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Sample records for cellular energetics diet

  1. Computational energetic model of morphogenesis based on multi-agent Cellular Potts Model.

    Science.gov (United States)

    Tripodi, Sébastien; Ballet, Pascal; Rodin, Vincent

    2010-01-01

    The Cellular Potts Model (CPM) is a cellular automaton (CA), developed by Glazier and Graner in 1992, to model the morphogenesis. In this model, the entities are the cells. It has already been improved in many ways; however, a key point in biological systems, not defined in CPM, is energetic exchange between entities. We integrate this energetic concept inside the CPM. We simulate a cell differentiation inside a growing cell tissue. The results are the emergence of dynamic patterns coming from the consumption and production of energy. A model described by CA is less scalable than one described by a multi-agent system (MAS). We have developed a MAS based on the CPM, where a cell agent is implemented from the cell of CPM together with several behaviours, in particular the consumption and production of energy from the consumption of molecules.

  2. Evaluation of cellular energetics by the pasteur effect in intact cardiomyoblasts and isolated perfused hearts.

    Science.gov (United States)

    Muscari, Claudio; Gamberini, Chiara; Bonafe', Francesca; Giordano, Emanuele; Bianchi, Cristina; Lenaz, Giorgio; Caldarera, Claudio Marcello

    2004-03-01

    This work aims at exploring changes in cellular energetics by exploiting the Pasteur effect. We assumed that lactate overproduction arising from antimycin A-induced inhibition of mitochondrial respiration (delta-lactate = stimulated [lactate] -basal [lactate]) is indicative of the energy provided aerobically by the cell. Rat embryonal cardiomyocytes (H9c2), incubated with 2 micromol/L antimycin A, increased about 6 fold their lactate production in a manner linear with time and cell number. Antimycin A was also delivered to Langendorff-perfused rat hearts under control aerobic conditions or after 20 min-ischemia and 30 min-reperfusion. The test started at the end of each perfusion and lactate was measured into perfusate collected for further 25 min. A cardioplegic solution was also delivered during the test to exclude that lactate production was influenced by cardiac contraction. Control delta-lactate was 20.9 +/- 2.31 (S.E.M.) microg/mL and markedly decreased after reperfusion (7.66 +/- 0.51, p < 0.001), showing that energy production was impaired of about 70%. The determination of oxygen consumption by mitochondria isolated from reperfused hearts also suggested that the damage to the respiratory chain was similar to that evaluated by lactate overproduction (Respiratory Control Index: 75% lower than control, p < 0.001). Moreover, when delta-lactate was referred to the estimated cells which remained viable at the end of reperfusion (49.9%), it was 25% lower than control (p < 0.05). Therefore, we proposed this test as a tool for quantifying both physiological and pathological energetic modifications in living intact cardiomyocytes and in isolated and perfused hearts.

  3. High concentrations of H2O2 make aerobic glycolysis energetically more favourable than cellular respiration.

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    Hamid R Molavian

    2016-08-01

    Full Text Available Since the original observation of the Warburg Effect in cancer cells, over eight decades ago, the major question of why aerobic glycolysis is favored over oxidative phosphorylation has remained unresolved. An understanding of this phenomenon may well be the key to the development of more effective cancer therapies. In this paper, we use a semi-empirical method to throw light on this puzzle. We show that aerobic glycolysis is in fact energetically more favorable than oxidative phosphorylation for concentrations of peroxide (H2O2 above some critical threshold value. The fundamental reason for this is the activation and high engagement of the pentose phosphate pathway (PPP in response to the production of reactive oxygen species H2O2 by mitochondria and the high concentration of H2O2 (produced by mitochondria and other sources. This makes oxidative phosphorylation an inefficient source of energy since it leads (despite high levels of ATP production to a concomitant high energy consumption in order to respond to the hazardous waste products resulting from cellular processes associated with this metabolic pathway. We also demonstrate that the high concentration of H2O2 results in an increased glucose consumption, and also increases the lactate production in the case of glycolysis.

  4. A metabolic-transcriptional network links sleep and cellular energetics in the brain.

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    Wisor, Jonathan P

    2012-01-01

    This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.

  5. Correlation of cardiac performance with cellular energetic components in the oxygen-deprived turtle heart

    DEFF Research Database (Denmark)

    Stecyk, Jonathan; Bock, Christian; Overgaard, Johannes;

    2009-01-01

    of an anoxia-tolerant vertebrate, the freshwater turtle (Trachemys scripta) during long-term anoxia exposure ( 3 h at 21°C and 11 days at 5°C). During anoxia, phosphocreatine (PCr), unbound levels of inorganic phosphate (effective Pi2–), intracellular pH (pHi), and free energy of ATP hydrolysis (d......G/d ) exhibited asymptotic patterns of change, indicating that turtle myocardial high-energy phosphate metabolism and energetic state are reset to new, reduced steady states during long-term anoxia exposure. At 21°C, anoxia caused a reduction in pHi from 7.40 to 7.01, a 69% decrease in PCr and a doubling...

  6. Downregulation of cellular protective factors of rumen epithelium in goats fed high energy diet.

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    Manfred Hollmann

    Full Text Available Energy-rich diets can challenge metabolic and protective functions of the rumen epithelial cells, but the underlying factors are unclear. This study sought to evaluate proteomic changes of the rumen epithelium in goats fed a low, medium, or high energy diet. Expression of protein changes were compared by two-dimensional differential gel electrophoresis followed by protein identification with matrix assisted laser desorption ionisation tandem time-of-flight mass spectrometry. Of about 2,000 spots commonly detected in all gels, 64 spots were significantly regulated, which were traced back to 24 unique proteins. Interestingly, the expression profiles of several chaperone proteins with important cellular protective functions such as heat shock cognate 71 kDa protein, peroxiredoxin-6, serpin H1, protein disulfide-isomerase, and selenium-binding protein were collectively downregulated in response to high dietary energy supply. Similar regulation patterns were obtained for some other proteins involved in transport or metabolic functions. In contrast, metabolic enzymes like retinal dehydrogenase 1 and ATP synthase subunit beta, mitochondrial precursor were upregulated in response to high energy diet. Lower expressions of chaperone proteins in the rumen epithelial cells in response to high energy supply may suggest that these cells were less protected against the potentially harmful rumen toxic compounds, which might have consequences for rumen and systemic health. Our findings also suggest that energy-rich diets and the resulting acidotic insult may render rumen epithelial cells more vulnerable to cellular damage by attenuating their cell defense system, hence facilitating the impairment of rumen barrier function, typically observed in energy-rich fed ruminants.

  7. Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo

    NARCIS (Netherlands)

    Abdurrachim, Desiree; Ciapaite, Jolita; Wessels, Bart; Nabben, Miranda; Luiken, Joost J. F. P.; Nicolay, Klaas; Prompers, Jeanine J.

    2014-01-01

    Obesity is often associated with abnormalities in cardiac morphology and function. This study tested the hypothesis that obesity-related cardiomyopathy is caused by impaired cardiac energetics. In a mouse model of high-fat diet (HFD)-induced obesity, we applied in vivo cardiac P-31 magnetic resonanc

  8. Effects of a high lipidic diet on murine energetic reserves in food deprivation.

    Science.gov (United States)

    Cartañà, J; Huget, J; Arola, L; Alemany, M

    1989-11-01

    Female mice were fed for one month either control or cafeteria diets. Then they were subjected to food deprivation for up to 36 hours and their weight loss, tissue lipid, glycogen and protein were determined together with their plasma glycose, amino acids, urea, lipoproteins and ketone bodies. Cafeteria mice were able to cope with prolonged starvation with altered plasma composition and important loss of lipids and protein, sparing to a certain degree their glucose and amino acids. Control-fed mice, however, showed a intense ketosis and significant losses of nitrogen. The results obtained showed a higher ability of cafeteria mice to handle and use lipids, that evolves in a better suitability to resist food deprivation with less extensive alterations in their fuel and nitrogen homeostasis.

  9. Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue.

    Science.gov (United States)

    Ruzickova, Jana; Rossmeisl, Martin; Prazak, Tomas; Flachs, Pavel; Sponarova, Jana; Veck, Marek; Tvrzicka, Eva; Bryhn, Morten; Kopecky, Jan

    2004-12-01

    Omega-3 PUFA of marine origin reduce adiposity in animals fed a high-fat diet. Our aim was to learn whether EPA and DHA could limit development of obesity and reduce cellularity of adipose tissue and whether other dietary FA could influence the effect of EPA/DHA. Weight gain induced by composite high-fat diet in C57BL/6J mice was limited when the content of EPA/DHA was increased from 1 to 12% (wt/wt) of dietary lipids. Accumulation of adipose tissue was reduced, especially of the epididymal fat. Low ratio of EPA to DHA promoted the effect. A higher dose of EPA/DHA was required to reduce adiposity when admixed to diets that did not promote obesity, the semisynthetic high-fat diets rich in EFA, either alpha-linolenic acid (ALA, 18:3 n-3, the precursor of EPA and DHA) or linoleic (18:2 n-6) acid. Quantification of adipose tissue DNA revealed that except for the diet rich in ALA the reduction of epididymal fat was associated with 34-50% depression of tissue cellularity, similar to the 30% caloric restriction in the case of the high-fat composite diet. Changes in plasma markers and adipose gene expression indicated improvement of lipid and glucose metabolism due to EPA/DHA even in the context of the diet rich in ALA. Our results document augmentation of the antiadipogenic effect of EPA/DHA during development of obesity and suggest that EPA/DHA could reduce accumulation of body fat by limiting both hypertrophy and hyperplasia of fat cells. Increased dietary intake of EPA/DHA may be beneficial regardless of the ALA intake.

  10. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans

    DEFF Research Database (Denmark)

    Grau, K; Hansen, Torben; Holst, C;

    2009-01-01

    BACKGROUND: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass. OBJECTIVE: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet...... and whether the effect of the FTO variant depends on dietary fat and CHO content. DESIGN: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20-25% of energy (%E) from fat, 60-65%E from CHO) or HF (40-45%E from fat, 40-45%E from CHO), hypo......-energetic diet (measured resting metabolic rate multiplied by 1.3-600 kcal day(-1)). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-beta) and a surrogate measure of insulin resistance...

  11. Distribution, diet, and energetic condition of age-0 walleye pollock (Gadus chalcogrammus) and pacific cod (Gadus macrocephalus) inhabiting the Gulf of Alaska

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    Moss, Jamal H.; Zaleski, Marilyn F.; Heintz, Ron A.

    2016-10-01

    Walleye pollock (Gadus chalcogrammus) and Pacific cod (Gadus macrocephalus) are commercially and ecologically important species in Alaska waters. Little is known about their ecology after transitioning from larvae to free swimming fish until settlement to nursery habitats in the eastern Gulf of Alaska. Differences in the distribution, diet, body size, and energetic status between the eastern and central Gulf of Alaska were investigated during summer months to better understand regional and interspecific differences in life history and ecology. The composition of zooplankton prey in the diets of walleye pollock and Pacific cod inhabiting shelf waters was more varied relative to those inhabiting the slope and basin. Body condition and total energy content of Pacific cod was greater than walleye pollock, however total energy content increased with length at a similar rate for both species. Walleye pollock inhabiting continental slope waters had higher energy stores relative to those inhabiting the continental shelf and basin, indicating an energetic advantage for individuals remaining off the shelf during summer months or potentially the advection of fish with higher energy reserves off of the shelf. Previous studies have documented the importance of energy stores for surviving winter and future studies should focus on understanding the mechanisms influencing lipid storage and somatic growth for walleye pollock and Pacific cod inhabiting the eastern and central Gulf of Alaska.

  12. Allelic variants of melanocortin 3 receptor gene (MC3R and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

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    José L Santos

    Full Text Available INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets. SUBJECTS AND METHODS: This research is based on the NUGENOB study, a trial conducted to assess weight loss during a 10-week dietary intervention involving two different hypo-energetic (high-fat and low-fat diets. A total of 760 obese patients were genotyped for 10 single nucleotide polymorphisms covering the single exon of MC3R gene and its flanking regions, including the missense variants Thr6Lys and Val81Ile. Linear mixed models and haplotype-based analysis were carried out to assess the potential association between genetic polymorphisms and differential weight loss, fat mass loss, waist change and resting energy expenditure changes. RESULTS: No differences in drop-out rate were found by MC3R genotypes. The rs6014646 polymorphism was significantly associated with weight loss using co-dominant (p = 0.04 and dominant models (p = 0.03. These p-values were not statistically significant after strict control for multiple testing. Haplotype-based multivariate analysis using permutations showed that rs3827103-rs1543873 (p = 0.06, rs6014646-rs6024730 (p = 0.05 and rs3746619-rs3827103 (p = 0.10 displayed near-statistical significant results in relation to weight loss. No other significant associations or gene*diet interactions were detected for weight loss, fat mass loss, waist change and resting energy expenditure changes. CONCLUSION: The study

  13. Diets

    Science.gov (United States)

    ... prevent weight-related diseases, such as heart disease, diabetes, arthritis and some cancers. A healthy diet is an important part of a weight-loss ... you to lose weight. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  14. SNP Identification through Transcriptome Analysis of the European Brown Hare (Lepus europaeus: Cellular Energetics and Mother's Curse.

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    Grigoris D Amoutzias

    Full Text Available The European brown hare (Lepus europaeus, Pallas 1778 is an important small game species in Europe. Due to its size and position in the food chain, as well as its life history, phenotypic variation and the relatively recent speciation events, brown hare plays an important role in the structure of various ecosystems and has emerged as an important species for population management and evolutionary studies. In order to identify informative SNPs for such studies, heart and liver tissues of three samples from the European lineage and a three-sample pool from the Anatolian lineage were subjected to RNA-Sequencing analysis. This effort resulted in 9496 well-assembled protein-coding sequences with close homology to human. After applying very stringent filtering criteria, 66185 polymorphic sites were identified in 7665 genes/cds and 2050 of those polymorphic sites are potentially capable of distinguishing the European from the Anatolian lineage. From these distinguishing mutations we focused on those in genes that are involved in cellular energy production, namely the glycolysis, Krebs cycle and the OXPHOS machinery. A selected set of SNPs was also validated by Sanger sequencing. By simulating the three European individuals as one pool, no substantial informative-SNP identification was lost, making it a cost-efficient approach. To our knowledge this is the first attempt to correlate the differentiation in both nuclear and mitochondrial genome between the two different lineages of L. europaeus with the observed spatial partitioning of the lineages of the species, proposing a possible mechanism that is maintaining the reproductive isolation of the lineages.

  15. Roles of diet protein and temperature in the growth and nutritional energetics of juvenile slider turtles, Trachemys scripta

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    Avery, Harold W.; Spotila, James R.; Congdon, Justin D.; Fischer, Robert U.; Standora, Edward A.; Avery, Susan B.

    1993-01-01

    We determined the effects of dietary protein and Ta on growth rates, food consumption rates, digestion rates, and digestive efficiencies of juvenile slider turtles (Trachemys scripta). Results from this study provide a clearer understanding of how these environmental factors interact in influencing body sizes and growth rates of individuals in wild slider turtle populations. Changes in plastron length, carapace length, and body mass were significantly greater for T. scripta eating 25% and 40% crude protein diets than for those eating 10% crude protein. Those consuming 10% crude protein showed significant decreases in body mass and plastron length over a 13-wk period. Individuals at Ta's of 15°, 22°, 28°, or 34° C had food ingestion rates (kJ wk⁻¹) that increased markedly with an increase in Ta. Increasing dietary crude protein concentration increased turtle ingestion rates and influenced the positive effect of Ta. Increasing dietary crude protein concentration alone did not significantly affect turtle consumption rates but did significantly influence the positive effect of Ta. Digestive efficiencies were very high (because of the pelleted diet). Those turtles that ate at 15° C had a digestive efciency of 99.5%, as compared with 98.3% at 22° C, 94.8% at 28° C, and 95.8% at 34° C. Dietary protein concentration did not influence the digestive efficiencies of T. scripta. These data suggest that dietary protein is an important nutritional component to the growth of juvenile slider turtles and that elevated thermal conditions, combined with a high dietary protein availability, may explain the very high growth rates of slider turtles in some wild populations.

  16. Energetic Systems

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    Federal Laboratory Consortium — The Energetic Systems Division provides full-spectrum energetic engineering services (project management, design, analysis, production support, in-service support,...

  17. Metabolic fate of saturated and monounsaturated dietary fats: the Mediterranean diet revisited from epidemiological evidence to cellular mechanisms.

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    Bergouignan, Audrey; Momken, Iman; Schoeller, Dale A; Simon, Chantal; Blanc, Stéphane

    2009-01-01

    Increasing evidence indicates favourable effects of the Mediterranean diet, partly associated to its monounsaturated fatty acids (MUFA) content on both obesity and diabetes. However, neither the underlying mechanisms by which the Mediterranean diet exerts its protective effect, nor the interplay with other environmental factors (i.e. physical activity), are fully characterised. In this review, we examined recent data on how the metabolic fate of MUFA and saturated fatty acids (SFA) differs. Because of differential packaging into lipoproteins, hydrolysis of triacylglycerol-rich lipoproteins by lipoprotein lipase and transport into oxidative tissues, MUFA are oxidised more than SFA. This high MUFA oxidation favour lipid oxidation and according to the oxidative balance concept reduces the risk of obesity. It also improves the intra-muscular triacylglycerol turnover, which mitigates the SFA-induced accumulation of diacylglycerol and ceramides, and thus protects the insulin sensitivity and cell viability. Finally, physical activity through its action on the energy turnover differentially regulates the metabolism of SFA and MUFA. The putative combined role of AMP-activated kinase and mitochondrial glycerol-3-phosphate transferase on the intra-muscular partitioning of MUFA and SFA provides new areas of research to better understand the beneficial effects of the Mediterranean diet and physical activity on obesity and diabetes.

  18. Energetic values and performace of broilers feeding sorghum and soybean meal based diets supplemented with B-glucanase and B-xylanase

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    Evandro de Abreu Fernandes

    2016-04-01

    Full Text Available Grains, brans, and vegetable meals may contain non-starch polysaccharides (NSP, which increases viscosity in the gastrointestinal tract (GIT and interfere with the digestion and absorption of nutrients. This study aimed to evaluate the performance and determine the metabolizable energy of a sorghum-based broiler diet with and without the supplementation of an enzymatic complex. The experiments were conducted in a completely randomized design with 1200 chickens, using sorghum-based feed with and without the addition of 50 g of enzyme-CCE complex (?-glucanase and ?-xylanase, and with two levels of metabolizable energy (ME kg-1: ME; ME + CCE; reduced ME (-50 kcal kg-1; and reduced ME + CCE. The data were subjected to an analysis of variance and the means were compared using a Tukey’s test at the 5% significance level. At 42 and 47 days of age, the living weight of the birds fed with the reduced ME was low, while birds fed with reduced ME + CCE had the same weight as those fed with other energy diets (ME and ME + CCE. Feed conversion was poorest at 47 days of age for the birds on reduced ME diet. In the metabolic test (with fattening diets to determine AME and AMEn, the reduced ME diet had the lowest result, confirming the effect of the addition of enzymes. The addition of CCE to sorghum-based diets provides enough enzymatic activity to increase the metabolizable energy of the diet (50 kcal of AME and influence the growth performance of broilers at the slaughtering age.

  19. Efeito da redução da densidade energética de dietas sobre as características do ovo de codorna japonesa Effect of energetic density reduction of diets on characteristics of Japanese quail eggs

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    Guilherme de Souza Moura

    2010-06-01

    Full Text Available Objetivou-se avaliar os efeitos da redução da densidade energética da dieta sobre a qualidade de ovo de codornas japonesas, mantendo a mesma relação energia metabolizável (EM:nutrientes. Foram utilizadas 400 codornas japonesas dos 76 aos 160 dias de idade, distribuídas em delineamento inteiramente casualizado, com cinco tratamentos, 10 repetições e 8 aves por unidade experimental. Utilizaram-se cinco dietas com densidades energéticas distintas (2.900, 2.800, 2.700, 2.600 e 2.500 kcal de EM/kg, mantendo constante a relação entre energia metabolizável e nutrientes da dieta, que continha 2.900 kcal de EM/kg. As aves foram arraçoadas à vontade durante todo o período experimental. Houve diferença significativa apenas no consumo de ração e peso no específico de ovo. Para consumo de EM, PB e aminoácidos, peso do ovo, massa do ovo, peso da gema, porcentagem da gema, peso do albúmen, porcentagem do albúmen, peso da casca, porcentagem da casca, diâmetro do ovo e altura do ovo, não foram encontradas diferença significativas entre as dietas. Recomenda-se utilizar dietas com 2.800 e 2.900 kcal de EM/kg, mantendo a mesma relação EM:nutrientes da dieta, quando o objetivo for qualidade de ovo.The aim of this study was to evaluate the effects of reduction of energetic density of the diet on the quality of Japanese quail eggs, keeping the same metabolizable energy (ME:nutrients relationship. It was used 400 Japanese quails from 76 to 160 days of age, distributed in a complete random design, with five treatments, 10 replicates and 8 birds per experimental unity. It was used five diets with different energetic densities (2,900; 2,800; 2,700; 2,600; and 2,500 kcal ME/kg, keeping constant the relationship between metabolizable energy and nutrients of the diet, which had 2,900 kcal ME/kg. Diet was fed ad libitum during all the experimental period. There was a significant difference only on the ration intake and on the egg specific weight

  20. Haematological and immunological adaptations of non-pregnant, non-lactating dairy cows to a high-energetic diet containing mycotoxins.

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    Dänicke, Sven; Meyer, Ulrich; Winkler, Janine; Ulrich, Sebastian; Frahm, Jana; Kersten, Susanne; Valenta, Hana; Rehage, Jürgen; Häussler, Susanne; Sauerwein, Helga; Locher, Lena

    2016-01-01

    Diet change and fatness are supposed to challenge the immune system of the cow. Therefore, immunological and haematological consequences of adaptation to and continued feeding of a high-energy diet were studied in eight non-pregnant, non-lactating Holstein cows over 16 weeks. Blood haptoglobin concentration remained unaltered, suggesting that an acute phase reaction was not induced. Stimulation ability of peripheral blood mononuclear cells and stimulated oxidative burst capacity of granulocytes increased significantly in the course of the experiment after an initial drop. While total leucocyte counts increased, the proportion of granulocytes increased and that of lymphocytes decreased at the same time as the ratio of CD4(+)/CD8(+) lymphocytes did. Capability of rumen microbes to detoxify the immune-modulating mycotoxin deoxynivalenol (DON) was not compromised as indicated by the exclusive presence of de-DON as the detoxified DON metabolite in blood. In conclusion, both diet change and prolonged positive energy balance influenced the bovine immune system.

  1. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights

    Science.gov (United States)

    Sinha-Hikim, Amiya P.; Sinha-Hikim, Indrani; Friedman, Theodore C.

    2017-01-01

    Non-alcoholic fatty liver disease (NAFLD) poses a serious health hazard affecting 20–40% of adults in the general population in the USA and over 70% of the obese and extremely obese people. In addition to obesity, nicotine is recognized as a risk factor for NAFLD, and it has been reported that nicotine can exaggerate obesity-induced hepatic steatosis. The development of NAFLD has serious clinical complications because of its potential progression from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma. Multiple mechanisms can be involved in nicotine plus high-fat diet-induced (HFD) hepatic steatosis. Emerging evidence now suggests that nicotine exacerbates hepatic steatosis triggered by HFD, through increased oxidative stress and hepatocellular apoptosis, decreased phosphorylation (inactivation) of adenosine-5-monophosphate-activated protein kinase and, in turn, up-regulation of sterol response-element binding protein 1-c, fatty acid synthase, and activation of acetyl-coenzyme A-carboxylase, leading to increased hepatic lipogenesis. There is also growing evidence that chronic endoplasmic reticulum stress through regulation of several pathways leading to oxidative stress, inflammation, perturbed hepatic lipid homeostasis, apoptosis, and autophagy can induce hepatic steatosis and its progression to NASH. Evidence also suggests a central role of the gut microbiota in obesity and its related disorders, including NAFLD. This review explores the contribution of nicotine and obesity to the development of NAFLD and its molecular underpinning. PMID:28239368

  2. Energetics Conditioning Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetics Conditioning Facility is used for long term and short term aging studies of energetic materials. The facility has 10 conditioning chambers of which 2...

  3. Bland diet

    Science.gov (United States)

    Heartburn - bland diet; Nausea - bland diet; Diarrhea - bland diet; Peptic ulcer - bland diet ... A bland diet can be used alongside lifestyle changes to help treat ulcers, heartburn, nausea, vomiting, diarrhea, and gas. You may ...

  4. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.

    Science.gov (United States)

    Camporez, João Paulo G; Jornayvaz, François R; Lee, Hui-Young; Kanda, Shoichi; Guigni, Blas A; Kahn, Mario; Samuel, Varman T; Carvalho, Carla R O; Petersen, Kitt Falk; Jurczak, Michael J; Shulman, Gerald I

    2013-03-01

    Estrogen replacement therapy reduces the incidence of type 2 diabetes in postmenopausal women; however, the mechanism is unknown. Therefore, the aim of this study was to evaluate the metabolic effects of estrogen replacement therapy in an experimental model of menopause. At 8 weeks of age, female mice were ovariectomized (OVX) or sham (SHAM) operated, and OVX mice were treated with vehicle (OVX) or estradiol (E2) (OVX+E2). After 4 weeks of high-fat diet feeding, OVX mice had increased body weight and fat mass compared with SHAM and OVX+E2 mice. OVX mice displayed reduced whole-body energy expenditure, as well as impaired glucose tolerance and whole-body insulin resistance. Differences in whole-body insulin sensitivity in OVX compared with SHAM mice were accounted for by impaired muscle insulin sensitivity, whereas both hepatic and muscle insulin sensitivity were impaired in OVX compared with OVX+E2 mice. Muscle diacylglycerol (DAG), content in OVX mice was increased relative to SHAM and OVX+E2 mice. In contrast, E2 treatment prevented the increase in hepatic DAG content observed in both SHAM and OVX mice. Increases in tissue DAG content were associated with increased protein kinase Cε activation in liver of SHAM and OVX mice compared with OVX+E2 and protein kinase Cθ activation in skeletal muscle of OVX mice compared with SHAM and OVX+E2. Taken together, these data demonstrate that E2 plays a pivotal role in the regulation of whole-body energy homeostasis, increasing O(2) consumption and energy expenditure in OVX mice, and in turn preventing diet-induced ectopic lipid (DAG) deposition and hepatic and muscle insulin resistance.

  5. In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets.

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    Joanne S Allard

    Full Text Available Calorie restriction (CR produces several health benefits and increases lifespan in many species. Studies suggest that alternate-day fasting (ADF and exercise can also provide these benefits. Whether CR results in lifespan extension in humans is not known and a direct investigation is not feasible. However, phenotypes observed in CR animals when compared to ad libitum fed (AL animals, including increased stress resistance and changes in protein expression, can be simulated in cells cultured with media supplemented with blood serum from CR and AL animals. Two pilot studies were undertaken to examine the effects of ADF and CR on indicators of health and longevity in humans. In this study, we used sera collected from those studies to culture human hepatoma cells and assessed the effects on growth, stress resistance and gene expression. Cells cultured in serum collected at the end of the dieting period were compared to cells cultured in serum collected at baseline (before the dieting period. Cells cultured in serum from ADF participants, showed a 20% increase in Sirt1 protein which correlated with reduced triglyceride levels. ADF serum also induced a 9% decrease in proliferation and a 25% increase in heat resistance. Cells cultured in serum from CR participants induced an increase in Sirt1 protein levels by 17% and a 30% increase in PGC-1alpha mRNA levels. This first in vitro study utilizing human serum to examine effects on markers of health and longevity in cultured cells resulted in increased stress resistance and an up-regulation of genes proposed to be indicators of increased longevity. The use of this in vitro technique may be helpful for predicting the potential of CR, ADF and other dietary manipulations to affect markers of longevity in humans.

  6. IBS Diet

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    ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ... IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complimentary or Alt Treatments Medications Psychological Treatments ...

  7. Dietas de diferentes densidades energéticas mantendo constante a relação energia metabolizável: nutrientes para codornas japonesas em postura Diets of different energetic densities, keeping constant the metabolizable energy: nutrients ratio, for laying Japanese quails

    Directory of Open Access Journals (Sweden)

    Guilherme de Souza Moura

    2008-09-01

    Full Text Available Objetivou-se avaliar os efeitos da redução da densidade energética das dietas no desempenho de codornas japonesas em produção mantendo-se constante a relação energia metabolizável (EM:nutrientes. Foram utilizadas 400 codornas japonesas com peso inicial de 155 ± 15,5 g e 76 a 160 dias de idade, distribuídas em delineamento inteiramente casualizado, com cinco tratamentos (densidades energéticas: 2.900, 2.800, 2.700, 2.600 e 2.500 kcal de EM/kg, oito repetições e dez aves por unidade experimental. Observou-se diferença no consumo de ração e na conversão alimentar por massa e por dúzia de ovos relacionada ao nível energético da dieta. Entretanto, as dietas não influenciaram os consumos de EM, proteína bruta, lisina, metionina+cistina e treonina, a produção de ovos, a produção de ovos comercializáveis, o peso e a massa de ovo, a eficiência energética por massa de ovo e por dúzia de ovos, o ganho de peso e a viabilidade das aves. Para codornas japonesas em postura, dietas contendo 2.900 e 2.800 kcal de EM/kg proporcionam melhor conversão alimentar por massa e por dúzia de ovos, respectivamente, quando se mantém a relação EM:nutrientes.The aim of this experiment was to evaluate the effects of energetic density reduction in diets in the performance of Japanese quail, keeping constant the metabolizable energy (ME to nutrients ratio. A total of 400 Japanese quails with 155 g ± 5.5 g and 76 to 160 days old were distributes to a complete randomized experimental design with five energetic density, eight replicates and ten birds per experimental unit. Five energetic density in the diets was evaluated (2,900, 2,800, 2,700, 2,600, and 2,500 kcal ME/kg of diet keeping constant the metabolizable energy to nutrients ratio. The birds were fullfed during all experimental period. It was observed difference for feed intake, feed conversion per egg mass and feed conversion per egg dozen related to energy level in the diet. However

  8. Energetics of Si(001)

    NARCIS (Netherlands)

    Zandvliet, H.J.W.

    2000-01-01

    A classical thermodynamic description of a surface requires the introduction of a number of energetic parameters related to the surface steps. These parameters are the step free energy, the kink creation energy, and the energetic and entropic interactions between steps. This review will demonstrate

  9. Inhibition of p38 MAPK during cellular activation modulate gene expression of head kidney leukocytes isolated from Atlantic salmon (Salmo salar) fed soy bean oil or fish oil based diets.

    Science.gov (United States)

    Holen, E; Winterthun, S; Du, Z-Y; Krøvel, A V

    2011-01-01

    Head kidney leukocytes isolated from Atlantic salmon fed either a diet based on fish oil (FO) or soy bean oil (VO) were used in order to evaluate if different lipid sources could contribute to cellular activation of the salmon innate immune system. A specific inhibitor of p38 MAPK, SB202190, was used to investigate the effect of lipopolysaccharide (LPS) signalling in the head kidney leukocytes. The results show that LPS up regulate IL-1β, TNF-α, Cox2 expression in leukocytes isolated from fish fed either diet. The p38 MAPK inhibitor, SB202190, reduced the LPS induced expression of these genes in both dietary groups. In LPS stimulated leukocytes isolated from VO fed fish, SB202190 showed a clear dose dependent inhibitory effect on IL-1β, TNF-α and Cox2 expression. This effect was also observed for Cox2 in leukocytes isolated from FO fed fish. Furthermore, there was a stronger mean induction of Cox2 in LPS stimulated leucocytes isolated from the VO-group compared to LPS stimulated leukocytes isolated from the FO-group. In both dietary groups, LPS stimulation of salmon head kidney leukocytes increased the induction of CD83, a dendrite cell marker, while the inhibitor reduced CD83 expression in the VO fed fish only. The inhibitor also clearly reduced hsp27 expression in VO fed fish. Indicating a p38 MAPK feedback loop, LPS significantly inhibited the expression of p38MAPK itself in both diets, while SB202190 increased p38MAPK expression especially in the VO diet group. hsp70 expression was not affected by any treatment or feed composition. There were also differences in p38MAPK protein phosphorylation comparing treatment groups but no obvious difference comparing the two dietary groups. The results indicate that dietary fatty acids have the ability to modify signalling through p38 MAPK which may have consequences for the fish's ability to handle infections and stress. Signalling through p38MAPK is ligand dependent and affects gene and protein expression differently.

  10. Valor nutritivo do resíduo da indústria processadora de abacaxi (Ananas comosus L. em dietas para ovinos. 1. Consumo, digestibilidade aparente e balanços energético e nitrogenado Nutritive value of pineapple by-product (Ananas comosus L. in diets for sheep. 1. Intake, apparent digestibility, energetic and nitrogenous balance

    Directory of Open Access Journals (Sweden)

    M.C.P. Rogério

    2007-06-01

    Full Text Available O presente estudo foi conduzido para avaliar a influência da inclusão do resíduo do processamento de abacaxi (Ananas comosus L. nas dietas sobre os consumos (por unidade de tamanho metabólico - UTM e coeficientes de digestibilidade da matéria seca (MS, matéria orgânica (MO, proteína bruta (PB, extrato etéreo (EE, fibra detergente neutro (FDN, fibra detergente ácido (FDA, hemiceluloses (HCEL, celulose (CEL e energia de dietas experimentais isofibrosas e isoprotéicas. Avaliaram-se também os balanços nitrogenados e de energia dos animais. Vinte ovinos machos, inteiros receberam rações com quatro níveis de inclusão do resíduo (0; 11%; 16%; 27% em base de matéria seca, em delineamento inteiramente ao acaso, com cinco repetições por tratamento. Maiores consumos de matéria seca foram evidenciados quando as rações continham 11% do resíduo. Maiores consumos de proteína bruta, fibra detergente neutro, fibra detergente ácido e celulose (g/UTM e energia metabolizável (kcal/UTM foram apresentados por animais alimentados com dietas contendo 11% de resíduo em relação ao das dietas com 27% de inclusão (PThe influence of increasing levels of pineapple by-product (Ananas comosus L. on intake (unit metabolic size - UMS and apparent digestibility (% of dry matter (DM, organic matter (OM, crude protein (CP, ether extract (EE, neutral detergent fiber (NDF, acid detergent fiber (ADF, hemicelluloses (HCEL and cellulose (CEL and energy of isofibrous and isoproteic experimental diets of sheep were evaluated. Energetic and nitrogenous balance were also measured. Twenty rams were randomly allotted to four treatments in a completely randomized design with five replications. The treatments were formulated to contain zero; 11, 16 and 27% of pineapple by-product on DM basis. Higher dry matter intake was observed on 11% pineapple by-product diet. CP, NDF, ADF, CEL intake (g/UMS and metabolizable energy intake (kcal/UMS of 11% pineapple by

  11. Solar Energetic Particles

    Science.gov (United States)

    Király, Péter

    Energetic particles recorded in the Earth environment and in interplanetary space have a multitude of origins, i.e. acceleration and propagation histories. At early days practically all sufficiently energetic particles were considered to have come either from solar flares or from interstellar space. Later on, co-rotating interplanetary shocks, the termination shock of the supersonic solar wind, planetary bow shocks and magnetospheres, and also coronal mass ejections (CME) were recognized as energetic particle sources. It was also recognized that less energetic (suprathermal) particles of solar origin and pick-up ions have also a vital role in giving rise to energetic particles in interplanetary disturbances. The meaning of the term "solar energetic particles" (SEP) is now somewhat vague, but essentially it refers to particles produced in disturbances fairly directly related to solar processes. Variation of intensity fluctuations with energy and with the phase of the solar cycle will be discussed. Particular attention will be given to extremes of time variation, i.e. to very quiet periods and to large events. While quiet-time fluxes are expected to shed light on some basic coronal processes, large events dominate the fluctuation characteristics of cumulated fluence, and the change of that fluctuation with energy and with the phase of the solar cycle may also provide important clues. Mainly ISEE-3 and long-term IMP-8 data will be invoked. Energetic and suprathermal particles that may never escape into interplanetary space may play an important part in heating the corona of the sun.

  12. Energetics Laboratory Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — These energetic materials laboratories are equipped with explosion proof hoods with blow out walls for added safety, that are certified for safe handling of primary...

  13. Comparative feeding value of distillers dried grains plus solubles as a partial replacement for steam-flaked corn in diets for calf-fed Holstein steers: characteristics of digestion, growth performance, and dietary energetics.

    Science.gov (United States)

    Carrasco, R; Arrizon, A A; Plascencia, A; Torrentera, N G; Zinn, R A

    2013-04-01

    Two experiments were conducted to examine the effect of level of dried distillers grains plus solubles (DDGS) supplementation (0, 10, 20, and 30%; DM basis), replacing steam-flaked (SF) corn in finishing diets, on characteristics of digestion (Exp. 1) and growth performance (Exp. 2) in calf-fed Holstein steers. In Exp.1, 4 cannulated Holstein steers (349 ± 12 kg) were used to evaluate treatment effects on characteristics of digestion. Ruminal NDF digestion tended to increase (quadratic effect, P = 0.09) and ruminal OM digestion decreased (linear effect, P = 0.01) with DDGS substitution. There were no treatment effects on duodenal flow of microbial N (MN). Substitution with DDGS increased (linear effect, P feeding period), treatment effects on ADG and G:F were small (P ≥ 0.22). Compared with the other treatments, HCW was greater (3.4; P = 0.03) at the 20% level of DDGS substitution. The NE value for DDGS in SF corn-based diets for the calf-fed Holstein are consistent with current tabular standards. Extra-caloric value of DDGS as a metabolizable AA source is apparent during the initial growing phase. The UIP value of DDGS used in this study (35%) was considerably less than current tabular estimates (52%; NRC, 2000).

  14. Paleolithic diet

    OpenAIRE

    Malus, Katja

    2014-01-01

    The paleolithic diet is a diet which imitates the nutrition eaten by various species of hominoids living in the paleolithic era by using foodstuffs available today. The objectives of our thesis were to research the nutrition of human ancestors, to describe a modern paleolithic diet and compare it to healthy dietary guidelines and present experience of individuals who were experimentally eating a paleolithic diet. The aim was to determine whether consuming a paleolithic diet could have benefic...

  15. Cellular automata

    CERN Document Server

    Codd, E F

    1968-01-01

    Cellular Automata presents the fundamental principles of homogeneous cellular systems. This book discusses the possibility of biochemical computers with self-reproducing capability.Organized into eight chapters, this book begins with an overview of some theorems dealing with conditions under which universal computation and construction can be exhibited in cellular spaces. This text then presents a design for a machine embedded in a cellular space or a machine that can compute all computable functions and construct a replica of itself in any accessible and sufficiently large region of t

  16. Vegetarian Diet

    Science.gov (United States)

    A vegetarian diet focuses on plants for food. These include fruits, vegetables, dried beans and peas, grains, seeds and nuts. There is no single type of vegetarian diet. Instead, vegetarian eating patterns usually fall into ...

  17. Diet & Nutrition

    Science.gov (United States)

    ... Nutrition Share this page Facebook Twitter Email Diet & Nutrition Eating healthy to take charge of your health. Shelly Diagnosed in 2006 Diet & Nutrition Take Control of Your Weight Portion Control Low ...

  18. Dense energetic nitraminofurazanes.

    Science.gov (United States)

    Fischer, Dennis; Klapötke, Thomas M; Reymann, Marius; Stierstorfer, Jörg

    2014-05-19

    3,3'-Diamino-4,4'-bifurazane (1), 3,3'-diaminoazo-4,4'-furazane (2), and 3,3'-diaminoazoxy-4,4'-furazane (3) were nitrated in 100 % HNO3 to give corresponding 3,3'-dinitramino-4,4'-bifurazane (4), 3,3'-dinitramino-4,4'-azofurazane (5) and 3,3'-dinitramino-4,4'-azoxyfurazane (6), respectively. The neutral compounds show very imposing explosive performance but possess lower thermal stability and higher sensitivity than hexogen (RDX). More than 40 nitrogen-rich compounds and metal salts were prepared. Most compounds were characterized by low-temperature X-ray diffraction, all of them by infrared and Raman spectroscopy, multinuclear NMR spectroscopy, elemental analysis, and by differential scanning calorimetry (DSC). Calculated energetic performances using the EXPLO5 code based on calculated (CBS-4M) heats of formation and X-ray densities support the high energetic performances of the nitraminofurazanes as energetic materials. The sensitivities towards impact, friction, and electrostatic discharge were also explored. Additionally the general toxicity of the anions against vibrio fischeri, representative for an aquatic microorganism, was determined.

  19. Nonadditive Compositional Curvature Energetics of Lipid Bilayers

    Science.gov (United States)

    Sodt, A. J.; Venable, R. M.; Lyman, E.; Pastor, R. W.

    2016-09-01

    The unique properties of the individual lipids that compose biological membranes together determine the energetics of the surface. The energetics of the surface, in turn, govern the formation of membrane structures and membrane reshaping processes, and thus they will underlie cellular-scale models of viral fusion, vesicle-dependent transport, and lateral organization relevant to signaling. The spontaneous curvature, to the best of our knowledge, is always assumed to be additive. We describe observations from simulations of unexpected nonadditive compositional curvature energetics of two lipids essential to the plasma membrane: sphingomyelin and cholesterol. A model is developed that connects molecular interactions to curvature stress, and which explains the role of local composition. Cholesterol is shown to lower the number of effective Kuhn segments of saturated acyl chains, reducing lateral pressure below the neutral surface of bending and favoring positive curvature. The effect is not observed for unsaturated (flexible) acyl chains. Likewise, hydrogen bonding between sphingomyelin lipids leads to positive curvature, but only at sufficient concentration, below which the lipid prefers negative curvature.

  20. Energetic particle physics

    Institute of Scientific and Technical Information of China (English)

    F. Zonca; G.Y. Fu; S.J. Wang

    2007-01-01

    @@ The confinement properties of energetic (EsslMeV) ions are a crucial aspect of burning plasmas since they are present both as fast particles generated via additional heating and current drive systems as well as charged fusion products. In the first case, successful plasma operations rely on the possibility of controlling plasma current and flow profiles via neutral beam injection (NBI) and plasma temperature profiles by both NBI and ion cyclotron resonant heating (ICRH). In the second case, fusion alpha particles must provide a significant fraction of the local power density, which is ultimately necessary for the sustainment of the plasma burning.

  1. Energetics Manufacturing Technology Center (EMTC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Energetics Manufacturing Technology Center (EMTC), established in 1994 by the Office of Naval Research (ONR) Manufacturing Technology (ManTech) Program, is Navy...

  2. Gout Diet

    Science.gov (United States)

    ... Water Low-fat yogurt 1 cup fresh melon Caffeine-free beverage, such as herbal tea Following a gout diet can help limit uric acid production and increase its elimination. Although the diet isn't likely to lower the uric acid concentration in your blood enough to treat your gout ...

