postoperative inflammation was significantly more in the subgroup of previously vitrectomized eyes (42% ( P =0.014, Fisher exact test compared to those which underwent primary vitrectomy. Conclusions: Combined surgery is a feasible option for patients with vitreoretinal diseases and cataract.

  6. Epidémie de la mort par surmenage ?

    Institute of Scientific and Technical Information of China (English)

    孔冰逸

    2011-01-01

    Ces derniers jours,on parle beaucoup de la mort par surmenage.Une série de disparitions de personnes travaillant dans le domaine de la communication fait réfléchir beaucoup de gens sur leur état de santé et sur la pression au travail.Est-ce une épidémie ? On·commence à s'en inquiéter,car on pense que ces décès sont dus au surmenage.Le 23 mai,Liu Jianfa,un jeune homme de 28 ans,a succombé à un infarctus aigu du myocarde.En tant que té1éporter de la cha(i)ne des sciences politiques et juridiques de la Té1évision de Zhengzhou,il travaillait beaucoup.Le temps d'un repos suffisant était comme mission impossible.Une semaine avant sa mort,il a écrit dans son micro-blog:《 Mon état de santé est grave.》 Mais son message suivant concerne encore le travail:《 Où va-t-on demain pour finir les t(a)ches ? 》

  7. Los parásitos de los animales domésticos.

    OpenAIRE

    Cruz B. Luis

    2012-01-01

    Desde el año 1937, el Departamento Nacional de Agricultura, desean prestar un servicio más efectivo para el agricultor costarricense, viene publicando en su Revista Agrícola, artículos referentes a los parásitos que infestan nuestro ganados e incluyendo siempre las medidas más prácticas para su control. Durante muchos años, los parásitos de los animales han constituido un verdadero flagelo para la industria costarricense, entorpeciendo su progreso; pero desde que el Servicio de Par...

  8. Pars plana cicatrization of sewn-in posterior chamber intraocular lens haptics.

    Science.gov (United States)

    McDermott, M L; Puklin, J E

    1997-03-01

    The authors describe the unexpected finding of cicatrization of posterior chamber lens haptics to the pars plana. This was found during removal of a secondary, transscleral sewn-in pseudophakos during a retinal reattachment procedure. Ophthalmic history and intraoperative photography revealed pars plana cicatrization of haptics. Despite removal of trans-scleral prolene fixation sutures and application of gentle traction, the posterior chamber lens haptics remained firmly adherent to pars plana retina. The haptics were amputated to prevent significant chorioretinal damage. The conventional belief that all sewn-in posterior chamber intraocular lenses cause little or no scarring response around the haptics may be unfounded.

  9. Effect of pre-drying and par-frying conditions on the crispness of French fries

    OpenAIRE

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all samples. Crispness was evaluated with a sensory panel. Furthermore, samples were analysed with a texture analyser and with confocal scanning laser microscopy (CSLM). Par-frying at 180 °C resulted in a c...

  10. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  11. Sécurité et immigration : vers une gouvernementalité par linquiétude ?

    OpenAIRE

    Bigo, Didier

    2006-01-01

    L'immigration est lue à travers le prisme de la sécurité par certains hommes politiques, par les polices et certains services sociaux, par nombre de journalistes et une fraction de l'opinion publique. Malgré les critiques fréquentes et argumentées d'une telle perception, malgré l'existence de discours alternatifs, cette lecture continue, très largement, d'être dominante. Pourquoi ? Qu'est ce qui pousse tous ces acteurs à faire un lien entre crime, chômage, terrorisme, fanatisme et migration ?...

  12. Downregulation of uPAR and Cathepsin B Retards Cofilin Dephosphorylation

    OpenAIRE

    Christopher S Gondi; Kandhukuri, Neelima; Kondraganti, Shakuntala; Gujrati, Meena; Olivero, William C.; Dinh, Dzung H.; Rao, Jasti S.

    2006-01-01

    Cathepsin B and uPAR play key roles in cancer cell migration and invasion. Here, we demonstrate that the simultaneous, siRNA-mediated downregulation of uPAR and cathepsin B inhibits glioma cell migration and is accompanied by cytoskeletal condensation. We show that the dephosphorylation of cofilin is inhibited by the downregulation of uPAR alone and, to a lesser extent, by the downregulation of cathepsin B alone, and that the effect was much higher by the downregulation of both molecules by p...

  13. Synthesis of nano-particles by soft chemistry: structural, morphological and dimensional control. Studies of the electrochemical properties (towards dyes solar cells); Synthese de nanoparticules par chimie douce: controle structural, morphologique et dimensionnel. Etudes des proprietes electrochimiques (vers les cellules solaires a colorants)

    Energy Technology Data Exchange (ETDEWEB)

    Cassaignon, S.; Koelsch, M.; Jolivet, J.P. [Paris-6 Univ. Pierre et Marie Curie, Chimie de la Matiere Condensee de Paris, CNRS UMR 7574, 75 - Paris (France)

    2006-07-01

    In this work are described the electrochemical behaviour of different TiO{sub 2} films (anatase, brookite and rutile) in aqueous solution and the influence of the parameters as the crystal structure and the morphology on the electrochemical answer. To complete this study, the capacity of the double layer has been measured by impedance spectroscopy. Voltage measurements of TiO{sub 2} sensitized by a dye will allow to discuss the reversibility of the system and the rearrangement mechanisms. At last, the influence of the nature of the TiO{sub 2} particles (anatase, rutile and brookite) on the photovoltage has been studied in order to estimate their interest for photovoltaic devices. (O.M.)

  14. L’hypertension artérielle et les désordres vasculaires induits par l'érythropoïétine recombinante humaine et le système rénine-angiotensine-aldostérone : Effet de l’exercice et des cellules T régulatrices

    OpenAIRE

    Barhoumi, Tlili,

    2011-01-01

    Hypertension (HTN) is one of the most frequent disease and is of greatest concern in Western countries.HTN is often associated with overweight, kidney, heart and endocrine system disease. Vasculardisorders, associated with HTN induced by erythropoietin (r-HuEPO) treatment in chronic kidneydisease or in case of disruption of the renin-angiotensin-aldosterone system (RAAS), associated increasein arterial stiffness, endothelial dysfunction, unbalanced endothelin-1/nitric oxide ratio (ET-1/NO) an...

  15. In vitro modulation of radiation-induced FAS-related apoptosis in CD34{sup +} progenitor cells by combination cytokines; Reduction de l'apoptose radio-induite impliquant le recepteur FAS au niveau des cellules hematopoietiques CD34{sup +} par une combinaison de cytokines

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Soutif, A.; Herodin, F

    1998-07-01

    Combination cytokines such as SCF, Flt-3 ligand, IL-3 and thrombopoietin can modulate Fas mRNA expression by in vitro irradiated CD34{sup +} cells which results in a moderate decrease of apoptotic ratio and an improved rate of clonogenicity of the irradiated progenitors. (authors)

  16. Himert: industrial calibration of type S, B and C thermocouples by comparison to metal - carbon eutectic cells: interest and perspectives; Etalonnage industriel de couples thermoelectriques type S, B et C par comparaison a des cellules eutectiques metal - carbone: interet et perspective

    Energy Technology Data Exchange (ETDEWEB)

    Fourrez, S.; Bailleul, G. [Thermocoax SASn 61 - Flers (France); Morice, R. [Laboratoire National de Metrologie et d' Essais (LNE), 75 - Paris (France); Machin, G. [National Physical Lab., Teddington (United Kingdom)

    2003-07-01

    For a long time temperature calibration laboratories have calibrated temperature sensors (resistance thermometers and thermocouples) by comparison to fixed point cells (between 0 deg C to 961.78 deg C) or by comparison to standard sensors in an homogenous and stable environment. For the calibration by comparison to fixed point cells uncertainties are small enough and almost satisfy industrials needs. Uncertainties become more important for calibration by comparison at high temperature (> 1000 deg C). Due to the standard calibration uncertainties it is very difficult for calibration laboratories to guaranty class 1 for the type R and S thermocouples up to 1600 deg C. Moreover calibration of type C thermocouples (Tungsten-Rhenium) up to 2000 deg C can not be performed by industrial laboratories. Metal-Carbon eutectic cells which will be developed during the HIMERT project, will help to reduce these uncertainties and at the same time will offer primary and industrial laboratories new calibration facilities. In addition Metal-Carbon eutectic cells can also be made into blackbody sources. These can be used to greatly improve traceability to industry and help difficult industrials measurement problems such as process control while viewing through continually contaminating windows. (authors)

  17. Air breath control radiotherapy in severe insufficiency respiratory patients with N.S.C.L.: application for deformable registration method in thoracic radiotherapy; Radiotherapie avec blocage respiratoire pour les grands insuffisants respiratoires atteints d'un carcinome pulmonaire non a petites cellules (Protocole RESPI 2000): application a la modelisation des deformations d'organes par recalage deformable

    Energy Technology Data Exchange (ETDEWEB)

    Sarrut, D.; Pommier, P.; Carrie, C. [Centre Leon-Berard, Dept. de Radiotherapie, CREATIS, Unite CNRS 5515, Inserm 630, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, Dept. de Biostatistique, 69 - Lyon (France)

    2006-11-15

    Purpose. Using deformable registration methods from a phase two clinical study of air breath control during radiotherapy in patients suffering from severe respiratory insufficiency and non-small cell lung carcinoma. Patients and methods, Between April 2002 and November 2005, 22 patients with severe respiratory insufficiency were treated with curative intent by conformal therapy combined with active breathing control. Results. After a mean of follow-up of 22 months, the local control rate is 28% and the method is feasible despite the severe respiratory insufficiency. However the overall survival is still poor due to metastatic widespread. For the second part of the study, the clinical protocol was also used for two studies using deformable registration methods. In the first study, a deformable registration method has been developed in order to register several breath-hold 3D CT of the same patient acquired at several days of interval. It allowed quantifying the inter-fraction breath-hold reproducibility by analysing the resulting displacement field. For 6 patients, the breath-hold was effective, while for 2 patients, motion greater than 10 mm were detected. The second study aimed to simulate 4D images from 3D breath-hold images. Developing an ad-hoc methodology based on the interpolation of 3D dense deformation fields performed it. The approach has been validated with expert selected landmarks, with accuracy lower than 3 mm. Conclusion. ABC is feasible, even in case of severe insufficiency respiratory syndrome but metastatic widespread disease is still a major challenge even with an acceptable local control rate without serious side effects: regarding the deformable registration method. Such artificial 4D images could allow decreasing the dose need to acquire a full 4D image, to simulate irregular breathing pattern and to be used for 4D dosimetry planning. (author)

  18. Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

    Directory of Open Access Journals (Sweden)

    F. de la Torre Silva

    2008-01-01

    Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.

  19. Modélisation 3D d'objets par un capteur visuel déplacé par un opérateur

    OpenAIRE

    Coudrin, Benjamin; Devy, Michel; Brethes, Ludovic; ORTEU, Jean-José

    2009-01-01

    Nous évoquons dans cet article, la problématique de la modélisation 3D d'un objet par un capteur visuel déplacé manuellement par un opérateur. L'objet est posé sur un plan : l'opérateur déplace le capteur sur une demi-sphère centrée sur l'objet. Plusieurs fonctions doivent être développées pour construire un modèle par ce procédé : acquisitions 2D et 3D, estimation des déplacements du capteur à partir des points suivis dans la séquence d'images 2D et recalage des données 3D acquises en chaque...

  20. Modélisation 3D d'objets par un capteur visuel déplacé par un opérateur

    OpenAIRE

    Coudrin, Benjamin; Devy, Michel; Brethes, Ludovic; Orteu, Jean-José

    2009-01-01

    National audience Nous évoquons dans cet article, la problématique de la modélisation 3D d'un objet par un capteur visuel déplacé manuellement par un opérateur. L'objet est posé sur un plan : l'opérateur déplace le capteur sur une demi-sphère centrée sur l'objet. Plusieurs fonctions doivent être développées pour construire un modèle par ce procédé : acquisitions 2D et 3D, estimation des déplacements du capteur à partir des points suivis dans la séquence d'images 2D et recalage des données ...

  1. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian;

    2010-01-01

    -suPAR), thereby exploring the possibility of replacing the blood sample with an easy obtainable urine sample. We enrolled 1,007 adults, older than 15 years of age, with a negative TB diagnosis between April 2004 and December 2006. Levels of U-suPAR and P-suPAR were available in 863 individuals. U......-suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  2. Average of peak-to-average ratio (PAR) of IS95 and CDMA2000 systems-single carrier

    OpenAIRE

    Lau, VKN

    2001-01-01

    Peak-to-average ratio (PAR) of a signal is an important parameter. It determines the input backoff factor of the amplifier to avoid clipping and spectral regrowth. We analyze and compose the PAR of the downlink signal for IS95 and the CDMA2000 single-carrier systems. It is found that the PAR of the transmitted signal depends on the Walsh code assignment. Furthermore, we found that the PAR of CDMA2000 signal is always lower than the IS95 signal. Finally, PAR control by Walsh code selection is ...

  3. Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2.

    OpenAIRE

    Easter, C L; Sobecky, P A; Helinski, D. R.

    1997-01-01

    A 3.2-kb region of the broad-host-range plasmid RK2 has been shown to encode a highly efficient plasmid maintenance system that functions in a vector-independent manner. This region, designated par, consists of two divergently arranged operons: parCBA and parDE. The 0.7-kb parDE operon promotes plasmid stability by a postsegregational killing mechanism that ensures that plasmid-free daughter cells do not survive after cell division. The 2.3-kb parCBA operon encodes a site-specific resolvase p...

  4. Material influence on biocontamination level and adhering cell physiology Influence des matériaux sur le niveau de biocontamination et la physiologie des cellules adhérentes

    Directory of Open Access Journals (Sweden)

    Allion Audrey

    2013-11-01

    Full Text Available Dans la plupart des environnements, les microorganismes vivent préférentiellement au sein de biofilms. De nombreux facteurs influencent leur formation i.e. les nutriments, la température, le régime du fluide environnent, la microflore et les matériaux. Dans le mécanisme de biocontamination, décrit en quatre étapes successives, l'adhésion initiale est un élément clé de la bioadhésion et les matériaux un élément majeur pour son contrôle. L'acier inoxydable est très utilisé dans de nombreux secteurs d'activité pour sa bonne nettoyabilité et son excellente résistance à la corrosion. Pour se différencier, certains matériaux mettent en avant d'autres propriétés. Ainsi, la sélection du matériau le mieux adapté à un problème donné nécessite de connaitre son aptitude à la biocontamination ainsi que son impact sur la physiologie des microorganismes. Pour tous les matériaux testés, la mortalité des bactéries adhérentes est inférieure à 55 %. Les résultats obtenus ont montré qu'un matériau dit antimicrobien n'induit pas plus de cellules endommagées comparativement aux autres matériaux. In most environments, association with a surface in a structure known as a biofilm is the prevailing microbial lifestyle. Several factors may influence the biofilm formation e.g. nutrients, temperature, flow velocity, initial microflora and the nature of materials. Considering the biocontamination mechanism described in four steps, the initial adhesion is a key element in the biocontamination phenomenon and the substratum is of major concern in controlling bacterial adhesion. Stainless steel is well used in numerous markets because of its high cleanability and corrosion resistance properties. However, other materials are put forward by focusing on properties which differentiate them from those of stainless steel. Thereby, to select the material best suited to the problem, there should have data on their aptitude for

  5. A clinical study on the therapeutic effect of rituximab in combination with autologous peripheral blood stem cell transplantation in treatment of CD20+ B cellulous non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Yong-sheng CHEN

    2013-07-01

    Full Text Available Objective To investigate the therapeutic effect of autologous peripheral blood stem cell transplantation (APBSCT in combination with rituximab in treatment of CD20+ B cellulous non-Hodgkin's lymphoma (B-NHL. Methods Sixty patients with CD20+ aggressive or refractory and recurrent B-NHL and treated with APBSCT in our department from Jan. 2005 to Jan. 2011 were admitted. All the subjects were divided into 2 groups according to their own choice: 25 patients received rituximab treatment (treatment group and 35 patients were treated without rituximab treatment (control group. All patients underwent chemotherapy and APBSCT. For patients in treatment group, rituximab was used with CHOP before collecting the stem cells and after the transplantation. After transplantation, rituximab and IL-2 were used in treatment group every 3-6 months as maintenance treatment. Results No side effect was observed during the use of rituximab either before or after transplantation. The mononuclear cell count in treatment and control group was (8.2±2.9×108/kg and (8.4±3.9×108/kg (P=0.822, respectively; CD34+cell count was (12.3±12.7×106/kg and (13.2±13.9×106/kg (P=0.799, respectively. Haemopoiesis reconstruction was successfully achieved in the patients of treatment group, while 3 patients in control group failed to have haemopoiesis reconstruction. No significant difference was found between two groups on the recovery time of neutrophilic granulocytes and platelets. All patients achieved complete remission. The average follow-up time was 22 months. The disease relapsed in two patients in treatment group and six in control group. The 3-year overall survival rate in treatment group (91.6% was a little higher than that in control group (69.5%, P=0.060. Conclusion To patients of CD20+ B lymphoma, the use of rituximab shows no side effect before or after collection of stem cell and hemopoiesis reconstruction, and the overall survival rate may be improved.

  6. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of abou...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....

  7. Controle social em saúde: o caso do Pará Social control in health: Pará's case

    OpenAIRE

    Solange Conceição Albuquerque de Cristo

    2012-01-01

    Este artigo objetiva contribuir para um exame mais circunstanciado das experiências de controle social. De acordo com o Cadastro dos Conselhos Municipais de Saúde no Brasil (2006), quase um terço da presidência dos Conselhos de Saúde no Pará é ocupada por representantes do segmento dos usuários. As análises desenvolvidas, a partir de entrevistas realizadas com presidentes de dois conselhos no Pará, permitiram compreender os desafios que os Conselhos de Saúde vêm enfrentando para participar da...

  8. Two new biting midges from Pará, Brazil (Diptera: Ceratopogonidae

    Directory of Open Access Journals (Sweden)

    Rosimeire Lopes da Trindade

    2011-02-01

    Full Text Available Two new species of Culicoides Latreille of the subgenus Haematomyidium Goeldi are described and illustrated based on female specimens from Pará, Brazil. The new species are compared with their similar congeners.

  9. PAR-Aware Large-Scale Multi-User MIMO-OFDM Downlink

    CERN Document Server

    Studer, Christoph

    2012-01-01

    We investigate an orthogonal frequency-division multiplexing (OFDM)-based downlink transmission scheme for large-scale multi-user (MU) multiple-input multiple-output (MIMO) wireless systems. The use of OFDM causes a high peak-to-average (power) ratio (PAR), which necessitates expensive and power-inefficient radio-frequency (RF) components at the base station. In this paper, we present a novel downlink transmission scheme, which exploits the massive degrees-of-freedom available in large-scale MU-MIMO-OFDM systems to achieve low PAR. Specifically, we propose to jointly perform MU precoding, OFDM modulation, and PAR reduction by solving a convex optimization problem. We develop a corresponding fast iterative truncation algorithm (FITRA) and show numerical results to demonstrate tremendous PAR-reduction capabilities. The significantly reduced linearity requirements eventually enable the use of low-cost RF components for the large-scale MU-MIMO-OFDM downlink.

  10. ANALYSES EXPERIMENTALES ET NUMERIQUES DU PROCEDE DE SOUDAGE PAR FRICTION MALAXAGE FSW

    OpenAIRE

    Lorrain, Olivier

    2010-01-01

    Le soudage par friction malaxage FSW est un procédé de soudage à l'état solide, sans fusion du matériau. La soudure est réalisée par l'action d'un outil composé d'un épaulement et d'un pion positionné à l'interface des deux pièces à souder. L'outil a deux rôles : échauffement de la matière par frottement de l'épaulement, malaxage de la matière par l'intermédiaire du pion. Ce travail de thèse s'inscrit dans le cadre d'un partenariat entre Arts et Métiers ParisTech et l'Institut de Soudure. Son...

  11. Inmunidad frente a infecciones: bacterias, virus, hongos y parásitos

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco de la Calle, Francisco Manuel; Vázquez Araujo, Begoña

    2012-01-01

    Respuesta inmune frente a la infección: Bacterias extracelulares, bacterias intracelulares, hongos, virus, parásitos. Inmunidad innata, inmunidad adaptativa, mecanismos de evasión, consecuencias perjudiciales de la respuesta inmune.

  12. 25-Gauge pars plana vitrectomy for ciliary block (malignant) glaucoma.

