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Sample records for cellule epitheliale intestinale

  1. Cellulitis

    Science.gov (United States)

    ... in the skin. Cellulitis is sometimes accompanied by fever, chills, and general fatigue. If the infection is left ... Cellulitis may be accompanied by swollen lymph nodes, fever, chills, and fatigue. Self-Care Guidelines If you think ...

  2. M(E)CANISMES MOL(E)CULAIRES IMPLIQU(E)S DANS L'ALT(E)RATION DU PH(E)NOTYPE DES CELLULES (E)PITHELIAL(E)S TUBULAIRES PAR LES CALPA(I)NES EXTRACELLULAIRES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wen-hui; Joelle Perez; Laurent Baud

    2008-01-01

    Objectif Rechercher les mécanismes moléculaires par lesquels des calpaines extracellulaires af-fectent l'adhérence et la mobilité des cellules épithéliales HK-2 dérivées du tubule proximal humain. Méthodes Western blot pour détecter le clivage des chaines α des intégrines; dosage radioimmunologique pour mesurer l' AMP cyclique intracellulaire; fluorescence-activated cell sorting (FACS) pour tester l' apoptose cellulaire. La morpholo-gie des cellules HK-2 a été observée et photographiée. Résultats (1) L ' exposition des cellules HK-2 à la calpaine μ n'a pas entrainé de clivage des chaines o3 et αV des intégrines; (2)l' exposition des cellules HK-2 à la calpaine μ entrainait une augmentation progressive de l' accumulation intracellulaire d' AMP cyclique (P<0.05) qui était associée une résistance cellulaire à l'apoptose(P <0. 05 ) ; (3)l'addition d'un inhibiteur pharmacologique de la protéine kinase A(PKA) prévenait totalement les modifications d'adhérence et de mobilité cellulaires induites par calpaine μ Conclusion Les calpaines externalisées peuvent modifier l' adherence et la mobilité cellulaires via un mécanisme qui implique l'accumulation d' AMP cyclique et l' activation de la PKA. Par ces mécanismes, les calpaines externalisées pourraient jouer un role dans l'induction de la réparation au cours de l'insuffucance rénale aiguё.

  3. Effects of the ionising radiations on the structure and the function of the intestinal epithelial cell; Effets des rayonnements ionisants sur la structure et la fonction de la cellule epitheliale intestinale

    Energy Technology Data Exchange (ETDEWEB)

    Haton, C

    2005-06-15

    The intestinal mucosa is a particularly radio-sensitive tissue and damage may occur following either accidental or therapeutic exposure. the deleterious actions of ionizing radiation are linked to the formation of sometimes overwhelming quantities of reactive oxygen species (R.O.S.). Production of R.O.S. is both direct and indirect from the secondary effects of irradiation. A better comprehension of the underlying mechanisms of injury will lead to more adapted therapeutic approaches to limit the harmful effects of irradiation. The homeostasis of the intestinal epithelium is regulated by three factors: proliferation, apoptosis and differentiation. these three factors were studied using the cell model, HT29, in order to analyze modulations of this balance after irradiation. our results, in agreement with other data, showed the establishment of mitotic delay. This arrest of proliferation was followed by apoptosis to be the major mechanism leading to cell death in this model. thus, for the first time, we have shown that irradiated intestinal epithelial cells preserve their capacity to differentiate. This indicates, although indirectly, that intestinal cells have and preserve an intrinsic capacity restore a functional epithelium. R.O.S. are considered as intermediates between the physical nature of radiations and biological responses. It seems essential to understand anti-oxidant mechanisms used by the cell for defence against the deleterious effects of R.O.S post exposure. This study of several anti-oxidant defence mechanisms of intestinal mucosa, was carried out in vivo in the mouse at different times following abdominal irradiation. We observed an early mitochondrial response in the hours following irradiation revealing this organelle as a particular target. We demonstrated a strong alteration of anti-oxidant capacity as revealed by a decrease in S.O.D.s, catalase and an increase of the G.P.X.s and M.T.s. A part of these modifications appeared to depend on an irradiation-induced inflammatory response. Finally, we showed that the loss of catalase is linked to the onset of structural damage to the mucosa. All of these results orient therapeutic strategies towards inducing the proliferation of crypt cells, rather than an inhibition of apoptosis, since the epithelial cells retain differentiation capacity and so production of functional cells. (aut0009h.

  4. Oncologie gastro-intestinale

    OpenAIRE

    Coucke, Philippe; FREI; FELLEY; FRENZER

    1999-01-01

    Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant chirurgiens, endoscopeurs, oncologues et radio-oncologues s'impose avec encore plus de fermeté, pour tous les cancers digestifs. Les patients devraient autant que possible être inclus dans des protocoles d'études bien conduits et bénéficier d'une chirurgie oncologique optimale.

  5. Caratterizzazione di batteri pigmentati e studio degli effetti di molecole batteriche e vegetali su cellule umane

    OpenAIRE

    Manzo, Nicola

    2013-01-01

    Il lavoro svolto durante questi tre anni di Dottorato è raccolto in questa Tesi ed è suddiviso in quattro capitoli distinti. Due capitoli sono dedicati alla caratterizzazione di bacilli produttori di carotenoidi, uno all'interazione tra il batterio lattico Lactobacillus gasseri e cellule dell'epitelio intestinale umano ed uno agli effetti di un estratto della pianta Aloe arborescens su diverse linee cellulari umane. Tali argomenti, anche se apparentemente indipendenti, sono invece strettam...

  6. Preseptal and Orbital Cellulitis

    OpenAIRE

    Emine Akçay; Gamze Dereli Can; Nurullah Çağıl

    2014-01-01

    Preseptal cellulitis (PC) is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC) is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites) or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epid...

  7. Cellulitis: diagnosis and management.

    Science.gov (United States)

    Bailey, Elizabeth; Kroshinsky, Daniela

    2011-01-01

    Cellulitis is an acute infection of the dermal and subcutaneous layers of the skin, often occurring after a local skin trauma. It is a common diagnosis in both inpatient and outpatient dermatology, as well as in the primary care setting. Cellulitis classically presents with erythema, swelling, warmth, and tenderness over the affected area. There are many other dermatologic diseases, which can present with similar findings, highlighting the need to consider a broad differential diagnosis. Some of the most common mimics of cellulitis include venous stasis dermatitis, contact dermatitis, deep vein thrombosis, and panniculitis. History, local characteristics of the affected area, systemic signs, laboratory tests, and, in some cases, skin biopsy can be helpful in confirming the correct diagnosis. Most patients can be treated as an outpatient with oral antibiotics, with dicloxacillin or cephalexin being the oral therapy of choice when methicillin-resistant Staphylococcus aureus is not a concern. PMID:21410612

  8. [Eosinophilic cellulitis (Wells' syndrome)].

    Science.gov (United States)

    Cerri, D; Carabelli, A; Bertani, E; Portaluppi, F; Novi, C; Gianotti, R; Gelmetti, C

    1990-09-01

    The Authors report a case of eosinophilic cellulitis (Wells' syndrome). The patient was a 61 year old woman, diabetic, with a cardio-respiratory insufficiency and a maniaco-depressive psycosis. She presented, on the upper arms and trunk, a cutaneous eruption of erythematous-urticarial plaques, that histopathologically were characterized by a dermic leukocyte population, with a prevalence of eosinophils, distributed in the perivascular site. Laboratory tests revealed eosinophilia and circulating immune complexes. The etiopathogenesis of the disease is discussed as is the possible role of immune complexes in eosinophilic cellulitis. PMID:2079351

  9. Preseptal and orbital cellulitis

    Directory of Open Access Journals (Sweden)

    Emine Akçay

    2014-09-01

    Full Text Available Preseptal cellulitis (PC is defined as an inflammation of the eyelid and surrounding skin, whereas orbital cellulitis (OC is an inflammation of the posterior septum of the eyelid affecting the orbit and its contents. Periorbital tissues may become infected as a result of trauma (including insect bites or primary bacteremia. Orbital cellulitis generally occurs as a complication of sinusitis. The most commonly isolated organisms are Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, Haempphilus influenzae, Moraxella catarrhalis and S. pyogenes. The method for the diagnosis of OS and PS is computed tomography. Using effective antibiotics is a mainstay for the treatment of PC and OC. There is an agreement that surgical drainage should be performed in cases of complete ophthalmoplegia or significant visual impairment or large abscesses formation. This infections are also at a greater risk of acute visual loss, cavernous sinus thrombosis, meningitis, cerebritis, endophthalmitis, and brain abscess in children. Early diagnosis and appropriate treatment are crucial to control the infection. Diagnosis, treatment, management and complications of PC and OC are summarized in this manuscript. J MicrobiolInfect Dis 2014; 4(3: 123-127

  10. Les complications gastro-intestinales du diabete

    OpenAIRE

    Belaiche, Jacques; GAST, Pierrette; Delwaide, Jean; Etienne, Marie-Thérèse

    1989-01-01

    Les complications gastro-intestinales du diabète peuvent toucher la totalité du tube digestif. Elles sont fréquentes et compliquent habituellement un diabète ancien et insulinodépendant. Elles sont souvent latentes, mises en évidence par des méthodes isotopiques ou manométriques, parfois invalidantes comme la gastroparésie, la diarrhée et l'incontinence fécale. L'atteinte digestive s'associe toujours à une atteinte nerveuse périphérique et fait partie des manifestations neurovégétatives du di...

  11. Odontogenic Facial Cellulitis

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    Yordany Boza Mejias

    2012-11-01

    Full Text Available Background: odontogenic facial cellulitis is an acute inflammatory process manifested in very different ways, with a variable scale in clinical presentation ranging from harmless well defined processes, to diffuse and progressive that may develop complications leading the patient to a critical condition, even risking their lives. Objective: To characterize the behavior of odontogenic facial cellulitis. Methods: A descriptive case series study was conducted at the dental clinic of Aguada de Pasajeros, Cienfuegos, from September 2010 to March 2011. It included 56 patients who met the inclusion criteria. Variables analyzed included: sex, age, teeth and regions affected, causes of cellulite and prescribed treatment. Results: no sex predilection was observed, lower molars and submandibular anatomical region were the most affected (50% and 30 4% respectively being tooth decay the main cause for this condition (51, 7%. The opening access was not performed to all the patients in the emergency service. The causal tooth extraction was not commonly done early, according to the prescribed antibiotic group. Thermotherapy with warm fomentation and saline mouthwash was the most prescribed and the most widely used group of antibiotics was the penicillin. Conclusions: dental caries were the major cause of odontogenic cellulite. There are still difficulties with the implementation of opening access.

  12. Understanding pediatric bacterial preseptal and orbital cellulitis

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    Gonzalez Mithra

    2010-01-01

    Full Text Available Pediatric preseptal and orbital cellulitis are infectious disorders that result in periorbital inflammation. Preseptal cellulitis is often associated with breaches in the skin barrier whereas orbital cellulitis is commonly associated with paranasal sinusitis. Orbital cellulitis may be associated with subperiosteal abscess. It is important to distinguish between preseptal from orbital cellulitis. Clinical examination and diagnostic imaging are useful in determining appropriate management. Patients are usually treated with broad spectrum antibiotics and surgery when indicated.

  13. Evaluation of Pediatric Patients with Orbital and Preseptal Cellulitis

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    Eren Cagan

    2015-06-01

    Conclusion: Preseptal cellulitis is more frequently observed than orbital cellulitis. The most important predisposing factor for orbital cellulitis is sinusitis. Patients with preseptal cellulitis suspected clinically may be diagnosed with orbital cellulitis radiologically. As a result radiological imaging of preseptal cellulitis patients should be considered. [Cukurova Med J 2015; 40(2.000: 267-274

  14. Assessment and management of orbital cellulitis.

    Science.gov (United States)

    Amin, Nikul; Syed, Irfan; Osborne, Sarah

    2016-04-01

    Orbital cellulitis is a medical emergency requiring multidisciplinary team involvement. Early diagnosis and intervention is imperative to avoid serious complications. This article provides an evidence-based approach to the assessment and management of patients with orbital cellulitis. PMID:27071427

  15. Cellulitis

    Science.gov (United States)

    ... Eye Drops Lazy eye (defined) Pink eye (defined) Retinopathy of Prematurity Strabismus Stye (defined) Vision Screening Vision Screening Recommendations ... Eye Drops Lazy eye (defined) Pink eye (defined) Retinopathy of Prematurity Strabismus Stye (defined) Vision Screening Vision Screening Recommendations ...

  16. Cellulitis Due to Salmonella infantis.

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    Satish R Patil

    2013-01-01

    Full Text Available Bacteria of the genus Salmonella are highly adapted for the growth in both humans and animals and cause a wide spectrum of disease. The growth of Serotypes S. typhi and S. paratyphi is restricted to human hosts, in whom these organisms cause enteric (typhoid fever. The remaining Serotypes (non typhoidal Salmonella or NTS can colonize the gastrointestinal tracts of the broad range of animals, including mammals, reptiles, birds and insects. The usual clinical presentation of non-typhoidal salmonellae (NTS infection is self limited gastroenteritis; however bacteremia and focal extra intestinal infection may occur. However salmonella localization to the skin presenting as cutaneous ulceration is regarded as a rare event. Rates of morbidity and mortality associated with NTS are highest among the elderly, infants, and immunocompromised individuals, including those with hemoglobinopathies, HIV infection, or infections that cause blockade of the reticuloendothelial system. We isolated S.infantis in 50 years old man with left leg cellulitis. The serotype was confirmed at Central Research Institute, Kasauli.

  17. Cellule Staminali di Glioblastoma: Terapia Oncolitica con Vettori Erpetici Ingegnerizzati

    OpenAIRE

    Sgubin, Donatella

    2014-01-01

    Il Glioblastoma (GBM), nonostante i migliori standard terapeutici, rimane una patologia a prognosi infausta. L’ipotesi delle Glioma Stem-like Cells (GSCs) prevede che, nella massa tumorale, sia presente una popolazione di cellule resistenti alla chemio e radioterapia e che tali cellule siano quindi le possibili responsabili della recidiva di malattia. Le GSCs, che possiedono caratteristiche comuni alle cellule staminali fisiologicamente presenti nel cervello adulto, sono cellule a lenta cresc...

  18. Cellulitis of the lower limbs: incidence, diagnosis and management

    OpenAIRE

    Atkin, Leanne

    2016-01-01

    Cellulitis is a common clinical condition that is often inaccurately diagnosed. Risk factors for the development of cellulitis include obesity, lymphoedema and lower limb ulceration. It is important to accurately diagnose and effectively treat cellulitis in order to provide cost effective care and reduce patient suffering. This article will deliver an overview on the burden of cellulitis, provide information that will aid accurate diagnosis and summarise current treatment options.

  19. Modulazione fisiologica della permeabilità intestinale e assorbimento di molecole idrofiliche

    OpenAIRE

    De Leo, Luigina

    1983-01-01

    La permeabilità intestinale è regolata dalle tight junctions (TJ) che costituiscono la barriera gastrointestinale e che sono soggette a regolazione fisiologica. Dati di letteratura dimostrano che digiuno e malnutrizione agiscono su tale barriera alterando la morfologia dell’epitelio intestinale e aumentando il movimento degli ioni e delle grandi molecole attraverso la via paracellulare. Partendo da queste osservazioni abbiamo ipotizzato che il digiuno potesse avere un ruolo nella modulazione ...

  20. Il controllo epigenetico di geni oncosoppressori nelle cellule staminali neuronali normali e di medulloblastoma

    OpenAIRE

    Begalli, Federica

    2013-01-01

    Le cellule staminali cerebellari normali fanno parte della grande famiglia delle cellule staminali somatiche, deputate a sostituire le cellule che muoiono per omeostasi fisiologica del tessuto o per un danno. Tali cellule mantengono alcune delle caratteristiche versatili delle cellule staminali embrionali. In particolare sono dotate della capacità di auto-rinnovamento indefinito e di multipotenza, difatti sono in grado di differenziare in più linee cellulari. Le cellule staminali neuronali ...

  1. Cellulitis in a Red Kandhari Bull : A Case Report

    Directory of Open Access Journals (Sweden)

    M M Pathan

    2012-06-01

    Full Text Available A case of cellulitis caused by mixed infection of Staphylococcus spp. and Corynebacterium spp in a Red Kandhari bull leading to death of animal was autopsied at the department. It is being a case of cellulitis in a Red Kandhari bull and placed on record. [Vet. World 2012; 5(3.000: 183-184

  2. Sweet's syndrome associated with cellulitis - a challenging diagnosis*

    OpenAIRE

    Resende, C; Santos, R.; T. Pereira; Brito, C.

    2016-01-01

    Sweet's syndrome is a neutrophilic dermatosis with worldwide distribution that has been associated with inflammatory autoimmune diseases, infections, malignancies, drugs, and pregnancy. The disease is idiopathic in up to 50% of patients. A 64-year-old woman, diagnosed with right limb cellulitis (4 days of evolution), was seen at our department, due to persistent cellulitis and progressive appearance of painful nodules and plaques in both shins and the right forearm (2 days of evolution). Take...

  3. Facial cellulitis revealing choreo-acanthocytosis: a case report

    OpenAIRE

    Samia, Younes; Yosra, Cherif; Foued, Bellazreg; Mouna, Aissi; Olfa, Berriche; Jihed, Souissi; Hammadi, Braham; Mahbouba, Frih-Ayed; Amel, Letaief; Habib, Sfar Mohamed

    2014-01-01

    We report a 62 year-old-man with facial cellulitis revealing choreo-acanthocytosis (ChAc). He showed chorea that started 20 years ago. The orofacial dyskinisia with tongue and cheek biting resulted in facial cellulitis. The peripheral blood smear revealed acanthocytosis of 25%. The overall of chorea, orofacial dyskinetic disorder, peripheral neuropathy, disturbed behavior, acanthocytosis and the atrophy of caudate nuclei was suggestive of a diagnosis of ChAc. To our knowledge no similar cases...

  4. Effects of lymphatic drainage on cellulitis assessed by magnetic resonance

    OpenAIRE

    Patrícia Froes Meyer; Nara Mendes Martins; Flávia Mendes Martins; Rosimary Araújo Monteiro; Karla Morganna Pereira Pinto de Mendonça

    2008-01-01

    The aim of this study was to assess the use of magnetic resonance as a new method for evaluating the manual lymphatic drainage technique in treating cellulitis. Cellulitis is one of the main esthetic problems that lead women toward seeking guidance and specific treatments. There are various therapeutic approaches, owing to the multi-factorial nature of its pathogen, although the effectiveness of most of these has not been definitively proven, given that the assessment methods used are mostly ...

  5. Ambient Ozone and Emergency Department Visits for Cellulitis

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    Mieczysław Szyszkowicz

    2010-11-01

    Full Text Available Objectives were to assess and estimate an association between exposure to ground-level ozone and emergency department (ED visits for cellulitis. All ED visits for cellulitis in Edmonton, Canada, in the period April 1992–March 2002 (N = 69,547 were examined. Case-crossover design was applied to estimate odds ratio (OR, and 95% confidence interval per one interquartile range (IQR increase in ozone concentration (IQR = 14.0 ppb. Delay of ED visit relating to exposure was probed using 0- to 5-day exposure lags. For all patients in the all months (January–December and lags 0 to 2 days, OR = 1.05 (1.02, 1.07. For male patients during the cold months (October-March: OR = 1.05 (1.02, 1.09 for lags 0 and 2 and OR = 1.06 (1.02, 1.10 for lag 3. For female patients in the warm months (April-September: OR = 1.12 (1.06, 1.18 for lags 1 and 2. Cellulitis developing on uncovered (more exposed skin was analyzed separately, observed effects being stronger. Cellulitis may be associated with exposure to ambient ground level ozone; the exposure may facilitate cellulitis infection and aggravate acute symptoms.

  6. Parasitosis intestinales y factores ambientales en una población rural de Argentina, 2002-2003

    OpenAIRE

    Basualdo Farjat, Juan Ángel; Córdoba, María Alejandra; De Luca, María Marta; Ciarmela, María Laura; Pezzani, Betina Cecilia; Grenovero, M. S.; Minvielle, Marta Cecilia

    2007-01-01

    Hemos evaluado la prevalencia de parásitos intestinales en 504 personas y el grado de asociación entre las variables ambientales y los parásitos intestinales hallados en la población, el suelo y el agua de una zona rural de Argentina durante 2002-2003. Se utilizó una encuesta estructurada para relevar las variables ambientales y se examinaron muestras fecales humanas, de agua y de suelo. La prevalencia parasitaria fue de 45,4%. Los protozoos prevalentes fueron Blastocystis hominis (27,2%) y G...

  7. Epidemiological characteristics of lower extremity cellulitis after a typhoon flood.

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    Pei-Chen Lin

    Full Text Available OBJECTIVE: The flood after a typhoon may lead to increase in patients with cellulitis of lower limbs. However, the microbiological features of these cases are rarely reported. We conducted a study of patients with lower extremity cellulitis after a typhoon followed in southern Taiwan to study the risk factors of cellulitis and the bacteriological features of the patients. METHODS: We reviewed all the medical records of cellulitis at emergency departments of two teaching hospitals in southern Taiwan 30 days before and after the landing of Typhoon Morakot and collected data on the demographic and bacteriological characteristics. In addition, we evaluated the relationship between the daily number of patients and the rainfall in the Tainan area. RESULTS: The number of cellulitis patients increased from 183 to 344 during the 30-day period after the typhoon. The number peaked in the third and fourth days and lasted for 3 weeks. The proportion of patients with water immersion of the affected limb was higher after the typhoon (6% vs. 37%, odds ratio [OR]: 9.0, 95% Confidence interval [CI]: 4.7-17.2. We found cultures from the infected limbs with immersion had more polymicrobial (73% vs. 26%, OR: 7.8, 95% CI: 3.2-19.2 and Gram-negative bacilli infection (86% vs. 34%, OR: 11.8, 95% CI: 4.1-34.5. CONCLUSIONS: Flood arose from Typhoon Morakot caused increases in cellulitis patients, which lasted for 3 weeks. Antibiotic treatment that were effective to both Gram-positive cocci and Gram-negative bacilli are recommended for patients with limbs emerged in the water.

  8. Orbital cellulitis following silicone-sponge scleral buckles

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    Nemet AY

    2013-10-01

    Full Text Available Arie Y Nemet, Joseph R Ferencz, Ori Segal, Amit Meshi Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel Background: Acute or chronic infection of the scleral explant is rare. We report seven cases of scleral explant infections that caused orbital cellulitis. Materials and methods: This was a retrospective chart review of oculoplastics at oculoplastics and vitreo-retinal units in a secondary referral hospital. All subjects had orbital cellulitis secondary to scleral buckle in the range of January 1990 to March 2010. Demographics, imaging studies, and pathology specimens were reviewed. Results: A total of 841 silicone-sponge scleral buckle implants for rhegmatogenous retinal detachment were performed. Forty were extracted (4.75%; annual rate of 1.9 cases. Seven (0.83% had orbital cellulitis. The mean time from implantation to presentation was 5.7 years. There was bacterial growth in all specimens, with Staphylococcus aureus in four. Conclusions: Patients who are operated on with silicone-sponge scleral buckling for rhegmatogenous retinal detachment sometimes require removal of the implant because of infection. However, the infection rate is low. Patients should be followed in the long term for possible complications. Keywords: scleral explant infection, scleral buckle, orbital cellulitis, rhegmatogenous retinal detachment

  9. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

    OpenAIRE

    Juan Carlos Fernández Méndez; José Andrés Pérez Vidal; Berta Fernández Méndez

    2010-01-01

    En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mo...

  10. Prevalencia de parasitosis intestinales en unidades educativas de Ciudad Bolívar, Venezuela

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    José Antonio Nastasi Miranda

    2015-07-01

    Full Text Available Introducción: Las parasitosis intestinales a nivel mundial son un problema de salud pública que afecta a los países en las zonas tropicales. Un grupo muy vulnerable a padecer este tipo de infección son los niños. El objetivo de la presente investigación fue determinar la prevalencia general de parásitos intestinales en las Unidades Educativas de Ciudad Bolívar, entre los años 2009 - 2013. Materiales y Métodos: Fueron obtenidos los trabajos de grado sobre el tema del Departamento de Parasitología y Microbiología y así se recolectaron datos sobre edad, sexo, tipo de parasito, especies y asociaciones parasitarias y poder calcular así dicha prevalencia general. Resultados: Se encontró una prevalencia general de 63,1% sin predilección por la edad o sexo. Los tipos de parásitos más prevalentes fueron los protozoarios con 83,5%. Las especies más prevalentes fueron Blastocystis spp con 39,7%, Entamoeba coli con 15,3%, y Giardia intestinalis con 13,4%. Las asociaciones parasitarias más frecuentes Blastocystis spp con Endolimax nana (21,1% y Blastocystis spp con Entamoeba coli. (7,4%. Discusión: Los resultados de este estudio guardan relación con estudios realizados a nivel nacional como internacional, con respecto a las prevalencias de parasitosis, el predominio de protozoarios sobre helmintos en los últimos años, y la indistinción de la infección parasitaria con respecto al género. Conclusiones: La prevalencia aquí estudiada a manera general es alta, se recomienda seguir haciendo este tipo de estudios en escuelas para denotar el impacto de estas infecciones en niños y la consecuencia que esto conlleva.  Cómo citar este artículo: Nastasi JA. Prevalencia de parasitosis intestinales en unidades educativas de Ciudad Bolívar, Venezuela. Rev Cuid. 2015; 6(2:1077-84. http://dx.doi.org/10.15649/cuidarte.v6i2.181

  11. Acetaminophen-induced cellulitis-like fixed drug eruption

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    Neila Fathallah; Chaker Ben Salem; Raoudha Slim; Lobna Boussofara; Najet Ghariani; Kamel Bouraoui

    2011-01-01

    Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption ...

  12. Pseudomonas aeruginosa bacteremia secondary to acute right leg cellulitis

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    Abdul Wahab, Asrul; Rahman, M.M.

    2013-01-01

    Pseudomonas aeruginosa is a gram-negative bacillus that causes wide spectrum clinical infections. However, it is most frequently associated with hospital-acquired infection. In this case a 58-year-old male with underlying hypertension and dyslipidaemia was admitted for acute right leg cellulitis. Pseudomonas aeruginosa was identified from the case, though it was not a usual suspected organism. It might be due to community-acquired infection.

  13. Posttraumatic Fat Necrosis Presented as Cellulitis of the Leg

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    Einat Haikin Herzberger

    2012-01-01

    Full Text Available Cellulitis, a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin, is a common lesion in children, usually responsive to systemic antibiotic therapy. However, an unusual course of healing or some nontypical features should call the treating physician to consider and investigate for other diagnoses that might prevent unnecessary treatment and alleviate parental stress. We present a case of posttraumatic fat necrosis, demonstrating some pitfalls in the process of diagnosis.

  14. Group a streptococcal cellulitis in the early puerperium

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    Nikolić Branka; Mitrović Ana; Dragojević-Dikić Svetlana; Rakić Snežana; Cakić Zlatica; Saranović Milena; Sikimić Milan

    2011-01-01

    Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS) are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerp...

  15. Capacità immunomodulatrice delle cellule staminali mesenchimali di cavallo da midollo osseo: risultati preliminari su cellule mononucleate

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    Riccò, Sarah

    2010-01-01

    Negli ultimi anni è emerso l’uso delle MSCs (multipotent mesenchymal stromal cells) nella medicina rigenerativa soprattutto per la terapia dei tendini e dei legamenti nel cavallo. La terapia con MSCS allogeniche potrebbe essere un utile strumento quando non è possibile isolare e amplificare le cellule del paziente. L’attività immunomodulatrice delle MSCS è stata studiata in diverse specie animali e nell’uomo ma nessun dato è stato riportato nel cavallo. In questo lavoro abbiamo riportato la c...

  16. Detección de parásitos intestinales en agua y alimentos de Trujillo, Perú

    OpenAIRE

    Gregorio Pérez-Cordón; María J. Rosales; Renzo A. Valdez; Franklin Vargas-Vásquez; Ofelia Cordova

    2008-01-01

    Detectamos distintas especies de parásitos intestinales, tanto protozoos como helmintos, presentes en muestras de agua provenientes de acequias y pozos (Giardia lamblia, Blastocystis hominis, Entamoeba coli, Cyclospora cayetanensis, Cryptosporidium spp. y Balantidium coli), así como en alimentos crudos y cocidos (Giardia lamblia, Cyclospora cayetanensis., Endolimax nana, Iodamoeba butschlii y Blastocystis hominis Fasciola hepatica y Ascaris lumbricoides) recolectadas en varios distritos de la...

  17. Parasitosis intestinales en relación con la cultura higiénica de poblaciones rurales de Catamarca.

    Directory of Open Access Journals (Sweden)

    Monferrán, M. C.

    2003-01-01

    Full Text Available Los estudios realizados sobre prevalencia de parasitosis intestinales humanas en comunidades urbanas y rurales en la provincia de Catamarca, revela altos índices. Las causas son múltiples, entre las que se encuentran factores ecológicos y sociales. Las condiciones climáticas imperantes en una zona geográfica resultaran favorables o no a la presentación de algunas parasitosis como por ejemplo las geohelmintiasis.Se atribuye igual importancia a la educación, vivienda, alimentación, recursos económicos, falta de higiene, contaminación ambiental, etc.. Se realizan estudios de prevalencia de parasitosis intestinales en pobladores de dos regiones climáticamente diferentes de nuestra provincia como son los Dptos. La Paz y Paclín detectándose en algunas comunidades índices altos de hasta el 81 %.También se ha notado la influencia climática regional sobre la distribución de las parasitosis intestinales .En La Paz, existe un predominio de las protozoosis y en Paclín las geohelmintiasis son frecuentes y diversas. Las parasitosis detectadas estarían relacionadas en un alto grado a la denominada cultura higiénica, pues las prácticas de la higiene individual y familiar, la deposición de sus excretas, la convivencia con animales domésticos, el manejo de sus rebaños, son costumbres regionales que se han transmitido por generaciones e influyen notablemente en la difusión y la conservación de estos altos índices de parasitosis intestinales en detrimento de la salud de los habitantes.

  18. Valutazione della flora batterica intestinale in pazienti con diverso stato di nutrizione confrontando metodiche colturali e di biologia molecolare

    OpenAIRE

    Iervolino, Carmela

    2014-01-01

    Introduzione L’intestino umano rappresenta un ecosistema in cui miliardi di batteri interagiscono con l’organismo ospite rappresentando un “organo metabolico” capace di regolare molte funzioni sistemiche e contribuire allo stato di salute. Scopo dello studio Il nostro studio si propone di esaminare possibili differenze nella composizione della flora batterica intestinale e nel contenuto di acidi grassi fecali a catena corta (SCFA) in 84 soggetti suddivisi in 5 grupp...

  19. Distribución espacial de las parasitosis intestinales en la ciudad de La Plata, Argentina

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    María I Gamboa

    2014-10-01

    Full Text Available El análisis de las parasitosis a diferentes escalas (regional, local se facilita por el Geographic Information System (GIS, que permite identificar áreas con distinto grado de vulnerabilidad. El objetivo del trabajo fue analizar la distribución espacial de las parasitosis intestinales en el partido de La Plata, estableciendo su relación con las condiciones socio-ambientales para identificar áreas con diferente riesgo epidemiológico. Se completó una encuesta epidemiológica y se tomaron muestras seriadas de materia fecal, analizadas por la técnica de Ritchie. Se calcularon niveles de precariedad y vulnerabilidad (Iv, y se compararon con los resultados parasitológicos. Se analizaron parasitológica y ambientalmente 653 personas, de las cuales 585 (89.6% eran niños y 68 (10.4% adultos. El análisis indicó que los más vulnerables (Iv = 3-4 estaban en el sector con menor acceso a servicios de infraestructura urbana. El índice se encontró fuertemente asociado a la prevalencia total de parasitosis intestinales y a las 4 especies patógenas asociadas a la contaminación fecal del ambiente: Trichuris trichiura, Ascaris lumbricoides, Hymenolepis nana y Giardia lamblia (p < 0.01. Enterobius vermicularis, parásito no vinculado a la condición sanitaria de sus hospedadores, no se asoció al Iv. Hubo asociación estadística entre precariedad y parasitosis y se halló que a mayor Iv mayor frecuencia de parasitosis (p < 0.01. El uso de GIS permitió zonificar las variables socioambientales en un gradiente creciente de condiciones desfavorables y su relación con la presencia de especies patógenas. La continuidad de estos estudios en diferentes regiones de Argentina contribuye a la determinación de áreas en riesgo sanitario.

  20. Clinical and microbiologic features of dacryocystitis-related orbital cellulitis.

    Science.gov (United States)

    Wladis, Edward J; Shinder, Roman; LeFebvre, Daniel R; Sokol, Jason A; Boyce, Michelle

    2016-10-01

    Dacryocystitis-related orbital cellulitis is a relatively rare condition, and large case series of this clinical entity have been reported. This study was undertaken to identify a larger cohort of patients with this ailment, with the intent of defining its clinical and microbiologic features. Case logs from four institutions were reviewed to identify patients that suffered from dacryocystitis-related orbital cellulitis. A retrospective chart review was then performed to identify clinical features, management strategies, microbiologic features, and outcomes. A dedicated statistical software package was utilized to identify correlations between these variables. 13 patients (7 females, 6 males; mean age = 57.2 years, range = 7-89 years) were identified. One patient carried a diagnosis of immunosuppressive disease. All patients underwent emergent surgical drainage and received intravenous antibiotics. Primary acquired nasolacrimal duct obstruction was found to be the underlying etiology in nine cases (69.2%), whereas four patients suffered from specific causes of their obstructions. An average of 1.07 organisms/patient (standard deviation = 0.49 organisms/patient) were recovered from microbiologic cultures, and Gram-positive bacteria represented the majority of cultured organisms. All patients experienced either stable or improved vision upon discharge. The relationships between a specific etiology and the possibility of vision loss or the number of organisms cultured, between the number of organisms cultured and vision loss, and immunosuppression and vision loss or the number of organisms cultured were all not statistically significant (p > 0.05). Dacryocystitis-related orbital cellulitis most commonly occurs in adult patients who do not carry immunosuppressive diagnoses and suffer from primary obstructions. Multiple microbiologic species may cause this problem, although Gram-positive organisms are most common. With appropriate management, stable or improved vision

  1. Antimicrobial resistance of bacterial strains isolated from avian cellulitis

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    MM Santos

    2014-03-01

    Full Text Available Avian cellulitis is an inflammatory process in the subcutaneous tissue, mainly located in the abdomen and thighs. This problem is commonly observed in poultry at slaughter and it is considered one of the major causes of condemnation of carcasses in Brazil. The aim of this study was to perform the microbial isolation of lesions of avian cellulitis from a processing plant located in the State of Goiás in order to analyze antimicrobial resistance by antibiogram test and to detect resistance genes by polymerase chain reaction. A total of 25 samples of avian cellulitis lesions were analyzed, from which 30 bacterial strains were isolated. There were eleven (44% strains of Escherichia coli, nine (36% strains of Staphylococcus epidermidis, seven (28% strains of Proteus mirabilis and three (12% strains of Manheimiahaemolytica. The antibiogram test showed that all strains were resistant to at least one antimicrobial. The gene of antimicrobial resistance tetB was detected in E. coli, S. epidermidis and P. mirabilis strains, and was the most frequently observed gene. The gene of antimicrobial resistance Sul1 was detected in all bacterial species, while tetA was found in E. coli and S. epidermidis strains, SHV in E. coli strains, S. epidermidis and P. mirabilis,and cat1 in one P. mirabilis strain. The results suggest a potential public health hazard due to the ability of these microorganisms to transmit antimicrobial resistancegenes to other microorganisms present in the intestinal tract of humans and animals, which may affect clinical-medical usage of these drugs.

  2. Prevalence and Epidemiological Factors Involved in Cellulitis in Korean Patients With Lymphedema

    Science.gov (United States)

    Park, Sae In; Yang, Eun Joo; Kim, Dong Kyu; Jeong, Ho Joong; Kim, Ghi Chan

    2016-01-01

    Objective To evaluate the prevalence and associated factors involved in cellulitis with lymphangitis among a group of Korean patients who were being treated for lymphedema. We present our epidemiologic research and we also report a systematic review of these types of cases. Methods This was a retrospective medical record study among 1,246 patients diagnosed with lymphedema. The study was carried out between January 2006 and December 2012 at the Kosin University Gospel Hospital and Seoul National University Bundang Hospital. Cases were examined for onset time, affected site, seasonal trend, and recurrence pattern of lymphedema, lymphangitis, and cellulitis. We also evaluated the history of blood-cell culture and antibiotic use. Results Ninety-nine lymphedema patients experienced complications such as cellulitis with accompanying lymphangitis. Forty-nine patients had more than two recurrences of cellulitis with lymphangitis. The incidence and recurrence of cellulitis with lymphangitis were significantly higher in the patients with lower-extremity lymphedema. There was a significant trend toward higher cellulitis prevalence in the lower-extremity lymphedema group according to the time of lymphedema onset. Among the cellulitis with lymphangitis cases, 62 cases were diagnosed through blood-cell culture; 8 of these 62 cultures were positive for β-hemolytic streptococci. Conclusion The prevalence rate of cellulitis with lymphangitis in patients with lymphedema was 7.95%, and the prevalence of recurrent episodes was 3.93%. Especially, there was high risk of cellulitis with lymphangitis after occurrence of lower-extremity lymphedema with passage of time. Lymphedema patients should be fully briefed about the associated risks of cellulitis before treatment, and physicians should be prepared to provide appropriate preventive education. PMID:27152284

  3. Erosive pustular dermatosis of the leg mimicking lower limb cellulitis.

    Science.gov (United States)

    Zhou, Z; Zhang, Z K; Liu, T H

    2015-12-01

    Erosive pustular dermatosis (EPD) of the leg is an unusual form of amicrobial pustulosis, which typically affects elderly patients with chronic venous insufficiency. We report a patient who presented with painful erythema, crusted erosions and pustules on her right lower leg. Histology showed a dermal infiltration made up predominantly of neutrophils. Bacteria were isolated from the lesions. The condition was initially diagnosed as cellulitis, but antibiotic treatment was unsuccessful. After the correct diagnosis was made, complete resolution was obtained with betamethasone 0.05%. PMID:25476720

  4. Intestinal parasitic infections, cysticercosis and hydatic diseases Parasitosis intestinales, cisticercosis e hidatidosis

    Directory of Open Access Journals (Sweden)

    David Botero

    1990-03-01

    Full Text Available

    This paper offers an up to date review of the intestinal parasitic infections, cysticercosis and hydatic disease found In Colombia. Their main epidemiological, clinical, preventive and therapeutic features are presented, to provide the reader with a current view of their public health Importance, prevalence and impact on morbidity and mortality.

    Se presenta una revisión actualizada sobre las parasitosis intestinales, la cisticercosis y la hidatidosis en Colombia, con una breve descripción de la prevalencia, las características epidemiológicas, los efectos sobre la salud y algunos aspectos de control y tratamiento. Con esta revisión se busca tener información resumida sobre las parasitosis que se encuentran en Colombia y su mayor o menor Importancia en salud pública. TambIén se pretende ofrecer una Idea del nivel de gravedad de estas entidades como causas de morbilidad y mortalidad en este país. 

  5. Acute neck cellulitis and mediastinitis complicating a continuous interscalene block.

    Science.gov (United States)

    Capdevila, Xavier; Jaber, Samir; Pesonen, Pertti; Borgeat, Alain; Eledjam, Jean-Jacques

    2008-10-01

    We report a case of acute neck cellulitis and mediastinitis complicating a continuous interscalene brachial plexus block. A 61-yr-old man was scheduled for an elective arthroscopic right shoulder rotator cuff repair. A continuous interscalene block was done preoperatively and 20 mL of 0.5% bupivacaine and 20 mL of 2% mepivacaine were injected through the catheter. Postoperative analgesia was provided by a continuous infusion of bupivacaine, 0.25% at 5 mL/h for 39 h using a 240-mL elastomeric disposable pump. The day after surgery, the patient complained of neck pain. The analgesic block was not fully effective. He was discharged home. Three days later, the patient was readmitted with neck edema and erythema, fever and fatigue. Neck ultrasonography and computed tomographic scan revealed an abscess of the interscalene and sternocleidomastiod muscles and cellulitis, as well as acute mediastinitis. Two blood cultures and surgical samples were positive for Staphylococcus aureus. The infection was treated with surgery, the site was surgically debrided, and a 2-mo course of vancomycin, imipenem, and oxacilline. The technique of drawing local anesthetic from the bottle and filling the elastomeric pump was the most likely cause of infection. This case emphasizes the importance of strict aseptic conditions during puncture, catheter insertion, and management of the local anesthetic infusate. PMID:18806062

  6. Frecuencia de parásitos intestinales en expendedores de alimentos ubicados en los recintos de la UNAN-León

    OpenAIRE

    Cortés Selva, Diana Margarita; Estrada Leytón, Martha Raquel; Areas Barrera, Karla Yessenia; Téllez Sierra, Aleyda

    2008-01-01

    Se realizó un estudio de corte transversal en expendedores de alimentos ubicados en los recintos de la UNAN-León para determinar la frecuencia de parásitos intestinales. Durante los meses de Mayo a Julio se estudiaron un total de 40 individuos a cada uno se le tomó una muestra fecal y se le realizó una encuesta para medir el grado de conocimiento sobre los mecanismos de transmisión de parásitos intestinales. Las muestras fueron analizadas en el laboratorio del departamento de Microbiología y ...

  7. Caracterisations des cellules photovoltaiques a base des ôlymeres conducteurs

    OpenAIRE

    ANSRI, Amel

    2012-01-01

    Ce travail de recherche est porté sur la caractérisation des cellules photovoltaïques organiques. Le développement de ces cellules constitue un grand enjeu de la filière électronique organique. Ces cellules sont aussi prometteuses pour la production d'énergie à bas coût. Elles peuvent être fabriquées sur substrat souple, ce qui leur permettra une intégration facile dans les appareils nomades comme les téléphones portables et les ordinateurs portables. Dans ce cadre et dans le but ...

  8. Prevalencia de parásitos intestinales en manipuladores de alimentos en una comunidad rural de Cojedes, Venezuela

    OpenAIRE

    Gilberto Bastidas; Carolina Rojas; Elisa Martínez-Silva; Lisbeth Loaiza; María Guzmán; Varuna Hernández; Luis Rodríguez; Flor Rodríguez; Lesbia Meertens

    2012-01-01

    Introducción: las parasitosis intestinales constituyen un problema de salud pública, por la elevada prevalencia que muestran, donde los manipuladores de alimentos parasitados, se convierten en potenciales fuentes de infección, pues algunas formas parasitarias se transmiten directamente de la fuente de infección al susceptible, por vía fecal-oral. A esto se suma el incremento en el consumo de comida fuera del núcleo familiar, en residentes de zonas urbanas y rurales. El objeto es recolectar in...

  9. Effects of lymphatic drainage on cellulitis assessed by magnetic resonance

    Directory of Open Access Journals (Sweden)

    Patrícia Froes Meyer

    2008-12-01

    Full Text Available The aim of this study was to assess the use of magnetic resonance as a new method for evaluating the manual lymphatic drainage technique in treating cellulitis. Cellulitis is one of the main esthetic problems that lead women toward seeking guidance and specific treatments. There are various therapeutic approaches, owing to the multi-factorial nature of its pathogen, although the effectiveness of most of these has not been definitively proven, given that the assessment methods used are mostly subjective or do not provide enough information on subcutaneous tissue. The introduction of magnetic resonance as a means of assessing a lymphatic drainage technique in cellulitis treatment makes the evaluation more accurate, since it enables a detailed study of subcutaneous architecture.Objetivo: Este estudo objetiva avaliar o uso da Ressonância Magnética como uma nova técnica de avaliação de uma técnica de drenagem linfática no tratamento do Fibro Edema Gelóide (FEG. O FEG, popularmente conhecido como "celulite" é um dos principais problemas de estética corporal que leva as mulheres a procurar orientações e tratamentos específicos. Devido à natureza multifatorial da sua patogenia, existem várias abordagens terapêuticas, mas a maioria desses não tem sua eficácia comprovada de maneira acurada, pois os métodos de avaliação utilizados, em sua maioria, são subjetivos ou não provêem informações suficientes para o estudo do tecido subcutâneo. A introdução da ressonância magnética como meio de avaliação de uma técnica de drenagem linfática no tratamento do FEG a torna mais acurada, uma vez que a mesma possibilita o estudo detalhado da arquitetura do subcutâneo.

  10. Acetaminophen-induced cellulitis-like fixed drug eruption

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    Neila Fathallah

    2011-01-01

    Full Text Available Acetaminophen is a widely used analgesic drug. Its adverse reactions are rare but severe. An 89-year-old man developed an indurated edematous and erythematous plaque on his left arm 1 day after acetaminophen ingestion. Cellulitis was suspected and antibiotictherapy was started but there was no improvement of the rash; there was a spectacular extension of the lesion with occurrence of flaccid vesicles and blisters in the affected sites. The diagnosis of generalized-bullous-fixed drug eruption induced by acetaminophen was considered especially with a reported history of a previous milder reaction occurring in the same site. Acetaminophen was withdrawn and the rash improved significantly. According to the Naranjo probability scale, the eruption experienced by the patient was probably due to acetaminophen. Clinicians should be aware of the ability of acetaminophen to induce fixed drug eruption that may clinically take several aspects and may be misdiagnosed.

  11. Prospective study on sociodynamics of cellulitis in general surgical unit

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    Didde Sundara Chakravarthy

    2015-05-01

    Results: The median age of the participants was 62.5 years. The following risk factors were strongly and independently associated with cellulitis and outcome of the patient; illiteracy (OR, 4; P value 0.010, age above 50 years (OR, 0.110; P value 0.000, residing in rural areas (OR, 4.008; P value 0.006, low socioeconomic status (OR, 0.241; P value 0.030 and associated co-morbid conditions (OR, 0.390; P value, 0.032. Conclusion: Patients usually presented in the late stage of disease because of illiteracy, ignorance and poor knowledge. Patients should be educated to routinely inspect their feet, and the importance of appropriate footwear should be emphasized. Patients who are actively involved in their care can improve their quality of life and have a better outcome. [Int J Res Med Sci 2015; 3(5.000: 1052-1055

  12. Recurrent cellulitis with benzathine penicillin prophylaxis is associated with diabetes and psoriasis.

    Science.gov (United States)

    Karppelin, M; Siljander, T; Huhtala, H; Aromaa, A; Vuopio, J; Hannula-Jouppi, K; Kere, J; Syrjänen, J

    2013-03-01

    Risk factors for recurrent cellulitis were assessed in a case-control study including 398 patients receiving prophylactic treatment with benzathine penicillin and 8,005 controls derived from a national population-based health survey. In the multivariate analysis, psoriasis [odds ratio (OR) 3.69], other chronic dermatoses (OR 4.14), diabetes (OR 1.65), increasing body mass index (OR 1.17), increasing age (OR 1.06) and history of previous tonsillectomy (OR 6.82) were independently associated with recurrent cellulitis. Forty percent of the patients reported a cellulitis recurrence, despite ongoing benzathine penicillin prophylaxis. The role of previous tonsillectomy in recurrent cellulitis needs further evaluation. PMID:23007460

  13. Histiocytoid giant cellulitis-like Sweet’s syndrome: case report and review of the literature

    OpenAIRE

    So, Jessica Kim; Carlos, Casey A; Frucht, Corey S.; Cohen, Philip R.

    2015-01-01

    Background: Histiocytoid Sweet syndrome is an uncommon variant in which the dermal infiltrate is composed of mononuclear cells with a histiocytic appearance that represent immature myeloid cells. Giant cellulitis-like Sweet syndrome is a recently described variant characterized by relapsing widespread giant lesions. Purpose: We report a unique patient with histiocytoid giant cellulitis-like Sweet syndrome and review the current literature on histiocytoid Sweet syndrome and giant cell...

  14. Is Procalcitonin a usefull biomarker for the risk stratification of facial cellulitis?

    OpenAIRE

    Bertolus, Chloé; Schouman, Thomas; Aubry, Adeline; Hausfater, Pierre

    2016-01-01

    International audience Backgroundfacial cellulitis is an infectious disease that may require emergency surgical drainage based on clinical assessment. To date, no biological marker has been reported to be useful for risk stratification. Procalcitonin (PCT) is a diagnostic and prognostic sepsis biomarker. We aimed to study the usefulness of PCT dosage for the risk-stratification of facial cellulitis.Patients and methodsThis was a monocentric prospective study conducted in a referral center ...

  15. Peg-Interferon Alfa 2-b Related Cellulitis in a 40 Years Man

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    Shahnaaz Sali

    2016-01-01

    Full Text Available Background: Pegylated interferon and ribavirin are currently one of the accepted treatment for chronic Hepatitis C. Dermatologic complications of interferon have been reported, but to date a few cases of bacterial cellulitis; a rare and severe complication, have been published. Cellulitis is a common infectious process affecting the skin and subcutaneous tissues which results in significant morbidity and holds considerable healthcare costs.Cases Report: Herein, we report a case of chronic hepatitis C genotype 1a who was on medication since 8 weeks prior to developing leg cellulitis, an uncommon pegylated interferon injection site. Considering no other possible risk factors were found to be in favor of bacterial cellulitis, our case is unique in its kind. Some reports reveal necrotizing vasculitis as basis for cutaneous lesions, which could be due to the high concentrations of drug at the injection site, a toxic effect of the diluents, or an immunological reaction.Conclusion: According to the latter mechanism patients could develop bacterial cellulitis in their different organs. Conclusively, we propose the hypothesis of a possible association between cellulitis to occur at any site as the complication of pegylated interferon Alfa 2b and would highlight the role of a careful skin examination that could be an asset in preventing local skin infections.

  16. Descripción Morfométrica de las vellosidades Intestinales en bovinos

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    Diana Avila

    2009-10-01

    Full Text Available El objetivo del estudio es realizar la caracterización de los parámetros histológicos del intestino delgado de bovinos adultos sacrificados en la planta debeneficio del municipio de Tunja Boyacá, relacionando la altura, el ancho y la cantidad de vellosidades con la superficie de absorción de nutrientes, para establecer mejores dietas, manejos nutricionales, sanitarios y asociar las patologías digestivas de mayor presentación en los bovinos de nuestra región. Para la metodología del estudio se tomaron muestras de (n=15 animales al azar sacrificados durante una semana. Se les tomaron muestras de intestino delgado (duodeno de 1 x 1cm, conservadas en formol al 10% y enviadas al laboratorio de Patología de la Universidad Nacional sede Bogotá, donde se les practicó la tinción de hematoxilina-eosina (H-E con previa inclusión en bloques de parafina. Las láminas se analizaron en el laboratorio de Ciencias Básicas de la Fundación Universitaria Juan de Castellanos, utilizando un microscopio Model con un aumento 4x y 10x en el objetivo, las mediciones se tomaron en valores de milímetros (mm. Se concluye que por campo observado se encuentran 4 vellosidades con una altura promedio de 0,521 mm y una desviación estándar de 0,13, ancho de 0,10mm y desviación estándar de 0,044. A medida que las vellosidades intestinales se encuentran cercanas a la parte craneal del intestino delgado de observaron en mayor cantidad por campo, más largas, uniformes y con un ancho de mayor longitud, lo que incrementa su superficie interna, facilitando los procesos de digestión y absorción.

  17. Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.

    Science.gov (United States)

    Räßler, F; Lukács, J; Elsner, P

    2016-09-01

    Eosinophilic cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well-designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions. PMID:27357601

  18. Cervical cellulitis and mediastinitis following esophageal perforation: A case report

    Institute of Scientific and Technical Information of China (English)

    Christian A Righini; Basilide Z Tea; Emile Reyt; Karim A Chahine

    2008-01-01

    Chicken bone is one of the most frequent foreign bodies (FB) associated with upper esophageal perforation.Upper digestive tract penetrating FB may lead to life threatening complications and requires prompt management.We present the case of a 52-year-old man who sustained an upper esophageal perforation associated with cervical cellulitis and mediastinitis.Following CT-scan evidence of FB penetrating the esophagus,the impacted FB was successfully extracted under rigid esophagoscopy.Direct suture was required to close the esophageal perforation.Cervical and mediastinal drainage were made immediately.Nasogastric tube decompression,broad-spectrum intravenous antibiotics,and parenteral hyperalimentation were administered for 10 d postoperatively.An esophagogram at d 10 revealed no leak at the repair site,and oral alimentation was successfully reinstituted.Conclusion:Rigid endoscope management of FB esophageal penetration is a simple,safe and effective procedure.Primary esophageal repair with drainage of all affected compartments are necessary to avoid life-threatening complications.

  19. Efecto del butirato de sodio en dietas para gallinas sobre el comportamiento productivo, calidad del huevo y vellosidades intestinales

    OpenAIRE

    Isaías Sánchez Herrera; Elizabeth Posadas Hernández; Ezequiel Sánchez Ramírez; Benjamín Fuente Martínez; Jorge Hernández Espinoza; José Luis Laparra Vega; Ernesto Ávila González

    2009-01-01

    En el presente estudio se evaluó el comportamiento productivo, calidad del huevo y análisis histológico de vellosidades intestinales de duodeno (largo y ancho) en gallinas de la estirpe Bovans, de 63 semanas de edad, con adición de butirato en la dieta (0, 300, 500 ppm). Los resultados obtenidos en diez semanas de experimentación mostraron respuesta (P 0.05) en porcentaje de postura (86.4, 92.2 y 89.6), peso del huevo (63.4, 63.4 y 64.1 g) consumo/ave/día (111.4, 111.9 y 113.4 g), conversión...

  20. Evidence of streptococcal origin of acute non-necrotising cellulitis: a serological study.

    Science.gov (United States)

    Karppelin, M; Siljander, T; Haapala, A-M; Aittoniemi, J; Huttunen, R; Kere, J; Vuopio, J; Syrjänen, J

    2015-04-01

    Bacteriological diagnosis is rarely achieved in acute cellulitis. Beta-haemolytic streptococci and Staphylococcus aureus are considered the main pathogens. The role of the latter is, however, unclear in cases of non-suppurative cellulitis. We conducted a serological study to investigate the bacterial aetiology of acute non-necrotising cellulitis. Anti-streptolysin O (ASO), anti-deoxyribonuclease B (ADN) and anti-staphylolysin (ASTA) titres were measured from acute and convalescent phase sera of 77 patients hospitalised because of acute bacterial non-necrotising cellulitis and from the serum samples of 89 control subjects matched for age and sex. Antibiotic treatment decisions were also reviewed. Streptococcal serology was positive in 53 (69%) of the 77 cases. Furthermore, ten cases without serological evidence of streptococcal infection were successfully treated with penicillin. Positive ASO and ADN titres were detected in ten (11%) and three (3%) of the 89 controls, respectively, and ASTA was elevated in three patients and 11 controls. Our findings suggest that acute non-necrotising cellulitis without pus formation is mostly of streptococcal origin and that penicillin can be used as the first-line therapy for most patients. PMID:25403372

  1. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

    Directory of Open Access Journals (Sweden)

    Juan Carlos Fernández Méndez

    2010-01-01

    Full Text Available En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mostraba valores en neuroticismo que se hallaban dentro de la normalidad; sin embargo, se pudo verificar que los valores diferían dependiendo del curso clínico de la patología. El estudio sugiere que las variaciones en neuroticismo son considerables cuando se analizan los datos de la muestra general y cuando se tienen en cuenta diversas condiciones del curso clínico.

  2. Meccanismi coinvolti nel danno della mucosa celiaca. Determinazione nel siero dell’anticorpo anti-actina: un nuovo test diagnostico nella diagnosi di atrofia intestinale nella malattia celiaca

    OpenAIRE

    Musu, Maria Paola

    2006-01-01

    La celiachia (CD) è un’ enteropatia autoimmune causata dall’ingestione di alcuni cereali contenenti glutine, quali grano, orzo e segale, che colpisce soggetti geneticamente predisposti ed è caratterizzata da una alta variabilità delle manifestazioni cliniche e delle lesioni istologiche della mucosa duodenale. Le attuali metodiche sierologiche consentono solamente di avere un sospetto diagnostico di malattia celiaca e costituiscono l’indicazione ad eseguire una biopsia intestinale per una c...

  3. Identificación de parásitos intestinales en agua de pozos profundos de cuatro municipios. Estado Aragua, Venezuela. 2011-2012

    Directory of Open Access Journals (Sweden)

    Liliana María Gallego Jaramillo

    2014-08-01

    Full Text Available Introducción: el agua subterránea es un recurso natural que se encuentra entre grietas y espacios debajo del suelo, acumulándose en capas de tierra, arena y rocas compuestas por materiales permeables que permiten su movilización, siendo explotada mediante el bombeo en pozos; ésta se contamina con microorganismos patógenos por filtración subterránea de aguas servidas y otros tipos de contaminantes. Objetivos: identificar parásitos intestinales en agua de consumo humano proveniente de pozos profundos en los municipios Girardot (GIR, Francisco Linares Alcántara (FLA, José Ángel Lamas (JAL y Libertador (LIB del estado Aragua-Venezuela. Métodos: se tomaron muestras de agua provenientes de 56 pozos profundos distribuidos en los cuatro municipios, se les aplicó la técnica de concentración por floculación para la recuperación de huevos de helmintos y quistes de protozoarios y la tinción de Kinyoun para el diagnóstico de coccidios y microsporidios intestinales. Resultados: en la recuperación de huevos de helmintos, quistes protozoarios y microspordios intestinales se encontró una prevalencia general de 37,5 %, siendo FLA el de mayor valor (70 %. Se observó la presencia de protozoarios en 90 % de las muestras positivas, las especies más frecuentes correspondieron a Blastocystis sp. y Endolimax nana, solo en FLA se observaron huevos de helmintos. No se evidenció la presencia de coccidios en las muestras analizadas, con respecto a microsporidios se encontró en una muestra de LIB. Conclusión: estos resultados indican la necesidad de tratar el agua para su posterior consumo, dado que representa un importante medio de transmisión para los parásitos intestinales.