  3. Cellular Telephone

    Institute of Scientific and Technical Information of China (English)

    杨周

    1996-01-01

    Cellular phones, used in automobiles, airliners, and passenger trains, are basically low-power radiotelephones. Calls go through radio transmitters that are located within small geographical units called cells. Because each cell’s signals are too weak to interfere with those of other cells operating on the same fre-

  4. Energetic Causal Sets

    CERN Document Server

    Cortês, Marina

    2013-01-01

    We propose an approach to quantum theory based on the energetic causal sets, introduced in Cort\\^{e}s and Smolin (2013). Fundamental processes are causal sets whose events carry momentum and energy, which are transmitted along causal links and conserved at each event. Fundamentally there are amplitudes for such causal processes, but no space-time. An embedding of the causal processes in an emergent space-time arises only at the semiclassical level. Hence, fundamentally there are no commutation relations, no uncertainty principle and, indeed, no hbar. All that remains of quantum theory is the relationship between the absolute value squared of complex amplitudes and probabilities. Consequently, we find that neither locality, nor non locality, are primary concepts, only causality exists at the fundamental level.

  5. [Diabetes and diet revisited].

    Science.gov (United States)

    Miggiano, G A D; Gagliardi, L

    2006-01-01

    In the treatment of diabetes the diet has an important role complementary to the pharmaceutical treatment. The diet must provide the right amount of nutrients and calories in order for the individual to reach and maintain the ideal weight, stabilize the blood glucose levels close to the norm, and attain an optimal lipid profile. The daily caloric intake is represented by 55-60% of carbohydrates with a preference for nutrients rich in fiber and with a low blood glucose index. Of the daily caloric intake 10% may include sucrose as long as it is consumed in the context of a balanced meal. A moderate use of fructose is allowed, and an increased intake of fiber is encouraged. The consumption of proteins represents about 10-15% of the daily caloric intake. A consumption close to the lower limits of the range (about 0,8 gr/kg of body weight) is required for diabetes patients with nephropathy, while a daily intake of 0,6 gr/kg of body weight is considered to be the malnutrition risk factor for lower levels. The total intake of fats required is or = 100mg/dl and other cardiovascular risk factors), the polyunsaturated fatty acids less than 10%, and the monounsaturated fatty acids at 10-15% of the total caloric intake. The intake of cholesterol through the diet should be high levels of LDL cholesterol. Multivitamin supplements are recommended only for certain categories of diabetic patients that may be at risk of micronutrient deficiency. A moderate quantity of alcohol (5-15 gr/die) is allowed in the case of stabilized diabetes and lack of hypertrigliceridemia. Although the diet may determine a ponderal decrease of up to 10% of the initial weight, it is good to insert a correct nutritional program into a well defined behavioral program that, other than a reduced caloric intake, takes into consideration an increased energetic expenditure through physical activity.

  6. A low-saturated-fat, low-cholesterol diet decreases plasma CETP activity and pre beta-HDL formation but does not affect cellular cholesterol efflux to plasma from type 1 diabetic patients

    NARCIS (Netherlands)

    De Vries, R; Beusekamp, BJ; Kerstens, MN; Groen, AK; Van Tol, A; Dullaart, RPF

    2005-01-01

    The aim of this study was to evaluate the effect of a low-saturated-fat, low-cholesterol diet on plasma lipopoproteins, pre beta-high density lipoprotein (HDL) formation, lecithin: cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP)

  7. Stab Sensitivity of Energetic Nanolaminates

    Energy Technology Data Exchange (ETDEWEB)

    Gash, A; Barbee, T; Cervantes, O

    2006-05-22

    This work details the stab ignition, small-scale safety, and energy release characteristics of bimetallic Al/Ni(V) and Al/Monel energetic nanolaminate freestanding thin films. The influence of the engineered nanostructural features of the energetic multilayers is correlated with both stab initiation and small-scale energetic materials testing results. Structural parameters of the energetic thin films found to be important include the bi-layer period, total thickness of the film, and presence or absence of aluminum coating layers. In general the most sensitive nanolaminates were those that were relatively thick, possessed fine bi-layer periods, and were not coated. Energetic nanolaminates were tested for their stab sensitivity as freestanding continuous parts and as coarse powders. The stab sensitivity of mock M55 detonators loaded with energetic nanolaminate was found to depend strongly upon both the particle size of the material and the configuration of nanolaminate material, in the detonator cup. In these instances stab ignition was observed with input energies as low as 5 mJ for a coarse powder with an average particle dimension of 400 {micro}m. Selected experiments indicate that the reacting nanolaminate can be used to ignite other energetic materials such as sol-gel nanostructured thermite, and conventional thermite that was either coated onto the multilayer substrate or pressed on it. These results demonstrate that energetic nanolaminates can be tuned to have precise and controlled ignition thresholds and can initiate other energetic materials and therefore are viable candidates as lead-free impact initiated igniters or detonators.

  8. Heat release mechanism of energetics

    Energy Technology Data Exchange (ETDEWEB)

    Kubota, N. [Third Research Center, Technical Research and development Institute (Japan)

    1996-12-31

    Determination of the heat release mechanism of energetic materials is a major subject of combustion study. In order to elucidate the combustion process of various types of energetic materials a generalized combustion wave structure was proposed and the heat release process was discussed. The heat release process was significantly different between the physical structures of the materials: homogeneous and heterogeneous materials. The thermal structure of an azide polymer was evaluated to demonstrate the heat release mechanism. (author) 6 refs.

  9. Photodecomposition of energetic nitro compounds

    Energy Technology Data Exchange (ETDEWEB)

    Mialocq, J.C.

    1989-03-14

    The photodecomposition of energetic nitrocompounds depends on the excitation energy, the light intensity which determines the mono-, bi- or multiphotonic character of the initial process and their gaseous, liquid or solid state. The initial processes of the photodecomposition of nitromethane and nitroalcanes are reviewed and their relevance to the initiation of energetic nitrocompounds detonation is discussed. The case of nitramines (dimethylnitramine and tutorial) is also briefly introduced.

  10. [The energetics of obesity].

    Science.gov (United States)

    Bergouignan, Audrey; Blanc, Stéphane

    2006-01-01

    Although there is little argument about the state of energy imbalance that produces weight gain, there is considerable argument about the respective role of genetics, diet and physical activity in achieving obesity. In the USA, obesity has increased in the last decades despite a concomitant decrease in total energy and fat intake suggesting that there has been a dramatic drop in total energy expenditure. In this review, we investigated the respective role of resting metabolic rate, post-prandial thermogenesis, and activity energy expenditure in this lower energy output, and provided evidence that physical inactivity is the major contributor. Based on Jean Mayer original observation (Mayer et al., 1954), we hypothesize that there is a level of physical activity below which mechanisms of body mass regulation are impaired. The increasing prevalence of obesity may reflect the fact the majority of the population has fallen below such a level of physical activity. However, a causal relation between physical inactivity and obesity is still difficult to prove, probably because of the lack of longitudinal models to investigate the physiological consequences of inactivity and because the deleterious consequences of sedentary behaviors are essentially deduced from the benefits of exercise training. By using long term strict bed rest as a unique model of inactivity, we provide evidence that inactivity per se indeed disrupts fuel homeostasis and partitions post-absorptive and post-prandial fat use towards storage, thus promoting weight gain in the long term. More research is needed to investigate mechanisms and to determine the minimal physical activity our body has been engineered for by evolution.

  11. Zeolite synthesis: an energetic perspective.

    Science.gov (United States)

    Zwijnenburg, Martijn A; Bromley, Stefan T

    2010-11-21

    Taking |D(H(2)O)(x)|[AlSiO(4)] based materials (where D is Li, Na, K, Rb or Cs) as an archetypal aluminosilicate system, we use accurate density functional theory calculations to demonstrate how the substitution of silicon cations in silica, with pairs of aluminium and (alkali metal) cations, changes the energetic ordering of different competing structure-types. For large alkali metal cations we further show that the formation of porous aluminosilicate structures, the so-called zeolites, is energetically favored. These findings unequivocally demonstrate that zeolites can be energetic preferred reaction products, rather than being kinetically determined, and that the size of the (hydrated) cations in the pore, be it inorganic or organic, is critical for directing zeolite synthesis.

  12. Helioseismic Effects of Energetic Transients

    Indian Academy of Sciences (India)

    Ashok Ambastha

    2008-03-01

    Photospheric and chromospheric signatures related to large, energetic transients such as flares and CMEs, have been extensively reported during the last several years. In addition, energetic solar transients are expected to cause helioseismic effects. Some of the recent results are reviewed here; in particular, the helioseismic effects of the powerful flares in superactive region, NOAA 10486, including the 4B/X17 superflare of October 28, 2003. We also examine the temporal variations of power in low- modes during the period May 1995–October 2005, and compare with daily, disk-integrated flare- and CME-indices to infer the effect of transients on the scale of whole solar disk.

  13. Sodium in diet

    Science.gov (United States)

    Diet - sodium (salt); Hyponatremia - sodium in diet; Hypernatremia - sodium in diet; Heart failure - sodium in diet ... The body uses sodium to control blood pressure and blood volume. Your body also needs sodium for your muscles and nerves to work ...

  14. Diet and Spondylitis

    Science.gov (United States)

    ... Have Spondylitis? Treatment Information Medications Exercise & Posture Diet & Nutrition Medication & Diet Dietary Supplements Changing Your Diet The London AS / Low Starch Diet Complementary Treatments Possible Complications Iritis or Anterior Uveitis Fatigue in Spondylitis Pain in ...

  15. Diet and Nutrition

    Science.gov (United States)

    ... Resources > Diet and Nutrition Go Back Diet and Nutrition Email Print + Share Diet and nutrition concerns of ... you. NEW!! Test your knowledge of diet and nutrition by taking this self-assessment for an opportunity ...

  16. Mitochondria and Energetic Depression in Cell Pathophysiology

    Directory of Open Access Journals (Sweden)

    Stephan Zierz

    2009-05-01

    Full Text Available Mitochondrial dysfunction is a hallmark of almost all diseases. Acquired or inherited mutations of the mitochondrial genome DNA may give rise to mitochondrial diseases. Another class of disorders, in which mitochondrial impairments are initiated by extramitochondrial factors, includes neurodegenerative diseases and syndromes resulting from typical pathological processes, such as hypoxia/ischemia, inflammation, intoxications, and carcinogenesis. Both classes of diseases lead to cellular energetic depression (CED, which is characterized by decreased cytosolic phosphorylation potential that suppresses the cell’s ability to do work and control the intracellular Ca2+ homeostasis and its redox state. If progressing, CED leads to cell death, whose type is linked to the functional status of the mitochondria. In the case of limited deterioration, when some amounts of ATP can still be generated due to oxidative phosphorylation (OXPHOS, mitochondria launch the apoptotic cell death program by release of cytochrome c. Following pronounced CED, cytoplasmic ATP levels fall below the thresholds required for processing the ATP-dependent apoptotic cascade and the cell dies from necrosis. Both types of death can be grouped together as a mitochondrial cell death (MCD. However, there exist multiple adaptive reactions aimed at protecting cells against CED. In this context, a metabolic shift characterized by suppression of OXPHOS combined with activation of aerobic glycolysis as the main pathway for ATP synthesis (Warburg effect is of central importance. Whereas this type of adaptation is sufficiently effective to avoid CED and to control the cellular redox state, thereby ensuring the cell survival, it also favors the avoidance of apoptotic cell death. This scenario may underlie uncontrolled cellular proliferation and growth, eventually resulting in carcinogenesis.

  17. Energetic materials research using scanning electron microscopy

    NARCIS (Netherlands)

    Elshout, J.J.M.H. van den; Duvalois, W.; Benedetto, G.L. Di; Bouma, R.H.B.; Heijden, A.E.D.M. van der

    2016-01-01

    A key-technique for the research of energetic materials is scanning electron microscopy. In this paper several examples are given of characterization studies on energetic materials, including a solid composite propellant formulation. Results of the characterization of energetic materials using scann

  18. Design of Energetic Ionic Liquids

    Science.gov (United States)

    2011-04-27

    design of energetic ILs, is the application of robust theoretical methods for the reliable prediction of IL heats of formation, synthesis routes, phase... synthesis of the next generation of monopropellants for rocket propulsion applications. 2. Computational Methods An integrated approach...bonded complex between the neutral 1,2,4- triazole and dinitramine molecules, as shown in Figure 1. An ion pair in the presence of a single water

  19. The energetics of bouncing droplets

    Science.gov (United States)

    Turton, Sam; Molacek, Jan; Bush, John

    2016-11-01

    We present the results of a theoretical investigation of the energetics of droplets bouncing on the surface of a vertically vibrating bath. We first assess the relative magnitudes of the kinetic, surface and gravitational potential energies of both the droplet and its wave field. We then seek to rationalize the transitions between the various bouncing and walking states that arise as the vibrational forcing is increased. Our results are compared with prior theoretical and experimental work.

  20. Cardiac energetics: sense and nonsense.

    Science.gov (United States)

    Gibbs, Colin L

    2003-08-01

    1. The background to current ideas in cardiac energetics is outlined and, in the genomic era, the need is stressed for detailed knowledge of mouse heart mechanics and energetics. 2. The mouse heart is clearly different to the rat in terms of its excitation-contraction (EC) coupling and the common assumption that heart rate difference between mice and humans will account for the eightfold difference in myocardial oxygen consumption is wrong, because the energy per beat of the mouse heart is approximately one-third that of the human heart. 3. In vivo evidence suggests that there may well be an eightfold species difference in the non-beating metabolism of mice and human hearts. It is speculated that the magnitude of basal metabolism in the heart is regulatable and that, in the absence of perfusion, it falls to approximately one-quarter of its in vivo rate and that in clinical conditions, such as hibernation, it probably decreases; its magnitude may be controlled by the endothelium. 4. The active energy balance sheet is briefly discussed and it is suggested that the activation heat accounts for 20-25% of the active energy per beat and cross-bridge turnover accounts for the balance. It is argued that force, not shortening, is the major determinant of cardiac energy usage. 5. The outcome of recent cardiac modelling with variants of the Huxley and Hill/Eisenberg models is described. It has been necessary to invoke 'loose coupling' to replicate the low cardiac energy flux measured at low afterloads (medium to high velocities of shortening). 6. Lastly, some of the unexplained or 'nonsense' energetic data are outlined and eight unsolved problems in cardiac energetics are discussed.

  1. Energetic ions in ITER plasmas

    Science.gov (United States)

    Pinches, S. D.; Chapman, I. T.; Lauber, Ph. W.; Oliver, H. J. C.; Sharapov, S. E.; Shinohara, K.; Tani, K.

    2015-02-01

    This paper discusses the behaviour and consequences of the expected populations of energetic ions in ITER plasmas. It begins with a careful analytic and numerical consideration of the stability of Alfvén Eigenmodes in the ITER 15 MA baseline scenario. The stability threshold is determined by balancing the energetic ion drive against the dominant damping mechanisms and it is found that only in the outer half of the plasma ( r / a > 0.5 ) can the fast ions overcome the thermal ion Landau damping. This is in spite of the reduced numbers of alpha-particles and beam ions in this region but means that any Alfvén Eigenmode-induced redistribution is not expected to influence the fusion burn process. The influence of energetic ions upon the main global MHD phenomena expected in ITER's primary operating scenarios, including sawteeth, neoclassical tearing modes and Resistive Wall Modes, is also reviewed. Fast ion losses due to the non-axisymmetric fields arising from the finite number of toroidal field coils, the inclusion of ferromagnetic inserts, the presence of test blanket modules containing ferromagnetic material, and the fields created by the Edge Localised Mode (ELM) control coils in ITER are discussed. The greatest losses and associated heat loads onto the plasma facing components arise due to the use of the ELM control coils and come from neutral beam ions that are ionised in the plasma edge.

  2. Energetic ions in ITER plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Pinches, S. D. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul-lez-Durance Cedex (France); Chapman, I. T.; Sharapov, S. E. [CCFE, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Lauber, Ph. W. [Max-Planck-Institut für Plasmaphysik, EURATOM-Association, Boltzmanstraße 2, D-85748 Garching (Germany); Oliver, H. J. C. [H H Wills Physics Laboratory, University of Bristol, Royal Fort, Tyndall Avenue, Bristol BS8 1TL (United Kingdom); CCFE, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Shinohara, K. [Japan Atomic Energy Agency, Naka, Ibaraki 311-0193 (Japan); Tani, K. [Nippon Advanced Technology Co., Ltd, Naka, Ibaraki 311-0102 (Japan)

    2015-02-15

    This paper discusses the behaviour and consequences of the expected populations of energetic ions in ITER plasmas. It begins with a careful analytic and numerical consideration of the stability of Alfvén Eigenmodes in the ITER 15 MA baseline scenario. The stability threshold is determined by balancing the energetic ion drive against the dominant damping mechanisms and it is found that only in the outer half of the plasma (r/a>0.5) can the fast ions overcome the thermal ion Landau damping. This is in spite of the reduced numbers of alpha-particles and beam ions in this region but means that any Alfvén Eigenmode-induced redistribution is not expected to influence the fusion burn process. The influence of energetic ions upon the main global MHD phenomena expected in ITER's primary operating scenarios, including sawteeth, neoclassical tearing modes and Resistive Wall Modes, is also reviewed. Fast ion losses due to the non-axisymmetric fields arising from the finite number of toroidal field coils, the inclusion of ferromagnetic inserts, the presence of test blanket modules containing ferromagnetic material, and the fields created by the Edge Localised Mode (ELM) control coils in ITER are discussed. The greatest losses and associated heat loads onto the plasma facing components arise due to the use of the ELM control coils and come from neutral beam ions that are ionised in the plasma edge.

  3. Virtual Energetic Particle Observatory (VEPO)

    Science.gov (United States)

    Cooper, John F.; Lal, Nand; McGuire, Robert E.; Szabo, Adam; Narock, Thomas W.; Armstrong, Thomas P.; Manweiler, Jerry W.; Patterson, J. Douglas; Hill, Matthew E.; Vandergriff, Jon D.; McKibben, Robert B.; Lopate, Clifford; Tranquille, Cecil

    2008-01-01

    The Virtual Energetic Particle Observatory (VEPO) focuses on improved discovery, access, and usability of heliospheric energetic particle and ancillary data products from selected spacecraft and sub-orbital instruments of the heliophysics data environment. The energy range of interest extends over the full range of particle acceleration from keV energies of suprathermal seed particles to GeV energies of galactic cosmic ray particles. Present spatial coverage is for operational and legacy spacecraft operating from the inner to the outer heliosphere, e.g. from measurements by the two Helios spacecraft to 0.3 AU to the inner heliosheath region now being traversed by the two Voyager spacecraft. This coverage will eventually be extended inward to ten solar radii by the planned NASA solar probe mission and at the same time beyond the heliopause into the outer heliosheath by continued Voyager operations. The geospace fleet of spacecraft providing near-Earth interplanetary measurements, selected magnetospheric spacecraft providing direct measurements of penetrating interplanetary energetic particles, and interplanetary cruise measurements from planetary spacecraft missions further extend VEPO resources to the domain of geospace and planetary interactions. Ground-based (e.g., neutron monitor) and high-altitude suborbital measurements can expand coverage to the highest energies of galactic cosmic rays affected by heliospheric interaction and of solar energetic particles. Science applications include investigation of solar flare and coronal mass ejection events. acceleration and transport of interplanetary particles within the inner heliosphere, cosmic ray interactions with planetary surfaces and atmospheres, sources of suprathermal and anomalous cosmic ray ions in the outer heliosphere, and solar cycle modulation of galactic cosmic rays. Robotic and human exploration, and eventual habitation, of planetary and space environments beyond the Earth require knowledge of radiation

  4. Nutrition and Diet

    Science.gov (United States)

    ... Thai HbH:Vietnamese Relevant links Living with Thalassemia NUTRITION ▶ Nutrition and DietDiet for the Non-transfused ... Nutrition with Connie Schroepfer, MS, RD: Dec 2016 Nutrition and Diet Nutritional deficiencies are common in thalassemia, ...

  5. Fluoride in diet

    Science.gov (United States)

    Diet - fluoride ... bones and teeth. Too much fluoride in the diet is very rare. Rarely, infants who get too ... of essential vitamins is to eat a balanced diet that contains a variety of foods from the ...

  6. Iodine in diet

    Science.gov (United States)

    Diet - iodine ... Many months of iodine deficiency in a person's diet may cause goiter or hypothyroidism . Without enough iodine, ... and older children. Getting enough iodine in the diet may prevent a form of physical and intellectual ...

  7. Are Detox Diets Safe?

    Science.gov (United States)

    ... A Week of Healthy Breakfasts Shyness Are Detox Diets Safe? KidsHealth > For Teens > Are Detox Diets Safe? ... las dietas de desintoxicación? What Is a Detox Diet? The name sounds reassuring — everyone knows that anything ...

  8. Non-additive compositional curvature energetics of lipid bilayers

    Science.gov (United States)

    Sodt, A.J.; Venable, R.M.; Lyman, E.; Pastor, R.W.

    2016-01-01

    The unique properties of the individual lipids that compose biological membranes together determine the energetics of the surface. The energetics of the surface in turn govern the formation of membrane structures and membrane reshaping processes, and will thus underlie cellular-scale models of viral fusion, vesicle-dependent transport, and lateral organization relevant to signaling. The spontaneous curvature, to the best of our knowledge, is always assumed to be additive. The letter describes observations from simulations of unexpected non-additive compositional curvature energetics of two lipids essential to the plasma membrane: sphingomyelin and cholesterol. A model is developed that connects molecular interactions to curvature stress, and which explains the role of local composition. Cholesterol is shown to lower the number of effective Kuhn segments of saturated acyl chains, reducing lateral pressure below the neutral surface of bending and favoring positive curvature. The effect is not observed for unsaturated (flexible) acyl chains. Likewise, hydrogen bonding between sphingomyelin lipids leads to positive curvature, but only at sufficient concentration, below which the lipid prefers negative curvature. PMID:27715135

  9. Energetic particles in the heliosphere

    CERN Document Server

    Simnett, George M

    2017-01-01

    This monograph traces the development of our understanding of how and where energetic particles are accelerated in the heliosphere and how they may reach the Earth. Detailed data sets are presented which address these topics. The bulk of the observations are from spacecraft in or near the ecliptic plane. It is timely to present this subject now that Voyager-1 has entered the true interstellar medium. Since it seems unlikely that there will be a follow-on to the Voyager programme any time soon, the data we already have regarding the outer heliosphere are not going to be enhanced for at least 40 years.

  10. Nanoporous Silicon Based Energetic Materials

    Science.gov (United States)

    2008-12-01

    performed at SINTEF , Norway as shown in Figure 4 (line a). 3 Annealing PSi in air at different temperatures can be used to change the surface...3h (c)PSi annealed at 500C for 0.5 h (courtesy SINTEF ) e is C d magnification bright field TEM image of PSi-Fe2O3. The inset electron...Dr. Knut Thorshaug and Dr Diplos Spyros of SINTEF Norway for DRIFTS and XPS data. REFERENCES dvanced Energetics Materials, 2004; report byA ring

  11. Active interrogation using energetic protons

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Christopher L [Los Alamos National Laboratory; Chung, Kiwhan [Los Alamos National Laboratory; Greene, Steven J [Los Alamos National Laboratory; Hogan, Gary E [Los Alamos National Laboratory; Makela, Mark [Los Alamos National Laboratory; Mariam, Fesseha [Los Alamos National Laboratory; Milner, Edward C [Los Alamos National Laboratory; Murray, Matthew [Los Alamos National Laboratory; Saunders, Alexander [Los Alamos National Laboratory; Spaulding, Randy [Los Alamos National Laboratory; Wang, Zhehui [Los Alamos National Laboratory; Waters, Laurie [Los Alamos National Laboratory; Wysocki, Frederick [Los Alamos National Laboratory

    2010-01-01

    Energetic proton beams provide an attractive alternative when compared to electromagnetic and neutron beams for active interrogation of nuclear threats because they have large fission cross sections, long mean free paths and high penetration, and they can be manipulated with magnetic optics. We have measured time-dependent cross sections and neutron yields for delayed neutrons and gamma rays using 800 MeV and 4 GeV proton beams with a set of bare and shielded targets. The results show significant signals from both unshielded and shielded nuclear materials. Measurements of neutron energies yield suggest a signature unique to fissile material. Results are presented in this paper.

  12. Niche shifts and energetic condition of songbirds in response to phenology of food-resource availability in a high-elevation sagebrush ecosystem

    Science.gov (United States)

    Cutting, Kyle A.; Anderson, Michelle L.; Beever, Erik; Schroff, Sean; Korb, Nathan; Klaphake, Eric; McWilliams, Scott R.

    2016-01-01

    Seasonal fluctuations in food availability can affect diets of consumers, which in turn may influence the physiological state of individuals and shape intra- and inter-specific patterns of resource use. High-elevation ecosystems often exhibit a pronounced seasonal “pulse” in productivity, although few studies document how resource use and energetic condition by avian consumers change in relation to food-resource availability in these ecosystems. We tested the hypothesis that seasonal increases (pulses) in food resources in high-elevation sagebrush ecosystems result in 2 changes after the pulse, relative to the before-pulse period: (1) reduced diet breadth of, and overlap between, 2 sympatric sparrow species; and (2) enhanced energetic condition in both species. We tracked breeding-season diets using stable isotopes and energetic condition using plasma metabolites of Brewer's Sparrows (Spizella breweri), Vesper Sparrows (Pooecetes gramineus), and their food resources during 2011, and of only Brewer's Sparrows and their food resources during 2013. We quantify diet breadth and overlap between both species, along with coincident physiological consequences of temporal changes in resource use. After invertebrate biomass increased following periods of rainfall in 2011, dietary breadth decreased by 35% in Brewer's Sparrows and by 48% in Vesper Sparrows, while dietary overlap decreased by 88%. Energetic condition of both species increased when dietary overlap was lower and diet breadth decreased, after the rapid rise of food-resource availability. However, energetic condition of Brewer's Sparrows remained constant in 2013, a year with low precipitation and lack of a strong pulse in food resources, even though the species' dietary breadth again decreased that year. Our results indicate that diet breadth and overlap in these sparrow species inhabiting sagebrush ecosystems generally varied as predicted in relation to intra- and interannual changes in food resources, and

  13. Hosting anions. The energetic perspective.

    Science.gov (United States)

    Schmidtchen, Franz P

    2010-10-01

    Hosting anions addresses the widely spread molecular recognition event of negatively charged species by dedicated organic compounds in condensed phases at equilibrium. The experimentally accessible energetic features comprise the entire system including the solvent, any buffers, background electrolytes or other components introduced for e.g. analysis. The deconvolution of all these interaction types and their dependence on subtle structural variation is required to arrive at a structure-energy correlation that may serve as a guide in receptor construction. The focus on direct host-guest interactions (lock-and-key complementarity) that have dominated the binding concepts of artificial receptors in the past must be widened in order to account for entropic contributions which constitute very significant fractions of the total free energy of interaction. Including entropy necessarily addresses the ambiguity and fuzziness of the host-guest structural ensemble and requires the appreciation of the fact that most liquid phases possess distinct structures of their own. Apparently, it is the perturbation of the intrinsic solvent structure occurring upon association that rules ion binding in polar media where ions are soluble and abundant. Rather than specifying peculiar structural elements useful in anion binding this critical review attempts an illumination of the concepts and individual energetic contributions resulting in the final observation of specific anion recognition (95 references).

  14. The New Nordic Diet

    DEFF Research Database (Denmark)

    Salomo, Louise; Poulsen, Sanne Kellebjerg; Rix, Marianne

    2016-01-01

    PURPOSE: High phosphorus content in the diet may have adverse effect on cardiovascular health. We investigated whether the New Nordic Diet (NND), based mainly on local, organic and less processed food and large amounts of fruit, vegetables, wholegrain and fish, versus an Average Danish Diet (ADD...... modifications of the diet are needed in order to make this food concept beneficial regarding phosphorus absorption....

  15. Energetic materials and methods of tailoring electrostatic discharge sensitivity of energetic materials

    Energy Technology Data Exchange (ETDEWEB)

    Daniels, Michael A.; Heaps, Ronald J.; Wallace, Ronald S.; Pantoya, Michelle L.; Collins, Eric S.

    2016-11-01

    An energetic material comprising an elemental fuel, an oxidizer or other element, and a carbon nanofiller or carbon fiber rods, where the carbon nanofiller or carbon fiber rods are substantially homogeneously dispersed in the energetic material. Methods of tailoring the electrostatic discharge sensitivity of an energetic material are also disclosed.

  16. The energetics of nut consumption.

    Science.gov (United States)

    Mattes, Richard D

    2008-01-01

    Nuts are a nutrient-rich food group. Depending on the type, they may provide substantive concentrations of Vitamin E, magnesium, folate, essential fatty acids, fiber and protein to the diet. They also contain potentially important phytochemicals. By mechanisms yet to be identified, they are reported to improve postprandial lipid profiles and may hold other health benefits. However, they are also energy dense so a theoretical contributor to positive energy balance and weight gain. However, epidemiological studies have consistently revealed an inverse association between the frequency of nut consumption and BMI. Further, intervention trials demonstrate less than predicted weight gain following inclusion of nuts in the diet. The mechanisms for these observations are currently under study. Candidates include strong satiety effects, promotion of energy expenditure and/or inefficient energy utilization. Recent trials have revealed support for each. Inclusion of nuts in the diet results in strong satiety effects as revealed by robust compensatory dietary responses that offset approximately 65-75% of the energy they provide. Several trials note increased energy expenditure that may account for an additional 10% of their energy yield. Limited bioaccessibility results in a loss of 5-15% of energy. Taken together, these findings largely account for the energy provided by nuts and explain the epidemiological and clinical observations. Thus, current knowledge suggests moderate nut consumption does not pose a threat for weight gain.

  17. Cosmic Ray Energetics and Mass

    CERN Document Server

    Baylon cardiel, J L; Wallace, K C; Anderson, T B; Copley, M

    The cosmic-ray energetics and mass (CREAM) investigation is designed to measure cosmic-ray composition to the supernova energy scale of 10$^{15}$ eV in a series of ultra long duration balloon (ULDB) flights. The first flight is planned to be launched from Antarctica in December 2004. The goal is to observe cosmic-ray spectral features and/or abundance changes that might signify a limit to supernova acceleration. The particle ($\\{Z}$) measurements will be made with a timing-based charge detector and a pixelated silicon charge detector to minimize the effect of backscatter from the calorimeter. The particle energy measurements will be made with a transition radiation detector (TRD) for $\\{Z}$ > 3 and a sampling tungsten/scintillator calorimeter for $\\{Z}$ $\\geq$1 particles, allowing inflight cross calibration of the two detectors. The status of the payload construction and flight preparation are reported in this paper.

  18. Energetics and the immune system

    Science.gov (United States)

    Reiches, Meredith W.; Prentice, Andrew M.; Moore, Sophie E.; Ellison, Peter T.

    2017-01-01

    Abstract Background and objectives: The human immune system is an ever-changing composition of innumerable cells and proteins, continually ready to respond to pathogens or insults. The cost of maintaining this state of immunological readiness is rarely considered. In this paper we aim to discern a cost to non-acute immune function by investigating how low levels of C-reactive protein (CRP) relate to other energetic demands and resources in adolescent Gambian girls. Methodology: Data from a longitudinal study of 66 adolescent girls was used to test hypotheses around investment in immune function. Non-acute (under 2 mg/L) CRP was used as an index of immune function. Predictor variables include linear height velocity, adiposity, leptin, and measures of energy balance. Results: Non-acute log CRP was positively associated with adiposity (β = 0.16, P resources and demands. We also find support for an adaptive association between the immune system and adipose tissue. PMID:28003312

  19. Energetic model of metal hardening

    Directory of Open Access Journals (Sweden)

    Ignatova O.N.

    2011-01-01

    Full Text Available Based on Bailey hypothesis on the link between strain hardening and elastic lattice defect energy this paper suggests a shear strength energetic model that takes into consideration plastic strain intensity and rate as well as softening related to temperature annealing and dislocation annihilation. Metal strain hardening was demonstrated to be determined only by elastic strain energy related to the energy of accumulated defects. It is anticipated that accumulation of the elastic energy of defects is governed by plastic work. The suggested model has a reasonable agreement with the available experimental data for copper up to P = 70 GPa , for aluminum up to P = 10 GPa and for tantalum up to P = 20 GPa.

  20. Destruction of Energetic Materials in Supercritical Water

    Science.gov (United States)

    2002-06-25

    THERMOCHEMISTRY OF ENERGETIC MATERIALS IN SUPERCRITICAL WATER...fringe spacing is 13.5 µm and the acoustic signal period is 28.3 ns. 138 SECTION VI THERMOCHEMISTRY OF ENERGETIC MATERIALS IN...validation calculation studied the solvation free energies of alkali–chloride ion pairs in liquid water. Such information can teach us about the

  1. Flat Cellular (UMTS) Networks

    NARCIS (Netherlands)

    Bosch, H.G.P.; Samuel, L.G.; Mullender, S.J.; Polakos, P.; Rittenhouse, G.

    2007-01-01

    Traditionally, cellular systems have been built in a hierarchical manner: many specialized cellular access network elements that collectively form a hierarchical cellular system. When 2G and later 3G systems were designed there was a good reason to make system hierarchical: from a cost-perspective i

  2. Creatine, energetic function, metabolism and supplementation effects on sports

    Directory of Open Access Journals (Sweden)

    Emerson Gimenes Bernardo da Silva

    2008-06-01

    Full Text Available The purpose of this work is to review the literature regarding creatine ingestion by athletes and physical activity enthusiasts, discussing its necessity and, if possible, predicting some consequences. In order to achieve this purpose it was necessary to study the relationship between the muscles energetic system and their regulation. It was also proved necessary to investigate the creatine cycle, its endogenous origin, its metabolizing and conversion into creatine-phosphate. A bibliography was used to collect information about the subject. The research lead to the following conclusions: diet supplementation with creatine leads to increased phosphocreatine levels in human muscles. However, new in vivo experiments are most desirable, because it is already known that creatine interferes with the regulation of some metabolic pathways.

  3. Interchange mode excited by trapped energetic ions

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Seiya, E-mail: n-seiya@kobe-kosen.ac.jp [Kobe City College of Technology, Kobe, Hyogo 651-2194 (Japan)

    2015-07-15

    The kinetic energy principle describing the interaction between ideal magnetohydrodynamic (MHD) modes with trapped energetic ions is revised. A model is proposed on the basis of the reduced ideal MHD equations for background plasmas and the bounce-averaged drift-kinetic equation for trapped energetic ions. The model is applicable to large-aspect-ratio toroidal devices. Specifically, the effect of trapped energetic ions on the interchange mode in helical systems is analyzed. Results show that the interchange mode is excited by trapped energetic ions, even if the equilibrium states are stable to the ideal interchange mode. The energetic-ion-induced branch of the interchange mode might be associated with the fishbone mode in helical systems.

  4. Femtosecond Laser Interaction with Energetic Materials

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E; Benterou, J; Lee, R; Roeske, F; Stuart, B

    2002-03-25

    Femtosecond laser ablation shows promise in machining energetic materials into desired shapes with minimal thermal and mechanical effects to the remaining material. We will discuss the physical effects associated with machining energetic materials and assemblies containing energetic materials, based on experimental results. Interaction of ultra-short laser pulses with matter will produce high temperature plasma at high-pressure which results in the ablation of material. In the case of energetic material, which includes high explosives, propellants and pyrotechnics, this ablation process must be accomplished without coupling energy into the energetic material. Experiments were conducted in order to characterize and better understand the phenomena of femtosecond laser pulse ablation on a variety of explosives and propellants. Experimental data will be presented for laser fluence thresholds, machining rates, cutting depths and surface quality of the cuts.

  5. Observations and Modeling of Geospace Energetic Particles

    Science.gov (United States)

    Li, Xinlin

    2016-07-01

    Comprehensive measurements of energetic particles and electric and magnetic fields from state-of-art instruments onboard Van Allen Probes, in a geo-transfer-like orbit, revealed new features of the energetic particles and the fields in the inner magnetosphere and impose new challenges to any quantitative modeling of the physical processes responsible for these observations. Concurrent measurements of energetic particles by satellites in highly inclined low Earth orbits and plasma and fields by satellites in farther distances in the magnetospheres and in the up stream solar wind are the critically needed information for quantitative modeling and for leading to eventual accurate forecast of the variations of the energetic particles in the magnetosphere. In this presentation, emphasis will be on the most recent advance in our understanding of the energetic particles in the magnetosphere and the missing links for significantly advance in our modeling and forecasting capabilities.

  6. Solar impulsive energetic electron events

    Science.gov (United States)

    Wang, Linghua

    The Sun is capable of accelerating ions from ~ tens of keV up to tens of GeV and electrons from ~ tens of eV up to hundreds of MeVs in transient events such as flares and fast coronal mass ejections (CMEs). The energized particles escaping into the interplanetary medium are referred to as Solar Energetic Particle (SEP) events. The great majority of SEP events are impulsive SEP events that are dominated by ~1-100 keV electrons and ~MeV/nucleon ion emissions, with enhanced 3 He/ 4 He ratios up to 10 4 times the coronal values (also called electron/ 3 He-rich SEP events). This thesis is focused on solar impulsive energetic electron events, the electron part of impulsive SEP events, using electron observations from the 3-D Plasma and Energetic Particle instrument (3DP) on the WIND spacecraft near the Earth. First, I present the first comprehensive statistical study of solar energetic electron events over almost one solar cycle. I find that the occurrence rate of solar electron events shows a strong solar-cycle variation; after correction for the background effect, the estimated occurrence frequency exhibits a good power-law distribution, and the estimated occurrence rate near the Earth is ~1000/year at solar maximum and ~30/year at solar minimum for the instrumental sensitivity (~2.9×10^-4 (cm 2 s str eV) -1 for the 40 keV channel) of WIND/3DP, about one order of magnitude larger than the observed occurrence rate. Solar energetic electron events have a one-to-one association with type III radio bursts and a poor association with flares, but a close association with 3 He- rich ion emissions. These 3 He-rich electron events also have a poor association with flares but a close (~ 60%) association with west-limb CMEs. Then I present two case studies: one investigating the temporal relationship between solar impulsive electrons and type III radio emissions, and the second studying the temporal relationship between solar impulsive electrons and 3 He- rich ions. For both

  7. Global Energetics of Solar Flares: IV. Coronal Mass Ejection Energetics

    CERN Document Server

    Aschwanden, Markus J

    2016-01-01

    This study entails the fourth part of a global flare energetics project, in which the mass $m_{\\mathrm{cme}}$, kinetic energy $E_{\\mathrm{kin}}$, and the gravitational potential energy $E_{\\mathrm{grav}}$ of coronal mass ejections (CMEs) is measured in 399 M and X-class flare events observed during the first 3.5 yrs of the Solar Dynamics Observatory (SDO) mission, using a new method based on the EUV dimming effect. The EUV dimming is modeled in terms of a radial adiabatic expansion process, which is fitted to the observed evolution of the total emission measure of the CME source region. The model derives the evolution of the mean electron density, the emission measure, the bulk plasma expansion velocity, the mass, and the energy in the CME source region. The EUV dimming method is truly complementary to the Thomson scattering method in white light, which probes the CME evolution in the heliosphere at $r > 2 R_{\\odot}$, while the EUV dimming method tracks the CME launch in the corona. We compare the CME paramet...

  8. Fundamental Limits to Cellular Sensing

    Science.gov (United States)

    ten Wolde, Pieter Rein; Becker, Nils B.; Ouldridge, Thomas E.; Mugler, Andrew

    2016-03-01

    In recent years experiments have demonstrated that living cells can measure low chemical concentrations with high precision, and much progress has been made in understanding what sets the fundamental limit to the precision of chemical sensing. Chemical concentration measurements start with the binding of ligand molecules to receptor proteins, which is an inherently noisy process, especially at low concentrations. The signaling networks that transmit the information on the ligand concentration from the receptors into the cell have to filter this receptor input noise as much as possible. These networks, however, are also intrinsically stochastic in nature, which means that they will also add noise to the transmitted signal. In this review, we will first discuss how the diffusive transport and binding of ligand to the receptor sets the receptor correlation time, which is the timescale over which fluctuations in the state of the receptor, arising from the stochastic receptor-ligand binding, decay. We then describe how downstream signaling pathways integrate these receptor-state fluctuations, and how the number of receptors, the receptor correlation time, and the effective integration time set by the downstream network, together impose a fundamental limit on the precision of sensing. We then discuss how cells can remove the receptor input noise while simultaneously suppressing the intrinsic noise in the signaling network. We describe why this mechanism of time integration requires three classes (groups) of resources—receptors and their integration time, readout molecules, energy—and how each resource class sets a fundamental sensing limit. We also briefly discuss the scheme of maximum-likelihood estimation, the role of receptor cooperativity, and how cellular copy protocols differ from canonical copy protocols typically considered in the computational literature, explaining why cellular sensing systems can never reach the Landauer limit on the optimal trade

  9. Adaptation to divergent larval diets in the medfly, Ceratitis capitata.

    Science.gov (United States)

    Leftwich, Philip T; Nash, William J; Friend, Lucy A; Chapman, Tracey

    2017-02-01

    Variation in diet can influence the timing of major life-history events and can drive population diversification and ultimately speciation. Proximate responses of life histories to diet have been well studied. However, there are scant experimental data on how organisms adapt to divergent diets over the longer term. We focused on this omission by testing the responses of a global pest, the Mediterranean fruitfly, to divergent selection on larval diets of different nutritional profiles. Tests conducted before and after 30 generations of nutritional selection revealed a complex interplay between the effects of novel larval dietary conditions on both plastic and evolved responses. There were proximate-only responses to the larval diet in adult male courtship and the frequency of copulation. Males on higher calorie larval diets consistently engaged in more bouts of energetic courtship. In contrast, following selection, larval development time, and egg to adult survival showed evidence of evolved divergence between diet regimes. Adult body size showed evidence for adaptation, with flies being significantly heavier when reared on their "own" diet. The results show the multifaceted responses of individuals to dietary selection and are important in understanding the extreme generalism exhibited by the medfly.

  10. Numerical Analyses of Energetic Particles in LHD

    Energy Technology Data Exchange (ETDEWEB)

    Todo, Yasushi [National Institute for Fusion Science, Toki, Japan; Murakami, S. [Kyoto University, Japan; Yamamoto, T. [Kyoto University, Japan; Fukuyama, A. [Kyoto University, Japan; Spong, Donald A [ORNL; Yamamoto, S. [Nagoya University, Japan; Osakabe, M. [National Institute for Fusion Science, Toki, Japan; Nakajima, N. [National Institute for Fusion Science, Toki, Japan

    2010-01-01

    The confinement of energetic ions generated by neutral beam injection (NBI) and ion cyclotron resonance frequency heating is studied using GNET simulation code, in which the drift kinetic equation is solved in five-dimensional phase-space. The steady-state distributions of the energetic ions are obtained, and characteristics of the energetic-ion distribution depending on the plasma heating method are shown. The magnetic configuration effect on the energetic-ion confinement is also investigated, and it is found that the energetic-ion confinement is improved by a strong inward shift of the magnetic axis position in the major radius direction. The interaction between energetic particles and Alfven eigenmodes are investigated using the MEGA code and the AE3D code. A reduced version of the MEGA code has been developed to simulate the Alfven eigenmode (AE) evolution in the Large Helical Device (LHD) plasma with NBI and collisions taken into account. The spatial profile and frequency of the AE modes in the LHD plasma are analyzed with the AE3D code. The evolution of energetic particles and AE mode amplitude and phase are followed in a self-consistent way, while the AE spatial profiles are assumed to be constant. It is demonstrated that the AE bursts can be simulated with the new code.