    Science.gov (United States)

    Meng, Li; Wei, Wenbin; Li, Yanlong; Hui, Xiaoying; Han, Xiaodong; Shi, Xiaobo

    2015-08-01

    To evaluate the efficacy of 25-ga pars plana vitrectomy (PPV) and 25-ga PPV combined with phacoemulsification surgery for managing ciliary block (malignant) glaucoma. The medical records of 11 eyes, in nine consecutive patients with malignant glaucoma were retrospectively reviewed to determine the efficacy of 25-ga PPV for alleviating this disease. All phakic eyes underwent phacoemulsification surgery during vitrectomy. Control of intraocular pressure (IOP), pre- and postoperative best-corrected visual acuity (BCVA), and development of intra- and postoperative complications were evaluated during follow-up. Malignant glaucoma was promptly resolved, and recurrence was not observed during a mean follow-up period of 12.7 ± 3.2 (range 6-18) months. The mean IOP decreased from 35.9 ± 2.9 mmHg, preoperatively, to 16.0 ± 1.4 mmHg, measured at last visit (P = 0.013). Although IOP control was achieved in all eyes after surgery, two eyes required long-term topical antiglaucoma medication. The mean logarithm of the minimum angle of resolution BCVA improved from +0.69 ± 0.11, preoperatively, to +0.29 ± 0.07, postoperatively (P = 0.027). No severe intraoperative complications were observed. Postoperative complications mostly occurred during the first week after surgery, including transient corneal edema and Descemet's membrane folds in three eyes, fibrotic exudation in 2, local iris posterior synechia in 1, and transient hypotony in 1, which were resolved spontaneously or with medication. The 25-ga PPV procedure seems to be safe and effective for treating malignant glaucoma. Combined vitrectomy with phacoemulsification surgery and a staged surgical approach may improve the success rate. PMID:25062710

  13. Unitary synaptic connections among substantia nigra pars reticulata neurons.

    Science.gov (United States)

    Higgs, Matthew H; Wilson, Charles J

    2016-06-01

    Neurons in substantia nigra pars reticulata (SNr) are synaptically coupled by local axon collaterals, providing a potential mechanism for local signal processing. Because SNr neurons fire spontaneously, these synapses are constantly active. To investigate their properties, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from SNr neurons in brain slices, in which afferents from upstream nuclei are severed, and the cells fire rhythmically. The sIPSC trains contained a mixture of periodic and aperiodic events. Autocorrelation analysis of sIPSC trains showed that a majority of cells had one to four active unitary inputs. The properties of the unitary IPSCs (uIPSCs) were analyzed for cells with one unitary input, using a model of periodic presynaptic firing and stochastic synaptic transmission. The inferred presynaptic firing rates and coefficient of variation of interspike intervals (ISIs) corresponded well with direct measurements of spiking in SNr neurons. Methods were developed to estimate the success probability, amplitude distributions, and kinetics of the uIPSCs, while removing the contribution from aperiodic sIPSCs. The sIPSC amplitudes were not increased upon release from halorhodopsin silencing, suggesting that most synapses were not depressed at the spontaneous firing rate. Gramicidin perforated-patch recordings indicated that the average reversal potential of spontaneous inhibitory postsynaptic potentials was -64 mV. Because of the change in driving force across the ISI, the unitary inputs are predicted to have a larger postsynaptic impact when they arrive late in the ISI. Simulations of network activity suggest that this very sparse inhibitory coupling may act to desynchronize the activity of SNr neurons while having only a small effect on firing rate. PMID:26961101

  14. La relecture du romancero par les vihuelistes de la Renaissance

    Directory of Open Access Journals (Sweden)

    Pascal Martel

    1999-01-01

    Full Text Available Les romances espagnols de la Reconquête relataient sur le mode épique des faits passés sur une mélodie récurrente qui servait surtout d’outil mnémotechnique pour réciter de longues narrations. Lorsque Diego Pisador reprend un romance, il n’en prend que quelques vers : du coup, le rapport entre les mots et les notes se fait plus étroit. D’un poème épique, il élabore une amplification lyrique, une véritable composition musicale, opère un véritable changement d’esthétique : le passage de la longue narration sur un thème musical bref et récurrent qui caractérisait le romance médiéval de la Reconquista, à une forme musico-littéraire plus brève mais plus élaborée, propre à introduire la vibration lyrique dans la matière épique. Familier de la Cour, il entend ainsi servir les desseins politiques de Philippe Il à qui il dédie son œuvre : le compositeur vihueliste qu’était Pisador en effet participe à l’effort de l’intégration du Maure poursuivi par la politique de la Maison d’Autriche. Mais les noces n’eurent pas lieu et les Maures furent au contraire expulsés en 1609. L’analyse de cette chanson nous donne l’occasion de découvrir les moyens employés par le musicien pour se livrer à une véritable amplification lyrique d’un simple récit par la musique. La chanson savante n’est pas non plus une composition dans laquelle la mélodie traduirait simplement en musique le texte poétique de façon tout à fait parallèle : la musique n’est pas qu’une répétition, sous une autre forme, de la parole, ou bien l’image sonore d’un texte. Musique et poésie constituent deux moyens autonomes d’expression mais qui, dans une chanson, concourent à un même but : ces deux moyens d’expression tantôt se rejoignant, tantôt s’émancipant l’un de l’autre, de sorte que le propre de la chanson réside justement dans cette tension constante entre ses deux composantes. La mise en musique

  15. Developpement de techniques de diagnostic non intrusif par tomographie optique

    Science.gov (United States)

    Dubot, Fabien

    Que ce soit dans les domaines des procedes industriels ou de l'imagerie medicale, on a assiste ces deux dernieres decennies a un developpement croissant des techniques optiques de diagnostic. L'engouement pour ces methodes repose principalement sur le fait qu'elles sont totalement non invasives, qu'elle utilisent des sources de rayonnement non nocives pour l'homme et l'environnement et qu'elles sont relativement peu couteuses et faciles a mettre en oeuvre comparees aux autres techniques d'imagerie. Une de ces techniques est la Tomographie Optique Diffuse (TOD). Cette methode d'imagerie tridimensionnelle consiste a caracteriser les proprietes radiatives d'un Milieu Semi-Transparent (MST) a partir de mesures optiques dans le proche infrarouge obtenues a l'aide d'un ensemble de sources et detecteurs situes sur la frontiere du domaine sonde. Elle repose notamment sur un modele direct de propagation de la lumiere dans le MST, fournissant les predictions, et un algorithme de minimisation d'une fonction de cout integrant les predictions et les mesures, permettant la reconstruction des parametres d'interet. Dans ce travail, le modele direct est l'approximation diffuse de l'equation de transfert radiatif dans le regime frequentiel tandis que les parametres d'interet sont les distributions spatiales des coefficients d'absorption et de diffusion reduit. Cette these est consacree au developpement d'une methode inverse robuste pour la resolution du probleme de TOD dans le domaine frequentiel. Pour repondre a cet objectif, ce travail est structure en trois parties qui constituent les principaux axes de la these. Premierement, une comparaison des algorithmes de Gauss-Newton amorti et de Broyden- Fletcher-Goldfarb-Shanno (BFGS) est proposee dans le cas bidimensionnel. Deux methodes de regularisation sont combinees pour chacun des deux algorithmes, a savoir la reduction de la dimension de l'espace de controle basee sur le maillage et la regularisation par penalisation de Tikhonov

  16. Pars Plana Ahmed Implantation Combined with 23-gauge Vitrectomy for Refractory Neovascular Glaucoma in Diabetic Retinopathy

    OpenAIRE

    Jeong, Hoon Seok; Nam, Dong Heun; Paik, Hae Jung; Lee, Dae Yeong

    2012-01-01

    Purpose To evaluate the efficacy and safety of a pars plana Ahmed valve implantation combined with 23-gauge sutureless vitrectomy in the treatment of patients with medically uncontrolled neovascular glaucoma (NVG) in proliferative diabetic retinopathy (PDR). Methods The authors retrospectively reviewed the records of 11 consecutive patients with refractory NVG in PDR who underwent a 23-gauge sutureless vitrectomy combined with pars plana placement of an Ahmed valve implant. Control of intraoc...

  17. Transconjunctival 25-gauge pars plana vitrectomy and internal limiting membrane peeling for chronic macular edema

    OpenAIRE

    Cho M; D'Amico DJ

    2012-01-01

    Minhee Cho, Donald J D'AmicoWeill Cornell Medical College, Department of Ophthalmology, New York, NY, USABackground: The purpose of this study was to investigate the visual and anatomic outcomes in patients with chronic macular edema who underwent 25-gauge pars plana vitrectomy with internal limiting membrane peeling.Methods: This study was a retrospective chart review of 24 eyes from 21 patients who underwent 25-gauge pars plana vitrectomy and indocyanine green-assisted internal limi...

  18. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  19. Negative Regulation of Neuromedin U mRNA Expression in the Rat Pars Tuberalis by Melatonin

    OpenAIRE

    Sayaka Aizawa; Ichiro Sakata; Mai Nagasaka; Yuriko Higaki; Takafumi Sakai

    2013-01-01

    The pars tuberalis (PT) is part of the anterior pituitary gland surrounding the median eminence as a thin cell layer. The characteristics of PT differ from those of the pars distalis (PD), such as cell composition and gene expression, suggesting that the PT has a unique physiological function compared to the PD. Because the PT highly expresses melatonin receptor type 1, it is considered a mediator of seasonal and/or circadian signals of melatonin. Expression of neuromedin U (NMU) that is know...

  20. ON THE PAR REDUCTION OF MB-OFDM ULTRA-WIDEBAND SIGNALS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The Peak to Average power Ratio (PAR) of a Multi-Band Orthogonal Frequency-Division Multi-plexing (MB-OFDM) Ultra-Wide Band (UWB) signals can be substantially larger than that of single carrieror carrier-less ultra-wideband signals. In this letter, a novel PAR reduction scheme for the MB-OFDM UWBsystem based on spreading and interleaving is proposed. By spreading the coded bits over each subcarrier incorresponding band and interleaving the spread symbols across all bands, the PAR statistics of theMB-OFDM signals can be improved and the PAR is reduced obviously. In the PAR reduction scheme, there isno loss in transmission data rate or Bit Error Rate (BER) performance decreasing. Since the spreading andinterleaving operation are implemented by unitary Hadamard sequences and used for an approach to providethe robustness of the UWB system to narrowband interference, there is no additional implementation burden.Simulation results show that the investigated scheme gives the PAR reduction of 3dB compared with that ofthe original MB-OFDM signals.

  1. Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist

    DEFF Research Database (Denmark)

    Ploug, Michael

    2013-01-01

    -function relationships in uPAR has been refined to such a level that a rational design of uPAR function as well as compounds specifically targeting defined functions of uPAR are now realistic options. This knowledge opens new avenues for developing therapeutic intervention regimens targeting uPAR as well...

  2. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-03-01

    Full Text Available [Français] L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté. [English] The use of the Web presented in this article supports a teaching approach based on knowledge sharing. Within the context of an industrial simulation, the students in an advanced programming course must learn to share their expertise, to communicate their questions clearly, to describe problems, and to deal with unexpected reversals. The Web becomes a collaborative space for disseminating the requests of a fictional client, along with directives, preliminary studies, and agreements. The results obtained tend to suggest that this global approach forces the student to plan better, increases the level of cooperation, facilitates the production of analogies, and invites the students to improve how they formulate and describe their problems. A system that facilitates the logistics of peer review (retrieving assignments, constructing an evaluation chart, and disseminating results is also presented.

  3. A Dual Mechanism Controls Nuclear Localization in the Atypical Basic-Helix-Loop-Helix Protein PAR1 of Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Anahit Galstyan; Jordi Bou-Torrent; Irma Roig-Villanova; Jaime F. Martínez-García

    2012-01-01

    PAR1 is an atypical basic-helix-loop-helix (bHLH) protein that negatively regulates the shade avoidance syndrome in Arabidopsis thaliana acting as a transcriptional cofactor.Consistently with this function,PAR1 has to be in the nucleus to display biological activity.Previous structure-function analyses revealed that the N-terminal region of PAR1 drives the protein to the nucleus.However,truncated forms of PAR1 lacking this region still display biological activity,implying that PAR1 has additional mechanisms to localize into the nucleus.In this work,we compared the primary structure of PAR1 and various related and unrelated plant bHLH proteins,which led us to suggest that PAR1 contains a non-canonical nuclear localization signal (NLS) in the N-terminal region.By overexpressing truncated and mutated derivatives of PAR1,we have also investigated the importance of other regions of PAR1,such as the acidic and the extended HLH dimerization domains,for its nuclear localization.We found that,in the absence of the N-terminal region,a functional HLH domain is required for nuclear localization.Our results suggest the existence of a dual mechanism for PAR1 nuclear localization:(1) one mediated by the N-terminal non-consensus NLS and (2) a second one that involves interaction with other proteins via the dimerization domain.

  4. ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA.

    Science.gov (United States)

    Hui, Monica P; Galkin, Vitold E; Yu, Xiong; Stasiak, Alicja Z; Stasiak, Andrzej; Waldor, Matthew K; Egelman, Edward H

    2010-03-01

    Most bacterial chromosomes contain homologs of plasmid partitioning (par) loci. These loci encode ATPases called ParA that are thought to contribute to the mechanical force required for chromosome and plasmid segregation. In Vibrio cholerae, the chromosome II (chrII) par locus is essential for chrII segregation. Here, we found that purified ParA2 had ATPase activities comparable to other ParA homologs, but, unlike many other ParA homologs, did not form high molecular weight complexes in the presence of ATP alone. Instead, formation of high molecular weight ParA2 polymers required DNA. Electron microscopy and three-dimensional reconstruction revealed that ParA2 formed bipolar helical filaments on double-stranded DNA in a sequence-independent manner. These filaments had a distinct change in pitch when ParA2 was polymerized in the presence of ATP versus in the absence of a nucleotide cofactor. Fitting a crystal structure of a ParA protein into our filament reconstruction showed how a dimer of ParA2 binds the DNA. The filaments formed with ATP are left-handed, but surprisingly these filaments exert no topological changes on the right-handed B-DNA to which they are bound. The stoichiometry of binding is one dimer for every eight base pairs, and this determines the geometry of the ParA2 filaments with 4.4 dimers per 120 A pitch left-handed turn. Our findings will be critical for understanding how ParA proteins function in plasmid and chromosome segregation.

  5. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Directory of Open Access Journals (Sweden)

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  6. Transcription factor network downstream of protease activated receptors (PARs modulating mouse bladder inflammation

    Directory of Open Access Journals (Sweden)

    Hurst Robert E

    2007-08-01

    Full Text Available Abstract Background All four PARs are present in the urinary bladder, and their expression is altered during inflammation. In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders. Methods For this purpose, we used a protein/DNA combo array containing 345 different TF consensus sequences. Next, the TF selected was validated by EMSA and IHC. As mast cells seem to play a fundamental role in bladder inflammation, we determined whether c-kit receptor deficient (Kitw/Kitw-v mice have an abrogated response to PAR stimulation. Finally, TFEB antibody was used for CHIP/Q-PCR assay and revealed up-regulation of genes known to be downstream of TFEB. Results TFEB, a member of the MiTF family of basic helix-loop-helix leucine zipper, was the only TF commonly up-regulated by all PAR-APs. IHC results confirm a correlation between inflammation and TFEB expression in C57BL/6 mice. In contrast, Kitw/Kitw-v mice did not exhibit inflammation in response to PAR activation. EMSA results confirmed the increased TFEB binding activity in C57BL/6 but not in Kitw/Kitw-v mice. Conclusion This is the first report describing the increased expression of TFEB in bladder inflammation in response to PAR activation. As TFEB belongs to a family of TFs essential for mast cell survival, our findings suggest that this molecule may influence the participation of mast cells in PAR-mediated inflammation and that targeting TFEB/MiTF activity may be a novel approach for the treatment of bladder inflammatory disorders.

  7. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  8. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily Kara

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  9. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  10. Simulation d'une structure générique RC-IGBT sans "tension de retournement" adaptée à l'intégration monolithique de cellules de commutation sur puce Si

    OpenAIRE

    Lale, Adem; Bourennane , Abdelhakim; El khadiry, Abdelilah; Richardeau, Frédéric

    2014-01-01

    Une structure IGBT à conduction inverse (RC- IGBT) qui intègre de manière monolithique un IGBT pour la conduction directe et un thyristor auto-amorçable pour la conduction inverse est proposée. Contrairement au RC-IGBT classique, cette nouvelle structure ne présente pas de snapback [1-2] en mode de conduction direct. Le fonctionnement du RC- IGBT que nous proposons a été étudié par des simulations physiques 2D en statique et en dynamique. La structure proposée est ensuite utilisée pour créer ...

  11. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  12. Infantile maxillary sinus osteomyelitis mimicking orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Nagarajan Krishnan

    2014-01-01

    Full Text Available Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococcus aureus growth and the child improved with intravenous cloxacillin therapy. This case is presented due to the rarity of its presentation in this age group and for awareness to consider this entity in children having fever and peri-orbital swelling.

  13. Infantile Maxillary Sinus Osteomyelitis Mimicking Orbital Cellulitis

    OpenAIRE

    Nagarajan Krishnan; Nathan Ramamoorthy; Suresh Panchanathan; Balasundaram, Jothiramalingam S

    2014-01-01

    Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococc...

  14. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature.

  15. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature. PMID:25763844

  16. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  17. Two-state conformational equilibrium in the Par-4 leucine zipper domain.

    Science.gov (United States)

    Schwalbe, Martin; Dutta, Kaushik; Libich, David S; Venugopal, Hariprasad; Claridge, Jolyon K; Gell, David A; Mackay, Joel P; Edwards, Patrick J B; Pascal, Steven M

    2010-08-15

    Prostate apoptosis response factor-4 (Par-4) is a pro-apoptotic and tumor-suppressive protein. A highly conserved heptad repeat sequence at the Par-4 C-terminus suggests the presence of a leucine zipper (LZ). This C-terminal region is essential for Par-4 self-association and interaction with various effector proteins. We have used nuclear magnetic resonance (NMR) spectroscopy to fully assign the chemical shift resonances of a peptide comprising the LZ domain of Par-4 at neutral pH. Further, we have investigated the properties of the Par-4 LZ domain and two point mutants under a variety of conditions using NMR, circular dichroism (CD), light scattering, and bioinformatics. Results indicate an environment-dependent conformational equilibrium between a partially ordered monomer (POM) and a predominantly coiled coil dimer (CCD). The combination of techniques used allows the time scales of the equilibrium to be probed and also helps to identify features of the amino acid sequence that may influence the equilibrium.

  18. Status of PAR Installation in Korean NPPs and Experiences in Regulatory Activities

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Jae; Sung, Key Yong [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2010-10-15

    Following TMI-2 and Chernobyl accidents, concerns on the safety problems of nuclear power plants (NPPs) have been increased, especially for severe accident phenomena including hydrogen risk. To reduce the potential of hydrogen combustion, much of international efforts have been made for decades and it resulted in development of an innovative device, i.e. passive autocatalytic recombiner (PAR), for hydrogen removal in containment during an accident. On the designing and implementing a PAR, Bachellerie et al. provided a good instruction. Actually not only most new NPP designs but also NPPs to be refurbished are considering the installation of PARs for hydrogen control following a design basis accident (DBA) and severe accident (SA). For some Korean NPPs, the utility, KHNP, also has decided to equip PARs in containment and KINS has performed relevant regulatory reviews and preoperational inspections. In this paper, the status of PAR installation in Korean NPPs and KINS' experiences in regulatory activities including onsite findings as well as some recommendations, are described

  19. Protease-activated receptors (PARs) in cancer: Novel biased signaling and targets for therapy.

    Science.gov (United States)

    Bar-Shavit, R; Maoz, M; Kancharla, A; Jaber, M; Agranovich, D; Grisaru-Granovsky, S; Uziely, B

    2016-01-01

    Despite the fact that G protein-coupled receptors (GPCRs) mediate numerous physiological processes and represent targets for therapeutics for a vast array of diseases, their role in tumor biology is under appreciated. Protease-activated receptors (PARs) form a family which belongs to GPCR class A. PAR1&2 emerge with a central role in epithelial malignancies. Although the part of PAR1&2 in cancer is on the rise, their underlying signaling events are poorly understood. We review hereby past, present, and future cancer-associated PAR biology. Mainly, their role in physiological (placenta-cytotophobalst) and patho-physiological invasion processes. The identification and characterization of signal pleckstrin homology (PH)-domain-binding motifs established critical sites for breast cancer growth in PAR1&2. Among the proteins found to harbor important PH-domains and are involved in PAR biology are Akt/PKB as also Etk/Bmx and Vav3. A point mutation in PAR2, H349A, but not R352A, abrogated PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumor growth in vivo as also placental extravillous trophoblast (EVT) invasion in vitro is markedly reduced. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind PH-domain, inhibits mammary tumors and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26928551

  20. Transmission and Distribution of Photosymthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7216-050] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  1. Transmission and Distribution of Photosynthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7226-270] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  2. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  3. L'offre d'information volontaire par Internet et le gouvernement des entreprises françaises

    OpenAIRE

    Li, Li

    2010-01-01

    (VF)Cette recherche analyse le phénomène de la diffusion d’information par Internet en France. En prolongeant les études antérieures sur l’offre volontaire d’information, nous cherchons à savoir comment les facteurs du gouvernement d’entreprise influent sur la communication par voie électronique. Nous examinons également l’impact des caractéristiques des entreprises sur la publication volontaire par Internet. Les résultats montrent que l’offre d’information par Internet s’accroît lorsque la s...

  4. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  5. Evaluation du risque de renversement de poids lourds par indice de fiabilité

    OpenAIRE

    Sellami, Yamine; Imine, Hocine; CADIOU, Jean Charles; ELHADRI, Abdelhafid

    2008-01-01

    Cet article présente une nouvelle méthode pour évaluer et prédire dynamiquement le risque de renversement de poids lourds par une approche fiabiliste. La méthode est basée sur la prise en compte des incertitudes du système. Les paramètres les plus influents sur le risque sont représentés par des variables aléatoires, alors que les variables dynamiques sont estimées par un filtre de Kalman Unscented, dédié aux systèmes non linaires. L'ensemble des variables aléatoires obtenues est utilisé pour...

