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Sample records for cellule epitheliale intestinale

  1. Cellulitis

    Science.gov (United States)

    ... insect bite. What are the complications of preseptal cellulitis? Infection can spread posteriorly into the orbit or other ... there is generally full recovery. What causes orbital cellulitis? Spread of infection is the most common cause of orbital cellulitis. ...

  2. M(E)CANISMES MOL(E)CULAIRES IMPLIQU(E)S DANS L'ALT(E)RATION DU PH(E)NOTYPE DES CELLULES (E)PITHELIAL(E)S TUBULAIRES PAR LES CALPA(I)NES EXTRACELLULAIRES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wen-hui; Joelle Perez; Laurent Baud

    2008-01-01

    Objectif Rechercher les mécanismes moléculaires par lesquels des calpaines extracellulaires af-fectent l'adhérence et la mobilité des cellules épithéliales HK-2 dérivées du tubule proximal humain. Méthodes Western blot pour détecter le clivage des chaines α des intégrines; dosage radioimmunologique pour mesurer l' AMP cyclique intracellulaire; fluorescence-activated cell sorting (FACS) pour tester l' apoptose cellulaire. La morpholo-gie des cellules HK-2 a été observée et photographiée. Résultats (1) L ' exposition des cellules HK-2 à la calpaine μ n'a pas entrainé de clivage des chaines o3 et αV des intégrines; (2)l' exposition des cellules HK-2 à la calpaine μ entrainait une augmentation progressive de l' accumulation intracellulaire d' AMP cyclique (P<0.05) qui était associée une résistance cellulaire à l'apoptose(P <0. 05 ) ; (3)l'addition d'un inhibiteur pharmacologique de la protéine kinase A(PKA) prévenait totalement les modifications d'adhérence et de mobilité cellulaires induites par calpaine μ Conclusion Les calpaines externalisées peuvent modifier l' adherence et la mobilité cellulaires via un mécanisme qui implique l'accumulation d' AMP cyclique et l' activation de la PKA. Par ces mécanismes, les calpaines externalisées pourraient jouer un role dans l'induction de la réparation au cours de l'insuffucance rénale aiguё.

  3. Effects of the ionising radiations on the structure and the function of the intestinal epithelial cell; Effets des rayonnements ionisants sur la structure et la fonction de la cellule epitheliale intestinale

    Energy Technology Data Exchange (ETDEWEB)

    Haton, C

    2005-06-15

    The intestinal mucosa is a particularly radio-sensitive tissue and damage may occur following either accidental or therapeutic exposure. the deleterious actions of ionizing radiation are linked to the formation of sometimes overwhelming quantities of reactive oxygen species (R.O.S.). Production of R.O.S. is both direct and indirect from the secondary effects of irradiation. A better comprehension of the underlying mechanisms of injury will lead to more adapted therapeutic approaches to limit the harmful effects of irradiation. The homeostasis of the intestinal epithelium is regulated by three factors: proliferation, apoptosis and differentiation. these three factors were studied using the cell model, HT29, in order to analyze modulations of this balance after irradiation. our results, in agreement with other data, showed the establishment of mitotic delay. This arrest of proliferation was followed by apoptosis to be the major mechanism leading to cell death in this model. thus, for the first time, we have shown that irradiated intestinal epithelial cells preserve their capacity to differentiate. This indicates, although indirectly, that intestinal cells have and preserve an intrinsic capacity restore a functional epithelium. R.O.S. are considered as intermediates between the physical nature of radiations and biological responses. It seems essential to understand anti-oxidant mechanisms used by the cell for defence against the deleterious effects of R.O.S post exposure. This study of several anti-oxidant defence mechanisms of intestinal mucosa, was carried out in vivo in the mouse at different times following abdominal irradiation. We observed an early mitochondrial response in the hours following irradiation revealing this organelle as a particular target. We demonstrated a strong alteration of anti-oxidant capacity as revealed by a decrease in S.O.D.s, catalase and an increase of the G.P.X.s and M.T.s. A part of these modifications appeared to depend on an irradiation-induced inflammatory response. Finally, we showed that the loss of catalase is linked to the onset of structural damage to the mucosa. All of these results orient therapeutic strategies towards inducing the proliferation of crypt cells, rather than an inhibition of apoptosis, since the epithelial cells retain differentiation capacity and so production of functional cells. (aut0009h.

  4. Orbital cellulitis

    Science.gov (United States)

    ... hemolytic streptococci may also cause orbital cellulitis. Orbital cellulitis infections in children may get worse very quickly and ... in the space around the eye. An orbital cellulitis infection can get worse very quickly. A person with ...

  5. Preseptal Cellulitis, Orbital Cellulitis, Orbital Abscess

    OpenAIRE

    Rana Altan Yaycıoğlu

    2012-01-01

    Patients with orbital infections present to our clinic usually with unilateral pain, hyperemia, and edema of the eyelids. The differentiation between preseptal and orbital cellulitis is utmost important in that the second requires hospitalization. Since in orbital cellulitis, the tissues posterior to the orbital septum are involved, signs such as conjunctival chemosis, limited eye movement, decreased vision, as well as afferent pupil defect secondary to optic nerve involvement may al...

  6. Preseptal and orbital cellulitis

    OpenAIRE

    Emine Akçay; Gamze Dereli Can; Nurullah Çağıl

    2014-01-01

    Preseptal cellulitis (PC) is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC) is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites) or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epid...

  7. Is Cellulitis Contagious?

    Science.gov (United States)

    ... isn't usually spread from person to person. Cellulitis is an infection of the deeper layers of the skin most ... chills Swollen glands or lymph nodes Left untreated, cellulitis can rapidly ... soft tissue infections. In: Rosen's Emergency Medicine: Concepts and Clinical Practice. ...

  8. Tonsillar Cellulitis and Abscess

    Science.gov (United States)

    ... Vocal Cord Contact Ulcers Vocal Cord Paralysis Tonsillar cellulitis is a bacterial infection of the tissues around the tonsils. A tonsillar ... Laryngoceles Retropharyngeal Abscess Salivary Gland Disorders Submandibular ... and Tonsillar Abscess Tonsillopharyngitis Vocal Cord Polyps, Nodules, ...

  9. Preseptal Cellulitis, Orbital Cellulitis, Orbital Abscess

    Directory of Open Access Journals (Sweden)

    Rana Altan Yaycıoğlu

    2012-12-01

    Full Text Available Patients with orbital infections present to our clinic usually with unilateral pain, hyperemia, and edema of the eyelids. The differentiation between preseptal and orbital cellulitis is utmost important in that the second requires hospitalization. Since in orbital cellulitis, the tissues posterior to the orbital septum are involved, signs such as conjunctival chemosis, limited eye movement, decreased vision, as well as afferent pupil defect secondary to optic nerve involvement may also be observed. Prompt intravenous antibiotic treatment should be started, and surgical drainage may be performed if patient shows failure to improve in 48 hours despite optimal management. Without treatment, the clinical course may progress to subperiosteal or orbital abscess, and even to cavernous sinus thrombosis. (Turk J Ophthalmol 2012; 42: Supplement 52-6

  10. Necrobiosis lipoidica mimicking cellulitis

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    Joshi A

    1997-01-01

    Full Text Available A 57-year-old obese patient presented with a 5 month history of tender, indurated, erythematous plaques with superficial ulceration on the right shin. The lesions closely mimicked cellulitis but were unresponsive to antibiotics. Though the patient was not a known diabetic, on investigations she was found to be a diabetic. Histology confirmed the diagnosis of necrobiosis lipoidica. This acutely inflammed presentation of necrobiosis lipoidica is extremely rare.

  11. Eosinophilic cellulitis and dermographism.

    Science.gov (United States)

    Nguyen, Nathalie Q; Ma, Linglei

    2005-12-30

    A 26-year-old man presented with a history of intermittent erythematous plaques on his hands and legs. A peripheral blood eosinophilia was noted. Histopathologic examination showed numerous eosinophils and characteristic flame figures. The clinical presentation and histopathologic alterations are consistent with the diagnosis of Wells' syndrome, which is also known as eosinophilic cellulitis. Wells' syndrome is a rare condition of unclear etiology. We discuss its diagnosis and possible association with other conditions that manifest peripheral eosinophilia.

  12. Preseptal and orbital cellulitis

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    Emine Akçay

    2014-09-01

    Full Text Available Preseptal cellulitis (PC is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, Haempphilus influenzae, Moraxella catarrhalis and S. pyogenes. The method for the diagnosis of OS and PS is computed tomography. Using effective antibiotics is a mainstay for the treatment of PC and OC. There is an agreement that surgical drainage should be performed in cases of complete ophthalmoplegia or significant visual impairment or large abscesses formation. This infections are also at a greater risk of acute visual loss, cavernous sinus thrombosis, meningitis, cerebritis, endophthalmitis, and brain abscess in children. Early diagnosis and appropriate treatment are crucial to control the infection. Diagnosis, treatment, management and complications of PC and OC are summarized in this manuscript. J MicrobiolInfect Dis 2014; 4(3: 123-127

  13. Odontogenic Facial Cellulitis

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    Yordany Boza Mejias

    2012-11-01

    Full Text Available Background: odontogenic facial cellulitis is an acute inflammatory process manifested in very different ways, with a variable scale in clinical presentation ranging from harmless well defined processes, to diffuse and progressive that may develop complications leading the patient to a critical condition, even risking their lives. Objective: To characterize the behavior of odontogenic facial cellulitis. Methods: A descriptive case series study was conducted at the dental clinic of Aguada de Pasajeros, Cienfuegos, from September 2010 to March 2011. It included 56 patients who met the inclusion criteria. Variables analyzed included: sex, age, teeth and regions affected, causes of cellulite and prescribed treatment. Results: no sex predilection was observed, lower molars and submandibular anatomical region were the most affected (50% and 30 4% respectively being tooth decay the main cause for this condition (51, 7%. The opening access was not performed to all the patients in the emergency service. The causal tooth extraction was not commonly done early, according to the prescribed antibiotic group. Thermotherapy with warm fomentation and saline mouthwash was the most prescribed and the most widely used group of antibiotics was the penicillin. Conclusions: dental caries were the major cause of odontogenic cellulite. There are still difficulties with the implementation of opening access.

  14. Understanding pediatric bacterial preseptal and orbital cellulitis

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    Gonzalez Mithra

    2010-01-01

    Full Text Available Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Patients are usually treated with broad spectrum antibiotics and surgery when indicated.

  15. Recurrent Cellulitis: How Can I Prevent It?

    Science.gov (United States)

    ... M.D. To help prevent recurrent episodes of cellulitis — a bacterial infection in the deepest layer of skin — keep skin ... www.merckmanuals.com/professional/dermatologic_disorders/bacterial_skin_infections/cellulitis.html?qt=cellulitis&alt=sh. Accessed Dec. 20, ...

  16. [Cellulitis: clinical manifestations and management].

    Science.gov (United States)

    Blum, C-L; Menzinger, S; Genné, D

    2013-10-09

    Cellulitis is an acute bacterial non-necrotizing dermal-hypodermal infection predominantly affecting the lower limbs. It is characterised by a circumscribed erythema with a raised border and fever. The predisposing factors are skin wounds, edema from any cause and systemic factors (diabetes, immunosuppression). The diagnosis is clinical and the most common complication is recurrence. Other complications include local abscess, fasciitis and bacteremia. The germ is rarely identified. The majority of infections (85%) is due to group A beta-hemolytic streptococcus. The treatment of cellulitis consists of an association of an antibiotic with rest of the concerned area.

  17. Cellulitis: definition, etiology, and clinical features.

    Science.gov (United States)

    Gunderson, Craig G

    2011-12-01

    Cellulitis is a common condition seen by physicians. Over the past decade, skin and soft tissue infections from community-associated methicillin-resistant Staphylococcus aureus have become increasingly common. In this article, the definition, etiology, and clinical features of cellulitis are reviewed, and the importance of differentiating cellulitis from necrotizing soft tissue infections is emphasized. Empiric antimicrobial recommendations are suggested, including the most recent recommendations from the Infectious Disease Society of America.

  18. Cellulitis

    Science.gov (United States)

    ... system — such as diabetes, leukemia and HIV/AIDS — leave you more susceptible to infections. Certain medications, such as corticosteroids, also can weaken your immune system. Skin conditions. Skin disorders — such as eczema, athlete's ...

  19. Cellulitis

    Science.gov (United States)

    The health care provider will perform a physical exam. This may reveal: Redness, warmth, and swelling of the skin Possible drainage, if there is a buildup of pus ( abscess ) with the skin infection Swollen glands (lymph nodes) ...

  20. Cellulitis Due to Salmonella infantis.

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    Satish R Patil

    2013-01-01

    Full Text Available Bacteria of the genus Salmonella are highly adapted for the growth in both humans and animals and cause a wide spectrum of disease. The growth of Serotypes S. typhi and S. paratyphi is restricted to human hosts, in whom these organisms cause enteric (typhoid fever. The remaining Serotypes (non typhoidal Salmonella or NTS can colonize the gastrointestinal tracts of the broad range of animals, including mammals, reptiles, birds and insects. The usual clinical presentation of non-typhoidal salmonellae (NTS infection is self limited gastroenteritis; however bacteremia and focal extra intestinal infection may occur. However salmonella localization to the skin presenting as cutaneous ulceration is regarded as a rare event. Rates of morbidity and mortality associated with NTS are highest among the elderly, infants, and immunocompromised individuals, including those with hemoglobinopathies, HIV infection, or infections that cause blockade of the reticuloendothelial system. We isolated S.infantis in 50 years old man with left leg cellulitis. The serotype was confirmed at Central Research Institute, Kasauli.

  1. Mastoiditis mimicry: retro-auricular cellulitis related to otitis externa.

    Science.gov (United States)

    Block, Stan L

    2014-09-01

    Retro-auricular cellulitis associated with otitis externa is now the great mimicker of mastoiditis. It may be the most common cause of this specific cellulitis/auricular protrusion when it is associated with otitis externa. This column presents six cases of children who presented with peri-auricular redness, four of whom had protuberant ear and retro-auricular cellulitis.

  2. Diagnosis of Cellulitis in the Immunocompromised Host

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    Charles F Carey

    1990-01-01

    Full Text Available A prospective study of diagnostic techniques in cellulitis was performed on 28 patients with malignancy. Twenty-two (78% of the fine needle aspiration cultures and 10 (35% of the blood cultures were positive in this immunocompromised population. The incidence of positive fine needle aspiration cultures (P<0.005 or bacteremia (P<0.0005 was significantly higher than results obtained in an immunocompetent population with cellulitis at the same institution. Staphylococci or streptococci were recovered in 59% of positive cultures, while aerobic Gram-negative bacilli grew in 33%. This study indicates that in the immunocompromised population with cellulitis, fine needle aspiration and blood cultures should be obtained, and the antibiotic regimen should cover Gram-positive cocci and Gram-negative bacilli pending the results of cultures.

  3. Bullous leukemia cutis mimicking facial cellulitis*

    Science.gov (United States)

    Caldato, Luciana de Sales; Britto, Juliana de Sousa; Niero-Melo, Ligia; Miot, Hélio Amante

    2016-01-01

    Bullous leukemia cutis is an uncommon clinical manifestation of cutaneous infiltration by leukemic cells, from B-cell chronic lymphocytic leukemia. We present the case of a 67-year-old, female, chronic lymphocytic leukemia patient. She was taking chlorambucil and developed facial edema with erythema and warmth, misjudged as facial cellulitis. Two days later, she developed bullous lesions in the arms, legs, neck and face. The histopathology of facial and bullous lesions confirmed leukemia cutis. All lesions disappeared following the administration of rituximab combined with cycles of fludarabine and cyclophosphamide. Although soft tissue infections are common complications in patients undergoing chemotherapy, leukemia cutis can also resemble cellulitis. PMID:27192532

  4. Celulitis por citomegalovirus Cytomegalovirus cellulitis

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    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.Cutaneous lesions in CMV infection are rare, often a late manifestation of systemic infection, and usually herald a fatal course. A 70 year-old woman received a kidney transplantation one month before consulting and immunosuppressive therapy that included cyclosporine A and methylprednisone. She complained of fever, local pain in her right leg, and an erythematous and swelling plaque. She was treated with intravenous antibiotics without improvement. A skin biopsy was performed and the tissue obtained was sent for bacterial and fungal cultures as well as for histological examination. Cultures were negative. The biopsy showed CMV cytopathic changes. Immunoperoxidase staining was positive for CMV and polymerase chain reaction (PCR testing revealed CMV DNA. She was treated with ganciclovir with resolution of the lesion. CMV cellulitis is a rare cutaneous manifestation

  5. Infestazione intestinale da Schistosoma mansoni: un caso emblematico di importazione

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    Maria Chiara Medori

    2005-12-01

    Full Text Available Viene descritto, sia dal punto di vista clinico che parassitologico, un caso di importazione di schistosomiasi intestinale da S. mansoni contratta durante un soggiorno in Tanzania. Dopo circa 50 giorni da un contatto casuale ma ripetuto con le acque del Lago Vittoria, al soggetto, giovane adulto in missione umanitaria, compare febbre elevata, accompagnata da astenia (presente da più giorni cui segue un episodio di diarrea acuta. La comparsa anche di una ipereosinofilia, dapprima assente, spinge il curante ad eseguire immediatamente un esame coproparassitologico standard (in precedenza sempre negativo che risulta positivo per uova di S. mansoni. La terapia condotta con praziquantel risolve il caso e porta a guarigione il soggetto, cui inizialmente era stata esclusa la malaria, allorché dopo circa 1 mese dal rientro aveva presentato rialzo termico con disturbi respiratori.

  6. Group G Streptococcus bacteremia in recurrent cellulitis.

    Science.gov (United States)

    di Meo, Nicola; Stinco, Giuseppe; Gubertini, Nicoletta; Patriarca, Maria Martina; Trevisan, Giusto

    2014-01-01

    In recent years, group G Streptococcus has been reported with increasing frequency as the cause of a variety of human infections. Underlying host factors such as immunosuppression, malignancy, diabetes mellitus, and rheumatoid arthritis may be predisposing conditions leading to infection. Toxic involvement and post-streptococcal sequalae, once believed to be exclusive to infections caused by group A Streptococcus, are now known to occur following acute group G Streptococcus and group C Streptococcus infections. We report on a case of group G Streptococcus bacteremia and recurrent cellulitis with toxic involvement. Patient blood cultures were always negative for β-hemolytic Streptococci in all the recurrences, except during the last one. Antibiotic therapy based on antibiogram quickly resolved the infection. A regimen of intramuscular injection of 1.2 million units of benzathine penicillin every 15 days for one year prevented recurrences of cellulitis.

  7. Campylobacter jejuni cellulitis in a patient with pan-hypogammaglobulinaemia

    OpenAIRE

    Hopkins, S; Abuzakouk, M; Brannigan, E; Bergin, C; Feighery, C

    2011-01-01

    The case of a 17-year-old male with recurrent episodes of cellulitis affecting his left shin is presented. The cellulitis had been present on an intermittent basis over an 18-month period despite several courses of both intravenous and oral antibiotics. Each course of antibiotics resulted in a temporary remission, but on four occasions the cellulitis then relapsed. The patient was known to have pan-hypogammaglobulinaemia and was receiving intravenous IgG replacement therapy every 3 weeks. Oth...

  8. Il controllo epigenetico di geni oncosoppressori nelle cellule staminali neuronali normali e di medulloblastoma

    OpenAIRE

    Begalli, Federica

    2013-01-01

    Le cellule staminali cerebellari normali fanno parte della grande famiglia delle cellule staminali somatiche, deputate a sostituire le cellule che muoiono per omeostasi fisiologica del tessuto o per un danno. Tali cellule mantengono alcune delle caratteristiche versatili delle cellule staminali embrionali. In particolare sono dotate della capacità di auto-rinnovamento indefinito e di multipotenza, difatti sono in grado di differenziare in più linee cellulari. Le cellule staminali neuronali ...

  9. Métastases gastro-intestinales du cancer du sein: à propos de 2 cas

    Science.gov (United States)

    Loubna, Mezouar; Mohamed, El Hfid; Tijani, El Harroudi; Fouzia, Ghadouani; Hanane, Haj Kacem; Zouhour, Bourhaleb; Asmae, Ouabdelmoumen

    2013-01-01

    Le cancer du sein est le cancer le plus fréquent chez la femme, notamment au Maroc, avec un taux de mortalité élevé. Les métastases gastro-intestinales d'un carcinome canalaire du sein sont rares. Leur diagnostic est difficile du fait de la nature non spécifique des symptômes. Nous rapportons deux observations originales de métastases gastroduodénales d'un cancer canalaire infiltrant du sein. Les métastases gastro-intestinales du cancer du sein sont très rares; la présence de symptômes gastro-intestinaux chez une malade ayant un antécédent de cancer du sein doit faire suspecter une atteinte métastatique gastro-intestinale. PMID:24198876

  10. Cellulitis in a Red Kandhari Bull : A Case Report

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    M M Pathan

    2012-06-01

    Full Text Available A case of cellulitis caused by mixed infection of Staphylococcus spp. and Corynebacterium spp in a Red Kandhari bull leading to death of animal was autopsied at the department. It is being a case of cellulitis in a Red Kandhari bull and placed on record. [Vet. World 2012; 5(3.000: 183-184

  11. INCIDENCE AND CLINICAL FEATURES OF SNAKEBITE CELLULITIS AT KIMS, HUBLI

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    Chetan

    2014-12-01

    Full Text Available BACKGROUND: A single centre study was planned to asses the incidence and clinical feature of snake bite cellulitis in order to find out the nature and burden of the disease. OBJECTIVES: To assess incidence and clinical features of snake bite cellulitis. METHODOLOGY: This present one year prospective study was conducted in the Department of Surgery, Karnataka Institute of Medical Sciences, Hubli. Out of 520 total cases of snake bites 66 patients with cellulitis changes were studied. STATISTICAL ANALYSIS: The data obtained was coded and entered in Microsoft Excel Spreadsheet. The categorical data was expressed as rates, ratios and percentages. RESULTS: Out of 520 total snake bite cases, 66 patients developed signs of cellulitis. In patients with cellulitis 49(74.24% were males and 17(25.75% were females. In patients with cellulitis, most were aged between 31 to 45 years (36.36% and 19 to 30 years (34.84.The mean age of the study population was 32.43 ± 13.75 years. Majority of the patients (74.24% had snake bite on lower limbs. Most common symptom complex noted was pain + swelling in 30(39.39% of the patients followed by pain in 9(13.6%, swelling in 6(9%, pain+swelling+fever in 4(6%, pain + discolouration in 2(3% and pain + fever in 1(1.5% of the patients. CONCLUSIONS: The present study shows high incidence of cellulitis in patients with snake bite and most common clinical feature is cellulitis is pain + swelling. So in any case of snake of snake bite we should take the proper precautionary measures to prevent cellulitis. If cellulitis has already formed, then it should be treated without delay in order to prevent limb loss, compartment syndrome, other morbidities and even death.

  12. Cellules solaires photovoltaïques plastiques enjeux et perspectives

    Science.gov (United States)

    Sicot, L.; Dumarcher, V.; Raimond, P.; Rosilio, C.; Sentein, C.; Fiorini, C.

    2002-04-01

    Après avoir détaillé le fonctionnement d'une cellule photovoltaïque plastique et les paramètres photovoltaïques permettant de caractéiser son efficacité, un état de l'art des technologies de fabrication des cellules est présenté. Des moyens d'amélioration des performances des cellules photovoltaïques organiques sont ensuite illustrés par l'étude de dispositifs développés au Laboratoire Composants Organiques (LCO) du CEA Saclay.

  13. Orbital cellulitis following silicone-sponge scleral buckles

    OpenAIRE

    Nemet AY; Ferencz JR; Segal O; Meshi A

    2013-01-01

    Arie Y Nemet, Joseph R Ferencz, Ori Segal, Amit Meshi Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel Background: Acute or chronic infection of the scleral explant is rare. We report seven cases of scleral explant infections that caused orbital cellulitis. Materials and methods: This was a retrospective chart review of oculoplastics at oculoplastics and vitreo-retinal units in a secondary referral hospital. All subjects had orbital cellulitis secondary to scleral buckle i...

  14. Sweet's syndrome associated with cellulitis - a challenging diagnosis

    OpenAIRE

    Resende, Cristina; Santos, Rui; Pereira,Teresa; Brito,Celeste

    2016-01-01

    Abstract Sweet's syndrome is a neutrophilic dermatosis with worldwide distribution that has been associated with inflammatory autoimmune diseases, infections, malignancies, drugs, and pregnancy. The disease is idiopathic in up to 50% of patients. A 64-year-old woman, diagnosed with right limb cellulitis (4 days of evolution), was seen at our department, due to persistent cellulitis and progressive appearance of painful nodules and plaques in both shins and the right forearm (2 days of evoluti...

  15. Serratia marcescens: an unusual pathogen associated with snakebite cellulitis.

    Science.gov (United States)

    Subramani, Parimala; Narasimhamurthy, Gokul Bindiganavile; Ashokan, Bhaskaran; Madappa, Beena Prasavangada

    2013-02-15

    This study reports a case of Serratia marcescens cellulitis following a snakebite in a 50-year-old woman. The bite was on the dorsum of the right hand with symptoms of envenomation. She developed swelling and cellulitis with tissue necrosis. Wound debridement was performed.  Pus and tissue biopsy cultures yielded Serratia marcescens sensitive to fluoroquinolones, aminoglycosides, third-generation cephalosporins and carbapenems. The patient responded to anti-snake venom (ASV) therapy, ciprofloxacin, local wound management and recovered uneventfully.

  16. Bacillus cereus cellulitis from contaminated heroin.

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    Dancer, S J; McNair, D; Finn, P; Kolsto, A B

    2002-03-01

    Concern exists over recent unexplained deaths among intravenous drug users. This report describes a patient with crepitant cellulitis who was admitted complaining of severe pain in the right forearm. Ultrasonography demonstrated gas in the tissues and he was referred for early surgical debridement of the arm. He was treated with intravenous benzyl penicillin, gentamicin and metronidazole and made a full recovery. Aspirate samples grew Bacillus cereus, morphologically similar to the isolate obtained from a sample of the patient's own heroin. Antibiogram and API 50CHB profiles were also similar. Further typing included 'H' flagellar serotyping, which found both blood and heroin strains to be non-typable, and amplified fragment polymorphism analysis, which showed that the strains were indistinguishable. Genotyping of two selected genes from B. cereus confirmed almost certain identity between the two strains. This case illustrates the potential virulence of B. cereus when inoculated into tissues, and to our knowledge, is the first report to demonstrate a conclusive microbiological link between contaminated heroin and serious sepsis in a drug user due to B. cereus.

  17. Ambient Ozone and Emergency Department Visits for Cellulitis

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    Mieczysław Szyszkowicz

    2010-11-01

    Full Text Available Objectives were to assess and estimate an association between exposure to ground-level ozone and emergency department (ED visits for cellulitis. All ED visits for cellulitis in Edmonton, Canada, in the period April 1992–March 2002 (N = 69,547 were examined. Case-crossover design was applied to estimate odds ratio (OR, and 95% confidence interval per one interquartile range (IQR increase in ozone concentration (IQR = 14.0 ppb. Delay of ED visit relating to exposure was probed using 0- to 5-day exposure lags. For all patients in the all months (January–December and lags 0 to 2 days, OR = 1.05 (1.02, 1.07. For male patients during the cold months (October-March: OR = 1.05 (1.02, 1.09 for lags 0 and 2 and OR = 1.06 (1.02, 1.10 for lag 3. For female patients in the warm months (April-September: OR = 1.12 (1.06, 1.18 for lags 1 and 2. Cellulitis developing on uncovered (more exposed skin was analyzed separately, observed effects being stronger. Cellulitis may be associated with exposure to ambient ground level ozone; the exposure may facilitate cellulitis infection and aggravate acute symptoms.

  18. Caratteristiche biologiche e potenziale applicativo delle cellule staminali derivate da membrane fetali

    OpenAIRE

    Costa, Roberta

    2013-01-01

    La ricerca sulle cellule staminali apre nuove prospettive per approcci di terapia cellulare. Molta attenzione è concentrata sulle cellule staminali isolate da membrane fetali, per la facilità di recupero del materiale di partenza, le limitate implicazioni etiche e le caratteristiche delle popolazioni di cellule staminali residenti. In particolare a livello dell’epitelio amniotico si concentra una popolazione di cellule (hAECs) con interessanti caratteristiche di staminalità, pluripotenza e im...

  19. Is it necrotizing fasciitis or necrotizing cellulitis after varicella zoster infection? Two case reports.

    Science.gov (United States)

    Gundeslioglu, Ayse Ozlem; Selimoglu, Muhammed Nebil; Toy, Hatice

    2014-08-01

    Necrotizing fasciitis and necrotizing cellulitis are serious cutaneous complications in varicella patients. Differentiation of necrotizing cellulitis from necrotizing fasciitis can initially be challenging because of indistinct clinical course at the onset of infection and the lack of definitive diagnostic criteria. This paper reports 2 children with necrotizing cellulitis that developed after varicella infection to draw the attention of health care providers to necrotizing cellulitis that showed slower clinical course than necrotizing fasciitis and recovered with conservative treatment approaches without aggressive surgical intervention.

  20. Risk factors of cellulitis in cirrhosis and antibiotic prophylaxis in preventing recurrence

    OpenAIRE

    Hamza, Rooby Erachamveettil; Villyoth, Mashhood Padincharepurathu; Peter, George; Joseph, Deni; Govindaraju, Chethan; Tank, Devang Chandrakanth; Sreesh, Sreejaya; Narayanan, Premalatha; Vinayakumar, Kattoor Ramakrishnan

    2014-01-01

    Background Cellulitis is a commonly encountered bacterial infection among cirrhotic patients apart from spontaneous bacterial peritonitis, urinary tract and respiratory infections. This study aimed to determine the risk factors of cellulitis in cirrhosis and whether antibiotic prophylaxis helps prevent recurrence of cellulitis. Methods The study was conducted in two phases. In phase 1, all cirrhotic patients admitted with cellulitis from August 2011 to August 2013 were taken as cases (n=70) a...

  1. Retropharyngeal cellulitis complicated by cervical spondylodiscitis: A case report

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    Gülşen İskender

    2015-12-01

    Full Text Available Secondary to pharyngeal trauma such as endotracheal intubation, endoscopy and after foreign body ingestion, or removal may develop retropharyngeal cellulitis in adults. These infections occur mainly in children between 1 to 8 years of age with 75% of cases occurring before the age of 5 years. Retropharyngeal cellulitis is a serious deep space infection which can extend from neck to the mediastinum.Herein, we represent a case of 24-year-old female patient who presented with neck pain, odynophagia, and malaise two months after accidental ingestion of a little pin. Uncomplicated removal of this pin was followed by development of retropharyngeal cellulitis and cervical pondylodiscitis. The patient was successfully treated with intravenous and oral antibiotics for 12 weeks without need to surgical intervention.We believe that early and aggressive medical treatment can eradicate nonsuppurative complicated retropharyngeal infection without the need for surgery. J Microbiol Infect Dis 2015;5(4: 180-183

  2. Nonpigmented Chromobacterium violaceum bacteremic cellulitis after fish bite.

    Science.gov (United States)

    Yang, Ching-Huei

    2011-10-01

    A case of nonpigmented Chromobacterium violaceum bacteremic cellulitis after fish bite in Taiwan is reported. The patient was successfully treated with ciprofloxacin and doxycycline for an extended period. Chromobacterium violaceum should be listed in the differential diagnosis of patients with nonspecific cellulitis associated with marked leukocytosis and rapid progression to septicemia either with or without a distinct history of exposure to water or soil. A combination of prompt diagnosis, optimal antimicrobial therapy, and adequate therapeutic duration for C violaceum infection is the key for successful therapy.

  3. Rol de galectina-1 en la fisiopatología de las Enfermedades Inflamatorias Intestinales

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    Papa Gobbi, Rodrigo

    2015-01-01

    Las Enfermedades Inflamatorias Intestinales (EII) son un conjunto de patologías crónicas multifactoriales en las cuales se produce una respuesta inmune aberrante contra componentes de la microbiota intestinal. Dentro de las EII, la colitis ulcerosa (CU) y la enfermedad de Crohn (EC) son las dos formas más estudiadas. Si bien existen diferencias en la presentación clínica de estas patologías, en ambos casos los linfocitos T (LT) de la mucosa sobre-expresan citoquinas pro-inflamatorias del perf...

  4. Genetic susceptibility to non-necrotizing erysipelas/cellulitis.

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    Katariina Hannula-Jouppi

    Full Text Available BACKGROUND: Bacterial non-necrotizing erysipelas and cellulitis are often recurring, diffusely spreading infections of the skin and subcutaneous tissues caused most commonly by streptococci. Host genetic factors influence infection susceptibility but no extensive studies on the genetic determinants of human erysipelas exist. METHODS: We performed genome-wide linkage with the 10,000 variant Human Mapping Array (HMA10K array on 52 Finnish families with multiple erysipelas cases followed by microsatellite fine mapping of suggestive linkage peaks. A scan with the HMA250K array was subsequently performed with a subset of cases and controls. RESULTS: Significant linkage was found at 9q34 (nonparametric multipoint linkage score (NPL(all 3.84, p=0.026, which is syntenic to a quantitative trait locus for susceptibility to group A streptococci infections on chromosome 2 in mouse. Sequencing of candidate genes in the 9q34 region did not conclusively associate any to erysipelas/cellulitis susceptibility. Suggestive linkage (NPL(all>3.0 was found at three loci: 3q22-24, 21q22, and 22q13. A subsequent denser genome scan with the HMA250K array supported the 3q22 locus, in which several SNPs in the promoter of AGTR1 (Angiotensin II receptor type I suggestively associated with erysipelas/cellulitis susceptibility. CONCLUSIONS: Specific host genetic factors may cause erysipelas/cellulitis susceptibility in humans.

  5. Serum Procalcitonin Level Reflects the Severity of Cellulitis

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    Noh, Soo Hyeon; Park, Seok Don

    2016-01-01

    Background Cellulitis is a common bacterial infection of the superficial skin. Procalcitonin is one of the precursor proteins of calcitonin, its levels are elevated in bacterial infection, and it has been established as a diagnostic marker for severe bacterial infections. Objective This study evaluated the clinical usefulness of procalcitonin for predicting disease severity and prognosis of cellulitis. Methods We reviewed the medical records of 160 patients diagnosed with cellulitis in the past 3 years. Body temperature, procalcitonin, white blood cell (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured on their first day of admission. The associations of procalcitonin, WBC, ESR, and CRP with the body temperature and the number of hospitalized days were assessed. Results Procalcitonin, WBC, and CRP showed a positive correlation with body temperature. In addition, procalcitonin, WBC, ESR, and CRP showed a positive correlation with number of hospitalized days (p<0.05). Conclusion In patients diagnosed with cellulitis, proclacitonin was a helpful parameter to indicate the severity of disease and also a useful predictor of prognosis. PMID:27904269

  6. Clinical Approach in Orbital Cellulitis Cases: Case Series

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    Altan Atakan Özcan

    2012-07-01

    Full Text Available Pur po se: To evaluate the etiological factors, diagnosis, follow-up and treatment procedures in cases of orbital cellulitis. Ma te ri al and Met hod: A retrospective review was performed on medical records of patients with orbital cellulitis treated between 2009 and 2011 in our clinic. The patients were studied for age, ophthalmologic examination features, laboratory and radiology results, treatment modalities and the response to these treatments. Re sults: Eleven patients (7 male, 4 female having an average age of 9.7 years (6 months-25 years participated in the study. All patients had eyelid oedema, hyperemia and ocular pain; with chemosis in 3, gaze restriction in 6, relative afferent pupillary defect and proptosis in 4 cases. Orbital cellulitis was observed to occur secondary to paranasal sinusitis in 10 patients (90.9% and 1 patient had only history of superior respiratory tract infection. Sinus infection was localized in ethmoid and maxillary sinuses in all except one case. Laboratory tests showed leukocytosis in 8 patients. Surgical drainage was performed in 7 of 8 patients with abscess formation observed with radiological imaging. The remainder of the patients were followed with sole medical treatment. All patients recovered without any vision loss or life-threatening complication. Dis cus si on: Orbital cellulitis cases must be followed with radiologic imaging for any complication that may occur and patients with abscess should be evaluated for surgical drainage besides antimicrobial treatment.(Turk J Ophthalmol 2012; 42: 284-7

  7. Orbital cellulitis following silicone-sponge scleral buckles

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    Nemet AY

    2013-10-01

    Full Text Available Arie Y Nemet, Joseph R Ferencz, Ori Segal, Amit Meshi Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel Background: Acute or chronic infection of the scleral explant is rare. We report seven cases of scleral explant infections that caused orbital cellulitis. Materials and methods: This was a retrospective chart review of oculoplastics at oculoplastics and vitreo-retinal units in a secondary referral hospital. All subjects had orbital cellulitis secondary to scleral buckle in the range of January 1990 to March 2010. Demographics, imaging studies, and pathology specimens were reviewed. Results: A total of 841 silicone-sponge scleral buckle implants for rhegmatogenous retinal detachment were performed. Forty were extracted (4.75%; annual rate of 1.9 cases. Seven (0.83% had orbital cellulitis. The mean time from implantation to presentation was 5.7 years. There was bacterial growth in all specimens, with Staphylococcus aureus in four. Conclusions: Patients who are operated on with silicone-sponge scleral buckling for rhegmatogenous retinal detachment sometimes require removal of the implant because of infection. However, the infection rate is low. Patients should be followed in the long term for possible complications. Keywords: scleral explant infection, scleral buckle, orbital cellulitis, rhegmatogenous retinal detachment

  8. Achromobacter xylosoxidans Bacteremia and Cellulitis: A Report of a Case.

    Science.gov (United States)

    Dai, Julia; Huen, Auris O; Kestenbaum, Lori A; Sarezky, Margaret D; Coughlin, Carrie C; Yan, Albert C

    2015-01-01

    Achromobacter xylosoxidans is a rare, opportunistic infection most commonly encountered in immunocompromised patients during hospitalization. Primary uncomplicated bacteremia, catheter-associated infections, and pneumonia have been reported as the most common clinical presentations; skin and soft tissue infections from A. xylosoxidans are rare. We describe a case of A. xylosoxidans presenting as cellulitis and bacteremia in an immunocompromised patient.

  9. Orbital cellulitis in a neonate of the tooth bud origin : A case report

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    Poonam Lavaju

    2014-01-01

    Full Text Available Orbital cellulitis is a serious, yet uncommon infection in neonates. It can result in significant sight and life threatening complications. Most commonly, it occurs secondarily as the result of a spread of infection from the sinuses. Orbital cellulitis, secondary to dental infection is rare. We hereby report a case of orbital cellulitis secondary to dental infection in a 15-day-old neonate without any systemic features.

  10. Pneumococcal sepsis, peritonitis, and cellulitis at the first episode of nephrotic syndrome.

    Science.gov (United States)

    Naseri, Mitra

    2013-09-01

    Bacterial infections are common in patients with nephrotic syndrome, including peritonitis, sepsis, meningitis, urinary tract infection, and cellulitis. An 8-year-old boy presented with colicky abdominal pain, vomiting, swollen and painful erythematous lesions around the umbilicus and in anterior surface of left thigh (cellulitis), mild generalized edema, and ascites. The microorganism isolated from peritoneal fluid and blood cultures was Pneumococcus. Association of pneumococcal sepsis, peritonitis, and cellulitis has been rarely reported in nephrotic syndrome.

  11. Prevalencia de parasitosis intestinales en unidades educativas de Ciudad Bolívar, Venezuela

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    José Antonio Nastasi Miranda

    2015-07-01

    Full Text Available Introducción: Las parasitosis intestinales a nivel mundial son un problema de salud pública que afecta a los países en las zonas tropicales. Un grupo muy vulnerable a padecer este tipo de infección son los niños. El objetivo de la presente investigación fue determinar la prevalencia general de parásitos intestinales en las Unidades Educativas de Ciudad Bolívar, entre los años 2009 - 2013. Materiales y Métodos: Fueron obtenidos los trabajos de grado sobre el tema del Departamento de Parasitología y Microbiología y así se recolectaron datos sobre edad, sexo, tipo de parasito, especies y asociaciones parasitarias y poder calcular así dicha prevalencia general. Resultados: Se encontró una prevalencia general de 63,1% sin predilección por la edad o sexo. Los tipos de parásitos más prevalentes fueron los protozoarios con 83,5%. Las especies más prevalentes fueron Blastocystis spp con 39,7%, Entamoeba coli con 15,3%, y Giardia intestinalis con 13,4%. Las asociaciones parasitarias más frecuentes Blastocystis spp con Endolimax nana (21,1% y Blastocystis spp con Entamoeba coli. (7,4%. Discusión: Los resultados de este estudio guardan relación con estudios realizados a nivel nacional como internacional, con respecto a las prevalencias de parasitosis, el predominio de protozoarios sobre helmintos en los últimos años, y la indistinción de la infección parasitaria con respecto al género. Conclusiones: La prevalencia aquí estudiada a manera general es alta, se recomienda seguir haciendo este tipo de estudios en escuelas para denotar el impacto de estas infecciones en niños y la consecuencia que esto conlleva.  Cómo citar este artículo: Nastasi JA. Prevalencia de parasitosis intestinales en unidades educativas de Ciudad Bolívar, Venezuela. Rev Cuid. 2015; 6(2:1077-84. http://dx.doi.org/10.15649/cuidarte.v6i2.181

  12. Implication de la flore intestinale dans le métabolisme énergétique

    OpenAIRE

    Delzenne, Nathalie M; Cani, Patrice D.

    2008-01-01

    La flore intestinale est aujourd’hui considérée comme un organe à part entière, qui joue un rôle clé dans le métabolisme énergétique. La flore peut en effet augmenter la rentabilité énergétique des aliments ingérés qui ont échappé à la digestion dans la partie haute de l’intestin, via leur fermentation. Par ailleurs, le flux des acides gras et leur stockage adipocytaire sont contrôlés - notamment via le facteur FIAF (fastinginduced adipocyte factor), dont l’expression est tributaire de la pré...

  13. Encuesta de parásitos intestinales en 615 escolares del Rímac

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    Luis Gonzales-Mugaburu

    1956-12-01

    Full Text Available El examen microscópico de una sola muestra de heces de cada uno de 615 escolares del Rímac, ha mostrado: 1. El elevado porcentaje de protozoarios intestinales encontrados, sugiere una alta contaminación fecal. 2. La alta frecuencia de H. nana 166 (27.0% constituye un problema al que hay que prestar atención. 3. El hallazgo de Strongyloides stercoralis y Ancylostoma o Necator sólo en sujetos que habían estado algún tiempo en la Selva del Perú, sugiere una vez más, que dichos parásitos no son transmitidos en esta parte de la Costa. 4. La presencia de tres casos de Isospora belli nos indica que esta coccidia es más frecuente de lo que se suponía.

  14. Detección de parásitos intestinales en agua y alimentos de Trujillo, Perú

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    Gregorio Pérez-Cordón

    2008-01-01

    Full Text Available Detectamos distintas especies de parásitos intestinales, tanto protozoos como helmintos, presentes en muestras de agua provenientes de acequias y pozos (Giardia lamblia, Blastocystis hominis, Entamoeba coli, Cyclospora cayetanensis, Cryptosporidium spp. y Balantidium coli, así como en alimentos crudos y cocidos (Giardia lamblia, Cyclospora cayetanensis., Endolimax nana, Iodamoeba butschlii y Blastocystis hominis Fasciola hepatica y Ascaris lumbricoides recolectadas en varios distritos de la provincia de Trujillo, Perú.

  15. Parasitosis intestinales en relación con la cultura higiénica de poblaciones rurales de Catamarca.

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    Monferrán, M. C.

    2003-01-01

    Full Text Available Los estudios realizados sobre prevalencia de parasitosis intestinales humanas en comunidades urbanas y rurales en la provincia de Catamarca, revela altos índices. Las causas son múltiples, entre las que se encuentran factores ecológicos y sociales. Las condiciones climáticas imperantes en una zona geográfica resultaran favorables o no a la presentación de algunas parasitosis como por ejemplo las geohelmintiasis.Se atribuye igual importancia a la educación, vivienda, alimentación, recursos económicos, falta de higiene, contaminación ambiental, etc.. Se realizan estudios de prevalencia de parasitosis intestinales en pobladores de dos regiones climáticamente diferentes de nuestra provincia como son los Dptos. La Paz y Paclín detectándose en algunas comunidades índices altos de hasta el 81 %.También se ha notado la influencia climática regional sobre la distribución de las parasitosis intestinales .En La Paz, existe un predominio de las protozoosis y en Paclín las geohelmintiasis son frecuentes y diversas. Las parasitosis detectadas estarían relacionadas en un alto grado a la denominada cultura higiénica, pues las prácticas de la higiene individual y familiar, la deposición de sus excretas, la convivencia con animales domésticos, el manejo de sus rebaños, son costumbres regionales que se han transmitido por generaciones e influyen notablemente en la difusión y la conservación de estos altos índices de parasitosis intestinales en detrimento de la salud de los habitantes.

  16. Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment.

    Science.gov (United States)

    Devrim, Ilker; Kanra, Güler; Kara, Ateş; Cengiz, A Bülent; Orhan, Mehmet; Ceyhan, Mehmet; Seçmeer, Gülten

    2008-01-01

    The infection of the orbita and ocular tissues can result in severe local and systemic complications. We aimed to determine the predisposing factors for preseptal and orbital cellulitis, the clinical and routine laboratory differences between orbital and preseptal cellulitis, and the change in the spectrum of the pathogens and the antibiotics used in the last 10 years. One hundred thirty-nine patients, hospitalized in Hacettepe University Faculty of Medicine Children's Hospital between 1 January 1990 and 31 December 2003 with diagnosis ofperiorbital or orbital cellulitis, were reviewed retrospectively. Ten of the patients (7%) had orbital and 129 (93%) had preseptal cellulitis. The male/female ratio was 1.7:1. The average age (mean+/-standard deviation) was 5.7+/-4 years. The seasonal distribution was most marked in spring and fall periods. When compared with preseptal cellulitis, the mean blood cell count, erythrocyte sedimentation rate and C-reactive protein levels were significantly higher in patients with orbital cellulitis. Staphylococcus aureus was isolated in 13 (41.9% of total microbiologically confirmed cases), coagulase-negative staphylococcus in 8 (25.8%), and H. influenza type b in 2 patients (6%). Thirty out of 77 clinical sample cultures (39%) were positive. In clinical studies, etiological agents of orbital and preseptal cellulitis could be identified in only 20-30% of cases, so in clinical practice treatment is usually empiric. We observed that sulbactam-ampicillin was a safe and effective choice of treatment in orbital and preseptal cellulitis in our cases.

  17. Antimicrobial resistance of bacterial strains isolated from avian cellulitis

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    MM Santos

    2014-03-01

    Full Text Available Avian cellulitis is an inflammatory process in the subcutaneous tissue, mainly located in the abdomen and thighs. This problem is commonly observed in poultry at slaughter and it is considered one of the major causes of condemnation of carcasses in Brazil. The aim of this study was to perform the microbial isolation of lesions of avian cellulitis from a processing plant located in the State of Goiás in order to analyze antimicrobial resistance by antibiogram test and to detect resistance genes by polymerase chain reaction. A total of 25 samples of avian cellulitis lesions were analyzed, from which 30 bacterial strains were isolated. There were eleven (44% strains of Escherichia coli, nine (36% strains of Staphylococcus epidermidis, seven (28% strains of Proteus mirabilis and three (12% strains of Manheimiahaemolytica. The antibiogram test showed that all strains were resistant to at least one antimicrobial. The gene of antimicrobial resistance tetB was detected in E. coli, S. epidermidis and P. mirabilis strains, and was the most frequently observed gene. The gene of antimicrobial resistance Sul1 was detected in all bacterial species, while tetA was found in E. coli and S. epidermidis strains, SHV in E. coli strains, S. epidermidis and P. mirabilis,and cat1 in one P. mirabilis strain. The results suggest a potential public health hazard due to the ability of these microorganisms to transmit antimicrobial resistancegenes to other microorganisms present in the intestinal tract of humans and animals, which may affect clinical-medical usage of these drugs.

  18. Clinical and microbiologic features of dacryocystitis-related orbital cellulitis.

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    Wladis, Edward J; Shinder, Roman; LeFebvre, Daniel R; Sokol, Jason A; Boyce, Michelle

    2016-10-01

    Dacryocystitis-related orbital cellulitis is a relatively rare condition, and large case series of this clinical entity have been reported. This study was undertaken to identify a larger cohort of patients with this ailment, with the intent of defining its clinical and microbiologic features. Case logs from four institutions were reviewed to identify patients that suffered from dacryocystitis-related orbital cellulitis. A retrospective chart review was then performed to identify clinical features, management strategies, microbiologic features, and outcomes. A dedicated statistical software package was utilized to identify correlations between these variables. 13 patients (7 females, 6 males; mean age = 57.2 years, range = 7-89 years) were identified. One patient carried a diagnosis of immunosuppressive disease. All patients underwent emergent surgical drainage and received intravenous antibiotics. Primary acquired nasolacrimal duct obstruction was found to be the underlying etiology in nine cases (69.2%), whereas four patients suffered from specific causes of their obstructions. An average of 1.07 organisms/patient (standard deviation = 0.49 organisms/patient) were recovered from microbiologic cultures, and Gram-positive bacteria represented the majority of cultured organisms. All patients experienced either stable or improved vision upon discharge. The relationships between a specific etiology and the possibility of vision loss or the number of organisms cultured, between the number of organisms cultured and vision loss, and immunosuppression and vision loss or the number of organisms cultured were all not statistically significant (p > 0.05). Dacryocystitis-related orbital cellulitis most commonly occurs in adult patients who do not carry immunosuppressive diagnoses and suffer from primary obstructions. Multiple microbiologic species may cause this problem, although Gram-positive organisms are most common. With appropriate management, stable or improved vision

  19. Complete Vision Loss following Orbital Cellulitis Secondary to Acute Dacryocystitis

    Science.gov (United States)

    Pfeiffer, Margaret L.; Hacopian, Alexander; Merritt, Helen

    2016-01-01

    We present a case of a 50-year-old woman with acute dacryocystitis that was complicated by posterior rupture of the lacrimal sac causing an orbital cellulitis with subsequent visual acuity of no light perception. Upon presentation, she was immediately started on broad-spectrum antibiotics and underwent surgical incision and drainage of the lacrimal sac abscess but never regained vision. There are 4 cases in the literature of permanent severe vision loss from acute dacryocystitis. Prompt diagnosis and close monitoring of acute dacryocystitis are therefore essential to prevent extension into the orbit and possible optic nerve compromise.

  20. Distribución espacial de las parasitosis intestinales en la ciudad de La Plata, Argentina

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    María I Gamboa

    2014-10-01

    Full Text Available El análisis de las parasitosis a diferentes escalas (regional, local se facilita por el Geographic Information System (GIS, que permite identificar áreas con distinto grado de vulnerabilidad. El objetivo del trabajo fue analizar la distribución espacial de las parasitosis intestinales en el partido de La Plata, estableciendo su relación con las condiciones socio-ambientales para identificar áreas con diferente riesgo epidemiológico. Se completó una encuesta epidemiológica y se tomaron muestras seriadas de materia fecal, analizadas por la técnica de Ritchie. Se calcularon niveles de precariedad y vulnerabilidad (Iv, y se compararon con los resultados parasitológicos. Se analizaron parasitológica y ambientalmente 653 personas, de las cuales 585 (89.6% eran niños y 68 (10.4% adultos. El análisis indicó que los más vulnerables (Iv = 3-4 estaban en el sector con menor acceso a servicios de infraestructura urbana. El índice se encontró fuertemente asociado a la prevalencia total de parasitosis intestinales y a las 4 especies patógenas asociadas a la contaminación fecal del ambiente: Trichuris trichiura, Ascaris lumbricoides, Hymenolepis nana y Giardia lamblia (p < 0.01. Enterobius vermicularis, parásito no vinculado a la condición sanitaria de sus hospedadores, no se asoció al Iv. Hubo asociación estadística entre precariedad y parasitosis y se halló que a mayor Iv mayor frecuencia de parasitosis (p < 0.01. El uso de GIS permitió zonificar las variables socioambientales en un gradiente creciente de condiciones desfavorables y su relación con la presencia de especies patógenas. La continuidad de estos estudios en diferentes regiones de Argentina contribuye a la determinación de áreas en riesgo sanitario.

  1. Orbital Cellulitis: A Rare Presentation of Metastatic Bronchial Carcinoma

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    Rohit Kumar

    2011-01-01

    Full Text Available Objective. We report a rare and unusual case of bronchial carcinoma presenting with symptoms of complications of sinonasal disease. Case Report. A 66-year-old lady was referred with a 1-week history of progressive ocular pain, chemosis, and visual disturbance. Computed tomography of the paranasal sinuses revealed frontal and ethmoidal sinus opacification with orbital involvement consistent with a diagnosis of orbital cellulitis secondary to sinusitis. Surgical exploration revealed that the sinuses and right orbit were filled with soft tissue and subsequent histopathological examination of the biopsies indicating metastases from an adenosquamous bronchial carcinoma. Further imaging revealed a large, asymptomatic, bronchial primary with deposits in the brain and liver. The advanced presentation of the disease limited treatment to best supportive care. Conclusion. Orbital cellulitis and sinonasal malignancies have a similar pattern of clinical presentation, posing a potential diagnostic pitfall. There are only two previously reported cases of metastatic lung carcinoma in the frontal sinus with 15 cases of sinonasal tract involvement reported overall. There are no reported cases of adenosquamous carcinoma in the sinonasal tract.

  2. Primary skeletal muscle lymphoma presenting as refractory cellulitis.

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    Baddour, L M; Haden, K H; Allen, J W

    2001-09-01

    The right torso of a 55-year-old woman showed diffuse skin and soft-tissue changes suggestive of cellulitis. However, several clinical and radiologic features, including the subacute and non-toxic nature of the illness and the patient's lack of response to antibiotic therapy, indicated a noninfectious etiology. Malignancy was suggested by striking changes seen on computed tomographic scanning--including extensive infiltration and enlargement of the musculature of the right shoulder girdle, the intercostal musculature, the latissimus dorsi, and the rhomboids; focal enlargement of the right paraspinal muscles; and enlargement of the psoas and the iliacus muscles and of the musculature around the hip joint. The mediastinal, hilar, and paraaortic regions showed no adenopathy. A large hypodense lesion of approximately 4.5 cm, which was seen in the caudate lobe of the liver, raised the concern of a metastatic focus of malignancy. Because of these findings, an immediate muscle biopsy was performed. Results showed a non-Hodgkin's lymphoma with a B-cell phenotype. Although primary skeletal muscle lymphoma is very uncommon in patients without human immunodeficiency virus infection, clinical presentation of refractory cellulitis, as seen in the current case, is extremely rare.

  3. Intestinal parasitic infections, cysticercosis and hydatic diseases Parasitosis intestinales, cisticercosis e hidatidosis

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    David Botero

    1990-03-01

    Full Text Available

    This paper offers an up to date review of the intestinal parasitic infections, cysticercosis and hydatic disease found In Colombia. Their main epidemiological, clinical, preventive and therapeutic features are presented, to provide the reader with a current view of their public health Importance, prevalence and impact on morbidity and mortality.

    Se presenta una revisión actualizada sobre las parasitosis intestinales, la cisticercosis y la hidatidosis en Colombia, con una breve descripción de la prevalencia, las características epidemiológicas, los efectos sobre la salud y algunos aspectos de control y tratamiento. Con esta revisión se busca tener información resumida sobre las parasitosis que se encuentran en Colombia y su mayor o menor Importancia en salud pública. TambIén se pretende ofrecer una Idea del nivel de gravedad de estas entidades como causas de morbilidad y mortalidad en este país. 

  4. El sentido de las enfermedades por parásitos intestinales en poblaciones americanas, identificando dilemas bioéticos

    Directory of Open Access Journals (Sweden)

    María del Pilar Díaz Murillo

    2013-01-01

    Full Text Available Objetivo: Identificar sentidos que pueblos del continente americano le asignan a las parasitosis intestinales y plantear posibles conflictos o dilemas en las tomas de decisiones en diferentes actividades de salud producto del encuentro de valores distintos, campo de acción de la bioética. Metodología: Revisión bibliográfica de artículos sobre parasitosis intestinales que cumplieran los criterios de inclusión establecidos y suministraran aportes para la comprensión hermenéutica de las parasitosis intestinales y permitieran identificar dilemas bioéticos para actividades en salud resultantes del contacto entre las visiones émica y ética (de la biomedicina. Resultados: La construcción social de las parasitosis intestinales influye en su percepción de causalidad, nocividad y como problema de salud, lo cual afecta las acciones que la gente emprenda ante ellas. Se advierte que tales construcciones sociales pueden no coincidir con la perspectiva biomédica. Se observó que en algunas poblaciones la construcción social del cuerpo se relaciona con la percepción de efectos benéficos de los parásitos. La gente reconoce factores de riesgo pero esto no necesariamente conduce a comportamientos preventivos. Algunos estudios reconocen que la educación ha sido de tipo informativo, sin participación comunitaria, lo cual impide que la gente se identifique con ella y se sienta motivada a transformar su realidad. Se identificaron diversos dilemas bioéticos producto del contacto entre visiones de las poblaciones, y la biomedicina. Conclusiones: La aproximación émica permite entender la lógica de la población sobre las parasitosis intestinales e identificar disyuntivas bioéticas. Aunque la gente reconozca los riesgos de infección, la falta de comprensión de la perspectiva émica de los parasitismos por parte del personal de salud y las deficientes condiciones de vida permiten que no se produzcan transformaciones que incidan en la disminuci

  5. Frecuencia de parásitos intestinales en expendedores de alimentos ubicados en los recintos de la UNAN-León

    OpenAIRE

    Cortés Selva, Diana Margarita; Estrada Leytón, Martha Raquel; Areas Barrera, Karla Yessenia; Téllez Sierra, Aleyda

    2008-01-01

    Se realizó un estudio de corte transversal en expendedores de alimentos ubicados en los recintos de la UNAN-León para determinar la frecuencia de parásitos intestinales. Durante los meses de Mayo a Julio se estudiaron un total de 40 individuos a cada uno se le tomó una muestra fecal y se le realizó una encuesta para medir el grado de conocimiento sobre los mecanismos de transmisión de parásitos intestinales. Las muestras fueron analizadas en el laboratorio del departamento de Microbiología y ...

  6. Association synchrone d'un cancer du sein bilatéral et d'une tumeur stromale gastro-intestinale: à propos d'un rare cas

    OpenAIRE

    Afif, Mohammed; Ouziane, Imane; Kouhen, Fadila; Khalil, Jihane; Elomrani, Fedwa; Elkacemi, Hanan; Kebdani, Tayeb; Errihani, Hassan; Benjaafar, Noureddine

    2015-01-01

    Les tumeurs stromales gastro-intestinales sont les tumeurs mésenchymateuses les plus fréquentes, pourtant, leur association avec les tumeurs du sein sont rares, seulement quelques cas cliniques sont rapportés dans la littérature. Nous rapportons l'observation d'une jeune femme de 41 ans, suivie à l'institut national d'oncologie de Rabat, pour un carcinome canalaire du sein, bilatéral, chez qui le bilan d'extension a objectivé une tumeur stromale de type gastro-intestinale aux dépens de l'esto...

  7. Prospective study on sociodynamics of cellulitis in general surgical unit

    Directory of Open Access Journals (Sweden)

    Didde Sundara Chakravarthy

    2015-05-01

    Results: The median age of the participants was 62.5 years. The following risk factors were strongly and independently associated with cellulitis and outcome of the patient; illiteracy (OR, 4; P value 0.010, age above 50 years (OR, 0.110; P value 0.000, residing in rural areas (OR, 4.008; P value 0.006, low socioeconomic status (OR, 0.241; P value 0.030 and associated co-morbid conditions (OR, 0.390; P value, 0.032. Conclusion: Patients usually presented in the late stage of disease because of illiteracy, ignorance and poor knowledge. Patients should be educated to routinely inspect their feet, and the importance of appropriate footwear should be emphasized. Patients who are actively involved in their care can improve their quality of life and have a better outcome. [Int J Res Med Sci 2015; 3(5.000: 1052-1055

  8. Chemical Cellulitis due to Peanut Oil Administration. A Case Report

    Directory of Open Access Journals (Sweden)

    Julio César Turiño Muro

    2014-03-01

    Full Text Available Chemical cellulitis is the reaction of the integuments in response to the administration of toxic substances, leading to an acute inflammatory reaction that develops into an abscess or necrosis. This disease is not frequently treated in the Department of Orthopedics and Traumatology of the Joaquin Albarrán Clinical-Surgical Hospital. We present the case of a patient who attended our institution because of increased volume in both upper limbs at the biceps and triceps areas, and marked skin necrosis accompanied by lesions of axillary adenopathy, one as an abscess. Antibiotics were prescribed prior to the completion of cultures, antibiogram and dressing under anesthesia, at present the lesions are in the healing phase.

  9. Factores causales en las complicaciones de estomas intestinales en cirugía de emergencia. Hospital Luis Vernaza, 2013.