  4. Group a streptococcal cellulitis in the early puerperium

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    Nikolić Branka

    2011-01-01

    Full Text Available Introduction. Infectious diseases caused by Streptococcus pyogenes, a member of the group A Streptococci (GAS are among the most common life threatening ones. Patients with GAS infections have a poor survival rate. Cellulitis is a severe invasive GAS infection and the most common clinical presentation of the disease associated with more deaths than it can be seen in other GAS infections. According to the literature data, most cases of GAS toxic shock syndrome are developed in the puerperium. However, there are two main problems with GAS infection in early puerperium and this case report is aimed at reminding on them. The first problem is an absence of awareness that it can be postpartal invasive GAS infection before the microbiology laboratory confirms it, and the second one is that we have little knowledge about GAS infection, in general. Case report. A 32- year-old healthy woman, gravida 1, para 1, was hospitalized three days after vaginal delivery with a 38-hour history of fever, pain in the left leg (under the knee, and head injury after short period of conscious lost. Clinical picture of GAS infection was cellulites. Group A Streptoccocus pyogenes was isolated in vaginal culture. Rapid antibiotic and supportive treatment stopped development of streptococcal toxic shock syndrome (STSS and potential multiorganic failure. Signs and symptoms of the infection lasted 25 days, and complete recovery of the patient almost 50 days. Conclusion. In all women in childbed with a history of fever early after delivery, vaginal and cervical culture specimens should be taken as soon as possible. Early recognition of GAS infection in early puerperium and prompt initiation of antimicrobial drug and supportive therapy can prevent development of STSS and lethal outcome.

  5. Delayed breast cellulitis: An evolving complication of breast conservation

    International Nuclear Information System (INIS)

    Purpose: Delayed breast cellulitis (DBC) is characterized by the late onset of breast erythema, edema, tenderness, and warmth. This retrospective study analyzes the risk factors and clinical course of DBC. Methods and Materials: From 1985 through 2004, 580 sequential women with 601 stage T0-2N0-1 breast cancers underwent breast conserving therapy. Cases of DBC were identified according to accepted clinical criteria: diffuse breast erythema, edema, tenderness, and warmth occurring >3 months after definitive surgery and >3 weeks after radiotherapy. Potential risk factors analyzed included patient comorbidity, operative technique, acute complications, and details of adjunctive therapy. Response to treatment and long-term outcome were analyzed to characterize the natural course of this syndrome. Results: Of the 601 cases, 16%, 52%, and 32% were Stage 0, I, and II, respectively. The overall incidence of DBC was 8% (50/601). Obesity, ecchymoses, T stage, the presence and aspiration of a breast hematoma/seroma, removal of >5 axillary lymph nodes, and arm lymphedema were significantly associated with DBC. The median time to onset of DBC from the date of definitive surgery was 226 days. Ninety-two percent of DBC patients were empirically treated with antibiotics. Fourteen percent required more invasive intervention. Twenty-two percent had recurrent episodes of DBC. Ultimately, 2 patients (4%) underwent mastectomy for intractable breast pain related to DBC. Conclusion: Although multifactorial, we believe DBC is primarily related to a bacterial infection in the setting of impaired lymphatic drainage and may appear months after completion of radiotherapy. Invasive testing before a trial of antibiotics is generally not recommended

  6. A case of community-acquired Acinetobacter junii-johnsonii cellulitis.

    Science.gov (United States)

    Henao-Martínez, Andrés F; González-Fontal, Guido R; Johnson, Steven

    2012-06-01

    Acinetobacter skin and soft tissue infection outside of the traumatic wound setting are rare occurrences. The majority of cases occur in the presence of significant comorbilities and by Acinetobacter baumanii. Herein a case is reported of community-onset, health-care-associated, non-traumatic cellulitis caused by Acinetobacter, species junii-johnsonii with bacteremia. This is the first reported case of Acinetobacter junii-johnsonii skin and soft tissue infection. Hemorrhagic bullae might be one of the clinical features of Acinetobacter cellulitis. PMID:23242290

  7. Etude d'une cellule photovoltaïque à jonction liquide : la cellule GaAs-n/(Se2-/Sen2-)/Pt

    OpenAIRE

    Bourrasse, A.; Cachet, H.; Horowitz, G.; Le Crom, S.

    1982-01-01

    Une étude de la cellule GaAs-n/(Se2- /Sen2- )/Pt, où l'électrode de GaAs est protégée contre la photo-décomposition par le couple redox séléniure/polyséléniure, est présentée. Un rendement énergétique de 11 % sous éclairement par une lampe à arc xénon a été atteint. La cellule a pu fonctionner pendant huit jours sous illumination solaire sans que l'on observe de baisse de ses performances. La faible décomposition de la photoanode est attribuée à la dégradation de l'électrolyte, provoquée par ...

  8. Penetration of Fosfomycin into Inflammatory Lesions in Patients with Cellulitis or Diabetic Foot Syndrome

    OpenAIRE

    Legat, F. J.; Maier, A.; Dittrich, P.; Zenahlik, P.; Kern, T.; Nuhsbaumer, S.; Frossard, M.; Salmhofer, W.; Kerl, H; Müller, M

    2003-01-01

    We investigated the distribution of the broad-spectrum antibiotic fosfomycin in infected soft tissue of patients with uncomplicated cellulitis of the lower extremities or diabetic foot infection using in vivo microdialysis. Our findings suggest that fosfomycin exhibits good and similar penetration into the fluid in the interstitial space in inflamed and noninflamed soft tissue in patients.

  9. Panophthalmitis with orbital cellulitis following glaucoma drainage implant surgery in a pediatric patient

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    Bruno L. B. Esporcatte

    2016-04-01

    Full Text Available ABSTRACT Here we report a case of childhood glaucoma refractory to angle and trabeculectomy surgery. The patient was treated with an Ahmed™ drainage implant that was subsequently complicated by rapid-onset panophthalmitis and orbital cellulitis. Intravenous and intravitreal antibiotic therapy was initiated and the drainage tube was removed. The infectious process resolved within 3 weeks; however, phthisis bulbi developed subsequently.

  10. Factors predisposing to acute and recurrent bacterial non-necrotizing cellulitis in hospitalized patients: a prospective case-control study.

    Science.gov (United States)

    Karppelin, M; Siljander, T; Vuopio-Varkila, J; Kere, J; Huhtala, H; Vuento, R; Jussila, T; Syrjänen, J

    2010-06-01

    Acute non-necrotizing cellulitis is a skin infection with a tendency to recur. Both general and local risk factors for erysipelas or cellulitis have been recognized in previous studies using hospitalized controls. The aim of this study was to identify risk factors for cellulitis using controls recruited from the general population. We also compared patients with a history of previous cellulitis with those suffering a single episode, with regard to the risk factors: length of stay in hospital, duration of fever, and inflammatory response as measured by C-reactive protein (CRP) level and leukocyte count. Ninety hospitalized cellulitis patients and 90 population controls matched for age and sex were interviewed and clinically examined during the period April 2004 to March 2005. In multivariate analysis, chronic oedema of the extremity, disruption of the cutaneous barrier and obesity were independently associated with acute cellulitis. Forty-four (49%) patients had a positive history (PH) of at least one cellulitis episode before entering the study. Obesity and previous ipsilateral surgical procedure were statistically significantly more common in PH patients, whereas a recent (<1 month) traumatic wound was more common in patients with a negative history (NH) of cellulitis. PH patients had longer duration of fever and hospital stay, and their CRP and leukocyte values more often peaked at a high level than those of NH patients. Oedema, broken skin and obesity are risk factors for acute cellulitis. The inflammatory response as indicated by CRP level and leukocyte count is statistically significantly more severe in PH than NH patients. PMID:19694769

  11. ETUDE D’UNE CELLULE SOLAIRE PHOTOVOLTAIQUE A HETEROJONCTION n CdS /pCdTe

    OpenAIRE

    BENZEGHADI, Halima; OUDJAMAA, NABAWIYA

    2014-01-01

    Dans les cellules solaires à hétérojonction, le champ électrique créé par la gradient de la zone de charge d’espace permet de réduire le processus de la recombinaison superficielle. Ceci augmente la conductibilité et les performances des cellules solaires. Le tellurure de cadmium possède des propriétés cristallographiques et électriques très intéressantes le rendant ainsi très recherché pour la fabrication de cellules solaires. Dans cet ordre d’idées nous nous ...

  12. Nine years′ review on preseptal and orbital cellulitis and emergence of community-acquired methicillin-resistant Staphylococus aureus in a tertiary hospital in India

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    Datta G Pandian

    2011-01-01

    Full Text Available Context: Preseptal cellulitis is the commonest orbital disease which frequently needs to be differentiated from orbital cellulitis. Prompt diagnosis and treatment with appropriate antibiotics can prevent vision loss and life-threatening complications of orbital cellulitis. Aims: To describe the clinical profile of cases with preseptal and orbital cellulitis admitted to a tertiary care hospital during a period of nine years. The causative organisms and the clinical outcome were analyzed. Settings and Design : Retrospective descriptive case study done in a tertiary care hospital in South India. Material and Methods: The in-patient records of patients with preseptal and orbital cellulitis were reviewed from 1998 to 2006. The factors reviewed included ocular findings aiding in the distinction of the two clinical conditions, the duration of symptoms, the duration of hospital stay, microbiological culture report of pus or wound swab, blood culture, drugs used for treatment, the response to therapy and complications. Statistical Analysis Used: Descriptive analysis. Results: One hundred and ten cases, 77 patients with preseptal cellulitis and 33 patients with orbital cellulitis were reviewed. Five percent of children and 21% of adults presented with cutaneous anthrax contributing to preseptal cellulitis. Thirty-nine percent cases with orbital cellulitis were caused by methicillin-resistant Staphylococcus aureus (MRSA. Conclusions: This study has helped in identifying organisms which cause orbital infections, especially community-acquired MRSA. It indicates the need for modifying our empirical antimicrobial therapy, especially in orbital cellulitis.

  13. Intestinal nematodes of stray dogs as zoonoses agents in D. Pedrito city (RS-Brazil) Nematodes intestinales de perros callejeros como agentes de zoonosis en la ciudad de D. Pedrito (RS-Brasil)

    OpenAIRE

    Adriane N. Hoffmann; Nilzane Beltrão; Sônia de Avila Botton; Brasil Xavier Caminha; Mario Luiz de la Rue

    2000-01-01

    La prevalencia de nematodes intestinales en perros fue el objetivo de esta investigación, principalmente debido al riego de zoonosis. Fueran analizadas heces de 65 perros aleatoriamente capturados en las calles de la ciudad de D. Pedrito (RS-Brasil). En 43 (66,2%) del total de las muestras analizadas, fueran encontrados huevos de nematodes intestinales, como sigue: Toxocara sp. 1 (1,5%), Ancylostoma sp. 30 (46,2%), Trichuris sp. 6 (9,2%), Ancylostoma sp. / Trichuris sp. 4 (6,2%) y Ancylostoma...

  14. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    OpenAIRE

    Soma Mukherjee; Surbhi Sharma; Laxmi Maru

    2013-01-01

    Ludwig's angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregn...

  15. Características de la infección por geohelmintos intestinales en escolares primarios de la provincia de Las Tunas

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    Rebeca M. Laird Pérez

    2014-08-01

    Full Text Available Se realizó un estudio transversal descriptivo, en el período comprendido entre los meses de septiembre y diciembre de 2004, con el objetivo de caracterizar la infección por geohelmintos intestinales en escolares de la enseñanza primaria de la provincia de Las Tunas. Se estudiaron 1 342 escolares pertenecientes a 35 escuelas de los estratos urbano y rural de los ocho municipios de la provincia. De cada escolar se procesó una muestra de heces por los procedimientos Directo y Kato Katz y se practicó el método de Harada Moris cuando se observaron huevos de ancylostomídeos. A los escolares parasitados por geohelmintos se les determinó su condición clínica. Se obtuvo una prevalencia general de la infección por geohelmintos intestinales del 16,2%, con predominio de la intensidad general de la infección ligera. Los gusanos trichúridos fueron los más observados, asociados a la mayoría de las infecciones con intensidades ligeras y moderadas. Prevaleció el estado clínico asintomático con muy poca morbilidad específica, siendo el dolor abdominal y la diarrea no disentérica los síntomas más frecuentes. Se caracterizó a la provincia de Las Tunas como una zona hipoendémica de geohelmintos intestinales y se recomienda identificar los determinantes de la infección por estos parásitos en la población escolar

  16. Identificación de parásitos intestinales de primates en dos centros de rescate en la amazonía ecuatoriana

    OpenAIRE

    Martin, Sarah; Carrillo Bilbao, Gabriel Alberto; Celi, Maritza; Benitez, Washington

    2011-01-01

    Los primates son reservorios de los patógenos humanos. Si identificamos las enfermedades parasitarias de los primates, puede ser favorable para su conservación. Examinamos las muestras fecales para identificar los parásitos intestinales que se encuentran en las especies de primates en dos centros de rescate en la amazonía ecuatoriana. Estas muestras se analizaron según varios factores como tamaño del grupo, el sexo y la edad. La prevalencia general de protozoarios y de helmintos que se encont...

  17. Mebendazol en el tratamiento de helmintíasis intestinales revisión de literatura y consideraciones de Enfermería

    OpenAIRE

    Kogien, M.; Teixeira, C. A.

    2011-01-01

    Mebendazol es un antihelmíntico de amplio espectro, fármaco de elección para el tratamiento de varios tipos de infecciones parasitarias intestinales, además en la zona de la terapéutica farmacológica la enfermería tiene papel importante sea en la administración de medicamentos o en la nueva zona de actuación que surge para la profesión: la prescripción de medicamentos mediante protocolos o rutinas aprobados. Objetivos: realizar una revisión de literatura acerca de los aspectos farmacológi...

  18. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    OpenAIRE

    Graciela Teresa Navone; María Inés Gamboa; Evelia Edith Oyhenart; Alicia Bibiana Orden

    2006-01-01

    Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Rit...

  19. Dinámica para la identificación de las formas parasitarias microscópicas de los geohelmintos intestinales

    OpenAIRE

    Rebeca Margarita Laird Pérez; Alexander Morales Fontaine

    2015-01-01

    Las estadísticas sobre geohelmintos intestinales, a partir del examen parasitológico de las heces, constituye la espina dorsal de los programas para el control de estos gusanos, pues a partir de ellas se obtiene información útil para la toma de decisiones; no obstante, existen insuficiencias cognoscitivas y en las habilidades para la identificación de formas microscópicas de geohelmintos por parte del personal del laboratorio, así como deficiencias didácticas en el abordaje bibliográfico sobr...

  20. Estado nutricional y parasitosis intestinales en niños residentes en zonas urbana, periurbana y rural del partido de Brandsen (Buenos Aires, Argentina)

    OpenAIRE

    Cesani Rossi, María Florencia; Zonta, María Lorena; Castro, Luis Eduardo; Torres, María Fernanda; Forte, Luis M.; Orden, Alicia Bibiana; Quintero, Fabián; Luis, María Antonia; Sicre, María L.; Navone, Graciela Teresa; Gamboa, María Inés; Oyhenart, Evelia Edith

    2007-01-01

    El presente estudio tuvo como objeto analizar el estado nutricional y las parasitosis intestinales en niños de 3 a 6 años de edad, residentes en zonas urbanas (U), periurbanas (PU) y rurales (R) del partido de Brandsen. La muestra quedó constituida por 600 niños (302 varones y 298 mujeres). Los valores P85#P95 defi...

  1. Bacterias probióticas en leche fermentada. Viabilidad, capacidad competitiva y efecto en la evolución de patologías intestinales

    OpenAIRE

    Tabasco Rentero, Raquel

    2009-01-01

    El siguiente objetivo específico consistía en determinar la capacidad de las cepas probióticas para colonizar el intestino, analizando su aptitud para competir en el tracto gastrointestinal. Para ello, se estudió la potencial capacidad de exclusión competitiva que L. acidophilus LA-5 podría ejercer contra cepas patógenas intestinales, como E. coli O157:H7 y Salmonella enteritidis, ya que estudios previos habían demostrado que de las tres cepas probióticas analizadas, L. acidophilus LA-5 po...

  2. Facing the danger zone: the use of ultrasound to distinguish cellulitis from abscess in facial infections.

    Science.gov (United States)

    Lewis, Dywanda L; Butts, Christine J; Moreno-Walton, Lisa

    2014-01-01

    Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1) emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2) demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3) depict an instance where ultrasound detected an abscess when computed tomography (CT) scan did not. PMID:24851189

  3. Unilateral proptosis and orbital cellulitis in eight African hedgehogs (Atelerix albiventris).

    Science.gov (United States)

    Wheler, C L; Grahn, B H; Pocknell, A M

    2001-06-01

    Eight African hedgehogs (Atelerix albiventris) were presented with unilateral proptosis. Six animals presented specifically for an ocular problem, whereas two had concurrent neurologic disease. Enucleation and light microscopic examination of tissues was performed in five animals, and euthanasia followed by complete postmortem examination was performed in three animals. Histopathologic findings in all hedgehogs included orbital cellulitis, panophthalmitis, and corneal ulceration, with perforation in seven of eight eyes. The etiology of the orbital cellulitis was not determined, but it appeared to precede proptosis. Orbits in hedgehogs are shallow and the palpebral fissures are large, which may predispose them to proptosis, similar to brachycephalic dogs. This clinical presentation was seen in 15% (8/54) of African hedgehogs presented to the Western College of Veterinary Medicine over a 2-yr period from January 1995 to December 1996 and warrants further investigation. PMID:12790427

  4. Étude et réalisation d'une cellule solaire à colorant.

    OpenAIRE

    DEBBAB, Moustafa

    2014-01-01

    Dans ce travail on a réalisé une cellule solaire à colorant DSSC, utilisant comme semi-conducteur le TiO2 qui à un rôle important dans la cellule a qualité de transporteur d‟électrons. Nous utilisons aussi un colorant naturel à base d‟extrait de fraise ayant une valeur d‟absorbance de 0.546 V. Après avoir mis en évidence les problèmes qui se posaient dans l‟élaboration de l‟anode, nous avons varié différents paramètres pour fabriquer ce dernier, en effectuant des dépôts de c...

  5. Expression de P53 dans les tumeurs à cellules géantes osseuses

    OpenAIRE

    Trottet, Cécile

    2001-01-01

    Le gène de la p53 est considéré comme un gène suppresseur de tumeur. Nous avons étudié son expression dans les tumeurs à cellules géantes osseuses (TCG) pour rechercher s'il pouvait être considéré comme un marqueur prédictif de l'évolution dans les TCG. La protéine p53 a été étudiée dans 33 cas de tumeurs à cellules géantes osseuses par immunohistochimie pour analyser son expression et par Single Strand Conformation Polymorphism (SSCP) pour rechercher la présence de mutations dans les tumeurs...

  6. Expression de P53 dans les tumeurs à cellules géantes osseuses

    OpenAIRE

    Trottet, Cécile; Borisch, Bettina; Bonjour, Jean-Philippe

    2005-01-01

    Le gène de la p53 est considéré comme un gène suppresseur de tumeur. Nous avons étudié son expression dans les tumeurs à cellules géantes osseuses (TCG) pour rechercher s'il pouvait être considéré comme un marqueur prédictif de l'évolution dans les TCG. La protéine p53 a été étudiée dans 33 cas de tumeurs à cellules géantes osseuses par immunohistochimie pour analyser son expression et par Single Strand Conformation Polymorphism (SSCP) pour rechercher la présence de mutations dans les tumeurs...

  7. Mycobacterium avium-intracellulare cellulitis occurring with septic arthritis after joint injection: a case report

    Directory of Open Access Journals (Sweden)

    Murdoch David M

    2007-02-01

    Full Text Available Abstract Background Cellulitis caused by Mycobacterium avium-intracellulare has rarely been described. Mycobacterium avium-intracellulare is a rare cause of septic arthritis after intra-articular injection, though the causative role of injection is difficult to ascertain in such cases. Case presentation A 57-year-old with rheumatoid arthritis treated with prednisone and azathioprine developed bilateral painful degenerative shoulder arthritis. After corticosteroid injections into both acromioclavicular joints, he developed bilateral cellulitis centered over the injection sites. Skin biopsy showed non-caseating granulomas, and culture grew Mycobacterium avium-intracellulare. Joint aspiration also revealed Mycobacterium avium-intracellulare infection. Conclusion Although rare, skin and joint infections caused by Mycobacterium avium-intracellulare should be considered in any immunocompromised host, particularly after intra-articular injection. Stains for acid-fast bacilli may be negative in pathologic samples even in the presence of infection; cultures of tissue specimens should always be obtained.

  8. A case of dissecting cellulitis and a review of the literature.

    Science.gov (United States)

    Scheinfeld, Noah S

    2003-02-01

    Dissecting cellulitis (also called perifolliculitis capitis abscedens et suffodiens) manifests with perifollicular pustules, nodules, abscesses and sinuses that evolve into scarring alopecia. It predominantly occurs in African American men between 20-40 years of age, but can occasionally affect other races and women too. Associated musculoskeletal findings are sometimes reported. When it occurs with acne conglobata, hidradenitis suppurativa, and pilonidal cysts, the syndrome is referred to as the follicular occlusion triad or tetrad. Its course is chronic and relapsing, and treatment is often difficult. Medical therapies include isotretinoin, antibiotics, and prednisone. Destructive therapies include X-ray therapy, surgical excision, and skin grafting. Laser epilation of hair follicles is a promising new therapy for dissecting cellulitis. PMID:12639466

  9. Facing the Danger Zone: The Use of Ultrasound to Distinguish Cellulitis from Abscess in Facial Infections

    Directory of Open Access Journals (Sweden)

    Dywanda L. Lewis

    2014-01-01

    Full Text Available Physical exam alone is often insufficient to determine whether or not cellulitis is accompanied by an abscess. Bedside ultrasound can be a valuable tool in ruling out suspected abscess by allowing direct visualization of a fluid collection. The proximity of the infection to adjacent structures can also be determined, thus aiding clinical decision making. Patients with cellulitis near the eye and nose are of particular concern due to the adjacent facial structures and the anatomy of the venous drainage. Accurately determining the presence or absence of an associated abscess in these patients is a crucial step in treatment planning. The purpose of this report is to (1 emphasize the benefits of bedside ultrasound when used in conjunction with the physical exam to rule out abscess; (2 demonstrate the utility of bedside ultrasound in planning a treatment strategy for soft tissue infection; (3 depict an instance where ultrasound detected an abscess when computed tomography (CT scan did not.

  10. Radionuclide imaging in early detection of childhood osteomyelitis and its differentiation from cellulitis and bone infarction

    International Nuclear Information System (INIS)

    In children, radionuclide skeletal imaging with sup(99m)Tc-phosphate compounds is significantly more sensitive than roentgenographic studies in the early detection of osteomyelitis and septic arthritis. The scintigraphic patterns are usually characteristic. Cellulitis and some cases of early infarction are easily differentiated from osteomyelitis. However, some cases of infarction are indistinguishable from osteomyelitis on sup(99m)Tc-phosphate scan. In these cases 67Ga-citrate may prove helpful

  11. Insufficiency fractures of the distal tibia misdiagnosed as cellulitis in three patients with rheumatoid arthritis

    International Nuclear Information System (INIS)

    We describe 3 patients with rheumatoid arthritis who presented with diffuse pain, swelling, and erythema of the distal aspect of the lower extremity, suggestive of either cellulitis or thrombophlebitis, but were found to have insufficiency fractures of the distal tibia. The value of technetium-99m diphosphonate bone scintigraphy in the early recognition of these fractures and a possible explanation for the associated inflammatory symptoms are discussed

  12. Prevalence and Epidemiological Factors Involved in Cellulitis in Korean Patients With Lymphedema

    OpenAIRE

    Park, Sae In; Yang, Eun Joo; Kim, Dong Kyu; Jeong, Ho Joong; Kim, Ghi Chan; Sim, Young-Joo

    2016-01-01

    Objective To evaluate the prevalence and associated factors involved in cellulitis with lymphangitis among a group of Korean patients who were being treated for lymphedema. We present our epidemiologic research and we also report a systematic review of these types of cases. Methods This was a retrospective medical record study among 1,246 patients diagnosed with lymphedema. The study was carried out between January 2006 and December 2012 at the Kosin University Gospel Hospital and Seoul Natio...

  13. A Woman with Unilateral Rash and Fever: Cellulitis in the Setting of Lymphedema

    Directory of Open Access Journals (Sweden)

    Melissa Joseph

    2015-01-01

    Full Text Available Cellulitis in the setting of lymphedema is an uncommon but clinically important presentation to the emergency department. Stagnant lymph is an ideal medium for bacterial growth and progression can be rapid due to decreased ability to fight infection in the affected area. Infections are commonly caused by gram-positive cocci, though blood cultures are often negative. Treatment should be aimed at rapid initiation of antibiotics targeting these species. There may be a role for antibiotic prophylaxis in recurrent cases.

  14. A Rare Case of Orbital Cellulitis Followed by Therapeutic(Orthodontic) Extraction

    OpenAIRE

    Srinivasa Prasad, B.; Govardhan, T.

    2011-01-01

    We report a rare case of orbital cellulitis occurring secondary to a dental infection followed by therapeutic (orthodontic) extraction. A 16 year old female patient presented to the dental office with a left orbital proptosis for the past 4 days. PNS view, CT scan revealed an abscess in relation to medial, lateral superior inferior walls of the orbit associated with naso ethmoidal and left maxillary sinus. Through nasal endoscopy, middle meatus antrostomy and ethmoidectomy was performed for t...

  15. Pseudomonas aeruginosa bacteremia secondary to acute right leg cellulitis: case of community-acquired infection

    OpenAIRE

    Wahab, Asrul Abdul; Rahman, M.M.

    2013-01-01

    Pseudomonas aeruginosa is a gram-negative bacillus that causes wide spectrum clinical infections. However, it is most frequently associated with hospital-acquired infection. In this case a 58-year-old male with underlying hypertension and dyslipidaemia was admitted for acute right leg cellulitis. Pseudomonas aeruginosa was identified from the case, though it was not a usual suspected organism. It might be due to community-acquired infection.

  16. Phalangeal fractures and metacarpophalangeal luxations subsequent to post-traumatic osteomyelitis and cellulitis in a dog.

    Science.gov (United States)

    Langley-Hobbs, S J; Lascelles, B D X

    2004-07-01

    A working Border collie suffered a puncture wound to the metacarpal pad. No fractures or luxations were identified at initial presentation. Treatment was instigated with various antibacterials for a period of months. At subsequent visits, the dog's condition progressed with development of metacarpophalangeal joint luxation and phalangeal fractures secondary to cellulitis and chronic osteomyelitis. Amputation was curative. Prompt treatment of the acute condition with debridement and drainage may have prevented osteomyelitis becoming established in the first instance. PMID:15266860

  17. Infratemporal fossa cellulitis caused by a remnant iatrogenic foreign body after a bimaxillary operation.

    Science.gov (United States)

    Park, Do Yang; Choo, Oak-Sung; Hong, Sang Young; Kim, Hyun Jun

    2015-05-01

    Infratemporal fossa cellulitis is rare and mostly occurs because of sinusitis and dental procedures. Furthermore, cellulitis caused by iatrogenic foreign bodies is very rare. A 28-year-old woman who had previously undergone cosmetic bimaxillary operation visited our hospital complaining of left facial swelling, oppressive pain, and nasal obstruction since 2 years. She had been attending another clinic, but despite having additional procedures and taking medications, her symptoms persisted. A subsequent operation was performed, during which we found a remnant surgical gauze from the previous operation, which was decomposed and trapped around the necrotic soft tissue and had eroded the bony structure around the pterygoid fossa. The material was successfully removed by endoscopic surgery, and the necrotic tissue was debrided. After the operation, all symptoms disappeared, and the patient was discharged without sequelae. During any procedure, surgeons must meticulously check for remnant material. Additionally, physicians must carefully note patient history and perform a physical examination, even in patients without serious symptoms. We report a case of advanced infratemporal fossa cellulitis due to remnant gauze material during a previous operation that was undetected. PMID:25950522

  18. [Cervico-facial cellulitis during pregnancy: about a series of 10 cases in Mali].

    Science.gov (United States)

    Doumbia-Singare, K; Timbo, S K; Keita, M; Ag Mohamed, A; Guindo, B; Soumaoro, S

    2014-12-01

    The objective of this work was to analyze the predisposing factors, diagnostic and therapeutic aspects of cervico-facial cellulitis on pregnancies and to determine maternal-fetal prognosis. We conducted a longitudinal observational descriptive study from January 2011 to March 2013 including records from pregnant women with cervicofacial cellulitis treated at the Oto-Rhino-Laryngology (ORL) and cervico-facial surgery department at Gabriel Touré Hospital in Bamako. Ten women met our inclusion criteria. The median age was 23 years. The entry way was dental in all cases. Three women had taken antibiotics and 3 others antibiotics associated with non steroidal anti-inflammatory. The medico-surgical treatment had permitted to cure 8 cases. Two cases of death were recorded and 4 cases of stillbirths. The cervico-facial cellulitis during pregnancy is a serious pathology that can be life-threatening to the mother and or child. Prevention is based on the control of dental status and informing women about the importance of dental hygiene. PMID:25304000

  19. European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate

    Directory of Open Access Journals (Sweden)

    Tsironi Evangelia E

    2012-05-01

    Full Text Available Abstract Background Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed description of a community-associated methicillin-resistant S. aureus ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial acquisition and treatment selection are also discussed. Case presentation A 28-day-old Caucasian boy was referred to our hospital with the diagnosis of right orbital cellulitis. His symptoms included right eye proptosis, periocular edema and redness. Empirical therapy of intravenous daptomycin, rifampin and ceftriaxone was initiated. The culture of pus yielded a methicillin-resistant S. aureus isolate and the molecular analysis revealed that it was a Panton-Valentine leukocidine-positive ST80 strain. The combination antimicrobial therapy was continued for 42days and the infection was successfully controlled. Conclusions Clinicians should be aware that young infants, even without any predisposing condition, are susceptible to orbital cellulitis caused by community-associated methicillin-resistant S. aureus. Prompt initiation of the appropriate empirical therapy, according to the local epidemiology, should successfully address the infection, preventing ocular and systemic complications.

  20. Contribution à l’amélioration des performances des cellules solaires à base de InGaN.

    OpenAIRE

    Mostefaoui, Mohamed Amine

    2015-01-01

    L’énergie photovoltaïque convertit directement l’énergie Lumineuse en énergie électrique par des cellules solaires. Selon les besoins, l’électricité produite peut être utilisée pour l’alimentation d’un site isole ou revendue en tout ou partie au réseau de Distribution. Ce travail consiste à étudier et simuler une cellule solaire à base du matériau InGaN. Après avoir rappelé les caractéristiques d’une cellule solaire, l’influence des différents paramètres sur les caractéristi...

  1. Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Soma Mukherjee

    2013-01-01

    Full Text Available Ludwig′s angina is an infectious process involving submandibular, sublingual, and submental spaces that can rapidly progress to hemodynamic instability and airway obstruction. A 38-year-old unbooked multipara of low socioeconomic status with a poor oral and dental hygiene presented with bilateral submandibular cellulitis and intrauterine fetal demise. She delivered vaginally, and subsequently drainage was done for cellulitis. The report highlights the importance of dental hygiene during pregnancy, lest life-threatening complications like Ludwig′s angina occur, complicating the course of pregnancy.

  2. Amelioration_du_Rendement_Energetique_de_Cellules_Photovoltaïques_en_Couches_Minces_a_base_de_CZTS.

    OpenAIRE

    BOUDJERAD_epouse_MEGHNINE, Fatiha

    2014-01-01

    Dans le contexte global de la diversification de l’utilisation des ressources naturelles, le recours aux énergies renouvelables et en particulier le solaire photovoltaïque se fait de plus en plus fort. A ce titre, le développement d’une nouvelle génération de cellules photovoltaïques à base de CuZnSnS4 (CZTS) semble prometteur. En effet, le rendement de ces cellules a dépassé les 30% ces dernières années. Dans ce travail de modélisation et de simulation, nous utilisons le logic...

  3. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    Directory of Open Access Journals (Sweden)

    Navone Graciela Teresa

    2006-01-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p < 0,01; defecación a cielo abierto, ausencia de calzado y ancilostomídeos (p < 0,01; el tipo de vivienda y los helmintos en general (p < 0,01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  4. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    Directory of Open Access Journals (Sweden)

    Graciela Teresa Navone

    2006-05-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p < 0,01; defecación a cielo abierto, ausencia de calzado y ancilostomídeos (p < 0,01; el tipo de vivienda y los helmintos en general (p < 0,01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  5. Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis

    Directory of Open Access Journals (Sweden)

    Giuseppe Valacchi

    2015-08-01

    Full Text Available Objectives: Ambient air pollution, as many publications indicate, may have associations with skin condition. The aim of this study has been to examine such common relations for cellulitis and pharyngitis. The hypothesis is that ambient ground-level ozone may help bacteria to penetrate skin or throat. Material and Methods: We used the emergency department (ED visits data in Edmonton, Canada for the period from 1992 (April to 2002 (March. We retrieved all the diagnosed ED visits for cellulitis and pharyngitis. Case-crossover design was used to study potential association between ozone and those visits. Conditional logistic regression was used to estimate odds ratios (OR and their 95% confidence intervals (95% CI. Results: The results are reported for the interquartile range (IQR = 17.9 ppb for 8 h maximum ozone. Positive and statistical significant results were obtained as follows: for lags from 0 to 3 (OR = 1.07, 95% CI: 1.03–1.12, lag 2; for lags from 0 to 6 days (OR = 1.08, 95% CI: 1.03–1.12, lag 3; for lags from 0 to 4 (OR = 1.06, 95% CI: 1.03–1.09, for lag 2 and 3. Conclusions: The findings suggest the response to exposure to ambient ground-level ozone for skin and pharyngitis considered separately and jointly.

  6. A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.

    LENUS (Irish Health Repository)

    Quirke, M

    2014-11-01

    To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-referral, symptom duration of more than 48 hours and absence of pre-EO antibiotic therapy.

  7. Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis

    Directory of Open Access Journals (Sweden)

    Rebecca Sin Mei Lim

    2013-01-01

    Full Text Available We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.

  8. Intestinal nematodes of stray dogs as zoonoses agents in D. Pedrito city (RS-Brazil Nematodes intestinales de perros callejeros como agentes de zoonosis en la ciudad de D. Pedrito (RS-Brasil

    Directory of Open Access Journals (Sweden)

    Adriane N. Hoffmann

    2000-07-01

    Full Text Available La prevalencia de nematodes intestinales en perros fue el objetivo de esta investigación, principalmente debido al riego de zoonosis. Fueran analizadas heces de 65 perros aleatoriamente capturados en las calles de la ciudad de D. Pedrito (RS-Brasil. En 43 (66,2% del total de las muestras analizadas, fueran encontrados huevos de nematodes intestinales, como sigue: Toxocara sp. 1 (1,5%, Ancylostoma sp. 30 (46,2%, Trichuris sp. 6 (9,2%, Ancylostoma sp. / Trichuris sp. 4 (6,2% y Ancylostoma sp. / Toxocara sp. 2 (3,0%. Los resultados indican alta prevalencia de animales infectados lo que posibilita una posterior contaminación ambiental que es un un serio factor de riesgo para seres humanos

  9. Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases

    Directory of Open Access Journals (Sweden)

    Souleymane Brah

    2011-01-01

    Full Text Available Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. We describe three cases of severe infection due to C. fetus with cellulitis at presentation, but without any gastrointestinal symptoms, occurring in patients with acquired hypogammaglobulinemia.

  10. Rôle des régulateurs post-transcriptionnels Pumilio 1 et Pumilio 2 dans les cellules souches hématopoïétiques murines

    OpenAIRE

    Michelet, Fabio

    2013-01-01

    Les propriétés centrales des cellules souches sont la pluripotence et la capacité d'auto-renouvellement. Les cellules souches hématopoïétiques (CSHs) sont dotées de ces caractéristiques qui leur permettent de générer toutes les cellules du compartiment hématopoïétique, tout en maintenant en parallèle leur compartiment. Nous menons des approches visant à amplifier ex vivo les CSHs en les activant par HOXB4 exogène (CSHs humaines) ou via la signalisation Notch/DLL-4 (CSHs murines). Or deux anal...

  11. Pneumatose intestinal Pneumatosis intestinales

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Veloso

    2001-10-01

    Full Text Available Pneumatosis Intestinalis (PI is the presence of gas-filled cysts within the wall of the gastrointestinal tract (GIT. It is a clinical and/or radiological sign associated with a wide spectrum of diseases, so that it has a variable clinical significance. Probably, its prevalence is increasing. The nature of the diseases causing PI is been modifying in last decades. Peptic ulcers were its main cause in the past. Nowadays, probably, immunosuppressive conditions and states of increased permeability of the GIT mucosa (AIDS, transplanted patients or in chemotherapy, etc are more common causes. PI can be shown on simple abdominal roentgenograms and computed tomographic scans obtained with lung windows. Its diagnosis include definition of the cause in addition to its presence. The treatment should be directed to the cause of the PI, fluctuating from expectant to emergency laparotomy. The present report is a contribution to the limited literature experience in this topic and calls attention to the importance of recognizing PI and its clinical significance in order to define the right conduct.

  12. Effet du stress oxydant sur les cavéoles dans les cellules musculaires squelettiques

    OpenAIRE

    Mougeolle, Alexis

    2014-01-01

    La sarcopénie est une maladie dégénérative liée à l’âge qui se caractérise par une perte progressive et involontaire de la masse et de la force musculaire. Elle s’accompagne d’une atteinte de la régénération musculaire et d’une accumulation des espèces réactives de l’oxygène. Les cavéoles sont des invaginations de la membrane plasmique. Dans le muscle, elles jouent un rôle dans la différenciation des cellules satellites et dans le maintien de l’unité contractile dans le muscle différencié. Ce...

  13. Facial and Periorbital Cellulitis due to Skin Peeling with Jet Stream by an Unauthorized Person

    Directory of Open Access Journals (Sweden)

    Asli Feride Kaptanoglu

    2014-01-01

    Full Text Available Technologies and devices for cosmetic procedures are developing with each passing day. However, increased and unauthorized use of such emerging technologies may also lead to increases in unexpected results and complications as well. Here, we report a case of facial cellulitis after a “beauty parlor” session of skin cleaning with jet stream peeling device in 19-year old female patient for the first time. Complications due to improper and unauthorized use of jet stream peeling devices may also cause doubts about the safety and impair the reputation of the technology as well. In order to avoid irreversible complications, local authorities should follow the technology and update the regulations where the dermatologists should take an active role.

  14. Cellules photo-électrochimiques à électrodes semiconductrices pour la conversion et le stockage de l'énergie solaire

    OpenAIRE

    Horowitz, G.; Bourrasse, A.

    1980-01-01

    Discipline récente, la conversion photo-électrochimique (PEC) de l'énergie solaire a connu ces dernières années un important effort de recherche. Les cellules PEC se caractérisent par la présence d'électrodes semiconductrices. L'étude théorique de leur fonctionnement, et en particulier de la stabilité des électrodes semiconductrices, conduit à distinguer deux types de cellules : les cellules autorégénérées, fournissant de l'énergie électrique, et les cellules de stockage, permettant la généra...

  15. 眼外伤致眶蜂窝组织炎的护理%Nursing of Oribital Cellulitis Caused by Eye Injury

    Institute of Scientific and Technical Information of China (English)

    林丽萍; 胡淑英; 陈少娜

    2002-01-01

    To sum up 20 cases of nursing Oribital cellulitis caused by eye injury and suggest that it is important fornursing to pay close attention to patient's condition, to prevent cross infection and psychological nursing and to publicizehygiene element knowledge.

  16. Computed tomographic patterns of orbital cellulitis due to sinusitis Padrões tomográficos de celulite orbitária secundária à sinusite

    OpenAIRE

    Filipe José Pereira; Antonio Augusto Velasco e Cruz; Wilma Teresinha Anselmo-Lima; Jorge Elias Júnior

    2006-01-01

    PURPOSE: To describe the CT findings of orbital cellulitis due to sinusitis. METHODS: The records and CT scans of 45 consecutive patients with orbital cellulitis due to sinusitis treated at the Hospital of the Medical School of Ribeirão Preto were analyzed by a radiologist and two orbital surgeons. RESULTS: Three major types of CT changes were observed: diffuse fat infiltration, subperiosteal abscess and orbital abscess. Diffuse fat infiltration (characterized by an increased density of the e...

  17. Carcinoma a cellule basali: l'esperienza della dermatologia dell'Universita' di Bologna dal 1990 al 2014

    OpenAIRE

    Gaspari, Valeria

    2015-01-01

    Il carcinoma a cellule basali (BCC) costituisce l'80 peercento dei tumori cutanei non-melanoma, rappresentando dunque il tumore maligno della cute più frequente nella popolazione generale. Tuttavia, non esistono ad oggi studi epidemiologici ampi ed approfonditi condotti su scala nazionale su questo tipo di neoplasia, poichè i tumori cutanei non-melanoma sono esclusi dal registro statistico dei tumori. A tale scopo presso la Dermatologia dell'Università di Bologna sono stati raccolti di tut...

  18. Juvenile cellulitis in a puppy – case reports
    Celulite juvenil canina – relato de casos

    OpenAIRE

    Carlos Eduardo Fonseca-Alves; Aline Gonçalves Correa; Hérika Xavier da Costa; Fabiana Elias; Helvécio Leal Santos Junior; Sabrina dos Santos Costa; Sabryna Gouveia Calazans

    2012-01-01

    Juvenile cellulitis or juvenile sterile granulomatous lymphadenitis is a rare disorder that affects puppies between three weeks to six months years old. Clinical signs include alopecia, edema, papules, pustules and crusts especially on eyelids. Definitive diagnosis requires cytological and histological evaluation and early and aggressive therapy is recommended, once scars after recovery can be severe .The choice treatment is the high dose of corticosteroids use such as prednisone. Three anima...

  19. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    Directory of Open Access Journals (Sweden)

    Juan S. Lasa

    2012-08-01

    Full Text Available La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB. Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celulitis. Se analizaron retrospectivamente los registros clínicos de los pacientes con este diagnóstico al ingreso entre junio de 2007 y marzo de 2010. Se evaluaron los datos poblacionales, presencia de comorbilidades, y resultados de los cultivos. En ese período, se internaron 140 pacientes con diagnóstico de celulitis y a todos ellos se les realizó hemocultivo y cultivos de PPB. Setenta y cuatro eran varones (52.8%. La edad promedio: 47.5 ± 19.7 años (rango 16-94. El 40% tuvo cultivos positivos de PPB, en los que el Staphylococcus aureus meticilino resistente (SAMR fue el germen más frecuentemente aislado (35.7%; la prevalencia de bacteriemia fue del 8.6%, en donde el germen más frecuente fue Streptoccocus Beta hemolítico, grupo G (33% del total de hemocultivos positivos. La bacteriemia se asoció significativamente a mayor estadía hospitalaria (10.5 ± 8.9 vs. 4.9 ± 6, p = 0.004. Se asoció con mayor riesgo de hemocultivo positivo a ser diabético, tener cultivo de PPB positivo, consumo de alcohol y/o enfermedad pulmonar obstructiva crónica.Cellulitis is an acute inflammation of dermis and subcutaneous tissue, usually complicating wounds, ulcers, or dermatosis. Even though in these cases it is recommended to perform culture from skin and soft tissue samples, the utility of blood cultures remains controversial due to the low frequency of positive results. Here we report the prevalence of bacteremia in patients with cellulitis admitted in our

  20. Juvenile cellulitis in a puppy – case reportsCelulite juvenil canina – relato de casos

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Fonseca-Alves

    2012-08-01

    Full Text Available Juvenile cellulitis or juvenile sterile granulomatous lymphadenitis is a rare disorder that affects puppies between three weeks to six months years old. Clinical signs include alopecia, edema, papules, pustules and crusts especially on eyelids. Definitive diagnosis requires cytological and histological evaluation and early and aggressive therapy is recommended, once scars after recovery can be severe .The choice treatment is the high dose of corticosteroids use such as prednisone. Three animals of canine species were attended at the Veterinary Hospital Clinical Small Animal Service presenting different clinical signs. Hemogram, skin lesions and submandibular lymph nodes cytological examination was collected and analyzed. The treatment was instituted, using cephalexin (22mg/kg, twice daily up to control of secondary bacterial infection, and prednisone (2mg/kg, once a day until clinical resolution. Complete cure was obtained at the end of treatment. The aim of this work is to report three clinical cases of juvenile cellulitis in dogs. A celulite juvenil ou linfadenite granulomatosa estéril juvenil, é um distúrbio raro que acomete filhotes com idade entre três semanas a seis meses. Os sinais clínicos incluem alopecia, edema, pápulas, pústulas e crostas especialmente em pálpebras. O diagnóstico definitivo requer exames citológico e histopatológico e a terapia precoce e agressiva é preconizada, pois as cicatrizes após recuperação podem ser graves. O tratamento de escolha consiste no uso de altas doses dos glicocorticoides, como prednisona. Foram atendidos no Hospital Veterinário, três animais da espécie canina, apresentando sinais clínicos variados. Foram realizados hemograma, exame citológico das lesões de pele e dos linfonodos submandibulares. O tratamento foi instituído, utilizando-se cefalexina na dose de 22 mg/kg, duas vezes ao dia, até controle de infecção bacteriana secundária e prednisona na dose de 2mg/kg, uma vez

  1. Occlusion intestinale aigue révélant un lymphome T digestif associé à la maladie cœliaque, à propos d'un cas

    Science.gov (United States)

    Garba, Abdoul Aziz; Adamou, Harissou; Magagi, Ibrahim Amadou; Brah, Souleymane; Habou, Oumarou

    2016-01-01

    Le lymphome T intestinal associé à une entéropathie ou Enteropathy associated T-cell lymphoma (EATL), est une complication rare de la maladie cœliaque (MC). Nous rapportons l'observation d'un lymphome T associée à une MC révélé par une occlusion intestinale aigue. Une patiente maghrébine de 38 ans, aux antécédents de stérilité et de douleurs abdominales chroniques, était admise en urgence pour occlusion intestinale aigue. L'intervention chirurgicale retrouvait une tumeur au dépend du grêle avec des adénopathies mésentériques. L'histologie et l'immunohistochimie de la pièce opératoire objectivait un lymphome T digestif CD3+ et le bilan immunologique de la maladie cœliaque était positif. Le diagnostic d'EATL était ainsi retenu. La patiente était mise sous chimiothérapie (CHOEP) et régime sans gluten avec une réponse complète au traitement. L'EATL est une complication rare de la MC qui peut être révélée par une occlusion intestinale. Son pronostic peut être amélioré par une prise en charge précoce associant chirurgie et chimiothérapie. Sa prévention passe par un diagnostic précoce de la MC et un régime sans gluten. PMID:27217874

  2. Mecanismos moleculares implicados en el efecto protector de los polifenoles de la dieta frente al estrés oxidativo y la inflamación: estudio en células intestinales y animales de experimentación

    OpenAIRE

    Rodríguez Ramiro, Ildefonso

    2012-01-01

    El estrés oxidativo parece ser una de las causas implicadas en el origen de numerosas patologías y enfermedades intestinales. Los desequilibrios redox producidos en la mucosa intestinal pueden dar lugar a daños oxidativos y a una disfunción en las vías de señalización celular iniciando diversos procesos patológicos. En los últimos años la prevención nutricional de las enfermedades ha empezado a tomar una gran importancia. Así, ha surgido un gran interés por investigar los efectos biológ...

  3. Intestinal parasitic infections in human immunodeficiency virus (HIV) positive individuals in Southeastern Venezuela Infecciones parasitarias intestinales en individuos positivos con el virus de la inmunodeficiencia humana (VIH) en el Sureste de Venezuela

    OpenAIRE

    Alejandro Caraballo; Indhira Orozco; Liliana Muñoz

    2001-01-01

    Un estudio fue realizado en relación a establecer la presencia de parásitos intestinales en 35 pacientes infectados con el virus de la inmunodeficiencia humana (VIH), desde julio 1997 a octubre 1998, admitidos en el Hospital Universitario "Ruiz y Páez" de Ciudad Bolívar, Venezuela. Parásitos fueron detectados en heces usando diversos métodos para la investigación de protozoos y hemintos, concentración éter-formalina, tinción de Kinyoung y tricromico. Edad, sexo, estado clínico de la infección...

  4. Efecto del suero de leche como complemento de la dieta sobre el crecimiento de las vellosidades intestinales y el peso de lechones en la etapa de 6 a 20 kg

    OpenAIRE

    Rosa Elena Pérez Sánchez; Manuel López Rodríguez; Erick Chapaev Bautista Guzmán; Antonio García Valladares; Rafael María Román Bravo; Ruy Ortiz Rodríguez

    2014-01-01

    Esta investigación fue realizada en las instalaciones del Sector Porcino de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Michoacana de San Nicolás de Hidalgo, México, con el propósito de evaluar el efecto de la suplementación con suero de leche (SL), sobre el crecimiento de las Vellosidades Intestinales (LVI) en esta especie y el crecimiento corporal y variables relacionadas. Se utilizaron treinta lechones homogéneos Landrace-Duroc x Pietrain, con un promedio de 5,49 ± 1,...

  5. Cryptococcosis mimicking cutaneous cellulitis in a patient suffering from rheumatoid arthritis: a case report

    Directory of Open Access Journals (Sweden)

    Probst Corina

    2010-08-01

    Full Text Available Abstract Background Cryptococcus neoformans is an encapsulated yeast and the most frequent cryptococcal species found in humans. Cryptococcosis is considered an opportunistic infection as it affects mainly immunosuppressed individuals. In humans, C. neoformans causes three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and wound or cutaneous cryptococcosis. Case Presentation An 81-year-old woman developed severe necrotizing cellulitis on her left arm without any preceding injury. The patient had been treated with systemic corticosteroids over twenty years for rheumatoid arthritis (RA. Skin biopsies of the wound area were initially interpreted as cutaneous vasculitis of unknown etiology. However, periodic acid Schiff staining and smear analysis later revealed structures consistent with Cryptococcus neoformans, and the infection was subsequently confirmed by culture. After the initiation of therapy with fluconazole 400 mg per day the general condition and the skin ulcers improved rapidly and the patient was discharged to a rehabilitation facility. Subsequently surgical debridement and skin grafting were performed. Conclusions Opportunistic infections such as cryptococcosis can clinically and histologically mimic cutaneous vasculitis and have to be investigated rigorously as a differential diagnosis in immunosuppressed patients.

  6. Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.

    Science.gov (United States)

    Hau, Estelle; Bouaziz, Jean-David; Lafaurie, Matthieu; Saussine, Anne; Masson, Vincent; Rausky, Jonathan; Bagot, Martine; Guibal, Fabien

    2016-03-01

    Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement. PMID:27023094

  7. A rare case of orbital cellulitis followed by therapeutic(orthodontic) extraction.

    Science.gov (United States)

    Srinivasa Prasad, B; Govardhan, T

    2011-09-01

    We report a rare case of orbital cellulitis occurring secondary to a dental infection followed by therapeutic (orthodontic) extraction. A 16 year old female patient presented to the dental office with a left orbital proptosis for the past 4 days. PNS view, CT scan revealed an abscess in relation to medial, lateral superior inferior walls of the orbit associated with naso ethmoidal and left maxillary sinus. Through nasal endoscopy, middle meatus antrostomy and ethmoidectomy was performed for the drainage of pus from the orbit, ethmoid and maxillary sinus under general anesthesia. Immediately regression of orbital swelling was noticed. Eyeball movements improved. Epiphora reduced and proptosis declined. With the advent of higher antibiotics, orbital infection rarely occurs secondary to dental causes except in a very few cases. Complete elimination of pus from orbital cavity, para nasal air sinuses and appropriate antibiotic coverage at the earliest forms the mainstay of treatment. The nasal endoscopic approach with orbital decompression is the most acceptable atrumatic, cosmetic and functional procedure. PMID:22942598

  8. A case of cellulitis of the hands caused by a predatory bird attack

    Institute of Scientific and Technical Information of China (English)

    M Adil Abbas Khan; Mohammed Farid; Zain A Sobani; Syed Nadir Ali; Huzaifa Malick; Maryam Baqir; Hasanat Sharif; M Asim Beg

    2011-01-01

    Many species have been drastically affected by rapid urbanization. Harris's hawks from their natural habitat of open spaces and a supply of rodents, lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub- and peri-urban areas. Specific areas include playgrounds, parks and school courtyards. The migration of this predatory species into these areas poses a risk to individuals, and especially the children are often attacked by claws, talons and beaks intentionally or as collateral damage while attacking rodent prey. In addition, the diverse micro-organisms harbored in the beaks and talons can result in wound infections, presenting a challenge to clinical management. Here we would like to present a case of an80-year-old man with cellulitis of both hands after sustaining minor injuries from the talons of a Harris's hawk and review the management options. We would also like to draw attention to the matter that, even though previously a rarity, more cases of injuries caused by birds of prey may be seen in hospital settings.

  9. Die epitheliale Barriere als Zielstruktur pathogener und probiotischer Bakterien

    OpenAIRE

    Hering, Nina A.

    2011-01-01

    Yersinia enterocolitica is a common cause of acute gastroenteritis. In order to clarify the mechanisms leading to diarrhea and barrier dysfunction the pathomechanisms of this infection were studied in detail. Exposure of human colonic HT-29/B6 cells to Y. enterocolitica resulted in a decrease in transepithelial resistance (Rt, TER) with a parallel increase in mannitol (182 Da) and fluorescein (332 Da) permeability. Active ion transport measured as short circuit current was unchanged. The Y. e...

  10. Estado nutricional y parasitosis intestinales en niños residentes en zonas urbana, periurbana y rural del partido de Brandsen (Buenos Aires, Argentina

    Directory of Open Access Journals (Sweden)

    Cesani Rossi, María Florencia

    2007-01-01

    Full Text Available El presente estudio tuvo como objeto analizar el estado nutricional y las parasitosis intestinales en niños de 3 a 6 años de edad, residentes en zonas urbanas (U, periurbanas (PU y rurales (R del partido de Brandsen. La muestra quedó constituida por 600 niños (302 varones y 298 mujeres. Los valores P85#P95 definieron sobrepeso y >P95 obesidad. Se tomaron muestras de materia fecal seriada y escobillado anal que fueron analizadas mediante técnicas de concentración por sedimentación (Ritchie y flotación (Willis. Los datos fueron asociados con las características socioambientales de cada zona. PU presentó prevalencias de baja talla para la edad y parasitosis significativamente mayores que U (p<0.01. Se registraron 7 especies parásitas en U, 8 en PU y 4 en R, siendo Enterobius vermicularis, Blastocystis hominis y Giardia lamblia las especies más abundantes. También el poliparasitismo fue mayor en PU. Aunque el sobrepeso y la obesidad fueron elevados en las tres zonas, las mayores prevalencias se registraron en PU y R respecto de U (p<0.01. La coexistencia de desnutrición y sobrepeso-obesidad, podría vincularse con los cambios experimentados en las costumbres alimentarias y los modos de vida de estas poblaciones en el contexto de la transición nutricional. La zona periurbana presenta las peores condiciones socio-ambientales para el crecimiento y la salud de los niños en edad preescolar.

  11. Implications and applications of systematic reviews for evidence-based dentistry and comparative effectiveness research: A sample study on antibiotics for oro-facial cellulitis treatment

    Directory of Open Access Journals (Sweden)

    Quyen Bach

    2015-01-01

    Full Text Available Introduction: Comparative effectiveness and efficacy research for analysis and practice (CEERAP was performed to assess the effects of penicillin-based versus erythromycin-based antibiotic treatments in patients with skin and soft tissue infections (SSTIs including cellulitis, impetigo, and erysipelas. Because SSTIs, especially orofacial cellulitis, are volatile infectious diseases of a life-threatening nature, research on the most efficacious remedies is necessary. Methods: The stringent bibliome yielded three systematic reviews, which were examined for quality of research synthesis protocol and clinical relevance. Results: The sample size of three, rendered the statistical analyses and cumulative meta-analysis problematic. Conclusion: The systematic review outlined here should aid in increasing clinical awareness, improving patient health literacy, and promoting consensus of the best evidence base (BEB to mitigate the threat of sepsis and potential death caused by cellulitis infections.

  12. Rôle de la signalisation TPO dans la réparation de l'ADN des cellules souches hématopoïétiques

    OpenAIRE

    De Lacoste De Laval, Bérengère

    2013-01-01

    A l'origine de l'hématopoïèse se trouve les cellules souches hématopoïétiques (CSH). Elles constituent un pool de cellules rares présentes dans la moelle osseuse aux niveaux de zones particulières de l'os appelées niche. Les cellules de la niche produisent des cytokines, telles que la thrombopoïétine (TPO), qui régulent les CSH en contrôlant leur quiescence et leur auto-renouvellement. Peu de choses sont connues sur les mécanismes mis en place par la CSH et son environnement pour faire face a...