  11. Diet - chronic kidney disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002442.htm Diet - chronic kidney disease To use the sharing features on this page, ... make changes to your diet when you have chronic kidney disease. These changes may include limiting fluids, eating a ...

  12. Diet and Nutrition

    Science.gov (United States)

    ... need to know about Wilson Disease Diet and Nutrition Food . . . . Adherence to a low copper diet is ... dysarthria; rigid dystonia; pseudobulbar palsy; seizures; migraine headaches; insomnia Psychiatric: Depression; neuroses; personality changes; psychosis Other symptoms: ...

  13. Ketogenic diet and astrocyte/neuron metabolic interactions

    Directory of Open Access Journals (Sweden)

    Vamecq Joseph

    2007-05-01

    Full Text Available The ketogenic diet is an anticonvulsant diet enriched in fat. It provides the body with a minimal protein requirement and a restricted carbohydrate supply, the vast majority of calories (more than 80-90% being given by fat. Though anticonvulsant activity of ketogenic diet has been well documented by a large number of experimental and clinical studies, underlying mechanisms still remain partially unclear. Astrocyte-neuron interactions, among which metabolic shuttles, may influence synaptic activity and hence anticonvulsant protection. The astrocyte-neuron metabolic shuttles may be themselves influenced by the availability in energetic substrates such as hydrates of carbon and fats. Historically, ketogenic diet had been designed to mimic changes such as ketosis occurring upon starvation, a physiological state already known to exhibit anticonvulsant protection and sometimes referred to as “water diet”. For this reason, a special attention should be paid to metabolic features shared in common by ketogenic diet and starvation and especially those features that might result in anticonvulsant protection. Compared to feeding by usual mixed diet, starvation and ketogenic diet are both characterised by increased fat, lowered glucose and aminoacid supplies to cells. The resulting impact of these changes in energetic substrates on astrocyte/neuron metabolic shuttles might have anticonvulsant and/or neuroprotective properties. This is the aim of this communication to review some important astrocyte/neuron metabolic interactions (astrocyte/neuron lactate shuttle, glutamateinduced astrocytic glycolysis activation, glutamate/glutamine cycle along with the neurovascular coupling and the extent to which the way of their alteration by starvation and/or ketogenic diet might result in seizure and/or brain protection.

  14. Ketogenic Diets and Pain

    OpenAIRE

    Masino, Susan A.; Ruskin, David N.

    2013-01-01

    Ketogenic diets are well-established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.

  15. p66shc's role as an essential mitophaghic molecule in controlling neuronal redox and energetic tone

    OpenAIRE

    Kleman, Amy M.; Brown, Jacquelynn E.; Zeiger, Stephanie L.H.; Hettinger, Jane C.; Brooks, Joshua D.; Holt, Benjamin; Morrow, Jason D.; Musiek, Erik S.; Milne, Ginger L.; McLaughlin, BethAnn

    2010-01-01

    Stroke is the leading cause of adult disability in the U.S. and is now recognized as a global epidemic. There are currently no FDA-approved drugs to block the cell death that results from oxygen and glucose deprivation. This void in clinical medicine has sparked an intense interest in understanding endogenous cellular protective pathways that might be exploited for therapeutic development. The work highlighted here describes the critical role between redox tone and energetic stress signaling ...

  16. Diet induced thermogenesis

    NARCIS (Netherlands)

    Westerterp, K.R.

    2004-01-01

    OBJECTIVE: Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and characteristics of the diet. METHODS: Measuring c

  17. High blood pressure and diet

    Science.gov (United States)

    ... increase the potassium in your diet or use salt substitutes (which often contain potassium). People who have kidney ... consume. Alternative Names Hypertension - diet Images DASH diet Low sodium diet References American Heart Association Nutrition Committee; Lichtenstein ...

  18. Global Positioning System (GPS) Energetic Particle Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Energetic particle data from the CXD and BDD instrument on the GPS constellation are available to the space weather research community. The release of these data...

  19. Energetic salt of trinitrophloroglucinol and melamine

    Science.gov (United States)

    Bowden, Patrick R.; Leonard, Philip W.; Lichthardt, Joseph P.; Tappan, Bryce C.; Ramos, Kyle J.

    2017-01-01

    We hope to harness the field of energetic co-crystals for development of insensitive, high-performing explosives. As demonstrated by other groups, co-crystals of energetic materials are diverse in their resultant properties versus the native materials. Herein, we discuss the synthesis, characterization, and testing of an energetic co-crystal of trinitrophloroglucinol (1,3,5-trihydroxy-2,4,6-trinitrobenzene) and melamine. Although melamine is not an energetic material, high nitrogen content and insensitivity can be of benefit in a co-crystal. Currently, trinitrophloroglucinol (TNPG) and melamine have been found to exist as a 1:1 ionic co-crystal. Characterization by NMR, IR, small-scale sensitivity, thermal stability and powder X-ray diffraction have all been used to characterize the individual compounds as well as the co-crystals developed.

  20. Membranes, energetics, and evolution across the prokaryote-eukaryote divide

    Science.gov (United States)

    Lynch, Michael; Marinov, Georgi K

    2017-01-01

    The evolution of the eukaryotic cell marked a profound moment in Earth’s history, with most of the visible biota coming to rely on intracellular membrane-bound organelles. It has been suggested that this evolutionary transition was critically dependent on the movement of ATP synthesis from the cell surface to mitochondrial membranes and the resultant boost to the energetic capacity of eukaryotic cells. However, contrary to this hypothesis, numerous lines of evidence suggest that eukaryotes are no more bioenergetically efficient than prokaryotes. Thus, although the origin of the mitochondrion was a key event in evolutionary history, there is no reason to think membrane bioenergetics played a direct, causal role in the transition from prokaryotes to eukaryotes and the subsequent explosive diversification of cellular and organismal complexity. DOI: http://dx.doi.org/10.7554/eLife.20437.001 PMID:28300533

  1. Energetics based spike generation of a single neuron: simulation results and analysis

    Directory of Open Access Journals (Sweden)

    Nagarajan eVenkateswaran

    2012-02-01

    Full Text Available Existing current based models that capture spike activity, though useful in studying information processing capabilities of neurons, fail to throw light on their internal functioning. It is imperative to develop a model that captures the spike train of a neuron as a function of its intra cellular parameters for non-invasive diagnosis of diseased neurons. This is the first ever article to present such an integrated model that quantifies the inter-dependency between spike activity and intra cellular energetics. The generated spike trains from our integrated model will throw greater light on the intra-cellular energetics than existing current models. Now, an abnormality in the spike of a diseased neuron can be linked and hence effectively analyzed at the energetics level. The spectral analysis of the generated spike trains in a time-frequency domain will help identify abnormalities in the internals of a neuron. As a case study, the parameters of our model are tuned for Alzheimer disease and its resultant spike trains are studied and presented.

  2. Cyanuric Acid/Epichlorohydrin Energetic Prepolymers

    OpenAIRE

    Pedroso, Luís M.; Simões, Pedro; Portugal, António

    2005-01-01

    In this work new energetic prepolymers are synthesised and characterised. The structure of the prepolymers exhibits the 1,3,5-s-triazine ring with lateral chains derived from the epichlorohydrin ring opening. The chlorine atoms in these precursors are here substituted by azido groups. The presence of these groups was confirmed by FTIR and 1H NMR spectroscopy and elemental and thermal analysis. OH group content in the energetic prepolymers was found slightly lower than expected having in view ...

  3. Theoretical studies on nitrogen rich energetic azoles.

    Science.gov (United States)

    Ghule, Vikas Dasharath; Sarangapani, Radhakrishnan; Jadhav, Pandurang M; Tewari, Surya P

    2011-06-01

    Different nitro azole isomers based on five membered heterocyclics were designed and investigated using computational techniques in order to find out the comprehensive relationships between structure and performances of these high nitrogen compounds. Electronic structure of the molecules have been calculated using density functional theory (DFT) and the heat of formation has been calculated using the isodesmic reaction approach at B3LYP/6-31G* level. All designed compounds show high positive heat of formation due to the high nitrogen content and energetic nitro groups. The crystal densities of these energetic azoles have been predicted with different force fields. All the energetic azoles show densities higher than 1.87 g/cm(3). Detonation properties of energetic azoles are evaluated by using Kamlet-Jacobs equation based on the calculated densities and heat of formations. It is found that energetic azoles show detonation velocity about 9.0 km/s, and detonation pressure of 40GPa. Stability of the designed compounds has been predicted by evaluating the bond dissociation energy of the weakest C-NO(2) bond. The aromaticity using nucleus independent chemical shift (NICS) is also explored to predict the stability via delocalization of the π-electrons. Charge on the nitro group is used to assess the impact sensitivity in the present study. Overall, the study implies that all energetic azoles are found to be stable and expected to be the novel candidates of high energy density materials (HEDMs).

  4. Diet induced thermogenesis

    Directory of Open Access Journals (Sweden)

    Westerterp KR

    2004-08-01

    Full Text Available Objective Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and characteristics of the diet. Methods Measuring conditions include nutritional status of the subject, physical activity and duration of the observation. Diet characteristics are energy content and macronutrient composition. Results Most studies measure diet-induced thermogenesis as the increase in energy expenditure above basal metabolic rate. Generally, the hierarchy in macronutrient oxidation in the postprandial state is reflected similarly in diet-induced thermogenesis, with the sequence alcohol, protein, carbohydrate, and fat. A mixed diet consumed at energy balance results in a diet induced energy expenditure of 5 to 15 % of daily energy expenditure. Values are higher at a relatively high protein and alcohol consumption and lower at a high fat consumption. Protein induced thermogenesis has an important effect on satiety. In conclusion, the main determinants of diet-induced thermogenesis are the energy content and the protein- and alcohol fraction of the diet. Protein plays a key role in body weight regulation through satiety related to diet-induced thermogenesis.

  5. Diet quality assessment indexes

    Directory of Open Access Journals (Sweden)

    Kênia Mara Baiocchi de Carvalho

    2014-10-01

    Full Text Available Various indices and scores based on admittedly healthy dietary patterns or food guides for the general population, or aiming at the prevention of diet-related diseases have been developed to assess diet quality. The four indices preferred by most studies are: the Diet Quality Index; the Healthy Eating Index; the Mediterranean Diet Score; and the Overall Nutritional Quality Index. Other instruments based on these indices have been developed and the words 'adapted', 'revised', or 'new version I, II or III' added to their names. Even validated indices usually find only modest associations between diet and risk of disease or death, raising questions about their limitations and the complexity associated with measuring the causal relationship between diet and health parameters. The objective of this review is to describe the main instruments used for assessing diet quality, and the applications and limitations related to their use and interpretation.

  6. Reversible quantum cellular automata

    CERN Document Server

    Schumacher, B

    2004-01-01

    We define quantum cellular automata as infinite quantum lattice systems with discrete time dynamics, such that the time step commutes with lattice translations and has strictly finite propagation speed. In contrast to earlier definitions this allows us to give an explicit characterization of all local rules generating such automata. The same local rules also generate the global time step for automata with periodic boundary conditions. Our main structure theorem asserts that any quantum cellular automaton is structurally reversible, i.e., that it can be obtained by applying two blockwise unitary operations in a generalized Margolus partitioning scheme. This implies that, in contrast to the classical case, the inverse of a nearest neighbor quantum cellular automaton is again a nearest neighbor automaton. We present several construction methods for quantum cellular automata, based on unitaries commuting with their translates, on the quantization of (arbitrary) reversible classical cellular automata, on quantum c...

  7. Heterogeneous cellular networks

    CERN Document Server

    Hu, Rose Qingyang

    2013-01-01

    A timely publication providing coverage of radio resource management, mobility management and standardization in heterogeneous cellular networks The topic of heterogeneous cellular networks has gained momentum in industry and the research community, attracting the attention of standardization bodies such as 3GPP LTE and IEEE 802.16j, whose objectives are looking into increasing the capacity and coverage of the cellular networks. This book focuses on recent progresses,  covering the related topics including scenarios of heterogeneous network deployment, interference management i

  8. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...... are only ameliorated to a minor degree by a healthy diet....

  9. Nanostructured cellular networks.

    Science.gov (United States)

    Moriarty, P; Taylor, M D R; Brust, M

    2002-12-01

    Au nanocrystals spin-coated onto silicon from toluene form cellular networks. A quantitative statistical crystallography analysis shows that intercellular correlations drive the networks far from statistical equilibrium. Spin-coating from hexane does not produce cellular structure, yet a strong correlation is retained in the positions of nanocrystal aggregates. Mechanisms based on Marangoni convection alone cannot account for the variety of patterns observed, and we argue that spinodal decomposition plays an important role in foam formation.

  10. Energetic deposition of thin metal films

    CERN Document Server

    Al-Busaidy, M S K

    2001-01-01

    deposited films. The primary aim of this thesis was to study the physical effect of energetic deposition metal thin films. The secondary aim is to enhance the quality of the films produced to a desired quality. Grazing incidence X-ray reflectivity (GIXR) measurements from a high-energy synchrotron radiation source were carried out to study and characterise the samples. Optical Profilers Interferometery, Atomic Force Microscope (AFM), Auger electron spectroscopy (AES), Medium energy ion spectroscopy (MEIS), and the Electron microscope studies were the other main structural characterisation tools used. AI/Fe trilayers, as well as multilayers were deposited using a Nordico planar D.C. magnetron deposition system at different voltage biases and pressures. The films were calibrated and investigated. The relation between energetic deposition variation and structural properties was intensely researched. Energetic deposition refers to the method in which the deposited species possess higher kinetic energy and impact ...

  11. Energetic Tuning in Spirocyclic Conjugated Polymers

    Directory of Open Access Journals (Sweden)

    Hugo Bronstein

    2016-01-01

    Full Text Available Precise control of the energy levels in a conjugated polymer is the key to allowing their exploitation in optoelectronic devices. The introduction of spirocycles into conjugated polymers has traditionally been used to enhance their solid state microstructure. Here we present a highly novel method of energetic tuning through the use of electronically active spirocyclic systems. By modifying the size and oxidation state of a heteroatom in an orthogonal spirocycle we demonstrate energetic fine tuning in both the absorption and emission of a conjugated polymer. Furthermore, the synthesis of highly novel triplet-decker spirocyclic conjugated polymers is presented. This new method of energetic manipulation in a conjugated polymer paves the way for future application targeted synthesis of polymers with electronically active spirocycles.

  12. Spin foam models as energetic causal sets

    CERN Document Server

    Cortês, Marina

    2014-01-01

    Energetic causal sets are causal sets endowed by a flow of energy-momentum between causally related events. These incorporate a novel mechanism for the emergence of space-time from causal relations. Here we construct a spin foam model which is also an energetic causal set model. This model is closely related to the model introduced by Wieland, and this construction makes use of results used there. What makes a spin foam model also an energetic causal set is Wieland's identification of new momenta, conserved at events (or four-simplices), whose norms are not mass, but the volume of tetrahedra. This realizes the torsion constraints, which are missing in previous spin foam models, and are needed to relate the connection dynamics to those of the metric, as in general relativity. This identification makes it possible to apply the new mechanism for the emergence of space-time to a spin foam model.

  13. Energetic particle pressure in intense ESP events

    Science.gov (United States)

    Lario, D.; Decker, R. B.; Roelof, E. C.; Viñas, A.-F.

    2015-09-01

    We study three intense energetic storm particle (ESP) events in which the energetic particle pressure PEP exceeded both the pressure of the background thermal plasma Pth and the pressure of the magnetic field PB. The region upstream of the interplanetary shocks associated with these events was characterized by a depression of the magnetic field strength coincident with the increase of the energetic particle intensities and, when plasma measurements were available, a depleted solar wind density. The general feature of cosmic-ray mediated shocks such as the deceleration of the upstream background medium into which the shock propagates is generally observed. However, for those shocks where plasma parameters are available, pressure balance is not maintained either upstream of or across the shock, which may result from the fact that PEP is not included in the calculation of the shock parameters.

  14. Assessment of the energetics of human labor

    Energy Technology Data Exchange (ETDEWEB)

    Giampietro, M. (Istituto Nazionale della Nutrizione, Rome (Italy)); Pimentel, D. (Cornell Univ., Ithaca, NY (USA))

    1990-10-01

    The energetic analysis of farming systems implies an assessment of the energetics of human labor. The energy cost of 1 h of human labor is generally estimated according to its physiological requirement (the hierarchical level at which the assessment is made is at the individual level). A different way of describing the interaction between human society and the ecosystem is presented (assessment referred to the society level). The shift from the individual level to the societal level provides a new perspective when assessing the energetic efficiency of farming. For example, the power level of the system becomes a new and important parameter to consider. Numerical examples illustrate the proposed approach. 4 figs., 12 refs., 1 tab.

  15. Reapplication of energetic materials at fuels

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, L.; Sinquefield, S.; Huey, S.; Lipkin, J.; Shah, D.; Ross, J.; Sclippa, G. [Sandia National Labs., Livermore, CA (United States); Davis, K. [Reaction Engineering Internaional, Salt Lake City, UT (United States)

    1995-05-01

    This investigation addresses the combustion-related aspects of the reapplication of energetic materials as fuels in boilers as an economically viable and environmentally acceptable use of excess energetic materials. The economics of this approach indicate that the revenues from power generation and chemical recovery approximately equal the costs of boiler modification and changes in operation. The primary tradeoff is the cost of desensitizing the fuels against the cost of open burn/open detonation (OB/OD) or other disposal techniques. Two principal combustion-related obstacles to the use of energetic-material-derived fuels are NO{sub x} generation and the behavior of metals. NO{sub x} measurements obtained in this investigation indicate that the nitrated components (nitrocellulose, nitroglycerin, etc.) of energetic materials decompose with NO{sub x} as the primary product. This can lead to high uncontrolled NO{sub x} levels (as high as 2600 ppM on a 3% O{sub 2} basis for a 5% blend of energetic material in the fuel). NO{sub x} levels are sensitive to local stoichiometry and temperature. The observed trends resemble those common during the combustion of other nitrogen containing fuels. Implications for NO{sub x} control strategies are discussed. The behavior of inorganic components in energetic materials tested in this investigation could lead to boiler maintenance problems such as deposition, grate failure, and bed agglomeration. The root cause of the problem is the potentially extreme temperature generated during metal combustion. Implications for furnace selection and operation are discussed.

  16. New Nordic diet versus average Danish diet

    DEFF Research Database (Denmark)

    Khakimov, Bekzod; Poulsen, Sanne Kellebjerg; Savorani, Francesco

    2016-01-01

    A previous study has shown effects of the New Nordic Diet (NND) to stimulate weight loss and lower systolic and diastolic blood pressure in obese Danish women and men in a randomized, controlled dietary intervention study. This work demonstrates long-term metabolic effects of the NND as compared...... metabolites reflecting specific differences in the diets, especially intake of plant foods and seafood, and in energy metabolism related to ketone bodies and gluconeogenesis, formed the predominant metabolite pattern discriminating the intervention groups. Among NND subjects higher levels of vaccenic acid...... diets high in fish, vegetables, fruit, and wholegrain facilitated weight loss and improved insulin sensitivity by increasing ketosis and gluconeogenesis in the fasting state....

  17. Device for Detecting highly energetic photons

    OpenAIRE

    Chemissani Road, Mokhtar; Álvarez Pastor, José; Sánchez Sánchez, Carlos

    2008-01-01

    A device (10) for detecting highly energetic photons, comprising one or more pixelated solid-state detectors (11) for detecting the highly energetic photons; means for providing a high voltage for polarizing said solid-state detectors; one or more pixelated readout elements (30), a readout element being connected to each of said one or more pixelated solid-state detectors (11); an input/output element (12) connected to said readout elements (30) for data input and output; and a base layer (13...

  18. Interfacial energetics approach for analysis of endothelial cell and segmental polyurethane interactions.

    Science.gov (United States)

    Hill, Michael J; Cheah, Calvin; Sarkar, Debanjan

    2016-08-01

    Understanding the physicochemical interactions between endothelial cells and biomaterials is vital for regenerative medicine applications. Particularly, physical interactions between the substratum interface and spontaneously deposited biomacromolecules as well as between the induced biomolecular interface and the cell in terms of surface energetics are important factors to regulate cellular functions. In this study, we examined the physical interactions between endothelial cells and segmental polyurethanes (PUs) using l-tyrosine based PUs to examine the structure-property relations in terms of PU surface energies and endothelial cell organization. Since, contact angle analysis used to probe surface energetics provides incomplete interpretation and understanding of the physical interactions, we sought a combinatorial surface energetics approach utilizing water contact angle, Zisman's critical surface tension (CST), Kaelble's numerical method, and van Oss-Good-Chaudhury theory (vOGCT), and applied to both substrata and serum adsorbed matrix to correlate human umbilical vein endothelial cell (HUVEC) behavior with surface energetics of l-tyrosine based PU surfaces. We determined that, while water contact angle of substratum or adsorbed matrix did not correlate well with HUVEC behavior, overall higher polarity according to the numerical method as well as Lewis base character of the substratum explained increased HUVEC interaction and monolayer formation as opposed to organization into networks. Cell interaction was also interpreted in terms of the combined effects of substratum and adsorbed matrix polarity and Lewis acid-base character to determine the effect of PU segments.

  19. [Diet and atherosclerosis].

    Science.gov (United States)

    Garrido, J A; Garcés, C; de Oya, M

    1998-01-01

    The relationship between diet and atherosclerosis is due to the diet influence on lipoprotein composition. However, because of the multifactorial basis of the atherosclerosis, diet components have another potential intervention mechanisms in the atherosclerosis process, such as the influence on other cardiovascular risk factors (hypertension, obesity, diabetes) or the influence on the coagulation system and the relationship endothelium-platelets. We will review the effect of diet components on these factors, specially its effects on the haemostasia system, which alteration is responsible for provoking ischemic heart disease. We have to consider that the main objective when treating dyslipidaemias, besides of avoiding acute pancreatitis in cases of strong hypertrigliceridaemia, is to prevent arteriosclerosis development and its clinical manifestations such as ischemic heart disease. Besides, we know that genetic, in addition to provoke familial susceptibility to atherosclerosis, has an essential importance in the response to ambiental factors as diet is.

  20. Vegetarian diets and children.

    Science.gov (United States)

    Sanders, T A; Reddy, S

    1994-05-01

    The diets and growth of children reared on vegetarian diets are reviewed. Excessive bulk combined with low energy density can be a problem for children aged Diets that have a high content of phytate and other modifiers of mineral absorption are associated with an increased prevalence of rickets and iron-deficiency anemia. Vitamin B-12 deficiency is a real hazard in unsupplemented or unfortified vegan and vegetarian diets. It is suggested that vegans and vegetarians should use oils with a low ratio of linoleic to linolenic acid in view of the recently recognized role of docosahexaenoic acid in visual functioning. If known pitfalls are avoided, the growth and development of children reared on both vegan and vegetarian diets appears normal.

  1. DIET at the nanoscale

    Science.gov (United States)

    Dujardin, G.; Boer-Duchemin, E.; Le Moal, E.; Mayne, A. J.; Riedel, D.

    2016-01-01

    We review the long evolution of DIET (Dynamics at surfaces Induced by Electronic Transitions) that began in the 1960s when Menzel, Gomer and Redhead proposed their famous stimulated desorption model. DIET entered the "nanoscale" in the 1990s when researchers at Bell Labs and IBM realized that the Scanning Tunneling Microscope (STM) could be used as an atomic size source of electrons to electronically excite individual atoms and molecules on surfaces. Resonant and radiant Inelastic Electron Tunneling (IET) using the STM have considerably enlarged the range of applications of DIET. Nowadays, "DIET at the nanoscale" covers a broad range of phenomena at the atomic-scale. This includes molecular dynamics (dissociation, desorption, isomerization, displacement, chemical reactions), vibrational spectroscopy and dynamics, spin spectroscopy and manipulation, luminescence spectroscopy, Raman spectroscopy and plasmonics. Future trends of DIET at the nanoscale offer exciting prospects for new methods to control light and matter at the nanoscale.

  2. Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet

    Directory of Open Access Journals (Sweden)

    Alessandra Ferramosca

    2015-01-01

    Full Text Available In recent years, several studies focused their attention on the role of dietary fats in the pathogenesis of hepatic steatosis. It has been demonstrated that a high-fat diet is able to induce hyperglycemia, hyperinsulinemia, obesity, and nonalcoholic fatty liver disease. On the other hand, krill oil, a novel dietary supplement of n-3 PUFAs, has the ability to improve lipid and glucose metabolism, exerting possible protective effects against hepatic steatosis. In this study we have investigated the effects of krill oil on mitochondrial energetic metabolism in animals fed a high-fat diet. To this end, male Sprague-Dawley rats were divided into three groups and fed for 4 weeks with a standard diet (control group, a diet with 35% fat (HF group, or a high-fat diet supplemented with 2.5% krill oil (HF+KO group. The obtained results suggest that krill oil promotes the burning of fat excess introduced by the high-fat diet. This effect is obtained by stimulating mitochondrial metabolic pathways such as fatty acid oxidation, Krebs cycle, and respiratory chain complexes activity. Modulation of the expression of carrier proteins involved in mitochondrial uncoupling was also observed. Overall, krill oil counteracts the negative effects of a high-fat diet on mitochondrial energetic metabolism.

  3. Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet.

    Science.gov (United States)

    Ferramosca, Alessandra; Conte, Annalea; Zara, Vincenzo

    2015-01-01

    In recent years, several studies focused their attention on the role of dietary fats in the pathogenesis of hepatic steatosis. It has been demonstrated that a high-fat diet is able to induce hyperglycemia, hyperinsulinemia, obesity, and nonalcoholic fatty liver disease. On the other hand, krill oil, a novel dietary supplement of n-3 PUFAs, has the ability to improve lipid and glucose metabolism, exerting possible protective effects against hepatic steatosis. In this study we have investigated the effects of krill oil on mitochondrial energetic metabolism in animals fed a high-fat diet. To this end, male Sprague-Dawley rats were divided into three groups and fed for 4 weeks with a standard diet (control group), a diet with 35% fat (HF group), or a high-fat diet supplemented with 2.5% krill oil (HF+KO group). The obtained results suggest that krill oil promotes the burning of fat excess introduced by the high-fat diet. This effect is obtained by stimulating mitochondrial metabolic pathways such as fatty acid oxidation, Krebs cycle, and respiratory chain complexes activity. Modulation of the expression of carrier proteins involved in mitochondrial uncoupling was also observed. Overall, krill oil counteracts the negative effects of a high-fat diet on mitochondrial energetic metabolism.

  4. Primeira onda folicular e ovulação de vacas primíparas da raça Holandesa alimentadas com diferentes fontes energéticas durante o período de transição First follicular wave and first postpartum ovulation of primiparous Holstein dairy cows receiving diets with different energetic sources during the transition period

    Directory of Open Access Journals (Sweden)

    M.A.T. Artunduaga

    2010-02-01

    Full Text Available Avaliou-se o efeito da adição de diferentes fontes energéticas na dieta de vacas leiteiras, durante o período de transição, sobre a primeira onda folicular e o intervalo parto-primeira ovulação. Foram utilizadas 40 vacas primíparas da raça Holandesa, no período de 28 dias antes da data prevista do parto até o 46º dia pós-parto. As vacas foram submetidas a quatro tratamentos (grupos durante o período de transição: grupo-controle e grupos tratados com, Megalac-E (sais de cálcio de ácidos graxos da soja, soja tostada ou propileno-glicol. Avaliações ultrassonográficas foram realizadas do 10º ao 46º dia pós-parto, com a classificação dos folículos ovarianos em quatro classes (I, II, III e IV de tamanho e do registro do volume do tecido luteal. Amostras de sangue foram coletadas nos dias 10, 17, 24, 31, 38 e 45 após o parto para análise de progesterona. O padrão de crescimento folicular mais eficiente foi apresentado pelos animais dos grupos Megalac-E e propileno-glicol, que foram caracterizados pela redução no número de folículos de classes I e II e aumento no número de folículos de classes III e IV. Os intervalos entre o parto e a primeira ovulação dos grupos controle, Megalac-E, soja tostada e propileno-glicol foram de 29, 23, 30 e 37 dias, respectivamente (PThe effects of different energy sources added to the diet on the first postpartum ovarian follicle wave and first postpartum ovulation were evaluated. Forty primiparous Holstein dairy cows were used from 28 days before the expected calving date until 46 days postpartum. Cows were randomly allotted to the following groups: control, Megalac-E calcium salts of soybean fatty acid, toasted soybean and propylene glycol. Ovarian structures were scanned using ultrasound from 10 to 46 days postpartum. Follicles were classified according to the diameter in classes I, II, III, and IV and the luteal tissue volume was registered when present. Blood samples for

  5. Diet for rapid weight loss

    Science.gov (United States)

    Academy of Nutrition and Dietetics. Staying away from fad diets. Updated January 4, 2016. www.eatright.org/resource/health/weight-loss/fad-diets/staying-away-from-fad-diets . Accessed May 25, 2016. Cowley MA, Brown WA, Considine ...

  6. Diet and Nutrition in Porphyria

    Science.gov (United States)

    ... Art Sale You are here Home Diet and Nutrition A proper diet is important to all individuals, ... alter food intake. Therefore, attention to diet and nutrition is important in almost any disease. Porphyrias are ...

  7. Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

    OpenAIRE

    Westman Eric C; Kraft Bryan D

    2009-01-01

    Abstract We report the unexpected resolution of longstanding schizophrenic symptoms after starting a low-carbohydrate, ketogenic diet. After a review of the literature, possible reasons for this include the metabolic consequences from the elimination of gluten from the diet, and the modulation of the disease of schizophrenia at the cellular level.

  8. Energetic utilization of dietary fiber in pigs

    NARCIS (Netherlands)

    Rijnen, M.M.J.A.

    2003-01-01

    The energetic utilization of fermentable dietary fiber (fDF) of different fiber sources and its relation to physical activity and housing conditions was studied in three experiments. In all experiments the daily intake of digestible nutrients, nitrogen and energy balances, heat production, and activ

  9. Migration on Wings Aerodynamics and Energetics

    CERN Document Server

    Kantha, Lakshmi

    2012-01-01

    This book is an effort to explore the technical aspects associated with bird flight and migration on wings. After a short introduction on the birds migration, the book reviews the aerodynamics and Energetics of Flight and presents the calculation of the Migration Range. In addition, the authors explains aerodynamics of the formation flight and finally introduces great flight diagrams.

  10. Energy Harvesting from Energetic Porous Silicon

    Science.gov (United States)

    2016-07-01

    ARL-TR-7719 ● JULY 2016 US Army Research Laboratory Energy Harvesting from Energetic Porous Silicon by Louis B Levine, Matthew...it is no longer needed. Do not return it to the originator. ARL-TR-7719 ● JULY 2016 US Army Research Laboratory Energy ...

  11. Major minority: energetic particles in fusion plasmas

    Science.gov (United States)

    Breizman, B. N.; Sharapov, S. E.

    2011-05-01

    This paper describes advances made in the field of energetic-particle physics since the topical review of Alfvén eigenmode observations in toroidal plasmas (Wong 1999 Plasma Phys. Control. Fusion 41 R1-R56). The development of plasma confinement scenarios with reversed magnetic shear and significant population of energetic particles, and the development of novel energetic-particle diagnostics were the main milestones in the past decade, and these are the main experimental subjects of this review. The theory of Alfvén cascade eigenmodes in reversed-shear tokamaks and its use in magnetohydrodynamic spectroscopy are presented. Based on experimental observations and nonlinear theory of energetic-particle instabilities in the near-threshold regime, the frequency-sweeping events for spontaneously formed phase-space holes and clumps and the evolution of the fishbone oscillations are described. The multi-mode scenarios of enhanced particle transport are discussed and a brief summary is given of several engaging research topics that are beyond the authors' direct involvement.

  12. Error propagation in energetic carrying capacity models

    Science.gov (United States)

    Pearse, Aaron T.; Stafford, Joshua D.

    2014-01-01

    Conservation objectives derived from carrying capacity models have been used to inform management of landscapes for wildlife populations. Energetic carrying capacity models are particularly useful in conservation planning for wildlife; these models use estimates of food abundance and energetic requirements of wildlife to target conservation actions. We provide a general method for incorporating a foraging threshold (i.e., density of food at which foraging becomes unprofitable) when estimating food availability with energetic carrying capacity models. We use a hypothetical example to describe how past methods for adjustment of foraging thresholds biased results of energetic carrying capacity models in certain instances. Adjusting foraging thresholds at the patch level of the species of interest provides results consistent with ecological foraging theory. Presentation of two case studies suggest variation in bias which, in certain instances, created large errors in conservation objectives and may have led to inefficient allocation of limited resources. Our results also illustrate how small errors or biases in application of input parameters, when extrapolated to large spatial extents, propagate errors in conservation planning and can have negative implications for target populations.

  13. Energetic particle instabilities in fusion plasmas

    NARCIS (Netherlands)

    Sharapov, S. E.; Alper, B.; Berk, H. L.; Borba, D. N.; Breizman, B. N.; Challis, C. D.; Classen, I.G.J.; Edlund, E. M.; Eriksson, J.; Fasoli, A.; Fredrickson, E. D.; Fu, G. Y.; Garcia-Munoz, M.; Gassner, T.; Ghantous, K.; Goloborodko, V.; Gorelenkov, N. N.; Gryaznevich, M. P.; Hacquin, S.; Heidbrink, W. W.; Hellesen, C.; Kiptily, V. G.; Kramer, G. J.; Lauber, P.; Lilley, M. K.; Lisak, M.; Nabais, F.; Nazikian, R.; Nyqvist, R.; Osakabe, M.; C. Perez von Thun,; Pinches, S. D.; Podesta, M.; Porkolab, M.; Shinohara, K.; Schoepf, K.; Todo, Y.; Toi, K.; VanZeeland, M. A.; Voitsekhovich, I.; White, R. B.; Yavorskij, V.; ITPA EP TG Contributors,; JET-EFDA Contributors,

    2013-01-01

    Remarkable progress has been made in diagnosing energetic particle instabilities on present-day machines and in establishing a theoretical framework for describing them. This overview describes the much improved diagnostics of Alfvén instabilities and modelling tools developed world-wide, and discus

  14. Complex Nanostructures: Synthesis and Energetic Applications

    OpenAIRE

    Dunwei Wang; Stafford Sheehan; Sa Zhou; Yongjing Lin; Xiaohua Liu

    2010-01-01

    Connected through single crystalline junctions, low dimensional materials such as nanowires and nanorods form complex nanostructures. These new materials exhibit mechanical strengths and electrical conductivities superior to their constituents while maintaining comparable surface areas, an attribute ideal for energetic applications. More efficient solar cells, higher capacity batteries and better performing photoelectrochemical cells have been built using these materials. This article reviews...

  15. Energetics of the Semiconductor-Electrolyte Interface.

    Science.gov (United States)

    Turner, John A.

    1983-01-01

    The use of semiconductors as electrodes for electrochemistry requires an understanding of both solid-state physics and electrochemistry, since phenomena associated with both disciplines are seen in semiconductor/electrolyte systems. The interfacial energetics of these systems are discussed. (JN)

  16. Energetics of geostrophic adjustment in rotating flow

    Science.gov (United States)

    Juan, Fang; Rongsheng, Wu

    2002-09-01

    Energetics of geostrophic adjustment in rotating flow is examined in detail with a linear shallow water model. The initial unbalanced flow considered first falls tinder two classes. The first is similar to that adopted by Gill and is here referred to as a mass imbalance model, for the flow is initially motionless but with a sea surface displacement. The other is the same as that considered by Rossby and is referred to as a momentum imbalance model since there is only a velocity perturbation in the initial field. The significant feature of the energetics of geostrophic adjustment for the above two extreme models is that although the energy conversion ratio has a large case-to-case variability for different initial conditions, its value is bounded below by 0 and above by 1 / 2. Based on the discussion of the above extreme models, the energetics of adjustment for an arbitrary initial condition is investigated. It is found that the characteristics of the energetics of geostrophic adjustment mentioned above are also applicable to adjustment of the general unbalanced flow under the condition that the energy conversion ratio is redefined as the conversion ratio between the change of kinetic energy and potential energy of the deviational fields.

  17. ENERGETIC CHARGE OF AN INFORMATION PROCESS

    Directory of Open Access Journals (Sweden)

    Popova T.M.

    2009-12-01

    Full Text Available Main laws of technical thermodynamics are universal and could be applied to processes other than thermodynamic ones. The results of the comparison of peculiarities of irreversible informational and thermodynamic processes are presented in the article and a new term “Infopy” is used. A more precise definition of “infopy” as an energetic charge is given in the article.

  18. Epigenetics and Cellular Metabolism

    Science.gov (United States)

    Xu, Wenyi; Wang, Fengzhong; Yu, Zhongsheng; Xin, Fengjiao

    2016-01-01

    Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external stimuli into transcriptional response. Emerging evidence reveals the concept that epigenetic signatures are essential for the proper maintenance of cellular metabolism. On the other hand, the metabolite, a main environmental input, can also influence the processing of epigenetic memory. Here, we summarize the recent research progress in the epigenetic regulation of cellular metabolism and discuss how the dysfunction of epigenetic machineries influences the development of metabolic disorders such as diabetes and obesity; then, we focus on discussing the notion that manipulating metabolites, the fuel of cell metabolism, can function as a strategy for interfering epigenetic machinery and its related disease progression as well. PMID:27695375

  19. Architected Cellular Materials

    Science.gov (United States)

    Schaedler, Tobias A.; Carter, William B.

    2016-07-01

    Additive manufacturing enables fabrication of materials with intricate cellular architecture, whereby progress in 3D printing techniques is increasing the possible configurations of voids and solids ad infinitum. Examples are microlattices with graded porosity and truss structures optimized for specific loading conditions. The cellular architecture determines the mechanical properties and density of these materials and can influence a wide range of other properties, e.g., acoustic, thermal, and biological properties. By combining optimized cellular architectures with high-performance metals and ceramics, several lightweight materials that exhibit strength and stiffness previously unachievable at low densities were recently demonstrated. This review introduces the field of architected materials; summarizes the most common fabrication methods, with an emphasis on additive manufacturing; and discusses recent progress in the development of architected materials. The review also discusses important applications, including lightweight structures, energy absorption, metamaterials, thermal management, and bioscaffolds.

  20. Spatial and temporal variation of diet within a presumed metapopulation of Adelie penguins

    Science.gov (United States)

    Ainley, D.G.; Ballard, G.; Barton, K.J.; Karl, B.J.; Rau, G.H.; Ribic, C.A.; Wilson, P.R.

    2003-01-01

    We investigated temporal and spatial variability in the diet of chick-provisioning Ade??lie Penguins (Pygoscelis adeliae) breeding at all colonies within one isolated cluster in the southwestern Ross Sea, Antarctica, 1994-2000. We wished to determine if prey quality explained different population growth and emigration rates among colonies. Diet composition was described both by conventional means (stomach samples) and by analysis of stable isotopes in chick tissues (toenails of individuals killed by skuas [Stercorarius maccormicki]). Diets were similar among the four study colonies compared to the disparity apparent among 14 widely spaced sites around the continent. Calorimetry indicated that fish are more energetically valuable than krill, implying that if diet varied by colony, diet quality could attract recruits and help to explain differential rates of colony growth. However, a multiple-regression analysis indicated that diet varied as a function of year, time within the year, and percent of foraging area covered by sea ice, but not by colony location. Stable isotopes revealed similarity of diet at one colony where conventional sampling was not possible. We confirmed that sea ice importantly affects diet composition of this species in neritic waters, and found that (1) quality of summer diet cannot explain different population growth rates among colonies, and (2) stable isotope analysis of chick tissues (toenails) is a useful tool to synoptically describe diet in this species over a large area.

  1. Cellular blue naevus

    Directory of Open Access Journals (Sweden)

    Mittal R

    2001-01-01

    Full Text Available A 31-year-old man had asymptomatic, stationary, 1.5X2 cm, shiny, smooth, dark blue nodule on dorsum of right hand since 12-14 years. In addition he had developed extensive eruption of yellow to orange papulonodular lesions on extensors of limbs and buttocks since one and half months. Investigations confirmed that yellow papules were xanthomatosis and he had associated diabetes mellitus and hyperlipidaemia. Biopsy of blue nodule confirmed the clinical diagnosis of cellular blue naevus. Cellular blue naevus is rare and its association with xanthomatosis and diabetes mellitus were interesting features of above patients which is being reported for its rarity.

  2. Energetic costs and implications of the intake of plant secondary metabolites on digestive and renal morphology in two austral passerines.

    Science.gov (United States)

    Barceló, Gonzalo; Ríos, Juan Manuel; Maldonado, Karin; Sabat, Pablo

    2016-07-01

    Seed-eating birds have a diet of high nutritional value; however, they must cope with plant secondary metabolites (PSM). We postulated that the detoxification capacity of birds is associated with a metabolic cost, given that the organs responsible for detoxification significantly contribute to energetic metabolism. We used an experimental approach to assess the effects of phenol-enriched diets on two passerines with different feeding habits: the omnivorous rufous-collared sparrow (Zonotrichia capensis) and the granivorous common diuca-finch (Diuca diuca). The birds were fed with one of three diets: control diet, supplemented with tannic acid, or supplemented with Opuntia ficus-indica phenolic extract (a common food of the sparrow but not the finch). After 5 weeks of exposure to the diets, we measured basal metabolic rates (BMR), energy intake, glucuronic acid output and digestive and kidney structure. In both species, detoxification capacity expressed as glucuronic acid output was higher in individuals consuming phenol-enriched diets compared to the control diet. However, whereas sparrows increase energy intake and intestinal mass when feeding on phenol-enriched diets, finches had lower intestinal mass and energy intake remains stable. Furthermore, sparrows had higher BMR on phenol-enriched diets compared to the control group, whereas in the finches BMR remains unchanged. Interspecific differences in response to phenols intake may be determined by the dietary habits of these species. While both species can feed on moderate phenolic diets for 5 weeks, energy costs may differ due to different responses in food intake and organ structure to counteract the effects of PSM intake.

  3. Diet quality and markers of endothelial function: The CARDIA study

    NARCIS (Netherlands)

    Sijtsma, F.P.C.; Meyer, K.A.; Steffen, L.M.; Horn, van L.; Shikany, J.M.; Odegaard, A.O.; Gross, M.D.; Kromhout, D.; Jacobs, D.R.

    2014-01-01

    Background and aim: Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs. Methods and results: In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at ye

  4. Inversão da sacarose utilizando ácido cítrico e suco de limão para preparo de dieta energética de Apis mellifera Linnaeus, 1758 Inversion of the sucrose using citric acid and lemon juice for preparing energetic diet of Apis mellifera Linnaeus, 1758

    Directory of Open Access Journals (Sweden)

    Deodoro Magno Brighenti

    2011-04-01

    nectar shortage, food supplementation using "inverted sugar" obtained by sucrose hydrolysis in an acid environment by heating can be supplied to the hive, forming a glucose and fructose mixture. The acid usually used in such a reaction is the citric acid, however, due to the difficulty that small producers have to obtain the product commercially, an alternative would be to replace it with lemon juice. The objective of this work was to quantify the inversion of sucrose present in Apis mellifera worker diets by employing commercial citric acid and lemon juice. A total of 21 aqueous solutions of granulated sugar at the proportion of 100 g/100 mL were prepared, placing in each one 1.0; 2.0; 3.0; 5.0; 10.0; 15.0 or 20.0 mL of the juices of the Galego [Citrus aurantifolia (C. Swingle], Tahiti [Citrus latifolia Tanaka] or Cravo [Citrus limonia (L. Osbeck] lemon varieties. In addition to those, six other aqueous sucrose solutions were prepared by adding 0.0 (control; 0.16; 0.3; 0.5 and 0.7 g citric acid. Sucrose inversion was quantified by using the Somogyi-Nelson method. For the Cravo lemon, the lowest inversion rate was found. Regarding the addition of citric acid, it was estimated that in placing 0.1 g, the inversion was of 12.2% while with 0.16 g, an inversion of 18.8% sucrose present in the solution. The maximum amount of citric acid to be added was estimated to be 0.18 g, adopting as a criterion the mean pH of 3.3 in Africanized bee honey. If Galego, Tahiti and Cravo lemon juices are used as replacements for the citric acid, the maximum added amount should be 2.1, 3.6 and 5.3 mL, respectively, for each 100 g sugar/100 mL water, at fixed pH of 3.3. Considering the inversion rate and pH level recommended for the use of citric acid, Tahiti lemon juice provides better results.