    OpenAIRE

    Morán Mancero, María Cristina

    2014-01-01

    El estoma intestinal es una apertura del intestino en la superficie del abdomen. Las estadísticas según diversos autores indica que hay aproximadamente unas 32.000 personas ostomizadas, de las cuales el 75% presentan una colostomía y el 10% una ileostomía. Objetivo:Determinar los factores causales en las complicaciones tempranas y tardías de los estomas intestinales en la cirugía de emergencia.Metodología:Estudio de tipo Retrospectivo, Observacional, Transversal, de nivel Descriptivo y diseño...

  10. Experiencias de estudiantes voluntarios en PROCOPIN (Programa de Control de las Parasitosis Intestinales y Nutrición)

    OpenAIRE

    E. Muñoz; Molina Blanco, C.; Malmoria, A.; Mena, J.; Ciarmela, María Laura; Molina, Nora Beatriz; Pezzani, Betina Cecilia; Minvielle, Marta Cecilia

    2010-01-01

    En Argentina, la frecuencia de parasitosis intestinales en asentamientos precarios varía entre 60–70%. Los parásitos producen anemia, desnutrición proteica-energética y diarreas graves, entre otras. Estas patologías suelen ser de evolución crónica, y van deteriorando lentamente al individuo parasitado, de tal manera que no percibe la afectación de su organismo hasta que se llega a un estado irreversible. Como estudiantes voluntarios integrantes de PROCOPIN, este proyecto nos forma y nos entre...

  11. Parasitosis intestinales en Argentina: Principales agentes causales encontrados en la población y/o en el ambiente

    OpenAIRE

    Juarez, Maria Mercedes; Rajal, Verónica Beatriz

    2015-01-01

    Las parasitosis intestinales se encuentran ampliamente distribuidas en el mundo, con mayor prevalencia en los países en desarrollo. Principalmente afectan a los niños en los que además provocan disminución del desarrollo físico y mental; situación que puede potenciarse enormemente cuando se suma a un estado nutricional deficiente. La Organización Mundial de la Salud las considera una de las principales causas de morbilidad, estrechamente ligada a la pobreza y relacionada con inadecuada higien...

  12. Toxic scarlet fever complicating cellulitis: early clinical diagnosis is crucial to prevent a fatal outcome.

    Science.gov (United States)

    Lau, S K; Woo, P C; Yuen, K Y

    2004-04-01

    We describe a case of toxic scarlet fever in a healthy adult with streptococcal cellulitis of the right elbow as a result of skin abrasion. The clinical picture mimicked that of drug eruption after treatment of cellulitis with antibiotics. Among the five cases of scarlet fever complicating cellulitis, including the present one, reported in the English literature, four had severe systemic complications and two died. As a result of re-emergence of invasive streptococcal infections, clinicians should be aware of the differential diagnosis of scarlet fever in patients presenting with cellulitis and skin rash. Early clinical diagnosis is crucial to exclude drug eruptions, prompt initiation of antibiotic treatment, and prevention of the potentially fatal outcome.

  13. Parasitosis intestinales en poblaciones Mbya-Guaraní de la provincia de Misiones

    Directory of Open Access Journals (Sweden)

    Zonta, María Lorena

    2005-01-01

    Full Text Available El objetivo del trabajo consiste en describir las enteroparasitosis más frecuentes en dos comunidades Mbyá Guaraní de Misiones, Argentina: Kaaguy Poty (KP e Yvy Pytá (YP y su asociación con el estado nutricional y los factores ambientales y culturales que caracterizan a éstas poblaciones. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí (TA y la población urbana más cercana: Aristóbulo del Valle (AV. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se relevaron variables antropométricas (peso y estatura. Se analizaron también muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 88.5%(KP, 88.7%(YP, 96.1% (TA y 82%(AV estuvieron parasitados. De ellos, el 74.3% presentaron poliparasitosis. El 80.6 % de los individuos estaban desnutridos y más del 90% de ellos parasitados. Los datos se procesaron mediante pruebas de chi cuadrado. Los resultados mostraron asociación entre el uso de letrinas y Giardia lamblia (p<0.01; defecación a cielo abierto, ausencia de calzado y Ancilostomídeos (p<0.01 y entre el tipo de vivienda y la presencia de helmintos (p<0.01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  14. Peg-Interferon Alfa 2-b Related Cellulitis in a 40 Years Man

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    Shahnaaz Sali

    2016-01-01

    Full Text Available Background: Pegylated interferon and ribavirin are currently one of the accepted treatment for chronic Hepatitis C. Dermatologic complications of interferon have been reported, but to date a few cases of bacterial cellulitis; a rare and severe complication, have been published. Cellulitis is a common infectious process affecting the skin and subcutaneous tissues which results in significant morbidity and holds considerable healthcare costs.Cases Report: Herein, we report a case of chronic hepatitis C genotype 1a who was on medication since 8 weeks prior to developing leg cellulitis, an uncommon pegylated interferon injection site. Considering no other possible risk factors were found to be in favor of bacterial cellulitis, our case is unique in its kind. Some reports reveal necrotizing vasculitis as basis for cutaneous lesions, which could be due to the high concentrations of drug at the injection site, a toxic effect of the diluents, or an immunological reaction.Conclusion: According to the latter mechanism patients could develop bacterial cellulitis in their different organs. Conclusively, we propose the hypothesis of a possible association between cellulitis to occur at any site as the complication of pegylated interferon Alfa 2b and would highlight the role of a careful skin examination that could be an asset in preventing local skin infections.

  15. Bacterial Etiology and Risk Factors Associated with Cellulitis and Purulent Skin Abscesses in Military Trainees

    Science.gov (United States)

    Johnson, Ryan C.; Ellis, Michael W.; Schlett, Carey D.; Millar, Eugene V.; LaBreck, Patrick T.; Mor, Deepika; Elassal, Emad M.; Lanier, Jeffrey B.; Redden, Cassie L.; Cui, Tianyuan; Teneza-Mora, Nimfa; Bishop, Danett K.; Hall, Eric R.; Bishop-Lilly, Kimberly A.

    2016-01-01

    Military trainees are at high risk for skin and soft-tissue infections (SSTIs). Although Staphylococcus aureus is associated with purulent SSTI, it is unclear to what degree this pathogen causes nonpurulent cellulitis. To inform effective prevention strategies and to provide novel insights into SSTI pathogenesis, we aimed to determine the etiology of SSTI in this population. We conducted a prospective observational study in US Army Infantry trainees with SSTI (cutaneous abscesses and cellulitis) from July 2012 through December 2014. We used standard microbiology, serology, and high-throughput sequencing to determine the etiology of SSTI. Furthermore, we compared purported risk factors as well as anatomic site colonization for S. aureus. Among 201 SSTI cases evaluated for SSTI risk factors, cellulitis was associated with lower extremity blisters (P = 0.01) and abscess was associated with methicillin-resistant S. aureus (MRSA) colonization (Pmicrobiome analysis, only 1 leading edge aspirate was culturable (Coagulase-negative Staphylococcus). Microbiome evaluation of aspirate specimens demonstrated that Rhodanobacter terrae was the most abundant species (66.8% average abundance), while abscesses were dominated by S. aureus (92.9% average abundance). Although abscesses and cellulitis share the spectrum of clinical SSTI, the bacterial etiologies as determined by current technology appear distinct. Furthermore, the presence of atypical bacteria within cellulitis aspirates may indicate novel mechanisms of cellulitis pathogenesis. Clinical Trials Registration: NCT01105767. PMID:27780238

  16. Descripción Morfométrica de las vellosidades Intestinales en bovinos

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    Diana Avila

    2009-10-01

    Full Text Available El objetivo del estudio es realizar la caracterización de los parámetros histológicos del intestino delgado de bovinos adultos sacrificados en la planta debeneficio del municipio de Tunja Boyacá, relacionando la altura, el ancho y la cantidad de vellosidades con la superficie de absorción de nutrientes, para establecer mejores dietas, manejos nutricionales, sanitarios y asociar las patologías digestivas de mayor presentación en los bovinos de nuestra región. Para la metodología del estudio se tomaron muestras de (n=15 animales al azar sacrificados durante una semana. Se les tomaron muestras de intestino delgado (duodeno de 1 x 1cm, conservadas en formol al 10% y enviadas al laboratorio de Patología de la Universidad Nacional sede Bogotá, donde se les practicó la tinción de hematoxilina-eosina (H-E con previa inclusión en bloques de parafina. Las láminas se analizaron en el laboratorio de Ciencias Básicas de la Fundación Universitaria Juan de Castellanos, utilizando un microscopio Model con un aumento 4x y 10x en el objetivo, las mediciones se tomaron en valores de milímetros (mm. Se concluye que por campo observado se encuentran 4 vellosidades con una altura promedio de 0,521 mm y una desviación estándar de 0,13, ancho de 0,10mm y desviación estándar de 0,044. A medida que las vellosidades intestinales se encuentran cercanas a la parte craneal del intestino delgado de observaron en mayor cantidad por campo, más largas, uniformes y con un ancho de mayor longitud, lo que incrementa su superficie interna, facilitando los procesos de digestión y absorción.

  17. Cervical cellulitis and mediastinitis following esophageal perforation: A case report

    Institute of Scientific and Technical Information of China (English)

    Christian A Righini; Basilide Z Tea; Emile Reyt; Karim A Chahine

    2008-01-01

    Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation.Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management.We present the case of a 52-year-old man who sustained an upper esophageal perforation associated with cervical cellulitis and mediastinitis.Following CT-scan evidence of FB penetrating the esophagus,the impacted FB was successfully extracted under rigid esophagoscopy.Direct suture was required to close the esophageal perforation.Cervical and mediastinal drainage were made immediately.Nasogastric tube decompression,broad-spectrum intravenous antibiotics,and parenteral hyperalimentation were administered for 10 d postoperatively.An esophagogram at d 10 revealed no leak at the repair site,and oral alimentation was successfully reinstituted.Conclusion:Rigid endoscope management of FB esophageal penetration is a simple,safe and effective procedure.Primary esophageal repair with drainage of all affected compartments are necessary to avoid life-threatening complications.

  18. Nine years’ review on preseptal and orbital cellulitis and emergence of community–acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

    OpenAIRE

    Pandian, Datta G; Babu, Ramesh K; Chaitra, A; A Anjali; Vasudev A Rao; Renuka Srinivasan

    2011-01-01

    Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Setti...

  19. A case of odontogenic orbital cellulitis causing blindness by severe tension orbit.

    Science.gov (United States)

    Park, Chang Hyun; Jee, Dong Hyun; La, Tae Yoon

    2013-02-01

    We report a very rare case of odontogenic orbital cellulitis causing blindness by severe tension orbit. A 41-yr old male patient had visited the hospital due to severe periorbital swelling and nasal stuffiness while he was treated for a periodontal abscess. He was diagnosed with odontogenic sinusitis and orbital cellulitis, and treated with antibiotics. The symptoms were aggravated and emergency sinus drainage was performed. On the next day, a sudden decrease in vision occurred with findings of ischemic optic neuropathy and central retinal artery occlusion. Deformation of the eyeball posterior pole into a cone shape was found from the orbital CT. A high-dose steroid was administered immediately resulting in improvements of periorbital swelling, but the patient's vision had not recovered. Odontogenic orbital cellulitis is relatively rare, but can cause blindness via rapidly progressing tension orbit. Therefore even the simplest of dental problems requires careful attention.

  20. [Cellulitis due to Achromobacter xylosoxidans during bortezomib therapy for multiple myeloma].

    Science.gov (United States)

    Kikuchi, Taku; Mori, Takehiko; Kohashi, Sumiko; Yamane, Yusuke; Okayama, Mikio; Mashima, Eri; Murakami, Koichi; Shimizu, Takayuki; Kurihara, Yuichi; Ueda, Tomomi; Suzuki, Takeshi; Okamoto, Shinichiro

    2016-02-01

    Achromobacter xylosoxidans (A. xylosoxidans) is a non-fermentative gram-negative rod. This organism is reportedly a causative pathogen of bacteremia mainly in patients with hematological disorders. However, only one case of cellulitis due to A. xylosoxidans associated with hematological malignancy has been reported. An 80-year-old man developed cellulitis and subsequent bacteremia due to A. xylosoxidans during bortezomib therapy for multiple myeloma. Although his condition was serious enough to require intensive care, he fully recovered with appropriate antimicrobial agents and supportive care. The isolate was broadly resistant to antimicrobial agents, including cefepime, amikacin, and ciprofloxacin. Therefore, the identification and selection of appropriate antimicrobial agents were considered to have contributed to the successful outcome in this case. Physicians should recognize A. xylosoxidans as a possible pathogen causing cellulitis and secondary bacteremia, as well as being aware of its broad resistance to antimicrobial agents.

  1. Group a streptococcal cellulitis in the early puerperium

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    Nikolić Branka

    2011-01-01

    Full Text Available Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerperium. However, there are two main problems with GAS infection in early puerperium and this case report is aimed at reminding on them. The first problem is an absence of awareness that it can be postpartal invasive GAS infection before the microbiology laboratory confirms it, and the second one is that we have little knowledge about GAS infection, in general. Case report. A 32- year-old healthy woman, gravida 1, para 1, was hospitalized three days after vaginal delivery with a 38-hour history of fever, pain in the left leg (under the knee, and head injury after short period of conscious lost. Clinical picture of GAS infection was cellulites. Group A Streptoccocus pyogenes was isolated in vaginal culture. Rapid antibiotic and supportive treatment stopped development of streptococcal toxic shock syndrome (STSS and potential multiorganic failure. Signs and symptoms of the infection lasted 25 days, and complete recovery of the patient almost 50 days. Conclusion. In all women in childbed with a history of fever early after delivery, vaginal and cervical culture specimens should be taken as soon as possible. Early recognition of GAS infection in early puerperium and prompt initiation of antimicrobial drug and supportive therapy can prevent development of STSS and lethal outcome.

  2. ETUDE ET SIMULATION DE CELLULES PHOTOVOLTAIQUES A COUCHES MINCES A BASE DE CIS et CIGS

    OpenAIRE

    MOSTEFA KARA, Selma

    2012-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de Cu(In,Ga)Se2 semble prometteur. En effet, le rendement de ces cellules a dépassé les 20% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logiciel Si...

  3. A case of community-acquired Acinetobacter junii-johnsonii cellulitis.

    Science.gov (United States)

    Henao-Martínez, Andrés F; González-Fontal, Guido R; Johnson, Steven

    2012-06-01

    Acinetobacter skin and soft tissue infection outside of the traumatic wound setting are rare occurrences. The majority of cases occur in the presence of significant comorbilities and by Acinetobacter baumanii. Herein a case is reported of community-onset, health-care-associated, non-traumatic cellulitis caused by Acinetobacter, species junii-johnsonii with bacteremia. This is the first reported case of Acinetobacter junii-johnsonii skin and soft tissue infection. Hemorrhagic bullae might be one of the clinical features of Acinetobacter cellulitis.

  4. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

    Directory of Open Access Journals (Sweden)

    Juan Carlos Fernández Méndez

    2010-01-01

    Full Text Available En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mostraba valores en neuroticismo que se hallaban dentro de la normalidad; sin embargo, se pudo verificar que los valores diferían dependiendo del curso clínico de la patología. El estudio sugiere que las variaciones en neuroticismo son considerables cuando se analizan los datos de la muestra general y cuando se tienen en cuenta diversas condiciones del curso clínico.

  5. Concurrent Infections of Conidiobolus Coronatus with Disseminated Tuberculosis Presenting as Bilateral Orbital Cellulitis

    OpenAIRE

    John, Deepa; Irodi, Aparna; Michael, Joy Sarojini

    2016-01-01

    Zygomycetes species contains two orders of organisms that infect humans, namely Mucorales and Entomophthorales. Entomophthorales cause chronic infection in immunocompetent patients, invading subcutaneous tissues but are non-angioinvasive. This includes Basidiobolus ranarum, Conidiobolus incongruus and Conidiobolus coronatus. We report a case of disseminated tuberculosis with Conidiobolus coronatus infection presenting as orbital cellulitis in an adolescent.

  6. Panophthalmitis with orbital cellulitis following glaucoma drainage implant surgery in a pediatric patient

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    Bruno L. B. Esporcatte

    2016-04-01

    Full Text Available ABSTRACT Here we report a case of childhood glaucoma refractory to angle and trabeculectomy surgery. The patient was treated with an Ahmed™ drainage implant that was subsequently complicated by rapid-onset panophthalmitis and orbital cellulitis. Intravenous and intravitreal antibiotic therapy was initiated and the drainage tube was removed. The infectious process resolved within 3 weeks; however, phthisis bulbi developed subsequently.

  7. Current trends in treatment outcomes of orbital cellulitis in a tertiary hospital in Southern Nigeria

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    Odarosa M Uhumwangho

    2016-01-01

    Full Text Available Background: Orbital cellulitis refers to the inflammation or infection of the soft tissues of the orbit located behind the orbital septum. Aim: To determine the current trends in the outcomes following the management of orbital cellulitis in a tertiary hospital in Southern Nigeria. Patients and Methods: A retrospective review of medical records of patients with orbital cellulitis from January 2008 to December 2014 was conducted. The age, sex, duration of symptoms, predisposing factors, clinical findings, laboratory/radiological investigations, treatment provided, complications, and follow-up were recorded. Results were analyzed with SPSS Version 21 program. Results: Forty-two patients were seen made of 17 (40.5% males and 25 (59.5% females with a mean age of 18.2 ± 18.7 years of which children 6/18 at presentation, 38 (82.6% and at discharge, 39 (84.8%. The mean duration of presenting complaints was 15.5 ± 31.6 days. Patients who presented early were less likely to develop complications, P = 0.003. The most common complication was exposure keratopathy in 8 (44.4% eyes. The only surgical intervention performed was incision and drainage of abscess in 3 (7.1% eyes. No patient came for follow-up. Conclusion: Prompt institution of effective antibiotics and management of complications that may arise improves prognosis of orbital cellulitis.

  8. Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature.

    Science.gov (United States)

    Clark, Jeremy D; Fernandez de Castro, Juan P; Compton, Chris; Lee, Harold; Nunery, William

    2016-06-01

    Cedecea is a gram-negative bacterium from the family Enterobacteriaceae, rarely associated with human infection. We report the first case of an orbital cellulitis and corneal ulcer due to Cedecea in a patient who sustained a motor vehicle accident and was then found to have a retained wooden orbital foreign body.

  9. An aggressive group a streptococcal cellulitis of the hand and forearm requiring surgical debridement.

    Science.gov (United States)

    Bharucha, Neil J; Alaia, Michael J; Paksima, Nader; Christoforou, Dimitrios; Gupta, Salil

    2011-01-03

    Group A streptococcus is responsible for a diverse range of soft tissue infections. Manifestations range from minor oropharyngeal and cellulitic skin infections to more severe conditions such as necrotizing fasciitis and septic shock. Troubling increases in the incidence and the severity of streptococcal infections have been reported over the past 25 years. Cases of streptococcal necrotizing fasciitis have received significant attention in the literature, with prompt surgical debridement being the mainstay of treatment. However, cases of rapidly progressing upper extremity streptococcal cellulitis leading to shock and a subsequent surgical intervention have not been well described. This article presents a case of an 85-year-old woman with a rapidly progressing, erythematous, painful, swollen hand associated with fever, hypotension, and mental status change. Due to a high clinical suspicion for necrotizing fasciitis, the patient was rapidly resuscitated and underwent immediate surgical irrigation and debridement. All intraoperative fascial pathology specimens were negative for necrotizing fasciitis, leading to a final diagnosis of Group A streptococcal cellulitis. Although surgical intervention is not commonly considered in patients with cellulitis, our patient benefited from irrigation and debridement with soft tissue decompression. In cases of necrotizing fasciitis as well as rapidly progressive cellulitis, prompt diagnosis and aggressive treatment may help patients avoid the catastrophic consequences of rapidly progressive group A streptococcal infections.

  10. INCIDENCIA DE CASOS ESPORÁDICOS DE LAS INFECCIONES INTESTINALES MÁS FRECUENTES EN CASTELLÓN

    Directory of Open Access Journals (Sweden)

    Juan B. Bellido

    2003-01-01

    Full Text Available Fundamento: Las infecciones intestinales son procesos muy frecuentes de las que solo una parte son identificadas por los sistemas de vigilancia epidemiológica. El objetivo de este estudio es estimar la incidencia poblacional por grupos de edad de las infecciones intestinales esporádicas diagnosticadas en un área sanitaria de Castellón durante el año 2000. Métodos: A partir de los coprocultivos de rutina, se reunieron los datos demográficos básicos de cada enfermo para el cálculo de las tasas de diagnóstico y de hospitalización. En niños de hasta 5 años de edad se calcularon las tasas por año para cada microorganismo. Resultados: Campylobacterpresentó las tasas más altas (114,5 por 105, seguido de rotavirus (94,7 y Salmonella(83,0. Rotavirus predomina en menores de 1 año (3.194 x 105, Campylobacter en 1- 4 años, con un máximo de 3.850 por 105 en el segundo año de vida mientras Salmonella predominó en todas las edades a partir de los 5 años. Las tasas de casos hospitalizados tuvieron un patrón diferente, con rotavirus en primer lugar (34,9 por 105, Salmonella (21,7 por 105 y Campylobacter (9,9 por 105. Excepto Salmonella, no hubo brotes en ese periodo El predominio de Campylobacter se observó a expensas de los casos en niños de 1-4 años no hospitalizados. Conclusiones: Hasta los 4 años de edad la distribución de los gérmenes causantes de las infecciones es diferente para cada año. El conocimiento de la epidemiología descriptiva de estas infecciones contribuye al estudio de su impacto social y presta soporte para profundizar en algunas cuestiones que se plantean ante estas enfermedades y los aspectos preventivos que se puedan implementar.

  11. Nine years′ review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

    Directory of Open Access Journals (Sweden)

    Datta G Pandian

    2011-01-01

    Full Text Available Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Settings and Design : Retrospective descriptive case study done in a tertiary care hospital in South India. Material and Methods: The in-patient records of patients with preseptal and orbital cellulitis were reviewed from 1998 to 2006. The factors reviewed included ocular findings aiding in the distinction of the two clinical conditions, the duration of symptoms, the duration of hospital stay, microbiological culture report of pus or wound swab, blood culture, drugs used for treatment, the response to therapy and complications. Statistical Analysis Used: Descriptive analysis. Results: One hundred and ten cases, 77 patients with preseptal cellulitis and 33 patients with orbital cellulitis were reviewed. Five percent of children and 21% of adults presented with cutaneous anthrax contributing to preseptal cellulitis. Thirty-nine percent cases with orbital cellulitis were caused by methicillin-resistant Staphylococcus aureus (MRSA. Conclusions: This study has helped in identifying organisms which cause orbital infections, especially community-acquired MRSA. It indicates the need for modifying our empirical antimicrobial therapy, especially in orbital cellulitis.

  12. Predictors of a Positive Duplex Scan in Patients with a Clinical Presentation Compatible with Deep Vein Thrombosis or Cellulitis

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    Curtis E Rabuka

    2003-01-01

    Full Text Available BACKGROUND: Deep vein thrombosis (DVT and cellulitis are common conditions whose symptoms lead patients to seek medical attention in the emergency department (ED. Distinguishing between these two conditions quickly and accurately is important.

  13. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba

    Directory of Open Access Journals (Sweden)

    Fidel Angel Núñez

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (p<0,05, en las occidentales (p < 0,01, y en la totalidad (p < 0,01, lo que demonstró la efectividad a corto plazo de esta intervención. Sin embargo, pensamos que estas actividades de educación continuada deberian seguirse junto com programas nacionales para el control de la calidad.

  14. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba

    Directory of Open Access Journals (Sweden)

    Núñez Fidel Angel

    2001-01-01

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (p<0,05, en las occidentales (p < 0,01, y en la totalidad (p < 0,01, lo que demonstró la efectividad a corto plazo de esta intervención. Sin embargo, pensamos que estas actividades de educación continuada deberian seguirse junto com programas nacionales para el control de la calidad.

  15. Les conséquences d'un stress en période périnatale sur l'homéostasie intestinale et la réponse au microbiote à l'âge adulte

    OpenAIRE

    2015-01-01

    En période néonatale, la muqueuse intestinale est immature et particulièrement perméable, notamment aux facteurs environnementaux comme les toxiques, les infections mais aussi les événements stressants. De la bonne maturation de la barrière intestinale va dépendre la mise en place de l'homéostasie intestinale et donc la tolérance vis-à-vis des antigènes luminaux. La survenu d’évènements stressants durant la petite enfance est associée au déclenchement et/ou l’entretien de pathologies gastro-i...

  16. Mycobacterium avium-intracellulare cellulitis occurring with septic arthritis after joint injection: a case report

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    Murdoch David M

    2007-02-01

    Full Text Available Abstract Background Cellulitis caused by Mycobacterium avium-intracellulare has rarely been described. Mycobacterium avium-intracellulare is a rare cause of septic arthritis after intra-articular injection, though the causative role of injection is difficult to ascertain in such cases. Case presentation A 57-year-old with rheumatoid arthritis treated with prednisone and azathioprine developed bilateral painful degenerative shoulder arthritis. After corticosteroid injections into both acromioclavicular joints, he developed bilateral cellulitis centered over the injection sites. Skin biopsy showed non-caseating granulomas, and culture grew Mycobacterium avium-intracellulare. Joint aspiration also revealed Mycobacterium avium-intracellulare infection. Conclusion Although rare, skin and joint infections caused by Mycobacterium avium-intracellulare should be considered in any immunocompromised host, particularly after intra-articular injection. Stains for acid-fast bacilli may be negative in pathologic samples even in the presence of infection; cultures of tissue specimens should always be obtained.

  17. Facing the Danger Zone: The Use of Ultrasound to Distinguish Cellulitis from Abscess in Facial Infections

    Directory of Open Access Journals (Sweden)

    Dywanda L. Lewis

    2014-01-01

    Full Text Available Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1 emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2 demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3 depict an instance where ultrasound detected an abscess when computed tomography (CT scan did not.

  18. Densità e distribuzione delle cellule di Purkinje nel cervelletto di cane: studio immunoistochimico

    OpenAIRE

    Ruffini, Alessia

    2016-01-01

    Nella letteratura, gli studi morfologici e morfometrici del cervelletto di animali ed esseri umani, hanno valutato il numero di cellule di Purkinje (CP) solo su alcuni campi a random. Gli studi sono stati spesso condotti su cervelletti fissati in formalina e inclusi in paraffina; gli studi effettuati su campioni congelati sono molto rari. Gli scopi del presente studio sono stati: quantificare il numero e la distribuzione delle CP in tutto il tessuto cerebellare; valutare lo spessore del gr...

  19. Disseminated cryptococcosis presenting as cutaneous cellulitis in an adolescent with systemic lupus erythematosus

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    Ellen Simionato Valente

    2015-06-01

    Full Text Available We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

  20. Disseminated Cryptococcosis Presenting as Cutaneous Cellulitis in an Adolescent With Systemic Lupus Erythematosus.

    Science.gov (United States)

    Valente, Ellen Simionato; Lazzarin, Mauricio Costa; Koech, Bruno Lopes; da Rosa, Ralph Vighi; de Almeida, Rafael; de Oliveira, Umberto Lopes; Neugebauer, Maria Gertrudes Fernandes Pereira; Sacco, Alexander Gonüalves

    2015-04-15

    We report here the case of a 17-year-old girl from Pelotas, Brazil, with systemic lupus erythematosus and disseminated cryptococcal infection. Prior to diagnosis, she was a chronic user of corticosteroids and other immunosuppressive drugs. Her first symptoms were skin lesions that simulated bacterial cellulitis. Upon suspicion, we performed a biopsy and fungal infection was confirmed. Appropriate therapy was established, and the patient was discharged after 42 days of treatment in complete remission.

  1. Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

    OpenAIRE

    Sachiko Sakamoto; Naoki Oiso; Masakatsu Emoto; Shusuke Uchida; Ayaka Hirao; Yoichi Tatsumi; Itaru Matsumura; Akira Kawada

    2012-01-01

    Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression. Acute promyelocytic leukemia (acute myeloid leukemia M3) is caused by translocation of reciprocal chromosomal rearrangement t(15;17), which produces an oncogenic protein. We herein describe a 71-year-old man having cellulitis with leukocytopenia as a first sign of acute promyelocytic leukemia. Dermatologists and hematologists should keep in min...

  2. A Woman with Unilateral Rash and Fever: Cellulitis in the Setting of Lymphedema

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    Melissa Joseph

    2015-01-01

    Full Text Available Cellulitis in the setting of lymphedema is an uncommon but clinically important presentation to the emergency department. Stagnant lymph is an ideal medium for bacterial growth and progression can be rapid due to decreased ability to fight infection in the affected area. Infections are commonly caused by gram-positive cocci, though blood cultures are often negative. Treatment should be aimed at rapid initiation of antibiotics targeting these species. There may be a role for antibiotic prophylaxis in recurrent cases.

  3. Successful endoscopic management with Mitomycin C application for sinusitis with orbital cellulitis

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    Anil S Harugop

    2013-01-01

    Full Text Available Background: Sinusitis with orbital complication is a potentially fatal disease that has been known since the days of Hippocrates. Primary sinus infection is the most common cause of orbital cellulitis. It is an emergency that threatens not only vision but also life from complications such as meningitis, cavernous sinus thrombosis, and brain abscess. Surgical intervention is mandatory whenever antibiotic treatment fails. There are two surgical options for the drainage, an external approach via a Lynch incision and an intranasal endoscopic procedure. Materials and Methods: Five patients with orbital cellulitis secondary to acute on chronic rhinosinusitis were included in the study from the period of 2010 - 2011. All five patients did not respond to medical management and hence underwent endoscopic sinus surgery with treatment of orbital pathology. At the end of the surgical procedure Mitomycin C in a concentration of 0.4mg/ml was applied with a cottonoid for a period of 4 minutes to prevent chance of adhesion formation. Results: In this series 3 females and 2 male patient with orbital cellulitis secondary to acute on chronic rhinosinusitis underwent endoscopic sinus surgery with treatment of orbital pathology. All 5 patients showed subjective and objective improvement within one week of endoscopic management. Conclusion: Though antibiotics have altered the course of sinusitis, its grave complications still persist in our environment. The excellent results and the absence of any major complications of endoscopic sinus surgery and drainage of abscess with application of Mitomycin C can be recommended as the preferred surgical technique.

  4. European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate

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    Tsironi Evangelia E

    2012-05-01

    Full Text Available Abstract Background Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed description of a community-associated methicillin-resistant S. aureus ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial acquisition and treatment selection are also discussed. Case presentation A 28-day-old Caucasian boy was referred to our hospital with the diagnosis of right orbital cellulitis. His symptoms included right eye proptosis, periocular edema and redness. Empirical therapy of intravenous daptomycin, rifampin and ceftriaxone was initiated. The culture of pus yielded a methicillin-resistant S. aureus isolate and the molecular analysis revealed that it was a Panton-Valentine leukocidine-positive ST80 strain. The combination antimicrobial therapy was continued for 42days and the infection was successfully controlled. Conclusions Clinicians should be aware that young infants, even without any predisposing condition, are susceptible to orbital cellulitis caused by community-associated methicillin-resistant S. aureus. Prompt initiation of the appropriate empirical therapy, according to the local epidemiology, should successfully address the infection, preventing ocular and systemic complications.

  5. Características de la infección por geohelmintos intestinales en escolares primarios de la provincia de Las Tunas

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    Rebeca M. Laird Pérez

    2014-08-01

    Full Text Available Se realizó un estudio transversal descriptivo, en el período comprendido entre los meses de septiembre y diciembre de 2004, con el objetivo de caracterizar la infección por geohelmintos intestinales en escolares de la enseñanza primaria de la provincia de Las Tunas. Se estudiaron 1 342 escolares pertenecientes a 35 escuelas de los estratos urbano y rural de los ocho municipios de la provincia. De cada escolar se procesó una muestra de heces por los procedimientos Directo y Kato Katz y se practicó el método de Harada Moris cuando se observaron huevos de ancylostomídeos. A los escolares parasitados por geohelmintos se les determinó su condición clínica. Se obtuvo una prevalencia general de la infección por geohelmintos intestinales del 16,2%, con predominio de la intensidad general de la infección ligera. Los gusanos trichúridos fueron los más observados, asociados a la mayoría de las infecciones con intensidades ligeras y moderadas. Prevaleció el estado clínico asintomático con muy poca morbilidad específica, siendo el dolor abdominal y la diarrea no disentérica los síntomas más frecuentes. Se caracterizó a la provincia de Las Tunas como una zona hipoendémica de geohelmintos intestinales y se recomienda identificar los determinantes de la infección por estos parásitos en la población escolar

  6. Découverte d'une tumeur grêlique suite à une occlusion intestinale aigue chez une femme enceinte: à propos d'un cas

    OpenAIRE

    Chouaib, Naoufal; Rafai, Mostafa; El Bouti, Anas; Belkouch, Ahmed; El bakkali, Hicham; Belyamani, Lahcen

    2015-01-01

    L'association d'un cancer digestif avec la grossesse est rare et concerne avant tout les cancers colorectaux, de l'estomac ainsi que ceux se révélant par une tumeur de Krukenberg. Le diagnostic est souvent tardif expliquant la fréquence élevée des stades avancés. Nous rapportons un cas d'une femme enceinte qui a présenté une occlusion intestinale aigue sur tumeur colique. Il s'agissait d'une patiente enceinte de 32 semaines d'aménorrhées, admise pour syndrome occlusif évoluant depuis trois jo...

  7. Mebendazol en el tratamiento de helmintíasis intestinales revisión de literatura y consideraciones de Enfermería

    OpenAIRE

    Kogien, M.; Teixeira, C. A.

    2011-01-01

    Mebendazol es un antihelmíntico de amplio espectro, fármaco de elección para el tratamiento de varios tipos de infecciones parasitarias intestinales, además en la zona de la terapéutica farmacológica la enfermería tiene papel importante sea en la administración de medicamentos o en la nueva zona de actuación que surge para la profesión: la prescripción de medicamentos mediante protocolos o rutinas aprobados. Objetivos: realizar una revisión de literatura acerca de los aspectos farmacológi...

  8. Prevalencia de parásitos intestinales en manipuladores de alimentos en una comunidad rural de Cojedes, Venezuela

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    Gilberto Bastidas

    2012-12-01

    Full Text Available Introducción: las parasitosis intestinales constituyen un problema de salud pública, por la elevada prevalencia que muestran, donde los manipuladores de alimentos parasitados, se convierten en potenciales fuentes de infección, pues algunas formas parasitarias se transmiten directamente de la fuente de infección al susceptible, por vía fecal-oral. A esto se suma el incremento en el consumo de comida fuera del núcleo familiar, en residentes de zonas urbanas y rurales. El objeto es recolectar información para que las autoridades sanitarias implementen programas de salud acordes a cada región. Métodos: estudio descriptivo, de campo y transversal. Fueron 64 los manipuladores de alimentos, pero la muestra fue de 50. Se aplicó un cuestionario sobre prácticas higiénicas en la manipulación de alimentos, se determinó nivel socioeconómico y prevalencia de parasitosis por ensayos coproparasitológicos. Resultados: fueron 44 mujeres y 6 hombres; un 52% pertenecía al estrato IV; la mayoría conocía las prácticas higiénicas en la manipulación de alimentos, pero un 26% tenía alguna parasitosis intestinal; los parásitos más frecuentes fueron: E. nana (41,2% y B. hominis (38,7%; el monoparasitismo fue del 54%. Conclusión: en la presencia y frecuencia de una enfermedad parasitaria intestinal intervienen diversos factores. Por lo tanto, en manipuladores de alimentos, la educación ajustada al entorno, en buenas prácticas de higiene, es básica para prevenir la transmisión.

  9. Inflammatory tinea capitis mimicking dissecting cellulitis in a postpubertal male: a case report and review of the literature.

    Science.gov (United States)

    Stein, Loretta L; Adams, Erin G; Holcomb, Katherine Z

    2013-09-01

    Tinea capitis in postpubertal patients is unusual and may be misdiagnosed as dissecting cellulitis. We report a case of a healthy 19-year-old Hispanic male presenting with a 2-month history of a large, painful subcutaneous boggy plaque on the scalp with patchy alopecia, erythematous papules, cysts and pustules. Although initially diagnosed as dissecting cellulitis, potassium hydroxide evaluation (KOH preparation) of the hair from the affected region was positive. A punch biopsy of the scalp demonstrated endothrix consistent with tinea capitis, but with a brisk, deep mixed inflammatory infiltrate as can be seen with chronic dissecting cellulitis. Fungal culture revealed Trichophyton tonsurans, and a diagnosis of inflammatory tinea capitis was made. The patient was treated over the course of 17 months with multiple systemic and topical antifungal medications, with slow, but demonstrable clinical and histopathological improvement. A rare diagnosis in adults, clinicians should have a high index of suspicion for this condition in an adult with an inflammatory scalp disorder not classic for dissecting cellulitis or with a recalcitrant dissecting cellulitis. Prompt, appropriate diagnosis and treatment is necessary to prevent the long-term complications of scarring alopecia.

  10. Infectious diseases specialist management improves outcomes for outpatients diagnosed with cellulitis in the emergency department: a double cohort study.

    Science.gov (United States)

    Jain, Shilpa R; Hosseini-Moghaddam, Seyed M; Dwek, Philip; Gupta, Kaveri; Elsayed, Sameer; Thompson, Guy W; Dagnone, Robert; Hutt, Kelly; Silverman, Michael

    2017-04-01

    Three hospital emergency rooms (ERs) routinely referred all cases of cellulitis requiring outpatient intravenous antibiotics, to a central ER-staffed cellulitis clinic. We performed a retrospective cohort study of all patients seen by the ER clinic in the last 4months preceding a policy change (ER management cohort [ERMC]) (n=149) and all those seen in the first 3months of a new policy of automatic referral to an infectious disease (ID) specialist-supervised cellulitis clinic (ID management cohort [IDMC]) (n=136). Fifty-four (40%) of 136 patients in the IDMC were given an alternative diagnosis (noncellulitis), compared to 16 (11%) of 149 in the ERMC (P<0.0001). Logistic regression-demonstrated rates of disease recurrence were lower in the IDMC than the ERMC (hazard ratio [HR], 0.06; P=0.003), as were rates of hospitalization (HR, 0.11; P=0.01). There was no significant difference in mortality. Automatic ID consultation for cellulitis was beneficial in differentiating mimickers from true cellulitis, reducing recurrence, and preventing hospital admissions.

  11. Serratia marcescens Bullous Cellulitis in a Splenectomized Patient: A Case Report and Review of the Literature.

    Science.gov (United States)

    Fournier, John B; Dabiri, Ganary; Thomas, Vinod; Skowron, Gail; Carson, Polly; Falanga, Vincent

    2016-06-01

    Serratia marcescens is a Gram-negative bacillus belonging to the Enterobacteriaceae family. Cutaneous infection with Serratia is rare, and usually occurs in immunocompromised individuals. Primary cutaneous infections are uncommon, but they are typically severe and are associated with significant morbidity and mortality. The pathogenetic factors leading to S. marcescens infection are not fully understood, but contributing virulence factors include proteases, secreted exotoxins, and the formation of biofilm. We report a case of cellulitis occurring in a splenectomized patient, which led to multiple wound debridements and a transmetatarsal amputation. This dramatic case led us to review the published literature on soft tissue infections caused by S. marcescens.

  12. [Acute renal failure in a young male with cellulitis in the lower leg].

    Science.gov (United States)

    Rodríguez Lorenzo, A; Martelo Villar, F

    2008-06-01

    Necrotizing fascitiis due to Streptococcus Pyogenes has a high mortality rate. Detection of the infection before it developes to the streptococcal toxic shock syndrome is quite challenging and its one of the main goals of its management because at this final stage the treatment is in most of the cases ineffective. In a secuence of events of the progression of the infection to shock, renal failure occurs before hipotension very often. We report the case of a 38-year-old patient affected by a fulminant necrotizing fascitiis by Streptococcus Pyogenes which presented at admission with lower leg cellulitis and acute renal failure.

  13. Amelioration_du_Rendement_Energetique_de_Cellules_Photovoltaïques_en_Couches_Minces_a_base_de_CZTS.

    OpenAIRE

    BOUDJERAD_epouse_MEGHNINE, Fatiha

    2014-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de CuZnSnS4 (CZTS) semble prometteur. En effet, le rendement de ces cellules a dépassé les 30% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logic...

  14. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Soma Mukherjee

    2013-01-01

    Full Text Available Ludwig′s angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregnancy, lest life-threatening complications like Ludwig′s angina occur, complicating the course of pregnancy.

  15. An unusual pathogen in ambulatory care: two cases of Scedosporium soft tissue infections presenting as "unresponsive cellulitis".

    Science.gov (United States)

    Misselbrook, Gary Peter; Lillie, Patrick; Thomas, Claire P

    2016-01-01

    Soft tissue infections with Scedosporium spp. are an uncommon but serious and emerging cause of infection in immunocompromised patients. Acute Medical Units (AMUs) in the UK are increasingly managing patients with cellulitis in an outpatient setting, therefore acute physicians should be aware of some of the more uncommon causes of soft tissue infection, particularly in patients not responding to initial antibiotic therapy. We present two cases of Scedosporium presenting to the AMU as cellulitis not responding to initial antibiotic therapy and outline the assessment and management of this important condition.

  16. Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis

    Directory of Open Access Journals (Sweden)

    Giuseppe Valacchi

    2015-08-01

    Full Text Available Objectives: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. Material and Methods: We used the emergency department (ED visits data in Edmonton, Canada for the period from 1992 (April to 2002 (March. We retrieved all the diagnosed ED visits for cellulitis and pharyngitis. Case-crossover design was used to study potential association between ozone and those visits. Conditional logistic regression was used to estimate odds ratios (OR and their 95% confidence intervals (95% CI. Results: The results are reported for the interquartile range (IQR = 17.9 ppb for 8 h maximum ozone. Positive and statistical significant results were obtained as follows: for lags from 0 to 3 (OR = 1.07, 95% CI: 1.03–1.12, lag 2; for lags from 0 to 6 days (OR = 1.08, 95% CI: 1.03–1.12, lag 3; for lags from 0 to 4 (OR = 1.06, 95% CI: 1.03–1.09, for lag 2 and 3. Conclusions: The findings suggest the response to exposure to ambient ground-level ozone for skin and pharyngitis considered separately and jointly.

  17. A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.

    LENUS (Irish Health Repository)

    Quirke, M

    2014-11-01

    To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-referral, symptom duration of more than 48 hours and absence of pre-EO antibiotic therapy.

  18. Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis

    Directory of Open Access Journals (Sweden)

    Rebecca Sin Mei Lim

    2013-01-01

    Full Text Available We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.

  19. Caractérisation de flores microbiennes intestinale humaine et fromagère par méthode de métagénomique quantative

    OpenAIRE

    Almeida, Mathieu

    2013-01-01

    La flore microbienne est un ensemble de micro-organismes comme les bactéries, archées, eucaryotes inférieurs et virus, jouant un rôle important dans l’équilibre d’un écosystème. Cette flore reste encore mal définie car en 2012, seules ~30% des micro-organismes de la flore intestinale humaine étaient caractérisés, et moins de 50% des micro-organismes de la flore fromagère traditionnelle étaient caractérisés au niveau fonctionnel. Depuis 2006, les séquenceurs à ADN de seconde génération permett...

  20. Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases

    Directory of Open Access Journals (Sweden)

    Souleymane Brah

    2011-01-01

    Full Text Available Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. We describe three cases of severe infection due to C. fetus with cellulitis at presentation, but without any gastrointestinal symptoms, occurring in patients with acquired hypogammaglobulinemia.

  1. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    Directory of Open Access Journals (Sweden)

    Navone Graciela Teresa

    2006-01-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p < 0,01; defecación a cielo abierto, ausencia de calzado y ancilostomídeos (p < 0,01; el tipo de vivienda y los helmintos en general (p < 0,01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  2. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    Directory of Open Access Journals (Sweden)

    Graciela Teresa Navone

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p < 0,01; defecación a cielo abierto, ausencia de calzado y ancilostomídeos (p < 0,01; el tipo de vivienda y los helmintos en general (p < 0,01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  3. The acute orbit: Differentiation of orbital cellulitis from subperiosteal abscess by computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Handler, L.C.; Davey, I.C. (Groote Schuur Hospital, Cape Town (South Africa). Dept. of Neuroradiology Cape Town Univ. (South Africa)); Hill, J.C.; Lauryssen, C. (Groote Schuur Hospital, Cape Town (South Africa). Dept. of Ophthalmology Cape Town Univ. (South Africa))

    1991-02-01

    A series of 65 patients suffering from acute inflammatory disease of the orbit was studied by CT. Ethmoiditis was the cause in the vast majority; trauma and dental extraction played a lesser role in causation. Orbital cellulitis was diagnosed in 17 and subperiosteal abscess in the remaining 48. It was not possible to differentiate 33 pus-containing abscesses from the six with inflammatory masses (phlegmons). The satisfactory response to aggressive medical treatment in those patients with inflammatory masses that were not drained justifies a more conservative approach; surgical drainage being reserved for those with a deterioration in proptosis, ocular movements or vision. Six abscesses arose de novo, of which some were in the orbital fat rather than the subperiosteal space. (orig.).

  4. [Macrolane®: A severe case of calf cellulitis after modeling injection].

    Science.gov (United States)

    Chaput, B; Eburdery, H; Crouzet, C; Grolleau, J-L; Chavoin, J-P; Garrido, I

    2012-02-01

    In recent years, the market for resorbable injectables has been steadily expanding. The European Community's seal of approval (CE) is a sufficient guaranty to get them distributed. These injectables do not require official approval because they are considered to be "implantable medical devices" and not medicines. Macrolane(®)is a hyaluronic acid in gel form (NASHA [non-animal stabilized hyaluronic acid]) and has been on the French market since 2007. It can be injected into all areas except the face. It is highly cross-linked which, while slowing its absorption into the body, can also leave long-lasting residues. We report the first case of cellulitis after injection into the calf by a practitioner in his office.

  5. Facial and Periorbital Cellulitis due to Skin Peeling with Jet Stream by an Unauthorized Person

    Directory of Open Access Journals (Sweden)

    Asli Feride Kaptanoglu

    2014-01-01

    Full Text Available Technologies and devices for cosmetic procedures are developing with each passing day. However, increased and unauthorized use of such emerging technologies may also lead to increases in unexpected results and complications as well. Here, we report a case of facial cellulitis after a “beauty parlor” session of skin cleaning with jet stream peeling device in 19-year old female patient for the first time. Complications due to improper and unauthorized use of jet stream peeling devices may also cause doubts about the safety and impair the reputation of the technology as well. In order to avoid irreversible complications, local authorities should follow the technology and update the regulations where the dermatologists should take an active role.

  6. 眼外伤致眶蜂窝组织炎的护理%Nursing of Oribital Cellulitis Caused by Eye Injury

    Institute of Scientific and Technical Information of China (English)

    林丽萍; 胡淑英; 陈少娜

    2002-01-01

    To sum up 20 cases of nursing Oribital cellulitis caused by eye injury and suggest that it is important fornursing to pay close attention to patient's condition, to prevent cross infection and psychological nursing and to publicizehygiene element knowledge.

  7. Dissecting cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppura

    OpenAIRE

    Scheinfeld, Noah

    2014-01-01

    Dissecting cellulitis (DC) also referred to as to as perifolliculitis capitis abscedens et suffodiens (Hoffman) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. In the U.S., it predominantly occurs in African American men between 20-40 years of age.  DC also occurs in other races and women more rarely.  DC has been reported worldwide.  Older therapies reported effective include: low dose oral zinc, isotretinoin, minocycline, sulfa drug...

  8. Incidencia de casos esporádicos de las infecciones intestinales más frecuentes en Castellón

    Directory of Open Access Journals (Sweden)

    Bellido Juan B

    2003-01-01

    Full Text Available Fundamento: Las infecciones intestinales son procesos muy frecuentes de las que solo una parte son identificadas por los sistemas de vigilancia epidemiológica. El objetivo de este estudio es estimar la incidencia poblacional por grupos de edad de las infecciones intestinales esporádicas diagnosticadas en un área sanitaria de Castellón durante el año 2000. Métodos: A partir de los coprocultivos de rutina, se reunieron los datos demográficos básicos de cada enfermo para el cálculo de las tasas de diagnóstico y de hospitalización. En niños de hasta 5 años de edad se calcularon las tasas por año para cada microorganismo. Resultados: Campylobacter presentó las tasas más altas (114,5 por 10(5, seguido de rotavirus (94,7 y Salmonella (83,0. Rotavirus predomina en menores de 1 año (3.194 x 10(5, Campylobacter en 1-4 años, con un máximo de 3.850 por 10(5 en el segundo año de vida mientras Salmonella predominó en todas las edades a partir de los 5 años. Las tasas de casos hospitalizados tuvieron un patrón diferente, con rotavirus en primer lugar (34,9 por 10(5, Salmonella (21,7 por 10(5 y Campylobacter (9,9 por 10(5. Excepto Salmonella, no hubo brotes en ese periodo El predominio de Campylobacter se observó a expensas de los casos en niños de 1-4 años no hospitalizados. Conclusiones: Hasta los 4 años de edad la distribución de los gérmenes causantes de las infecciones es diferente para cada año. El conocimiento de la epidemiología descriptiva de estas infecciones contribuye al estudio de su impacto social y presta soporte para profundizar en algunas cuestiones que se plantean ante estas enfermedades y los aspectos preventivos que se puedan implementar.

  9. Carcinoma a cellule basali: l'esperienza della dermatologia dell'Universita' di Bologna dal 1990 al 2014

    OpenAIRE

    Gaspari, Valeria

    2015-01-01

    Il carcinoma a cellule basali (BCC) costituisce l'80 peercento dei tumori cutanei non-melanoma, rappresentando dunque il tumore maligno della cute più frequente nella popolazione generale. Tuttavia, non esistono ad oggi studi epidemiologici ampi ed approfonditi condotti su scala nazionale su questo tipo di neoplasia, poichè i tumori cutanei non-melanoma sono esclusi dal registro statistico dei tumori. A tale scopo presso la Dermatologia dell'Università di Bologna sono stati raccolti di tut...

  10. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    Directory of Open Access Journals (Sweden)

    Juan S. Lasa

    2012-08-01

    Full Text Available La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB. Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celulitis. Se analizaron retrospectivamente los registros clínicos de los pacientes con este diagnóstico al ingreso entre junio de 2007 y marzo de 2010. Se evaluaron los datos poblacionales, presencia de comorbilidades, y resultados de los cultivos. En ese período, se internaron 140 pacientes con diagnóstico de celulitis y a todos ellos se les realizó hemocultivo y cultivos de PPB. Setenta y cuatro eran varones (52.8%. La edad promedio: 47.5 ± 19.7 años (rango 16-94. El 40% tuvo cultivos positivos de PPB, en los que el Staphylococcus aureus meticilino resistente (SAMR fue el germen más frecuentemente aislado (35.7%; la prevalencia de bacteriemia fue del 8.6%, en donde el germen más frecuente fue Streptoccocus Beta hemolítico, grupo G (33% del total de hemocultivos positivos. La bacteriemia se asoció significativamente a mayor estadía hospitalaria (10.5 ± 8.9 vs. 4.9 ± 6, p = 0.004. Se asoció con mayor riesgo de hemocultivo positivo a ser diabético, tener cultivo de PPB positivo, consumo de alcohol y/o enfermedad pulmonar obstructiva crónica.Cellulitis is an acute inflammation of dermis and subcutaneous tissue, usually complicating wounds, ulcers, or dermatosis. Even though in these cases it is recommended to perform culture from skin and soft tissue samples, the utility of blood cultures remains controversial due to the low frequency of positive results. Here we report the prevalence of bacteremia in patients with cellulitis admitted in our

  11. Juvenile cellulitis in a puppy – case reportsCelulite juvenil canina – relato de casos

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Fonseca-Alves

    2012-08-01

    Full Text Available Juvenile cellulitis or juvenile sterile granulomatous lymphadenitis is a rare disorder that affects puppies between three weeks to six months years old. Clinical signs include alopecia, edema, papules, pustules and crusts especially on eyelids. Definitive diagnosis requires cytological and histological evaluation and early and aggressive therapy is recommended, once scars after recovery can be severe .The choice treatment is the high dose of corticosteroids use such as prednisone. Three animals of canine species were attended at the Veterinary Hospital Clinical Small Animal Service presenting different clinical signs. Hemogram, skin lesions and submandibular lymph nodes cytological examination was collected and analyzed. The treatment was instituted, using cephalexin (22mg/kg, twice daily up to control of secondary bacterial infection, and prednisone (2mg/kg, once a day until clinical resolution. Complete cure was obtained at the end of treatment. The aim of this work is to report three clinical cases of juvenile cellulitis in dogs. A celulite juvenil ou linfadenite granulomatosa estéril juvenil, é um distúrbio raro que acomete filhotes com idade entre três semanas a seis meses. Os sinais clínicos incluem alopecia, edema, pápulas, pústulas e crostas especialmente em pálpebras. O diagnóstico definitivo requer exames citológico e histopatológico e a terapia precoce e agressiva é preconizada, pois as cicatrizes após recuperação podem ser graves. O tratamento de escolha consiste no uso de altas doses dos glicocorticoides, como prednisona. Foram atendidos no Hospital Veterinário, três animais da espécie canina, apresentando sinais clínicos variados. Foram realizados hemograma, exame citológico das lesões de pele e dos linfonodos submandibulares. O tratamento foi instituído, utilizando-se cefalexina na dose de 22 mg/kg, duas vezes ao dia, até controle de infecção bacteriana secundária e prednisona na dose de 2mg/kg, uma vez

  12. A case of cellulitis of the hands caused by a predatory bird attack

    Institute of Scientific and Technical Information of China (English)

    M Adil Abbas Khan; Mohammed Farid; Zain A Sobani; Syed Nadir Ali; Huzaifa Malick; Maryam Baqir; Hasanat Sharif; M Asim Beg

    2011-01-01

    Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  13. Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report

    Directory of Open Access Journals (Sweden)

    Probst Corina

    2010-08-01

    Full Text Available Abstract Background Cryptococcus neoformans is an encapsulated yeast and the most frequent cryptococcal species found in humans. Cryptococcosis is considered an opportunistic infection as it affects mainly immunosuppressed individuals. In humans, C. neoformans causes three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and wound or cutaneous cryptococcosis. Case Presentation An 81-year-old woman developed severe necrotizing cellulitis on her left arm without any preceding injury. The patient had been treated with systemic corticosteroids over twenty years for rheumatoid arthritis (RA. Skin biopsies of the wound area were initially interpreted as cutaneous vasculitis of unknown etiology. However, periodic acid Schiff staining and smear analysis later revealed structures consistent with Cryptococcus neoformans, and the infection was subsequently confirmed by culture. After the initiation of therapy with fluconazole 400 mg per day the general condition and the skin ulcers improved rapidly and the patient was discharged to a rehabilitation facility. Subsequently surgical debridement and skin grafting were performed. Conclusions Opportunistic infections such as cryptococcosis can clinically and histologically mimic cutaneous vasculitis and have to be investigated rigorously as a differential diagnosis in immunosuppressed patients.

  14. A case of cellulitis of the hands caused by a predatory bird attack

    Directory of Open Access Journals (Sweden)

    M Adil Abbas Khan

    2011-04-01

    Full Text Available Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an 80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  15. Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis

    Science.gov (United States)

    Kong, Benjamin Y.; Chou, Shaun; Wakade, Deepal; Carlino, Matteo S.; Fernandez-Penas, Pablo

    2017-01-01

    There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Six weeks later, the patient developed fever and a spreading erythematous tender indurated plaque covering the left side of the body including axillae, back, and flank, clinically suggestive of cellulitis. Systemic antibiotic therapy did not improve the condition and a biopsy showed sparse lymphocytic infiltrate. With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. This case highlights that, in patients with lymphadenectomy, atypical forms of lymphedema on the body may appear. Truncal lymphedema is an infrequent event. PMID:28182109

  16. Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.

    Science.gov (United States)

    Hau, Estelle; Bouaziz, Jean-David; Lafaurie, Matthieu; Saussine, Anne; Masson, Vincent; Rausky, Jonathan; Bagot, Martine; Guibal, Fabien

    2016-03-01

    Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.

  17. Peritonsillar abscess and cellulitis and their relation to a positive antigen detection test for streptococcal infection.

    Science.gov (United States)

    Risberg, Stefan; Engfeldt, Peter; Hugosson, Svante

    2010-10-01

    The microbiological cause of peritonsillar abscess and the role of group A β-haemolytic Streptococcus (GAS) are unclear. We performed a retrospective study at the ear, nose and throat clinic (ENT) of Orebro University Hospital, Sweden, and included 376 events of peritonsillitis between 2002 and 2004. We determined if the patients had visited a primary healthcare centre (PHCC) within 30 days prior to inclusion. The results of the rapid antigen detection test for GAS (Strep A) taken at the PHCC were compared with the occurrence of peritonsillar abscess (PTA) and peritonsillar cellulitis (PTC). A Strep A test was performed in 61% (229/376) of the events studied. Strep A was positive in 22% of PTA events and in 35% of PTC events (p = 0.036). Of 48,000 Strep A tests taken in primary healthcare, mainly for sore throat, 22% were positive. We examined the relationship between age, the incidence of PTA, and positive Strep A tests. We also determined if there was a monthly correlation between number of positive Strep A tests and number of PTA events. We found no significant correlations. In conclusion, our findings indicate that GAS does not play a major role in the development of PTA/PTC.

  18. Laser Capture Microdissection of Feline Streptomyces spp Pyogranulomatous Dermatitis and Cellulitis.

    Science.gov (United States)

    Traslavina, R P; Reilly, C M; Vasireddy, R; Samitz, E M; Stepnik, C T; Outerbridge, C; Affolter, V K; Byrne, B A; Lowenstine, L J; White, S D; Murphy, B

    2015-11-01

    Suspected Streptomyces spp infections were identified in 4 cats at UC Davis Veterinary Medical Teaching Hospital between 1982 and 2011. Three had ulcerated, dark red mycetomas involving the dermis, subcutis, and fascia with fistulous tracts and/or regional lymphadenopathy. One cat had pyogranulomatous mesenteric lymphadenitis. Granulomatous inflammation in all cats contained colonies of Gram-positive, non-acid-fast organisms. All 4 cats failed to respond to aggressive medical and surgical treatment and were euthanized. Laser capture microdissection (LCM) was used to selectively harvest DNA from the affected formalin-fixed, paraffin-embedded (FFPE) tissues. Cloned amplicons from LCM-derived tissue confirmed the presence of Streptomyces spp in the dermatitis cases. Amplicons from the remaining cat with peritoneal involvement aligned with the 16S ribosomal RNA gene for Actinomycetales. Usually considered a contaminant, Streptomyces spp can be associated with refractory pyogranulomatous dermatitis and cellulitis in cats with outdoor access. LCM is useful in the diagnosis of bacterial diseases where contamination may be an issue.

  19. Facial Candida albicans cellulitis occurring in a patient with oral submucous fibrosis and unknown diabetes mellitus after local corticosteroid injection treatment.

    Science.gov (United States)

    Chen, Hsin-Ming; Shih, Chiang-Ching; Yen, K Lawrence; Wang, Sheng-Ming; Kuo, Ying-Shiung; Kuo, Mark Yen-Ping; Chiang, Chun-Pin

    2004-04-01

    Facial cellulitis caused by odontogenic bacterial infection is frequently encountered; however, facial cellulitis caused by Candida albicans infection is rarely found. A patient with oral submucous fibrosis (OSF) and unknown diabetes mellitus (DM) was treated in our out-patient dental clinic by biweekly submucosal injection of 40 mg triamcinolone acetonide into bilateral buccal mucosae plus forced mouth opening performed by the two hands of the clinician. The interincisal distance of the patient improved from 28 to 48 mm after four times of steroid injection. The symptoms and signs of OSF also improved markedly. Unfortunately, facial candidal cellulitis occurred 2 months after the last time of steroid injection treatment. The infection was cured by incision and drainage, intravenous administration of amphotericin B (100 mg once a day for a week), and an appropriate medical control of DM. No recurrence of facial cellulitis was found during the follow-up period of 18 months. To prevent the occurrence of facial cellulitis after a high-dose steroid therapy, some prophylactic procedures should be taken before the initiation of the steroid treatment.

  20. Impact de l’âge et du microbiote sur l’expression intestinale des défensines chez les oiseaux

    OpenAIRE

    Bencherit, Djihad; Marty, Hélène; Trotereau, Angelina; Chanteloup, Nathalie; Brée, Annie; Schouler, Catherine

    2012-01-01

    Les défensines aviaires appartiennent à la grande famille des peptides antimicrobiens qui sont des composants clés de l’immunité innée des muqueuses [1]. Ces molécules peuvent être produites par les granulocytes et les cellules épithéliales [2]. Elles peuvent être purifiées à partir de la moelle osseuse du poulet et sont actives contre un panel de souches bactériennes Gram+ et Gram- [3]. L’expression des gènes des deux défensines aviaires majeures (AvBD1 et AvBD2) dans le tissu intestinal es...