  13. Etude théorique des cellules solaires PV organiques: structure réseau interpénétré polymère conjugué-fullerène et cellules Graetzel

    OpenAIRE

    Zakaria, BOUZID

    2014-01-01

    Le photovoltaïque est aujourd'hui une technologie d'énergie renouvelable en plein essor. La croissance du marché a été comprise entre 15% et 20% durant la dernière décennie. Malgré le développement des matériaux et des méthodes de fabrication fortement soutenus par la croissance de l'industrie des semi-conducteurs, le coût des cellules solaires est resté élevé. Cependant, de nouveaux matériaux photovoltaïques ont été développés durant les dernières années, cela pourrait bien ouvri...

  14. CF findings of bowel infarction in 56 surgical patients, 5 of whom with reversible ischemia; Aspetti alla tomografia computerizzata dell'infarto intestinale. 56 pazienti sottoposti a interventi chirurgico di cui 5 con ischemia mesenterica reversibile.

    Energy Technology Data Exchange (ETDEWEB)

    Salzano, A.; De Rosa, A.; Carbone, M.; Ginolfi, F.; Rossi, E.; Amodio, F. [Naples Univ. Federico 2. (Italy). Ist. di Scienze Radiologiche; Muto, M.; Tuccillo, M. [Azienda Sanitaria di Rilievo Nazionale A. Cardarelli, Naples (Italy). Servizio di Neuroradiologia

    1999-04-01

    Bowel infarction is a rare and typical condition of the elderly; despite improvements in diagnostic imaging and vascular surgery, bowel infarction remains a major cause of acute abdomen, with mortality rates ranging 70-80%. Diagnosis on often late because clinical signs, laboratory data and radiologic findings are a specific. The authors investigated radiographic and particular CT patterns of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. CT is more sensitive than radiography and does not exhibit the limitations of angiography (i.e., invasiveness, radiation exposure and complex organization). Therefore CT can presently be considered the method of choice in patients with suspected bowel infarction. [Italian] L'infarto intestinale rappresenta una malattia rara e tipica del soggeto anziano; nonostante il notevole perfezionamento delle tecniche di diagnostica per immagini e il progresso della chirurgia vascolare, rimane ancora oggi una delle piu' temibili condizioni di addome acuto, con mortalita' superiore al 70-80%. Il riconoscimento diagnostico e' tardivo per l'aspecificita' dei dati di laboratorio, dei segni clinici e degli esami radiologici. La TC presenta maggiore afficacia diagnostica rispetto all'esame radiografico diretto e non ha limiti che caratterizzano l'angiografia, quali l'invasivita', radioesposizione e complessita' organizzativa: attualmente la metodica TC puo' essere indicata come indagine di scelta in pazienti con sospetto infarto intestinale.

  15. Cellulitis-like symptoms manifested by bone metastasis of lung cancer in a patient living with human immunodeficiency virus.

    Science.gov (United States)

    Kashima, Jumpei; Okuma, Yusuke; Watanabe, Kageaki; Ajisawa, Atushi; Hishima, Tsunekazu

    2016-09-01

    Human immunodeficiency virus (HIV)-infected patients are at a high risk of cancer compared with the general population. As the use of antiretroviral therapy (ART) has increased, non-AIDS-defining cancers have also increased in the past decade. A 61-year-old man with HIV infection on ART developed a painful, erythematous and oedematous lower left leg and an associated fever. He was initially treated with antibiotics for cellulitis but there was no improvement, which warranted further investigation. A translucent lesion was found by X-ray imaging and bone scintigraphy showed bone metastasis from a primary adenocarcinoma of the lung, documented by chest computed tomography and an axillary lymph node biopsy. The patient died three months after the diagnosis despite undergoing chemotherapy. This case demonstrates that physicians should consider metastatic malignancies as a differential diagnoses for diverse skin changes in HIV-infected patients. PMID:26404113

  16. Tratamiento cognitivo-conductual protocolizado en grupo de las enfermedades inflamatorias intestinales Protocolized cognitive-behavioural group therapy for inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    M. A. Díaz Sibaja

    2007-10-01

    Full Text Available Introducción: los pacientes con enfermedades inflamatorias intestinales presentan una mayor tasa de alteraciones psicopatológicas que la población normal, predominantemente ansiedad y depresión. Objetivo: el principal objetivo de este estudio fue diseñar, poner en práctica y validar un programa de tratamiento psicológico protocolizado, basado en el modelo de competencias y con una metodología psicoeducativa, en el que se incluyeron los siguientes módulos de intervención: información de la enfermedad, modelo de afrontamiento, solución de problemas, técnicas de relajación, entrenamiento en habilidades sociales, técnicas de distracción y técnicas de reestructuración cognitiva. Todas estás técnicas fueron adaptadas a la problemática característica de la enfermedad inflamatoria intestinal. Método: la muestra estuvo constituida por 57 pacientes diagnosticados de enfermedad inflamatoria intestinal de la Asociación de Enfermos de Crohn y Colitis Ulcerosa de España. La muestra se distribuyó aleatoriamente en dos grupos experimentales, 33 formaron parte del programa de tratamiento en grupo y 24 fueron asignados al grupo control en lista de espera. Las variables emocionales medidas fueron: ansiedad y depresión. Resultados: los resultados reflejaron una mejoría clínica y estadísticamente significativa en las variables de ansiedad (p Introduction: patients affected by inflammatory bowel disease have a high rate of psychiatric disorders such as depression and anxiety. Objective: the main goal of this study was to design, to put into practice, and to validate a protocolized psychological treatment program based on the coping model, and a psycho-educational methodology in which the following intervention modules were included- illness information, coping model, problem solving techniques, relaxation, social skill training, distraction, and cognitive restructuring techniques. All these techniques were adapted to the characteristic

  17. Absorption intestinale des vitamines liposolubles

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    Reboul Emmanuelle

    2011-03-01

    Full Text Available The molecular mechanisms of fat-soluble vitamin intestinal absorption remain partly unknown, despite the fact that a better understanding of this process would certainly allow to improve their bioavailability. If their digestion-absorption process follows the fate of lipids globally, the recent discovery of membranes proteins involved in their absorption questioned the established dogmas. These new data should be taken into account to avoid dietary or drug interactions that may limit some fatsoluble vitamin bioavailability.

  18. Absorption intestinale des vitamines liposolubles

    OpenAIRE

    Reboul Emmanuelle

    2011-01-01

    The molecular mechanisms of fat-soluble vitamin intestinal absorption remain partly unknown, despite the fact that a better understanding of this process would certainly allow to improve their bioavailability. If their digestion-absorption process follows the fate of lipids globally, the recent discovery of membranes proteins involved in their absorption questioned the established dogmas. These new data should be taken into account to avoid dietary or drug interactions that may limit some fat...

  19. Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

    OpenAIRE

    Thomas, K.S.; Cox, N H; Savelyich, B S P; Shipley, D.; Meredith, S; A. Nunn; Reynolds, N.; Williams, H.C.; Angus, J; Bell, H.; Bourke, J.; Burge, S.; Ferguson, A.; Finlay, A.; Fulton, R

    2007-01-01

    Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study. Of these, 17 obtained full ethics and Research & Development (R&D) approval, and 15 successfully recruited patients into the study. A total of 70 participants with a diagnosis of cellulitis of the leg were enrolled over a 5-month period. These partici...

  20. Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

    OpenAIRE

    Thomas, Kim S.; Cox, Neil H; Savelyich, Boki SP; Shipley, Debbie; Meredith, Sarah; Nunn, Andrew; Williams, Hywel C.; Reynolds, Nick

    2007-01-01

    Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study. Of these, 17 obtained full ethics and Research & Development (R&D) approval, and 15 successfully recruited patients into the study. A total of 70 participants with a diagnosis of cellulitis of the leg were enrolled over a 5-month period. T...

  1. Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

    Directory of Open Access Journals (Sweden)

    Meredith Sarah

    2007-01-01

    Full Text Available Abstract Background This paper describes the results of a feasibility study for a randomised controlled trial (RCT. Methods Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN expressed an interest in recruiting for this study. Of these, 17 obtained full ethics and Research & Development (R&D approval, and 15 successfully recruited patients into the study. A total of 70 participants with a diagnosis of cellulitis of the leg were enrolled over a 5-month period. These participants were largely recruited from medical admissions wards, although some were identified from dermatology, orthopaedic, geriatric and general surgery wards. Data were collected on patient demographics, clinical features and willingness to take part in a future RCT. Results Despite being a relatively common condition, cellulitis patients were difficult to locate through our network of UK DCTN clinicians. This was largely because patients were rarely seen by dermatologists, and admissions were not co-ordinated centrally. In addition, the impact of the proposed exclusion criteria was high; only 26 (37% of those enrolled in the study fulfilled all of the inclusion criteria for the subsequent RCT, and were willing to be randomised to treatment. Of the 70 participants identified during the study as having cellulitis of the leg (as confirmed by a dermatologist, only 59 (84% had all 3 of the defining features of: i erythema, ii oedema, and iii warmth with acute pain/tenderness upon examination. Twenty-two (32% patients experienced a previous episode of cellulitis within the last 3 years. The median time to recurrence (estimated as the time since the most recent previous attack was 205 days (95% CI 102 to 308. Service users were generally supportive of the trial, although several expressed concerns about taking antibiotics for lengthy periods, and felt that multiple morbidity/old age would limit entry into a 3-year study. Conclusion This pilot study has been

  2. Intestinal parasitoses and environmental factors in a rural population of Argentina, 2002-2003 Parasitosis intestinales y factores ambientales en una población rural de Argentina, 2002-2003

    Directory of Open Access Journals (Sweden)

    Juan A. Basualdo

    2007-08-01

    Full Text Available We evaluate the prevalence of intestinal parasites in 504 people and the degree of association between environmental variables and parasites found in population, soil and water in a rural area of Argentina during 2002-2003. A structured survey was used to evaluate the environmental variables and fecal-human, soil and water samples were analyzed. The prevalence of parasites was 45.4%. Most prevalent protozoa were Blastocystis hominis (27.2% and Giardia lamblia (6.9%, while the most prevalent helminth was Ascaris lumbricoides (3.8%. The analyzed environmental variables showing association (p Hemos evaluado la prevalencia de parásitos intestinales en 504 personas y el grado de asociación entre las variables ambientales y los parásitos intestinales hallados en la población, el suelo y el agua de una zona rural de Argentina durante 2002-2003. Se utilizó una encuesta estructurada para relevar las variables ambientales y se examinaron muestras fecales humanas, de agua y de suelo. La prevalencia parasitaria fue de 45,4%. Los protozoos prevalentes fueron Blastocystis hominis (27,2% y Giardia lamblia (6,9%, mientras que el helminto mas prevalente fue Ascaris lumbricoides (3,8%. Las variables ambientales analizadas que mostraron asociación (p < 0,05 con la presencia de parásitos en la población fueron: casa de cartón-chapa o de madera con piso de tierra, bomba de agua domiciliaria o comunitaria, canilla fuera de la casa o pública y pozo ciego o letrina. Elementos parasitarios fueron hallados en el 82,3% de las muestras de suelo y en el 84,2% de las muestras de agua. En ambas muestras fueron hallados parásitos que también se encontraron en las personas. En este trabajo hemos hallado deficientes condiciones sanitarias asociadas con la presencia de parásitos en las personas y hemos evidenciado que el suelo y el agua contaminada fueron la fuente de esos parasitos.

  3. Cancer bronchique à petites cellules et grossesse: à propos d'un cas avec revue de la literature

    Science.gov (United States)

    Safini, Fatima; Jjouhadi, Hassan; Chehal, Asmaa; Mernissi, Farida; Wilfried, Akpoo; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2016-01-01

    Le cancer broncho-pulmonaire (CBP) de la femme enceinte est une entité rare, d’évolution péjorative. Cette situation devient de plus en plus fréquente, du fait de l'augmentation du tabagisme chez la femme. La transmission tumorale trans-placentaire avec atteinte fœtale est décrite surtout chez les femmes non traitées. Le traitement est multidisciplinaire et n'est pas bien codifié. Nous rapportons le cas d'une patiente de 23 ans chez qui le diagnostic d'un carcinome bronchique à petites cellules a été fait au cours de sa grossesse. Elle avait bénéficié d'une chimiothérapie pendant la grossesse, bien tolérée. L’évaluation radiologique a objectivé une stabilisation du processus pulmonaire. Le traitement a été complété par une association radio-chimiothérapie concomitante après l'accouchement. PMID:27279957

  4. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba Training for diagnosis of intestinal parasites in the national laboratory system in Cuba

    Directory of Open Access Journals (Sweden)

    Fidel Angel Núñez

    2001-06-01

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (pA national training project in the diagnosis of intestinal parasites was conducted in 1997. An initial national course was followed respectively by courses in the Central, Eastern, and Western Provinces. Our results showed that Cryptosporidium parvum, Cyclospora cayetanensis, and leukocytes showed a significantly lower percentage of errors after the training than before (p 0.05. Furthermore, when comparing scores before and after training, a significant increase in median scores appeared in the Central Provinces (p < 0.05, Western Provinces (p < 0.01, and in the entire series (p < 0.01. The results showed the effectiveness of this intervention; these periodic mandatory training courses should be developed together with national programs for quality assessment in Parasitology.

  5. Synthèse et caractérisation de cellules pour pile à combustible de type IT-SOFC utilisée en tant que système APU dans les transports

    OpenAIRE

    Sivasankaran, Visweshwar,

    2014-01-01

    La fabrication de cellules de piles à combustible IT-SOFC de large dimension par un nouveau procédé simple et peu coûteux est présentée dans ce manuscrit. L’optimisation de ce nouveau procédé en regard de l’utilisation d’agents de porosité, d’épaisseur de couches et de température de frittage a été réalisée. Les résultats des tests électrochimiques sur des cellules de surface active 10 cm2 réalisés dans le dispositif Fiaxell semi-ouvert ont été détaillés pour différentes cellules. Des tests d...

  6. Computed tomographic patterns of orbital cellulitis due to sinusitis Padrões tomográficos de celulite orbitária secundária à sinusite

    Directory of Open Access Journals (Sweden)

    Filipe José Pereira

    2006-08-01

    Full Text Available PURPOSE: To describe the CT findings of orbital cellulitis due to sinusitis. METHODS: The records and CT scans of 45 consecutive patients with orbital cellulitis due to sinusitis treated at the Hospital of the Medical School of Ribeirão Preto were analyzed by a radiologist and two orbital surgeons. RESULTS: Three major types of CT changes were observed: diffuse fat infiltration, subperiosteal abscess and orbital abscess. Diffuse fat infiltration (characterized by an increased density of the extra- or intraconal fat was seen in 11 patients (24.44%. A subperiosteal abscess was diagnosed in 28 patients (62.23%. A surgically proved orbital abscess was detected in 6 patients (13.33%. CONCLUSIONS: In all cases of orbital cellulitis due to sinusitis intraorbital changes can be detected by CT scans either as a diffuse infiltration of the orbital fat or as a detachment of the periorbita (subperiosteal abscess or a true orbital abscess. Category I of Chandler orbital cellulitis classification (inflammatory edema must be understood as a stage of a process that is already happening within the orbit and, as the term "preseptal cellulitis" means a palpebral infection, this designation should not be used to stage orbital cellulitis.OBJETIVO: Descrever os achados tomográficos em celulites orbitárias secundárias à sinusite. MÉTODOS: Os prontuários e filmes tomográficos de 45 pacientes consecutivos com celulite orbitária secundária à sinusite tratados no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto foram analisados por um radiologista e dois cirurgiões de órbita. RESULTADOS: Três principais tipos de alterações tomográficas foram observadas: infiltração difusa da gordura, abscesso subperiósteo e abscesso orbitário. Infiltração difusa da gordura (caracterizada por aumento da densidade da gordura extra ou intraconal foi vista em 11 pacientes (24,44%. Abscesso subperiósteo foi diagnosticado em 28 pacientes (62

  7. Étude de transfert des films minces de silicium monocristallin dans la réalisation de cellule solaire à faible budget thermique

    OpenAIRE

    BENCHERRAT, Abdennebi

    2012-01-01

    La production de l‟électricité à partir de l‟énergie solaire est devenue très importante ce qui conduit à développer les cellules photovoltaïques et améliorer leurs rendements. Le silicium est le matériau le plus largement utilisé pour la conversion photovoltaïque. Cependant, le coût du silicium constitue près de 50 % du prix de revient d'un module photovoltaïque. La réduction de consommation de matériau silicium est une solution très importante.

  8. Studio dei polimorfismi genici degli antigeni minori di istocompatibilità e GvHD/GvL nel trapianto allogenico di cellule staminali emopoietiche

    OpenAIRE

    Cattina, Federica

    2013-01-01

    L'outcome dei pazienti sottoposti a trapianto allogenico di cellule staminali emopoietiche è fortemente influenzato da graft versus leukemia (GvL) e graft versus host disease (GvHD) che sono mediate, almeno in parte, dagli antigeni minori di istocompatibilità (mHAgs). In letteratura sono stati identificati 26 mHAgs che sono stati correlati a GvHD/GvL con risultati incompleti e in alcuni casi contrastanti; inoltre manca una metodica che sia in grado di genotipizzare contemporaneamente un p...

  9. Films minces à base de Si nanostructuré pour des cellules photovoltaïques de 3ème génération.

    OpenAIRE

    Nalini, R.P.

    2012-01-01

    L'association du concept de troisième génération de cellules solaires et de la technologie de fabrication des films minces ouvre la voie à l'élaboration de matériaux entrant dans le cadre des énergies renouvelables. Les effets de confinement quantiques observés dans les nanostructures de silicium sont exploités pour une intégration dans des dispositifs du type cellule tandem tout-silicium. Cette thèse vise à comprendre la formation de nanoparticules de silicium dans deux types de ...

  10. The role of 99mTc-labelled stannous colloid white blood cells scanning in the evaluation of and differentiation between cellulitis and osteomyelitis

    International Nuclear Information System (INIS)

    Full text: Sequential 99mTc-MDP and 67Ga-citrate scanning have been extensively used in the evaluation of infection. 99mTc-labelled stannous colloid white blood cell (Tc-WBC) is not widely reported. A prospective study was undertaken in 92 patients to assess Tc-WBC and Tc-MDP scanning in this clinical application. Labelling efficiency (LE) was calculated with a mean ± SD of 94 ± 4.8 %. Patients (6) who were treated with gentamycin had an LE ± SD of 70 ± 9%. Twenty six patients treated as osteomyelitis had congruent abnormalities on Tc-WBC and Tc-MDP scans. Twenty one patients treated as cellulitis had abnormalities demonstrated on Tc-WBC but not on Tc-MDP scans. Tc-WBC appeared to define areas of inflammation of bone and soft-tissue in the hands or feet more distinctly than Tc-MDP. Fourteen patients had progress Tc-WBC scans 4-6 weeks following antibiotic treatment. Changes in scan appearances seemed to mirror the clinical course of the patients. Tc-WBC and Tc-MDP scans were useful complementary studies in the diagnosis, evaluation and assessment of treatment in patients with cellulitis and osteomyelitis

  11. Prevalence of intestinal helminths in cats in Quindío, Colombia Prevalencia de helmintos intestinales en gatos domésticos del departamento del Quindío, Colombia

    Directory of Open Access Journals (Sweden)

    Diana Marcela Echeverry

    2012-03-01

    Full Text Available

    Introduction. Diseases caused by helminths are widely distributed in the world and many of them are considered zoonoses in which pets play a major role in transmission to humans.
    Objective. To determine the prevalence of intestinal helminths in cats in Quindío.
    Materials and methods. 121 cats were studied in Quindío; data as sex, age and body condition were recorded. Fecal samples were collected and processed using the modified Ritchie and modified Kato-Katz techniques to determine the presence of intestinal helminths.
    Results. Of the 121 cats, 42.14%, (95%CI: 33.35-50.94 and 45.45% (95%CI: 36.58-54.32 were parasitized with at least one adult helminth species as evidenced by the presence of eggs in their fecal samples, using the Ritchie and Kato-Katz techniques, respectively. Toxocara cati was the most prevalent parasite (Ritchie: 37.2%, Kato-Katz: 43%, followed by Ancylostoma spp. (Ritchie: 7.43%, Kato-Katz: 5.78% and Aelurostrongylus abstrusus (Ritchie:0.82%. 65 cats (53.71% were females and 56 (46.28% males; the prevalence of infection was similar in both sexes. The cats older than 4 years had the highest prevalence (81.8% followed by those aged 1 to 4 years (48.8% and by those under 1 year (28.6%. The majority of cats, 77.68%, were found to be in good body condition and this group had the lowest frequency of intestinal helminthes with both techniques.
    Conclusion. The prevalence of intestinal helminths in domestic cats in the department of Quindío was 43.8%; it is necessary to establish surveillance and prevention programs in the human and feline populations.

     

    Introducción. Las enfermedades producidas por helmintos están ampliamente distribuidas en el mundo y muchas de ellas se consideran zoonosis. Los animales de compañía cumplen un papel trascendental dentro de la transmisión a los humanos.
    Objetivo. Determinar la prevalencia de helmintos intestinales en gatos del departamento del Quind

  12. What Is Cellulitis?

    Science.gov (United States)

    ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics Center ...

  13. Cellulitis and Erysipelas

    Science.gov (United States)

    ... long-term) swelling of your arms or legs (lymphedema). Diagnosis Your healthcare provider may take a sample or culture from your skin lesions to identify the bacteria causing infection. He or she may also recover the bacteria from your blood. Treatment Depending on how severe the infection is, your ...

  14. Etude et réalisation par coulage en bande et co-frittage de cellules de pile à combustible à oxydes solides

    OpenAIRE

    Grosjean, Arnaud

    2004-01-01

    L'introduction de nouveaux moyens de production d'énergie sur le marché dépend en partie de leur compétitivité. Le développement à bas coût d'un procédé de réalisation de cellules de piles à combustible à oxyde solide (SOFC), sujet de cette étude, s'inscrit dans une telle dynamique. Dans le cahier des charges défini au préalable, ont été fixés la méthode de mise en forme, -le coulage en bande-, ainsi que les matériaux, -la zircone yttriée, le nickel et le manganite de lanthane dopé au stronti...

  15. Modifications mécaniques et biologiques induites dans des cellules en culture par application locale d'une force contrôlée

    OpenAIRE

    Icard Arcizet, Delphine

    2007-01-01

    Les propriétés mécaniques des cellules adhérentes ont une importance capitale pour l'ensemble de leurs fonctions : division, migration, différenciation, etc. De plus, on sait désormais qu'elles sont très sensibles aux caractéristiques mécaniques de leur substrat, auquel elles sont ancrées par l'intermédiaire des intégrines. Ces récepteurs transmembranaires lient indirectement le cytosquelette d'actine intracellulaire aux protéines de la matrice extracellulaire.Nous avons conçu un dispositif d...

  16. Etude de la réponse immunitaire T au cours de l'artérite à cellules géantes (Maladie de Horton)

    OpenAIRE

    Samson, Maxime

    2014-01-01

    Ce travail de thèse a été axé sur l’étude de la réponse immunitaire T chez des patients atteints d’artérite à cellules géantes (ACG) et de pseudo-polyarthrite rhizomélique (PPR). Plusieurs études cliniques successives interrégionales ont permis d’inclure de nombreux patients (57 ACG et 27 PPR) des Centres Hospitaliers (CH) Universitaires et des CH de l’interrégion Est. Les échantillons sanguins ont été étudiés dans le laboratoire de l’unité INSERM U1098. Tout d’abord, nous avons confirmé l’im...

  17. Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

    Directory of Open Access Journals (Sweden)

    Ledina Dragan

    2012-11-01

    Full Text Available Abstract Introduction Campylobacter is an important causative agent of intestinal infections in humans. Bacteremia is detected in less than 1% of patients, mainly in immunocompromised patients and in extreme age groups. Cellulitis is a relatively common manifestation of Campylobacter infection, but concomitant bacteremia is a rare event. Infections of the pacemaker area are caused primarily by staphylococci, followed by fungi, streptococci and Gram-negative rods. To the best of our knowledge, this is the first case report of pacemaker pocket infection and bacteremia caused by Campylobacter fetus. Case presentation A 72-year-old Croatian Caucasian man with myelodysplasia, impaired fasting glucose levels and a recently implanted permanent pacemaker was admitted to hospital after six days of fever, development of red swelling of the pacemaker pocket area and worsening of his general condition. No antibiotic therapy was introduced in the outpatient setting. He denied any recent gastrointestinal disturbances. With the exception of an elevated leukocyte count, erythrocyte sedimentation rate, and C-reactive protein and blood glucose levels, other laboratory findings were normal. Treatment with vancomycin plus netilmicin was introduced, and a surgical incision with drainage of the pacemaker pocket was performed. The entire pacemaker system was removed and a new one re-implanted after 14 days of antibiotic therapy. Transesophageal echocardiography showed no pathological findings. Three subsequent blood cultures obtained on admission as well as swab culture of the incised pacemaker area revealed Campylobacter fetus; stool and pacemaker lead cultures were negative. According to the microbiological results, antibiotic therapy was changed to ciprofloxacin plus netilmicin. A clinical examination and the results of a laboratory analysis performed after two weeks of therapy were within normal limits. Conclusion Myelodysplasia, impaired fasting glucose levels

  18. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales Intestinal parasitosis in Mbyá-Guaraní populations from Misiones Province, Argentina: epidemiological and nutritional aspects

    Directory of Open Access Journals (Sweden)

    Graciela Teresa Navone

    2006-05-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p Intestinal parasite infestation in indigenous Mbyá-Guaraní communities in Misiones, Argentina, was described and associated with nutritional status and environmental and cultural factors. The results were compared with those from Takuapí, a neighboring indigenous population, and the nearest urban population, Aristóbulo del Valle. The Ritchie, Willis, and Kato Katz techniques were used to analyze the stool samples. Anthropometric parameters were analyzed and earth samples processed. From a total sample of 296 individuals analyzed in the four populations, 100 (87.7%, 63 (88.7%, 49 (96.1%, and 50 (82% were infested in Kaaguy Poty, Yvy Pytá, Takuapí, and Aristóbulo del Valle, respectively. 84% of infested individuals had multiple parasites. The 43% of the individuals presented malnutrition, and 87% of these were infested. There was an association between use of latrines and Giardia lamblia (p < 0

  19. Etude des phenomenes chimiques au contact entre le bloc cathodique et la barre collectrice d'une cellule d'electrolyse d'aluminium

    Science.gov (United States)

    Lebeuf, Martin

    La production d'aluminium est une industrie importante au Québec. Les propriétés de ce métal le vouent à de multiples usages présents et futurs dans le cadre d'une économie moderne durable. Toutefois, le procédé Hall-Héroult est très énergivore et des progrès demeurent donc nécessaires pour en diminuer les coûts financiers et environnementaux. Parmi les améliorations envisageables de la cellule d'électrolyse se trouve le contact entre la cathode et la barre collectrice, qui doit offrir une faible résistivité au passage du courant électrique. En cours d'opération de la cellule, ce contact a tendance à se dégrader, générant des pertes énergétiques significatives. Les causes de cette dégradation, pouvant provenir de phénomènes chimiques, thermiques, mécaniques et/ou électriques, demeurent mal comprises. Le but du présent projet était donc d'étudier les phénomènes chimiques se produisant au contact bloc-barre de la cellule d'électrolyse Hall-Héroult. En premier lieu, un aspect crucial à considérer est la pénétration du bain électrolytique dans la cathode, car des composés de bain atteignent éventuellement la barre collectrice et peuvent y réagir. A cet effet, une méthode novatrice a été développée afin d'étudier les cathodes et la pénétration du bain dans celles-ci à l'aide de la microtomographie à rayons X. Cette méthode rapide et efficace s'est avérée fort utile dans le projet et a un potentiel important pour l'étude future des cathodes et des phénomènes qui s'y produisent. Ensuite, une cellule d'électrolyse rectangulaire à petite échelle a été développée. Plusieurs phénomènes observés 'en industrie sur des autopsies de cellules post-opération et rapportés dans la littérature ont été reproduis avec succès à l'aide de cette cellule expérimentale. Puis, des tests sans électrolyse, ciblant l'effet du bain électrolytique sur l'acier, ont aussi été conçus et complétés afin de s

  20. Origine et développement des cellules germinales chez l'huître Crassostrea gigas : intérêt pour le contrôle de la reproduction en écloserie

    OpenAIRE

    Fabioux, Caroline

    2004-01-01

    Le renouvellement annuel de la population de cellules germinales chez l'huître creuse Crassostrea gigas est une étape clé de son cycle de reproduction. La compréhension de ces mécanismes est essentielle à la maîtrise de la reproduction contrôlée de C. gigas, indispensable pour répondre à une demande croissante des ostréiculteurs, de naissain produit en écloserie. Les objectifs de cette étude étaient de déterminer l'origine et les mécanismes de renouvellement annuel des cellules germinales de ...

  1. Prevalencia de parásitos intestinales en manipuladores de alimentos en una comunidad rural de Cojedes, Venezuela Prevalence of intestinal parasites in food handlers in a rural community in Cojedes, Venezuela

    Directory of Open Access Journals (Sweden)

    Gilberto Bastidas

    2012-12-01

    Full Text Available Introducción: las parasitosis intestinales constituyen un problema de salud pública, por la elevada prevalencia que muestran, donde los manipuladores de alimentos parasitados, se convierten en potenciales fuentes de infección, pues algunas formas parasitarias se transmiten directamente de la fuente de infección al susceptible, por vía fecal-oral. A esto se suma el incremento en el consumo de comida fuera del núcleo familiar, en residentes de zonas urbanas y rurales. El objeto es recolectar información para que las autoridades sanitarias implementen programas de salud acordes a cada región. Métodos: estudio descriptivo, de campo y transversal. Fueron 64 los manipuladores de alimentos, pero la muestra fue de 50. Se aplicó un cuestionario sobre prácticas higiénicas en la manipulación de alimentos, se determinó nivel socioeconómico y prevalencia de parasitosis por ensayos coproparasitológicos. Resultados: fueron 44 mujeres y 6 hombres; un 52% pertenecía al estrato IV; la mayoría conocía las prácticas higiénicas en la manipulación de alimentos, pero un 26% tenía alguna parasitosis intestinal; los parásitos más frecuentes fueron: E. nana (41,2% y B. hominis (38,7%; el monoparasitismo fue del 54%. Conclusión: en la presencia y frecuencia de una enfermedad parasitaria intestinal intervienen diversos factores. Por lo tanto, en manipuladores de alimentos, la educación ajustada al entorno, en buenas prácticas de higiene, es básica para prevenir la transmisión.Aim: Intestinal parasites are a public health problem due to their high prevalence. Handlers of food contaminated with parasites become potential sources of infection because some parasitic forms are transmitted directly from the source of infection to the host through the fecal-oral route. In addition, there is an increased consumption of food outside the household by residents of urban and rural areas. The objective is to collect information so that health authorities

  2. Die Rolle kutaner humaner Papillomaviren während der Entwicklung epithelialer Hauttumore

    OpenAIRE

    Köhler, Anja

    2010-01-01

    Multiple factors contribute to the development of non-melanoma skin cancer (NMSC), including UV light as the main risk factor. Another key player of skin carcinogenesis is the immune system. This correlation has been shown in studies with immunosuppressed patients such as organ transplant recipients (OTRs). They develop persistent warts in sun-exposed areas that may have the potential to progress into NMSC. Furthermore, cutaneous human papillomaviruses (cutaneous/EV HPVs) are considered to be...

  3. Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis.

    Science.gov (United States)

    Asdourian, Maria S; Skolny, Melissa N; Brunelle, Cheryl; Seward, Cara E; Salama, Laura; Taghian, Alphonse G

    2016-09-01

    Precautionary recommendations conveyed to survivors of cancer by health-care practitioners to reduce the risk of breast cancer-related lymphoedema are indispensable aspects of clinical care, yet remain unsubstantiated by high-level scientific evidence. By reviewing the literature, we identified 31 original research articles that examined whether lifestyle-associated risk factors (air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and skin infections-eg, cellulitis) increase the risk of breast cancer-related lymphoedema. Among the few studies that lend support to precautionary guidelines, most provide low-level (levels 3-5) or inconclusive evidence of an association between lymphoedema and these risk factors, and only four level 2 studies show a significant association. Skin infections and previous infection or inflammation on the ipsilateral arm were among the most clearly defined and well established risk factors for lymphoedema. The paucity of high-level evidence and the conflicting nature of the existing literature make it difficult to establish definitive predictive factors for breast cancer-related lymphoedema, which could be a considerable source of patient distress and anxiety. Along with further research into these risk factors, continued discussion regarding modification of the guidelines and adoption of a risk-adjusted approach is needed. PMID:27599144

  4. Metabolismo de isoflavonas por bacterias intestinales

    OpenAIRE

    Delgado, Susana; Guadamuro, Lucía; Flórez García, Ana Belén; Mayo Pérez, Baltasar

    2014-01-01

    Trabajo presentado en la 8ª Reunión de la Red Temática BAL (Red Española de Bacterias Lácticas), "Participación de las Bacterias Lácticas en la Salud Humana y en la Calidad Alimentaria", celebrada en San Adrián (Navarra) el 25 de junio de 2014.

  5. Cells for the examination of irradiated plutonium fuel elements - two years operation - may 1961/may 1963 (1963); Cellules pour examen d'elements combustibles au plutonium irradies - deux ans d'exploitation - mai 1961/mai 1963 (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Valentin, A. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1963-07-01

    Within the framework of the 'Rapsodie' fast reactor program, prototype plutonium fuel elements are irradiated and then examined in an {alpha} {beta} {gamma} laboratory at Saclay. This laboratory consists of five in line cells and a lead enclosure microscope. Each cell contains an {alpha} sealed removable box 4 ft 3 in. high, 4 ft 11 in. wide and 5 ft 1 in. deep, fitted with one or two magnetic transmission indirect manipulators. The boxes are contained in an {beta} {gamma} shielded enclosure whose front face is constructed of cast iron panels 21-2/3 in. thick. Nitrogen circulating in a closed loop forms the atmosphere of the boxes. This laboratory is essentially intended for metallurgical research. The functions of the various cells are as follows: transferring and packing, cutting, density measurement and cathodic etching, storage and metallography. Work on radioactive materials began in April 1961. Operational incidents have always been of a material nature only. (author) [French] Dans le cadre du projet de reacteur rapide Rapsodie, des elements combustibles prototypes au plutonium sont, apres irradiation, examines a Saclay dans un laboratoire {alpha} {beta} {gamma}. Celui-ci comprend cinq cellules en ligne et une enceinte en plomb contenant un microscope telecommande. Chaque cellule est constituee d'un caisson etanche (1, 3 m x 1, 5 m x 1, 56m) equipee d'un ou deux manipulateurs indirects a transmissions magnetiques. Les caissons sont places, dans une enceinte {beta} {gamma} dont la face avant est formee de blocs en fonte ayant 55 cm d'epaisseur. L'atmosphere des caissons est de l'azote, circulant en circuit ferme. Ce laboratoire est destine essentiellement a des recherches metallurgiques. Les fonctions des differentes cellules sont: conditionnement et transferts, tronconnage, mesure de densite et polissage ionique, stockage, metallographie. Le travail sur materiaux radioactifs a commence en avril 1961. Les incidents d

  6. Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C

    OpenAIRE

    Blanchard, Géraldine; Siegrist, Claire-Anne

    2007-01-01

    "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugué contre le sérogroupe C fait partie du plan de vaccination de routine. Chez les enfants de moins d'une année, 3 doses de vaccin induisent une montée importante des anticorps bactéricides, mais qui ne persistent pas au-delà d'une année. Les cellules B mémoires, semblent essentielles pour protéger les jeunes enfants primo-immunisés comme nourrissons. Dans...

  7. Une étude de la réponse des cellules B mémoires au vaccin polysaccharidique conjugué contre le méningocoque du sérogroupe C

    OpenAIRE

    Blanchard Rohner, Géraldine

    2006-01-01

    "Neisseraia meningitidis" est une cause importante de maladies invasives chez les enfants. En Angleterre, le vaccin polysaccharidique conjugué contre le sérogroupe C fait partie du plan de vaccination de routine. Chez les enfants de moins d'une année, 3 doses de vaccin induisent une montée importante des anticorps bactéricides, mais qui ne persistent pas au-delà d'une année. Les cellules B mémoires, semblent essentielles pour protéger les jeunes enfants primo-immunisés comme nourrissons. Dans...

  8. Glycosphingolipides et fusion virus-cellule : données actuelles montrant le rôle des micro-domaines membranaires dans le cycle d’infection du VIH-1

    Directory of Open Access Journals (Sweden)

    Hammache Djilali

    2000-09-01

    Full Text Available Depuis plusieurs années, nous étudions les mécanismes moléculaires responsables de la fusion du virus de l’immunodéficience humaine (VIH avec la membrane plasmique des cellules cibles. Ces travaux ont permis de préciser le rôle essentiel joué par les micro-domaines de glycosphingolipides au cours de la fusion virus-cellule. En particulier, nous avons pu reconstituer un complexe de fusion fonctionnel faisant intervenir les différents partenaires moléculaires de la fusion : un micro-domaine de glycosphingolipide se présentant sous la forme d’un film monomoléculaire à l’interface eau-air, le récepteur CD4 et la glycoprotéine externe de l’enveloppe du virus, la gp120. La dynamique des interactions moléculaires dans ce complexe de fusion a pu être mesurée à l’aide d’un micro-tensiomètre. Ce système expérimental pourrait permettre d’évaluer l’activité d’inhibiteurs de fusion tels que des analogues synthétiques de glycosphingolipides.

  9. Cassures double-brin de l'ADN, cassures chrosomiques et létalité des cellules humaines irradiées

    Science.gov (United States)

    Foray, N.; Arlett, C. F.; Malaise, E. P.

    1998-04-01

    DNA double-strand breaks (DSB) are the likely event which may explain the radiation-induced killing effect in mammalian cells. An overview of the litterature shows that, to the exception of a small group of human tumours, the repair defect rather than the induction rate of DSB plays the major role. However, the arguments supporting the relationship between DSB and intrinsic radiosensitivity are most often indirect. Our results dealing with intrinsic radiosensitivity, residual DNA DSB and chromosome breaks have been achieved with untransformed human fibroblasts (5 control and 18 hypersensitive cell lines). We describe a quantitative relationship between the intrinsic radiosensitivity and the residual breaks. The death of a human fibroblast is linked to 1.3 unrepaired chromosome break and 6.6 unrepaired DSB. Les cassures double-brin (CDB) de l'ADN constituent l'événement-clé susceptible d'expliquer l'effet létal des radiations ionisantes. Une revue générale de la littérature montre que, à l'exception d'un groupe minoritaire de tumeurs humaines, c'est surtout une déficience de réparation plutôt que l'incidence des dégâts qui est associée à la mort des cellules de mammifères irradiées. Toutefois, les arguments en faveur d'un lien entre radiosensibilité et CDB sont généralement indirects. À partir de 23lignées fibroblastiques humaines (5témoins et 18hypersensibles), nous décrivons une relation quantifiée entre la radiosensibilité intrinsèque et les cassures résiduelles de l'ADN et des chromosomes. La mort d'un fibroblaste humain irradié est associée à 6,6 CDB et 1,3 cassure chromosomique non réparées.

  10. Contribution à la clarification du régime juridique de la responsabilité de l’Etat résultant d’un placement en cellule de dégrisement

    OpenAIRE

    Edouard, Thierry

    2014-01-01

    Le 7 janvier 2011, les gendarmes du village de Camopi (Guyane française) étaient requis par une jeune femme se plaignant de violences conjugales. Le fauteur, M. A., finalement interpellé dans la soirée, est conduit à la brigade territoriale. Son état d’ébriété manifeste justifiait qu’il soit placé en cellule de dégrisement, dans l’attente d'une garde à vue. Au petit matin, l’époux violent est retrouvé sans vie, pendu au cordon de son calimbé. Au-delà du relatif retentissement médiatique, cett...

  11. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    Directory of Open Access Journals (Sweden)

    César Moreira Sampaio

    2001-06-01

    Full Text Available Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecções, na grande maioria, tiveram localização pré-septal (94,2%. As hemoculturas, realizadas em 21 pacientes, resultaram em 71% de negatividade, seguido por positividade para S. aureus (19%, H. influenzae (4,7% e flora mista (4,7%. Todos os pacientes foram tratados e curados com antibioticoterapia utilizando 16 quimioterápicos em 25 diferentes esquemas terapêuticos. A drenagem cirúrgica foi realizada em apenas 7 pacientes. Conclusão: A despeito da falta de uniformidade e diversidade de esquemas terapêuticos empregados nos casos estudados e da falta de avaliação oftalmológica na maioria dos casos, os pacientes foram curados sem complicações. Tal fato indica a necessidade de estudos prospectivos que visem a elaboração de protocolo terapêutico para as celulites da região orbitária na infância, que leve em consideração a relação custo-benefício positiva.Purpose: Retrospective study of clinical and therapeutic aspects in children with orbital and preseptal cellulitis. Methods: Fifty-two records of patients admitted at the São Rafael Hospital between 1990 and 1998 were reviewed. The age of the patients ranged from one month to twelve years. Based on a protocol elaborated by the authors the following aspects were analyzed: age, sex, predisposing factors, localization of the cellulitis in the orbital region, clinical, laboratorial and image findings as well as the clinical or surgical therapy and the occurrence of complications

  12. Systèmes effecteurs de l'immunité innée : reconnaissance et voies de signalisation.
    - Etude structurale des propriétés de reconnaissance des ficolines et du C1q
    - Etude cellulaire du rôle de la protéine ELMO1 dans l'élimination des cellules apoptotiques

    OpenAIRE

    Garlatti, Virginie

    2008-01-01

    Le système immunitaire inné génère des réponses inflammatoires contre les pathogènes ou les cellules dangereuses mais est aussi impliqué dans l'élimination tolérogène des cellules apoptotiques. La reconnaissance des cibles est médiée par un grand nombre de protéines membranaires et solubles. Parmi celles-ci, on trouve les protéines de reconnaissance du complément : C1q, MBL (« mannose-binding lectin) et ficolines. Bien que les propriétés structurales de reconnaissances de la MBL aient été ext...

  13. Etude de la synthèse du resvératrol et de ses dérivés (viniférines) par des suspensions de cellules de vigne et optimisation de la production en bioréacteur

    OpenAIRE

    Chastang, Thomas

    2014-01-01

    Le travail effectué au cours de cette thèse a permis une avancée importante dans la connaissance de l’élicitation des cellules de vigne. Nous avons étudié les effets de deux éliciteurs, le méthyljasmonate et la méthyl-β-cyclodextrine, employés seuls et en élicitation croisée sur des suspensions de cellules de vigne (porte-greffe 41B et Vitis labrusca), pour la production de stilbènes (resvératrol et viniférines). Ceci a permis d’atteindre des concentrations de resvératrol très élevées pour un...

  14. Acute hypocomplementemic post-infectious glomerulonephritis as a complication of sinus-related orbital cellulitis: case report Glomerulonefrite pós-infecciosa hipocomplementêmica aguda como complicação de celulite orbitária relacionada aos seios paranasais: relato de caso

    OpenAIRE

    Jayter Silva Paula; Antonio Augusto Velasco e Cruz; Patrícia Mitiko Santelo Akaishi; Tiana Burman

    2008-01-01

    Group A beta-hemolytic streptococcus is the most common agent implicated in post-infectious acute glomerulonephritis. We report a case of acute poststreptococcal glomerulonephritis associated with sinus-related orbital abscess in an 11-year-old boy treated with surgical drainage and intravenous ceftriaxone and clindamycin. Twelve days after supportive measures, renal function was normalized. We also discuss this potentially severe nonsuppurative complication of orbital cellulitis caused by gr...

  15. Prevalência de parasitos intestinais na comunidade indígena Maxakali, Minas Gerais, Brasil, 2009 Prevalencia de parásitos intestinales en la comunidad indígena Maxakali, Minas Gerais, Brasil, 2009 Prevalence of intestinal parasites in the Maxakali indigenous community in Minas Gerais, Brazil, 2009

    Directory of Open Access Journals (Sweden)

    João Luiz Pena

    2013-04-01

    Full Text Available O objetivo deste estudo foi determinar a prevalência de parasitos intestinais na etnia Maxakali em Minas Gerais, Brasil. Os exames parasitológico das fezes foram realizados através da técnica TF-Test, sendo as amostras fecais coletadas em três dias alternados, em tubos independentes, contendo formol a 10%, unificados para dupla filtragem por centrifugação. Triplicatas de uma alíquota do sedimento foram examinadas em microscópio (10x e 40x para identificação de ovos, cistos e larvas. A prevalência de parasitos (89,5% e do poliparasitismo (46% foi semelhante quanto ao sexo e idade, e variou entre as aldeias. As espécies prevalentes foram: Entamoeba histolytica/Entamoeba dispar (48,9%, Giardia duodenalis (32%, Entamoeba coli (40,8%, Endolimax nana (10,3%, ancilostomídeos (37,9%, Schistosoma mansoni (23,7%, Hymenolepis nana (18,6%, Strongyloides stercoralis (5,4%, Ascaris lumbricoides (4,9% e Trichuris trichiura (0,5%. Os Maxakali vivem em condições de vulnerabilidade social, e medidas de infraestrutura e de educação em saúde necessitam ser implementadas pelas instituições governamentais.El objetivo de este estudio fue determinar la prevalencia de parásitos intestinales en la etnia Maxakali. Los exámenes parasitológicos de las heces se realizaron a través de la técnica TF-Test, las muestras fecales se recogieron en tres días alternados, en tubos independientes, conteniendo formol a un 10%, unificados para un doble filtrado por centrifugación. Triplicados de una alícuota del sedimento se examinaron en microscopio (10x y 40x para la identificación de huevos, quistes y larvas. La prevalencia de parásitos (89,5% y del poliparasitismo (46% fue semejante en cuanto al sexo y edad, y varió entre las aldeas. Las especies prevalentes fueron: Entamoeba histolytica/Entamoeba dispar (48,9%, Giardia duodenalis (32%, Entamoeba coli (40,8%, Endolimax nana (10,3%, ancilostomídeos (37,9%, Schistosoma mansoni (23,7%, Hymenolepis nana

  16. Efectos de la desnutrición sobre la colagenización de anastomosis intestinales: análisis de procolágeno y telopéptido carboxiterminal mediante radioinmunoanálisis Role of malnutrition in intestinal anastomosis collagenization: an analysis of procollagen (PINP and carboxyterminal telopeptide (ICTP by radioimmunoassay

    Directory of Open Access Journals (Sweden)

    J. M. Álamo

    2007-02-01

    Full Text Available Introducción: diversos factores influyen en la cicatrización correcta de las suturas intestinales tras la práctica de una resección intestinal. Uno de los factores más implicados es el estado nutricional del paciente. Objetivos: evaluar la influencia de la desnutrición inducida sobre la viabilidad de una anastomosis intestinal primaria mediante el análisis del procolágeno (PINP como marcador de la síntesis de colágeno I, y del telopéptido carboxiterminal del colágeno I (ICTP como marcador de la destrucción del mismo. Métodos: 40 ratas Wistar y material de radioinmunoensayo. Métodos: diseñamos 2 grupos de ratas, 20 animales por cada grupo: grupo control (A y grupo "desnutrición" (B. Se analiza PINP e ICTP mediante RIA sobre tejido colónico homogeneizado, preanastomótico y anastomótico. Resultados: existen unos niveles menores de PINP en el colon de las ratas del grupo B comparado con el colon del grupo A (0,3620 y 0,4340 µg/g respectivamente (p = 0,032. Hay un mayor nivel de ICTP analizado en el colon del grupo B (0,9545 en contraposición a 0,8460 µg/g en el grupo A (p = 0,875. En las anastomosis del grupo B existe una menor síntesis de PINP en comparación con el grupo A (0,376 y 0,468 µg/g respectivamente, p = 0,002. Conclusiones: la anastomosis colónica incrementa los niveles de PINP e ICTP en el tejido cicatricial (p = 0,000; la malnutrición reduce la colagenización de las anastomosis (p = 0,000.Introduction: some clinical, anatomo-pathological, and technical factors influence the correct healing of intestinal suture following an intestinal resection. One of the most influential factors is patient nutritional status. Objectives: to evaluate the influence of malnutrition on the viability of primary intestinal anastomosis by the analysis of collagen I deposition. Methods: 40 Wistar rats, radioimmunoassay material. We used 2 groups of rats, 20 animals in each group: a control group (A and a "malnutrition" group (B

  17. Ultra-sonografia intra-oral e transcutânea cervical no diagnóstico diferencial de celulite e abscessos periamigdalianos Intraoral and transcutaneous cervical ultrasound in the differential diagnosis of peritonsillar cellulitis and abscesses

    Directory of Open Access Journals (Sweden)

    Bernardo Cunha Araujo Filho

    2006-06-01

    Full Text Available OBJETIVOS: O objetivo deste estudo é determinar a especificidade, sensibilidade e a acurácia da ultra-sonografia (USG intra-oral e transcutânea no diagnóstico de celulite e abscesso periamigdalianos. FORMA DE ESTUDO: Clínico Prospectivo. MATERIAL E MÉTODO: Trinta e nove pacientes foram atendidos no pronto-socorro de otorrinolaringologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo com diagnóstico clínico de celulite ou abscesso periamigdaliano. Em todos os pacientes, após a avaliação inicial, foram realizadas ultra-sonografias intra-oral e transcutânea. RESULTADOS: O USG intra-oral foi realizado em 35 casos e demonstrou sensibilidade de 95,2%, especificidade de 78,5% e a acurácia de 86,9%. A USG transcutânea foi factível em todos os 39 pacientes e diagnosticou abscesso periamigdaliano em 53,8% dos pacientes. A sensibilidade foi de 80%, a especificidade de 92,8% e a acurácia de 84,5%. CONCLUSÕES: O USG intra-oral foi bastante sensível no diagnóstico de abscessos periamigdalianos. O USG transcutâneo obteve especificidade superior ao intra-oral. Porém, quando o USG transcutâneo foi realizado em pacientes com trismo, este diagnosticou todos os abscessos periamigdalianos, já que se tratava de coleções grandes, comuns em pacientes com trismo. Estes exames tiveram acurácia semelhantes.AIMS: The objective of the present study was to determine the specificity, sensitivity and accuracy of intraoral and transcutaneous ultrasound (US in the diagnosis of peritonsillar cellulitis and abscess. STUDY DESIGN: Clinical-Prospective. MATERIAL AND METHODS: Thirty nine patients were seen at the otorhinolaryngology emergency department of the University Hospital, of the School of Medicine, University of São Paulo, with a clinical diagnosis of peritonsillar cellulitis or abscess. After initial evaluation, all patients were submitted to intraoral and transcutaneous US. RESULTS: Intraoral US was performed on

  18. De la microflore intestinale aux maladies hépatiques

    OpenAIRE

    Cunningham, Sophie

    2011-01-01

    Les hépatopathies alcoolique et non-alcoolique sont responsables d'une importante morbidité et mortalité. L'absence d'un traitement efficace prouvé pour ces maladies découle d'une compréhension imparfaite de leur pathogenèse. Les mécanismes physiopathologiques menant à ces hépatopathies sont l'objet d'intenses recherches expérimentales et cliniques. Dans ce contexte, un concept ayant évolué depuis plus d'un siècle a abouti, récemment, à une approche révolutionnaire du problème. Ce travail exa...

  19. Einfluss von Selenoprotein P auf die intestinale Tumorigenese im Mausmodell

    OpenAIRE

    Michaelis, Marten

    2009-01-01

    Das essentielle Spurenelement Selen (Se) wird als einziges Spurenelement über den genetischen Code als Bestandteil der 21. proteinogene Aminosäure Selenocystein (SeCys) in eine kleine Gruppe von Proteinen eingebaut. Als Bestandteil des aktiven Zentrums dieser Selenoproteine ist Se bzw. SeCys essentiell für deren Funktion. Die Biosynthese der Selenoproteine ist durch eine Reihe von Besonderheiten gekennzeichnet, so z.B. durch eine hierarchisch abgestimmte Versorgung der unterschiedlichen Organ...

  20. A clinical study on the therapeutic effect of rituximab in combination with autologous peripheral blood stem cell transplantation in treatment of CD20+ B cellulous non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Yong-sheng CHEN

    2013-07-01

    Full Text Available Objective To investigate the therapeutic effect of autologous peripheral blood stem cell transplantation (APBSCT in combination with rituximab in treatment of CD20+ B cellulous non-Hodgkin's lymphoma (B-NHL. Methods Sixty patients with CD20+ aggressive or refractory and recurrent B-NHL and treated with APBSCT in our department from Jan. 2005 to Jan. 2011 were admitted. All the subjects were divided into 2 groups according to their own choice: 25 patients received rituximab treatment (treatment group and 35 patients were treated without rituximab treatment (control group. All patients underwent chemotherapy and APBSCT. For patients in treatment group, rituximab was used with CHOP before collecting the stem cells and after the transplantation. After transplantation, rituximab and IL-2 were used in treatment group every 3-6 months as maintenance treatment. Results No side effect was observed during the use of rituximab either before or after transplantation. The mononuclear cell count in treatment and control group was (8.2±2.9×108/kg and (8.4±3.9×108/kg (P=0.822, respectively; CD34+cell count was (12.3±12.7×106/kg and (13.2±13.9×106/kg (P=0.799, respectively. Haemopoiesis reconstruction was successfully achieved in the patients of treatment group, while 3 patients in control group failed to have haemopoiesis reconstruction. No significant difference was found between two groups on the recovery time of neutrophilic granulocytes and platelets. All patients achieved complete remission. The average follow-up time was 22 months. The disease relapsed in two patients in treatment group and six in control group. The 3-year overall survival rate in treatment group (91.6% was a little higher than that in control group (69.5%, P=0.060. Conclusion To patients of CD20+ B lymphoma, the use of rituximab shows no side effect before or after collection of stem cell and hemopoiesis reconstruction, and the overall survival rate may be improved.

  1. Fragmentation radioinduite de l'ADN et réparation étudiée par immunomarquage anti poly(ADP-ribose)polymérase (PARP) dans les cellules de hamster chinois (CHO)

    Science.gov (United States)

    Bidon, N.; Varlet, P.; Noël, G.; Demurcia, G.; Salamero, J.; Averbeck, D.

    1998-04-01

    The poly(ADP-ribose)polymerase is a nuclear ubiquitous enzyme capable of binding to DNA breaks. Chinese hamster ovary cells were (CHO-K1) cultured on slides and γ-irradiated (137Cs) at a high (12.8 Gy/min) or medium dose rate (5 Gy/min), and immunolabelling against (ADP-ribose) polymers immediatly or three hours after irradiation. Quantification and localisation of γ-ray induced breaks was performed by confocal microscopy. The results show a dose effect relationship, a dose-rate effect and the signal disappearence after 3 hours at 37 °C. The presence of PARP activity appears to reflect γ-rays induced DNA fragmentation. Le poly(ADP-ribose)polymérase est une enzyme nucléaire ubiquitaire capable de se fixer sur les cassures de l'ADN. Sur une lignée sauvage de cellules d'ovaire de hamster chinois (CHO-K1) cultivée sur lame et irradiée aux rayons γ à haut débit de dose (HD) 12,8 Gy/min ou à moyen débit de dose (MD) 5 Gy/min, nous avons réalisé un immunomarquage anti-polymères d'ADP-ribose immédiatement après l'irradiation γ ou après trois heures d'incubation à 37 °C. La quantification et la localisation des lésions radioinduites ont été réalisées par microscopie confocale. Les résultats montrent une relation dose-effet et un effet de débit de dose, ainsi qu'une disparition du signal après 3 heures à 37 °C. La présence de la PARP semble donc bien refléter la fragmentation radioinduite de l'ADN.