  6. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  7. Excrétion de carbone organique par le phytoplancton lémanique

    OpenAIRE

    Feuillade, M.; Dufour, Philippe; Feuillade, J.; Pelletier, J P

    1986-01-01

    L'excrétion du carbone organique dissous par le phytoplancton du lac Léman a été évaluée par la méthode du 14C entre mars et novembre 1984. Elle varie entre 0,01 et 0,5 mgC.m-3.h-1 et dépend en premier lieu de la vitesse d'assimilation photosynthétique. L'excrétion carbonée oscille généralement entre 2 et 5% de l'assimilation carbonée et n'excède qu'exceptionnellement 6%. Les valeurs sont sous-estimées par la réassimilation hétérotrophe. L'excrétion nocturne représente moins de 10% des pertes...

  8. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter;

    2015-01-01

    The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated...... investigations have generated new and valuable biological information about the cell types being involved in tumour invasion and progression through the plasminogen activation system....

  9. Modélisation du procédé de soudage par points

    OpenAIRE

    Srikunwong, Chainarong

    2005-01-01

    Parmi les procédés de soudage, la simulation numérique du soudage par résistance électrique par points offre l'avantage d'un calcul direct des sources de chaleur par couplage électro-thermique. En revanche, les données nécessaires pour décrire les contacts sont rares et difficiles à mesurer. Comme pour les autres procédésde soudage, la difficulté principale en simulation numérique est la disponibilité de données d'entrée à toutes températures depuis l'ambiante jusqu'au-delà de la fusion. Le c...

  10. Helicophyllaceae (Bryophyta, nova ocorrência para o Estado do Pará, Brasil Helicophyllaceae (Bryophyta, a new record to Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina C. L. Lisboa

    2005-09-01

    Full Text Available Helicophyllaceae, família monotípica neotropical, é registrada pela primeira vez no Estado do Pará. Sua única espécie, Helicophyllum torquatum (Hook. Brid., registrada anteriormente no Estado do Amazonas e que recentemente havia sido excluída da lista de musgos amazônicos, é apresentada como nova ocorrência para toda a Amazônia brasileira.Helicophyllaceae, a monotypic family of Neotropics, is presented for the Pará State. Helicophyllum torquatum (Hook. Brid., the single species, was recorded for the Amazonas State, but recently was excluded of checklist of Amazonian mosses. H. torquatum is considered a new report for all Brazilian Amazônia.

  11. Correlación de parámetros geotécnicos con parámetros de un modelo hidrológico superficial.

    Directory of Open Access Journals (Sweden)

    Carlos Andres Caro Camargo

    2014-07-01

    Full Text Available Este artículo presenta la relación entre parámetros geotécnicos básicos y parámetros del modelo hidrológico de Thomas para balance hídrico de cuencas hidrográficas rurales. Esta relación funciona como una aplicación metodológica de calibración, herramienta útil en modelos distribuidos como es el caso de IBER, que representa un sistema distribuido de simulación numérica para flujo no permanente en lámina libre. Se realizó una exploración en 25 puntos (en 15 subcuencas de la cuenca de Rio de Piedras (Boyacá, obteniendo muestras de suelo a las cuales se les realizó caracterización geotécnica mediante ensayos de laboratorio.

  12. Analysis of some sepsis markers: C-reactive protein, Procalcitonin, Osteopontin and suPAR

    Directory of Open Access Journals (Sweden)

    Ilaria Crespi

    2010-09-01

    Full Text Available Sepsis appears to be due to an uncontrolled pro and anti-inflammatory response leading to organ dysfunction until shock and death.Accuracy of diagnosis and appropriate treatment affect the outcome. Aim of the study was to investigate if the levels of Osteopontin (OPN and Soluble Urokinase-type Plasminoge Activator Receptor (suPAR might be early markers of sepsis and if these markers play a role in predicting the progression to septic shock. Methods:The levels of OPN, suPAR, C-reactive protein (CRP and procalcitonin (PCT were measured in patients at higher risk of infection. The samples were collected from the day of admission for the following fifteenth day. During recovery Sistemic Inflammatory Response Syndrome (SIRS criteria, blood chemistry data, blood gas- analysis, lactate and diuresis were collected. Microbiological culture were performed according to the clinical condition. Results: 29 patients were enrolled in the study, including 14 subjects with positive blood cultures.The values of OPN, PCT, suPAR and CRP were significantly increased in patients with positive blood cultures than those with negative blood cultures.Analysing changes of the levels of OPN, suPAR, PCT and CRP in patients with septic shock, the values of OPN increased in advance to the clinical diagnosis of septic shock, while the values of suPAR and PCT slight delay compared to those OPN.The levels of CRP were independent from the onset of septic shock state. Conclusions: These preliminary data suggest that Osteopontin and suPAR can be used as early markers of sepsis and might be useful in monitoring of septic outcome to predict a possible evolution to septic shock.

  13. Relación entre la Deseabilidad Social y los parámetros del Modelo Logístico de tres parámetros

    Directory of Open Access Journals (Sweden)

    Facundo Abal

    2015-05-01

    Full Text Available El objetivo de este trabajo es estudiar la relación de los parámetros a , b y c del modelo logístico de tres parámetros y la tendencia de los individuos a atribuirse a sí mismo cualidades socialmente deseables. Participaron 1592 personas que respondieron las escalas Perseverancia y Distorsión del Big Five Questionnaire (BFQ. Se aplicó el ML3p a los ítems de perseverancia mediante el programa MULTILOG. Previamente se debieron eliminar 3 reactivos para cumplir con la condición de unidimensionalidad requerida por el modelo. Como la escala Likert de los ítems de perseverancia tiene 5 de alternativas se contemplaron diferentes procedimientos para establecer 4 condiciones de dicotomización de los datos. Los parámetros de los ítems se estimaron el procedimiento de Máxima Verosimilitud Marginal a Posteriori. El ajuste del ML3p fue adecuado para los 9 ítems analizados. Considerando las diferentes condiciones de dicotomización se identificaron entre 3 y 5 ítems de cuya respuesta clave se asoció a mayores niveles de Distorsión. Sin embargo, los resultados obtenidos no permiten concluir que la respuesta influida por la deseabilidad social repercuta sobre alguno de los parámetros estudiados. Se discuten las limitaciones del presente estudio y se comentan otras líneas de investigación que pueden guiar a futuros estudios.

  14. Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway

    OpenAIRE

    Dormoy, Valérian; Tormanen, Kati; Sütterlin, Christine

    2013-01-01

    The centrosome contains two centrioles that differ in age, protein composition and function. This non-membrane bound organelle is known to regulate microtubule organization in dividing cells and ciliogenesis in quiescent cells. These specific roles depend on protein appendages at the older, or mother, centriole. In this study, we identified the polarity protein partitioning defective 6 homolog gamma (Par6γ) as a novel component of the mother centriole. This specific localization required the ...

  15. Volume equation as basis of community forest management in Anapu, Pará State, Brazil

    OpenAIRE

    Wallacy Ferreira Barreto; Fábio Miranda Leão; Marlon Costa de Menezes; Deivison Venicio Souza

    2014-01-01

    The community forest management in settlement areas, in Pará, needs tools that provide reliable information about wood potential in the area, as volume equations. Five volumetric models of simple entrance and five of double entrance were adjusted to estimate the wood volume of standing trees in the Project of sustainable development Virola-Jatobá in Anapu, Pará State, Brazil. The trees were cubed using Smalian method. The diameter at 1.3 m above soil level was measured in 172 individuals from...

  16. Propuesta de registro fonológico en personas adultas con parálisis cerebral

    OpenAIRE

    Revuelta Carpintero, Sara Fátima

    2015-01-01

    El presente trabajo refiere la creación de un registro fonológico dirigido a la población adulta con parálisis cerebral. Esta patología muestra, aparte de otros síntomas, una deficiencia en el proceso articulatorio del lenguaje, ya que presentan muchas dificultades a nivel motor y/o sensorial, cursando con espasticidad, atetosis, ataxia o la unión de éstos. Es importante reflejar la asociación existente entre la parálisis cerebral y los trastornos articulatorios, los cuales son un...

  17. PARma: identification of microRNA target sites in AGO-PAR-CLIP data.

    Science.gov (United States)

    Erhard, Florian; Dölken, Lars; Jaskiewicz, Lukasz; Zimmer, Ralf

    2013-01-01

    PARma is a complete data analysis software for AGO-PAR-CLIP experiments to identify target sites of microRNAs as well as the microRNA binding to these sites. It integrates specific characteristics of the experiments into a generative model. The model and a novel pattern discovery tool are iteratively applied to data to estimate seed activity probabilities, cluster confidence scores and to assign the most probable microRNA. Based on differential PAR-CLIP analysis and comparison to RIP-Chip data, we show that PARma is more accurate than existing approaches. PARma is available from http://www.bio.ifi.lmu.de/PARma. PMID:23895117

  18. Élimination des micropolluants par les stations d'épuration domestiques

    OpenAIRE

    Choubert, J.M.; Pomies, M.; Miège, C.; Martin Ruel, S.; Budzinski, H.; Wisniewski, C.; Coquery, M.

    2012-01-01

    Les stations d'épuration domestiques n'ont pas été conçues pour traiter les micropolluants. Elles en éliminent cependant une quantité non négligeable, essentiellement par sorption sur les boues, associée à une dégradation par voie biologique pour certaines substances. Cet article synthétise les principaux acquis récents concernant le comportement des micropolluants dans les filières de traitement des eaux (primaires, secondaires, tertiaires) et dans les filières boues associées. Il présente é...

  19. Capacidad de salto en futbolistas con parálisis cerebral

    OpenAIRE

    Yanci, J; Los Arcos, A.; Grande, I.; Santalla, A; Figueroa, J; Gil, E.; Cámara, J.

    2014-01-01

    Los objetivos del presente estudio fueron determinar en jugadores de fútbol con parálisis cerebral la altura de vuelo durante la realización del salto sin contramovimiento y con contramovimiento, y observar la relación de las variables antropométricas y de la clase funcional con la altura de vuelo y con el índice elástico. Trece jugadores de fútbol 7 diagnosticados con parálisis cerebral participaron en el estudio. La altura de vuelo durante el salto sin contramovimiento (20.45±4.45 cm) y con...

  20. Le Sycoscan : un système d'inspection des conteneurs par balayage radioscopique

    CERN Multimedia

    Krystal Production

    1997-01-01

    La société Europ Scan, le port autonome du Havre et les douanes françaises ont conçu un système de contrôle par rayons X qui permet d’étudier par radiographie le contenu d'un chargement. Les conteneurs sont ainsi vérifiés sans être déchargés ou ouverts. On utilise des faisceaux de rayons X de faible énergie couplés à des détecteurs ultrasensibles inspirés de la chambre à fils de Georges Charpak.

  1. Multi-purpose extraocular forceps for small-gauge pars plana vitrectomy.

    Science.gov (United States)

    Reichel, Elias; Chun, Dal W; Gurley, Kiersten

    2012-01-01

    A multi-purpose titanium forceps has been developed for small-gauge pars plana vitrectomy surgery. These forceps were designed to provide the vitreoretinal surgeon with a single tool for the extraocular manipulations that are necessary for the placement and removal of 23- and 25-gauge trochars for small-incision, sutureless pars plana vitrectomy surgery. The forceps has been designed to allow for the atraumatic manipulation of the conjunctiva, measurement of distance from the limbus, and a strong purchase of the trochar for both its fixation and removal.

  2. F-actin-like filaments formed by plasmid segregation protein ParM

    DEFF Research Database (Denmark)

    van den Ent, Fusinita; Møller-Jensen, Jakob; Amos, Linda A.;

    2002-01-01

    It was the general belief that DNA partitioning in prokaryotes is independent of a cytoskeletal structure, which in eukaryotic cells is indispensable for DNA segregation. Recently, however, immunofluorescence microscopy revealed highly dynamic, filamentous structures along the longitudinal axis...... of Escherichia coli formed by ParM, a plasmid-encoded protein required for accurate segregation of low-copy-number plasmid R1. We show here that ParM polymerizes into double helical protofilaments with a longitudinal repeat similar to filamentous actin (F-actin) and MreB filaments that maintain the cell shape...

  3. DETECTION ET IDENTIFICATION DES ARYTHMIES CARDIAQUES PAR APPLICATION DES RESEAUX DE NEURONES

    OpenAIRE

    BELGACEM, N.; M.A Chikh; BEREKSI REGUIG, F.

    2003-01-01

    L’électrocardiographie explore l’activité électrique du coeur par enregistrement des variations des ondes électriques de l’activité de polarisation et de dépolarisation ventriculaire et auriculaires du coeur. L’activité cardiaque constitue l’un des plus importants paramètres déterminant l’état d’un sujet. Elle se traduit par l’apparition de plusieurs ondes sur le tracé de l’électrocardiographe : c’est le signal cardiaque, l’électrocardiogramme : ECG. L'analyse du signal ECG et l'i...

  4. Perspectives de développement de la production industrielle d'hydrogène par électrolyse alcaline avancée Development Outlook for Industrial Hydrogen Production by Advanced Alkaline Electrolysis

    Directory of Open Access Journals (Sweden)

    Derive C.

    2006-11-01

    Full Text Available Dans les conditions du développement du programme nucléaire français qui permettent une production d'électricité à un coût intéressant en heures creuses, la production d'hydrogène par électrolyse de l'eau peut être envisagée à moyen terme en compétition avec les autres procédés de fabrication d'hydrogène tels que le reformage de gaz naturel. Dans le cadre de leur coopération, Électricité de France (EDF et le Gaz de France (GDF conduisent, depuis 1976, un programme de recherches et développement sur la production d'hydrogène par électrolyse alcaline de l'eau ayant pour but, par comparaison avec des installations existantes, de réduire le coût d'investissement et de conserver un rendement identique. Les études préalables ont montré que ces objectifs pouvaient être atteints par une électrolyse avancée avec élévation de la densité de courant et de la température. Ces contraintes techniques ont conduit EDF et le GDF à lancer des études sur la tenue chimique et la résistance mécanique des matériaux, sur une sélection de composants de cellules adaptés et sur l'amélioration de la conception d'ensemble des installations. Les deux groupements industriels français - pilotés par Alsthom-Atlantique et Creusot-Loire - associés à ces travaux depuis 1979, ont fixé les conditions de fonctionnement suivantes : - électrolyte à base de potasse (40 % en masse; - température de 120 et 160°C; - pression de 30 et 70 bar. Dans un premier temps, les constructeurs ont réalisé une étude technico-économique sur la production massive d'hydrogène à partir d'usines de puissance d'environ 300 MWe, fourni les plans de détail d'une installation pilote de 2 MWe et entrepris la qualification de leurs choix technologiques sur des boucles-prototypes de 25-30 kWe. Afin de valider plus complètement les choix retenus et d'approfondir les problèmes d'extrapolation à des électrolyseurs de grande taille, les essais sur boucles

  5. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs.

  6. Nanotechnologie : conception à l'échelle atomique par Stéphane Redon. Dynamique moléculaire interactive, entretien avec Serge Crouzy, propos recueillis par Dominique Chouchan.

    OpenAIRE

    Redon, Stéphane; Crouzy, Serge

    2009-01-01

    National audience L'exploration et la manipulation de l'infiniment petit passeront sans doute par la conception assistée par ordinateur : le prototypage virtuel d'objets nanoscopiques concerne un grand nombre d'applications industrielles, pharmacologiques...

  7. Sécurité informatique : peut-on se fier au numérique ? par Hélène Kirchner et Claude Kirchner. Le sens des mots, entretien avec Isabelle de Lamberterie, propos recueillis par Dominique Chouchan.

    OpenAIRE

    Kirchner, Hélène; Kirchner, Claude; Lamberterie, Isabelle de

    2008-01-01

    National audience Dans le monde de l'immatériel, la prévention contre les indésirables passe par des outils logiciels. Leur conception par des méthodes formelles apporte des garanties de plus en plus sérieuses pour anticiper la virtuosité des intrus.

  8. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  9. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  10. Bacterial Mitosis: ParM of Plasmid R1 Moves Plasmid DNA by an Actin-like Insertional Polymerization Mechanism

    DEFF Research Database (Denmark)

    Møller-Jensen, Jakob; Borch, Jonas; Dam, Mette;

    2003-01-01

    Bacterial DNA segregation takes place in an active and ordered fashion. In the case of Escherichia coli plasmid R1, the partitioning system (par) separates paired plasmid copies and moves them to opposite cell poles. Here we address the mechanism by which the three components of the R1 par system...

  11. Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.

    OpenAIRE

    Perichon, B; Tankovic, J; Courvalin, P

    1997-01-01

    We report a mutation in the parE genes of two in vitro mutants of Streptococcus pneumoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyrA leads to higher levels of resistance. This confirms that topoisomerase IV is the primary target of fluoroquinolones in S. pneumoniae.

  12. Improved PET Imaging of uPAR expression using new Cu-64-labeled cross-bridged peptide ligands

    DEFF Research Database (Denmark)

    Persson, Morten; Hosseini, Masood; Madsen, Jacob;

    2013-01-01

    The correlation between uPAR expression, cancer cell invasion and metastases is now well-established and has prompted the development of a number of uPAR PET imaging agents, which could potentially identify cancer patients with invasive and metastatic lesions. In the present study, we synthesized...

  13. Parásitos de animales silvestres en cautiverio en Lima, Perú

    OpenAIRE

    Lily Arrojo

    2013-01-01

    Los parásitos de los animales silvestres en cautiverio peruanos se registran aquí. La mayoría de las especies son nematodos. Dos especies son al patógeno de host: Prosthenorchois elegans y Strongyloides sp.

  14. Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes.

    Science.gov (United States)

    Nikolaou, S; Gasser, R B

    2007-04-01

    Signal transduction molecules play key roles in the regulation of developmental processes, such as morphogenesis, organogenesis and cell differentiation in all organisms. They are organized into 'pathways' that represent a coordinated network of cell-surface receptors and intracellular molecules, being involved in sensing environmental stimuli and transducing signals to regulate or modulate cellular processes, such as gene expression and cytoskeletal dynamics. A particularly important group of molecules implicated in the regulation of the cytoskeleton for the establishment and maintenance of cell polarity is the PAR proteins (derived from partition defective in asymmetric cell division). The present article reviews salient aspects of PAR proteins involved in the early embryonic development and morphogenesis of the free-living nematode Caenorhabditis elegans and some other organisms, with an emphasis on the molecule PAR-1. Recent advances in the knowledge and understanding of PAR-1 homologues from the economically important parasitic nematode, Haemonchus contortus, of small ruminants is summarized and discussed in the context of exploring avenues for future research in this area for parasitic nematodes. PMID:17107637

  15. PAR as a way of organising a social workers labour union in Greenland

    DEFF Research Database (Denmark)

    Andersen, John; Arnfjord, Steven

    Abstract, ALARA2015012:PAR as a way of organising a social workers labour union in Greenland for consideration and inclusion in the programme for the ALARA 9th Action Learning Action Research and 13th Participatory Action Research World Congress to be held at St. George Hotel and Conference Centre...

  16. Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model.

    Science.gov (United States)

    Hao, Wenrui; Friedman, Avner

    2016-01-01

    There are currently over 2.5 million breast cancer survivors in the United States and, according to the American Cancer Society, 10 to 20 percent of these women will develop recurrent breast cancer. Early detection of recurrence can avoid unnecessary radical treatment. However, self-examination or mammography screening may not discover a recurring cancer if the number of surviving cancer cells is small, while biopsy is too invasive and cannot be frequently repeated. It is therefore important to identify non-invasive biomarkers that can detect early recurrence. The present paper develops a mathematical model of cancer recurrence. The model, based on a system of partial differential equations, focuses on tissue biomarkers that include the plasminogen system. Among them, only uPAR is known to have significant correlation to its concentration in serum and could therefore be a good candidate for serum biomarker. The model includes uPAR and other associated cytokines and cells. It is assumed that the residual cancer cells that survived primary cancer therapy are concentrated in the same location within a region with a very small diameter. Model simulations establish a quantitative relation between the diameter of the growing cancer and the total uPAR mass in the cancer. This relation is used to identify uPAR as a potential serum biomarker for breast cancer recurrence.

  17. New Culicoides Latreille of the subgenus Mataemyia Vargas from Pará, Brazil (Diptera: Ceratopogonidae

    Directory of Open Access Journals (Sweden)

    Maria Luiza Felippe-Bauer

    2013-02-01

    Full Text Available Two new species of Culicoides Latreille of the Neotropical subgenus Mataemyia Vargas are described and illustrated based on female specimens from Juruti, Pará, Brazil and compared with their similar congeners. This paper also presents a diagnosis of the subgenus Mataemyia and a systematic key for the identification of the 19 species of the subgenus.

  18. Estructura diferenciable de las clases de equivalencia de un par controlable

    OpenAIRE

    Compta Creus, Albert; Ferrer Llop, Josep; Peña Carrera, Marta

    2007-01-01

    Dado un par de matrices que representa un sistema lineal controlable, estudiamos las clases de equivalencia por la acción individual o combinada de realimentaciones y cambio de variables de estado y de entrada, así como sus intersecciones. En particular, demostramos que son variedades diferenciables y calculamos sus dimensiones.