  1. Occlusion intestinale aigue révélant un lymphome T digestif associé à la maladie cœliaque, à propos d'un cas

    Science.gov (United States)

    Garba, Abdoul Aziz; Adamou, Harissou; Magagi, Ibrahim Amadou; Brah, Souleymane; Habou, Oumarou

    2016-01-01

    Le lymphome T intestinal associé à une entéropathie ou Enteropathy associated T-cell lymphoma (EATL), est une complication rare de la maladie cœliaque (MC). Nous rapportons l'observation d'un lymphome T associée à une MC révélé par une occlusion intestinale aigue. Une patiente maghrébine de 38 ans, aux antécédents de stérilité et de douleurs abdominales chroniques, était admise en urgence pour occlusion intestinale aigue. L'intervention chirurgicale retrouvait une tumeur au dépend du grêle avec des adénopathies mésentériques. L'histologie et l'immunohistochimie de la pièce opératoire objectivait un lymphome T digestif CD3+ et le bilan immunologique de la maladie cœliaque était positif. Le diagnostic d'EATL était ainsi retenu. La patiente était mise sous chimiothérapie (CHOEP) et régime sans gluten avec une réponse complète au traitement. L'EATL est une complication rare de la MC qui peut être révélée par une occlusion intestinale. Son pronostic peut être amélioré par une prise en charge précoce associant chirurgie et chimiothérapie. Sa prévention passe par un diagnostic précoce de la MC et un régime sans gluten. PMID:27217874

  2. Prevalencia de parásitos intestinales en niños de diferentes niveles de educación del distrito de San Marcos, Ancash, Perú.

    OpenAIRE

    Jacinto, Eleuterio; Facultad de Medicina, Universidad Privada San Pedro, Chimbote.; Aponte, Edwin; Centro de Salud de San Marcos, Microred San Marcos, Ancash.; Arrunátegui-Correa, Víctor; Municipalidad Distrital de San Marcos, Ancash.

    2012-01-01

    Objetivo: Investigar la prevalencia de parasitosis intestinal en estudiantes del Distrito de San Marcos, en el departamento de Ancash, Perú. Material y métodos: Se analizaron en total 1303 muestras de heces de niños de nivel inicial, primario y secundario, mediante examen directo. Resultados: Se encontró uno o más parásitos intestinales en 65,0% de los estudiantes. De las 845 muestras positivas para parásitos, se encontró un parasito en 82,0% dos en18,0% predominando los protozoarios sobre lo...

  3. Parasitosis intestinales y factores socio-sanitarios en niños del área rural del distrito de Los Baños del Inca, Cajamarca-Perú

    OpenAIRE

    Rodríguez-Ulloa, Claudia; Bióloga-Microbióloga. Maestra en Salud Pública. Laboratorio de Microbiología y Parasitología, Universidad Nacional de Cajamarca, Cajamarca.; Rivera-Jacinto, Marco; Biólogo-Microbiólogo. Maestro en Ciencias. Laboratorio de Microbiología y Parasitología, Universidad Nacional de Cajamarca, Cajamarca.; Saucedo-Duran, Edith; Estudiante de obstetricia de la Universidad Nacional de Cajamarca, Cajamarca.; Rojas-Huamán, Yessica; Estudiante de obstetricia de la Universidad Nacional de Cajamarca, Cajamarca.; Valdivia-Meléndez, Nayeli; Estudiante de obstetricia de la Universidad Nacional de Cajamarca, Cajamarca.; Cabanillas-Vásquez, Quely; Estudiante de obstetricia de la Universidad Nacional de Cajamarca, Cajamarca.; Blanco-Burga, Hebert; Estudiante de obstetricia de la Universidad Nacional de Cajamarca, Cajamarca.

    2011-01-01

    Sr. Editor: La parasitosis intestinal, de alta incidencia en los niños, es un importante problema de salud pública en Cajamarca, y agrupadas dentro de las enfermedades infecciosas intestinales constituyen una de las diez primeras causas de morbilidad y de mortalidad en este grupo poblacional (1). La alta ruralidad de la región cajamarquina es favorable, desde el punto de vista epidemiológico, socioeconómico y ecológico, para que los niños ...

  4. Cambios en la composición de la grasa y en la histomorfología del hígado tras resecciones intestinales parciales Changes in the fat composition and histomorphology of the liver after partial intestinal resections

    OpenAIRE

    Mª I. Correa Antúnez; J. M. Morán Penco; J. L. Amaya Lozano; A. Leal Macho; E. Maciá Botejara; J. Saenz Santamaría

    2010-01-01

    Introducción y objetivos: Teóricamente, las resecciones intestinales parciales podrían afectar al hígado a través de la absorción de nutrientes y de la circulación enterohepática de los ácidos biliares, por las posibles alteraciones sobre el complejo hormonal duodeno-bilo-hepato-pancreático y por los efectos secundarios de la translocación bacteriana intestinal. Estos mecanismos fisiopatológicos pueden sumarse modificando la composición y la histomorfología hepática, específicamente la compos...

  5. Implications and applications of systematic reviews for evidence-based dentistry and comparative effectiveness research: A sample study on antibiotics for oro-facial cellulitis treatment

    Directory of Open Access Journals (Sweden)

    Quyen Bach

    2015-01-01

    Full Text Available Introduction: Comparative effectiveness and efficacy research for analysis and practice (CEERAP was performed to assess the effects of penicillin-based versus erythromycin-based antibiotic treatments in patients with skin and soft tissue infections (SSTIs including cellulitis, impetigo, and erysipelas. Because SSTIs, especially orofacial cellulitis, are volatile infectious diseases of a life-threatening nature, research on the most efficacious remedies is necessary. Methods: The stringent bibliome yielded three systematic reviews, which were examined for quality of research synthesis protocol and clinical relevance. Results: The sample size of three, rendered the statistical analyses and cumulative meta-analysis problematic. Conclusion: The systematic review outlined here should aid in increasing clinical awareness, improving patient health literacy, and promoting consensus of the best evidence base (BEB to mitigate the threat of sepsis and potential death caused by cellulitis infections.

  6. Dinámica para la identificación de las formas parasitarias microscópicas de los geohelmintos intestinales

    Directory of Open Access Journals (Sweden)

    Rebeca Margarita Laird Pérez

    2015-11-01

    Full Text Available Las estadísticas sobre geohelmintos intestinales, a partir del examen parasitológico de las heces, constituye la espina dorsal de los programas para el control de estos gusanos, pues a partir de ellas se obtiene información útil para la toma de decisiones; no obstante, existen insuficiencias cognoscitivas y en las habilidades para la identificación de formas microscópicas de geohelmintos por parte del personal del laboratorio, así como deficiencias didácticas en el abordaje bibliográfico sobre aspectos de interés para la identificación parasitaria, lo cual contribuye al reporte de errores en el laboratorio. Con vistas a contribuir al mejor diagnóstico de estos agentes parasitarios se elaboró el presente artículo, en el período de enero a marzo de 2013. Se realizó una amplia revisión bibliográfica y se diseñó una dinámica de identificación con énfasis en los detalles morfo-biológicos. Se concluye en la importancia del estudio del número y características de las cubiertas y contenido ovular en los inconvenientes de reportar las especies del género Trichuris, si no se emplean oculares micrométricos, en la utilidad de considerar la posible presencia de especies antropozoonóticas y de realizar el diagnóstico diferencial con los huevos y las larvas de otros helmintos presentes en las heces, con los que se comparten similitudes morfológicas.

  7. Estado nutricional y parasitosis intestinales en niños residentes en zonas urbana, periurbana y rural del partido de Brandsen (Buenos Aires, Argentina

    Directory of Open Access Journals (Sweden)

    Cesani Rossi, María Florencia

    2007-01-01

    Full Text Available El presente estudio tuvo como objeto analizar el estado nutricional y las parasitosis intestinales en niños de 3 a 6 años de edad, residentes en zonas urbanas (U, periurbanas (PU y rurales (R del partido de Brandsen. La muestra quedó constituida por 600 niños (302 varones y 298 mujeres. Los valores P85#P95 definieron sobrepeso y >P95 obesidad. Se tomaron muestras de materia fecal seriada y escobillado anal que fueron analizadas mediante técnicas de concentración por sedimentación (Ritchie y flotación (Willis. Los datos fueron asociados con las características socioambientales de cada zona. PU presentó prevalencias de baja talla para la edad y parasitosis significativamente mayores que U (p<0.01. Se registraron 7 especies parásitas en U, 8 en PU y 4 en R, siendo Enterobius vermicularis, Blastocystis hominis y Giardia lamblia las especies más abundantes. También el poliparasitismo fue mayor en PU. Aunque el sobrepeso y la obesidad fueron elevados en las tres zonas, las mayores prevalencias se registraron en PU y R respecto de U (p<0.01. La coexistencia de desnutrición y sobrepeso-obesidad, podría vincularse con los cambios experimentados en las costumbres alimentarias y los modos de vida de estas poblaciones en el contexto de la transición nutricional. La zona periurbana presenta las peores condiciones socio-ambientales para el crecimiento y la salud de los niños en edad preescolar.

  8. [Infectious cellulitis of the face complicating injection for esthetic nasolabial sulcus by hyaluronic acid: report of seven cases].

    Science.gov (United States)

    Chader, H; Bosc, R; Hersant, B; Lange, F; Hermeziu, O; Zehou, O; Chosidow, O; Meningaud, J-P

    2013-12-01

    We report a case series of seven patients with bacterial cellulitis of the face complicating a filler injection for cosmetic reason, treated in a university hospital from 2005 to 2012. There were seven women aged 34 to 57 years. Two patients had a deep collection requiring surgical excision combined with antibiotics. Five patients were treated with antibiotics only. In two cases the bacteria was found streptococcus A and in one case Staphylococcus aureus. One patient required hospitalization in an intensive care unit. Only patients who needed surgical treatment showed moderate aesthetic sequelae.

  9. Ultrahigh-rate supercapacitors with large capacitance based on edge oriented graphene coated carbonized cellulous paper as flexible freestanding electrodes

    Science.gov (United States)

    Ren, Guofeng; Li, Shiqi; Fan, Zhao-Xia; Hoque, Md Nadim Ferdous; Fan, Zhaoyang

    2016-09-01

    Large-capacitance and ultrahigh-rate electrochemical supercapacitors (UECs) with frequency response up to kilohertz (kHz) range are reported using light, thin, and flexible freestanding electrodes. The electrode is formed by perpendicularly edge oriented multilayer graphene/thin-graphite (EOG) sheets grown radially around individual fibers in carbonized cellulous paper (CCP), with cellulous carbonization and EOG deposition implemented in one step. The resulted ∼10 μm thick EOG/CCP electrode is light and flexible. The oriented porous structure of EOG with large surface area, in conjunction with high conductivity of the electrode, ensures ultrahigh-rate performance of the fabricated cells, with large areal capacitance of 0.59 mF cm-2 and 0.53 mF cm-2 and large phase angle of -83° and -80° at 120 Hz and 1 kHz, respectively. Particularly, the hierarchical EOG/CCP sheet structure allows multiple sheets stacked together for thick electrodes with almost linearly increased areal capacitance while maintaining the volumetric capacitance nearly no degradation, a critical merit for developing practical faraday-scale UECs. 3-layers of EOG/CCP electrode achieved an areal capacitance of 1.5 mF cm-2 and 1.4 mF cm-2 at 120 Hz and 1 kHz, respectively. This demonstration moves a step closer to the goal of bridging the frequency/capacitance gap between supercapacitors and electrolytic capacitors.

  10. Submandibular cellulitis (Ludwig's angina) associated to a complex odontoma erupted into the oral cavity. Case report and literature review.

    Science.gov (United States)

    Bertolai, R; Acocella, A; Sacco, R; Agostini, T

    2007-01-01

    The clinical presentation of Ludwig's angina consists in a severe expanding cellulitis causing swelling of the floor of the mouth, tongue and submandibular region, thus resulting in a possible obstruction of the airway and in a rapid progress in deep neck soft tissue infection and mediastinitis with potentially fatal consequences. Frequently, submandibular cellulitis develops from an acute infection spreading from the lower molar teeth. Mandibular fractures, traumatic laceration of the floor of the mouth, and peritonsillar abscesses are other concomitant clinical features. A case of Ludwig's angina associated with a large erupted odontoma and with a deeply impacted third molar displaced to the border of the mandible is described. The patient was affected by enlargement of submandibular space, marked face swelling causing an evident face deformity, tenderness and redness of the neck and limited movement of the neck and mouth. In the past, Ludwig's angina was frequently fatal, however aggressive surgical and medical therapy have significantly reduced the mortality rate. The reported case can be considered as important, not only because of the rarity of the odontoma eruption in the oral cavity, but mainly for the extent of the clinical manifestation of a lesion usually described in literature as asymptomatic.

  11. Non-suppurative cellulitis: risk factors and its association with Staphylococcus aureus colonization in an area of endemic community-associated methicillin-resistant S. aureus infections.

    Science.gov (United States)

    Eells, S J; Chira, S; David, C G; Craft, N; Miller, L G

    2011-04-01

    Suppurative methicillin-resistant Staphylococcus aureus (MRSA) skin infections are common and associated with MRSA colonization, but little is known about non-suppurative cellulitis and its relationship with MRSA colonization in areas endemic for community-associated MRSA. We prospectively enrolled patients hospitalized for non-suppurative cellulitis (n=50) and matched controls (n=100) and found S. aureus colonization was similar in cases and controls (30% vs. 25%, P=0·95). MRSA was uncommon in cases (6%) and controls (3%) (P=0·39). All MRSA isolates were USA300 by pulsed-field gel electrophoresis. Independent risk factors for non-suppurative cellulitis were diabetes (OR 3·5, 95% CI 1·4-8·9, P=0·01) and homelessness in the previous year (OR 6·4, 95% CI 1·9-20·9, P=0·002). These findings suggest that MRSA may only rarely be causative of non-suppurative cellulitis.

  12. EVALUACIÓN DEL EFECTO DE LA SUPLEMENTACIÓN DE LEVADURAS SOBRE LA MORFOMETRÍA DE VELLOSIDADES INTESTINALES Y PRODUCTOS DE LA MICROFLORA EN POLLOS

    Directory of Open Access Journals (Sweden)

    N. Lópes

    2008-01-01

    Full Text Available entre las estrategias desarrolladas para mejorar las condiciones funcionales del tracto gastrointestinal (TGi de las aves se encuentra el empleo de nuevos aditivos funcionales alimenticios, y dentro de estas posibilidades está el uso de levaduras. el objetivo de este estudio fue evaluar el potencial funcional y nutricional de tres diferentes cepas de leva-duras aisladas de frutales colombianos y de dos levaduras comerciales, y sus efectos sobre las variaciones en la morfometría de vellosidades intestinales y productos de la microflora del ciego de pollos de engorde. Los pollos se distribuyeron al azar en 6 tratamientos: (tres diferentes cepas de levaduras nativas, dos controles con levaduras comerciales (Levapan®presentación seca y aB vista® y un control sin levadura. Los datos se analizaron usando el procedimiento GLM de sas versión 9 (sasinst., inc. Cary. n. C., se realizaron compara-ciones de los promedios utilizando la prueba de Tukey (P<0,05. se observaron diferencias estimadas significativas a favor de los pollos de engorde que recibieron las dietas con le-vaduras en el contenido cecal de ácidos grasos volátiles (propiónico e isobutírico de 0,13 mmol/ml y 0,03 mmol/ml, respectivamente, a los 8 días de edad de los pollos, y de 0,64 mmol/ml y 0,08 mmol/ml, respectivamente, a los 22 días de edad. a los 22 días de edad se encontraron diferencias entre el tratamiento control y los tratamientos con levaduras; el control presentó criptas más profundas en el duodeno y una relación menor altura de la vellosidad/profundidad de la cripta en el yeyuno. Los efectos tróficos positivos sobre la mucosa digestiva asociados al uso de levaduras en la alimentación de pollos de engorde, observados en esta investigación, confieren a estas un gran potencial nutricional y sugieren posteriores estudios que abarquen el ciclo completo de producción, involucrando otros factores relacionados con la capacidad de absorción de nutrientes

  13. Etude théorique des cellules solaires PV organiques: structure réseau interpénétré polymère conjugué-fullerène et cellules Graetzel

    OpenAIRE

    Zakaria, BOUZID

    2014-01-01

    Le photovoltaïque est aujourd'hui une technologie d'énergie renouvelable en plein essor. La croissance du marché a été comprise entre 15% et 20% durant la dernière décennie. Malgré le développement des matériaux et des méthodes de fabrication fortement soutenus par la croissance de l'industrie des semi-conducteurs, le coût des cellules solaires est resté élevé. Cependant, de nouveaux matériaux photovoltaïques ont été développés durant les dernières années, cela pourrait bien ouvri...

  14. Early Differential Diagnosis of Rhino-Orbito-Cerebral Mucormycosis and Bacterial Orbital Cellulitis: Based on Computed Tomography Findings

    Science.gov (United States)

    Son, Jun Hyuk; Lim, Hyung Bin; Lee, Soo Hyun; Yang, Jae Wook; Lee, Sung Bok

    2016-01-01

    Purpose To identify significant clinical and radiological findings that distinguish rhino-orbito-cerebral mucormycosis (ROCM) from bacterial orbital cellulitis (BOC). Methods This study was retrospective, multicenter, case-control study that enrolled 34 cases; 14 cases were diagnosed with ROCM and 20 cases were diagnosed with BOC at three different tertiary hospitals between 2005 and 2013. The medical records of all 34 cases were reviewed. The initial clinical manifestations (eyelid swelling, ptosis, extraocular muscle [EOM] limitation, conjunctival injection, and chemosis) and computed tomography (CT) findings (sinus mucosal thickening, full opacification, and air-fluid level) of both diseases were compared. Results Patients with diabetes mellitus (DM) and hypertension (HTN) showed higher incidence rates of ROCM than BOC (DM: p < 0.001, HTN: p = 0.036). ROCM cases exhibited more frequent EOM limitation than cases with BOC (100.0% vs. 66.7%, p = 0.024) but less frequent eyelid swelling (35.7% vs. 90.0%, p = 0.002). However, the incidence rates of ptosis, conjunctival injection, and chemosis exhibited no differences between the diseases. Abnormal CT findings were observed in the sinuses of all patients with ROCM, whereas 12 patients with BOC had sinus abnormalities (100.0% vs. 60.0%, p = 0.011). Thickening of the sinus mucosa was more frequent in patients with ROCM than in those with BOC (92.9% vs. 45.0%, p = 0.009). No significant differences in full opacification or air-fluid level were detected between the groups. Conclusions The differential diagnosis of ROCM and BOC is difficult. Nevertheless, physicians should consider ROCM when a patient with suspected orbital cellulitis presents with EOM limitation without swollen eyelids or thickening of the sinus mucosa on a CT scan. PMID:27501044

  15. CF findings of bowel infarction in 56 surgical patients, 5 of whom with reversible ischemia; Aspetti alla tomografia computerizzata dell'infarto intestinale. 56 pazienti sottoposti a interventi chirurgico di cui 5 con ischemia mesenterica reversibile.

    Energy Technology Data Exchange (ETDEWEB)

    Salzano, A.; De Rosa, A.; Carbone, M.; Ginolfi, F.; Rossi, E.; Amodio, F. [Naples Univ. Federico 2. (Italy). Ist. di Scienze Radiologiche; Muto, M.; Tuccillo, M. [Azienda Sanitaria di Rilievo Nazionale A. Cardarelli, Naples (Italy). Servizio di Neuroradiologia

    1999-04-01

    Bowel infarction is a rare and typical condition of the elderly; despite improvements in diagnostic imaging and vascular surgery, bowel infarction remains a major cause of acute abdomen, with mortality rates ranging 70-80%. Diagnosis on often late because clinical signs, laboratory data and radiologic findings are a specific. The authors investigated radiographic and particular CT patterns of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. CT is more sensitive than radiography and does not exhibit the limitations of angiography (i.e., invasiveness, radiation exposure and complex organization). Therefore CT can presently be considered the method of choice in patients with suspected bowel infarction. [Italian] L'infarto intestinale rappresenta una malattia rara e tipica del soggeto anziano; nonostante il notevole perfezionamento delle tecniche di diagnostica per immagini e il progresso della chirurgia vascolare, rimane ancora oggi una delle piu' temibili condizioni di addome acuto, con mortalita' superiore al 70-80%. Il riconoscimento diagnostico e' tardivo per l'aspecificita' dei dati di laboratorio, dei segni clinici e degli esami radiologici. La TC presenta maggiore afficacia diagnostica rispetto all'esame radiografico diretto e non ha limiti che caratterizzano l'angiografia, quali l'invasivita', radioesposizione e complessita' organizzativa: attualmente la metodica TC puo' essere indicata come indagine di scelta in pazienti con sospetto infarto intestinale.

  16. Intestinal preparation for colon enema with fosfo-soda fleet versus the conventional method; Preparazione intestinale per clisma del colon mediante fosfo-soda fleet: studio comparativo con il sistema tradizionale

    Energy Technology Data Exchange (ETDEWEB)

    Vecchioli Caldazza, A.; Celi, G.; De Franco, A.; Parrella, A.; Minordi, L.M.; Marano, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di radiologia

    1999-05-01

    The authors evaluate the possible optimization of a well-tolerated and versatile method of intestinal preparation able to adequately free the lumen and consequently improve diagnostic results with a lower risk of prolonged hospital stay for incorrectly prepared patients. They examined 40 patients, namely 20 men and 20 women referred to the Institute of radiology of the 'Sacro Cuore' Catholic University of Rome (Italy), Gastrointestinal tract unit, to undergo double contrast colonic enema. The statistical analysis of all data was performed with Wilcoxon test. Intestinal preparation with fosfo-soda fleet appeared to be definitely better than the conventional method relative to tolerance, while providing similarly satisfactory data relative to the other parameters. [Italian] Lo studio si propone di valutare la possibilita' di ottimizzare una tecnica di preparazione intestinale estremamente tollerabile e versatile che permetta di ottenere l'adeguata liberazione del lume del contenuto con conseguente miglioramento del risultato diagnostico e riduzione del rischio del prolungamento della durata dell'ospedalizzazione dei pazienti non idoneamente preparati. Sono stati valuati 40 pazienti, 20 maschi e 20 femmine, afferenti alla struttura dell'Istituto di radiologia dell'Universita' Cattolica del Sacro Cuore-Unita' apparato gastrointestinale, per essere sottoposti a clisma del colon con doppio mdc. Tutti i dati sono stati valutati statisticamente mediante test di Wilcoxon. La preparazione intestinale effettuata somministrando fosfo-soda fleet si e' dimostrata superiore rispetto a quella tradizionale per la variabile tollerabilita', fornendo contemporaneamente dati sovrapponibili a quelli del sistema tradizionale, soddisfacenti in assoluto, riguardo agli altri parametri esaminati.

  17. Tratamiento cognitivo-conductual protocolizado en grupo de las enfermedades inflamatorias intestinales Protocolized cognitive-behavioural group therapy for inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    M. A. Díaz Sibaja

    2007-10-01

    Full Text Available Introducción: los pacientes con enfermedades inflamatorias intestinales presentan una mayor tasa de alteraciones psicopatológicas que la población normal, predominantemente ansiedad y depresión. Objetivo: el principal objetivo de este estudio fue diseñar, poner en práctica y validar un programa de tratamiento psicológico protocolizado, basado en el modelo de competencias y con una metodología psicoeducativa, en el que se incluyeron los siguientes módulos de intervención: información de la enfermedad, modelo de afrontamiento, solución de problemas, técnicas de relajación, entrenamiento en habilidades sociales, técnicas de distracción y técnicas de reestructuración cognitiva. Todas estás técnicas fueron adaptadas a la problemática característica de la enfermedad inflamatoria intestinal. Método: la muestra estuvo constituida por 57 pacientes diagnosticados de enfermedad inflamatoria intestinal de la Asociación de Enfermos de Crohn y Colitis Ulcerosa de España. La muestra se distribuyó aleatoriamente en dos grupos experimentales, 33 formaron parte del programa de tratamiento en grupo y 24 fueron asignados al grupo control en lista de espera. Las variables emocionales medidas fueron: ansiedad y depresión. Resultados: los resultados reflejaron una mejoría clínica y estadísticamente significativa en las variables de ansiedad (p Introduction: patients affected by inflammatory bowel disease have a high rate of psychiatric disorders such as depression and anxiety. Objective: the main goal of this study was to design, to put into practice, and to validate a protocolized psychological treatment program based on the coping model, and a psycho-educational methodology in which the following intervention modules were included- illness information, coping model, problem solving techniques, relaxation, social skill training, distraction, and cognitive restructuring techniques. All these techniques were adapted to the characteristic

  18. Absorption intestinale des vitamines liposolubles

    OpenAIRE

    Reboul Emmanuelle

    2011-01-01

    The molecular mechanisms of fat-soluble vitamin intestinal absorption remain partly unknown, despite the fact that a better understanding of this process would certainly allow to improve their bioavailability. If their digestion-absorption process follows the fate of lipids globally, the recent discovery of membranes proteins involved in their absorption questioned the established dogmas. These new data should be taken into account to avoid dietary or drug interactions that may limit some fat...

  19. Absorption intestinale des vitamines liposolubles

    Directory of Open Access Journals (Sweden)

    Reboul Emmanuelle

    2011-03-01

    Full Text Available The molecular mechanisms of fat-soluble vitamin intestinal absorption remain partly unknown, despite the fact that a better understanding of this process would certainly allow to improve their bioavailability. If their digestion-absorption process follows the fate of lipids globally, the recent discovery of membranes proteins involved in their absorption questioned the established dogmas. These new data should be taken into account to avoid dietary or drug interactions that may limit some fatsoluble vitamin bioavailability.

  20. Cancer bronchique à petites cellules et grossesse: à propos d'un cas avec revue de la literature

    Science.gov (United States)

    Safini, Fatima; Jjouhadi, Hassan; Chehal, Asmaa; Mernissi, Farida; Wilfried, Akpoo; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2016-01-01

    Le cancer broncho-pulmonaire (CBP) de la femme enceinte est une entité rare, d’évolution péjorative. Cette situation devient de plus en plus fréquente, du fait de l'augmentation du tabagisme chez la femme. La transmission tumorale trans-placentaire avec atteinte fœtale est décrite surtout chez les femmes non traitées. Le traitement est multidisciplinaire et n'est pas bien codifié. Nous rapportons le cas d'une patiente de 23 ans chez qui le diagnostic d'un carcinome bronchique à petites cellules a été fait au cours de sa grossesse. Elle avait bénéficié d'une chimiothérapie pendant la grossesse, bien tolérée. L’évaluation radiologique a objectivé une stabilisation du processus pulmonaire. Le traitement a été complété par une association radio-chimiothérapie concomitante après l'accouchement. PMID:27279957

  1. Nasal Type Extranodal Natural Killer/T (NK/T) Cell Lymphoma Presenting as Periorbital Cellulitis: A Case Report

    Science.gov (United States)

    Shawabkeh, Ma’in Ali Al; Sulaiti, Mansour Al; Sa’ey, Hamad Al; Ganesan, Shanmugam

    2016-01-01

    Patient: Male, 25 Final Diagnosis: Nasal type • extra nodal NK/T-cell lymphoma Symptoms: Left periorbital swelling • redness • pain for 25 days • yellowish eye discharge associated • headache • fever Medication: — Clinical Procedure: — Specialty: Otolaryngology Objective: Unusual clinical course Background: Extranodal lymphoma of the paranasal sinuses is a rare clinical entity seen in only 5–8% of extranodal lymphomas of the head and neck. Nasal natural killer/T cell lymphoma (Nasal NKTCL), which is a subtype of peripheral T cell lymphoma, constitutes about 1.4% of all lymphomas. NKTCL is usually diagnosed at a late stage because it presents with nonspecific symptoms in the early stages. Case Report: We report the case of a 25-year-old male patient who presented with periorbital swelling treated as fungal sinusitis but proven to have NKTCL. We review the literature and discuss the clinical manifestations of the disease, its relation to EBV virus, the histological and radiological characteristics, the prognostic indicators, and treatment options. This case report shows physicians that NKTCL lymphoma can present as periorbital cellulitis, although few similar cases are found in the literature. Conclusions: NKTCL is a destructive midline tumor that should be kept in mind as a differential diagnosis of paranasal sinus lesions to help in early diagnosis, which can improve the prognosis. PMID:27932776

  2. Analysis of sixty-three cases of orbital cellulitis%眶蜂窝织炎63例分析

    Institute of Scientific and Technical Information of China (English)

    杜军辉; 王雨生; 李夏; 郭长梅; 李曼红

    2010-01-01

    目的 探讨眶蜂窝织炎的致病原因、致病菌及并发症.方法 回顾性病例系列研究.回顾性分析西京医院自1960年至2008年收治的63例眶蜂窝织炎住院患者的临床资料,对其性别、年龄、致病途径、致病菌及并发症进行分析.结果 63例患者中,男性48例(76.2%),女性15例(23.8%);10岁以下年龄组患者较多(22例,34.9%);单眼发病多见(61例,96.8%);32例(50.8%)患者伴有明显眼球突出.致病途径以周围组织炎症蔓延最多见(47.6%),其他包括血行感染(19.0%)、眼部外伤(15.9%)和眼部手术后并发感染(3.2%).30例患者进行了细菌培养,仅18例(60.0%)细菌培养为阳性.致病菌有4类,以葡萄球菌属最为多见(14例,77.8%),尤以金黄色葡萄球菌为主(8例,44.4%),此外还有绿脓杆菌(11.1%)、甲型溶血性链球菌(5.6%)和中间型弗氏枸橼酸杆菌(5.6%).本组有19例(30.1%)发生并发症,包括败血症(12.7%)、暴露性角膜炎(4.8%)、全眼球炎(4.8%)、化脓性脑膜炎(4.8%)和海绵窦栓塞性静脉炎(3.2%)等.结论 眶蜂窝织炎多见于10岁以下儿童患者,以单眼眼球突出为主要表现,致病途径以眶周组织结构感染蔓延为主.细菌培养阳性率较低,以金黄色葡萄球菌为主要致病菌.本病可发生严重并发症,宜早期积极给予广谱抗生素治疗,如脓肿形成应及时切开引流.%Objective To investigate the clinical characteristics, etiological factors and pathogenic bacterium of orbital cellulitis. Methods A retrospective clinical study was done on 63 orbital cellulitis patients receiving treatments in Xijing Hospital between 1960 to 2008, and their gender, age, pathogenic approach, pathogens and complications were analyzed. Results Of the 63 patients, 76.2% were males and 23.8% were females. The highest incidence occurred in the 0-10 year old group (34.9%). There were 96.8% of the patients suffered unilateral eye injures, 50.8% of the patients expressed obvious exophthalmos

  3. Intestinal parasitoses and environmental factors in a rural population of Argentina, 2002-2003 Parasitosis intestinales y factores ambientales en una población rural de Argentina, 2002-2003

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    Juan A. Basualdo

    2007-08-01

    Full Text Available We evaluate the prevalence of intestinal parasites in 504 people and the degree of association between environmental variables and parasites found in population, soil and water in a rural area of Argentina during 2002-2003. A structured survey was used to evaluate the environmental variables and fecal-human, soil and water samples were analyzed. The prevalence of parasites was 45.4%. Most prevalent protozoa were Blastocystis hominis (27.2% and Giardia lamblia (6.9%, while the most prevalent helminth was Ascaris lumbricoides (3.8%. The analyzed environmental variables showing association (p Hemos evaluado la prevalencia de parásitos intestinales en 504 personas y el grado de asociación entre las variables ambientales y los parásitos intestinales hallados en la población, el suelo y el agua de una zona rural de Argentina durante 2002-2003. Se utilizó una encuesta estructurada para relevar las variables ambientales y se examinaron muestras fecales humanas, de agua y de suelo. La prevalencia parasitaria fue de 45,4%. Los protozoos prevalentes fueron Blastocystis hominis (27,2% y Giardia lamblia (6,9%, mientras que el helminto mas prevalente fue Ascaris lumbricoides (3,8%. Las variables ambientales analizadas que mostraron asociación (p < 0,05 con la presencia de parásitos en la población fueron: casa de cartón-chapa o de madera con piso de tierra, bomba de agua domiciliaria o comunitaria, canilla fuera de la casa o pública y pozo ciego o letrina. Elementos parasitarios fueron hallados en el 82,3% de las muestras de suelo y en el 84,2% de las muestras de agua. En ambas muestras fueron hallados parásitos que también se encontraron en las personas. En este trabajo hemos hallado deficientes condiciones sanitarias asociadas con la presencia de parásitos en las personas y hemos evidenciado que el suelo y el agua contaminada fueron la fuente de esos parasitos.

  4. Quantification des cellules viables de P. phosphoreum dans les pavés de saumon cru par PCR temps reel

    DEFF Research Database (Denmark)

    Macé, Sabine; Mamlouk, Kelthoum; Chipchakova, Stoyka

    ’altération. Par conséquent, nous avons développé une méthode de PCR temps réel spécifique combinée avec une étape de traitement au PMA pour quantifier les cellules viable de P.phosphoreum dans le saumon cru conditionné sous atmosphère modifiée. Les amorces spécifiques ont été dessinées pour amplifier un fragment...... obtenue en comparaison avec des résultats de numération sur milieu Marine Agar. Sur saumons artificiellement contaminés, la quantification par PCR temps réel est linéaire sur 5 Log. Sur les produits naturellement contaminés, la méthode fonctionne avec succès avec un seuil minimum de 3 Log (UFC/g) pour une...... quantification précise. La précision de cette méthode a également été évaluée en la comparant avec une méthode déjà existence de quantification par conductancemétrie. Les données obtenues sur 22 échantillons montrent une très bonne corrélation (R2 de 0.94) entre les résultats des 2 méthodes. Ce travail a donné...

  5. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba Training for diagnosis of intestinal parasites in the national laboratory system in Cuba

    Directory of Open Access Journals (Sweden)

    Fidel Angel Núñez

    2001-06-01

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (pA national training project in the diagnosis of intestinal parasites was conducted in 1997. An initial national course was followed respectively by courses in the Central, Eastern, and Western Provinces. Our results showed that Cryptosporidium parvum, Cyclospora cayetanensis, and leukocytes showed a significantly lower percentage of errors after the training than before (p 0.05. Furthermore, when comparing scores before and after training, a significant increase in median scores appeared in the Central Provinces (p < 0.05, Western Provinces (p < 0.01, and in the entire series (p < 0.01. The results showed the effectiveness of this intervention; these periodic mandatory training courses should be developed together with national programs for quality assessment in Parasitology.

  6. Dissecting cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppurativa.

    Science.gov (United States)

    Scheinfeld, Noah

    2014-05-16

    Dissecting cellulitis (DC) also referred to as to as perifolliculitis capitis abscedens et suffodiens (Hoffman) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. In the U.S., it predominantly occurs in African American men between 20-40 years of age. DC also occurs in other races and women more rarely. DC has been reported worldwide. Older therapies reported effective include: low dose oral zinc, isotretinoin, minocycline, sulfa drugs, tetracycline, prednisone, intralesional triamcinolone, incision and drainage, dapsone, antiandrogens (in women), topical clindamycin, topical isotretinoin, X-ray epilation and ablation, ablative C02 lasers, hair removal lasers (800nm and 694nm), and surgical excision. Newer treatments reported include tumor necrosis factor blockers (TNFB), quinolones, macrolide antibiotics, rifampin, alitretinoin, metronidazole, and high dose zinc sulphate (135-220 mg TID). Isotretinoin seems to provide the best chance at remission, but the number of reports is small, dosing schedules variable, and the long term follow up beyond a year is negligible; treatment failures have been reported. TNFB can succeed when isotretinoin fails, either as monotherapy, or as a bridge to aggressive surgical treatment, but long term data is lacking. Non-medical therapies noted in the last decade include: the 1064 nm laser, ALA-PDT, and modern external beam radiation therapy. Studies that span more than 1 year are lacking. Newer pathologic hair findings include: pigmented casts, black dots, and "3D" yellow dots. Newer associations include: keratitis-ichthyosis-deafness syndrome, Crohn disease and pyoderma gangrenosum. Older associations include arthritis and keratitis. DC is likely a reaction pattern, as is shown by its varied therapeutic successes and failures. The etiology of DC remains enigmatic and DC is distinct from hidradenitis suppurativa, which is shown by their varied responses to therapies and their

  7. Primary cellulitis and cutaneous abscess caused by Yersinia enterocolitica in an immunocompetent host: A case report and literature review.

    Science.gov (United States)

    Kato, Hirofumi; Sasaki, Shugo; Sekiya, Noritaka

    2016-06-01

    Primary extraintestinal complications caused by Yersinia enterocolitica are extremely rare, especially in the form of skin and soft-tissue manifestations, and little is known about their clinical characteristics and treatments. We presented our case and reviewed past cases of primary skin and soft-tissue infections caused by Y enterocolitica. We report a case of primary cellulitis and cutaneous abscess caused by Y enterocolitica in an immunocompetent 70-year-old woman with keratodermia tylodes palmaris progressiva. She presented to an outpatient clinic with redness, swelling, and pain of the left ring finger and left upper arm without fever or gastrointestinal symptoms 3 days before admission. One day later, ulceration of the skin with exposed bone of the proximal interphalangeal joint of the left ring finger developed, and cefditoren pivoxil was described. However, she was admitted to our hospital due to deterioration of symptoms involving the left finger and upper arm. Cefazolin was initiated on admission, then changed to sulbactam/ampicillin and vancomycin with debridement of the left ring finger and drainage of the left upper arm abscess. Wound culture grew Y enterocolitica serotype O:8 and methicillin-sensitive Staphylococcus aureus. Blood cultures were negative and osteomyelitis was ruled out. Vancomycin was switched to ciprofloxacin, then skin and soft-tissue manifestations showed clear improvement within a few days. The patient received 14 days of ciprofloxacin and oral amoxicillin/clavulanate and has since shown no recurrence. We reviewed 12 cases of primary skin and soft-tissue infections caused by Y enterocolitica from the literature. In several past cases, portal entry involved failure of the skin barrier on distal body parts. Thereafter, infection might have spread to the regional lymph nodes from the ruptured skin. Y enterocolitica is typically resistant to aminopenicillins and narrow-spectrum cephalosporins. In most cases, these inefficient

  8. Perianal streptococcal cellulitis

    Science.gov (United States)

    Complications that may result include: Anal scarring, fistula , or abscess Bleeding, discharge Bloodstream or other streptococcal infections (including heart, joint, and bone) Kidney disease (acute glomerulonephritis ) Severe skin and soft tissue ...

  9. What Is Cellulitis?

    Science.gov (United States)

    ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ...

  10. Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

    Directory of Open Access Journals (Sweden)

    Ledina Dragan

    2012-11-01

    Full Text Available Abstract Introduction Campylobacter is an important causative agent of intestinal infections in humans. Bacteremia is detected in less than 1% of patients, mainly in immunocompromised patients and in extreme age groups. Cellulitis is a relatively common manifestation of Campylobacter infection, but concomitant bacteremia is a rare event. Infections of the pacemaker area are caused primarily by staphylococci, followed by fungi, streptococci and Gram-negative rods. To the best of our knowledge, this is the first case report of pacemaker pocket infection and bacteremia caused by Campylobacter fetus. Case presentation A 72-year-old Croatian Caucasian man with myelodysplasia, impaired fasting glucose levels and a recently implanted permanent pacemaker was admitted to hospital after six days of fever, development of red swelling of the pacemaker pocket area and worsening of his general condition. No antibiotic therapy was introduced in the outpatient setting. He denied any recent gastrointestinal disturbances. With the exception of an elevated leukocyte count, erythrocyte sedimentation rate, and C-reactive protein and blood glucose levels, other laboratory findings were normal. Treatment with vancomycin plus netilmicin was introduced, and a surgical incision with drainage of the pacemaker pocket was performed. The entire pacemaker system was removed and a new one re-implanted after 14 days of antibiotic therapy. Transesophageal echocardiography showed no pathological findings. Three subsequent blood cultures obtained on admission as well as swab culture of the incised pacemaker area revealed Campylobacter fetus; stool and pacemaker lead cultures were negative. According to the microbiological results, antibiotic therapy was changed to ciprofloxacin plus netilmicin. A clinical examination and the results of a laboratory analysis performed after two weeks of therapy were within normal limits. Conclusion Myelodysplasia, impaired fasting glucose levels

  11. Etude des phenomenes chimiques au contact entre le bloc cathodique et la barre collectrice d'une cellule d'electrolyse d'aluminium

    Science.gov (United States)

    Lebeuf, Martin

    La production d'aluminium est une industrie importante au Québec. Les propriétés de ce métal le vouent à de multiples usages présents et futurs dans le cadre d'une économie moderne durable. Toutefois, le procédé Hall-Héroult est très énergivore et des progrès demeurent donc nécessaires pour en diminuer les coûts financiers et environnementaux. Parmi les améliorations envisageables de la cellule d'électrolyse se trouve le contact entre la cathode et la barre collectrice, qui doit offrir une faible résistivité au passage du courant électrique. En cours d'opération de la cellule, ce contact a tendance à se dégrader, générant des pertes énergétiques significatives. Les causes de cette dégradation, pouvant provenir de phénomènes chimiques, thermiques, mécaniques et/ou électriques, demeurent mal comprises. Le but du présent projet était donc d'étudier les phénomènes chimiques se produisant au contact bloc-barre de la cellule d'électrolyse Hall-Héroult. En premier lieu, un aspect crucial à considérer est la pénétration du bain électrolytique dans la cathode, car des composés de bain atteignent éventuellement la barre collectrice et peuvent y réagir. A cet effet, une méthode novatrice a été développée afin d'étudier les cathodes et la pénétration du bain dans celles-ci à l'aide de la microtomographie à rayons X. Cette méthode rapide et efficace s'est avérée fort utile dans le projet et a un potentiel important pour l'étude future des cathodes et des phénomènes qui s'y produisent. Ensuite, une cellule d'électrolyse rectangulaire à petite échelle a été développée. Plusieurs phénomènes observés 'en industrie sur des autopsies de cellules post-opération et rapportés dans la littérature ont été reproduis avec succès à l'aide de cette cellule expérimentale. Puis, des tests sans électrolyse, ciblant l'effet du bain électrolytique sur l'acier, ont aussi été conçus et complétés afin de s

  12. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales Intestinal parasitosis in Mbyá-Guaraní populations from Misiones Province, Argentina: epidemiological and nutritional aspects

    Directory of Open Access Journals (Sweden)

    Graciela Teresa Navone

    2006-05-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p Intestinal parasite infestation in indigenous Mbyá-Guaraní communities in Misiones, Argentina, was described and associated with nutritional status and environmental and cultural factors. The results were compared with those from Takuapí, a neighboring indigenous population, and the nearest urban population, Aristóbulo del Valle. The Ritchie, Willis, and Kato Katz techniques were used to analyze the stool samples. Anthropometric parameters were analyzed and earth samples processed. From a total sample of 296 individuals analyzed in the four populations, 100 (87.7%, 63 (88.7%, 49 (96.1%, and 50 (82% were infested in Kaaguy Poty, Yvy Pytá, Takuapí, and Aristóbulo del Valle, respectively. 84% of infested individuals had multiple parasites. The 43% of the individuals presented malnutrition, and 87% of these were infested. There was an association between use of latrines and Giardia lamblia (p < 0

  13. Prediction of Instability for Miscible Displacements in a Hele-Shaw Cell Prévision de l'instabilité pour des déplacements miscibles dans une cellule Hele-Shaw

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    Coskuner G.

    2006-11-01

    Full Text Available A universal dimensionless scaling group and its critical value at the onset of instability for a miscible displacement in a Hele-Shaw cell is derived. The derivation is based on a variational technique and it is capable of considering, for the first time, the effect of the length of a Hele-Shaw cell on the criterion for the onset of instability. The theory is verified by comparing it with forty-four Hele-Shaw cell experiments. On calcule un groupe universel sans dimension de mise à l'échelle et sa valeur critique au départ de l'instabilité dans un déplacement miscible dans une cellule Hele-Shaw. Ce calcul est basé sur une technique variationnelle et permet, pour la première fois, de prendre en compte l'effet de la longueur d'une cellule Hele-Shaw sur le critère d'apparition d'instabilité. La théorie est vérifiée en la comparant avec des expériences réalisées avec quarante-quatre cellules Hele-Shaw.

  14. Prevalencia de parásitos intestinales en manipuladores de alimentos en una comunidad rural de Cojedes, Venezuela Prevalence of intestinal parasites in food handlers in a rural community in Cojedes, Venezuela

    Directory of Open Access Journals (Sweden)

    Gilberto Bastidas

    2012-12-01

    Full Text Available Introducción: las parasitosis intestinales constituyen un problema de salud pública, por la elevada prevalencia que muestran, donde los manipuladores de alimentos parasitados, se convierten en potenciales fuentes de infección, pues algunas formas parasitarias se transmiten directamente de la fuente de infección al susceptible, por vía fecal-oral. A esto se suma el incremento en el consumo de comida fuera del núcleo familiar, en residentes de zonas urbanas y rurales. El objeto es recolectar información para que las autoridades sanitarias implementen programas de salud acordes a cada región. Métodos: estudio descriptivo, de campo y transversal. Fueron 64 los manipuladores de alimentos, pero la muestra fue de 50. Se aplicó un cuestionario sobre prácticas higiénicas en la manipulación de alimentos, se determinó nivel socioeconómico y prevalencia de parasitosis por ensayos coproparasitológicos. Resultados: fueron 44 mujeres y 6 hombres; un 52% pertenecía al estrato IV; la mayoría conocía las prácticas higiénicas en la manipulación de alimentos, pero un 26% tenía alguna parasitosis intestinal; los parásitos más frecuentes fueron: E. nana (41,2% y B. hominis (38,7%; el monoparasitismo fue del 54%. Conclusión: en la presencia y frecuencia de una enfermedad parasitaria intestinal intervienen diversos factores. Por lo tanto, en manipuladores de alimentos, la educación ajustada al entorno, en buenas prácticas de higiene, es básica para prevenir la transmisión.Aim: Intestinal parasites are a public health problem due to their high prevalence. Handlers of food contaminated with parasites become potential sources of infection because some parasitic forms are transmitted directly from the source of infection to the host through the fecal-oral route. In addition, there is an increased consumption of food outside the household by residents of urban and rural areas. The objective is to collect information so that health authorities

  15. Régulation de la production, par des cellules endothéliales, de cytokines pro-inflammatoires après irradiation

    Science.gov (United States)

    van der Meeren, A.; Lafont, H.; Mathé, D.

    1998-04-01

    Gamma irradiation leads to an increased production of interleukin- (IL)-6 and IL-8 by human endothelial cells. In order to regulate the radio-induced production of these pro-inflammatory cytokines, we used the immunoregulatory cytokines IL-4 and IL-10. These agents were added either before or after a 10 Gy-irradiation. Our results show that it is possible to decrease the radio-induced production of IL-6 and IL-8 with the use of IL-4 and IL-10. Differences in the intensity of the response have been observed according to the time of treatment. The anti-inflammatory potential of both IL-4 and IL-10 was more pronounced when added after irradiation. Après irradiation gamma, des cellules endothéliales humaines ont une production accrue des interleukines (IL-) -6 et -8. Dans le but de réguler la production de ces cytokines pro-inflammatoires, nous avons utilisé des cytokines dites anti-inflammatoires, l'IL-4 et l'IL-10. Ces agents ont été ajoutés soit avant soit après une irradiation de 10Gy. Nos résultats montrent qu'il est possible de diminuer les productions radio-induites d'IL-6 et d'IL-8 par l'IL-4 et l'IL-10. Des différences dans l'intensité de la réponse ont toutefois été observées selon que l'IL-4 ou l'IL-10 ont été ajoutées avant ou après irradiation; leur efficacité anti-inflammatoire étant plus marquée lorsque les cytokines sont ajoutées après l'irradiation.

  16. Oral and Maxillofacial Infection Misdiagnosed as Facial Cellulitis:Report of 1 Cases%口腔颌面部感染误诊为鼻面部蜂窝组织炎1例

    Institute of Scientific and Technical Information of China (English)

    王爱平; 孙海波

    2014-01-01

    本文通过鼻面部肿痛应为左上颌中切牙急性化脓性尖周炎引起的眶下间隙急性化脓性感染的病例对口腔颌面部感染误诊为鼻面部蜂窝组织炎的病例进行阐述。%The cases of acute suppurative infection clearance through nasal and facial swel ing caused by left maxil ary central incisors should for acute suppurative periapical infection infraorbital carries on the elaboration to the oral and maxil ofacial infection misdiagnosed as facial cellulitis case.

  17. Glycosphingolipides et fusion virus-cellule : données actuelles montrant le rôle des micro-domaines membranaires dans le cycle d’infection du VIH-1

    Directory of Open Access Journals (Sweden)

    Hammache Djilali

    2000-09-01

    Full Text Available Depuis plusieurs années, nous étudions les mécanismes moléculaires responsables de la fusion du virus de l’immunodéficience humaine (VIH avec la membrane plasmique des cellules cibles. Ces travaux ont permis de préciser le rôle essentiel joué par les micro-domaines de glycosphingolipides au cours de la fusion virus-cellule. En particulier, nous avons pu reconstituer un complexe de fusion fonctionnel faisant intervenir les différents partenaires moléculaires de la fusion : un micro-domaine de glycosphingolipide se présentant sous la forme d’un film monomoléculaire à l’interface eau-air, le récepteur CD4 et la glycoprotéine externe de l’enveloppe du virus, la gp120. La dynamique des interactions moléculaires dans ce complexe de fusion a pu être mesurée à l’aide d’un micro-tensiomètre. Ce système expérimental pourrait permettre d’évaluer l’activité d’inhibiteurs de fusion tels que des analogues synthétiques de glycosphingolipides.

  18. 口腔颌面部蜂窝织炎临床特点及治疗探讨%Clinical characteristics and investigation of treatment of oral and maxillofacial cellulitis

    Institute of Scientific and Technical Information of China (English)

    赵琼

    2014-01-01

    Objective:To explore the clinical characteristics and treatment of oral and maxillofacial cellulitis.Methods:50 patients with oral and maxillofacial cellulitis were selected.We developed a standard treatment plan for each patient according to the characteristics.Results:In 50 patients of this group,49 cases(98%) were cured,1 case was invalid and transferred to other hospital. The average course of disease was 15.8±2.1 days;among them,the course of disease of patients complicated with diabetic patients was relatively longer,some were more than one month.Conclusion:Early attention and diagnosis and treatment,anti-infection,local incision drainage and operation according to the clinical characteristics of oral and maxillofacial cellulitis,can significantly improve the prognosis,and it is very important to improve the quality of life of patients.%目的:探讨口腔颌面部蜂窝织炎临床特点及治疗。方法:收治口腔颌面部蜂窝织炎患者50例作为研究对象,依据临床特点,制定规范方案治疗。结果:本组50例患者,治愈49例(98%),无效转院1例,平均病程(15.8±2.1)天,其中有糖尿病合并者病程相对较长,部分超过1个月。结论:针对口腔颌面部蜂窝织炎,依据临床特点,早重视及诊治,行抗感染、局部切开引流及手术等,可明显改善预后,对提高患者生存质量有非常重要的意义。

  19. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    Directory of Open Access Journals (Sweden)

    César Moreira Sampaio

    2001-06-01

    Full Text Available Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecções, na grande maioria, tiveram localização pré-septal (94,2%. As hemoculturas, realizadas em 21 pacientes, resultaram em 71% de negatividade, seguido por positividade para S. aureus (19%, H. influenzae (4,7% e flora mista (4,7%. Todos os pacientes foram tratados e curados com antibioticoterapia utilizando 16 quimioterápicos em 25 diferentes esquemas terapêuticos. A drenagem cirúrgica foi realizada em apenas 7 pacientes. Conclusão: A despeito da falta de uniformidade e diversidade de esquemas terapêuticos empregados nos casos estudados e da falta de avaliação oftalmológica na maioria dos casos, os pacientes foram curados sem complicações. Tal fato indica a necessidade de estudos prospectivos que visem a elaboração de protocolo terapêutico para as celulites da região orbitária na infância, que leve em consideração a relação custo-benefício positiva.Purpose: Retrospective study of clinical and therapeutic aspects in children with orbital and preseptal cellulitis. Methods: Fifty-two records of patients admitted at the São Rafael Hospital between 1990 and 1998 were reviewed. The age of the patients ranged from one month to twelve years. Based on a protocol elaborated by the authors the following aspects were analyzed: age, sex, predisposing factors, localization of the cellulitis in the orbital region, clinical, laboratorial and image findings as well as the clinical or surgical therapy and the occurrence of complications

  20. Clinical analysis of endoscopic surgery for rhinogenous orbital cellulitis%鼻源性眶蜂窝织炎鼻内镜手术治疗临床研究

    Institute of Scientific and Technical Information of China (English)

    周昆; 刘玥; 王佳; 贾明辉

    2015-01-01

    目的 探讨鼻内镜在鼻窦源性眶蜂窝织炎治疗中的应用效果.方法 鼻窦源性眶蜂窝织炎14例.将继发于上呼吸道感染的急性鼻窦炎归于急性组(9例),将慢性鼻窦炎急性发作归于慢性组(5例).两组患者均进行经鼻窦的鼻内镜下手术,观察其疗效.结果 经鼻内镜下手术及敏感抗生素应用等综合治疗,两组患者均痊愈,未发现严重影响视力及全身健康的并发症.结论 鼻内镜下手术治疗鼻窦源性眶蜂窝织炎具有视野清晰、径路便利、损伤小、恢复快及无面部瘢痕等优势.%Objective To evaluate the clinical effect of endoscopic surgery for the treatment of rhinogenous orbital cellulitis.Methods Fourteen cases of rhinogenous orbital cellulitis were treated by endoscopic surgery via nasal sinus.The curative effect of the surgery and postoperative complications were recorded and analyzed.Results After endoscopic surgery combined with systemic antibiotics,all patients were cured and no serious complication was observed.Conclusion Compared with the traditional surgery,endoscopic surgery possessed more advantages for the treatment of rhinogenous orbital cellalitis,such as clear field,convenient surgical route,less bleeding,no facial scar,quick recovery and good effect.

  1. Contribution to the radiological study of the eosinophilic granuloma of the mandible (Unifocal granuloma due to Langherans' cell histiocytosis); Contributo allo studio radiologico del granuloma eosinofilo della mandibola (granuloma unifocale da istiocitosi delle cellule di Lagherhans)

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    Chigi, Gino; Pastremoli, Alessandro; Pisi, Paolo; Pastremoli, Alfredo [Bologna Univ., Bologna (Italy). Dipartimento di scienze odontomastologiche; Bianchi, Giuseppe [Istituti Ortopedici Rizzoli, Bologna (Italy)

    2005-04-01

    non completamente risolto per talune condizioni patologiche, nelle quali i dati obiettivi ed anamnestici sono relativamente uniformi e il quadro radiologico privo di qualsiasi caratteristica. Materiale e metodi: Il materiale � costituito da sei casi di istiocitosi delle cellule di Langherans della mandibola osservati nell'arco di un decennio. Lo studio � basato sulla valutazione della documentazione radiologica tradizionale. Le radiografie sono state eseguite in proiezione latero-laterale-obliqua che, come noto, libera quasi completamente la porzione orizzontale della mandibola dalla sovrapposizione delle immagini di altre strutture ossee. Risultati: I risultati delle indagini radiologiche sono riportati nella tabella I. Si tratta di reticoloendoteliopatie capaci di dar luogo ad un processo granulomatoso costituito da polinucleati eosinofili, plasmacellule e linfociti e, fondamentalmente, da grandi cellule istiocitarie mononucleate dotate di attivit� granulopessica e fagocitaria, spiccatamente proliferanti nel tessuto osseo, identificabili con le cellule di Langherhans della pelle, delle mucose, degli spazi periodontali, del midollo osseo. Il tessuto granulomatoso che ne deriva si infiltra tra gli elementi costitutivi dell'organo colpito ed estendendosi comprime, atrofizza e tende a distruggere il tessuto, sostituendosi ad esso. Le alterazioni determinate dal granuloma isiocitario di Langherhans prevalgono nettamente nel sistema scheletrico e si verificano, in ordine di frequenza, nel cranio, nelle ossa lunghe dell'estremit�, nel piede, nelle coste e nella colonna vertebrale. L'interessamento della mucosa orale � eccezionale. Conclusioni: Nel granuloma istiocitario unifocale di Langherhans della mandibola l'indagine radiologica � indispensabile per l'approccio allo studio della tumefazione premandibolare fermo restando che la diagnosi di natura si basa esclusivamente sulla biopsia. Oltre all'esame radiologico digitale o

  2. Case anglysis for a patient with post-operative orbital cellulitis and endophthalmitis%1例白内障术后眼眶蜂窝织炎合并眼内炎患者的病例分析

    Institute of Scientific and Technical Information of China (English)

    韩芙蓉; 刘妍; 赵环宇; 李荔

    2015-01-01

    Objective:To analyze the common pathogenic bacteria of endophthalmitis and the selection of anti-infective drugs. Methods: According to the guidelines and patients' condition, the pharmaceutical care conducted by clinical pharmacist on a patient with post-operative orbital cellulitis and endophthalmitis was analyzed.Results:Clinical pharmacist can provide pharmaceutical care in the aspects of dose adjustment, blood concentration monitoring and adverse effects. Conclusion:Clinical pharmacist can take part in the clinical treatment so as to ensure the safet, effective, economic and suitable application of medications.%目的: 分析白内障术后眼内炎的常见致病菌以及抗感染药物的选择.方法:根据指南,结合患者病情,分析临床药师参与1例白内障术后眼内炎患者的药学监护点.结果:临床药师可以从药物剂量调整、血药浓度监测、不良反应监测等方面对患者进行药学监护.结论:临床药师参与临床治疗实践,有利于更好地保障患者用药的安全、有效、经济、适宜.

  3. 口底重症多间隙感染41例患者诊治的回顾性分析%Treatment of severe cellulitis of the mouth floor:A retrospective study of 41 cases

    Institute of Scientific and Technical Information of China (English)

    乔波; 张浚睿; 陆斌; 孔亮; 刘芳; 封兴华

    2015-01-01

    目的:回顾性分析41例口底重症多间隙感染患者的临床诊治资料。方法:对患者性别、年龄、流行病学特征、感染的诱因、症状、初步诊断、重要伴发疾病、合并症、临床诊断、抗生素的使用(种类及疗程)、手术干预及转归等方面进行总结及系统性分析。结果:男女比例为2.4∶1,年龄10~93岁(平均46.23岁),农村城市比例为3∶1。14.6%患者初步诊断不准确。31%患者在发病后5 d 内就诊。82.9%患者为牙源性感染,35%患者初诊时炎症已扩散至咽旁间隙、翼下颌间隙或者合并颈部感染,7.5%患者感染扩散至纵膈;2例患者入院后已合并严重纵膈及肺部感染,转呼吸内科治疗,1例因肾衰转泌尿外科治疗;38例患者入院后及时给予静脉滴注抗生素抗感染治疗、尽早完成切开引流,痊愈出院,平均住院21 d。结论:牙源性感染的重症口底多间隙感染最多见,其治疗的关键在于早期诊断,维持呼吸道通畅,选择合适的抗生素,尽早切开引流、综合治疗去除病因。%Objective:To analyze clinical data of 41 patients with severe mouth floor cellulitis.Methods:Patient's gender,age, epidemiological characteristics,origin of inflammation,symptoms of the disease,primary diagnosis,concomitant diseases,complica-tions,clinical diagnosis,the use of antibiotics (type and course),operation and outcomes were reviewed.Results:The male-fe-male ratio of the patients was 2.4∶1 .Age distribution was 1 0 -93 years old(with the mean of 46.23).The cases from urban-rural area was 3∶1 ,1 4.6% of the patients'primary diagnosis was not accurate.Only 31 % of the patients went to doctors in the first 5 days from the beginning of the disease.82.9% of the mouth floor cellulites were odontogenic.35% of the cases were diagnosed to be in-fectious diffusion to parapharyngeal,pterygomandibular spaces or to be complicating with neck

  4. Efectos de la desnutrición sobre la colagenización de anastomosis intestinales: análisis de procolágeno y telopéptido carboxiterminal mediante radioinmunoanálisis Role of malnutrition in intestinal anastomosis collagenization: an analysis of procollagen (PINP and carboxyterminal telopeptide (ICTP by radioimmunoassay

    Directory of Open Access Journals (Sweden)

    J. M. Álamo

    2007-02-01

    Full Text Available Introducción: diversos factores influyen en la cicatrización correcta de las suturas intestinales tras la práctica de una resección intestinal. Uno de los factores más implicados es el estado nutricional del paciente. Objetivos: evaluar la influencia de la desnutrición inducida sobre la viabilidad de una anastomosis intestinal primaria mediante el análisis del procolágeno (PINP como marcador de la síntesis de colágeno I, y del telopéptido carboxiterminal del colágeno I (ICTP como marcador de la destrucción del mismo. Métodos: 40 ratas Wistar y material de radioinmunoensayo. Métodos: diseñamos 2 grupos de ratas, 20 animales por cada grupo: grupo control (A y grupo "desnutrición" (B. Se analiza PINP e ICTP mediante RIA sobre tejido colónico homogeneizado, preanastomótico y anastomótico. Resultados: existen unos niveles menores de PINP en el colon de las ratas del grupo B comparado con el colon del grupo A (0,3620 y 0,4340 µg/g respectivamente (p = 0,032. Hay un mayor nivel de ICTP analizado en el colon del grupo B (0,9545 en contraposición a 0,8460 µg/g en el grupo A (p = 0,875. En las anastomosis del grupo B existe una menor síntesis de PINP en comparación con el grupo A (0,376 y 0,468 µg/g respectivamente, p = 0,002. Conclusiones: la anastomosis colónica incrementa los niveles de PINP e ICTP en el tejido cicatricial (p = 0,000; la malnutrición reduce la colagenización de las anastomosis (p = 0,000.Introduction: some clinical, anatomo-pathological, and technical factors influence the correct healing of intestinal suture following an intestinal resection. One of the most influential factors is patient nutritional status. Objectives: to evaluate the influence of malnutrition on the viability of primary intestinal anastomosis by the analysis of collagen I deposition. Methods: 40 Wistar rats, radioimmunoassay material. We used 2 groups of rats, 20 animals in each group: a control group (A and a "malnutrition" group (B

  5. Prevalência de parasitos intestinais na comunidade indígena Maxakali, Minas Gerais, Brasil, 2009 Prevalencia de parásitos intestinales en la comunidad indígena Maxakali, Minas Gerais, Brasil, 2009 Prevalence of intestinal parasites in the Maxakali indigenous community in Minas Gerais, Brazil, 2009

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    João Luiz Pena

    2013-04-01

    Full Text Available O objetivo deste estudo foi determinar a prevalência de parasitos intestinais na etnia Maxakali em Minas Gerais, Brasil. Os exames parasitológico das fezes foram realizados através da técnica TF-Test, sendo as amostras fecais coletadas em três dias alternados, em tubos independentes, contendo formol a 10%, unificados para dupla filtragem por centrifugação. Triplicatas de uma alíquota do sedimento foram examinadas em microscópio (10x e 40x para identificação de ovos, cistos e larvas. A prevalência de parasitos (89,5% e do poliparasitismo (46% foi semelhante quanto ao sexo e idade, e variou entre as aldeias. As espécies prevalentes foram: Entamoeba histolytica/Entamoeba dispar (48,9%, Giardia duodenalis (32%, Entamoeba coli (40,8%, Endolimax nana (10,3%, ancilostomídeos (37,9%, Schistosoma mansoni (23,7%, Hymenolepis nana (18,6%, Strongyloides stercoralis (5,4%, Ascaris lumbricoides (4,9% e Trichuris trichiura (0,5%. Os Maxakali vivem em condições de vulnerabilidade social, e medidas de infraestrutura e de educação em saúde necessitam ser implementadas pelas instituições governamentais.El objetivo de este estudio fue determinar la prevalencia de parásitos intestinales en la etnia Maxakali. Los exámenes parasitológicos de las heces se realizaron a través de la técnica TF-Test, las muestras fecales se recogieron en tres días alternados, en tubos independientes, conteniendo formol a un 10%, unificados para un doble filtrado por centrifugación. Triplicados de una alícuota del sedimento se examinaron en microscopio (10x y 40x para la identificación de huevos, quistes y larvas. La prevalencia de parásitos (89,5% y del poliparasitismo (46% fue semejante en cuanto al sexo y edad, y varió entre las aldeas. Las especies prevalentes fueron: Entamoeba histolytica/Entamoeba dispar (48,9%, Giardia duodenalis (32%, Entamoeba coli (40,8%, Endolimax nana (10,3%, ancilostomídeos (37,9%, Schistosoma mansoni (23,7%, Hymenolepis nana

  6. De la microflore intestinale aux maladies hépatiques

    OpenAIRE

    Cunningham, Sophie

    2011-01-01

    Les hépatopathies alcoolique et non-alcoolique sont responsables d'une importante morbidité et mortalité. L'absence d'un traitement efficace prouvé pour ces maladies découle d'une compréhension imparfaite de leur pathogenèse. Les mécanismes physiopathologiques menant à ces hépatopathies sont l'objet d'intenses recherches expérimentales et cliniques. Dans ce contexte, un concept ayant évolué depuis plus d'un siècle a abouti, récemment, à une approche révolutionnaire du problème. Ce travail exa...