  5. High-fat diet alters gut microbiota physiology in mice.

    Science.gov (United States)

    Daniel, Hannelore; Gholami, Amin Moghaddas; Berry, David; Desmarchelier, Charles; Hahne, Hannes; Loh, Gunnar; Mondot, Stanislas; Lepage, Patricia; Rothballer, Michael; Walker, Alesia; Böhm, Christoph; Wenning, Mareike; Wagner, Michael; Blaut, Michael; Schmitt-Kopplin, Philippe; Kuster, Bernhard; Haller, Dirk; Clavel, Thomas

    2014-02-01

    The intestinal microbiota is known to regulate host energy homeostasis and can be influenced by high-calorie diets. However, changes affecting the ecosystem at the functional level are still not well characterized. We measured shifts in cecal bacterial communities in mice fed a carbohydrate or high-fat (HF) diet for 12 weeks at the level of the following: (i) diversity and taxa distribution by high-throughput 16S ribosomal RNA gene sequencing; (ii) bulk and single-cell chemical composition by Fourier-transform infrared- (FT-IR) and Raman micro-spectroscopy and (iii) metaproteome and metabolome via high-resolution mass spectrometry. High-fat diet caused shifts in the diversity of dominant gut bacteria and altered the proportion of Ruminococcaceae (decrease) and Rikenellaceae (increase). FT-IR spectroscopy revealed that the impact of the diet on cecal chemical fingerprints is greater than the impact of microbiota composition. Diet-driven changes in biochemical fingerprints of members of the Bacteroidales and Lachnospiraceae were also observed at the level of single cells, indicating that there were distinct differences in cellular composition of dominant phylotypes under different diets. Metaproteome and metabolome analyses based on the occurrence of 1760 bacterial proteins and 86 annotated metabolites revealed distinct HF diet-specific profiles. Alteration of hormonal and anti-microbial networks, bile acid and bilirubin metabolism and shifts towards amino acid and simple sugars metabolism were observed. We conclude that a HF diet markedly affects the gut bacterial ecosystem at the functional level.

  6. Promising Medicated Diet

    Institute of Scientific and Technical Information of China (English)

    Yang Wei

    2009-01-01

    @@ The founding conference of World Federation of Chinese Medicine Societies-Special Committee of Medicated Diet & Dietotherapy(WFCMS-SCMDAD).and the first world medicated diet and life nurturing academic seminar was held in the Great Hall of the People.Beijing,China,on August 11.A total of 400 experts and professors on medicated diet and life nurturing from 17 countries and regions including Japan,ROK,U.S.,Canada,U.K.,ect.Honorary President Professor Cai Guangxian delivered a welcoming speech to declare the organization's found.

  7. [Breastfeeding and vegan diet].

    Science.gov (United States)

    Wagnon, J; Cagnard, B; Bridoux-Henno, L; Tourtelier, Y; Grall, J-Y; Dabadie, A

    2005-10-01

    Vegan diet in lactating women can induce vitamin B12 deficiency for their children with risk of an impaired neurological development. A 9.5-month-old girl presented with impaired growth and severe hypotonia. She had a macrocytic anemia secondary to vitamin B12 deficiency. MRI showed cerebral atrophy. She was exclusively breastfed. Her mother was also vitamin B12 deficient, secondary to a vegan diet. She had a macrocytic anemia when discharged from the maternity. Vegan diet is a totally inadequate regimen for pregnant and lactating women, especially for their children. Prevention is based on screening, information and vitamin supplementation.

  8. Cellular rehabilitation of photobiomodulation

    Science.gov (United States)

    Liu, Timon Cheng-Yi; Yuan, Jian-Qin; Wang, Yan-Fang; Xu, Xiao-Yang; Liu, Song-Hao

    2007-05-01

    Homeostasis is a term that refers to constancy in a system. A cell in homeostasis normally functions. There are two kinds of processes in the internal environment and external environment of a cell, the pathogenic processes (PP) which disrupts the old homeostasis (OH), and the sanogenetic processes (SP) which restores OH or establishes a new homeostasis (NH). Photobiomodualtion (PBM), the cell-specific effects of low intensity monochromatic light or low intensity laser irradiation (LIL) on biological systems, is a kind of modulation on PP or SP so that there is no PBM on a cell in homeostasis. There are two kinds of pathways mediating PBM, the membrane endogenetic chromophores mediating pathways which often act through reactive oxygen species, and membrane proteins mediating pathways which often enhance cellular SP so that it might be called cellular rehabilitation. The cellular rehabilitation of PBM will be discussed in this paper. It is concluded that PBM might modulate the disruption of cellular homeostasis induced by pathogenic factors such as toxin until OH has been restored or NH has been established, but can not change homeostatic processes from one to another one.

  9. Cellular Response to Irradiation

    Institute of Scientific and Technical Information of China (English)

    LIU Bo; YAN Shi-Wei

    2011-01-01

    To explore the nonlinear activities of the cellular signaling system composed of one transcriptional arm and one protein-interaction arm, we use an irradiation-response module to study the dynamics of stochastic interactions.It is shown that the oscillatory behavior could be described in a unified way when the radiation-derived signal and noise are incorporated.

  10. Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity

    Science.gov (United States)

    Dalmasso, Giovanni; Marin Zapata, Paula Andrea; Brady, Nathan Ryan; Hamacher-Brady, Anne

    2017-01-01

    Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network. These morphological and mobility dynamics are essential for maintaining mitochondrial functional homeostasis, and alterations both impact and reflect cellular stress states. Mitochondrial homeostasis is further dependent on production (biogenesis) and the removal of damaged mitochondria by selective autophagy (mitophagy). While mitochondrial function, dynamics, biogenesis and mitophagy are highly-integrated processes, it is not fully understood how systemic control in the cell is established to maintain homeostasis, or respond to bioenergetic demands. Here we used agent-based modeling (ABM) to integrate molecular and imaging knowledge sets, and simulate population dynamics of mitochondria and their response to environmental energy demand. Using high-dimensional parameter searches we integrated experimentally-measured rates of mitochondrial biogenesis and mitophagy, and using sensitivity analysis we identified parameter influences on population homeostasis. By studying the dynamics of cellular subpopulations with distinct mitochondrial masses, our approach uncovered system properties of mitochondrial populations: (1) mitochondrial fusion and fission activities rapidly establish mitochondrial sub-population homeostasis, and total cellular levels of mitochondria alter fusion and fission activities and subpopulation distributions; (2) restricting the directionality of mitochondrial mobility does not alter morphology subpopulation distributions, but increases network transmission dynamics; and (3) maintaining mitochondrial mass homeostasis and responding to bioenergetic stress requires the integration of mitochondrial dynamics with the cellular bioenergetic state. Finally, (4) our model suggests sources of, and stress conditions amplifying

  11. Energetic statistics of Baleares Islands in 1993. Estatistiques energetiques de les Illes Balears 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    This annual report summarizes the energetic and demand. It is focussed to analyze the energetic fuel (natural gas). The environment, and energetic supplies. Statistical data of energetic production, distribution and consumption in 1992 and 1993 are introduced.

  12. Diabetes diet - gestational

    Science.gov (United States)

    Gestational diabetes diet ... excellent sources of B vitamins, protein, iron, and zinc. SWEETS Sweets are high in fat and sugar, ... American Diabetes Association. Nutrition recommendations and ... statement of the American Diabetes Association. Diabetes Care. ...

  13. Sea Lion Diet Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — California sea lions pup and breed at four of the nine Channel Islands in southern California. Since 1981, SWFSC MMTD has been conducting a diet study of sea lions...

  14. Low-fiber diet

    Science.gov (United States)

    ... slow your bowel movements. This helps decrease diarrhea, gas, and bloating. Your doctor may recommend that you follow a low-fiber diet when you have a flare-up of: Irritable bowel syndrome Diverticulitis Crohn disease ...

  15. Diets that Work

    Science.gov (United States)

    ... non-vegetarians. A vegetarian diet can help fight heart disease and high blood pressure. Sample Dinner Menus Vegetarian Spaghetti with Mushroom-Tomato-Asiago Cheese Sauce Steamed Green Beans with Pine Nuts Fruit Salad Vegan Roasted Vegetables with Whole ...

  16. Diet and cancer

    Science.gov (United States)

    Fiber and cancer; Cancer and fiber; Nitrates and cancer; Cancer and nitrates ... DIET AND BREAST CANCER The link between nutrition and breast cancer has been well studied. To reduce risk of breast cancer the American ...

  17. Anti-inflammatory Diets.

    Science.gov (United States)

    Sears, Barry

    2015-01-01

    Chronic disease is driven by inflammation. This article will provide an overview on how the balance of macronutrients and omega-6 and omega-3 fatty acids in the diet can alter the expression of inflammatory genes. In particular, how the balance of the protein to glycemic load of a meal can alter the generation of insulin and glucagon and the how the balance of omega-6 and omega-3 fatty acids can effect eicosanoid formation. Clinical results on the reduction of inflammation following anti-inflammatory diets are discussed as well as the molecular targets of anti-inflammatory nutrition. To overcome silent inflammation requires an anti-inflammatory diet (with omega-3s and polyphenols, in particular those of Maqui). The most important aspect of such an anti-inflammatory diet is the stabilization of insulin and reduced intake of omega-6 fatty acids. The ultimate treatment lies in reestablishing hormonal and genetic balance to generate satiety instead of constant hunger. Anti-inflammatory nutrition, balanced 40:30:30 with caloric restriction, should be considered as a form of gene silencing technology, in particular the silencing of the genes involved in the generation of silent inflammation. To this anti-inflammatory diet foundation supplemental omega-3 fatty acids at the level of 2-3 g of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) per day should be added. Finally, a diet rich in colorful, nonstarchy vegetables would contribute adequate amounts of polyphenols to help not only to inhibit nuclear factor (NF)-κB (primary molecular target of inflammation) but also activate AMP kinase. Understanding the impact of an anti-inflammatory diet on silent inflammation can elevate the diet from simply a source of calories to being on the cutting edge of gene-silencing technology.

  18. Energetic balance in poultry house; Balanco energetico em galpao de frangos de corte

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Tania M.B. [Universidade Estadual de Mato Grosso do Sul, Aquidauana, MS (Brazil). Unidade Universitaria]. E-mail: santostm@terra.com.br; Lucas Junior, Jorge de [UNESP, Jaboticabal, SP (Brazil). Faculdade de Ciencias Agrarias e Veterinarias. Dept. de Engenharia Rural

    2004-01-15

    This work aimed to evaluate the energy balance in broiler house. It was studied eight broiler flocks in a commercial broiler house in Sertanejo Poultry Industry (Sertaozinho, SP, Brazil). It was quantified the caloric power of each component that involves the production process (direct and indirect, in and out). that was used in the calculation of the energetic efficiency coefficient, The food consumption (kg), broiler live weight (kg), dad birds/refused, poultry litter production (kg), water (L), liquefied petroleum gas (kg), electric energy (kWh), fuel (L), machinery and implements (hours) and installation and equipment (m{sup 2} and hours) were evaluated. The energy flow obtained by energetic balance showed that the activity presented high energy consumption, with 28% of energetic efficiency. From the direct energy input in the system, 10.2% concerned to the shaving wood, 0.3% to the birds, 86.5% to the diet, 0.8% to the electricity and 2.1% to the LPG. About the output energy, 46.7% could return to the system in the biogas form, generated from the anaerobic digestion of poultry litter. (author)

  19. Energetic conditions promoting top-down control of prey by predators.

    Directory of Open Access Journals (Sweden)

    Kristin N Marshall

    Full Text Available Humans remove large amounts of biomass from natural ecosystems, and large bodied high trophic level animals are especially sensitive and vulnerable to exploitation. The effects of removing top-predators on food webs are often difficult to predict because of limited information on species interaction strengths. Here we used a three species predator-prey model to explore relationships between energetic properties of trophodynamic linkages and interaction strengths to provide heuristic rules that indicate observable energetic conditions that are most likely to lead to stable and strong top-down control of prey by predator species. We found that strong top-down interaction strengths resulted from low levels of energy flow from prey to predators. Strong interactions are more stable when they are a consequence of low per capita predation and when predators are subsidized by recruitment. Diet composition also affects stability, but the relationship depends on the form of the functional response. Our results imply that for generalist satiating predators, strong top-down control on prey is most likely for prey items that occupy a small portion of the diet and when density dependent recruitment is moderately high.

  20. Specific Carbohydrate Diet: Does It Work?

    Science.gov (United States)

    ... Specific Carbohydrate Diet (SCD) Go Back The Specific Carbohydrate Diet (SCD) Email Print + Share There is no ... diet that has received attention is the Specific Carbohydrate Diet. This diet limits poorly digestible carbohydrates to ...

  1. Vegan diets and hypothyroidism.

    Science.gov (United States)

    Tonstad, Serena; Nathan, Edward; Oda, Keiji; Fraser, Gary

    2013-11-20

    Diets eliminating animal products have rarely been associated with hypothyroidism but may protect against autoimmune disease. Thus, we investigated whether risk of hypothyroidism was associated with vegetarian compared to omnivorous dietary patterns. The Adventist Health Study-2 was conducted among church members in North America who provided data in a self-administered questionnaire. Hypothyroidism was queried at baseline in 2002 and at follow-up to 2008. Diet was examined as a determinant of prevalent (n = 4237 of 65,981 [6.4%]) and incident cases (1184 of 41,212 [2.9%]) in multivariate logistic regression models, controlled for demographics and salt use. In the prevalence study, in addition to demographic characterstics, overweight and obesity increased the odds (OR 1.32, 95% CI: 1.22-1.42 and 1.78, 95% CI: 1.64-1.93, respectively). Vegan versus omnivorous diets tended to be associated with reduced risk (OR 0.89, 95% CI: 0.78-1.01, not statistically significant) while a lacto-ovo diet was associated with increased risk (OR 1.09, 95% CI: 1.01-1.18). In the incidence study, female gender, white ethnicity, higher education and BMI were predictors of hypothyroidism. Following a vegan diet tended to be protective (OR 0.78, 95% CI: 0.59-1.03, not statistically significant). In conclusion, a vegan diet tended to be associated with lower, not higher, risk of hypothyroid disease.

  2. Exploratory analysis of Spanish energetic mining accidents.

    Science.gov (United States)

    Sanmiquel, Lluís; Freijo, Modesto; Rossell, Josep M

    2012-01-01

    Using data on work accidents and annual mining statistics, the paper studies work-related accidents in the Spanish energetic mining sector in 1999-2008. The following 3 parameters are considered: age, experience and size of the mine (in number of workers) where the accident took place. The main objective of this paper is to show the relationship between different accident indicators: risk index (as an expression of the incidence), average duration index for the age and size of the mine variables (as a measure of the seriousness of an accident), and the gravity index for the various sizes of mines (which measures the seriousness of an accident, too). The conclusions of this study could be useful to develop suitable prevention policies that would contribute towards a decrease in work-related accidents in the Spanish energetic mining industry.

  3. HAWC and Solar Energetic Transient Events

    Science.gov (United States)

    Lara, A.; Ryan, J. M.

    2013-12-01

    The High Altitude Water Cherenkov (HAWC) observatory is being constructed at the volcano Sierra Negra (4100 m a.s.l.) in Mexico. HAWC's primary purpose is the study of both galactic and extra-galactic sources of high energy gamma rays. The HAWC instrument will consist of 300 large water Cherenkov detectors whose counting rate will be sensitive to cosmic rays with energies above the geomagnetic cutoff of the site ( ˜ 8 GV). In particular, HAWC will detect solar energetic particles known as Ground Level Enhancements (GLEs), and the effect of Coronal Mass Ejections on the galactic cosmic rays, known as Forbush Decreases (FDs). The Milagro experiment, the HAWC predecessor, successfully observed GLEs and the HAWC engineering array "VAMOS" already observed a FD. HAWC will be sensitive to γ rays and neutrons produced during large solar flares. In this work, we present the instrument and discuss its capability to observe solar energetic events. i. e., flares and CMEs.

  4. Energetic protons from a disappearing solar filament

    Energy Technology Data Exchange (ETDEWEB)

    Kahler, S.W.; Cliver, E.W.; Cane, R.E.; McGuire, H.V.; Stone, R.G.

    1985-01-01

    A solar energetic (E> 50MeV) particle (SEP) event observed at 1 AU began about 1500 UT on 1981 December 5. This event was associated with a fast coronal mass ejection observed with the Solwind coronagraph on the P78-1 satellite. No metric type II or type IV burst was observed, but a weak interplanetary type II burst was observed with the low-frequency radio experimentation ISEE-3 satellite. The mass ejection was associated with the eruption of a large solar quiescent filament that lay well away from any active regions. The eruption resulted in a H-alpha double-ribbon structure which straddled the magnetic inversion line. No impulsive phase was obvious in either the H-alpha or the microwave observations. The event indicates that neither a detectable impulsive phase nor a strong or complex magnetic field is necessary for the production of energetic ions.

  5. Assessment of CRBR core disruptive accident energetics

    Energy Technology Data Exchange (ETDEWEB)

    Theofanous, T.G.; Bell, C.R.

    1984-03-01

    The results of an independent assessment of core disruptive accident energetics for the Clinch River Breeder Reactor are presented in this document. This assessment was performed for the Nuclear Regulatory Commission under the direction of the CRBR Program Office within the Office of Nuclear Reactor Regulation. It considered in detail the accident behavior for three accident initiators that are representative of three different classes of events; unprotected loss of flow, unprotected reactivity insertion, and protected loss of heat sink. The primary system's energetics accommodation capability was realistically, yet conservatively, determined in terms of core events. This accommodation capability was found to be equivalent to an isentropic work potential for expansion to one atmosphere of 2550 MJ or a ramp rate of about 200 $/s applied to a classical two-phase disassembly.

  6. Mitochondrial network energetics in the heart.

    Science.gov (United States)

    Aon, Miguel A; Cortassa, Sonia

    2012-01-01

    At the core of eukaryotic aerobic life, mitochondrial function like 'hubs' in the web of energetic and redox processes in cells. In the heart, these networks-extending beyond the complex connectivity of biochemical circuit diagrams and apparent morphology-exhibit collective dynamics spanning several spatiotemporal levels of organization, from the cell, to the tissue, and the organ. The network function of mitochondria, i.e., mitochondrial network energetics, represents an advantageous behavior. Its coordinated action, under normal physiology, provides robustness despite failure in a few nodes, and improves energy supply toward a swiftly changing demand. Extensive diffuse loops, encompassing mitochondrial-cytoplasmic reaction/transport networks, control and regulate energy supply and demand in the heart. Under severe energy crises, the network behavior of mitochondria and associated glycolytic and other metabolic networks collapse, thereby triggering fatal arrhythmias.

  7. Energetics of nearby stellar bow shocks

    CERN Document Server

    Benaglia, Paula

    2012-01-01

    The latest survey of stellar bow shocks (Peri et al. 2012) lists 28 candidates detected at IR wavelengths, associated with massive, early-type stars up to 3 kpc, along with the geometrical parameters of the structures found. I present here some considerations on the energetics involved, after the estimation of stellar wind power, infrared flux, stellar bolometric luminosity and radio flux limits for each source. The best candidates for relativistic particle acceleration are highlighted.

  8. Energetic particle instabilities in fusion plasmas

    CERN Document Server

    Sharapov, S E; Berk, H L; Borba, D N; Breizman, B N; Challis, C D; Classen, I G J; Edlund, E M; Eriksson, J; Fasoli, A; Fredrickson, E D; Fu, G Y; Garcia-Munoz, M; Gassner, T; Ghantous, K; Goloborodko, V; Gorelenkov, N N; Gryaznevich, M P; Hacquin, S; Heidbrink, W W; Hellesen, C; Kiptily, V G; Kramer, G J; Lauber, P; Lilley, M K; Lisak, M; Nabais, F; Nazikian, R; Nyqvist, R; Osakabe, M; von Thun, C Perez; Pinches, S D; Podesta, M; Porkolab, M; Shinohara, K; Schoepf, K; Todo, Y; Toi, K; Van Zeeland, M A; Voitsekhovich, I; White, R B; Yavorskij, V; TG, ITPA EP; Contributors, JET-EFDA

    2013-01-01

    Remarkable progress has been made in diagnosing energetic particle instabilities on present-day machines and in establishing a theoretical framework for describing them. This overview describes the much improved diagnostics of Alfven instabilities and modelling tools developed world-wide, and discusses progress in interpreting the observed phenomena. A multi-machine comparison is presented giving information on the performance of both diagnostics and modelling tools for different plasma conditions outlining expectations for ITER based on our present knowledge.

  9. New Trends in Research of Energetic Materials

    Science.gov (United States)

    2007-11-02

    and university teachers working in the field of teaching , research, development, processing, analyzing and application of all kinds of energetic...the University of Pardubice. The original purpose of these meetings was to teach young research workers how to present their results in front of...carbon by nitrogen gives them improved thermochemistry , it also increases their oxygen balance and reduces their aromatic stabilisation energy. Both

  10. The energetic alpha particle transport method EATM

    Energy Technology Data Exchange (ETDEWEB)

    Kirkpatrick, R.C.

    1998-02-01

    The EATM method is an evolving attempt to find an efficient method of treating the transport of energetic charged particles in a dynamic magnetized (MHD) plasma for which the mean free path of the particles and the Larmor radius may be long compared to the gradient lengths in the plasma. The intent is to span the range of parameter space with the efficiency and accuracy thought necessary for experimental analysis and design of magnetized fusion targets.

  11. Electron correlations and silicon nanocluster energetics

    OpenAIRE

    2016-01-01

    The first-principle prediction of nanocluster stable structure is often hampered by the existence of many isomer configurations with energies close to the ground state. This fact attaches additional importance to many-electron effects going beyond density functional theory (DFT), because their contributions may change a subtle energy order of competitive structures. To analyze this problem, we consider, as an example, the energetics of silicon nanoclusters passivated by hydrogen Si$_{10}$H$_{...

  12. Molecular and Cellular Signaling

    CERN Document Server

    Beckerman, Martin

    2005-01-01

    A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases ...

  13. Energetic particle investigation using the ERNE instrument

    Directory of Open Access Journals (Sweden)

    J. Torsti

    Full Text Available During solar flares and coronal mass ejections, nuclei and electrons accelerated to high energies are injected into interplanetary space. These accelerated particles can be detected at the SOHO satellite by the ERNE instrument. From the data produced by the instrument, it is possible to identify the particles and to calculate their energy and direction of propagation. Depending on variable coronal/interplanetary conditions, different kinds of effects on the energetic particle transport can be predicted. The problems of interest include, for example, the effects of particle properties (mass, charge, energy, and propagation direction on the particle transport, the particle energy changes in the transport process, and the effects the energetic particles have on the solar-wind plasma. The evolution of the distribution function of the energetic particles can be measured with ERNE to a better accuracy than ever before. This gives us the opportunity to contribute significantly to the modeling of interplanetary transport and acceleration. Once the acceleration/transport bias has been removed, the acceleration-site abundance of elements and their isotopes can be studied in detail and compared with spectroscopic observations.

  14. Energetic Particles Dynamics in Mercury's Magnetosphere

    Science.gov (United States)

    Walsh, Brian M.; Ryou, A.S.; Sibeck, D. G.; Alexeev, I. I.

    2013-01-01

    We investigate the drift paths of energetic particles in Mercury's magnetosphere by tracing their motion through a model magnetic field. Test particle simulations solving the full Lorentz force show a quasi-trapped energetic particle population that gradient and curvature drift around the planet via "Shabansky" orbits, passing though high latitudes in the compressed dayside by equatorial latitudes on the nightside. Due to their large gyroradii, energetic H+ and Na+ ions will typically collide with the planet or the magnetopause and will not be able to complete a full drift orbit. These simulations provide direct comparison for recent spacecraft measurements from MESSENGER. Mercury's offset dipole results in an asymmetric loss cone and therefore an asymmetry in particle precipitation with more particles precipitating in the southern hemisphere. Since the planet lacks an atmosphere, precipitating particles will collide directly with the surface of the planet. The incident charged particles can kick up neutrals from the surface and have implications for the formation of the exosphere and weathering of the surface

  15. Fundamental energetic limits of radio communication systems

    Science.gov (United States)

    Baudais, Jean-Yves

    2017-02-01

    The evaluation of the energy consumption of a radiocommunication requires to analyse the life cycle of the elements used. However, this analysis does not specify the energetic limits. Theoretical approaches allow one to draw these limits, which are known in multiple cases of information transmission. However, the answers are not always satisfactory, in particular in the case of time-varying channels. After a brief presentation of the notion of energetic limits of a radiocommunication, and beginning with a global approach, we show that, contrary to the published results, the energetic limits always differ from zero if the physical constraints are correctly expressed. xml:lang="fr" Cependant, les réponses ne sont pas toujours satisfaisantes, particulièrement dans le cas de canaux variants dans le temps. Après une rapide présentation des notions d'énergie limite d'une radiocommunication, et en commençant par une approche globale du problème, nous montrons que, contrairement aux résultats publiés, les limites énergétiques sont toujours différentes de zéro si les contraintes physiques sont correctement exprimées.

  16. Radiation Hydrodynamics Modeling of Hohlraum Energetics

    Science.gov (United States)

    Patel, Mehul V.; Mauche, Christopher W.; Jones, Ogden S.; Scott, Howard A.

    2015-11-01

    Attempts to model the energetics in NIF Hohlraums have been made with varying degrees of success, with discrepancies of 0-25% being reported for the X-ray flux (10-25% for the NIC ignition platform hohlraums). To better understand the cause(s) of these discrepancies, the effects of uncertainties in modeling thermal conduction, laser-plasma interactions, atomic mixing at interfaces, and NLTE kinetics of the high-Z wall plasma must be quantified. In this work we begin by focusing on the NLTE kinetics component. We detail a simulation framework for developing an integrated HYDRA hohlraum model with predefined tolerances for energetics errors due to numerical discretization errors or statistical fluctuations. Within this framework we obtain a model for a converged 1D spherical hohlraum which is then extended to 2D. The new model is used to reexamine physics sensitivities and improve estimates of the energetics discrepancy. Prepared by LLNL under Contract DE-AC52-07NA27344.

  17. Highly Energetic, Low Sensitivity Aromatic Peroxy Acids.

    Science.gov (United States)

    Gamage, Nipuni-Dhanesha H; Stiasny, Benedikt; Stierstorfer, Jörg; Martin, Philip D; Klapötke, Thomas M; Winter, Charles H

    2016-02-18

    The synthesis, structure, and energetic materials properties of a series of aromatic peroxy acid compounds are described. Benzene-1,3,5-tris(carboperoxoic) acid is a highly sensitive primary energetic material, with impact and friction sensitivities similar to those of triacetone triperoxide. By contrast, benzene-1,4-bis(carboperoxoic) acid, 4-nitrobenzoperoxoic acid, and 3,5-dinitrobenzoperoxoic acid are much less sensitive, with impact and friction sensitivities close to those of the secondary energetic material 2,4,6-trinitrotoluene. Additionally, the calculated detonation velocities of 3,5-dinitrobenzoperoxoic acid and 2,4,6-trinitrobenzoperoxoic acid exceed that of 2,4,6-trinitrotoluene. The solid-state structure of 3,5-dinitrobenzoperoxoic acid contains intermolecular O-H⋅⋅⋅O hydrogen bonds and numerous N⋅⋅⋅O, C⋅⋅⋅O, and O⋅⋅⋅O close contacts. These attractive lattice interactions may account for the less sensitive nature of 3,5-dinitrobenzoperoxoic acid.

  18. Sol-Gel Manufactured Energetic Materials

    Science.gov (United States)

    Simpson, Randall L.; Lee, Ronald S.; Tillotson, Thomas M.; Hrubesh, Lawrence W.; Swansiger, Rosalind W.; Fox, Glenn A.

    2005-05-17

    Sol-gel chemistry is used for the preparation of energetic materials (explosives, propellants and pyrotechnics) with improved homogeneity, and/or which can be cast to near-net shape, and/or made into precision molding powders. The sol-gel method is a synthetic chemical process where reactive monomers are mixed into a solution, polymerization occurs leading to a highly cross-linked three dimensional solid network resulting in a gel. The energetic materials can be incorporated during the formation of the solution or during the gel stage of the process. The composition, pore, and primary particle sizes, gel time, surface areas, and density may be tailored and controlled by the solution chemistry. The gel is then dried using supercritical extraction to produce a highly porous low density aerogel or by controlled slow evaporation to produce a xerogel. Applying stress during the extraction phase can result in high density materials. Thus, the sol-gel method can be used for precision detonator explosive manufacturing as well as producing precision explosives, propellants, and pyrotechnics, along with high power composite energetic materials.

  19. Calculation of the energetics of chemical reactions

    Energy Technology Data Exchange (ETDEWEB)

    Dunning, T.H. Jr.; Harding, L.B.; Shepard, R.L.; Harrison, R.J.

    1988-01-01

    To calculate the energetics of chemical reactions we must solve the electronic Schroedinger equation for the molecular conformations of importance for the reactive encounter. Substantial changes occur in the electronic structure of a molecular system as the reaction progresses from reactants through the transition state to products. To describe these changes, our approach includes the following three elements: the use of multiconfiguration self-consistent field wave functions to provide a consistent zero-order description of the electronic structure of the reactants, transition state, and products; the use of configuration interaction techniques to describe electron correlation effects needed to provide quantitative predictions of the reaction energetics; and the use of large, optimized basis sets to provide the flexibility needed to describe the variations in the electronic distributions. With this approach we are able to study reactions involving as many as 5--6 atoms with errors of just a few kcal/mol in the predicted reaction energetics. Predictions to chemical accuracy, i.e., to 1 kcal/mol or less, are not yet feasible, although continuing improvements in both the theoretical methodology and computer technology suggest that this will soon be possible, at least for reactions involving small polyatomic species. 4 figs.

  20. Environment Aware Cellular Networks

    KAUST Repository

    Ghazzai, Hakim

    2015-02-01

    The unprecedented rise of mobile user demand over the years have led to an enormous growth of the energy consumption of wireless networks as well as the greenhouse gas emissions which are estimated currently to be around 70 million tons per year. This significant growth of energy consumption impels network companies to pay huge bills which represent around half of their operating expenditures. Therefore, many service providers, including mobile operators, are looking for new and modern green solutions to help reduce their expenses as well as the level of their CO2 emissions. Base stations are the most power greedy element in cellular networks: they drain around 80% of the total network energy consumption even during low traffic periods. Thus, there is a growing need to develop more energy-efficient techniques to enhance the green performance of future 4G/5G cellular networks. Due to the problem of traffic load fluctuations in cellular networks during different periods of the day and between different areas (shopping or business districts and residential areas), the base station sleeping strategy has been one of the main popular research topics in green communications. In this presentation, we present several practical green techniques that provide significant gains for mobile operators. Indeed, combined with the base station sleeping strategy, these techniques achieve not only a minimization of the fossil fuel consumption but also an enhancement of mobile operator profits. We start with an optimized cell planning method that considers varying spatial and temporal user densities. We then use the optimal transport theory in order to define the cell boundaries such that the network total transmit power is reduced. Afterwards, we exploit the features of the modern electrical grid, the smart grid, as a new tool of power management for cellular networks and we optimize the energy procurement from multiple energy retailers characterized by different prices and pollutant

  1. Adaptive capacity to bacterial diet modulates aging in C. elegans.

    Science.gov (United States)

    Pang, Shanshan; Curran, Sean P

    2014-02-04

    Diet has a substantial impact on cellular metabolism and physiology. Animals must sense different food sources and utilize distinct strategies to adapt to diverse diets. Here we show that Caenorhabditis elegans lifespan is regulated by their adaptive capacity to different diets, which is controlled by alh-6, a conserved proline metabolism gene. alh-6 mutants age prematurely when fed an Escherichia coli OP50 but not HT115 diet. Remarkably, this diet-dependent aging phenotype is determined by exposure to food during development. Mechanistically, the alh-6 mutation triggers diet-induced mitochondrial defects and increased generation of ROS, likely due to accumulation of its substrate 1-pyrroline-5-carboxylate. We also identify that neuromedin U receptor signaling is essential for diet-induced mitochondrial changes and premature aging. Moreover, dietary restriction requires alh-6 to induce longevity. Collectively, our data reveal a homeostatic mechanism that animals employ to cope with potential dietary insults and uncover an example of lifespan regulation by dietary adaptation.

  2. Diet-induced thermogenesis and satiety in humans after full-fat and reduced-fat meals.

    NARCIS (Netherlands)

    Westerterp-Plantenga, M.S.; Wijckmans-Duijsens, N.E.; Verboeket-van de Venne, W.P.; Graaf, de K.; Weststrate, J.A.; Hof, van het K.H.

    1997-01-01

    Diet-induced thermogenesis was measured during and after a full-fat lunch, an identical but reduced-fat, reduced-energy lunch, and an iso-energetic reduced-fat lunch in 32 normal-weight men and women, age 35-55. Hunger and satiety were scored during and after the lunches, and their relationship to d

  3. Mammalian energetics. Flexible energetics of cheetah hunting strategies provide resistance against kleptoparasitism.

    Science.gov (United States)

    Scantlebury, David M; Mills, Michael G L; Wilson, Rory P; Wilson, John W; Mills, Margaret E J; Durant, Sarah M; Bennett, Nigel C; Bradford, Peter; Marks, Nikki J; Speakman, John R

    2014-10-03

    Population viability is driven by individual survival, which in turn depends on individuals balancing energy budgets. As carnivores may function close to maximum sustained power outputs, decreased food availability or increased activity may render some populations energetically vulnerable. Prey theft may compromise energetic budgets of mesopredators, such as cheetahs and wild dogs, which are susceptible to competition from larger carnivores. We show that daily energy expenditure (DEE) of cheetahs was similar to size-based predictions and positively related to distance traveled. Theft at 25% only requires cheetahs to hunt for an extra 1.1 hour per day, increasing DEE by just 12%. Therefore, not all mesopredators are energetically constrained by direct competition. Other factors that increase DEE, such as those that increase travel, may be more important for population viability.

  4. Mammalian energetics. Instantaneous energetics of puma kills reveal advantage of felid sneak attacks.

    Science.gov (United States)

    Williams, Terrie M; Wolfe, Lisa; Davis, Tracy; Kendall, Traci; Richter, Beau; Wang, Yiwei; Bryce, Caleb; Elkaim, Gabriel Hugh; Wilmers, Christopher C

    2014-10-03

    Pumas (Puma concolor) live in diverse, often rugged, complex habitats. The energy they expend for hunting must account for this complexity but is difficult to measure for this and other large, cryptic carnivores. We developed and deployed a physiological SMART (species movement, acceleration, and radio tracking) collar that used accelerometry to continuously monitor energetics, movements, and behavior of free-ranging pumas. This felid species displayed marked individuality in predatory activities, ranging from low-cost sit-and-wait behaviors to constant movements with energetic costs averaging 2.3 times those predicted for running mammals. Pumas reduce these costs by remaining cryptic and precisely matching maximum pouncing force (overall dynamic body acceleration = 5.3 to 16.1g) to prey size. Such instantaneous energetics help to explain why most felids stalk and pounce, and their analysis represents a powerful approach for accurately forecasting resource demands required for survival by large, mobile predators.

  5. Cellular communication through light.

    Directory of Open Access Journals (Sweden)

    Daniel Fels

    Full Text Available Information transfer is a fundamental of life. A few studies have reported that cells use photons (from an endogenous source as information carriers. This study finds that cells can have an influence on other cells even when separated with a glass barrier, thereby disabling molecule diffusion through the cell-containing medium. As there is still very little known about the potential of photons for intercellular communication this study is designed to test for non-molecule-based triggering of two fundamental properties of life: cell division and energy uptake. The study was performed with a cellular organism, the ciliate Paramecium caudatum. Mutual exposure of cell populations occurred under conditions of darkness and separation with cuvettes (vials allowing photon but not molecule transfer. The cell populations were separated either with glass allowing photon transmission from 340 nm to longer waves, or quartz being transmittable from 150 nm, i.e. from UV-light to longer waves. Even through glass, the cells affected cell division and energy uptake in neighboring cell populations. Depending on the cuvette material and the number of cells involved, these effects were positive or negative. Also, while paired populations with lower growth rates grew uncorrelated, growth of the better growing populations was correlated. As there were significant differences when separating the populations with glass or quartz, it is suggested that the cell populations use two (or more frequencies for cellular information transfer, which influences at least energy uptake, cell division rate and growth correlation. Altogether the study strongly supports a cellular communication system, which is different from a molecule-receptor-based system and hints that photon-triggering is a fine tuning principle in cell chemistry.

  6. Cellular automata: structures

    OpenAIRE

    Ollinger, Nicolas

    2002-01-01

    Jury : François Blanchard (Rapporteur), Marianne Delorme (Directeur), Jarkko Kari (Président), Jacques Mazoyer (Directeur), Dominique Perrin, Géraud Sénizergues (Rapporteur); Cellular automata provide a uniform framework to study an important problem of "complex systems" theory: how and why do system with a easily understandable -- local -- microscopic behavior can generate a more complicated -- global -- macroscopic behavior? Since its introduction in the 40s, a lot of work has been done to ...

  7. Engineering Cellular Metabolism

    DEFF Research Database (Denmark)

    Nielsen, Jens; Keasling, Jay

    2016-01-01

    Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds...... of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation....

  8. Failover in cellular automata

    CERN Document Server

    Kumar, Shailesh

    2010-01-01

    A cellular automata (CA) configuration is constructed that exhibits emergent failover. The configuration is based on standard Game of Life rules. Gliders and glider-guns form the core messaging structure in the configuration. The blinker is represented as the basic computational unit, and it is shown how it can be recreated in case of a failure. Stateless failover using primary-backup mechanism is demonstrated. The details of the CA components used in the configuration and its working are described, and a simulation of the complete configuration is also presented.

  9. The New Nordic Diet

    DEFF Research Database (Denmark)

    Micheelsen, Arun

    This PhD project is part of the research programme at the OPUS Research Centre (2009-2013) at the University of Copenhagen. The aim of the Centre is to improve public health in Denmark by developing, testing and disseminating the New Nordic Diet (NND). Combining the gastronomic ideals of the New...... Nordic Cuisine movement with eating habits that accord with Nordic dietary recommendations, the NND is designed to be a healthy, Nordic, seasonal and organic diet that will be acceptable to Danish consumers. This PhD study has four objectives: (i) to explore the acceptance of the NND among Danish......: (iv) to assess which social and cultural factors are likely to impact upon the achievement of the aim of OPUS. The NND concept was found to be well accepted, although some consumers viewed it as being an elitist diet. Also, the taste of the NND was very well accepted. The practical hallenges and time...

  10. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...... with vitamins A, C and E and beta-carotene offers no protection against the development of lung cancer. On the contrary, beta-carotene supplementation has, in two major randomised intervention trials, resulted in an increased mortality. Smoking remains the leading cause of lung cancer. The adverse effects...

  11. Vegetarian diets and children.

    Science.gov (United States)

    Sanders, T A

    1995-08-01

    Although the general health and development of vegan and vegetarian children seem to be normal, there may be subtle differences compared with omnivores. They are at increased risk of iron deficiency, and impaired psychomotor development associated with iron deficiency has been reported in macrobiotic infants. Fortunately, this impairment is not permanent, and follow-up studies have reported higher-than-average intelligence quotients among older macrobiotic children. Several other hazards of vegetarian diets have been identified, including vitamin B12 deficiency, rickets, and a bulky diet that can restrict energy intake in the first few years of life; however, these pitfalls can be avoided easily, and children can be successfully reared on vegetarian diets.

  12. Cellular antioxidant activity of common vegetables.

    Science.gov (United States)

    Song, Wei; Derito, Christopher M; Liu, M Keshu; He, Xiangjiu; Dong, Mei; Liu, Rui Hai

    2010-06-01

    The measurement of antioxidant activity using biologically relevant assays is important to screen fruits, vegetables, natural products, and dietary supplements for potential health benefits. The cellular antioxidant activity (CAA) assay quantifies antioxidant activity using a cell culture model and was developed to meet the need for a more biologically representative method than the popular chemistry antioxidant capacity measures. The objective of the study was to determine the CAA, total phenolic contents, and oxygen radical absorbance capacity (ORAC) values of 27 vegetables commonly consumed in the United States. Beets, broccoli, and red pepper had the highest CAA values, whereas cucumber had the lowest. CAA values were significantly correlated to total phenolic content. Potatoes were found to be the largest contributors of vegetable phenolics and CAA to the American diet. Increased fruit and vegetable consumption is an effective strategy to increase antioxidant intake and decrease oxidative stress and may lead to reduced risk of developing chronic diseases, such as cancer and cardiovascular disease.

  13. Vegan Diets and Hypothyroidism

    Directory of Open Access Journals (Sweden)

    Serena Tonstad

    2013-11-01

    Full Text Available Diets eliminating animal products have rarely been associated with hypothyroidism but may protect against autoimmune disease. Thus, we investigated whether risk of hypothyroidism was associated with vegetarian compared to omnivorous dietary patterns. The Adventist Health Study-2 was conducted among church members in North America who provided data in a self-administered questionnaire. Hypothyroidism was queried at baseline in 2002 and at follow-up to 2008. Diet was examined as a determinant of prevalent (n = 4237 of 65,981 [6.4%] and incident cases (1184 of 41,212 [2.9%] in multivariate logistic regression models, controlled for demographics and salt use. In the prevalence study, in addition to demographic characterstics, overweight and obesity increased the odds (OR 1.32, 95% CI: 1.22–1.42 and 1.78, 95% CI: 1.64–1.93, respectively. Vegan versus omnivorous diets tended to be associated with reduced risk (OR 0.89, 95% CI: 0.78–1.01, not statistically significant while a lacto-ovo diet was associated with increased risk (OR 1.09, 95% CI: 1.01–1.18. In the incidence study, female gender, white ethnicity, higher education and BMI were predictors of hypothyroidism. Following a vegan diet tended to be protective (OR 0.78, 95% CI: 0.59–1.03, not statistically significant. In conclusion, a vegan diet tended to be associated with lower, not higher, risk of hypothyroid disease.

  14. An Ag(I) energetic metal-organic framework assembled with the energetic combination of furazan and tetrazole: synthesis, structure and energetic performance.