  19. Leuconychie transversale induite par la manucurie: y a-t-il un apport de la dermoscopie?

    Science.gov (United States)

    Gallouj, Salim; Mernissi, Fatima Zahra

    2014-01-01

    La leuconychie transversale induite par la manucurie est une leuconychie secondaire au microtraumatisme transmis à la matrice unguéale. Nous rapportant une observation où la dermoscopie avait un intérêt considérable pour l'orientation diagnostic. PMID:25368728

  20. Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients

    NARCIS (Netherlands)

    Geboers, Diederik G P J; de Beer, Friso M.; Boer, Anita M Tuip de; van der Poll, Tom; Horn, Janneke; Cremer, Olaf L.; Bonten, Marc J M; Ong, David S Y; Schultz, Marcus J.; Bos, Lieuwe D J

    2015-01-01

    Purpose: We investigated the prognostic value of plasma soluble urokinase plasminogen activator receptor (suPAR) on day 1 in patients with the acute respiratory distress syndrome (ARDS) for intensive care unit (ICU) mortality and compared it with established disease severity scores on day 1. Methods

  1. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    DEFF Research Database (Denmark)

    Bache, Michael; Bosco, Filippo; Brøgger, Anna Line;

    2013-01-01

    the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high...

  2. Apprentissage par renforcement développemental pour la robotique autonome

    OpenAIRE

    Sarzyniec, Luc

    2010-01-01

    La problématique du stage porte sur l'apprentissage par renforcement appliqué à la robotique et plus particulièrement, l'apprentissage d'une tâche complexe divisée en plusieurs tâches plus simples.

  3. uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

    Directory of Open Access Journals (Sweden)

    Mariana Rodrigues Faleiro

    2013-06-01

    Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

  4. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  5. The Utility of Clinicians Ratings of Anxiety Using the Pediatric Anxiety Rating Scale (PARS)

    Science.gov (United States)

    Ginsburg, Golda S.; Keeton, Courtney P.; Drazdowski, Tess K.; Riddle, Mark A.

    2011-01-01

    Clinician ratings of anxiety hold the promise of clarifying discrepancies often found between child and parent reports of anxiety. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered instrument that assesses the frequency, severity, and impairment of common pediatric anxiety disorders and has been used as a primary outcome…

  6. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  7. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, Kathryn A [ORNL

    2009-10-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ({sup 252}Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for {sup 252}Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for {sup 252}Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully

  8. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Andrew J.; Campbell, Robert S.D. [Royal Liverpool and Broadgreen University Teaching Hospitals, Department of Medical Imaging, Liverpool (United Kingdom); Mayor, Peter E. [Leighton Hospital, Department of Medical Imaging, Crewe, Cheshire (United Kingdom); Rees, Dai [Robert Jones and Agnes-Hunt Orthopaedic Hospital, Department of Orthopaedic Surgery, Oswestry, Shropshire (United Kingdom)

    2008-05-15

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  9. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  10. Evaluation of node involvement in non small cell bronchogenic carcinoma. CT-pathology correlation; Valutazione del fattore <> nel carcinoma polmonare non a piccole cellule. Correlazione tra tomografia computerizzata e anatomia patologica

    Energy Technology Data Exchange (ETDEWEB)

    Pirronti, T.; Macis, G.; Sallustio, G.; Minordi, L.M.; Marano, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Radiologia; Granone, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Patologia Chirurgica; Vecchio, F.M. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Anatomia Patologica

    2000-05-01

    metastasis and 2 had lymph nodes either over or less than 1 cm. In all N2 patients the tumor histotype and the mediastinal location were also considered relative to the lesion site. A closer correlation was found with node morphology and density than with size. Indeed, CT sensitivity, specificity and diagnostic accuracy were 97, 100 and 97%, respectively, for the former versus 52, 93 and 77% for the latter. Adeno-carcinoma was the predominant histotype (70.5%) in N2 patients. Metastases to node region 4 were predominant in right upper lobe carcinomas while node region 5 was predominant in left upper lobe lesions. Other criteria can be associated with size to improve CT diagnostic accuracy in N staging. Technique optimization plays a major role particularly in the late, thin slice, examination phase. [Italian] Scopo di questo lavoro e' valutare il ruolo della TC nell'identificazione di altri segni morfologici di interessamento metafisico dei linfonodi con la finalita' di ottenere migliore definizione del fattore N poiche' elemento critico nella stadiazione di un carcinoma polmonare non a piccole cellule e' il fattore N: essendo il diametro l'unico parametro usato per distinguere i linfonodi normali da quelli patologici, la TC del mediastino presenta accuratezza diagnostica solamente dell'80%. Sono stati studiati 137 pazienti con carcinoma polmonare noto o sospetto. Le scansioni TC sono state eseguite con la seguente tecnica: fase angiografica precoce con tecnica spirale e fase tardiva (ritardo 2 minuti, spessore 3 mm, intervallo 5 mm) per l'identificazione delle caratteristiche linfonodali. Nelle scansioni TC cosi' ottenute i linfonodi, localizzati in accordo alla mappa linfonodale secondo l'American Thoracic Society modificata da Mountain e Dresler, sono stati considerati nomrali quando non visibili o, se visibili, con diametro inferiore a un cm e con densita' omogenea; un linfonodo con diametro superiore a un cm con

  11. Caracterização de farinhas de tapioca produzidas no estado do Pará Characterization of tapioca flour obtained in Pará state, Brazil

    Directory of Open Access Journals (Sweden)

    Priscilla Andrade Silva

    2013-01-01

    Full Text Available A farinha de tapioca é um alimento produzido artesanalmente a partir da fécula de mandioca (Manihot esculenta Crantz, amplamente consumida na Região Amazônica. O objetivo deste trabalho foi caracterizar duas farinhas de tapioca produzidas no estado do Pará: uma no Baixo Amazonas e outra na Zona Bragantina. As duas farinhas apresentaram perfis granulométricos distintos e diferença significativa (P 0,05 para a maioria dos parâmetros físico-químicos e tecnológicos analisados. A farinha de tapioca proveniente do Baixo Amazonas apresentou maior umidade (10,7%, em função da maior capacidade de adsorver água, devido a sua maior área específica (menor granulometria. A microscopia óptica com luz polarizada, juntamente com as características dos dois produtos indicou a inexistência de um processo padrão utilizado na produção da farinha de tapioca.Tapioca flour is a typical food produced from cassava starch (Manihot esculenta Crantz, widely consumed in the Amazon Region. The aim of this study was to characterize two tapioca flours produced in Pará State, Brazil one in the West Region and other in Bragantina Area. Both tapioca flour presented distinct particle-size distribution and significant difference (P 0.05 for majority of the physico-chemical and technological parameters. Flour from West Region presented high moisture (10.7%, this due the greater capacity of water adsorption, attributed at its high specific area (smaller particle-size. The optical microscopy with polarized light and the technologic properties of the products did not showed a standard process for the production of tapioca flour.

  12. Perception de l'environnement urbain par les piétons : une exploration par la méthode des focus groups

    OpenAIRE

    GRANIE,MA; MONTEL,MC; Brenac, T.; COQUELET,C; PANNETIER, M; MILLOT, M; Monti, F.

    2011-01-01

    Prendre en compte l'ensemble des usagers de la voirie - et en particulier les usagers des « modes doux » - dans la conception de la voirie et des espaces publics est un enjeu majeur pour les aménageurs. Pourtant, si des connaissances existent concernant l'effet de l'environnement sur l'accidentologie des piétons, très peu de recherches, à l'heure actuelle, ont porté sur la perception de l'environnement des voies (structuration du bâti, de la végétation~) par les piétons, et son influence sur ...

  13. Etude par spectroscopie de Coulomb de points quantiques lateraux individuels et couples

    Science.gov (United States)

    Pioro-Ladriere, Michel

    Des points quantiques contenant un nombre discret et variable d'electrons sont formes dans un gaz bi-dimensionnel d'electrons a l'aide de grilles metalliques. Le transport electrique, le blocage de spin et la detection de charge sont employes comme outils spectroscopiques permettant de sonder les proprietes de ces nanostructures. Ces techniques permettent aussi de controler exactement le nombres d'electrons confines dans des points quantiques individuels et couples en utilisant un patron de grille judicieux. Une technique de refroidissement en tension est developpee afin de minimiser les effets parasites du bruit telegraphique. Ce type de bruit de charge deteriore la stabilite des nanostructures laterales par l'activation d'un minuscule courant de fuite entre les grilles et le gaz bi-dimensionnel. Un modele expliquant le role du refroidissement en tension sur le courant de fuite est presente. L'activation du courant de fuite est confirmee par detection de charge. Les effets des interactions entre les electrons pieges dans un point quantique sont ensuite etudies dans un regime ou il est possible de comparer les resulats experimentaux avec ceux obtenus par diagonalisation exacte. L'etude demontre que la phase associee au facteur de remplissage nu = 2 est instable au-dessus d'un nombre critique d'electrons. Cette instabilite est confirmee experimentalement par blocage de spin. On demontre aussi l'existence d'etats correles dans le regime des renversements de spin, associe au passage de la phase nu = 2 a nu = 1. Les etats correles sont identifies par spectroscopie en transport non lineaire. Cette caracterisation du diagramme de phase de points individuels permet de coupler deux points quantiques configures a nu = 2. Pour ce regime, la nanostructure se comporte comme un systeme a deux niveaux pouvant contenir entre un et quatre electrons de valence et ce, meme si le nombre total d'electrons est plus eleve. Les degres de liberte de charge et de spin des deux points

  14. Impacts of Light Use Efficiency and fPAR Parameterization on Gross Primary Production Modeling

    Science.gov (United States)

    Cheng, Yen-Ben; Zhang, Qingyuan; Lyapustin, Alexei I.; Wang, Yujie; Middleton, Elizabeth M.

    2014-01-01

    This study examines the impact of parameterization of two variables, light use efficiency (LUE) and the fraction of absorbed photosynthetically active radiation (fPAR or fAPAR), on gross primary production(GPP) modeling. Carbon sequestration by terrestrial plants is a key factor to a comprehensive under-standing of the carbon budget at global scale. In this context, accurate measurements and estimates of GPP will allow us to achieve improved carbon monitoring and to quantitatively assess impacts from cli-mate changes and human activities. Spaceborne remote sensing observations can provide a variety of land surface parameterizations for modeling photosynthetic activities at various spatial and temporal scales. This study utilizes a simple GPP model based on LUE concept and different land surface parameterizations to evaluate the model and monitor GPP. Two maize-soybean rotation fields in Nebraska, USA and the Bartlett Experimental Forest in New Hampshire, USA were selected for study. Tower-based eddy-covariance carbon exchange and PAR measurements were collected from the FLUXNET Synthesis Dataset. For the model parameterization, we utilized different values of LUE and the fPAR derived from various algorithms. We adapted the approach and parameters from the MODIS MOD17 Biome Properties Look-Up Table (BPLUT) to derive LUE. We also used a site-specific analytic approach with tower-based Net Ecosystem Exchange (NEE) and PAR to estimate maximum potential LUE (LUEmax) to derive LUE. For the fPAR parameter, the MODIS MOD15A2 fPAR product was used. We also utilized fAPAR chl, a parameter accounting for the fAPAR linked to the chlorophyll-containing canopy fraction. fAPAR chl was obtained by inversion of a radiative transfer model, which used the MODIS-based reflectances in bands 1-7 produced by Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm. fAPAR chl exhibited seasonal dynamics more similar with the flux tower based GPP than MOD15A2 fPAR, especially

  15. Relationship between ParE gene mutation and fluoroquinolones resistance in Mycoplasma hominis%人型支原体ParE基因突变与耐氟喹诺酮类药物的关系

    Institute of Scientific and Technical Information of China (English)

    罗永慧; 段颖卿; 甘雪华; 王旭菲; 舒向荣

    2014-01-01

    目的:探讨人型支原体对氟喹诺酮类药物的耐药机制。方法自临床分离的8株耐氟喹诺酮类药物的人型支原体(Mh),对其ParE基因PCR扩增后进行测序分析,与基因库中的野生型菌株MHPG21基因序列比对,分析ParE基因突变位点与菌株耐氟喹诺酮类药物的关系。结果与野生株MHPG21对比,6株检出ParE基因所编码的氨基酸残基发生D 426→N变异。结论 Mh临床分离株对氟喹诺酮类药物的耐药可能与ParE基因所编码的氨基酸残基D 426→N变异有关。%Objective To explore the fluoroquinolones resistance meachanisms of Mycoplasma hominis (Mh). Methods A total of 8 strains of Mh with different fluoroquinolones resistance phenotype were analyzed, the ParE gene was amplified and sequenced. The sequencing results of ParE gene were compared with that in the wild type strain PG21, then analyzed the relation between ParE gene mutation and fluoroquinolones resistance. Results Compared with wild strain PG21, ParE gene in 6 strains got a D426→N mutation. Conclusion The fluoroquinolones resistance of Mh might be associate with ParE gene D426→N mutation.

  16. Etude et mise au point d'une cellule à électrodes poreuses pour la récupération d'ions métalliques en solution/study of an electrochemical cell with porous electrodes for an environmental application

    OpenAIRE

    Vande Vyver, Olivier

    2008-01-01

    Les procédés électrochimiques présentent beaucoup d’avantages dans le domaine du traitement et de la récupération de matière d’effluents industriels. Cependant, dans le cas de solutions diluées en ions métalliques, les électrodes classiques sont fortement limitées par leur efficacité ainsi que par leur taille. Dès lors, les électrodes poreuses, de par leur surface spécifique importante et de par leur structure particulière qui améliore le transport de matière et donc l’efficacité de l’électro...

  17. Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells

    DEFF Research Database (Denmark)

    Henic, Emir; Noskova, Vera; Høyer-Hansen, Gunilla;

    2009-01-01

    mobilization of uPAR from detergent-resistant domains such as lipid rafts. Estradiol influenced neither the amount of uPAR mRNA nor the rate of uPAR degradation or solubilization. The nuclear ER antagonists ICI 182780 and tamoxifen, which are GPR30 agonists, as well as the specifically constructed GPR30...

  18. Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function

    Science.gov (United States)

    Bucci, M; Vellecco, V; Harrington, L; Brancaleone, V; Roviezzo, F; Mattace Raso, G; Ianaro, A; Lungarella, G; De Palma, R; Meli, R; Cirino, G

    2013-01-01

    Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR2 and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models. Experimental Approach Thoracic aortas were harvested from both naïve and endotoxaemic rats for in vitro studies. Arterial blood pressure was monitored in anaesthetized rats in vivo. LPS was used as a TLR4 agonist while PAR2 activating peptide (AP) was used as a PAR2 agonist. Aortas harvested from TLR4–/– mice were also used to characterize the PAR2 response. Key Results PAR2, but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PAR2AP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR2AP-induced vasorelaxation and PAR2AP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4–/– mice, the expression of PAR2 was reduced and the PAR2AP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective. Conclusions and Implications Cross-talk between PAR2 and TLR4 contributes to vascular homeostasis. PMID:22957757

  19. Stimulation of Naive Monocytes and PBMCs with Coagulation Proteases Results in Thrombin-Mediated and PAR-1-Dependent Cytokine Release and Cell Proliferation in PBMCs Only

    NARCIS (Netherlands)

    Nieuwenhuizen, L.; Falkenburg, W. J. J.; Schutgens, R. E. G.; Roosendaal, G.; van Veghel, K.; Biesma, D. H.; Lafeber, F. P. J. G.

    2013-01-01

    Protease-activated receptors (PARs) are stimulated by proteolytic cleavage of their extracellular domain. Coagulation proteases, such as FVIIa, the binary TF-FVIIa complex, free FXa, the ternary TF-FVIIa-FXa complex and thrombin, are able to stimulate PARs. Whereas the role of PARs on platelets is w

  20. Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.

    Science.gov (United States)

    Wang, Qian; Hurd, Toby W; Margolis, Ben

    2004-07-16

    Tight junctions are the structures in mammalian epithelial cells that separate the apical and basolateral membranes and may also be important in the establishment of cell polarity. Two evolutionarily conserved multiprotein complexes, Crumbs-PALS1 (Stardust)-PATJ and Cdc42-Par6-Par3-atypical protein kinase C, have been implicated in the assembly of tight junctions and in polarization of Drosophila melanogaster epithelia. These two complexes have been linked physically and functionally by an interaction between PALS1 and Par6. Here we identify an evolutionarily conserved region in the amino terminus of PALS1 as the Par6 binding site and identify valine and aspartic acid residues in this region as essential for interacting with the PDZ domain of Par6. We have also characterized, in more detail, the amino terminus of Drosophila Stardust and demonstrate that the interaction mechanism between Stardust and Drosophila Par6 is evolutionarily conserved. Par6 interferes with PATJ in binding PALS1, and these two interactions do not appear to function synergistically. Taken together, these results define the molecular mechanisms linking two conserved polarity complexes.

  1. ParA encoded on chromosome II of Deinococcus radiodurans binds to nucleoid and inhibits cell division in Escherichia coli

    Indian Academy of Sciences (India)

    Vijaya Kumar Charaka; Kruti P Mehta; H S Misra

    2013-09-01

    Bacterial genome segregation and cell division has been studied mostly in bacteria harbouring single circular chromosome and low-copy plasmids. Deinococcus radiodurans, a radiation-resistant bacterium, harbours multipartite genome system. Chromosome I encodes majority of the functions required for normal growth while other replicons encode mostly the proteins involved in secondary functions. Here, we report the characterization of putative P-loop ATPase (ParA2) encoded on chromosome II of D. radiodurans. Recombinant ParA2 was found to be a DNA-binding ATPase. E. coli cells expressing ParA2 showed cell division inhibition and mislocalization of FtsZ-YFP and those expressing ParA2-CFP showed multiple CFP foci formation on the nucleoid. Although, in trans expression of ParA2 failed to complement SlmA loss per se, it could induce unequal cell division in slmAminCDE double mutant. These results suggested that ParA2 is a nucleoid-binding protein, which could inhibits cell division in E. coli by affecting the correct localization of FtsZ and thereby cytokinesis. Helping slmAminCDE mutant to produce minicells, a phenotype associated with mutations in the `Min’ proteins, further indicated the possibility of ParA2 regulating cell division by bringing nucleoid compaction at the vicinity of septum growth.

  2. The Clinical Value of Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels in Autoimmune Connective Tissue Disorders.

    Science.gov (United States)

    Vasarhelyi, Barna; Toldi, Gergely; Balog, Attila

    2016-04-01

    The assessment of the general inflammatory condition of patients with autoimmune connective tissue disorders (ACTD) is a major challenge. The use of traditional inflammatory markers including CRP-levels and erythrocyte sedimentation rate (ESR) is limited by several preanalytical factors and their low specificities. Soluble urokinase plasminogen activator receptor (suPAR) is one of the novel candidate markers that is increasingly used in immune mediated disorders. In our studies we compared suPAR levels of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and ankylosing spondylitis with those of healthy controls. suPAR provided valuable clinical information on disease activity in RA, SLE and SSc. We identified a subgroup of remitted RA patients, who presented still clinical symptoms of inflammatory activity which correlated to high plasma suPAR (while ESR and CRP were normal). In SLE we established specific suPAR cut-off values that support the discrimination between patients with high and those with moderate SLE activity. In patients with SSc suPAR correlated with objective measures of lung and other complications. In the majority of ACTDs including SLE, SSc or RA, suPAR is seemingly a good biomarker that would provide valuable clinical information. However, before the introduction of this novel parameter in laboratory repertoire important issues should be elucidated. These include the establishment of appropriate and disease specific cutoff values, clarification of interfering preanalytical values and underlying conditions and declaration of age- and gender-specific reference ranges. PMID:27683525

  3. Developpement d'algorithmes de reconstruction statistique appliques en tomographie rayons-X assistee par ordinateur

    Science.gov (United States)

    Thibaudeau, Christian

    La tomodensitometrie (TDM) permet d'obtenir, et ce de facon non invasive, une image tridimensionnelle de l'anatomie interne d'un sujet. Elle constitue l'evolution logique de la radiographie et permet l'observation d'un volume sous differents plans (sagittal, coronal, axial ou n'importe quel autre plan). La TDM peut avantageusement completer la tomographie d'emission par positrons (TEP), un outil de predilection utilise en recherche biomedicale et pour le diagnostic du cancer. La TEP fournit une information fonctionnelle, physiologique et metabolique, permettant la localisation et la quantification de radiotraceurs a l'interieur du corps humain. Cette derniere possede une sensibilite inegalee, mais peut neanmoins souffrir d'une faible resolution spatiale et d'un manque de repere anatomique selon le radiotraceur utilise. La combinaison, ou fusion, des images TEP et TDM permet d'obtenir cette localisation anatomique de la distribution du radiotraceur. L'image TDM represente une carte de l'attenuation subie par les rayons-X lors de leur passage a travers les tissus. Elle permet donc aussi d'ameliorer la quantification de l'image TEP en offrant la possibilite de corriger pour l'attenuation. L'image TDM s'obtient par la transformation de profils d'attenuation en une image cartesienne pouvant etre interpretee par l'humain. Si la qualite de cette image est fortement influencee par les performances de l'appareil, elle depend aussi grandement de la capacite de l'algorithme de reconstruction a obtenir une representation fidele du milieu image. Les techniques de reconstruction standards, basees sur la retroprojection filtree (FBP, filtered back-projection), reposent sur un modele mathematiquement parfait de la geometrie d'acquisition. Une alternative a cette methode etalon est appelee reconstruction statistique, ou iterative. Elle permet d'obtenir de meilleurs resultats en presence de bruit ou d'une quantite limitee d'information et peut virtuellement s'adapter a toutes formes

  4. Comparative analysis of a plant pseudoautosomal region (PAR in Silene latifolia with the corresponding S. vulgaris autosome

    Directory of Open Access Journals (Sweden)

    Blavet Nicolas

    2012-06-01

    Full Text Available Abstract Background The sex chromosomes of Silene latifolia are heteromorphic as in mammals, with females being homogametic (XX and males heterogametic (XY. While recombination occurs along the entire X chromosome in females, recombination between the X and Y chromosomes in males is restricted to the pseudoautosomal region (PAR. In the few mammals so far studied, PARs are often characterized by elevated recombination and mutation rates and high GC content compared with the rest of the genome. However, PARs have not been studied in plants until now. In this paper we report the construction of a BAC library for S. latifolia and the first analysis of a > 100 kb fragment of a S. latifolia PAR that we compare to the homologous autosomal region in the closely related gynodioecious species S. vulgaris. Results Six new sex-linked genes were identified in the S. latifolia PAR, together with numerous transposable elements. The same genes were found on the S. vulgaris autosomal segment, with no enlargement of the predicted coding sequences in S. latifolia. Intergenic regions were on average 1.6 times longer in S. latifolia than in S. vulgaris, mainly as a consequence of the insertion of transposable elements. The GC content did not differ significantly between the PAR region in S. latifolia and the corresponding autosomal region in S. vulgaris. Conclusions Our results demonstrate the usefulness of the BAC library developed here for the analysis of plant sex chromosomes and indicate that the PAR in the evolutionarily young S. latifolia sex chromosomes has diverged from the corresponding autosomal region in the gynodioecious S. vulgaris mainly with respect to the insertion of transposable elements. Gene order between the PAR and autosomal region investigated is conserved, and the PAR does not have the high GC content observed in evolutionarily much older mammalian sex chromosomes.