  7. Enfermedades inflamatorias intestinales: Experiencia de dos centros chilenos

    OpenAIRE

    Figueroa C,Carolina; Quera P,Rodrigo; Valenzuela E,Jorge; JENSEN B,CHRISTIAN

    2005-01-01

    The incidence of Inflammatory Bowel Disease (IBD) has increased, particularly in the developed world, and probably also in Chile. Aim: To report our experience with a large group of patients from two medical centers, Hospital Clinico de la Universidad de Chile (HCUCH) and Clinica Las Condes (CLC) and to characterize the clinical features of IBD in Chile. Patients and methods: Retrospective review of 238 patients with IBD (age range 14-78 years, 143 women) treated at HCUCH and CLC between Janu...

  8. Intestinal helminths of Lutjanus griseus (Perciformes: Lutjanidae from three environments in Yucatán (Mexico, with a checklist of its parasites in the Gulf of Mexico and Caribbean region Helmintos intestinales de Lutjanus griseus (Peciformes: Lutjanidae recolectados en tres ambientes de Yucatán (México, con una lista de sus parásitos en las regiones del golfo de México y el Caribe

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    Nelly Argáez-García

    2010-12-01

    Full Text Available A survey of intestinal helminth parasites of the gray snapper, Lutjanus griseus, collected at the estuarine coastal lagoon of Celestún and off the coast of the localities of Chelem and Progreso (Yucatán, Mexico is presented together with a checklist of gray snapper intestinal helminths in the Gulf of Mexico and the Caribben region. Twenty helminth species were found at the Yucatán localities. Eigth of these have previously been reported in the Gulf of Mexico and the Caribbean region and 12 are new records for L. griseus, which increases the number of species recorded for gray snapper in the region to 44. Only 8 helminth species were recorded from fishes collected inside the coastal lagoon, while all 20 were found in fishes from offshore. Differences in species composition and infection parameters of each helminth species between both habitats are presented and discussed, together with similarities in species composition of the intestinal helminth fauna of L. griseus from Yucatán with those reported for the same host species in the Atlantic coast of USA, the Gulf of Mexico and the Caribbean regions.En este trabajo se presentan los resultados del análisis helmintológico de los tractos digestivos de pargos Lutjanus griseus colectados en la laguna costera de Celestún y en la zona marina frente a las localidades de Chelem y Progreso (Yucatán, México junto con una lista de los helmintos intestinales registrados para esta especie de hospedero en el golfo de México y la región del Caribe. Veinte especies de helmintos fueron recuperadas en las localidades de Yucatán. Solamente 8 de éstas se han registrado previamente en el golfo de México y el mar Caribe. Doce especies de helmintos son nuevos registros para L. griseus, incrementando así a 44 el número de especies para este hospedero en la región. Solo 8 especies de helmintos se recuperaron de los peces colectados en la laguna costera, mientras que todas las 20 especies se encontraron en

  9. A clinical study on the therapeutic effect of rituximab in combination with autologous peripheral blood stem cell transplantation in treatment of CD20+ B cellulous non-Hodgkin lymphoma

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    Yong-sheng CHEN

    2013-07-01

    Full Text Available Objective To investigate the therapeutic effect of autologous peripheral blood stem cell transplantation (APBSCT in combination with rituximab in treatment of CD20+ B cellulous non-Hodgkin's lymphoma (B-NHL. Methods Sixty patients with CD20+ aggressive or refractory and recurrent B-NHL and treated with APBSCT in our department from Jan. 2005 to Jan. 2011 were admitted. All the subjects were divided into 2 groups according to their own choice: 25 patients received rituximab treatment (treatment group and 35 patients were treated without rituximab treatment (control group. All patients underwent chemotherapy and APBSCT. For patients in treatment group, rituximab was used with CHOP before collecting the stem cells and after the transplantation. After transplantation, rituximab and IL-2 were used in treatment group every 3-6 months as maintenance treatment. Results No side effect was observed during the use of rituximab either before or after transplantation. The mononuclear cell count in treatment and control group was (8.2±2.9×108/kg and (8.4±3.9×108/kg (P=0.822, respectively; CD34+cell count was (12.3±12.7×106/kg and (13.2±13.9×106/kg (P=0.799, respectively. Haemopoiesis reconstruction was successfully achieved in the patients of treatment group, while 3 patients in control group failed to have haemopoiesis reconstruction. No significant difference was found between two groups on the recovery time of neutrophilic granulocytes and platelets. All patients achieved complete remission. The average follow-up time was 22 months. The disease relapsed in two patients in treatment group and six in control group. The 3-year overall survival rate in treatment group (91.6% was a little higher than that in control group (69.5%, P=0.060. Conclusion To patients of CD20+ B lymphoma, the use of rituximab shows no side effect before or after collection of stem cell and hemopoiesis reconstruction, and the overall survival rate may be improved.

  10. Fatores associados à ocorrência de parasitoses intestinais em uma população de crianças e adolescentes Factores asociados a la ocurrencia de parasitosis intestinales en una población de niños y adolescentes Factors associated with intestinal parasitosis in a population of children and adolescents

    Directory of Open Access Journals (Sweden)

    Vinícius Silva Belo

    2012-06-01

    Full Text Available OBJETIVOS: Analisar a prevalência de infecções por parasitos intestinais em crianças e adolescentes matriculados em escolas de ensino fundamental no município de São João del-Rei, Minas Gerais, e os fatores associados à infecção. MÉTODOS: Estudo epidemiológico seccional, realizado entre março/2008 e julho/2009. Foram realizados exames coproscópicos por sedimentação espontânea e Kato-Katz em 1.172 escolares. Foram ajustados modelos de regressão logística múltipla para o estudo dos fatores associados às infecções em geral e, separadamente, por helmintos e por protozoários. RESULTADOS: A prevalência de infecções foi de 29%, havendo uma variação de 7 a 83%, respectivamente, entre as escolas de menor e maior ocorrência. A presença de instalação sanitária no domicílio foi associada a uma ocorrência menor de helmintos; o aumento na idade dos escolares associou-se a uma maior ocorrência de protozoários e de parasitos em geral; enquanto a presença de filtro de água e a localização do domicílio em área urbana mostraram-se associadas a uma ocorrência menor dos três desfechos analisados. Em todas as regiões, foi registrado o consumo de medicação preventiva contra helmintos. CONCLUSÕES: Desigualdades nas condições de vida tornaram as prevalências diferenciadas entre as regiões do estudo. O estudo ressalta a necessidade de promover o uso de filtros de água nas residências de áreas endêmicas e de avaliar o consumo preventivo de medicamentos anti-helmínticos na dinâmica e na saúde dos indivíduos. Medidas de controle que levem em conta os fatores descritos devem ser prioritárias em nível de Saúde Pública.OBJETIVOS: Analizar la prevalencia de infecciones por parasitas intestinales en niños y adolescentes matriculados en escuelas de enseñanza primaria en el municipio de São João del-Rei, Minas Gerais (Brasil, y los factores asociados a la infección. MÉTODOS: Estudio epidemiológico seccional

  11. Oral glutamine in addition to parenteral nutrition improves mortality and the healing of high-output intestinal fistulas Glutamina oral en adición a nutrición parenteral mejora la mortalidad y la cicatrización de fístulas intestinales de alto débito

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    J. E. de Aguilar-Nascimento

    2007-12-01

    Full Text Available Objective: Anastomotic leakage is one of the most important causes of morbidity and mortality in gastrointestinal surgery. We investigated the effect of oral glutamine on the healing of high-output intestinal fistula. Setting: A tertiary Universitary Hospital of the University of Mato Grosso, Cuiaba, Brazil. Patients and methods: 28 patients (25 males and 3 females; median age = 45 [18-71] years old admitted with high output post-operative small bowel fistulas (median volume in 24 h: 850 [600-2,200] mL during a 4 years period were retrospectively studied. Interventions: In the first two years 19 (67.9% patients received only TPN as the initial nutritional support. In the last two years however, due to a change in the protocol for the nutritional support in cases of intestinal fistula 9 patients (32.1% received oral glutamine (0.3 g/kg/day; 150 mL/day in addition to TPN. Endpoints of the study were mortality, resolution of the fistula, and length of hospital stay (LOS. Results: The overall mortality was 46.4% (13 patients. Fistula closure was observed in all other 15 patients (53.6% that survived. In the subset of survived patients LOS was similar in those who received or not received glutamine. The multivariate regression analysis showed that resolution of the fistula was 13 times greater in patients that received oral glutamine (OR = 13.2 (95% CI = 1.1-160.5; p = 0.04 and 15 times greater in non-malnourished patients (OR = 15.4 [95% CI = 1.1- 215.5]; p = 0.04. Conclusions: We conclude that oral glutamine accelerated the healing and diminished the mortality in this series of patients with post-operative high-output intestinal fistula receiving TPN.Objetivo: La fístula anastomótica es una de las principales causas de morbilidad y mortalidad en cirugía general. Investigamos el efecto de la glutamina oral en la cicatrización de fístulas intestinales de alto débito. Ámbito: Una unidad terciaria de un Hospital Universitario de la Universidad

  12. CELLULES SOLAIRES PHOTOVOLTAÏQUES PLASTIQUES NANOSTRUCTUREES

    OpenAIRE

    Derbal-Habak, Hassina

    2009-01-01

    The photovoltaic effect is one of the options which significantly developed during the last years in order to find an alternative to non-renewable energy production. In order to reduce the manufacturing costs of photovoltaic devices, a solution consists in replacing silicon by organic materials. The organic solar cells are an emerging technology which ambitions the supply of more flexible solar cells in all the meanings of the term: mechanics, manufacture, electrooptic properties. A challenge...

  13. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature.

  14. Parasitoses intestinais se associam a menores índices de peso e estatura em escolares de baixo estrato socioeconômico Parasitosis intestinales se asocian con menores índices de peso y estatura en niños de bajo nivel económico Intestinal parasitoses are associated with lower values of weight and height in school-aged children from low socioeconomic level

    Directory of Open Access Journals (Sweden)

    Humberto B. Araujo Filho

    2011-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência de parasitoses intestinais, correlacionando-as com os fatores socioeconômicos e ambientais, peso, estatura e hemoglobina, em crianças de dois estratos socioeconômicos, no município de Osasco (SP. MÉTODOS: Estudo transversal, comparando 84 crianças de seis a dez anos, residentes em área sem saneamento básico e moradia precária, com 35 crianças de escola particular no mesmo município, que possuíam boas condições socioeconômicas e de moradia. Excluíram-se aquelas com diarreia há menos de 30 dias ou doença grave. Utilizou-se questionário padronizado para avaliar as condições socioambientais. A avaliação nutricional foi realizada mediante escores Z de peso para idade, estatura para idade e índice de massa corpórea. A determinação da hemoglobina em amostra de sangue capilar foi realizada pelo método Hemocue® e a pesquisa de parasitas intestinais, pelos métodos de Hoffman, Ritchie, Kinyoun e swab anal. RESULTADOS: Parasitose intestinal ocorreu em 60,7% das crianças da favela e em 5,9% das crianças da escola particular (pOBJETIVO: Evaluar la prevalencia de parasitosis intestinales correlacionándolas con los factores socioeconómicos y ambientales, peso, estatura y hemoglobina, en niños de dos niveles socioeconómicos en el municipio de Osasco, São Paulo (Brasil. MÉTODOS: Se realizó un estudio transversal, comparando 84 niños entre 6 y 10 años, residentes en área sin saneamiento ambiental y vivienda precaria, con 35 niños de escuela privada en el mismo municipio, que poseían buenas condiciones socioeconómicas y de vivienda. Se excluyeron aquellas con diarrea hace menos de 30 días o enfermedad grave. Se utilizó cuestionario estandarizado para evaluar las condiciones socioambientales. La evaluación nutricional fue realizada mediante escores Z de peso para la edad, estatura para la edad e índice de masa corporal. La determinación de la hemoglobina en muestra de sangre capilar

  15. Evaluation of node involvement in non small cell bronchogenic carcinoma. CT-pathology correlation; Valutazione del fattore <> nel carcinoma polmonare non a piccole cellule. Correlazione tra tomografia computerizzata e anatomia patologica

    Energy Technology Data Exchange (ETDEWEB)

    Pirronti, T.; Macis, G.; Sallustio, G.; Minordi, L.M.; Marano, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Radiologia; Granone, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Patologia Chirurgica; Vecchio, F.M. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Anatomia Patologica

    2000-05-01

    metastasis and 2 had lymph nodes either over or less than 1 cm. In all N2 patients the tumor histotype and the mediastinal location were also considered relative to the lesion site. A closer correlation was found with node morphology and density than with size. Indeed, CT sensitivity, specificity and diagnostic accuracy were 97, 100 and 97%, respectively, for the former versus 52, 93 and 77% for the latter. Adeno-carcinoma was the predominant histotype (70.5%) in N2 patients. Metastases to node region 4 were predominant in right upper lobe carcinomas while node region 5 was predominant in left upper lobe lesions. Other criteria can be associated with size to improve CT diagnostic accuracy in N staging. Technique optimization plays a major role particularly in the late, thin slice, examination phase. [Italian] Scopo di questo lavoro e' valutare il ruolo della TC nell'identificazione di altri segni morfologici di interessamento metafisico dei linfonodi con la finalita' di ottenere migliore definizione del fattore N poiche' elemento critico nella stadiazione di un carcinoma polmonare non a piccole cellule e' il fattore N: essendo il diametro l'unico parametro usato per distinguere i linfonodi normali da quelli patologici, la TC del mediastino presenta accuratezza diagnostica solamente dell'80%. Sono stati studiati 137 pazienti con carcinoma polmonare noto o sospetto. Le scansioni TC sono state eseguite con la seguente tecnica: fase angiografica precoce con tecnica spirale e fase tardiva (ritardo 2 minuti, spessore 3 mm, intervallo 5 mm) per l'identificazione delle caratteristiche linfonodali. Nelle scansioni TC cosi' ottenute i linfonodi, localizzati in accordo alla mappa linfonodale secondo l'American Thoracic Society modificata da Mountain e Dresler, sono stati considerati nomrali quando non visibili o, se visibili, con diametro inferiore a un cm e con densita' omogenea; un linfonodo con diametro superiore a un cm con

  16. 深圳市大鹏新区儿童小细胞低色素性贫血流行现状及病因探讨%Epidemic Situation and Causes of Children of Cellule Low Pigment Anemia in Shenzhen Dapeng New District

    Institute of Scientific and Technical Information of China (English)

    招湛静; 徐威力; 姚雪淦

    2016-01-01

    目的:了解深圳大鹏新区儿童小细胞低色素性贫血患病现状,为儿童小细胞低色素性贫血的预防和治疗提供科学依据。方法随机收集2014年9月~2016年1月来医院体检儿童2256例,分别对儿童个体中的血液学指标和珠蛋白基因型及铁代谢状态进行检测。结果2256例体检儿童小细胞低色素性贫血患病率为10.6%(239/2256);经基因分析,239例小细胞低色素性贫血患儿中分别检出α-珠蛋白生成障碍性贫血113例[并发铁缺乏症(ID)35例],β-珠蛋白生成障碍性贫血70例(并发ID 15例),α-复合β-珠蛋白生成障碍性贫血28例(并发ID 4例),铁缺乏139例(并发珠蛋白生成障碍性贫血54例),珠蛋白生成障碍性贫血检出率为64.9%(155/239),铁缺乏检出率为58.2%(139/239),珠蛋白生成障碍性贫血并发 ID的发生率为34.8%(54/155);单纯性小细胞低色素症(MCV 和 MCH 均降低,但不贫血)患儿32例,占13.4%(32/239);珠蛋白生成障碍性贫血基因总检出率为65.6%和总携带率为75.0%,其中α-珠蛋白生成障碍性贫血基因缺陷类型主要为--SEA/αα,-α3.7/αα及-α4.2/αα,占93.8%;β-珠蛋白生成障碍性贫血基因缺陷类型主要为 CD41/42,CD17,IVS-II-654及-28,占84.2%。结论深圳大鹏新区儿童发生小细胞低色素性贫血最主要原因是珠蛋白生成障碍性贫血,尤其在单纯性小细胞低色素症中更为突出,其次为 ID和珠蛋白生成障碍性贫血并发 ID。同时,还发现 ID个体有较高的珠蛋白生成障碍性贫血基因检出率,应引起临床和社会高度重视。%Objective To understand the shenzhen Dapeng new district children of cellule low pigment anemia disease status of cellule low pigment anemia for children provide a scientific basis for prevention and treatment.Methods Randomly col-lected 2 256 cases

  17. Integrative treatment of Chinese and Western medicine in the treatment of 24 patients with diabetes combined with acute cellulitis%中西医结合治疗糖尿病并发急性蜂窝组织炎24例

    Institute of Scientific and Technical Information of China (English)

    李轶群; 李亦聪; 钟启腾

    2012-01-01

    目的 观察加味四妙勇安汤治疗糖尿病并发急性蜂窝组织炎的疗效.方法 将在我科住院的48例糖尿病并发急性蜂窝组织炎患者随机分为对照组和观察组,每组各24例.两组均给予基础病、常规换药及抗生素治疗.观察组在对照组治疗基础上给予加味四妙勇安汤治疗.结果 两组总有效率比较差异有统计学意义(P < 0.05);观察组治愈时间及有效时间分别为(12.33±0.94)d及(8.57±1.50)d,均少于对照组,两组比较差异有统计学意义(P < 0.05).结论 使用加味四妙勇安汤治疗糖尿病并发急性蜂窝组织炎,能加快减轻患部肿痛,缩短感染治疗时间,疗效显著.%Objective To observed the efficacy of the Decoction of Four Well-matched Potent Herbs for Stopping Groaning in the treatment of diabetes combined with acute cellulitis. Methods 48 patients hospitalized in our department were selected and randomly divided into control group and observation group with 24 patients for each group. Two groups were given foundational disease, conventional medication and antibiotics treatment. The observation group was given the Decoc -tion of Four Well-matched Potent Herbs for Stopping Groaning based on the treatment of the control group. Results Comparison of the two groups showed statistical significance (P < 0.05); but the healing time and improvement time of the observation group were (12.33±0.94) d and (8.57±1.50) d respectively, both of which were less than those of the control group (P < 0.05). Conclusion The application of Decoction of Four Well-matched Potent Herbs for Stopping Groaning in the treatment of diabetes combined with acute cellulitis can accelerate pain and swelling relieving in the affected area and re -duce infection treatment time. Therefore it is significantly effective.

  18. Citotossicity in immune system's cells exposed in vitro to a microwave electromagnetic field in two different exposure systems operating at mobile telephones frequencies; Citotossicita' in cellule del sistema immunitario esposte in vitro al campo elettromagnetico a microonde in due diversi sistemi espositivi operanti alle frequenze della telefonia mobile

    Energy Technology Data Exchange (ETDEWEB)

    Scarcella, E.; Ardoino, L.; Galloni, P.; Mancini, S.; Marino, C. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    funzionamento di cellule macrofagiche stabilizzate e coltivate in vitro (RAW 264.7) responsabili dei meccanismi di difesa specifica e aspecifica del sistema immunitario. Sono stati, inoltre, standardizzati due diversi sistemi espositivi operanti a 900 MHz a differenti livelli di densita' di potenza (da 1 a 100 W/m{sup 2}) per garantire condizioni elettromagnetiche omogenee, idonee condizioni di incubazione delle cellule e la riproducibilita' degli esperimenti. Il lavoro di standardizzazione dei sistemi espositivi e i risultati sperimentali di questa ricerca, che hanno evidenziato differenze significative della crescita e della funzionalita' macrofagica solo al livello di densita' di potenza piu' elevato (100 W/m{sup 2}), ma recuperare dopo 48 ore dall'esposizione, risultano essere preliminari e propedeutici per una programmazione sperimentale futura atta ad approfondire una valutazione bio-tossicologica in vitro.

  19. Acute hypocomplementemic post-infectious glomerulonephritis as a complication of sinus-related orbital cellulitis: case report Glomerulonefrite pós-infecciosa hipocomplementêmica aguda como complicação de celulite orbitária relacionada aos seios paranasais: relato de caso

    Directory of Open Access Journals (Sweden)

    Jayter Silva Paula

    2008-08-01

    Full Text Available Group A beta-hemolytic streptococcus is the most common agent implicated in post-infectious acute glomerulonephritis. We report a case of acute poststreptococcal glomerulonephritis associated with sinus-related orbital abscess in an 11-year-old boy treated with surgical drainage and intravenous ceftriaxone and clindamycin. Twelve days after supportive measures, renal function was normalized. We also discuss this potentially severe nonsuppurative complication of orbital cellulitis caused by group A beta-hemolytic streptococcus.Os estreptococos beta-hemolíticos do grupo A são os agentes mais comumente envolvidos na glomerulonefrite aguda pós-infecciosa. Relatamos um caso de glomerulonefrite pós-estreptocócica aguda associada a um abscesso orbitário secundário à sinusite, em menino de 11 anos de idade, o qual foi tratado com ceftriaxona e clindamicina endovenosas e drenagem cirúrgica. Doze dias após tratamento de suporte, a função renal se normalizou. Também discutimos a importância desta grave e potencial complicação não supurativa das celulites orbitárias causadas pelos estreptococos beta-hemolíticos do grupo A.

  20. INDUCTION DE L'IFN- SUR CULTURE DE CELLULES PÉRIPHÉRIQUES MONONUCLÉES CIRCULANTES DE PATIENTS ATTEINTS D'HYDATIDOSE SOUS L'INFLUENCE DE L'ANTIGÈNE-5. PURIFICATION DE L'ANTIGÈNE-5.

    Directory of Open Access Journals (Sweden)

    C TOUIL-BOUKOFFA

    2000-12-01

    Full Text Available L'interféron gamma est produit sur des cultures de cellules mononuclées circulantes stimulées par un antigène parasitaire isolé d'un liquide hydatique hépatique (Antigène-5. L'Antigène-5 est purifié sur SEPHADEX G-200 et identifié comme l'antigène majeur. Notre étude décrit les conditions optimales de production. Le niveau maximal d'interféron est atteint pour une concentration antigénique allant de 2 à 20mg/ml d'Antigène-5. Les titres obtenus sont de 64 U/ml. Le surnageant est absorbé sur acide silique, l'activité antivirale est éluée par un tampon de haute force ionique contenant de l'éthylène glycol et soumis à une chromatographie d’affinité: BLEU SEPHAROSE- CL-6B.  Ce traitement permet une production d’interféron répondant à une activité spécifique de 561,79 U/mg. Nos résultats montrent l’éventuelle implication de cette cytokine dans la défense immunitaire au cours de cette parasitose.

  1. Infarkte an mesenterischen Lymphknoten und intestinale Gangrän durch Ascaris lumbricoides bei einem Kind

    OpenAIRE

    Bhutia, Kincho Lhasong; Dey, Subhajeet; Singh, Varun; Gupta, Amlan

    2011-01-01

    Ascaris lumbricoides or round worm infestation is quite common in the developing world. It affects all age groups but is more common in children. Most of the cases remain asymptomatic. The usual presentation is an intestinal obstruction. The physicians should be aware of this condition and consider it in the differential diagnosis when faced with such a case. The rare fatal complications include bleeding, perforation and gangrene. In Entwicklungsländern ist der Befall mit Ascaris lumbricoi...

  2. L’aluminium, facteur de risque environnemental impliqué dans la physiopathologie des maladies intestinales

    OpenAIRE

    2016-01-01

    Aluminium (Al) is the most abundant metal in our environment. Al naturally occurs in soils, rocks, minerals, air, water and its use in consumer products increase exponentially in industrialized countries. During last decades, human activities led to an increase in the bioavailability of Al and populations are exposed daily to multiple sources and doses of Al, including the oral route. Based on the description of toxic and deleterious effects of Al in various pathologies as well as ingested do...

  3. Encuesta de helmintos intestinales en la provincia de Sandia (Departamento de Puno)

    OpenAIRE

    2013-01-01

    En 290 sujetos de la provincia de Sandia, departamento de Puno, el examen microscópico de una muestra de heces proveniente de cada uno de ellos, mostró: 1. La incidencia del parasitismo intestinal a helmintos es considerablemente alta (91. 03% ) 2. La incidencia por especie de parásito que se ha determinado es la siguiente: 3. La incidencia por localidades, en el caso de Ancylostoma o Necator y de S. stercoralis, aumenta a medida que se desciende hacia la Selva. 4. La asociación de helmintos...

  4. Encuesta de helmintos intestinales en la provincia de Sandia (Departamento de Puno

    Directory of Open Access Journals (Sweden)

    Efraín Santillana

    1956-12-01

    Full Text Available En 290 sujetos de la provincia de Sandia, departamento de Puno, el examen microscópico de una muestra de heces proveniente de cada uno de ellos, mostró: 1. La incidencia del parasitismo intestinal a helmintos es considerablemente alta (91. 03% 2. La incidencia por especie de parásito que se ha determinado es la siguiente: 3. La incidencia por localidades, en el caso de Ancylostoma o Necator y de S. stercoralis, aumenta a medida que se desciende hacia la Selva. 4. La asociación de helmintos más frecuente ha sido Ascaris lumbricoides-Trichocephalus trichiurus.

  5. Metástasis intestinales yeyunales, forma de presentación de un carcinoma pulmonar

    Directory of Open Access Journals (Sweden)

    D. Ruiz-Clavijo García

    2015-04-01

    Full Text Available Los tumores primarios de intestino delgado son muy infrecuentes, siendo todavía más raros los metastásicos. Es excepcional que las metástasis de intestino delgado se manifiesten antes que el tumor primario. La presentación clínica puede requerir una resección quirúrgica intestinal motivada por perforación, hemorragia, obstrucción-suboclusión intestinal e incluso invaginación intestinal. La supervivencia, es escasa y generalmente no supera las 20 semanas, independientemente del tratamiento que se realice.

  6. Intestinal small bowel lymphomas - diagnosis and treatment; Primaer intestinale Lymphome - Diagnosestellung mittels CT und Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Goessmann, H.; Reith, H.B. [Klinikum fuer Visceral-, Thorax und Gefaesschirurgie, Klinikum Konstanz (Germany); Goerlitz, T.; Beck, A. [Inst. fuer Roentgendiagnostik und Nuklearmedizin, Klinikum Konstanz (Germany)

    2006-07-01

    Primary intestinal lymphomas are most common in the stomach. The mucosa associated lymphatic tissue (MALT)-lymphoma which is closely associated with helicobacter pylori is very well known. In most cases, these malignancies are from B-cells origin. Another possible point of manifestation, although not well known, is the small bowel. Both tumors have enormous capabilities to enlarge in the abdominal cave. This is responding to their often asymptomatic manifestation. The symptoms, if they occur, are widespread and unspecific. Ileus, diarrhae, abdominal pain or bleeding will be observed, in rare cases also perforation or gastrointestinal or cutaneous fistulas. Diagnostic imaging often demonstrates a tumour of massive size by then, which is echopoor in the abdominal ultrasound. Our report concerns two cases of small intestine lymphomas, which were diagnosed by CT-scanning and treated in our clinic in only a short period of time. The first case was a low malignant jejunal lymphoma which was almost asymptomatic, whereas the second case had an ileus, due to compression of the intestine because of a high malignant lymphoma of the ileocecal region. (orig.)

  7. Remote cells destruction; Detruire les cellules a distances

    Energy Technology Data Exchange (ETDEWEB)

    Pezet, A

    2009-11-15

    Three methods for a non invasive surgery are described. High intensity focused ultrasonics to treat an uterine fibroma or prostate cancer presents the advantages to destroy ill cells by high temperature (80 to 100 celsius degrees and the millimetric precision allows to preserve the sane tissues. Echography is used to give images and the volume to treat then are sent the high intensity focused ultrasonics (H.I.F.U.) to destroy the tumor. A second method progresses, the laser method: a thin beam of light, coming from a laser diode and transmitted by an optical fiber of 200 microns diameter comes and heats and kills the cancerous cells. With NMR imaging the cancerous cells from 1 to 2 mm are detected but its is necessary to introduce the optical fiber in the ill tissue. The third method concerns protons therapy used in radiotherapy. The beam energy determines the depth where the protons stop and give their energy (with a 201 MeV energy range the tumors located at 32 centimeters under the skin can be destroyed.The volume to treat is determined with a scanner and a three dimensional calculation reconstruction of image. (N.C.)

  8. Not What It Seems: Deep Tissue Infection Presenting as Cellulitis

    Directory of Open Access Journals (Sweden)

    Caroline T. Brandon

    2015-10-01

    Full Text Available A 34-year-old male with diabetes presented to the emergency department with four days of progressively worsening redness, swelling and pain to his left buttock. The patient denied fevers, chills, rectal pain or purulent drainage from his rectum. His initial vital signs were heart rate of 82; blood pressure of 146/92; and temperature of 98.2°F. The left buttock had a poorly circumscribed area of induration; however, there was no fluctuance or crepitace. Rectal exam was unremarkable. Because the patient’s buttock pain was disproportionate to his exam findings, a point-of-care ultrasound was performed to determine if a more extensive process was present. The ultrasound demonstrated cobblestoning, fascial thickening with edema, and a large 4.5cm fluid collection extending and adjacent to the rectum.

  9. Presencia de parásitos intestinales en muestras de heces de empleados administrativos de una universidad privada.

    OpenAIRE

    Avelar, Verónica María; Santos Herrera, René Guillermo

    2014-01-01

    El presente trabajo consistió, en la recolección y análisis parasitológico de las muestras de heces provenientes de los empleados del área administrativa de una universidad privada durante el mes de septiembre del 2013. Las muestras fueron identificadas por edad,fecha,lugar de residencia y área de trabajo al que pertenece cada uno de los empleados.Todos los participantes dieron su aval de ser incluidos en el estudio a través de la firma de consentimiento informado.La metodología utilizada par...

  10. Efectos de un producto soluble de cacao rico en polifenoles sobre los hábitos intestinales de voluntarios sanos

    OpenAIRE

    Sarriá, Beatriz; Martínez López, Sara; Goya, Luis; Bravo, Laura

    2010-01-01

    Trabajo presentado al II Congreso de la Federación Española de Sociedades de Nutrición, Alimentación y Dietética FESNAD: "Hacia una alimentación responsable" celebrado del 3 al 5 de Marzo de 2010 en Barcelona (España).

  11. Tratamiento psicológico protocolizado en grupo de las enfermedades inflamatorias intestinales: efectos sobre la calidad de vida

    OpenAIRE

    Miguel Ángel Díaz-Sibaja; María Isabel Comeche-Moreno; Blanca Mas-Hesse; Marta Díaz García; Miguel Ángel Vallejo Pareja

    2008-01-01

    La enfermedad inflamatoria intestinal (EII) es una enfermedad crónica que afecta notablemente a la calidad de vida del paciente. El principal objetivo de este estudio fue demostrar la eficacia de un programa de tratamiento psicológico protocolizado para mejorar la calidad de vida de estos pacientes. La muestra estuvo constituida por 57 pacientes diagnosticados de EII (33 programa de tratamiento en grupo y 24 grupo control en lista de espera). Las variables dependientes fueron: síntomas digest...

  12. Evaluatie van de mini-FLOTAC-methode voor de detectie van gastro-intestinale parasieten bij grote huisdieren

    OpenAIRE

    2016-01-01

    A new technique, mini-FLOTAC, has recently been developed for the microscopic diagnosis of infections with gastro-intestinal nematodes in domestic animals. In this comparative study of diagnostic techniques, the mini-FLOTAC technique was compared to the commonly used McMaster technique for the detection and quantification of gastro-intestinal parasites in livestock as well as for the evaluation of the time needed to perform the assays. One hundred fecal samples (78 horses, 11 bovines, 6 sheep...

  13. Tratamiento psicológico protocolizado en grupo de las enfermedades inflamatorias intestinales: efectos sobre la calidad de vida

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Díaz-Sibaja

    2008-01-01

    Full Text Available La enfermedad inflamatoria intestinal (EII es una enfermedad crónica que afecta notablemente a la calidad de vida del paciente. El principal objetivo de este estudio fue demostrar la eficacia de un programa de tratamiento psicológico protocolizado para mejorar la calidad de vida de estos pacientes. La muestra estuvo constituida por 57 pacientes diagnosticados de EII (33 programa de tratamiento en grupo y 24 grupo control en lista de espera. Las variables dependientes fueron: síntomas digestivos, síntomas sistémicos, afectación funcional, función emocional y afectación social (Cuestionario de calidad de vida en la enfermedad inflamatoria intestinal (SIBDQ, López-Vivancos y cols., 1999. Los resultados revelan que el programa de tratamiento psicológico resultó eficaz para producir una mejoría significativa en todas las variables de calidad de vida a la finalización del mismo, al compararlo con el grupo control en lista de espera. Si bien las diferencias se mantienen en 4 de los 5 aspectos evaluados a los 3 meses de seguimiento, a los 12 sólo se mantienen las diferencias en uno de ellos.

  14. A pilot plant for solar-cell manufacture; Ligne pilote de fabrication de cellules solaires

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D.; Ziegler, Y.; Closset, A. [VHF - Technologies SA, Yverdon-les-Bains (Switzerland)

    2005-07-01

    A pilot plant for the manufacture of amorphous silicon solar cells on plastic film substrate was built allowing the annual production of 40 kW peak power. The production steps comprise: a) the continuous coating of n-i-p solar cells by VHF-PECVD with a capacity of 28.5 meters in 8.5 hours; b) transparent-conducting-oxide (TCO) top contact structuring using a continuous process; c) series connection step (scribing and Ag-paste) with a capacity of 28 meters in 6 hours; d) back and top contact sputtering with 3 parallel magnetrons; e) integration of a large-area vacuum laminator enabling the simultaneous lamination of 4 products of 4 Wp. In parallel with this project, a complete cost model was established enabling a more quantitative approach of the future technological and industrial strategy of the company. An increase of the capacity to 100 kWp has been planned for summer 2005.

  15. La cellule d'essais du LHC fonctionne avec succès pendant 24h

    CERN Multimedia

    CERN Press Office. Geneva

    1994-01-01

    On 6 and 7 December a string of powerful superconducting magnets for CERN's next particle accelerator the Large Hadron Collider (LHC) ran successfully at 8.36 Tesla for 24 hours. 8.36 Tesla is the magnetic field required to accelerate protons to the required energy for LHC and this result demonstrates that the key technical choices made for the construction of the LHC magnets were correct. The test magnets have shown that they can operate reliably under the same working conditions as the future accelerator.

  16. Polymer photovoltaic cells; Etude et realisation de cellules photovoltaiques en polymere

    Energy Technology Data Exchange (ETDEWEB)

    Sicot, L.

    1999-09-29

    We study organic photovoltaic cells based on a semiconducting polymer. The first photovoltaic cells we realize are Schottky cells. Their structure are ITO/Polymeric film/Au. Metallic electrode is made of aluminium or gold. The organic layer is made of pure poly(3-butyl-thiophene) or of a blend of the polymer and a dye, the 1,3-bis(di-cyano-methylidene)-2-(4-dibutyl-amino-benzylidene)indane. We study the influence of the nature of the electrode on the conversion efficiency. We also study the variations of the photovoltaic parameters as functions of the thickness of the polymeric film and of the doping ratio of the dye. The performances of this kind of cells depends on the interface between the organic layer and the ITO. Its morphology, particularly its rugosity, and its electrical properties are not easy to control. By depositing a layer of a derivative of perylene on the ITO, we move the photo-generation zone to the interface between the two organic films. The efficiency of this p-n cell is higher than the one measured with the Schottky cell. Nevertheless, we have observed a decrease of the performances of our cells due to the degradation of the dye and the polymer when they are illuminated at high intensity of light during a long time. (author)

  17. Orbital wall infarction mimicking periorbital cellulitis in a patient with sickle cell disease

    Energy Technology Data Exchange (ETDEWEB)

    Ozkavukcu, Esra; Fitoz, Suat; Erden, Ilhan [Ankara University School of Medicine, Department of Radiology, Ankara (Turkey); Yagmurlu, Banu [Kirikkale University School of Medicine, Department of Radiology, Kirikkale (Turkey); Ciftci, Ergin [Ankara University School of Medicine, Department of Paediatric Infectious Diseases, Ankara (Turkey); Ertem, Mehmet [Ankara University School of Medicine, Department of Paediatric Haematology, Ankara (Turkey)

    2007-04-15

    Orbital wall infarction and subperiosteal haematomas are unusual manifestations of sickling disorders. Here we report an 11-year-old girl with sickle cell anaemia having multiple skull infarctions including the orbital bony structures associated with subperiosteal haematomas. The diagnosis was made by MRI, which showed bone marrow changes and associated haemorrhagic collections. The patient was successfully managed without surgical intervention. (orig.)

  18. HIB-INFECTION: MENINGITIS, CELLULITIS IN THE CHILD OF 6 MONTHS

    Directory of Open Access Journals (Sweden)

    G. A. Harchenko

    2015-01-01

    Full Text Available A clinical case of Hib-infection is the clinic purulent meningitis and pannikulita young child. Shows the complexity of the differential diagnosis of meningitis in combination with panniculitis with meningococcal disease (meningitis, meningokokktsemiya.

  19. Response of hematopoietic stem cells to ionizing radiation; Reponse des cellules souches hematopoitiques aux radiations ionisantes

    Energy Technology Data Exchange (ETDEWEB)

    Simonnet, A

    2008-12-15

    Hematopoietic stem cells (HSCs) maintain blood and immune system throughout life and restore them after hematological injuries. Exposure of an organism to ionizing radiation (IR) causes rapid and acute myelosuppression and challenges the replenishment capacity of HSCs. Yet, the precise damages that are generated remain largely unexplored. To better understand these effects, phenotypic and functional changes in the stem/progenitor compartments of sublethally irradiated mice were monitored over a ten week period after radiation exposure. We report that shortly after sublethal IR-exposure, HSCs, defined by their repopulating ability, still segregate in the Hoechst dye excluding side population (SP); yet, their Sca-1 (S) and c-Kit (K) expression levels are increased and severely reduced, respectively, with a concurrent increase in the proportion of SP{sup SK} cells positive for established indicators of HSC presence: CD150{sup +} and CD105{sup +}. A great proportion of HSCs quickly but transiently enter the cell cycle to replenish the bone marrow of myelo-ablated mice. Ten weeks after, whereas bone marrow cellularity has recovered and hematopoietic homeostasis is restored, major phenotypic modifications can be observed within the Lin{sup -/low} Sca-1{sup +} c-Kit{sup +} (LSK) stem/progenitor compartment: CD150{sup +}/Flk2{sup -} and CD150{sup -}/Flk2{sup +} LSK cell frequencies are increased and dramatically reduced, respectively. CD150{sup +} LSK cells also show impaired reconstitution capacity, accrued number of {gamma}-H2AX foci and increased tendency to apoptosis. This demonstrates that the LSK compartment is not properly restored 10 weeks after sublethal exposure, and that long-term IR-induced injury to the bone marrow proceeds, at least partially, through direct damage to the stem cell pool. Thrombopoietin (TPO) has been shown to promote the survival of lethally irradiated mice when administrated quickly after exposure. We investigated the mechanisms underlying this effect, and found in a competitive transplant experiment that a single TPO administration rescued the IR-impaired reconstitution capacity of HSCs early after exposure. In addition, the use of marrow cells from transgenic ubiquitous luciferase-expressing donors combined with bioluminescence imaging technology provided a valuable strategy that allowed visualizing HSC homing of TPO-treated compared to untreated irradiated donors, and enabled the identification of a preferential cellular expansion sites which were inaccessible to investigation in most studies. Finally, we observed that TPO injection right after irradiation considerably attenuates IR-induced long-term injury to the stem/progenitor compartment. Altogether, these data provide novel insights in the cellular response of HSC to IR and the beneficial effects of TPO administration to these cells. (author)

  20. Cellulitis in a Liver Transplant Patient as an Initial Manifestation of Disseminated Cryptococcal Disease

    Directory of Open Access Journals (Sweden)

    Marcos Davi Gomes de Sousa

    2016-10-01

    Full Text Available A 50-year-old male underwent liver transplantation due to cryptogenic cirrhosis and was admitted with severe pain in the left leg as well as phlogosis. Amoxicillin/clavulanic acid was prescribed, assuming bullous erysipelas. Among the tests performed, the latex agglutination test for the Cryptococcus sp. antigen was positive, and in both the blood culture and blister culture Cryptococcus sp. was isolated. Daily fluconazole was started. Even though liposomal amphotericin B has been started on the fifth day of hospitalization, the patient progressed to death.

  1. Glucolipotoxicité dans les cellules bêta pancréatiques

    OpenAIRE

    Cassel, Roméo

    2014-01-01

    Le diabète de type 2 est une pathologie chronique complexe associant une altération de sécrétion de l'insuline par le pancréas et une résistance à l'insuline au niveau des tissus périphériques, notamment au niveau du foie et du muscle squelettique. Son origine est multifactorielle, alliant des anomalies génétiques et environnementales, en particulier nutritionnelles. Un des mécanismes par lesquels les facteurs nutritionnels (comme les glucides et les lipides en excès) contribuent au développe...

  2. Attivazione delle cellule Natural Killer durante infezione acuta da virus dell'epatite C

    OpenAIRE

    Amadei, Barbara

    2011-01-01

    Il virus dell’epatite C (HCV) è l’agente eziologico di epatiti virali che durante la fase acuta sono spesso asintomatiche, e quindi difficili da diagnosticare. Questo virus è in grado di stabilire un’infezione cronica persistente nella maggioranza degli individui esposti e la risposta immunitaria contro HCV gioca un ruolo importante sia nel controllo virale che nella patogenesi della malattia. Molti lavori hanno studiato il ruolo della risposta dell’immunità adattativa durante la fase acuta d...

  3. ETUDE DES REMANIEMENTS LIPIDIQUES DES CELLULES VEGETALES EN CARENCE DE PHOSPHATE

    OpenAIRE

    Jouhet, Juliette

    2005-01-01

    Phosphate is often a limiting factor for plant growth in soil. In plant cell, phosphate deprivation induces a decrease of phospholipid amount, mobilizing phosphate present in theses molecules. This decrease is compensated by an increase of non phosphorous plastidic glycolipid amount such as digalactosyldiacylglycerol (DGDG). We have shown that under phosphate deprivation a part of phospholipids is transformed into phosphatidylcholine (PC), producing a transitory increase of PC in short time o...

  4. Cellulitis in a Liver Transplant Patient as an Initial Manifestation of Disseminated Cryptococcal Disease

    Science.gov (United States)

    Gomes de Sousa, Marcos Davi; Bernardes Filho, Fred; Barros Costa Fernandes, Luís Eduardo; Guedes Leal, Cássia Regina; Rocha Magalhães, Cristiane; Custódio Neto da Silva, Marcos Antonio; Silva Barcaui, Halime

    2016-01-01

    A 50-year-old male underwent liver transplantation due to cryptogenic cirrhosis and was admitted with severe pain in the left leg as well as phlogosis. Amoxicillin/clavulanic acid was prescribed, assuming bullous erysipelas. Among the tests performed, the latex agglutination test for the Cryptococcus sp. antigen was positive, and in both the blood culture and blister culture Cryptococcus sp. was isolated. Daily fluconazole was started. Even though liposomal amphotericin B has been started on the fifth day of hospitalization, the patient progressed to death. PMID:28101016

  5. Battery charger for solar cells; Chargeur de batterie pour cellules solaires

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-09-01

    The main drawback of solar energy concerns its availability and its intensity variations due to the changes in the clouds cover. For a maximum availability, a photovoltaic power supplies must be connected to a battery. Such an association requires a particular circuit for the management of the battery charging and of the energy conversion whatever the lighting conditions. This article describes the scheme of such a circuit. (J.S.)

  6. The radiation effects on the living cell; Les effets des rayonnements sur la cellule vivante

    Energy Technology Data Exchange (ETDEWEB)

    Sage, E.; Dutrillaux, B.; Soussi, Th. [Institut Curie, 75 - Paris (France)]|[Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France); Boiteux, S.; Lopez, B. [CEA-CNRS/Fontenay-aux-Roses, 92 (France); Feunteun, J. [Institut Gustave Roussy, 94 - Villejuif (France)

    1999-06-01

    This publication is a presentation of particular points discussed during the colloquium of the 15-18 june 1999, for which scientific researches are performed at the CEA/CNRS. They deal with the radiobiology, for the radiation effects on living matter; with the DNA, for the knowledge and repair mechanisms on cells submitted to ionizing radiations; with the exposition to UV in correlation with neoplasms; with the P53 gene which is a tumour suppressor. (A.L.B.)

  7. Orbital cellulitis in course of typhoid fever; Zapalenie tkanki oczodolowej w przebiegu duru brzusznego

    Energy Technology Data Exchange (ETDEWEB)

    Nowacka, K.; Szreter, M.; Mikolajewicz, J. [Centrum Zdrwowia Dziecka, Warsaw (Poland)

    1993-12-31

    In 18 months girl with exophthalmus of the left eye and extensive swelling of the soft tissues in both orbits during continued fever was observed. Typhoid fever with a non-typical course and ophthalmic complications were diagnosed on the basis of serological tests. Complete cure after treatment with augmenting was obtained. (author) 10 refs, 2 figs

  8. Integrated Airframe Design Technology (Les Technologies pour la Conception Integree des Cellules)

    Science.gov (United States)

    1993-12-01

    influencing the variables such as frequencies, system outcome. Each participant can displacements, and cyclic strains, are provide information on the...18E/F Optimized Wing Thickness The system was also used by MDC during the proposal phase of the Single Stage Rocket Technology ( SSRT ) program. The

  9. Etude des interactions entre Helicobacter pylori et les cellules épithéliales gastriques

    OpenAIRE

    Mustapha, Pascale

    2011-01-01

    Infection with Helicobacter pylori causes inflammation that can persist asymptomatically or evolve into more severe pathologies such as gastric or peptic ulcers, MALT lymphoma and gastric cancer. The cag pathogenicity island is one of the major virulence factors of this bacterium. Several cytokines and antimicrobial peptides are involved in modulating the inflammatory response of the gastric epithelial mucosa during infection with H. pylori. This work has focused on the study of the interacti...

  10. Influence de revetements bioactifs sur les cellules endotheliales: Vers des protheses vasculaires non thrombotiques

    Science.gov (United States)

    Fadlallah, Hicham

    Developing vascular prostheses of small diameter to replace vessels closed by atherosclerosis remains a challenge because of the risk of thrombosis. Seeding of endothelial cells, which have antithrombogenic properties, is a promising solution, but we must create surfaces which promote their adhesion and retention to resist shear stresses created by the blood flow on the surface. This master's project aimed at investigating the effect of a plasma polymerized coating rich in primary amines (called LP), with or without elements of the extracellular matrix (Fibronectin (FN) or chondroitin sulphate (CS)) on the endothelial cells and hemocompatibility of polyethylene terephthalate (PET). The adhesion, growth and retention of human umbilical vein endothelial cells (HUVECs) on PET and LP, in the presence and absence of FN or CS, have been studied. In addition, platelet adhesion on different surfaces was evaluated by a perfusion test with whole blood, platelets being previously labeled with rhodamine. Finally a double fluorescent labeling (using Cellview Maroon to mark the HUVECs and CD61 antibody for platelets) was developed to study the retention of endothelial cells, under blood flow and verify their non thrombogenic character. The results obtained show that both the LP coating and the adsorbed FN, strongly increase both the cellular adhesion and growth on PET; however they have no additional effect when the two are combined. They also augment cellular retention to surface, but this remains incomplete. Moreover we observed that the plasma coating (LP) greatly increases the thrombogenicity of the surface, with strong platelet adhesion and activation. This thrombogenicity is extremely reduced when endothelial cells cover the surface, but cell loss under the effect of shear produced by the perfusion creates significant areas of platelet adhesion. The grafting of CS on LP also permits good HUVECs adhesion, growth and retention under shear stress on HUVEC, with no difference from the LP alone. In addition, the CS sharply decreases the platelet adhesion, which is found below the value observed for PET. The double cell labeling also showed that cells adhered on LP+CS has an anti-thrombotic phenotype and can resist blood flow. These studies suggest that a coating of CS is a promising strategy for vascular prosthesis given the combination of the good adhesion of endothelial cells and the low thrombogenicity of the underlying surface. Keywords: vascular prostheses, polymers, bioactive coating, thrombogenicity, HUVECs.

  11. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    OpenAIRE

    2012-01-01

    La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB). Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celuliti...

  12. Part of the HIG-99mTc in the inflammatory illness of intestine. Role de la HIG-99mTc dans la maladie inflammatoire intestinale

    Energy Technology Data Exchange (ETDEWEB)

    Lancha, C.; Curto, L.M.M.; Mitjavila, M.; Vila, T. (Hopital Emaon et Cajal, Madrid (Spain)); Prat, E.; Abos, M.D.; Banzo, J.; Delgado, M. (Hopital Universitaire, Zaragaza (Spain))

    1993-04-01

    The diagnosis of intestine inflammatory illness is based on endoscopy, radiological exploration with contrast product and histological study. This kind of exploration can be contra-indicated during acute episode because of serious complications. Several methods with isotopes were applied because of their low aggressiveness. We realized a study in the aim to precise the role of (HIG)-99mTc (non specific human immunoglobulin) in the evaluation of diagnosis of the intestine inflammatory illness.

  13. Prevalencias de las geohelmintiasis intestinales en 100 municipios de Venezuela (1989-1992 Intestinal nematode prevalences in 100 municipalities from Venezuela

    Directory of Open Access Journals (Sweden)

    Gustavo A. Morales C.

    1999-06-01

    Full Text Available El examen coproparasitológico (técnica de Kato-Katz de un total de 113.254 personas, pertenecientes a 100 municipios de Venezuela, permitió establecer las siguientes prevalencias a nivel nacional: Ascaris lumbricoides: 26,9%, Trichuris trichiura: 32,6% y Anquilostomideos: 5,6%. Además se determinaron los valores de la prevalencia para los mencionados geohelmintos en los 100 municipios considerados observándose una gran variabilidad. Para T. trichiura los valores máximos se obtuvieron en los municipios Arévalo González (54,6%, en el Estado Miranda, Urama (76,9% en el Estado Carabobo y Punta de Piedra (78,4% en el Estado Sucre. Para A. lumbricoides, en los municipios Punta de Piedra (63% y Tunapuy (61,9%, en el Estado Sucre y Arévalo González (62,7% en el Estado Miranda. Mientras que para los Anquilostomideos las prevalencias máximas se detectaron en los municipios El Amparo (39,5% y San Camilo (35,9% en el Estado Apure. En cuanto a la edad las prevalencias más altas se determinaron en niños de edad pre-escolar y escolar, para A. lumbricoides y T. trichiura y en adolescentes y adultos para anquilostomideos.A total of 113254 individuals from 100 venezuelan municipalities were studied by mean of Kato-Katz coprological examination and the geohelminth prevalences were established. The national prevalences of T. trichiura, A. lumbricoides and Anquilostomideos were 32.6%, 26.9% and 5.6% respectivelly. For T. trichiura the highest values were obtained for the following municipalities: Arévalo González (54.6% in Miranda state, Urama (76.9% in Carabobo state and Punta de Piedra (78.4% in Sucre state. For A. lumbricoides the highest values were determined in Punta de Piedra (63%, Tunapuy (61.9% in Sucre state and Arévalo González (62,7% in Miranda state. For hookworm the highest values were detected in El Amparo (39.5% and San Camilo (35.9% in the state of Apure. In relation to the age, the highest prevalence of Ascariosis and Trichuriosis were determined in pre-school and school children and for hookworm in adolescents and adults. A high variability between the municipalities belonging to the same state for the three geohelminths was observed.

  14. PARÁSITOS INTESTINALES DE PERROS CALLEJEROS: RIESGO A LA SALUD PÚBLICA EN SAN RAMÓN, COSTA RICA

    OpenAIRE

    González Bermúdez, Gustavo Adolfo; Alfaro Campos, Katherine; Trejos Trejos, Jeaneth

    2015-01-01

    Con el objetivo de determinar la salud endoparasitaria de los perros callejeros y evaluar la contaminación del suelo por parte de éstos, se analizó el suelo y las heces encontradas en el parque Alberto Manuel Brenes entre marzo y abril del 2011. Se comprobó la presencia de cuatro especies de parásitos en las heces y una especie en las muestras del suelo mediante dos técnicas de muestreo: Sheater y Salina – lugol, resultando 83,33% y 16,6% positivas respectivamente. Los parásitos hallados pued...

  15. intestinal nematodes of medical importance in Colombia: a solved problem? Nemátodos intestinales de importancia médica en Colombia: ¿un problema resuelto?

    OpenAIRE

    Nora A. Zuluaga Espinosa; Jorge Humberto Botero Garcés

    2001-01-01

    Intestinal parasites, in general, constitute a great worldwide, public health problem. Of them, nematodes are among the most outstanding in Colombia. Because these parasites can enter into the organism either by ingestion or through the skin, faulty hygienic-sanitary habits facilitate their transmission and conservation. Among nematodosis the more frequent in Colombia are those caused by Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), hookworms (Necator americanus and Ancylo...

  16. Prevalencia y factores asociados a la Fasciola hepática y otras parasitosis intestinales en la comunidad de Tarqui – 2011

    OpenAIRE

    Orlando Narváez, Alberto

    2011-01-01

    Se realizó un estudio de corte transversal en 236 pobladores residentes de la parroquia Tarqui centro y 478 bovinos de 13 haciendas pertenecientes a la misma parroquia del Cantón Cuenca, provincia del Azuay, en los meses de Diciembre del 2010 y Marzo del año 2011...

  17. Fitoterapia Mbyá-Guaraní en el control de las parasitosis intestinales. Un estudio exploratorio con Chenopodium ambrosioides L. var. anthelminticum en cinco comunidades de Misiones, Argentina

    Directory of Open Access Journals (Sweden)

    Gabriela Navone

    2015-07-01

    Full Text Available En las comunidades Mbyá-Guaraní, el conocimiento local de las especies vegetales que habitan el “monte” se pone de manifi esto en el desarrollo de distintas actividades tales como su empleo medicinal en las parasitosis y dolencias asociadas. El objetivo de esta contribución fue evaluar la eficacia deChenopodium ambrosioidesL. var.anthelminticum(Ka´aré en el control de las enteroparasitosis. El estudio fue realizado durante septiembre de 1998 y abril de 1999 en las comunidades de Marangatú (MA, Ñamandú (ÑA, El Pocito (PO, Tabay (TB y Takuapí (TA del Departamento Libertador General San Martín, Misiones, Argentina. La muestra incluyó 148 personas que fueron agrupadas por sexo e intervalos etáreos. El tratamiento fitoterapéutico consistió en la administración de tintura de Ka´aré (maceración en alcohol etílico al 70%. El análisis coproparasitológico se realizó mediante examen directo y la técnica de enriquecimiento por flotación (Füllerbon previo y posterior al tratamiento con el Ka´aré. Los resultados indicaron altos porcentajes de individuos parasitados previo al tratamiento (PRET que fluctuaron entre 73.5% y 91.7%. Entre los protozoosEntamoeba colifue la especie más prevalente con porcentajes entre 18.4% y 37.5%.Hymenolepis nanaentre los cestodes presentó prevalencias entre 4.2% y 20.8%. Entre los nemátodosAncylostoma duodenale/Necator americanus(Ancylostomideos fue la más frecuente y su prevalencia fluctuó entre 55.1% y 83.3%.Trichuris trichiurasólo fue observado en ÑA y con una prevalencia muy baja (3.8%. El porcentaje de monoparasitismo fue mayor en ÑA (56.5%, el de biparasitismo en MA y TA (44.4%, mientras que el de poliparasitismo en TB (36.8%. En la evaluación postratamiento (POST la prevalencia total de parasitosis descendió respecto del pretratamiento (79.7% vs 68.9% (X2 Yates = 4.57; p E. coli(30.8%-0.0% y Ancylostomídeos (52.0%-11.5%. Así, en ÑA los Ancylostomídeos mostraron diferencias estadísticamente signifi cativas (73.1% vs. 11.5% (X2 Yates = 8.99; p Ascaris lumbricoidesdescendió en los individuos de todas las comunidades, siendo más evidente en PO (20.8% vs. 0.0% y en ÑA (19.2% vs. 0.0%. ParaGiardia lamblia,H. nanayStrongyloides stercoralisel tratamiento fitoterapeútico no fue efectivo. Respecto al monoparasitismo se observó que sólo disminuyó levemente en TA (44.4% vs. 43.2% y aumentó en el resto de las comunidades, siendo mayor el aumento de monoparasitados en ÑA (56.5% vs. 76.9%. Sin embargo el porcentaje de biparasitismo disminuyó en la mayoría de las comunidades estudiadas, con excepción de TB (36.8% vs. 50.0%. Por último el poliparasitismo descendió sólo en TB (36.8% vs. 11.1% y ÑA (17.4% vs.7.7%. Los resultados obtenidos demostraron la efectividad deCh. ambrosioidesL. var.anthelminticumsobre los Ancylostomideos yA. lumbricoides, mientras que para protozoos, cestodes y larvas deS. stercoralisno fue efectivo.