  2. Oral glutamine in addition to parenteral nutrition improves mortality and the healing of high-output intestinal fistulas Glutamina oral en adición a nutrición parenteral mejora la mortalidad y la cicatrización de fístulas intestinales de alto débito

    Directory of Open Access Journals (Sweden)

    J. E. de Aguilar-Nascimento

    2007-12-01

    Full Text Available Objective: Anastomotic leakage is one of the most important causes of morbidity and mortality in gastrointestinal surgery. We investigated the effect of oral glutamine on the healing of high-output intestinal fistula. Setting: A tertiary Universitary Hospital of the University of Mato Grosso, Cuiaba, Brazil. Patients and methods: 28 patients (25 males and 3 females; median age = 45 [18-71] years old admitted with high output post-operative small bowel fistulas (median volume in 24 h: 850 [600-2,200] mL during a 4 years period were retrospectively studied. Interventions: In the first two years 19 (67.9% patients received only TPN as the initial nutritional support. In the last two years however, due to a change in the protocol for the nutritional support in cases of intestinal fistula 9 patients (32.1% received oral glutamine (0.3 g/kg/day; 150 mL/day in addition to TPN. Endpoints of the study were mortality, resolution of the fistula, and length of hospital stay (LOS. Results: The overall mortality was 46.4% (13 patients. Fistula closure was observed in all other 15 patients (53.6% that survived. In the subset of survived patients LOS was similar in those who received or not received glutamine. The multivariate regression analysis showed that resolution of the fistula was 13 times greater in patients that received oral glutamine (OR = 13.2 (95% CI = 1.1-160.5; p = 0.04 and 15 times greater in non-malnourished patients (OR = 15.4 [95% CI = 1.1- 215.5]; p = 0.04. Conclusions: We conclude that oral glutamine accelerated the healing and diminished the mortality in this series of patients with post-operative high-output intestinal fistula receiving TPN.Objetivo: La fístula anastomótica es una de las principales causas de morbilidad y mortalidad en cirugía general. Investigamos el efecto de la glutamina oral en la cicatrización de fístulas intestinales de alto débito. Ámbito: Una unidad terciaria de un Hospital Universitario de la Universidad

  3. Fatores associados à ocorrência de parasitoses intestinais em uma população de crianças e adolescentes Factores asociados a la ocurrencia de parasitosis intestinales en una población de niños y adolescentes Factors associated with intestinal parasitosis in a population of children and adolescents

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    Vinícius Silva Belo

    2012-06-01

    Full Text Available OBJETIVOS: Analisar a prevalência de infecções por parasitos intestinais em crianças e adolescentes matriculados em escolas de ensino fundamental no município de São João del-Rei, Minas Gerais, e os fatores associados à infecção. MÉTODOS: Estudo epidemiológico seccional, realizado entre março/2008 e julho/2009. Foram realizados exames coproscópicos por sedimentação espontânea e Kato-Katz em 1.172 escolares. Foram ajustados modelos de regressão logística múltipla para o estudo dos fatores associados às infecções em geral e, separadamente, por helmintos e por protozoários. RESULTADOS: A prevalência de infecções foi de 29%, havendo uma variação de 7 a 83%, respectivamente, entre as escolas de menor e maior ocorrência. A presença de instalação sanitária no domicílio foi associada a uma ocorrência menor de helmintos; o aumento na idade dos escolares associou-se a uma maior ocorrência de protozoários e de parasitos em geral; enquanto a presença de filtro de água e a localização do domicílio em área urbana mostraram-se associadas a uma ocorrência menor dos três desfechos analisados. Em todas as regiões, foi registrado o consumo de medicação preventiva contra helmintos. CONCLUSÕES: Desigualdades nas condições de vida tornaram as prevalências diferenciadas entre as regiões do estudo. O estudo ressalta a necessidade de promover o uso de filtros de água nas residências de áreas endêmicas e de avaliar o consumo preventivo de medicamentos anti-helmínticos na dinâmica e na saúde dos indivíduos. Medidas de controle que levem em conta os fatores descritos devem ser prioritárias em nível de Saúde Pública.OBJETIVOS: Analizar la prevalencia de infecciones por parasitas intestinales en niños y adolescentes matriculados en escuelas de enseñanza primaria en el municipio de São João del-Rei, Minas Gerais (Brasil, y los factores asociados a la infección. MÉTODOS: Estudio epidemiológico seccional

  4. Infantile maxillary sinus osteomyelitis mimicking orbital cellulitis

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    Nagarajan Krishnan

    2014-01-01

    Full Text Available Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococcus aureus growth and the child improved with intravenous cloxacillin therapy. This case is presented due to the rarity of its presentation in this age group and for awareness to consider this entity in children having fever and peri-orbital swelling.

  5. Infantile Maxillary Sinus Osteomyelitis Mimicking Orbital Cellulitis

    OpenAIRE

    Nagarajan Krishnan; Nathan Ramamoorthy; Suresh Panchanathan; Balasundaram, Jothiramalingam S

    2014-01-01

    Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococc...

  6. Periorbital cellulitis due to cutaneous anthrax.

    Science.gov (United States)

    Gilliland, Grant; Starks, Victoria; Vrcek, Ivan; Gilliland, Connor

    2015-12-01

    Virgil's plague of the ancient world, Bacillus anthracis, is rare in developed nations. Unfortunately rural communities across the globe continue to be exposed to this potentially lethal bacterium. Herein we report a case of periorbital cutaneous anthrax infection in a 3-year-old girl from the rural area surrounding Harare, Zimbabwe with a brief review of the literature. PMID:25763844

  7. Parasitoses intestinais se associam a menores índices de peso e estatura em escolares de baixo estrato socioeconômico Parasitosis intestinales se asocian con menores índices de peso y estatura en niños de bajo nivel económico Intestinal parasitoses are associated with lower values of weight and height in school-aged children from low socioeconomic level

    Directory of Open Access Journals (Sweden)

    Humberto B. Araujo Filho

    2011-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência de parasitoses intestinais, correlacionando-as com os fatores socioeconômicos e ambientais, peso, estatura e hemoglobina, em crianças de dois estratos socioeconômicos, no município de Osasco (SP. MÉTODOS: Estudo transversal, comparando 84 crianças de seis a dez anos, residentes em área sem saneamento básico e moradia precária, com 35 crianças de escola particular no mesmo município, que possuíam boas condições socioeconômicas e de moradia. Excluíram-se aquelas com diarreia há menos de 30 dias ou doença grave. Utilizou-se questionário padronizado para avaliar as condições socioambientais. A avaliação nutricional foi realizada mediante escores Z de peso para idade, estatura para idade e índice de massa corpórea. A determinação da hemoglobina em amostra de sangue capilar foi realizada pelo método Hemocue® e a pesquisa de parasitas intestinais, pelos métodos de Hoffman, Ritchie, Kinyoun e swab anal. RESULTADOS: Parasitose intestinal ocorreu em 60,7% das crianças da favela e em 5,9% das crianças da escola particular (pOBJETIVO: Evaluar la prevalencia de parasitosis intestinales correlacionándolas con los factores socioeconómicos y ambientales, peso, estatura y hemoglobina, en niños de dos niveles socioeconómicos en el municipio de Osasco, São Paulo (Brasil. MÉTODOS: Se realizó un estudio transversal, comparando 84 niños entre 6 y 10 años, residentes en área sin saneamiento ambiental y vivienda precaria, con 35 niños de escuela privada en el mismo municipio, que poseían buenas condiciones socioeconómicas y de vivienda. Se excluyeron aquellas con diarrea hace menos de 30 días o enfermedad grave. Se utilizó cuestionario estandarizado para evaluar las condiciones socioambientales. La evaluación nutricional fue realizada mediante escores Z de peso para la edad, estatura para la edad e índice de masa corporal. La determinación de la hemoglobina en muestra de sangre capilar

  8. Die kurzkettige Fettsäure Butyrat stabilisiert die epitheliale Barrierefunktion des Darmes durch HNF-4α-abhängige Herabregulierung der Claudin-2-Expression

    OpenAIRE

    Plöger, Svenja

    2011-01-01

    Butyrate is known to have beneficial effects on colonocytes including preservation of epithelial barrier function or anti-inflammatory influences and has also an important role in cell differentiation, apoptosis induction and gene regulation by acting as a histone deacetylase (HDAC) inhibitor. Aim of this study was to characterize the mechnisms induced by butyrate to improve the epithelial barrier function of the intestine. By means of the human colon cancer cell line HT-29/B6-GR/MR as a m...

  9. Citotossicity in immune system's cells exposed in vitro to a microwave electromagnetic field in two different exposure systems operating at mobile telephones frequencies; Citotossicita' in cellule del sistema immunitario esposte in vitro al campo elettromagnetico a microonde in due diversi sistemi espositivi operanti alle frequenze della telefonia mobile

    Energy Technology Data Exchange (ETDEWEB)

    Scarcella, E.; Ardoino, L.; Galloni, P.; Mancini, S.; Marino, C. [ENEA, Divisione Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche Casaccia, Rome (Italy)

    2001-07-01

    funzionamento di cellule macrofagiche stabilizzate e coltivate in vitro (RAW 264.7) responsabili dei meccanismi di difesa specifica e aspecifica del sistema immunitario. Sono stati, inoltre, standardizzati due diversi sistemi espositivi operanti a 900 MHz a differenti livelli di densita' di potenza (da 1 a 100 W/m{sup 2}) per garantire condizioni elettromagnetiche omogenee, idonee condizioni di incubazione delle cellule e la riproducibilita' degli esperimenti. Il lavoro di standardizzazione dei sistemi espositivi e i risultati sperimentali di questa ricerca, che hanno evidenziato differenze significative della crescita e della funzionalita' macrofagica solo al livello di densita' di potenza piu' elevato (100 W/m{sup 2}), ma recuperare dopo 48 ore dall'esposizione, risultano essere preliminari e propedeutici per una programmazione sperimentale futura atta ad approfondire una valutazione bio-tossicologica in vitro.

  10. Acute hypocomplementemic post-infectious glomerulonephritis as a complication of sinus-related orbital cellulitis: case report Glomerulonefrite pós-infecciosa hipocomplementêmica aguda como complicação de celulite orbitária relacionada aos seios paranasais: relato de caso

    Directory of Open Access Journals (Sweden)

    Jayter Silva Paula

    2008-08-01

    Full Text Available Group A beta-hemolytic streptococcus is the most common agent implicated in post-infectious acute glomerulonephritis. We report a case of acute poststreptococcal glomerulonephritis associated with sinus-related orbital abscess in an 11-year-old boy treated with surgical drainage and intravenous ceftriaxone and clindamycin. Twelve days after supportive measures, renal function was normalized. We also discuss this potentially severe nonsuppurative complication of orbital cellulitis caused by group A beta-hemolytic streptococcus.Os estreptococos beta-hemolíticos do grupo A são os agentes mais comumente envolvidos na glomerulonefrite aguda pós-infecciosa. Relatamos um caso de glomerulonefrite pós-estreptocócica aguda associada a um abscesso orbitário secundário à sinusite, em menino de 11 anos de idade, o qual foi tratado com ceftriaxona e clindamicina endovenosas e drenagem cirúrgica. Doze dias após tratamento de suporte, a função renal se normalizou. Também discutimos a importância desta grave e potencial complicação não supurativa das celulites orbitárias causadas pelos estreptococos beta-hemolíticos do grupo A.

  11. CELULITIS FACIAL ODONTOGÉNICA SEVERA INFRECUENTE CAUSADA POR CITROBACTER FREUNDII PRODUCTORA DE AMPC EN UN PACIENTE CON DIABETES MELLITUS 2. REPORTE DE CASO CELULITE FACIAL ODONTOGÊNICA SEVERA INFREQUENTE CAUSADA POR CITROBACTER FREUNDII PRODUTORA DE AMPC EM UM PACIENTE COM DIABETES MELLITUS 2. RELATÓRIO DE CASO UNCOMMON SEVERE ODONTOGENIC FACIAL CELLULITIS CAUSED BY AMPCPRODUCING CITROBACTER FREUNDII IN A PATIENT WITH TYPE 2 DIABETES MELLITUS. CASE REPORT

    Directory of Open Access Journals (Sweden)

    CAMILO ESLAVA

    2012-06-01

    freundii é inusual nas infecções odontogênicas, sua capacidade para produzir betalactamases de amplo espectro (AmpC lhe permite bloquear a ação dos antibióticos de uso empírico em Cirurgia Oral e Maxilofacial. A seguir apresentamos o caso de uma paciente de 61 anos com Diabetes Mellitus tipo 2 e celulite facial odontogênica por Citrobacter freundii produtora de AmpC.The management of odontogenic facial cellulitis is still a controversial issue in the field of Oral and Maxillofacial Surgery. Surgical and therapeutic principles have undergone modifications based on clinical findings, imaging and microbiological over time. In patients with type 2 Diabetes Mellitus the risk of opportunistic bacterial infections is increased thus suffering longer hospitalization periods than the nondiabetic population. The literature is clear by setting the clinical and microbiological differences of odontogenic facial cellulitis in this group of patients, but there is no surgical medical protocol for them. Klebsiella pneumoniae is the most common microorganism isolated while Citrobacter freundii is unusual in relation to oral infections; their ability to produce ESBLs (AmpC allows them to block the action of empirical antibiotics used in Maxillofacial Surgery. We present the case of a 61 year old patient with type 2 Diabetes Mellitus and odontogenic facial cellulitis caused by AmpCproducing Citrobacter freundii.

  12. Impatto di rifaximina sul microbiota intestinale: selezione di bifidobatteri antibiotico resistenti

    OpenAIRE

    Turroni, Silvia

    2008-01-01

    The ideal approach for the long term treatment of intestinal disorders, such as inflammatory bowel disease (IBD), is represented by a safe and well tolerated therapy able to reduce mucosal inflammation and maintain homeostasis of the intestinal microbiota. A combined therapy with antimicrobial agents, to reduce antigenic load, and immunomodulators, to ameliorate the dysregulated responses, followed by probiotic supplementation has been proposed. Because of the complementary mechanisms of a...

  13. Intestinal parasitic infections, cysticercosis and hydatic diseases Parasitosis intestinales, cisticercosis e hidatidosis

    OpenAIRE

    David Botero

    1990-01-01

    This paper offers an up to date review of the intestinal parasitic infections, cysticercosis and hydatic disease found In Colombia. Their main epidemiological, clinical, preventive and therapeutic features are presented, to provide the reader with a current view of their public health Importance, prevalence and impact on morbidity and mortality.

    Lichtphysiologische Untersuchungen an Cercarien von Schistosoma mansoni, eines Erregers menschlicher intestinaler Bilharziose

    OpenAIRE

    Kopf, Stefan

    2007-01-01

    In unserer Arbeit führten wir lichtreizphysiologische Untersuchungen an Cercarien von Schistosoma mansoni durch, der Erreger der intestinalen Bilharziose. Wir konnten nachweisen, daß Cercarien ihre höchste Aktivität bei 500 nm Lichtwellenlänge und 10000 Cd Lichtstärke haben. Ferner stellten wir fest, daß Dunkelreize die Passivphasen und die anschließende Aktivphase verkürzen, während Lichtreize die Passivphasen und die folgende Aktivphase verlängern. Eine Dunkelreizgabe in der Aktivphase verk...

  14. Monografía sobre el intestino grueso : enfermedades inflamatorias intestinales

    OpenAIRE

    López Mora, Gema

    2014-01-01

    El intestino grueso es un órgano con forma de tubo, de aproximadamente un metro y medio de largo, que forma parte del sistema digestivo. Consta de varias partes llamadas ciego (con su apéndice vermiforme); colon, en donde ponemos diferenciar colon ascendente, transverso, descendente y sigmoide; recto y ano. Sus paredes están cubiertas por un epitelio simple cilíndrico, que no presenta pliegues ni vellosidades y, que forma numerosas glándulas mucosas tubulares llamadas criptas de Lierberkühn, ...

  15. Modulation oxidativer Zellschäden durch phenolische Apfelsaftinhaltsstoffe und deren intestinale Abbauprodukte in humanen Kolonzellen

    OpenAIRE

    Bellion, Phillip

    2009-01-01

    Es ist bekannt, dass die Genese von Darmerkrankungen von der aufgenommenen Nahrung beeinflusst wird. Der Genuss von Apfelprodukten mit hoher antioxidativer Wirksamkeit könnte daher zur Prävention ROS-assoziierter Erkrankungen beitragen. Ziel der vorliegenden Arbeit war die Untersuchung von polyphenolreichen Extrakte aus Apfelsaft (AE01–AE07), Tresterextraktionssaft (AE03B, AE06B) und Apfelschalen (GS, PE) sowie von Polyphenolen auf ihr Potenzial zur Verringerung oxidativer Zellschäden in Caco...

  16. Etnobotánica medicinal y parasitosis intestinales en la isla de Ometepe, Nicaragua

    OpenAIRE

    López Sáez, José Antonio; Pérez Soto, Josué

    2010-01-01

    [EN]: Thirteen Nicaraguan medicinal plants used in the community of Tilgüe, Ometepe Island, were investigated for their activity against intestinal parasitoses. Ethnomedical values and metabolites implicated in their properties are discussed.

  17. Interacciones de las bifidobacterias con las células intestinales humanas

    OpenAIRE

    Sánchez García, Borja; Gueimonde Fernández, Miguel; Suárez, Ana; Ruas-Madiedo, Patricia; Margolles Barros, Abelardo

    2010-01-01

    Los avances científicos en torno a la importancia de la dieta en la salud han dado origen a un creciente interés en los alimentos funcionales y, especialmente, en los productos probióticos. Las bifidobacterias son uno de los grupos de microorganismos probióticos más destacados, ya que desde el nacimiento colonizan selectivamente el tracto intestinal humano. Dado que las alegaciones acerca de sus efectos beneficiosos no siempre se baan en evidencias científicas, su uso en productos funcionales...

  18. Intestinal small bowel lymphomas - diagnosis and treatment; Primaer intestinale Lymphome - Diagnosestellung mittels CT und Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Goessmann, H.; Reith, H.B. [Klinikum fuer Visceral-, Thorax und Gefaesschirurgie, Klinikum Konstanz (Germany); Goerlitz, T.; Beck, A. [Inst. fuer Roentgendiagnostik und Nuklearmedizin, Klinikum Konstanz (Germany)

    2006-07-01

    Primary intestinal lymphomas are most common in the stomach. The mucosa associated lymphatic tissue (MALT)-lymphoma which is closely associated with helicobacter pylori is very well known. In most cases, these malignancies are from B-cells origin. Another possible point of manifestation, although not well known, is the small bowel. Both tumors have enormous capabilities to enlarge in the abdominal cave. This is responding to their often asymptomatic manifestation. The symptoms, if they occur, are widespread and unspecific. Ileus, diarrhae, abdominal pain or bleeding will be observed, in rare cases also perforation or gastrointestinal or cutaneous fistulas. Diagnostic imaging often demonstrates a tumour of massive size by then, which is echopoor in the abdominal ultrasound. Our report concerns two cases of small intestine lymphomas, which were diagnosed by CT-scanning and treated in our clinic in only a short period of time. The first case was a low malignant jejunal lymphoma which was almost asymptomatic, whereas the second case had an ileus, due to compression of the intestine because of a high malignant lymphoma of the ileocecal region. (orig.)

  19. Skin and Soft Tissue Infection (Cellulitis) (Beyond the Basics)

    Science.gov (United States)

    ... Stock Options: Magnolia Medical Technologies [Medical diagnostics (Blood culture techniques)]. Other Financial ... Contributor disclosures are reviewed for conflicts of interest by the editorial group. When found, ...

  1. Orbital Cysticercosis - masquerading as preseptal cellulitis with ptosis.

    Science.gov (United States)

    Raj, Amit; Arya, Sudesh Kumar; Topiwala, Pratik; Gupta, Panchmi; Sood, Sunandan

    2015-07-01

    We are sharing a case of orbital cysticercosis,which presented to us initially with simple ptosis and later on with upper lid inflammation and restricted ocular motility in upgaze. Human cysticercosis, a parasitic infection caused by Cysticercus cellulosae, the larval form of the cestode, Taenia solium, is a benign infection of the subcutaneous tissues, inter-muscular fascia, muscles and other organs. Though it exists worldwide, it is more prevalent in the developing countries of Latin America, Asia and Africa, especially in areas where under-cooked pork is consumed regularly (Pushker et al, 2001). However, 5 year study of 33 cases of Ocular/Adnexal cysticercosis showed seventy percent of patients were of low socioeconomic group and 70% were strictly vegetarians (Atul et al, 1995). The clinical manifestation of orbital cysticercosis is entirely different from neuro-cysticercosis or cysticercosis of other parts of body. Diagnosis of cysticercosis is mainly based on highly specific radiological signs and history of exposure in endemic areas. PMID:27363971

  2. Orbital cellulitis and pyogenic meningitis rare sequelae after snake bite

    OpenAIRE

    Rupeshkumar Naik

    2016-01-01

    The incidence of snake bite is underestimated. Worldwide around 2800 species of snakes are known out of which 375 species are venomous. Snake bite effects on nervous, cardiac, renal systems. A 10-year-old male boy was got admitted after five days treating with a local snake bite professional. On admission, he was treated with antibiotics for an infection. His cerebellum and most of the brain noted with streaks of pus. Here a case of intracranial complication following snake bite is reported. ...

  3. Ciprofloxacin-Resistant Aeromonas hydrophila Cellulitis following Leech Therapy

    OpenAIRE

    Giltner, Carmen L.; Bobenchik, April M; Uslan, Daniel Z.; Deville, Jaime G.; Humphries, Romney M.

    2013-01-01

    We report a case of surgical site infection with ciprofloxacin-resistant Aeromonas hydrophila following leech therapy. Antimicrobial and genetic analyses of leech and patient isolates demonstrated that the resistant isolates originated from the leech gut microbiota. These data suggest that ciprofloxacin monotherapy as a prophylaxis regimen prior to leech therapy may not be effective in preventing infection.

  4. Remote cells destruction; Detruire les cellules a distances

    Energy Technology Data Exchange (ETDEWEB)

    Pezet, A

    2009-11-15

    Three methods for a non invasive surgery are described. High intensity focused ultrasonics to treat an uterine fibroma or prostate cancer presents the advantages to destroy ill cells by high temperature (80 to 100 celsius degrees and the millimetric precision allows to preserve the sane tissues. Echography is used to give images and the volume to treat then are sent the high intensity focused ultrasonics (H.I.F.U.) to destroy the tumor. A second method progresses, the laser method: a thin beam of light, coming from a laser diode and transmitted by an optical fiber of 200 microns diameter comes and heats and kills the cancerous cells. With NMR imaging the cancerous cells from 1 to 2 mm are detected but its is necessary to introduce the optical fiber in the ill tissue. The third method concerns protons therapy used in radiotherapy. The beam energy determines the depth where the protons stop and give their energy (with a 201 MeV energy range the tumors located at 32 centimeters under the skin can be destroyed.The volume to treat is determined with a scanner and a three dimensional calculation reconstruction of image. (N.C.)

  5. Not What It Seems: Deep Tissue Infection Presenting as Cellulitis

    Directory of Open Access Journals (Sweden)

    Caroline T. Brandon

    2015-10-01

    Full Text Available A 34-year-old male with diabetes presented to the emergency department with four days of progressively worsening redness, swelling and pain to his left buttock. The patient denied fevers, chills, rectal pain or purulent drainage from his rectum. His initial vital signs were heart rate of 82; blood pressure of 146/92; and temperature of 98.2°F. The left buttock had a poorly circumscribed area of induration; however, there was no fluctuance or crepitace. Rectal exam was unremarkable. Because the patient’s buttock pain was disproportionate to his exam findings, a point-of-care ultrasound was performed to determine if a more extensive process was present. The ultrasound demonstrated cobblestoning, fascial thickening with edema, and a large 4.5cm fluid collection extending and adjacent to the rectum.

  6. Orbital and periorbital cellulitis: an 11-year case series

    OpenAIRE

    Monteiro, G.; Dias, A.; Teixeira, E.; Pereira, J; Santos, E.

    2013-01-01

    RESUMO Introdução: As celulites da região orbitária são uma patologia relativamente comum, em idade pediátrica, com um potencial de gravidade estimável. Objetivos: A presente casuística tem como objetivo a revisão da epidemiologia, etiologia e abordagem terapêutica dos casos de celulite da região orbitária internados no Serviço de Pediatria do Centro Hospitalar Tondela-Viseu (CHTV), no período de 11 anos. Material e Métodos: Estudo retrospetivo dos processos clínico...

  7. Chirurgisches und klinisches Outcome von Patientinnen mit fortgeschrittenem Ovarialkarzinom nach Salvage Operationen wegen intestinaler Komplikationen und daraus resultierendem Kurzdarmsyndrom

    OpenAIRE

    Kwee, Sara-Lea

    2014-01-01

    Surgery for patients with highly advanced epithelial ovarian cancer in life- threatening emergencies (i.e. bowel obstruction, intestinal perforation or fistula) are a major challenge for physicians and constitutes a therapeutic predicament. The objective of this study was to evaluate surgical and clinical outcome of patients in this highly palliative situations. All patients with an epithelial ovarian cancer who were operated as an emergency with an extraperitoneal en-bloc intestinal rese...

  8. Les cellules Natural Killer (NK) dans l’allergie : effet de la chimiokine CCL18 sur les cellules NK humaines et rôle des cellules NK sur les éosinophiles

    OpenAIRE

    Awad, Ali,

    2014-01-01

    Allergic diseases are steadily increasing both in prevalence and severity. Known physiopathological mechanisms involve the induction of a Th2 response by dendritic cells, leading to IgE production and inflammation, in particular linked to the recruitment of eosinophils. Eosinophils are heavily involved in injury and tissue dysfunction and contribute to the maintenance of inflammation. Different cells of innate immunity were shown to be involved in the control of allergic reaction. Among them,...

  9. Entrée du virus de l'hépatite C et transmission de cellule à cellule : implications pour le cycle viral et le traitement antiviral

    OpenAIRE

    Xiao, Fei

    2014-01-01

    Hepatitis C virus (HCV) poses a threat to global health with infecting about 170 million people. Current therapies cannot cure all the patients infected with HCV and have obvious side effects. In the first part of my thesis, we uncovered combinations of direct-acting antivirals (DAAs) and entry inhibitors caracterized by a synergistic effect in prevention and treatment of HCV infection using HCV cell culture models and human liver chimeric uPA-SCID mice, thereby providing a new strategy to co...

  10. ETUDE ET SIMULATION DE CELLULES PHOTOVOLTAIQUES A CONTACTS ARRIERES INTERDIGITÉS SOUS ENVIRONNEMENT SILVACO

    OpenAIRE

    MOHAMMEDI, Mohammed

    2012-01-01

    Ces dernières années un engouement particulier a été donné au remplacement des énergies fossiles et fissiles, épuisables, dangereuses et polluantes, par les énergies renouvelables et en particulier le solaire, propres et inépuisables. Grace à l’effet photovoltaïque la conversion de l’énergie solaire en électricité est possible. Depuis les années cinquante plusieurs travaux et élaborations des dispositifs photovoltaïques ont été élaborés. Les premiers travaux étaient destinés su...

  11. Response of hematopoietic stem cells to ionizing radiation; Reponse des cellules souches hematopoitiques aux radiations ionisantes

    Energy Technology Data Exchange (ETDEWEB)

    Simonnet, A

    2008-12-15

    Hematopoietic stem cells (HSCs) maintain blood and immune system throughout life and restore them after hematological injuries. Exposure of an organism to ionizing radiation (IR) causes rapid and acute myelosuppression and challenges the replenishment capacity of HSCs. Yet, the precise damages that are generated remain largely unexplored. To better understand these effects, phenotypic and functional changes in the stem/progenitor compartments of sublethally irradiated mice were monitored over a ten week period after radiation exposure. We report that shortly after sublethal IR-exposure, HSCs, defined by their repopulating ability, still segregate in the Hoechst dye excluding side population (SP); yet, their Sca-1 (S) and c-Kit (K) expression levels are increased and severely reduced, respectively, with a concurrent increase in the proportion of SP{sup SK} cells positive for established indicators of HSC presence: CD150{sup +} and CD105{sup +}. A great proportion of HSCs quickly but transiently enter the cell cycle to replenish the bone marrow of myelo-ablated mice. Ten weeks after, whereas bone marrow cellularity has recovered and hematopoietic homeostasis is restored, major phenotypic modifications can be observed within the Lin{sup -/low} Sca-1{sup +} c-Kit{sup +} (LSK) stem/progenitor compartment: CD150{sup +}/Flk2{sup -} and CD150{sup -}/Flk2{sup +} LSK cell frequencies are increased and dramatically reduced, respectively. CD150{sup +} LSK cells also show impaired reconstitution capacity, accrued number of {gamma}-H2AX foci and increased tendency to apoptosis. This demonstrates that the LSK compartment is not properly restored 10 weeks after sublethal exposure, and that long-term IR-induced injury to the bone marrow proceeds, at least partially, through direct damage to the stem cell pool. Thrombopoietin (TPO) has been shown to promote the survival of lethally irradiated mice when administrated quickly after exposure. We investigated the mechanisms underlying this effect, and found in a competitive transplant experiment that a single TPO administration rescued the IR-impaired reconstitution capacity of HSCs early after exposure. In addition, the use of marrow cells from transgenic ubiquitous luciferase-expressing donors combined with bioluminescence imaging technology provided a valuable strategy that allowed visualizing HSC homing of TPO-treated compared to untreated irradiated donors, and enabled the identification of a preferential cellular expansion sites which were inaccessible to investigation in most studies. Finally, we observed that TPO injection right after irradiation considerably attenuates IR-induced long-term injury to the stem/progenitor compartment. Altogether, these data provide novel insights in the cellular response of HSC to IR and the beneficial effects of TPO administration to these cells. (author)

  12. Bacteriemia en pacientes internados con celulitis Bacteremia in patients hospitalized with cellulitis

    OpenAIRE

    Juan S. Lasa; María L. Fernández Recalde; Bárbara C. Finn; Julio E. Bruetman; José Peroni; Pablo Young

    2012-01-01

    La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB). Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celuliti...

  13. Influence de revetements bioactifs sur les cellules endotheliales: Vers des protheses vasculaires non thrombotiques

    Science.gov (United States)

    Fadlallah, Hicham

    Developing vascular prostheses of small diameter to replace vessels closed by atherosclerosis remains a challenge because of the risk of thrombosis. Seeding of endothelial cells, which have antithrombogenic properties, is a promising solution, but we must create surfaces which promote their adhesion and retention to resist shear stresses created by the blood flow on the surface. This master's project aimed at investigating the effect of a plasma polymerized coating rich in primary amines (called LP), with or without elements of the extracellular matrix (Fibronectin (FN) or chondroitin sulphate (CS)) on the endothelial cells and hemocompatibility of polyethylene terephthalate (PET). The adhesion, growth and retention of human umbilical vein endothelial cells (HUVECs) on PET and LP, in the presence and absence of FN or CS, have been studied. In addition, platelet adhesion on different surfaces was evaluated by a perfusion test with whole blood, platelets being previously labeled with rhodamine. Finally a double fluorescent labeling (using Cellview Maroon to mark the HUVECs and CD61 antibody for platelets) was developed to study the retention of endothelial cells, under blood flow and verify their non thrombogenic character. The results obtained show that both the LP coating and the adsorbed FN, strongly increase both the cellular adhesion and growth on PET; however they have no additional effect when the two are combined. They also augment cellular retention to surface, but this remains incomplete. Moreover we observed that the plasma coating (LP) greatly increases the thrombogenicity of the surface, with strong platelet adhesion and activation. This thrombogenicity is extremely reduced when endothelial cells cover the surface, but cell loss under the effect of shear produced by the perfusion creates significant areas of platelet adhesion. The grafting of CS on LP also permits good HUVECs adhesion, growth and retention under shear stress on HUVEC, with no difference from the LP alone. In addition, the CS sharply decreases the platelet adhesion, which is found below the value observed for PET. The double cell labeling also showed that cells adhered on LP+CS has an anti-thrombotic phenotype and can resist blood flow. These studies suggest that a coating of CS is a promising strategy for vascular prosthesis given the combination of the good adhesion of endothelial cells and the low thrombogenicity of the underlying surface. Keywords: vascular prostheses, polymers, bioactive coating, thrombogenicity, HUVECs.

  14. Rôle des cellules Natural Killer dans l'asthme allergique

    OpenAIRE

    Plé, Coline

    2010-01-01

    The prevalence and severity of allergic diseases are increasing in western countries. Known pathophysiological mechanisms involve the induction of Th2 response by dendritic cells, leading to IgE production and inflammation. The innate immunity was recently highlighted in the control of adaptive immunity, which is antigen specific. However, the role of Natural Killer (NK) cells, innate cells mainly known for their anti-tumoral and anti-microbial functions, is still unknown in allergic patholog...

  15. Orbital wall infarction mimicking periorbital cellulitis in a patient with sickle cell disease

    International Nuclear Information System (INIS)

    Orbital wall infarction and subperiosteal haematomas are unusual manifestations of sickling disorders. Here we report an 11-year-old girl with sickle cell anaemia having multiple skull infarctions including the orbital bony structures associated with subperiosteal haematomas. The diagnosis was made by MRI, which showed bone marrow changes and associated haemorrhagic collections. The patient was successfully managed without surgical intervention. (orig.)

  16. Bullous eosinophilic cellulitis (Wells' syndrome) associated with Churg-Strauss syndrome

    NARCIS (Netherlands)

    Schuttelaar, M L A; Jonkman, M F

    2003-01-01

    We report a patient with Churg-Strauss syndrome (CSS) with asthma, eosinophilia, nasal polyposis and ANCA-associated multisystem vasculitis, who's skin eruption started with erythematous urticarial-plaques followed by haemorrhagic bullae. Histology of the plaques revealed 'flame figures' in the derm

  17. Polymer photovoltaic cells; Etude et realisation de cellules photovoltaiques en polymere

    Energy Technology Data Exchange (ETDEWEB)

    Sicot, L.

    1999-09-29

    We study organic photovoltaic cells based on a semiconducting polymer. The first photovoltaic cells we realize are Schottky cells. Their structure are ITO/Polymeric film/Au. Metallic electrode is made of aluminium or gold. The organic layer is made of pure poly(3-butyl-thiophene) or of a blend of the polymer and a dye, the 1,3-bis(di-cyano-methylidene)-2-(4-dibutyl-amino-benzylidene)indane. We study the influence of the nature of the electrode on the conversion efficiency. We also study the variations of the photovoltaic parameters as functions of the thickness of the polymeric film and of the doping ratio of the dye. The performances of this kind of cells depends on the interface between the organic layer and the ITO. Its morphology, particularly its rugosity, and its electrical properties are not easy to control. By depositing a layer of a derivative of perylene on the ITO, we move the photo-generation zone to the interface between the two organic films. The efficiency of this p-n cell is higher than the one measured with the Schottky cell. Nevertheless, we have observed a decrease of the performances of our cells due to the degradation of the dye and the polymer when they are illuminated at high intensity of light during a long time. (author)

  18. Adult-onset Invasive Haemophilus influenzae Type f Caused by Acute Lower Leg Cellulitis.

    Science.gov (United States)

    Usui, Yuko; Kakuta, Risako; Araki, Makoto; Sato, Taigo; Gu, Yoshiaki; Yano, Hisakazu; Taniuchi, Norihide

    2016-01-01

    In Japan, routine Haemophilus influenzae type b (Hib) vaccination began in 2013. Thus, similar to other countries, a strain shift is expected in the near future. We experienced a case of H. influenzae type f (Hif) bacteremia in a 66-year-old man. The primary focus of the infection was the soft tissue of the left lower leg, which is an extremely rare origin in adults. Subsequently, we conducted multilocus sequence typing and identified the strain as sequence type 124, which is the most common invasive strain of Hif worldwide. This case may mark the beginning of an Hif strain shift in Japan. PMID:27374690

  19. Draft Genome Sequence of Nocardia jinanensis, an Opportunistic Bacterial Pathogen That Causes Cellulitis

    Science.gov (United States)

    Chakrabortti, Alolika; Li, Jinming

    2016-01-01

    The draft genome sequence of Nocardia jinanensis, an opportunistic pathogen that can cause skin infections, reveals genes that may contribute to the lifestyle and pathogenicity of N. jinanensis. The genome also reveals the biosynthetic capacity of N. jinanensis in producing mycolic acids, siderophores, and other polyketide and nonribosomal peptide-derived secondary metabolites. PMID:27445366

  20. Trasduzione del segnale e poliamine nell'apoptosi di cellule cardiache

    OpenAIRE

    Cetrullo, Silvia

    2009-01-01

    Introduction: Apoptotic cell death of cardiomyocytes is involved in several cardiovascular diseases including ischemia, hypertrophy and heart failure, thus representing a potential therapeutic target. Apoptosis of cardiac cells can be induced experimentally by several stimuli including hypoxia, serum withdrawal or combination of both. Several lines of research suggest that neurohormonal mechanisms play a central role in the progression of heart failure. In particular, excessive activatio...

  1. Detection de produits de fission a l'aide de cellules photovoltaiques

    Science.gov (United States)

    Liatard, E.; Akrouf, S.; Bruandet, J. F.; Fontenille, A.; Glasser, F.; Stassi, P.; Chan, Tsan Ung

    1988-04-01

    The response of photovoltaic cells to heavy ions and fission products have been tested in-beam. Their main advantages are their extremely low price, their low sensitivity to energetic light ions with respect to fission products, and the possibility to cut and fit them together to any shape without dead zone. The time output signals of a charge sensitive preamplifier connected to these cells allows fast coincidences. A resolution of 12 ns (FWHM) has been measured between two cells.

  2. Orbital cellulitis in course of typhoid fever; Zapalenie tkanki oczodolowej w przebiegu duru brzusznego

    Energy Technology Data Exchange (ETDEWEB)

    Nowacka, K.; Szreter, M.; Mikolajewicz, J. [Centrum Zdrwowia Dziecka, Warsaw (Poland)

    1993-12-31

    In 18 months girl with exophthalmus of the left eye and extensive swelling of the soft tissues in both orbits during continued fever was observed. Typhoid fever with a non-typical course and ophthalmic complications were diagnosed on the basis of serological tests. Complete cure after treatment with augmenting was obtained. (author) 10 refs, 2 figs

  3. Orbital wall infarction mimicking periorbital cellulitis in a patient with sickle cell disease

    Energy Technology Data Exchange (ETDEWEB)

    Ozkavukcu, Esra; Fitoz, Suat; Erden, Ilhan [Ankara University School of Medicine, Department of Radiology, Ankara (Turkey); Yagmurlu, Banu [Kirikkale University School of Medicine, Department of Radiology, Kirikkale (Turkey); Ciftci, Ergin [Ankara University School of Medicine, Department of Paediatric Infectious Diseases, Ankara (Turkey); Ertem, Mehmet [Ankara University School of Medicine, Department of Paediatric Haematology, Ankara (Turkey)

    2007-04-15

    Orbital wall infarction and subperiosteal haematomas are unusual manifestations of sickling disorders. Here we report an 11-year-old girl with sickle cell anaemia having multiple skull infarctions including the orbital bony structures associated with subperiosteal haematomas. The diagnosis was made by MRI, which showed bone marrow changes and associated haemorrhagic collections. The patient was successfully managed without surgical intervention. (orig.)

  4. The radiation effects on the living cell; Les effets des rayonnements sur la cellule vivante

    Energy Technology Data Exchange (ETDEWEB)

    Sage, E.; Dutrillaux, B.; Soussi, Th. [Institut Curie, 75 - Paris (France)]|[Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France); Boiteux, S.; Lopez, B. [CEA-CNRS/Fontenay-aux-Roses, 92 (France); Feunteun, J. [Institut Gustave Roussy, 94 - Villejuif (France)

    1999-06-01

    This publication is a presentation of particular points discussed during the colloquium of the 15-18 june 1999, for which scientific researches are performed at the CEA/CNRS. They deal with the radiobiology, for the radiation effects on living matter; with the DNA, for the knowledge and repair mechanisms on cells submitted to ionizing radiations; with the exposition to UV in correlation with neoplasms; with the P53 gene which is a tumour suppressor. (A.L.B.)

  5. Optimisation du rendement des cellules photovoltaiques à heterojonctions GaInP/GaAs

    OpenAIRE

    DJERIOUAT, Khadidja

    2011-01-01

    La consommation d’énergie est nécessaire au développement social et économique. Ces médiocrités rappellent l’extrême importance de la maîtrise énergétique : savoir créer de l’énergie, savoir l’économiser aussi, il y a un compromis entre la production et la consommation et par suite il faut entrer dans une logique forte d’économies d’énergie et augmenter nettement la part des énergies renouvelables. La conversion photovoltaïque est la transformation directe d’une énergie électro...

  6. Neuroimaging findings in a child with dumbbell-shaped frontosphenoidal dermoid cyst presenting as preseptal cellulitis

    Energy Technology Data Exchange (ETDEWEB)

    Dizon, Mercedes; Ozturk, Arzu; Izbudak, Izlem [The Johns Hopkins Hospital, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Redett, Richard J. [Johns Hopkins University School of Medicine, Department of Surgery, Division of Plastic Surgery, Baltimore, MD (United States)

    2009-08-15

    We report the CT and MRI findings in a 5-year-old girl with histologically proven frontosphenoidal dumbbell-shaped dermoid cyst with sinus tracts in the frontal bone extending to the dura. Although the most common location for dermoid cyst in the head and neck is at the frontosphenoidal region, presentation with a tract extending deep to underlying bone or the intracranium is rare for this location. Complete surgical excision has been widely accepted as the basic treatment for dermoid cyst. However, the relatively extensive nature of such surgical interventions may be associated with serious risks to both visual acuity and cosmesis. From a clinical viewpoint, even if these are rare cases, radiological imaging is crucial for orienting the deeper extension of the lesion for presurgical planning. (orig.)

  7. Helmintos intestinales en aves Ciconiiformes de la ciénaga de Chuburná, Yucatán, México

    OpenAIRE

    Alfredo O. Barrera-Guzmán; Sergio Guillén-Hernández

    2008-01-01

    Se recolectaron aves Ciconiiformes en la ciénaga de Chuburná, Yucatán y los intestinos de las aves fueron examinados en busca de parásitos helmintos. En total se encontraron 7 taxa de helmintos: 4 digéneos, 2 nematodos y 1 acantocefalo. Por vez primera se registra para Yucatán el digéneo Cotylotretus grandis y se registran nuevos hospederos para las especies de helmintos Euhaplorchis californiensis y Southwellina hispida, así como para el género Ascocotyle.

  8. Análisis y aplicación de estrategias para modular la respuesta inflamatoria en patologías intestinales

    OpenAIRE

    Orsini Delgado, María Lucía

    2016-01-01

    Durante las últimas décadas se ha reportado un importante incremento en la incidencia de patologías inmunes inflamatorias, no infecciosas, fundamentalmente en países desarrollados o en vías de desarrollo. Debido a la velocidad con que se ha incrementado la incidencia de estas patologías, sólo los cambios en los factores ambientales son capaces de explicarlo. Estudios epidemiológicos han permitido observar una asociación entre el incremento en patologías inflamatorias no infecciosas y la dismi...

  9. Characterization and pharmacological modulation of intestinal inflammation induced by ionizing radiation; Caracterisation et modulation pharmacologique de l'inflammation intestinale induite par les rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Gremy, O

    2006-12-15

    The use of radiation therapy to treat abdominal and pelvic malignancies inevitably involves exposure of healthy intestinal tissues which are very radiosensitive. As a result, most patients experience symptoms such as abdominal pain, nausea and diarrhea. Such symptoms are associated with acute damage to intestine mucosa including radio-induced inflammatory processes. With a rat model of colorectal fractionated radiation, we have shown a gradual development of a colonic inflammation during radiation planning, without evident tissue injury. This radio-induced inflammation is characterized not only by the sur expressions of pro-inflammatory cytokines and chemokines, a NF-kB activation, but also by a repression of anti-inflammatory cytokines and the nuclear receptors PPARa and RXRa, both involved in inflammation control. This early inflammation is associated with a discreet neutrophil recruitment and a macrophage accumulation. Macrophages are still abnormally numerous in tissue 27 weeks after the last day of irradiation. Inflammatory process is the most often related to a specific immune profile, either a type Th1 leading to a cellular immune response, or a type Th2 for humoral immunity. According to our studies, a unique abdominal radiation in the rat induces an ileum inflammation and an immune imbalance resulting in a Th2-type profile. Inhibiting this profile is important as its persistence promotes chronic inflammation, predisposition to bacterial infections and fibrosis which is the main delayed side-effect of radiotherapy. The treatment of rats with an immuno-modulator compound, the caffeic acid phenethyl ester (C.A.P.E.), have the potential to both reduce ileal mucosal inflammation and inhibit the radio-induced Th2 status. In order to search new therapeutic molecular target, we has been interested in the PPARg nuclear receptor involved in the maintenance of colon mucosal integrity. In our abdominal irradiation model, we have demonstrated that the prophylactic treatment with a PPARg synthetic ligand, the so-called 5-aminosalicylic acid (5-ASA), protects against the development of the acute mucosal colon inflammation. This pharmacological drug restrains radio-induced expression of pro inflammatory molecular actors such as TNFa, MCP-1 and iNOS, it also limits the repression of nuclear receptors involved in inflammation control such as PPARg, and reduces the radio-induced accumulation of macrophages. These results could give some leads to find therapeutic drug to limit radio-induced early mucosal and consequently, to improve patients' comfort during and after the radiotherapy schedule. (author)

  10. Retinol, estado del hierro, malaria y parásitos intestinales: relación por medio de las citocinas TH1/TH2

    OpenAIRE

    Viviana Taylor; Claudia Velásquez; Luis C. Burgos; Jaime Carmona; Adriana Correa; Amanda Maestre; Rosa Uscátegui

    2008-01-01

    Introducción: La malaria, la anemia y la parasitosis intestinal coexisten y constituyen problemas de salud pública en Colombia. Datos disponibles en la literatura biomédica llevan a pensar que estos problemas no son aislados sino que están interrelacionados. Por otra parte, los suplementos de retinol han sido efectivos para reducir la mortalidad infantil, con disminución de complicaciones en niños palúdicos, posiblemente por efectos del retinol sobre la función inmune, desviando la respuesta ...

  11. Caracterización de parásitos intestinales asociados a la infección por VIH en Guinea Ecuatorial

    OpenAIRE

    Roka Elobo, Margarita; Goñi Cepero, María Pilar; Clavel Parrilla, Antonio

    2012-01-01

    Introducción El programa conjunto de las Naciones Unidas sobre el VIH/SIDA, ONUSIDA, estimó que en 2009, 33,3 millones de personas vivían con el VIH, de las cuales 22,5 millones correspondían a África Subsahariana. El 69% de nuevas infecciones por el VIH en el mundo y 1,3 millones de fallecimientos por causas relacionadas con el SIDA aparecen en esta Región. (UNAIDS, 2009). En Guinea Ecuatorial, la seroprevalencia de VIH en población adulta es del 5,2%, por lo que ha sido catalogado por ONUS...

  12. Fitoterapia Mbyá-Guaraní en el control de las parasitosis intestinales. Un estudio exploratorio con Chenopodium ambrosioides L. var. anthelminticum en cinco comunidades de Misiones, Argentina

    Directory of Open Access Journals (Sweden)

    Gabriela Navone

    2015-07-01

    Full Text Available En las comunidades Mbyá-Guaraní, el conocimiento local de las especies vegetales que habitan el “monte” se pone de manifi esto en el desarrollo de distintas actividades tales como su empleo medicinal en las parasitosis y dolencias asociadas. El objetivo de esta contribución fue evaluar la eficacia deChenopodium ambrosioidesL. var.anthelminticum(Ka´aré en el control de las enteroparasitosis. El estudio fue realizado durante septiembre de 1998 y abril de 1999 en las comunidades de Marangatú (MA, Ñamandú (ÑA, El Pocito (PO, Tabay (TB y Takuapí (TA del Departamento Libertador General San Martín, Misiones, Argentina. La muestra incluyó 148 personas que fueron agrupadas por sexo e intervalos etáreos. El tratamiento fitoterapéutico consistió en la administración de tintura de Ka´aré (maceración en alcohol etílico al 70%. El análisis coproparasitológico se realizó mediante examen directo y la técnica de enriquecimiento por flotación (Füllerbon previo y posterior al tratamiento con el Ka´aré. Los resultados indicaron altos porcentajes de individuos parasitados previo al tratamiento (PRET que fluctuaron entre 73.5% y 91.7%. Entre los protozoosEntamoeba colifue la especie más prevalente con porcentajes entre 18.4% y 37.5%.Hymenolepis nanaentre los cestodes presentó prevalencias entre 4.2% y 20.8%. Entre los nemátodosAncylostoma duodenale/Necator americanus(Ancylostomideos fue la más frecuente y su prevalencia fluctuó entre 55.1% y 83.3%.Trichuris trichiurasólo fue observado en ÑA y con una prevalencia muy baja (3.8%. El porcentaje de monoparasitismo fue mayor en ÑA (56.5%, el de biparasitismo en MA y TA (44.4%, mientras que el de poliparasitismo en TB (36.8%. En la evaluación postratamiento (POST la prevalencia total de parasitosis descendió respecto del pretratamiento (79.7% vs 68.9% (X2 Yates = 4.57; p E. coli(30.8%-0.0% y Ancylostomídeos (52.0%-11.5%. Así, en ÑA los Ancylostomídeos mostraron diferencias estadísticamente signifi cativas (73.1% vs. 11.5% (X2 Yates = 8.99; p Ascaris lumbricoidesdescendió en los individuos de todas las comunidades, siendo más evidente en PO (20.8% vs. 0.0% y en ÑA (19.2% vs. 0.0%. ParaGiardia lamblia,H. nanayStrongyloides stercoralisel tratamiento fitoterapeútico no fue efectivo. Respecto al monoparasitismo se observó que sólo disminuyó levemente en TA (44.4% vs. 43.2% y aumentó en el resto de las comunidades, siendo mayor el aumento de monoparasitados en ÑA (56.5% vs. 76.9%. Sin embargo el porcentaje de biparasitismo disminuyó en la mayoría de las comunidades estudiadas, con excepción de TB (36.8% vs. 50.0%. Por último el poliparasitismo descendió sólo en TB (36.8% vs. 11.1% y ÑA (17.4% vs.7.7%. Los resultados obtenidos demostraron la efectividad deCh. ambrosioidesL. var.anthelminticumsobre los Ancylostomideos yA. lumbricoides, mientras que para protozoos, cestodes y larvas deS. stercoralisno fue efectivo.

  13. Retrospektive Analyse der parasitologischen Untersuchungsergebnisse eines privaten Untersuchungslabors : Intestinale, respiratorische und vektorübertragene Parasitosen bei Hunden und Katzen in Deutschland (2004 – 2006)

    OpenAIRE

    Globokar Vrhovec, Majda

    2013-01-01

    Es wurden Untersuchungsbefunde von Kotproben, die einem kommerziellen tierärztlichen Untersuchungslabor von Tierärzten in den Jahren 2004–2006 zugesandt worden waren, ausgewertet. Somit konnten aktuelle Daten die Häufigkeit des Vorkommens von Parasitosen des Verdauungs- und Atmungstrakts bei Hunden und Katzen in Deutschland liefern. Bei Hunden wurden mittels ZnCl2-NaCl-Flotationsverfahren Toxocara-Eier in 4,6 %, Oozysten von Isospora spp. (Isospora canis, Isospora burrowsi/ohioensis) in 4,5 %...

  14. Der Einfluss phytogener Futterzusatzstoffe auf die Nährstoffverdaulichkeit und Aktivität verschiedener intestinaler Enzyme sowie Expression von Nährstofftransportern bei Absetzferkeln

    OpenAIRE

    Krämer, Carolin

    2014-01-01

    In the present study, the influence of a phytogenic feed additive, two polyphenol-rich apple extracts and four phytogenic substances on the adhesion between an enteropathogenic E. coli and an IPEC-J2-cell line was examined. In a feeding trial, 24 female and 24 castrated male piglets (weaned at the age of 28 days) were assigned to four feeding groups in two successive series of experiments. The starter diet contained 0.2 % wheat bran in the control group A, 0.2 % fenugreek seeds in group B...

  15. Retinol, estado del hierro, malaria y parásitos intestinales: relación por medio de las citocinas TH1/TH2

    Directory of Open Access Journals (Sweden)

    Viviana Taylor

    2008-09-01

    Full Text Available Introducción: La malaria, la anemia y la parasitosis intestinal coexisten y constituyen problemas de salud pública en Colombia. Datos disponibles en la literatura biomédica llevan a pensar que estos problemas no son aislados sino que están interrelacionados. Por otra parte, los suplementos de retinol han sido efectivos para reducir la mortalidad infantil, con disminución de complicaciones en niños palúdicos, posiblemente por efectos del retinol sobre la función inmune, desviando la respuesta de citocinas hacia un patrón TH2, que también protege de desarrollar anemia grave. Esta revisión tiene como objetivo describir parte de las relaciones vistas en la literatura biomédica mundial, entre retinol y malaria, retinol y anemia, retinol, malaria y parasitosis intestinal, anemia y malaria y mostrar la mediación de estas interrelaciones por el patrón de citocinas TH1/TH2 en sujetos con malaria.Metodología: Se consultaron las siguientes bases de literatura biomédica: Medline, Lilacs, Spingerlik, Md Consultant, Web of Science, Ovid, Scient Direct, Ebsco y Cochrane. También se buscó información para documentar la prevalencia de desnutrición, deficiencia subclínica de retinol, anemia y malaria en niños colombianos, lo mismo que sobre el papel antinfeccioso del retinol.Resultados: Existe asociación entre parasitosis intestinal y malaria; algunos estudios indican que los helmintos predisponen a contraer malaria en niños. De otro lado, los parásitos mencionados, también se han relacionado con anemia y bajas concentraciones plasmáticas de retinol, que a la vez se asocian con malaria. Sin embargo, no se encontró información que relacione simultáneamente todos estos tópicos y que muestre la respuesta de citocinas TH1/TH2 como la articulación de todos ellos.Conclusiones: Aclarar las múltiples interacciones entre malaria, anemia, parasitosis intestinal y deficiencia subclínica de retinol, teniendo como eje central la respuesta de citocinas TH1/TH2, es crítico para orientar acciones tendientes a su prevención y manejo.

  16. Gestion de cellules des systèmes électriques intégrant des sources de production stochastiques

    OpenAIRE

    Costa, Luis

    2008-01-01

    Energy supply and climate change are nowadays two of the most outstanding problems which societies have to cope with under a context of increasing energy needs. Public awareness of these problems is driving political willingness to take actions for tackling them in a swift and efficient manner. Such actions mainly focus in increasing energy efficiency, in decreasing dependence on fossil fuels, and in reducing greenhouse gas emissions. In this context, power systems are undergoing important ch...

  17. Intérêt des cellules souches mésenchymateuses dans la thérapie du glaucome

    OpenAIRE

    Roubeix, Christophe

    2014-01-01

    Glaucoma is a sight-threatening retinal neuropathy associated with elevated intraocular pressure (IOP) due to degeneration and fibrosis of the trabecular meshwork (TM). Glaucoma medications aim to reduce IOP without targeting the specific TM pathology, which could explain treatment failure observed in some cases. Bone-marrow mesenchymal stem cells (MSCs) are used today in various clinical studies to treat various degenerative processes. Here, we investigated the potential of MSC therapy in an...

  18. La transplantation d'ilots de Langerhans ou de cellules B: un pas vers la guerison du diabete?

    OpenAIRE

    Philips, Jean-Christophe; RADERMECKER, Régis; Scheen, André

    2003-01-01

    Diabetes mellitus places an enormous burden on patients, their relatives and the society. Current therapies do not provide sufficiently tight control of blood glucose to avoid diabetic complications. Some recent developments try to restore normal glucose homeostasis. Research is islet and stem cell transplantation is developing rapidly and this article summarizes the new approaches that could cure and not simply treat diabetes in the future.

  19. Pathology Image Of the Month: Rapidly Progressive Hemorrhagic Cellulitis of Bilateral Lower Extremities with Subsequent Septic Shock and Death.

    Science.gov (United States)

    Connor, Ellen E; Jackson, Nicole R; McGoey, Robin R

    2016-01-01

    A 51-year-old man presented to a community based emergency department with bilateral lower extremity swelling that began four days prior and that had evolved into recent blister formation on the left lower extremity. Medical history was significant only for hypertension and a recent self-described episode of "food poisoning" five days earlier characterized by diarrhea, nausea, and vomiting that quickly resolved. Physical exam revealed marked bilateral lower extremity edema and an ecchymotic rash below the knee. In addition to the rash, there were large flaccid bullae on the left leg, mostly intact but some notable for draining of scanty serosanguinous fluid. The patient was tachycardic with a rate of 114 bpm and initial labs showed thrombocytopenia (platelets 56 x 103/uL [140-440 x 103/uL]), hypoglycemia (15mg/dl [70-105mg/dl]), an elevated creatinine (2.7mg/dL [0.7- 1.25mg/dL]), and aspartate aminotransferase (AST 156U/L [5- 34U/L]). Two sets of blood cultures were drawn, broad spectrum antibiotics including doxycycline were empirically initiated and then he was subsequently transported to a tertiary care hospital for escalation of care. Within hours of presentation to the tertiary care facility, the rash appeared progressively hemorrhagic and bullous, lactic acidosis and coagulopathy developed and hemodynamic instability and septic shock necessitated endotracheal intubation and vasopressors. He was taken to the operating room for skin debridement but was emergently converted to bilateral above the knee lower extremity amputations due to the extent of the soft tissue necrosis. The patient remained intubated and in critical condition following surgery and the ecchymotic rash reappeared at the amputation sites. A newly developed ecchymotic rash with bullae formation was noted on the right upper extremity forearm. At that time, the clinicians were notified that four out of four blood culture bottles from admission were rapidly growing a microorganism. The family elected for withdrawal of care, and the patient died approximately 72 hours following presentation. A full and unrestricted autopsy was authorized by the Coroner's Office. PMID:27389382

  20. Quantification des cellules viables de P. phosphoreum dans les pavés de saumon cru par PCR temps reel

    DEFF Research Database (Denmark)

    Macé, Sabine; Mamlouk, Kelthoum; Chipchakova, Stoyka;

    de 350 pb sur le gène de la gyrase subunit B de P.phosphoreum. Leur spécificité a été démontrée en utilisant l’ADN de 88 souches bactériennes de 52 espèces bactériennes différentes. En utilisant ces amorces pour quantifier une culture pure de P.phosphoreum, une bonne corrélation (R2 de 0.99) a été...

  1. Effects of yeast extract and vitamin D on turkey mortality and cellulitis incidence in a transport stress model.

    Science.gov (United States)

    We evaluated yeast extract (YE) and vitamin D (VD) in turkeys treated with dexamethasone (Dex) at intervals designed to simulate transport stress during a 3 stage growout. YE but not VD decreased early mortality (P = 0.001) and mortality at wk 7 (P= 0.02) and wk 12 (P = 0.002) but not wk 16. Celluli...