  5. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.

    Science.gov (United States)

    Zhao, Baoyu; Gandhi, Sonu; Yuan, Cai; Luo, Zhipu; Li, Rui; Gårdsvoll, Henrik; de Lorenzi, Valentina; Sidenius, Nicolai; Huang, Mingdong; Ploug, Michael

    2015-03-27

    The urokinase-type plasminogen activator receptor (uPAR) is a multidomain glycolipid-anchored membrane protein, which facilitates extracellular matrix remodeling by focalizing plasminogen activation to cell surfaces via its high-affinity interaction with uPA. The modular assembly of its three LU (Ly6/uPAR-like) domains is inherently flexible and binding of uPA drives uPAR into its closed conformation, which presents the higher-affinity state for vitronectin thus providing an allosteric regulatory mechanism. Using a new class of epitope-mapped anti-uPAR monoclonal antibodies (mAbs), we now demonstrate that the reciprocal stabilization is indeed also possible. By surface plasmon resonance studies, we show that these mAbs and vitronectin have overlapping binding sites on uPAR and that they share Arg91 as hotspot residue in their binding interfaces. The crystal structure solved for one of these uPAR·mAb complexes at 3.0Å clearly shows that this mAb preselects the closed uPAR conformation with an empty but correctly assembled large hydrophobic binding cavity for uPA. Accordingly, these mAbs inhibit the uPAR-dependent lamellipodia formation and migration on vitronectin-coated matrices irrespective of the conformational status of uPAR and its occupancy with uPA. This is the first study to the best of our knowledge, showing that the dynamic assembly of the three LU domains in uPARwt can be driven toward the closed form by an external ligand, which is not engaging the hydrophobic uPA binding cavity. As this binding interface is also exploited by the somatomedin B domain of vitronectin, therefore, this relationship should be taken into consideration when exploring uPAR-dependent cell adhesion and migration in vitronectin-rich environments. PMID:25659907

  6. Linear study and bundle adjustment data fusion; Application to vision localization; Recherche lineaire et fusion de donnees par ajustement de faisceaux; Application a la localisation par vision

    Energy Technology Data Exchange (ETDEWEB)

    Michot, J.

    2010-12-09

    integrate this additional information directly into an extended bundle adjustment, by adding a constraint term in the weighted cost function. We evaluate three methods (based on machine learning or regularization) that dynamically select the weight associated to the constraint and show that these methods can be used in a real time multi-sensor SLAM, and validate them with different types of constraint on the orientation or on the scale. Experiments conducted on real video sequences show that this technique of constrained bundle adjustment reduces the drifts observed with the classical vision algorithms and improves the global accuracy of the positioning system. (author) [French] Les travaux presentes dans ce manuscrit concernent le domaine de la localisation et la reconstruction 3D par vision artificielle. Dans ce contexte, la trajectoire d'une camera et la structure 3D de la scene filmee sont initialement estimees par des algorithmes lineaires puis optimisees par un algorithme non-lineaire, l'ajustement de faisceaux. Cette these presente tout d'abord une technique de recherche de l'amplitude de deplacement (recherche lineaire), ou line search pour les algorithmes de minimisation iterative. La technique proposee est non iterative et peut etre rapidement implantee dans un ajustement de faisceaux traditionnel. Cette technique appelee recherche lineaire algebrique globale (G-ALS), ainsi que sa variante a deux dimensions (Two way-ALS), accelerent la convergence de l'algorithme d'ajustement de faisceaux. L'approximation de l'erreur de reprojection par une distance algebrique rend possible le calcul analytique d'une amplitude de deplacement efficace (ou de deux pour la variante Two way-ALS), par la resolution d'un polynome de degre 3 (G-ALS) ou 5 (Two way-ALS). Nos experimentations sur des donnees simulees et reelles montrent que cette amplitude, optimale en distance algebrique, est performante en distance euclidienne, et permet

  7. Etude numérique de la condensation en film par convection mixte dans un canal vertical

    OpenAIRE

    Merouani, Lazhar; Zeghmati, Belkacem; Chesneau, Xavier; Belhamri, Azedine

    2007-01-01

    International audience Une étude numérique de la condensation par convection mixte laminaire d'air humide dans un canal vertical à parois non isothermes est présentée. Les transferts dans la phase liquide et dans l'air sont décrits par les équations de conservation de masse, de quantité de mouvement, d'énergie et de diffusion. Le couplage entre les équations des deux phases est assuré par la continuité des contraintes de cisaillement, des densités de flux thermique et massique à l'interfac...

  8. Cardiovascular risk prediction in the general population with use of suPAR, CRP, and Framingham Risk Score

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Marott, Jacob L; Sehestedt, Thomas;

    2013-01-01

    BACKGROUND: The inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR) and C-reactive protein (CRP) independently predict cardiovascular disease (CVD). The prognostic implications of suPAR and CRP combined with Framingham Risk Score (FRS) have not been determined. METHODS......: From 1993 to 1994, baseline levels of suPAR and CRP were obtained from 2315 generally healthy Danish individuals (mean [SD] age: 53.9 [10.6] years) who were followed for the composite outcome of ischemic heart disease, stroke and CVD mortality. RESULTS: During a median follow-up of 12.7years, 302...

  9. Utility of the plasma level of suPAR in monitoring risk of mortality during TB treatment

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian;

    2012-01-01

    Objective: To investigate whether changes in the plasma level of soluble urokinase plasminogen activator receptor (suPAR) can be used to monitor tuberculosis (TB) treatment efficacy. Design: This prospective cohort study included 278 patients diagnosed with active pulmonary TB and followed...... that elevated suPAR level at time of initiation of TB treatment is associated with increased risk of mortality. Furthermore, increased suPAR levels after one month of treatment was associated with increased risk of mortality during the remaining 7-month treatment period....

  10. Cathepsin B and uPAR Knockdown Inhibits Tumor-induced Angiogenesis by Modulating VEGF Expression in Glioma

    OpenAIRE

    MALLA, RAMA RAO; Gopinath, Sreelatha; Christopher S Gondi; Alapati, Kiranmai; Dinh, Dzung H.; Gujrati, Meena; Rao, Jasti S.

    2011-01-01

    Angiogenesis, which is the process of sprouting of new blood vessels from pre-existing vessels, is vital for tumor progression. Proteolytic remodeling of extracellular matrix is a key event in vessel sprouting during angiogenesis. Urokinase plasminogen activator receptor (uPAR) and cathepsin B are both known to be overexpressed and implicated in tumor angiogenesis. In the present study, we observed that knockdown of uPAR and cathepsin B using puPAR (pU), pCathepsin B (pC), and a bicistronic c...

  11. Sécurité et immigration : vers une gouvernementalité par l'inquiétude ?

    OpenAIRE

    Bigo, Didier

    1998-01-01

    L'immigration est lue à travers le prisme de la sécurité par certains hommes politiques, par les polices et certains services sociaux, par nombre de journalistes et une fraction de l'opinion publique. Malgré les critiques fréquentes et argumentées d'une telle perception, malgré l'existence de discours alternatifs, cette lecture continue, très largement, d'être dominante. Pourquoi ? Qu'est ce qui pousse tous ces acteurs à faire un lien entre crime, chômage, terrorisme, fanatisme et migration ?...

  12. Estuarine morphometry governs optically active substances, Kd(PAR) and beam attenuation

    DEFF Research Database (Denmark)

    Lund-Hansen, L. C.; Nielsen, J. M.; Blüthgen, J.;

    2013-01-01

    this spatial distribution. Partition and multiple regression analyses showed that Chl-a governed Kd(PAR) and beam attenuation coefficient in both estuaries. Significant, high correlations were obtained by multiple regression analyses in the estimation of Kd(PAR) and beam attenuation coefficients in the two......Data on optical properties such as diffuse attenuation coefficient Kd(PAR), beam attenuation coefficient (cp) and the optically active constituents (OACs) CDOM, Chl-a and suspended particulate matter were obtained in a Danish temperate coastal plain estuary (56°N) and a Vietnamese tropical ria (12...

  13. Citotossicity in immune system's cells exposed in vitro to a microwave electromagnetic field in two different exposure systems operating at mobile telephones frequencies; Citotossicita' in cellule del sistema immunitario esposte in vitro al campo elettromagnetico a microonde in due diversi sistemi espositivi operanti alle frequenze della telefonia mobile

    Energy Technology Data Exchange (ETDEWEB)

    Scarcella, E.; Ardoino, L.; Galloni, P.; Mancini, S.; Marino, C. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    funzionamento di cellule macrofagiche stabilizzate e coltivate in vitro (RAW 264.7) responsabili dei meccanismi di difesa specifica e aspecifica del sistema immunitario. Sono stati, inoltre, standardizzati due diversi sistemi espositivi operanti a 900 MHz a differenti livelli di densita' di potenza (da 1 a 100 W/m{sup 2}) per garantire condizioni elettromagnetiche omogenee, idonee condizioni di incubazione delle cellule e la riproducibilita' degli esperimenti. Il lavoro di standardizzazione dei sistemi espositivi e i risultati sperimentali di questa ricerca, che hanno evidenziato differenze significative della crescita e della funzionalita' macrofagica solo al livello di densita' di potenza piu' elevato (100 W/m{sup 2}), ma recuperare dopo 48 ore dall'esposizione, risultano essere preliminari e propedeutici per una programmazione sperimentale futura atta ad approfondire una valutazione bio-tossicologica in vitro.

  14. La critique de l’esse intentionale par Guillaume d’Ockham

    OpenAIRE

    Celeyrette, Jean

    2014-01-01

    Brentano dans son introduction des objets in-existants affirme qu’il s’est inspiré de thèses médiévaleset on considère généralement qu’il se réfère aux thèses scotistes. En fait l’intentio a été l’objet d’intenses débats du milieu du XIIIe au milieu du XIVe siècle. On se propose ici d’en donner une idée à partir de la critique la plus radicale de la notion d’esse intentionale par Guillaume d’Ockham. Pour cela on commence par rappeler les principales thèses qui font intervenir des intentiones ...

  15. Réalisation par coulage en barbotine de revêtements anti-usure

    OpenAIRE

    Sonney, Vincent; Bidaux, Jacques-Eric; Carreño-Morelli, Efraín

    2009-01-01

    Objectifs : Réalisation d’un revêtement anti-usure. Il s’agira dans un premier temps, de développer par technologie des poudres un alliage superélastique en CuAlNi. Les propriétés tribologiques sont en outre mesurées et la possibilité d’y ajouter des renforts céramiques est abordée. Dans un deuxième temps, la mise en forme par élaboration d’une barbotine à base de cuivre est étudiée. Deux utilisations de cette barbotine sont exécutées : le coulage en bande et le trempage. Résultats : Plusieur...

  16. Couplage thermomécanique lors de la soudure par ultrasons : application pour les thermoplastiques

    OpenAIRE

    Ha Minh, Duc

    2009-01-01

    Cette thèse présente un couplage thermodynamique pour une modélisation approfondie du processus de soudure par ultrasons, surtout la soudure des thermoplastiques. Il s'agit de bien connaître le mode de fonctionnement des ensembles acoustiques réalisant la soudure ainsi que le comportement des matériaux à souder. En conséquence, les propriétés de ces matériaux, surtout celles nécessaires pour la modélisation par éléments finis, sont identifiées. Les paramètres mécaniques et thermiques sont mes...

  17. Rabies in humans and non-human in the state of Pará, Brazilian Amazon.

    Science.gov (United States)

    Fernandes, Marcus Emanuel Barroncas; Costa, Lanna Jamile Corrêa da; Andrade, Fernanda Atanaena Gonçalves de; Silva, Lucila Pereira

    2013-01-01

    We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p<0.01), but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará, where rabies cases are proportionally five times greater than other mesoregions, suggesting that increased livestock production may influence the increase of this zoonosis. PMID:23477765

  18. Rabies in humans and non-human in the state of Pará, Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Marcus Emanuel Barroncas Fernandes

    2013-04-01

    Full Text Available We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p < 0.01, but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará, where rabies cases are proportionally five times greater than other mesoregions, suggesting that increased livestock production may influence the increase of this zoonosis.

  19. SURGICALLY INDUCED ASTIGMATISM AFTER 20G VS 23G PARS PLANA VITRECTOMY

    Directory of Open Access Journals (Sweden)

    Lokabhi Reddy

    2015-05-01

    Full Text Available Pars Plana Vitrectomy is done to clear the Vitreous cavity of the Eye. Trans conjunctival Sutureless Vitrectomy with 23G & 25G has become more popular over the Conventional 20G Vitrectomy in recent times. It has many advantages. Less amount of Surgically Induc ed Astigmatism is one of the Advantages with Sutureless Vitrectomy, which will have the Advantage of Early Visual rehabilitation with better Vision. An interventional comparative study was done between 20G & 23 G Pars Plana Vitrectomy in 2 Groups of 30 pat ients each to assess the amount of Post - Operative Astigmatism. The cases were followed up for 6 months to assess the long term effects. There was a significant difference in immediate Post - Operative Astigmatism. But after some time the difference is much l ess showing that the main advantage on Astigmatism with Trans conjunctival Sutureless Vitrectomy is noted mainly during the first few weeks after the Surgery.

  20. Classe inversée et apprentissage par les pairs dans le supérieur

    OpenAIRE

    THIERRY, SPRIET; Mourey, Bénédicte

    2015-01-01

    International audience Nous présentons ici les réflexions en amont et en aval à l'expérimentation pédagogique que nous avons conduit cette année sur un cours de modélisation de bases de données en deuxième année de licence informatique. La mise en pratique d'une pédagogie active s'est faite au travers des principes de classe inversée et d'apprentissage par les pairs. La présentation met en évidence les gains obtenus par ces changements pédagogiques et souligne les points pratiques auxquels...

  1. Estado nutricional en niños con parálisis cerebral infantil

    Directory of Open Access Journals (Sweden)

    Drianet Castillo Peña

    2014-08-01

    Full Text Available Se realizó un estudio descriptivo, con el objetivo de caracterizar el estado nutricional de los niños que ingresaron en el Hospital Pediátrico Provincial “Mártires de las Tunas”con parálisis cerebral, en el periodo comprendido de enero a diciembre de 2012. La muestra estuvo integrada por 25 niños. La evaluación nutricional se hizo según las tablas cubanas. Se observó que predominó el sexo masculino, siendo más afectado el grupo de mayores de siete años, prevaleció la desnutrición en niños con parálisis cerebral severa. Los déficits nutricionales más frecuentes fueron la anemia, seguido de la hipoalbuminemia

  2. Hydrodiffusion assistée par micro-ondes : nouvelle technique d'éco-extraction

    OpenAIRE

    Zill-E-Huma, Huma

    2010-01-01

    L'hydrodiffusion générée par micro-ondes est une nouvelle technique d'extraction mise au point au sein de l'Université d'Avignon et des Pays de Vaucluse. Ce procédé est une combinaison entre une technique traditionnelle et une technologie innovante. En effet, le chauffage par micro-ondes a permis d'initier et de générer le transfert de matière et de chaleur de l"intérieur des matrices végétales (oignons) vers l'extérieur et de réduire de façon considérable les temps d'extraction des antioxyda...

  3. El lenguaje no vocálico en la parálisis cerebral infantil

    OpenAIRE

    Frutos García, Elísabet

    2014-01-01

    Este Trabajo de Fin de Grado pretende abordar la comunicación y el lenguaje en un caso concreto de Parálisis Cerebral Infantil. En primer lugar, se propondrá una fundamentación teórica en la que será posible apreciar las características generales de esta discapacidad; para establecer una relación con la comunicación y el lenguaje que presentan estas personas. A partir de este estudio sobre la Parálisis Cerebral Infantil y a modo de cierre, se diseña un programa de intervención en el que s...

  4. Proyecto didáctico para alumnos con parálisis cerebral

    OpenAIRE

    Pozas León, Jessica

    2015-01-01

    En el presente Trabajo de Fin de Grado, se diseña un proyecto didáctico como medio de intervención educativa, teniendo como fin realizar actividades para trabajar con alumnos con Parálisis Cerebral, en el primer ciclo de Educación Primaria, realizando las adaptaciones más adecuadas. Se sitúa el tema empezando con una fundamentación teórica sobre el origen de la parálisis cerebral, sus características y proyectos que existen para abordar esta cuestión en educación, así como las adaptaciones...

  5. [Slaves in purgatory: the Tucunduba Leprosarium (Pará, nineteenth century)].

    Science.gov (United States)

    Henrique, Márcio Couto

    2012-12-01

    The article analyzes the experience of the slaves interned at the Tucunduba Leprosarium in Belém, state of Pará during the nineteenth century. The slaves were freed once they showed the marks of their leprosy, and expectations were that they would submit to the segregation policy meant to keep them from contact with the rest of the population. The documentation produced by Santa Casa de Misericórdia hospital in Pará and by the province's political authorities reveals the strategies the slaves devised in response to this policy; they used their numerical predominance at the leprosarium to create a network of solidarity that allowed them to recreate their lives and stand in opposition to the type of nation that the era's hygienist theories envisioned.

  6. Archéologie, patrimoine culturel et datation par le carbone 14

    OpenAIRE

    Daugas, Jean-Pierre

    2014-01-01

    On rappellera que les intervenants étaient conviés à démontrer la nécessité d’une nouvelle chaîne de datation par smadédiée à l’archéologie et à l’histoire de l’art ainsi qu’à illustrer l’exigence méthodologique et la rigueur scientifique à même de fonder ce programme. La difficulté à séparer la matière des communications individuelles et des débats développés par chaque table ronde, la richesse même des discussions conduites, incitent à présenter ici l’ensemble des points forts abordés dans ...

  7. Manipulation quantique de la lumière par un amplificateur non linéaire

    Science.gov (United States)

    Symul, T.; Bencheikh, K.; Levenson, J. A.

    2002-06-01

    Nous proposons un dispositif original, appelé Amplificateur Non Linéaire (ANL), permettant la génération et la manipulation d'états quantiques de la lumière. Ce dispositif permet une compression du bruit quantique de la lumière en dessous de la limite quantique standard plus efficace que celle obtenue par interactions non linéaires du second ordre ou du troisième ordre. Il permet également d'inverser les fluctuations quantiques en intensité de la lumière, et de produire des photons jumeaux ayant des corrélations quantiques plus élevées et plus robustes que ceux produits par un amplificateur paramétrique seul.

  8. Minimally Invasive Direct Repair of Bilateral Lumbar Spine Pars Defects in Athletes

    Directory of Open Access Journals (Sweden)

    Gabriel A. Widi

    2013-01-01

    Full Text Available Spondylolysis of the lumbar spine has traditionally been treated using a variety of techniques ranging from conservative care to fusion. Direct repair of the defect may be utilized in young adult patients without significant disc degeneration and lumbar instability. We used minimally invasive techniques to place pars interarticularis screws with the use of an intraoperative CT scanner in three young adults, including two athletes. This technique is a modification of the original procedure in 1970 by Buck, and it offers the advantage of minimal muscle dissection and optimal screw trajectory. There were no intra- or postoperative complications. The detailed operative procedure and the postoperative course along with a brief review of pars interarticularis defect treatment are discussed.