  18. Retinol, estado del hierro, malaria y parásitos intestinales: relación por medio de las citocinas TH1/TH2

    Directory of Open Access Journals (Sweden)

    Viviana Taylor

    2008-09-01

    Full Text Available Introducción: La malaria, la anemia y la parasitosis intestinal coexisten y constituyen problemas de salud pública en Colombia. Datos disponibles en la literatura biomédica llevan a pensar que estos problemas no son aislados sino que están interrelacionados. Por otra parte, los suplementos de retinol han sido efectivos para reducir la mortalidad infantil, con disminución de complicaciones en niños palúdicos, posiblemente por efectos del retinol sobre la función inmune, desviando la respuesta de citocinas hacia un patrón TH2, que también protege de desarrollar anemia grave. Esta revisión tiene como objetivo describir parte de las relaciones vistas en la literatura biomédica mundial, entre retinol y malaria, retinol y anemia, retinol, malaria y parasitosis intestinal, anemia y malaria y mostrar la mediación de estas interrelaciones por el patrón de citocinas TH1/TH2 en sujetos con malaria.Metodología: Se consultaron las siguientes bases de literatura biomédica: Medline, Lilacs, Spingerlik, Md Consultant, Web of Science, Ovid, Scient Direct, Ebsco y Cochrane. También se buscó información para documentar la prevalencia de desnutrición, deficiencia subclínica de retinol, anemia y malaria en niños colombianos, lo mismo que sobre el papel antinfeccioso del retinol.Resultados: Existe asociación entre parasitosis intestinal y malaria; algunos estudios indican que los helmintos predisponen a contraer malaria en niños. De otro lado, los parásitos mencionados, también se han relacionado con anemia y bajas concentraciones plasmáticas de retinol, que a la vez se asocian con malaria. Sin embargo, no se encontró información que relacione simultáneamente todos estos tópicos y que muestre la respuesta de citocinas TH1/TH2 como la articulación de todos ellos.Conclusiones: Aclarar las múltiples interacciones entre malaria, anemia, parasitosis intestinal y deficiencia subclínica de retinol, teniendo como eje central la respuesta de citocinas TH1/TH2, es crítico para orientar acciones tendientes a su prevención y manejo.

  19. Characterization and pharmacological modulation of intestinal inflammation induced by ionizing radiation; Caracterisation et modulation pharmacologique de l'inflammation intestinale induite par les rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Gremy, O

    2006-12-15

    The use of radiation therapy to treat abdominal and pelvic malignancies inevitably involves exposure of healthy intestinal tissues which are very radiosensitive. As a result, most patients experience symptoms such as abdominal pain, nausea and diarrhea. Such symptoms are associated with acute damage to intestine mucosa including radio-induced inflammatory processes. With a rat model of colorectal fractionated radiation, we have shown a gradual development of a colonic inflammation during radiation planning, without evident tissue injury. This radio-induced inflammation is characterized not only by the sur expressions of pro-inflammatory cytokines and chemokines, a NF-kB activation, but also by a repression of anti-inflammatory cytokines and the nuclear receptors PPARa and RXRa, both involved in inflammation control. This early inflammation is associated with a discreet neutrophil recruitment and a macrophage accumulation. Macrophages are still abnormally numerous in tissue 27 weeks after the last day of irradiation. Inflammatory process is the most often related to a specific immune profile, either a type Th1 leading to a cellular immune response, or a type Th2 for humoral immunity. According to our studies, a unique abdominal radiation in the rat induces an ileum inflammation and an immune imbalance resulting in a Th2-type profile. Inhibiting this profile is important as its persistence promotes chronic inflammation, predisposition to bacterial infections and fibrosis which is the main delayed side-effect of radiotherapy. The treatment of rats with an immuno-modulator compound, the caffeic acid phenethyl ester (C.A.P.E.), have the potential to both reduce ileal mucosal inflammation and inhibit the radio-induced Th2 status. In order to search new therapeutic molecular target, we has been interested in the PPARg nuclear receptor involved in the maintenance of colon mucosal integrity. In our abdominal irradiation model, we have demonstrated that the prophylactic treatment with a PPARg synthetic ligand, the so-called 5-aminosalicylic acid (5-ASA), protects against the development of the acute mucosal colon inflammation. This pharmacological drug restrains radio-induced expression of pro inflammatory molecular actors such as TNFa, MCP-1 and iNOS, it also limits the repression of nuclear receptors involved in inflammation control such as PPARg, and reduces the radio-induced accumulation of macrophages. These results could give some leads to find therapeutic drug to limit radio-induced early mucosal and consequently, to improve patients' comfort during and after the radiotherapy schedule. (author)

  20. Caractérisation de flores microbiennes intestinale humaine et fromagère par méthode de métagénomique quantative

    OpenAIRE

    Almeida, Mathieu

    2013-01-01

    The microbial flora is a micro-organism complex containing for example bacteria, archaea, lower eukaryotes and viruses, which play an important role in ecosystem equilibrium. This flora remains poorly defined as in 2012, only ~30% of the intestinal flora micro-organisms have been characterized, and less than 50% of traditional cheese floras were characterized at the functional level. Since 2006, the second generation of DNA sequencers have allowed the direct analysis of the genetic content fr...

  1. Gènes et absorption intestinale des microconstituants lipidiques (vitamines liposolubles, caroténoïdes et phytostérols*

    Directory of Open Access Journals (Sweden)

    Borel Patrick

    2012-07-01

    Full Text Available Intestinal absorption of lipidic microconstituents (LM is very variable and depends on numerous factors. Recent studies have shown that, contrary to what was assumed, proteins are involved in absorption of LM by enterocyte. It is likely that genetic polymorphisms in genes encoding for these proteins modulate absorption efficiency of these compounds. This hypothesis can explain the huge interindividual variability in absorption efficiency of these compounds. The effect of genetic variants on absorption efficiency of LM may in turn lead to modify plasma and tissues concentration of LM and, finally, their ability to prevent some diseases (cardiovascular diseases, cancers. . .. Recent results support these hypothesis. However, other studies are required to definitely conclude on the real effect of genetic variants of intestinal transporters of LM on status and health effect of these compounds. Since most LM seems beneficial for health at low (dietary doses and can be hazardous at higher (pharmacological doses, it can be anticipated that recommended dietary allowances of LM, or doses of LM in functional foods/supplements, will be adapted to groups of the population carrying common genetic variants known to significantly affect LM bioavailability.

  2. Mécanisme d’absorption intestinale des acides gras à longue chaîne : rôle émergent du CD36

    Directory of Open Access Journals (Sweden)

    Tran Thi Thu Trang

    2012-07-01

    Full Text Available Excessive lipid intake, associated with a qualitative imbalance, favors the development of obesity and associated diseases. From organs involved in the lipid homeostasis, the small intestine remains the most poorly known although it is responsible for the lipid bioavailability and largely contributes to the regulation of postprandial hypertriglyceridemia. The mechanism of long chain fatty acid (LCFA intestinal absorption is not totally elucidated. Over the two last decades, cloning of lipid binding proteins (LBP, proteins involved in trafficking and metabolic fate of LCFA in gut have provided new insights on cellular and molecular mechanisms involved in fat absorption. The synthesis of recent literature indicates that intestine is able to adapt its absorption capacity to the fat content of the diet. This adaptation takes place through a fat-coordinated induction of LBP and apolipoproteins. CD36 could operate as a lipid sensor responsible for a transducing signal related to the lipid content of the diet at the origin of this intestinal adaptation. This lipid-mediated metabolic response may lead to the formation of large chylomicrons rapidly degraded in the blood. All together, these new data indicate that this intestinal lipid sensing mechanism may be a therapeutic target for reducing the postprandial hypertriglyceridemia and associated cardiovascular risks.

  3. Los endocrinológicos: resistencia insulina-déficit secreción, incretinas y hormonas intestinales y microbiota

    OpenAIRE

    Miras, Alexander

    2014-01-01

    There is increasing evidence that metabolic surgery is more effective than diet and exercise for diabetes remission and weight loss. Moreover, the rapid time course and disproportional degree of T2DM improvement after metabolic procedures compared with equivalent weight loss with conservative treatment, suggest surgery-specific, weight-independent effects on glucose homeostasis. Gut hormones has been proposed as one of the potential mechanisms for the weight-independent diabetes remission ...

  4. Comparación de varias técnicas coproparasitológicas para el diagnóstico de geohelmintiasis intestinales

    OpenAIRE

    Núñez-Fernández,Fidel Ángel; Sanjurjo Gonzalez,Esperanza; Villalvilla,Carlos M. Finlay

    1991-01-01

    Se procesan "a ciegas" 511 muestras de heces por las técnicas de Kato-Katz, Willis, Ritchie y directo. Al comparar los resultados obtenidos en el diagnóstico de Trichuris trichiura, Necator americanus y Ascaris lumbricoides, vimos que la de Kato-Katz fué más sensible, revelando el mayor número de casos, siguiéndole en orden sucesivo, el Willis, el Ritchie, y el examen directo. Si se tiene en cuenta que el método de Kato-Katz es además cuantitativo, podemos recomendar-lo como técnica de elecci...

  5. Análisis y aplicación de estrategias para modular la respuesta inflamatoria en patologías intestinales

    OpenAIRE

    Orsini Delgado, María Lucía

    2016-01-01

    Durante las últimas décadas se ha reportado un importante incremento en la incidencia de patologías inmunes inflamatorias, no infecciosas, fundamentalmente en países desarrollados o en vías de desarrollo. Debido a la velocidad con que se ha incrementado la incidencia de estas patologías, sólo los cambios en los factores ambientales son capaces de explicarlo. Estudios epidemiológicos han permitido observar una asociación entre el incremento en patologías inflamatorias no infecciosas y la dismi...

  6. Estudio epidemiológico de las parasitosis intestinales detectadas en la población infantil de Ruanda (África Central)

    OpenAIRE

    Irisarri Gutiérrez, María José

    2016-01-01

    La presente Tesis Doctoral tiene por objetivo conocer el estado del parasitismo intestinal y su correlación con diferentes factores intrínsecos y extrínsecos en la población infantil ruandesa. Para ello, se ha estudiado un total de 674 escolares (330 niños y 344 niñas) del Colegio Nemba I (Nemba, Gakenke, Província Norte de Ruanda), con edades comprendidas entre los 6 y 18 años de edad. Se ha detectado un espectro parasitario de 17 especies (10 de protozoos y 7 de helmintos), con una prevalen...

  7. Effects of yeast extract and vitamin D on turkey mortality and cellulitis incidence in a transport stress model.

    Science.gov (United States)

    We evaluated yeast extract (YE) and vitamin D (VD) in turkeys treated with dexamethasone (Dex) at intervals designed to simulate transport stress during a 3 stage growout. YE but not VD decreased early mortality (P = 0.001) and mortality at wk 7 (P= 0.02) and wk 12 (P = 0.002) but not wk 16. Celluli...

  8. Analisi di costo di pemetrexed vs docetaxel nel trattamento di seconda linea del carcinoma polmonare non a piccole cellule

    Directory of Open Access Journals (Sweden)

    Roberto Ravasio

    2005-06-01

    Full Text Available OBJECTIVES: to compare costs of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy paying special attention to the adverse events. MATERIALS AND METHODS: a cost analysis was carried out performing comparison between pemetrexed and docetaxel. Clinical data (overall survival and resource consumption (chemotherapy drugs, G-CSF, and hospitalizations due to adverse events were obtained from a randomized phase III trial. The economic evaluation was based on direct costs using local Italian unit costs (euro 2005. The perspective was the National Health Service’s. RESULTS: the study results showed that mean survival of pemetrexed (8,3 months; 0,69 years was higher than mean survival of docetaxel (7,9 months; 0,66 years. The mean cost of treatment with pemetrexed was 8.684,26 euros and with docetaxel was 6.182,87 euros. This difference was nearly offset by the difference in the costs of adverse events: the mean cost of adverse events due to chemotherapy treatment with pemetrexed (493,93 euros turned out to be lower than with docetaxel (2.394,34 euros. CONCLUSION: the present cost-analysis could be a stable ground for a further cost-utility analysis, aimed at reaching a more cost-effectiveness management of the chemotherapy-related adverse effects in patients with NSCLC.

  9. Ruolo della Interleuchina-6 nella colite ulcerosa long-standing: regolazione della p53 ed induzione delle cellule mesenchimali epiteliali

    OpenAIRE

    Liguori, Giuseppina

    2013-01-01

    L’infiammazione cronica è un fattore di rischio di insorgenza del cancro, e la citochina infiammatoria IL-6 gioca un ruolo importante nella tumorigenesi. In questo studio abbiamo dimostrato che L’IL-6 down-regola l'espressione e l'attività di p53. In linee cellulari umane, IL-6 stimola la trascrizione dell’rRNA mediante espressione della proteina c-myc a livello post-trascrizionale in un meccanismo p38MAPK-dipendente. L'up-regolazione della biogenesi ribosomiale riduce l'espressione di p53 a...

  10. Etude de la corrosion caverneuse d'un acier inoxydable martensitique : utilisation d'une cellule à couche mince

    OpenAIRE

    Joly Marcelin, Sabrina

    2012-01-01

    Les aciers inoxydables martensitiques sont utilisés dans l'industrie aéronautique où de hautes propriétés mécaniques sont requises. Cependant, dû à leur faible teneur en chrome, ils sont relativement sensibles à la corrosion localisée et particulièrement à la corrosion caverneuse qui se développe en milieu confiné. Tout d'abord, le comportement électrochimique de l'acier inoxydable martensitique X12CrNiMoV12-3 a été étudié dans une solution neutre et chlorurée (NaCl 0,1 M + Na2SO4 0,04 M) en ...

  11. Neurohypophysis granular cell tumours. Upon neurohypophysis rare tumours; Les tumeurs a cellules granuleuses. Des tumeurs rares de la neurohypophyse

    Energy Technology Data Exchange (ETDEWEB)

    Barrande, G.; Kujas, M.; Gancel, A.; Turpin, G.; Bruckert, E.; Kuhn, J.M.; Luton, J.P. [Hopital Cochin, 75 - Paris (France)

    1995-10-01

    Granular cell tumours of neurohypophysis are rare. These tumours are more often encountered as incidental autopsy findings seen in up to 17 % of unselected adult autopsy cases. There are few reports of para-sellar granular cell tumours large enough to cause symptoms. We present three cases of neurohypophysis granular cell tumour and a review of the literature. In one patient, the asymptomatic granular cell tumour was incidentally discovered at surgical removal of a corticotrophic micro-adenoma. The remaining 2 patients had a symptomatic tumour which caused neurological symptoms such as visual disturbance and headaches and endocrine disorders such as hypopituitarism or hyper-prolactinaemia. In these 2 cases, computerized tomography showed a well-circumscribed, contrast-enhanced, intra-sellar and supra-sellar mass. Magnetic resonance imaging demonstrated an isointense gadolinium-enhanced mass in T1-weighted-images. Trans-sphenoidal partial resection was performed and histology was interpreted as a granular cell tumour. The immunohistochemical study was positive for glial fibrillary acidic protein (GEAP) and neuron specific enolase (NSE) in 1 of the 2 tumours and positive for S100 protein and vimentin in both tumours but negative for CD68. The histogenesis of neurohypophysis granular cell tumours is still controversial but ultrastructural and immunohistochemical studies support the theory that may arise from pituicytes, the glial cells of neurohypophysis. Management of these benign, slow growing, tumours is based mainly on neurosurgical resection. Data from the literature do not support a beneficial effect of post operative radiation therapy on postoperative recurrences. (authors). 23 refs., 4 figs., 1 tab.

  12. Cirrhosis, cellulitis and cats: a 'purrfect' combination for life-threatening spontaneous bacterial peritonitis from Pasteurella multocida.

    Science.gov (United States)

    Hey, Penelope; Gow, Paul; Torresi, Joseph; Testro, Adam

    2012-11-11

    Pasteurella multocida is a Gram-negative coccobacillus that colonises the upper airways of many animals, in particular, dogs and cats. It acts as an opportunistic infection in humans following an animal bite or scratch and is associated with soft tissue infections, septicaemia and pneumonia, particularly in patients with a compromised immune response, such as patients with liver failure. Spontaneous bacterial peritonitis (SBP) is a serious complication of cirrhosis with a death rate of 10-15%. We report a case of a 47-year-old man with cirrhosis who presented with life-threatening P multocida SBP and bacteraemia secondary to a lick from a cat to a cellulitic leg wound. This case highlights the potential severity of an infection from domestic animals and an otherwise innocuous organism in an immunocompromised host.

  13. A Homeopathic Arnica Patch for the Relief of Cellulitis-derived Pain and Numbness in the Hand.

    Science.gov (United States)

    Barkey, Elisabeth; Kaszkin-Bettag, Marietta

    2012-05-01

    大拿山金车 (Arnica montana)是一 种菊 (Compositae) 科植物,在用 于缓解肌肉和关节疼痛和/或炎 症方面具有悠久历史,因此有望 成为非甾体类抗炎药的替代品, 而这些非甾体类抗炎药往往效果 不佳或容易导致许多负面作用。 顺势山金车药贴(根据《美国顺 势疗法药典》(Homeopathic Pharmacopoeia of the United States) 3 倍稀释)已开发用于缓解背部和 颈部肌肉及关节疼痛症状。案例简报: 此案例报告描述了一 位 55 岁的女性患者因手掌部位患 蜂窝织炎而出现右手疼痛,第四 指麻痹后,接受山金车药贴治疗 的效果。她曾接受抗生素治疗蜂 窝组织炎,但即使口服布洛芬并 口服及局部外用含山金车的复合 顺势疗法的产品,疼痛症状仍维 持在视觉模拟量表 (visual analog scale, VAS)(将疼痛分为 0 至 10 级)中的 7 级。医生向该患者配发了十张山金车 药贴。她将药贴裁成条状贴在手 上所有疼痛的部位,并在夜间用 药。3 天后,她报告疼痛症状大为 减轻 (VAS = 1) 且麻木的症状和 第三掌骨部位疼痛结节的大小均 显著减小。此外,该患者还能够 彻夜安睡而不被疼醒。在接下来 的 2 天里,症状进一步缓解。 结论: 此案例证实,在患者手上 施用山金车药贴后,经过相对较 短的时间,可显著减轻疼痛并恢 复手部功能。

  14. Cellules solaires avec absorbeur II - VI nanostructuré : matériaux et propriétés

    OpenAIRE

    Salazar, Raùl

    2012-01-01

    The development of semiconducting materials for the extremely thin absorber (eta)solar cell using cheap and scalable methods was the main objective of this work. The eta-solarcell is composed of all inorganic materials consisting of an extremely thin layer of absorbingmaterial (1.1

  15. Helmintos intestinales en aves Ciconiiformes de la ciénaga de Chuburná, Yucatán, México Intestinal helminths of Ciconiiform birds from the Chuburna saltmarsh, Yucatan, Mexico

    Directory of Open Access Journals (Sweden)

    Alfredo O. Barrera-Guzmán

    2008-12-01

    Full Text Available Se recolectaron aves Ciconiiformes en la ciénaga de Chuburná, Yucatán y los intestinos de las aves fueron examinados en busca de parásitos helmintos. En total se encontraron 7 taxa de helmintos: 4 digéneos, 2 nematodos y 1 acantocefalo. Por vez primera se registra para Yucatán el digéneo Cotylotretus grandis y se registran nuevos hospederos para las especies de helmintos Euhaplorchis californiensis y Southwellina hispida, así como para el género Ascocotyle.Ciconiiform birds from the Chuburná saltmarsh, Yucatán were collected and their intestines were examined for helminths. Seven taxa in total were found: 4 digeneans, 2 nematodes and 1 acanthocephalan. The digenean Cotylotretus grandis is registered for the first time for Yucatán. Additionally, there are new host records for the helminth species Euhaplorchis californiensis and Southwellina hispida, and also for the genus Ascocotyle.

  16. Studio dell’espressione dell’Homeobox gene CDX2 nella metaplasia intestinale e nelle lesioni neoplastiche e preneoplastiche dello stomaco e correlazioni clinico-patologiche con l’infezione da Helicobacter Pilory

    OpenAIRE

    2006-01-01

    BACKGROUND: Gastric carcinoma can be divided into the intestinal and diffuse type, or the differentiated and indifferentiated type, on the basis of its tendency to gland formation. Intestinal metaplasia (IM), where intestinal-type carcinoma is thought to develop, is classified into incomplete and complete types. The latter, which resembles small-intestinal absorptive epithelium, has been considered a precancerous lesion, and its development is strongly associated with Helicobacter Pilory (HP)...

  17. Atrophy of the intestinal villi in a post-gastrectomy patient with severe iron deficiency anemia Atrofia de las vellosidades intestinales en un paciente postgastrectomizado con anemia ferropénica grave

    Directory of Open Access Journals (Sweden)

    A. Lizarraga

    2009-10-01

    Full Text Available Background & aims: Iron deficiency anemia is a common complication of gastric surgery that in certain patients can be refractory to treatment with oral iron and needs to be treated parenterally. Methods: A 48-year woman underwent gastric surgery for a gastric ulcer. She was referred to the nutrition unit for the study and treatment of a 3-year iron deficiency anemia refractory to oral iron supplementation. Blood tests, endoscopy and jejunal biopsy were made to study the case. Results: Intestinal villi atrophy in the absence of celiac disease was the result. She was treated with intravenous iron, resolving the villous atrophy and thus oral iron supplementation could be effective. Conclusion: This case illustrates that iron deficiency may cause villous atrophy. In this setting, parenteral iron administration is necessary to correct the haematological and non-hematological alterations associated with this deficiency.Introducción y objetivos: La anemia ferropénica es una complicación frecuente tras la cirugía gástrica que en algunos pacientes puede ser refractaria al tratamiento con hierro oral, siendo necesaria su administración por vía parenteral. Métodos: Presentamos el caso de una mujer de 48 años intervenida de gastrectomía para tratamiento de una úlcera gástrica. Fue remitida a la unidad de nutrición para estudio y tratamiento de una anemia ferropénica de 3 años de evolución refractaria al tratamiento con hierro oral. Para el estudio del caso se realizó analítica y endoscopia digestiva alta con biopsia yeyunal. Resultados: En el estudio realizado la paciente presentaba atrofia de la mucosa yeyunal en ausencia de enfermedad celíaca. Fue tratada con hierro intravenoso desapareciendo la atrofia intestinal, tras lo cual continuamos con suplementos de hierro por vía oral. Conclusión: Este caso ilustra que la deficiencia de hierro puede producir atrofia intestinal. Si esto ocurre, es necesario la suplementación de este metal por vía parenteral para corregir las alteraciones hematológicas y no hematológicas asociadas a esta deficiencia.

  18. Eficacia y mecanismos de acción de bacterias intestinales en alteraciones metabólicas e inmunológicas asociadas a la obesidad y al estrés

    OpenAIRE

    Moya Perez, Angela

    2015-01-01

    El objetivo general de la presente Tesis ha sido analizar la contribución de la microbiota intestinal a la función del sistema inmune, metabolismo, Sistema Nervioso Central y evaluar el efecto de potenciales probióticos en modelos animales de obesidad y ansiedad inducida por estrés. Los objetivos concretos han sido los siguientes: 1. Evaluar la eficacia de Bacteroides uniformis CECT 7771 en un modelo murino de obesidad inducida por la dieta. 2. Identificar el mecanismo de acción d...

  19. Comparación de varias técnicas coproparasitológicas para el diagnóstico de geohelmintiasis intestinales Comparison of several coproparasitological techniques for diagnosis of soil-transmitted helminthiasis

    OpenAIRE

    Fidel Ángel Núñez-Fernández; Esperanza Sanjurjo Gonzalez; Carlos M. Finlay Villalvilla

    1991-01-01

    Se procesan "a ciegas" 511 muestras de heces por las técnicas de Kato-Katz, Willis, Ritchie y directo. Al comparar los resultados obtenidos en el diagnóstico de Trichuris trichiura, Necator americanus y Ascaris lumbricoides, vimos que la de Kato-Katz fué más sensible, revelando el mayor número de casos, siguiéndole en orden sucesivo, el Willis, el Ritchie, y el examen directo. Si se tiene en cuenta que el método de Kato-Katz es además cuantitativo, podemos recomendar-lo como técnica de elecci...

  20. Efecto de la fuente energética y el nivel de energía sobre la longitud de vellosidades intestinales, la respuesta inmune y el rendimiento productivo en pollos de engorda

    OpenAIRE

    Mateo Fabian Itzá-Ortiz; Carlos López-Coello; Ernesto Ávila-González; Sergio Gómez-Rosales; José Arce-Menocal; Pablo Alfonso Velásquez-Madrazo

    2008-01-01

    El objetivo del trabajo fue evaluar el uso de tres fuentes energéticas con diferente perfil de ácidos grasos insaturados (AGI) y saturados (AGS) en dietas para pollos de engorda con dos niveles de energía metabolizable (EM), vacunados o no contra la infección de la bolsa de Fabricio (IBF) y el uso durante todo el ciclo productivo. Se realizaron dos experimentos evaluando la inclusión de las tres fuentes energéticas con distinto perfi l de AGI y AGS que correspondieron al aceite crudo de soya ...

  1. Papel de la cascada del ácido araquidónico en la función epitelial de barrera en un modelo de células intestinales Caco-2

    OpenAIRE

    Rodríguez Lagunas, M. José

    2013-01-01

    [spa] El epitelio intestinal forma una barrera que permite el paso de nutrientes pero restringe el de substancias potencialmente nocivas. La alteración de dicha función se relación a con enfermedades gastrointestinales como la enfermedad inflamatoria intestinal (IBD) en la que, además, la producción de eicosanoides en la mucosa intestinal se encuentra incrementada. Por ese motivo, el objetivo del presente trabajo ha sido investigar el papel de los eicosanoides producidos en la cascada del áci...

  2. {sup 18}F-F.D.G. PET imaging of infection and inflammation: intestinal, prosthesis replacements, fibrosis, sarcoidosis, tuberculosis..; La TEP au {sup 18}F-FDG dans la pathologie inflammatoire et infectieuse: intestinale, prothetique, fibrose, sarcoidose, tuberculose..

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, A.; Cortes, M.; Caresia, A.P.; Juan, R. de; Vidaller, A.; Mana, J.; Martinez-Yelamos, S.; Gamez, C. [Hospital Universitari de Bellvitge, Service TEP-Centre IDI, Services de Medecine Interne, Barcelone (Spain)

    2008-10-15

    Nuclear medicine plays an important role in the evaluation of infection and inflammation. A variety of diagnostic methods are available for imaging this inflammation and infection, most notably computed tomography, {sup 68}Ga scintigraphy or radionuclide labeled leucocytes. Fluorine 18 fluorodeoxyglucose ({sup 18}F-F.D.G.) is a readily available radiotracer that offers rapid, exquisitely sensitive high-resolution images by positron emission tomography (PET). Inflammation can be acute or chronic, the former showing predominantly neutrophilic granulocyte infiltrates, whereas in the latter, macrophages predominate. F.D.G. uptake in infection is based on the fact that mononuclear cells and granulocytes use large quantities of glucose by way of the hexose monophosphate shunts. {sup 18}F-F.D.G. PET accurately helps diagnose spinal osteomyelitis, diabetic foot and in inflammatory conditions such as sarcoidosis and tuberculosis.(it appears to be useful for defining the extent of disease and monitoring response to treatment). {sup 18}F-F.D.G. PET can also help localize the source of fever of undetermined origin, thereby guiding additional testing. {sup 18}F-F.D.G. PET may be of limited usefulness in postoperative patients and in patients with a failed joint prosthesis or bowel inflammatory disease. In this review, we will focus on the role of {sup 18}F-F.D.G. PET in the management of patients with inflammation or suspected or confirmed infection.

  3. Las parasitosis intestinales más frecuentes en la población infantil del área de salud de San Ramón de Alajuela

    Directory of Open Access Journals (Sweden)

    Erasmo Serrano-Frago

    2001-07-01

    Full Text Available Justificación y Objetivo: Las parasitosis intestinal por helmintos y protozoarios continuan teniendo gran impacto en la salud de muchas poblaciones alrededor del mundo. El presente es un estudio para determinar la frecuencia de dichas parasitosis en niños de 1 a 12 años en el área de salud de San Ramón de Alajuela, Costa Rica. Método: Estudio retrospectivo en el que se analizaron muestras de heces de 5250 niños de 1 a 12 años de diciembre de 1999 a noviembre de 2000. Esta población representa cerca de un 29% de la población infantil de 1 a 12 años de la zona, de acuerdo con la población estimada según los compromisos de gestión. Las muestras de heces fueron solicitadas por los médicos tratantes por sospecha de parasitosis intestinal, y a las mismas se les realizó frotis y extendidos simples con la técnica de solución salina y lugol. Se completaron los datos a través de una revisión de expedientes médicos. Resultados: En total un 40.4% de la población estudiada presentó parasitosis intestinal. Se presentaron 1478 casos de protozoarios en las muestras de heces y 645 casos presentaron hallazgo de helmintiasis. Dentro de los protozoarios los más frecuentemente encontrados fueron E. histolytica, E. coli y G. intestinalis. Entre las helmintiasis predominaron la E. vernicularis, S. stercoralisyH. nana. Del total de niñas, 30.7% presentaron parasitosis intestinal contra un 49.7% de los varones. Conclusión: El presente estudio evidencia una disminución en la frecuencia de helmintiasis, la cual seguramente obedece a las campañas masivas que se han hecho, mientras que el incremento en los protozoarios probablemente se deba a que no se ha tomado en cuenta la terapia combinada de antiparasitarios en los protocolos de atención a la población infantil.

  4. Las parasitosis intestinales más frecuentes en la población infantil del área de salud de San Ramón de Alajuela

    Directory of Open Access Journals (Sweden)

    Erasmo Serrano-Frago

    2001-07-01

    Full Text Available Justificación y Objetivo: Las parasitosis intestinal por helmintos y protozoarios continuan teniendo gran impacto en la salud de muchas poblaciones alrededor del mundo. El presente es un estudio para determinar la frecuencia de dichas parasitosis en niños de 1 a 12 años en el área de salud de San Ramón de Alajuela, Costa Rica. Método: Estudio retrospectivo en el que se analizaron muestras de heces de 5250 niños de 1 a 12 años de diciembre de 1999 a noviembre de 2000. Esta población representa cerca de un 29% de la población infantil de 1 a 12 años de la zona, de acuerdo con la población estimada según los compromisos de gestión. Las muestras de heces fueron solicitadas por los médicos tratantes por sospecha de parasitosis intestinal, y a las mismas se les realizó frotis y extendidos simples con la técnica de solución salina y lugol. Se completaron los datos a través de una revisión de expedientes médicos. Resultados: En total un 40.4% de la población estudiada presentó parasitosis intestinal. Se presentaron 1478 casos de protozoarios en las muestras de heces y 645 casos presentaron hallazgo de helmintiasis. Dentro de los protozoarios los más frecuentemente encontrados fueron E. histolytica, E. coli y G. intestinalis. Entre las helmintiasis predominaron la E. vernicularis, S. stercoralisyH. nana. Del total de niñas, 30.7% presentaron parasitosis intestinal contra un 49.7% de los varones. Conclusión: El presente estudio evidencia una disminución en la frecuencia de helmintiasis, la cual seguramente obedece a las campañas masivas que se han hecho, mientras que el incremento en los protozoarios probablemente se deba a que no se ha tomado en cuenta la terapia combinada de antiparasitarios en los protocolos de atención a la población infantil.Background and aim: Intestinal parasitosis by protozoa and helminths, remains a public health problem in many places around the globe. The present study aimes to determine the frequency of these parasitosis in children between 1 and 12 years old in San Ramón, Alajuela, Costa Rica. Method: In this retrospective study 5250 fecal samples of children between 1 and 12 years old were studied. The samples were collected and examined from December 1999 to November 2000. The samples were ordered by the treating physician, in patients whom they suspected as having intestinal parasitosis. The information was obtained from the medical files of each patient. Results: Of the 5250 cases studied 40.4% had parasites in the fecal sample. A majority of the cases corresponded to protozoa (1478 samples, and 645 samples were positive for helminths. Among the protozoa found the most frequent ones were E. histolytica, E. coli yG. intestinalis. Among the helminths E. vernicularis, S. stercoralisand H. nana were the most frequent ones. With regard to sexdistribution 30.7% of the girls had parasitosis compared to 49.7% of the boys. Conclusion: Intestinal parasitic infection remains highly frequent among the pediatric population. There has been a reduction in the frequency of helminths due to massive control campaigns. However, protozoa have emerged due to a lackof combined antiparasitic therapy in these campaigns.

  5. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    Science.gov (United States)

    Teubner, Wera

    2001-05-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen Formen in allen Proben ähnlich. In wenigen Proben waren die relativen Signalintensitäten der h1A1 und der h1B1 um die Hälfte erniedrigt. Der Gehalt von SULT an zytosolischem Protein zeigte einen bis zu 8 - 10fachen Unterschied, er betrug jedoch bei zwei Dritteln der Proben zwischen 0,15 und 0,3 (h1A1 und h1A3) bzw. 0,6 und 0,8 Promille (h1B1). Die Variation konnte nicht auf Alter, Geschlecht oder Krankheitsbild der Patienten zurückgeführt werden. Auch der für die allelischen Varianten der h1A1 beschriebene Effekt auf die Enzymaktiviät bzw. Stabilität konnte in der Menge an immunreaktivem Protein nicht in diesem Ausma detektiert werden. Die Allelhäufigkeit von h1A1*R und h1A1*H war gegenüber der gesunden Bevölkerung nicht verändert. In den sieben Proben aus dem Dünndarm (Coecum, viermal Ileum, Jejunum) konnten zusätzlich die Formen h1E1 und h2A1 identifiziert werden. Ein möglicherweise der Form h1C1 entsprechendes Protein wurde im Magen detektiert. Im Vergleich zum Menschen war die Expression in der Ratte stärker auf die Leber konzentriert. Während beim Menschen in allen untersuchten Abschnitten Sulfotransferasen in Mengen detektiert wurden, die in zwei Fällen (h1B1 und h1A3) sogar den Gehalt in der Leber überstiegen, beschränkte sich die Expression in der Ratte auf im Vergleich zur Leber geringe Mengen im Magen und Dickdarm. Nachgewiesen wurden die r1B1, r1A1 sowie eine nicht identifizierte Form von 35kD, bei der es sich vermutlich um die r1C2 handelt. Im Vergleich zur Leber enthielt der Dickdarm der Ratte 20 - 30 % an r1B1 und 3 % an r1A1, während im Dickdarm des Menschen die 3 - 5fache Menge an h1B1 und 25 - 50 % an h1A1 gefunden wurden. Die nicht identifizierte Form verhielt sich wie die r1B1. Die für die Leber der Ratte bekannte geschlechtsabhängige Expression wurde im Gastrointestinaltrakt nicht beobachtet. Die Verteilung der Sulfotransferasen im Colon und Ileum des Menschen wurde immunhistochemisch untersucht; für die Gewebe der Ratte war die Spezifität der zur Verfügung stehenden Antiseren nicht ausreichend. Im Colon traten h1B1-spezifische Färbungen in den differenzierten Enterozyten am oberen Ende der Krypten auf, im Dünndarm wurden die Epithelzellen der Zotten gefärbt. Die Färbung konzentrierte sich auf das Zytoplasma. Eine ähnliche Verteilung zeigte sich für h1A1 und h1A3, auer da zusätzlich eine intensive Färbung der Endothelzellen der Kapillaren in der Submukosa des Ileums auftrat. Im Dickdarm war dies nur bei den Kapillaren in den Lymphfollikeln zu erkennen. Die h2A1 war lediglich im Zytoplasma der Epithelzellen der Zotten des Ileums nachzuweisen, während im Colon keine Farbreaktion auftrat. Durch die Verwendung der rekombinanten Indikatorstämme TA1538-h1A1, -h1A3 und -h1B1 und des Ausgangsstammes Salmonella typhimurium TA1538 im Ames-Test wurde gezeigt, da verschiedene benzylische und allylische Alkohole durch im humanen Colon exprimierte Sulfotransferasen zu Mutagenen aktiviert werden. In den meisten Fällen erwies sich eine der drei Sulfotransferasen als besonders effizient in der Bioaktivierung, während durch die anderen Formen kein oder nur ein schwacher Effekt verursacht wurde. Die Bioaktivierung von Promutagenen durch Sulfotransferasen im Colon mu im Zusammenhang mit der Lokalisation diskutiert werden. Die Zellen im Darm, in denen immunhistochemisch Sulfotransferasen detektiert wurden, haben mit Ausnahme des Endothels je nach Abschnitt eine Lebensdauer von maximal fünf Tagen und machen keine weiteren Zellteilungen mehr durch. Daher sind DNA-Schäden in diesen Zellen ein sehr geringes Risiko für den Organismus. Soweit die reaktiven Metabolite in diesen Zellen gefangen bleiben, kann die Bioaktivierung in diesen Zellen und die Bildung von Addukten als protektiv betrachten werden, da letztere nach wenigen Tagen mit den toten Zellen in das Darmlumen abgegeben werden. Für den Vergleich der Bioaktiverung von Promutagenen durch die Form 1B1 des Menschen und der Ratte wurden aus V79 Lungenfibroblasten des Chinesischen Hamsters abgeleitete Zellinien hergestellt, die je eine der beiden Formen stabil exprimieren. Damit standen 1B1-profiziente Indikatorzellen für den HPRT-Genmutationstest zur Verfügung, und die 1B1-abhängige Bioaktivierung konnte in einem System untersucht werden, die dem eukaryontischen Organismus näher steht als die für die Ames-Tests verwendeten Bakterien. So war z.B. die Sulfotransferase wie im Gewebe im Zytoplasma lokalisiert. Als Modellsubstanzen wurden hierbei die bereits in TA1538-h1B1 mutagen wirkenden benzylischen Alkohole 6-Hydroxymethylbenzo[a]pyren und 4-Hydroxycyclopenta-[def]chrysen getestet. Da die Sensitivität einer Sulfotransferase-exprimierenden V79-Zellinie sowohl durch die Menge an Sulfotransferase als auch durch die Verfügbarkeit des Sulfodonors limitiert sein könnte, wurden die Mutagenitätsexperimente mit V79-r1B1-Zellinien durchgeführt, die sich in ihrer Enzymaktivität um das Zwanzigfache unterschieden: V79-r1B1/A und -/B. Eine starke Erhöhung der Mutantenfrequenz wurde nur in der hoch exprimierenden Zellinie V79-r1B1/A (1019 ± 224 pmol/mg/min) beobachtet, so da eine gravierende Beeinträchtigung der Sensitivität durch einen Mangel an Kosubstrat ausgeschlossen wurde. In der niedriger exprimierenden Zellinie V79-r1B1/B (57 ± 9 pmol/mg/min) war nur mit 6-Hydroxymethylbenzo[a]pyren ein schwacher Anstieg der Mutantenfrequenz zu erkennen, der mit 0,3 µM bei einer in etwa 100fach höheren Konzentration begann als bei V79-r1B1/A. Die zytosolische Fraktion aus V79-r1B1/B-Zellen enthielt in etwa die dreifache Menge an r1B1-Protein wie die aus Colonmucosa der Ratte. Da zumindest für die humane Mukosa gezeigt wurde, da die 1B1 nur im einschichtigen Epithel, nicht aber in allen Zellen der Mukosa exprimiert wird, repräsentiert die zytosolische Fraktion aus der Mukosa nur bedingt die Expression in den Epithelzellen und der Vergleich mit den V79-1B1-Zellen ist grob. Im Gegensatz zu V79-r1B1/B war die Zellinie V79-h1B1, die ebenfalls nur mit Darm und Leber vergleichbare Mengen an h1B1 exprimierte, in der Lage, beide benzylischen Alkohole zu aktivieren. Der Erhöhung der Mutantenfrequenz im Vergleich zur KontrollZellinie war ähnlich wie bei der stark exprimierenden Zellinie V79-r1B1/A, erforderte aber 10fach höhere Konzentrationen. Somit unterscheiden sich Mensch und Ratte nicht nur insgesamt in ihrer Ausstattung des Gastrointestinaltrakts mit Sulfotransferasen, auch bei Betrachtung einer einzelnen Form zeigten sich deutliche Unterschiede in der Aktivierung von zwei Promutagenen. Die Ratte ist daher ein ungeeignetes Modell, um die Rolle von Sulfotransferasen bei tumorinitiierenden Prozessen im Darm zu untersuchen. Dies unterstreicht die Bedeutung von rekombinanten in-vitro-Systemen für die Erfassung des humanen Metabolismus von Fremdstoffen. Insgesamt kennt man nur eine geringe Anzahl von Substanzen, die im Tierexperiment Colontumore erzeugen, und mit Ausnahme der heterozyklischen aromatischen Amine sind diese lediglich von experimenteller Bedeutung. Dies spricht für effiziente Schutzmechanismen der Darmmukosa gegenüber Mutagenen und lät die Frage nach der hohen Inzidenz des Kolorektalkarzinoms offen. Cytosolic fractions of human and rat gastro-intestinal mucosa were electrophoresed, blotted and probed with six antibodies with differing specificities for sulfotransferase (SULT) forms. Using SULTs heterologously expressed in bacteria for comparison of electrophoretic and immunoreactive properties the following SULTs could be identified in the different parts of the human (h) gastro-intestinal tract: h1A1, h1A3 and h1B1 were detected in all parts analyzed (rectum, colon, caecum, ileum, jejunum, stomach), h1E1 and h2A1 only in the small intestine and h1C1 only in stomach. The presence of h2A1 and h1E1 in the small intestine was also confirmed by enzyme activity measurements using radiolabelled dehydroepiandrosterone and b-estradiol as substrates. SULTs were detected in almost all of the samples analyzed (rectum: 8 of 8, colon: 22 of 23, ileum 5 of 5 and one each of coecum, jejunum and stomach). The colon sample void of SULT protein was the only one taken from a patient suffering from ulcerative colitis. Using an antibody which crossreacts with all human SULT1 forms, a similar pattern of immunoreactivity was observed for all positive samples of rectum and colon mucosa. However, the total amount of immunoreactive protein varied 8 - 10 fold. SULT content in two thirds of the samples was between 0.15 and 0.3 ‰ (h1A1 and h1A3) and 0.6 and 0.8 ‰ (h1B1). This variation could neither be related to age, gender nor disease. The distribution of the allelic variants h1A1*Arg and h1A1*His was analyzed by restriction fragment length polymorphism and the allele frequency in patients suffering from colorectal carcinoma (n = 39) was found not to differ from the values published for normal population. The reduced enzyme activity and stability that has been described for h1A 1*His in platelats was not reflected in the amount of h1A1 protein in the samples of colon and rectum mucosa. Expression of h1A1 and h1A3 was approximately four times higher in ileum than in colon, whereas amounts of h1B1 were comparable in both parts of the intestine. Some of these forms were also expressed at similar, or higher levels in the liver. However, the level of h1B1 protein was higher in the gut than in the liver, and h1A3 was hardly expressed in liver. In rat (r), unlike human, SULTs were poorly expressed in the intestine. r1B1 and an unidentified immunoreactive protein of 35kD were found in the large intestine (rectum, colon, coecum), the proximal jejunum and glandular stomach. r1A1 protein was detected in the large intestine and forestomach. However, the highest levels of these forms in the intestine reached only 3% (r1A1) and 20% (r1B1 and 35kD-protein) of those detected in liver. Unlike in liver, SULT expression in the intestine was independent on gender. Immunohistochemical analysis of human colon and ileum using antibodies specific for either h1B1, h2A1 or all forms of h1A showed that all forms were expressed in the cytosol of the short-lived absorptive cells. In ileum, expression was restricted to villus cells with no staining of crypt cells; except for h1A forms, which were also detected in the endothelial cells of capillaries in the submucosa. In colon, h1B1 and h1A forms, but not h2A1 were detected in the upper third of the crypts. Sensitivities of the antibodies were insufficient for analysis of rat intestine. As 1B1 was the most prominent form in the intestine of both species, Ames tests and hprt gene mutation assays were performed using indicator cells constructed for heterologous expression of 1B1. 6-Hydroxymethylbenzo[a]pyrene and 4-hydroxycyclo-penta[def]chrysene were detected as strong mutagens in Salmonella typhimurium TA1538-h1B1 but neither in the SULT-deficient parental strain nor in bacteria expressing h1A1 or h1A3. Other benzylic or allylic alcohols were mutagenic in Salmonella typhimurium TA1538-h1A1 or h1A3, but not in the h1B1-expressing strain. For the mammalian system, one cell line with high 1B1 activity as determined by turnover of a-naphthol at 1µM and two cell lines with lower activity were established: V79-r1B1/A (1019 ± 224 pmol/mg/min), V79-r1B1/B (57 ± 9 pmol/mg/min) and V79-h1B1 (19 ± 5 pmol/mg/min). 1B1 expression in cytosolic fractions was comparable to rat liver and human colon for V79-r1B1/B and V79-h1B1 respectively. Subcellular distribution was analyzed by immunostaining of cultured cells fixed with methanol. Strong staining of the cytosol was observed in most, but not all of the V79-r1B1/A cells. No staining was observed in V79-r1B1/B, V79-h1B1 or the parental V79 cells. In all cell lines, expression was stable over at least 25 passages and could be detected after 24, 48 and 72 h of cultivation. Population doubling times were 13,1 ± 0.6 h for V79-h1B1 (n = 4), 14.1 ± 1.3 h for V79-r1B1/A (n = 6) and 14.1 ± 1.7 h (n = 3) for V79-r1B1/B. 6-Hydroxymethylbenzo[a]pyrene and 4-hydroxycyclopenta[def]chrysene were detected as strong mutagens in V79-1B1 cells, but not in SULT-deficient control cells. The effect was strong in V79-r1B1/A and V79-h1B1, but weak and occurring at higher concentrations in V79-r1B1/B. Comparing immunoreactivity in cytosolic fractions and fixed cells, h1B1 was expressed more strongly in colonic epithelial cells than in V79-h1B1. It is therefore probable that the compounds tested are also activated in the human gut; however, due to the cellular localization of the enzyme, differentiated cells may be affected primarily. Since these cells are discarded into the gut lumen after a few days and do not undergo further cell divisions, the risk of causing mutations should be low. This mechanism may lead to a presystemic elimination of dangerous compounds. For the study of SULT1B1 mediated mutagenicity in human intestine, rat is a poor model since rat 1B1 was much less capable of activating the benzylic alcohols and was also found to be present in this organ in lower amounts than the human form.

  6. L'autonomie comme capacité d'action : Une expérience de cellules autonomes dans l'aéronautique

    OpenAIRE

    Bercot, Régine

    1999-01-01

    L'activité au sein des équipes autonomes peut être définie comme processus interactif qui permet d'élargir et diversifier le champ d'intervention, développer la responsabilité individuelle et collective au sein du groupe. Pour traiter de la conquête d'autonomie dans un nouveau cadre organisationnel, nous nous centrons sur l'analyse du processus de mise en place des équipes autonomes. Nous en décrivons le processus de mise en place. Ce processus se joue sur un plan politique ; répondre ou non ...

  7. Mechanisms of mutagenesis in mammalian cells. Application to human thyroid tumours; Mecanismes de mutagenese dans les cellules de mammifere. Le modele des tumeurs thyroidiennes humaines

    Energy Technology Data Exchange (ETDEWEB)

    Sarasin, A.; Bounacer, A.; Lepage, F.; Guillermo Suarez, H. [Institut de Recherches Scientifiques sur le Cancer, 94 - Villejuif (France). Laboratoire de Genetique Moleculaire, UPR 42 CNRS; Schlumberger, M. [Institut Gustave Roussy, 94 - Villejuif (France). Service de Medecine Nucleaire

    1999-03-01

    Mutations are defined as stable and irreversible modifications of the normal genetic message due to small changes in the number or type of bases, or to large modifications of the genome such as deletions, insertions or chromosome rearrangements. These lesions are due to either polymerase errors during normal DNA replication or unrepaired DNA lesions, which will give rise to mutations through a mutagenic pathway. The molecular process leading to mutagenesis depends largely on the type of DNA lesions. Base modifications, such as 8-oxo-guanine or thymine glycol, both induced by ionizing radiations (IR), are readily replicated leading to direct mutations, usually base-pair substitutions. The 8-oxo-G gives rise predominantly to G to T transversions, the type of mutations found in ras or p53 gene from IR-induced tumors. Bulky adducts produced by chemical carcinogens or UV-irradiation are usually repaired by the nucleotide excision repair (NER) pathway which is able to detect structural distortion in the normal double-strand DNA backbone. These lesions represent a blockage to DNA and RNA polymerases as well as some signal for p53 accumulation in the damaged cell. In the absence of repair, these lesions could be eventually replicated owing to the induction of specific proteins at least in bacteria during the SOS process. The precise nature of the error-prone replication across an un-excised DNA lesion in the template is not fully understood in detailed biochemical terms, in mammalian cells. IR basically produce a very large number of DNA lesions from unique base modifications to single- or double-strand breaks and even complex DNA lesions due to the passage of very high energy particles or to a local re-emission of numerous radicals. The breakage of the double-helix is a difficult lesionto repair. Either it will result in cell death or, after an incorrect re-combinational pathway, it will induce frame-shifts, large deletions or chromosomal rearrangements. Most of the IR-induced mutations are recessive ones, requiring therefore a second genetic event in order to exhibit any harmful effect and a long latency period before the development of a radiation-induced tumor. The fact that IR essentially induce deletions and chromosomal translocations renders very difficult the use of the p53 gene as a marker for mutation analysis. In agreement with the type of lesions induced by IR, it is interesting to point out that the presence has been observed, in a vast majority of radiation-induced papillary thyroid carcinomas (PTC), of an activated ret proto-oncogene originated by the fusion of the tyrosine kinase 3' domain of this gene with the 5' domain of four different genes. These ret chimeric genes which are due to intra- or inter-chromosomal translocations, were called RET/ PTC1 to PTC5. The RET/PTC rearrangements were found in PTC from children contaminated by the Chernobyl fall-out as well as in tumours from patients with a history of therapeutic external radiation, with a frequency of 60-84 %. This frequency was only 15 % in 'spontaneous' PTC. The type of ret chimeric gene predominantly originated by the accidental or therapeutic IR was different. Indeed, PTC1 was present in 75 % of the tumours linked to a therapeutic radiation and PTC3 in 75 % of the Chernobyl ones. The other forms of RET/PTC were observed in only a minority of the post-Chernobyl PTC (< 20 %). The difference in the frequency of PTC1 and PTC3 in both types of PTC, is statistically significant (p < 10{sup -5}, Fischer's exact test). In two of the post-therapeutic radiation PTC, RET/PTC1 and PTC3 were simultaneously present. A PTC1 gene was also observed in 45 % of the adenomas appearing after therapeutic radiation. The long period of latency between exposure to IR and the appearance of thyroid tumours is probably due to the conversion ofa heterozygote genotype of IR-induced mutations to a homozygote one. It will be interesting to use this time lag in accidental or therapeutic-irradiated patients, to apply anti-promoter agents leading eventually, to a lower level of tumorigenesis. (authors)

  8. Electrode transparente en nanofils d’argent : intégration dans les cellules et modules photovoltaïques organiques sur substrat souple

    OpenAIRE

    Laurans, Gildas

    2016-01-01

    An organic photovoltaic (OPV) cell consists of a thin-layer stack which includes a transparent electrode, usually made of indium tin-doped oxide (ITO). Alternative, indium-free materials, deposited in air with a wet deposition process on large, flexible substrates that are more compatible with the OPV field are currently widely investigated. Silver nanowires (Ag NWs), which represent a serious candidate to replace ITO, are the subject of this thesis. In this work a method to deposit Ag NWs on...

  9. CEA develops organic photovoltaic cells that might replace silicon cells; La promesse du plastique. Le CEA developpe des cellules photovoltaiques organiques qui pourraient detroner le silicium

    Energy Technology Data Exchange (ETDEWEB)

    Donnars, O.

    2003-01-01

    The program ''plastic photovoltaic solar cells'' was launched in june 2002 at LCOF (laboratory of functional organic components - CEA). The aim of this program is to show the feasibility of efficient organic photovoltaic cells. At the moment the most efficient organic cells reach a conversion rate of 3,5 % compared to the average value of 16 % for silicon cells. This program sets a term of 4 years to reach a conversion rate of 5 % and an operating life of 5000 hours. Plastics (or polymers) are less expensive than silicon, are available on an unlimited basis and are environment friendly. Plastics are easy to handle and a sole technology (serigraphy) is necessary for all the stages of the fabrication process of the organic cells: serigraphy technology is used for the deposition of the substrate, of the material in which the conversion takes place, and of the protective skin. (A.C.)

  10. Mesenchymal stem cells favour healing of the cutaneous radiation syndrome; Les cellules souches mesenchymateuses favorisent la cicatrisation des lesions cutanees radio induites

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Mathieu, N.; Semont, A.; Monti, P.; Dudoignon, N.; Sache, A.; Boutarfa, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [IRSN, Dir. de radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France)

    2006-10-15

    It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immuno-deficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a {sup 60} Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immuno-histology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy. (authors)

  11. Merkel cell carcinoma: Outcome and role of radiotherapy; Carcinome a cellules de Merkel: prise en charge et place de la radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Salvador Alonso, R.; Lahbabi, I.; Ben Hassel, M.; Boisselier, P.; Crevoisier, R. de [Centre Eugene-Marquis, Dept. de Radiotherapie, 35 - Rennes (France); Chaari, N. [Institut Gustave-Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); Lesimple, T. [Centre Eugene-Marquis, Dept. d' Oncologie Medicale, 35 - Rennes (France); Chevrier, S. [Centre Hospitalier Prive de Saint-Gregoire, Dept. de Chirurgie Plastique, 35 - Saint-Gregoire (France)

    2008-09-15

    Merkel cell carcinoma (M.C.C.) are rare neuroendocrine malignant tumor of the skin, occurring in elderly patients. It affects primarily the sun-exposed areas of the skin, with approximately 50% of all tumors occurring in the face and neck and 40% in the extremities. Immunohistochemical markers (C.K.20+, C.K.7- and T.T.F.1-) are used to distinguish between M.C.C. and other tumors. M.C.C. have a tendency to rapid local progression, frequent spread to regional lymph nodes and distant metastases. Due to the rarity of the disease, the optimal treatment has not been fully defined. Localized stages (stages I and II) are treated by surgical excision of the primary tumor (with 2 to 3 cm margin) and lymphadenectomy in case of node-positive disease, followed by external beam radiotherapy (E.B.R.T.) to a total dose of 50 to 60 Gy in the tumor bed. Adjuvant E.B.R.T. has been shown to decrease markedly locoregional recurrences and to increase survival in recent studies. Treatment of lymph nodes area is more controversial. Chemotherapy is recommended only for metastatic disease. (authors)

  12. Treatment of radioinduced skin burns by adult stem cells;Traitement des brulures cutanees radio-induites par cellules souches adultes

    Energy Technology Data Exchange (ETDEWEB)

    Lataillade, J.J.; Prat, M. [Hopital Militaire Percy, Centre de Transfusion Sanguine des Armees, Dept. Recherches et Therapies Cellulaires, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Bey, E. [Hopital Militaire Percy, Service de Chirurgie Plastique, 92 - Clamart (France)

    2009-12-15

    In the area of skin injuries caused by ionizing radiations; the recent opportunity give us the the possibility to manage victims of radiation accidents with skin acute symptoms of irradiation. The approach of cell therapy developed for these patients could be in a second time, used for other types of injuries as thermal burns and the injuries linked to overexposure in radiotherapy. In spite of the diversity of approaches of allogeneic and autologous transplantation, the prognosis of deep and extended radioinduced burns is not completely satisfying because of inflammatory recurrences, origin of graft failures. The stem cells have been used in association. The stem cells were got from sampling of autologous bone marrow after an expansion in vitro from 15 to 17 days. The cultures were realised in medium with 8% of platelet lysate (clinical grade). The cells have been given by injection in complement of epidermis auto graft. A spectacular effect was noticed the day after the injection, but disappearing in some days encouraging to realize supplementary injections. An effect of the quickness and the quality of the graft success is appeared significant too. no necrosis recurrence for the patients after four years for the first one of them. We think that the stem cells participate to the local control of inflammation. (N.C.)

  13. Influence de l’hypoxie sur la susceptibilité des cellules tumorales à la lyse induite par les lymphocytes T cytotoxiques

    OpenAIRE

    2012-01-01

    Hypoxia is a common feature of solid tumors and one of the hallmarks of tumor microenvironment. Tumor hypoxia plays an important role in angiogenesis, malignant progression, metastatic development, chemo-radio resistance and favours immune evasion by the emergence of tumor variants with increased survival and anti-apoptotic potential. There is very little work done on the impact of tumor hypoxia on the regulation of tumor susceptibility to the lysis induced by cytotoxic antitumor response. Th...

  14. New method of determining the thermal utilization factor of a cell; Nouvelle methode de determination du facteur d'utilisation thermique d'une cellule

    Energy Technology Data Exchange (ETDEWEB)

    Amouyal, A.; Benoist, P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1956-07-01

    A new formula for the thermal utilization factor is derived, which, while comparable in simplicity to the formula given by elementary diffusion theory, furnishes much more precise results. This is clearly brought out by comparison with the results given by the S{sub n} and spherical harmonics methods. (author) [French] Une nouvelle expression du facteur d'utilisation thermique, d'une simplicite comparable a celle de Ia theorie elementaire, est etablie. La comparaison avec les resultats fournis par la methode S{sub n} et les methodes d'harmoniques spheriques montre que la precision obtenue par cette formule est tres superieure a celle que donne la theorie elementaire. (auteur)

  15. Simulation, elaboration and analysis of inter-digitated back-contacts photovoltaic cells; Simulation, fabrication et analyse de cellules photovoltaiques a contacts arrieres interdigites

    Energy Technology Data Exchange (ETDEWEB)

    Nichiporuk, O

    2005-05-15

    Solar energy is the most promising and powerful energy source among renewable energies. Photovoltaic electricity is obtained by direct transformation of the sunlight into electricity by means of photovoltaic cells. The objective of this work is to develop photovoltaic cells with back inter-digitated contacts. In the first chapter, we recall the principle of operation and the fundamental parameters of a photovoltaic cell. In a second part, we explain specificities of the inter-digitated back-contact solar cells, as well as the advantages and the disadvantages of such cells. In the second chapter we study the operation of inter-digitated back-contacts solar cells by two dimensional numerical simulation in order to optimize the geometry and doping profiles of the cell. The third chapter relates to the techniques and the methods of characterization of photovoltaic devices and components. In the fourth chapter, we describe the elaboration of inter-digitated back-contact cells. Three technological processes are presented in order to develop a simple technology for cells realization. In particular, we develop the auto-aligned technological process, which enables to elaborate the cells by using only one lithography step. In the last chapter we examine various approaches to reduce the surface recombination: SiO{sub 2}, silicon nitride deposited by UVCVD, hydrogen annealing, etc... (author)

  16. Simulation, elaboration and analysis of inter-digitated back contacts photovoltaic cells; Simulation, fabrication et analyse de cellules photovoltaiques a contacts arrieres interdigites

    Energy Technology Data Exchange (ETDEWEB)

    Nichiporuk, O

    2005-05-15

    Solar energy is the most promising and powerful energy source among renewable energies. Photovoltaic electricity is obtained by direct transformation of the sunlight into electricity by means of photovoltaic cells. The objective of this work is to develop photovoltaic cells with back inter-digitated contacts. In the first chapter, we recall the principle of operation and the fundamental parameters of a photovoltaic cell. In a second part, we explain specificities of the inter-digitated back-contact solar cells, as well as the advantages and the disadvantages of such cells. In the second chapter we study the operation of inter-digitated back-contacts solar cells by two dimensional numerical simulation in order to optimize the geometry and doping profiles of the cell. The third chapter relates to the techniques and the methods of characterization of photovoltaic devices and components. In the fourth chapter, we describe the elaboration of inter-digitated back-contact cells. Three technological processes are presented in order to develop a simple technology for cells realization. In particular, we develop the auto-aligned technological process, which enables to elaborate the cells by using only one lithography step. In the last chapter we examine various approaches to reduce the surface recombination: SiO{sub 2}, silicon nitride deposited by UVCVD, hydrogen annealing, etc.. (author)

  17. Study on the improvement of the reliability of solar cells on polymer substrates; Etude et amelioration de la fiabilite des cellules solaires sur substrats polymeres

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D.; Ziegler, Y.; Closset, A.

    2004-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) presents the results of work done on the improvement of the long-term reliability of flexible solar cells deposited on polyimide substrates. Several possibilities were explored simultaneously, including vacuum-de-gassing of the polyimide film, the prevention of water absorption by using diffusion barriers and the reduction of mechanical stress in the thin silicon layers. Work completed is described, including the adaptation of the deposition system, the structuring of metal coatings and improvements to existing equipment to reduce defects caused by dust. The continual effort being made to stabilise the production process and make it economically viable is noted.

  18. Oocyte-somatic cell communication and microRNA function in the ovary: Communication ovocyte-cellule somatique et fonction des microRNA dans l’ovaire

    OpenAIRE

    2010-01-01

    An enormous amount of knowledge about the ovary has been generated over the last two decades, due in part to the development of strategies to genetically manipulate the mouse using embryonic stem cell technology. Our group and others have identified multiple factors that are important and essential at all stages of ovarian folliculogenesis from formation of the primordial factor to ovulation. It is obvious that an oocyte, the key cargo of the ovary, and the surrounding granulosa cells, the su...

  19. Report of a rare case of sepsis caused by Bacillus pumilus in an immunocompetent child with the involvement of soft tissues cellulitis

    Directory of Open Access Journals (Sweden)

    Libera Clemente

    2016-12-01

    Full Text Available Bacillus pumilus is an environmental contaminant, rarely associated with human diseases. In this report we describe a case of a severe sepsis caused by B. pumilus in a 7-year-old healthy child. The microorganism has been isolated from two blood cultures and has been identified using both biochemical tests and mass spectrometry. The patient fully recovered after an ampicillin treatment.