  2. Quantum Dots pour le Ciblage en Cellules Vivantes et la Microscopie HiLo Bi-couleur

    OpenAIRE

    Muro, Eleonora

    2011-01-01

    Les Quantum Dots (QDs) sont des nanocristaux de semiconducteurs qui possèdent des propriétés optiques hors du commun. Leur utilisation comme sondes en biologie nécessite leur solubilisation dans l'eau, grâce à une chimie de surface adaptée, qui influence la taille finale du QD, ses propriétés optiques et son interaction avec l'environnement biologique. Nous avons développé un nouveau ligand, l'acide dihydrolipoïque-sulfobétaïne (DHLA-SB), qui permet d'obtenir des QDs à la fois petits, stables...

  3. Synthèse de nouveaux types de nanocristaux semi-conducteurs pour application en cellules solaires

    OpenAIRE

    De Kergommeaux, Antoine

    2012-01-01

    In order to be cost-effective, photovoltaic energy conversion needs to improve the solar cell efficiencies while decreasing the production costs. Nanocrystal based solar cells could fulfil these requirements through solution-processing, band gap and energy level engineering. PbS nanocrystal thin films already proved their potential for use as solar cell active materials with power conversion efficiencies approaching 7%. However, since lead based compounds are not compatible with European regu...

  4. Attività antiproliferativa e proapoptotica di bifenili relazionabili alla struttura della curcumina su cellule di melanoma maligno

    OpenAIRE

    PISANO, MARINA; Cossu, Sara; Fabbri, Davide; Dettori, Maria Antonietta; Sassu, Ilaria; Palmieri, Giuseppe; Delogu, Giovanna; Rozzo, Carla

    2008-01-01

    La curcumina è l’ingrediente attivo delle radici della Curcuma Longa ed è uno dei fitochimici più studiati al mondo per le sue proprietà antiossidanti, antinfiammatorie ed antitumorali. Nell'ambito della ricerca di nuovi agenti terapeutici contro il melanoma maligno (MM) abbiamo caratterizzato l’attività antiproliferativa sia della curcumina (D1) che di alcuni bifenili, strutturalmente riconducibili ad essa, su colture cellulari primarie di MM.

  5. ETUDE DE L’EFFET DU CADMIUM SUR LA CROISSANCE ET L’INTEGRITE DE LA CELLULE CHEZ DUNALIELLA SALINA .

    Directory of Open Access Journals (Sweden)

    A. ELLAFI

    2013-09-01

    Full Text Available The present study aims to evaluate changes in the kinetics of cell growth and pigment synthesis and morphological changes of the algae in the presence of different doses of cadmium in the culture medium.Growth kinetics was evaluated by counting cells, the pigment content by UV-Visible spectrophotometry, morphological variation by flowcytometry and by taking pictures of the light microscope. Our results show that cadmium causes a marked reduction in cell growth.Indeed, growth is reduced by 26% and 30% in the presence of 1 and 2μM, respectively, and the lethal dose is greater than 8 μM.However, the algae seems to acquire an adaptation strategy since we recorded a judgment of the cell death 3 days after the addition of Cd 8μM. Indeed,the instantaneous rate of growth becomes zero in the presence of Cd8μM due to a reduction in cell density of 0.587millions cells / ml / day, which lasted 3 days. For higher doses 8μM,the cellular metabolism down or zero, indicating a slowdown / stopcellular activity.Cd case, in addition, a decrease in the chlorophyll content of 85% in the presence of 8μM. Under these conditions, an increase in the content of carotenes whose content reaches 236% that of the control, indicating the acquisition of a defensive strategy by Algae: The Way of xanthophylls.

  6. Construction de nouveaux Bodipys solubles pour la concentration d'énergie et les cellules photovoltaïques

    OpenAIRE

    Bura, Thomas

    2013-01-01

    The work undertaken during this PhD was focused on the design of fluorophores for several applications in fluorescence or energy conversion device. Several compounds from the Bodipy and Triazatruxene families were synthesized, characterized and studied. By structural modifications brought to these molecules, it was possible to obtain a panel of compounds those posses a range of absorption and emission properties which extend from 500 to 800 nm. The modulation of these optical properties has a...

  7. Reprogrammation épigénétique des cellules hôtes par Legionella pneumophila

    OpenAIRE

    Rolando, Monica; Rusniok, Christophe; Margueron, Raphael; Buchrieser, Carmen

    2013-01-01

    International audience Legionella pneumophila est un bacille à Gram négatif à l'origine d'une infection pulmonaire grave appelée légionellose (ou maladie du légionnaire) [11]. Les légionelles sont des bactéries vivant en milieu aquatique et affectionnant particulièrement les eaux tièdes. Ce sont des bactéries intracellulaires facultatives qui colonisent habituellement les amibes, protozoaires qui prolifèrent dans l'eau, mais elles sont également capables d'infecter l'homme par le biais d'a...

  8. Evaluation of three coproparasitoscopic techniques for the diagnosis of intestinal geohelminthiases = Evaluación de tres técnicas coproparasitoscópicas para el diagnóstico de geohelmintos intestinales

    OpenAIRE

    Restrepo Von Schiller, Isabel Cristina; Mazo Berrío, Liliana Patricia; Salazar Giraldo, Mary Luz; Montoya Palacio, Martha Nelly; Botero Garcés, Jorge Humberto

    2013-01-01

    Introduction: Soil transmitted helminths (geohelminthiases) are a worldwide public health problem. However, no reference technique (gold standard) for their diagnosis has been established; contrariwise, several coproparasitoscopic tests, with variable sensibility rates, have been used. Objective: To compare the sensibility of the coproparasitoscopic Kato-Katz technique with that of the combination of direct coprologic examination and Ritchie`s concentration, for the detection of geohelminth...

  9. Intestinal parasitoses and environmental factors in a rural population of Argentina, 2002-2003 Parasitosis intestinales y factores ambientales en una población rural de Argentina, 2002-2003

    OpenAIRE

    Juan A. Basualdo; Córdoba, María A; de Luca, María M; María L. Ciarmela; Betina C. Pezzani; María S. Grenovero; Marta C Minvielle

    2007-01-01

    We evaluate the prevalence of intestinal parasites in 504 people and the degree of association between environmental variables and parasites found in population, soil and water in a rural area of Argentina during 2002-2003. A structured survey was used to evaluate the environmental variables and fecal-human, soil and water samples were analyzed. The prevalence of parasites was 45.4%. Most prevalent protozoa were Blastocystis hominis (27.2%) and Giardia lamblia (6.9%), while the most prevalent...

  10. L’azathioprine dans les maladies inflammatoires chroniques intestinales : impact de son métabolisme sur l’efficacité et la sécurité thérapeutique

    OpenAIRE

    Dewit, Olivier

    2012-01-01

    Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. TP metabolism is complex and many enzymes are involved. Among them, Thiopurine methyl transferase is the only one routinely measured by pheno- or genotyping. A decreased TPMT activity results in a potential overdosing of TP drugs leadin...

  11. Untersuchungen zur biotischen Bildung von Methylquecksilber aus anorganischem Quecksilber durch intestinale Sulfat-reduzierende Bakterien und die Bestimmung alkylierter Quecksilberverbindungen mittels GC-ICP-MS und Isotopenverdünnungsanalyse

    OpenAIRE

    Kaschak, Elisabeth

    2013-01-01

    Alkylierte Quecksilberspezies sind hundertfach toxischer als anorganisches Quecksilber (Hg) und werden in der Nahrungskette mit zunehmender Trophieebene im Gewebe von Tieren und dem Menschen akkumuliert. Aufgrund der Relevanz für die Umwelt und den Effekt auf die menschliche Gesundheit kommt der biotischen Transformation von anorganischem Hg zu Monomethylquecksilber (MeHg) eine große Bedeutung zu. Es ist bekannt, dass Sulfat-reduzierende Bakterien zu den Hauptproduzenten von MeHg gehören. Dar...

  12. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    OpenAIRE

    Teubner, Wera

    2005-01-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen...

  13. Effet de l'incorporation de graines de lin extrudées dans l'aliment de la truie sur la fonction de barrière intestinale du porcelet

    OpenAIRE

    de Quelen, Francine; Ferret-Bernard, Stéphanie; Mourot, Jacques; Boudry, Gaëlle

    2012-01-01

    The main objective of this study was to evaluate the effect of extruded linseed (rich in alpha‐linolenic acid, ALA) in the sow diet on the intestinal barrier function of piglets. Twelve sows (Large White x Landrace) were divided into two groups: the first one received a diet containing sunflower oil (ALA3 with ALA represented 3% of total fatty acids) and the second received a diet containing extruded linseed (ALA27 with 27% of ALA) during gestation and lactation. Intestinal paracellular perme...

  14. Charakterisierung von Sulfotransferasen im Gastrointestinaltrakt von Mensch und Ratte und Aktivierung von Promutagenen in V79-Zellen, die eine intestinale Form (1B1) des Menschen und der Ratte exprimieren

    Science.gov (United States)

    Teubner, Wera

    2001-05-01

    Die Ausstattung der gastrointestinalen Mukosa des Menschen und der Ratte mit Sulfotransferasen wurde mit Hilfe von Immunodetektion und Enzymaktivitätsmessungen untersucht. In Proben aus Colon und Rektum von 39 Personen wurden die Formen h1A1, h1A3 und h1B1 identifiziert, wobei in einer weiteren Probe, die als einzige von einem an Colitis Ulcerosa erkrankten Patienten stammte, keine Sulfotransferasen nachgewiesen werden konnten. Bei der Immunblot-Analyse war das Expressionsmuster der einzelnen Formen in allen Proben ähnlich. In wenigen Proben waren die relativen Signalintensitäten der h1A1 und der h1B1 um die Hälfte erniedrigt. Der Gehalt von SULT an zytosolischem Protein zeigte einen bis zu 8 - 10fachen Unterschied, er betrug jedoch bei zwei Dritteln der Proben zwischen 0,15 und 0,3 (h1A1 und h1A3) bzw. 0,6 und 0,8 Promille (h1B1). Die Variation konnte nicht auf Alter, Geschlecht oder Krankheitsbild der Patienten zurückgeführt werden. Auch der für die allelischen Varianten der h1A1 beschriebene Effekt auf die Enzymaktiviät bzw. Stabilität konnte in der Menge an immunreaktivem Protein nicht in diesem Ausma detektiert werden. Die Allelhäufigkeit von h1A1*R und h1A1*H war gegenüber der gesunden Bevölkerung nicht verändert. In den sieben Proben aus dem Dünndarm (Coecum, viermal Ileum, Jejunum) konnten zusätzlich die Formen h1E1 und h2A1 identifiziert werden. Ein möglicherweise der Form h1C1 entsprechendes Protein wurde im Magen detektiert. Im Vergleich zum Menschen war die Expression in der Ratte stärker auf die Leber konzentriert. Während beim Menschen in allen untersuchten Abschnitten Sulfotransferasen in Mengen detektiert wurden, die in zwei Fällen (h1B1 und h1A3) sogar den Gehalt in der Leber überstiegen, beschränkte sich die Expression in der Ratte auf im Vergleich zur Leber geringe Mengen im Magen und Dickdarm. Nachgewiesen wurden die r1B1, r1A1 sowie eine nicht identifizierte Form von 35kD, bei der es sich vermutlich um die r1C2 handelt. Im Vergleich zur Leber enthielt der Dickdarm der Ratte 20 - 30 % an r1B1 und 3 % an r1A1, während im Dickdarm des Menschen die 3 - 5fache Menge an h1B1 und 25 - 50 % an h1A1 gefunden wurden. Die nicht identifizierte Form verhielt sich wie die r1B1. Die für die Leber der Ratte bekannte geschlechtsabhängige Expression wurde im Gastrointestinaltrakt nicht beobachtet. Die Verteilung der Sulfotransferasen im Colon und Ileum des Menschen wurde immunhistochemisch untersucht; für die Gewebe der Ratte war die Spezifität der zur Verfügung stehenden Antiseren nicht ausreichend. Im Colon traten h1B1-spezifische Färbungen in den differenzierten Enterozyten am oberen Ende der Krypten auf, im Dünndarm wurden die Epithelzellen der Zotten gefärbt. Die Färbung konzentrierte sich auf das Zytoplasma. Eine ähnliche Verteilung zeigte sich für h1A1 und h1A3, auer da zusätzlich eine intensive Färbung der Endothelzellen der Kapillaren in der Submukosa des Ileums auftrat. Im Dickdarm war dies nur bei den Kapillaren in den Lymphfollikeln zu erkennen. Die h2A1 war lediglich im Zytoplasma der Epithelzellen der Zotten des Ileums nachzuweisen, während im Colon keine Farbreaktion auftrat. Durch die Verwendung der rekombinanten Indikatorstämme TA1538-h1A1, -h1A3 und -h1B1 und des Ausgangsstammes Salmonella typhimurium TA1538 im Ames-Test wurde gezeigt, da verschiedene benzylische und allylische Alkohole durch im humanen Colon exprimierte Sulfotransferasen zu Mutagenen aktiviert werden. In den meisten Fällen erwies sich eine der drei Sulfotransferasen als besonders effizient in der Bioaktivierung, während durch die anderen Formen kein oder nur ein schwacher Effekt verursacht wurde. Die Bioaktivierung von Promutagenen durch Sulfotransferasen im Colon mu im Zusammenhang mit der Lokalisation diskutiert werden. Die Zellen im Darm, in denen immunhistochemisch Sulfotransferasen detektiert wurden, haben mit Ausnahme des Endothels je nach Abschnitt eine Lebensdauer von maximal fünf Tagen und machen keine weiteren Zellteilungen mehr durch. Daher sind DNA-Schäden in diesen Zellen ein sehr geringes Risiko für den Organismus. Soweit die reaktiven Metabolite in diesen Zellen gefangen bleiben, kann die Bioaktivierung in diesen Zellen und die Bildung von Addukten als protektiv betrachten werden, da letztere nach wenigen Tagen mit den toten Zellen in das Darmlumen abgegeben werden. Für den Vergleich der Bioaktiverung von Promutagenen durch die Form 1B1 des Menschen und der Ratte wurden aus V79 Lungenfibroblasten des Chinesischen Hamsters abgeleitete Zellinien hergestellt, die je eine der beiden Formen stabil exprimieren. Damit standen 1B1-profiziente Indikatorzellen für den HPRT-Genmutationstest zur Verfügung, und die 1B1-abhängige Bioaktivierung konnte in einem System untersucht werden, die dem eukaryontischen Organismus näher steht als die für die Ames-Tests verwendeten Bakterien. So war z.B. die Sulfotransferase wie im Gewebe im Zytoplasma lokalisiert. Als Modellsubstanzen wurden hierbei die bereits in TA1538-h1B1 mutagen wirkenden benzylischen Alkohole 6-Hydroxymethylbenzo[a]pyren und 4-Hydroxycyclopenta-[def]chrysen getestet. Da die Sensitivität einer Sulfotransferase-exprimierenden V79-Zellinie sowohl durch die Menge an Sulfotransferase als auch durch die Verfügbarkeit des Sulfodonors limitiert sein könnte, wurden die Mutagenitätsexperimente mit V79-r1B1-Zellinien durchgeführt, die sich in ihrer Enzymaktivität um das Zwanzigfache unterschieden: V79-r1B1/A und -/B. Eine starke Erhöhung der Mutantenfrequenz wurde nur in der hoch exprimierenden Zellinie V79-r1B1/A (1019 ± 224 pmol/mg/min) beobachtet, so da eine gravierende Beeinträchtigung der Sensitivität durch einen Mangel an Kosubstrat ausgeschlossen wurde. In der niedriger exprimierenden Zellinie V79-r1B1/B (57 ± 9 pmol/mg/min) war nur mit 6-Hydroxymethylbenzo[a]pyren ein schwacher Anstieg der Mutantenfrequenz zu erkennen, der mit 0,3 µM bei einer in etwa 100fach höheren Konzentration begann als bei V79-r1B1/A. Die zytosolische Fraktion aus V79-r1B1/B-Zellen enthielt in etwa die dreifache Menge an r1B1-Protein wie die aus Colonmucosa der Ratte. Da zumindest für die humane Mukosa gezeigt wurde, da die 1B1 nur im einschichtigen Epithel, nicht aber in allen Zellen der Mukosa exprimiert wird, repräsentiert die zytosolische Fraktion aus der Mukosa nur bedingt die Expression in den Epithelzellen und der Vergleich mit den V79-1B1-Zellen ist grob. Im Gegensatz zu V79-r1B1/B war die Zellinie V79-h1B1, die ebenfalls nur mit Darm und Leber vergleichbare Mengen an h1B1 exprimierte, in der Lage, beide benzylischen Alkohole zu aktivieren. Der Erhöhung der Mutantenfrequenz im Vergleich zur KontrollZellinie war ähnlich wie bei der stark exprimierenden Zellinie V79-r1B1/A, erforderte aber 10fach höhere Konzentrationen. Somit unterscheiden sich Mensch und Ratte nicht nur insgesamt in ihrer Ausstattung des Gastrointestinaltrakts mit Sulfotransferasen, auch bei Betrachtung einer einzelnen Form zeigten sich deutliche Unterschiede in der Aktivierung von zwei Promutagenen. Die Ratte ist daher ein ungeeignetes Modell, um die Rolle von Sulfotransferasen bei tumorinitiierenden Prozessen im Darm zu untersuchen. Dies unterstreicht die Bedeutung von rekombinanten in-vitro-Systemen für die Erfassung des humanen Metabolismus von Fremdstoffen. Insgesamt kennt man nur eine geringe Anzahl von Substanzen, die im Tierexperiment Colontumore erzeugen, und mit Ausnahme der heterozyklischen aromatischen Amine sind diese lediglich von experimenteller Bedeutung. Dies spricht für effiziente Schutzmechanismen der Darmmukosa gegenüber Mutagenen und lät die Frage nach der hohen Inzidenz des Kolorektalkarzinoms offen. Cytosolic fractions of human and rat gastro-intestinal mucosa were electrophoresed, blotted and probed with six antibodies with differing specificities for sulfotransferase (SULT) forms. Using SULTs heterologously expressed in bacteria for comparison of electrophoretic and immunoreactive properties the following SULTs could be identified in the different parts of the human (h) gastro-intestinal tract: h1A1, h1A3 and h1B1 were detected in all parts analyzed (rectum, colon, caecum, ileum, jejunum, stomach), h1E1 and h2A1 only in the small intestine and h1C1 only in stomach. The presence of h2A1 and h1E1 in the small intestine was also confirmed by enzyme activity measurements using radiolabelled dehydroepiandrosterone and b-estradiol as substrates. SULTs were detected in almost all of the samples analyzed (rectum: 8 of 8, colon: 22 of 23, ileum 5 of 5 and one each of coecum, jejunum and stomach). The colon sample void of SULT protein was the only one taken from a patient suffering from ulcerative colitis. Using an antibody which crossreacts with all human SULT1 forms, a similar pattern of immunoreactivity was observed for all positive samples of rectum and colon mucosa. However, the total amount of immunoreactive protein varied 8 - 10 fold. SULT content in two thirds of the samples was between 0.15 and 0.3 ‰ (h1A1 and h1A3) and 0.6 and 0.8 ‰ (h1B1). This variation could neither be related to age, gender nor disease. The distribution of the allelic variants h1A1*Arg and h1A1*His was analyzed by restriction fragment length polymorphism and the allele frequency in patients suffering from colorectal carcinoma (n = 39) was found not to differ from the values published for normal population. The reduced enzyme activity and stability that has been described for h1A 1*His in platelats was not reflected in the amount of h1A1 protein in the samples of colon and rectum mucosa. Expression of h1A1 and h1A3 was approximately four times higher in ileum than in colon, whereas amounts of h1B1 were comparable in both parts of the intestine. Some of these forms were also expressed at similar, or higher levels in the liver. However, the level of h1B1 protein was higher in the gut than in the liver, and h1A3 was hardly expressed in liver. In rat (r), unlike human, SULTs were poorly expressed in the intestine. r1B1 and an unidentified immunoreactive protein of 35kD were found in the large intestine (rectum, colon, coecum), the proximal jejunum and glandular stomach. r1A1 protein was detected in the large intestine and forestomach. However, the highest levels of these forms in the intestine reached only 3% (r1A1) and 20% (r1B1 and 35kD-protein) of those detected in liver. Unlike in liver, SULT expression in the intestine was independent on gender. Immunohistochemical analysis of human colon and ileum using antibodies specific for either h1B1, h2A1 or all forms of h1A showed that all forms were expressed in the cytosol of the short-lived absorptive cells. In ileum, expression was restricted to villus cells with no staining of crypt cells; except for h1A forms, which were also detected in the endothelial cells of capillaries in the submucosa. In colon, h1B1 and h1A forms, but not h2A1 were detected in the upper third of the crypts. Sensitivities of the antibodies were insufficient for analysis of rat intestine. As 1B1 was the most prominent form in the intestine of both species, Ames tests and hprt gene mutation assays were performed using indicator cells constructed for heterologous expression of 1B1. 6-Hydroxymethylbenzo[a]pyrene and 4-hydroxycyclo-penta[def]chrysene were detected as strong mutagens in Salmonella typhimurium TA1538-h1B1 but neither in the SULT-deficient parental strain nor in bacteria expressing h1A1 or h1A3. Other benzylic or allylic alcohols were mutagenic in Salmonella typhimurium TA1538-h1A1 or h1A3, but not in the h1B1-expressing strain. For the mammalian system, one cell line with high 1B1 activity as determined by turnover of a-naphthol at 1µM and two cell lines with lower activity were established: V79-r1B1/A (1019 ± 224 pmol/mg/min), V79-r1B1/B (57 ± 9 pmol/mg/min) and V79-h1B1 (19 ± 5 pmol/mg/min). 1B1 expression in cytosolic fractions was comparable to rat liver and human colon for V79-r1B1/B and V79-h1B1 respectively. Subcellular distribution was analyzed by immunostaining of cultured cells fixed with methanol. Strong staining of the cytosol was observed in most, but not all of the V79-r1B1/A cells. No staining was observed in V79-r1B1/B, V79-h1B1 or the parental V79 cells. In all cell lines, expression was stable over at least 25 passages and could be detected after 24, 48 and 72 h of cultivation. Population doubling times were 13,1 ± 0.6 h for V79-h1B1 (n = 4), 14.1 ± 1.3 h for V79-r1B1/A (n = 6) and 14.1 ± 1.7 h (n = 3) for V79-r1B1/B. 6-Hydroxymethylbenzo[a]pyrene and 4-hydroxycyclopenta[def]chrysene were detected as strong mutagens in V79-1B1 cells, but not in SULT-deficient control cells. The effect was strong in V79-r1B1/A and V79-h1B1, but weak and occurring at higher concentrations in V79-r1B1/B. Comparing immunoreactivity in cytosolic fractions and fixed cells, h1B1 was expressed more strongly in colonic epithelial cells than in V79-h1B1. It is therefore probable that the compounds tested are also activated in the human gut; however, due to the cellular localization of the enzyme, differentiated cells may be affected primarily. Since these cells are discarded into the gut lumen after a few days and do not undergo further cell divisions, the risk of causing mutations should be low. This mechanism may lead to a presystemic elimination of dangerous compounds. For the study of SULT1B1 mediated mutagenicity in human intestine, rat is a poor model since rat 1B1 was much less capable of activating the benzylic alcohols and was also found to be present in this organ in lower amounts than the human form.

  15. Remoción de formas parasitarias intestinales en una laguna facultativa de estabilización en Lima, Perú Removal of intestinal parasitic forms in a facultative stabilization pond in Lima, Peru

    Directory of Open Access Journals (Sweden)

    José O. Iannacone

    2002-12-01

    Full Text Available The effectiveness of a waste stabilization pond, to remove intestinal helminth eggs and protozoan cysts was studied in San Martin de Porres, Lima, Peru. From September to October 2000 four collections of samples were performed from raw domestic wastewater and from contends of primary, secondary and tertiary ponds. A comparative study of performance of the concentrations methods of Ritchie and Faust was also done. The overall average removal of parasitic forms was as follow: 69.37% from raw water and primary pond; 48.34% from primary to secondary pond; 85.45% from secondary to tertiary pond and 97.69% from raw water to tertiary pond. There was no significant difference in the quantitative performance of Ritchic and Faust methods. Giardia duodenalis (Lambl, 1859 Alexeieff, 1914, Entamoeba coli (Gras, 1879 Casagrandi & Barbagallo, 1895 and Ascaris lumbricoides (Linnaeus, 1758 were detected with both methods. Three other parasites were detected only by Ritchie method: Taenia sp., Rodentolepis nana (von Siebold, 1852 Spasskii, 1954 and Trichuris trichiura (Linnaeus, 1771 Stiles, 1901 and only Faust detected Isospora belli Wenyon, 1923. Overall number of protozoa cysts was higher than the number of helminth eggs. At the end, wastewater had a concentration of 1.5 parasitic forms L¹ what is considered inappropríate for ultimate use in agriculture by current standards.

  16. Prevalencia de Parasitosis Intestinales y Factores Asociados en un Corregimiento de la Costa Atlántica Colombiana Prevalence of intestinal parasitism and associated factors in a village on the Colombian Atlantic Coast

    Directory of Open Access Journals (Sweden)

    Sonia Agudelo-Lopez

    2008-10-01

    Full Text Available Objetivos Determinar la prevalencia del parasitismo intestinal e identificar los factores de riesgo asociados a estos, en el corregimiento de Loma Arena, Departamento de Bolívar, Colombia Metodología Mediante encuesta aplicada a cada grupo familiar, fueron evaluadas las condiciones socio-sanitarias y educativas de la población. Para el estudio coproparasitológico se recolectó por cada persona, dos muestras de heces obtenidas por evacuación espontánea y en dos días diferentes. El análisis de las heces se realizó mediante un examen directo en solución salina fisiológica y coloración temporal con lugol y por el método de concentración formol-éter Resultados Se encontró que el 92 % de las personas estaban parasitadas, 92 % de ellas con al menos un patógeno. El poliparasitismo fue muy importante (89,2 % encontrándose hasta un máximo de 7 especies por hospedador. La coinfección de protozoarios y helmintos fue frecuente (64 %. Solo se encontró una frecuencia de teniosis de 0,9 %. Se observó una asociación significativa entre sintomatología y presencia de parásitos (pObjectives Determining the prevalence of intestinal parasitism and identifying the associated risk factors in the village of Loma Arena, Bolivar department, Colombia. Methodology The community's sanitary and educational conditions were evaluated by using a questionnaire which was applied to each family group. Two stool samples obtained by spontaneous evacuation, on two different days, were gathered from each participating person for the coproparasitological study. The coprological test involved direct examination in saline physiological solution and temporary staining with Lugol's solution and the formol-ether concentration method. Results It was found that 92 % of the population was parasitised, 92 % of them with at least one pathogenic parasite. Polyparasitism was very important (89,2 %; a maximum of 7 species per host was found. Helminth and protozoa coinfection was frequent (64 %. There was only 0,9 % teniosis prevalence. There was a significant association between symptomatology and parasite presence (p< 0.05, though such relationship was not seen with potentially pathogenic parasites (with the exception of Trichuris trichura and abdominal pain. The statistical analysis did not reveal any relationship between parasitism and educational level or sanitary habits. Conclusion The uniform distribution of most intestinal parasites amongst the five age-groups evaluated showed that people in Loma Arena were evenly exposed to sources of infection in all age-groups.

  17. Expresión local de citocinas, grado de lesión de la mucosa gástrica e influencia de las helmintiasis intestinales en adultos venezolanos infectados por "Helicobacter pylori"

    OpenAIRE

    Fuenmayor Boscán, Alisbeth Diamelis

    2012-01-01

    De este trabajo de investigación sobre la expresión de citocinas en el epitelio y la lámina propia de la mucosa gástrica antral, el grado de lesión tisular en individuos infectados por H. pylori y el análisis de su posible modulación por la helmintiasis intestinal, se concluye que: La infección gástrica por H. pylori incrementa la expresión de las citocinas proinflamatorias IL-1[beta] y TNF-[alfa] en el epitelio y en la lámina propia de la mucosa antral con respecto a los sujetos no infectado...

  18. Evaluación de la expresión de las proteínas PPARγ Y NFκB en vellosidades intestinales de ratones adultos ICR infectados con rotavirus ECwt y tratados con pioglitazona

    OpenAIRE

    Gómez Moreno, Dory Lineth

    2013-01-01

    ANTECEDENTES Rotavirus es la principal causa de diarrea severa en niños menores de cinco años de edad en todo el mundo, según la OMS, rotavirus causa aproximadamente 527.000 muertes cada año (1). Dos vacunas de rotavirus vivos atenuados (Rotarix ™) y (RotaTeq ™) están disponibles actualmente (2). Aunque estas vacunas han demostrado su eficacia, no evita la aparición de los síntomas y muchos niños permanecen sin vacunar. Por consiguiente, se necesitan alternativas farmacológicas para el tra...

  19. Prevalencia de parásitos intestinales en escolares de la Escuela Básica Estadal José Félix Blanco, estado Bolívar, Venezuela.

    Directory of Open Access Journals (Sweden)

    Rodolfo Devera

    2010-12-01

    Full Text Available Intestinal parasitism in school-age children is one of the main medical problems In Venezuela. The prevalence of these infections is variable, but, in general, it is higher in school children. The objective of this study was to determine the prevalence of intestinal parasites in school children enrolled in the State Primary School Jose Felix Blanco, San Felix, Bolivar State, Venezuela. 274 children, between 6 and 15 years of age, were evaluated in February, 2006. A stool sample of each student was collected and analyzed by means of spontaneous sedimentation and formol-ether techniques. The prevalence of enteroparasites was 62.6% (174/278. No difference in age (X2= 2.388 f.d. = 4 p > 0.05 or gender (p > 0.05 was observed in the affected group. Eleven species of parasites and/or commensals were diagnosed. Among protozoan, Blastocystis hominis (44.6% and Giardia lamblia (12.6%; and among helminths, Ascaris lumbricoides (15.5% and Trichuris trichiura (11.5% were the most common. In conclusion, a high prevalence of intestinal parasitism was found in the sample of school children evaluated, with predominance of protozoan, mainly B. hominis

  20. Estudio experimental del comportamiento y cicatrización de las anastomosis intestinales (colónicas) efectuadas en condiciones de isquemia con especial atención a la influencia de la pentoxifilina en el proceso cicatricial

    OpenAIRE

    Parra Membrives, Pablo

    2006-01-01

    El principal problema causante de morbi-mortalidad al que se enfrenta el cirujano digestivo viene dado por las complicaciones relacionadas con las dehiscencias anastomóticas, y de modo particular las que afectan al colon y recto. Existen numerosos factores citados como causantes de la aparición de una fuga anastomótica. La mayoría de las causas señaladas, sin embargo, conducen finalmente a un cierto grado de isquemia o hipoperfusión, y, en el peor de los casos, a un evento de lesión por isque...

  1. {sup 18}F-F.D.G. PET imaging of infection and inflammation: intestinal, prosthesis replacements, fibrosis, sarcoidosis, tuberculosis..; La TEP au {sup 18}F-FDG dans la pathologie inflammatoire et infectieuse: intestinale, prothetique, fibrose, sarcoidose, tuberculose..

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, A.; Cortes, M.; Caresia, A.P.; Juan, R. de; Vidaller, A.; Mana, J.; Martinez-Yelamos, S.; Gamez, C. [Hospital Universitari de Bellvitge, Service TEP-Centre IDI, Services de Medecine Interne, Barcelone (Spain)

    2008-10-15

    Nuclear medicine plays an important role in the evaluation of infection and inflammation. A variety of diagnostic methods are available for imaging this inflammation and infection, most notably computed tomography, {sup 68}Ga scintigraphy or radionuclide labeled leucocytes. Fluorine 18 fluorodeoxyglucose ({sup 18}F-F.D.G.) is a readily available radiotracer that offers rapid, exquisitely sensitive high-resolution images by positron emission tomography (PET). Inflammation can be acute or chronic, the former showing predominantly neutrophilic granulocyte infiltrates, whereas in the latter, macrophages predominate. F.D.G. uptake in infection is based on the fact that mononuclear cells and granulocytes use large quantities of glucose by way of the hexose monophosphate shunts. {sup 18}F-F.D.G. PET accurately helps diagnose spinal osteomyelitis, diabetic foot and in inflammatory conditions such as sarcoidosis and tuberculosis.(it appears to be useful for defining the extent of disease and monitoring response to treatment). {sup 18}F-F.D.G. PET can also help localize the source of fever of undetermined origin, thereby guiding additional testing. {sup 18}F-F.D.G. PET may be of limited usefulness in postoperative patients and in patients with a failed joint prosthesis or bowel inflammatory disease. In this review, we will focus on the role of {sup 18}F-F.D.G. PET in the management of patients with inflammation or suspected or confirmed infection.

  2. Caractérisation structurale et biologique de nouveaux agents antibactériens naturels actifs dans les infections intestinales : des peptides de la chromogranine A et des principes actifs de Chromolaena odorata

    OpenAIRE

    Atindehou, Ménonvè

    2012-01-01

    The first bacterial strains resistant to antibiotics appeared 70 years ago and have proliferated in recent years causing a serious public health problem. Such bacteria are responsible of several types of infections including intestinal infections with chronic inflammatory bowel diseases and cancers. This work consisted of proposing new therapeutic tools in the treatment of intestinal pathologies. In this context, we have studied antimicrobial peptides derived from chromogranin A and plant ext...

  3. Synthese und biologische Evaluierung von fluorierten und carbaanalogen Glycopeptiden für die Entwicklung von tumorselektiven Vakzinen

    OpenAIRE

    Wagner, Sarah

    2012-01-01

    Tumorassoziierte Kohlenhydrat-Antigene werden von einer Vielzahl epithelialer Tumoren in erhöhtem Maße exprimiert und können sowohl als selektive Tumormarker, als auch als Zielstrukturen zur Entwicklung von synthetischen Krebsvakzinen dienen. Mucine, allen voran MUC1, sind hochgradig O-glycosylierte Zelloberflächenproteine, die im Fall maligner Zellen in deutlich überexprimierter Form mit charakteristisch veränderten Glycosylierungsmustern auftreten und somit vom Immunsystem erkannt werden kö...

  4. Funktionelle Untersuchungen zum Einfluss von FAP-Inhibitoren auf die Tumorzellmigration und Invasion

    OpenAIRE

    Kirchner, Paul

    2005-01-01

    Das Fibroblasten-Aktivierungs-Protein (FAP) ist eine Oberflaechenprotease mit kollagenolytischer Aktivität in vitro, die in vivo spezifisch von Fibroblasten in der Umgebung maligner epithelialer Tumoren in der Phase der Invasion und Disseminierung aufreguliert wird. Da Matrixproteasen durch proteolytischen Umbau extrazellulärer Matrix zu Invasion und Metastasierung von Tumoren beitragen, stellen sie interessante Zielstrukturen für die Pharmakotherapie von Tumorerkrankungen dar....

  5. Effetto pro-ossidante e pro-infiammatorio degli ossisteroli in cellule intestinali: attività modulatoria della frazione fenolica del vino

    OpenAIRE

    Cabboi, Barbara, Paola Melis, M.

    2014-01-01

    Because the intestine sits at the interface between the organism and its luminal environment, it represents a critical defense barrier against luminal toxic agents. Thus, in addition to being exposed to luminal nutrients, the intestinal mucosa is constantly challenged by diet-derived oxidants, mutagens, and carcinogens as well as by endogenously generated reactive oxygen species. Among the oxidizing agents cholesterol oxidation products, oxysterols, are particularly relevant; besides being ge...

  6. Simulation numérique des phénomènes thermiques et magnétohydrodynamiques dans une cellule de Hall-Héroult

    OpenAIRE

    Safa, Yasser

    2005-01-01

    This work is concerned with a numerical simulation of the thermal behaviour of an electrolysis cell for the production of the aluminium. Aluminium is produced by an electrolytic reduction of alumina dissolved in a bath of molten cryolite. In this reduction process, called Hall-Héroult process, the metal is produced at about 965 °C. A frozen bath layer, called ledge, arises in the boundary region and protects the side walls of the cell from corrosive electrolyte. This ledge may change the magn...

  7. Contribution du foie et des cellules dendritiques plasmacytoïdes dans la réponse humorale à Immunoglobines A

    OpenAIRE

    Moro-Sibilot, Ludovic

    2015-01-01

    IgA humoral response is one of the main mechanisms by which immune homeostasis is maintained in the intestine. The IgA response is initiated in gut-associated lymphoid tissues, where recognition of intestinal antigens drives naïve B cell activation, IgA class-switch recombination and plasma cell differentiation. My thesis work addressed the contribution of the liver and plasmacytoid dendritic cells (pDCs) in intestinal IgA response. By using two complementary mouse models allowing for selecti...

  8. Mesenchymal stem cells favour healing of the cutaneous radiation syndrome; Les cellules souches mesenchymateuses favorisent la cicatrisation des lesions cutanees radio induites

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Mathieu, N.; Semont, A.; Monti, P.; Dudoignon, N.; Sache, A.; Boutarfa, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [IRSN, Dir. de radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France)

    2006-10-15

    It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immuno-deficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a {sup 60} Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immuno-histology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy. (authors)

  9. Targeted therapies and radiation therapy in non-small cell lung cancer; Therapies ciblees et radiotherapie dans les cancers bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, S.; Quero, L.; Wong Hee Kam, S.; Maylin, C.; Hennequin, C. [Service de cancerologie radiotherapie, hopital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris (France); Deutsch, E. [UMR 1030 ' radiosensibilite des tumeurs et tissus sains ' , Inserm, 114, rue edouard-Vaillant, 94805 Villejuif (France); Departement de radiotherapie, institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif (France)

    2011-10-15

    Lung cancer is the leading cause of cancer-related death. Between 80-85% of lung cancers are non-small cell lung carcinomas. One third of the patients are diagnosed with locally advanced stage. In this condition, concomitant radio-chemotherapy is the standard treatment for patients with good performance status. Despite important improvements in the last years, non-small cell lung carcinoma prognosis remains poor, with high rates of both local recurrences and metastases. The heterogeneity of molecular characteristics of non-small cell lung carcinoma cells and a better knowledge of potential targets offer promising developments for new pharmacologic agents. Hereafter we will review the currently most studied pathways and the most promising ones for the treatment of locally advanced unresectable non-small cell lung carcinoma. Two of the most attractive pathways where new agents have been developed and assessed in combination with thoracic radiotherapy or radio-chemotherapy are the EGFR pathway (either with the use of monoclonal antibodies or tyrosine kinase inhibitors) and the angiogenesis inhibition. The development of targeted agents could lead to individualized therapeutic combinations taking into account the intrinsic characteristics of tumor cells. Pharmacological modulation of tumour cells radiosensitivity by targeted therapies is only starting, but yet offers promising perspectives. (authors)

  10. Primer informe de celulitis cutánea por Erysipelothrix rhusiopathiae en dos trabajadores rurales First report of cutaneous cellulitis caused by Erysipelothrix rhusiopathiae in two rural workers

    OpenAIRE

    Mónica Delfina Sparo; María Marta De Luca; Celia María Schell; Juan Angel Basualdo Farjat

    2011-01-01

    Se informan dos casos de celulitis cutánea en trabajadores de un mismo criadero de aves a corral del área rural de la ciudad de Tandil, Argentina. En ambos pacientes fue identificado E. rhusiopathiae a partir de cultivos de muestras obtenidas por biopsia. La investigación del reservorio evidenció que en todas las muestras de las excretas de aves y en dos muestras de los residuos del alimento, se aisló E. rhusiopathiae con idéntico perfil bioquímico y de resistencia antimicrobiana al de las ce...

  11. Tumeur à cellules géantes du fémur proximal traitée par arthroplastie totale de hanche

    Science.gov (United States)

    Mhammdi, Younes; Kharmaz, Mohamed

    2016-01-01

    The authors report the case of a giant cell tumor grade 1 of the proximal femur, diagnosed in a young patient of 18 years. The diagnosis was suspected on a standard x-ray complemented by MRI, it was confirmed on histological examination after biopsy. The tumor was a metaphyseal-epiphyseal location above the level of the femoral cut on preoperative planning. The management had combined two surgical techniques, with a marginal resection of the femoral head and neck, and femoral curettage-filling of the metaphyseal region with implantation of a total cemented hip prosthesis. After 2 years of follow up, the result is very satisfactory with good functional recovery and no signs of recurrence. PMID:27279937

  12. Etude de nouvelles cibles moleculaires de cancer bronchopulmonaire non a petites cellules pharmacomodulées par des substances originales naturelles et synthetiques

    OpenAIRE

    Moreau, Dimitri

    2006-01-01

    Maladie encore rare au début du 20ème siècle, le cancer du poumon est à l'origine de plus de 6 % des décès en France actuellement. Il occupe le premier rang des décès par cancer alors que la France est considérée comme un pays à risque moyen parmi les pays occidentaux. La découverte de nouveaux traitements anticancéreux toujours plus efficaces et spécifiques, est donc aujourd'hui primordiale. La validation de la capacité d'une molécule à pouvoir inhiber la prolifération cancéreuse, passe ...

  13. In vitro studies of interactions between uranium and kidney cells; Etudes in vitro des interactions entre l'uranium et les cellules renales (doctorat: toxicologie cellulaire)

    Energy Technology Data Exchange (ETDEWEB)

    Mirto, H

    1999-07-01

    A best knowledge of uranium compounds toxic effects is essential due to of the risk of occupational internal contamination. The aim of this work is to describe, by the original use of cell culture models for uranium, the mechanisms of interactions between uranium and its renal targets. Two renal models are studied: in the one hand the tubular proximal one (LLC-PK{sub 1} cells) and on the other hand, the glomerular model (isolated glomeruli and primary culture of mesangial cells). The chemical conditions permitting the observation of uranium (VI) cytotoxicity on LLC-PK{sub 1} cells were determined. They show that merely solutions prepared with bicarbonate and citrate ligands concentrations 10 fold higher than the metal are soluble in the culture medium Cytotoxicity experiments reveal that only uranium-bicarbonate complexes induce a dose-related cytotoxicity response. Electron microscopy studies conducted with uranium-bicarbonate solutions show that uranium precipitate in the intracellular compartment. In contrast, no toxicity and no intracellular intake are noticed with uranium-citrate complexes. Theoretical speciation diagrams let us to determine that the UO{sub 2}(CO{sub 3}){sub 2}{sup 2-} complex is responsible for the uranium toxic effects. These results allow us to propose a new model whereby uranium intake by tubular proximal cells would take place in two stages: firstly by attachment of UO{sub 2}(CO{sub 3}){sub 2}{sup 2-} complexes to the proteins of cell membrane and secondly by an endocytosis process. The monitoring of the variations of morphometric parameters of glomerular structures permit to put in evidence the uranium-induced vaso-reactivity for sub-lethal concentrations. The protective effect of a calcium channels blocker demonstrate the main role played by calcium ions in the uranium-induced glomerular contraction. These studies show that uranium induces glomerular effects for sub-lethal concentrations. (author)

  14. Realisation and characterization of organic photovoltaic cells obtained by physical vapor deposition; Realisation et caracterisation de cellules photovoltaiques organiques obtenues par depot physique

    Energy Technology Data Exchange (ETDEWEB)

    Brousse, B.

    2004-12-01

    This work deals with the synthesis and the characterization of low cost organic solar cells, contributing to the development of renewable energies, and able to feed devices as portable telephone...In particular, we have contributed to the development of an experimentation bench for the obtention of different structures (bilayers, interpenetrated and multilayers) of solar cells from different donor-acceptor couples of small molecules. After having presented a retrospective of the physical phenomena and of the mechanisms involved, as well as those of the photovoltaic principle in the organic materials, we describe the technological steps allowing to carry out the solar cells. The materials (organic and metallic) are deposited on thin films (of 30 to 100 nm) spin-coating (PEDOT-PSS) or by vacuum evaporation (small molecules and metallization of the cathode) on a glass substrate covered by a conducting and a semi-transparent ITO layer constituting the anode. The structures carried out have been characterized in air in obscurity and under illumination by curves I(V), by capacitive measurements and IPCE spectra (photocurrent spectra). Different donor-acceptor couples (phthalocyanine/C60, oligomer of thiophene/C60 and phthalocyanine/perylene derivative) have been tested by various configurations: p-n heterojunctions distributed or not in the volume. The obtained results are better for the bilayers structures on account of the granularity of the C60. This characteristics have allowed us to carry out an efficient multilayer structure (CuPc/C60). In order to resolve the problem of the deposit of the C60, we have tested another acceptor molecule: a derived compound of the perylene (PPTC). Complementary studies have been carried out by the ionic implantation of the active layers, allowing both a densification and a doping of these ones; the encapsulation of the compounds by polyimide VDP (gaseous phase polymerization) have been evaluated. With this technique, we have developed too an alternative auto-protected structure. (O.M.)

  15. Une métastase intra-thyroïdienne révélant un cancer bronchique non à petites cellules

    Science.gov (United States)

    Boukir, Anwar; El Kabous, Mustapha; Azghari, Ilham; Boutayeb, Saber; El Ghissassi, Ibrahim; Mrabti, Hind; Errrihani, Hassan

    2015-01-01

    Les métastases thyroïdiennes sont très peu fréquentes. Elles peuvent de façon exceptionnelle révéler le cancer primitif. Nous rapportons le cas d'une patiente qui a présenté une dysphonie secondaire à un gros nodule thyroïdien lobaire droit. L'examen anatomopathologique de la pièce de l'hémi thyroïdectomie a révélé la présence d'un adénocarcinome d'origine pulmonaire. Le bilan d'extension a confirmé la présence d'une masse au niveau du Fowler droit ainsi qu'une métastase du trochanter fémoral droit et une récidive au niveau de la loge thyroïdienne. Une chimiothérapie à base de Paclitaxel, Carboplatine et Bevacizumab a été débuté. L’évaluation après 4 cures est en faveur d'une stabilité radiologique avec amélioration des symptômes. PMID:26918084

  16. Effets thérapeutiques des cellules T regulatrices induitent par TGF-β sur l’autoimmunité et l’inflammation préétablies

    OpenAIRE

    Zheng, Song Guo

    2011-01-01

    Recent studies revealed that nTregs has less therapeutic effects on established autoimmune diseases. Current study asks if iTregs induced ex-vivo with TGF- can treat the established autoimmune diseases. In allergic asthma we observed that adoptive transfer of iTreg significantly suppressed airway and peri-vascular inflammation, reduced airway résistance, eosinophil recruitment, mucus hyper-production, airway remodeling and IgE levels. This therapeutic effect was associated with increase of Tr...

  17. Modélisation et conception d'un système de mesure de comportement électrique de cellules vivantes: Application aux Epitheliums intestinaux.

    OpenAIRE

    Mathieu, Julien

    2008-01-01

    With electrical parameters such as the short circuit current, the transepithelial voltage and the conductance it is possible to study electrogenic transport across biological barriers. These measurements can be useful for the study of a molecule on the basis of its crossing behavior and its action on the epithelium properties, its dose effect relationship and its comparison with known molecules. The purpose of this work was to achieve an automated device which can measure these three electric...

  18. Studio dell'attività antiproliferativa e dello stato di stress ossidativo nelle cellule tumorali di prostata (PC3) dopo trattamento con alfa-tocoferolo e naringenina

    OpenAIRE

    Torricelli, Piera

    2010-01-01

    I flavonoidi sono un gruppo di composti polifenolici che si trovano nella piante e che giocano un ruolo importante in molti processi fisiologici. Tali composti hanno infatti un notevole spettro di attività biologiche tra cui proprietà antiallergiche, antinfiammatorie, antiossidanti e anticarcinogeniche. Numerosi studi sia in vivo che in vitro dimostrano un ruolo importante dei flavonoidi nella prevenzione e nella cura del cancro. Tali proprietà antitumorali e pro-apoptotiche sono generalmente...

  19. Study on the improvement of the reliability of solar cells on polymer substrates; Etude et amelioration de la fiabilite des cellules solaires sur substrats polymeres

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D.; Ziegler, Y.; Closset, A.

    2004-07-01

    This final report for the Swiss Federal Office of Energy (SFOE) presents the results of work done on the improvement of the long-term reliability of flexible solar cells deposited on polyimide substrates. Several possibilities were explored simultaneously, including vacuum-de-gassing of the polyimide film, the prevention of water absorption by using diffusion barriers and the reduction of mechanical stress in the thin silicon layers. Work completed is described, including the adaptation of the deposition system, the structuring of metal coatings and improvements to existing equipment to reduce defects caused by dust. The continual effort being made to stabilise the production process and make it economically viable is noted.

  20. Simulation numérique des phénomènes thermiques et magnétohydrodynamiques dans une cellule de Hall-Héroult

    OpenAIRE

    Safa, Yasser; Rappaz, Jacques

    2007-01-01

    This work is concerned with a numerical simulation of the thermal behaviour of an electrolysis cell for the production of the aluminium. Aluminium is produced by an electrolytic reduction of alumina dissolved in a bath of molten cryolite. In this reduction process, called Hall-Héroult process, the metal is produced at about 965 °C. A frozen bath layer, called ledge, arises in the boundary region and protects the side walls of the cell from corrosive electrolyte. This ledge may change the magn...

  1. Nouveaux matériaux d’anode et cellules architecturées pour électrolyseur à haute température

    OpenAIRE

    Ogier, Tiphaine

    2012-01-01

    In order to improve the electrochemical performances of cells for high temperature steam electrolysis (HTSE), innovative oxygen electrode materials have been studied. The compounds Ln2NiO4+δ (Ln = La, Pr or Nd), Pr4Ni3O10±δ and La0.6Sr0.4Fe0.8Co0.2O3-δ have been selected for their mixed electronic and ionic conductivity. First, their physical and chemical properties have been investigated. Then, the electrodes were shaped on symmetrical half cells,adding a thin ceria-based interlayer between ...

  2. Apport de la pression sur les performances d'une cellule d'électrolyse de la vapeur d'eau à haute température

    OpenAIRE

    Cacciuttolo, Quentin

    2014-01-01

    In order to improve the industrial attractiveness of high temperature steam electrolysis (HTSE), the increase in the operating pressure is one of the most promising solutions. In this context, this study is dedicated to the analysis of the pressure influence on the electrochemical reactions occurring in HTSE. A Model and experimental results dealing with the effect of pressure increase have been carried out. Concerning the cathodic side model, the limiting current density due to the lack of s...

  3. Treatment of radioinduced skin burns by adult stem cells;Traitement des brulures cutanees radio-induites par cellules souches adultes

    Energy Technology Data Exchange (ETDEWEB)

    Lataillade, J.J.; Prat, M. [Hopital Militaire Percy, Centre de Transfusion Sanguine des Armees, Dept. Recherches et Therapies Cellulaires, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Bey, E. [Hopital Militaire Percy, Service de Chirurgie Plastique, 92 - Clamart (France)

    2009-12-15

    In the area of skin injuries caused by ionizing radiations; the recent opportunity give us the the possibility to manage victims of radiation accidents with skin acute symptoms of irradiation. The approach of cell therapy developed for these patients could be in a second time, used for other types of injuries as thermal burns and the injuries linked to overexposure in radiotherapy. In spite of the diversity of approaches of allogeneic and autologous transplantation, the prognosis of deep and extended radioinduced burns is not completely satisfying because of inflammatory recurrences, origin of graft failures. The stem cells have been used in association. The stem cells were got from sampling of autologous bone marrow after an expansion in vitro from 15 to 17 days. The cultures were realised in medium with 8% of platelet lysate (clinical grade). The cells have been given by injection in complement of epidermis auto graft. A spectacular effect was noticed the day after the injection, but disappearing in some days encouraging to realize supplementary injections. An effect of the quickness and the quality of the graft success is appeared significant too. no necrosis recurrence for the patients after four years for the first one of them. We think that the stem cells participate to the local control of inflammation. (N.C.)

  4. Diagnosi prenatale non invasiva di malattie monogeniche attraverso la ricerca e l'isolamento di cellule e DNA fetale nel sangue materno

    OpenAIRE

    Contini, Antonella

    2012-01-01

    Prenatal genetic diagnosis of monogenic diseases and chromosomal abnormalities is usually performed collecting fetal samples through villocentesis or amniocentesis. These invasive procedures are associated with 0.5-1% risk for the fetus. Due to it, in recent years, much effort has been made to develop non invasive prenatal diagnosis (NIPD). Two potential non invasive approaches involve the analysis of fetal cells and cell-free fetal DNA (cffDNA) found in the maternal circulation. The prese...

  5. Human stem cells for the treatment of motorneuron diseases: regenerative potential, translatability and development of new biotechnologies. Cellule staminali umane per la cura delle malattie degenerative del motoneurone

    OpenAIRE

    Canzi,

    2010-01-01

    Stem cell therapy is considered one of the most promising approaches against different neurodegenerative disorders, including Amyotorophic Lateral Sclerosis (ALS). The evidence that the systemic injection of human cord blood mononuclear cells (HuCB-MNC) was able to reduce the clinical outcomes and increase the lifespan in a murine model of fALS1, the SOD1G93A mouse, even if localized far from affected motor neurons, opens the way for new possible candidates and alternative ways of administrat...

  6. Absceso y flegmón periamigdalino ¿Lo estamos haciendo bien? Abscess and cellulitis peritonsillar ¿Are we doing it right?

    OpenAIRE

    César Gómez V; Edda Pruzzo Ch; Eduardo Reyes S; María de los Angeles Contreras R; José Miguel Contreras R; Viviana Vergara T

    2006-01-01

    El flegmón (celulitis) y el absceso periamigdalino son infecciones difusas o una colección ubicada entre la cápsula fibrosa de la amígdala palatina, las fibras horizontales del músculo constrictor superior de la faringe y las verticales del músculo palatofaríngeo. Constituye la infección de tejidos y espacios profundos del cuello más frecuente. Material y método: Revisión retrospectiva de las fichas de pacientes adultos y niños hospitalizados con diagnóstico de absceso o flegmón periamigdalin...

  7. Nuove strategie manipolative ex vivo per il purging delle unità di cellule staminali ematopoietiche periferiche destinate al trapianto autologo di midollo

    OpenAIRE

    Veronesi, Arianna

    2015-01-01

    NEW MANIPULATIVE STRATEGIES EX VIVO FOR PURGING OF PHERIPHERAL HAEMATOPOIETICS STEM CELLS UNITS AIMED FOR AUTOLOGOUS BONE MARROW TRANSPLANTATION This thesis aims to evaluate the possibility of using the Gemtuzumab ozogamicin in ex vivo purging of autologous pheripheral blood mononuclear cells, in order to eliminate possible contaminants leukaemia cells. The use of this drug is subject to verification that the depletion of malignant cells does not cause cytotoxic effects on normal stem cel...

  8. Dealing with Cuts (For Parents)

    Science.gov (United States)

    ... MORE ON THIS TOPIC Cellulitis First Aid: Cuts Staph Infections Bites and Scratches First Aid: Falls First Aid: ... What's a Scab? Cellulitis Cuts, Scratches, and Scrapes Staph Infections Dealing With Cuts and Wounds Babysitting: Dealing With ...

  9. Inflammation of the Orbit

    Science.gov (United States)

    ... Diagnosis Treatment Medical Dictionary Additional Content Medical News Inflammation of the Orbit (Inflammatory Orbital Pseudotumor) By James ... Introduction to Eye Socket Disorders Cavernous Sinus Thrombosis Inflammation of the Orbit Orbital Cellulitis Preseptal Cellulitis Tumors ...

  10. Insights into the molecular bases of the interaction of Bifidobacterium bifidum PRL2010 with the human host and with other human gut commensals.

    OpenAIRE

    Serafini, Fausta

    2014-01-01

    I bifidobatteri sono tra i microrganismi maggiormente presenti nel tratto gastro-intestinale (GIT) dei mammiferi. Sono batteri anaerobi obbligati appartenenti al phylum degli Actinobacteria, Gram-positivi ad alto contenuto di G+C nel genoma. Sono state identificate 47 taxa di bifidobatteri, 11 delle quali isolate dal GIT umano. Sono i primi colonizzatori del tratto gastro-intestinale dei neonati e predominano in quelli allattati al seno, invece dopo lo svezzamento sono in quantità minore risp...

  11. Il trattamento della SIBO (Small Intestinal Bacterial Overgrowth) nella sindrome dell'intestino irritabile

    OpenAIRE

    Carloni, Cecilia

    2009-01-01

    Recenti evidenze indicano che fattori irritanti endoluminali, quali la flora microbica intestinale e fattori infettivi-infiammatori, partecipino alla genesi dei disturbi motori e sensoriali intestinali presenti nella sindrome dell’intestino irritabile (IBS). Da tali studi sembra emergere in particolare un’importante correlazione tra IBS ed una forma particolare di dismicrobismo intestinale ovvero l’overgrowth batterico dell’intestino tenue (SIBO), caratterizzata dalla presenza nell’intesti...

  12. In vitro- und ex vivo-Studien zum humanen intestinalen Metabolismus und zu Lipoxygenase-hemmenden Eigenschaften ausgewählter sekundärer Pflanzeninhaltsstoffe

    OpenAIRE

    Knaup, Bastian

    2008-01-01

    Um eine Verbindung zwischen den bereits bekannten in vitro-Effekten und der bislang weitgehend ungeklärten in vivo-Situation zu knüpfen, wurden der intestinale Metabo-lismus sowie die Lipoxygenase-hemmenden Eigenschaften von ausgewählten sekun-dären Pflanzeninhaltsstoffen mit verschiedenen Modellsystemen untersucht. Folgende kamen zur Anwendung: intestinaler Metabolismus Lipoxygenase-hemmende Eigenschaften - menschlicher Speichel - Soja Lipoxygenase-1 - künstlicher Magensaft - 5-Lipoxygenase ...