  9. « Emportés par le mix »

    OpenAIRE

    Jouvenet, Morgan

    2007-01-01

    Figure centrale de l’univers des musiques électroniques, le dj est responsable du scénario indissociablement émotionnel et musical qui rassemble les auditeurs sur les pistes de danse. Les choix qui décident de la forme de son « mix » entraînent à examiner les règles et les modèles véhiculés par ce « monde de l’art » en formation, dans lequel la paternité des performances musicales se distribue de manière frappante, suivant un ensemble d’hypothèses communes sur la musique et ses effets. Le par...

  10. Disrupting the right pars opercularis with electrical stimulation frees the song: case report.

    Science.gov (United States)

    Herbet, Guillaume; Lafargue, Gilles; Almairac, Fabien; Moritz-Gasser, Sylvie; Bonnetblanc, François; Duffau, Hugues

    2015-12-01

    The authors report the first case of a strikingly unusual speech impairment evoked by intraoperative electrostimulation in a 36-year-old right-handed patient, a well-trained singer, who underwent awake surgery for a right fronto-temporo-insular low-grade glioma. Functionally disrupting the pars opercularis of the right inferior frontal gyrus led the patient to automatically switch from a speaking to a singing mode of language production. Given the central role of the right pars opercularis in the inhibitory control network, the authors propose that this finding may be interpreted as possible evidence for a competitive and independent neurocognitive subnetwork devoted to the melodically intoned articulation of words (normal language-based vs singing-based) in subjects with high expertise. From a more clinical perspective, such data may have implications for awake neurosurgery, especially to preserve the quality of life for singers.

  11. L'arbitrage et l'exportation de devises par valise

    OpenAIRE

    González, Jorge Iván; Pecha, Arcenio; Puentes, Julio

    2011-01-01

    L'article examine la signification et les implications de l'exportation de devises par valise depuis la perspective de l'arbitrage. Tout d'abord la signification économique de l'arbitrage y est abordée et il y est montré que l'exportation de devises par valise est une forme d'arbitrage. Le mouvement physique de devises a un sens économique parce que les différences entre le dollar de la rue et le taux représentatif du marché sont très importantes. Ce rapprochement met en cause d'autres lectur...

  12. Magnétométrie à hélium par pompage laser: le bilan

    Science.gov (United States)

    Gilles, H.; Hamel, J.; Monfort, Y.

    2002-06-01

    Depuis 1986, l'équipe Physique Atomique et Capteurs du CIRIL-ISMRA de Caen étudie les magnétomètres à hélium par pompage laser. On présente ici le bilan de ces travaux de recherche et les performances des deux prototypes (hélium4 et hélium3) réalisés au Laboratoire.

  13. Armadillo : tranchée creusée par l'arroyo Campanero

    OpenAIRE

    Michelet, Dominique

    1981-01-01

    Près d'Armadillo, municipio Armadillo, San Luis Potosi.Depuis la "piste" ouverte récemment (sur l'initiative du curé d'Armadillo) et qui relie Armadillo : San Nicolas Tolentino, vue générale en direction de l'Ouest. Au premier plan, on aperçoit la tranchée creusée par l'arroyo Campanero

  14. A comparison study of corneal topographic changes following 20-, 23-, and 25-G pars plana vitrectomy

    OpenAIRE

    Alexandre Achille Grandinetti; Vinicius Kniggendorf; Luciane Bugmann Moreira; Carlos Augusto Moreira Junior; Ana Tereza Ramos Moreira

    2015-01-01

    ABSTRACTPurpose:To evaluate and compare corneal topographic changes following pars plana vitrectomy with the 23-gauge (G) and 25-G transconjuntival sutureless vitrectomy system as well as the standard 20-G vitrectomy system.Methods:We prospectively evaluated corneal topographic changes in 45 eyes of 45 patients divided into three groups according to vitrectomy system used (20-, 23-, and 25-G). All patients underwent computer-assisted videokeratography using an EyeSys System 3000 topographer p...

  15. Surgical results of combined pars plana vitrectomy and phacoemulsification for vitreous hemorrhage in PDR

    OpenAIRE

    Canan H; Sizmaz S; Altan-Yaycioğlu R

    2013-01-01

    Handan Canan,1 Selçuk Sizmaz,2 Rana Altan-Yaycioğlu1 1Department of Ophthalmology, Adana Teaching and Medical Research Center, Baskent University School of Medicine, 2Department of Ophthalmology, Cukurova University School of Medicine, Yuregir, Adana, Turkey Background: The purpose of this study was to evaluate the effectiveness, safety, and incidence of complications after combined clear corneal phacoemulsification with intraocular lens implantation and pars plana vitrectomy in ...

  16. Acceptabilite et faisabilite de la psychotherapie par les patients avec trouble de personnalite limite

    OpenAIRE

    Cailhol, L.; Bouchard, S.; Belkadi, A.; Benkirane, G.; Corduan, G.; Dupouy, S.; Villeneuve, E.; Guelfi, J.-D.

    2010-01-01

    Resume Le trouble de personnalite limite est un trouble grave associe a de serieuses limitations psychosociales. La prevalence de ce trouble est de 1,8 %. Les perspectives de sante publique convergent avec les observations cliniques pour questionner leurs trajectoires de soin. En effet, les psychotherapies sont peu mises en ?uvre pour des raisons de moyens et d?acceptabilite par les sujets eux-memes. A travers une revue de litterature, nous presentons des donnees sur l?accessibilit...

  17. Pars plana vitrectomy for malignant glaucoma in nonglaucomatous and in filtered glaucomatous eyes

    Directory of Open Access Journals (Sweden)

    Matlach J

    2012-11-01

    Full Text Available Juliane Matlach, Joerg Slobodda, Franz Grehn, Thomas KlinkDepartment of Ophthalmology, University of Wuerzburg, Wuerzburg, GermanyPurpose: To assess the outcomes of pars plana vitrectomy for the treatment of malignant glaucoma in patients with and without previous filtration surgery.Patients and methods: Data of 15 patients developing malignant glaucoma after trabeculectomy (60% or following ophthalmic interventions other than filtration surgery (40% were recorded retrospectively. Pars plana vitrectomy was performed in case of failed medical or laser treatment recreating the normal pathway of aqueous humor. The main outcome measures were the postoperative intraocular pressure (IOP, the frequency of complications, and success rate based on the following criteria: IOP reduction by ≥20% and to ≤21 mmHg (definition one or an IOP < 18 mmHg (definition two with (qualified success and without (complete success glaucoma medication.Results: Vitrectomy reduced IOP from baseline in eyes with and without previous trabeculectomy during a median follow-up of 16.4 months (range 7 days to 58 months; although the majority of patients required glaucoma medication to reach desired IOP. The complete success rates were 11% (both definitions for patients with filtering blebs and none of the patients without previous trabeculectomy had complete success at the 12-month visit. Complications were few and included transient shallowing of the anterior chamber, choroidal detachment, corneal decompensation, filtering bleb failure, and need for further IOP-lowering procedures.Conclusion: Pars plana vitrectomy is equally effective for malignant glaucoma caused by trabeculectomy or interventions other than filtration surgery, although IOP-lowering medication is necessary in nearly all cases to maintain target IOP.Keywords: ciliolenticular block glaucoma, malignant glaucoma, pars plana vitrectomy, trabeculectomy

  18. Le contrat de soutien et d'aide par le travail

    OpenAIRE

    Poinsot, Olivier

    2012-01-01

    Nouvel outil contractuel du droit des institutions sociales et médico-sociales, le contrat de soutien et d'aide par le travail exprime les mutations des politiques publiques en matière d'action sociale. Mais son régime contribue également à l'émergence d'une théorie plus globale du contrat de séjour.

  19. Ensayo. Parálisis cerebral infantil. Estado actual y posibilidades futuras de tratamiento

    OpenAIRE

    Hernando Rafael; Victor Ayulo

    1991-01-01

    El trasplante tejido nervioso embrionario y fetal en diferentesportes l encéfalo a nivel experimental, abre nuevas posibilidades futuras su utilizacidn en humanos. La aplicación clínica reciente en el tratamiento la esquiwfrenia y enfermedad Parkinson es apenas el comienw del largo camino reconstrucci6n cerebral. Los autores creen que esta técnica puede utilizarse también en el tratamiento la parálisis cerebral infantil.

  20. Alterations of palm oil (Elaeis guineensis) in the continuous industrial par frying of breaded chicken snacks

    OpenAIRE

    Débora Rezende Ferreira; Adelaide Del Pino Beléia; Rui Sérgio dos Santos Ferreira da Silva

    2014-01-01

    The physical and chemical alterations in palm oil during continuous industrial par frying of breaded chicken snacks were evaluated using a pseudo first-order kinetic model. The acidity index, refractive index, concentration of polar compounds, viscosity, color, and absorbance (232 and 268 nm) of 238 samples of the frying oil collected during 26 days of production were analyzed. For all of the analyses, the results of the oil were below the limits recommended for oil disposal, indicating that ...

  1. Snake assemblages of Marajó Island, Pará state, Brazil

    OpenAIRE

    Gerson Moreira Rodrigues; Gleomar Fabiano Maschio; Ana Lúcia da Costa Prudente

    2016-01-01

    ABSTRACT We describe the diversity, natural history and structure of snake assemblages from Marajó Island, state of Pará, Brazil, after analyzing 439 specimens deposited in herpetological collections. We tested the hypothesis that snake assemblages from forest and open areas of Marajó Island are distinct with regard to their structure, composition and functional groups. To compare the snake composition of the forest and open areas of Marajó with other comparable assemblages in Brazil, Princip...

  2. The Rules of Hearing Conservation Program and One Sample Study in Pars- Minoo Company

    OpenAIRE

    Ahmad Keshani; Saeed Farahani

    1996-01-01

    Hearing conservation is one of the useful programs in industrial audiology. Few studies have been reported on this issue. Performing this program is always accompanied with some problems, In a way that lacking enough attention can cause deviation from the main instructions in the program. In the current study we will first of all, have a look on the academic foundations of a hearing conservation program and then will discuss performing such a program in Pars- Minoo Company which have been pe...

  3. CALiPER Application Summary Report 20. LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-11-01

    This report analyzes the independently tested photometric performance of 38 LED PAR38 lamps. The test results indicate substantial improvement versus earlier CALiPER testing of similar products, and performance comparable to recent data from LED Lighting Facts and ENERGY STAR. Additional testing that focuses on performance attributes beyond those covered by LM-79-08 is planned for this group of lamps, and will be presented in subsequent reports.

  4. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1 in breast cancer invasion: signaling partners, hierarchy and physiological significance.

    Directory of Open Access Journals (Sweden)

    Irit Cohen

    Full Text Available BACKGROUND: While protease-activated-receptor 1 (PAR(1 plays a central role in tumor progression, little is known about the cell signaling involved. METHODOLOGY/PRINCIPAL FINDINGS: We show here the impact of PAR(1 cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis model in vivo, with biochemical analyses in vitro. Large and highly vascularized tumors were generated by cells over-expressing wt hPar1, Y397Z hPar1, with persistent signaling, or Y381A hPar1 mutant constructs. In contrast, cells over-expressing the truncated form of hPar1, which lacks the cytoplasmic tail, developed small or no tumors, similar to cells expressing empty vector or control untreated cells. Antibody array membranes revealed essential hPar1 partners including Etk/Bmx and Shc. PAR(1 activation induces Etk/Bmx and Shc binding to the receptor C-tail to form a complex. Y/A mutations in the PAR(1 C-tail did not prevent Shc-PAR(1 association, but enhanced the number of liver metastases compared with the already increased metastases obtained with wt hPar1. We found that Etk/Bmx first binds via the PH domain to a region of seven residues, located between C378-S384 in PAR(1 C-tail, enabling subsequent Shc association. Importantly, expression of the hPar1-7A mutant form (substituted A, residues 378-384, which is incapable of binding Etk/Bmx, resulted in inhibition of invasion through Matrigel-coated membranes. Similarly, knocking down Etk/Bmx inhibited PAR(1-induced MDA-MB-435 cell migration. In addition, intact spheroid morphogenesis of MCF10A cells is markedly disrupted by the ectopic expression of wt hPar1. In contrast, the forced expression of the hPar1-7A mutant results in normal ball-shaped spheroids. Thus, by preventing binding of Etk/Bmx to PAR(1 -C-tail, hPar1 oncogenic properties are abrogated. CONCLUSIONS/SIGNIFICANCE: This is the first demonstration that a cytoplasmic portion of the PAR(1 C-tail functions as a scaffold

  5. Soluble urokinase plasminogen activator receptor (suPAR) in acute care

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck;

    2016-01-01

    . METHODS: This registry-based retrospective cohort study included 4343 consecutively admitted patients from the Acute Medical Unit at a large Danish university hospital. Time to readmission and death were analysed by multiple Cox regression. Results were reported as HRs for 30-day and 90-day follow......OBJECTIVE: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker associated with presence and progression of disease and with increased risk of mortality. We aimed to evaluate the unspecific biomarker suPAR as a prognostic marker in patients admitted to acute care......-up. RESULTS: During 30-day follow-up, 782 patients (18.0%) were readmitted and 224 patients (5.2%) died. Comparing 30-day readmission and mortality between patients in the highest and lowest suPAR quartiles yielded HRs of 2.11 (95% CI 1.70 to 2.62) and 4.11 (95% CI 2.46 to 6.85), respectively, when adjusting...

  6. Equine pituitary pars intermedia dysfunction: current perspectives on diagnosis and management

    Directory of Open Access Journals (Sweden)

    Spelta CW

    2015-08-01

    Full Text Available Caroline W Spelta Townsville Vet Clinic, Townsville, QLD, Australia Abstract: Equine pituitary pars intermedia dysfunction (PPID is a neurodegenerative disease of the hypothalamus, resulting in the loss of dopaminergic inhibition of pars intermedia. An oxidative stress injury of unknown etiology has been suggested to initiate the neurodegeneration. While hypertrichosis (formerly known as hirsutism is considered pathognomic for advanced disease, the antemortem diagnosis of subclinical and early disease has continued to prove difficult. Numerous tests have been used with varying sensitivities and specificities. The overnight dexamethasone suppression test, originally documented to have 100% sensitivity and specificity in horses with advanced disease, has proven to be less valuable in identifying early disease. Basal plasma adrenocorticotropin concentrations have improved sensitivity and specificity when sampled during the autumn months, and α-melanocyte-stimulating hormone, while not yet commercially available, shows promise as a sensitive and specific single sample test. Recent advances in our knowledge include the strong association between laminitis and hyperinsulinemia, both common clinical signs associated with PPID. The pathogenesis of hyperinsulinemia, laminitis, and their association with this disease is a focus of current research. The dopamine agonist pergolide mesylate is still the mainstay of medical management, with studies on oral bioavailability, pharmacokinetics, and long-term survival rates now published. Keywords: PPID, ACTH, α-MSH, laminitis, pergolide, hypertrichosis, pars pituitary intermedia dysfunction

  7. Introduction to State-of-the-Art Test Results on PAR Performance of THAI Project

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Jae; Kim, Han Chul [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2010-10-15

    OECD/NEA THAI (Thermal hydraulics, Hydrogen, Aerosol and Iodine) Project was conducted from 2007 for three years to address open questions concerning the behavior of hydrogen, iodine and aerosols in the containment of water cooled reactors during severe accidents. In the project nine OECD member countries joined including Korea (KAERI and KINS). Recently the final report of the project was published to provide information on research results relevant to the open hydrogen and fission product issues. In this paper, major experimental results of HR (hydrogen recombiner) test series for passive autocatalytic recombiners (PARs) that can be referred to or considered in domestic R and D projects, are introduced. We quote the OECD report to obviously transfer the facts found in test series. Since new or refurbished nuclear power plants (NPPs) in Korea are considering the installation of PARs, the results obtained from HR test series may also give useful information to the licensees as well as the regulators. Therefore this paper aims for sharing the fruitful PAR related findings with Korean Nuclear Society members

  8. CFD Recombiner Modelling and Validation on the H2-Par and Kali-H2 Experiments

    Directory of Open Access Journals (Sweden)

    Stéphane Mimouni

    2011-01-01

    Full Text Available A large amount of Hydrogen gas is expected to be released within the dry containment of a pressurized water reactor (PWR, shortly after the hypothetical beginning of a severe accident leading to the melting of the core. According to local gas concentrations, the gaseous mixture of hydrogen, air and steam can reach the flammability limit, threatening the containment integrity. In order to prevent mechanical loads resulting from a possible conflagration of the gas mixture, French and German reactor containments are equipped with passive autocatalytic recombiners (PARs which preventively oxidize hydrogen for concentrations lower than that of the flammability limit. The objective of the paper is to present numerical assessments of the recombiner models implemented in CFD solvers NEPTUNE_CFD and Code_Saturne. Under the EDF/EPRI agreement, CEA has been committed to perform 42 tests of PARs. The experimental program named KALI-H2, consists checking the performance and behaviour of PAR. Unrealistic values for the gas temperature are calculated if the conjugate heat transfer and the wall steam condensation are not taken into account. The combined effects of these models give a good agreement between computational results and experimental data.

  9. uPAR as anti-cancer target: evaluation of biomarker potential, histological localization, and antibody-based therapy

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Sørensen, Tine Thurison;

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models.......Degradation of proteins in the extracellular matrix is crucial for the multistep process of cancer invasion and metastasis. Compelling evidence has demonstrated the urokinase receptor (uPAR) and its cognate ligand, the urokinase plasminogen activator (uPA), to play critical roles in the concerted...

  10. Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India

    OpenAIRE

    Chaudhry, U; Ray, K; Bala, M; Saluja, D

    2002-01-01

    Aim: To analyse mutations in the gyrA and parC genes leading to possible increase in ciprofloxacin resistance (high MIC values for ciprofloxacin) in clinical isolates of Neisseria gonorrhoeae in Delhi, India.

  11. Approaching Long Genomic Regions and Large Recombination Rates with msParSm as an Alternative to MaCS

    Science.gov (United States)

    Montemuiño, Carlos; Espinosa, Antonio; Moure, Juan C.; Vera, Gonzalo; Hernández, Porfidio; Ramos-Onsins, Sebastián

    2016-01-01

    The msParSm application is an evolution of msPar, the parallel version of the coalescent simulation program ms, which removes the limitation for simulating long stretches of DNA sequences with large recombination rates, without compromising the accuracy of the standard coalescence. This work introduces msParSm, describes its significant performance improvements over msPar and its shared memory parallelization details, and shows how it can get better, if not similar, execution times than MaCS. Two case studies with different mutation rates were analyzed, one approximating the human average and the other approximating the Drosophila melanogaster average. Source code is available at https://github.com/cmontemuino/msparsm. PMID:27721650

  12. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

    DEFF Research Database (Denmark)

    Langkilde, Anne A; Ladelund, Steen; Andersen, Ove;

    2011-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... from a general population-based prospective study.METHODS: Baseline plasma samples, baseline characteristics, and follow-up data were available from 2656 individuals from the population-based Danish MONICA10 study, followed for a median of 12.6 years. Cancer was diagnosed according to ICD-8 and ICD-10...... codes and suPAR levels were measured using a commercially available ELISA. The association of suPAR levels with incident cancer during follow-up was analyzed using Cox regression, adjusted for established risk factors and the inflammatory markers C-reactive protein (CRP) and leukocyte numbers...

  13. BIODEGRADATION DU PETROLE BRUT EN MER PAR : ENTEROBACTER CLOACAE, ESCHERICHIA COLI ET PSEUDOMONAS SPP.

    Directory of Open Access Journals (Sweden)

    A. OULD BOUDIA

    2011-01-01

    Full Text Available La pollution de la mer méditerranéenne par les rejets industriels d’origine pétrolière est l’un des problèmes de santé marine qui menace les ressources aquatiques ; parmi de nombreuses raffineries qui sont situées le long des côtes algériennes, la raffinerie d’Arzew au Nord-Ouest de l’Algérie. Le but de ce travail est la mise en évidence d'une méthode de lutte contre la pollution en utilisant des moyens biologiques représentés par le phénomène de biodégradation et ceci par la sélection des microorganismes hétérotrophes efficaces dans le traitement des effluents et des nappes d’hydrocarbures en cas d’accidents en eau de mer.L’estimation de taux de biodégradation du pétrole par les microorganismes est basée sur l’utilisation d’un respiromètre de Warburg qui permet l’analyse de la biodégradation d’échantillons via la mesure : CO2 dégagé = DCO de l’oxygène consommé lors de la réaction. Au bout du 12ème jour, nous observons des valeurs élevées pour les souches Enterobacter cloacae et Pseudomonas spp., par contre pour la souche Escherichia coli,ces valeurs sont nulles. Nous notons que le taux de fermentation le plus élevé de pétrole brute est obtenu au 12ème et au 16ème jour d’incubation, est relié individuellement à la souche de Enterobacter cloacae. La comparaison de taux de CO2, a indiqué que: Enterobacter cloacae> Pseudomonas spp.> Escherichia coli. Ceci montre que dans toutes les populations bactériennes étudiées, sauf la bactérie Enterobacter cloacae, sont capables d’assimiler les substances pétrolières.

  14. Effet getter dans des plaquettes de silicium multicristallin par diffusion de phosphore

    Science.gov (United States)

    Perichaud, I.; Martinuzzi, S.