  20. Lemierre's syndrome due to community-acquired meticillin-resistant Staphylococcus aureus infection and presenting with orbital cellulitis: a case report

    Directory of Open Access Journals (Sweden)

    Kadhiravan Tamilarasu

    2008-12-01

    Full Text Available Abstract Introduction Lemierre's syndrome is septic thrombophlebitis of the internal jugular vein leading to metastatic septic complications following an oropharyngeal infection. It is usually caused by the anaerobe, Fusobacterium necrophorum. Of late, meticillin-resistant Staphylococcus aureus is increasingly being recognised as a cause of community-acquired skin and soft tissue infections. We report a rare case of Lemierre's syndrome caused by community-acquired meticillin-resistant Staphylococcus aureus infection. Case presentation A previously healthy 16-year-old girl presented with fever of 13 days duration, painful swelling around the right eye and diplopia followed by the appearance of pulmonary infiltrates. Imaging studies confirmed the clinical suspicion of bilateral jugular venous thrombosis with septic pulmonary embolism. Meticillin-resistant Staphylococcus aureus was isolated on blood cultures. The hospital course was complicated by massive haemoptysis and pulmonary aspiration necessitating mechanical ventilation. The patient subsequently made a complete recovery. Conclusion Lemierre's syndrome, although rare, is a potentially lethal but treatable complication of head and neck sepsis. Early clinical recognition of Lemierre's syndrome and appropriate antibiotic treatment can be life-saving. One should consider the possibility of community-acquired meticillin-resistant Staphylococcus aureus infection in patients with suspected Lemierre's syndrome.

  1. Targeted therapies and radiation therapy in non-small cell lung cancer; Therapies ciblees et radiotherapie dans les cancers bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, S.; Quero, L.; Wong Hee Kam, S.; Maylin, C.; Hennequin, C. [Service de cancerologie radiotherapie, hopital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris (France); Deutsch, E. [UMR 1030 ' radiosensibilite des tumeurs et tissus sains ' , Inserm, 114, rue edouard-Vaillant, 94805 Villejuif (France); Departement de radiotherapie, institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif (France)

    2011-10-15

    Lung cancer is the leading cause of cancer-related death. Between 80-85% of lung cancers are non-small cell lung carcinomas. One third of the patients are diagnosed with locally advanced stage. In this condition, concomitant radio-chemotherapy is the standard treatment for patients with good performance status. Despite important improvements in the last years, non-small cell lung carcinoma prognosis remains poor, with high rates of both local recurrences and metastases. The heterogeneity of molecular characteristics of non-small cell lung carcinoma cells and a better knowledge of potential targets offer promising developments for new pharmacologic agents. Hereafter we will review the currently most studied pathways and the most promising ones for the treatment of locally advanced unresectable non-small cell lung carcinoma. Two of the most attractive pathways where new agents have been developed and assessed in combination with thoracic radiotherapy or radio-chemotherapy are the EGFR pathway (either with the use of monoclonal antibodies or tyrosine kinase inhibitors) and the angiogenesis inhibition. The development of targeted agents could lead to individualized therapeutic combinations taking into account the intrinsic characteristics of tumor cells. Pharmacological modulation of tumour cells radiosensitivity by targeted therapies is only starting, but yet offers promising perspectives. (authors)

  2. Champ dynamique dans une cellule d'échangeur à vortex : 1. Régime d'entrée laminaire

    Science.gov (United States)

    Petitot, Stéphane; Lyazid, Abdel; Devienne, René

    Numerical simulation and LDV measurements are performed for laminar inlet flow condition in a vortex exchange chamber with isothermal conditions. Newtonian and non-Newtonian fluids were used. Experimental measurements are compared to results of numerical computations with good agreement. Both show the existence of a secondary flow generated by hydrodynamical instabilities due to streamline curvature. The main vortex flow appears then to be restricted by this secondary flow.

  3. Indications of hematopoietic stem cell transplantations and therapeutic strategies of accidental irradiations; Indications des greffes de cellules souches hematopoietiques et strategies therapeutiques des irradiations accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Produced by a group of experts, this document first discusses the issue of accidental irradiations in terms of medical management. They notably outline the peculiar characteristics of these irradiations with respect to therapeutic irradiations. They agreed on general principles regarding casualty sorting criteria and process, and their medical treatment (systematic hematopoiesis stimulation, allogeneic transplantation of hematopoietic stem cells). They discuss some practical aspects of these issues: casualty sorting within a therapeutic perspective (actions to be performed within 48 hours), therapeutic strategies (support therapy, use of cytokines, and therapy by hematopoietic stem cell transplant). They state a set of recommendations regarding the taking into care and diagnosis, therapeutic strategies, research perspectives, and teaching

  4. Etudes spectroscopiques du dopage dans les matériaux II-VI pour les détecteurs infrarouge et les cellules photovoltaïques

    OpenAIRE

    Frédérique, Gemain

    2012-01-01

    This thesis work presents optical and electrical characteristics of dopants in HgCdTe, CdZnTe and CdS layers. These 3 materials II-VI have mutual interest to be used in detection devices, for infrared light detection with HgCdTe and CdZnTe or for visible light detection in the case of CdS. Optical characterization of these II-VI layers was carried out with photoluminescence and was correlated with electrical measurements realized by temperature dependant Hall effect. First, a study of intrins...

  5. In vitro preparation of radionuclides labeled blood cells: Status and requirements; Preparation in vitro des cellules du sang marquees par des radionucleides: statut et recommandations

    Energy Technology Data Exchange (ETDEWEB)

    Couret, I. [Service de medecine nucleaire et radiopharmacie, hopital Lapeyronie, CHU de Montpellier, 34 - Montpellier (France); Desruet, M.D. [Service de medecine nucleaire et radiopharmacie, CHU de Grenoble, 38 - Grenoble (France); Bolot, C. [Service de pharmacie, hospices civils de Lyon, groupement hospitalier Est, 69 - Bron (France); Chassel, M.L. [Service de pharmacie et radiopharmacie, centre hospitalier de Chambery, 73 - Chambery (France); Pellegrin, M. [Inserm U896, CRLC Val-d' Aurelle-Paul-Lamarque, IRCM, universite Montpellier 1, 34 - Montpellier (France)

    2010-11-15

    Labelled blood cells permit nuclear medicine imaging using their physiological behaviours. The radiolabeling must be performed in vitro because of the lack of specific markers and requires several highly technical stages of preparation. Labelled blood cells have not the medication drug status, so that the nuclear physician conducting the nuclear test is fully liable. In most cases, the physician delegates the technical responsibility to radio-pharmacists. Although the status of radiolabelled autologous cells is not legally defined and in the absence of a specific repository, it is essential that their preparation is subject to the requirements of the rules of French Good Manufacturing Practice published by Agence francaise de securite sanitaire des produits de sante (Afssaps). It would be desirable to harmonize the practices of radiolabeling cellular blood components by editing a repository. (authors)

  6. Studio ultrastrutturale e morfometrico degli effetti in vitro di farmaci secretagoghi e relativi inibitori sulle cellule sierose delle ghiandole sottomandibolare e parotide umane

    OpenAIRE

    Perra, Anna

    2007-01-01

    La ricerca consiste nello studio, mediante la microscopia elettronica, dei processi di secrezione delle ghiandole salivari umane normali in condizioni di stimolazione in vitro con diverse sostanze in grado di interagire coi recettori cellulari. Seguendo tale intento, abbiamo condotto questa ricerca prendendo in considerazione specificatamente gli adenomeri sierosi delle ghiandole salivari parotide e sottomandibolare umane. Abbiamo pertanto proseguito le nostre ricerche sulla secrezione saliva...

  7. Mesenchymal stem cells, a hope for the treatment of radiotherapy complications; Les cellules souches mesenchymateuses, un espoir pour le traitement des complications des radiotherapies

    Energy Technology Data Exchange (ETDEWEB)

    Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire, Dir. de la Radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France); Semont, A.; Benderitter, M. [Institut de Radioprotection et de Surete Nucleaire. Laboratoire de Radiopathologie et Therapies Experimentales, 92 - Fontenay-aux-Roses (France)

    2010-10-15

    This article reports experimental researches performed by IRSN researchers in the field of cell therapy, notably for the treatment of severe accidental radiological burns. It shows than mesenchymal stem cells have been very efficient for the treatment of radio-induced of muscular cutaneous lesions, notably by reducing the pain where conventional analgesic treatments fail. A positive effect has been also obtained by using these stem cells for the treatment of severe intestinal lesions on mice locally irradiated with high doses. The tumorigenic risk associated with the use of these mesenchymal stem cells is also discussed

  8. Cellules solaires avec un absorbeur ll-Vl nanostructuré Matériaux et Propriétés

    OpenAIRE

    Salazar, Raul

    2012-01-01

    The development of semiconducting materials for the extremely thin absorber (eta) solar cell using cheap and scalable methods was the main objective of this work. The eta-solar cell is composed of all inorganic materials consisting of an extremely thin layer of absorbing material sandwiched between nanostructured transparent electron and hole conductors (Eg ≥ 3.3 eV). Compact and defect free ZnO thin film and nanowires (NWs) were prepared galvanostatically. The ZnO nanowire dimensions were co...

  9. Apport de la pression sur les performances d'une cellule d'électrolyse de la vapeur d'eau à haute température

    OpenAIRE

    Cacciuttolo, Quentin

    2014-01-01

    In order to improve the industrial attractiveness of high temperature steam electrolysis (HTSE), the increase in the operating pressure is one of the most promising solutions. In this context, this study is dedicated to the analysis of the pressure influence on the electrochemical reactions occurring in HTSE. A Model and experimental results dealing with the effect of pressure increase have been carried out. Concerning the cathodic side model, the limiting current density due to the lack of s...

  10. Vascular injuries in intestinal obstruction. The role of computed tomography; Complicazioni vascolari nelle occlusioni intestinali: ruolo della tomografia computerizzata

    Energy Technology Data Exchange (ETDEWEB)

    Vinci, R.; Angelelli, G.; Stabile Ianora, A.A.; Gaballo, A.; Rotondo, A. [Bari Univ., Bari (Italy). Dipt. di Medicina Interna e Medicina Pubblica, Serv. di Diagnostica per Immagini

    1999-09-01

    The paper investigates computerized tomography capabilities in showing vascular complications secondary to intestinal obstruction and for assessing the site and cause of obstruction. [Italian] Scopo del lavoro e' lo studio dell'uso della tomografia computerizzata nel riconoscimento di complicanze vascolari secondarie ad occlusione intestinale e della presenza, della natura e della sede dell'ostacolo alla canalizzazione intestinale.

  11. Infections in Combat Casualties During Operations Iraqi and Enduring Freedom

    Science.gov (United States)

    2009-04-01

    2 996.66 Infection joint prosthesis 2 996.67 Infection orthopaedic device 12 Central nervous system 320.89 Meningitis other bacteria 1 320.9...Cellulitis arm 37 682.4 Cellulitis hand 16 682.5 Cellulitis/abscess buttock 1 682.6 Cellulitis leg 77 682.7 Cellulitis foot 30 682.9 Cellulitis/abscess...Abrasion hip/leg infected 3 916.3 Blister hip/leg infected 2 917.3 Blister foot and toes-infected 2 958.3 Post-trauma wound infection 35 997.62 Infection

  12. Nouveaux substrats de silicium cristallin destinés aux cellules photovoltaïque à haut rendement : cas du silicium mono-like et du dopage aux donneurs thermiques liés à l’oxygène pour les cellules à hétérojonction de silicium

    OpenAIRE

    Jay, Frédéric

    2016-01-01

    This study aims to understand the electrical properties impact of the crystalline Silicon on the HeteroJunction (SHJ) solar cells performances and define the required material specifications in terms of minority carrier lifetime and bulk resistivity.In the first part of this work, the potential of the mono-like silicon was evaluated for SHJ solar cells production The high productivity of the crystallization method allows to significantly reduce the material cost. 20% efficiencies comparable t...

  13. Inflammation of the Orbit

    Science.gov (United States)

    ... Boomers Additional Content Medical News Inflammation of the Orbit (Inflammatory Orbital Pseudotumor) By James Garrity, MD, Mayo ... Socket Disorders Cavernous Sinus Thrombosis Inflammation of the Orbit Orbital Cellulitis Preseptal Cellulitis Tumors of the Orbit ...

  14. Imaging of Orbital Infections

    OpenAIRE

    Seyed Hassan Mostafavi

    2010-01-01

    Preseptal and orbital cellulitis occur more commonly in children than adults. The history and physical examination are crucial in distinguishing between preseptal and orbital cellulitis. The orbital septum delineates the anterior eyelid soft tissues from the orbital soft tissue. Infections anterior to the orbital septum are classified as preseptal cellulitis and those posterior to the orbital septum are termed orbital cellulitis. "nRecognition of orbital involvement is important not only...

  15. Impetigo

    Science.gov (United States)

    ... Aid: Poison Ivy/Oak/Sumac First Aid: Skin Infections Cellulitis Eczema Skin, Hair, and Nails Abscess MRSA Staph Infections What Are Germs? Cellulitis Abscess Impetigo Ringworm Cellulitis Hand Washing Impetigo Abscess Staph Infections MRSA Contact Us Print Resources Send to a ...

  16. Intestinal permeability and systemic endotoxemia in patients with acute pancreatitis.

    Science.gov (United States)

    Schietroma, Mario; Pessia, Beatrice; Carlei, Francesco; Mariani, Paola; Sista, Federico; Amicucci, Gianfranco

    2016-01-01

    La contaminazione batterica che si verifica nella necrosi pancreatica in corso di pancreatite acuta si pensa sia dovuto alla traslocazione batterica intestinale. Lo scopo di questo studio, a carattere clinico, è stato quello di valutare la permeabilità della mucosa intestinale e l’endotossemia in pazienti con pancreatite acuta. Sono stati studiati 63 pazienti con pancreatite acuta. In 42 pazienti la pancreatite era di grado moderato e in 21 di grado severo. La permeabilità intestinale fu valutata al giorno 0,1,3,7,9, e 11per mezzo del test di assorbimento al lattulosio/mannitolo. Per il dosaggio della endotossemia sono stati eseguiti prelievi di sangue venoso a 0,30,60,90,120, e 180 minuti, a 12,24 ore, e nei giorni 3,7,9, e 11. I pazienti con pancreatite acuta di grado severo hanno riportato un danno al livello della barriera intestinale di maggiore entità rispetto ai pazienti con pancreatite acuta di grado moderato essendo in rapporto L:M di 0.36 ± 0.15 e di 0.051± 0.013 rispettivamente (p sistemica dell’ endotossemia fu piu elevata nei pazienti con pancreatite acuta severa in confronto con pancreatite acuta moderata (p sistemica della endotossemia e la permeabilità intestinale misurate al giorno 7 nei pazienti con pancreatite moderata. (rs = 0.721; p = 0.001)e severa (rs = 0.956; p= 0.001). In conclusione possiamo affermare che la permeabilità intestinale è aumentata in pazienti con pancreatite acuta. I pazienti con pancreatite acuta severa vanno incontro ad un maggiore danno a livello della barriera intestinale. Inoltre la pancreatite (in particolar modo quella severa) è responsabile dell’ aumento della endotossemia. Questi risultati confermano l’ipotesi che ipoperfusione splancnica, che si verifica durante la pancreatite, può danneggiare la funzione della barriera mucosa intestinale, contribuire alla risposta infiammatoria sistemica e quindi all’insufficienza multi-organo.

  17. Frequency of intestinal parasites and evaluation of methods for their diagnosis in a marginal community of Medellin, Colombia = Frecuencia de parásitos intestinales y evaluación de métodos para su diagnóstico en una comunidad marginal de Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Jaiberth Antonio Cardona Arias

    2013-07-01

    Full Text Available Background: Intestinal parasitism is still a public health problem. It has not been thoroughly studied in Medellin, Colombia. Objective: To determine the prevalence of intestinal parasites in residents of a marginal community in Medellin and to evaluate the validity, efficiency and reliability of direct examination in its diagnosis. Methods: Cross-sectional study and evaluation of diagnostic tests. Data were collected from a primary information source. Proportions with their confidence intervals were calculated; non-parametric statistical tests and analysis of sensitivity, specificity, predictive values, negative likelihood ratio and kappa were done. Results: Prevalence of parasites, according to the results of the concentration test, was 74.4%. Evaluation was done for intestinal parasites in general and for the following categories: protozoa, helminthes, commensals and pathogens. Sensitivity war over 68%, specificity and positive predictive value were 100%, negative predictive value was over 74%, negative likelihood ratio was less than 0.32, kappa was greater than 0.77 and efficiency was over 90%. Conclusion: Prevalence of intestinal parasitism is as high as it was three decades ago; its solution needs prompt and effective intervention of health authorities. The tests available for its study, including direct examination of stools, are of high diagnostic value.

  18. Implicación del estrés oxidativo, alimentación, estilo de vida y variantes polimórficas del gen de apolipoproteína D en pacientes con pólipos intestinales y con adenocarcinoma esporádico de colon

    OpenAIRE

    Crespo Sanjuán, Jesús

    2012-01-01

    El estrés oxidativo (EO) constituye un mecanismo fundamental en la génesis de cáncer colorectal (CRC) dando lugar a las mutaciones que convierten las células en cancerosas. Comprobamos cómo existe un incremento del EO en sangre y en tejido de pacientes con pólipos y con CRC conforme avanza la enfermedad. Se trata del primer estudio que analiza en plasma de estos pacientes los valores de Mieloperoxidasa, encontrándose incrementados a medida que avanza el estadío. Los pacientes que consu...

  19. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  20. Introduction to the reliability study of IGBT switching cells under strong constraints; Introduction a l'etude de la fiabilite des cellules de commutation a IGBT sous fortes contraintes

    Energy Technology Data Exchange (ETDEWEB)

    Vallon, J.

    2003-12-15

    The reliability approach in power electronics is a complex problem including the coupling of current / voltage surges, physical and technological imperfections, from the die to the power circuit. First of all, we define a methodology based on the monitoring of a great number of components, during a long time campaign. Components are 600 V-50 A-20 kHz IGBT-diodes modules working in PWM inverter cells owing to an original opposition method. An exhaustive study of cell-switching failure modes allowed us to design a suitable and efficient protection. Afterwards, a complete reliability test bench was carried out with electrical and thermal monitoring. A preliminary screening protocol was also applied. The first results are presented in this thesis. (author)

  1. Aerodynamic Engine/Airframe Integration for High Performance Aircraft and Missiles (L’Integration Aerodynamique des Moteurs et des Cellules dans les Avions et les Missiles a Hautes Performances)

    Science.gov (United States)

    1992-09-01

    contact entre ]a maquetle et les patois , tout en emptchant urt rdpanitions de pression mesurdes (Fig.8). La nacelle seule provoque unec 6eoulement...8217occupation de la maquente dans ]a seine, des fotrnes intettne, ’decan maximal ye situars a 40% de 1’envergute du tron~on d’aile. En de patois haute

  2. Réalisation de cellules solaires nanostructurées à base de nanofils de ZnO. Matériaux et propriétés

    OpenAIRE

    Sanchez, Sylvia

    2012-01-01

    Nanostructured solar cells have been proposed as a solution for photovoltaic cost reduction and to rival the cost of grid-powered electricity. Regarding this challenge, two kinds of solar cells have been studied within the PhD thesis: the Extremely Thin Absorber Solar cells (eta) and the polymer hybrid solar cell. First, we are reporting on the electrochemical deposition of ZnO 2D layers and nanowires on glass substrates covered with TCO (Transparent Conducting Oxide). It is shown that the ba...

  3. Mass-charge-heat coupled transfers in a single cell of a proton exchange membrane fuel cell; Transferts couples masse-charge-chaleur dans une cellule de pile a combustible a membrane polymere

    Energy Technology Data Exchange (ETDEWEB)

    Ramousse, J.

    2005-11-15

    Understanding and modelling of coupled mass, charges and heat transfers phenomena are fundamental to analyze the electrical behaviour of the system. The aim of the present model is to describe electrical performances of a PEFMC according to the fluidic and thermal operating conditions. The water content of the membrane and the water distribution in the single cell are estimated according to the coupled simulations of mass transport in the thickness of the single cell and in the feeding channels of the bipolar plates. A microscopic model of a Gas Diffusion Electrode is built up to describe charges transfer phenomena occurring at the electrodes. Completed by a study of heat transfer in the Membrane Electrode Assembly, conditions and preferential sites of water vapor condensation can be highlighted. A set of measurements of the effective thermal conductivity of carbon felts used in fuel cells as porous backing layers have also been performed. Although the value of this parameter is essential for the study of heat transfer, it is still under investigation because of the strong thermal anisotropy of the medium. (author)

  4. Study and fabrication of solid oxide fuel cells through tape casting and co-sintering; Etude et realisation par coulage en bande et co-frittage de cellules de pile a combustible a oxydes solides

    Energy Technology Data Exchange (ETDEWEB)

    Grosjean, A

    2004-11-15

    This work is dedicated to the devising of a low-cost fabrication process of solid oxide fuel cells (SOFC). Technical requirements impose the shaping method: stripe casting as well as the materials used: Yttria-stabilized zirconia (YSZ), nickel and lanthanum manganite doped with strontium (LSM). In order to comply with environmental requirements the developed process uses an aqueous barbotine solvent. We get electrodes and the electrolyte separately, the use of an absorbent drying process has enabled us to join 3 layers to form an elementary cell with great interfacial homogeneity. The resistance of the cell to sintering has been improved through the symmetrization of the deformations of the cell. In order to interpret the low electrical properties of the cell and its quick damaging, transmission microscopy studies have been performed. These studies have shown 2 facts. First, 2 isolating phases appear at the cathode (at the LSM/YSZ interface) because of a too high sintering temperature and secondly, a quick clustering of nickel grains appears during cell operation that leads to a local loss of the nickel grid percolation. This problem has been solved by increasing the size of nickel oxide grains from 0.5 {mu}m to 3 {mu}m) to stabilize the microstructure. The issue of the reactivity at the LSM/YSZ interfaces was tackled in 2 different ways, we have tried to lower the sintering temperature by using a zirconia nano-powder first and then by replacing zirconia in the electrolyte by gadolinium-doped ceria. The use of zirconia nano-powder has failed to decrease sintering temperature while preserving the electrolyte density and the use of ceria has triggered instabilities that have not yet been solved. Despite all these drawbacks, this process allows the fabrication of an excellent anode/electrolyte interface. (A.C.)

  5. Synthesis and shaping of new cathode materials for ITSOFC fuel cell: fabrication and test cells; Synthese et mise en forme de nouveaux materiaux de cathode pour piles ITSOFC: realisation et tests de cellules

    Energy Technology Data Exchange (ETDEWEB)

    Lalanne, C.

    2005-10-15

    The development of the Solid Oxide Fuel Cells is dependent on the reduction of the cathodic over-potential measured at 600-700 Celsius degrees. In this way, in the last few years, we have made a selection from new cathode materials in the Institute; the oxygen over-stoichiometric oxides formulated A{sub 2}MO{sub 4+{delta}} (K{sub 2}NiF{sub 4}-type structure), show enhanced electrocatalytic and oxygen conduction properties. A detailed study has been performed on the compositions Nd{sub 2-x}NiO{sub 4+{delta}} (x = 0 and 0.05): the oxygen reduction is characterised by impedance spectroscopy and voltametry measurements (symmetrical configuration cell under air). Electrochemical analysis carried out under different oxygen partial pressures and various cathodic over-potentials have led us to identify the various contributions of the mechanism of the dioxygen reduction. Using powders with controlled morphology (coming from different synthesis ways) has resulted in a reduction of the electrode polarisation phenomena, which is the limiting step of the process still remaining in the interface cathode / electrolyte ionic transfer. In addition, due to these promising results (low area specific resistances and minimized cathodic over-potentials), the first tests in a complete fuel cell device have been performed. After an optimisation of the shaping parameters, i.e. selection of the suitable coating process and of the sintering thermal cycle, promising current densities of 1,3 A/cm{sup 2}, for 0,7 V have been measured at 800 Celsius degrees, the operating temperature. (author)

  6. Study of the cetuximab-ionizing radiation association on a model of in vitro endothelial cells; Etude de l'association cetuximab-radiations ionisantes sur un modele de cellules endotheliales in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Vautravers-Dewas, C.; Rebucci, M.; Lansiaux, A. [Centre Oscar-Lambret, Inserm U837, Lab. de Pharmacologie Antitumorale, 59 - Lille (France); Peixoto, P. [Inserm U837, 59 - Lille (France); Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2009-10-15

    These data support the existence of functional signalling tracks downstream epidermal growth factor receptor (E.G.F.R.) in endothelial cells. But our in vitro model, in two dimensional calculations, did not allow to show a radiosensitivity by cetuximab. The study of functional consequences of the association cetuximab-irradiation treatment will be relevant in an in vitro three dimensional model and on xenografts. (N.C.)

  7. Extension work-up for non-small-cell lung cancer; Thorax - cancer broncho-pulmonaire. Bilan d'extension des tumeurs malignes primitives broncho-pulmonaires non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Ait-Ameur, A.; El Fikri, A.; Teriitehau, C.; Minvielle, F.; Le Bivic, T.; Jeanbourquin, D. [Hopital d' Instruction des Armees Percy, Service d' Imagerie, 92 - Clamart (France)

    2003-02-01

    Surgery is the only potentially effective treatment of the non-small-cell lung neoplasm. Patient selection for surgery requires a rigorous protocol. In order to optimize the therapeutic strategy, the extension work-up must be designed to identify correctly locoregional spread and any contraindications as well as metastasis with assessment of mediastino-pulmonary lymph nodes. Radiology, particularly computed tomography, is highly contributive. Plain chest X-ray, ultrasound, magnetic resonance imaging (MRI) and possibly positron omission tomography (PET) may also be required. (authors)

  8. Modulation de la plasticité synaptique par les prostaglandines E2 à la synapse fibre moussue/cellule pyramidale CA3 en conditions physiologiques et dans un modèle murin de la maladie d'Alzheimer

    OpenAIRE

    2014-01-01

    Alzheimer’s disease (AD) is the most common form of dementia in elder people characterized by a loss of cognitive function linked to synaptic deficits. There is considerable evidence that neuroinflammation and AD are intimately linked. The key role of neuroinflammation in the course of the disease was figured out by epidemiological studies reporting a reduced prevalence to develop AD for patients chronically treated with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Prostaglandins are lipid...

  9. 上颌窦置管引流治疗幼儿鼻及鼻窦炎合并眶蜂窝织炎%Maxillary sinus drainage in the treatment of children's rhinosinusitis with orbital cellulitis

    Institute of Scientific and Technical Information of China (English)

    朱晓远; 娄卫华; 朱洪海; 台勇

    2013-01-01

    目的 探讨上颌寞置管引流治疗幼儿鼻及鼻寞炎(rhinosinusitis,RS)合并眶蜂窝织炎的方法和疗效.方法 21例幼儿RS合并眶蜂窝织炎的患儿应用上颌窦置管引流,合并全身抗生素应用和支持疗法.结果 患儿局部和全身症状在置管后迅速改善,平均术后于6~9d康复出院,无并发症及后遗症.结论 上颌寞置管引流和冲洗、联合抗生寨应用,治疗幼儿RS合并眶蜂窝织炎,是一种安全有效的治疗方法.

  10. Radiosensitizing effect of conjugated linoleic acid in MCF-7 and MDA-MB-231 breast cancer cells; Effet radiosensibilisateur de l'acide linoleique conjugue chez les cellules cancereuses de sein MCF-7 et MDA-MB-231

    Energy Technology Data Exchange (ETDEWEB)

    Drouin, G.; Douillette, A. [Univ. de Sherbrooke, Dept. de medecine nucleaire de radiobiologie, Faculte de medecine, Sherbrooke, Quebec (Canada); Lacasse, P. [Centre de recherche et development sur le bovin laitier et le porc, Lennoxville, Quebec (Canada); Paquette, B. [Univ. de Sherbrooke, Dept. de medecine nucleaire de radiobiologie, Faculte de medecine, Sherbrooke, Quebec (Canada)]. E-mail: benoit.paquette@USherbrooke.ca

    2004-02-01

    Apoptotic pathways in breast cancer cells are frequently altered, reducing the efficiency of radiotherapy. Conjugated linoleic acid (CLA), known to trigger apoptosis, was tested as radiosensitizer in breast cancer cells MCF-7 and MDA-MB-231. The CLA-mix, made up of the isomers CLA-9cis 11trans and CLA-10trans 12cis, was compared to three purified isomers, i.e., the CLA-9cis 11cis, CLA-9cis 11trans, and CLA-10trans 12cis. Using the apoptotic marker YO-PRO-1, the CLA-9cis 11cis at 50 {mu}mol/L turned out to be the best apoptotic inducer leading to a 10-fold increase in MCF-7 cells and a 2,5-fold increase in MDA-MB-231 cells, comparatively to the CLA-mix. Contrary to previous studies on colorectal and prostate cancer cells, CLA-10trans 12cis does not lead to an apoptotic response on breast cancer cell lines MCF-7 and MDA-MB-231. Our results also suggest that the main components of the CLA-mix (CLA-9cis 11trans and CLA-10trans 12cis) are not involved in the induction of apoptosis in the breast cancer cells studied. A dose of 5 Gy did not induce apoptosis in MCF-7 and MDA-MB-231 cells. The addition of CLA-9cis 11cis or CLA-mix has allowed us to observe a radiation-induced apoptosis, with the CLA-9cis 11cis being about 8-fold better than the CLA-mix. CLA-9cis 11cis turned out to be the best radiosensitizer, although the isomers CLA-9cis 11trans and CLA-10trans 12cis have also reduced the cell survival following irradiation, but using a mechanism not related to apoptosis. In conclusion, the radiosensitizing property of CLA-9cis 11cis supports its potential as an agent to improve radiotherapy against breast carcinoma. (author)

  11. In-situ study of the dendritic growth in lithium/polymer electrolyte-salt/lithium cells; Etude in-situ de la croissance dendritique dans des cellules lithium/POE-sel/lithium

    Energy Technology Data Exchange (ETDEWEB)

    Brissot, C.; Rosso, M.; Chazalviel, J.N. [Ecole Polytechnique, 91 - Palaiseau (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches

    1996-12-31

    The in-situ observation of dendritic growth in lithium/polymer electrolyte-LiTFSI/lithium battery cells shows that dendrites grow up with about the same rate as anion migration. Memory effects have been evidenced in cycling experiments and limit the dendrites length. An overall movement of the electrolyte due to variations of electrolyte concentration in the vicinity of the electrodes has been observed too. (J.S.) 13 refs.

  12. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    OpenAIRE

    César Moreira Sampaio; Lívia Maria Bittencourt Nossa; Ana Paula Ramos; Renata Abreu Paim; Roberto Lorens Marback

    2001-01-01

    Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecçõe...

  13. Développement de procédés pour des cellules photovoltaïques kesterite en couches minces à haut rendement et bas coût

    OpenAIRE

    Vauche, Laura

    2015-01-01

    Facing growing energy demand and increasing concerns about climate change and finite energy sources, solar energy use should increase. The future of the different photovoltaic technologies obviously depends on their power conversion efficiency and cost (summarized by the ratio cost per watt), but also on the elements availability. Thin films of earth-abundant kesterite, Cu2ZnSnS4 (CZTS), Cu2ZnSnSe4 (CZTSe) or Cu2ZnSn(S,Se)4 (CZTSSe), which can be manufactured with low-cost processes, are prom...

  14. Light ions radiobiological effects on human tumoral cells: measurements modelling and application to hadron-therapy; Mesures et modelisation des effets radiobiologiques des ions legers sur des cellules tumorales humaines: application a l'hadrontherapie

    Energy Technology Data Exchange (ETDEWEB)

    Jalade, P

    2005-11-15

    In classical radiotherapy, the characteristics of photons interactions undergo limits for the treatment of radioresistant and not well located tumours. Pioneering treatments of patients at the Lawrence Laboratory at Berkeley has demonstrated two advantages of hadrons beams: the Relative Biologic Effect (the RBE) and the ballistic of the beams. Since 1994, the clinical centre at Chiba, has demonstrated successfully the applicability of the method. A physics group, managed by G. Kraft, at Darmstadt in Germany, has underlined the advantages of carbon beams. An European pool, called ENGIGHT (European Network for LIGHt ion Therapy) has been created in which the French ETOILE project appeared. The purpose of the thesis concerns measurements and models of 'in vitro' human cells survival. In the first part, the nowadays situation in particles interactions, tracks and cells structures and radiobiology is presented here. The second is devoted to the models based on the beam tracks and localization of the physical dose. Discussion of sensitivity to various parameters of the model has been realized with the help of numerical simulations. Finally the predictions of the improved model has been compared to experimental irradiations of human cells with argon and carbon beams of the GANIL machine. Conclusion of such study shows the performance and limits of a local model for predicting the radiobiological efficiency of light ions in hadron-therapy. (author)

  15. Characterisation in vivo of ways of induced deaths by p53, in the male germinal cells; Caracterisation in vivo des voies de mort induites par la p53, dans les cellules germinales males

    Energy Technology Data Exchange (ETDEWEB)

    Coureuil, M

    2006-10-15

    The male germinal cells constitute a heterogeneous cell population including pre-meiotic proliferating cells (spermatogonia) and meiotic cells and post meiotic cells in differentiation (spermatocytes and spermatids). We study the involvement in vivo of the p53 protein in the death of these cells with the help of two models, (1) a transgenic model of infertility, MTp53, in which the p53 is over expressed in the differentiated cells and induced their death, (2) the response of these cells to gamma irradiation, where only the spermatogonia die by apoptosis dependent of p53. We showed that the caspases (cysteine-aspartic proteases) are involved in the terminal differentiation of normal germinal cells. But in the MTp53 model, the p53 induces the death of differentiated cells via the activation of calpains and not of caspases. We studied the response of spermatogonia, to gamma irradiation by a transcriptomic approach, by DNA chips and semi-quantitative RT-PCR. we showed that the puma and dr5 genes are induced by the p53 after irradiation. more, the study of mice invalidated for trail ( the dr5 ligand) or for puma, allowed to demonstrate that the two effectors are essential to the activation of intrinsic and extrinsic ways of apoptosis. (N.C.)

  16. Electrochemical deposition of thin nano-structured layers of CuInS{sub 2} for photovoltaic cells; Depot electrochimique de couches minces nanostructurees de CuInS{sub 2} pour cellules photovoltaiques

    Energy Technology Data Exchange (ETDEWEB)

    Cayzac, R.; Boulc' h, F.; Knauth, P. [Madirel Universite de Provence - 13397 Marseille Cedex 20 (France)

    2006-07-01

    In this work, it has been shown that the electrochemical deposition seems to be a promising synthesis technique because the thickness of the layers and their morphology are well adapted to the photovoltaic application. The example of CuInS{sub 2} has been taken. (O.M.)

  17. In vitro effects of piracetam on the radiosensitivity of hypoxic cells (adaptation of MTT assay to hypoxic conditions); Effets in vitro du piracetam sur la radiosensibilite des cellules hypoxiques (adapatation du test au MTT aux conditions d`hypoxie)

    Energy Technology Data Exchange (ETDEWEB)

    Gheuens, E.E.O.; Bruijn, E.A. de; Van der Heyden, S.; Van Oosterom, A.T. [Universitaire Instelling Antwerpen, Antwerp (Belgium); Lagarde, P. [Universitaire Instelling Antwerpen, Antwerp (Belgium)]|[Institut Bergonie, 33 - Bordeaux (France); Pooter, C.M.J. de [Universitaire Instelling Antwerpen, Antwerp (Belgium)]|[Hopital de Middelheim, Anvers (Belgium); Chomy, F. [Institut Bergonie, 33 - Bordeaux (France)

    1995-12-31

    This paper describes the adaptation of the MTT assay to hypoxic conditions in order to test the in vitro effect of piracetam on hypoxic cells and particularly on the radiosensitivity of hypoxic cells since this drug has shown clinical effect on acute and chronic hypoxia. The V79 cell line was selected by reference to preliminary hypoxic experiments using clonogenic assay and euoxic experiments using clonogenic and MTT assays. Cell growth and survival in our hypoxic conditions were assessed using MTT assay with an enclosure and special 48-well plates both made of glass. Growth curves on glass plates after 1-hour exposure to nitrogen versus air were comparable, so there is no bias effect due to gas composition. Survival curves using MTT versus reference clonogenic assay were comparable after radiation exposure in eu- and hypoxic conditions, and confirm the validity of our original technique for creating hypoxia. The Oxygen Enhancement Ratio was of about 3 for 1-hour hypoxic exposure. Piracetam gave no cytotoxic effect up to 10 mM of piracetam. Growth curves after continuous drug exposure and 1-hour euoxic versus hypoxic exposure gave no cytotoxic effect up to 10 mM of piracetam. Survival curves after continuous drug exposure to 10 mM of piracetam gave no significant effect on the radiosensitivity of hypoxic V79 cells using MTT or clonogenic assay. (author). 32 refs., 6 figs.

  18. Synthesis, characterization and nano-structuration of poly-thiophene derivatives for organic photovoltaic solar cells; Synthese, caracterisation et nanostructuration de derives du polythiophene pour des applications en cellules photovoltaiques organiques

    Energy Technology Data Exchange (ETDEWEB)

    Berson, S

    2007-10-15

    This work is devoted to the synthesis of poly-thiophene derivatives with low bandgap and preserving high oxidation potential. Disubstituted thiophenes and 'Donor-Acceptor' bi-thiophenes were synthesized and then polymerized. The side chains of these polymers, donor or acceptor, were modified in order to tune the properties of material as well from the optical point of view as electrochemical. These polymers were also tested in blend with PCBM in bulk-heterojunction photovoltaic cells. Voc delivered by the devices showed a linear dependence according to the potential of oxidation of the polymers. Copolymers containing cyano-thiophene and alkyl- or alkoxy-thiophene showed values of 0.8 V. However, in spite of power conversion efficiency of 1 %, these performances remain lower than the one obtained with the P3HT. Optimizations in terms of morphology are certainly necessary. Indeed, the morphology of the active layer plays a key role in obtaining high power conversion efficiency. An original technique of nano-structuration of the polymer on a nano-metric scale was developed during this work, leading to the development of fibrillar P3HT. These nano-structures, presenting an important degree of order, are formed spontaneously in solution. Their rate compared to amorphous material is perfectly controllable and adjustable in solution and in solid state. Measurements of mobilities show a strong improvement of the transport of load within these fibrillar layers compared to a traditional film of P3HT obtained without annealing. Power conversion efficiencies of 3.6% on glass and 3.3 % on plastic were reached without annealing. (author)

  19. Influence of the impurity-defect and impurity-impurity interactions on the crystalline silicon solar cells conversion efficiency; Influence des interactions impurete-defaut et impurete-impurete sur le rendement de conversion des cellules photovoltaiques au silicium cristallin

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, S

    2007-05-15

    This study aims at understanding the influence of the impurity - defect interaction on the silicon solar cell performances. We studied first the case of single-crystalline silicon. We combined numerical simulations and experimental data providing new knowledge concerning metal impurities in silicon, to quantify the evolution of the conversion efficiency with the impurity concentration. Mainly due to the gettering effects, iron appears to be quite well tolerated. It is not the case for gold, diffusing too slowly. Hydrogenation effects were limited. We transposed then this study toward multi-crystalline silicon. Iron seems rather well tolerated, due to the gettering effects but also due to the efficiency of the hydrogenation. When slow diffusers are present, multi crystalline silicon is sensitive to thermal degradation. n-type silicon could solve this problem, this material being less sensitive to metal impurities. (author)

  20. Etude de la durabilité de cellules d'électrolyse de la vapeur d'eau à haute température : influence des paramètres de fonctionnement

    OpenAIRE

    Mansuy, Aurore

    2012-01-01

    This work is dedicated to the study on the long term behavior of a solid oxide electrolysis cell (SOEC). More specifically, the target is to identify and understand the influence of main working parameters on the cell durability in order to find the best compromise between performances and durability. The initial part of this work is to characterize electrochemically the single cell selected for the study, that is to say a cathode supported cell of the type LSFC/YDC/8YSZ/Ni-YSZ at different g...

  1. Midterm Health and Personnel Outcomes of Recent Combat Amputees

    Science.gov (United States)

    2010-03-01

    998.5b-998.59 Osteomyelitis: 730.Ub-730.99 Cellulitis : 682.Ub-682.99 Chronic infection of amputation stump: 997.62 Infectioii/inflajiimatory due to...Syndrome Anemia Postoperative Infection Osteomyelitis Cellulitis Heterotopic Ossification Amputation Slump Complications Chronic Infection of Amputation...Infectiims Postoperative Infecüon Osteomyelilis Cellulitis Chronic Infection , Amputation Slump Infection /Inflammatory Due to Device Septicemia Stump

  2. 77 FR 13637 - Notice of Quarterly Report (October 1, 2011-December 31, 2011)

    Science.gov (United States)

    2012-03-07

    ... portfolio at risk >90 days of microfinance institutions at the national level. Operational self- sufficiency... of MFIs inspected by Cellule Supervision Microfinance. Access to Justice Project...........

  3. Sepsis

    Science.gov (United States)

    ... meningitis ) Liver or gallbladder Lungs ( bacterial pneumonia ) Skin ( cellulitis ) For people in the hospital, common sites of infection include intravenous lines, surgical wounds, surgical drains, and ...

  4. Infections

    Science.gov (United States)

    ... Infections Adenovirus Bronchiolitis Campylobacter Infections Cat Scratch Disease Cellulitis Chickenpox Chlamydia Cold Sores Common Cold Coxsackievirus Infections Croup Cytomegalovirus (CMV) Dengue Fever Diphtheria E. Coli ...

  5. Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care

    Science.gov (United States)

    2015-02-16

    Sepsis; Bacteraemia; Meningitis; Abscess; Pneumonia; Osteomyelitis; Cellulitis; Gastro-enteritis With Dehydration; Complicated Urinary Tract Infection; Viral Respiratory Infection Complicated With Hypoxia

  6. From pathogen defence to food allergy; The multiple facets of the mucosal immune system

    OpenAIRE

    Perrier, C.

    2007-01-01

    Résumé destiné à un large public Le système immunitaire associé aux muqueuses gastro-intestinales doit être capable de protéger notre organisme contre l'invasion de pathogènes. Parallèlement, il doit identifier en Cant que tels, des composés inoffensifs comme la nourriture ou les milliards de bactéries qui résident dans notre intestin. Le travail présenté ici aborde ces deux aspects essentiels au bon fonctionnement de notre muqueuse intestinale. Dans une première partie, la protéine nom...

  7. Elevada prevalencia de Cyclospora cayetanensis en indígenas del estado Bolívar, Venezuela High prevalence of Cyclospora cayetanensis among indigenous people in Bolivar State, Venezuela

    OpenAIRE

    Rodolfo Devera; Ytalia Blanco; Eva Cabello

    2005-01-01

    En la actualidad las coccidiosis intestinales causadas por Cryptosporidium parvum, Isospora belli y Cyclospora cayetanensis constituyen parasitosis de gran importancia médica, sin embargo, en el Estado Bolívar, Venezuela, se desconocen muchos aspectos epidemiológicos de estas infecciones. Entre julio de 2003 y abril de 2004 fue evaluada la población indígena San Antonio de Morichal con el objetivo de determinar la prevalencia de coccidiosis intestinales. Las muestras fecales obtenidas por eva...

  8. Elevada prevalencia de Cyclospora cayetanensis en indígenas del estado Bolívar, Venezuela

    OpenAIRE

    DEVERA Rodolfo; Blanco,Ytalia; Cabello,Eva

    2005-01-01

    En la actualidad las coccidiosis intestinales causadas por Cryptosporidium parvum, Isospora belli y Cyclospora cayetanensis constituyen parasitosis de gran importancia médica, sin embargo, en el Estado Bolívar, Venezuela, se desconocen muchos aspectos epidemiológicos de estas infecciones. Entre julio de 2003 y abril de 2004 fue evaluada la población indígena San Antonio de Morichal con el objetivo de determinar la prevalencia de coccidiosis intestinales. Las muestras fecales obtenidas por eva...

  9. Guias De Manejo De Las 10 Principales Causas De Morbilidad En Manizales

    OpenAIRE

    2007-01-01

    Las parasitosis intestinales son infeccionesproducidas por parásitos cuyo hábitat natural esel aparato digestivo del hombre. Todos losprotozoos intestinales patógenos tienen una distribuciónmundial, al igual que la mayoría de loshelmintos, aunque por las deficientes condicioneshigiénico-sanitarias se han asociado siemprea países tropicales o en vías de desarrollo.Para simplificar la clasificación, podemosdividirlos en dos grandes grupos: protozoos yhelmintos.Los protozoos que infectan al ser ...

  10. Imaging of Orbital Infections

    Directory of Open Access Journals (Sweden)

    Seyed Hassan Mostafavi

    2010-05-01

    Full Text Available Preseptal and orbital cellulitis occur more commonly in children than adults. The history and physical examination are crucial in distinguishing between preseptal and orbital cellulitis. The orbital septum delineates the anterior eyelid soft tissues from the orbital soft tissue. Infections anterior to the orbital septum are classified as preseptal cellulitis and those posterior to the orbital septum are termed orbital cellulitis. "nRecognition of orbital involvement is important not only because of the threatened vision loss associated with orbital cellulitis but also because of the potential for central nervous system complications including cavernous sinus thrombosis, meningitis, and death. "nOrbital imaging should be obtained in all patients suspected of having orbital cellulitis. CT is preferred to MR imaging, as the orbital tissues have high con-trast and the bone can be well visualized. Orbital CT scanning allows localization of the disease process to the preseptal area, the extraconal or intraconal fat, or the subperiosteal space. Axial CT views allow evaluation of the medial orbit and ethmoid sinuses, whereas coronal scans image the orbital roof and floor and the frontal and maxillary sinuses. If direct coronal imaging is not possible, reconstruction of thin axial cuts may help the assessment of the orbital roof and floor. Potential sources of orbital cellulitis such as sinusitis, dental infection, and facial cellulitis are often detectable on CT imaging. "nIn this presentation, the imaging considerations of the orbital infections; including imaging differentiation criteria of all types of orbital infections are reviewed.

  11. Dealing with Cuts (For Parents)

    Science.gov (United States)

    ... For Kids For Parents MORE ON THIS TOPIC Cellulitis First Aid: Cuts Staph Infections Bites and Scratches First Aid: Falls First Aid: ... Out Cuts, Scratches, and Abrasions What's a Scab? Cellulitis Cuts, Scratches, and Scrapes Staph Infections Dealing With Cuts and Wounds Contact Us Print ...

  12. Staphylococcal Infections

    Science.gov (United States)

    ... you should be familiar with include the following: Cellulitis is a bacterial skin infection that first affects the outer layers of the ... skin. Although other types of bacteria can cause cellulitis, Saureus ... may diagnose the infection by examining the area. The doctor may take ...

  13. Childhood Eye Diseases and Conditions

    Science.gov (United States)

    ... have a fever. More serious preseptal or orbital cellulitis infections can cause decreased vision, an inability to move the eye, and the appearance of the eye being pushed forward. What to do: Both forms of cellulitis are serious conditions that require urgent medical attention. ...

  14. 21 CFR 520.88g - Amoxicillin trihydrate and clavulanate potassium film-coated tablets.

    Science.gov (United States)

    2010-04-01

    ... and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep... infections, such as wounds, abscesses and cellulitis/dermatitis due to susceptible strains of beta-lactamase... susceptible strains of E. coli. (iii) Limitations. Skin and soft tissue infections: abscesses,...

  15. A rare case of abdominal cocoon.

    Science.gov (United States)

    Salamone, Giuseppe; Atzeni, Jenny; Agrusa, Antonino; Gulotta, Gaspare

    2013-10-05

    Il bozzolo (cocoon) addominale è una causa rara di ostruzione intestinale, generalmente diagnosticata casualmente alla laprotomia. Si manifesta per la formazione di una membrana che tipicamente incarcera le anse del tenue, provocandone l’occlusione meccanica. La diagnosi preoperatoria è difficile, e il momento etiologico non è ben compreso; ad ogni modo si tratta di una forma di irritazione ed infiammazione cronica. L’osservazione presentata riguarda un uomo del Bangladesh di 33 anni, ricoverato nel nostro dipartimento di emergenza per dolori addominali, nausea e vomito. La CT addominale mostrava il quadro di un’occlusione intestinale a livello del tenue. All’intervento si è presentato un incapsulamento del tenue da parte di una membrana biancastra e densa come un bozzolo. Il quadro istologico è stato quello di una peritonite con ritrovamento di Ascaris Lumbricoides nel tratto intestinale resecato. La diagnosi di cocoon addominale è difficile in fase preoperatoria, e dunque viene completata generalmente solo alla laparotomia, e la chirurgia resta il mezzo terapeutico fondamentale. La patogenesi del cocoon addominale rimane elusive, associate com’è a varie condizioni. La diagnosi iniziale nel nostro paziente è stata quella di occlusione intestinale da sindrome da incapsulamento (dai reperti TAC ed intraopeartori) di probabile natura primitiva, e solo la prova istologica ha dimostrato trattarsi di una peritonite granulomatosa associata alla presenza del parassita.

  16. L’esame microbiologico dei campioni di feci: procedura operativa diagnostica

    Directory of Open Access Journals (Sweden)

    Daniele Crotti

    2006-12-01

    Full Text Available Le infezioni intestinali diarroiche rimangono ancora oggi la causa principale di morbilità e mortalità diffusa nel mondo nonostante i progressi nella comprensione della loro epidemiologia, patogenesi e clinica. In tale Procedura Operativa Diagnostica si analizzano gli agenti patogeni batterici e virali, che, a livello intestinale, sono responsabili della diarrea infettiva. Per la ricerca

  17. Tri-Service Disability Evaluation Systems Database Analysis and Research. Annual Report 2011

    Science.gov (United States)

    2011-12-28

    43 6.1 367: Disorders of refraction and accommodation 8 6.7 401: Essential hypertension 41 5.8 P11: Operations on the cornea 8 6.7 300: Anxiety...aftercare 501 2.6 682: Other cellulitis and abscess 104 2.9 682: Other cellulitis and abscess 463 2.4 300: Anxiety, dissociative and somatoform...procedures 25 3.9 295: Schizophrenic disorders 165 3.6 682: Other cellulitis and abscess 24 3.7 998: Other complications of procedures 164 3.6

  18. Recidiverende halscellulitis hos nyfødt forårsaget af gruppe B-streptokokker

    DEFF Research Database (Denmark)

    Rasmussen, Annett Helleskov; Fenger-Grøn, Jesper

    2011-01-01

    Group B streptococci are an important cause of neonatal infection, and cellulitis is rarely found to be the clinical manifestation. In the present case a premature boy developed cellulitis and antibiotic sensitive group B streptococci were detected in blood culture. Despite pertinent treatment...... for 14 days he developed two relapses. At last antibiotic treatment was continued for a period of six weeks with no further relapse. To our knowledge no cases of relapse of neonatal group B streptococcal cellulitis in spite of recommended dose and duration of antibiotic treatment have been published...

  19. Contribution of the return of experience cell (C.R.E.X.) in the risk prevention and management in radiotherapy; Apport de la cellule de retour d'experience (CREX) dans la prevention et la gestion des risques en radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Coche Dequeant, B.; Dumortier, V.; Bouillon, J.; Cheval, V.; Forrest, M.; Giscard, S.; Lacornerie, T.; Lasue, A.; Malfait, B.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

    2007-11-15

    This study concerns the setting up of an analysis and follow up system of unwanted events in the radiotherapy department of the Oscar Lambret center at Lille. This work began on January 2007, the report will precise the functioning details and the first results of this cell. (N.C.)

  20. Estimation of the mediastinal involvement probability in non-small cell lung cancer: a statistical definition of the clinical target volume for 3-dimensional conformal radiotherapy?; Estimation de la propabilite d'envahissement tumoral mediastinal: une definition statistique du volume-cible anatomoclinique pour la radiotherapie conformationnelle des cancers bronchiques non a petites cellules?

    Energy Technology Data Exchange (ETDEWEB)

    Giraud, P.; Dubray, B.; Helfre, S.; Dauphinot, C.; Rosenwald, J.C.; Cosset, J.M. [Institut Curie, Dept. d' Oncologie-Radiotherapie, 75 - Paris (France); Rycke, Y. de [Institut Curie, Dept. de Biostatistiques, 75 - Paris (France); Minet, P. [Centre Hospitalier Universitaire, Service de Radiotherapie, Liege (Belgium); Danhier, S. [Hopital Europeen Georges-Pompidou, Service de Radiotherapie, 75 - Paris (France)

    2001-12-01

    Purpose. - Conformal irradiation of non-small cell lung carcinoma (NSCLC) is largely based on a precise definition of the nodal clinical target volume (CTVn). The reduction of the number of nodal stations to be irradiated would render tumor dose escalation more achievable. The aim of this work was to design an mathematical tool based on documented data, that would predict the risk of metastatic involvement for each nodal station. Methods and material. - From the large surgical series published in the literature we looked at the main pre-treatment parameters that modify the risk of nodal invasion. The probability of involvement for the 17 nodal stations described by the American Thoracic Society (ATS) was computed from all these publications and then weighted according to the French epidemiological data. Starting from the primitive location of the tumour as the main characteristic, we built a probabilistic tree for each nodal station representing the risk distribution as a function of each tumor feature. From the statistical point of view, we used the inversion of probability trees method described by Weinstein and Feinberg. Results. -Taking into account all the different parameters of I the pre-treatment staging relative to each level of the ATS map brings up to 20,000 different combinations. The first chosen parameters in the tree were, depending on the tumour location, the histological classification, the metastatic stage, the nodal stage weighted in function of the sensitivity and specificity of the diagnostic examination used (PET scan, CAT scan) and the tumoral stage. A software is proposed to compute a predicted probability of involvement of each nodal station for any given clinical presentation.Conclusion. -To better define the CTVn in NSCLC 3DRT, we propose a software that evaluates the mediastinal nodal involvement risk from easily accessible individual pretreatment parameters. (authors)

  1. Quantitative analysis of fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images on five patients irradiated for a non-small-cell bronchial cancer; Analyse quantitative d'images de TEP au fluorodesoxyglucose, au fluoromisonidazole et a la fluorothymidine chez cinq patients irradies pour un cancer bronchique non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Thureau, S.; Dubray, B. [Departement de radiotherapie et physique medicale, centre Henri-Becquerel, Rouen (France); Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Modzelewski, R.; Lelandais, B.; Edet Sanson, A.; Gardin, I.; Vera, P. [Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Departement de medecine nucleaire, centre Henri-Becquerel, Rouen (France)

    2011-10-15

    As fluorodeoxyglucose-PET (positron emission tomography) is used for the planning of non-small-cell bronchial carcinoma radiotherapy in order to help to define the gross tumour volume (GTV), and as new tracers have been developed to define a biological target volume, the authors report the comparison of several thresholding methods by using fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images. They notice important differences between the delineated volumes. Short communication

  2. Radioinduced pulmonary fibrosis: prospective study of clinical, dosimetric and biological predictive factors after conformal irradiation of non at small cells bronchi carcinomas; Fibroses radiques pulmonaires: etude prospective des facteurs predictifs cliniques, dosimetriques et biologiques apres irradiation conformationnelle des carcinomes bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Claude, L.; Ginestet, C.; Martel-Lafay, I.; Carrie, C. [Centre Leon-Berard, 69 - Lyon (France); Etienne-Mastroiani, B. [Hopital Louis-Pradel, 69 - Lyon (France); Arpin, D. [Hopital de la Croix-Rousse, 69 - Lyon (France); Vincent, M. [Hopital Saint-Luc-Saint-Joseph, 69 - Lyon (France); Falchero, L. [Hopital de Villefranche, 69 - Villefranche s/Saone (France); Blay, J.Y. [Hopital Edouard-Herriot, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, 69 - Lyon (France)

    2007-11-15

    This broad prospective study confirms the contribution of dosimetry factors ( pulmonary average dose, V10 to V50) in the predictive part for the delayed radioinduced fibrosis. Contrary to the acute radioinduced pneumopathy, no significant relationship has been underlined between the variations of cytokines and the delayed radioinduced fibrosis risk. (N.C.)

  3. Use of HMPAO-{sup 99m}Tc in radio-labelling endothelial cells: application to the study of the behaviour of endothelialized vascular prostheses under shearing constraint; Utilisation de HMPAO-{sup 99m}Tc pour le radio-marquage de cellules endotheliales: application pour etudier le comportement de protheses vasculaires endothelialisees sous contraintes de cisaillement

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Ph.; Bareille, R.; Brouillaud, B.; Barthe, N.; Rouais, F.; Bordenave, L. [Laboratoire de Biophisique, CHU-Bordeaux, 33076 Bordeaux (France)

    1997-12-31

    Insemination of the low-caliber vascular prostheses at the level of their endo-luminal surfaces by a monolayer of endothelial cells (EC) prior to their implantation diminishes their thrombogen character and increases their long-term expectation of permeability in humans. The aptitude of EC of remaining adherent to their support when exposed to the constraints of circulatory flux must be studied in vitro and all the authors quantify these adherence by the measurement of the loss of gamma activity of the vascular prosthesis after radiolabelling of EC by {sup 111}In oxinate. In this work EC of human origin, adherent to the culture surfaces were radiolabelled by HMPAO-{sup 99m}Tc and optimal conditions of the labelling were determined: the effect of increasing concentrations of HMPAO and increasing activities of HMPAO-{sup 99m}Tc on the viability and metabolic activity of EC; the influence of the temperature and of the time of touching on the labelling yield. Subsequently, this conditions were applied to EC having cultivated a innovative vascular prosthesis. Surface micro-auto-radiographies were realized. The best compromise was obtained with 10 MBq/10{sup 6} EC (40 {mu}g of HMPAO/10{sup 6} EC) corresponding to a labelling yield of 13.7 {+-} 0.7 after 3 hours of contact at 37 deg. C. The micro-auto-radiographies allow visualization of the intracellular radioactivity distribution. The study of adherence of EC to the vascular prosthesis, under shearing constraints, by means of a radiotracer provides numerous advantages vs current utilisation of {sup 111}In oxinate

  4. Air breath control radiotherapy in severe insufficiency respiratory patients with N.S.C.L.: application for deformable registration method in thoracic radiotherapy; Radiotherapie avec blocage respiratoire pour les grands insuffisants respiratoires atteints d'un carcinome pulmonaire non a petites cellules (Protocole RESPI 2000): application a la modelisation des deformations d'organes par recalage deformable

    Energy Technology Data Exchange (ETDEWEB)

    Sarrut, D.; Pommier, P.; Carrie, C. [Centre Leon-Berard, Dept. de Radiotherapie, CREATIS, Unite CNRS 5515, Inserm 630, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, Dept. de Biostatistique, 69 - Lyon (France)

    2006-11-15

    Purpose. Using deformable registration methods from a phase two clinical study of air breath control during radiotherapy in patients suffering from severe respiratory insufficiency and non-small cell lung carcinoma. Patients and methods, Between April 2002 and November 2005, 22 patients with severe respiratory insufficiency were treated with curative intent by conformal therapy combined with active breathing control. Results. After a mean of follow-up of 22 months, the local control rate is 28% and the method is feasible despite the severe respiratory insufficiency. However the overall survival is still poor due to metastatic widespread. For the second part of the study, the clinical protocol was also used for two studies using deformable registration methods. In the first study, a deformable registration method has been developed in order to register several breath-hold 3D CT of the same patient acquired at several days of interval. It allowed quantifying the inter-fraction breath-hold reproducibility by analysing the resulting displacement field. For 6 patients, the breath-hold was effective, while for 2 patients, motion greater than 10 mm were detected. The second study aimed to simulate 4D images from 3D breath-hold images. Developing an ad-hoc methodology based on the interpolation of 3D dense deformation fields performed it. The approach has been validated with expert selected landmarks, with accuracy lower than 3 mm. Conclusion. ABC is feasible, even in case of severe insufficiency respiratory syndrome but metastatic widespread disease is still a major challenge even with an acceptable local control rate without serious side effects: regarding the deformable registration method. Such artificial 4D images could allow decreasing the dose need to acquire a full 4D image, to simulate irregular breathing pattern and to be used for 4D dosimetry planning. (author)

  5. DIANE, a simulation code for the interaction of neutrons with living tissues. Application to low doses of fast neutrons on human tumoral cells; DIANE, un code de simulation de l'interaction des neutrons avec la matiere vivante. Applications aux faibles doses de neutrons rapides sur des cellules tumorales humaines

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, M.L

    2003-07-15

    Our work deals with the irradiation of cells and living tissues by 14 MeV neutrons at very low doses (a few 10{sup -2} Gy). Such experiments require an accurate knowledge of the values of neutron dose rates and fluences at the level of cell cultures. We have performed measurements of fluence rates through an activation method applied to gold and copper foils. The fluence rate is deduced from the gamma rays emitted by the irradiated foils. Neutron doses and dose rates have been measured through varied methods: PIN diodes, ionization tissue equivalent chambers, and Geiger-Mueller counters. We have designed the DIANE code to simulate the impact of energetic neutrons on cells. This code can be used with isolated cells or macroscopic tissues, it takes into account the roles of the ionisation electrons produced by recoil nuclei entering the cell. This point is all the more important since recent works have highlighted the impact of very low energy electrons on DNA. (A.C.)