  13. Pruebas de sensibilidad frente a agentes antimicrobianos en cepas de brachyspira pilosicoli aisladas a partir de ponedoras comerciales en colombia

    OpenAIRE

    Alvarez Mira, Diana Marcela; Pulido Landinez, Martha; Figueroa Ramìrez, Judith

    2010-01-01

    Las espiroquetas intestinales del género Brachyspira ocasionan enfermedades importantes en porcinos y aves. Se ha evidenciado un problema de incremento en la presentación de cepas resistentes a los antimicrobianos utilizados normalmente para tratar las espiroquetosis intestinales en porcinos, y esto podría ser aplicable a los aislamientos de aves. Hay muy pocos reportes de sensibilidad antimicrobiana in vitro de cepas de Brachyspira spp. Aisladas en aves. En este estudio se evaluó la sensibil...

  14. Rôle des acides biliaires et de leur récepteur TGR5 dans la régulation de la somatostatine pancréatique et intestinale : conséquences fonctionnelles sur les îlots pancréatiques humains

    OpenAIRE

    QUENIAT, Gurvan

    2015-01-01

    Bile acids (BAs) have evolved over the years from being considered as simple lipid solubilizers to metabolically active molecules. In addition to their function in dietary lipid absorption, they have also been shown to activate farnesoid X receptor (FXR) and TGR5 receptors to initiate signaling pathways and regulate metabolic gene transcription. TGR5 (encoded by the GPBAR1 gene), also known as G-protein-membrane-type receptor for bile acids (M-BAR) or G-protein-coupled bile acid receptor 1 (G...

  15. Recherche d’alcaloïdes dans les plantes consommées par Pan paniscus et celles utilisées pour le traitement des maladies gastro-intestinales par Homo sapiens à LuiKotale (Parc National de la Salonga en RD Congo)

    OpenAIRE

    Kitengie Matshimba, Gaby; Fruth, Barbara; Bondjengo Ikombe, Nono; Musibono, Dieudonné; Lubini, Constantin; Hohmann, Gottfried

    2014-01-01

    Les plantes comme d’autres êtres vivants ont développé un certain nombre de mécanismes pour se protéger contre les prédateurs et les infections. Les métabolites secondaires sont considérés comme des moyens de défense des plantes contre les herbivores. Servant d’antidotes, dans certains cas, ils peuvent être ingérés pour l'automédication chez les animaux. Depuis 2002, nous avons étudié l'utilisation des plantes par les bonobos (Pan paniscus, Pp) et les humains (Homo sapiens, Hs) à LuiKotale, e...

  16. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  17. Implicación del estrés oxidativo, alimentación, estilo de vida y variantes polimórficas del gen de apolipoproteína D en pacientes con pólipos intestinales y con adenocarcinoma esporádico de colon

    OpenAIRE

    Crespo Sanjuán, Jesús

    2012-01-01

    El estrés oxidativo (EO) constituye un mecanismo fundamental en la génesis de cáncer colorectal (CRC) dando lugar a las mutaciones que convierten las células en cancerosas. Comprobamos cómo existe un incremento del EO en sangre y en tejido de pacientes con pólipos y con CRC conforme avanza la enfermedad. Se trata del primer estudio que analiza en plasma de estos pacientes los valores de Mieloperoxidasa, encontrándose incrementados a medida que avanza el estadío. Los pacientes que consu...

  18. The contribution of radiation-induced injury to the gastrointestinal tract in the development of multi-organ dysfunction syndrome or failure; Contribution des atteintes gastro-intestinales dans le developpement du syndrome de defaillance multi-viscerale radio-induit

    Energy Technology Data Exchange (ETDEWEB)

    Monti, P.; Van Der Meeren, A.; Griffiths, N.M. [Institut de Radioprotection et de Surete Nucleaire (IRSN/DRPH/SRBE), Lab. de Therapie Cellulaire et Radioprotection Accidentelle, 92 - Fontenay-aux-Roses (France); Van Der Meeren, A.; Griffiths, N.M. [CEA Bruyeres-le-Chatel, DSV/DRR, Lab. de Radiotoxicologie, 91 (France)

    2006-01-15

    Severe damage to the gastrointestinal tract (GIT), such as Toss of mucosa and hemorrhaging following accidental overexposure to ionising radiation, appear to be a determinant feature in patient mortality. Injury to the GIT may be direct since this tissue is particularly radiation sensitive and indirect as a result of radiation burns and bone marrow aplasia. Similar to other severe trauma situations such as thermal burns or hemorrhagic shock, radiation exposure results in reduced intestinal barrier integrity which initiates and/or perpetuates inflammatory-anti-inflammatory mediator release. This may result in damage to distant organs. In this context the injured gut may be considered as a 'key player' or 'motor' in the development of Multiple Organ Dysfunction Syndrome or Failure (MODS/MOF). Of note is that radiation exposure elicits similar GIT injury of both mucosal and vascular elements as compared with other severe physical insults. Common factors are the intestinal inflammatory response and loss of barrier function. This radiation-induced response must be taken into account in intestinal responses after irradiation exposure in order to have a better knowledge of its implication in the mixed-pathology of the acute radiation syndrome. (author)

  19. Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAIS use as assessed by capsule endoscopy Valoración mediante cápsulas endoscópicas de las lesiones intestinales mucosas causadas por antiinflamatorios no esteroideos (AINE

    Directory of Open Access Journals (Sweden)

    A. Caunedo-Álvarez

    2010-02-01

    Full Text Available Objective: to evaluate the type, frequency, and severity of macroscopic small bowel mucosal injury after chronic NSAID intake as assessed by capsule endoscopy (CE, as well as to correlate the severity of gastroduodenal and intestinal damage in these patients. Material and methods:a prospective, endoscopist-blind, controlled trial. Sixteen patients (14F/2M; age: 57.06 ± 10.16 yrs with osteoarthritis (OA on chronic therapy with NSAIDs underwent CE and upper gastrointestinal endoscopy (UGE. Seventeen patients with OA (9F/2M; age: 57.47 ± 9.82 yrs who did not take NSAIDs were included as a control group. A scale ranging from 0 to 2 (0 = no lesions, 1-minor = red spots or petechiae, denuded areas and/or 1-5 mucosal breaks; 2-major = > 5 mucosal breaks and/or strictures, or hemorrhage was designed to assess the severity of small bowel mucosal injuries. Results: CE found intestinal lesions in 75% (12/16 of patients in the study group and in 11.76% (2/17 of controls (p < 0.01. Seven out of 16 NSAID consumers (43.75% and none in the control group (0% had a major small bowel mucosal injury (p < 0.01. The percentages of patients with grade 1 and 2 gastroduodenopathy in the study group, as assessed by UGE, were 37.14 and 23.81%, respectively. There was no significant difference in the rate of major enteropathy between patients with none or minor gastroduodenal injury, and those with major gastroduodenopathy (43.75 vs. 40%; p = N.S.. Conclusions: chronic NSAID intake is associated with a high rate of small bowel mucosal injuries. Our data have failed to demonstrate a relationship between the severity of gastroduodenal and intestinal injury.

  20. Characterisation in vivo of ways of induced deaths by p53, in the male germinal cells; Caracterisation in vivo des voies de mort induites par la p53, dans les cellules germinales males

    Energy Technology Data Exchange (ETDEWEB)

    Coureuil, M

    2006-10-15

    The male germinal cells constitute a heterogeneous cell population including pre-meiotic proliferating cells (spermatogonia) and meiotic cells and post meiotic cells in differentiation (spermatocytes and spermatids). We study the involvement in vivo of the p53 protein in the death of these cells with the help of two models, (1) a transgenic model of infertility, MTp53, in which the p53 is over expressed in the differentiated cells and induced their death, (2) the response of these cells to gamma irradiation, where only the spermatogonia die by apoptosis dependent of p53. We showed that the caspases (cysteine-aspartic proteases) are involved in the terminal differentiation of normal germinal cells. But in the MTp53 model, the p53 induces the death of differentiated cells via the activation of calpains and not of caspases. We studied the response of spermatogonia, to gamma irradiation by a transcriptomic approach, by DNA chips and semi-quantitative RT-PCR. we showed that the puma and dr5 genes are induced by the p53 after irradiation. more, the study of mice invalidated for trail ( the dr5 ligand) or for puma, allowed to demonstrate that the two effectors are essential to the activation of intrinsic and extrinsic ways of apoptosis. (N.C.)

  1. Modèle de tenségrité viscoélastique pour l'étude de la réponse dynamique des cellules adhérentes

    OpenAIRE

    Cañadas, Patrick

    2003-01-01

    Un modèle de tenségrité viscoélastique (MTV) composé de 6 barres quasi-rigides et de 24 câbles viscoélastiques est développé et son comportement mécanique est étudié dans les domaines temporel et fréquentiel pour comprendre le rôle joué par la déformation structurale du cytosquelette dans la réponse cellulaire en petites et grandes déformations. Des simulations numériques de tests de fluage ainsi que d'oscillations imposées sont effectuées, permettant d'établir des lois de dépendance entre d'...

  2. Nursing of a case of severe chickenpox combine multiple cellulitis%1例重症水痘合并多处蜂窝组织炎的护理

    Institute of Scientific and Technical Information of China (English)

    夏文君

    2013-01-01

    对1例重症水痘患儿合并多处蜂窝织炎的病例进行回顾性分析.水痘合并肺炎、脑炎、肝损伤较多见,并发多处蜂窝织炎不多见,此病例经过护理人员采取保护性隔离、皮肤护理、病情观察、伤口护理、心理护理等措施后,患儿治愈出院.

  3. Isolement et caractérisation des saponosides de trois plantes de la famille des araliaceae et dracaenaceae et évaluation de leurs activités cytotoxiques sur cellules tumorales

    OpenAIRE

    Kougan Nkwokap, Guy Beddos

    2010-01-01

    L'intérêt des substances d'origine naturelle, potentiellement anti-tumorales nous a amené à nous intéresser aux saponines triterpéniques et stéroïdiques de plantes issues de la biodiversité africaine de la famille des Araliaceae et des Dracaenaceae. En effet, des études antérieures menées sur quelques plantes de ces deux familles ont conduit à l'obtention de molécules complexes et originales possédant d'excellentes propriétés cytotoxiques, immuno-modulatrices, anti-inflammatoires. Au vu de ce...

  4. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells; Approches therapeutiques du syndrome hematopoietique apres irradiation globale accidentelle grave. Interet de l`expansion ex vivo des cellules hematopoietiques

    Energy Technology Data Exchange (ETDEWEB)

    Thierry, D.

    1994-12-31

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too.

  5. Cellular therapy by mesenchymal stem cells in the gamma radiation-induced multi organ dysfunction syndrome; Therapie cellulaire par cellules souches mesenchymateuses d'une atteinte multi-organes induite par une irradiation gamma: un modele experimental

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Semont, A.; Frick, J.; Sache, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [Institut de Radioprotection et de Surete Nucleaire (IRSN), Direction de la Radioprotection de l' Homme, 92 6 Fontenay-aux-Roses (France); Gorin, N.C. [Universite Paris -6 Pierre et Marie Curie, Faculte de Medecine Saint-Antoine, Lab. de Therapie Cellulaire et Radioprotection Accidentelle, EA 1638, 75 - Paris (France); Hopital Saint-Antoine, Service d' Hematologie et de Therapie Cellulaire, 75 - Paris (France)

    2007-07-15

    Mesenchymal stem cells (M.S.C.) have been shown to migrate to various tissues. There is little information on the fate and potential therapeutic efficacy of the re infusion of M.S.C. following total body irradiation (T.B.I.). We addressed this question using human M.S.C. (h.M.S.C.) infused to non obese diabetic/severe combined immuno-deficient (N.O.D./S.C.I.D.) mice submitted to T.B.I.. Further, we tested the impact of additional local irradiation (A.L.I.) superimposed to T.B.I., as a model of accidental irradiation. N.O.D./S.C.I.D. mice were transplanted with h.M.S.C.. Group 1 was not irradiated before receiving h.M.S.C. infusion. Group 2 received only T.B.I. at a dose of 3.5 Gy, group 3 received local irradiation to the abdomen at a dose of 4.5 Gy in addition to T.B.I., and group 4 received local irradiation to the leg at 26.5 Gy in addition to T.B.I.. Fifteen days after gamma irradiation, quantitative and spatial distribution of the h.M.S.C. were studied. Histological analysis of mouse tissues confirmed the presence of radio-induced lesions in the irradiated fields. Following their infusion into nonirradiated animals, h.M.S.C. homed at a very low level to various tissues (lung, bone marrow, and muscles) and no significant engraftment was found in other organs. T.B.I. induced an increase of engraftment levels of h.M.S.C. in the brain, heart, bone marrow, and muscles. Abdominal irradiation (A.I.) as compared with leg irradiation (L.I.) increased h.M.S.C. engraftment in the exposed area (the gut, liver, and spleen). Comparison of two local irradiations has shown that (L.I.) as compared with (A.I.) increased h.M.S.C. engraftment in the exposed area. An increase of h.M.S.C. engraftment in organs outside the fields of the A.L.I. was also observed. Conversely, following L.I., h.M.S.C. engraftment was increased in the brain as compared with A.I.. This study shows that engraftment of h.M.S.C. in N.O.D./ S.C.I.D. mice with significantly increased in response to tissue injuries following T.B.I. with or without A.L.I.. A.L.I. induced an increase of the level of engraftment at sites outside the local irradiation field, thus suggesting a distant (abscopal) effect of radiation damage. This work supports the use of M.S.C. to repair damaged normal tissues following accidental irradiation and possibly in patients submitted to radiotherapy. (authors)

  6. Mass-charge-heat coupled transfers in a single cell of a proton exchange membrane fuel cell; Transferts couples masse-charge-chaleur dans une cellule de pile a combustible a membrane polymere

    Energy Technology Data Exchange (ETDEWEB)

    Ramousse, J.

    2005-11-15

    Understanding and modelling of coupled mass, charges and heat transfers phenomena are fundamental to analyze the electrical behaviour of the system. The aim of the present model is to describe electrical performances of a PEFMC according to the fluidic and thermal operating conditions. The water content of the membrane and the water distribution in the single cell are estimated according to the coupled simulations of mass transport in the thickness of the single cell and in the feeding channels of the bipolar plates. A microscopic model of a Gas Diffusion Electrode is built up to describe charges transfer phenomena occurring at the electrodes. Completed by a study of heat transfer in the Membrane Electrode Assembly, conditions and preferential sites of water vapor condensation can be highlighted. A set of measurements of the effective thermal conductivity of carbon felts used in fuel cells as porous backing layers have also been performed. Although the value of this parameter is essential for the study of heat transfer, it is still under investigation because of the strong thermal anisotropy of the medium. (author)

  7. L'oxyde de zinc par dépôt chimique en phase vapeur comme contact électrique transparent et diffuseur de lumière pour les cellules solaires

    OpenAIRE

    Faÿ, Sylvie

    2003-01-01

    Zinc oxide (ZnO) is a material that belongs to the family of Transparent Conductives Oxides (TCO). Its non-toxicity and the abundant availability in the Earth's crust of its components make it an ideal candidate as electrical transparent contact for thin-film amorphous and/or microcrystalline silicon solar cells. The Low-Pressure Chemical Vapour Deposition (LP-CVD) method allows one to obtain rough ZnO layers, which can effectively scatter the light that passes through them. This high scatter...

  8. L'oxyde de zinc par dépôt chimique en phase vapeur comme contact électrique transparent et diffuseur de lumière pour les cellules solaires

    OpenAIRE

    Faÿ, Sylvie; Shah, Arvind V.

    2005-01-01

    Zinc oxide (ZnO) is a material that belongs to the family of Transparent Conductives Oxides (TCO). Its non-toxicity and the abundant availability in the Earth’s crust of its components make it an ideal candidate as electrical transparent contact for thin-film amorphous and/or microcrystalline silicon solar cells. The Low-Pressure Chemical Vapour Deposition (LP-CVD) method allows one to obtain rough ZnO layers, which can effectively scatter the light that passes through them. This high scatter...

  9. L'apport des professionnels IST d'une cellule de veille dans l'appui à la stratégie et à l'animation scientifique et technique: retours d'expériences

    OpenAIRE

    Giovannini, F; De Mareschal, S.

    2010-01-01

    / Présentation réalisée lors d'une journée organisée par l'association des documentalistes du CNRS Go!doc. Les objectifs étaient de présenter la démarche de veille au Cemagref, son dispositif, son cadre (la DPV) ainsi que des exemples de réalisations en national et en local.

  10. In-situ study of the dendritic growth in lithium/polymer electrolyte-salt/lithium cells; Etude in-situ de la croissance dendritique dans des cellules lithium/POE-sel/lithium

    Energy Technology Data Exchange (ETDEWEB)

    Brissot, C.; Rosso, M.; Chazalviel, J.N. [Ecole Polytechnique, 91 - Palaiseau (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches

    1996-12-31

    The in-situ observation of dendritic growth in lithium/polymer electrolyte-LiTFSI/lithium battery cells shows that dendrites grow up with about the same rate as anion migration. Memory effects have been evidenced in cycling experiments and limit the dendrites length. An overall movement of the electrolyte due to variations of electrolyte concentration in the vicinity of the electrodes has been observed too. (J.S.) 13 refs.

  11. Développement de procédés pour des cellules photovoltaïques kesterite en couches minces à haut rendement et bas coût

    OpenAIRE

    Vauche, Laura

    2015-01-01

    Facing growing energy demand and increasing concerns about climate change and finite energy sources, solar energy use should increase. The future of the different photovoltaic technologies obviously depends on their power conversion efficiency and cost (summarized by the ratio cost per watt), but also on the elements availability. Thin films of earth-abundant kesterite, Cu2ZnSnS4 (CZTS), Cu2ZnSnSe4 (CZTSe) or Cu2ZnSn(S,Se)4 (CZTSSe), which can be manufactured with low-cost processes, are prom...

  12. Une approche décentralisée et adaptative de la gestion d'informations en vision ; application à l'interprétation d'images de cellules en mouvement

    OpenAIRE

    Boucher, Alain

    1999-01-01

    Cette thèse propose une nouvelle approche de la vision par ordinateur, insistant sur le rôle joué par les différentes informations et connaissances présentes dans un système intégré de vision. Ces connaissances peuvent être vues comme un but à atteindre dans la chaine de traitement ou comme un instrument pour guider ces différents traitement. Ce double rôle est mis en évidence en insistant sur la gestion des informations disponibles à tout moment pour effectuer la tâche de reconnaissance. Une...

  13. Effet de la O-GlcNAcylation sur la sensibilité du tamoxifène dans le cancer du sein dérivé des cellules MCF-7

    OpenAIRE

    Kanwal, Shahzina

    2013-01-01

    One of the hallmarks of cancer cells is to exhibit increased uptake and consumption of glucose.3-5% of the glucose entering into the cell leads to a minor pathway of the glucose metabolismknown as the hexosamine biosynthetic pathway (HBP). UDP-N-acetylglucosamine is the endproduct of HBP and is used as substrate by OGT (O-GlcNAc transferase) to modify diverserange of nuclear and cytoplasmic proteins with a recently characterized post-translationalmodification called O-GlcNAcylation. It corres...

  14. Influence of the impurity-defect and impurity-impurity interactions on the crystalline silicon solar cells conversion efficiency; Influence des interactions impurete-defaut et impurete-impurete sur le rendement de conversion des cellules photovoltaiques au silicium cristallin

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, S

    2007-05-15

    This study aims at understanding the influence of the impurity - defect interaction on the silicon solar cell performances. We studied first the case of single-crystalline silicon. We combined numerical simulations and experimental data providing new knowledge concerning metal impurities in silicon, to quantify the evolution of the conversion efficiency with the impurity concentration. Mainly due to the gettering effects, iron appears to be quite well tolerated. It is not the case for gold, diffusing too slowly. Hydrogenation effects were limited. We transposed then this study toward multi-crystalline silicon. Iron seems rather well tolerated, due to the gettering effects but also due to the efficiency of the hydrogenation. When slow diffusers are present, multi crystalline silicon is sensitive to thermal degradation. n-type silicon could solve this problem, this material being less sensitive to metal impurities. (author)

  15. Aggressive large cell lymphoma: early assessment of therapeutic efficacy by positron emission tomography; Lymphome agressif a grandes cellules: appreciation precoce de l'efficacite therapeutique par la TEP au [{sup 18}F]-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Itti, E.; Maignan, M. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Medecine Nucleaire, 94 - Creteil (France); Haioun, C.; Reyes, F. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service d' Hematologie Clinique, 94 - Creteil (France); Rahmouni, A. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Radiologie, 94 - Creteil (France)

    2004-07-01

    The international prognostic index is a well-established tool for stratifying patients with aggressive non-Hodgkin's lymphoma scheduled for tailored therapy. Early FDG-PET imaging could play a major predictive role for patient survival by providing functional information about lymphoma chemo-sensitivity. We present here the results of the interim analysis (about SD patients) of a prospective multi-centre study (national PHRC), the goals of which were to correlate PET response after 2 induction cycles 1) to the therapeutic response assessed by conventional diagnostic methods and 2) to event free survival and global survival. (author)

  16. Study and fabrication of solid oxide fuel cells through tape casting and co-sintering; Etude et realisation par coulage en bande et co-frittage de cellules de pile a combustible a oxydes solides

    Energy Technology Data Exchange (ETDEWEB)

    Grosjean, A

    2004-11-15

    This work is dedicated to the devising of a low-cost fabrication process of solid oxide fuel cells (SOFC). Technical requirements impose the shaping method: stripe casting as well as the materials used: Yttria-stabilized zirconia (YSZ), nickel and lanthanum manganite doped with strontium (LSM). In order to comply with environmental requirements the developed process uses an aqueous barbotine solvent. We get electrodes and the electrolyte separately, the use of an absorbent drying process has enabled us to join 3 layers to form an elementary cell with great interfacial homogeneity. The resistance of the cell to sintering has been improved through the symmetrization of the deformations of the cell. In order to interpret the low electrical properties of the cell and its quick damaging, transmission microscopy studies have been performed. These studies have shown 2 facts. First, 2 isolating phases appear at the cathode (at the LSM/YSZ interface) because of a too high sintering temperature and secondly, a quick clustering of nickel grains appears during cell operation that leads to a local loss of the nickel grid percolation. This problem has been solved by increasing the size of nickel oxide grains from 0.5 {mu}m to 3 {mu}m) to stabilize the microstructure. The issue of the reactivity at the LSM/YSZ interfaces was tackled in 2 different ways, we have tried to lower the sintering temperature by using a zirconia nano-powder first and then by replacing zirconia in the electrolyte by gadolinium-doped ceria. The use of zirconia nano-powder has failed to decrease sintering temperature while preserving the electrolyte density and the use of ceria has triggered instabilities that have not yet been solved. Despite all these drawbacks, this process allows the fabrication of an excellent anode/electrolyte interface. (A.C.)

  17. Deux curiosités historiques: l'hôpital civil et les cellules de Compostelle de l'asile d'aliénés de Cadillac

    OpenAIRE

    Bénézech, M.

    2011-01-01

    Abstract In 1617, the first duc d?Epernon founded Cadillac hospital and granted it financial autonomy on two conditions: 1) That 12 beds should serve for the free treatment of ill local people; 2) that 6 other beds should be used for the free accommodation for one or two nights of travelers and pilgrims on the road to Santiago de Compostella. The ?civil hospital? was the beginning of the Cadillac lunatic asylum, of which it was to become an ?annex?. Right up to its closure in 1972,...

  18. Cellules électrochimiques produisant du gaz : suivi de l'électrolyse par émission acoustique et effets de la mouillabilité des électrodes sur le flux des charges électriques

    OpenAIRE

    Brussieux, Charles

    2011-01-01

    Molten salts electrochemical processes, like fluorine and aluminium production processes produce bubbles on electrodes slightly wetted by an electrolyte. In those cells, the electrolyte convection is mainly induced by the motion of bubbles. Then, the residence time of gas is not under control and the modelling of such electrolysis still faces many challenges. This work begins with a collection of the information required to model gas-producing cells. We developed an electrochemical composite ...

  19. Etude expérimentale de la production de fer électrolytique en milieu alcalin: mécanisme de réduction des oxydes et développement d'une cellule

    OpenAIRE

    Allanore, Antoine

    2007-01-01

    Iron is one of the few metals which is not industrially produced by electrolysis. The electrowinning of iron metal from its oxides in alkaline solution has been studied to develop such an ironmaking route. Two approaches have been adopted. The first one concerns the evaluation of the reaction mechanism. The study of iron ions electrochemistry in alkaline media shows that the electrodeposition of iron metal is possible. The study of a single iron oxide particle reduction reveals that a reactio...

  20. Etude de la durabilité de cellules d'électrolyse de la vapeur d'eau à haute température : influence des paramètres de fonctionnement

    OpenAIRE

    Mansuy, Aurore

    2012-01-01

    This work is dedicated to the study on the long term behavior of a solid oxide electrolysis cell (SOEC). More specifically, the target is to identify and understand the influence of main working parameters on the cell durability in order to find the best compromise between performances and durability. The initial part of this work is to characterize electrochemically the single cell selected for the study, that is to say a cathode supported cell of the type LSFC/YDC/8YSZ/Ni-YSZ at different g...

  1. NANOMEDECINE EN ONCOLOGIE : Etude des Interactions Entre les Nanoparticules Activables par des Sources d'Energie Electromagnétique Externes et les Cellules Cancéreuses pour Elargir la Fenêtre Thérapeutique

    OpenAIRE

    Virginie, Simon,

    2009-01-01

    La compréhension des interactions entre les nanomatériaux et les entités biologiques est fondamentale pour développer des nanoproduits en oncologie. NBTXR3 (nanoparticule inerte d'oxyde d'hafnium) et protoporphyrine IX (Pp IX) nanotransporteur (nanoparticule de silice encapsulant le Pp IX, le monomère du Photofrin®) sont des nanoproduits, issus des plateformes Nanobiotix, développés pour élargir la fenêtre thérapeutique des traitements du cancer en utilisant des sources d'activation externe d...

  2. Study of the cetuximab-ionizing radiation association on a model of in vitro endothelial cells; Etude de l'association cetuximab-radiations ionisantes sur un modele de cellules endotheliales in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Vautravers-Dewas, C.; Rebucci, M.; Lansiaux, A. [Centre Oscar-Lambret, Inserm U837, Lab. de Pharmacologie Antitumorale, 59 - Lille (France); Peixoto, P. [Inserm U837, 59 - Lille (France); Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2009-10-15

    These data support the existence of functional signalling tracks downstream epidermal growth factor receptor (E.G.F.R.) in endothelial cells. But our in vitro model, in two dimensional calculations, did not allow to show a radiosensitivity by cetuximab. The study of functional consequences of the association cetuximab-irradiation treatment will be relevant in an in vitro three dimensional model and on xenografts. (N.C.)

  3. Feasibility of high-dose three-dimensional radiation therapy in the treatment of localised non-small-cell lung cancer; Irradiation conformationelle de haute dose dans les cancers bronchiques non a petites cellules localement evolues: etude de faisabilite

    Energy Technology Data Exchange (ETDEWEB)

    Belliere, A.; Girard, N.; Chapet, O.; Khodri, M.; Kubas, A.; Mornex, F. [Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Souquet, P.J. [Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Dept. de Medecine Respiratoire, 69 - Pierre-Benite (France)

    2009-07-15

    Purpose/ Chemoradiotherapy is the standard treatment of inoperable and/or non-resectable IIIA/B non-small-cell lung cancer (N.S.C.L.C.). Aware of the necessity to increase local control in locally advanced N.S.C.L.C., we analyzed the feasibility of high-dose three-dimensional conformal radiation therapy (3D-C.R.T.) in the treatment of localised N.S.C.L.C. Patients and methods: We undertook a retrospective analysis of consecutive patients with non-resectable N.S.C.L.C. treated with high-dose (74 Gy) standard-fractionation 3D-C.R.T., with particular attention to the relationship between lung and heart radiation-induced toxicities. Results: Fifty patients (41 males, 9 females) were included. A total of 35 (70%) patients received the planned total dose of 74 Gy. Patients irradiated to inferior doses interrupted the treatment because of limiting toxicities. Induction and concurrent chemotherapy was delivered to 39 (78%) and 14 (28%) patients, respectively. Eight (16%) patients experienced grade 3-4 acute lung toxicity, all of them having a history of pulmonary disease, a FEV1 below 1.6 L, and a lung V20 of at least 25%. Three (6%) patients were deemed to experience radiation-induced cardiac toxicity. Conclusions: This study assesses the feasibility of delivering a total dose of 74 Gy combined with chemotherapy in locally advanced N.S.C.L.C.. High lung and heart V20 increases the risk of radiation-induced lung and cardiac toxicity, the later being highly difficult to precisely assess, as late deaths are rarely documented, and responsibility of the treatment might be often underestimated. The precise evaluation of cardiac condition may be helpful to spare fragile patients from potentially toxic effects of high-dose radiation, especially in controlled trials. (authors)

  4. Synthesis, characterization and nano-structuration of poly-thiophene derivatives for organic photovoltaic solar cells; Synthese, caracterisation et nanostructuration de derives du polythiophene pour des applications en cellules photovoltaiques organiques

    Energy Technology Data Exchange (ETDEWEB)

    Berson, S

    2007-10-15

    This work is devoted to the synthesis of poly-thiophene derivatives with low bandgap and preserving high oxidation potential. Disubstituted thiophenes and 'Donor-Acceptor' bi-thiophenes were synthesized and then polymerized. The side chains of these polymers, donor or acceptor, were modified in order to tune the properties of material as well from the optical point of view as electrochemical. These polymers were also tested in blend with PCBM in bulk-heterojunction photovoltaic cells. Voc delivered by the devices showed a linear dependence according to the potential of oxidation of the polymers. Copolymers containing cyano-thiophene and alkyl- or alkoxy-thiophene showed values of 0.8 V. However, in spite of power conversion efficiency of 1 %, these performances remain lower than the one obtained with the P3HT. Optimizations in terms of morphology are certainly necessary. Indeed, the morphology of the active layer plays a key role in obtaining high power conversion efficiency. An original technique of nano-structuration of the polymer on a nano-metric scale was developed during this work, leading to the development of fibrillar P3HT. These nano-structures, presenting an important degree of order, are formed spontaneously in solution. Their rate compared to amorphous material is perfectly controllable and adjustable in solution and in solid state. Measurements of mobilities show a strong improvement of the transport of load within these fibrillar layers compared to a traditional film of P3HT obtained without annealing. Power conversion efficiencies of 3.6% on glass and 3.3 % on plastic were reached without annealing. (author)

  5. Light ions radiobiological effects on human tumoral cells: measurements modelling and application to hadron-therapy; Mesures et modelisation des effets radiobiologiques des ions legers sur des cellules tumorales humaines: application a l'hadrontherapie

    Energy Technology Data Exchange (ETDEWEB)

    Jalade, P

    2005-11-15

    In classical radiotherapy, the characteristics of photons interactions undergo limits for the treatment of radioresistant and not well located tumours. Pioneering treatments of patients at the Lawrence Laboratory at Berkeley has demonstrated two advantages of hadrons beams: the Relative Biologic Effect (the RBE) and the ballistic of the beams. Since 1994, the clinical centre at Chiba, has demonstrated successfully the applicability of the method. A physics group, managed by G. Kraft, at Darmstadt in Germany, has underlined the advantages of carbon beams. An European pool, called ENGIGHT (European Network for LIGHt ion Therapy) has been created in which the French ETOILE project appeared. The purpose of the thesis concerns measurements and models of 'in vitro' human cells survival. In the first part, the nowadays situation in particles interactions, tracks and cells structures and radiobiology is presented here. The second is devoted to the models based on the beam tracks and localization of the physical dose. Discussion of sensitivity to various parameters of the model has been realized with the help of numerical simulations. Finally the predictions of the improved model has been compared to experimental irradiations of human cells with argon and carbon beams of the GANIL machine. Conclusion of such study shows the performance and limits of a local model for predicting the radiobiological efficiency of light ions in hadron-therapy. (author)

  6. Introduction to the reliability study of IGBT switching cells under strong constraints; Introduction a l'etude de la fiabilite des cellules de commutation a IGBT sous fortes contraintes

    Energy Technology Data Exchange (ETDEWEB)

    Vallon, J.

    2003-12-15

    The reliability approach in power electronics is a complex problem including the coupling of current / voltage surges, physical and technological imperfections, from the die to the power circuit. First of all, we define a methodology based on the monitoring of a great number of components, during a long time campaign. Components are 600 V-50 A-20 kHz IGBT-diodes modules working in PWM inverter cells owing to an original opposition method. An exhaustive study of cell-switching failure modes allowed us to design a suitable and efficient protection. Afterwards, a complete reliability test bench was carried out with electrical and thermal monitoring. A preliminary screening protocol was also applied. The first results are presented in this thesis. (author)

  7. Ultra-sonografia intra-oral e transcutânea cervical no diagnóstico diferencial de celulite e abscessos periamigdalianos Intraoral and transcutaneous cervical ultrasound in the differential diagnosis of peritonsillar cellulitis and abscesses

    OpenAIRE

    Bernardo Cunha Araujo Filho; Flavio A. Sakae; Luiz Ubirajara Sennes; Rui Imamura; Marcus R. de Menezes

    2006-01-01

    OBJETIVOS: O objetivo deste estudo é determinar a especificidade, sensibilidade e a acurácia da ultra-sonografia (USG) intra-oral e transcutânea no diagnóstico de celulite e abscesso periamigdalianos. FORMA DE ESTUDO: Clínico Prospectivo. MATERIAL E MÉTODO: Trinta e nove pacientes foram atendidos no pronto-socorro de otorrinolaringologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo com diagnóstico clínico de celulite ou abscesso periamigdaliano. Em todos os p...

  8. Estudo clínico de celulite orbitária e pré-septal na infância Orbital and preseptal cellulitis in childhood: a clinical study

    OpenAIRE

    César Moreira Sampaio; Lívia Maria Bittencourt Nossa; Ana Paula Ramos; Renata Abreu Paim; Roberto Lorens Marback

    2001-01-01

    Objetivo: Estudar retrospectivamente aspectos clínicos e terapêuticos em crianças portadoras de celulite orbitária e pré-septal. Métodos: Foram analisados 52 prontuários de pacientes com idades variando de um mês a doze anos, internados no período compreendido entre 1990 e 1998, com quadro de celulite orbitária ou pré-septal. Resultados: Trauma foi o fator predisponente mais freqüente das celulites orbitárias e pré-septais na infância, seguido pela sinusite e causas não-definidas. As infecçõe...

  9. Simulation d'une structure générique RC-IGBT sans "tension de retournement" adaptée à l'intégration monolithique de cellules de commutation sur puce Si

    OpenAIRE

    Lale, Adem; Bourennane , Abdelhakim; El khadiry, Abdelilah; Richardeau, Frédéric

    2014-01-01

    Une structure IGBT à conduction inverse (RC- IGBT) qui intègre de manière monolithique un IGBT pour la conduction directe et un thyristor auto-amorçable pour la conduction inverse est proposée. Contrairement au RC-IGBT classique, cette nouvelle structure ne présente pas de snapback [1-2] en mode de conduction direct. Le fonctionnement du RC- IGBT que nous proposons a été étudié par des simulations physiques 2D en statique et en dynamique. La structure proposée est ensuite utilisée pour créer ...

  10. Hot laboratory in Saclay. Equipment and radio-metallurgy technique of the hot lab in Saclay. Description of hot cell for handling of plutonium salts. Installation of an hot cell; Laboratoire a tres haute activite de Saclay. Equipement et techniques radiometallurgiques du laboratoire a haute activite de Saclay. Description de cellules pour manipulation de sels de plutonium. Amenagement d'une cellule du laboratoire de haute activite

    Energy Technology Data Exchange (ETDEWEB)

    Bazire, R.; Blin, J.; Cherel, G.; Duvaux, Y.; Cherel, G.; Mustelier, J.P.; Bussy, P.; Gondal, G.; Bloch, J.; Faugeras, P.; Raggenbass, A.; Raggenbass, P.; Fufresne, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-07-01

    Describes the conception and installation of the hot laboratory in Saclay (CEA, France). The construction ended in 1958. The main aim of this laboratory is to examine fuel rods of EL2 and EL3 as well as nuclear fuel studies. It is placed in between both reactors. In a first part, the functioning and specifications of the hot lab are given. The different hot cells are described with details of the ventilation and filtration system as well as the waste material and effluents disposal. The different safety measures are explained: description of the radiation protection, decontamination room and personnel monitoring. The remote handling equipment is composed of cutting and welding machine controlled with manipulators. Periscopes are used for sight control of the operation. In a second part, it describes the equipment of the hot lab. The unit for an accurate measurement of the density of irradiated uranium is equipped with an high precision balance and a thermostat. The equipment used for the working of irradiated uranium is described and the time length of each operation is given. There is also an installation for metallographic studies which is equipped with a manipulation bench for polishing and cleaning surfaces and a metallographic microscope. X-ray examination of uranium pellets will also be made and results will be compared with those of metallography. The last part describes the hot cells used for the manipulation of plutonium salts. The plutonium comes from the reprocessing plant and arrived as a nitric solution. Thus these cells are used to study the preparation of plutonium fluorides from nitric solution. The successive operations needed are explained: filtration, decontamination and extraction with TBP, purification on ion exchangers and finally formation of the plutonium fluorides. Particular attention has been given to the description of the specifications of the different gloveboxes and remote handling equipment used in the different reaction steps and manipulations. (M.P.)

  11. Accuratezza diagnostica dell'ecografia con mezzo di contrasto nel predire l'evoluzione a breve termine in pazienti con morbo di Crohn

    OpenAIRE

    Fanigliulo, Libera

    2012-01-01

    Obiettivi. L’ecografia con mezzo di contrasto (CEUS) può fornire informazioni sulla microvascolarizzazione della parete intestinale nella malattia di Crohn. L’infiammazione della parete intestinale non sembra essere correlata alla quantità di parete vascolarizzata (studi di pattern di vascolarizzazione, SVP) ma all’intensità del flusso di parete in un determinato periodo di tempo (studi di intensità-tempo, SIT). Scopo dello studio è valutare se gli studi SVP e/o SIT mediante CEUS siano in gr...

  12. Imaging of Orbital Infections

    Directory of Open Access Journals (Sweden)

    Seyed Hassan Mostafavi

    2010-05-01

    Full Text Available Preseptal and orbital cellulitis occur more commonly in children than adults. The history and physical examination are crucial in distinguishing between preseptal and orbital cellulitis. The orbital septum delineates the anterior eyelid soft tissues from the orbital soft tissue. Infections anterior to the orbital septum are classified as preseptal cellulitis and those posterior to the orbital septum are termed orbital cellulitis. "nRecognition of orbital involvement is important not only because of the threatened vision loss associated with orbital cellulitis but also because of the potential for central nervous system complications including cavernous sinus thrombosis, meningitis, and death. "nOrbital imaging should be obtained in all patients suspected of having orbital cellulitis. CT is preferred to MR imaging, as the orbital tissues have high con-trast and the bone can be well visualized. Orbital CT scanning allows localization of the disease process to the preseptal area, the extraconal or intraconal fat, or the subperiosteal space. Axial CT views allow evaluation of the medial orbit and ethmoid sinuses, whereas coronal scans image the orbital roof and floor and the frontal and maxillary sinuses. If direct coronal imaging is not possible, reconstruction of thin axial cuts may help the assessment of the orbital roof and floor. Potential sources of orbital cellulitis such as sinusitis, dental infection, and facial cellulitis are often detectable on CT imaging. "nIn this presentation, the imaging considerations of the orbital infections; including imaging differentiation criteria of all types of orbital infections are reviewed.

  13. Parasitoses intestinais se associam a menores índices de peso e estatura em escolares de baixo estrato socioeconômico Parasitosis intestinales se asocian con menores índices de peso y estatura en niños de bajo nivel económico Intestinal parasitoses are associated with lower values of weight and height in school-aged children from low socioeconomic level

    OpenAIRE

    Humberto B. Araujo Filho; Miriam S. Carmo-Rodrigues; Carolina Santos Mello; Lígia Cristina F. L Melli; Soraia Tahan; Mauro Batista de Morais

    2011-01-01

    OBJETIVO: Avaliar a prevalência de parasitoses intestinais, correlacionando-as com os fatores socioeconômicos e ambientais, peso, estatura e hemoglobina, em crianças de dois estratos socioeconômicos, no município de Osasco (SP). MÉTODOS: Estudo transversal, comparando 84 crianças de seis a dez anos, residentes em área sem saneamento básico e moradia precária, com 35 crianças de escola particular no mesmo município, que possuíam boas condições socioeconômicas e de moradia. Excluíram-se aquelas...

  14. Expression und Regulation des antimikrobiellen Cathelicidin-Peptids LL-37 in humanen Kolonepithelzellen, Monozyten und PBMC

    OpenAIRE

    Iffland, Konrad

    2005-01-01

    Butyrat ist die wichtigste kurzkettige Fettsäure im Kolon und dient der normalen Schleimhaut als trophischer Faktor. Butyrat hat paradoxe Effekte auf Epithelzellen des Kolons: Hauptenergieträger und Wachstumsstimulator normaler Mukosa einerseits, Proliferationshemmer und Apoptoseinduktor kolorektaler Karzinomzellen in vitro andererseits. Butyrat kann zudem die Immunfunktionen der Schleimhaut modulieren. Die einzellige Schicht des Dickdarmepithels ist eine aktive Barriere gegen die intestinale...

  15. Recidiverende halscellulitis hos nyfødt forårsaget af gruppe B-streptokokker

    DEFF Research Database (Denmark)

    Rasmussen, Annett Helleskov; Fenger-Grøn, Jesper

    2011-01-01

    Group B streptococci are an important cause of neonatal infection, and cellulitis is rarely found to be the clinical manifestation. In the present case a premature boy developed cellulitis and antibiotic sensitive group B streptococci were detected in blood culture. Despite pertinent treatment for...... 14 days he developed two relapses. At last antibiotic treatment was continued for a period of six weeks with no further relapse. To our knowledge no cases of relapse of neonatal group B streptococcal cellulitis in spite of recommended dose and duration of antibiotic treatment have been published...

  16. Détection d'adduits benzo[a]pyrène-ADN dans les cellules mononucléaires périphériques d'ouvriers de cokeries : corrélation à la capacité de fixation à l'ADN

    OpenAIRE

    Rojas, Margarita; Alexandrov, Kroum; Auburtin, Guy; Mayer, Lucienne; Mahieu, Bernard; Wastiaux-Denameur, Agnès; Sebastien, Patrick; Bartsch, Helmut

    1994-01-01

    Un des objectifs des enquetes d'epidemiologie moleculaire sur le risque de cancer du poumon est de caracteriser le role que jouent les facteurs d'hotes dans les evenements critiques menant a l'activation de cancerogenes qui, eux, peuvent provoquer des lesions a l'ADN humain.La formation d'adduits de l'ADN etant consideree comme un evenement critique de la tumorigenese, on estime que les variations interindividuelles (genetiquement determinees) de l'activation de cancerogenes sont un important...

  17. Quantitative analysis of fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images on five patients irradiated for a non-small-cell bronchial cancer; Analyse quantitative d'images de TEP au fluorodesoxyglucose, au fluoromisonidazole et a la fluorothymidine chez cinq patients irradies pour un cancer bronchique non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Thureau, S.; Dubray, B. [Departement de radiotherapie et physique medicale, centre Henri-Becquerel, Rouen (France); Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Modzelewski, R.; Lelandais, B.; Edet Sanson, A.; Gardin, I.; Vera, P. [Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Departement de medecine nucleaire, centre Henri-Becquerel, Rouen (France)

    2011-10-15

    As fluorodeoxyglucose-PET (positron emission tomography) is used for the planning of non-small-cell bronchial carcinoma radiotherapy in order to help to define the gross tumour volume (GTV), and as new tracers have been developed to define a biological target volume, the authors report the comparison of several thresholding methods by using fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images. They notice important differences between the delineated volumes. Short communication

  18. In vitro modulation of radiation-induced FAS-related apoptosis in CD34{sup +} progenitor cells by combination cytokines; Reduction de l'apoptose radio-induite impliquant le recepteur FAS au niveau des cellules hematopoietiques CD34{sup +} par une combinaison de cytokines

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Soutif, A.; Herodin, F

    1998-07-01

    Combination cytokines such as SCF, Flt-3 ligand, IL-3 and thrombopoietin can modulate Fas mRNA expression by in vitro irradiated CD34{sup +} cells which results in a moderate decrease of apoptotic ratio and an improved rate of clonogenicity of the irradiated progenitors. (authors)

  19. Etude et mise au point d'une cellule à électrodes poreuses pour la récupération d'ions métalliques en solution/study of an electrochemical cell with porous electrodes for an environmental application

    OpenAIRE

    Vande Vyver, Olivier

    2008-01-01

    Les procédés électrochimiques présentent beaucoup d’avantages dans le domaine du traitement et de la récupération de matière d’effluents industriels. Cependant, dans le cas de solutions diluées en ions métalliques, les électrodes classiques sont fortement limitées par leur efficacité ainsi que par leur taille. Dès lors, les électrodes poreuses, de par leur surface spécifique importante et de par leur structure particulière qui améliore le transport de matière et donc l’efficacité de l’électro...

  20. In vitro cytotoxic effects of PM{sub 2.5} from the city of Abidjan (Ivory Coast) on human A549 lung cells; Effets cytotoxiques in vitro des PM{sub 2,} {sub 5} de la ville d'Abidjan (Cote-d'Ivoire) sur des cellules pulmonaires humaines

    Energy Technology Data Exchange (ETDEWEB)

    Kouassi, Kouakou-Serge [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire); Billet, Sylvain; Garcon, Guillaume; Verdin, Anthony; Courcot, Dominique; Shirali, Pirouz [Universite Lille Nord de France, Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, EA 4492 MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Diouf, Amadou [Laboratoire de Toxicologie, Faculte de Medecine Pharmacologie Odontologie, Universite Cheikh Anta Diop, Dakar (Senegal); Cazier, Fabrice [Universite Lille Nord de France, Lille (France); Centre Commun de Mesures, MREI 1, Universite du Littoral Cote d' Opale, Dunkerque (France); Djaman, Joseph [Universite Cocody-Abidjan et Institut Pasteur, Abidjan (Cote d' Ivoire)

    2012-01-15

    Epidemiological studies associate air pollution, especially particulate, increased morbidity and mortality from respiratory and cardiovascular origin . Africa, which has an urbanization rate among the highest in the world, is particularly exposed. The 'Initiative on the air quality in Sub-Saharan Africa' showed the importance of atmospheric concentrations of certain pollutants such as nitrogen oxides, sulfur dioxide and particulate matter (PM{sub 10}). Like the great capitals of Africa, Abidjan, economic capital and most industrialized city of Ivory Coast is facing an air pollution from industrial-urban and health consequences for its population of nearly 6 million inhabitants. To better understand the mechanisms of action resulting from pulmonary exposure to particulate atmospheric aerosols, we proposed: (i) to collect atmospheric particles (PM{sub 2.5}) using high volume cascade impaction in the District of Abidjan in three influences (rural, urban or industrial), (ii) to determine their main physicochemical, (iii) assess their cytotoxicity and their role in the induction of oxidative damage in a model of human lung cells (A549) in culture. The chemical composition of the atmospheric particles revealed their heterogeneity, and many inorganic (e.g. Al, Ca, Fe, Mn, Zn, Ni, Cr, Cu, Pb, Mg) and organic compounds (e.g. paraffins) were quantified at the three sites. Their effect concentrations (EC) to 10 and 50% on the A549 were as follows: influence rural: EC{sub 10} = 5.91 {mu}g/cm{sup 2} and EC{sub 50} 29.55 {mu}g/cm{sup 2}, urban influence: EC{sub 10} = 5 .45 {mu}g/cm{sup 2} and EC{sub 50} = 27.23 {mu}g/cm{sup 2}, and industrial influence: EC{sub 10} = 6.86 {mu}g/cm{sup 2} and EC{sub 50} = 34.29 {mu}g/cm{sup 2}. Exposure of A549 cells to Abidjan city's PM samples for 24, 48 or 72 hours to their EC{sub 10} or EC{sub 50} induced oxidative damage, as demonstrated by the formation of malon-dialdehyde, changes in enzyme activity of superoxide dismutase and alteration of glutathione status. (authors)

  1. L’hypertension artérielle et les désordres vasculaires induits par l'érythropoïétine recombinante humaine et le système rénine-angiotensine-aldostérone : Effet de l’exercice et des cellules T régulatrices

    OpenAIRE

    Barhoumi, Tlili,

    2011-01-01

    Hypertension (HTN) is one of the most frequent disease and is of greatest concern in Western countries.HTN is often associated with overweight, kidney, heart and endocrine system disease. Vasculardisorders, associated with HTN induced by erythropoietin (r-HuEPO) treatment in chronic kidneydisease or in case of disruption of the renin-angiotensin-aldosterone system (RAAS), associated increasein arterial stiffness, endothelial dysfunction, unbalanced endothelin-1/nitric oxide ratio (ET-1/NO) an...

  2. Bulky PAH-DNA induced by exposure of a co-culture model of human alveolar macrophages and embryonic epithelial cells to atmospheric particulate pollution; Adduits encombrants a l'ADN dans des cocultures de cellules pulmonaires humaines exposees a une pollution atmospherique particulaire

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, Imane; Garcon, Guillaume; Billet, Sylvain; Shirali, Pirouz [Universite Lille Nord de France - Lille (France); Unite de Chimie Environnementale et Interactions sur le Vivant, MREI, Universite du Littoral Cote d' Opale, Dunkerque (France); Andre, Veronique; Le Goff, Jeremie; Sichel, Francois [GRECAN, Universite de Caen Basse-Normandie et centre Francois Baclesse, Caen (France); Roy Saint-Georges, Francoise; Mulliez, Philippe [Service de Pneumologie, Hopital Saint-Philibert, GHICL, Lille (France)

    2012-01-15

    Because of their deep penetration in human lungs, fine airborne particulate matter were described as mainly responsible for the deleterious effects of exposure to air pollution on health. Organic constituents are adsorbed on particles surface and, after inhalation, some (polycyclic aromatic hydrocarbons, PAHs) can be activated into reactive metabolites and can bind to DNA. The formation of bulky DNA adducts has been researched after exposure of mono-and co-cultures of alveolar macrophages (AM) and human embryonic human lung epithelial (L132), to fine air pollution particulate matter Air samples have been collected with cascade impactor and characterized: size distribution (92.15% < 2.5{mu}.m), specific surface area (1 m{sup 2}/g), inorganic (Fe, AI, Ca, Na, K, Mg, Pb, etc.) and organic compounds (PAHs, etc.). {sup 32}P post-labeling method was applied to detect bulky DNA adducts in AM and L132, in mono-and co-cultures, 72 h after their exposure to atmospheric particles at their Lethals and Effects concentrations or (LC or CE) to 50% (i.e. MA: EC{sub 50} = 74.63 {mu}g/mL and L132: LC-5-0 = 75.36 {mu}g/mL). Exposure to desorbed particles (MA: C1= 61.11 {mu}g/mL and L132 : C2 = 61.71 {mu}g/mL) and B[a]P (1 {mu}M) were included. Bulky PAH-DNA adducts were detected in AM in mono-culture after exposure to total particles (Pt), to B[a]P and desorbed particles (Pd). Whatever the exposure, no DNA adduct was detected in L132 in mono-culture. These results are coherent with the enzymatic activities of cytochrome P450 l Al in AM and L132. Exposure of co-culture to Pt, or Pd induced bulky adducts to DNA in AM but not in L132. Exposure to B[a]P alone has altered the DNA of AM and L132, in co-culture. Exposure to Pt is closer to the environmental conditions, but conferred an exposure to amounts of genotoxic agents compared to studies using organic extracts. The formation of bulky DNA adducts was nevertheless observed in AM exposed to Pt, in mono- or co-culture, indicating that they were competent in terms of metabolic activation of PAHs. The DNA damage in the L132 in co-culture following exposure to B[a]P have suggested that some PAH metabolites generated by the MA could be have a genotoxic action on L132. (authors)

  3. Etude d'une décharge hors équilibre à pression atmosphérique pour des applications biomédicales : physique de la décharge, cinétique de la production des espèces réactives lors de l'interaction avec des cellules et des tissus vivants

    OpenAIRE

    Riès, Delphine

    2014-01-01

    Over the past decade, a new type of non-equilibrium discharge at atmospheric pressure has attracted growing interest, given the ability to produce a plasma extending in ambient air close to room temperatures. These plasma jets, often based on a dielectric barrier discharge type of reactor, are interesting on their physicochemical property perspectives. In addition, these cold plasma jets have the advantage of allowing applications to heat sensitive materials, creating a new field of research,...

  4. DIANE, a simulation code for the interaction of neutrons with living tissues. Application to low doses of fast neutrons on human tumoral cells; DIANE, un code de simulation de l'interaction des neutrons avec la matiere vivante. Applications aux faibles doses de neutrons rapides sur des cellules tumorales humaines

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, M.L

    2003-07-15

    Our work deals with the irradiation of cells and living tissues by 14 MeV neutrons at very low doses (a few 10{sup -2} Gy). Such experiments require an accurate knowledge of the values of neutron dose rates and fluences at the level of cell cultures. We have performed measurements of fluence rates through an activation method applied to gold and copper foils. The fluence rate is deduced from the gamma rays emitted by the irradiated foils. Neutron doses and dose rates have been measured through varied methods: PIN diodes, ionization tissue equivalent chambers, and Geiger-Mueller counters. We have designed the DIANE code to simulate the impact of energetic neutrons on cells. This code can be used with isolated cells or macroscopic tissues, it takes into account the roles of the ionisation electrons produced by recoil nuclei entering the cell. This point is all the more important since recent works have highlighted the impact of very low energy electrons on DNA. (A.C.)

  5. Himert: industrial calibration of type S, B and C thermocouples by comparison to metal - carbon eutectic cells: interest and perspectives; Etalonnage industriel de couples thermoelectriques type S, B et C par comparaison a des cellules eutectiques metal - carbone: interet et perspective

    Energy Technology Data Exchange (ETDEWEB)

    Fourrez, S.; Bailleul, G. [Thermocoax SASn 61 - Flers (France); Morice, R. [Laboratoire National de Metrologie et d' Essais (LNE), 75 - Paris (France); Machin, G. [National Physical Lab., Teddington (United Kingdom)

    2003-07-01

    For a long time temperature calibration laboratories have calibrated temperature sensors (resistance thermometers and thermocouples) by comparison to fixed point cells (between 0 deg C to 961.78 deg C) or by comparison to standard sensors in an homogenous and stable environment. For the calibration by comparison to fixed point cells uncertainties are small enough and almost satisfy industrials needs. Uncertainties become more important for calibration by comparison at high temperature (> 1000 deg C). Due to the standard calibration uncertainties it is very difficult for calibration laboratories to guaranty class 1 for the type R and S thermocouples up to 1600 deg C. Moreover calibration of type C thermocouples (Tungsten-Rhenium) up to 2000 deg C can not be performed by industrial laboratories. Metal-Carbon eutectic cells which will be developed during the HIMERT project, will help to reduce these uncertainties and at the same time will offer primary and industrial laboratories new calibration facilities. In addition Metal-Carbon eutectic cells can also be made into blackbody sources. These can be used to greatly improve traceability to industry and help difficult industrials measurement problems such as process control while viewing through continually contaminating windows. (authors)

  6. Air breath control radiotherapy in severe insufficiency respiratory patients with N.S.C.L.: application for deformable registration method in thoracic radiotherapy; Radiotherapie avec blocage respiratoire pour les grands insuffisants respiratoires atteints d'un carcinome pulmonaire non a petites cellules (Protocole RESPI 2000): application a la modelisation des deformations d'organes par recalage deformable

    Energy Technology Data Exchange (ETDEWEB)

    Sarrut, D.; Pommier, P.; Carrie, C. [Centre Leon-Berard, Dept. de Radiotherapie, CREATIS, Unite CNRS 5515, Inserm 630, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, Dept. de Biostatistique, 69 - Lyon (France)

    2006-11-15

    Purpose. Using deformable registration methods from a phase two clinical study of air breath control during radiotherapy in patients suffering from severe respiratory insufficiency and non-small cell lung carcinoma. Patients and methods, Between April 2002 and November 2005, 22 patients with severe respiratory insufficiency were treated with curative intent by conformal therapy combined with active breathing control. Results. After a mean of follow-up of 22 months, the local control rate is 28% and the method is feasible despite the severe respiratory insufficiency. However the overall survival is still poor due to metastatic widespread. For the second part of the study, the clinical protocol was also used for two studies using deformable registration methods. In the first study, a deformable registration method has been developed in order to register several breath-hold 3D CT of the same patient acquired at several days of interval. It allowed quantifying the inter-fraction breath-hold reproducibility by analysing the resulting displacement field. For 6 patients, the breath-hold was effective, while for 2 patients, motion greater than 10 mm were detected. The second study aimed to simulate 4D images from 3D breath-hold images. Developing an ad-hoc methodology based on the interpolation of 3D dense deformation fields performed it. The approach has been validated with expert selected landmarks, with accuracy lower than 3 mm. Conclusion. ABC is feasible, even in case of severe insufficiency respiratory syndrome but metastatic widespread disease is still a major challenge even with an acceptable local control rate without serious side effects: regarding the deformable registration method. Such artificial 4D images could allow decreasing the dose need to acquire a full 4D image, to simulate irregular breathing pattern and to be used for 4D dosimetry planning. (author)

  7. Study of the action of a phosphonate additive on steel scale deposit and corrosion in the hydrodynamic conditions of a channel flow cell; Etude de l'action d'un additif phosphone sur l'entartrage et sur la corrosion de l'acier dans les conditions hydrodynamiques d'une cellule a canal

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, C.