    Science.gov (United States)

    Qu, Xiao-Ni; Zhang, Sheng; Wang, Bo-Zhou; Yang, Qi; Han, Jing; Wei, Qing; Xie, Gang; Chen, San-Ping

    2016-04-28

    A novel Ag(I) energetic MOF [Ag16(BTFOF)9]n·[2(NH4)]n () assembled with Ag(iI ions and a furazan derivative, 4,4'-oxybis[3,3'-(1H-5-tetrazol)]furazan (H2BTFOF) was successfully synthesized and structurally characterized, featuring a three-dimensional porous structure incorporating ammonium cations. The thermal stability and energetic properties were determined, revealing that the 3D energetic MOF had an outstanding insensitivity (IS > 40 J), an ultrahigh detonation pressure (P) of 65.29 GPa and a detonation velocity (D) of 11.81 km cm(-3). In addition, the self-accelerating decomposition temperature (TSADT) and the critical temperature of thermal explosion (Tb) are also discussed in detail. The finding exemplifies that the assembly strategy plays a decisive role in the density and energetic properties of MOF-based energetic materials.

  15. Solar Energetic Particle Studies with PAMELA

    Science.gov (United States)

    Bravar, U.; Christian, E. R.; deNolfo, Georgia; Ryan, J. M.; Stochaj, S.

    2011-01-01

    The origin of the high-energy solar energetic particles (SEPs) may conceivably be found in composition signatures that reflect the elemental abundances of the low corona and chromosphere vs. the high corona and solar wind. The presence of secondaries, such as neutrons and positrons, could indicate a low coronal origin of these particles. Velocity dispersion of different species and over a wide energy range can be used to determine energetic particle release times at the Sun. Together with multi-wavelength imaging, in- situ observations of a variety of species, and coverage over a wide energy range provide a critical tool in identifying the origin of SEPs, understanding the evolution of these events within the context of solar active regions, and constraining the acceleration mechanisms at play. The Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA)instrument, successfully launched in 2006 and expected to remain operational until at least the beginning of 2012, measures energetic particles in the same energy range as ground-based neutron monitors, and lower energies as well. It thus bridges the gap between low energy in-situ observations and ground-based Ground Level Enhancements (GLE) observations. It can measure the charge (up to Z=6) and atomic number of the detected particles, and it can identify and measure positrons and detect neutrons-an unprecedented array of data channels that we can bring to bear on the origin of high-energy SEPs. We present prelimiary results on the for the 2006 December 13 solar flare and GLE and the 2011 March 21 solar flare, both registering proton and helium enhancements in PAMELA. Together with multi- spacecraft contextual data and modeling, we discuss the PAMELA results in the context of the different acceleration mechanisms at play.

  16. Dose spectra from energetic particles and neutrons

    Science.gov (United States)

    Schwadron, Nathan; Bancroft, Chris; Bloser, Peter; Legere, Jason; Ryan, James; Smith, Sonya; Spence, Harlan; Mazur, Joe; Zeitlin, Cary

    2013-10-01

    spectra from energetic particles and neutrons (DoSEN) are an early-stage space technology research project that combines two advanced complementary radiation detection concepts with fundamental advantages over traditional dosimetry. DoSEN measures not only the energy but also the charge distribution (including neutrons) of energetic particles that affect human (and robotic) health in a way not presently possible with current dosimeters. For heavy ions and protons, DoSEN provides a direct measurement of the lineal energy transfer (LET) spectra behind shielding material. For LET measurements, DoSEN contains stacks of thin-thick Si detectors similar in design to those used for the Cosmic Ray Telescope for the Effects of Radiation. With LET spectra, we can now directly break down the observed spectrum of radiation into its constituent heavy-ion components and through biologically based quality factors that provide not only doses and dose rates but also dose equivalents, associated rates, and even organ doses. DoSEN also measures neutrons from 10 to 100 MeV, which requires enough sensitive mass to fully absorb recoil particles that the neutrons produce. DoSEN develops the new concept of combining these independent measurements and using the coincidence of LET measurements and neutron detection to significantly reduce backgrounds in each measurement. The background suppression through the use of coincidence allows for significant reductions in size, mass, and power needed to provide measurements of dose, neutron dose, dose equivalents, LET spectra, and organ doses. Thus, we introduce the DoSEN concept: a promising low-mass instrument that detects the full spectrum of energetic particles, heavy ions, and neutrons to determine biological impact of radiation in space.

  17. Synthesis of a new energetic nitrate ester

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, David E [Los Alamos National Laboratory

    2008-01-01

    Nitrate esters have been known as useful energetic materials since the discovery of nitroglycerin by Ascanio Sobrero in 1846. The development of methods to increase the safety and utility of nitroglycerin by Alfred Nobel led to the revolutionary improvement in the utility of nitroglycerin in explosive applications in the form of dynamite. Since then, many nitrate esters have been prepared and incorporated into military applications such as double-based propellants, detonators and as energetic plasticizers. Nitrate esters have also been shown to have vasodilatory effects in humans and thus have been studied and used for treatments of ailments such as angina. The mechanism of the biological response towards nitrate esters has been elucidated recently. Interestingly, many of the nitrate esters used for military purposes are liquids (ethylene glycol dinitrate, propylene glycol dinitrate, etc). Pentaerythritol tetranitrate (PETN) is one of the only solid nitrate esters, besides nitrocellulose, that is used in any application. Unfortunately, PETN melting point is above 100 {sup o}C, and thus must be pressed as a solid for detonator applications. A more practical material would be a melt-castable explosive, for potential simplification of manufacturing processes. Herein we describe the synthesis of a new energetic nitrate ester (1) that is a solid at ambient temperatures, has a melting point of 85-86 {sup o}C and has the highest density of any known nitrate ester composed only of carbon, hydrogen, nitrogen and oxygen. We also describe the chemical, thermal and sensitivity properties of 1 as well as some preliminary explosive performance data.

  18. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.

    Directory of Open Access Journals (Sweden)

    David N Ruskin

    Full Text Available The ketogenic diet is a high-fat, low-carbohydrate regimen that forces ketone-based rather than glucose-based cellular metabolism. Clinically, maintenance on a ketogenic diet has been proven effective in treating pediatric epilepsy and type II diabetes, and recent basic research provides evidence that ketogenic strategies offer promise in reducing brain injury. Cellular mechanisms hypothesized to be mobilized by ketone metabolism and underlying the success of ketogenic diet therapy, such as reduced reactive oxygen species and increased central adenosine, suggest that the ketolytic metabolism induced by the diet could reduce pain and inflammation. To test the effects of a ketone-based metabolism on pain and inflammation directly, we fed juvenile and adult rats a control diet (standard rodent chow or ketogenic diet (79% fat ad libitum for 3-4 weeks. We then quantified hindpaw thermal nociception as a pain measure and complete Freund's adjuvant-induced local hindpaw swelling and plasma extravasation (fluid movement from the vasculature as inflammation measures. Independent of age, maintenance on a ketogenic diet reduced the peripheral inflammatory response significantly as measured by paw swelling and plasma extravasation. The ketogenic diet also induced significant thermal hypoalgesia independent of age, shown by increased hindpaw withdrawal latency in the hotplate nociception test. Anti-inflammatory and hypoalgesic diet effects were generally more robust in juveniles. The ketogenic diet elevated plasma ketones similarly in both age groups, but caused slowed body growth only in juveniles. These data suggest that applying a ketogenic diet or exploiting cellular mechanisms associated with ketone-based metabolism offers new therapeutic opportunities for controlling pain and peripheral inflammation, and that such a metabolic strategy may offer significant benefits for children and adults.

  19. Complex Nanostructures: Synthesis and Energetic Applications

    Directory of Open Access Journals (Sweden)

    Dunwei Wang

    2010-02-01

    Full Text Available Connected through single crystalline junctions, low dimensional materials such as nanowires and nanorods form complex nanostructures. These new materials exhibit mechanical strengths and electrical conductivities superior to their constituents while maintaining comparable surface areas, an attribute ideal for energetic applications. More efficient solar cells, higher capacity batteries and better performing photoelectrochemical cells have been built using these materials. This article reviews this exciting new class of materials and covers topics from controlled syntheses to applications in photovoltaics, chemical energy conversion and electrical charge storage. Mechanisms responsible for the improved performance are discussed. The prospect of their applications in a broader energy-related field is analyzed.

  20. Energetics of Synchronization in Coupled Oscillators

    CERN Document Server

    Izumida, Yuki; Seifert, Udo

    2016-01-01

    We formulate the energetics of synchronization in coupled oscillators by unifying the nonequilibrium aspects with the nonlinear dynamics via stochastic thermodynamics. We derive a concise and universal expression of the energy dissipation rate using nonlinear-dynamics quantities characterizing synchronization, and elucidate how synchronization/desynchronization between the oscillators affects it. We apply our theory to hydrodynamically-coupled Stokes spheres rotating on circular trajectories that may be interpreted as the simplest model of synchronization of coupled oscillators in a biological system, revealing that the oscillators gain the ability to do more work on the surrounding fluid as the degree of phase synchronization increases.

  1. The Energetic Particle Experiment (EPE) on THOR

    Science.gov (United States)

    Wimmer-Schweingruber, Robert; Vainio, Rami; Steinhagen, Jan

    2016-07-01

    THOR is one of the remaining three candidate mission for ESA's M4 launch in 2026. The Energetic Particle Experiment (EPE) will measure electrons (ions) from 20 keV (20 keV/nuc) to 700 keV (20 MeV) with excellent pitch-angle resolution and a very high cadence. This will allow us to understand how turbulence dissipates and how particles are energized in this process, thus shedding light on this ubiquitous astrophysical process. We will present the design and current status of EPE.

  2. Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients

    DEFF Research Database (Denmark)

    Riecke, B.F.; Christensen, R.; Christensen, Pia

    2010-01-01

    OBJECTIVES: To evaluate in a prospective, randomized clinical trial (RCT), symptom response among obese knee osteoarthritis (OA) patients following a feasible, intensive weight-loss program for 16 weeks. METHODS: Eligible patients were obese [body mass index (BMI)>30kg/m(2)]; >50 years old......-energetic diet consisting of normal food plus meal replacements (1200kcal/day). The primary endpoint was the number of patients responding according to the Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) responder criterion. The statistical......% body weight in both diet groups, with a pooled estimate of 74% (95%CI: 68-80%). CONCLUSION: No clinically significant differences were found between the 415kcal/day and 810kcal/day diets. A 16-week formula-diet weight-loss program resulted in a fast and effective weight loss with very few adverse...

  3. Nanostructured energetic materials using sol-gel methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Tillotson, T M; Simpson, R L; Hrubesh, L W; Gash, A E; Thomas, I M; Poco, J F

    2000-09-27

    The fundamental differences between energetic composites and energetic materials made from a monomolecular approach are the energy density attainable and the energy release rates. For the past 4 years, we have been exploiting sol-gel chemistry as a route to process energetic materials on a microstructural scale. At the last ISA conference, we described four specific sol-gel approaches to fabricating energetic materials and presented our early work and results on two methods - solution crystallization and powder addition. Here, we detail our work on a third approach, energetic nanocomposites. Synthesis of thermitic types of energetic nanocomposites are presented using transition and main group metal-oxide skeletons. Results on characterization of structure and performance will also be given.

  4. Environmentally compatible next generation green energetic materials (GEMs).

    Science.gov (United States)

    Talawar, M B; Sivabalan, R; Mukundan, T; Muthurajan, H; Sikder, A K; Gandhe, B R; Rao, A Subhananda

    2009-01-30

    This paper briefly reviews the literature work reported on the environmentally compatible green energetic materials (GEMs) for defence and space applications. Currently, great emphasis is laid in the field of high-energy materials (HEMs) to increase the environmental stewardship along with the deliverance of improved performance. This emphasis is especially strong in the areas of energetic materials, weapon development, processing, and disposal operations. Therefore, efforts are on to develop energetic materials systems under the broad concept of green energetic materials (GEMs) in different schools all over the globe. The GEMs program initiated globally by different schools addresses these challenges and establishes the framework for advances in energetic materials processing and production that promote compliance with environmental regulations. This review also briefs the principles of green chemistry pertaining to HEMs, followed by the work carried out globally on environmentally compatible green energetic materials and allied ingredients.

  5. Evolution of the gut microbiota and the influence of diet.

    Science.gov (United States)

    Rothe, M; Blaut, M

    2013-03-01

    Diet is a major force that shapes the composition and activity of the gut microbiota. This is evident from alterations in gut microbiota composition after weaning or drastic dietary changes. Owing to the complexity of the microbiota, interactions of intestinal bacteria with the host are difficult to study. Gnotobiotic animal models offer the opportunity to reduce the complexity and the interindividual variability of the intestinal microbiota. Germ-free animals were associated with a simplified microbial community consisting of eight bacterial species, that are found in the human gut. These microbes were selected because their genome sequences are available, and they mimic to some extent the metabolic activity of the human gut microbiota. The microbiota responded to dietary modifications by changes in the relative proportions of the community members. This model offers the chance to better define the role of intestinal bacteria in obesity development, but little is known on how diet affects intestinal bacteria at the cellular level. Mice monoassociated with Escherichia coli were used as a simplified model to investigate the influence of dietary factors on bacterial protein expression in the intestine. The mice were fed three different diets: a carbohydrate (lactose)-rich diet, a protein-rich diet and a diet rich in starch. The lactose-rich diet led to an induction of proteins involved in E. coli's oxidative stress response (Fur, AhpF, Dps). The corresponding genes are under control of the OxyR transcriptional regulator which is activated by oxidative stress. Further experiments demonstrated that osmotic stress exerted by various carbohydrates leads to an upregulation of proteins belonging to the oxyR regulon. The data suggest that the upregulated proteins enable intestinal E. coli to better cope with diet-induced osmotic stress. These examples demonstrate that gnotobiotic animal models are a valuable tool for studying diet-induced changes at the community and the

  6. Studies of yeast cell oxygenation and energetics by laser fluorometry of reduced nicotinamide adenine dinucleotide

    Science.gov (United States)

    Pan, Fu-shih; Chen, Stephen; Mintzer, Robert A.; Chen, Chin-Tu; Schumacker, Paul

    1991-03-01

    It is of fundamental importance for biological scientists to assess cellular energetics. Under aerobic conditions, the tricarboxylic acid cycle (TCA cycle) is coupled with the mitochondrial electron cascade pathway to provide the cell with energy. The nicotinamide adenine dinucleotide-conjugated pair (NAD and NADH) is the coenzyme in numerous important biomedical reactions which include several important dehydrogenase reactions in the TCA cycle. Based on Le Chatelier's principle, NADH will accumulate when this energy production mechanism is impaired. The relative amounts of NAD and NADH in a cell are defined as the redox state of the cell (Williamson et.al. 1967) which provides a valuable index of cellular energetics. The sum of the amounts of NAD and NADH in a cell may be assumed to be constant during a finite time; therefore, a reliable means of measuring the NADH concentration would provide us with a useful indicator of tissue viability. Traditionally, the quantities of NADH and NAD may be measured by chemical assay methods. We can avoid these tediois analyses by exploiting the significant difference between the ultraviolet absorption spectra of this redox pair. However, because of the opacity of biological samples and the interference of other biochemicals that also absorb ultraviolet radiation, measurement of NADH and NAD+ concentrations in vivo by absorption spectroscopy is not feasible.

  7. Biocidal Energetic Materials for the Destruction of Spore Forming Bacteria

    Science.gov (United States)

    2015-07-01

    L R E P O R T DTRA-TR-13-52 Biocidal Energetic Materials for the Destruction of Spore Forming Bacteria Distribution Statement A...Z39.18 00-07-2015 Technical N/A Biocidal Energetic Materials for the Destruction of Spore Forming Bacteria HDTRA1-10-1-0108 Emily M. Hunt, Ph.D. West...understand the interaction between spore forming bacteria and thermite reactions and products and to exploit energetic material reactions with

  8. High Strain Rate Experiments of Energetic Material Binder

    OpenAIRE

    Rangel Mendoza, Roberto; Harr, Michael; Chen, Weinong

    2016-01-01

    Energetic materials, in particular HMX, is widely used in many applications as polymer bonded explosives (PBX) and rocket propellant. However, when damaged, HMX is known to be an unstable substance which renders it a hazardous material and in some cases unreliable. Finding critical mechanical conditions at high rates that render various forms of energetic materials as unreliable would be vital to understand the effects that vibrations and compression forces have on energetic materials. A bett...

  9. Energetics of hydrogen bonding in proteins: a model compound study.

    OpenAIRE

    1996-01-01

    Differences in the energetics of amide-amide and amide-hydroxyl hydrogen bonds in proteins have been explored from the effect of hydroxyl groups on the structure and dissolution energetics of a series of crystalline cyclic dipeptides. The calorimetrically determined energetics are interpreted in light of the crystal structures of the studied compounds. Our results indicate that the amide-amide and amide-hydroxyl hydrogen bonds both provide considerable enthalpic stability, but that the amide-...

  10. Diet and Exercise

    Science.gov (United States)

    ... Transplant recipients need to be aware of the important role of a healthy diet and exercise plan in ... Living donation increases the existing organ supply. It's important to get to know your transplant team. I am looking for >> About organ allocation About ...

  11. [Glycotoxins and cellular dysfunction. A new mechanism for understanding the preventive effects of lifestyle modifications].

    Science.gov (United States)

    Michalsen, A; Bierhaus, A; Nawroth, P P; Dobos, G J

    2006-08-01

    Recently the AGE-RAGE interaction was identified as a potential mechanism underlying chronic and inflammatory diseases like atherosclerosis, diabetes mellitus and kidney disease. Advanced glycation end products (AGEs) are the derivatives of glucose-protein or glucose-lipid reactions and are mainly generated from the diet (depending on intensity of heating, cooking time and oxygenation). Binding of AGEs or other ligands to the AGE receptor (RAGE) results in cellular activation, i.e. increased expression of inflammatory mediators and oxidative stress. Diet-derived AGEs thus induce deleterious effects on tissues and the cardiovascular system. Recent research also found that other lifestyle factors are associated with pronounced inflammatory activation, e.g. psychosocial stress and smoking. In addition, each intake of meals is associated with proinflammatory cellular changes. The AGE-RAGE model and investigations of the underlying cellular mechanisms thus may lead to a better understanding of the health benefits of diets (Mediterranean diet, uncooked vegetarian diets), caloric restriction and intermittent fasting. The clinical impact of low-AGE diets and fasting and the interaction between stress and food intake should be further investigated in controlled trials.

  12. Switching Back to Normal Diet Following High-Fat Diet Feeding Reduces Cardiac Vulnerability to Ischaemia and Reperfusion Injury

    OpenAIRE

    Ben Littlejohns; Hua Lin; Gianni D Angelini; Halestrap, Andrew P.; M. Saadeh Suleiman

    2014-01-01

    Background: We have recently shown that hearts of mice fed high-fat diet exhibit increased vulnerability to ischaemia and reperfusion (I/R) in parallel to changes in catalase protein expression, mitochondrial morphology and intracellular diastolic Ca2+. Aims: To determine whether switching from high-fat back to normal diet alters vulnerability to I/R and to investigate cardiac cellular remodelling in relation to the mechanism(s) underlying I/R injury. Methods and Results: Male C57BL/6J mice w...

  13. Hepatitis C: Diet and Nutrition

    Science.gov (United States)

    ... with Hepatitis » Daily Living: Diet and Nutrition Viral Hepatitis Menu Menu Viral Hepatitis Viral Hepatitis Home For ... have high cholesterol and have fatty liver. How hepatitis C affects diet If you have hepatitis, you ...

  14. Diet History Questionnaire: Suggested Citations

    Science.gov (United States)

    Use of the Diet History Questionnaire and Diet*Calc Analysis Software for publication purposes should contain a citation which includes version information for the software, questionnaire, and nutrient database.

  15. Cellular image classification

    CERN Document Server

    Xu, Xiang; Lin, Feng

    2017-01-01

    This book introduces new techniques for cellular image feature extraction, pattern recognition and classification. The authors use the antinuclear antibodies (ANAs) in patient serum as the subjects and the Indirect Immunofluorescence (IIF) technique as the imaging protocol to illustrate the applications of the described methods. Throughout the book, the authors provide evaluations for the proposed methods on two publicly available human epithelial (HEp-2) cell datasets: ICPR2012 dataset from the ICPR'12 HEp-2 cell classification contest and ICIP2013 training dataset from the ICIP'13 Competition on cells classification by fluorescent image analysis. First, the reading of imaging results is significantly influenced by one’s qualification and reading systems, causing high intra- and inter-laboratory variance. The authors present a low-order LP21 fiber mode for optical single cell manipulation and imaging staining patterns of HEp-2 cells. A focused four-lobed mode distribution is stable and effective in optical...

  16. Multiuser Cellular Network

    CERN Document Server

    Bao, Yi; Chen, Ming

    2011-01-01

    Modern radio communication is faced with a problem about how to distribute restricted frequency to users in a certain space. Since our task is to minimize the number of repeaters, a natural idea is enlarging coverage area. However, coverage has restrictions. First, service area has to be divided economically as repeater's coverage is limited. In this paper, our fundamental method is to adopt seamless cellular network division. Second, underlying physics content in frequency distribution problem is interference between two close frequencies. Consequently, we choose a proper frequency width of 0.1MHz and a relevantly reliable setting to apply one frequency several times. We make a few general assumptions to simplify real situation. For instance, immobile users yield to homogenous distribution; repeaters can receive and transmit information in any given frequency in duplex operation; coverage is mainly decided by antenna height. Two models are built up to solve 1000 users and 10000 users situations respectively....

  17. Engineering Cellular Metabolism.

    Science.gov (United States)

    Nielsen, Jens; Keasling, Jay D

    2016-03-10

    Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals. However, making cells into efficient factories is challenging because cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways that resist efforts to divert resources. Here, we will review the current status and challenges of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation.

  18. Multidimensional DDT modeling of energetic materials

    Energy Technology Data Exchange (ETDEWEB)

    Baer, M.R.; Hertel, E.S.; Bell, R.L.

    1995-07-01

    To model the shock-induced behavior of porous or damaged energetic materials, a nonequilibrium mixture theory has been developed and incorporated into the shock physics code, CTH. The foundation for this multiphase model is based on a continuum mixture formulation given by Baer and Nunziato. This multiphase mixture model provides a thermodynamic and mathematically-consistent description of the self-accelerated combustion processes associated with deflagration-to-detonation and delayed detonation behavior which are key modeling issues in safety assessment of energetic systems. An operator-splitting method is used in the implementation of this model, whereby phase diffusion effects are incorporated using a high resolution transport method. Internal state variables, forming the basis for phase interaction quantities, are resolved during the Lagrangian step requiring the use of a stiff matrix-free solver. Benchmark calculations are presented which simulate low-velocity piston impact on a propellant porous bed and experimentally-measured wave features are well replicated with this model. This mixture model introduces micromechanical models for the initiation and growth of reactive multicomponent flow that are key features to describe shock initiation and self-accelerated deflagration-to-detonation combustion behavior. To complement one-dimensional simulation, two-dimensional numerical calculations are presented which indicate wave curvature effects due to the loss of wall confinement. This study is pertinent for safety analysis of weapon systems.

  19. The Energetics of Gravity Driven Faulting

    Science.gov (United States)

    Barrows, L.

    2007-12-01

    Faulting can result from either of two different mechanisms. These involve fundamentally different energetics. In displacement-bounded faulting, locked-in elastic strain energy is transformed into seismic waves plus work done in the fault zone. Elastic rebound is an example of displacement-bounded faulting. In force-driven faulting, the forces that create the stress on the fault supply work or energy to the faulting process. Half of this energy is transformed into seismic waves plus work done in the fault zone and half goes into an increase in locked-in elastic strain. In displacement-bounded faulting the locked-in elastic strain drives slip on the fault. In force-driven faulting it stops slip on the fault. Tectonic stress is reasonably attributed to gravity acting on topography and the Earth's lateral density variations. This includes the thermal convection that ultimately drives plate tectonics. The gravity collapse seismic mechanism assumes the fault fails and slips in direct response to the gravitational tectonic stress. Gravity collapse is an example of force-driven faulting. In the simplest case, energy that is released from the gravitational potential of the topography and internal stress-causing density variations is equally split between the seismic waves plus work done in the fault zone and the increase in locked-in elastic strain. The release of gravitational potential energy requires a change in the Earth's density distribution. Gravitational body forces are solely dependent on density so a change in the density distribution requires a change in the body forces. This implies the existence of volumetric body-force displacements. The volumetric body-force displacements are in addition to displacements generated by slip on the fault. They must exist if gravity participates in the energetics of the faulting process. From the perspective of gravitational tectonics, the gravity collapse mechanism is direct and simple. The related mechanics are a little more

  20. DEVELOPMENT OF AN INTERACTIVE SOFTWARE TO STUDY ENERGETIC METABOLISM

    Directory of Open Access Journals (Sweden)

    Emanuella da Silva Cardoso

    2016-11-01

    Full Text Available INTRODUCTION: Technology allows the creation of dynamic interfaces and graphics, which enables the construction of different scenarios that simulate biochemical events at cellular and molecular level. Furthermore, games have the ability to amuse and stimulate students and thus keeping them interested and receptive. Therefore, digital games must be explored as teaching aids once they have features that enhance the teaching process. OBJECTIVES: This project aimed to develop an educational software that contributes to the understanding of various events taking place in energetic metabolism. MATERIALS AND METHODS: We developed a downloadable educational game in Java, divided into two levels, each of which tackle issues about the Krebs cycle, the respiratory chain and oxidative phosphorylation. Initially, the names of the components of the metabolic process appear randomly on computer screen and the user must follow clues to place them in the right sequence, until all the biochemical reactions are complete. In next phase, there is a quiz about details and clinical correlates related to the theme of the game. Finally, students have to answer a form in order to verify acceptance and relevance of the game. DISCUSSION AND RESULTS: The game was applied to 40 medical students from UFF. The game’s subject matter and its difficulty were analyzed and more than 40% of students classified both respiratory chain and Krebs cycle as difficult. These findings highlight the need to establish new methods to enhance the teaching and learning processes and decrease the students’ difficulties, which is the game’s purpose. The game was very highly rated by students once they evaluated the game as an excellent educational aid and 92% of students agreed that it complements the content discussed in classroom. Finally, 97,5% of students said they would play again. CONCLUSION: Therefore, educational games could be an excellent tool to optimize learning.

  1. An Algorithmic Diversity Diet?

    DEFF Research Database (Denmark)

    Sørensen, Jannick Kirk; Schmidt, Jan-Hinrik

    2016-01-01

    With the growing influence of personalized algorithmic recommender systems on the exposure of media content to users, the relevance of discussing the diversity of recommendations increases, particularly as far as public service media (PSM) is concerned. An imagined implementation of a diversity...... diet system however triggers not only the classic discussion of the reach – distinctiveness balance for PSM, but also shows that ‘diversity’ is understood very differently in algorithmic recommender system communities than it is editorially and politically in the context of PSM. The design...... of a diversity diet system generates questions not just about editorial power, personal freedom and techno-paternalism, but also about the embedded politics of recommender systems as well as the human skills affiliated with PSM editorial work and the nature of PSM content....

  2. My New Diet

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    正I liked eat fast food before.But it was not healthy,so I changed my diet.Now let me tell you something about my new diet.At 6:30 a.m.,I have breakfast at home.For breakfast,I often eat an egg,some bread and a glass of milk.At 11:30 a.m.,I have lunch at school.I usually have a bowl of rice,some meat and vegetables,sometimes I eat some fish.I with my family often have supper at home in the evening.I usually eat porridge and some vegetables.Sometimes I eat noodles for supper.After supper,I usually have some fruit.Because I usually eat healthy food now,so I am much healthier than before.

  3. Feed restriction and a diet's caloric value: The influence on the aerobic and anaerobic capacity of rats

    Directory of Open Access Journals (Sweden)

    de Moura Leandro

    2012-03-01

    Full Text Available Abstract Background The influence of feed restriction and different diet's caloric value on the aerobic and anaerobic capacity is unclear in the literature. Thus, the objectives of this study were to determine the possible influences of two diets with different caloric values and the influence of feed restriction on the aerobic (anaerobic threshold: AT and anaerobic (time to exhaustion: Tlim variables measured by a lactate minimum test (LM in rats. Methods We used 40 adult Wistar rats. The animals were divided into four groups: ad libitum commercial Purina® diet (3028.0 Kcal/kg (ALP, restricted commercial Purina® diet (RAP, ad libitum semi-purified AIN-93 diet (3802.7 Kcal/kg (ALD and restricted semi-purified AIN-93 diet (RAD. The animals performed LM at the end of the experiment, 48 h before euthanasia. Comparisons between groups were performed by analysis of variance (p Results At the end of the experiment, the weights of the rats in the groups with the restricted diets were significantly lower than those in the groups with ad libitum diet intakes. In addition, the ALD group had higher amounts of adipose tissue. With respect to energetic substrates, the groups subjected to diet restriction had significantly higher levels of liver and muscle glycogen. There were no differences between the groups with respect to AT; however, the ALD group had lower lactatemia at the AT intensity and higher Tlim than the other groups. Conclusions We conclude that dietary restriction induces changes in energetic substrates and that ad libitum intake of a semi-purified AIN-93 diet results in an increase in adipose tissue, likely reducing the density of the animals in water and favouring their performance during the swimming exercises.

  4. Cellular bioluminescence imaging.

    Science.gov (United States)

    Welsh, David K; Noguchi, Takako

    2012-08-01

    Bioluminescence imaging of live cells has recently been recognized as an important alternative to fluorescence imaging. Fluorescent probes are much brighter than bioluminescent probes (luciferase enzymes) and, therefore, provide much better spatial and temporal resolution and much better contrast for delineating cell structure. However, with bioluminescence imaging there is virtually no background or toxicity. As a result, bioluminescence can be superior to fluorescence for detecting and quantifying molecules and their interactions in living cells, particularly in long-term studies. Structurally diverse luciferases from beetle and marine species have been used for a wide variety of applications, including tracking cells in vivo, detecting protein-protein interactions, measuring levels of calcium and other signaling molecules, detecting protease activity, and reporting circadian clock gene expression. Such applications can be optimized by the use of brighter and variously colored luciferases, brighter microscope optics, and ultrasensitive, low-noise cameras. This article presents a review of how bioluminescence differs from fluorescence, its applications to cellular imaging, and available probes, optics, and detectors. It also gives practical suggestions for optimal bioluminescence imaging of single cells.

  5. Cellular neurothekeoma with melanocytosis.

    Science.gov (United States)

    Wu, Ren-Chin; Hsieh, Yi-Yueh; Chang, Yi-Chin; Kuo, Tseng-Tong

    2008-02-01

    Cellular neurothekeoma (CNT) is a benign dermal tumor mainly affecting the head and neck and the upper extremities. It is characterized histologically by interconnecting fascicles of plump spindle or epithelioid cells with ample cytoplasm infiltrating in the reticular dermis. The histogenesis of CNT has been controversial, although it is generally regarded as an immature counterpart of classic/myxoid neurothekeoma, a tumor with nerve sheath differentiation. Two rare cases of CNT containing melanin-laden cells were described. Immunohistochemical study with NKI/C3, vimentin, epithelial membrane antigen, smooth muscle antigen, CD34, factor XIIIa, collagen type IV, S100 protein and HMB-45 was performed. Both cases showed typical growth pattern of CNT with interconnecting fascicles of epithelioid cells infiltrating in collagenous stroma. One of the nodules contained areas exhibiting atypical cytological features. Melanin-laden epithelioid or dendritic cells were diffusely scattered throughout one nodule, and focally present in the peripheral portion of the other nodule. Both nodules were strongly immunoreactive to NKI/C3 and vimentin, but negative to all the other markers employed. CNT harboring melanin-laden cells may pose diagnostic problems because of their close resemblance to nevomelanocytic lesions and other dermal mesenchymal tumors. These peculiar cases may also provide further clues to the histogenesis of CNT.

  6. Diet and Longevity

    Institute of Scientific and Technical Information of China (English)

    He Bingxian

    2000-01-01

    @@In 1985 the International Natural Medicine Society declared the Hoten area, Xinjiang (a province of China) as one of the areas of most pronounced longevity in the world. Why are there more elderly people in Hoten? There are many factors. On the basis of our many years of research, our claim is that diet is the most important factor. Now I will discuss the following factors to illustrate.

  7. Liquid surface model for carbon nanotube energetics

    DEFF Research Database (Denmark)

    Solov'yov, Ilia; Mathew, Maneesh; Solov'yov, Andrey V.;

    2008-01-01

    an important insight in the energetics and stability of nanotubes of different chirality and might be important for the understanding of nanotube growth process. For the computations we use empirical Brenner and Tersoff potentials and discuss their applicability to the study of carbon nanotubes. From......In the present paper we developed a model for calculating the energy of single-wall carbon nanotubes of arbitrary chirality. This model, which we call as the liquid surface model, predicts the energy of a nanotube with relative error less than 1% once its chirality and the total number of atoms...... are known. The parameters of the liquid surface model and its potential applications are discussed. The model has been suggested for open end and capped nanotubes. The influence of the catalytic nanoparticle, atop which nanotubes grow, on the nanotube stability is also discussed. The suggested model gives...

  8. Utilization of FEP energetics. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Frederking, T.H.K.; Abbassi, P.; Afifi, F.; Khandhar, P.K.; Ono, D.Y.; Chen, W.E.W.

    1987-12-01

    The research and development work on Fountain Effect Pump Systems (FEP systems) has been of interest in the competition between mechanical pumps for He II and FEP units. The latter do not have moving parts. In the course of the work, the energetics have been addressed using one part of a simple four-changes-of-state cycle. One option is the FEP ideal change of state at constant chemical potential (mu). The other option is the two-state sequence mu-P with a d mu=0 state change followed by an isobar. Questions of pump behavior, of flow rate response to temperature difference at the hot end, and related questions of thermodynamic cycle completion and heat transfer have been addressed. Porous media data obtained elucidate differences between vapor-liquid phase separation (VLPS) and Zero Net Mass Transfer (ZNMF).

  9. The Two Sources of Solar Energetic Particles

    CERN Document Server

    Reames, Donald V

    2013-01-01

    Evidence for two different physical mechanisms for acceleration of solar energetic particles (SEPs) arose 50 years ago with radio observations of type III bursts, produced by outward streaming electrons, and type II bursts from coronal and interplanetary shock waves. Since that time we have found that the former are related to "impulsive" SEP events from impulsive flares or jets. Here, resonant stochastic acceleration, related to magnetic reconnection involving open field lines, produces not only electrons but 1000-fold enhancements of 3He/4He and of (Z>50)/O. Alternatively, in "gradual" SEP events, shock waves, driven out from the Sun by coronal mass ejections (CMEs), more democratically sample ion abundances that are even used to measure the coronal abundances of the elements. Sometimes residual impulsive suprathermal ions contribute to the seed population for shock acceleration, complicating the abundance picture, but this process has now been modeled theoretically. Initially, impulsive events define a poi...

  10. Towards coherent control of energetic material initiation

    Energy Technology Data Exchange (ETDEWEB)

    Greenfield, Margo T [Los Alamos National Laboratory; Mcgrane, Shawn D [Los Alamos National Laboratory; Scharff, R Jason [Los Alamos National Laboratory; Moore, David S [Los Alamos National Laboratory

    2009-01-01

    Direct optical initiation (DOI) of energetic materials using coherent control of localized energy deposition requires depositing energy into the material to produce a critical size hot spot, which allows propagation of the reaction and thereby initiation, The hot spot characteristics needed for growth to initiation can be studied using quantum controlled initiation (QCI). Achieving direct quantum controlled initiation (QCI) in condensed phase systems requires optimally shaped ultrafast laser pulses to coherently guide the energy flow along the desired paths. As a test of our quantum control capabilities we have successfully demonstrated our ability to control the reaction pathway of the chemical system stilbene. An acousto-optical modulator based pulse shaper was used at 266 nm, in a shaped pump/supercontinuum probe technique, to enhance and suppress th relative yields of the cis- to trans-stilbene isomerization. The quantum control techniques tested in the stilbene experiments are currently being used to investigate QCI of the explosive hexanitroazobenzene (HNAB).

  11. Energetic Particle Diffusion In Critically Balanced Turbulence

    CERN Document Server

    Laitinen, T; Kelly, J; Marsh, M; 10.1088/0004-637X/764/2/168

    2013-01-01

    Observations and modelling suggest that the fluctuations in magnetised plasmas exhibit scale-dependent anisotropy, with more energy in the fluctuations perpendicular to the mean magnetic field than in the parallel fluctuations and the anisotropy increasing at smaller scales. The scale-dependence of the anisotropy has not been studied in full-orbit simulations of particle transport in turbulent plasmas so far. In this paper, we construct a model of critically balanced turbulence, as suggested by \\cite{GoSr1995}, and calculate energetic particle spatial diffusion coefficients using full-orbit simulations. The model uses an enveloped turbulence approach, where each 2-dimensional wave mode with wavenumber $k_\\perp$ is packed into envelopes of length $L$ following the critical balance condition, $L\\propto k_\\perp^{-2/3}$, with the wave mode parameters changing between envelopes. Using full-orbit particle simulations, we find that both the parallel and perpendicular diffusion coefficients increase by a factor 2, co...

  12. Characterization of thermally degraded energetic materials

    Energy Technology Data Exchange (ETDEWEB)

    Renlund, A.M.; Miller, J.C.; Trott, W.M.; Erickson, K.L.; Hobbs, M.L.; Schmitt, R.G.; Wellman, G.W.; Baer, M.R.

    1997-12-31

    Characterization of the damage state of a thermally degraded energetic material (EM) is a critical first step in understanding and predicting cookoff behavior. Unfortunately, the chemical and mechanical responses of heated EMs are closely coupled, especially if the EM is confined. The authors have examined several EMs in small-scale experiments (typically 200 mg) heated in both constant-volume and constant-load configurations. Fixtures were designed to minimize free volume and to contain gas pressures to several thousand psi. The authors measured mechanical forces or displacements that correlated to thermal expansion, phase transitions, material creep and gas pressurization as functions of temperature and soak time. In addition to these real-time measurements, samples were recovered for postmortem examination, usually with scanning electron microscopy (SEM) and chemical analysis. The authors present results on EMs (HMX and TATB), with binders (e.g., PBX 9501, PBX 9502, LX-14) and propellants (Al/AP/HTPB).

  13. Energetic materials destruction using molten salt

    Energy Technology Data Exchange (ETDEWEB)

    Upadhye, R.S.; Watkins, B.E.; Pruneda, C.O.; Brummond, W.A.

    1994-04-29

    The Lawrence Livermore National Laboratory in conjunction with the Energetic Materials Center is developing methods for the safe and environmentally sound destruction of explosives and propellants as a part of the Laboratory`s ancillary demilitarization mission. LLNL has built a small-scale unit to test the destruction of HE using the Molten Salt Destruction (MSD) Process. In addition to the high explosive HMX, destruction has been carried out on RDX, PETN, ammonium picrate, TNT, nitroguanadine, and TATB. Also destroyed was a liquid gun propellant comprising hydroxyammonium nitrate, triethanolammonium nitrate and water. In addition to these pure components, destruction has been carried out on a number of commonly used formulations, such as LX-10, LX-16, LX-17, and PBX-9404.

  14. Nonlinear Electromagnetic Interactions in Energetic Materials

    CERN Document Server

    Wood, M A; Moore, D S

    2016-01-01

    We study the scattering of electromagnetic waves in anisotropic energetic materials. Nonlinear light-matter interactions in molecular crystals result in frequency-conversion and polarization changes. Applied electromagnetic fields of moderate intensity can induce these nonlinear effects without triggering chemical decomposition, offering a mechanism for non-ionizing identification of explosives. We use molecular dynamics simulations to compute such two-dimensional Raman spectra in the terahertz range for planar slabs made of PETN and ammonium nitrate. We discuss third-harmonic generation and polarization-conversion processes in such materials. These observed far-field spectral features of the reflected or transmitted light may serve as an alternative tool for stand-off explosive detection.

  15. Energetically Modified Cement (EMC) - Performance Mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Ronin, Vladimir; Elfgren, Lennart [Luleaa Univ. of Technology (Sweden). Centre for High Performance Cement

    2003-03-01

    Energetically Modified Cements, EMC, made of intensively milled cement (50%) and fillers (50%) of quartz or fly ash have been compared to blends of Ordinary Portland Cement, OPC, and fillers. The EMCs have better properties than other blends and are comparable to unblended OPC. This remarkable fact can probably be explained as follows. The grinding process reduces the size of both cement grains and fillers. This combined with the creation of micro defects gives the ground cement a very high degree of hydration. The increased early hydration and a better distribution of hydration products results in an extensive pore size refinement of the hardened binder. This pore size refinement leads to a favorably reduced permeability and diffusivity and very good mechanical properties.

  16. Shear initiated reactions in energetic and reactive materials

    NARCIS (Netherlands)

    Meuken, B.; Martinez Pacheco, M.; Verbeek, H.J.; Bouma, R.H.B.; Katgerman, L.

    2006-01-01

    Deformation of energetic materials may cause undesired reactions and therefore hazardous situations. The deformation of an energetic material and in particular shear deformation is studied in this paper. Understanding of the phenomena leading to shear initiation is not only necessary to explain for

  17. Synthesis and Characterization of Mixed Metal Oxide Nanocomposite Energetic Materials

    Energy Technology Data Exchange (ETDEWEB)

    Gash, A; Pantoya, M; Jr., J S; Zhao, L; Shea, K; Simpson, R; Clapsaddle, B

    2003-11-18

    In the field of composite energetic materials, properties such as ingredient distribution, particle size, and morphology, affect both sensitivity and performance. Since the reaction kinetics of composite energetic materials are typically controlled by the mass transport rates between reactants, one would anticipate new and potentially exceptional performance from energetic nanocomposites. We have developed a new method of making nanostructured energetic materials, specifically explosives, propellants, and pyrotechnics, using sol-gel chemistry. A novel sol-gel approach has proven successful in preparing metal oxide/silicon oxide nanocomposites in which the metal oxide is the major component. Two of the metal oxides are tungsten trioxide and iron(III) oxide, both of which are of interest in the field of energetic materials. Furthermore, due to the large availability of organically functionalized silanes, the silicon oxide phase can be used as a unique way of introducing organic additives into the bulk metal oxide materials. As a result, the desired organic functionality is well dispersed throughout the composite material on the nanoscale. By introducing a fuel metal into the metal oxide/silicon oxide matrix, energetic materials based on thermite reactions can be fabricated. The resulting nanoscale distribution of all the ingredients displays energetic properties not seen in its microscale counterparts due to the expected increase of mass transport rates between the reactants. The synthesis and characterization of these metal oxide/silicon oxide nanocomposites and their performance as energetic materials will be discussed.

  18. Energetic materials: crystallization, characterization and insensitive plastic bonded explosives

    NARCIS (Netherlands)

    Heijden, A.E.D.M. van der; Creyghton, Y.L.M.; Marino, E.; Bouma, R.H.B.; Scholtes, G.J.H.G.; Duvalois, W.; Roelands, C.P.M.

    2008-01-01

    The product quality of energetic materials is predominantly determined by the crystallization process applied to produce these materials. It has been demonstrated in the past that the higher the product quality of the solid energetic ingredients, the less sensitive a plastic bonded explosive contain

  19. The minimal energetic requirement of sustained awareness after brain injury

    DEFF Research Database (Denmark)

    Stender, Johan; Mortensen, Kristian Nygaard; Thibaut, Aurore

    2016-01-01

    % of normal cortical activity represents the minimal energetic requirement for the presence of conscious awareness. Overall, the cerebral metabolic rate accounted for the current level, or imminent return, of awareness in 94% of the patient population, suggesting a global energetic threshold effect...