  6. In vitro modulation of radiation-induced FAS-related apoptosis in CD34{sup +} progenitor cells by combination cytokines; Reduction de l'apoptose radio-induite impliquant le recepteur FAS au niveau des cellules hematopoietiques CD34{sup +} par une combinaison de cytokines

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Soutif, A.; Herodin, F

    1998-07-01

    Combination cytokines such as SCF, Flt-3 ligand, IL-3 and thrombopoietin can modulate Fas mRNA expression by in vitro irradiated CD34{sup +} cells which results in a moderate decrease of apoptotic ratio and an improved rate of clonogenicity of the irradiated progenitors. (authors)

  7. In vitro cytotoxic effects of PM{sub 2.5} from the city of Abidjan (Ivory Coast) on human A549 lung cells; Effets cytotoxiques in vitro des PM{sub 2,} {sub 5} de la ville d'Abidjan (Cote-d'Ivoire) sur des cellules pulmonaires humaines

    Energy Technology Data Exchange (ETDEWEB)

    Kouassi, Kouakou-Serge [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire); Billet, Sylvain; Garcon, Guillaume; Verdin, Anthony; Courcot, Dominique; Shirali, Pirouz [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Diouf, Amadou [Laboratoire de Toxicologie, Faculte de Medecine Pharmacologie Odontologie, Universite Cheikh Anta Diop, Dakar (Senegal); Cazier, Fabrice [Universite Lille Nord de France, Lille (France); Centre Commun de Mesures, MREI 1, Universite du Littoral Cote d' Opale, Dunkerque (France); Djaman, Joseph [Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire)

    2012-01-15

    Epidemiological studies associate air pollution, especially particulate, increased morbidity and mortality from respiratory and cardiovascular origin . Africa, which has an urbanization rate among the highest in the world, is particularly exposed. The 'Initiative on the air quality in Sub-Saharan Africa' showed the importance of atmospheric concentrations of certain pollutants such as nitrogen oxides, sulfur dioxide and particulate matter (PM{sub 10}). Like the great capitals of Africa, Abidjan, economic capital and most industrialized city of Ivory Coast is facing an air pollution from industrial-urban and health consequences for its population of nearly 6 million inhabitants. To better understand the mechanisms of action resulting from pulmonary exposure to particulate atmospheric aerosols, we proposed: (i) to collect atmospheric particles (PM{sub 2.5}) using high volume cascade impaction in the District of Abidjan in three influences (rural, urban or industrial), (ii) to determine their main physicochemical, (iii) assess their cytotoxicity and their role in the induction of oxidative damage in a model of human lung cells (A549) in culture. The chemical composition of the atmospheric particles revealed their heterogeneity, and many inorganic (e.g. Al, Ca, Fe, Mn, Zn, Ni, Cr, Cu, Pb, Mg) and organic compounds (e.g. paraffins) were quantified at the three sites. Their effect concentrations (EC) to 10 and 50% on the A549 were as follows: influence rural: EC{sub 10} = 5.91 {mu}g/cm{sup 2} and EC{sub 50} 29.55 {mu}g/cm{sup 2}, urban influence: EC{sub 10} = 5 .45 {mu}g/cm{sup 2} and EC{sub 50} = 27.23 {mu}g/cm{sup 2}, and industrial influence: EC{sub 10} = 6.86 {mu}g/cm{sup 2} and EC{sub 50} = 34.29 {mu}g/cm{sup 2}. Exposure of A549 cells to Abidjan city's PM samples for 24, 48 or 72 hours to their EC{sub 10} or EC{sub 50} induced oxidative damage, as demonstrated by the formation of malon-dialdehyde, changes in enzyme activity of superoxide dismutase and alteration of glutathione status. (authors)

  8. Microsystème dédié à l’étude de la polarisation diélectrique de microparticules dans le cadre de formation master recherche : application au micropositionnement 3D de cellules par force de diélectrophorèse

    OpenAIRE

    Sieskind, Rémi; Trainito, Claudia; Français, Olivier; Le Pioufle, Bruno

    2015-01-01

    International audience; A l’ENS de Cachan, le département E.E.A. a mis en place une série de travaux pratiques portant sur l’utilisation d’un microsystème « électro-fluidique », réalisé en salle blanche, pour le micro-positionnement par champ électrique d’objets inertes ou biologiques de dimension micrométrique. Cet enseignement est développé dans des formations de niveau Master.Le principe physique, exploité au travers des séances pédagogiques, est la polarisation diélectrique de microobjets...

  9. Effect of ionizing radiation on hematopoietic stem cells and progenitor cells: Role of apoptosis and potential therapeutic significance of anti-apoptotic treatments; Effet des rayonnements ionisants sur les cellules souches et progeniteurs hematopoietiques : place de l'apoptose et interet therapeutique potentiel des traitements antiapoptotiques

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mourcin, F.; Grenier, N.; Mayol, J.F.; Leroux, V. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France); Sotto, J.J. [Inst. Albert Bonniot, La Tronche (France); Herodin, F. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    Bone marrow aplasia observed following ionizing radiation exposure (Total Body Irradiation; gamma dose range: 2-10 Gy) is a result, in particular, of the radiation-induced (RI) apoptosis in hematopoietic stem and progenitor cells (HSPC). We have previously shown in a baboon model of mobilized peripheral blood CD34{sup +} cell irradiation in vitro that RI apoptosis in HSPC was an early event, mostly occurring within the first 24 hours, which involves the CD95 Fas pathway. Apoptosis may be significantly reduced with a combination of 4 cytokines (4F): Stem Cell Factor (SCF), FLT-3 Ligand (FL), thrombopoietin (TPO), and interleukin-3 (IL-3), each at 50 ng{center_dot}mL{sup -1} (15% survival versus <3% untreated cells, 24 h post-irradiation at 2.5 Gy). In this study we show that addition of TNF-{alpha}(800 IU/ml) induces an increase in 4F efficacy in terms of cell survival 24 h after incubation (26% survival after 24 h irradiation exposure at 2.5 Gy) and amplification (k) of CD34{sup +} cells after 6 days in a serum free culture medium (SFM) (k{sub CD34{sup +}} = 4.3 and 6.3 respectively for 4F and successive 4F + TNF-{alpha}/4F treatments). In addition, the 4F combination allows culture on pre-established allogenic irradiated stromal cells in vitro at 4 Gy (k{sub CD34{sup +}} = 4.5). Overall this study suggests (i) the potential therapeutic interest for an early administration of anti-apoptotic cytokines with or without hematopoiesis inhibitors (emergency cytokine therapy) and (ii) the feasibility in the accidentally irradiated individual, of autologous cell therapy based on ex vivo expansion in order to perform autograft of residual HSPC collected after the accident. (author)

  10. Bulky PAH-DNA induced by exposure of a co-culture model of human alveolar macrophages and embryonic epithelial cells to atmospheric particulate pollution; Adduits encombrants a l'ADN dans des cocultures de cellules pulmonaires humaines exposees a une pollution atmospherique particulaire

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, Imane; Garcon, Guillaume; Billet, Sylvain; Shirali, Pirouz [Universite Lille Nord de France - Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Andre, Veronique; Le Goff, Jeremie; Sichel, Francois [GRECAN, Universite de Caen Basse-Normandie et centre Francois Baclesse, Caen (France); Roy Saint-Georges, Francoise; Mulliez, Philippe [Service de Pneumologie, Hopital Saint-Philibert, GHICL, Lille (France)

    2012-01-15

    Because of their deep penetration in human lungs, fine airborne particulate matter were described as mainly responsible for the deleterious effects of exposure to air pollution on health. Organic constituents are adsorbed on particles surface and, after inhalation, some (polycyclic aromatic hydrocarbons, PAHs) can be activated into reactive metabolites and can bind to DNA. The formation of bulky DNA adducts has been researched after exposure of mono-and co-cultures of alveolar macrophages (AM) and human embryonic human lung epithelial (L132), to fine air pollution particulate matter Air samples have been collected with cascade impactor and characterized: size distribution (92.15% < 2.5{mu}.m), specific surface area (1 m{sup 2}/g), inorganic (Fe, AI, Ca, Na, K, Mg, Pb, etc.) and organic compounds (PAHs, etc.). {sup 32}P post-labeling method was applied to detect bulky DNA adducts in AM and L132, in mono-and co-cultures, 72 h after their exposure to atmospheric particles at their Lethals and Effects concentrations or (LC or CE) to 50% (i.e. MA: EC{sub 50} = 74.63 {mu}g/mL and L132: LC-5-0 = 75.36 {mu}g/mL). Exposure to desorbed particles (MA: C1= 61.11 {mu}g/mL and L132 : C2 = 61.71 {mu}g/mL) and B[a]P (1 {mu}M) were included. Bulky PAH-DNA adducts were detected in AM in mono-culture after exposure to total particles (Pt), to B[a]P and desorbed particles (Pd). Whatever the exposure, no DNA adduct was detected in L132 in mono-culture. These results are coherent with the enzymatic activities of cytochrome P450 l Al in AM and L132. Exposure of co-culture to Pt, or Pd induced bulky adducts to DNA in AM but not in L132. Exposure to B[a]P alone has altered the DNA of AM and L132, in co-culture. Exposure to Pt is closer to the environmental conditions, but conferred an exposure to amounts of genotoxic agents compared to studies using organic extracts. The formation of bulky DNA adducts was nevertheless observed in AM exposed to Pt, in mono- or co-culture, indicating that they were competent in terms of metabolic activation of PAHs. The DNA damage in the L132 in co-culture following exposure to B[a]P have suggested that some PAH metabolites generated by the MA could be have a genotoxic action on L132. (authors)

  11. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  12. Usefulness of {sup 99m}Tc-depreotide scintigraphy for the diagnosis of bone metastases in non-small cell lung cancer stage 3-4; Apport de la scintigraphie au {sup 99m}Tc-depreotide pour le diagnostic de lesions osseuses secondaires dans le cancer bronchopulmonaire non a petites cellules stade 3-4

    Energy Technology Data Exchange (ETDEWEB)

    Costo, S.; Dunet, V.; Agostini, D.; Bouvard, G. [CHU Cote de Nacre, Service de Medecine Nucleaire et Isotopes, 14 - Caen (France); Halley, A. [Centre Havrais d' Imagerie Nucleaire, 76 - Montivilliers (France); Bergot, E.; Porret, E.; Zalcman, G. [CHU Cote de Nacre, Service de Pneumologie, 14 - Caen (France)

    2009-02-15

    Objective In non-small cell lung cancer (NSCLC), metastatic bone involvement is usually assessed using conventional {sup 99m}Tc-HMDP bone scintigraphy, which has a high sensitivity but a poor specificity. The purpose of this study was to assess the usefulness of the {sup 99m}Tc-D scintigraphy for the detection of malignant bone metastases in patients with NSCLC stage III or IV and to compare these results with {sup 99m}Tc-HMDP bone scan findings. Methods Nineteen patients (13 M and 6 F, mean age 59 years) with proven NSCLC, suspected to have stage III or IV were enrolled prospectively. All patients underwent whole body {sup 99m}Tc-HMDP and {sup 99m}Tc-D scintigraphy to detect bone metastases within a mean interval of 14 days. Each focal uptake of {sup 99m}Tc-D or {sup 99m}Tc-HMDP was considered benign or malignant, leading to positive or negative diagnosis for bone involvement. The final diagnosis of bone metastases was established by a lung specialist, on the basis of additional imaging modalities and of 12 months follow-up. Results Twelve bone lesions were identified by {sup 99m}Tc-D scintigraphy, 10 were classified as bone metastases and two were classified as inflammatory bone lesions. Four patients were metastatic. Fifty eight bone lesions were detected by {sup 99m}Tc-HMDP scintigraphy, 26 of whom were considered malignant, eight patients were thus considered metastatic. Thereby, the two nuclear medicine modalities were concordant for 13 patients, that is 68% of cases and were discordant for six patients, representing 32% of cases. Diagnostic sensitivity, specificity and accuracy of depreotide scintigraphy and {sup 99m}Tc-HMDP bone scintigraphy were 75% for both, 93.3 and 73.3%, and 89.5 and 73.3% respectively. Conclusion Our data suggest that depreotide scintigraphy with the same sensitivity, a better accuracy and specificity than those of {sup 99m}Tc-HMDP bone scan can detect metastatic bone lesions in patients with NSCLC suspected to have stage III or IV disease. (authors)

  13. Identification of human genes involved in cellular responses to ionizing radiation: molecular and cellular studies of gene encoding the p68 helicase in mammalian cells; Identification de genes humains impliques dans la reponse cellulaire aux radiations ionisantes: etudes moleculaire et cellulaire du gene codant l'helicase p68 dans les cellules de mammiferes

    Energy Technology Data Exchange (ETDEWEB)

    Menaa, F.

    2003-12-15

    Cells submitted to genotoxic factors -like IR- activate several and important mechanisms such as repair, cell cycle arrest or 'apoptosis' to maintain genetic integrity. So, the damaged cells will induce many and different genes. The human transcriptome analysis by 'SSH' method in a human breast carcinoma cell line MCF7 {gamma}-irradiated versus not irradiated, allowed to identify about one hundred genes. Among of these genes, we have focused our study on a radio-induced gene encoding the p68 helicase. In the conditions of irradiation used, our results show that the kinetic and the regulation of this gene expression differs between the nature of radiations used. Indeed, in {gamma}-irradiated mammalian cells, ATM, a protein kinase activated by DSB and IR, is required to induce quickly P68 gene via the important transcription factor p53 stabilized by IR. In the case of UVC-irradiated cells, the P68 gene induction is late and the intracellular signalling pathway that lead to this induction is independent from the p53 protein. Finally, we show that the p68 protein under-expression is responsible for an increased radiosensitivity of MCF7 cells. Consequently, we can postulate that the p68 protein is involved in cellular responses to radiations to reduce the increased radiosensitivity of cells exposed to {gamma}-rays. (author)

  14. Synthesis of nano-particles by soft chemistry: structural, morphological and dimensional control. Studies of the electrochemical properties (towards dyes solar cells); Synthese de nanoparticules par chimie douce: controle structural, morphologique et dimensionnel. Etudes des proprietes electrochimiques (vers les cellules solaires a colorants)

    Energy Technology Data Exchange (ETDEWEB)

    Cassaignon, S.; Koelsch, M.; Jolivet, J.P. [Paris-6 Univ. Pierre et Marie Curie, Chimie de la Matiere Condensee de Paris, CNRS UMR 7574, 75 - Paris (France)

    2006-07-01

    In this work are described the electrochemical behaviour of different TiO{sub 2} films (anatase, brookite and rutile) in aqueous solution and the influence of the parameters as the crystal structure and the morphology on the electrochemical answer. To complete this study, the capacity of the double layer has been measured by impedance spectroscopy. Voltage measurements of TiO{sub 2} sensitized by a dye will allow to discuss the reversibility of the system and the rearrangement mechanisms. At last, the influence of the nature of the TiO{sub 2} particles (anatase, rutile and brookite) on the photovoltage has been studied in order to estimate their interest for photovoltaic devices. (O.M.)

  15. The fibroblast growth factor-2 (F.G.F.-2) expression predicts the tumoral response and the local of non at small cells bronchi cancers after chemoradiotherapy; L'expression de FGF-2 predit la reponse tumorale et le controle local des cancers bronchiques non a petites cellules apres chimioradiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Massabeau, C.; Toulas, C.; Moyal, E. [Institut Claudius-Regaud, 31 - Toulouse (France); Rouquette, I.; Lauwers-Cances, V.; Mazieres, J. [Centre Hospitalier Universitaire, 31 - Toulouse (France)

    2007-11-15

    The tumoral expression of the fibroblast growth factor-2 is correlated with a bad response to chemotherapy and a strong rate of local recurrence. F.G.F.-2 would define a radioresistant phenotype of non at small cells bronchi carcinoma. (N.C.)

  16. Study of feasibility of the preoperative chemoradiotherapy for stage 2B/3 non at small cells bronchi cancer and histological response: about 107 cases treated at Avignon; Etude de faisabilite de la chimioradiotherapie preoperatoire pour cancer bronchique non a petites cellules de stades 2B/3 et reponse histologique: a propos de 107 cas traites a Avignon

    Energy Technology Data Exchange (ETDEWEB)

    Pourel, N.; Hilgers, W.; Mineur, L.; Reboul, F. [Institut Sainte-Catherine, 84 - Avignon (France); Santelmo, N. [Centre Hospitalier H.-Duffaut, 84 - Avignon (France); Molinari, N. [Laboratoire de biostatistique, faculte de Medecine, 34 - Montpellier (France)

    2006-11-15

    The preoperative chemoradiotherapy is an induction treatment that is feasible for stage 2B/3 non at small cells for patients whom Who performance index is 0-1. The surgery is to question if a pneumonectomy, particularly right one, is necessary. The histological response to chemoradiotherapy is a factor of forecasting of the global survival. (N.C.)

  17. Study of the action of a phosphonate additive on steel scale deposit and corrosion in the hydrodynamic conditions of a channel flow cell; Etude de l'action d'un additif phosphone sur l'entartrage et sur la corrosion de l'acier dans les conditions hydrodynamiques d'une cellule a canal

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, C.

    2000-10-17

    In cooling systems, an improved control of scale deposit and corrosion processes is a major challenge and an realistic evaluation tool for water treatments is of the utmost economic importance. In this study, a channel flow cell was used to allow in-situ electrochemical measurements in well defined electrolyte tube flowing conditions. An expression of the mass transfer towards the electrode was established where the diffusion-limited current is a function of Re{sup 1/3} in the laminar regime and was verified experimentally using the redox couples Fe[CN]{sub 6}{sup 4-}/ Fe[CN]{sub 6}{sup 3-} and O{sub 2}/OH{sup -}. This hydrodynamically controlled experimental device was developed to investigate scale deposit processes and to evaluate scale inhibitor efficiency using a electrochemical quartz crystal microbalance. Experiments were performed on three different waters, at various flow rates and temperatures. The efficiency of a well known phosphonate (HEDP) was tested at different concentrations and an optimum concentration could be established (0.7 mg dm{sup -3}). The effect of additive injection during the scale formation as well as the influence of flow rate on the inhibiting efficiency were evaluated. The anti-scale additive was shown to be more effective in the turbulent regime. HEDP has shown a strong effect on inhibiting crystal growth and that affected the morphology of CaCO{sub 3} crystals. The HEDP effect on protecting carbon steel against corrosion was also studied in mineral water containing Ca{sup 2+} ions. It was found that anti-corrosion effect of HEDP is enhanced by the presence of calcium in solution and that is due to the formation of an HEDP-Ca{sup 2+} complex, which adsorbs onto the metallic surface and protects it from dissolution. (author)

  18. Follow-up of patients treated by erlotinib (Tarceval) for a non at small cells lung cancer by PET-F.D.G.: preliminary results; Suivi de patients traites par erlotinib (Tarceval) pour cancer bronchique non a petites cellules par TEP-FDG: resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Vervueren, L.; Berthelot, C.; Rakotonirina, H.; Lacoeuille, F.; Cahouet Vannier, A.; Le Jeune, J.J.; Couturier, O. [Service de medecine nucleaire et biophysique, CHU d' Angers, (France)

    2009-05-15

    This study is in the frame of the evaluation of targeted therapies. Its principal objective is to provide information on the tumor metabolism evolution by PET-F.D.G. for patients treated for non at small cells bronchi carcinomas by erlotinib (Tarceval), an inhibitor of tyrosine kinase targeting the receptor to epidermal growth factor (E.G.F.). The secondary objectives are to evaluate at term, the interest of the PET-F.D.G. in the identification of responder patients and the early evaluation of the therapy response. (N.C.)

  19. 肺炎支原体感染对老年慢性阻塞性肺疾病急性发作及肺炎患者免疫功能的影响%Role of mycoplasma pneumoniae infection in exacerbated stage of COPD and on celluler immune system of community acquired pneumonia patients

    Institute of Scientific and Technical Information of China (English)

    邓朝胜; 陈美云; 林其昌; 吴可贵; 唐爱忠; 翁义锐

    2004-01-01

    目的探讨肺炎支原体感染(MP)对老年慢性阻塞性肺疾病(COPD)急性发作及社区获得性肺炎(肺炎)患者细胞免疫功能的影响. 方法 39例老年COPD急性发作、40例老年肺炎患者及30例老年健康对照者用ELISA法测定其血清MP特异性IgM、IgG抗体及干扰素-γ(IFN-γ)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)含量;通过聚合酶链式反应(PCR)法检测痰液中的MP. 结果 (1)COPD组MP PCR法及MP-IgM阳性率明显高于肺炎组及对照组(P<0.05);(2)COPD组IFN-γ含量明显低于肺炎组(P<0.01),而TNF-α含量则反之;(3)COPD、肺炎组MP-IgM阳性者IFN-γ含量明显低于组内MP-IgM阴性者(P<0.05). 结论 (1)老年人中COPD急性发作MP感染阳性率显著高于肺炎患者;(2)老年COPD急性发作患者IFN-γ水平明显低于老年肺炎患者,而TNF-α、IL-6水平则显著升高;(3)MP感染可能抑制了老年人COPD急性发作及肺炎患者IFN-γ的产生.

  20. Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC - treatment results after long-term follow-up and literature overview; Radiotherapie mediastinale apres chimiotherapie et irradiation prophylactique de l'encephale chez des patients atteints d'un carcinome bronchique a petites cellules - Resultats et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, M.K.A.; Bloch, E.; Overbeck, T.; Wolff, H.A.; Hille, A.; Hess, C.F.; Christiansen, H. [Department of Radiotherapy, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Koerber, W. [Department of Pneumology, Weende Hospital, Section Lenglern, Pappelweg 5, 37120 Bovenden-Lenglern (Germany); Vorwerk, H. [Department of Hematology and Oncology, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Muller, M.; Pradier, O. [Department de cancerologie, CHU Morvan, 5, avenue Foch, 29200 Brest cedex (France)

    2011-04-15

    Introduction. - Curative therapy for patients with small-cell lung cancer (SCLC) is based on multidrug chemotherapy combinations and radiotherapy. After a long time follow-up, the aim of the study was to evaluate the efficacy and toxicity of sequential chemo-radiotherapy and the effect of prophylactic cranial irradiation (PCI). Methods. - From 1995-2005, 96 patients with SCLC (64 limited-disease [LD], 32 extensive-disease [ED]; median age 61 years [range 39-79]) were treated at our department with varying chemotherapy regimens and sequential mediastinal radiotherapy (50 Gy + 10 Gy boost in case of residual disease after chemotherapy). Afterwards, 15 patients with LD, good general condition and at least partial response after local treatment received PCI (30 Gy). Results. - After a median follow-up of 78.6 months, 20 patients remained alive (20.8%, median survival time 18.2 months). The 2-/5-year overall survival rates were 33.8% and 12.6%, the 2-/5-year loco-regional control rates were 30.3% and 24.5%, respectively. Distant metastases occurred in 43 patients (24 cerebral). Cerebral metastasis occurred in 6.7% and 27.2% of the patients with PCI and without PCI respectively. Only tumor stage showed a statistically significant impact on overall survival and loco-regional control in multivariate analysis. Radiotherapy was well tolerated. Grade 3/4 toxicity occurred in seven patients. Prognosis of patients with SCLC remains poor. Administration of PCI in selected patients bears a decrease in the incidence of cerebral metastases. Alternative chemotherapy schemes as well as irradiation schemes and techniques should be the substance of future randomized trials. (authors)

  1. Mouth ulcers

    Science.gov (United States)

    ... include: Canker sores Gingivostomatitis Herpes simplex ( fever blister ) Leukoplakia Oral cancer Oral lichen planus Oral thrush A ... chap 22. Read More Canker sore Cellulitis Gingivostomatitis Leukoplakia Lichen planus Mouth sores Oral cancer Tooth abscess ...

  2. Management of orbital complications of sinusitis in pediatric patients.

    Science.gov (United States)

    Kinis, Vefa; Ozbay, Musa; Bakir, Salih; Yorgancilar, Ediz; Gun, Ramazan; Akdag, Mehmet; Sahin, Muhammed; Topcu, Ismail

    2013-09-01

    The most common reason of orbital infections is sinusitis. Orbital complications of sinusitis are mostly seen in children. Loss of vision and intracranial infections are among the complications of sinusitis. Prompt diagnosis and treatment is very important in the management of orbital complications. The orbital complication can be in the form of cellulitis or abscess. A retrospective review of 26 pediatric patients with orbital complications due to sinusitis was presented in this study. Of 26 patients, there were 13 cases of preseptal cellulitis, 2 cases of orbital cellulitis, and 11 cases of subperiosteal abscess. We grouped the preseptal and orbital cellulites in one category and the subperiosteal abscess in the other. All patients in the cellulitis group recovered by medical treatment. All the patients were treated by surgical drainage. Early diagnosis and appropriate treatment method are vital for the treatment of orbital complications secondary to sinusitis.

  3. Omfalitis med fatal udgang hos en nyfødt dreng

    DEFF Research Database (Denmark)

    Debes, Nanette M M Mol; Dahl, Marianne; Jonsbo, Finn

    2008-01-01

    Omphalitis is a serious condition with important morbidity and mortality, especially in developing countries. The most commonly involved micro-organisms are Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. We describe a Danish patient with cellulitis...

  4. [Omphalitis with fatal outcome in new-born baby boy

    DEFF Research Database (Denmark)

    Debes, N.M.; Dahl, M.; Jonsbo, F.

    2008-01-01

    Omphalitis is a serious condition with important morbidity and mortality, especially in developing countries. The most commonly involved micro-organisms are Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. We describe a Danish patient with cellulitis...

  5. The use of differential scintigraphy in the clinical diagnosis of osseous and soft tissue changes affecting the diabetic foot

    Energy Technology Data Exchange (ETDEWEB)

    Visser, H.J.; Jacobs, A.M.; Oloff, L.; Drago, J.J.

    Prompt recognition of cellulitis, osteomyelitis, diabetic osteolysis, Charcot neuroarthropathy, septic synovitis, and deep plantar abscesses in the diabetic foot is essential because the therapy is drastically different. Differential diagnosis has been greatly facilitated by recently developed scanning techniques.

  6. InterProScan Result: FS936446 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 33 ER lumen protein retaining receptor Biological Process: protein retention in ER lumen (GO:0006621)|Cellul...ar Component: integral to membrane (GO:0016021)|Molecular Function: ER retention sequence binding (GO:0046923) ...

  7. InterProScan Result: FS784123 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 33 ER lumen protein retaining receptor Biological Process: protein retention in ER lumen (GO:0006621)|Cellul...ar Component: integral to membrane (GO:0016021)|Molecular Function: ER retention sequence binding (GO:0046923) ...

  8. SHEWANELLA AND PHOTOBACTERIUM IN OYSTERS AND SEAWATER FROM THE DELAWARE BAY

    Science.gov (United States)

    Shewanella algae, S. putrefaciens, and Photobacterium damselae subsp. damselae are indigenous marine bacteria and human pathogens causing cellulitis, necrotizing fasciitis, abscesses, septicemia, and death. Infections are rare and are most often associated with the immunocompromized host. A study ...

  9. Necrotizing soft tissue infection

    Science.gov (United States)

    Necrotizing fasciitis; Fasciitis - necrotizing; Flesh-eating bacteria; Soft tissue gangrene; Gangrene - soft tissue ... 2014:chap 137. Pasternack MS, Swartz MN. Cellulitis, necrotizing fasciitis, and subcutaneous tissue infections. In: Bennett JE, Dolin ...

  10. Staph Infections

    Science.gov (United States)

    ... Culture Household Safety: Preventing Cuts Dealing With Cuts Osteomyelitis Tetanus First Aid: Skin Infections Toxic Shock Syndrome ... Abscess Paronychia Dealing With Cuts and Wounds Cellulitis Osteomyelitis Impetigo Staph Infections MRSA Cuts, Scratches, and Scrapes ...

  11. Diabetic foot ulceration with osteomyelitis: the importance of early detection

    OpenAIRE

    Tranter, Jennifer; McIntosh, Caroline

    2008-01-01

    This case study explores the\\ud management of a chronic diabetic\\ud foot ulcer complicated by severe\\ud soft tissue infection (cellulitis) and\\ud bony infection (osteomyelitis) in a\\ud patient with type 2 diabetes.

  12. Bacterial Nasal Infections

    Science.gov (United States)

    ... vestibule. Nasal furuncles may develop into a spreading infection under the skin (cellulitis) at the tip of the nose. A doctor becomes concerned about infections in this part of the face because veins ...

  13. 75 FR 10165 - New Animal Drugs; Change of Sponsor

    Science.gov (United States)

    2010-03-05

    ... skin and soft tissue infections including cellulitis, pyoderma, dermatitis, wound infections, and... infections (cystitis) due to susceptible strains of Escherichia coli, Proteus mirabilis, and S. aureus. (ii) Cats. For the treatment of skin and soft tissue infections including abscesses, wound...

  14. Streptococcal Infections

    Science.gov (United States)

    ... red rash on the body. Impetigo - a skin infection Toxic shock syndrome Cellulitis and necrotizing fasciitis (flesh-eating disease) Group B strep can cause blood infections, pneumonia and meningitis in newborns. A screening test ...

  15. Erythema multiforme

    Science.gov (United States)

    ... liver (hepatitis) Permanent skin damage and scarring Skin infection ( cellulitis ) When to Contact a Medical Professional Go to ... 2009:chap 52. Read More Allergic ... Conditions Skin Infections Browse the Encyclopedia A.D.A.M., Inc. ...

  16. Scalded skin syndrome

    Science.gov (United States)

    ... Severe bloodstream infection ( septicemia ) Spread to deeper skin infection ( cellulitis ) When to Contact a Medical Professional Call your provider or go to the emergency room if you have symptoms of this disorder. Prevention ... Alternative Names Ritter disease; Staphylococcal ...

  17. Abscess

    Science.gov (United States)

    ... For Kids For Parents MORE ON THIS TOPIC Cellulitis Wound Healing and Care Peritonsillar Abscess Immune System Appendicitis Paronychia Staph Infections MRSA Contact Us Print Resources Send to a ...

  18. Lymphadenitis

    Science.gov (United States)

    ... Complications Untreated lymphadenitis may lead to: Abscess formation Cellulitis (a skin infection) Fistulas (seen in lymphadenitis that is due to ... infection. Alternative Names Lymph node infection; Lymph gland infection; Localized ... Protein in diet Sepsis Swollen lymph nodes ...

  19. An investigation of the possibility to replace the rabbit pyrogen test by an in vitro test

    NARCIS (Netherlands)

    Gommer AM; Donders LAM; LGM

    1998-01-01

    The classical test for the detection of pyrogenic contaminations in pharmaceuticals is the rabbit pyrogen test. The most frequently occuring and most important pyrogenic contamination in biological and biotechnological pharmaceutical preparations are bacterial endotoxins, originating from the cellul

  20. La genomica animale: biodiversità, qualità dei prodotti, salute umana e benessere animale

    OpenAIRE

    Biagini, Tommaso; Bueno, Susana; Chillemi, Giovanni

    2011-01-01

    La genomica è la disciplina scientifica che studia la struttura, la funzione e l’evoluzione del genoma di una specie. Questa scienza cerca di spiegare come sono programmate le cellule di individui diversi investigando l’intero patrimonio genetico. Inoltre studia anche cellule di uno stesso individuo le quali, pur avendo lo stesso genoma, possono avere forma e funzione molto differenti, come ad esempio un neurone ed una cellula di tessuto epatico. La comprensione delle complesse relazioni tra ...

  1. GENOMICA ANIMALE: BIODIVERSITÀ, QUALITÀ DEI PRODOTTI, SALUTE UMANA E BENESSERE ANIMALE

    OpenAIRE

    Bueno, Susana; Chillemi, Giovanni

    2012-01-01

    La genomica è la disciplina scientifica che studia la struttura, la funzione e l’evoluzione degli acidi nucleici di una specie a livello globale, appunto “genomico”. Questa scienza cerca di spiegare sia come siano programmate le cellule di individui diversi sia come cellule di uno stesso individuo, pur avendo lo stesso genoma, possano avere forma e funzione molto differenti (ad esempio un neurone e una cellula di tessuto epatico) sia come modificazionidel genoma possano comportare aberrazioni...

  2. La genomica animale: biodiversità, qualità dei prodotti, salute umana e benessere animale

    OpenAIRE

    Chillemi, Giovanni; Bueno, Susana; Prosperini, Gianluca; Mancini, Giordano

    2010-01-01

    La genomica studia struttura, funzione ed evoluzione del patrimonio genetico degli esseri viventi, cercando di spiegare come sono programmate le cellule di individui diversi, attraverso l’esplorazione dell’intero patrimonio genetico. Inoltre la genomica studia anche cellule di uno stesso individuo le quali, pur avendo lo stesso genoma, possono avere forma e funzione molto differenti, come ad esempio un neurone ed una cellula di fegato. La comprensione delle complesse relazioni che esistono tr...

  3. Studying a disease with no home--lessons in trial recruitment from the PATCH II study.

    LENUS (Irish Health Repository)

    Thomas, Kim S

    2010-01-01

    Cellulitis is a very common condition that often recurs. The PATCH II study was designed to explore the possibility of preventing future episodes of cellulitis, with resultant cost savings for the NHS. This was the first trial to be undertaken by the UK Dermatology Clinical Trials Network. As such, it was the first to test a recruitment model that involved many busy clinicians each contributing just a few patients.

  4. Infectious Complications of Noncombat Trauma Patients Provided Care at a Military Trauma Center

    Science.gov (United States)

    2010-05-01

    the median age was 38 and 22C’f \\\\ere female. Pulmonary infections were present 1n.f.2cr of pallenh. 2 40(- had cellulitis and wound infections ... infection , and celluliti ’> (Table Ill ). Cumulative pneumonia rates in trauma and burned ventilated patients, respecti\\ ely, are presented with...hospiwllengths of ’ltay (lOS>. and to die (p < 0.05). Multivariate analysis reve~lled associations between infection and hospital LOS. pree·\\isting

  5. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    OpenAIRE

    Gómez-Duarte, Oscar G.

    2014-01-01

    Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratori...

  6. Identification and functional analysis of intestinal stem cell genes in homeostasis and cancer

    OpenAIRE

    2013-01-01

    El primer capítulo de esta tesis describe el estudio de células madre intestinales (CMIs) y su relación con el cáncer de colon. Describimos los perfiles de expresión génica de las distintas poblaciones intestinales utilizando la expresión del receptor EphB2. Esto nos permitió describir la firma genética de las CMIs. Observamos que los tumores de colon con altos niveles de expresión de la firma genética de CMI tienen mayor probabilidad de recaer después de terapia. Además de est...

  7. Il lungo viaggio dell’Orthomixovirus A/goose/Guangdong/2/96(H5N1

    Directory of Open Access Journals (Sweden)

    Guglielmo Gargani

    2007-06-01

    Full Text Available INTRODUZIONE La peste aviaria ed i virus dell’influenza Nel 1878 E.Perroncito1 descrisse una grave malattia gastro-intestinale dei polli a carattere epidemico, che denominò peste aviaria; nel 1901 Centanni e Savonuzzi, mediante prove di filtrazione, ne dimostrarono l’origine virale. Oltre mezzo secolo più tardi, nel 1955, le migliorate metodiche virologiche misero in stretta relazione questo virus con il tipo A del virus influenzale; ambedue furono classificati qualche anno dopo come Orthomixovirus, tipo A. Fra questi virus esistono strette affinità virologiche e percorsi epidemiologici legati fra loro, ma la sintomatologia intestinale della peste aviaria è ben diversa da quella respiratoria dell’uomo e di qualche altro mammifero. Nel 1931 Shope

  8. From pathogen defence to food allergy; the multiple facets of the mucosal immune system

    OpenAIRE

    Perrier, Clémentine; Corthésy, Blaise

    2008-01-01

    Le système immunitaire associé aux muqueuses intestinales doit être capable de différencier les antigènes inoffensifs tels que la nourriture ou les bactéries commensales des microorganismes potentiellement dangereux. Cet aspect est essentiel pour le maintien de l’homéostase intestinale et fait l’objet du travail présenté ici. Dans un premier projet, les propriétés protectrices de la protéine appelée pièce sécrétoire (SC) ont été étudiées. SC est une protéine connue pour le transport des immun...

  9. Potencialidad probiótica de lactobacilos con capa S : Estudios sobre la inocuidad, efecto antimicrobiano y capacidad inmunomodulatoria de Lactobacillus kefiri

    OpenAIRE

    Carasi, Paula

    2014-01-01

    El tracto gastrointestinal de los mamíferos contiene una gran cantidad de microorganismos, microbiota, con los que se establece una relación simbiótica. Los desbalances de la misma, disbiosis, tienen consecuencias nocivas para el huésped y puede contribuir al desarrollo de enfermedades inflamatorias intestinales. El uso de microorganismos probióticos es una de las estrategias que se encuentran en desarrollo para intentar restaurarla o fortalecerla. El Kefir es un alimento descripto...

  10. Role of gut commensal microbiota regulating colonic sensory-related systems

    OpenAIRE

    Aguilera Pujabet, Mònica

    2015-01-01

    La microbiota comensal del intestino se considera un factor clave en la homeostasis gastrointestinal. Las alteraciones funcionales gastrointestinales (síndrome del intestino irritable, SII) y las enfermedades inflamatorias intestinales (EII) se han relacionado con alteraciones de la microbiota comensal (disbiosis). Estos pacientes muestran una activación inmune local anormal, con respuestas motoras y sensoriales alteradas, que en el SII se traducen en estados de hipersensibilidad visceral. El...

  11. Effect of Diethylene Glycol Monomethyl Ether (DiEGME) and Triethylene Glycol Monomethyl Ether (TriEGME) on Microbial Contaminants in Aviation Fuel

    Science.gov (United States)

    2010-03-01

    resinae (ATCC # 20495), and Yarrowia (Candida) tropicalis (ATCC # 20336). P. aeruginosa is a type of bacteria, C. resinae is a fungus, and C. tropicalis...The C. resinae originated from an aircraft fuel tank and was deposited by J. J. Marshall from the NLABS collection in 1977. The C. tropicalis was...species, a Pseudomonas species, Bacillus licheniformis, Clostridium intestinale, Rhodococcus equi, and Hormoconis (Cladosporium) resinae . All are bacteria

  12. Sirkadiese fluktuasies in serumserotonienkonsentrasies van normale gesonde mans

    Directory of Open Access Journals (Sweden)

    Editorial Office

    1993-07-01

    Full Text Available Sirkadiese sekresiepatrone vir bykans alle hormone/neuro-oordragstowwe is welbekend en hou in vele gevalle biologies onderling verband. Serotonien (5-Hidroksitriptamien, 5-HT kom wydverspreid sentraal asook perifeer in die menslike liggaam voor (pineaalklier, raphékerne van die breinstam, serotoninergiese senuweevesels van enteriese pleksusse, bloedvate en in bloedplaatjies. Meer as 90% van die serotonien in die menslike liggaam kom egter in die enterochromaffienselle van die gastro-intestinale kanaal voor.

  13. Diversidad intraespecífica y factores de virulencia en el “complejo de especies de Aeromonas hydrophila” (A. Hydrophila, A. Salmonicida, A. Bestiarum).

    OpenAIRE

    2013-01-01

    [spa] El género Aeromonas está constituido actualmente por 26 especies reconocidas, algunas de las cuales incluyen varias subespecies. Son habitantes ubicuos del agua dulce, pero también de aguas cloradas, salobres y marinas. Se han obtenido cepas de Aeromonas de una amplia variedad de alimentos, y se han aislado de muestras clínicas. Algunas especies de Aeromonas son causantes de infecciones intestinales y extraintestinales aunque los mecanismos por los que causan diarreas bacterianas no ...

  14. Rischi connessi al consumo di OGM: un modello animale

    Directory of Open Access Journals (Sweden)

    M. Orsini

    2003-05-01

    Full Text Available

    Obiettivi: materie prime e derivati da organismi geneticamente modificati (OGM sono autorizzati e regolamentati sia per il consumo umano, che per quello animale. Sono stati svolti da alcuni autori lavori che evidenziano la permeabilità della barriera intestinale di mammiferi a molecole di DNA di dimensioni superiori ad 1 kB. Tali molecole (non necessariamente provenienti da OGM una volta attraversata la barriera rimangono nei tessuti, fino alla loro completa degradazione. Non ci sono comunque prove di funzionalità del DNA ingerito e recuperato nei tessuti. Lo scopo è stato quello di valutare la presenza di DNA, in tessuti di pesci di allevamento, nutriti con mangimi a base di soia.

    Metodi: campioni di mangime ed esemplari di pesci sono stati raccolti in alcuni allevamenti del centro Italia. Il contenuto di soia OGM nei mangimi è stato quantificato mediante real time PCR. Frammenti di vari organi sono stati prelevati dagli esemplari e sottoposti ad estrazione di DNA. La presenza di frammenti di geni vegetali e transgeni è stata valutata mediante specifiche reazioni di PCR.

    Risultati: il 90% dei mangimi raccolti è risultato OGM positivo in misura variabile tra lo 0.5% ed il 60%. Sono stati analizzati 75 pesci (spigole e orate provenienti da 5 allevamenti. Non è stata riscontrata presenza di DNA esogeno nei tessuti analizzati tranne deboli segnali positivi nel tessuto intestinale. Questo dato è presumibilmente da imputare alle difficoltà di ottenere preparazioni di DNA intestinale prive di contaminazione alimentare.

    Conclusioni: i risultati ottenuti non rilevano attraversamento della parete intestinale da parte del DNA ingerito. Le motivazioni del disaccordo con i dati di letteratura possono essere ricercate nella scelta del modello ittico, distante dai mammiferi sia in termini filogenetici quanto in modalità alimentari. Il destino del DNA ingerito

  15. La synthèse et l'évaluation cytotoxicité de dérivées triazolic contre des lignes de cellule de mélanome B16 et une méthodologie étudient sur la synthèse d'éthers propargyl de leur correspondance propargyl des esters sans catalyseur et sous des irradiations à micro-ondes

    OpenAIRE

    Kalhor Monfared, Shiva,

    2014-01-01

    Medicinal chemistry is the application of chemical research techniques to the synthesis of pharmaceuticals. During this PhD project, we tried to synthesize small molecules based on terminal alkyne and propargyl alcohols. These molecules were prepared by departing from a simple aldehyde and by doing reactions like Bestmann-Ohira in order to prepare terminal alkynes or reaction with ethynylmagnesium bromide to prepare propargyl alcoholsB. These prepared small molecules were then subjected into ...

  16. Méthode de synthèse de la structure des convertisseurs multi-niveaux

    OpenAIRE

    Bartholoméüs, P.; P. Le Moigne; Rombaut, C.

    1997-01-01

    Une méthode d'étude des structures de convertisseurs réalisés à partir de cellules multi-niveaux à association de sources de tension en série est présentée. La notion de non réversibilité en puissance de la cellule de commutation est introduite. Elle permet la définition des structures de conversion réversibles ou non réversibles. À partir du sens de circulation du courant dans les cellules, il est possible de définir la caractéristique statique des interrupteurs réalisant les connexions entr...

  17. Periorbital cellulits--a mistaken diagnosis!

    Science.gov (United States)

    Fozard, Julia; Pandya, Nikila; Pulikot, Ashok; Fish, David; Malhotra, Raman; Lake, Damian

    2011-08-17

    A 12-year-old girl presented with a 1 week history of orbital swelling associated with granuloma, purulent discharge from the eye and preauricular and submandibular lymphadenopathy. Initial conventional treatment for presumed preseptal cellulitis was unsuccessful. Despite treatment with broad spectrum antibiotics, the preseptal cellulitis progressed to orbital cellulitis with restriction of eye movements in addition to the marked conjunctival chemosis and haemorrhage. A detailed history revealed she had been in close contact with newborn kittens at home and biopsy of the granuloma demonstrated Bartonella species, confirming the diagnosis of cat scratch disease. The child received a course of appropriate oral and topical antibiotics and steroids. Unfortunately eyesight in the right eye remains poor on follow-up.

  18. Typical tumors of the petrous bone; Typische Tumoren des Felsenbeins

    Energy Technology Data Exchange (ETDEWEB)

    Ahlhelm, F.; Mueller, U. [Kantonsspital Baden AG, Abteilung fuer Neuroradiologie, Institut fuer Radiologie, Baden (Switzerland); Ulmer, S. [Medizinisch-Radiologisches Institut, Zuerich (Switzerland)

    2014-04-15

    In the region of the petrous bone, inner acoustic canal and cerebellopontine angle, a variety of different tissues can be found, such as bony, epithelial, neural and vascular structures. Tumorous or tumor-like lesions, vascular or bony malformations or other pathologies can therefore be found in all of these areas. We discuss various frequently occurring tumorous or tumor-like pathologies including congential lesions, such as mucoceles, inflammatory disorders including osteomyelitis, pseudotumors and Wegener's granulomatosis. Benign non-neoplastic lesions, such as cholesteatoma, cholesterol granuloma, epidermoid and benign neoplastic tumors, such as the most commonly found vestibular schwannoma, meningeoma, paraganglioma, vascular pathologies and finally malignant lesions, such as metastasis, chordoma or chondrosarcoma and endolymphatic sac tumor (ELST) are also discussed. The emphasis of this article is on the appearance of these entities in computed tomography (CT) and more so magnetic resonance imaging (MRI), it provides key facts and typical images and discusses possibilities how to distinguish these pathologies. (orig.) [German] In der Region des Felsenbein, inneren Gehoerkanals und Kleinhirnbrueckenwinkels findet sich eine Vielzahl an unterschiedlichen Gewebearten inklusive knoechernes, epitheliales, nervales und vaskulaeres Gewebe. Tumoren oder tumoraehnliche Laesionen, ossaere oder vaskulaere Pathologien koennen entsprechend dort gefunden werden. Wir diskutieren verschiedene Tumoren oder tumoraehnliche Pathologien inklusive angeborene Laesionen wie Muko- und Meningozelen, entzuendliche Veraenderungen wie die Osteomyelitis, Pseudotumoren, die Wegener-Granulomatose, nichtneoplastische Tumoren wie das Epidermoid, Cholesteatom oder Cholesterolgranulom und gutartige neoplastische Tumoren wie das am haeufigsten zu findende Vestibularisschwannom, das Paragangliom und das Meningeom, Gefaessprozesse/-pathologien und schliesslich maligne Laesionen wie Metastasen

  19. Development of a Dynamic Biomechanical Model for Load Carriage: Phase III Part C1: Pressure and Force Distribution Measurement for the Design of Waist Belts in Personal Load Carriage Systems

    Science.gov (United States)

    2005-08-01

    d’étalonnage, qui dépendent de la surface efficace de la cellule et du coefficient de frottement utilisés pour l’orientation de chaque capteur sur place, ont...utilisant la surface utile des capteurs à cellules du TekscanMC et le coefficient de frottement longitudinal a été démontrée. Son application est...surface. Calibration factors, a factor of effective sensel area and a frictional coefficient for the in situ orientation of each sensor were calculated

  20. CANCER BRONCHO-PULMONAIRE ET thérapeutique

    OpenAIRE

    Chater, Asma

    2014-01-01

    Le cancer du poumon est une maladie caractérisée par une croissance incontrôlée des cellules dans les tissus du poumon. Si elle n'est pas traitée, cette croissance peut se propager au-delà du poumon dans un processus appelé métastase dans les tissus voisins et, éventuellement, dans d'autres parties du corps. La plupart des cancers qui commencent dans les poumons, connue sous le nom cancers du poumon primaires, sont des carcinomes qui dérivent de cellules épithéliales. Les principaux types de ...

  1. Des panneaux Solaires Haut Rendement

    OpenAIRE

    Adaine, Abdoulwahab

    2016-01-01

    National audience; Les cellules solaires sont généralement basées sur une seule jonction P-N et utilisent généralement le silicium sous forme cristalline comme matériau semi-conducteur. Ce pendant avec une seule jonction P-N, la cellule solaire ne peut tout simplement pas absorber la totalité du spectre solaire, et on se heurte donc à une limite maximale du rendement qui est d’environ 25%. Afin d'essayer de dépasser cette limite, les recherches se tournent vers l'utilisation d'autres matériau...

  2. Méthode de synthèse de la structure des convertisseurs multi-niveaux

    Science.gov (United States)

    Bartholoméüs, P.; Le Moigne, P.; Rombaut, C.

    1997-09-01

    In this paper a study of the multilevel converters' structures is presented. Multilevel cells with series connection of voltage sources are considered. The notion of power reversibility of the cell is introduced. It allows for the definition of reversible and non-reversible converter structures. The knowledge of the sign of the current which circulates in the cell permits the definition of the static characteristics of the switches involved in the connection between the different points of the voltage source and the current source. Two configurations of the cells are studied. For each one, the static characteristic of each switch is determined. For the first configuration, called “N_c-switch cell", each point of the voltage source is connected to the current source by one switch only. The second one is constituted of a stacking-up of switching elementary cells. It is called “elementary cell association structure". In this case, several switches are involved in each connection. Thanks to these two configurations, different cells have been developed, and they allow for the definition of new structures of rectifiers. Une méthode d'étude des structures de convertisseurs réalisés à partir de cellules multi-niveaux à association de sources de tension en série est présentée. La notion de non réversibilité en puissance de la cellule de commutation est introduite. Elle permet la définition des structures de conversion réversibles ou non réversibles. À partir du sens de circulation du courant dans les cellules, il est possible de définir la caractéristique statique des interrupteurs réalisant les connexions entre un des différents points de la source de tension et la source de courant. Deux trames d'interrupteurs sont considérées. Pour la première, nommée “cellule à N_c interrupteurs", les connexions sont réalisées par un seul interrupteur à la fois. Pour la seconde, constituée d'un empilage de cellules élémentaires de commutation, et nomm

  3. Rhinocerebral mucormycosis: Race against time for surgeons

    Directory of Open Access Journals (Sweden)

    G C Rajkumar

    2016-01-01

    Full Text Available Rhinocerebral mucormycosis is a rare, aggressive, and rapidly progressive life-threatening opportunistic infection affecting the immunocompromised patients. It manifests as facial swelling, cellulitis, nasal obstruction and discharge, large areas of tissue destruction and necrosis, orbital cellulitis, ptosis, proptosis, and vision loss in advanced cases. The pathognomonic feature of the disease is the presence of invasive mycelium in the tissues. A case series on four patients diagnosed with rhinocerebral mucormycosis is presented. Diabetic ketoacidosis was the common risk factor observed in all the three patients. It was concluded that early diagnosis and aggressive medical and surgical treatment are necessary for decreasing the high mortality rate of the infection.

  4. What Is Inflammatory Breast Cancer? Revisiting the Case Definition

    Science.gov (United States)

    2010-03-03

    d’orange 7 14% Warmth 6 12% Thick mass 3 6% Other 12 24% Initial clinical diagnoses for 10 women were infection , including nine diagnoses of mastitis...and one of cellulitis (Table 3). These 10 women were treated with antibiotic therapy for up to 5 months prior to a definitive diagnosis of breast...worry about 1 2% Fibrous mass 1 2% Cellulitis 1 2% Hematoma secondary to trauma 1 2% A discrete mass and thickening of the skin was the most

  5. Herida antebraquial infectada por Aeromonas hydrophila

    OpenAIRE

    1995-01-01

    Se presenta un caso de celulitis por Aeromonas hydrophila, en un paciente de 23 años, tras una herida antebraquial producida en el medio acuático. La celulitis se resolvió mediante desbridamiento agresivo y quimioterapia. En los controles posteriores no se han apreciado déficits funcionales tras la infección. A case of Aeromonas hidrophila cellulitis developped in a 23-year-old patient, after aquatic environment forearm wound is presented. His cellulitis was effectively resolve...

  6. Clothe the Soldier Prototype Modular Load Carriage System Design Assessment using the APLCS Load Carriage Simulator

    Science.gov (United States)

    2006-03-01

    hanches; pressions moyennes sur la peau , pressions de crête et forces sur l’avant et l’arrière des épaules, ainsi que le sac supérieur et inférieur...cellule dynamométrique tridimensionnelle au niveau des hanches; pressions moyennes sur la peau , pressions de crête et forces sur l’avant et l’arrière...personne; les forces et les moments par rapport à une cellule dynamométrique tridimensionnelle au niveau des hanches; pressions moyennes sur la peau

  7. Clothe the Soldier Prototype K1 Load Carriage System Design Assessment using the APLCS Load Carriage Simulator

    Science.gov (United States)

    2006-03-01

    une cellule dynamométrique tridimensionnelle à 6 degrés de liberté au niveau des hanches; pressions moyennes sur la peau , pressions de crête et...cellule dynamométrique tridimensionnelle à 6 degrés de liberté au niveau des hanches; pressions moyennes sur la peau , pressions de crête et forces sur...sur le plan vertical (z). La préoccupation principale concernant sa conception étaient les forces importantes appliquées sur la surface de la peau

  8. Preliminary report on the intestinal parasites and their diversity in captive Chinese alligators.

    Science.gov (United States)

    Zhao, Jinhong; Zhou, Yongkang; Wang, Shaosheng; Tu, Genjun; Tang, Xiaoniu; Wu, Xiaobing

    2014-10-20

    Objetivo: Aunque los parásitos intestinales son comúnmente detectados en los cocodrilos salvajes o en criados en cautividad en otras partes del mundo, existen muy pocos informes el caso concreto del caimán chino criado en cautividad (Alligator sinensis), ya que sólo están distribuidos en las zonas del sur del río Yangtze. El presente trabajo fue realizado para investigar los parásitos intestinales y su diversidad en las especies de cocodrilo chino. Métodos: En mayo y octubre de 2013, se recopilaron aleatoriamente un total de 328 muestras fecales de caimanes chinos en cautividad de un centro de cría en el sur de la provincia de Anhui. Resultados: Fueron identificados tres géneros de protozoos (Entaoeba, Eimeria e Isospora), cinco géneros de nematodos (Ascaris, Dujardin Ascaris, Capillaria, Toxocara y Strongylus), dos géneros de trematodos (Echinostoma y Clonorchis) y dos familias de trematodos (Schistosomatidae y Cryptogonimidae), de los cuales la mayor prevalencia correspondió a Dujardin Ascaris y producían la mayor tasa de infección (14,33%); entaoeba se situó en el segundo puesto (13,11%). El número de especies, índice de riqueza, índice de diversidad y de equitatividad fue superior en los meses de julio y agosto, y éstos, relativamente más para caimanes jóvenes y sub-adultos. Conclusiones: Nuestros resultados apuntan la prevalencia de la infección por parásitos intestinales en caimanes chinos en cautividad y ello exige nuestra atención, ya sea para controlar o prevenir la propagación de la enfermedad parasitaria intestinal a los seres humanos, o para la conservación de esta especie en peligro de extinción.

  9. The surgical approach to near-total small bowel infarction in a patient with massive portomesenteric thrombosis. Case report.

    Science.gov (United States)

    Occhionorelli, Savino; La Manna, Alessandra; Stano, Rocco; Morganti, Lucia; Vasquez, Giorgio

    2016-05-23

    L’ischemia mesenterica acuta causa una riduzione della circolazione mesenterica e di conseguenza un’ischemia intestinale; la trombosi venosa mesenterica è classificata tra le forme più rare e letali di ischemia mesenterica acuta, in quanto responsabile di un tasso di mortalità del 13-50%, a causa dell’assenza di segni e sintomi iniziali specifici ed un conseguente ritardo diagnostico. Spesso essa si rende evidente quando il quadro di peritonite è già in evoluzione, per cui l’unico atteggiamento possibile è chirurgico. La letteratura non offre linee guida precise sul trattamento dell’infarto intestinale, che solitamente è basato sulle condizioni cliniche del singolo paziente e sull’estensione del processo ischemico. Gli autori riportano il caso di un paziente di 76 anni che presenta un infarto intestinale massivo, causato da una trombosi del sistema portomesenterico, trattato chirurgicamente con resezione, anastomosi e confezionamento di una laparostomia, per monitorare l’eventuale evoluzione necrotica e la vitalità dell’intestino e dell’anastomosi. La letteratura propone di trattare la trombosi venosa mesenterica con anticoagulanti associati o meno al trattamento chirurgico. Se, da una parte, c’è un’uniformità di opinioni sul tipo e la durata della terapia anticoagulante, dall’altra non vi sono linee guida precise ed indicazioni standard sul trattamento chirurgico e, soprattutto, sulla gestione del “second-look” chirurgico, spesso necessario per valutare la vitalità dell’intestino residuo. Gli autori propongono di confezionare una laparostomia per agevolare il “second-look”, in quanto è dimostrato aumentare la sopravvivenza in pazienti con condizioni cliniche critiche e con rischio aumentato di sviluppare complicanze derivanti dalla re-anestesia e dalla re-laparotomia.

  10. Relación “Saneamiento Básico y Prevalencia de Entero parásitos” en estudiantes del Colegio German Busch, La Paz - 2013

    Directory of Open Access Journals (Sweden)

    Leandro Ribeiro França

    2013-12-01

    Full Text Available Las infecciones parasitarias intestinales son enfermedades que afectan a una gran parte de la población infantil en los países más subdesarrollados y en vías de desarrollo y en muchos casos se convierte en una causa de muerte. El objetivo de este estudio fue establecer un paralelo entre las condiciones sanitarias aportadas por la Comunidad Minera Bolsa Negra - La Paz - Bolivia y la presencia de enteroparasitos en niños entre 07 y 12 años de la referida comunidad. Se aplicó en este proyecto un método de estudio observacional descriptivo, a través del estudio de casos y controles. En cuanto a los resultados, mediante el análisis de materia fecal de los niños parte del universo de la investigación, donde encontró diferentes formas evolutivas de parásitos intestinales, con 100% de prevalencia para los géneros Blastocystis hominis , Giardia lamblia y Entamoeba coli. También se analizó el grado de conocimiento por parte de las madres de los niños que participaron en la investigación que indica un mal conocimiento general en lo que respecta a servicios de saneamiento básico y la higiene personal. También se presentaron las formas y medidas para la prevención de enfermedades relacionadas con los parásitos intestinales encontrados.

  11. Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin.

    Science.gov (United States)

    Kačániová, Miroslava; Vukovič, Nenad; Horská, Elena; Salamon, Ivan; Bobková, Alica; Hleba, Lukáš; Fiskelová, Martina; Vatľák, Alexander; Petrová, Jana; Bobko, Marek

    2014-01-01

    In the present study, the antimicrobial and antiradical activities of 15 essential oils were investigated. The antimicrobial activities were determined by using agar disc diffusion and broth microdilution methods against Clostridium genus and antioxidant properties of essential oils by testing their scavenging effect on DPPH radicals activities. We determined the antibacterial activity of Clostridium butyricum, Clostridium hystoliticum, Clostridium intestinale, Clostridium perfringens and Clostridium ramosum. We obtained the original commercial essential oils samples of Lavandula angustifolia, Carum carvi, Pinus montana, Mentha piperita, Foeniculum vulgare Mill., Pinus sylvestris, Satureia montana, Origanum vulgare L. (2 samples), Pimpinella anisum, Rosmarinus officinalis L., Salvia officinalis L., Abies alba Mill., Chamomilla recutita L. Rausch and Thymus vulgaris L. produced in Slovakia (Calendula a.s., Nova Lubovna, Slovakia). The results of the disk diffusion method showed very high essential oils activity against all tested strains of microorganisms. The best antimicrobial activity against C. butyricum was found at Pimpinella anisum, against C. hystoliticum was found at Pinus sylvestris, against C. intestinale was found at Satureia hortensis L., against C. perfringens was found at Origanum vulgare L. and against C. ramosum was found at Pinus sylvestris. The results of broth microdilution assay showed that none of the essential oils was active against C. hystoliticum. The best antimicrobial activity against C. butyricum was found at Abies alba Mill., against C. intestinale was found at Abies alba Mill., against C. perfringens was found at Satureia montana and against C. ramosum was found at Abius alba and Carum carvi. Antioxidant DPPH radical scavenging activity was determined at several solutions of oil samples (50 μL.mL(-1)-0.39 μL.mL(-1)) and the best scavenging effect for the highest concentration (50 μL.mL(-1)) was observed. The antioxidant properties

  12. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    Science.gov (United States)

    Gómez-Duarte, Oscar G.

    2014-01-01

    Resumen Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratorios clínicos de centros de salud. Estudios recientes han reportado la detección de E. coli patógenas intestinales en Colombia, siendo la E. coli enterotoxigénica la cepa más frecuentemente asociada a diarrea en niños menores de 5 años. Otros patógenos detectados en estos pacientes incluyen las E. coli enteroagregativa, enteropatógena, productora de toxina Shiga, y de adherencia difusa. Con base en estudios que reportan la presencia de E. coli productora de toxina Shiga y E. coli enteroagregativa en carnes y vegetales en supermercados, se cree que productos alimentarios contaminados contribuyen a la transmisión de estos patógenos y a la infección del huésped susceptible. Más estudios son necesarios para evaluar los mecanismos de transmisión, el impacto en la epidemiologia de la EDA, y las pautas de manejo y prevención de estos patógenos que afectan la población pediátrica en Colombia. PMID:25491457

  13. Treatment plant design using natural products for the purification of surface waters in Burkina Faso

    OpenAIRE

    López Grimau, Víctor; Smith, Tarik; Amante García, Beatriz; Heras, Francisco

    2013-01-01

    La climatología semi-árida de Burkina Faso (África occidental) es propensa a variaciones estacionales extremas, encadenando largos periodos de sequía con fuertes lluvias concentradas entre los meses de mayo y octubre. Las deficiencias tanto en el suministro de agua como en su calidad, especialmente en zonas rurales, supone la principal causa de enfermedades causadas por parásitos intestinales, con particular incidencia en la población infantil. Este estudio está locali...