    2000-10-17

    In cooling systems, an improved control of scale deposit and corrosion processes is a major challenge and an realistic evaluation tool for water treatments is of the utmost economic importance. In this study, a channel flow cell was used to allow in-situ electrochemical measurements in well defined electrolyte tube flowing conditions. An expression of the mass transfer towards the electrode was established where the diffusion-limited current is a function of Re{sup 1/3} in the laminar regime and was verified experimentally using the redox couples Fe[CN]{sub 6}{sup 4-}/ Fe[CN]{sub 6}{sup 3-} and O{sub 2}/OH{sup -}. This hydrodynamically controlled experimental device was developed to investigate scale deposit processes and to evaluate scale inhibitor efficiency using a electrochemical quartz crystal microbalance. Experiments were performed on three different waters, at various flow rates and temperatures. The efficiency of a well known phosphonate (HEDP) was tested at different concentrations and an optimum concentration could be established (0.7 mg dm{sup -3}). The effect of additive injection during the scale formation as well as the influence of flow rate on the inhibiting efficiency were evaluated. The anti-scale additive was shown to be more effective in the turbulent regime. HEDP has shown a strong effect on inhibiting crystal growth and that affected the morphology of CaCO{sub 3} crystals. The HEDP effect on protecting carbon steel against corrosion was also studied in mineral water containing Ca{sup 2+} ions. It was found that anti-corrosion effect of HEDP is enhanced by the presence of calcium in solution and that is due to the formation of an HEDP-Ca{sup 2+} complex, which adsorbs onto the metallic surface and protects it from dissolution. (author)

  8. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  9. Synthesis of nano-particles by soft chemistry: structural, morphological and dimensional control. Studies of the electrochemical properties (towards dyes solar cells); Synthese de nanoparticules par chimie douce: controle structural, morphologique et dimensionnel. Etudes des proprietes electrochimiques (vers les cellules solaires a colorants)

    Energy Technology Data Exchange (ETDEWEB)

    Cassaignon, S.; Koelsch, M.; Jolivet, J.P. [Paris-6 Univ. Pierre et Marie Curie, Chimie de la Matiere Condensee de Paris, CNRS UMR 7574, 75 - Paris (France)

    2006-07-01

    In this work are described the electrochemical behaviour of different TiO{sub 2} films (anatase, brookite and rutile) in aqueous solution and the influence of the parameters as the crystal structure and the morphology on the electrochemical answer. To complete this study, the capacity of the double layer has been measured by impedance spectroscopy. Voltage measurements of TiO{sub 2} sensitized by a dye will allow to discuss the reversibility of the system and the rearrangement mechanisms. At last, the influence of the nature of the TiO{sub 2} particles (anatase, rutile and brookite) on the photovoltage has been studied in order to estimate their interest for photovoltaic devices. (O.M.)

  10. L’immunité innée dans le diabète sucré

    OpenAIRE

    Simoni, Yannick

    2013-01-01

    Le diabète de type 1 (T1D) est une maladie auto-immune caractérisée par la destruction des cellules β du pancréas par les lymphocytes T auto-réactifs. Durant ma thèse, nous nous sommes intéressés au rôle des cellules de l’immunité innée dans le T1D à l’aide d’un modèle murin de la maladie : la souris NOD. Au contraire des cellules du système adaptatif (lymphocytes T et B), les cellules de l’immunité innée constituent la première ligne de défense de l’organisme lors d’une infection. Cette popu...

  11. Omfalitis med fatal udgang hos en nyfødt dreng

    DEFF Research Database (Denmark)

    Debes, Nanette M M Mol; Dahl, Marianne; Jonsbo, Finn

    2008-01-01

    Omphalitis is a serious condition with important morbidity and mortality, especially in developing countries. The most commonly involved micro-organisms are Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. We describe a Danish patient with cellulitis...

  12. Lymphadenitis

    Science.gov (United States)

    Lymph node infection; Lymph gland infection; Localized lymphadenopathy ... Untreated lymphadenitis may lead to: Abscess formation Cellulitis (a skin infection) Fistulas (seen in lymphadenitis that is due to tuberculosis) Sepsis (bloodstream infection)

  13. Osteomyelitis

    Science.gov (United States)

    ... Kids For Parents MORE ON THIS TOPIC MRSA Staph Infections Dealing With Cuts First Aid & Safety Center Cellulitis ... Care Dealing With Broken Bones Osteomyelitis Hand Washing Staph Infections MRSA Bones, Muscles, and Joints Contact Us Print ...

  14. Toxic Shock Syndrome (For Parents)

    Science.gov (United States)

    ... can affect someone who has any type of staph infection , including pneumonia, an abscess, a skin or wound ... Talking to Your Child About Menstruation Cellulitis MRSA Staph Infections What Are Germs? Why Is Hand Washing So ...

  15. Hib Photos

    Science.gov (United States)

    ... St. Paul, Minnesota Cerebrospinal fluid culture positive for Haemophilus influenzae , type b (Gram stain) www.vaccineinformation.org/photos/hib_aap001.jpg Copyright American Academy of Pediatrics Haemophilus influenzae type b. Cellulitis of the arm proven by blood culture ...

  16. The use of differential scintigraphy in the clinical diagnosis of osseous and soft tissue changes affecting the diabetic foot

    International Nuclear Information System (INIS)

    Prompt recognition of cellulitis, osteomyelitis, diabetic osteolysis, Charcot neuroarthropathy, septic synovitis, and deep plantar abscesses in the diabetic foot is essential because the therapy is drastically different. Differential diagnosis has been greatly facilitated by recently developed scanning techniques

  17. An investigation of the possibility to replace the rabbit pyrogen test by an in vitro test

    NARCIS (Netherlands)

    Gommer AM; Donders LAM; LGM

    1998-01-01

    The classical test for the detection of pyrogenic contaminations in pharmaceuticals is the rabbit pyrogen test. The most frequently occuring and most important pyrogenic contamination in biological and biotechnological pharmaceutical preparations are bacterial endotoxins, originating from the cellul

  18. [Omphalitis with fatal outcome in new-born baby boy

    DEFF Research Database (Denmark)

    Debes, N.M.; Dahl, M.; Jonsbo, F.

    2008-01-01

    Omphalitis is a serious condition with important morbidity and mortality, especially in developing countries. The most commonly involved micro-organisms are Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. We describe a Danish patient with cellulitis, sev...

  19. Red Flags For Necrotizing Fasciitis: A Case Control Study

    OpenAIRE

    Khalid Al Alayed; Charlie Tan; Nick Daneman

    2015-01-01

    Objective: to examine the diagnostic accuracy of traditional ‘red flags’ for necrotizing fasciitis (NF) on history and physical examination. Methods: retrospective study of all cases of NF admitted to a large tertiary care hospital between January 1 2004 and December 31 2013, each matched to two control patients with cellulitis. We determined the diagnostic test characteristics of clinical features for distinguishing NF from cellulitis, with emphasis on positive (LR+) and negative (LR-) li...

  20. Tumor-heterogenitet: Betydning af klon-evolution under cancersygdomme

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen

    2013-01-01

    De senere års cancerforskning viser, at cellulær evolution er afgørende for forståelse af sygdomsudviklingen, og sandsynligvis også for fremtidig behandling af cancer hos dyr og mennesker.......De senere års cancerforskning viser, at cellulær evolution er afgørende for forståelse af sygdomsudviklingen, og sandsynligvis også for fremtidig behandling af cancer hos dyr og mennesker....

  1. Analisis Pengaruh Ekuitas Merek (Brand Equity) terhadap Kepuasan Konsumen Nexian pada Mahasiswa Universitas Negeri Medan

    OpenAIRE

    Lubis, Adelina

    2011-01-01

    Nexian is one of mobile phone brand in the market which continues to innovate in order to make a competitive and improve the trade. The company realize that satisfaction is very important for consument, because of that Nexian continues to improve the quality of the brand because to improve consumers’ satisfaction. The main customers of Nexian celluler are the students University. The students at the State University of Medan who are consument of the Nexian celluler phone (school year 2007-201...

  2. Studying a disease with no home--lessons in trial recruitment from the PATCH II study.

    LENUS (Irish Health Repository)

    Thomas, Kim S

    2010-01-01

    Cellulitis is a very common condition that often recurs. The PATCH II study was designed to explore the possibility of preventing future episodes of cellulitis, with resultant cost savings for the NHS. This was the first trial to be undertaken by the UK Dermatology Clinical Trials Network. As such, it was the first to test a recruitment model that involved many busy clinicians each contributing just a few patients.

  3. Randomized comparison of ceftazidime versus clindamycin-tobramycin in the treatment of obstetrical and gynecological infections.

    OpenAIRE

    Blanco, J D; Gibbs, R. S.; Duff, P.; Castaneda, Y S; St Clair, P J

    1983-01-01

    A randomized comparison of ceftazidime versus clindamycin-tobramycin was performed for the treatment of obstetrical and gynecological infections. Entry criteria were an oral temperature of greater than or equal to 38 degrees C and a clinical diagnosis of endometritis, salpingitis, or pelvic cellulitis after hysterectomy. All patients with endometritis had cultures of intrauterine material obtained via a transcervical single-lumen catheter. The patients with pelvic cellulitis had material from...

  4. Cervical celullitis in broiler chickens for Escherichia coli/
    Celulite cervical em frangos de corte causada por Escherichia coli

    OpenAIRE

    Ivens Gomes Guimarães; Milene Martins Berbel; Marcia Marinho Luzardo; Werner Okano; Claudia Yurika Tamehiro; Benito Guimarães de Brito

    2002-01-01

    In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frango...

  5. Place de la structure génétique de l'espèce Escherichia coli dans l'état de son commensalisme intestinal et dans l'expression de sa virulence.

    OpenAIRE

    Smati, Mounira

    2014-01-01

    Escherichia coli est le commensal aérobie le plus fréquent du tube digestif de l’homme et des animaux à sang chaud et le bacille à Gram négatif pathogène opportuniste le plus souvent impliqué dans les infections intestinales et extra intestinales de l’homme. C’est une espèce clonale chez laquelle 4 groupes phylogénétiques principaux, A, B1, B2 et D ont été décrits. L’objectif de cette thèse est d’étudier l’adaptation de E. coli et les rapports de cette adaptation avec la structure génétique d...

  6. Il lungo viaggio dell’Orthomixovirus A/goose/Guangdong/2/96(H5N1

    Directory of Open Access Journals (Sweden)

    Guglielmo Gargani

    2007-06-01

    Full Text Available INTRODUZIONE La peste aviaria ed i virus dell’influenza Nel 1878 E.Perroncito1 descrisse una grave malattia gastro-intestinale dei polli a carattere epidemico, che denominò peste aviaria; nel 1901 Centanni e Savonuzzi, mediante prove di filtrazione, ne dimostrarono l’origine virale. Oltre mezzo secolo più tardi, nel 1955, le migliorate metodiche virologiche misero in stretta relazione questo virus con il tipo A del virus influenzale; ambedue furono classificati qualche anno dopo come Orthomixovirus, tipo A. Fra questi virus esistono strette affinità virologiche e percorsi epidemiologici legati fra loro, ma la sintomatologia intestinale della peste aviaria è ben diversa da quella respiratoria dell’uomo e di qualche altro mammifero. Nel 1931 Shope

  7. Omics of the Bifidobacterium genus: from genes to function

    OpenAIRE

    Milani, Christian

    2015-01-01

    Il genere Bifidobacterium comprende 48 taxa e rappresenta uno dei gruppi batterici dominanti del tratto gastrointestinale di numerosi insetti sociali ed animali, risultando particolarmente prevalente durante le prime fasi dello sviluppo neonatale. Dalla loro prima identificazione all’inizio del 20° secolo, la loro importanza come membri del microbiota intestinale umano (inteso come la popolazione batterica totale presente nel tratto gastrointestinale dell’uomo) ha continuato a crescere ed ora...

  8. Genetic adaptation of bifidobacteria to the human gut: insights from genomics and transcriptomics analyses

    OpenAIRE

    Duranti, Sabrina

    2015-01-01

    I bifidobatteri sono batteri Gram positivi che appartengono al phylum degli Actinobacteria, caratterizzati dall’avere alto contenuto in GC nel loro DNA, dall’essere non mobili, asporigeni e anaerobi. I bifidobatteri sono parte del microbiota intestinale umano dove sono ritenuti in grado di esplicare degli effetti benefici sull’ospite. Nell’intestino i bifidobatteri sono in grado di influenzare la fisiologia, lo stato di salute e la risposta immunitaria dell’ospite. Tuttavia, poco si cono...

  9. A New nutritional Approach for promoting Gut Health and Animal Performance

    OpenAIRE

    ULGHERI, CATERINA

    2010-01-01

    Il fattore antisecretivo (AF) è una proteina secreta nel plasma e nei tessuti dei mammiferi, che ha dimostrato di essere un potente inibitore dell’ipersecrezione intestinale e dell'infiammazione. Dopo il bando degli AGP, diversi approcci nutrizionali finalizzati all’ottimizzazione della fase di transizione dello svezzamento e alla riduzione delle malattie intestinali sono stati proposti, ma con scarsi risultati rispetto agli antibiotici. Le diete in grado di indurre la secrezione endogena di ...

  10. Role of gut commensal microbiota regulating colonic sensory-related systems

    OpenAIRE

    Aguilera Pujabet, Mònica

    2014-01-01

    La microbiota comensal del intestino se considera un factor clave en la homeostasis gastrointestinal. Las alteraciones funcionales gastrointestinales (síndrome del intestino irritable, SII) y las enfermedades inflamatorias intestinales (EII) se han relacionado con alteraciones de la microbiota comensal (disbiosis). Estos pacientes muestran una activación inmune local anormal, con respuestas motoras y sensoriales alteradas, que en el SII se traducen en estados de hipersensibili...

  11. Echokardiographie aktuell: Hämodynamische Evaluierung beim Intensivpatienten

    OpenAIRE

    Grausenburger P

    2006-01-01

    bVorgeschichte/bbr Bei einem 47jährigen Mann besteht ein Z. n. Pankreasresektion sowie teilweiser Ileumresektion bei chirurgischer Sanierung einer ausgedehnten abszedierenden Pseudozyste (infolge rezidivierender Pankreatitiden). Seitdem liegt ein intestinales Malabsorptionssyndrom vor, der Patient muß infolgedessen täglich selbst über einen Port-a-cath-Katheter zusätzlich parenterale Ernährung applizieren. Er gelangt hochfiebernd im Bild eines septischen Schocks an der internistischen Inte...

  12. Acarbose als Carbophor

    OpenAIRE

    Merettig, Nadine

    2014-01-01

    Das Pseudotetrasaccharid Acarbose ist seit 1990 als kompetitiver Inhibitor intestinaler α-Glucosidasen (GlucobayTM/PrecoseTM) in der medizinischen Anwendung bei der Therapie von Diabetes mellitus Typ-2. Charakteristisch für die Struktur der Acarbose ist die Acarviosyleinheit, bei der Valinamin und Desoxyglucose N-glycosidisch verknüpft sind; des Weiteren ist an die Acarviosyleinheit ein Maltosylrest gebunden. Der Inhibitoreffekt beruht auf der irreversiblen Bindung zwischen ...

  13. ‘PROBIOTIC BACTERIA ADMINISTRATION AS AN IMMUNOMODULATORY APPROACH FOR FOOD ALLERGY TREATMENT: PRECLINICAL STUDIES IN MOUSE MODELS’

    OpenAIRE

    Schiavi, Elisa

    2013-01-01

    Studi clinici ed epidemiologici hanno messo in evidenza l’associazione tra l’aumentata prevalenza delle malattie allergiche nei Paesi occidentali e la ridotta esposizione ai germi e/o l’ alterazione delle comunità microbiche intestinali, il cui metabolismo e composizione risultano cruciali per lo sviluppo e il mantenimento delle funzioni immunitarie. Riportare all’equilibrio il microbioma intestinale potrebbe rappresentare una strategia preventiva e/o terapeutica per le allergie, in particola...

  14. Antigenpräsentation in der intestinalen Mukosa

    OpenAIRE

    Baumgart, Daniel C.

    2005-01-01

    Die Ätiologie chronisch entzündlicher Darmerkrankungen ist bis heute ungeklärt. Sie beinhaltet eine unkontrollierte Aktivierung von immunologischen Effektorzellen durch antigenpräsentierende Zellen, wie zum Beispiel dendritische Zellen und intestinale Epithelzellen, die Antigene der luminalen Flora fehlerkennen und/oder falsch verarbeiten und den daraus resultierenden Gewebsschädigungsmechanismen. Am Interleukin-2 defizienten Mausmodell der Colitis ulcerosa konnten wir zeigen, daß T-Zellen ...

  15. Rischi connessi al consumo di OGM: un modello animale

    Directory of Open Access Journals (Sweden)

    M. Orsini

    2003-05-01

    Full Text Available

    Obiettivi: materie prime e derivati da organismi geneticamente modificati (OGM sono autorizzati e regolamentati sia per il consumo umano, che per quello animale. Sono stati svolti da alcuni autori lavori che evidenziano la permeabilità della barriera intestinale di mammiferi a molecole di DNA di dimensioni superiori ad 1 kB. Tali molecole (non necessariamente provenienti da OGM una volta attraversata la barriera rimangono nei tessuti, fino alla loro completa degradazione. Non ci sono comunque prove di funzionalità del DNA ingerito e recuperato nei tessuti. Lo scopo è stato quello di valutare la presenza di DNA, in tessuti di pesci di allevamento, nutriti con mangimi a base di soia.

    Metodi: campioni di mangime ed esemplari di pesci sono stati raccolti in alcuni allevamenti del centro Italia. Il contenuto di soia OGM nei mangimi è stato quantificato mediante real time PCR. Frammenti di vari organi sono stati prelevati dagli esemplari e sottoposti ad estrazione di DNA. La presenza di frammenti di geni vegetali e transgeni è stata valutata mediante specifiche reazioni di PCR.

    Risultati: il 90% dei mangimi raccolti è risultato OGM positivo in misura variabile tra lo 0.5% ed il 60%. Sono stati analizzati 75 pesci (spigole e orate provenienti da 5 allevamenti. Non è stata riscontrata presenza di DNA esogeno nei tessuti analizzati tranne deboli segnali positivi nel tessuto intestinale. Questo dato è presumibilmente da imputare alle difficoltà di ottenere preparazioni di DNA intestinale prive di contaminazione alimentare.

    Conclusioni: i risultati ottenuti non rilevano attraversamento della parete intestinale da parte del DNA ingerito. Le motivazioni del disaccordo con i dati di letteratura possono essere ricercate nella scelta del modello ittico, distante dai mammiferi sia in termini filogenetici quanto in modalità alimentari. Il destino del DNA ingerito

  16. Cytotoxic and antibacterial properties of Mytilus galloprovincialis, Ostrea edulis and Crassostrea gigas (bivalve molluscs) hemolymph

    OpenAIRE

    Hubert, Florence; Van Der Knaap, Wil; Noel, Thierry; Roch, Philippe

    1996-01-01

    Le plasma de la moule Mytilus galloprovincialis possède une activité cytotoxique dirigée à la fois contre des cellules de vertébrés (hématies et cellules tumorales de souris) et contre des protozoaires. Les cellules procaryotes (Escherichia coli et Vibrio alginolyticus) ne sont pas sensibles à l'activité cytotoxique. L'activité est toujours présente après dialyse des échantillons mais est inhibée par chauffage à 45°C. L'existence d'une importante variabilité individuelle, non corrélée à la co...

  17. Expression, purification et cristallisation de l'aminopeptidase-N humaine (APN ou CD13) : évaluation in vitro et in vivo d'inhibiteurs sélectifs

    OpenAIRE

    Schmitt, Céline

    2012-01-01

    L'Aminopeptidase-N (APN ou CD13) [EC.3.4.11.2] est une ectoenzyme homodimérique de nature glycoprotéique appartenant à la famille M1 des zinc-aminopeptidases. Elle est surexprimée à la surface des cellules endothéliales angiogéniques, ainsi que sur un certain nombre de cellules tumorales. Et il existe une corrélation étroite entre l'élévation de l'expression de l'APN, une activité enzymatique accrue et le pouvoir invasif de nombreux types de cellules tumorales. Des inhibiteurs puissants et sé...

  18. Imagerie du réseau cellulaire osseux par nano-tomographie synchrotron

    OpenAIRE

    Joita Pacureanu, Alexandra

    2012-01-01

    Les ostéocytes sont les plus nombreuses cellules du tissu osseux, enterrées dans la matrice osseuse. Elles sont interconnectées par des dendrites, situées dans des canaux appelés canalicules. Les lacunes ostéocytaires, les cavités dans lesquelles les cellules sont logées, avec les canalicules forment un réseau de communication à travers la matrice osseuse, permettant le transport des nutriments et des signaux. Ces cellules, considérées d’abord passives, ont révélé dernièrement leur rôle en ta...

  19. Functional analysis of different haematopoietic stem cell subsets

    OpenAIRE

    Chawla R

    2009-01-01

    RÉSUMÉ : Elucider les bases moléculaires et cellulaires du fonctionnement des cellules souches s'avère crucial dans la compréhension de l'organisation cellulaire au sein des tissus et des organes ainsi que pour le développement de nouvelles stratégies thérapeutiques en médecine régénérative et en oncologie. Les cellules souches adultes les mieux connues sont celles responsables de l'hématopoïèse, les cellules souches hématopoïétiques (CSH). Durant ces dernières années, la recherche a porté un...

  20. Phenotypic heterogeneity of antigen-specific CD4 cells under different conditions of antigen persistence and antigen load

    OpenAIRE

    Vallélian F.

    2006-01-01

    RESUME Nous n'avons pas de connaissance précise des facteurs à l'origine de l'hétérogénéité phénotypique des cellules T CD4 mémoires. Une troisième population phénotypique des cellules T CD4 mémoires, caractérisée par les marqueurs CD45RA+CCR7- a été identifiée dans cette étude. Cette population présente un état de différentiation avancée, comme en témoigne son histoire de réplication, ainsi que sa capacité de prolifération homéostatique. Les réponses des cellules T CD4 mémoires à différentes...

  1. Synthèse d'hybrides vinblastine-phomopsine

    OpenAIRE

    Gherbovet, Olga

    2013-01-01

    La tubuline est une protéine essentielle de la cellule. En polymérisant sous forme de microtubules, elle crée notamment le fuseau mitotique le long duquel migrent les chromosomes pendant la mitose. Les médicaments qui inhibent la polymérisation et/ou la dépolymérisation de la tubuline sont des composés majeurs de la thérapie anticancéreuse. Les vinca-alcaloïdes en sont des représentants importants. Ils induisent la mort des cellules par apoptose, en inhibant la dynamique des microtubules. D’a...

  2. Bone scan in diagnosis of infectious osteoarthritis

    International Nuclear Information System (INIS)

    Bone scan with Technetium 99m is harmless method of evaluation of skeletal lesions. It is safe in pediatrics age group and it can be used in early diagnosis of infectious osteoarthritis. Bone scan differentiate osteomyelitis from cellulitis, and also it may help in diagnosis of subclinical involvement of rheumatoid arthritis, benign and malignant bone tumors, stress fractures and periostitis. We report results of bone scan in 30 pediatrics patients as follow: osteomyelitis 9 cases, cellulitis 4 cases, infectious arthritis 7 cases, tuberculous osteoarthritis 2 cases, rheumatoid arthritis 2 cases, and other different diseases 9 cases

  3. Bone scan in diagnosis of infectious osteoarthritis

    International Nuclear Information System (INIS)

    Bone scan with Technetium 99m is harmless method of evaluation of skeletal lesions. It is safe in pediatrics age group and it can be used in early diagnosis of infectious osteo-arthritis. Bone scan differentiate osteomyelitis from cellulitis, and also it may help in diagnosis of subclinical involvement of rheumatoid arthritis, benign and malignant bone tumors, stress fractures and periostitis. We report results of bone scan in 30 pediatric patients as follows: osteomyelitis 9 cases, cellulitis 4 cases, infectious arthritis 4 cases, tuberculous osteoarthritis 2 cases, rheumatoid arthritis 2 cases and other different diseases 9 cases

  4. Diagnosis of osteomyelitis in children by combined blood pool and bone imaging

    International Nuclear Information System (INIS)

    Differentiation of osteomyelitis from cellulitis or septic arthritis can be difficult. The radiological examination often does not have the characteristic features. Seventy of 71 children with osteomyelitis had focal areas of increased radioactivity demonstrated by /sup 99m/Tc methylene diphosphonate bone scans at the site of the infection. The addition of blood pool images aids in the interpretation of the study as they permit evaluation of the effect of hyperemia. The 13 children with cellulitis had diffuse increase in radioactivity involving both the bones and soft tissues. Bone imaging as the initial screening procedure for osteomyelitis is recommended. (auth)

  5. Abréviations

    OpenAIRE

    2013-01-01

    ADEGE Agence nationale pour la démoustication et la gestion des espaces démoustiqués CAREC Caribbean Epidemiology Center CDC Center for Disease Control and Prevention CIRE Cellule interrégionale d'épidémiologie Antilles-Guyane CIRE Cellule interrégionale d'épidémiologie Antilles-Guyane DFA Département français d'Amérique DHF Dengue Hemorrhagic Fever DSDS Direction de la santé et du développement social DSS Dengue shock Syndrome EDEN European Association of Public Operators for Mosquito Contro...

  6. INSULIN INDUCES NITRIC OXIDE PRODUCTION IN BOVINE AORTIC ENDOTHELIAL CELLS

    Institute of Scientific and Technical Information of China (English)

    李慧丽; 黄定九

    2000-01-01

    ffeStun6. ObjeCtif Dens cette dtude nons avons ewilue l' effet de l' insuline sur ba Proliferation cellulaire, liberationd' oxide nitrique et l' expression gdrktique de synthase d' oxide nitrique dens la cellule endotheliale aortique bovine. methIn mitogdthe est evalude per la ndthae M7T. In Production de NO dans ie alga en culture est determine per la reactionGness. In technique quantitative RT/PCR est utility pour quantifier ie niveau de sWthase d' oxide nitrique mRNA dens la cellule endotheliale aortique...

  7. Dispositif de veille au Cemagref

    OpenAIRE

    Taoussi, M.; Giovannini, F; Jannès-Ober, E.

    2007-01-01

    / Dans le cadre de sa mission d'appui à l'animation scientifique et technique et de soutien à la stratégie, le service IST du Cemagref met en place une "cellule d'appui à la veille" ayant pour objectifs de fournir un appui méthodologique et logistique adaptés en fonction de chaque type de veille. Le champ d'action de la cellule s'étend à différents niveaux de veille (veille stratégique, veille pour la prospective et veille scientifique, technologique et sociétale) ; elle utilise divers outils...

  8. Novel Materials for Cellular Nanosensors

    OpenAIRE

    Sasso, Luigi; Svendsen, Winnie Edith; Emnéus, Jenny; Castillo, Jaime

    2012-01-01

    Den overvågning af cellulær adfærd er nyttig til fremskridtet af den biomedicinske diagnostik, lægemiddeludvikling og forståelsen af en celle som hovedenhed af det menneskelige legeme. Mikro- og nanoteknologi giver mulighed for oprettelsen af funktionelle enheder, der forbedrer studiet af cellulære dynamik ved at give platforme, der tilbyder biokompatible overflader til celledyrkning i lab-on-chip enheder integreret med optimerede nanosensorer med høje specificiteter og følsomhed over for cel...

  9. Neurosciences mathématiques

    OpenAIRE

    Touboul, Jonathan

    2014-01-01

    Responsable : Jonathan Touboul Projets scientifiques Le cerveau est un système complexe au sens fort. Il est composé d’un nombre gigantesque de cellules, parmi lesquelles les neurones, qui sont des cellules électriques excitables soumises à un aléa (bruit) intense. Le cerveau forme de grandes aires corticales, telles que les colonnes corticales ou champs neuronaux (spatialement étendus) chargés du traitement d’informations ou de tâches spécifiques. L’analyse mathématique de tels systèmes est ...

  10. Orbital abscess secondary to acute dacryocystitis: case report Abscesso orbitário secundário à dacriocistite aguda: relato de caso

    OpenAIRE

    Marcia Clivati Martins; José Reinaldo da Silva Ricardo; Patrícia Mitiko Santello Akaishi; Antonio Augusto Velasco e Cruz

    2008-01-01

    Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao co...

  11. Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin.

    Science.gov (United States)

    Kačániová, Miroslava; Vukovič, Nenad; Horská, Elena; Salamon, Ivan; Bobková, Alica; Hleba, Lukáš; Fiskelová, Martina; Vatľák, Alexander; Petrová, Jana; Bobko, Marek

    2014-01-01

    In the present study, the antimicrobial and antiradical activities of 15 essential oils were investigated. The antimicrobial activities were determined by using agar disc diffusion and broth microdilution methods against Clostridium genus and antioxidant properties of essential oils by testing their scavenging effect on DPPH radicals activities. We determined the antibacterial activity of Clostridium butyricum, Clostridium hystoliticum, Clostridium intestinale, Clostridium perfringens and Clostridium ramosum. We obtained the original commercial essential oils samples of Lavandula angustifolia, Carum carvi, Pinus montana, Mentha piperita, Foeniculum vulgare Mill., Pinus sylvestris, Satureia montana, Origanum vulgare L. (2 samples), Pimpinella anisum, Rosmarinus officinalis L., Salvia officinalis L., Abies alba Mill., Chamomilla recutita L. Rausch and Thymus vulgaris L. produced in Slovakia (Calendula a.s., Nova Lubovna, Slovakia). The results of the disk diffusion method showed very high essential oils activity against all tested strains of microorganisms. The best antimicrobial activity against C. butyricum was found at Pimpinella anisum, against C. hystoliticum was found at Pinus sylvestris, against C. intestinale was found at Satureia hortensis L., against C. perfringens was found at Origanum vulgare L. and against C. ramosum was found at Pinus sylvestris. The results of broth microdilution assay showed that none of the essential oils was active against C. hystoliticum. The best antimicrobial activity against C. butyricum was found at Abies alba Mill., against C. intestinale was found at Abies alba Mill., against C. perfringens was found at Satureia montana and against C. ramosum was found at Abius alba and Carum carvi. Antioxidant DPPH radical scavenging activity was determined at several solutions of oil samples (50 μL.mL(-1)-0.39 μL.mL(-1)) and the best scavenging effect for the highest concentration (50 μL.mL(-1)) was observed. The antioxidant properties

  12. Relación “Saneamiento Básico y Prevalencia de Entero parásitos” en estudiantes del Colegio German Busch, La Paz - 2013

    Directory of Open Access Journals (Sweden)

    Leandro Ribeiro França

    2013-12-01

    Full Text Available Las infecciones parasitarias intestinales son enfermedades que afectan a una gran parte de la población infantil en los países más subdesarrollados y en vías de desarrollo y en muchos casos se convierte en una causa de muerte. El objetivo de este estudio fue establecer un paralelo entre las condiciones sanitarias aportadas por la Comunidad Minera Bolsa Negra - La Paz - Bolivia y la presencia de enteroparasitos en niños entre 07 y 12 años de la referida comunidad. Se aplicó en este proyecto un método de estudio observacional descriptivo, a través del estudio de casos y controles. En cuanto a los resultados, mediante el análisis de materia fecal de los niños parte del universo de la investigación, donde encontró diferentes formas evolutivas de parásitos intestinales, con 100% de prevalencia para los géneros Blastocystis hominis , Giardia lamblia y Entamoeba coli. También se analizó el grado de conocimiento por parte de las madres de los niños que participaron en la investigación que indica un mal conocimiento general en lo que respecta a servicios de saneamiento básico y la higiene personal. También se presentaron las formas y medidas para la prevención de enfermedades relacionadas con los parásitos intestinales encontrados.

  13. Identificación de Parásitos Gastrointestinales en dos Especies de Delfines en Cautiverio del Acuario y Museo del Mar el Rodadero ubicado en Santa Marta‚ Magdalena -resumen-

    OpenAIRE

    Dave Wehdeking-Hernández; Rodríguez, J.; C Zuluaga; Luis Barrios; Julio Mejía

    2014-01-01

    Las infecciones parasitarias en animales tienen distribución mundial y se caracterizan por una sintomatología intestinal inespecífica; por procesos clínicos que pueden ser agudos‚ sub agudos y crónicos. La epidemiologia de las parasitosis intestinales es muy variada‚ depende del tipo de parásito‚ del área geográfica‚ del estado general del hospedero y de los hábitos poblacionales. Teniendo en cuenta que los delfines son uno de los principales atractivos del acuario‚ se estableció un protocolo...

  14. Ingestión accidental de prótesis dental fija (cantilever) en paciente con historia de carcinoma de colon Accidental swallowing of fixed denture (cantilever) in a patient with history of colon cancer

    OpenAIRE

    G.M. Fonseca

    2011-01-01

    Se presenta un caso de ingestión accidental de un puente de tipo cantilever metalocerámico de tres unidades en un paciente masculino de 51 años con historia de remoción quirúrgica de carcinoma colorrectal y colostomía provisoria (ano contranatura) para recuperación intestinal cuatro años antes. Aun cuando la naturaleza del objeto ingerido y las condiciones patológicas previas intestinales ponderan una conducta quirúrgica de remoción preventiva, dado el carácter asintomático y el control radio...

  15. Evaluaciones toxicol??gicas de un extracto acuoso del alga marina Bryothamnion triquetrum (Gmelin) M.A.Howe en estudios in vitro y modelos animales

    OpenAIRE

    A Vidal-Novoa; Fallarero-Linares, A.; Laba??ino, M.; S??nchez-Lamar, A.; Batista-Gonz??lez, A.E.; Silva, Amo; Mancini-Filho, J.

    2012-01-01

    Objetivo: El objetivo de este trabajo fue evaluar la toxicidad de un extracto acuoso del alga marina Bryothamnion triquetrum. M??todos: El ensayo de Ames se desarroll?? con las cepas de S. typhimurium TA 1535, TA 1537 y TA 1538 con y sin activaci??n metab??lica. El estudio de citotoxicidad se realiz?? con c??lulas intestinales Caco-2 durante 24 y 48 horas de exposici??n al extracto y la viabilidad fue evaluada con la t??cnica de yoduro de propidio. El Estudio de Toxicidad Aguda se realiz??...

  16. Le syndrome d'ogilvie post césarienne: une complication mystérieuse: à propos d'un cas

    OpenAIRE

    Amourak, Sarah; Tayae, Mariam; Jayi, Sofia; Alaoui, Fatimazahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    Le syndrome d'ogilvie ou appeler encore Pseudo-occlusion colique aiguë (acute colonic pseudo-obstruction), décrit par Sir William Ogilvie en 1948 et correspond à une dilatation aiguë du colon antérieurement sain, survenant en l'absence d'obstruction mécanique avec un diamètre cæcal > 9 cm, La symptomatologie correspond à celle d'une occlusion intestinale basse, d'installation rapide et l'imagerie fait d'ASP et de TDM abdominale permet de mettre en évidence la distension cæcale dont la mesure ...

  17. Potencialidad probiótica de lactobacilos con capa S : Estudios sobre la inocuidad, efecto antimicrobiano y capacidad inmunomodulatoria de Lactobacillus kefiri

    OpenAIRE

    Carasi, Paula

    2014-01-01

    El tracto gastrointestinal de los mamíferos contiene una gran cantidad de microorganismos, microbiota, con los que se establece una relación simbiótica. Los desbalances de la misma, disbiosis, tienen consecuencias nocivas para el huésped y puede contribuir al desarrollo de enfermedades inflamatorias intestinales. El uso de microorganismos probióticos es una de las estrategias que se encuentran en desarrollo para intentar restaurarla o fortalecerla. El Kefir es un alimento descripto por el...

  18. Prevalencia de parasitosis intestinal en mujeres embarazadas del Centro de Salud Jaihuayco Julio-Septiembre 2012

    OpenAIRE

    Ana Gilca Santander Lopez; Veronica Quicaña Andaluz; Elias Lessin Garcia Alba; Sergio Torrico Condarco; Naida Bernal Hinojosa

    2013-01-01

    Las parasitosis intestinales afectan de manera especial a poblaciones con bajos recursos económicos, con una alta prevalencia en países en vías de desarrollo, probablemente debido a la falta educación (higiene o de manipulación de alimentos), poca accesibilidad a recursos básicos (agua potable, alcantarillado, etc.) y la pobreza. Los extremosde vida como niños y ancianos, al igual que las mujeres embarazadas son grupos poblacionales vulnerables a las parasitosis, siendo importante la repercus...

  19. Développement de Borrelia burgdorferi dans la tique Ixodes ricinus

    OpenAIRE

    Gern, Lise; Z. Zhu; Aeschlimann, André

    2011-01-01

    Nous avons étudié le développement de Borrelia burgdorferi dans son vecteur européen, la tique Ixodes ricinus, lors du repas sanguin. Nos résultats montrent que durant la phase de gorgement lente, les spirochètes présents dans l'intestin se multiplient. Chez certains individus, quelques spirochètes traversent la paroi intestinale et produisent une infection systémique de la tique. La présence de borrélies dans les conduits des glandes salivaires semblent prouver leur transmission via la saliv...

  20. Úlceras Colónicas por TB e Histoplasmosis en un paciente portador de VIH/Sida

    Directory of Open Access Journals (Sweden)

    Rafael Garzona-Schmidt

    2001-07-01

    Full Text Available Se describe un paciente masculino de 35 años, costarricense, con un cuadro de trastornos intestinales inespecíficos, de 3 años de evolución, intensificados en el último mes previo a su internamiento, siendo diagnosticado con VIH y mediante colonoscopía se le diagnosticó una enfermedad inflamatoria colónica por tuberculosis e histoplasmosis intestinal, la cual resolvió en su totalidad luego de nueve meses de tratamiento antifímico y antifungico.

  1. Un estudio empírico sobre factores sociales y enfermedad de Crohn desde la perspectiva de la psicología social de la salud

    OpenAIRE

    Dios Duarte, María José de

    2010-01-01

    Una de las realidades constatadas y que nos ha llevado al presente estudio, fue el llegar a descubrir que había muy poca documentación, desde el punto de vista de la psicología social, sobre las variables psicosociales y su influencia en los enfermos de Crohn. Las investigaciones realizadas hasta ahora en esta línea han estado siempre orientadas al estudio de las enfermedades inflamatorias intestinales y no exclusivamente a la enfermedad de Crohn. Por todo ello, en la siguiente investigación,...

  2. Intestinal anastomosis wound healing after platelet-rich plasma (PRP) application on pigs. Macroscopic, microscopic and breaking strength evaluations

    OpenAIRE

    Rafael Bambo, Otilia

    2009-01-01

    La enterectomía es un procedimiento quirúrgico que consiste en suturar dos segmentos intestinales, la mayor complicación que aparece es la pérdida por las suturas y las dehiscencias y que están asociadas a una alta morbilidad y mortalidad. En pequeños animales las complicaciones en las anastomosis del intestino delgado tienen una incidencia 7-16%, y cerca 74-80% de estos pacientes mueren. Se han realizado diversos procedimientos para asegurar la impermeabilidad de la anastomoses: Omentoplast...

  3. Fármacos que inhiben el factor de necrosis tumoral α y embarazo

    OpenAIRE

    Cristian Simon, Petru; Vallano Ferraz, Antonio

    2013-01-01

    Pregunta: ?Es segura la administración de los fármacos que inhiben el factor de necrosis tumoral a (TNF-a) durante el embarazo? Respuesta: En los últimos años se han desarrollado medicamentos que inhiben el TNF-a, porque esta citocina tiene un efecto inflamatorio que condiciona el proceso patológico de diversas enfermedades autoinmunitarias sistémicas, como artritis reumatoide, psoriasis, enfermedades inflamatorias intestinales y otras. Actualmente existen en el mercado farmacéutico 5 fármaco...

  4. Prevalencia de huevos de helmintos en lodos, agua residual cruda y tratada, provenientes de un sistema de tratamiento de aguas residuales del municipio El Rosal, Cundinamarca / Prevalence of Helminthes eggs in treated and un-treated waste water and sewage from the Rosal sewage treatment plant in Cundinamarca

    OpenAIRE

    Ortiz Pineda, Carolina

    2010-01-01

    El uso de aguas residuales para la irrigación de cosechas es una práctica común en el mundo; esta actividad provee importantes beneficios tanto al suelo como a la productividad agrícola. Sin embargo representa un importante riesgo para la salud pública como resultado de la potencial dispersión de infecciones parasitarias. La prevalencia de infecciones intestinales parasitarias en Colombia obtenida de una muestra probabilística de la población fue de 81.8% (1980), pero la fuente de contaminaci...

  5. Actualización en fibromialgia

    OpenAIRE

    Danny Chavez Hidalgo

    2013-01-01

    El síndrome de fibromialgia (FM) es una enfermedad crónica que causa dolor, rigidez y sensibilidad en músculos, tendones y articulaciones. También se caracteriza por alteraciones del sueño, cansancio, fatiga, ansiedad, depresión y alteraciones en las funciones intestinales. La etiología de la fibromialgia sigue siendo desconocida, pero los recientes avances y descubrimientos han ayudado a desentrañar algunos de los misterios de esta enfermedad. La investigación pone de relieve algunas de las ...

  6. Presentación de un caso clínico de pleuresia por amiba histológica

    OpenAIRE

    Olaya Restrepo, Max

    2011-01-01

    (Leido en lo Segundo Convención Anual de la Asociación Nacional de GastroEnterología)Parece probable que el caso que aquí se presenta es el primero en la literatura Médica Nacional, en el cual se ha encontrado la Endamoeba Histolítica" en un órgano que no se considera frecuente entre las localizaciones extra-intestinales de este parásito. En efecto, en la breve revisión que se ha hecho de la bibliografía, se encuentran publicadas varias localizaciones en la piel, una en la vagina, las rarísim...

  7. Galacto-oligosacáridos derivados de lactulosa multifuncionales con actividad inmunomoduladora y prebiótica

    OpenAIRE

    Clemente, Alfonso; Rubio, Luis A.; Sanz, Yolanda; Laparra, José Moisés; Sanz, Maria Luz; Hernández-Hernández, O.; Montilla, Antonia; Olano, Agustín; Moreno, F. Javier

    2011-01-01

    La presente invención reivindica el carácter multifuncional de unos galactooligosacáridos derivados de la lactulosa (GOS-Lactulosa) empleando modelos in vivo (ratas Wistar) e in vitro utilizando líneas celulares intestinales de origen humano (Caco- 2 y HT29-MTX) validadas como modelo de epitelio intestinal. Las ventajas principales derivadas del uso de este producto son múltiples y de gran valor añadido: propiedades prebióticas mejoradas y adicionales a las de los p...

  8. Influencia de distintos glúcidos y lípidos en la dieta sobre aspectos del metabolismo lipídico en la rata

    OpenAIRE

    López Jiménez, José Ángel

    1994-01-01

    Cuando se utilizan dietas isocalóricas, la modificación del tipo de grasa o el tipo de azúcar, no influye sobre el crecimiento, ni la ingesta, incluso cuando los glúcidos simples alcanzan valores del 30%. Solo en el caso de que el glúcido sea sacarosa se produce una disminución de la ingesta y del crecimiento, poniéndose de manifiesto un efecto negativo no solo a nivel metabólico, sino también del apetito, posiblemente a través de receptores intestinales, la existencia de una secuencia de … [...

  9. Parasitismo intestinal e intensidad de las helmintiasis adquiridas del suelo en dos comunidades de la costa norte colombiana

    OpenAIRE

    García Laverde, Alberto; Jimenez, Cecilia; Giraldo Morales, Ofelia

    2011-01-01

    Una encuesta basada en el examen cualitativo y cuantitativo de una sola muestra de materias fecales de 247 indígenas de la Guajira, demostró parásitos intestinales en el 93 por ciento de las personas estudiadas. La prevalencia de E. bistolytica fue del 61 por ciento, y las cifras para las otras especies de amibas fue igualmente alta, lo cual viene a confirmar que estos indígenas viven en condiciones ambientales y de higiene personal que favorecen ampliamente la transmisión de ciertos parásito...

  10. Incidencia de estreñimiento en una unidad de hemodiálisis Incidence of constipation in a haemodialysis unit

    OpenAIRE

    Antonia Gil Gil; Ana Gumbao Valero; Ana Belén Canales Vitoria

    2006-01-01

    Los pacientes en programa de hemodiálisis pueden padecer con frecuencia problemas y enfermedades intestinales por lo que hemos decidido abordar un problema tan importante como el estreñimiento. Estos pacientes tienen numerosos factores de riesgo para padecer esta enfermedad, como son restricciones en la ingesta de frutas, verduras, líquidos y otros alimentos, además de tomar medicación astringente por lo que hemos querido conocer cómo influyen estos factores y cuál era el porcentaje de estos ...

  11. Evaluación de la calidad microbiológica de los microorganismos probióticos en productos lácteos fermentados comerciales en la ciudad de Ocotlán, Jalisco

    OpenAIRE

    Guerrero Medina, Pedro Javier

    2012-01-01

    Las bacterias ácido-lácticas (BAL) están asociadas con los alimentos y la salud, son objeto de estudio de investigación biotecnológica. En la microbiota intestinal encontramos a los probióticos con una potencial aplicación en la prevención de las infecciones intestinales. La FAO/OMS, los definen como ¿microorganismos vivos que cuando son administrados en cantidades adecuadas confieren un beneficio a la salud del huésped¿. En la actualidad el consumo de alimentos con probióticos se está incre...

  12. Estudio de las alteraciones del esmalte en la enfermedad celiaca

    OpenAIRE

    Bonet Coloma, Cristina

    2013-01-01

    La enfermedad celiaca (EC) es una enteropatía caracterizada por una intolerancia permanente al gluten, proteína existente en el trigo, centeno, cebada y avena que provoca una lesión severa de las vellosidades intestinales, y se normaliza tras su retirada de la dieta. La sintomatología varía de un paciente a otro dependiendo del daño de la mucosa intestinal. La presentación típica incluye diarrea, pérdida de peso, fatiga, distensión abdominal, vómitos, deficiencias nutricionales y anemia p...

  13. Terapia nutricia en fístula enterocutánea; de la base fisiológica al tratamiento individualizado

    OpenAIRE

    Ameyalli Mariana Rodríguez Cano

    2014-01-01

    La fístula enterocutánea es la forma más común de las fístulas intestinales. Es una patología que obliga la estancia hospitalaria prolongada debido a complicaciones como desequilibrio hidroelectrolítico, desnutrición, desajustes metabólicos y sepsis. El apoyo nutricio es parte esencial en el manejo, ya que favorece la función intestinal, inmune, promueve la cicatrización y disminuye el catabolismo. Aunque se ha reconocido la importancia del apoyo nutricio no existen ensayos clínicos sobre su ...

  14. Contextualización de la Espina Bífida en Cádiz: Análisis y propuesta de intervención. Un enfoque familiar

    OpenAIRE

    Domínguez González, Lorena María

    2015-01-01

    La Espina Bífida es una patología congénita, la cual básicamente consiste en un defecto del cierre del tubo neural del feto al no fusionarse los arcos vertebrales posteriores, con el consiguiente riesgo de producir daños en la médula espinal y el sistema nervioso. Afecta a un bajo porcentaje de la población (aproximadamente 0,45 de cada 1000 nacidos), causándoles principalmente alteraciones neurológicas, motoras, intestinales y urinarias. La Espina bífida conlleva una disminución impo...

  15. Indicadores bacteriológicos de contaminación fecal en la Bahía de la Habana

    OpenAIRE

    Lisse López Pérez; Yamiris Gómez D´Angelo; Jesús Beltrán González; Reinaldo Álvarez Valiente

    2013-01-01

    Objetivos. Cuantifi car los indicadores bacteriológicos de contaminación fecal en la Bahía deLa Habana. Metodología. En muestreos realizados desde abril/2010 hasta febrero/2011, mediantemétodos de fermentación en tubos múltiples (NMP), se determinaron las concentraciones de coliformestermotolerantes (CTT), Escherichia coli, estreptococos fecales (EF), enterococos intestinales (ENT)en agua, y Clostridium perfringens en los sedimentos superfi ciales. Resultados. Las concentracionesde CTT y E. c...

  16. Contenido de alimento y metabolismo ceco-cólico en el tracto digestivo de poblaciones silvestres de iguana negra (Ctenosaura pectinata) en Morelos, México Cecum-colic content of food and metabolism in the digestive tract of wild population black lizard (Ctenosaura pectinata) in Morelos, Mexico

    OpenAIRE

    L Vélez-Hernández; MA Cobos-Peralta; JL Arcos-García

    2012-01-01

    Se colectaron cinco tractos digestivos de iguana negra (Ctenosaura pectinata) en estado silvestre en el estado de Morelos, México, para conocer la composición botánica de la dieta y el metabolismo ceco-cólico. Se observaron frotis realizados del contenido ceco-cólico para registrar la presencia de protozoarios, bacterias y parásitos intestinales existentes. Se obtuvo la media y desviación estándar de las características evaluadas. En el contenido ceco-cólico se identificaron las especies vege...

  17. Atresia duodenal asociada a invaginación intestinal secundaria a divertículo de meckel en un lactante de tres meses

    OpenAIRE

    Rubén Martín Alvarez-Solís; Fredy Chablé-Montero; Marcela Vargas-Vallejo; David Bulnes Mendizábal; Armando Quero-Hernández; José Cabrera-Aguirre

    2006-01-01

    La asociación entre atresia duodenal e invaginación intestinal no se ha reportado en la literatura. Presentamos las características clínicas y quirúrgicas de un paciente masculino de tres meses de edad que presenta atresia duodenal asociada a invaginación intestinal secundaria a un divertículo de Meckel perforado e invertido. Dentro de las causas de vómitos en lactantes se incluyen las atresias intestinales. Aunque es raro se han reportado casos en otras edades pediátricas. La invaginación in...

  18. Lesiones remotas ocasionadas por el síndrome isquemia-reperfusión en equinos, fisiopatología y alternativas terapéuticas

    OpenAIRE

    Piedad Cristina Rivas López; Wilson Roberto Mantilla Olivella

    2009-01-01

    Las lesiones del síndrome isquemia y reperfusión  (I/R) en los diferentes cuadros fisiopatológicos de situaciones clínicas, así como también en procedimientos quirúrgicos de alta manipulación vascular y tisular, son de gran importancia en la medicina equina, por ello, la mayoría de estudios se han centrado en este tema, pues sus particularidades de especie aumentan la frecuencia de presentación de accidentes intestinales (White et ál., 1980; Moore et ál., 1995; Faleiros, 1997; Kooreman et ál....

  19. Procesamiento y unión de la toxina Cry11Bb del Bacillus thuringiensis subsp. Medellín al intestino de larvas de mosquitos

    OpenAIRE

    Fanny Guzmán; Adang, Michael J.; Lina Ruiz; César Segura; Sergio Orduz; Manuel Elkín Patarroyo

    2001-01-01

    La proteína Cry11Bb (94 kDa) es producida por B. thuringiensis subsp. Medellín. El modo de acción de las toxinas Cry incluye el procesamiento proteol��tico y la unión de la toxina a receptores específicos sobre la superficie del intestino de las larvas de los
    insectos susceptibles. Después de unida, la toxina forma poros de baja selectividad sobre la superficie de la membrana apical de las células intestinales, produciendo un desequilibrio osmótico que lleva a la destrucción celula...

  20. Efecto de la inclusión de un hidrolizado de mucosa digestiva porcina (palbio 50 rd®) en piensos de broilers con niveles diferentes de lisina

    OpenAIRE

    Mohiti-Asli, M.; Frikha, M.; Jabbour, C.; Borda, E; Camara, L; Gonzalez Mateos, Gonzalo

    2011-01-01

    La alimentación del pollo broiler durante la primera semana de vida es de creciente importancia debido a que la edad de sacrificio ha disminuido de forma constante en los últimos años. Además, consumos elevados durante la primera semana de vida mejoran el desarrollo del aparato digestivo de las aves, favoreciendo el crecimiento de las vellosidades intestinales y la eficiencia alimenticia (Lilburn, 1998, Noy et al., 2005). En los últimos años, el mercado dispone de nuevos productos de o...

  1. LES SYSTEMES A CONCENTRATION DANS LA CONVERSION PHOTOVOLTAIQUE : BILAN ET PERSPECTIVES

    OpenAIRE

    Laurent, Bernard

    1982-01-01

    SITUATION DE LA PLACE DE LA CONCENTRATION DANS LE DOMAINE DE LA RECHERCHE ACTUELLE EN CONVERSION PHOTOVOLTAIQUE. ANALYSE DE DEUX EXPERIMENTATIONS DE SYSTEMES A CONCENTRATION PAR LENTILLES DE FRESNEL: SOPHOCLE 100 W ET SOPHOCLE 500 W. COMPARAISON AVEC LES PANNEAUX DE CELLULES SOUS CONCENTRATION PERMETTANT DE DEGAGER LES PERSPECTIVES DE DEVELOPPEMENT DU SYSTEME SOPHOCLE Indisponible

  2. Disseminated soft tissue infection and sepsis with Stenotrophomonas maltophilia in a bone marrow transplant patient

    OpenAIRE

    Lipton, Jeffrey H.; MacDonald, Kelly S.

    1996-01-01

    A 32-year-old female presented with aplastic anemia and subsequently underwent a one-antigen mismatched bone marrow transplant from her brother. She failed to engraft and a second graft was attempted. Protracted neutropenia of three months’ duration despite the use of broad spectrum antibiotics occurred. Stenotrophomonas (Xanthomonas) maltophilia metastatic cellulitis developed that did not respond to appropriate antibiotics.

  3. Quando il movimento è malato: la sclerosi laterale amiotrofica

    Directory of Open Access Journals (Sweden)

    Lucio Tremolizzo

    2011-09-01

    Full Text Available La sclerosi laterale amiotrofica (SLA è una malattia neurodegenerativa descritta dal celeberrimo neurologo francese Jean - Martin Charcot (Parigi 1825 - Nièvre 1893 sul finire del 1800. Il quadro è caratterizzato dal coinvolgimento selettivo del primo e del secondo motoneurone, le cellule che, convergendo sul muscolo (l’effettore finale, sono deputate all’espressione del movimento.

  4. Approccio genomico e funzionale allo studio delle alterazioni dei microRNA nelle MPN.

    OpenAIRE

    L. Tozzi

    2012-01-01

    Alterazioni dell'espressione dei microRNA sono state descritte in numerosi tumori sia solidi che ematologici. In questo studio sono stati utilizzati dati funzionali e dati derivanti dalle più recenti tecnologie di analisi genomica high-throughput per identificare subset di microRNA alterati nelle cellule neoplastiche e caratterizzare il loro possibile ruolo.

  5. Un Infrequente caso di "spindle cell tumor" a localizzazione splenica primaria in un cane: rilievi citologici ed istopatologici, osservazioni istochimiche ed immunoistochimiche

    OpenAIRE

    Antuofermo, Elisabetta; Pirino, Salvatore; Rocca, Stefano; Mura, Antonica; Anfossi, Antonio; Zucca, Rosalba; Nieddu, Antonio Mario S.

    2004-01-01

    Tutti i tumori fusocellulari derivano verosimilmente da una unica cellula staminale mesenchimale pluripotente. Macroscopicamente e microscopicamente i tumori delle cellule muscolari lisce e i tumori del tessuto connettivo fibroso, si presentano morfologicamente simili. Abbiamo ritenuto interessante riferire su un cane meticcio, maschio, di quattro anni sottoposto ad eutanasia dopo aver mostrato letargia, anoressia e perdita di peso. Alla necroscopia si osservava ...

  6. Clostridium Perfringens Infection in a Febrile Patient with Severe Hemolytic Anemia

    OpenAIRE

    Hashiba, Masamitsu; Tomino, Atsutoshi; Takenaka, Nobuyoshi; Hattori, Tomonori; Kano, Hideki; Tsuda, Masanobu; Takeyama, Naoshi

    2016-01-01

    Patient: Male, 82 Final Diagnosis: Clostridium perfringens infection Symptoms: Anemia • fever • shock Medication: — Clinical Procedure: Antimicrobial chemotherapy Specialty: Infectious Diseases Objective: Rare disease Background: Clostridium perfringens (C. perfringens) can cause various infections, including gas gangrene, crepitant cellulitis, and fasciitis. While C. perfringens sepsis is uncommon, it is often rapidly fatal because the alpha toxin of this bacterium induces massive intravascu...

  7. Increased Serum Levels of Epidermal Growth Factor in Children with Autism

    Science.gov (United States)

    Iseri, Elvan; Guney, Esra; Ceylan, Mehmet F.; Yucel, Aysegul; Aral, Arzu; Bodur, Sahin; Sener, Sahnur

    2011-01-01

    The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral…

  8. Roseomonas gilardii Infection: Case Report and Review

    OpenAIRE

    Shokar, Navkiran K.; Shokar, Gurjeet S; Islam, Jamal; Cass, Alvah R

    2002-01-01

    Roseomonas gilardii is a bacterium that has been indicated as a rare cause of human infections. The case of a patient presenting with cellulitis and bacteremia secondary to R. gilardii is described together with the clinical characteristics of infection with this organism obtained from a review of cases previously reported.