  20. Energetic adaptations persist after bariatric surgery in severely obese adolescents

    Science.gov (United States)

    Energetic adaptations induced by bariatric surgery have not been studied in adolescents or for extended periods postsurgery. Energetic, metabolic, and neuroendocrine responses to Roux-en-Y gastric bypass (RYGB) surgery were investigated in extremely obese adolescents. At baseline and at 1.5, 6, and...

  1. [Diet low in potassium].

    Science.gov (United States)

    Sáez Rodríguez, Loreto; Meizoso Ameneiro, Ana; Pérez Paz, Ma Jesús; Valiño Pazos, Cristina

    2011-11-01

    After confirming the high prevalence rates in our hemodialysis unit of the following nursing diagnoses: nutritional imbalances--both excesses and shortages, willingness to improve nutrition and fear related to the consequences of excessive intake of potassium and manifested by the inhibition in some people towards the enjoyment of food, we decided to plan an educational strategy which later resulted in a nursing intervention for these diagnoses, with the objective of providing adequate resources for the monitoring of balanced diets with a restriction of potassium. Inspired by dietary rations, as well as recognized dietary programs of learning by points, we decided to incorporate these ideas to design an educational tool to facilitate advice to our patients on how to follow diet plans as well as the choice of appropriate foods. The result was a set of cards incorporating nutritional information of various kinds, aimed at our patients covering different aspects of the diet appropriate food rations using household measurements, promoting good food preparation, appropriate dietary advice for different chronic diseases and a scoring system of foods according to their potassium content. Together they form a board game available during the hemodialysis sessions that also takes into consideration other issues of importance related to conditions such as cognitive stimulation, coping with the disease, improving the therapeutic performance or resources to increase patient motivation. Although initially it was only an educational exercise, the result has turned out to be both enjoyable and entertaining.

  2. Acne and diet.

    Science.gov (United States)

    Wolf, Ronni; Matz, Hagit; Orion, Edith

    2004-01-01

    Forbidden foods? "The first law of dietetics seems to be: If it tastes good, it's bad for you" (Isaac Asimov, Russian-born biochemist and science fiction writer). This was essentially the Magna Carta for dermatologists of the 1950s: anything coveted by the teenage palate was suspect for morning after acne. Today, half a century later, although the slant has shifted away for this line of thinking in our dermatologic textbooks, several articles on the beliefs and perceptions of acne patients showed that nothing much has changed and that they expect us to give them detailed instructions of what "acne-related" foods they should avoid. In one such study(1), diet was the third most frequently implicated factor (after hormones and genetics) as the cause of the disease, with 32% of the respondents selecting diet as the main cause, and 44% thinking that foods aggravate acne. In another study that analyzed knowledge about causes of acne among English teenagers, 11% of the responders blamed greasy food as the main cause of the disease(2), whereas in another study found that 41% of final-year medical students of the University of Melbourne chose diet as an important factor of acne exacerbation on a final examination.(3)

  3. Energetic dose: Beyond fire and flint?

    Science.gov (United States)

    Linder, G.; Rattner, B.; Cohen, J.

    2000-01-01

    Nutritional and bioenergetic interactions influence exposure to environmental chemicals and may affect the risk realized when wildlife are exposed in the field. Here, food-chain analysis focuses on prairie voles (Microtus ochrogaster) and the evaluation of chemical risks associated with paraquat following 10-d dietary exposures. Reproductive effects were measured in 60-d trials that followed exposures to paraquat-tainted feed: control (untainted feed); 21 mg paraquat/kg feed; 63 mg paraquat/kg feed; and feed-restricted control (untainted feed restricted to 60% baseline consumption). Reproductive success was evaluated in control and treated breeding pairs, and a preliminary bioenergetics analysis was completed in parallel to derive exposure dose. Although reproductive performance differed among groups, feed-restriction appeared to be the dominant treatment effect observed in these 10-d feeding exposure/limited reproductive trials. Exposure dose ranged from 3.70-3.76 to 9.41-11.51 mg parquat/kg BW/day at 21 and 63 mg paraquat/kg feed stock exposures, respectively. Energetic doses as ug paraquat/kcal yielded preliminary estimates of energetic costs associated with paraquat exposure, and were similar within treatments for both sexes, ranging from 4.2-5.5 and 13.1-15.0 ug paraquat/kcal for voles exposed to 21 mg/kg feed stock and 63 mg/kg feed stock, respectively. Given the increasing likelihood that environmental chemicals will be found in wildlife habitat at 'acceptable levels', the critical role that wildlife nutrition plays in evaluating ecological risks should be fully integrated into the assessment process. Tools applied to the analysis of risk must gain higher resolution than the relatively crude methods we currently bring to the process.

  4. Energetic particle perspective of the magnetopause

    Energy Technology Data Exchange (ETDEWEB)

    Williams, D.J.; Fritz, T.A.; Wilken, B.; Keppler, E.

    1979-11-01

    We present a detailed analysis of energetic (>24 keV) particle data obtained from the Isee satellites during a series of magnetopause crossings which occurred at 0000--0400 hours UT (approx.1030 hours LT) on November 20, 1977. The primary energetic particle data used are the three-dimensional distributions obtained from the Isee A satellite. Correlative magnetic field measurements are used to relate the particle behavior to magnetic field characteristics at and earthward of the magnetopause. We find that to first order the magnetopause can be regarded as a perfectly absorbing boundary for trapped >24-keV particles, that it is nearly alway in motion, and that boundary waves are often present. We find that the observed dayside magnetopause motion is consistent with a large-scale radial motion having an approx.10-min period plus superimposed boundary waves with a 90- to 150-s period. More qualitatively, we find that the data require a third and longer period (approx. 30 min) magnetopause motion upon which the above, shorter-period motions are superimposed. It is concluded that the radial gradient to the magnetopause observed in the directional, >24-keV, dayside, near-equatorial, magnetospherically trapped particle flux is due to internal magnetospheric processes. Just outside the magnetopause in the magnetosheath we observe a broad (approximately hemispherical) field-aligned flow of >24-keV ions away from the magnetosphere. The absolute intensity and spectral characteristics of this flow and its reltion to the magnetopause and the trapped particle population indicate that it is formed by the leakage of trapped particles from the radiation belts onto magnetosheath field lines as their trajectories move to within two gyroradii of the magnetopause.

  5. COAL’S ROLE IN THE WORLD ENERGETIC SYSTEM

    Directory of Open Access Journals (Sweden)

    Andrei ROTH

    2014-06-01

    Full Text Available The world energy needs are on the rise, and they come from developing economies, especially the emerging ones such as China or India with high demographic and economic growth rates. These countries future demand for energy will shape the world’s energetic system. They will require considerable quantities of energy to fuel their demanding economies. The last decade has shown that the world’s energetic needs are being reoriented from West to East. Coal represents an available, secure and competitive energetic resource which can help the growing need for energy. However it is not that flexible as gas or renewables and it has also a greater impact upon environment due to its greenhouse gas emissions in the context of climate change. For these reasons coal is being less used for the energetic needs of the developed economies. Will the current attributes of coal be sufficient to maintain coal’s place in the world energetic mix?

  6. Nanostructured energetic composites: synthesis, ignition/combustion modeling, and applications.

    Science.gov (United States)

    Zhou, Xiang; Torabi, Mohsen; Lu, Jian; Shen, Ruiqi; Zhang, Kaili

    2014-03-12

    Nanotechnology has stimulated revolutionary advances in many scientific and industrial fields, particularly in energetic materials. Powder mixing is the simplest and most traditional method to prepare nanoenergetic composites, and preliminary findings have shown that these composites perform more effectively than their micro- or macro-sized counterparts in terms of energy release, ignition, and combustion. Powder mixing technology represents only the minimum capability of nanotechnology to boost the development of energetic material research, and it has intrinsic limitations, namely, random distribution of fuel and oxidizer particles, inevitable fuel pre-oxidation, and non-intimate contact between reactants. As an alternative, nanostructured energetic composites can be prepared through a delicately designed process. These composites outperform powder-mixed nanocomposites in numerous ways; therefore, we comprehensively discuss the preparation strategies adopted for nanostructured energetic composites and the research achievements thus far in this review. The latest ignition and reaction models are briefly introduced. Finally, the broad promising applications of nanostructured energetic composites are highlighted.

  7. Energetic and nutritional constraints on infant brain development: implications for brain expansion during human evolution.

    Science.gov (United States)

    Cunnane, Stephen C; Crawford, Michael A

    2014-12-01

    The human brain confronts two major challenges during its development: (i) meeting a very high energy requirement, and (ii) reliably accessing an adequate dietary source of specific brain selective nutrients needed for its structure and function. Implicitly, these energetic and nutritional constraints to normal brain development today would also have been constraints on human brain evolution. The energetic constraint was solved in large measure by the evolution in hominins of a unique and significant layer of body fat on the fetus starting during the third trimester of gestation. By providing fatty acids for ketone production that are needed as brain fuel, this fat layer supports the brain's high energy needs well into childhood. This fat layer also contains an important reserve of the brain selective omega-3 fatty acid, docosahexaenoic acid (DHA), not available in other primates. Foremost amongst the brain selective minerals are iodine and iron, with zinc, copper and selenium also being important. A shore-based diet, i.e., fish, molluscs, crustaceans, frogs, bird's eggs and aquatic plants, provides the richest known dietary sources of brain selective nutrients. Regular access to these foods by the early hominin lineage that evolved into humans would therefore have helped free the nutritional constraint on primate brain development and function. Inadequate dietary supply of brain selective nutrients still has a deleterious impact on human brain development on a global scale today, demonstrating the brain's ongoing vulnerability. The core of the shore-based paradigm of human brain evolution proposes that sustained access by certain groups of early Homo to freshwater and marine food resources would have helped surmount both the nutritional as well as the energetic constraints on mammalian brain development.

  8. Effectofsteam-lfakingonchemicalcompositions,starchgelatinization, in vitro fermentability, and energetic values of maize, wheat and rice

    Institute of Scientific and Technical Information of China (English)

    QIAO Fu-qiang; WANG Fei; REN Li-ping; ZHOU Zhen-ming; MENG Qing-xiang; BAO Yu-hong

    2015-01-01

    Intact and steam-lfaked grains of maize, wheat and rice (with whole hulls) were analyzed for chemical composition, starch gelatinization degree (SGD) and in vitro fermentation characteristics to investigate the inlfuence of cereal type and steam-lfaking (SF) processing on their nutritive values. The treatments were arranged in a 3×2 factorial design. Obvious differences (P<0.001) in chemical composition and energetic values were observed among the different cereal types. SGD and gas production (GP) rate was signiifcantly increased (P<0.001) by SF processing. SF processing also increased (P<0.01) the proportion of propionic acid and decreased the acetic:propionic acid ratio in vitro. Steam-lfaking also increased organic matter digestibility and the energetic value of the cereal grains, especially rice. Based on these results, rice probably is more amendable to SF processing than maize and wheat. In conclusion, it is feasible to partially substitute maize grain with wheat or rice in ruminant diets, and steam-lfaking can signiifcantly improve the nutritional value of wheat and rice grains.

  9. Free fall and cellular automata

    Directory of Open Access Journals (Sweden)

    Pablo Arrighi

    2016-03-01

    Full Text Available Three reasonable hypotheses lead to the thesis that physical phenomena can be described and simulated with cellular automata. In this work, we attempt to describe the motion of a particle upon which a constant force is applied, with a cellular automaton, in Newtonian physics, in Special Relativity, and in General Relativity. The results are very different for these three theories.

  10. About Strongly Universal Cellular Automata

    Directory of Open Access Journals (Sweden)

    Maurice Margenstern

    2013-09-01

    Full Text Available In this paper, we construct a strongly universal cellular automaton on the line with 11 states and the standard neighbourhood. We embed this construction into several tilings of the hyperbolic plane and of the hyperbolic 3D space giving rise to strongly universal cellular automata with 10 states.

  11. Reactive Programming of Cellular Automata

    OpenAIRE

    Boussinot, Frédéric

    2004-01-01

    Implementation of cellular automata using reactive programming gives a way to code cell behaviors in an abstract and modular way. Multiprocessing also becomes possible. The paper describes the implementation of cellular automata with the reactive programming language LOFT, a thread-based extension of C. Self replicating loops considered in artificial life are coded to show the interest of the approach.

  12. Assessing Nutritional Parameters of Brown Bear Diets among Ecosystems Gives Insight into Differences among Populations.

    Directory of Open Access Journals (Sweden)

    Claudia López-Alfaro

    Full Text Available Food habit studies are among the first steps used to understand wildlife-habitat relationships. However, these studies are in themselves insufficient to understand differences in population productivity and life histories, because they do not provide a direct measure of the energetic value or nutritional composition of the complete diet. Here, we developed a dynamic model integrating food habits and nutritional information to assess nutritional parameters of brown bear (Ursus arctos diets among three interior ecosystems of North America. Specifically, we estimate the average amount of digestible energy and protein (per kilogram fresh diet content in the diet and across the active season by bears living in western Alberta, the Flathead River (FR drainage of southeast British Columbia, and the Greater Yellowstone Ecosystem (GYE. As well, we estimate the proportion of energy and protein in the diet contributed by different food items, thereby highlighting important food resources in each ecosystem. Bear diets in Alberta had the lowest levels of digestible protein and energy through all seasons, which might help explain the low reproductive rates of this population. The FR diet had protein levels similar to the recent male diet in the GYE during spring, but energy levels were lower during late summer and fall. Historic and recent diets in GYE had the most energy and protein, which is consistent with their larger body sizes and higher population productivity. However, a recent decrease in consumption of trout (Oncorhynchus clarki, whitebark pine nuts (Pinus albicaulis, and ungulates, particularly elk (Cervus elaphus, in GYE bears has decreased the energy and protein content of their diet. The patterns observed suggest that bear body size and population densities are influenced by seasonal availability of protein an energy, likely due in part to nutritional influences on mass gain and reproductive success.

  13. Assessing Nutritional Parameters of Brown Bear Diets among Ecosystems Gives Insight into Differences among Populations.

    Science.gov (United States)

    López-Alfaro, Claudia; Coogan, Sean C P; Robbins, Charles T; Fortin, Jennifer K; Nielsen, Scott E

    2015-01-01

    Food habit studies are among the first steps used to understand wildlife-habitat relationships. However, these studies are in themselves insufficient to understand differences in population productivity and life histories, because they do not provide a direct measure of the energetic value or nutritional composition of the complete diet. Here, we developed a dynamic model integrating food habits and nutritional information to assess nutritional parameters of brown bear (Ursus arctos) diets among three interior ecosystems of North America. Specifically, we estimate the average amount of digestible energy and protein (per kilogram fresh diet) content in the diet and across the active season by bears living in western Alberta, the Flathead River (FR) drainage of southeast British Columbia, and the Greater Yellowstone Ecosystem (GYE). As well, we estimate the proportion of energy and protein in the diet contributed by different food items, thereby highlighting important food resources in each ecosystem. Bear diets in Alberta had the lowest levels of digestible protein and energy through all seasons, which might help explain the low reproductive rates of this population. The FR diet had protein levels similar to the recent male diet in the GYE during spring, but energy levels were lower during late summer and fall. Historic and recent diets in GYE had the most energy and protein, which is consistent with their larger body sizes and higher population productivity. However, a recent decrease in consumption of trout (Oncorhynchus clarki), whitebark pine nuts (Pinus albicaulis), and ungulates, particularly elk (Cervus elaphus), in GYE bears has decreased the energy and protein content of their diet. The patterns observed suggest that bear body size and population densities are influenced by seasonal availability of protein an energy, likely due in part to nutritional influences on mass gain and reproductive success.

  14. MIMO Communication for Cellular Networks

    CERN Document Server

    Huang, Howard; Venkatesan, Sivarama

    2012-01-01

    As the theoretical foundations of multiple-antenna techniques evolve and as these multiple-input multiple-output (MIMO) techniques become essential for providing high data rates in wireless systems, there is a growing need to understand the performance limits of MIMO in practical networks. To address this need, MIMO Communication for Cellular Networks presents a systematic description of MIMO technology classes and a framework for MIMO system design that takes into account the essential physical-layer features of practical cellular networks. In contrast to works that focus on the theoretical performance of abstract MIMO channels, MIMO Communication for Cellular Networks emphasizes the practical performance of realistic MIMO systems. A unified set of system simulation results highlights relative performance gains of different MIMO techniques and provides insights into how best to use multiple antennas in cellular networks under various conditions. MIMO Communication for Cellular Networks describes single-user,...

  15. Chronic Consptipation and Diet

    Directory of Open Access Journals (Sweden)

    Mehmet Ince

    2011-02-01

    Full Text Available Constipation presented a lof of sign-symptoms is not a single disease and a disorder that affect colonic and anorectal function. Constipation is defined as decreased of defecation number by physicians and all of problems relation with defecation by patients. But a accurate and correct defitinition giving base on patophyslogically by Rome III criteria. As patophyslogically, constipation is improved by decreased material that will be reached cecum, decreased motility of colon and multiple results improving defecation disorders. Constipation can be divided irratable bowel syndrome with constipation (normal transit, slow transit constipation and defecation disorders but there is no accurate border in this classification. Neurotransmitters, stress, medical therapies, sleep and meals are association with etiology of constipation. A high fiber diet can reach easily to cecum and prevent constipation. Therefore aim of this review is to stress effect of fiber diet in the first and second type of constipation. Slow transit constipation in 13-15% patients and irratable bowel sendrom with constipation (normal transit in 59% patients has being diagnosed. Seconder causes of constipation can be found with a good history taking from patients. Accurate diagnosis can be find with colon transit time followed by abdominal and pelvic examinitian. Treatment should be begin after correction of seconder causes. It should be recommendation to patients a high fiber diet, exercise, appropriate fluid with medical therapy. Lubiprostone and Tegaserod are used to begin for treatment of slow transit constipation. Laparoscopic surgery is recommened to patients not recoveried by medical therapy. [TAF Prev Med Bull 2011; 10(1.000: 71-76

  16. Environmentally Responsible Energetic Materials: Another Look at the Styphnates

    Science.gov (United States)

    Collins, Adam; Angliss, Timothy; Proud, William

    2009-06-01

    Lead Styphnate (lead 2,4,6-trinitroresorcinate) has many applications as a primary explosive, most notably in priming compositions. Its largest drawback, however, is the toxicity of lead. Heavy metals often feature in primary explosives, providing favourable density, bonding, and reaction products; but, the toxic nature of heavy metals makes these explosives of limited use. Current research efforts are being made to design new energetic materials (such as those based around the 5-nitrotetrazole molecule), but familiar energetics can still be of use. The styphnate anion provides many favourable energetic qualities (such as a ring structure and nitro groups), and while the lead salt has proven its usefulness, other metallic styphnates also provide a range of energetic qualities. This paper reports on ignition thresholds, energetic output, and thermal properties of the following salts of trinitroresorcinol: Barium, Bismuth, Calcium, Copper, Lithium, and Lead. Such information provides a list of characterized energetic materials, but also insight into how metal cations can control measurable energetic effects at the molecular and crystal level.

  17. Ketogenic Diet in Epileptic Encephalopathies

    OpenAIRE

    Suvasini Sharma; Manjari Tripathi

    2013-01-01

    The ketogenic diet is a medically supervised high-fat, low-carbohydrate diet that has been found useful in patients with refractory epilepsy. It has been shown to be effective in treating multiple seizure types and epilepsy syndromes. In this paper, we review the use of the ketogenic diet in epileptic encephalopathies such as Ohtahara syndrome, West syndrome, Dravet syndrome, epilepsy with myoclonic atonic seizures, and Lennox-Gastaut syndrome.

  18. Ketogenic Diet in Epileptic Encephalopathies

    Directory of Open Access Journals (Sweden)

    Suvasini Sharma

    2013-01-01

    Full Text Available The ketogenic diet is a medically supervised high-fat, low-carbohydrate diet that has been found useful in patients with refractory epilepsy. It has been shown to be effective in treating multiple seizure types and epilepsy syndromes. In this paper, we review the use of the ketogenic diet in epileptic encephalopathies such as Ohtahara syndrome, West syndrome, Dravet syndrome, epilepsy with myoclonic atonic seizures, and Lennox-Gastaut syndrome.

  19. Cellular systems biology profiling applied to cellular models of disease.

    Science.gov (United States)

    Giuliano, Kenneth A; Premkumar, Daniel R; Strock, Christopher J; Johnston, Patricia; Taylor, Lansing

    2009-11-01

    Building cellular models of disease based on the approach of Cellular Systems Biology (CSB) has the potential to improve the process of creating drugs as part of the continuum from early drug discovery through drug development and clinical trials and diagnostics. This paper focuses on the application of CSB to early drug discovery. We discuss the integration of protein-protein interaction biosensors with other multiplexed, functional biomarkers as an example in using CSB to optimize the identification of quality lead series compounds.

  20. Internal Transport Barrier Driven by Redistribution of Energetic Ions

    Energy Technology Data Exchange (ETDEWEB)

    K.L. Wong; W.W. Heidbrink; E. Ruskov; C.C. Petty; C.M. Greenfield; R. Nazikian; R. Budny

    2004-11-12

    Alfven instabilities excited by energetic ions are used as a means to reduce the central magnetic shear in a tokamak via redistribution of energetic ions. When the central magnetic shear is low enough, ballooning modes become stable for any plasma pressure gradient and an internal transport barrier (ITB) with a steep pressure gradient can exist. This mechanism can sustain a steady-state ITB as demonstrated by experimental data from the DIII-D tokamak. It can also produce a shear in toroidal and poloidal plasma rotation. Possible application of this technique to use the energetic alpha particles for improvement of burning plasma performance is discussed.

  1. Energetic pathway sampling in a protein interaction domain

    DEFF Research Database (Denmark)

    Hultqvist, Greta; Haq, S. Raza; Punekar, Avinash S.;

    2013-01-01

    The affinity and specificity of protein-ligand interactions are influenced by energetic crosstalk within the protein domain. However, the molecular details of such intradomain allostery are still unclear. Here, we have experimentally detected and computationally predicted interaction pathways...... changes may reshape energetic signaling. The results were analyzed in the context of other members of the PDZ family, which were found to contain distinct interaction pathways for different peptide ligands. The data reveal a fascinating scenario whereby several energetic pathways are sampled within one...

  2. Chemical Conversion of Energetic Materials to Higher Value Products

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, A R; Hsu, P C; Coburn, M D; Schmidt, R D; Pagoria, P F; Lee, G S

    2005-04-19

    The objective of this program is to develop new processes for the disposal of surplus energetic materials. Disposal through open burning/open detonation (OB/OD) is considered less attractive today due to environmental, cost and safety concerns. The use of energetic materials as chemical feedstocks for higher value products can provide environmentally sound and cost-effective alternatives to OB/OD. Our recent studies on the conversion of surplus energetic materials (Explosive D, TNT) to higher value products will be described.

  3. Diet and breast cancer

    Directory of Open Access Journals (Sweden)

    Isabelle Romieu

    2011-10-01

    Full Text Available Both diet and nutrition have been studied in relationship with breast cancer risk, as the great variation among different countries in breast cancer incidence could possibly be explained through the inflammatory and immune response, as well as antioxidant intake, among others.To date, no clear association with diet beyond overweight and weight gain has been found, except for alcohol consumption. Nonetheless, the small number of studies done in middle to low income countries where variability of food intake is wider,is beginning to show interesting results.Tanto la dieta como la nutrición han sido estudiadas en relación con el riesgo de cáncer de mama, dada la gran variación de incidencia de cáncer entre países, y la posibilidad de explicarla a través de la respuesta inflamatoria o inmune, así como ingesta de antioxidantes,entre otros.Hasta la fecha, ninguna asociación clara con la dieta ha sido encontrada, excepto para el consumo de alcohol, más allá del sobrepeso y del incremento de peso. Sin embargo, los estudios que se están realizando en países de mediano a bajo nivel de ingresos, con mayor variabilidad de ingesta de alimentos, comienzan a mostrar resultados interesantes.

  4. The modified Atkins diet.

    Science.gov (United States)

    Kossoff, Eric H; Dorward, Jennifer L

    2008-11-01

    In 2003, a case series was published describing the benefits of a less restrictive ketogenic diet (KD) started as an outpatient without a fast and without any restrictions on calories, fluids, or protein. This "Modified Atkins Diet" (MAD) restricts carbohydrates to 10 g/day (15 g/day in adults) while encouraging high fat foods. Now 5 years later, there have been eight prospective and retrospective studies published on this alternative dietary therapy, both in children as well as adults. In these reports, 45 (45%) have had 50-90% seizure reduction, and 28 (28%) >90% seizure reduction, which is remarkably similar to the traditional KD. This review will discuss basics and tips to best provide the MAD, evidence for its efficacy, suggestions about the role of ketosis in dietary treatment efficacy, and its side effect profile. Lastly, the possible future benefits of this treatment for new-onset seizures, adults, neurologic conditions other than epilepsy, and developing countries of the world will be discussed.

  5. Diet in dermatology: Revisited

    Directory of Open Access Journals (Sweden)

    Kaimal Sowmya

    2010-01-01

    Full Text Available Diet has an important role to play in many skin disorders, and dermatologists are frequently faced with the difficulty of separating myth from fact when it comes to dietary advice for their patients. Patients in India are often anxious about what foods to consume, and what to avoid, in the hope that, no matter how impractical or difficult this may be, following this dictum will cure their disease. There are certain disorders where one or more components in food are central to the pathogenesis, e.g. dermatitis herpetiformis, wherein dietary restrictions constitute the cornerstone of treatment. A brief list, although not comprehensive, of other disorders where diet may have a role to play includes atopic dermatitis, acne vulgaris, psoriasis vulgaris, pemphigus, urticaria, pruritus, allergic contact dermatitis, fish odor syndrome, toxic oil syndrome, fixed drug eruption, genetic and metabolic disorders (phenylketonuria, tyrosinemia, homocystinuria, galactosemia, Refsum′s disease, G6PD deficiency, xanthomas, gout and porphyria, nutritional deficiency disorders (kwashiorkar, marasmus, phrynoderma, pellagra, scurvy, acrodermatitis enteropathica, carotenemia and lycopenemia and miscellaneous disorders such as vitiligo, aphthous ulcers, cutaneous vasculitis and telogen effluvium. From a practical point of view, it will be useful for the dermatologist to keep some dietary information handy to deal with the occasional patient who does not seem to respond in spite of the best, scientific and evidence-based therapy.

  6. [Sustainable diet: history lessons].

    Science.gov (United States)

    Fatati, Giuseppe

    2015-11-01

    Global dietary patterns changed dramatically in the past 50 years, presenting both a boom and a threat to the health and well-being of populations everywhere. We need sustainable diets, with low-input, local and seasonal agro-ecological food productions as well as short distance production-consumption nets for fair trade. The development of a global food system able to guarantee everyone a balanced food intake requires health professionals an awareness and a commitment to increasingly complex education. Dietary changes such as the adherence of to the Mediterranean Dietary Pattern can reduce the environmental footprint and thus the use of natural resources. Increased focus on improving the utilization of freshwater fishes and the correct use of the waters of rivers and lakes should also be encouraged. Cultural heritage, food quality and culinary skills are other key aspects determining sustainable dietary patterns and food security. The Mediterranean street food (Mediterraneità), for intrinsic characteristics, can represent valid model to address the main issues concerning the sustainable food system. The issues of sustainability offer a great opportunity to nutritional science and scientists to play a more central role in the political analysis of future food systems. We are confident that preserve the past helps us understand the present and build for the future, the Mediterranean lifestyle is much more than the Mediterranean diet and, finally, the rivers and the lakes may be our future.

  7. Diet, nutrition, and cancer

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, S.

    1985-01-01

    Evidence pertaining to the role of dietary factors in carcinogenesis comes from both epidemiological studies and laboratory experiments. In 1982, the Committee on Diet, Nutrition, and Cancer of the National Research Council conducted a comprehensive evaluation of this evidence. That assessment as well as recent epidemiological and laboratory investigations suggest that a high fat diet is associated with increased susceptibility to cancer of different sites, particularly the breast and colon, and to a lesser extent, the prostate. Current data permit no definitive conclusions about other dietary macroconstituents including cholesterol, total caloric intake, protein, carbohydrates and total dietary fiber. Specific components of fiber, however, may have a protective effect against colon cancer. In epidemiological studies, frequent consumption of certain fruits and vegetables, especially citrus fruits and carotene-rich and cruciferous vegetables, is associated with a lower incidence of cancers at various sites. The specific components responsible for these effects are not clearly identified, although the epidemiological evidence appears to be most consistent for a protective effect of carotene on lung cancer and less so for vitamins A and C and various cancer sites. The laboratory evidence is most consistent for vitamin A deficiency and enhanced tumorigenesis, and for the ability of various nonnutritive components in cruciferous vegetables to block in-vivo carcinogenesis. The data for minerals and carcinogenesis are extremely limited, although preliminary evidence from both epidemiological and laboratory studies suggests that selenium may protect against overall cancer risk. 402 references.

  8. Large gradual solar energetic particle events

    Science.gov (United States)

    Desai, Mihir; Giacalone, Joe

    2016-12-01

    Solar energetic particles, or SEPs, from suprathermal (few keV) up to relativistic (˜ few GeV) energies are accelerated near the Sun in at least two ways: (1) by magnetic reconnection-driven processes during solar flares resulting in impulsive SEPs, and (2) at fast coronal-mass-ejection-driven shock waves that produce large gradual SEP events. Large gradual SEP events are of particular interest because the accompanying high-energy ({>}10s MeV) protons pose serious radiation threats to human explorers living and working beyond low-Earth orbit and to technological assets such as communications and scientific satellites in space. However, a complete understanding of these large SEP events has eluded us primarily because their properties, as observed in Earth orbit, are smeared due to mixing and contributions from many important physical effects. This paper provides a comprehensive review of the current state of knowledge of these important phenomena, and summarizes some of the key questions that will be addressed by two upcoming missions—NASA’s Solar Probe Plus and ESA’s Solar Orbiter. Both of these missions are designed to directly and repeatedly sample the near-Sun environments where interplanetary scattering and transport effects are significantly reduced, allowing us to discriminate between different acceleration sites and mechanisms and to isolate the contributions of numerous physical processes occurring during large SEP events.

  9. Kinetic transport simulation of energetic particles

    Science.gov (United States)

    Sheng, He; Waltz, R. E.

    2016-05-01

    A kinetic transport code (EPtran) is developed for the transport of the energetic particles (EPs). The EPtran code evolves the EP distribution function in radius, energy, and pitch angle phase space (r, E, λ) to steady state with classical slowing down, pitch angle scattering, as well as radial and energy transport of the injected EPs (neutral beam injection (NBI) or fusion alpha). The EPtran code is illustrated by treating the transport of NBI fast ions from high-n ITG/TEM micro-turbulence and EP driven unstable low-n Alfvén eigenmodes (AEs) in a well-studied DIII-D NBI heated discharge with significant AE central core loss. The kinetic transport code results for this discharge are compared with previous study using a simple EP density moment transport code ALPHA (R.E. Waltz and E.M. Bass 2014 Nucl. Fusion 54 104006). The dominant EP-AE transport is treated with a local stiff critical EP density (or equivalent pressure) gradient radial transport model modified to include energy-dependence and the nonlocal effects EP drift orbits. All previous EP transport models assume that the EP velocity space distribution function is not significantly distorted from the classical ‘no transport’ slowing down distribution. Important transport distortions away from the slowing down EP spectrum are illustrated by a focus on the coefficient of convection: EP energy flux divided by the product of EP average energy and EP particle flux.

  10. Energetics of Solar Coronal Mass Ejections

    CERN Document Server

    Subramanian, P; Subramanian, Prasad; Vourlidas, Angelos

    2007-01-01

    Aims: To investigate if solar coronal mass ejections are driven mainly by coupling to the ambient solar wind, or through the release of internal magnetic energy. Methods: We examine the energetics of 39 flux-rope like coronal mass ejections (CMEs) from the Sun using data in the distance range $\\sim$ 2--20 $R_{{\\o}dot}$ from the Large Angle Spectroscopic Coronograph (LASCO) aboard the Solar and Heliospheric Observatory (SOHO). This comprises a complete sample of the best examples of flux-rope CMEs observed by LASCO in 1996-2001. Results: We find that 69% of the CMEs in our sample experience a clearly identifiable driving power in the LASCO field of view. For these CMEs which are driven, we examine if they might be deriving most of their driving power by coupling to the solar wind. We do not find conclusive evidence in favor of this hypothesis. On the other hand, we find that their internal magnetic energy is a viable source of the required driving power. We have estimated upper and lower limits on the power th...

  11. Neutronization and Energetics of Type Ia Supernovae

    Science.gov (United States)

    Seitenzahl, I. R.; Peng, F.; Townsley, D. M.; Calder, A. C.

    2005-12-01

    Type Ia supernovae are critical distance indicators for cosmology. The lightcurves are powered by the decay of radioactive nickel and cobalt isotopes. The amount of nickel produced in the supernova event depends on the detailed trajectories of the hydrodynamic evolution of the explosion. A key ingredient in numerical simulations of the deflagration phase of Type Ia supernovae is the nuclear flame model. A realistic model must accurately describe the nuclear energy released, the timescale on which the energy release occurs, and the changes in composition that constitute the burning. Once the flame has passed, the hot products of the burning constitute a nuclear statistical equilibrium (NSE) abundance distribution. Since the NSE abundances, and hence derived quantities such as the mean binding energy per nucleon, are functions of the density, temperature and electron fraction, it is important to continuously adjust the NSE state of the ashes during the hydrodynamic evolution of the star. Weak interactions influence the energetics and evolution via the change in degeneracy pressure due to captured electrons, the energy losses carried away by neutrinos, and the readjustment of the NSE state following a change in the electron fraction. We have developed a NSE-based model, which implements these features for a hydrodynamical evolution code.

  12. The energetic characterization of pineapple crown leaves.

    Science.gov (United States)

    Braga, R M; Queiroga, T S; Calixto, G Q; Almeida, H N; Melo, D M A; Melo, M A F; Freitas, J C O; Curbelo, F D S

    2015-12-01

    Energetic characterization of biomass allows for assessing its energy potential for application in different conversion processes into energy. The objective of this study is to physicochemically characterize pineapple crown leaves (PC) for their application in energy conversion processes. PC was characterized according to ASTM E871-82, E1755-01, and E873-82 for determination of moisture, ash, and volatile matter, respectively; the fixed carbon was calculated by difference. Higher heating value was determined by ASTM E711-87 and ash chemical composition was determined by XRF. The thermogravimetric and FTIR analyses were performed to evaluate the thermal decomposition and identify the main functional groups of biomass. PC has potential for application in thermochemical processes, showing high volatile matter (89.5%), bulk density (420.8 kg/m(3)), and higher heating value (18.9 MJ/kg). The results show its energy potential justifying application of this agricultural waste into energy conversion processes, implementing sustainability in the production, and reducing the environmental liabilities caused by its disposal.

  13. Energetic characteristics of transition metal complexes.

    Science.gov (United States)

    Wojewódka, Andrzej; Bełzowski, Janusz; Wilk, Zenon; Staś, Justyna

    2009-11-15

    Ten transition metal nitrate and perchlorate complexes of hydrazine and ethylenediamine were synthesized, namely [Cu(EN)(2)](ClO(4))(2), [Co(EN)(3)](ClO(4))(3), [Ni(EN)(3)](ClO(4))(2), [Hg(EN)(2)](ClO(4))(2), [Cr(N(2)H(4))(3)](ClO(4))(3), [Cd(N(2)H(4))(3)](ClO(4))(2), [Ni(N(2)H(4))(3)](NO(3))(2), [Co(N(2)H(4))(3)](NO(3))(3), [Zn(N(2)H(4))(3)](NO(3))(2), and [Cd(N(2)H(4))(3)](NO(3))(2) based on the lines of the literature reported methods. All of them were tested with applying underwater detonation test and further compared to the typical blasting explosives: RDX, HMX, TNT and PETN. From the above presented complexes [Ni(N(2)H(4))(3)](NO(3))(2) (called NHN) and [Co(N(2)H(4))(3)](NO(3))(3) (called CoHN) are known as primary explosives and can be used as the standard explosives. Explosion parameters, such as shock wave overpressure, shock wave energy equivalent and bubble energy equivalent, were determined. Evaluated energetic characteristics of the tested compounds are comparable to those of the classic high explosives and are even enhanced in some cases.

  14. Energetics, lifestyle, and reproduction in birds.

    Science.gov (United States)

    Sibly, Richard M; Witt, Christopher C; Wright, Natalie A; Venditti, Chris; Jetz, Walter; Brown, James H

    2012-07-03

    Theoretical and empirical studies of life history aim to account for resource allocation to the different components of fitness: survival, growth, and reproduction. The pioneering evolutionary ecologist David Lack [(1968) Ecological Adaptations for Breeding in Birds (Methuen and Co., London)] suggested that reproductive output in birds reflects adaptation to environmental factors such as availability of food and risk of predation, but subsequent studies have not always supported Lack's interpretation. Here using a dataset for 980 bird species (Dataset S1), a phylogeny, and an explicit measure of reproductive productivity, we test predictions for how mass-specific productivity varies with body size, phylogeny, and lifestyle traits. We find that productivity varies negatively with body size and energetic demands of parental care and positively with extrinsic mortality. Specifically: (i) altricial species are 50% less productive than precocial species; (ii) species with female-only care of offspring are about 20% less productive than species with other methods of parental care; (iii) nonmigrants are 14% less productive than migrants; (iv) frugivores and nectarivores are about 20% less productive than those eating other foods; and (v) pelagic foragers are 40% less productive than those feeding in other habitats. A strong signal of phylogeny suggests that syndromes of similar life-history traits tend to be conservative within clades but also to have evolved independently in different clades. Our results generally support both Lack's pioneering studies and subsequent research on avian life history.

  15. Linking energetics and overwintering in temperate insects.

    Science.gov (United States)

    Sinclair, Brent J

    2015-12-01

    Overwintering insects cannot feed, and energy they take into winter must therefore fuel energy demands during autumn, overwintering, warm periods prior to resumption of development in spring, and subsequent activity. Insects primarily consume lipids during winter, but may also use carbohydrate and proteins as fuel. Because they are ectotherms, the metabolic rate of insects is temperature-dependent, and the curvilinear nature of the metabolic rate-temperature relationship means that warm temperatures are disproportionately important to overwinter energy use. This energy use may be reduced physiologically, by reducing the slope or elevation of the metabolic rate-temperature relationship, or because of threshold changes, such as metabolic suppression upon freezing. Insects may also choose microhabitats or life history stages that reduce the impact of overwinter energy drain. There is considerable capacity for overwinter energy drain to affect insect survival and performance both directly (via starvation) or indirectly (for example, through a trade-off with cryoprotection), but this has not been well-explored. Likewise, the impact of overwinter energy drain on growing-season performance is not well understood. I conclude that overwinter energetics provides a useful lens through which to link physiology and ecology and winter and summer in studies of insect responses to their environment.

  16. Temporal Evolution of Solar Energetic Particle Spectra

    Science.gov (United States)

    Doran, Donald J.; Dalla, Silvia

    2016-08-01

    During solar flares and coronal mass ejections, Solar Energetic Particles (SEPs) may be released into the interplanetary medium and near-Earth locations. The energy spectra of SEP events at 1 AU are typically averaged over the entire event or studied in a few snapshots. In this article we analyze the time evolution of the energy spectra of four large selected SEP events using a large number of snapshots. We use a multi-spacecraft and multi-instrument approach for the observations, obtained over a wide SEP energy range. We find large differences in the spectra at the beginning of the events as measured by different instruments. We show that over time, a wave-like structure is observed traveling through the spectra from the highest energies to the lowest energies, creating an "arch" shape that then straightens into a power law later in the event, after times on the order of 10 hours. We discuss the processes that determine SEP intensities and their role in shaping the spectral time evolution.

  17. Reactive thermal waves in energetic materials

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Larry G [Los Alamos National Laboratory

    2009-01-01

    Reactive thermal waves (RTWs) arise in several energetic material applications, including self-propagating high-temperature synthesis (SHS), high explosive cookoff, and the detonation of heterogeneous explosives. In this paper I exmaine ideal RTWs, by which I mean that (1) material motion is neglected, (2) the state dependence of reaction is Arrhenius in the temperature, and (3) the reaction rate is modulated by an arbitrary mass-fraction-based reaction progress function. Numerical simulations demonstrate that one's natural intuition, which is based mainly upon experience with inert materials and which leads one to expect diffusion processes to become relatively slow after a short time period, is invalid for high energy, state-sensitive reactive systems. Instead, theory predicts that RTWs can propagate at very high speeds. This result agrees with estimates for detonating heterogeneous explosives, which indicate that RTWs must spread from hot-spot nucleation sites at rates comparable to the detonation speed in order to produce experimentally-observed reaction zone thicknesses. Using dimensionless scaling and further invoking the high activation energy approximation, I obtain an analytic formula for the steady plane RTW speed from numerical calculations. I then compute the RTW speed for real explosives, and discuss aspects of their behavior.

  18. A Course in Cellular Bioengineering.

    Science.gov (United States)

    Lauffenburger, Douglas A.

    1989-01-01

    Gives an overview of a course in chemical engineering entitled "Cellular Bioengineering," dealing with how chemical engineering principles can be applied to molecular cell biology. Topics used are listed and some key references are discussed. Listed are 85 references. (YP)

  19. Energy Landscape of Cellular Networks

    Science.gov (United States)

    Wang, Jin

    2008-03-01

    Cellular Networks are in general quite robust and perform their biological functions against the environmental perturbations. Progresses have been made from experimental global screenings, topological and engineering studies. However, there are so far few studies of why the network should be robust and perform biological functions from global physical perspectives. In this work, we will explore the global properties of the network from physical perspectives. The aim of this work is to develop a conceptual framework and quantitative physical methods to study the global nature of the cellular network. The main conclusion of this presentation is that we uncovered the underlying energy landscape for several small cellular networks such as MAPK signal transduction network and gene regulatory networks, from the experimentally measured or inferred inherent chemical reaction rates. The underlying dynamics of these networks can show bi-stable as well as oscillatory behavior. The global shapes of the energy landscapes of the underlying cellular networks we have studied are robust against perturbations of the kinetic rates and environmental disturbances through noise. We derived a quantitative criterion for robustness of the network function from the underlying landscape. It provides a natural explanation of the robustness and stability of the network for performing biological functions. We believe the robust landscape is a global universal property for cellular networks. We believe the robust landscape is a quantitative realization of Darwinian principle of natural selection at the cellular network level. It may provide a novel algorithm for optimizing the network connections, which is crucial for the cellular network design and synthetic biology. Our approach is general and can be applied to other cellular networks.

  20. The effect of solar energetic particles on the Martian ionosphere

    Science.gov (United States)

    Darwish, Omar Hussain Al; Lillis, Robert; Fillingim, Matthew; Lee, Christina

    2016-10-01

    The precipitation of Solar Energetic Particles (SEP) into the Martian atmosphere causes several effects, one of the most important of which is ionization. However, the importance of this process to the global structure and dynamics for the Martian ionosphere is currently not well understood. The MAVEN spacecraft carries instrumentation which allow us to examine this process. The Neutral Gas and Ion Mass Spectrometer (NGIMS) measures the densities of planetary ions in the Mars ionosphere (O+,CO2+ and O2+). The Solar Energetic Particle (SEP) detector measures the fluxes of energetic protons and electrons. In this project, we examine the degree to which the density of ions in the Martian ionosphere is affected by the precipitation of energetic particles, under conditions of different SEP ion and electron fluxes and at various solar zenith angles. We will present statistical as well as case studies.