    1992-03-01

    The external gettering effect by phosphorus diffusion is used to improve the electrical properties of multicrystalline silicon wafers. After diffusion at 900 °C for 4 h it was found that the effective diffusion lengths L_n of minority carriers achieve or overpass the thickness of the wafers. After diffusion at 850 °C for 4 h the improvements are less marked and hydrogenation is needed to obtain the same increase of L_n. SIMS analysis indicates that the gettered impurities are essentially iron, copper and nickel. Some restricted regions of the wafers are only poorly improved. It was found after chemical etching that these regions contain a high density of subgrain boundaries. The mechanism of the gettering effect used in this work is proposed, taking in account dissolved impurities in the grains and impurities segregated by dislocations. The additivity of the hydrogenation effect might be understood by the neutralisation of the recombination centers related to oxygen atoms segregated by the dislocations. L'effet getter externe par diffusion de phosphore est utilisé pour améliorer les propriétés électriques de plaquettes de silicium multicristallin. Après 4h à 900°C les longueurs de diffusion des porteurs minoritaires atteignent ou dépassent l'épaisseur des plaquettes. Après 4h à 850°C, les augmentations sont moins spectaculaires et une hydrogénation du matériau est nécessaire pour obtenir un résultat comparable au précédent. Les analyses SIMS indiquent que les impuretés extraites sont surtout du fer, du cuivre et du nickel. Certaines régions du matériau, d'extension limitée, sont toutefois peu améliorées. Elles sont caractérisées par la présence d'un réseau très dense de sous-joints. Une interprétation du mécanisme de l'effet getter observé est proposée faisant intervenir les impuretés métalliques dissoutes et celles ségrégées par les dislocations. L'additivité de l'action de l'hydrogène s'expliquerait par la neutralisation

  15. Etude par imagerie radar des pollutions pétrolières

    Directory of Open Access Journals (Sweden)

    G. Rees

    2004-06-01

    Full Text Available En Russie, chaque année, les déversements de pétrole représentent un cinquième de la production totale. Les plus importants se produisent dans le domaine périglaciaire où le milieu naturel est d’une extrême fragilité. Les pipelines sont soumis à de rudes conditions notamment à la corrosion et aux processus cryogéniques. Le risque de rupture augmente en conséquence. La surveillance des déversements d’hydrocarbures, contrainte par l’immensité et la fréquente inaccessibilité du réseau de pipelines, peut être réalisée par le recours à la télédétection. L’objectif de ce travail est de fournir, à travers l’exemple de la catastrophe d’Usinsk (Rép. de Komi survenue en 1994, des outils d’analyse des images radar. Outre leur capacité à s’affranchir du couvert nuageux, les capteurs radar apportent des informations complémentaires à celles fournies par des capteurs optiques. L’exploitation thématique de ces images est rendue difficile par un certain nombre de facteurs perturbateurs tels que les caractéristiques propres du capteur, la direction de visée, la topographie et le phénomène de chatoiement (speckle. Le travail présenté montre le rôle prépondérant joué par ces corrections qui permettent de disposer de données quantitatives comparables d’une date à une autre. La méthode mise au point ici pour le suivi temporel de l’épanchement de pétrole d’Usinsk à partir de trois images radar, est discutée notamment dans ses limites et son aspect opérationnel possible.

  16. Tanglewood度假会议中心选择PAR Springer-Miller的酒店解决方案

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    PAR Springer—Miller系统公司(PSMS)是PAR科技公司的全资子公司,同时也是领先的以顾客为中心的酒店管理系统提供商。今天PAR Springer—Miller系统公司宣布达拉斯附近Texoma湖的Tanglewood度假会议中心选择其SMSIHost酒店管理系统。

  17. Corneal topographic changes after 20-gauge pars plana vitrectomy associated with scleral buckling for the treatment of rhegmatogenous retinal detachment

    OpenAIRE

    Alexandre Achille Grandinetti; Janaína Dias; Ana Carolina Trautwein; Natasha Iskorostenski; Luciane Moreira; Ana Tereza Ramos Moreira

    2013-01-01

    PURPOSE: To evaluate the changes in corneal topography after 20-gauge pars plana vitrectomy associated with scleral buckling for the repair of rhegmatogenous retinal detachment. METHODS: Twenty-five eyes of 25 patients with rhegmatogenous retinal detachment were included in this study. 20-gauge pars plana vitrectomy associated with scleral buckling was performed in all patients. The corneal topography of each was measured before surgery and one week, one month, and three months after surgery ...

  18. Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

    Science.gov (United States)

    LaRusch, Gretchen A.; Mahdi, Fakhri; Shariat-Madar, Zia; Adams, Gregory; Sitrin, Robert G.; Zhang, Wan Ming; McCrae, Keith R.

    2010-01-01

    Factor XII (FXII) and high molecular weight kininogen (HK) mutually block each other's binding to the urokinase plasminogen activator receptor (uPAR). We investigated if FXII stimulates cells by interacting with uPAR. FXII (3-62nM) with 0.05mM Zn2+ induces extracellular signal-related kinase 1/2 (ERK1/2; mitogen-activated protein kinase 44 [MAPK44] andMAPK42) and Akt (Ser473) phosphorylation in endothelial cells. FXII-induced phosphorylation of ERK1/2 or Akt is a zymogen activity, not an enzymatic event. ERK1/2 or Akt phosphorylation is blocked upstream by PD98059 or Wortmannin or LY294002, respectively. An uPAR signaling region for FXII is on domain 2 adjacent to uPAR's integrin binding site. Cleaved HK or peptides from HK's domain 5 blocks FXII-induced ERK1/2 and Akt phosphorylation. A β1 integrin peptide that binds uPAR, antibody 6S6 to β1 integrin, or the epidermal growth factor receptor (EGFR) inhibitor AG1478 blocks FXII-induced phosphorylation of ERK1/2 and Akt. FXII induces endothelial cell proliferation and 5-bromo-2′deoxy-uridine incorporation. FXII stimulates aortic sprouting in normal but not uPAR-deficient mouse aorta. FXII produces angiogenesis in matrigel plugs in normal but not uPAR-deficient mice. FXII knockout mice have reduced constitutive and wound-induced blood vessel number. In sum, FXII initiates signaling mediated by uPAR, β1 integrin, and the EGFR to induce human umbilical vein endothelial cell proliferation, growth, and angiogenesis. PMID:20228268

  19. Leucophanaceae, nova família de Bryophyta para o Pará, Brasil Leucophanaceae, a new family of Bryophyta to Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Regina C. L Lisboa

    1997-07-01

    Full Text Available A ocorrência de Leucophanaceae, representada nos neotrópicos pela espécie Leucophanes molleri C. Müll., é registrada no estado do Pará. No Brasil, a espécie apresenta distribuição disjunta, sendo encontrada apenas nas regiões norte e sudeste. A morfologia de L. molleri é apresentada, baseada em fotomicrografias.The ocurrence of Leucophanaceae, represented in the Neotropic by Leucophanes molleri C. Müll., is presented. The disjunct distribution of the specie in the Brazil, where was collected in the north and southeast regions, it is emphasized. Also is presented the morphology of L. molleri, with photomicrographs.

  20. Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.

    Science.gov (United States)

    Cho, Nam-Chul; Cha, Ji Hyoun; Kim, Hyojin; Kwak, Jinsook; Kim, Dohee; Seo, Seung-Hwan; Shin, Ji-Sun; Kim, TaeHun; Park, Ki Duk; Lee, Jiyoun; No, Kyoung Tai; Kim, Yun Kyung; Lee, Kyung-Tae; Pae, Ae Nim

    2015-12-15

    Protease-activated receptor 2 (PAR2) is a member of G protein-coupled receptor and its activation initiates diverse inflammatory responses. Recent studies suggest that antagonists of PAR2 may provide a novel therapeutic strategy for inflammatory diseases. In this study, we have developed a series of 2-aryloxy-4-amino-quinazoline derivatives as PAR2 antagonists and examined their effects against LPS-induced inflammatory responses in RAW 264.7 macrophages. Among these derivatives, compound 2f displayed the greatest antagonistic activity with the IC50 value of 2.8μM. Binding modes of the newly identified PAR2 antagonists were analyzed by molecular docking using IFD/MM-GBSA methods in the putative binding site of PAR2 homology model. Moreover, 2f demonstrated significant inhibitory effects on the LPS-activated pro-inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) through the regulation of various intracellular signaling pathways involving nuclear factor-κB (NF-κB), activator protein 1 (AP-1) and the mitogen-activated protein kinases (MAPK). Furthermore, administration of 2f significantly reduced the mortality of LPS-induced sepsis in mice. These results provide useful insights into the development of novel PAR2 antagonists with anti-inflammatory activity in vitro and in vivo. PMID:26631441

  1. Utility of the plasma level of suPAR in monitoring risk of mortality during TB treatment.

    Directory of Open Access Journals (Sweden)

    Paulo Rabna

    Full Text Available OBJECTIVE: To investigate whether changes in the plasma level of soluble urokinase plasminogen activator receptor (suPAR can be used to monitor tuberculosis (TB treatment efficacy. DESIGN: This prospective cohort study included 278 patients diagnosed with active pulmonary TB and followed throughout the 8-month treatment period. RESULTS: Mortality during treatment was higher in the highest inclusion quartile of suPAR (23% compared to the lowest three quartiles (7%, the risk ratio being 3.1 (95% CI 1.65-6.07. No association between early smear conversion and subsequent mortality or inclusion suPAR was observed. After 1 and 2 months of treatment, an increase in suPAR compared to at diagnosis was associated with a Mortality Rate Ratio (MRR of 4.5 (95%CI: 1.45-14.1 and 2.1 (95%CI 0.62-6.82, respectively, for the remaining treatment period. CONCLUSIONS: The present study confirmed that elevated suPAR level at time of initiation of TB treatment is associated with increased risk of mortality. Furthermore, increased suPAR levels after one month of treatment was associated with increased risk of mortality during the remaining 7-month treatment period.

  2. Hydrogen concentration variation and examination of PAR installation in reactor containment building during hydrogen release from different direction failure places

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr; Bae, Kyung-Hyo

    2014-10-15

    Highlights: • Hydrogen distribution inside a nuclear containment building during SBLOCA is analyzed. • Mixture concentration variation with time is analyzed at several locations. • Performance of passive autocatalytic recombiner (PAR) is examined. - Abstract: Concentration on a hydrogen explosion mitigation strategy increased after the accident in Fukushima. A passive autocatalytic recombiner (PAR) is considered as the most realistic mitigation technology during a severe accident where electric power is lost. Hydrogen distribution and concentration might be accurately predicted because PAR must be installed in a place having a proper amount of hydrogen in order to produce positive performance. In this paper, hydrogen distributions and concentrations were predicted and analyzed during hydrogen release from different direction failure places, and then PAR installation was examined. The result shows that the hydrogen concentrations are randomly changed in the containment overall, and the behavior of hydrogen in the case of upper part failure is completely different from the case of a side part failure. It is expected that PAR works well in the area among small compartments located at the lower part of the containment building; however, the performance of PAR installed on another area is inferior.

  3. Structure par RMN d'un complexe AlcR(1-60)-ADN: Reconnaissance du petit sillon par la partie N-terminale

    Science.gov (United States)

    Cahuzac, B.; Félenbok, B.; Guittet, E.

    1999-10-01

    Aspergillus nidulans is a filamentous fungus able to use ethanol as sole energy source. The activation of the ethanol regulon genes expression is mediated by the AlcR protein. Its DNA-binding domain is located in the N-terminus (residues 1 to 60), and its NMR solution structure shows a global zinc binuclear cluster fold, with two helices in addition to the basic binuclear motif. A small number of crystallographic structures of DNA complexes of binuclear cluster proteins is yet known, and points out the major groove and the first helix as the principal sites of interaction on the DNA and the protein respectively. In this article we show evidences that the N-terminus of the protein is involved in binding to the minor groove. Aspergillus nidulans est un champignon filamenteux capable d'utiliser l'éthanol comme source unique d'énergie. La protéine AlcR est responsable de l'activation de l'expression des gènes du régulon éthanol. Le domaine de liaison à l'ADN est situé dans la partie N-terminale de la protéine (a.a. 1 à 60), et sa structure déterminée par RMN en solution montre un repliement global en bouquet binucléaire à zinc, avec deux hélices supplémentaires par rapport au motif de base. Alors que les structures déjà connues de complexes ADN - bouquets binucléaires permettent de situer dans le grand sillon la quasi-totalité des interactions, nous montrons dans la présente étude l'implication du début de la séquence dans la reconnaissance du petit sillon de l'ADN (a.a. 5 et 6).

  4. Parâmetros para avaliação do estado nutricional de ferro

    Directory of Open Access Journals (Sweden)

    Paiva Adriana A

    2000-01-01

    Full Text Available A avaliação do estado nutricional de ferro em indivíduos e populações tem sido alvo de muitas pesquisas científicas, uma vez que existem algumas questões ainda indefinidas. Através de um levantamento bibliográfico, mediante consulta às bases de dados Medline, Lilacs e Dedalus, foram selecionadas publicações científicas em português e inglês, no período de 1972 a 1998, que se referiam aos parâmetros hematológicos e bioquímicos utilizados na avaliação do estado nutricional de ferro. Os parâmetros disponíveis refletem os três diferentes estágios da carência de ferro, a qual se manifesta de forma gradual e progressiva no organismo, até o desenvolvimento da anemia ferropriva. De forma geral, não possuem boa sensibilidade e especificidade quando considerados isoladamente, apresentando vantagens e limitações que devem ser examinadas no momento da escolha. No sentido de se aumentar a sensibilidade e a especificidade do diagnóstico do estado nutricional de ferro, têm-se utilizado combinações dos diferentes parâmetros disponíveis, considerando-se a contribuição de cada um, de acordo com as características dos indivíduos estudados, as facilidades metodológicas e o custo do processo.

  5. Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells

    Directory of Open Access Journals (Sweden)

    Jaffer Shahab

    2015-03-01

    Full Text Available Apico-basal polarity is the defining characteristic of epithelial cells. In Drosophila, apical membrane identity is established and regulated through interactions between the highly conserved Par complex (Bazooka/Par3, atypical protein kinase C and Par6, and the Crumbs complex (Crumbs, Stardust and PATJ. It has been proposed that Bazooka operates at the top of a genetic hierarchy in the establishment and maintenance of apico-basal polarity. However, there is still ambiguity over the correct sequence of events and cross-talk with other pathways during this process. In this study, we reassess this issue by comparing the phenotypes of the commonly used baz4 and baz815-8 alleles with those of the so far uncharacterized bazXR11 and bazEH747 null alleles in different Drosophila epithelia. While all these baz alleles display identical phenotypes during embryonic epithelial development, we observe strong discrepancies in the severity and penetrance of polarity defects in the follicular epithelium: polarity is mostly normal in bazEH747 and bazXR11 while baz4 and baz815-8 show loss of polarity, severe multilayering and loss of epithelial integrity throughout the clones. Further analysis reveals that the chromosomes carrying the baz4 and baz815-8 alleles may contain additional mutations that enhance the true baz loss-of-function phenotype in the follicular epithelium. This study clearly shows that Baz is dispensable for the regulation of polarity in the follicular epithelium, and that the requirement for key regulators of cell polarity is highly dependent on developmental context and cell type.

  6. Improvement of DNA minicircle production by optimization of the secondary structure of the 5'-UTR of ParA resolvase.

    Science.gov (United States)

    Šimčíková, Michaela; Alves, Cláudia P A; Brito, Liliana; Prather, Kristala L J; Prazeres, Duarte M F; Monteiro, Gabriel A

    2016-08-01

    The use of minicircles in gene therapy applications is dependent on the availability of high-producer cell systems. In order to improve the performance of minicircle production in Escherichia coli by ParA resolvase-mediated in vivo recombination, we focus on the 5' untranslated region (5'-UTR) of parA messenger RNA (mRNA). The arabinose-inducible PBAD/araC promoter controls ParA expression and strains with improved arabinose uptake are used. The 27-nucleotide-long 5'-UTR of parA mRNA was optimized using a predictive thermodynamic model. An analysis of original and optimized mRNA subsequences predicted a decrease of 8.6-14.9 kcal/mol in the change in Gibbs free energy upon assembly of the 30S ribosome complex with the mRNA subsequences, indicating a more stable mRNA-rRNA complex and enabling a higher (48-817-fold) translation initiation rate. No effect of the 5'-UTR was detected when ParA was expressed from a low-copy number plasmid (∼14 copies/cell), with full recombination obtained within 2 h. However, when the parA gene was inserted in the bacterial chromosome, a faster and more effective recombination was obtained with the optimized 5'-UTR. Interestingly, the amount of this transcript was 2.6-3-fold higher when compared with the transcript generated from the original sequence, highlighting that 5'-UTR affects the level of the transcript. A Western blot analysis confirmed that E. coli synthesized higher amounts of ParA with the new 5'-UTR (∼1.8 ± 0.7-fold). Overall, these results show that the improvements made in the 5'-UTR can lead to a more efficient translation and hence to faster and more efficient minicircle generation. PMID:27147534

  7. Phenoseasonal variability of subcanopy PAR and the effects of photointensity and photoperiod on the physiological ecology of Lindera benzoin

    Science.gov (United States)

    Hudson, J. E.; Levia, D. F., Jr.; Hudson, S.; Bais, H.; Legates, D. R.

    2015-12-01

    This work represents a novel approach to measuring photosynthetic photon flux density (PPFD), and spatiotemporal light dynamics, by utilizing an instrument capable of providing a 15-second spatially-integrated one meter linear average of the PPFD, obtaining measurements at multiple locations and elevations in the subcanopy over a full year for all cloud conditions. Nearly 4,600 individual observations of photosynthetically active radiation (PAR, 400-700 nm) were made over the seven phenoseasons of a deciduous forest in the Piedmont Region, Maryland. Additionally, to quantify of the effect of various photointensities on the physiological ecology of Lindera benzoin L. Blume (northern spicebush) grown in the lab, health was determined by monitoring physical growth and biomass, and by UV-vis spectrophotometry analysis of leaf extract. Results show understory PAR is typically less than 40% of open PAR. Leafless subcanopy PAR values were almost 10 times higher than leafed season PAR, and sunflecks often three orders of magnitude higher than mean subcanopy PAR during the leafed season. Phenoseason is responsible for nearly three-quarters of the variation between plant canopy levels. Spicebush growth occurred at study locations receiving higher incidence of PAR (> 64th percentile). UV-vis spectrophotometry analysis showed significant differences in root to shoot ratios, biomass, initial stomatal conductance, chlorophyll a and b, and carotenoids. Spicebush under lab conditions significantly alter their biomass and individual pigments and pigment ratios in response to high intensity light conditions. Results suggest temporal light sequences in the field may be a very important factor in the functional ecology of northern spicebush.

  8. CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo.

    Directory of Open Access Journals (Sweden)

    Alexia Rabilotta

    Full Text Available In the C. elegans embryo, formation of an antero-posterior axis of polarity relies on signaling by the conserved PAR proteins, which localize asymmetrically in two mutually exclusive groups at the embryonic cortex. Depletion of any PAR protein causes a loss of polarity and embryonic lethality. A genome-wide RNAi screen previously identified two B-type cyclins, cyb-2.1 and cyb-2.2, as suppressors of par-2(it5ts lethality. We found that the loss of cyb-2.1 or cyb-2.2 suppressed the lethality and polarity defects of par-2(it5ts mutants and that these cyclins act in cell polarity with their cyclin-dependent kinase partner, CDK-1. Interestingly, cyb-2.1; cyb-2.2 double mutants did not show defects in cell cycle progression or timing of polarity establishment, suggesting that they regulate polarity independently of their typical role in cell cycle progression. Loss of both cyclin genes or of cdk-1 resulted in a decrease in PAR-6 levels in the embryo. Furthermore, the activity of the cullin CUL-2 was required to achieve suppression of par-2 lethality when both cyclins were absent. Our results support a model in which CYB-2.1/2/CDK-1 antagonize CUL-2 activity to promote stabilization of PAR-6 levels during polarization of the early C. elegans embryo. They also suggest that CYB-2.1 and CYB-2.2 contribute to the coupling of cell cycle progression and asymmetric segregation of cell fate determinants.

  9. The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4.

    Science.gov (United States)

    Du, William W; Li, Xianmin; Li, Tianbi; Li, Haoran; Khorshidi, Azam; Liu, Fengqiong; Yang, Burton B

    2015-01-15

    The microRNA miR-17-92 cluster plays a fundamental role in heart development. The aim of this study was to investigate the effect of a member of this cluster, miR-17, on cardiac senescence. We examined the roles of miR-17 in senescence and demonstrated that miR-17-3p attenuates cardiac aging in the myocardium by targeting Par4 (also known as PAWR). This upregulates the downstream proteins CEBPB, FAK, N-cadherin, vimentin, Oct4 and Sca-1 (also known as stem cell antigen-1), and downregulates E-cadherin. Par4 has been reported as a tumor suppressor gene that induces apoptosis in cancer cells, but not in normal cells. Repression of Par4 by miR-17-3p enhances the transcription of CEBPB and FAK, which promotes mouse cardiac fibroblast (MCF) epithelial-to-mesenchymal transition (EMT) and self-renewal, resulting in cellular senescence and apoptosis resistance. We conclude that Par4 can bind to the CEBPB promoter and inhibit its transcription. Decreased Par4 expression increases the amount of CEBPB, which binds to the FAK promoter and enhances FAK transcription. Par4, CEBPB and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT and self-renewal. Through this novel senescence signaling axis, miR-17-3p represses Par4 expression, acting pleiotropically as a negative modulator of cardiac aging and cardiac fibroblast cellular senescence. PMID:25472717

  10. Valor en riesgo (VeR): concepto, parámetros y utilidad

    OpenAIRE

    José Manuel Feria Domínguez; María Dolores Oliver Alfonso

    2006-01-01

    Hoy en día, el Valor en Riesgo (VeR) constituye una herramienta esencial en la medición y control del riesgo de mercado. Para asegurar una correcta interpretación de la cifra VeR por parte de usuarios potenciales (reguladores, accionistas, gestores de riesgo, etc.), es preciso la definición previa de una serie de parámetros como el nivel de confianza, el período de mantenimiento, la moneda de referencia y la metodología de estimación empleada. En este trabajo, nos centramos en el ...