  9. Bacteremia Caused by Group G Streptococci, Taiwan

    OpenAIRE

    Liao, Chun-Hsing; Liu, Liang-Chun; Huang, Yu-Tsung; Teng, Lee-Jeng; Hsueh, Po-Ren

    2008-01-01

    A retrospective observational study in Taiwan, 1998–2004, identified 92 patients with group G streptococcal bacteremia; 86 had Streptococcus dysgalactiae subspecies equisimilis. The most common diagnosis was cellulitis (48 cases), followed by primary bacteremia (34 cases). Infection recurred in 9 patients. Mortality rate was low (3.3%); resistance to quinupristin-dalfopristin was high.

  10. Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer

    NARCIS (Netherlands)

    Brisset, Jean-Christophe; Hoff, Benjamin A.; Chenevert, Thomas L.; Jacobson, Jon A.; Boes, Jennifer L.; Galban, Stefanie; Rehemtulla, Alnawaz; Johnson, Timothy D.; Pienta, Kenneth J.; Galban, Craig J.; Meyer, Charles R.; Schakel, Timothy; Nicolay, Klaas; Alva, Ajjai S.; Hussain, Maha; Ross, Brian D.; Schakel, Tim

    2015-01-01

    Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellul

  11. Cultural Diagnosis: An Empirical Investigation of Cellular Industry of Pakistan

    OpenAIRE

    Qamar Ali; Manqoosh ur Rehman

    2011-01-01

    This study describes research in five cellular companies operating in Pakistan, aimed at identifying their current and preferred organizational culture. Using Quinn and Rohrbaugh (1983) competing values framework, the overall cultural profiles and dominant characteristics of the organizations and industry are determined through a personally administered survey employing the Organizational Culture Assessment Instrument (OCAI). The results indicate that hierarchy culture is dominating in cellul...

  12. Applicability of deterministic propagation models for mobile operators

    NARCIS (Netherlands)

    Mantel, O.C.; Oostveen, J.C.; Popova, M.P.

    2007-01-01

    Deterministic propagation models based on ray tracing or ray launching are widely studied in the scientific literature, because of their high accuracy. Also many commercial propagation modelling tools include ray-based models. In spite of this, they are hardly used in commercial operations by cellul

  13. Linezolid and Rasagiline - A culprit for serotonin syndrome.

    Science.gov (United States)

    Hisham, Mohamed; Sivakumar, Mundalipalayam N; Nandakumar, V; Lakshmikanthcharan, S

    2016-01-01

    A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline. PMID:26997732

  14. Linezolid and Rasagiline – A culprit for serotonin syndrome

    Science.gov (United States)

    Hisham, Mohamed; Sivakumar, Mundalipalayam N.; Nandakumar, V.; Lakshmikanthcharan, S.

    2016-01-01

    A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline. PMID:26997732

  15. Linezolid and Rasagiline - A culprit for serotonin syndrome

    Directory of Open Access Journals (Sweden)

    Mohamed Hisham

    2016-01-01

    Full Text Available A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline.

  16. Linezolid and Rasagiline - A culprit for serotonin syndrome

    OpenAIRE

    Mohamed Hisham; Sivakumar, Mundalipalayam N.; V Nandakumar; Lakshmikanthcharan, S.

    2016-01-01

    A 65-year-old female patient was admitted to the hospital for cellulitis. She had a history of diabetes mellitus and parkinsonism on levodopa/carbidopa, rasagiline, ropinirole, trihexyphenidyl, amantadine, metformin, and glipizide. We present here a case of rare incidence of serotonin syndrome associated with linezolid and rasagiline.

  17. A biocompatible micro cell culture chamber for culturing and on-line monitoring of Eukaryotic cells

    DEFF Research Database (Denmark)

    Stangegaard, Michael

    2006-01-01

    Visualisering af cellulære processer over længere tidsperioder har været besværliggjort af cellernes krav til varme, fugtighed og et fysiologisk pH balanceret medie. Fremskridt indenfor mikro teknologi har muliggjort fabrikation af miniaturiserede celle kultur anordninger der er i stand til at ho...

  18. Acute lymphangitis in a preschool child: A case report

    Directory of Open Access Journals (Sweden)

    Loh Huai Seng

    2012-12-01

    Full Text Available A 3-year old preschool boy presented with apruritic red streak at the dorsum of his right foot travelingupward from the affected site which was red and swollen.Insect sting was the more likely trigger which had causedthe cellulitis and subsequently the acute lymphangitis.

  19. Gunshot-like wound caused by sling shot injury – a case report

    Directory of Open Access Journals (Sweden)

    Vinuthinee N

    2015-02-01

    Full Text Available Naidu Vinuthinee,1,2 Anuar Azreen-Redzal,1 Jaafar Juanarita,1 Embong Zunaina2 1Department of Ophthalmology, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia; 2Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia Abstract: We report a rare case of sling shot injury that presented with a gunshot-like wound with preseptal cellulitis, in a toddler. An 11-month-old Malay child presented with a gunshot-like wound over the forehead following sling shot injury. On examination, he had a deep circular laceration wound over the forehead, measuring 2.0 cm in diameter, with minimal bleeding. There was no obvious foreign body seen inside the wound and no palpable foreign body surrounding the wound. The gunshot-like wound was associated with left preseptal cellulitis. A skull X-ray showed a white opaque foreign body in the left frontal bone. Computed tomography (CT scan of orbit and brain revealed a left comminuted fracture of the left orbital roof, and left frontal brain contusion with prelesional edema. Wound exploration was performed and revealed a 0.5 cm unshattered marble embedded in the left frontal bone. The marble and bone fragments were removed. The left preseptal cellulitis responded well to intravenous antibiotic and topical antibiotic. Keywords: preseptal cellulitis, orbital roof fracture, pediatric trauma

  20. Mycobacterium fortuitum Infection following Reconstructive Breast Surgery: Differentiation from Classically Described Red Breast Syndrome

    Directory of Open Access Journals (Sweden)

    Orlando J. Cicilioni, Jr, MD, FACS

    2013-10-01

    Conclusions: When presented with possible RBS, surgeons must rule out cellulitis, culture for acid-fast bacilli such as mycobacterium species, and then determine the best course of treatment. Patient counseling regarding potential household sources of infection is warranted to minimize postoperative infection risk.

  1. Feedlot therapeutics.

    Science.gov (United States)

    Apley, M D; Fajt, V R

    1998-07-01

    This article discusses therapeutic approaches to conditions commonly encountered in feedlots. Challenges discussed include bovine respiratory complex, tracheal edema, atypical interstitial pneumonia, footrot, toe abscesses, mycoplasma arthritis, cardiovascular disease, lactic acidosis, bloat, coccidiosis, central nervous system diseases, abscesses and cellulitis, pregnancy management and abortion, and ocular disease. PMID:9704416

  2. Caracterisation thermique de modules de refroidissement pour la photovoltaique concentree

    Science.gov (United States)

    Collin, Louis-Michel

    Pour rentabiliser la technologie des cellules solaires, une reduction du cout d'exploitation et de fabrication est necessaire. L'utilisation de materiaux photovoltaiques a un impact appreciable sur le prix final par quantite d'energie produite. Une technologie en developpement consiste a concentrer la lumiere sur les cellules solaires afin de reduire cette quantite de materiaux. Or, concentrer la lumiere augmente la temperature de la cellule et diminue ainsi son efficacite. Il faut donc assurer a la cellule un refroidissement efficace. La charge thermique a evacuer de la cellule passe au travers du recepteur, soit la composante soutenant physiquement la cellule. Le recepteur transmet le flux thermique de la cellule a un systeme de refroidissement. L'ensemble recepteur-systeme de refroidissement se nomme module de refroidissement. Habituellement, la surface du recepteur est plus grande que celle de la cellule. La chaleur se propage donc lateralement dans le recepteur au fur et a mesure qu'elle traverse le recepteur. Une telle propagation de la chaleur fournit une plus grande surface effective, reduisant la resistance thermique apparente des interfaces thermiques et du systeme de refroidissement en aval vers le module de refroidissement. Actuellement, aucune installation ni methode ne semble exister afin de caracteriser les performances thermiques des recepteurs. Ce projet traite d'une nouvelle technique de caracterisation pour definir la diffusion thermique du recepteur a l'interieur d'un module de refroidissement. Des indices de performance sont issus de resistances thermiques mesurees experimentalement sur les modules. Une plateforme de caracterisation est realisee afin de mesurer experimentalement les criteres de performance. Cette plateforme injecte un flux thermique controle sur une zone localisee de la surface superieure du recepteur. L'injection de chaleur remplace le flux thermique normalement fourni par la cellule. Un systeme de refroidissement est installe

  3. Typical tumors of the petrous bone; Typische Tumoren des Felsenbeins

    Energy Technology Data Exchange (ETDEWEB)

    Ahlhelm, F.; Mueller, U. [Kantonsspital Baden AG, Abteilung fuer Neuroradiologie, Institut fuer Radiologie, Baden (Switzerland); Ulmer, S. [Medizinisch-Radiologisches Institut, Zuerich (Switzerland)

    2014-04-15

    In the region of the petrous bone, inner acoustic canal and cerebellopontine angle, a variety of different tissues can be found, such as bony, epithelial, neural and vascular structures. Tumorous or tumor-like lesions, vascular or bony malformations or other pathologies can therefore be found in all of these areas. We discuss various frequently occurring tumorous or tumor-like pathologies including congential lesions, such as mucoceles, inflammatory disorders including osteomyelitis, pseudotumors and Wegener's granulomatosis. Benign non-neoplastic lesions, such as cholesteatoma, cholesterol granuloma, epidermoid and benign neoplastic tumors, such as the most commonly found vestibular schwannoma, meningeoma, paraganglioma, vascular pathologies and finally malignant lesions, such as metastasis, chordoma or chondrosarcoma and endolymphatic sac tumor (ELST) are also discussed. The emphasis of this article is on the appearance of these entities in computed tomography (CT) and more so magnetic resonance imaging (MRI), it provides key facts and typical images and discusses possibilities how to distinguish these pathologies. (orig.) [German] In der Region des Felsenbein, inneren Gehoerkanals und Kleinhirnbrueckenwinkels findet sich eine Vielzahl an unterschiedlichen Gewebearten inklusive knoechernes, epitheliales, nervales und vaskulaeres Gewebe. Tumoren oder tumoraehnliche Laesionen, ossaere oder vaskulaere Pathologien koennen entsprechend dort gefunden werden. Wir diskutieren verschiedene Tumoren oder tumoraehnliche Pathologien inklusive angeborene Laesionen wie Muko- und Meningozelen, entzuendliche Veraenderungen wie die Osteomyelitis, Pseudotumoren, die Wegener-Granulomatose, nichtneoplastische Tumoren wie das Epidermoid, Cholesteatom oder Cholesterolgranulom und gutartige neoplastische Tumoren wie das am haeufigsten zu findende Vestibularisschwannom, das Paragangliom und das Meningeom, Gefaessprozesse/-pathologien und schliesslich maligne Laesionen wie Metastasen

  4. The origin of cholesterol in chyle demonstrated by nuclear indicator methods; Origines du cholesterol du chyle mises en evidence par la methode des indicateurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Vyas, M

    1962-07-01

    In order to obtain information about the mechanism of the intestinal absorption of cholesterol, rats having a lymphatic abdominal fistula are used. The animals receive either 4-{sup 14}C- cholesterol subcutaneously or orally, or the 1-{sup 14}C acetate. The study of the specific radio-activities of the cholesterol in chyle, in serum, in the lining, and in the intestinal contents makes it possible to define the roles played by the transfer cholesterol from the serum, by the cholesterol synthesised intestinally, and by the absorption cholesterol, in the formations of the lymph and of the chylomicrons. A new theory is proposed for the mechanism of cholesterol absorption. (author) [French] Pour obtenir des renseignements concernant le mecanisme de l'absorption intestinale du cholesterol, on utilise des rats porteurs d'une fistule lymphatique abdominale. Les animaux recoivent soit du cholesterol 4-{sup 14}C par voie sous-cutanee ou par voie orale, soit de l'acetate 1-{sup 14}C. L'etude des radioactivites specifiques du cholesterol du chyle, du serum, de la paroi et du contenu intestinal permet de preciser les roles joues par le cholesterol de transfert d'origine serique, par le cholesterol de synthese intestinale et par le cholesterol d'absorption, dans la formation de la lymphe et des chylomicrons. Une theorie nouvelle concernant le mecanisme de l'absorption du cholesterol est proposee. (auteur)

  5. Oxti-photo-battery: utilization of new oxygenated titanium polymers for the elaboration of thin photoactive films by sol-gel techniques. Realization of photovoltaic cells exempt from photo sensitizer and development of photo batteries. Concerted actions energy (PE1). Final report. July 2004; Oxti-photobatterie: Utilisation de nouveaux polymeres oxygenes du titane pour l'elaboration de films minces photoactifs par des techniques sol-gel. Realisation de cellules photovoltaiques exemptes de photosensibilisateurs et developpement de photobatteries. Action concertee energie (PE1). Rapport final. Juillet 2004

    Energy Technology Data Exchange (ETDEWEB)

    Brohan, L. [Laboratoire de Chimie des Solides, 44 - Nantes (France); Nunzi, J.M. [Angers Univ., Laboratoire des Proprietes Optiques des Materiaux et Applications, 49 - Angers (France)

    2004-07-01

    This coordinated project aims to elaborate new photovoltaic cells realized from a photosensitive titanium gel, called ''TiDMF''. This inorganic polymer, presents interesting optical properties: it takes a bleu color (by reduction of the Ti{sup 4+} in Ti{sup 3+}), after exposition to the day light. This particularity allows the realization of solar cells exempt from photo sensitizer. (A.L.B.)

  6. Quelle place pour la greffe de cellules souches haploidentiques et comment améliorer son efficacité clinique en manipulant, en post-transplantation, l’environnement cellulaire au moyen de l’utilisation de populations cellulaires sélectionnées ou de facteurs solubles modulant l’immunité ?/ The current place of haplo-identical stem cell transplantation and how to improve its clinical outcome by manipulation of the cellular environment post-transplant using selected cellular populations or immunomodulatory soluble factors

    OpenAIRE

    Lewalle, Philippe

    2011-01-01

    Currently, in most situations, the autologous immune system is unable to eradicate the residual leukemic burden persisting after chemo-radiotherapy, but a balance can be established between leukemic and immune cells leading to a clinical remission for several months or years. If this balance is broken, a clinical relapse can occur. The high incidence of relapses in human cancers demonstrates the frequent inefficacy of the immune system to control these residual cells. In this context, allogen...

  7. L'(E)TABLISSEMENT D'UN MOD(E)LE CELLULAIRE DE L'OLIGONUCL(E)OTIDE MUTANT

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objectif Pour établir un modèle cellulaire de l'oligonucléotide mutant. Méthodes Par rapport la prise du gène de la protéine de fluorescence verte et agrandisse (EGFP), nous induissons une mutation par la technique du point mutant de PCR pour changer du codon de 98ème position du gène egfp GAA au codon d' arrêt TAA , formant le gène egfp-D de mutant, donc on construit deux vecteurs de plasmides : pcDNA3-egfp et pcDNA3-egfp-D. Puis les plasmides sont transférés dans les cellules NIH-3T3 par le calcium de phosphate. Résultats Sous le microscope de fluorescence, on n'a pas vu l'expression de la EGFP dans tous les cellules transférées par l' egfp-D de mutant, et en même temps, les cellules transférées par l'egfp normal peuvent exprimer la EGFP. Ensuite on obtient les cellules stables par le criblage de G418. PCR confirme l'intégration du gène egfp-D dedans le génome ADN des cellules. RT-PCR et Northern blot analysent les gènes egfp et egfp-D peuvent transcrire normalement, il montre les cellules transférées par le gène egfp-D de mutant n'exprimant pas la fluorescence verte est parce que la traduction est terminée en avant. Conclusion Le modèle cellulaire de l'oligonucléotide mutant rapporté par le gène egfp est établi avec succès, ce modèle peut employer en recherche du système réparant thérapeutique via le chimeric ARN /ADN oligonucléotide (RDOs).

  8. Prevalencia del Enteroparasitismo en escolares de comunidades nativas del Alto Marañon, Amazonas, Perú

    Directory of Open Access Journals (Sweden)

    Nicanor Ibáñez H

    2004-07-01

    Full Text Available Objetivos: Determinar la prevalencia de infección por protozoarios y helmintos intestinales y su relación con el sexo, localidad de procedencia y grupo etáreo, en escolares nativos de la zona selvática del Alto Marañón, provincia de Bagua, departamento de Amazonas, Perú. Materiales y métodos: En este estudio transversal-observacional se seleccionó a los colegios representativos de la mencionada región lográndose examinar las muestras fecales de 1049 escolares de seis a 15 años de edad, entre octubre de 2001 y octubre de 2002, usando las técnicas microscópicas de observación directa, con solución salina fisiológica y lugol, de Teleman y de Kinnyoun. Resultados: La prevalencia de los protozoos y helmintos intestinales hallados es: Entamoeba coli 68,0%; Blastocystis hominis 28,4%; Endolimax nana 23,9%; Iodamoeba butschlii 32,9%; Giardia lamblia 21,4%; Entamoeba histolytica/dispar 12,9%; Cryptosporidium sp 01,9%; Paragonimus peruvianus 00,7% y Fasciola hepatica 00,2% (que no son parásitos intestinales sino de ubicación pulmonar y de vías biliares, respectivamente, pero sus huevos se encuentran en el contenido intestinal; Ancylostoma/Necartor 30,4%; Ascaris lumbricoides 28,9%; Trichocephalus trichiura 16,6%; Enterobius vermicularis 03,6%; Hymenolepis nana 03,5%; Taenia solium/saginata 00,2%; Strongyloides stercoralis 00,8% e H. diminuta 00,2%. Conclusiones: Ancylostoma/Necartor y A. lumbricoides se presentaron con mayor prevalencia en las poblaciones de menor edad de las comunidades de Mesones Muro y Nazaret, mientras que la infección humana por P. peruvianus se registra por primera vez en la región nororiental del Perú.

  9. Evaluación parasitológica de cuatro especies de vegetales utilizados en establecimientos de “comida rápida” en Coro, Falcón, Venezuela

    Directory of Open Access Journals (Sweden)

    Dalmiro Cazorla Perfetti

    2013-01-01

    Full Text Available En la actualidad, existe un incremento del consumo de comida fuera del núcleo familiar. Sin embargo, los vegetales que se consumen crudos en los establecimientos de “comida rápida” son un vehículo potencial para adquirir parásitos intestinales de interés médico-zoonótico. Entre enero y mayo de 2009, se evaluaron parasitológicamente mediante lavado con agua destilada estéril + Tween® 20 al 20 %, sedimentación espontánea por 24 horas, centrifugación y la observación microscópica de tinciones de lugol y Kinyoun, 45 muestras de vegetales correspondientes a 3 especies (tomate, lechuga, repollo y una mezcla (repollo + zanahoria de hortalizas, las cuales se obtuvieron al azar en 34 establecimientos de “comida rápida” de la ciudad de Coro, Estado Falcón, Venezuela. Se detectó una prevalencia global del 77,78 % (35/45, siendo el repollo (100 % y la lechuga (80 % las hortalizas que presentaron mayores porcentajes de contaminación parasitaria. Los parásitos intestinales más frecuentemente observados fueron: Entamoeba histolytica/dispar/moshkovskii (22,22 %, Blastocystis sp. (22,22 %, Giardia sp. (20,00 % y los Ancylostomídeos (13,33 %. No se encontró una relación estadísticamente significativa y directa entre los porcentajes de contaminación y las variables epidemiológicas evaluadas (p > 0,05, sugiriendo que otros factores, tanto abióticos como bióticos, incluyendo los sinantrópicos, podrían estar influenciando en la contaminación de las hortalizas. Se recomienda implementar un plan sanitario más estricto en los establecimientos de “comida rápida”, y programas de educación para la salud de la población a mayor riesgo de adquirir las parasitosis intestinales.

  10. Evaluación parasitológica de cuatro especies de vegetales utilizados en establecimientos de “comida rápida” en Coro, Falcón, Venezuela

    Directory of Open Access Journals (Sweden)

    Dalmiro Cazorla Perfetti

    2013-06-01

    Full Text Available En la actualidad, existe un incremento del consumo de comida fuera del núcleo familiar. Sin embargo, los vegetales que se consumen crudos en los establecimientos de “comida rápida” son un vehículo potencial para adquirir parásitos intestinales de interés médico-zoonótico. Entre enero y mayo de 2009, se evaluaron parasitológicamente mediante lavado con agua destilada estéril + Tween® 20 al 20 %, sedimentación espontánea por 24 horas, centrifugación y la observación microscópica de tinciones de lugol y Kinyoun, 45 muestras de vegetales correspondientes a 3 especies (tomate, lechuga, repollo y una mezcla (repollo + zanahoria de hortalizas, las cuales se obtuvieron al azar en 34 establecimientos de “comida rápida” de la ciudad de Coro, Estado Falcón, Venezuela. Se detectó una prevalencia global del 77,78 % (35/45, siendo el repollo (100 % y la lechuga (80 % las hortalizas que presentaron mayores porcentajes de contaminación parasitaria. Los parásitos intestinales más frecuentemente observados fueron: Entamoeba histolytica/dispar/moshkovskii (22,22 %, Blastocystis sp. (22,22 %, Giardia sp. (20,00 % y los Ancylostomídeos (13,33 %. No se encontró una relación estadísticamente significativa y directa entre los porcentajes de contaminación y las variables epidemiológicas evaluadas (p > 0,05, sugiriendo que otros factores, tanto abióticos como bióticos, incluyendo los sinantrópicos, podrían estar influenciando en la contaminación de las hortalizas. Se recomienda implementar un plan sanitario más estricto en los establecimientos de “comida rápida”, y programas de educación para la salud de la población a mayor riesgo de adquirir las parasitosis intestinales.

  11. Effet photovoltaïque dans des couches minces de phtalocyanines

    OpenAIRE

    Khelifi, M.; Mejatty, M.; Berrehar, J.; Bouchriha, H.

    1985-01-01

    Nous avons élaboré des cellules photovoltaiques utilisant des couches minces de phtalocyanines entre deux contacts métalliques en or et en aluminium (Al/MPc/Au). Ces couches absorbent fortement dans l'ultraviolet et le visible, les coefficients d'absorption étant de l'ordre de 105 cm-1. Le spectre d'action de ces cellules dépend à la fois du côté de l'éclairement et de l'épaisseur de la couche. Nous avons montré que c'est le contact Al/MPc qui est actif dans le mécanisme de création des porte...

  12. Amélioration de l’efficacité de l’absorption du rayonnement solaire photovoltaïque par utilisation des nanostructures.

    OpenAIRE

    TRAORE Soumaïla, Amara

    2014-01-01

    L’absorption complète de la lumière solaire dans le silicium cristallin nécessite une épaisseur de matériau de l’ordre de 500 microns, une large fraction de la lumière est perdue par transmission lorsque l’épaisseur de matériau diminue en deçà de 10 microns. Les cellules photovoltaïques en couches minces (cellules de 2ème génération) tentent de contourner les difficultés rencontrées par cette traditionnelle technologie en minimisant la quantité de matière active semi-conductrice par kWh insta...

  13. Etude thermodynamique et de R.M.N. des mélanges liquides d'hélium 3 polarisé dans l'hélium 4

    OpenAIRE

    Stoltz, Eric

    1996-01-01

    Le pompage optique laser des mélanges gazeux d'hélium peut fournir, dans un champ magnétique faible, de fortes valeurs de polarisation nucléaire. Une technique thermique efficace qui permet la circulation des atomes d'hélium 3 dans la cellule expérimentale rend possible le transfert, en régime stationnaire, de la polarisation nucléaire du gaz à un échantillon liquide à basse température. La relaxation sur les parois de la cellule est efficacement réduite par l'utilisation de césium métallique...

  14. Radionuclide imaging in the evaluation of osteomyelitis and septic arthritis

    International Nuclear Information System (INIS)

    Despite controversy over its exact role, radionuclide imaging plays an important role in the evaluation of patients suspected of having osteomyelitis. The differentiation between osteomyelitis and cellulitis is best accomplished by using a three-phase technique using Tc-99m methylene diphosphonate (MDP). Frequently, it is necessary to obtain multiple projections and magnification views to adequately assess suspected areas. It is recommended that a Ga-67 or In-111 leukocyte scan be performed in those cases where osteomyelitis is strongly suspected clinically and the routine bone scan is equivocal or normal. Repeated bone scan after 48 to 72 h may demonstrate increased radioactivity in the case of early osteomyelitis with the initial photon-deficient lesion. In-111 leukocyte imaging is useful for the evaluation of suspected osteomyelitis complicating recent fracture or operation, but must be used in conjunction with clinical and radiographic correlation. The recognition of certain imaging patterns appears helpful to separate osteomyelitis from septic arthritis or cellulitis. 83 references

  15. Applications d'une modulation pharmacologique des dérives des formes réactives de l'oxygène pour une optimisation thérapeutique des patients traités par chimiothérapie

    OpenAIRE

    Coriat, Romain

    2012-01-01

    Les formes réactives de l’oxygène (FRO) ont un rôle bien établi dans l’oncogénèse et le fonctionnement des cellules tumorales en augmentant les capacités de prolifération et d’invasion cellulaire. Les FRO présentent une moindre toxicité dans les cellules normales où le niveau de stress oxydant est bas et les systèmes d’oxydoréduction opérationnels. Une modulation pharmacologique de l’équilibre d’oxydoréduction permet d’améliorer l’efficacité des molécules cytotoxiques qui agissent sur les FRO...

  16. Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets

    OpenAIRE

    Riffault, S; CARRAT, C.; Van Reeth, K.; Pensaert, M; CHARLEY, B.

    2001-01-01

    Les cellules productrices d'interféron alpha chez les porcelets infectés par le virus GET sont localisées dans les tissus lymphoïdes associés à l'intestin. La gastroentérite transmissible (GET) du porcelet est une infection virale qui entraîne une production précoce et intense d'interféron alpha (IFN-$\\alpha$), tant au niveau du sérum que des sécrétions des animaux infectés. Le but de ce travail a été de caractériser les cellules productrices d'IFN-$\\alpha$ dans les tissus des porcelets infec...

  17. Pelvic Surgical Site Infections in Gynecologic Surgery

    Directory of Open Access Journals (Sweden)

    Mark P. Lachiewicz

    2015-01-01

    Full Text Available The development of surgical site infection (SSI remains the most common complication of gynecologic surgical procedures and results in significant patient morbidity. Gynecologic procedures pose a unique challenge in that potential pathogenic microorganisms from the skin or vagina and endocervix may migrate to operative sites and can result in vaginal cuff cellulitis, pelvic cellulitis, and pelvic abscesses. Multiple host and surgical risk factors have been identified as risks that increase infectious sequelae after pelvic surgery. This paper will review these risk factors as many are modifiable and care should be taken to address such factors in order to decrease the chance of infection. We will also review the definitions, microbiology, pathogenesis, diagnosis, and management of pelvic SSIs after gynecologic surgery.

  18. Altérations génétiques et épigénétiques dans la leucémie myélomonocytaire chronique - Modulation par les agents déméthylants

    OpenAIRE

    Merlevede, Jane

    2015-01-01

    La leucémie myélomonocytaire chronique (LMMC) est une pathologie clonale de la cellule souche hématopoïétique qui touche principalement les personnes âgées. Le seul traitement curatif de cette maladie est la greffe allogénique de cellules souches hématopoïétiques, souvent difficile à mettre en oeuvre. Les patients qui ne peuvent être greffés et dont la maladie présente des critères de gravité se voient proposer un agent déméthylant de l'ADN. Chez 30 à 40% d'entre eux, ce traitement induit une...

  19. Morganella morganii in sinonasal region: A rare case report

    Directory of Open Access Journals (Sweden)

    Haşmet Yazıcı

    2013-09-01

    Full Text Available Morganella morganii is a gram negative pathogen andmay cause potentially lethal disease especially in patientswith underlying or immunosuppressive disease. It is commonlyfound in long-term urinary catheter used and immunesystem deficiency patients as nosocomial disease.Involving other systems such as skin, skeletal systemand central nervous system can be seen too. Sporadicoccurrence is rare and can be seen in any system by variouscauses like AIDS, snake bites and poisoning. In thiscase we present sporadic Morganella morganii infectionon sinonasal region with the presence of sinusitis, sinocutaneousfistula, preseptal cellulitis and hard palate defecton 58 year old male diabetic patient. Microbiologicalassessment from open wound and sinuses were reportedas Morganella morganii. To our knowledge, this is the firstcase of sino-nasal Morganella morganii infection with sino-cutaneous fistula, preseptal cellulitis and maxillofacialbone destruction. J Clin Exp Invest 2013; 4 (3: 383-386Key words: Morganella Morganii, sino-nasal fistula, preseptalcellulitis, bone destruction

  20. Thin film microcrystalline silicon layers and solar cells: microstructure and electrical performances

    OpenAIRE

    Droz, Corinne; Shah, Arvind

    2004-01-01

    Le silicium microcristallin hydrogéné (mc?Si:H), tel que fabriqué par la technique de dépôt chimique en phase vapeur assisté par plasma à très haute fréquence (VHF PE-CVD), est maintenant utilisé avec succès en tant que couche active dans des cellules solaires. Cependant, une question fondamentale concerne le lien entre la microstructure du matériau, d'une part, et les propriétés de transport électronique des couches intrinsèques ainsi que les performances électriques des cellules solaires, d...

  1. Structuration d'un peuplement hétérogène au moyen d'éclaircies locales

    OpenAIRE

    Pierrat, J. C.

    2004-01-01

    Nous présentons un modèle de martelage basé sur des règles locales et ajustons ses paramètres pour rechercher un peuplement de structure déterminée. Le peuplement initial est divisé en cellules d'un nombre constant d'arbres. Une cellule est décrite par les nombres de tiges par classe de diamètre pour chaque essence. Ces variables sont aléatoires, de loi de probabilité modélisée par un mélange de distributions multinomiales, de paramètres connus ou estimés à partir d'un peuplement réel. Les ob...

  2. Exosomes neuronaux: sécrétion de protéines membranaires impliquées dans les processus physiologiques et pathologiques du système nerveux.

    OpenAIRE

    Moisand Lachenal, Gaelle

    2009-01-01

    Les exosomes sont des microvésicules sécrétées par les cellules après la fusion des endosomes multivésiculaires avec la membrane plasmique. Ils permettent le transfert intercellulaire de protéines, mais aussi de lipides et d'ARN. Ils sont particulièrement étudiés dans le système immunitaire, car ils permettent la mise en route d'une réponse anti-tumorale par l'échange de molécules du CMH entre cellules dendritiques. Nous nous sommes intéressés au rôle que les exosomes pourraient jouer dans le...

  3. Gadolinium-DTPA-enhanced magnetic resonance imaging of musculoskeletal infectious processes

    International Nuclear Information System (INIS)

    The purpose of this study was to assess whether gadolinium-enhanced magnetic resonance imaging (MRI) provides diagnostic information beyond that given by nonenhanced imaging in the evaluation of musculoskeletal infectious processes and whether it can be used for differentiating infectious from noninfectious inflammatory lesions. Magnetic resonance images performed with and without intravenous gadolinium-DTPA in 34 cases in which musculoskeletal infection had been clinically suspected were reviewed. Infectious lesions-including osteomyelitis, pyarthrosis, abscess, and cellulitis-were confirmed in a total of 22 cases: in 15 by biopsy or drainage and in 7 by clinical course. Our results show that gadolinium-DTPA-enhanced MRI is a highly sensitive technique in diagnosing musculoskeletal infectious lesions. It is especially useful in distinguishing abscesses from surrounding cellulitis/myositis. Lack of contrast enhancement rules out infection with a high degree of certainty. However, contrast enhancement cannot be used to reliably distinguish infectious from noninfectious inflammatory conditions. (orig.)

  4. Continuous cell lines and immune ascitic fluid pools in arbovirus detection

    OpenAIRE

    Digoutte, J. P.; Calvo-Wilson, M.A.; Mondo, M.; Traore-Lamizana, Moumouni; Adam, François

    1992-01-01

    Pour la recherche et l'isolement des arbovirus, des expérimentations successives nous ont amenés à utiliser, parmi les lignées de cellules en culture continue dont l'utilisation est préconisée par l'OMS, les deux systèmes cellulaires MOS61 (cellules de #Aedes pseudoscutellaris$) et Vero. La détection des virus dans les sytèmes cellulaires est réalisée à l'aide de 7 pools de 10 ascites hyperimmunes polyvalentes. Cette technique permet la mise en évidence de 70 sur 80 arbovirus transmis par le...

  5. Projet de pasteurisateur à refroidissement intégré pour la restauration

    OpenAIRE

    Knockaert, Camille

    1989-01-01

    Il n'existe pas sur le marché de matériel fonctionnant de manière satisfaisante pour pratiquer la technique de cuisson sous vide à petite échelle. Les restaurateurs souhaitant utiliser ce procédé n'ont à leur disposition que de petites cellules alimentées à la vapeur et l'air chaud combinés. Ces appareils se caractérisent par deux défauts majeurs : - l'hétérogénéïté du chauffage, - l'impossibilité de refroidir dans la même cellule. Compte tenu des risques encourus par la pratique de ...

  6. Cervical celullitis in broiler chickens for Escherichia coli/ Celulite cervical em frangos de corte causada por Escherichia coli

    Directory of Open Access Journals (Sweden)

    Ivens Gomes Guimarães

    2002-05-01

    Full Text Available In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frangos de corte apresentando lesão de celulite na região cervical. Foi realizado o isolamento de E. coli da lesão de celulite e realizado exames histopatológicos que caracterizaram a lesão. Na epiderme foram verificadas lesões ulcerativas, presença de fibrina na derme e infiltração difusa de linfócitos e heterófilos no tecido subcutâneo.

  7. Orbital abscess secondary to acute dacryocystitis: case report Abscesso orbitário secundário à dacriocistite aguda: relato de caso

    Directory of Open Access Journals (Sweden)

    Marcia Clivati Martins

    2008-08-01

    Full Text Available Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao conteúdo orbitário resultando em celulite orbitária. Apresentamos um caso de abscesso orbitário intraconal secundário à dacriocistite aguda e uma revisão de literatura de celulite orbitária causada por infecção aguda do saco lacrimal.

  8. DNA damage-dependent regulation of MyoD function

    OpenAIRE

    Simonatto, Marta

    1980-01-01

    Durante la rigenerazione muscolare, le cellule progenitrici sono esposte ad una serie di stimoli extracellulari che coordinano la loro attivazione, proliferazione e differenziamento. Al tempo stesso, tuttavia, l’ambiente rigenerativo, stimolando la sintesi del DNA e aumentando lo stato di ossidazione intracellulare, costituisce una fonte di stress genotossico, come mostriamo in vivo in questo lavoro. Uno studio svolto in precedenza nel nostro laboratorio ha identificato e ca...

  9. Functional Analysis of the Degradation of Cellulosic Substrates by a Chaetomium globosum Endophytic Isolate

    OpenAIRE

    Longoni, Paolo; Rodolfi, Marinella; Pantaleoni, Laura; Doria, Enrico; Concia, Lorenzo; Picco, Anna Maria; Cella, Rino

    2012-01-01

    Most photosynthetically fixed carbon is contained in cell wall polymers present in plant biomasses, the largest organic carbon source in the biosphere. The degradation of these polymers for biotechnological purposes requires the combined action of several enzymes. To identify new activities, we examined which enzymes are activated by an endophytic strain of Chaetomium globosum to degrade cellulose-containing substrates. After biochemical analyses of the secretome of the fungus grown on cellul...

  10. Tau nucleare: un possibile nuovo target per la terapia della malattia di Alzheimer

    OpenAIRE

    Passarella, Daniela

    2013-01-01

    Tau è una proteina stabilizzatrice i microtubuli identificata in entrambi i compartimenti cellulari, quello citosolico/citoscheltrico e quello nucleare, di cellule neuronali e non neuronali; si contraddistingue per la sua fosforilazione altamente regolata in eventi sia fisiologici (per esempio durante mitosi), che patologici (come negli aggregati neurofibrillari). Nella malattia dell’Alzheimer (AD) non è stato ancora stabilito se gli aggregati neurofibrillari rappresentano una causa o una co...

  11. Pott′s puffy tumor following an insect bite

    Directory of Open Access Journals (Sweden)

    Raja V

    2007-01-01

    Full Text Available Pott′s puffy tumor, a feature of osteomyelitis of the frontal bone, is a rare entity, especially in adults. Sir Percival Pott originally described this condition as a complication of trauma to the frontal bone. This is also a recognized complication of fronto-ethmoidal sinusitis. We present a rare case of Pott′s puffy tumor caused by an insect bite presenting initially as a preseptal cellulitis and explore its pathogenesis and management.

  12. Radionucleotide scanning in osteomyelitis

    International Nuclear Information System (INIS)

    Radionucleotide bone scanning can be an excellent adjunct to the standard radiograph and clinical findings in the diagnosis of osteomyelitis. Bone scans have the ability to detect osteomyelitis far in advance of the standard radiograph. The sequential use of technetium and gallium has been useful in differentiating cellulitis and osteomyelitis. Serial scanning with technetium and gallium may be used to monitor the response of osteomyelitis to antibiotic therapy

  13. Neglected Foreign Body, the Cause of Navicular Osteomyelitis in A Paediatric Foot: A Case Report

    OpenAIRE

    Chandrashekara C.M; George M.A; Bader Said Khamis Al-Marboi

    2013-01-01

    Introduction: Foreign body injuries with date thorns, metal and wooden splinters are common in Middle East region, as most of it is desert. Some of the injuries lead to cellulitis or abscess formation, if neglected or improperly managed results in osteomyelitis or septic arthritis of foot structures. This is the first report of isolated navicular osteomyelitis following neglected foreign body in a paediatric foot. Case Report: A 10 year old male patient presented with discharging sinus in...

  14. Clinical efficacy and safety of cefmenoxime in children.

    OpenAIRE

    Tansino, G F; Hammerschlag, M R; Congeni, B L; Cox, P.A.; Doraiswamy, B; duBouchet, L

    1985-01-01

    Cefmenoxime, an investigational semisynthetic cephalosporin, was evaluated in 18 pediatric patients with a variety of infections. There were seven patients with urinary tract infections, two with wound infections, two with osteomyelitis, two with abscess infections, one with cervical adenitis, one with hidradenitis, one with pneumonia and sepsis, one with periorbital cellulitis, and one with ventriculitis. A total of 16 (88%) patients had a satisfactory clinical response demonstrated by impro...

  15. Acute sialadenitis in children and adolescents: CT findings and clinical manifestations according to glandular involvement

    International Nuclear Information System (INIS)

    This study was designed to compare the CT findings and clinical manifestations in children and adolescents with acute sialadenitis according to the involved salivary glands. The study included fifty children and adolescents (34 boys, 16 girls) with acute sialadenitis that was diagnosed during the past five years. All of the subjects were divided into three groups: group I (parotid gland involvement, n = 16), group II (submandibular gland involvement, n = 20) and group III (involvement of both glands, n 14). We analyzed the presence of an abscess, sialolith, bilaterality, cellulitis and lymphadenopathy on CT scans. The analyzed clinical data were age, sex, lymphadenopathy, pain, swelling, presence of a mass, tonsillitis, treatment period and surgical treatment if it was performed. The presence of an abscess, sialolith, cellulitis, swelling, age, presence of a palpable mass and treatment period were statistically significant factors for the patients in the three groups. An abscess was combined only in group I patients. There was a high rate of sialolith in group II patients and cellulitis in group III patients as seen on CT scans. Swelling in group II patients and group III patients and the presence of a palpable mass in group I patients were identified as clinical manifestations. Age was younger in group I patients (mean age, 5.3 years) than in group II patients (mean age, 12.9 years) and group III patients (mean age, 15.2 years). The treatment period was longer for group I patients. For acute sialadenitis in children and adolescents, age, presence of an abscess, sialolith, cellulitis, swelling, presence of a palpable mass and treatment period were different according to the involved salivary glands

  16. Follicular occlusion tetrad

    OpenAIRE

    Vani Vasanth; Byalakere Shivanna Chandrashekar

    2014-01-01

    Follicular occlusion tetrad is a symptom complex consisting of four conditions having a similar pathophysiology. It includes Hidradenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp and pilonidal sinus. The exact pathogenesis of this group of disease is unknown but evidence suggests that they share the same pathological process initiated by follicular occlusion in apocrine gland bearing areas. Though each of these conditions is commonly encountered singly, follicular occl...

  17. Lysinuric proetin intolerance: molecular and cellular bases of an inherited multi-system disorder

    OpenAIRE

    Sperandeo, Maria Pia

    2006-01-01

    [ITALIANO] Introduzione: L’ intolleranza alle proteine con lisinuria, ereditata come carattere autosomico recessivo, è causata da un difettivo trasporto di aminoacidi cationici (CAA) alla membrana basolaterale delle cellule epiteliali di intestino e rene. I pazienti sono usualmente asintomatici durante il periodo dell'allattamento; dopo lo svezzamento, allorché il contenuto dell’ apporto proteico aumenta, si manifestano i segni clinici della malattia: vomito, diarrea, epatosplenomegalia, oste...

  18. Bacteremia due to Agrobacterium tumefaciens (radiobacter). Report of infection in a pregnant women and her stillborn fetus.

    Science.gov (United States)

    Southern, P M

    1996-01-01

    Agrobacterium tumefaciens (radiobacter) is usually a plant pathogen, but is isolated occasionally from human clinical specimens, frequently along with other bacteria. Agrobacterium tumefaciens (radiobacter) has been isolated from blood, central intravenous catheters, peritoneal fluid, urine, and cellulitis aspirates, often in immunocompromised individuals. This report details the isolation of A. tumefaciens (radiobacter) from the blood of a pregnant woman, as well as from the blood of her stillborn, premature fetus. It is, to our knowledge, the first report of such an occurrence. PMID:8988763

  19. Musculoskeletal infections: ultrasound appearances

    Energy Technology Data Exchange (ETDEWEB)

    Chau, C.L.F. [Department of Radiology, North District Hospital, NTEC, Fanling, NT, Hong Kong (China)]. E-mail: c8681@yahoo.com; Griffith, J.F. [Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, NTEC, Shatin, NT, Hong Kong (China)

    2005-02-01

    Musculoskeletal infections are commonly encountered in clinical practice. This review will discuss the ultrasound appearances of a variety of musculoskeletal infections such as cellulitis, infective tenosynovitis, pyomyositis, soft-tissue abscesses, septic arthritis, acute and chronic osteomyelitis, and post-operative infection. The peculiar sonographic features of less common musculoskeletal infections, such as necrotizing fasciitis, and rice body formation in atypical mycobacterial tenosynovitis, and bursitis will also be presented.

  20. Hyaluronidase hypersensitivity: A rare complication of peribulbar block

    Directory of Open Access Journals (Sweden)

    A R Rajalakshmi

    2016-01-01

    Full Text Available Peribulbar block, though safe, can cause serious complications such as globe perforation and peribulbar hemorrhage. Hyaluronidase is an enzyme that is used as an adjuvant in peribulbar anesthesia, and it helps in rapid penetration of the anesthetic agent. Hypersensitivity to hyaluronidase is a rare but potentially sight-threatening complication. We report a case of hyaluronidase hypersensitivity following peribulbar injection for cataract surgery mimicking as peribulbar hematoma in the immediate postinjection phase and as orbital cellulitis 48 h later.

  1. INTERAZIONE COMPLEMENTO-ENDOTELIO NELLA FLOGOSI

    OpenAIRE

    Bossi, Fleur

    2005-01-01

    Numerose molecole circolanti nel sangue possono interagire con l'endotelio portando all'attivazione della cascata della coagulazione o all'insorgenza dei fenomeni proinfiammatori. Tra le molecole che possono reagire con le cellule endoteliali (EC) ci sono anche i prodotti di attivazione del sistema del complemento (C). Il sistema del C è un componente dell'immunità naturale, che svolge un ruolo essenziale nella difesa contro agenti infettivi e nella rimozione degli immunocomplessi, e rapprese...

  2. Cellular Mechanisms Underlying Hippocampal CA1 Place Cell Activity

    OpenAIRE

    Fallahnezhad, Mehdi

    2015-01-01

    Norsk Sammendrag: Nerveceller er de grunnleggende byggesteinene i hjernen hos pattedyr og deres aktivitet fører til hjernefunksjoner. Aktivitetsmønsteret til en nervecelle, slik som det romlige fyringsmønsteret laget av en stedcelle i hippocampus, oppstår gjennom samspillet mellom inngangsaktiviteten fra presynaptiske nerveceller og de molekylære mekanismene i nervecellen (cellulær mekanisme). Til tross for omfattende karakterisering av stedcelleaktivitet er ikke de underligge...

  3. How cellulose stretches: synergism between covalent and hydrogen bonding

    OpenAIRE

    Altaner, Clemens M.; Thomas, Lynne H.; Fernandes, Anwesha N; Jarvis, Michael C.

    2014-01-01

    Cellulose is the most familiar and most abundant strong biopolymer, but the reasons for its outstanding mechanical performance are not well understood. Each glucose unit in a cellulose chain is joined to the next by a covalent C–O–C linkage flanked by two hydrogen bonds. This geometry suggests some form of cooperativity between covalent and hydrogen bonding. Using infrared spectroscopy and X-ray diffraction, we show that mechanical tension straightens out the zigzag conformation of the cellul...

  4. Treatment of hospitalized patients with complicated skin and skin structure infections: double-blind, randomized, multicenter study of piperacillin-tazobactam versus ticarcillin-clavulanate. The Piperacillin/Tazobactam Skin and Skin Structure Study Group.

    OpenAIRE

    Tan, J S; Wishnow, R M; Talan, D A; Duncanson, F P; Norden, C W

    1993-01-01

    We compared the efficacy and safety of two beta-lactam-beta-lactamase inhibitor combinations, namely, piperacillin-tazobactam and ticarcillin-clavulanate, in the treatment of complicated bacterial infections of skin that required hospitalization. The study was a randomized, double-blind, comparative trial involving 20 centers. The infections were classified as (i) cellulitis with drainage, (ii) cutaneous abscess, (iii) diabetic or ischemic foot infection, and (iv) infected wounds and ulcers w...

  5. Self-organized criticality in boson clouds around black holes

    OpenAIRE

    Mocanu, Gabriela-Raluca; Grumiller, Daniel

    2012-01-01

    Boson clouds around black holes exhibit interesting physical phenomena through the Penrose process of superradiance, leading to black hole spin-down. Axionic clouds are of particular interest, since the axion Compton wavelength could be comparable to the Schwarzschild radius, leading to the formation of "gravitational atoms" with a black hole nucleus. These clouds collapse under certain conditions, leading to a "Bosenova". We model the dynamics of such unstable boson clouds by a simple cellul...

  6. Indagine retrospettiva sulle neoplasie testicolari del cane in Abruzzo e Molise, Italia

    OpenAIRE

    Anna Rita D’Angelo; Serafina Vita; Giuseppe Marruchella; Gabriella Di Francesco

    2012-01-01

    Le neoplasie testicolari sono piuttosto frequenti nel cane e condividono alcune caratteristiche con quelle umane, rendendole un potenziale modello in patologia comparata. Si riportano i dati relativi ai tumori testicolari del cane conferiti ed esaminati Istituto G. Caporale nel corso degli ultimi 12 anni, dal 2000 al 2011. In totale, sono stati diagnosticati 183 tumori: 108 seminomi, 37 sertoliomi, 18 tumori a cellule interstiziali del Leydig, 10 tumori misti, 9 neoplasie primitive di diversa...

  7. Imaging of normal and pathologic joint synovium using nonlinear optical microscopy as a potential diagnostic tool

    OpenAIRE

    Tiwari, Nivedan; Chabra, Sanjay; Mehdi, Sheherbano; Sweet, Paula; Krasieva, Tatiana B.; Pool, Roy; Andrews, Brian; Peavy, George M.

    2010-01-01

    An estimated 1.3 million people in the United States suffer from rheumatoid arthritis (RA). RA causes profound changes in the synovial membrane of joints, and without early diagnosis and intervention, progresses to permanent alterations in joint structure and function. The purpose of this study is to determine if nonlinear optical microscopy (NLOM) can utilize the natural intrinsic fluorescence properties of tissue to generate images that would allow visualization of the structural and cellul...

  8. Lime-induced phytophotodermatitis

    Directory of Open Access Journals (Sweden)

    Andrew Hankinson

    2014-09-01

    Full Text Available This case describes a scenario of lime-induced phytophotodermatitis. Phytophotodermatitis is a dermatitis caused after the skin is exposed to photosensitizing compounds in plants and then exposed to sunlight. Many common plants including citrus fruits, celery, and wild parsnip contain these photosensitizing compounds which cause phytophotodermatitis. It is important for a physician to be aware of phytophotodermatitis because it may often be misdiagnosed as other skin conditions including fungal infection, cellulitis, allergic contact dermatitis, and even child abuse.

  9. Lime-induced phytophotodermatitis.

    Science.gov (United States)

    Hankinson, Andrew; Lloyd, Benjamin; Alweis, Richard

    2014-01-01

    This case describes a scenario of lime-induced phytophotodermatitis. Phytophotodermatitis is a dermatitis caused after the skin is exposed to photosensitizing compounds in plants and then exposed to sunlight. Many common plants including citrus fruits, celery, and wild parsnip contain these photosensitizing compounds which cause phytophotodermatitis. It is important for a physician to be aware of phytophotodermatitis because it may often be misdiagnosed as other skin conditions including fungal infection, cellulitis, allergic contact dermatitis, and even child abuse. PMID:25317269

  10. Use of the catheter in treatment of panophthalmitis and orbital purulent inflammation

    OpenAIRE

    Nabil Al Hassan; Meliha Alender; Vesna Jurišić; Senija Rašić; Mirsad Ibišević; Emina Alimanović Halilović

    2008-01-01

    In this study we have presented three cases with use of a catheter placed intraoperatively as a possiblemethod of medicaments application in the retrobulbar region. Two patients developed panophthalmitis,abscess and cellulitis of the orbit as a consequence of an injury afflicted during the war whereas thethird patient with glaukoma developed endogenic endophthalmitis. We eviscerated the bulb, implantedsmall soft tubes (catheters), then brought them out and fixed to the skin of the orbit regio...

  11. Tropical diabetes hand syndrome with autoamputation of the digits: case report and review of literature

    OpenAIRE

    Raimi, Taiwo Hussean; Alese, Oluwole Ojo

    2014-01-01

    The tropical diabetes hand syndrome is a complication affecting patients with diabetes mellitus in the tropics, and consists of localized cellulitis, swelling and ulceration of the hands which may progress to fulminant sepsis and gangrene of the whole limb. It is associated with a poor outcome. We report a 32 year old woman with tropical diabetes hand infection with autoamputation of the digits, review the relevant literature, and highlight the need for prevention and early hospital presentat...

  12. The Function of the CLE Peptides in Plant Development and Plant-Microbe Interactions

    OpenAIRE

    Betsuyaku, Shigeyuki; Sawa, Shinichiro; Yamada, Masashi

    2011-01-01

    The CLAVATA3 (CLV3)/ENDOSPERM SURROUNDING REGION (ESR) (CLE) peptides consist of 12 or 13 amino acids, including hydroxylated proline residues that may or may not contain sugar modifications, and function in a non-cell-autonomous fashion. The CLE gene was first reported in Zea mays (maize) as an endosperm-specific gene, ESR, in 1997 (Opsahl-Ferstad et al., 1997). CLE genes encode secreted peptides that function in the extracellular space as intercellular signaling molecules and bind to cellul...

  13. Effect of Lyophilization and Freeze-thawing on the Stability of siRNA-liposome Complexes

    OpenAIRE

    Yadava, Preeti; Gibbs, Melissa; de Castro, Carlos; Hughes, Jeffrey A.

    2007-01-01

    The purpose of this research was to describe the application of lyophilization in the delivery of siRNA using cationic lipids by addressing the long-term formulation/stability issues associated with cationic lipids and to understand the mechanism of lyoprotection. siRNA liposomes complexes were formed in different potential cyro/lyoprotectants and subjected to either lyophilization or freeze thaw cycles. siRNA, liposomes and/or lipoplexes were tested for activity, SYBR Green I binding, cellul...

  14. Analisi molecolare con Risonanza Magnetica Nucleare del tessuto miocardico in pazienti affetti da malattia di Anderson-Fabry: valore aggiunto della Risonanza Magnetica Cardiaca nell'identificazione e nel follow-up dei pazienti affetti da malattia di Anderson-Fabry in trattamento con enzima ricombinante agalsidase beta a dopo "switch therapy" con agalsidase alfa

    OpenAIRE

    Messalli, Giancarlo

    2013-01-01

    Scopo La malattia di Anderson-Fabry è determinata da un disordine multi-sistemico del metabolismo lipidico dovuta alla carenza dell’enzima idrolitico α-galactosidase A (α-Gal A), secondario ad una alterazione del cromosoma X, che provoca un accumulo di “globotriaosylceramide” (Gb3) nelle cellule e nei tessuti in genere per malfunzionamento dei lisosomi. Tale accumulo provoca danni al cuore, ai reni ed al sistema cerebro-vascolare. In particolare la mancata degradazione dei glicosfingolipid...

  15. Nocardial mycetoma: Diverse clinical presentations

    OpenAIRE

    Sharma Nand; Mahajan Vikram; Agarwal Santwana; Katoch Vishwa; Das Ram; Kashyap Meera; Gupta Poonam; Verma Ghanshyam

    2008-01-01

    Nocardia spp are gram-positive, aerobic, acid-fast bacteria which exist as saprophytes in nature. Invasive disseminated infections are particularly common in immunocompromised or debilitated hosts. Superficial infections with Nocardia spp occur as a result of local trauma and contamination of the wound. Clinically, it presents as acute infection (abscesses or cellulitis), mycetoma, or sporotrichoid infection. Differential diagnosis includes eumycetoma, chromomycosis, blastomycosis, coccidioid...

  16. Shewanella and Photobacterium spp. in Oysters and Seawater from the Delaware Bay▿

    OpenAIRE

    Gary P. Richards; Watson, Michael A.; Crane, Edward J.; Burt, Iris G.; Bushek, David

    2008-01-01

    Shewanella algae, S. putrefaciens, and Photobacterium damselae subsp. damselae are indigenous marine bacteria and human pathogens causing cellulitis, necrotizing fasciitis, abscesses, septicemia, and death. Infections are rare and are most often associated with the immunocompromised host. A study was performed on the microbiological flora of oysters and seawater from commercial oyster harvesting sites in the Delaware Bay, New Jersey. From 276 water and shellfish samples tested, 1,421 bacteria...

  17. Studio molecolare e funzionale di nuove molecole bioattive al fine di veicolare biosubstrati a scopo diagnostico e terapeutico

    OpenAIRE

    Duce, Elenia

    2008-01-01

    Con la rapida conclusione del progetto relativo alla definizione della sequenza del genoma umano, il principio di curare le malattie di origine genetica dispensando i geni corretti alle cellule interessate si è fatto strada come strategia alternativa all'uso di farmaci di sintesi. La terapia genica, uno dei più rilevanti obiettivi che la ricerca post-genomica si prefigge, si basa sul principio di curare la malattia, determinata da un gene difettoso noto, introducendo il gene corretto nelle ce...

  18. "Ruolo dei fattori angiogenetici e dei peptidi vasoattivi nella fisiopatologia ostetrico-ginecologica"

    OpenAIRE

    Cerrota, Giuseppe

    2009-01-01

    In questo studio abbiamo voluto valutare il coinvolgimento di fattori angiogenetici, metalloproteinasi e peptidi vasoattivi nella patogenesi di tre patologie di vasta importanza nella pratica ostetrico-ginecologica, quali l’endometriosi,la pre-eclampsia e l’IUGR, che riconoscono nel loro movens patogenetico il coinvolgimento della angiogenesi. A questo scopo abbiamo valutato il potenziale “invasivo” delle cellule endometriali di pazienti affette da endometriosi, paragonandole ai corrispett...

  19. Myroides odoratimimus soft tissue infection in an immunocompetent child following a pig bite: case report and literature review

    OpenAIRE

    Sofia Maraki; Emmanouela Sarchianaki; Sophia Barbagadakis

    2012-01-01

    Members of the genus Myroides are aerobic Gram-negative bacteria that are common in environmental sources, but are not components of the normal human microflora. Myroides organisms behave as low-grade opportunistic pathogens, causing infections in severely immunocompromised patients and rarely, in immunocompetent hosts. A case of Myroides odoratimimus cellulitis following a pig bite in an immunocompetent child is presented, and the medical literature on Myroides spp. soft tissue infections is...

  20. Exposure and response of human non-neuronal cells to prions in vitro

    OpenAIRE

    Krejciova, Zuzana

    2012-01-01

    Despite intensive research, the cellular and molecular mechanisms involved in human cellular susceptibility to prion infection remain poorly defined, in part due to the continuing lack of cultured human cells that are susceptible to infection with human prions. Such culture models would present distinct advantages including speed and expense compared with animal models, and would provide systems in which to investigate the interaction between PrPC and PrPSc, the basis of cellul...