  1. Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Bingke; Martins, Ilídio R.S.; Li, Pilong; Amarasinghe, Gaya K.; Umetani, Junko; Fernandez-Zapico, Martin E.; Billadeau, Daniel D.; Machius, Mischa; Tomchick, Diana R.; Rosen, Michael K. (Mayo); (UTSMC)

    2010-05-12

    Vav proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. They control processes including T cell activation, phagocytosis, and migration of normal and transformed cells. We report the structure and biophysical and cellular analyses of the five-domain autoinhibitory element of Vav1. The catalytic Dbl homology (DH) domain of Vav1 is controlled by two energetically coupled processes. The DH active site is directly, but weakly, inhibited by a helix from the adjacent Acidic domain. This core interaction is strengthened 10-fold by contacts of the calponin homology (CH) domain with the Acidic, pleckstrin homology, and DH domains. This construction enables efficient, stepwise relief of autoinhibition: initial phosphorylation events disrupt the modulatory CH contacts, facilitating phosphorylation of the inhibitory helix and consequent GEF activation. Our findings illustrate how the opposing requirements of strong suppression of activity and rapid kinetics of activation can be achieved in multidomain systems.

  2. Mathematical Modeling of Cellular Metabolism.

    Science.gov (United States)

    Berndt, Nikolaus; Holzhütter, Hermann-Georg

    2016-01-01

    Cellular metabolism basically consists of the conversion of chemical compounds taken up from the extracellular environment into energy (conserved in energy-rich bonds of organic phosphates) and a wide array of organic molecules serving as catalysts (enzymes), information carriers (nucleic acids), and building blocks for cellular structures such as membranes or ribosomes. Metabolic modeling aims at the construction of mathematical representations of the cellular metabolism that can be used to calculate the concentration of cellular molecules and the rates of their mutual chemical interconversion in response to varying external conditions as, for example, hormonal stimuli or supply of essential nutrients. Based on such calculations, it is possible to quantify complex cellular functions as cellular growth, detoxification of drugs and xenobiotic compounds or synthesis of exported molecules. Depending on the specific questions to metabolism addressed, the methodological expertise of the researcher, and available experimental information, different conceptual frameworks have been established, allowing the usage of computational methods to condense experimental information from various layers of organization into (self-) consistent models. Here, we briefly outline the main conceptual frameworks that are currently exploited in metabolism research.

  3. Basal metabolic rate in carnivores is associated with diet after controlling for phylogeny.

    Science.gov (United States)

    Munoz-Garcia, Agusti; Williams, Joseph B

    2005-01-01

    Studies of basal metabolic rate (BMR), the minimum metabolic rate of postabsorptive, inactive endotherms while in their rest phase and thermal neutral zone, have contributed significantly to our understanding of animal energetics. Besides body mass, the main determinant of BMR, researchers have invoked diet and phylogenetic history as important factors that influence BMR, although their relative importance has been controversial. For 58 species within the Carnivora, we tested the hypothesis that BMR is correlated with home range size, a proxy for level of activity, and diet, using conventional least squares regression (CLSR) and regression based on phylogenetic independent contrasts (PIC). Results showed that BMR of Carnivora was positively correlated with home range size after controlling for body mass, regardless of the statistical method employed. We also found that diet and mass-adjusted home range size were correlated. When we simultaneously tested the effect of diet and mass-adjusted home range on mass-adjusted BMR, home range size was insignificant because of its colinearity with diet. Then we eliminated home range size from our model, and diet proved to be significant with both CLSR and PIC. We concluded that species that eat meat have larger home ranges and higher BMR than species that eat vegetable matter. To advance our understanding of the potential mechanisms that might explain our results, we propose the "muscle performance hypothesis," which suggests that selection for different muscle fiber types can account for the differences in BMR observed between meat eaters and vegetarian species within the Carnivora.

  4. Synthesis and Characterization of Mixed Metal Oxide Nanocomposite Energetic Materials

    Energy Technology Data Exchange (ETDEWEB)

    Clapsaddle, B; Gash, A; Plantier, K; Pantoya, M; Jr., J S; Simpson, R

    2004-04-27

    In the field of composite energetic materials, properties such as ingredient distribution, particle size, and morphology affect both sensitivity and performance. Since the reaction kinetics of composite energetic materials are typically controlled by the mass transport rates between reactants, one would anticipate new and potentially exceptional performance from energetic nanocomposites. We have developed a new method of making nanostructured energetic materials, specifically explosives, propellants, and pyrotechnics, using sol-gel chemistry. A novel sol-gel approach has proven successful in preparing metal oxide/silicon oxide nanocomposites in which the metal oxide is the major component. By introducing a fuel metal, such as aluminum, into the metal oxide/silicon oxide matrix, energetic materials based on thermite reactions can be fabricated. Two of the metal oxides are tungsten trioxide and iron(III) oxide, both of which are of interest in the field of energetic materials. In addition, due to the large availability of organically functionalized silanes, the silicon oxide phase can be used as a unique way of introducing organic additives into the bulk metal oxide materials. These organic additives can cause the generation of gas upon ignition of the materials, therefore resulting in a composite material that can perform pressure/volume work. Furthermore, the desired organic functionality is well dispersed throughout the composite material on the nanoscale with the other components, and is therefore subject to the same increased reaction kinetics. The resulting nanoscale distribution of all the ingredients displays energetic properties not seen in its microscale counterparts due to the expected increase of mass transport rates between the reactants. The synthesis and characterization of iron(III) oxide/organosilicon oxide nanocomposites and their performance as energetic materials will be discussed.

  5. Effect of Energetic Ion on Spatial Distribution of Recombining Plasma

    Science.gov (United States)

    Okamoto, A.; Daibo, A.; Kitajima, S.; Kumagai, T.; Takahashi, H.; Takahashi, T.; Tsubota, S.

    Spatial distribution of electron density is considered. By using a one-dimensional recombining plasma model, effects of transient energetic ion flux are investigated. The time response of the system against the transient flux is dominated by the recombination frequency. The magnitude of modification of the spatial distribution is determined by the ratio between the ionization due to the energetic ion and the recombination of the bulk plasma.

  6. THE ENERGETIC AGGREGATION AND RELEASE IN THE HEAVY RAIN REGION

    Institute of Scientific and Technical Information of China (English)

    ZHOU Hai-guang; LIU Hai-tao; LIU Yan-ying

    2006-01-01

    Using the new formula of moist available energy (MAE), the value of the MAE's key terms of three heavy rainfall cases in Guangdong province in 1998 was calculated. The energetic aggregation and energetic discharge are analyzed. It shows that the value of the key terms in the formula appears different feature clearly in the different precipitation period, as well as the function of each term presents in the heavy rain region.

  7. Dissolution Rate of Propellant Energetics from Nitrocellulose Matrices

    Science.gov (United States)

    2012-09-01

    ER D C/ CR R EL T R -1 2 -9 ER-1691 Dissolution Rate of Propellant Energetics from Nitrocellulose Matrices C ol d R eg io n s R es ea...showing the heated edge of the propellant . ER-1691 ERDC/CRREL TR-12-9 September 2012 Dissolution Rate of Propellant Energetics from Nitrocellulose ...unfired propellants , are com- posed of nitrocellulose imbibed with either 2,4-DNT (single-base), nitroglycerin (NG) (double- base) or NG and

  8. Cascaded Soliton Compression of Energetic Femtosecond Pulses at 1030 nm

    DEFF Research Database (Denmark)

    Bache, Morten; Zhou, Binbin

    2012-01-01

    We discuss soliton compression with cascaded second-harmonic generation of energetic femtosecond pulses at 1030 nm. We discuss problems encountered with soliton compression of long pulses and show that sub-10 fs compressed pulses can be achieved.......We discuss soliton compression with cascaded second-harmonic generation of energetic femtosecond pulses at 1030 nm. We discuss problems encountered with soliton compression of long pulses and show that sub-10 fs compressed pulses can be achieved....

  9. Investigations of Novel Energetic Materials to Stabilize Rocket Motors

    Science.gov (United States)

    2002-04-30

    and various additives were developed in the second half of the 20th Century. The earliest such propellants were asphalt -based developed at GALCIT with...Decomposition of Energetic Materials 74. Volatile Metal Isocyanates from Flash Pyrolysis of Metal-NTO and Metal-Picrate Salts and an Application Hypothesis...B. Brill, T. L. Zhang and B. C. Tappan, Thermal Decomposition of Energetic Materials 74. Volatile Metal Isocyanates from Flash Pyrolysis of Metal-NTO

  10. Diet and Nutrition and HIV

    Science.gov (United States)

    ... with HIV/AIDS: Diet and Nutrition--Entire Lesson HIV/AIDS Menu Menu HIV/AIDS HIV/AIDS Home ... code here Enter ZIP code here Living with HIV/AIDS: Diet and Nutrition--Entire Lesson for Veterans ...

  11. Diet Quality of Collegiate Athletes

    Science.gov (United States)

    Webber, Kelly; Stoess, Amanda Ireland; Forsythe, Hazel; Kurzynske, Janet; Vaught, Joy Ann; Adams, Bailey

    2015-01-01

    Background/Objectives: Collegiate athletes generally appear healthy according to weight for height and body fat standards. Despite the fact that there are well known connections between athletic performance and nutrition, little is known about the diets of collegiate athletes. The objective of this study was to determine the diet quality of 138…

  12. Diet Quality and Academic Performance

    Science.gov (United States)

    Florence, Michelle D.; Asbridge, Mark; Veugelers, Paul J.

    2008-01-01

    Background: Although the effects of nutrition on health and school performance are often cited, few research studies have examined the effect of diet quality on the academic performance of children. This study examines the association between overall diet quality and academic performance. Methods: In 2003, 5200 grade 5 students in Nova Scotia,…

  13. Diet-Induced Thermogenesis

    Institute of Scientific and Technical Information of China (English)

    GE Chang-rong; GAO Si-zheng; JIA Jun-jing; Mark Jois

    2008-01-01

    An immense amount of information has now accrued about the factors that influence the increment of heat and the efficiency with which the energy of food is used by different animal species.Heat increment is one of the major factors that decrease the efficiency of energy utilization.In growing animals,the free energy content of the basal ATP requirement is typically about one-third of dietary basal heat production (thermogenesis).Thermogenesis is an evolutionary and biologically significant mechanism for adaptive,homeostatic heat production in animals,including shivering thermogenesis (ST),nonshivefing thermogenesis (NST),diet-induced thermogenesis (DIT),febrile response (fever),and so on.The main focus of this review is on the effect of DIT on energy metabolism.

  14. Artificial Diets for Mosquitoes

    Directory of Open Access Journals (Sweden)

    Kristina K. Gonzales

    2016-12-01

    Full Text Available Mosquito-borne diseases are responsible for more than a million human deaths every year. Modern mosquito control strategies such as sterile insect technique (SIT, release of insects carrying a dominant lethal (RIDL, population replacement strategies (PR, and Wolbachia-based strategies require the rearing of large numbers of mosquitoes in culture for continuous release over an extended period of time. Anautogenous mosquitoes require essential nutrients for egg production, which they obtain through the acquisition and digestion of a protein-rich blood meal. Therefore, mosquito mass production in laboratories and other facilities relies on vertebrate blood from live animal hosts. However, vertebrate blood is expensive to acquire and hard to store for longer times especially under field conditions. This review discusses older and recent studies that were aimed at the development of artificial diets for mosquitoes in order to replace vertebrate blood.

  15. University of Rochester, Laboratory for Laser Energetics

    Science.gov (United States)

    1987-01-01

    In FY86 the Laboratory has produced a list of accomplishments in which it takes pride. LLE has met every laser-fusion program milestone to date in a program of research for direct-drive ultraviolet laser fusion originally formulated in 1981. LLE scientists authored or co-authored 135 scientific papers during 1985 to 1986. The collaborative experiments with NRL, LANL, and LLNL have led to a number of important ICF results. The cryogenic target system developed by KMS Fusion for LLE will be used in future high-density experiments on OMEGA to demonstrate the compression of thermonuclear fuel to 100 to 200 times that of solid (20 to 40 g/cm) in a test of the direct-drive concept, as noted in the National Academy of Sciences' report. The excellence of the advanced technology efforts at LLE is illustrated by the establishment of the Ultrafast Science Center by the Department of Defense through the Air Force Office of Scientific Research. Research in the Center will concentrate on bridging the gap between high-speed electronics and ultrafast optics by providing education, research, and development in areas critical to future communications and high-speed computer systems. The Laboratory for Laser Energetics continues its pioneering work on the interaction of intense radiation with matter. This includes inertial-fusion and advanced optical and optical electronics research; training people in the technology and applications of high-power, short-pulse lasers; and interacting with the scientific community, business, industry, and government to promote the growth of laser technology.

  16. Cavitation Bubble Nucleation by Energetic Particles

    Energy Technology Data Exchange (ETDEWEB)

    West, C.D.

    1998-12-01

    In the early sixties, experimental measurements using a bubble chamber confirmed quantitatively the thermal spike theory of bubble nucleation by energetic particles: the energy of the slow, heavy alpha decay recoils used in those experiments matched the calculated bubble nucleation energy to within a few percent. It was a triumph, but was soon to be followed by a puzzle. Within a couple of years, experiments on similar liquids, but well below their normal boiling points, placed under tensile stress showed that the calculated bubble nucleation energy was an order of magnitude less than the recoil energy. Why should the theory work so well in the one case and so badly in the other? How did the liquid, or the recoil particle, "know" the difference between the two experiments? Another mathematical model of the same physical process, introduced in 1967, showed qualitatively why different analyses would be needed for liquids with high and low vapor pressures under positive or negative pressures. But, the quantitative agreement between the calculated nucleation energy and the recoil energy was still poor--the former being smaller by a factor of two to three. In this report, the 1967 analysis is extended and refined: the qualitative understanding of the difference between positive and negative pressure nucleation, "boiling" and "cavitation" respectively, is retained, and agreement between the negative pressure calculated to be needed for nucleation and the energy calculated to be available is much improved. A plot of the calculated negative pressure needed to induce bubble formation against the measured value now has a slope of 1.0, although there is still considerable scatter in the individual points.

  17. Cassava For Space Diet

    Science.gov (United States)

    Katayama, Naomi; Yamashita, Masamichi; Njemanze, Philip; Nweke, Felix; Mitsuhashi, Jun; Hachiya, Natumi; Miyashita, Sachiko; Hotta, Atuko

    Space agriculture is an advanced life support enginnering concept based on biological and ecological system ot drive the materials recycle loop and create pleasant life environment on distant planetary bodies. Choice of space diet is one of primary decision required ot be made at designing space agriculture. We propose cassava, Manihot esculenta and, for one major composition of space food materials, and evaluate its value and feasibility of farming and processing it for space diet. Criteria to select space crop species could be stated as follows. 1) Fill th enutritional requirements. There is no perfect food material to meet this requirements without making a combination with others. A set of food materials which are adopted inthe space recipe shall fit to the nutritional requirement. 2) Space food is not just for maintaining physiological activities of human, but an element of human culture. We shall consider joy of dining in space life. In this context, space foos or recipe should be accepted by future astronauts. Food culture is diverse in the world, and has close relatioship to each cultural background. Cassava root tuber is a material to supply mainly energy in the form of carbohydrate, same as cereals and other tuber crops. Cassava leaf is rich in protein high as 5.1 percents about ten times higher content than its tuber. In the food culture in Africa, cassava is a major component. Cassava root tuber in most of its strain contains cyanide, it should be removed during preparation for cooking. However certain strain are less in this cyanogenic compound, and genetically modified cassava can also aboid this problem safely.

  18. MESSENGER observations of energetic electron acceleration in Mercury's magnetotail

    Science.gov (United States)

    Dewey, Ryan; Slavin, James A.; Baker, Daniel; Raines, Jim; Lawrence, David

    2016-10-01

    Energetic particle bursts within Mercury's magnetosphere have been a source of curiosity and controversy since Mariner 10's flybys. Unfortunately, instrumental effects prevent an unambiguous determination of species, flux, and energy spectrum for the Mariner 10 events. MESSENGER data taken by the Energetic Particle Spectrometer (EPS) have now shown that these energetic particle bursts are composed entirely of electrons. EPS made directional measurements of these electrons from ~30 to 300 keV at 3 s resolution, and while the energy of these electrons sometimes exceeded 200 keV, the energy distributions usually exhibited a cutoff near 100 keV. The Gamma Ray Spectrometer (GRS) has also provided measurements of these electron events, at higher time resolution (10 ms) and energetic threshold (> 50 keV) compared to EPS. We focus on GRS electron events near the plasma sheet in Mercury's magnetotail to identify reconnection-associated acceleration mechanisms. We present observations of acceleration associated with dipolarization events (betratron acceleration), flux ropes (Fermi acceleration), and tail loading/unloading (X-line acceleration). We find that the most common source of energetic electron events in Mercury's magnetosphere are dipolarization events similar to those first observed by Mariner 10. Further, a significant dawn-dusk asymmetry is found with dipolarization-associated energetic particle bursts being more common on the dawn side of the magnetotail.

  19. Health effects of vegan diets.

    Science.gov (United States)

    Craig, Winston J

    2009-05-01

    Recently, vegetarian diets have experienced an increase in popularity. A vegetarian diet is associated with many health benefits because of its higher content of fiber, folic acid, vitamins C and E, potassium, magnesium, and many phytochemicals and a fat content that is more unsaturated. Compared with other vegetarian diets, vegan diets tend to contain less saturated fat and cholesterol and more dietary fiber. Vegans tend to be thinner, have lower serum cholesterol, and lower blood pressure, reducing their risk of heart disease. However, eliminating all animal products from the diet increases the risk of certain nutritional deficiencies. Micronutrients of special concern for the vegan include vitamins B-12 and D, calcium, and long-chain n-3 (omega-3) fatty acids. Unless vegans regularly consume foods that are fortified with these nutrients, appropriate supplements should be consumed. In some cases, iron and zinc status of vegans may also be of concern because of the limited bioavailability of these minerals.

  20. Ketogenic diet for epilepsy treatment

    Directory of Open Access Journals (Sweden)

    Letícia Pereira de Brito Sampaio

    Full Text Available ABSTRACT The ketogenic diet (KD, a high-fat, low-carbohydrate, and adequate-protein diet is an established, effective nonpharmacologic treatment option for intractable childhood epilepsy. The KD was developed in 1921 and even though it has been increasingly used worldwide in the past decade, many neurologists are not familiar with this therapeutic approach. In the past few years, alternative and more flexible KD variants have been developed to make the treatment easier and more palatable while reducing side effects and making it available to larger group of refractory epilepsy patients. This review summarizes the history of the KD and the principles and efficacy of the classic ketogenic diet, medium-chain triglyceride(s (MCT ketogenic diet, modified Atkins diet, and low glycemic index treatment.

  1. Diet effects on honeybee immunocompetence.

    Science.gov (United States)

    Alaux, Cédric; Ducloz, François; Crauser, Didier; Le Conte, Yves

    2010-08-23

    The maintenance of the immune system can be costly, and a lack of dietary protein can increase the susceptibility of organisms to disease. However, few studies have investigated the relationship between protein nutrition and immunity in insects. Here, we tested in honeybees (Apis mellifera) whether dietary protein quantity (monofloral pollen) and diet diversity (polyfloral pollen) can shape baseline immunocompetence (IC) by measuring parameters of individual immunity (haemocyte concentration, fat body content and phenoloxidase activity) and glucose oxidase (GOX) activity, which enables bees to sterilize colony and brood food, as a parameter of social immunity. Protein feeding modified both individual and social IC but increases in dietary protein quantity did not enhance IC. However, diet diversity increased IC levels. In particular, polyfloral diets induced higher GOX activity compared with monofloral diets, including protein-richer diets. These results suggest a link between protein nutrition and immunity in honeybees and underscore the critical role of resource availability on pollinator health.

  2. Atkins Diet: What's Behind the Claims?

    Science.gov (United States)

    ... or metabolic syndrome. Why you might follow the Atkins Diet You might choose to follow the Atkins ... for achieving other health benefits. Phases of the Atkins Diet The Atkins Diet has four phases. Depending ...

  3. Your diet after gastric bypass surgery

    Science.gov (United States)

    Gastric bypass surgery - your diet; Obesity - diet after bypass; Weight loss - diet after bypass ... You had gastric bypass surgery. This surgery made your stomach smaller by closing off most of your stomach with staples. It changed the way your ...

  4. Hierarchical Cellular Structures in High-Capacity Cellular Communication Systems

    CERN Document Server

    Jain, R K; Agrawal, N K

    2011-01-01

    In the prevailing cellular environment, it is important to provide the resources for the fluctuating traffic demand exactly in the place and at the time where and when they are needed. In this paper, we explored the ability of hierarchical cellular structures with inter layer reuse to increase the capacity of mobile communication network by applying total frequency hopping (T-FH) and adaptive frequency allocation (AFA) as a strategy to reuse the macro and micro cell resources without frequency planning in indoor pico cells [11]. The practical aspects for designing macro- micro cellular overlays in the existing big urban areas are also explained [4]. Femto cells are inducted in macro / micro / pico cells hierarchical structure to achieve the required QoS cost effectively.

  5. Energetic Materials Effects on Essential Soil Processes: Decomposition of Orchard Grass (Dactylis glomerata) Litter in Soil Contaminated with Energetic Materials

    Science.gov (United States)

    2014-02-01

    GRASS (DACTYLIS GLOMERATA) LITTER IN SOIL CONTAMINATED WITH ENERGETIC MATERIALS ECBC-TR-1199 Roman G. Kuperman Ronald T. Checkai Michael Simini...of Orchard Grass (Dactylis glomerata) Litter in Soil Contaminated with Energetic Materials 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...soils using the U.S. Environmental Protection Agency Method 8330A. The results showed that soil contamination with 2,4-DNT or NG can inhibit litter

  6. Diet and fertility in cattle

    Directory of Open Access Journals (Sweden)

    Petrujkić Tihomir

    2003-01-01

    Full Text Available The diet of high-yield dairy cows process a very complex and acute problem. Much new knowledge in the area of production and preparation of feedstuffs, diet technology, and the interactions that occur between the components of the nutritive feed ration are required in order to resolve this problem. It is necessary constantly to coordinate feed norms with genetic potential which is ever changing and advanced. The observed problems must be resolved using multidisciplinary methods so that a diet can yield good health, and that health contribute to better reproduction and possibilities for more successful breeding and improved performance in cattle farming. In certain countries, thanks to their geographic position and climatic conditions which allow rainfall throughout the year, a natural green diet can be applied, which provides large numbers of green mass components, and with additives which can be supplemented relatively easily. This type of diet is not possible in our farms. It is very important to know which feedstuff components are laking for certain categories of cattle. The used ration must be constant and administered to animals of certain age or production characteristics in order to improve production results at cattle farms. A great problem occurs when diet is reduced due to dried grass and the resulting stress in animals. A 50% diet reduction in young cattle often results in the occurrence of respiratory diseases. Following 10-14 days of treatment, the disease disappears in young animals, but the energy deficit leads to the weakening (depression of the immune system. Even a so-called high-energy diet often causes respiratory diseases. A diet deficient in proteins also affects cows after lactation, as opposed to a normative diet, and a reduced protein diet disturbs the microbial activity in the rumen and the synthesis of compounds which are important for both the cow and the calf, making room for the incidence of metabolic diseases, most

  7. Classifying cellular automata using grossone

    Science.gov (United States)

    D'Alotto, Louis

    2016-10-01

    This paper proposes an application of the Infinite Unit Axiom and grossone, introduced by Yaroslav Sergeyev (see [7] - [12]), to the development and classification of one and two-dimensional cellular automata. By the application of grossone, new and more precise nonarchimedean metrics on the space of definition for one and two-dimensional cellular automata are established. These new metrics allow us to do computations with infinitesimals. Hence configurations in the domain space of cellular automata can be infinitesimally close (but not equal). That is, they can agree at infinitely many places. Using the new metrics, open disks are defined and the number of points in each disk computed. The forward dynamics of a cellular automaton map are also studied by defined sets. It is also shown that using the Infinite Unit Axiom, the number of configurations that follow a given configuration, under the forward iterations of cellular automaton maps, can now be computed and hence a classification scheme developed based on this computation.

  8. Prognosis of Different Cellular Generations

    Directory of Open Access Journals (Sweden)

    Preetish Ranjan

    2013-04-01

    Full Text Available Technological advancement in mobile telephony from 1G to 3G, 4G and 5G has a very axiomatic fact that made an entire world a global village. The cellular system employs a different design approach and technology that most commercial radio and television system use. In the cellular system, the service area is divided into cells and a transmitter is designed to serve an individual cell. The system seeks to make efficient use of available channels by using low-power transmitters to allow frequency reuse at a smaller distance. Maximizing the number of times each channel can be reused in a given geographical area is the key to an efficient cellular system design. During the past three decades, the world has seen significant changes in telecommunications industry. There have been some remarkable aspects to the rapid growth in wireless communications, as seen by the large expansion in mobile systems. This paper focuses on “Past, Present & Future of Cellular Telephony” and some light has been thrown upon the technologies of the cellular systems, namely 1G, 2G, 2.5G, 3G and future generations like 4G and 5G systems as well.

  9. Microbial Energetics Beneath the Taylor Glacier, Antarctica

    Science.gov (United States)

    Mikucki, J. A.; Turchyn, A. V.; Farquhar, J.; Priscu, J. C.; Schrag, D. P.; Pearson, A.

    2007-12-01

    Subglacial microbiology is controlled by glacier hydrology, bedrock lithology, and the preglacial ecosystem. These factors can all affect metabolic function by influencing electron acceptor and donor availability in the subglacial setting leaving biogeochemical signatures that can be used to determine ecosystem processes. Blood Falls, an iron-rich, episodic subglacial outflow from the Taylor Glacier in the McMurdo Dry Valleys Antarctica provides an example of how microbial community structure and function can provide insight into subglacial hydrology. This subglacial outflow contains cryoconcentrated, Pliocene-age seawater salts that pooled in the upper Taylor Valley and was subsequently covered by the advance of the Taylor Glacier. Biogeochemical measurements, culture-based techniques, and genomic analysis were used to characterize microbes and chemistry associated with the subglacial outflow. The isotopic composition of important geochemical substrates (i.e., δ34Ssulfate, Δ33Ssulfate, δ18Osulfate, δ18Owater, Δ14SDIC) were also measured to provide more detail on subglacial microbial energetics. Typically, subglacial systems, when driven to anoxia by the hydrolysis of organic matter, will follow a continuum of redox chemistries utilizing electron acceptors with decreasing reduction potential (e.g., Fe (III), sulfate, CO2). Our data provide no evidence for sulfate reduction below the Taylor Glacier despite high dissolved organic carbon (450 μM C) and measurable metabolic activity. We contend that, in the case of the Taylor Glacier, the in situ bioenergetic reduction potential has been 'short-circuited' at Fe(III)-reduction and excludes sulfate reduction and methanogenesis. Given the length of time that this marine system has been isolated from phototrophic production (~2 Mya) the ability to degrade and consume increasingly recalcitrant organic carbon is likely an important component to the observed redox chemistry. Our work indicates that glacier hydrology

  10. Salt-bridge energetics in halophilic proteins.

    Directory of Open Access Journals (Sweden)

    Arnab Nayek

    Full Text Available Halophilic proteins have greater abundance of acidic over basic and very low bulky hydrophobic residues. Classical electrostatic stabilization was suggested as the key determinant for halophilic adaptation of protein. However, contribution of specific electrostatic interactions (i.e. salt-bridges to overall stability of halophilic proteins is yet to be understood. To understand this, we use Adaptive-Poison-Boltzmann-Solver Methods along with our home-built automation to workout net as well as associated component energy terms such as desolvation energy, bridge energy and background energy for 275 salt-bridges from 20 extremely halophilic proteins. We then perform extensive statistical analysis on general and energetic attributes on these salt-bridges. On average, 8 salt-bridges per 150 residues protein were observed which is almost twice than earlier report. Overall contributions of salt-bridges are -3.0 kcal mol-1. Majority (78% of salt-bridges in our dataset are stable and conserved in nature. Although, average contributions of component energy terms are equal, their individual details vary greatly from one another indicating their sensitivity to local micro-environment. Notably, 35% of salt-bridges in our database are buried and stable. Greater desolvation penalty of these buried salt-bridges are counteracted by stable network salt-bridges apart from favorable equal contributions of bridge and background terms. Recruitment of extensive network salt-bridges (46% with a net contribution of -5.0 kcal mol-1 per salt-bridge, seems to be a halophilic design wherein favorable average contribution of background term (-10 kcal mol-1 exceeds than that of bridge term (-7 kcal mol-1. Interiors of proteins from halophiles are seen to possess relatively higher abundance of charge and polar side chains than that of mesophiles which seems to be satisfied by cooperative network salt-bridges. Overall, our theoretical analyses provide insight into halophilic

  11. Novel Materials for Cellular Nanosensors

    DEFF Research Database (Denmark)

    Sasso, Luigi

    The monitoring of cellular behavior is useful for the advancement of biomedical diagnostics, drug development and the understanding of a cell as the main unit of the human body. Micro- and nanotechnology allow for the creation of functional devices that enhance the study of cellular dynamics...... modifications for electrochemical nanosensors for the detection of analytes released from cells. Two type of materials were investigated, each pertaining to the two different aspects of such devices: peptide nanostructures were studied for the creation of cellular sensing substrates that mimic in vivo surfaces...... and that offer advantages of functionalization, and conducting polymers were used as electrochemical sensor surface modifications for increasing the sensitivity towards relevant analytes, with focus on the detection of dopamine released from cells via exocytosis. Vertical peptide nanowires were synthesized from...

  12. [The mechanism of phenoptosis: I. Age-dependent decrease of the overall rate of protein synthesis is caused by the programmed attenuation of bio-energetics].

    Science.gov (United States)

    Trubitsyn, A G

    2009-01-01

    The age-dependent degradation of all vital processes of an organism can be result of influences of destructive factors (the stochastic mechanism of aging), or effect of realizations of the genetic program (phenoptosis). The stochastic free-radical theory of aging dominating now contradicts the set of empirical data, and the semicentenial attempts to create the means to slow down aging did not give any practical results. It makes obvious that the stochastic mechanism of aging is incorrect. At the same time, the alternative mechanism of the programmed aging is not developed yet but preconditions for it development have already been created. It is shown that the genes controlling process of aging exist (contrary to the customary opinion) and the increase in the level of damaged macromolecules (basic postulate of the free-radical theory) can be explained by programmed attenuation of bio-energetics. As the bio-energetics is a driving force of all vital processes, decrease of its level is capable to cause degradation of all functions of an organism. However to transform this postulate into a basis of the theory of phenoptosis it is necessary to show, that attenuation of bio-energetics predetermines such fundamental processes accompanying aging as decrease of the overall rate of protein biosynthesis, restriction of cellular proliferations (Hayflick limit), loss of telomeres etc. This article is the first step in this direction: the natural mechanism of interaction of overall rate of protein synthesis with a level of cellular bio-energetics is shown. This is built-in into the translation machine and based on dependence of recirculation rate of eukaryotic initiation factor 2 (elF2) from ATP/ADP value that is created by mitochondrial bio-energetic machine.

  13. Cognitive health and Mediterranean diet: just diet or lifestyle pattern?

    Science.gov (United States)

    Yannakoulia, Mary; Kontogianni, Meropi; Scarmeas, Nikolaos

    2015-03-01

    Mediterranean diet is a term used to describe the traditional eating habits of people in Crete, South Italy and other Mediterranean countries. It is a predominantly plant-based diet, with olive oil being the main type of added fat. There are many observational studies exploring the potential association between adherence to the Mediterranean diet and cognitive decline. The present review focuses on longitudinal studies with repeated cognitive assessments. It also evaluates evidence on behaviors related to the Mediterranean way of living, that have been shown to be associated with cognition, namely social interaction, participation in leisure activities, including physical activities, and sleep quality. The synergistic association-effect of these lifestyle behaviors, including diet, is unknown. Lifestyle patterns may constitute a new research and public health perspective.

  14. Cellular models for Parkinson's disease.

    Science.gov (United States)

    Falkenburger, Björn H; Saridaki, Theodora; Dinter, Elisabeth

    2016-10-01

    Developing new therapeutic strategies for Parkinson's disease requires cellular models. Current models reproduce the two most salient changes found in the brains of patients with Parkinson's disease: The degeneration of dopaminergic neurons and the existence of protein aggregates consisting mainly of α-synuclein. Cultured cells offer many advantages over studying Parkinson's disease directly in patients or in animal models. At the same time, the choice of a specific cellular model entails the requirement to focus on one aspect of the disease while ignoring others. This article is intended for researchers planning to use cellular models for their studies. It describes for commonly used cell types the aspects of Parkinson's disease they model along with technical advantages and disadvantages. It might also be helpful for researchers from other fields consulting literature on cellular models of Parkinson's disease. Important models for the study of dopaminergic neuron degeneration include Lund human mesencephalic cells and primary neurons, and a case is made for the use of non-dopaminergic cells to model pathogenesis of non-motor symptoms of Parkinson's disease. With regard to α-synuclein aggregates, this article describes strategies to induce and measure aggregates with a focus on fluorescent techniques. Cellular models reproduce the two most salient changes of Parkinson's disease, the degeneration of dopaminergic neurons and the existence of α-synuclein aggregates. This article is intended for researchers planning to use cellular models for their studies. It describes for commonly used cell types and treatments the aspects of Parkinson's disease they model along with technical advantages and disadvantages. Furthermore, this article describes strategies to induce and measure aggregates with a focus on fluorescent techniques. This article is part of a special issue on Parkinson disease.

  15. Synthesis of Energetic Nitrocarbamates from Polynitro Alcohols and Their Potential as High Energetic Oxidizers.

    Science.gov (United States)

    Axthammer, Quirin J; Krumm, Burkhard; Klapötke, Thomas M

    2015-06-19

    A new synthesis strategy for the preparation of energetic carbamates and nitrocarbamates starting from readily available polynitro alcohols is introduced. The efficient synthesis of mainly new carbamates was performed with the reactive chlorosulfonyl isocyanate (CSI) reagent. The carbamates were nitrated using mixed acid to form the corresponding primary nitrocarbamates. The thermal stability of all synthesized compounds was studied using differential scanning calorimetry, and the energies of formation were calculated on the CBS-4 M level of theory. Detonation parameters and propulsion properties were determined with the software package EXPLO5 V6.02. Furthermore, for all new substances single-crystal X-ray diffraction studies were performed and are presented and discussed as Supporting Information.

  16. Cellular basis of Alzheimer's disease.

    Science.gov (United States)

    Bali, Jitin; Halima, Saoussen Ben; Felmy, Boas; Goodger, Zoe; Zurbriggen, Sebastian; Rajendran, Lawrence

    2010-12-01

    Alzheimer's disease (AD) is the most common form of neurodegenerative disease. A characteristic feature of the disease is the presence of amyloid-β (Aβ) which either in its soluble oligomeric form or in the plaque-associated form is causally linked to neurodegeneration. Aβ peptide is liberated from the membrane-spanning -amyloid precursor protein by sequential proteolytic processing employing β- and γ-secretases. All these proteins involved in the production of Aβ peptide are membrane associated and hence, membrane trafficking and cellular compartmentalization play important roles. In this review, we summarize the key cellular events that lead to the progression of AD.

  17. Diet and gastric cancer

    Directory of Open Access Journals (Sweden)

    Šipetić Sandra B.

    2003-01-01

    Full Text Available The aim of this case-control study, conducted in Serbia during the period 1998-2000, was to investigate whether diet was associated with the development of gastric cancer. The case group consisted of 131 patients with histologically confirmed gastric cancer, and the control group of 131 patients with orthopedics diseases and injuries. Cases and controls were individually matched by age (±± 2 years, gender, and place of residence. On the basis of multivariate logistic regression analysis, following factors were found as independent risk factors for gastric cancer: more frequent consumption of high-fat milk [Odds ratio (OR =1.45, 95% confidence interval (CI = 0.99-2.16]; mutton, lamb and/or calf meat (OR = 2.46, 95% CI = 1.11-5.47, sugar (OR = 2.13, 95% CI = 1.43-3.18, semi-white bread (OR = 2.09, 95% CI = 1.25-3.50, and salting food (OR = 5.72, 95% CI = 2.63-12.42. Factors found as protective were: more frequent consumption of margarine (OR = 0.41, 95% CI = 0.25-0.69, „other“ cheeses (OR = 0.47, 95% CI = 0.29 - 0.77, and fish (OR = 0.39, 95% CI = 0.19-0.76.

  18. Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers

    Science.gov (United States)

    Monteiro, Maria Emília L; Xavier, Analucia R; Oliveira, Felipe L; Filho, Porphirio JS; Azeredo, Vilma B

    2016-01-01

    AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat livers. METHODS: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93M diet, and animals in the experimental group received an Atkins-based diet (59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies. We expressed the data as mean ± standard deviation (SD) assuming unpaired and parametric data; we analyzed differences using the Student’s t-test. Statistical significance was set at P diet group and 3.73% ± 0.50% for early apoptosis, 5.67% ± 0.72% for late apoptosis, and 3.82% ± 0.28% for non-apoptotic death in the control diet group. The mean percentage of early apoptosis was higher in the experimental diet group than in the control diet group. Immunohistochemistry for autophagy was negative in both groups. Sinusoidal dilation around the central vein and small hepatocytes was only observed in the experimental diet group, and fibrosis was not identified by hematoxylin-eosin or Trichrome Masson staining in either group. CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. PMID:27298559

  19. Effects of antibacterial peptide on cellular immunity in weaned piglets.

    Science.gov (United States)

    Ren, Z H; Yuan, W; Deng, H D; Deng, J L; Dan, Q X; Jin, H T; Tian, C L; Peng, X; Liang, Z; Gao, S; Xu, S H; Li, G; Hu, Y

    2015-01-01

    The aim of this study was to evaluate the effects of antibacterial peptide (ABP) sufficiency on cellular immune functions by determining the spleen cell cycle and apoptosis, peripheral blood T cell subsets, and T cell proliferation function in weaned piglets. A total of 90 piglets (Duroc × Landrace × Yorkshire) of both sexes were randomly allotted to 5 dietary treatments. Each treatment consisted of 3 replicates with 6 piglets per replicate. The dietary treatments consisted of the negative control (NC; basal diet), positive control (PC; basal diet supplemented with 400 mg/kg Astragalus polysaccharide), and ABP (basal diet mixed with 250, 500, and 1,000 mg/kg ABP). The experimental lasted for 28 d. Two piglets from each replicate were selected randomly for blood samples extraction from the jugular vein to obtain peripheral blood T cell subsets, and T cell proliferation function analysis was performed on d 32, 39, 46, and 53. Two piglets from each replicate were selected and euthanized to observe the spleen cell cycle and apoptosis on d 39 and 53. In ABP-sufficient piglets, the G0/G1 phase of the spleen cell cycle was much lower (P ABP sufficiency (P ABP-sufficient piglets. Percentages of CD3 (+) and CD3 (+)CD4 (+) ratios (d 39, 46, and 53) and CD4 (+)CD8 (+) ratios (d 32, 39, 46, and 53) increased remarkably (P ABP sufficiency compared with NC. These results suggest that ABP sufficiency could increase the T cell population and proliferation function of T cells and could induce decreased percentages of apoptotic cells. Overall, the cellular immune function was evidently improved in weaned piglets. We suggest optimal dosages of 500 mg/kg ABP for 4-wk addition and 1,000 mg/kg ABP for 2-wk addition.

  20. Evaluation of Energetic Plasticisers for Solid Gun Propellant

    Directory of Open Access Journals (Sweden)

    R.S. Damse

    2008-01-01

    Full Text Available This paper reports the evaluation of four different energetic plasticisers, viz., glycidyl azidepolymer (GAP, MW = 390, 1,5-diazido-3-nitrazapentane (DANPE, ethylene-glycol-bis-azido-acetate (EGBAA and N-n-butyl-N-(2 nitroxyethyl nitramine (n-Bu-NENA separately into highenergy gun propellant containing 28 per cent NC (13.1 N %, 65 per cent RDX, 6 per cent di-octyl-phthahate (DOP and 1 per cent carbamite.  Four different propellant compositions based on theenergetic plasticiser have been formulated separately with the replacement of non-energeticplasticiser, DOP. The propellants were processed by standard solvent method and evaluatedexperimentally along with the control composition to determine the ballistic parameters, cal-val,sensitivity, thermal characterisation, thermal stability and mechanical properties. The performanceof the propellants containing the energetic plasticiser has  been compared with that of thecontrol composition containing the non-energetic plasticiser, DOP so as to assess the suitabilityof the energetic plasticiser for the futuristic gun propellant formulations. It has been found outthat n-Bu-NENA is the superior plasticiser among the four energetic plasticisers evaluated inthis study.Defence Science Journal, 2008, 58(1, pp.86-93, DOI:http://dx.doi.org/10.14429/dsj.58.1627

  1. Highly energetic compositions based on functionalized carbon nanomaterials

    Science.gov (United States)

    Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi; Cohen, Adva; Pang, Si-Ping

    2016-02-01

    In recent years, research in the field of carbon nanomaterials (CNMs), such as fullerenes, expanded graphite (EG), carbon nanotubes (CNTs), graphene, and graphene oxide (GO), has been widely used in energy storage, electronics, catalysts, and biomaterials, as well as medical applications. Regarding energy storage, one of the most important research directions is the development of CNMs as carriers of energetic components by coating or encapsulation, thus forming safer advanced nanostructures with better performances. Moreover, some CNMs can also be functionalized to become energetic additives. This review article covers updated preparation methods for the aforementioned CNMs, with a more specific orientation towards the use of these nanomaterials in energetic compositions. The effects of these functionalized CNMs on thermal decomposition, ignition, combustion and the reactivity properties of energetic compositions are significant and are discussed in detail. It has been shown that the use of functionalized CNMs in energetic compositions greatly improves their combustion performances, thermal stability and sensitivity. In particular, functionalized fullerenes, CNTs and GO are the most appropriate candidate components in nanothermites, solid propellants and gas generators, due to their superior catalytic properties as well as facile preparation methods.

  2. Diabetes Diet, Eating, & Physical Activity

    Science.gov (United States)

    ... Disease, & Other Dental Problems Diabetes & Sexual & Urologic Problems Diabetes Diet, Eating, & Physical Activity Nutrition and physical activity ... What foods can I eat if I have diabetes? You may worry that having diabetes means going ...

  3. GoM Diet Matrix

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set was taken from CRD 08-18 at the NEFSC. Specifically, the Gulf of Maine diet matrix was developed for the EMAX exercise described in that center...