  11. La Escuela Infantil: propuesta inclusiva para un alumno con parálisis cerebral

    OpenAIRE

    Torras-Velasco, Silvia

    2015-01-01

    Este Trabajo Fin de Grado pretende aportar una propuesta de intervención para el primer ciclo de Educación Infantil en un entorno inclusivo. A partir de actividades de estimulación sensorial se busca la plena participación de todos los alumnos del grupo, incluido un alumno con parálisis cerebral. En un primer momento se realiza una búsqueda bibliográfica sobre los distintos aspectos que nos ocupan: evolución y desarrollo infantil (0-3 años), características principales de los niños que presen...

  12. 参加Euro—Par2006国际会议总结

    Institute of Scientific and Technical Information of China (English)

    洪文董; 王彬

    2007-01-01

    Euro—Par是欧洲并行计算年会的简称,这一会议是1995年通过合并了CONPAR—VAPP(并行与向量处理国际会议)和PARLE(欧洲并行体系结构与语言会议)这两个系列会议形成的。Euro—Par每年召开一次,由欧洲各国的大学、研究机构轮流主办,称为Euro—Par系列年会(Euro-Par annualseries)。

  13. Commande d'un actionneur électrique par communication sans fil Zigbee

    OpenAIRE

    LLIBRE, Jean-François

    2010-01-01

    CNR IUT Angers 2010 Nous présentons ici un asservissement de position en sans fil d'un moteur à courant continu. La consigne élaborée au niveau d'un PC distant est envoyée via un module Zigbee à un autre module Zigbee, qui lui relié au moteur à commander, renvoie la mesure de la position. La commande numérique mise en œuvre doit être suffisamment robuste et la période d'échantillonnage judicieusement choisie pour s'affranchir des contraintes imposées par la communication hertzienne. Nous u...

  14. Fast Na+ spike generation in dendrites of guinea-pig substantia nigra pars compacta neurons

    DEFF Research Database (Denmark)

    Nedergaard, S; Hounsgaard, Jørn Dybkjær

    1996-01-01

    Electric fields were applied to study the regenerative properties of substantia nigra pars compacta neurons in guinea-pig brain slices. Two types of spikes, of high or low amplitude, were generated in both the soma-hyperpolarizing and the soma-depolarizing directions of the field. The different...... by synaptic stimulation and, in some neurons, low-amplitude spikes were generated by synaptic potentials in the absence of field application. These results suggest that channels responsible for Na+ spike generation reside in the dendrites, and are influenced by spatially distributed voltage-dependent K...

  15. Linfoma primario bilateral de la glándula parótida

    OpenAIRE

    Mena Domínguez, Eduardo Antonio; Torres Morientes, Luis M.; Millás Gómez, Teresa; Tavárez Rodríguez, Juan José; Bauer, Michael; Morais Pérez, Darío

    2012-01-01

    [ES] Los linfomas primarios de las glándulas salivales representan menos del 1% de todos los linfomas no Hodgkin (LNH). Se presentan entre los 50 y 80 años, con predominio claro en mujeres y en la glándula parótida. La mayoría de los casos son localizados (estadios I-II: 75- 100%), y presentan síntomas debido a la aparición de una tumoración en la glándula afectada, generalmente indolora. [EN] Primary Lymphoma of the salivary glands represent less than 1% of all non-Hodgkin's ...

  16. Geometría epipolar de un par fotogramétrico

    OpenAIRE

    Aldeguer Lima, Elena

    2011-01-01

    Este proyecto final de carrera consiste en el remuestreo de los fotogramas de un bloque fotogramétrico para que cada par, presente geometría epipolar. Se parte de la suposición de que la orientación externa (triangulación aérea) está ya hecha y que disponemos de los fotogramas originales del vuelo. En este trabajo se han implementado funciones, programadas en lenguaje en C, que modifican la geometría de los fotogramas. Se han desarrollado las ecuaciones de colinealidad y dos...

  17. La prévention de l’infection par le virus respiratoire syncytial

    OpenAIRE

    Samson, L

    2009-01-01

    L’infection par le virus respiratoire syncytial (VRS) est la principale cause d’infection des voies respiratoires inférieures chez les jeunes enfants et pour cette raison, bon nombre des prématurés et des enfants présentant d’autres facteurs de risque doivent être hospitalisés chaque année au Canada. Le palivizumab, un anticorps monoclonal anti-VRS, peut réduire le taux d’hospitalisation et la gravité de la maladie d’un petit groupe de prématurés ou de nourrissons à haut risque pendant leur p...

  18. Modèle de traduction statistique à fragments enrichi par la syntaxe

    OpenAIRE

    Nikoulina, Vassilina

    2010-01-01

    Les modèles de traduction automatique probabiliste traditionnel ignorent la structure syntaxique des phrases source et cible. Le choix des unités lexicales cible et de leur ordre est contrôlé uniquement par des statistiques de surface sur le corpus d'entraînement. La connaissance de la structure linguistique peut-être bénéfique, car elle fournit des informations génériques compensant la pauvreté des données directement observables. Nos travaux ont pour but d'étudier l'impact des informations ...

  19. Atypical presentation of acute-onset endophthalmitis after uncomplicated pars plana vitrectomy.

    Science.gov (United States)

    Reilly, Gayatri S; Garfinkel, Richard A; Melamud, Alexander

    2015-03-01

    A 70-year-old woman presented with signs of acute-onset endophthalmitis within 24 hours of surgery, with retinal hemorrhages and vascular changes in the absence of pain or significant inflammation. She had undergone uncomplicated 25-gauge pars plana vitrectomy for epiretinal membrane with presenting visual acuity of 20/40- and significant distortion. Vitreous culture revealed Staphylococcus epidermidis. Final visual acuity was no light perception with persistent pain, and the patient ultimately underwent enucleation. Although rarely, acute-onset postoperative endophthalmitis can present as retinal vasculitis with intraretinal hemorrhages and mild inflammation. PMID:25856829

  20. A prospective study on postoperative discomfort after 20-gauge pars plana vitrectomy

    OpenAIRE

    Yu JG; Ni F; Xiang Y; Feng YF; Wang J.; Fu XA

    2015-01-01

    Ji-guo Yu,1,* Fang Ni,1,* Yi Xiang,1 Yi-fan Feng,2 Jue Wang,1 Xun-an Fu11Department of Ophthalmology, the Central Hospital of Wuhan, Wuhan, Hubei Province, 2Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workPurpose: To evaluate postoperative pain and other irritation symptoms after 20-gauge (20G) pars plana vitrectomy.Materials and methods: A total of 110 consecutive patients...

  1. Efecto antifúngico de hidrodestilados de Zingiber officinale Roscoe sobre Moniliophthora roreri (Cif&Par)

    OpenAIRE

    José Gregorio Joya-Dávila; Sandra Isabel Ramírez-González; Orlando López-Báez; Álvaro Enrique Alvarado-Gaona

    2015-01-01

    La moniliasis, ocasionada por el hongo Moniliophthora roreri (Cif. & Par), es la principal enfermedad del cacao en Latinoamérica, y las medidas para su manejo sostenible son aún escasas. Con base en reportes previos, el objetivo de este trabajo fue optimizar el proceso de extracción por destilación de Zingiber officinale, evaluando in vitro su efecto antifúngico sobre conidias de M. roreri. Se elaboraron ocho hidrodestilados con material fresco (300 y 600 g/L) y seco al sol (45 y 90 g/L), con...

  2. La prise en charge des suicides par précipitation en traumatologie

    Directory of Open Access Journals (Sweden)

    Abdelmajid Elmrini

    2010-09-01

    Full Text Available OBJECTIFS: A travers ce travail, l’épidémiologie et la psychopathologie du suicide par précipitation seront rappelées, le rôle du chirurgien traumatologue dans la restauration physique et psychique sera démontré. METHODES: Nous rapportons une étude rétrospective de 15 suicidants par précipitation admis pour des traumatismes complexes de l’appareil locomoteur entre 2004 et 2007. RESULTATS: Il s’agissait de primosuicidants, comprenant 10 femmes et 5 hommes. L’âge moyen des hommes est de 26,5 ans (24-34 ans et celui des femmes de 40,7 ans (17-45 ans. Le bilan lésionnel des suicidants a retrouvé 14 fractures des membres inférieurs, 4 traumatisme du rachis avec compression médullaire dans 1 cas, une fracture du bassin; deux traumatismes du membre supérieur. Aucun de ces patients n’a présenté de lésions viscérales ni de traumatismes crâniofacial. 80% (n = 12 des patients souffraient d’une affection psychiatrique avant leur passage à l’acte suicidaire : 8 pour une pathologie dépressive et 4 pour une schizophrénie. Chaque suicidant a subi au moins un acte chirurgical. Tous les patients avaient poursuivi la prise en charge psychiatrique en ambulatoire. Nos résultats fonctionnels étaient satisfaisants sans complications. Aucun des patients n’a récidivé. La pathologie suicidaire représente un problème de santé publique. Le suicide par précipitation représente 5 % de l’ensemble des modalités suicidaires. Les traumatismes occasionnés par ce mode suicidaire sont complexes et graves. Leur prise en charge nécessite une collaboration multidisciplinaire. CONCLUSION: La réparation chirurgicale permet à la fois le rétablissement de la fonction et l’amélioration psychique du sujet prévenant contre une rechute dépressive ou une récidive suicidaire.

  3. Anuran amphibians of the urban region of Altamira (Oriental Amazonia, state of Pará, Brazil.

    Directory of Open Access Journals (Sweden)

    Flávio Bezerra Barros

    2009-06-01

    Full Text Available The present study aimed to take stock of the species of anurans in three localities of the urban region of Altamira, a municipal district in the west of the state of Pará (Oriental Amazonia. Collections were made between January and June of 2004. Fifteen species were recorded during the study. The family Hylidae was the most represented, with eight species. The data was compatible with the degree of conservation of the collection areas. The necessity of making new fauna inventories in all Brazilian biomes is of extreme urgency, particularly in the Amazon, given its vast extension and lack of inventories.

  4. Permeabilidad dentinaria. Relación entre los distintos parámetros que la definen

    OpenAIRE

    Del-Nero Beneitez, María Olga; Conejo Fernández, Belén; Macorra García, José Carlos de la

    1997-01-01

    Mediante un sistema simulado de perfusión, se mide la permeabilidad de discos de dentina. Se estudia la relación entre el área y el espesor de la dentina a través de la cual se perfunde, y la magnitud del gasto (volúmen/tiempo). Debido principalmente a la variabilidad anatómica, no es posible establecer una relación estadísticamente significativa entre dichos parámetros. El radio efectivo medio calculado (p

  5. Parálisis cerebral infantil: tóxina botulínica y fisioterapia

    OpenAIRE

    Frías González, Laura

    2014-01-01

    La Parálisis Cerebral Infantil es una encefalopatía secular con afectación predominantemente motriz, que consiste en una variada combinación de espasticidad, ataxia, distonía y otras discinesias [1]. La espasticidad es la mayor causante de discapacidad física, por lo que su tratamiento va a ser de vital importancia en los niños que la presentan. Para ello hay diferentes técnicas que podemos llevar a cabo, aunque siempre debemos tener en cuenta las características individuale...

  6. Intervención Socioemocional en Parálisis Cerebral mediante plaphoons

    OpenAIRE

    Serna Olmedo, Laura

    2013-01-01

    Este trabajo se centra en los aspectos socioemocionales en personas con parálisis cerebral infantil, profundizando en el desarrollo de los rasgos personales y emocionales de las personas que presentan esta discapacidad, con la finalidad de diseñar e implementar un programa de intervención a cinco alumnos con P.C.I con discapacidad intelectual en diferente grado. Para ello y mediante una metodología práctica, las actividades que desarrollan; la autoconciencia emocional, la autogestión emociona...

  7. Intervención educativa: alumnos con discapacidad motora (parálisis cerebral infantil)

    OpenAIRE

    Valencia Navajas, Jesús

    2015-01-01

    La parálisis cerebral ofrece al profesional un campo de intervención amplísimo, con el fin de facilitar la tarea reeducativa en esta área. Realizo este trabajo, concentrado en distintas actividades, ideadas en algunos casos por diferentes autores, y en otros casos, diseñadas en base al ejercicio profesional. Cuando nos disponemos a reeducar disfunciones neurológicas y musculares, partimos de un diagnóstico, arriesgamos un pronóstico y aplicamos una terapia. Esta elección supone una reflexi...

  8. Avances en sistremas interactivos para personas con parálisis cerebral

    OpenAIRE

    Mauri Loba, César

    2014-01-01

    La Paràlisi Cerebral és la discapacitat motora més comuna durant la infància i consisteix en una alteració de la mobilitat deguda a una lesió en el sistema nerviós central produïda durant l'etapa prenatal, perinatal o infantil. Aquestes lesions, que no són una malaltia, no evolucionen, però les seves conseqüències sí que interfereixen en el desenvolupament de la persona. Les dificultats motores, que solen anar acompanyades en moltes ocasions per problemes sensorials, alteracions en l'atenció,...

  9. Estudio de necesidades de las personas con parálisis cerebral

    OpenAIRE

    SIIS-Centro de Documentación y Estudios

    1997-01-01

    Los objetivos de este estudio son los siguientes: Identificar, en la medida de lo posible, todos los casos de parálisis cerebral controlados en los registros del Instituto Foral de Bienestar Social, la Asociación Pro Deficientes Mentales de Álava, la Asociación de Paralíticos Cerebrales y del Departamento de Educación del Gobierno Vasco. Conocer la situación funcional y ocupacional de estas personas, su forma de vida y sus necesidades con respecto a los servicios, accesibili...

  10. Tratamientos de la espasticidad en niños con parálisis cerebral

    OpenAIRE

    Abascal Diego, Estefanía

    2014-01-01

    RESUMEN: Objetivo: El objetivo de esta revisión sistemática fue estudiar que tratamientos y técnicas son las que tienen más evidencia científica en la actualidad para modular el tono en niños con Parálisis Cerebral infantil (PCI). Del mismo modo, como objetivo secundario, se quiso abordar y hacer una propuesta de futuras investigaciones hacia la terapia familiar y adaptación del entorno Fuentes de datos y selección de los estudios: Los estudios fueron buscados en la literatura en cuatro ba...

  11. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    OpenAIRE

    Ravshan Burikhanov; Tripti Shrestha-Bhattarai; Nikhil Hebbar; Shirley Qiu; Yanming Zhao; Gerard P. Zambetti; Vivek M. Rangnekar

    2014-01-01

    The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice...

  12. Harmonia vocàlica: paràmetres i variació

    OpenAIRE

    Jiménez, Jesús; Lloret, Maria-Rosa

    2011-01-01

    L'harmonia vocàlica és un fenomen assimilatori que comporta, en general, beneficis articulatoris per a l'emissor i beneficis perceptius per al receptor, tot i que aquests guanys vénen acompanyats per l'afebliment o fins i tot per l'eliminació de propietats subjacents de les vocals harmonitzades. Per aquest motiu, els paràmetres que regulen l'extensió dels trets propagats han de determinar, en cada cas, quines són les causes que afavoreixen la igualació malgrat la pèrdua d'informació concomita...

  13. Comprendre le développement professionnel par l’analyse des discours

    OpenAIRE

    Vanhulle, Sabine

    2011-01-01

    Dans un dispositif consacré au développement professionnel, nos étudiants en enseignement secondaire tiennent un portfolio. Celui-ci se clôture par un récit de trajectoire. Notre recherche réside dans l’analyse de ces récits à partir d’une grille d’indicateurs linguistiques. Ces indicateurs nous informent sur les processus réflexifs et discursifs à l’œuvre dans l’élaboration de savoirs professionnels. Ce premier niveau de description conduit à une méthode de recherche herméneutique. Il s’agit...

  14. Parámetros hormonales e inflamatorios en un grupo de mujeres con sobrepeso/obesidad

    OpenAIRE

    Loria-Kohen, Viviana; Gómez-Candela, Carmen; Fernández Fernández, Ceila; Zurita Rosa, Laura; Palma-Milla, Samara; M. Urbieta; Bermejo López, Laura M.

    2011-01-01

    Introducción y Objetivos: Recientemente se ha descubierto que la obesidad es una patología caracterizada por un estado crónico de inflamación leve. El objetivo de este estudio fue describir la situación hormonal e inflamatoria de un colectivo de mujeres con sobrepeso/obesidad. Pacientes y métodos: se incluyeron mujeres > 18 años, con IMC ≥ 25 < 40 kg/m2. Se recogieron datos socio-sanitarios, presión arterial, parámetros antropométricos, de actividad física, estudio bio...

  15. WebParF:A Web Partitioning Framework for Parallel Crawler

    OpenAIRE

    Sonali Gupta; Komal Bhatia; Pikakshi Manchanda

    2013-01-01

    With the ever proliferating size and scale of the WWW [1], efficient ways of exploring content are of increasing importance. How can we efficiently retrieve information from it through crawling? And in this “era of tera” and multi-core processors, we ought to think of multi-threaded processes as a serving solution. So, even better how can we improve the crawling performance by using parallel crawlers that work independently? The paper devotes to the fundamental development in the field of par...

  16. Etude de fusibles industriels par tomographie X // X-Ray tomography analysls of industrial fuses

    OpenAIRE

    Rouèche, Emilie; Thomas, Gérard; Missiaen, Jean-Michel; Gelet, Jean-Louis

    2005-01-01

    National audience Le procédé d'élaboration des fusibles Ferraz-Shawmut comprend une étape de remplissage d'une matrice céramique avec du sable soumis à des vibrations. Pour mieux contrôler cette étape, une étude a été lancée pour analyser les variations de la microstructure d'empilement vibrés de grains de sable par Tomographie X. La tomographie X est une technique d'analyse non destructive permettant d'obtenir simplement des informations tridimensionnelles au coeur des échantillons. Les o...

  17. uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells

    OpenAIRE

    MALLA, RAMA RAO; Gopinath, Sreelatha; Alapati, Kiranmai; Gorantla, Bharathi; Christopher S Gondi; Rao, Jasti S.

    2012-01-01

    Glioblastomas present as diffuse tumors with invasion into normal brain tissue and frequently recur or progress after radiation as focal masses because of glioma-initiating cells. The role of the urokinase-type plasminogen activator receptor (uPAR) and cathepsin B in stem-like phenotype has been extensively studied in several solid tumors. In the present study, we demonstrated that selection of glioma-initiating cells using CD133 expression leads to a specific enrichment of CD133+ cells in bo...

  18. Les paradoxes des distances dans la construction des identités alimentaires par acculturation

    OpenAIRE

    Marc Dedeire; Selma Tozanli

    2008-01-01

    À partir d’une problématique issue d’observations et de lectures sur la mobilité des hommes, le(s) distance(s) et l’ancrage territorial, nous nous interrogeons sur les paradoxes de l’acculturation dans la (re)construction des identités alimentaires. Pourquoi certaines populations développent-elles leur culture alimentaire locale dans des territoires d’accueil ? Quel est le rôle du migrant et de la distance sur cette diffusion appuyée par l’acculturation ? Et quelles sont les formes d’ancrages...

  19. ETUDE D'IONS MULTICHARGES DANS LES PLASMAS PRODUITS PAR LASER

    OpenAIRE

    Jaeglé, P.; Carillon, A.; Jamelot, G.; Wehenkel, C.; Sureau, A.; Guennou, H.

    1980-01-01

    Parmi les plasmas chauds, les plasmas produits par laser ont pour caractéristiques une densité maximum très élevée, présentant un fort gradient spatial, et une variation temporelle rapide de la température et de la densité. L'étude du rayonnement des ions multichargés, nécessaire pour les diagnostics sur ces paramètres, offre à la physique atomique champ de recherche original comprenant notamment l'identification de raies non-observées dans d'autres conditions, d'importantes modifications du ...

  20. Influencia de los parámetros nutricionalesen cirugía de cadera

    OpenAIRE

    Montero Furelos, Luis Angel; Yáñez Calvo, J.; Hernández Blanco, M.; Ferreiros Domínguez, O.; Pedrós Cuadrillero, L.

    1997-01-01

    Bajo la hipótesis de que los parámetros nutricionales influyen en el desarrollo perioperatorio de la cirugía de cadera realizamos un estudio prospectivo observacional de tipo clínico sobre 100 pacientes con una edad media de 76 años. Realizamos una evaluación clínica al ingreso: talla, peso, pliegue cutáneo, circunferencia braquial y muscular. Medición de proteínas plasmáticas y linfocitos totales al ingreso, en el postoperatorio y cada 7 días. Definimos los pacientes según los...