  14. Conducta alimentaria de poblaciones de triatoma dimidiata (hemiptera: reduviidae: triatominae) en una zona endémica y sus implicaciones epidemiológicas

    OpenAIRE

    Farfán-García, Ana E.; Angulo-Silva, Víctor M.

    2012-01-01

    Objetivo Determinar la conducta alimentaria de Triatoma dimidiata en hábitats domiciliarios y extradomiciliarios en una zona endémica de Santander, Colombia. Materiales y métodos Mediante la técnica de ELISA, se procesaron 367 contenidos intestinales de insectos capturados en zonas rurales de los municipios de Capitanejo y Macaravita. Estos fueron procesados por medio de la técnica de ELISA, con 12 antisueros policlonales anti-especie animal específicos. Los hospederos de T. dimidiata fueron ...

  15. Prevalencia del Enteroparasitismo en escolares de comunidades nativas del Alto Marañon, Amazonas, Perú

    OpenAIRE

    Nicanor Ibáñez H.; César Jara C.; Antenor Guerra M; Enrique Díaz L

    2004-01-01

    Objetivos: Determinar la prevalencia de infección por protozoarios y helmintos intestinales y su relación con el sexo, localidad de procedencia y grupo etáreo, en escolares nativos de la zona selvática del Alto Marañón, provincia de Bagua, departamento de Amazonas, Perú. Materiales y métodos: En este estudio transversal-observacional se seleccionó a los colegios representativos de la mencionada región lográndose examinar las muestras fecales de 1049 escolares de seis a 15 años de edad, entre ...

  16. Relación “Saneamiento Básico y Prevalencia de Entero parásitos” en estudiantes del Colegio German Busch, La Paz - 2013

    OpenAIRE

    Leandro Ribeiro França; Dr. Julio Cesar Luna Leyza

    2013-01-01

    Las infecciones parasitarias intestinales son enfermedades que afectan a una gran parte de la población infantil en los países más subdesarrollados y en vías de desarrollo y en muchos casos se convierte en una causa de muerte. El objetivo de este estudio fue establecer un paralelo entre las condiciones sanitarias aportadas por la Comunidad Minera Bolsa Negra - La Paz - Bolivia y la presencia de enteroparasitos en niños entre 07 y 12 años de la referida comunidad. Se aplicó en este proyecto...

  17. Modelos experimentales in vivo de enfermedad inflamatoria intestinal y cáncer colorrectal: Conceptos, modelos actuales y aplicabilidad In vivo experimental models of inflammatory bowel disease and colorectal cancer

    OpenAIRE

    J. Mañé Almero

    2007-01-01

    No existe un modelo animal ideal para el estudio de patologías humanas como la EII o el CCR. En la última década, a los modelos inducidos por agentes exógenos se han incorporado los animales manipulados genéticamente. Los modelos experimentales de EII reproducen procesos inflamatorios intestinales heterogéneos, al igual de sucede en el ser humano. Mientras que los modelos de CCR remedan las mutaciones halladas en el hombre aunque con repercusiones fenotípicas diferentes. En ambos casos, estos...

  18. Fármacos que inhiben el factor de necrosis tumoral α y embarazo

    OpenAIRE

    Cristian Simon, Petru; Vallano Ferraz, Antonio

    2013-01-01

    Pregunta: ?Es segura la administración de los fármacos que inhiben el factor de necrosis tumoral a (TNF-a) durante el embarazo? Respuesta: En los últimos años se han desarrollado medicamentos que inhiben el TNF-a, porque esta citocina tiene un efecto inflamatorio que condiciona el proceso patológico de diversas enfermedades autoinmunitarias sistémicas, como artritis reumatoide, psoriasis, enfermedades inflamatorias intestinales y otras. Actualmente existen en el mercado farmacéutico 5 fármaco...

  19. Mecanismos de toxicidad y permeabilidad transepitelial de toxinas marinas y de agua dulce

    OpenAIRE

    Fernández Martínez, Diego Alberto

    2015-01-01

    La presente tesis doctoral aporta datos experimentales que permiten comprender mejor los efectos que las toxinas marinas Palitoxina (PLTX), Ácido Okadaico (OA), Dinofisistoxina 1 y 2 (DTX-1 y DTX-2) y la toxina de agua dulce Cilindrospermopsina (CYN), pueden ejercer sobre la salud humana y animal. Con esta finalidad se investiga la citotoxicidad y las alteraciones citomorfológicas que estos compuestos desencadenan en células intestinales, hepáticas y nerviosas. También se evalú...

  20. Función barrera epitelial en un modelo de disfunción intestinal inducido por parasitosis con Trichinella spiralis en la rata

    OpenAIRE

    Fernández Blanco, Joan Antoni

    2013-01-01

    La función barrera intestinal constituye la primera línea de defensa del tracto digestivo. Ésta se ve condicionada por el transporte hidroelectrolítico, la permeabilidad y la motilidad intestinales. Alteraciones de estas funciones favorecen la estimulación continua, por antígenos y microorganismos luminales, del sistema inmune local llevando a estados inflamatorios más o menos crónicos. Estos cambios parecen caracterizar diversas patologías inflamatorias y funcionales gastrointestinales, incl...

  1. Haiti: Neglected Infectious Diseases infographic Title: Haití: Infografía enfermedades olvidadas infecciosas

    OpenAIRE

    Agustin Cáceres

    2012-01-01

    In Haiti, the IDB and its partners integrate health, water and sanitation to fight intestinal parasites and other Neglected Infectious Diseases. This Infographic promotes the IDB's activities in Haiti and provides general information related to these diseases.Abstract: En Haití, el BID y sus socios integran la salud, agua y saneamiento para combatir los parásitos intestinales y otras enfermedades infecciosas desatendidas. Esta Infografía promueve las actividades del BID en Haití y ofrece info...

  2. Trasplante intestinal en el paciente con nutrición parenteral domiciliaria Intestinal transplant in patients with parenteral nutrition at home

    OpenAIRE

    A. I. de Cos; C. Gómez Candela; C. Vázquez; M. López Santamaría; de Vicente, E

    2003-01-01

    El fracaso intestinal, bien sea por causa anatómica o funcional, condiciona el tratamiento con nutrición parenteral en niños o adultos que, como resultado de resecciones intestinales, alteración de la motilidad, enfermedad de microvellosidades u otras causas, presentan un intestino insuficiente para proveer sus necesidades en nutrientes y fluidos. Sin embargo, en sujetos con fallo intestinal irreversible el mantenimiento del soporte con nutrición parenteral domiciliaria no esta exento de comp...

  3. Influencia de distintos glúcidos y lípidos en la dieta sobre aspectos del metabolismo lipídico en la rata

    OpenAIRE

    López Jiménez, José Ángel

    1994-01-01

    Cuando se utilizan dietas isocalóricas, la modificación del tipo de grasa o el tipo de azúcar, no influye sobre el crecimiento, ni la ingesta, incluso cuando los glúcidos simples alcanzan valores del 30%. Solo en el caso de que el glúcido sea sacarosa se produce una disminución de la ingesta y del crecimiento, poniéndose de manifiesto un efecto negativo no solo a nivel metabólico, sino también del apetito, posiblemente a través de receptores intestinales, la existencia de una secuencia de … [...

  4. Estudio de las alteraciones del esmalte en la enfermedad celiaca

    OpenAIRE

    Bonet Coloma, Cristina

    2013-01-01

    La enfermedad celiaca (EC) es una enteropatía caracterizada por una intolerancia permanente al gluten, proteína existente en el trigo, centeno, cebada y avena que provoca una lesión severa de las vellosidades intestinales, y se normaliza tras su retirada de la dieta. La sintomatología varía de un paciente a otro dependiendo del daño de la mucosa intestinal. La presentación típica incluye diarrea, pérdida de peso, fatiga, distensión abdominal, vómitos, deficiencias nutricionales y anemia p...

  5. Efecto de los prebióticos sobre el metabolismo lipídico

    OpenAIRE

    Marti, A.; Moreno-Aliaga, M.J. (María Jesús); Martinez, J A

    2003-01-01

    Los prebióticos se definieron en 1995 como ingredientes alimentarios no digeribles que afectan de manera beneficiosa al hospedador estimulando el crecimiento o la actividad de una o varias bacterias del colon, y por tanto mejoran la salud. Se ha mostrado que la proliferación de bacterias determinadas mediante la fermentación de hidratos de carbono no digeribles, puede inhibir la colonización del intestino por patógenos, ejerciendo un efecto protector hacia los desordenes intestinales agudos o...

  6. Aislamiento de especies termotolerantes de Campylobacter de aguas fluviales utilizando dos métodos de colecta Isolation of thermotolerant species of Campylobacter from river water using two collection methods

    OpenAIRE

    Fernandez, H; L. OTTH; M. Wilson

    2003-01-01

    Campylobacter jejuni y C. coli son agentes zoonóticos de infecciones intestinales que pueden contaminar cuerpos de agua. Varios brotes de gastroenteritis por Campylobacter asociados al consumo de agua han sido descritos. En este estudio se compara el rendimiento de los métodos de la tórula de Moore (MSM) y de filtración por membrana para el aislamiento de Campylobacter en 181 muestras de agua obtenidas del curso urbano del río Calle-Calle. En el 24.3% de las muestras obtenidas por MSM y en el...

  7. Factores asociados a complicaciones post quirúrgicas en pacientes adultos con obstrucción intestinal mecánica en Bogotá, Colombia, período 2008 - 2014

    OpenAIRE

    Manrique Luna, Aura Carolina; Salazar García, Andrés Felipe

    2014-01-01

    Introducción: La obstrucción intestinal es una patología de alta prevalencia e impacto en los servicios de cirugía general a nivel mundial. El manejo de esta entidad puede ser médico o quirúrgico. Cuando se requiere intervención quirúrgica, se busca evitar el desarrollo de isquemia intestinal y resecciones intestinales; durante el postoperatorio, pueden existir complicaciones. El objetivo de este estudio es identificar los factores asociados al desarrollo de complicaciones post operatoria...

  8. Tratamiento nutricional del fallo intestinal y potenciales mecanismos de estimulación Nutritional management of intestinal failure and potential stimulation mechanisms

    OpenAIRE

    A. J. Pérez de la Cruz; R Moreno-Torres Herrera; C. Pérez Roca

    2007-01-01

    El Fallo Intestinal en sus formas graves representa una de las patologías de manejo más complejo, tanto en niños como adultos. En adultos las causas más frecuentes son la Pseudoobstrucción Intestinal Crónica y el Síndrome del Intestino Corto severo que sigue a las grandes resecciones intestinales, sobre todo las debidas a isquemia mesentérica masiva, en el marco de cardiopatías que cursan con fibrilación auricular. El tratamiento fundamental tras la estabilización del paciente, está represent...

  9. Parásitos zoonóticos en mascotas caninas y felinas de escolares suburbanos

    OpenAIRE

    Piacenza, G.; Jorge, S; Zubiri, Karina; Ceccarelli, Soledad; Ciarmela, María Laura; Pezzani, Betina Cecilia; Minvielle, Marta Cecilia

    2016-01-01

    Los animales que con mayor frecuencia se encuentran en hogares son los perros y los gatos. El contacto con estos animales produce un vínculo afectivo y ayuda a los niños en su desarrollo emocional. Sin embargo, esta convivencia puede poner a los integrantes de la familia en riesgo de contraer alguna infección zoonótica; como las causadas por parásitos intestinales como Toxocara sp., Ancylostoma caninum y Giardia sp., entre otras. Objetivo: identificar las especies de parásitos que presenta...

  10. Estudio de la modificación en la absorción de fármacos en giardiasis y nuevas estrategias de formulación

    OpenAIRE

    Vivancos Gómez, Verónica

    2016-01-01

    Giardia intestinalis es el agente causal de la giardiasis, una de las patologías intestinales más comunes en todo el mundo, cuya sintomatología principal es diarrea y malabsorción. La OMS indica que la prevalencia mundial es de 200 millones de individuos afectando especialmente a niños entre 2 y 12 años, los cuales son en su mayoría asintomáticos. Diversos estudios demuestran que existe un riesgo importante en la población infantil, pues la carencia de vitaminas y otros nutrientes que provoca...

  11. Les objectifs et les critères de sélection. La production laitière des ruminants traits

    OpenAIRE

    Barillet, Francis; Bonaiti, Bernard

    1992-01-01

    La sécrétion lactée, fonction originale et spécifique des mammifères, est adaptée qualitativement et quantitativement aux besoins de survie des jeunes, qui en sont exclusivement dépendants pendant une période plus ou moins longue. De ce fait, le lait est un milieu biologique complexe, qui représente l’élément nutritif du jeune, assure la croissance de la flore intestinale du nouveau-né et contribue à la transmission de l’immunité passive. La sélection des ruminants laitiers, dont la productio...

  12. Lesiones remotas ocasionadas por el síndrome isquemia-reperfusión en equinos, fisiopatología y alternativas terapéuticas

    OpenAIRE

    2009-01-01

    Las lesiones del síndrome isquemia y reperfusión  (I/R) en los diferentes cuadros fisiopatológicos de situaciones clínicas, así como también en procedimientos quirúrgicos de alta manipulación vascular y tisular, son de gran importancia en la medicina equina, por ello, la mayoría de estudios se han centrado en este tema, pues sus particularidades de especie aumentan la frecuencia de presentación de accidentes intestinales (White et ál., 1980; Moore et ál., 1995; Faleiros, 1997; Kooreman et ál....

  13. Contenido de alimento y metabolismo ceco-cólico en el tracto digestivo de poblaciones silvestres de iguana negra (Ctenosaura pectinata) en Morelos, México Cecum-colic content of food and metabolism in the digestive tract of wild population black lizard (Ctenosaura pectinata) in Morelos, Mexico

    OpenAIRE

    L Vélez-Hernández; MA Cobos-Peralta; JL Arcos-García

    2012-01-01

    Se colectaron cinco tractos digestivos de iguana negra (Ctenosaura pectinata) en estado silvestre en el estado de Morelos, México, para conocer la composición botánica de la dieta y el metabolismo ceco-cólico. Se observaron frotis realizados del contenido ceco-cólico para registrar la presencia de protozoarios, bacterias y parásitos intestinales existentes. Se obtuvo la media y desviación estándar de las características evaluadas. En el contenido ceco-cólico se identificaron las especies vege...

  14. Schistosomiasis: a review

    OpenAIRE

    Kendra L. Elwood; Fischer, Philip R.

    2014-01-01

    La schistosomiase, une infection parasitaire d'origine hydrique, est une maladie tropicale négligée trouvée plus souvent dans les régions tropicales et subtropicales du monde. En Afrique, deux formes dominantes de la maladie sont rencontrées, urogénitale et intestinale, due à Schistosoma haematobium et S. mansoni, respectivement. La morbidité de la maladie et de ses éventuelles complications à long terme dépassent celles de beaucoup d'autres maladies tropicales, comme le paludisme et la tuber...

  15. Aplicación de la PCR en tiempo real para la detección de patógenos en la industria alimentaria

    OpenAIRE

    Garrido Maestú, Alejandro

    2013-01-01

    Existe un gran número de bacterias patógenas que pueden afectar al ser humano al infectarse, este último, a través de los alimentos. Las manifestaciones clínicas pueden variar, desde simples molestias intestinales a la muerte en los casos más graves. Por esto, es cada vez más importante disponer de sistemas de detección que permitan evitar la introducción de estos microorganismos dentro de la cadena alimentaria. Por otro lado la importancia del desarrollo y aplicación de nuevos métodos no sól...

  16. OBTENCIÓN DE FIBRA DIETÉTICA NUTRICIONAL DE VALOR AGREGADO A PARTIR DE BAGAZO DE CAÑA.

    OpenAIRE

    LICONA AGUILAR, ANGELES IVETH

    2014-01-01

    La fibra dietética se reconoce cada vez más como un elemento importante para una nutrición sana; numerosas referencias respaldan esta aseveración en las que se ha demostrado no solo la importancia que la fibra tiene en la regulación de las funciones intestinales sino también para la prevención de algunas enfermedades. En este contexto, tiene sentido analizar la posibilidad de aprovechar la potencial utilización que brindan numerosos residuos agrícolas como fuente de fibra en una gran variedad...

  17. OBTENCIÓN DE FIBRA DIETETICA NUTRICIONAL DE VALOR AGREGADO A PARTIR DE BAGAZO DE CAÑA

    OpenAIRE

    LICONA AGUILAR, ANGELES IVETH

    2014-01-01

    La fibra dietética se reconoce cada vez más como un elemento importante para una nutrición sana; numerosas referencias respaldan esta aseveración en las que se ha demostrado no solo la importancia que la fibra tiene en la regulación de las funciones intestinales sino también para la prevención de algunas enfermedades. En este contexto, tiene sentido analizar la posibilidad de aprovechar la potencial utilización que brindan numerosos residuos agrícolas como fuente de fibra en una gran variedad...

  18. Estudio de los metabolismos protéico, fosfocálcico y magnésico en ratas con resección intestinal.

    OpenAIRE

    López-Aliaga, Inmaculada

    2011-01-01

    Las resecciones intestinales tienen repercusiones a nivel digestivo y metabólico. Cabe destacar el efecto negativo que la exclusión del íleon y parte de yeyuno tiene sobre la utilización nutritiva de proteína grasa y algunos minerales (calcio y fósforo). La reducción en la absorción de grasa va aparejada de un descenso en la utilización digestiva de la vitamina d y se incrementan las perdidas de vitamina d sintetizadas endogenamente, lo que repercute en la deficiente absorción de calcio y fós...

  19. Terapia nutricia en fístula enterocutánea; de la base fisiológica al tratamiento individualizado

    OpenAIRE

    Ameyalli Mariana Rodríguez Cano

    2014-01-01

    La fístula enterocutánea es la forma más común de las fístulas intestinales. Es una patología que obliga la estancia hospitalaria prolongada debido a complicaciones como desequilibrio hidroelectrolítico, desnutrición, desajustes metabólicos y sepsis. El apoyo nutricio es parte esencial en el manejo, ya que favorece la función intestinal, inmune, promueve la cicatrización y disminuye el catabolismo. Aunque se ha reconocido la importancia del apoyo nutricio no existen ensayos clínicos sobre su ...

  20. Estudio espectral del ritmo eléctrico básico del intestino delgado para la monitorización no invasiva del marcapasos intestinal

    OpenAIRE

    MORENO VÁZQUEZ, JOSÉ DE JESÚS

    2012-01-01

    El aparato digestivo permite que los alimentos se conviertan en nutrientes y proporcionen al organismo las calorías y los elementos fundamentales para la vida, al mismo tiempo que se expulsan y eliminan los productos residuales de forma adecuada. La motilidad intestinal es muy importante para conseguir la segmentación del quimo y el tránsito intestinal y está determinada por la actividad mioeléctrica de las capas musculares intestinales. Dicha actividad también se le denomina ...

  1. REGULACION DE LA DINAMICA Y METABOLISMO MITOCONDRIAL POR INCRETINA GLP-1 EN CELULAS DE LA LINEA A7R5

    OpenAIRE

    TORRES RIVERA, GLORIA ANDREA

    2014-01-01

    El péptido similar a glucagón-1 (GLP-1) es una incretina secretada por las células intestinales. Su acción clásica es regular la respuesta secretoria de insulina por el páncreas. Sin embargo, recientemente se ha descrito que GLP-1 posee acciones extrapancreáticas muy similares a la insulina, con mecanismos de señalización tejido-específicos. Por sus muchas acciones fisiológicas, y la mayoría relacionadas con los efectos insulinotrópicos de esta incretina, derivados peptidomiméticos de G...

  2. Efecto del ayuno sobre la absorción de Clorhidrato de Metoclopramida : I. Modelo in vitro

    OpenAIRE

    Marano, Claudia G.; Taylor, Susana A.; Volonté, María Guillermina; Reinoso, María Isabel; Lufrano, Pablo

    1988-01-01

    Se estudia el efecto del ayuno sobre la absorción gastrointestinal de clorhidrato de metoclopramida mediante un modelo in vitro que utiliza estómagos y segmentos intestinales de ratas, unas sometidas a un ayuno de 16 horas y otras liberadas a una dieta a voluntad. Se realiza un perfil de velocidad de transferencia de la droga durante un determinado período. Los resultados muestran una mayor velocidad para los intestinos de ratas en ayuno respecto a los provenientes de ratas alimentadas, y un ...

  3. Efecto del ayuno sobre la absorción de Ciprofloxacina : Modelo in vitro

    OpenAIRE

    Volonté, María Guillermina

    1993-01-01

    Se analiza el efecto del ayuno sobre la absorción gastrointestinal de ciprofloxacina mediante la utilización de un modelo in vitro que emplea estómagos y segmentos intestinales proximales aislados de ratas, separadas en dos lotes, uno de ellos sometido a un ayuno de 16 horas y el otro liberado a una dieta de alimento balanceado a voluntad. Los resultados muestran una transferencia intestinal parcial de la droga y una absorción estomacal despreciable, comprobándose que el ayuno no tiene efecto...

  4. Frecuencia de parasitismo intestinal en manipuladores de alimentos de cinco ciudades de Colombia, 2008

    OpenAIRE

    2009-01-01

    El objetivo principal de este estudio fue hallar la frecuencia de parásitos intestinales en manipuladores de alimentos que laboran en restaurantes de comidas diversas para el público, ubicados en cinco ciudades capitales del país, y conocer en estos establecimientos la implementación de las buenas prácticas de manufactura como una estrategia para la disminución de la morbilidad parasitaria y como una herramienta para su prevención. Se visitaron 300 restaurantes donde se encuestaron 905 manipu...

  5. TEMA 15-2015: Beneficios de la colostomía en la calidad de vida del paciente con lesión medular crónica y ventajas de su realización por vía laparoscópica

    OpenAIRE

    Leitón Chaves, Andres; Hu Liang, Huxian; Ramírez Valverde, Jose Miguel

    2015-01-01

    Las investigaciones recientes sugieren que el manejo de los problemas intestinales es una fuente importante de preocupación para los pacientes con lesión medular y puede alterar significativamente la calidad de vida. Los síntomas gastrointestinales más comunes hallados fueron estreñimiento e incontinencia fecal, reportado por 46% y 41%, respectivamente. Distensión abdominal se reportó en un 22% y el dolor gastrointestinal (dolor abdominal, rectal o anal) fue reportado por 33% de los pacientes...

  6. Prevalencia de patologías tropicales y factores de riesgo en la comunidad indígena de bunkwimake, sierra nevada de Santa Marta

    OpenAIRE

    Dib, Juan C.; Luz Adriana Agudelo; Iván Darío Vélez

    2013-01-01

    Las enfermedades tropicales son endémicas en la Sierra Nevada de Santa Marta, sin embargo se carece de información acerca de la distribución de estas enfermedades en las comunidades indígenas que la habitan. Mediante estudios entomológicos y seroepidemiológicos, se estudiaron los factores de riesgo y la prevalencia de enfermedad de Chagas, leishmaniosis, hepatitis B y parasitosis intestinales en la comunidad indígena de Bunkwimake, ubicada en la vertiente norte de la Sierra Nevada. Los result...

  7. Parasitosis intestinal y factores de riesgo en niños de los asentamientos subnormales, Florencia-Caquetá, Colombia / Intestinal parasitism and risk factors among children from the Illegal settlements of Florencia-Caquetá, Colombia

    OpenAIRE

    Tarín A. Lucero-Garzón; Luís A. Álvarez-Motta; Jeison F. Chicue-López; Deyirley López-Zapata; Cristian A. Mendoza-Bergaño

    2015-01-01

    RESUMEN Objetivo: determinar la prevalencia de parásitos intestinales y factores de riesgo en niños de 0-5 años residentes de los asentamientos subnormales del sector conocido como Ciudadela Siglo XXI en Florencia-Caquetá, Colombia. Metodología: estudio descriptivo transversal, se recolectaron 193 muestras fecales de igual número de niños, la presencia de parásitos se evaluó por examen coprológico directo y otro por concentración mediante técnica Ritchie-Frick, se realizó coloración de Kin...

  8. Increased Serum Levels of Epidermal Growth Factor in Children with Autism

    Science.gov (United States)

    Iseri, Elvan; Guney, Esra; Ceylan, Mehmet F.; Yucel, Aysegul; Aral, Arzu; Bodur, Sahin; Sener, Sahnur

    2011-01-01

    The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral…

  9. Linezolid and Rasagiline - A culprit for serotonin syndrome

    Directory of Open Access Journals (Sweden)

    Mohamed Hisham

    2016-01-01

    Full Text Available A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline.

  10. Quando il movimento è malato: la sclerosi laterale amiotrofica

    Directory of Open Access Journals (Sweden)

    Lucio Tremolizzo

    2011-09-01

    Full Text Available La sclerosi laterale amiotrofica (SLA è una malattia neurodegenerativa descritta dal celeberrimo neurologo francese Jean - Martin Charcot (Parigi 1825 - Nièvre 1893 sul finire del 1800. Il quadro è caratterizzato dal coinvolgimento selettivo del primo e del secondo motoneurone, le cellule che, convergendo sul muscolo (l’effettore finale, sono deputate all’espressione del movimento.

  11. Bacteroides isolated from four mammalian hosts lack host specific 16S rRNA gene phylogeny and carbon and nitrogen utilization patterns

    Science.gov (United States)

    Within the distal gut of mammals are trillions of microbes that utilize nutrients from diet, intestinal mucosa, and other gut microbes. One hundred three (103) isolates of B. ovatus, B. thetaiotaomicron, and B. xylanisolvens were recovered from cow, goat, human, and pig fecal enrichments with cellul...

  12. COMPARATIVE ASPECTS OF PLANT-CELL WALL DIGESTION IN INSECTS

    NARCIS (Netherlands)

    PRINS, RA; KREULEN, DA

    1991-01-01

    Although many phytophagous and wood-eating invertibrates form their own cellulases, there is an overwhelming variety of symbioses between plant- and wood-utilising insects and microorganisms. In one type of symbiosis (endosymbiosis), insects (rhinoceros beetle, cockroach, lower termites) host cellul

  13. Anti-Ro and anti-La autoantibodies induce TNF-α production by human salivary gland cells: an in vitro study

    Directory of Open Access Journals (Sweden)

    V. Mitolo

    2011-09-01

    Full Text Available Obiettivo: Lo scopo di questo studio è stato valutare la produzione di TNF-α, induttore della via estrinseca del processo apoptotico, in seguito al trattamento con gli autoanticorpi anti-Ro ed anti-La isolati da pazienti con sindrome di Sjögren primaria in un modello sperimentale rappresentato dalla linea cellulare di ghiandole salivari umane, A- 253. È stata, inoltre, valutata la presenza sulla superficie di tali cellule di recettori specifici per tale induttore, TNFR1 e TNFR2. Materiali e metodi: Gli autoanticorpi anti-La ed anti-Ro sono stati purificati su una colonna cromatografia ad alta affinità. Le metodiche utilizzate per la valutazione della produzione di TNF-α e lo studio dei recettori di superficie sono state immunofluorescenza, RT-PCR e saggi immunoenzimatici. Risultati: I nostri risultati hanno dimostrato che le cellule A-253 esprimono in superficie i recettori TNFR1 e TNFR2 e che gli autoanticorpi anti-Ro e anti-La sono in grado di indurre la produzione di TNF-α nelle stesse cellule. Conclusioni: Il trattamento con gli autoanticorpi anti-Ro ed anti-La induce la produzione di TNF-α in cellule di ghiandole salivari umane e questo potrebbe spiegare la attivazione della via estrinseca della apoptosi.

  14. Alternaria fungal dermatitis in a free-ranging javelina (Pecari tajacu).

    Science.gov (United States)

    Shender, Lisa A; Gerhold, Rick; Sanchez, Susan; Keel, M Kevin

    2011-07-01

    We report a javelina from Pinal County, Arizona, USA, with severe fungal dermatitis and cellulitis. Extreme emaciation and rostral disfiguration, including left-lateral displacement of the nasal planum, justified euthanasia. A pus-filled tract within the rostrum was observed. Histopathology revealed granulomatous inflammation with hyphae morphologically consistent with Alternaria sp. isolated by culture.

  15. Bone scintigraphy for neonatal osteomyelitis: simulation by extravasation of intravenous calcium

    Energy Technology Data Exchange (ETDEWEB)

    Balsam, D.; Goldfarb, C.R.; Stringer, B.; Farruggia, S.

    1980-04-01

    Intravenously administered calcium gluconate has become increasingly popular in the treatment of neonatal tetany. Occasionally, extravasation results in cellulitis, leading to a clinical diagnosis of superimposed osteomyelitis. Osseous scintigraphy, as the accepted modality in the early detection of osteomyelitis, would tend to be used in this circumstance. This case illustrates a false-positive result, probably due to soft-tissue calcification.

  16. Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia

    DEFF Research Database (Denmark)

    Vigano, A.; Ripamonti, M.; Palma, S. De;

    2008-01-01

    High altitude hypoxia is a paraphysiological condition triggering redox status disturbances of cell organization leading, via oxidative stress, to proteins, lipids, and DNA damage. In man, skeletal muscle, after prolonged exposure to hypoxia, undergoes mass reduction and alterations at the cellul......, whereas the mammalian target of rapamycin (mTOR), a marker of protein synthesis, was reduced Udgivelsesdato: 2008/11...

  17. Antimicrobial Prophylaxis in Adults

    OpenAIRE

    Enzler, Mark J.; Berbari, Elie; Osmon, Douglas R.

    2011-01-01

    Antimicrobial prophylaxis is commonly used by clinicians for the prevention of numerous infectious diseases, including herpes simplex infection, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous bacterial peritonitis in patients with cirrhosis, influenza, infective endocarditis, pertussis, and acute necrotizing pancreatitis, as well as infections associated with open fractures, recent prosthetic joint placement...

  18. Mycobacterium fortuitum Infection following Reconstructive Breast Surgery: Differentiation from Classically Described Red Breast Syndrome

    Directory of Open Access Journals (Sweden)

    Orlando J. Cicilioni, Jr, MD, FACS

    2013-10-01

    Conclusions: When presented with possible RBS, surgeons must rule out cellulitis, culture for acid-fast bacilli such as mycobacterium species, and then determine the best course of treatment. Patient counseling regarding potential household sources of infection is warranted to minimize postoperative infection risk.

  19. Strangulated umbilical hernia in a child.

    OpenAIRE

    1983-01-01

    We describe a case of strangulated umbilical hernia in a girl aged 5 years. She presented with an acute inflammatory lesion at the umbilicus which was initially thought to be due to cellulitis with possible abscess formation. Exploration revealed an umbilical hernia containing necrotic greater omentum.

  20. Disseminated Soft Tissue Infection and Sepsis with Stenotrophomonas maltophilia in a Bone Marrow Transplant Patient

    Directory of Open Access Journals (Sweden)

    Jeffrey H Lipton

    1996-01-01

    Full Text Available A 32-year-old female presented with aplastic anemia and subsequently underwent a one-antigen mismatched bone marrow transplant from her brother. She failed to engraft and a second graft was attempted. Protracted neutropenia of three months’ duration despite the use of broad spectrum antibiotics occurred. Stenotrophomonas (Xanthomonas maltophilia metastatic cellulitis developed that did not respond to appropriate antibiotics.

  1. Roseomonas gilardii infection: case report and review.

    Science.gov (United States)

    Shokar, Navkiran K; Shokar, Gurjeet S; Islam, Jamal; Cass, Alvah R

    2002-12-01

    Roseomonas gilardii is a bacterium that has been indicated as a rare cause of human infections. The case of a patient presenting with cellulitis and bacteremia secondary to R. gilardii is described together with the clinical characteristics of infection with this organism obtained from a review of cases previously reported.

  2. Immune ThrombocytoPenia (ITP) secondary to Chronic Lymphoproliferative Disorders (LPDs) | EU Clinical Trials Register [EU Clinical Trials Register

    Lifescience Database Archive (English)

    Full Text Available ome complicanza della malattia linfoproliferativa (linfoma o leucemia linfatica c...do la classificazione WHO del 2008: piccolo linfoma linfocitico/leucemia linfatica cronica, linfoma follicol...are, linfoma della zona marginale, linfoma a cellule del mantello, linfoma linfoplasmacellulare, leucemia a

  3. Emergency War Surgery: Third United States Revision

    Science.gov (United States)

    2004-01-01

    soft tissue infection, such as clostridial gas gangrene or necrotizing fasciitis . Systemic effects such as fever, leukocytosis, unexplained...streptococcal, and clostridial species. These infections include wound abscess, cellulitis, septic arthritis, osteomyelitis, necrotizing fasciitis , and...clostridial infection. Crepitus, radiographic evidence of soft-tissue gas, epidermal blistering, and/or epidermal necrosis are the hallmarks of necrotizing

  4. Journal of Special Operations Medicine. Volume 2, Edition 4, Fall 2002

    Science.gov (United States)

    2002-01-01

    clostridial myonecrosis must encompass other gas-forming infections, including necrotizing fasciitis , streptococ- cal myositis, acute streptococcal...REFERENCES 1. Riseman J, Zamboni W, Curtis A, et al: Hyperbaric oxygen therapy for necrotizing fasciitis reduces mortality and the need for...hemolytic gangrene, crepitant cellulitis, and synergistic necrotizing celluli- tis. The crepitance should be differentiated from other causes of

  5. Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer

    NARCIS (Netherlands)

    Brisset, Jean-Christophe; Hoff, Benjamin A.; Chenevert, Thomas L.; Jacobson, Jon A.; Boes, Jennifer L.; Galban, Stefanie; Rehemtulla, Alnawaz; Johnson, Timothy D.; Pienta, Kenneth J.; Galban, Craig J.; Meyer, Charles R.; Schakel, Timothy; Nicolay, Klaas; Alva, Ajjai S.; Hussain, Maha; Ross, Brian D.; Schakel, Tim

    2015-01-01

    Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellul

  6. Linezolid and Rasagiline - A culprit for serotonin syndrome

    OpenAIRE

    Mohamed Hisham; Mundalipalayam N Sivakumar; Nandakumar, V; S Lakshmikanthcharan

    2016-01-01

    A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline.

  7. Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders

    NARCIS (Netherlands)

    Baker, Darren J.; Wijshake, Tobias; Tchkonia, Tamar; LeBrasseur, Nathan K.; Childs, Bennett G.; van de Sluis, Bart; Kirkland, James L.; van Deursen, Jan M.

    2011-01-01

    Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellul

  8. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

    NARCIS (Netherlands)

    Baker, D.J.; Wijshake, T.; Tchkonia, T.; LeBrasseur, N.K.; Childs, B.G.; Sluis, B. van de; Kirkland, J.L.; Deursen, J.M.A. van

    2011-01-01

    Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellul

  9. Extraintestinal Vibrio infections in Mauritius.

    Science.gov (United States)

    Issack, Mohammad I; Appiah, Deoraz; Rassoul, Ameen; Unuth, Mahesswaree N; Unuth-Lutchun, Nehma

    2008-10-01

    Few extraintestinal Vibrio infections have been reported in the African region. We report 3 cases from Mauritius: one case of Vibrio alginolyticus otitis externa; one case of soft tissue infection caused by non-O1 Vibrio cholerae and Vibrio parahaemolyticus; and one fatal case of non-O1 V. cholerae cellulitis and septicaemia.

  10. 38 CFR 17.272 - Benefits limitations/exclusions.

    Science.gov (United States)

    2010-07-01

    ...) Intraoral abscess when it extends beyond the dental alveolus. (vi) Extraoral abscess. (vii) Cellulitis and... necessary to perform the function of the human lens, lost as a result of intraocular surgery, ocular injury... requiring a prescription, except for insulin and related diabetic testing supplies and syringes....

  11. Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum

    NARCIS (Netherlands)

    Van Der Zee, Maurijn; Benton, Matthew A.; Vazquez-Faci, Tania; Lamers, Gerda E M; Jacobs, Chris G C; Rabouille, Catherine

    2015-01-01

    In insects thefertilized egg undergoes a series of rapid nuclear divisions before the syncytial blastoderm starts to cellularize. Cellularization has been extensively studied in Drosophila melanogaster but its thick columnar blastoderm is unusual among insects.We therefore set out to describe cellul

  12. A non-travel related rash in a traveler

    Directory of Open Access Journals (Sweden)

    Keith A. Sacco

    2017-01-01

    Full Text Available A 45-year-old man was admitted for investigation of a symmetric lower limb rash associated with recurrent fever for two weeks following a hiking trip in Italy and Greece. He was treated for sepsis secondary to lower limb cellulitis with no clinical improvement and subsequently diagnosed with Streptococcus gallolyticus endocarditis mediating an infectious vasculitis.

  13. To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture

    NARCIS (Netherlands)

    Willmann, Charlotte A; Hemeda, Hatim; Pieper, Lisa A; Lenz, Michael; Qin, Jie; Joussen, Sylvia; Sontag, Stephanie; Wanek, Paul; Denecke, Bernd; Schüler, Herdit M; Zenke, Martin; Wagner, Wolfgang

    2013-01-01

    Induced pluripotent stem cells (iPSCs) are usually clonally derived. The selection of fully reprogrammed cells generally involves picking of individual colonies with morphology similar to embryonic stem cells (ESCs). Given that fully reprogrammed cells are highly proliferative and escape from cellul

  14. InterProScan Result: FS918167 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS918167 FS918167_2_ORF1 D5AE1121C885716E PANTHER PTHR15314 RIBONUCLEASE P PROTEIN ...SUBUNIT P20 2.5e-30 T IPR014612 unintegrated Molecular Function: ribonuclease P activity (GO:0004526)|Cellul

  15. Acute lymphangitis in a preschool child: A case report

    Directory of Open Access Journals (Sweden)

    Loh Huai Seng

    2012-12-01

    Full Text Available A 3-year old preschool boy presented with apruritic red streak at the dorsum of his right foot travelingupward from the affected site which was red and swollen.Insect sting was the more likely trigger which had causedthe cellulitis and subsequently the acute lymphangitis.

  16. Contingency Contracting: A Framework for Reform

    Science.gov (United States)

    2010-05-14

    medical sick-call records showed 38 cases that an attending medical official said could be attributed to water, such as skin abscesses, cellulitis ...skin infections , and diarrhea. (Report No. D-2008-060) DCMA inspected the M2 gun parts at the contractor’s facility and inappropriately approved

  17. Endoscopic component separation for ventral hernia causes fewer wound complications compared to open components separation

    DEFF Research Database (Denmark)

    Jensen, Kristian K; Henriksen, Nadia A; Jorgensen, Lars N

    2014-01-01

    -analysis reporting on a total of 163 patients. Patient demography and the rates of mesh repair were comparable between the ECS and OCS patient groups. The incidence of wound complications comprising surgical site infection, skin necrosis, subcutaneous abscess, seroma, skin dehiscence, cellulitis, and fistula...

  18. Caratterizzazione di alterazioni molecolari relative alla patogenesi delle Neoplasie Mieloproliferative Croniche

    OpenAIRE

    Bogani, C

    2009-01-01

    Il primo obiettivo dello studio è stato di chiarire il ruolo svolto dal sistema CXCR4-SDF1 nella abnorme circolazione di cellule CD34+ nei pazienti con PMF. Il secondo obiettivo dello studio è stato di analizzare il coinvolgimento della pathway PI3K/AKT/mTOR nella deregolazione funzionale dei progenitori ematopoietici di pazienti con Policitemia Vera e Mielofibrosi Primaria.

  19. Caracterisation thermique de modules de refroidissement pour la photovoltaique concentree

    Science.gov (United States)

    Collin, Louis-Michel

    Pour rentabiliser la technologie des cellules solaires, une reduction du cout d'exploitation et de fabrication est necessaire. L'utilisation de materiaux photovoltaiques a un impact appreciable sur le prix final par quantite d'energie produite. Une technologie en developpement consiste a concentrer la lumiere sur les cellules solaires afin de reduire cette quantite de materiaux. Or, concentrer la lumiere augmente la temperature de la cellule et diminue ainsi son efficacite. Il faut donc assurer a la cellule un refroidissement efficace. La charge thermique a evacuer de la cellule passe au travers du recepteur, soit la composante soutenant physiquement la cellule. Le recepteur transmet le flux thermique de la cellule a un systeme de refroidissement. L'ensemble recepteur-systeme de refroidissement se nomme module de refroidissement. Habituellement, la surface du recepteur est plus grande que celle de la cellule. La chaleur se propage donc lateralement dans le recepteur au fur et a mesure qu'elle traverse le recepteur. Une telle propagation de la chaleur fournit une plus grande surface effective, reduisant la resistance thermique apparente des interfaces thermiques et du systeme de refroidissement en aval vers le module de refroidissement. Actuellement, aucune installation ni methode ne semble exister afin de caracteriser les performances thermiques des recepteurs. Ce projet traite d'une nouvelle technique de caracterisation pour definir la diffusion thermique du recepteur a l'interieur d'un module de refroidissement. Des indices de performance sont issus de resistances thermiques mesurees experimentalement sur les modules. Une plateforme de caracterisation est realisee afin de mesurer experimentalement les criteres de performance. Cette plateforme injecte un flux thermique controle sur une zone localisee de la surface superieure du recepteur. L'injection de chaleur remplace le flux thermique normalement fourni par la cellule. Un systeme de refroidissement est installe

  20. Oxti-photo-battery: utilization of new oxygenated titanium polymers for the elaboration of thin photoactive films by sol-gel techniques. Realization of photovoltaic cells exempt from photo sensitizer and development of photo batteries. Concerted actions energy (PE1). Final report. July 2004; Oxti-photobatterie: Utilisation de nouveaux polymeres oxygenes du titane pour l'elaboration de films minces photoactifs par des techniques sol-gel. Realisation de cellules photovoltaiques exemptes de photosensibilisateurs et developpement de photobatteries. Action concertee energie (PE1). Rapport final. Juillet 2004

    Energy Technology Data Exchange (ETDEWEB)

    Brohan, L. [Laboratoire de Chimie des Solides, 44 - Nantes (France); Nunzi, J.M. [Angers Univ., Laboratoire des Proprietes Optiques des Materiaux et Applications, 49 - Angers (France)

    2004-07-01

    This coordinated project aims to elaborate new photovoltaic cells realized from a photosensitive titanium gel, called ''TiDMF''. This inorganic polymer, presents interesting optical properties: it takes a bleu color (by reduction of the Ti{sup 4+} in Ti{sup 3+}), after exposition to the day light. This particularity allows the realization of solar cells exempt from photo sensitizer. (A.L.B.)

  1. [Churg-Strauss abdominal manifestation].

    Science.gov (United States)

    Suarez-Moreno, Roberto; Ponce-Pérez, Luis Virgilio; Margain-Paredes, Miguel Angel; Garza-de la Llave, Heriberto; Madrazo-Navarro, Mario; Espinosa-Álvarez, Arturo

    2014-01-01

    Antecedentes: la enfermedad de Churg-Strauss es poco común, idiopática, caracterizada por hipereosinofilia en sangre y tejidos, aunada a vasculitis sistémica en pacientes con antecedentes de asma o rinitis alérgica. Las manifestaciones gastrointestinales del síndrome de Churg Strauss se caracterizan por dolor abdominal, seguido de diarrea y hemorragia en 31-45% de los casos. Caso clínico: paciente masculino con antecedente de asma que acudió a consulta por abdomen agudo con probable apendicitis aguda; durante el protocolo de estudio se diagnosticó síndrome de Churg Strauss, con manifestaciones intestinales. Conclusión: el síndrome de Churg Strauss es una vasculitis poco frecuente que puede manifestarse con síntomas intestinales, como en este caso; es importante tenerlo en mente a la hora de los diagnósticos diferenciales. Existen pocos reportes con este síndrome asociado con abdomen agudo, todos ellos con mal pronóstico.

  2. The origin of cholesterol in chyle demonstrated by nuclear indicator methods; Origines du cholesterol du chyle mises en evidence par la methode des indicateurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Vyas, M

    1962-07-01

    In order to obtain information about the mechanism of the intestinal absorption of cholesterol, rats having a lymphatic abdominal fistula are used. The animals receive either 4-{sup 14}C- cholesterol subcutaneously or orally, or the 1-{sup 14}C acetate. The study of the specific radio-activities of the cholesterol in chyle, in serum, in the lining, and in the intestinal contents makes it possible to define the roles played by the transfer cholesterol from the serum, by the cholesterol synthesised intestinally, and by the absorption cholesterol, in the formations of the lymph and of the chylomicrons. A new theory is proposed for the mechanism of cholesterol absorption. (author) [French] Pour obtenir des renseignements concernant le mecanisme de l'absorption intestinale du cholesterol, on utilise des rats porteurs d'une fistule lymphatique abdominale. Les animaux recoivent soit du cholesterol 4-{sup 14}C par voie sous-cutanee ou par voie orale, soit de l'acetate 1-{sup 14}C. L'etude des radioactivites specifiques du cholesterol du chyle, du serum, de la paroi et du contenu intestinal permet de preciser les roles joues par le cholesterol de transfert d'origine serique, par le cholesterol de synthese intestinale et par le cholesterol d'absorption, dans la formation de la lymphe et des chylomicrons. Une theorie nouvelle concernant le mecanisme de l'absorption du cholesterol est proposee. (auteur)

  3. PRUEBAS DE SENSIBILIDAD FRENTE A AGENTES ANTIMICROBIANOS EN CEPAS DE Brachyspira pilosicoli AISLADAS A PARTIR DE PONEDORAS COMERCIALES EN COLOMBIA

    Directory of Open Access Journals (Sweden)

    DM Álvarez

    2009-01-01

    Full Text Available Las espiroquetas intestinales del género Brachyspira ocasionan enfermedades importantes en porcinos y aves. Se ha evidenciado un problema de incremento en la presentación de cepas resistentes a los antimicrobianos utilizados normalmente para tratar las espiroquetosis intestinales en porcinos, y esto podría ser aplicable a los aislamientos de aves. Hay muy pocos reportes de sensibilidad antimicrobiana in vitro de cepas de Brachyspira spp. aisladas en aves. En este estudio se evaluó la sensibilidad de doce aislamientos de Brachyspira pilosicoli obtenidos de granjas de ponedoras comerciales a los agentes antimicrobianos tiamulina, tilosina y lincomicina, y se estableció la concentración mínima inhibitoria (CMImediante la técnica de dilución en agar. Todas las bacterias analizadas fueron sensibles a tiamulina (CMI ≤0,1 μg/ml y lincomicina (CMI 1 μg/ml y resistentes a tilosina (CMI 5 μg/ml.

  4. L'(E)TABLISSEMENT D'UN MOD(E)LE CELLULAIRE DE L'OLIGONUCL(E)OTIDE MUTANT

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objectif Pour établir un modèle cellulaire de l'oligonucléotide mutant. Méthodes Par rapport la prise du gène de la protéine de fluorescence verte et agrandisse (EGFP), nous induissons une mutation par la technique du point mutant de PCR pour changer du codon de 98ème position du gène egfp GAA au codon d' arrêt TAA , formant le gène egfp-D de mutant, donc on construit deux vecteurs de plasmides : pcDNA3-egfp et pcDNA3-egfp-D. Puis les plasmides sont transférés dans les cellules NIH-3T3 par le calcium de phosphate. Résultats Sous le microscope de fluorescence, on n'a pas vu l'expression de la EGFP dans tous les cellules transférées par l' egfp-D de mutant, et en même temps, les cellules transférées par l'egfp normal peuvent exprimer la EGFP. Ensuite on obtient les cellules stables par le criblage de G418. PCR confirme l'intégration du gène egfp-D dedans le génome ADN des cellules. RT-PCR et Northern blot analysent les gènes egfp et egfp-D peuvent transcrire normalement, il montre les cellules transférées par le gène egfp-D de mutant n'exprimant pas la fluorescence verte est parce que la traduction est terminée en avant. Conclusion Le modèle cellulaire de l'oligonucléotide mutant rapporté par le gène egfp est établi avec succès, ce modèle peut employer en recherche du système réparant thérapeutique via le chimeric ARN /ADN oligonucléotide (RDOs).

  5. Effect of heavy metals and benzene on porphyrin synthesis of human epithelial larynx carcinoma cells (HEp-2); Wirkung von Schwermetallen und Benzol auf die Porphyrinsynthese von Humanen epithelialen Larynxkarzinomzellen (HEp-2)

    Energy Technology Data Exchange (ETDEWEB)

    Tumat, C.; Kath, H.G.; Perlewitz, J.; Manuwald, O. [Institut fuer Umweltmedizin, Erfurt (Germany); Herbarth, O. [UFZ - Umweltforschungszentrum Leipzig-Halle GmbH, Leipzig (Germany). Sektion Expositionsforschung und Epidemiologie

    2001-07-01

    Aim of the investigation was to prepare an environmental epidemiological test to detect the effects of pollutants by a pattern of porphyrin excretion in the urine. The task was to test whether lead, mercury, copper, zinc and benzene in environmentally relevant concentrations influence porphyrin synthesis of cells. The model used was the permanent epithelial larynx carcinoma cell line HEp-2, which was stimulated to synthesize porphyrins by adding {delta}-amino-levulinic acid ({delta}-ALA) in excess. 8- to 4-carboxyporphyrins and protoporphyrin IX were measured both in the cells and in the culture medium by means of high performance liqid cromatography (HPLC). The following pollutant effects were found: lead: extracellular increase of hexacarboxyporphyrin and intracellular decrease of heptacarboxy- and copro-porphyrin; mercury: extracellular decrease of heptacarboxyporphyrin and intracellular increase of coproporphyrin; copper: extracellular decrease of uro-, coproporphyrin and protoporphyrin IX, extracellular increase of heptacarboxyporphyrin and intracellular decrease of uro-, heptacarboxy- and coproporphyrin; zinc: extracellular increase of coproporphyrin; benzene: a tendency to extracellular increase of hexacarboxyporphyrin. The main result is the decrease in the concentrations of porphyrins caused by copper. This result is possibly linked to gastro-intestinal diseases among children due to drinking water from copper water pipes. (orig.) [German] Ziel der Untersuchungen war es, Vorarbeit zu leisten fuer die Entwicklung eines umwelt-epidemiologischen Tests, der es ermoeglicht, geringe Schadstoffwirkungen durch ein Porphyrin-Ausscheidungsmuster im Urin nachzuweisen. In diesem Zusammenhang bestand die Aufgabe zu pruefen, ob Blei, Quecksilber, Kupfer, Zink und Benzol in umweltmedizinisch relevanten Konzentrationen die Porphyrinsythese von Zellen beeinflussen. Als Untersuchungsmodell wurde die permanente humane epitheliale Larynxkarzinomzelllinie HEp-2 genutzt, die

  6. Pelvic Surgical Site Infections in Gynecologic Surgery

    Directory of Open Access Journals (Sweden)

    Mark P. Lachiewicz

    2015-01-01

    Full Text Available The development of surgical site infection (SSI remains the most common complication of gynecologic surgical procedures and results in significant patient morbidity. Gynecologic procedures pose a unique challenge in that potential pathogenic microorganisms from the skin or vagina and endocervix may migrate to operative sites and can result in vaginal cuff cellulitis, pelvic cellulitis, and pelvic abscesses. Multiple host and surgical risk factors have been identified as risks that increase infectious sequelae after pelvic surgery. This paper will review these risk factors as many are modifiable and care should be taken to address such factors in order to decrease the chance of infection. We will also review the definitions, microbiology, pathogenesis, diagnosis, and management of pelvic SSIs after gynecologic surgery.

  7. Cervical celullitis in broiler chickens for Escherichia coli/ Celulite cervical em frangos de corte causada por Escherichia coli

    Directory of Open Access Journals (Sweden)

    Ivens Gomes Guimarães

    2002-05-01

    Full Text Available In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frangos de corte apresentando lesão de celulite na região cervical. Foi realizado o isolamento de E. coli da lesão de celulite e realizado exames histopatológicos que caracterizaram a lesão. Na epiderme foram verificadas lesões ulcerativas, presença de fibrina na derme e infiltração difusa de linfócitos e heterófilos no tecido subcutâneo.

  8. Vasculotoxic snake bite presenting with sepsis, acute renal failure, disseminated intravascular coagulation, and acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Vikram Bhausaheb Vikhe

    2013-01-01

    Full Text Available Vasculotoxic snake bites are well known to cause local complications like necrosis and cellulitis and systemic complications such as coagulopathy, acute renal failure (ARF, and hemolysis. We report a case of young female patient who was bitten by a viper. She developed cellulitis, sepsis, ARF, and Disseminated Intravascular Coagulation. She was treated for the above complications and all her renal and hematological parameters returned to normal on seventh day. After this, on the same day, patient developed Acute Respiratory Distress Syndrome probably due to the direct toxic effect of venom on pulmonary vascular endothelium which has been reported as a late complication of snake venom. With close monitoring and proper management of complications, the patient recovered and walked out of the hospital on the twenty first day without any complications.

  9. Morganella morganii in sinonasal region: A rare case report

    Directory of Open Access Journals (Sweden)

    Haşmet Yazıcı

    2013-09-01

    Full Text Available Morganella morganii is a gram negative pathogen andmay cause potentially lethal disease especially in patientswith underlying or immunosuppressive disease. It is commonlyfound in long-term urinary catheter used and immunesystem deficiency patients as nosocomial disease.Involving other systems such as skin, skeletal systemand central nervous system can be seen too. Sporadicoccurrence is rare and can be seen in any system by variouscauses like AIDS, snake bites and poisoning. In thiscase we present sporadic Morganella morganii infectionon sinonasal region with the presence of sinusitis, sinocutaneousfistula, preseptal cellulitis and hard palate defecton 58 year old male diabetic patient. Microbiologicalassessment from open wound and sinuses were reportedas Morganella morganii. To our knowledge, this is the firstcase of sino-nasal Morganella morganii infection with sino-cutaneous fistula, preseptal cellulitis and maxillofacialbone destruction. J Clin Exp Invest 2013; 4 (3: 383-386Key words: Morganella Morganii, sino-nasal fistula, preseptalcellulitis, bone destruction

  10. Mesure par conductimetrie de la receptivite aux maladies fongiques et du niveau de resistance induite par elicitation. Etude sur 3 modeles experimentaux

    OpenAIRE

    Molot, P.M.; Mas, P.; Pivot, V; Bruneteau, M; Staron, T; Ferriere, H.; Lemaire, J.M.

    1992-01-01

    L’appréciation des dégâts parasitaires, souvent difficile à évaluer, peut être effectuée par des mesures conductimétriques; en effet, les cellules altérées libèrent davantage d’électrolytes que les cellules saines dans le milieu extérieur, dont on mesure la conductance. Cette méthode peut être utilisée dans différents cas, notamment lorsqu’il y a attaque au niveau racinaire. On mesure alors la conductance de l’eau dans laquelle baignent des racines contaminées (piment - Phytophthora capsici, ...

  11. Radionuclide imaging in the evaluation of osteomyelitis and septic arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, E.E.; Haynie, T.P.; Podoloff, D.A.; Lowry, P.A.; Harle, T.S. (Univ. of Texas M.D. Anderson Hospital, Houston (USA))

    1989-01-01

    Despite controversy over its exact role, radionuclide imaging plays an important role in the evaluation of patients suspected of having osteomyelitis. The differentiation between osteomyelitis and cellulitis is best accomplished by using a three-phase technique using Tc-99m methylene diphosphonate (MDP). Frequently, it is necessary to obtain multiple projections and magnification views to adequately assess suspected areas. It is recommended that a Ga-67 or In-111 leukocyte scan be performed in those cases where osteomyelitis is strongly suspected clinically and the routine bone scan is equivocal or normal. Repeated bone scan after 48 to 72 h may demonstrate increased radioactivity in the case of early osteomyelitis with the initial photon-deficient lesion. In-111 leukocyte imaging is useful for the evaluation of suspected osteomyelitis complicating recent fracture or operation, but must be used in conjunction with clinical and radiographic correlation. The recognition of certain imaging patterns appears helpful to separate osteomyelitis from septic arthritis or cellulitis. 83 references.

  12. Orbital abscess secondary to acute dacryocystitis: case report Abscesso orbitário secundário à dacriocistite aguda: relato de caso

    Directory of Open Access Journals (Sweden)

    Marcia Clivati Martins

    2008-08-01

    Full Text Available Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao conteúdo orbitário resultando em celulite orbitária. Apresentamos um caso de abscesso orbitário intraconal secundário à dacriocistite aguda e uma revisão de literatura de celulite orbitária causada por infecção aguda do saco lacrimal.

  13. Proteomica degli exosomi urinari per la ricerca di biomarcatori nella nefropatia diabetica e nelle tubulopatie ereditarie

    OpenAIRE

    Corbetta,

    2015-01-01

    Le urine costituiscono il fluido biologico di elezione nella ricerca di biomarcatori per le patologie renali in quanto possono essere raccolte in modo semplice e non invasivo; una strategia per la semplificazione del proteoma urinario è rappresentata dall’isolamento degli exosomi urinari (UE), nanovescicole di membrana (30-100 nm) rilasciate dalle cellule epiteliali nello spazio urinario. In questo lavoro abbiamo focalizzato l’attenzione sulla nefropatia diabetica (DN), una comune complicazio...

  14. Green House Gas Control and Agricultural Biomass for Sustainable Animal Agriculture in Developing Countries

    OpenAIRE

    Takahashi, J.

    2010-01-01

    Important green house gases (GHG) attributed to animal agriculture are methane (CH4) and nitrous oxide (N2O), though carbon dioxide (CO2) contributes almost half of total greenhouse effect. Rumen CH4 production in an enteric fermentation can be accounted as the biggest anthropogenic source. Some of prebiotics and probiotics have been innovated to mitigate rumen CH4 emission. The possible use of agricultural biomass consisted of non-edible parts of crop plants such as cellulose and hemi cellul...

  15. The Cubooctahedron Shape—A Suboptimal Cell Shape for 3—Dimensional Cellular System

    Institute of Scientific and Technical Information of China (English)

    ChaGuangming; LiZhengmao; 等

    1995-01-01

    This paper shows a celluler concept for three-dimensional(3-D)case.A new concept of base station lattice(BSL)and co-channel reuse lattice(CCRL)is proposed.A new method of se-lecting the cell shape for 3-D,sphere covering,is explored.From the comparision between the cu-bic cell and the body-centered-cubic(BCC)cell,the cubooctahedron shape -BCC cell is the most e-conomic one.

  16. Cost Effectiveness Analysis of Hygiene-Based Strategies Aimed Toward Prevention of SSTI and MRSA-Associated SSTI Among U.S. Active Duty Army Trainees

    Science.gov (United States)

    2015-03-25

    resistance to oxacillin). The final multivariate negative binomial regression model showed clinical outcomes (microbiology and syndrome ); initial care (MRSA...clinical care (MRSA coverage); syndrome (abscess-cellulitis-like diagnosis); and microbiology (clinical culture). Variable selection into the model was...Services Inc.) 20:161-7 148. Mott PJ, Sisk BW, Arbogast JW, Ferrazzano-Yaussy C, Bondi CA, Sheehan JJ. 2007. Alcohol-based instant hand sanitizer use in

  17. Sequential evolution of bacterial morphology by co-option of a developmental regulator

    OpenAIRE

    Jiang, Chao; Brown, Pamela J.B.; Ducret, Adrien; Brun, Yves V

    2014-01-01

    What mechanisms underlie the transitions responsible for the diverse shapes observed in the living world? While bacteria display a myriad of morphologies 1 , the mechanisms responsible for the evolution of bacterial cell shape are not understood. We investigated morphological diversity in a group of bacteria that synthesize an appendage-like extension of the cell envelope called the stalk 2,3 . The location and number of stalks varies among species, as exemplified by three distinct sub-cellul...

  18. The Effect of Formaldehyde Fixation on RNA: Optimization of Formaldehyde Adduct Removal

    OpenAIRE

    2011-01-01

    Formalin-fixed, paraffin-embedded tissues generally provide low yields of extractable RNA that exhibit both covalent modification of nucleic acid bases and strand cleavage. This frustrates efforts to perform retrospective analyses of gene expression using archival tissue specimens. A variety of conditions have been reported to demodify formaldehyde-fixed RNA in different model systems. We studied the reversal of formaldehyde fixation of RNA using a 50 base RNA oligonucleotide and total cellul...

  19. MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma

    Institute of Scientific and Technical Information of China (English)

    Cameron; M; Smith; David; I; Watson; Michael; Z; Michael; Damian; J; Hussey

    2010-01-01

    Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellul...

  20. Localizzazione della topoisomerasi IB sui telomeri di S. cerevisiae e ruolo della sua attività catalitica sulle modificazioni istoniche

    OpenAIRE

    Russo, Alessandra

    2007-01-01

    Il superavvolgimento del DNA nelle cellule, regolato dalle DNA Topoisomerasi, influenza molti processi biologici, quali la trascrizione, la replicazione, la ricombinazione ed il rimodellamento della cromatina. La DNA Topoisomerasi IB eucariotica, (Top1), è un enzima efficiente nella rimozione dei superavvolgimenti del DNA in vitro e la sua principale funzione cellulare è la rimozione dei superavvolgimenti positivi e negativi generati durante la trascrizione e la replicazione. ...