  4. Eating practices and diet quality

    DEFF Research Database (Denmark)

    Holm, Lotte; Lund, Thomas Bøker; Niva, Mari

    2015-01-01

    Background/objectives: Daily practices related to eating are embedded in the social and cultural contexts of everyday life. How are such factors associated with diet quality relative to motivational factors? And, are associations universal or context-specific? We analyze the relationship between...... diet quality and the following practices: social company while eating, the regularity and duration of eating and the activity of watching TV while eating. Subjects/methods: A cross-sectional, questionnaire-based internet survey was conducted in April 2012 with stratified random samples...... is based on eight food frequency questions focusing on fats, vegetables, fruits and fish in the diet. Results: Eating activities were associated with diet quality even when motivation to eat healthily and sociodemographic factors were controlled for. The number of daily eating events and eating main meals...

  5. Hepatitis C: Diet and Nutrition

    Science.gov (United States)

    ... infected, but a good diet can help reduce body fat and control blood sugar. This lowers diabetes risk. ... body weight (measured as Body Mass Index , or BMI) may not seem like a specific treatment for ...

  6. Diet and Nutrition With Lupus

    Science.gov (United States)

    ... Facebook Pinterest Email Print Diet and nutrition with lupus Lupus Foundation of America March 16, 2017 Resource ... processed foods should be avoided. Should people with lupus stop eating red meat? There’s no scientific evidence ...

  7. Cystic Fibrosis: Diet and Nutrition

    Science.gov (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Cystic Fibrosis: Diet and Nutrition KidsHealth > For Teens > Cystic Fibrosis: ... Food Enzyme Supplements Beating the Frustration What Is Cystic Fibrosis? At lunch, Lindsay often gets bored with having ...

  8. Traveler’s diarrhea diet

    Science.gov (United States)

    ... risk for getting traveler's diarrhea by avoiding water, ice, and food that may be contaminated. The goal of the traveler's diarrhea diet is to make your symptoms better and prevent you from getting ...

  9. Diet History Questionnaire: International Applications

    Science.gov (United States)

    ARP staff adapted the Diet History Questionnaire (DHQ) for use by Canadian populations in collaboration with the Alberta Cancer Board. This questionnaire takes into account the different food fortification polices of the U.S. and Canada.

  10. Diet Choices to Prevent Cancer

    Science.gov (United States)

    ... Situations Pets and Animals myhealthfinder Food and Nutrition Healthy Food Choices Weight Loss and Diet Plans Nutrients and Nutritional Info Sugar and Sugar Substitutes Exercise and Fitness Exercise Basics Sports Safety Injury Rehabilitation Emotional Well- ...

  11. Search for the optimal diet.

    Science.gov (United States)

    Mullin, Gerard E

    2010-12-01

    Since the beginning of time, we have been searching for diets that satisfy our palates while simultaneously optimizing health and well-being. Every year, there are hundreds of new diet books on the market that make a wide range of promises but rarely deliver. Unfortunately, consumers are gullible and believe much of the marketing hype because they are desperately seeking ways to maximize their health. As a result, they continue to purchase these diet books, sending many of them all the way to the bestseller list. Because many of these meal plans are not sustainable and are questionable in their approaches, the consumer is ultimately left to continue searching, only able to choose from the newest "fad" promoted by publicists rather than being grounded in science. Thus, the search for the optimal diet continues to be the "holy grail" for many of us today, presenting a challenge for nutritionists and practitioners to provide sound advice to consumers.

  12. Study of energetic-particle-irradiation induced biological effect on Rhizopus oryzae through synchrotron-FTIR micro-spectroscopy

    Science.gov (United States)

    Liu, Jinghua; Qi, Zeming; Huang, Qing; Wei, Xiaoli; Ke, Zhigang; Fang, Yusheng; Tian, Yangchao; Yu, Zengliang

    2013-01-01

    Energetic particles exist ubiquitously and cause varied biological effects such as DNA strand breaks, lipid peroxidation, protein modification, cell apoptosis or death. An emerging biotechnology based on ion-beam technique has been developed to serve as an effective tool for mutation breeding of crops and microbes. In order to improve the effectiveness of ion-beam biotechnology for mutation breeding, it is indispensible to gain a better understanding of the mechanism of the interactions between the energetic ions and biological systems which is still elusive. A new trend is to conduct more comprehensive research which is based on micro-scaled observation of the changes of the cellular structures and compositions under the interactions. For this purpose, advanced synchrotron FTIR (s-FTIR) microscopy was employed to monitor the cellular changes of single fungal hyphae under irradiation of α-particles from 241Am. Intracellular contents of ROS, MDA, GSSG/GSH and activities of CAT and SOD were measured via biochemical assay. Ion-irradiation on Rhizopus oryzae causes localized vacuolation, autolysis of cell wall and membrane, lipid peroxidation, DNA damage and conformational changes of proteins, which have been clearly revealed by the s-FTIR microspectroscopy. The different changes of cell viability, SOD and CAT activities can be explained by the ROS-involved chemical reactions. Evidently, the elevated level of ROS in hyphal cells upon irradiation plays the key role in the caused biological effect. This study demonstrates that s-FTIR microspectroscopy is an effective tool to study the damage of fungal hyphae caused by ionizing radiation and it facilitates the exploit of the mechanism for the interactions between the energetic ions and biological systems.

  13. Brief Communication: Seasonality of diet composition is related to brain size in New World Monkeys.

    Science.gov (United States)

    van Woerden, Janneke T; van Schaik, Carel P; Isler, Karin

    2014-08-01

    New World monkeys exhibit a more pronounced variability in encephalization than other primate taxa. In this comparative study, we tested two current hypotheses on brain size evolution, the Expensive Brain hypothesis and the Cognitive Buffer hypothesis, in a sample of 21 platyrrhine species. A high degree of habitat seasonality may impose an energetic constraint on brain size evolution if it leads to a high variation in caloric intake over time, as predicted by the Expensive Brain Hypothesis. However, simultaneously it may also provide the opportunity to reap the fitness benefits of increased cognitive abilities, which enable the exploitation of high-quality food resources even during periods of scarcity, as predicted by the Cognitive Buffer hypothesis. By examining the effects of both habitat seasonality and the variation in monthly diet composition across species, we found support for both hypotheses, confirming previous results for catarrhine primates and lemurs. These findings are in accordance with an energetic and ecological view of brain size evolution.

  14. On Cellular MIMO Channel Capacity

    Science.gov (United States)

    Adachi, Koichi; Adachi, Fumiyuki; Nakagawa, Masao

    To increase the transmission rate without bandwidth expansion, the multiple-input multiple-output (MIMO) technique has recently been attracting much attention. The MIMO channel capacity in a cellular system is affected by the interference from neighboring co-channel cells. In this paper, we introduce the cellular channel capacity and evaluate its outage capacity, taking into account the frequency-reuse factor, path loss exponent, standard deviation of shadowing loss, and transmission power of a base station (BS). Furthermore, we compare the cellular MIMO downlink channel capacity with those of other multi-antenna transmission techniques such as single-input multiple-output (SIMO) and space-time block coded multiple-input single-output (STBC-MISO). We show that the optimum frequency-reuse factor F that maximizes 10%-outage capacity is 3 and both 50%- and 90%-outage capacities is 1 irrespective of the type of multi-antenna transmission technique, where q%-outage capacity is defined as the channel capacity that gives an outage probability of q%. We also show that the cellular MIMO channel capacity is always higher than those of SIMO and STBC-MISO.

  15. Cellular uptake of metallated cobalamins

    DEFF Research Database (Denmark)

    Tran, MQT; Stürup, Stefan; Lambert, Ian H.;

    2016-01-01

    Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass spectrometry (ICP-MS). Vitamin B12 (cyano-cob(iii)alamin) and aquo-cob(iii)alamin [Cbl-OH2](+), which differ in the β-axial ligands (CN(-...

  16. NANOSTRUCTURE PATTERNING UNDER ENERGETIC PARTICLE BEAM IRRADIATION

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lumin [Regents of the University of Michigan; Lu, Wei [Regents of the University of Michigan

    2013-01-31

    Energetic ion bombardment can lead to the development of complex and diverse nanostructures on or beneath the material surface through induced self-organization processes. These self-organized structures have received particular interest recently as promising candidates as simple, inexpensive, and large area patterns, whose optical, electronic and magnetic properties are different from those in the bulk materials [1-5]. Compared to the low mass efficiency production rate of lithographic methods, these self-organized approaches display new routes for the fabrication of nanostructures over large areas in a short processing time at the nanoscale, beyond the limits of lithography [1,4]. Although it is believed that surface nanostructure formation is based on the morphological instability of the sputtered surface, driven by a kinetic balance between roughening and smoothing actions [6,7], the fundamental mechanisms and experimental conditions for the formation of these nanostructures has still not been well established, the formation of the 3-D naopatterns beneath the irradiated surface especially needs more exploration. During the last funding period, we have focused our efforts on irradiation-induced nanostructures in a broad range of materials. These structures have been studied primarily through in situ electron microscopy during electron or ion irradiation. In particular, we have performed studies on 3-D void/bubble lattices (in metals and CaF2), embedded sponge-like porous structure with uniform nanofibers in irradiated semiconductors (Ge, GaSb, and InSb), 2-D highly ordered pattern of nanodroplets (on the surface of GaAs), hexagonally ordered nanoholes (on the surface of Ge), and 1-D highly ordered ripple and periodic arrays (of Cu nanoparticles) [3,8-11]. The amazing common feature in those nanopatterns is the uniformity of the size of nanoelements (nanoripples, nanodots, nanovoids or nanofibers) and the distance separating them. Our research focuses on the

  17. Redox regulation of SIRT1 in inflammation and cellular senescence.

    Science.gov (United States)

    Hwang, Jae-woong; Yao, Hongwei; Caito, Samuel; Sundar, Isaac K; Rahman, Irfan

    2013-08-01

    Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence, endothelial functions, apoptosis/autophagy, and circadian rhythms through deacetylation of transcription factors and histones. SIRT1 level and activity are decreased in chronic inflammatory conditions and aging, in which oxidative stress occurs. SIRT1 is regulated by a NAD(+)-dependent DNA repair enzyme, poly(ADP-ribose) polymerase-1 (PARP1), and subsequent NAD(+) depletion by oxidative stress may have consequent effects on inflammatory and stress responses as well as cellular senescence. SIRT1 has been shown to undergo covalent oxidative modifications by cigarette smoke-derived oxidants/aldehydes, leading to posttranslational modifications, inactivation, and protein degradation. Furthermore, oxidant/carbonyl stress-mediated reduction of SIRT1 leads to the loss of its control on acetylation of target proteins including p53, RelA/p65, and FOXO3, thereby enhancing the inflammatory, prosenescent, and apoptotic responses, as well as endothelial dysfunction. In this review, the mechanisms of cigarette smoke/oxidant-mediated redox posttranslational modifications of SIRT1 and its roles in PARP1 and NF-κB activation, and FOXO3 and eNOS regulation, as well as chromatin remodeling/histone modifications during inflammaging, are discussed. Furthermore, we have also discussed various novel ways to activate SIRT1 either directly or indirectly, which may have therapeutic potential in attenuating inflammation and premature senescence involved in chronic lung diseases.

  18. Membrane-Based Functions in the Origin of Cellular Life

    Science.gov (United States)

    Chipot, Christophe; New, Michael H.; Schweighofer, Karl; Pohorille, Andrew; Wilson, Michael A.

    1999-01-01

    Our objective is to help explain how the earliest ancestors of contemporary cells (protocells) performed their essential functions employing only the molecules available in the protobiological milieu. Our hypothesis is that vesicles, built of amphiphilic, membrane-forming materials, emerged early in protobiological evolution and served as precursors to protocells. We further assume that the cellular functions associated with contemporary membranes, such as capturing and, transducing of energy, signaling, or sequestering organic molecules and ions, evolved in these membrane environments. An alternative hypothesis is that these functions evolved in different environments and were incorporated into membrane-bound structures at some later stage of evolution. We focus on the application of the fundamental principles of physics and chemistry to determine how they apply to the formation of a primitive, functional cell. Rather than attempting to develop specific models for cellular functions and to identify the origin of the molecules which perform these functions, our goal is to define the structural and energetic conditions that any successful model must fulfill, therefore providing physico-chemical boundaries for these models. We do this by carrying out large-scale, molecular level computer simulations on systems of interest.

  19. The origin of cellular life

    Science.gov (United States)

    Ingber, D. E.

    2000-01-01

    This essay presents a scenario of the origin of life that is based on analysis of biological architecture and mechanical design at the microstructural level. My thesis is that the same architectural and energetic constraints that shape cells today also guided the evolution of the first cells and that the molecular scaffolds that support solid-phase biochemistry in modern cells represent living microfossils of past life forms. This concept emerged from the discovery that cells mechanically stabilize themselves using tensegrity architecture and that these same building rules guide hierarchical self-assembly at all size scales (Sci. Amer 278:48-57;1998). When combined with other fundamental design principles (e.g., energy minimization, topological constraints, structural hierarchies, autocatalytic sets, solid-state biochemistry), tensegrity provides a physical basis to explain how atomic and molecular elements progressively self-assembled to create hierarchical structures with increasingly complex functions, including living cells that can self-reproduce.

  20. The potential of a high protein-low carbohydrate diet to preserve intrahepatic triglyceride content in healthy humans.

    Directory of Open Access Journals (Sweden)

    Eveline A Martens

    Full Text Available BACKGROUND: Protein supplementation has been shown to reduce the increases in intrahepatic triglyceride (IHTG content induced by acute hypercaloric high-fat and high-fructose diets in humans. OBJECTIVE: To assess the effect of a 12-wk iso-energetic high protein-low carbohydrate (HPLC diet compared with an iso-energetic high carbohydrate-low protein (HCLP diet on IHTG content in healthy non-obese subjects, at a constant body weight. DESIGN: Seven men and nine women [mean ± SD age: 24 ± 5 y; BMI: 22.9 ± 2.1 kg/m2] were randomly allocated to a HPLC [30/35/35% of energy (En% from protein/carbohydrate/fat] or a HCLP (5/60/35 En% diet by stratification on sex, age and BMI. Dietary guidelines were prescribed based on individual daily energy requirements. IHTG content was measured by 1H-magnetic resonance spectroscopy before and after the dietary intervention. RESULTS: IHTG content changed in different directions with the HPLC (CH2H2O: 0.23 ± 0.17 to 0.20 ± 0.10; IHTG%: 0.25 ± 0.20% to 0.22 ± 0.11% compared with the HCLP diet (CH2H2O: 0.34 ± 0.20 vs. 0.38 ± 0.21; IHTG%: 0.38 ± 0.22% vs. 0.43 ± 0.24%, which resulted in a lower IHTG content in the HPLC compared with the HCLP diet group after 12 weeks, which almost reached statistical significance (P = 0.055. CONCLUSIONS: A HPLC vs. a HCLP diet has the potential to preserve vs. enlarge IHTG content in healthy non-obese subjects at a constant body weight. TRIAL REGISTRATION: Clinicaltrials.gov NCT01551238.

  1. Energetics of atomic scale structure changes in graphene.

    Science.gov (United States)

    Skowron, Stephen T; Lebedeva, Irina V; Popov, Andrey M; Bichoutskaia, Elena

    2015-05-21

    The presence of defects in graphene has an essential influence on its physical and chemical properties. The formation, behaviour and healing of defects are determined by energetic characteristics of atomic scale structure changes. In this article, we review recent studies devoted to atomic scale reactions during thermally activated and irradiation-induced processes in graphene. The formation energies of vacancies, adatoms and topological defects are discussed. Defect formation, healing and migration are quantified in terms of activation energies (barriers) for thermally activated processes and by threshold energies for processes occurring under electron irradiation. The energetics of defects in the graphene interior and at the edge is analysed. The effects of applied strain and a close proximity of the edge on the energetics of atomic scale reactions are overviewed. Particular attention is given to problems where further studies are required.

  2. The source of multi spectral energy of solar energetic electron

    Energy Technology Data Exchange (ETDEWEB)

    Herdiwijaya, Dhani [Astronomy Division and Bosscha Observatory, Faculty Mathematics and Natural Sciences, Intitute Technology of Bandung, Ganesha 10, Bandung, Indonesia 40132 dhani@as.itb.ac.id (Indonesia)

    2015-04-16

    We study the solar energetic electron distribution obtained from ACE and GOES satellites which have different altitudes and electron spectral energy during the year 1997 to 2011. The electron spectral energies were 0.038–0.315 MeV from EPAM instrument onboard ACE satellite and >2 MeV from GOES satellite. We found that the low electron energy has no correlation with high energy. In spite of we have corrected to the altitude differences. It implied that they originated from time dependent events with different sources and physical processes at the solar atmosphere. The sources of multi spectral energetic electron were related to flare and CME phenomena. However, we also found that high energetic electron comes from coronal hole.

  3. Chemical rocket propulsion a comprehensive survey of energetic materials

    CERN Document Server

    Shimada, Toru; Sinditskii, Valery; Calabro, Max

    2017-01-01

    Developed and expanded from the work presented at the New Energetic Materials and Propulsion Techniques for Space Exploration workshop in June 2014, this book contains new scientific results, up-to-date reviews, and inspiring perspectives in a number of areas related to the energetic aspects of chemical rocket propulsion. This collection covers the entire life of energetic materials from their conceptual formulation to practical manufacturing; it includes coverage of theoretical and experimental ballistics, performance properties, as well as laboratory-scale and full system-scale, handling, hazards, environment, ageing, and disposal. Chemical Rocket Propulsion is a unique work, where a selection of accomplished experts from the pioneering era of space propulsion and current technologists from the most advanced international laboratories discuss the future of chemical rocket propulsion for access to, and exploration of, space. It will be of interest to both postgraduate and final-year undergraduate students in...

  4. Effect of energetic oxygen atoms on neutral density models.

    Science.gov (United States)

    Rohrbaugh, R. P.; Nisbet, J. S.

    1973-01-01

    The dissociative recombination of O2(+) and NO(+) in the F region results in the production of atomic oxygen and atomic nitrogen with substantially greater kinetic energy than the ambient atoms. In the exosphere these energetic atoms have long free paths. They can ascend to altitudes of several thousand kilometers and can travel horizontally to distances of the order of the earth's radius. The distribution of energetic oxygen atoms is derived by means of models of the ion and neutral densities for quiet and disturbed solar conditions. A distribution technique is used to study the motion of the atoms in the collision-dominated region. Ballistic trajectories are calculated in the spherical gravitational field of the earth. The present calculations show that the number densities of energetic oxygen atoms predominate over the ambient atomic oxygen densities above 1000 km under quiet solar conditions and above 1600 km under disturbed solar conditions.

  5. Effect of Energetic Electrons on Quiet Auroral Arc Formation

    Science.gov (United States)

    Hasegawa, Hiroki; Ohno, Nobuaki; Sato, Tetsuya

    2010-11-01

    The theory of feedback instability between the magnetosphere and ionosphere is believed as one of the candidate to explain the formation of quiet auroral arc. Then, some magneto-hydro- dynamics simulations showed the arc formation by this macroscopic instability, while the effect of auroral energetic electrons on the arc formation was neglected or given as a macroscopic parameter in these simulations. On the other hand, because of the recent development of particle simulations, auroral energetic electrons are thought to be produced by the super ion-acoustic double layer that should be created by microscopic instability. To make close investigation of auroral arc formation, it is necessary to consider the interaction with microscopic instability. In this paper, we numerically study the effect of energetic electrons on quiet auroral arc formation by means of the Macro-Micro Interlocked simulation.

  6. Kinetic Simulation and Energetic Neutral Atom Imaging of the Magnetosphere

    Science.gov (United States)

    Fok, Mei-Ching H.

    2011-01-01

    Advanced simulation tools and measurement techniques have been developed to study the dynamic magnetosphere and its response to drivers in the solar wind. The Comprehensive Ring Current Model (CRCM) is a kinetic code that solves the 3D distribution in space, energy and pitch-angle information of energetic ions and electrons. Energetic Neutral Atom (ENA) imagers have been carried in past and current satellite missions. Global morphology of energetic ions were revealed by the observed ENA images. We have combined simulation and ENA analysis techniques to study the development of ring current ions during magnetic storms and substorms. We identify the timing and location of particle injection and loss. We examine the evolution of ion energy and pitch-angle distribution during different phases of a storm. In this talk we will discuss the findings from our ring current studies and how our simulation and ENA analysis tools can be applied to the upcoming TRIO-CINAMA mission.

  7. Mediterranean Diet Effect: an Italian picture

    Directory of Open Access Journals (Sweden)

    Azzini Elena

    2011-11-01

    Full Text Available Abstract Background The purpose of this study was to evaluate the overall diet quality effects, mainly on antioxidant nutritional status and some cytokines related to the cellular immune response as well as oxidative stress in a healthy Italian population group. Methods An observational study was conducted on 131 healthy free-living subjects. Dietary intake was assessed by dietary diary. Standardised procedures were used to make anthropometric measurements. On blood samples (serum, plasma and whole blood were evaluated: antioxidant status by vitamin A, vitamin E, carotenoids, vitamin C, uric acid, SH groups, SOD and GPx activities; lipid blood profile by total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides; total antioxidant capacity by FRAP and TRAP; the immune status by TNF-α, and IL-10 cytokines; the levels of malondialdehyde in the erythrocytes as marker of lipid peroxidation. Results The daily macronutrients intake (g/day have shown a high lipids consumption and significant differences between the sexes with regard to daily micronutrients intake. On total sample mean Mediterranean Diet Score (MDS was 4.5 ± 1.6 and no significant differences between the sexes were present. A greater adherence to a Mediterranean dietary pattern increases the circulating plasma levels of carotenoids (lutein plus zeaxanthin, cryptoxanthin, α and β-carotene, vitamin A and vitamin E. The levels of endogenous antioxidants were also improved. We observed higher levels in anti-inflammatory effect cytokines (IL-10 in subjects with MDS ≥ 6, by contrast, subjects with MDS ≤ 3 show higher levels in sense of proinflammatory (TNF α P 4. Our data suggest a protective role of vitamin A against chronic inflammatory conditions especially in subjects with the highest adherence to the Mediterranean-type dietary pattern. Conclusions Mediterranean dietary pattern is associated with significant amelioration of multiple risk factors, including a better

  8. Higher-order-mode fiber optimized for energetic soliton propagation.

    Science.gov (United States)

    Pedersen, Martin E V; Cheng, Ji; Charan, Kriti; Wang, Ke; Xu, Chris; Grüner-Nielsen, Lars; Jakobsen, Dan

    2012-08-15

    We describe the design optimization of a higher-order-mode (HOM) fiber for energetic soliton propagation at wavelengths below 1300 nm. A new HOM fiber is fabricated according to our design criteria. The HOM fiber is pumped at 1045 nm by an energetic femtosecond fiber laser. The soliton self-frequency shift process shifts the center wavelength of the soliton to 1085 nm. The soliton has a temporal duration of 216 fs and a pulse energy of 6.3 nJ. The demonstrated pulse energy is approximately six times higher than the previous record in a solid core fiber at wavelengths below 1300 nm.

  9. MOISTURE HUMIDITY EQUILIBRIUM OF WOOD CHIPS FROM ENERGETIC CROPS

    Directory of Open Access Journals (Sweden)

    Jan Barwicki

    2008-09-01

    Full Text Available Processes occurring during storage of wood chips for energetic or furniture industry purposes were presented. As a result of carried out investigations, dependences of temperature and relative humidity changes of surrounding air were shown. Modified Henderson equation can be utilized for computer simulation of storing and drying processes concerning wood chips for energetic and furniture industry purposes. It reflects also obtained results from experiments carried out with above mentioned material. Using computer simulation program we can examine different wood chips storing conditions to avoid overheating and loss problems.

  10. ENERGETIC EXTREMES IN REEF FISH OCCUPYING HARSH HABITATS

    DEFF Research Database (Denmark)

    Steffensen, John Fleng

    2009-01-01

    document how relatively small changes in fin morphology has afforded some coral reef fish taxa with exceptional locomotor performance and energetic efficiency, and how this key attribute may have played a key role in the evolution and ecology of several diverse Indo-Pacific reef fish families. Using......-finned counterparts. We discuss how such differences in locomotor efficiency are pivotal to the habitat-use of these fishes, and how eco-energetic models may be used to provide new insights into spatial variations in fish demography and ecology among coral reef habitat zones....

  11. Origins of energetic ions in the Earth's magnetosheath

    Science.gov (United States)

    1994-01-01

    This final report describes activities under NASA contract NAS5-31213 to Lockheed Missiles and Space Company. The report covers the entire contract period from 8 May 1991 to 7 Jun. 1994. This is a contract under the NASA Guest Investigator Program for the analysis and interpretation of the combined scientific data from the Hot Plasma Composition Experiment (HPCE) and the Charge Energy Mass (CHEM) spectrometer on the AMPTE/Charge Composition Explorer (CCE) spacecraft. These combined data sets have been used to survey the energetic ion environment in the earth's magnetosheath to determine the origins and relative strengths of the energetic ion populations found there.

  12. Origins of energetic ions in the Earth's magnetosheath

    Science.gov (United States)

    1994-06-01

    This final report describes activities under NASA contract NAS5-31213 to Lockheed Missiles and Space Company. The report covers the entire contract period from 8 May 1991 to 7 Jun. 1994. This is a contract under the NASA Guest Investigator Program for the analysis and interpretation of the combined scientific data from the Hot Plasma Composition Experiment (HPCE) and the Charge Energy Mass (CHEM) spectrometer on the AMPTE/Charge Composition Explorer (CCE) spacecraft. These combined data sets have been used to survey the energetic ion environment in the earth's magnetosheath to determine the origins and relative strengths of the energetic ion populations found there.

  13. The modified atkins diet in refractory epilepsy.

    Science.gov (United States)

    Sharma, Suvasini; Jain, Puneet

    2014-01-01

    The modified Atkins diet is a less restrictive variation of the ketogenic diet. This diet is started on an outpatient basis without a fast, allows unlimited protein and fat, and does not restrict calories or fluids. Recent studies have shown good efficacy and tolerability of this diet in refractory epilepsy. In this review, we discuss the use of the modified Atkins diet in refractory epilepsy.

  14. The Modified Atkins Diet in Refractory Epilepsy

    Directory of Open Access Journals (Sweden)

    Suvasini Sharma

    2014-01-01

    Full Text Available The modified Atkins diet is a less restrictive variation of the ketogenic diet. This diet is started on an outpatient basis without a fast, allows unlimited protein and fat, and does not restrict calories or fluids. Recent studies have shown good efficacy and tolerability of this diet in refractory epilepsy. In this review, we discuss the use of the modified Atkins diet in refractory epilepsy.

  15. Reversibly assembled cellular composite materials.

    Science.gov (United States)

    Cheung, Kenneth C; Gershenfeld, Neil

    2013-09-13

    We introduce composite materials made by reversibly assembling a three-dimensional lattice of mass-produced carbon fiber-reinforced polymer composite parts with integrated mechanical interlocking connections. The resulting cellular composite materials can respond as an elastic solid with an extremely large measured modulus for an ultralight material (12.3 megapascals at a density of 7.2 milligrams per cubic centimeter). These materials offer a hierarchical decomposition in modeling, with bulk properties that can be predicted from component measurements and deformation modes that can be determined by the placement of part types. Because site locations are locally constrained, structures can be produced in a relative assembly process that merges desirable features of fiber composites, cellular materials, and additive manufacturing.

  16. Glycosylation regulates prestin cellular activity.

    Science.gov (United States)

    Rajagopalan, Lavanya; Organ-Darling, Louise E; Liu, Haiying; Davidson, Amy L; Raphael, Robert M; Brownell, William E; Pereira, Fred A

    2010-03-01

    Glycosylation is a common post-translational modification of proteins and is implicated in a variety of cellular functions including protein folding, degradation, sorting and trafficking, and membrane protein recycling. The membrane protein prestin is an essential component of the membrane-based motor driving electromotility changes (electromotility) in the outer hair cell (OHC), a central process in auditory transduction. Prestin was earlier identified to possess two N-glycosylation sites (N163, N166) that, when mutated, marginally affect prestin nonlinear capacitance (NLC) function in cultured cells. Here, we show that the double mutant prestin(NN163/166AA) is not glycosylated and shows the expected NLC properties in the untreated and cholesterol-depleted HEK 293 cell model. In addition, unlike WT prestin that readily forms oligomers, prestin(NN163/166AA) is enriched as monomers and more mobile in the plasma membrane, suggesting that oligomerization of prestin is dependent on glycosylation but is not essential for the generation of NLC in HEK 293 cells. However, in the presence of increased membrane cholesterol, unlike the hyperpolarizing shift in NLC seen with WT prestin, cells expressing prestin(NN163/166AA) exhibit a linear capacitance function. In an attempt to explain this finding, we discovered that both WT prestin and prestin(NN163/166AA) participate in cholesterol-dependent cellular trafficking. In contrast to WT prestin, prestin(NN163/166AA) shows a significant cholesterol-dependent decrease in cell-surface expression, which may explain the loss of NLC function. Based on our observations, we conclude that glycosylation regulates self-association and cellular trafficking of prestin(NN163/166AA). These observations are the first to implicate a regulatory role for cellular trafficking and sorting in prestin function. We speculate that the cholesterol regulation of prestin occurs through localization to and internalization from membrane microdomains by

  17. Stochastic Nature in Cellular Processes

    Institute of Scientific and Technical Information of China (English)

    刘波; 刘圣君; 王祺; 晏世伟; 耿轶钊; SAKATA Fumihiko; GAO Xing-Fa

    2011-01-01

    The importance of stochasticity in cellular processes is increasingly recognized in both theoretical and experimental studies. General features of stochasticity in gene regulation and expression are briefly reviewed in this article, which include the main experimental phenomena, classification, quantization and regulation of noises. The correlation and transmission of noise in cascade networks are analyzed further and the stochastic simulation methods that can capture effects of intrinsic and extrinsic noise are described.

  18. Cellular fiber–reinforced concrete

    OpenAIRE

    Isachenko S.; Kodzoev M.

    2016-01-01

    Methods disperse reinforcement of concrete matrix using polypropylene, glass, basalt and metal fibers allows to make the construction of complex configuration, solve the problem of frost products. Dispersed reinforcement reduces the overall weight of the structures. The fiber replaces the secondary reinforcement, reducing the volume of use of structural steel reinforcement. Cellular Fiber concretes are characterized by high-performance properties, especially increased bending strength and...

  19. Identification of Nonstationary Cellular Automata

    Institute of Scientific and Technical Information of China (English)

    AndrewI.Adamatzky

    1992-01-01

    The principal feature of nonstationary cellular automata(NCA) is that a local transitiol rule of each cell is changed at each time step depending on neighborhood configuration at previous time step.The identification problem for NCA is extraction of local transition rules and the establishment of mechanism for changing these rules using sequence of NCA configurations.We present serial and parallel algorithms for identification of NCA.

  20. CELLULAR INTERACTIONS MEDIATED BY GLYCONECTIDS

    OpenAIRE

    Popescu, O.; Sumanovski, L. T.; I. Checiu; Elisabeta Popescu; G. N. Misevic

    1999-01-01

    Cellular interactions involve many types of cell surface molecules and operate via homophilic and/or heterophilic protein-protein and protein-carbohydrate binding. Our investigations in different model-systems (marine invertebrates and mammals) have provided direct evidence that a novel class of primordial proteoglycans, named by us gliconectins, can mediate cell adhesion via a new alternative molecular mechanism of polyvalent carbohydrate-carbohydrate binding. Biochemical characterization of...

  1. Health benefits of the Mediterranean Diet: an update of research over the last 5 years.

    Science.gov (United States)

    Gotsis, Efthymios; Anagnostis, Panagiotis; Mariolis, Anargyros; Vlachou, Athanasia; Katsiki, Niki; Karagiannis, Asterios

    2015-04-01

    The Mediterranean Diet (MedDiet) has been reported to be protective against the occurrence of several diseases. Increasing evidence suggests that the MedDiet could counter diseases associated with chronic inflammation, including metabolic syndrome, atherosclerosis, cancer, diabetes, obesity, pulmonary diseases, and cognition disorders. Adoption of a MedDiet was associated with beneficial effects on the secretion of anti-inflammatory cytokines, antioxidant cellular and circulating biomarkers as well as with regulation of gene polymorphisms involved in the atherosclerotic process. The MedDiet has been considered for the prevention of cardiovascular and other chronic degenerative diseases focusing on the impact of a holistic dietary approach rather than on single nutrients. Epidemiological dietary scores measuring adherence to a MedDiet have been developed. This narrative review considers the results of up-to-date clinical studies (with a focus on the last 5 years) that evaluated the effectiveness of the MedDiet in reducing the prevalence of chronic and degenerative diseases.

  2. The insect cellular immune response

    Institute of Scientific and Technical Information of China (English)

    Michael R. Strand

    2008-01-01

    The innate immune system of insects is divided into humoral defenses that include the production of soluble effector molecules and cellular defenses like phagocytosis and encapsulation that are mediated by hemocytes. This review summarizes current understanding of the cellular immune response. Insects produce several terminally differentiated types of hemocytes that are distinguished by morphology, molecular and antigenic markers, and function. The differentiated hemocytes that circulate in larval or nymphal stage insects arise from two sources: progenitor cells produced during embryogenesis and mesodermally derived hematopoietic organs. Regulation of hematopoiesis and hemocyte differentiation also involves several different signaling pathways. Phagocytosis and encapsulation require that hemocytes first recognize a given target as foreign followed by activation of downstream signaling and effector responses. A number of humoral and cellular receptors have been identified that recognize different microbes and multicellular parasites. In turn, activation of these receptors stimulates a number of signaling pathways that regulate different hemocyte functions. Recent studies also identify hemocytes as important sources of a number of humoral effector molecules required for killing different foreign invaders.

  3. Progress of cellular dedifferentiation research

    Institute of Scientific and Technical Information of China (English)

    LIU Hu-xian; HU Da-hai; JIA Chi-yu; FU Xiao-bing

    2006-01-01

    Differentiation, the stepwise specialization of cells, and transdifferentiation, the apparent switching of one cell type into another, capture much of the stem cell spotlight. But dedifferentiation, the developmental reversal of a cell before it reinvents itself, is an important process too. In multicellular organisms, cellular dedifferentiation is the major process underlying totipotency, regeneration and formation of new stem cell lineages. In humans,dedifferentiation is often associated with carcinogenesis.The study of cellular dedifferentiation in animals,particularly early events related to cell fate-switch and determination, is limited by the lack of a suitable,convenient experimental system. The classic example of dedifferentiation is limb and tail regeneration in urodele amphibians, such as salamanders. Recently, several investigators have shown that certain mammalian cell types can be induced to dedifferentiate to progenitor cells when stimulated with the appropriate signals or materials. These discoveries open the possibility that researchers might enhance the endogenous regenerative capacity of mammals by inducing cellular dedifferentiation in vivo.

  4. Energetics of lateral eddy diffusion/advection:Part I. Thermodynamics and energetics of vertical eddy diffusion

    Institute of Scientific and Technical Information of China (English)

    HUANG Rui Xin

    2014-01-01

    Two important nonlinear properties of seawater thermodynamics linked to changes of water density, cab-beling and elasticity (compressibility), are discussed. Eddy diffusion and advection lead to changes in den-sity;as a result, gravitational potential energy of the system is changed. Therefore, cabbeling and elasticity play key roles in the energetics of lateral eddy diffusion and advection. Vertical eddy diffusion is one of the key elements in the mechanical energy balance of the global oceans. Vertical eddy diffusion can be con-ceptually separated into two steps:stirring and subscale diffusion. Vertical eddy stirring pushes cold/dense water upward and warm/light water downward;thus, gravitational potential energy is increased. During the second steps, water masses from different places mix through subscale diffusion, and water density is increased due to cabbeling. Using WOA01 climatology and assuming the vertical eddy diffusivity is equal to a constant value of 2×103 Pa2/s, the total amount of gravitational potential energy increase due to vertical stirring in the world oceans is estimated at 263 GW. Cabbeling associated with vertical subscale diffusion is a sink of gravitational potential energy, and the total value of energy lost is estimated at 73 GW. Therefore, the net source of gravitational potential energy due to vertical eddy diffusion for the world oceans is estimated at 189 GW.

  5. Diet, Nutrition, and Cancer Epigenetics.

    Science.gov (United States)

    Sapienza, Carmen; Issa, Jean-Pierre

    2016-07-17

    The search for a connection between diet and human cancer has a long history in cancer research, as has interest in the mechanisms by which dietary factors might increase or decrease cancer risk. The realization that altering diet can alter the epigenetic state of genes and that these epigenetic alterations might increase or decrease cancer risk is a more modern notion, driven largely by studies in animal models. The connections between diet and epigenetic alterations, on the one hand, and between epigenetic alterations and cancer, on the other, are supported by both observational studies in humans as well as animal models. However, the conclusion that diet is linked directly to epigenetic alterations and that these epigenetic alterations directly increase or decrease the risk of human cancer is much less certain. We suggest that true and measurable effects of diet or dietary supplements on epigenotype and cancer risk are most likely to be observed in longitudinal studies and at the extremes of the intersection of dietary risk factors and human population variability. Careful analysis of such outlier populations is most likely to shed light on the molecular mechanisms by which suspected environmental risk factors drive the process of carcinogenesis.

  6. Cellular communications a comprehensive and practical guide

    CERN Document Server

    Tripathi, Nishith

    2014-01-01

    Even as newer cellular technologies and standards emerge, many of the fundamental principles and the components of the cellular network remain the same. Presenting a simple yet comprehensive view of cellular communications technologies, Cellular Communications provides an end-to-end perspective of cellular operations, ranging from physical layer details to call set-up and from the radio network to the core network. This self-contained source forpractitioners and students represents a comprehensive survey of the fundamentals of cellular communications and the landscape of commercially deployed

  7. Guidance for Soil Sampling for Energetics and Metals

    Science.gov (United States)

    2011-10-01

    66  8.4  Processing for PAHs , perchlorate, WP...Detonation PAH Polycyclic Aromatic Hydrocarbon PE Performance Evaluation QA Quality Assurance QC Quality Control RCRA Resource Conservation and...presence of energetic compounds in groundwater (e.g., Martel et al. 2009). We think that all of these compounds biotransform and biodegrade once they are

  8. MMRP Guidance Document for Soil Sampling of Energetics and Metals

    Science.gov (United States)

    2011-10-01

    66  8.4  Processing for PAHs , perchlorate, WP...Detonation PAH Polycyclic Aromatic Hydrocarbon PE Performance Evaluation QA Quality Assurance QC Quality Control RCRA Resource Conservation and...presence of energetic compounds in groundwater (e.g., Martel et al. 2009). We think that all of these compounds biotransform and biodegrade once they are

  9. The energetics of organic synthesis inside and outside the cell.

    Science.gov (United States)

    Amend, Jan P; LaRowe, Douglas E; McCollom, Thomas M; Shock, Everett L

    2013-07-19

    Thermodynamic modelling of organic synthesis has largely been focused on deep-sea hydrothermal systems. When seawater mixes with hydrothermal fluids, redox gradients are established that serve as potential energy sources for the formation of organic compounds and biomolecules from inorganic starting materials. This energetic drive, which varies substantially depending on the type of host rock, is present and available both for abiotic (outside the cell) and biotic (inside the cell) processes. Here, we review and interpret a library of theoretical studies that target organic synthesis energetics. The biogeochemical scenarios evaluated include those in present-day hydrothermal systems and in putative early Earth environments. It is consistently and repeatedly shown in these studies that the formation of relatively simple organic compounds and biomolecules can be energy-yielding (exergonic) at conditions that occur in hydrothermal systems. Expanding on our ability to calculate biomass synthesis energetics, we also present here a new approach for estimating the energetics of polymerization reactions, specifically those associated with polypeptide formation from the requisite amino acids.

  10. The energetic and chemical signatures of persistent soil organic matter

    DEFF Research Database (Denmark)

    Barré, Pierre; Plante, Alain F.; Cecillon, Lauric

    2016-01-01

    to accurately predict soil OM stock evolution under climate and land-use changes. Using a unique set of historic soil samples from five long-term (27–79 years) bare fallow experiments, we demonstrate that despite wide pedo-climatic diversity, persistent OM shows specific energetic signatures, but no uniform...

  11. Energetic Particle Pressure at Interplanetary Shocks: STEREO-A Observations

    CERN Document Server

    Lario, D; Roelof, E C; Vinas, A -F

    2015-01-01

    We study periods of elevated energetic particle intensities observed by STEREO-A when the partial pressure exerted by energetic ($\\geq$83 keV) protons ($P_{EP}$) is larger than the pressure exerted by the interplanetary magnetic field ($P_{B}$). In the majority of cases, these periods are associated with the passage of interplanetary shocks. Periods when $P_{EP}$ exceeds $P_{B}$ by more than one order of magnitude are observed in the upstream region of fast interplanetary shocks where depressed magnetic field regions coincide with increases of the energetic particle intensities. When solar wind parameters are available, $P_{EP}$ also exceeds the pressure exerted by the solar wind thermal population ($P_{TH}$). Prolonged periods ($>$12 h) with both $P_{EP}$$>$$P_{B}$ and $P_{EP}$$>$$P_{TH}$ may also occur when energetic particles accelerated by an approaching shock encounter a region well-upstream of the shock characterized by low magnetic field magnitude and tenuous solar wind density. Quasi-exponential incre...

  12. Biomechanics and energetics of running on uneven terrain.

    Science.gov (United States)

    Voloshina, Alexandra S; Ferris, Daniel P

    2015-03-01

    In the natural world, legged animals regularly run across uneven terrain with remarkable ease. To gain understanding of how running on uneven terrain affects the biomechanics and energetics of locomotion, we studied human subjects (N=12) running at 2.3 m s(-1) on an uneven terrain treadmill, with up to a 2.5 cm height variation. We hypothesized that running on uneven terrain would show increased energy expenditure, step parameter variability and leg stiffness compared with running on smooth terrain. Subject energy expenditure increased by 5% (0.68 W kg(-1); Prunning on uneven terrain compared with smooth terrain. Step width and length variability also increased by 27% and 26%, respectively (Prunning on uneven terrain compared with smooth terrain. Calculations of gravitational potential energy fluctuations suggest that about half of the energetic increases can be explained by additional positive and negative mechanical work for up and down steps on the uneven surface. This is consistent between walking and running, as the absolute increases in energetic cost for walking and running on uneven terrain were similar: 0.68 and 0.48 W kg(-1), respectively. These results provide insight into how surface smoothness can affect locomotion biomechanics and energetics in the real world.

  13. Kinetic effects of energetic particles on resistive MHD stability.

    Science.gov (United States)

    Takahashi, R; Brennan, D P; Kim, C C

    2009-04-03

    We show that the kinetic effects of energetic particles can play a crucial role in the stability of the m/n=2/1 tearing mode in tokamaks (e.g., JET, JT-60U, and DIII-D), where the fraction of energetic particle beta(frac) is high. Using model equilibria based on DIII-D experimental reconstructions, the nonideal MHD linear stability of cases unstable to the 2/1 mode is investigated including a deltaf particle-in-cell model for the energetic particles coupled to the nonlinear 3D resistive MHD code NIMROD [C. C. Kim et al., Phys. Plasmas 15, 072507 (2008)10.1063/1.2949704]. It is observed that energetic particles have significant damping and stabilizing effects at experimentally relevant beta, beta(frac), and S, and excite a real frequency of the 2/1 mode. Extrapolation of the results is discussed for implications to JET and ITER, where the effects are projected to be significant.

  14. Energetic bottlenecks and other design constraints in avian annual cycles

    NARCIS (Netherlands)

    Piersma, T

    2002-01-01

    The flexible phenotypes of birds and mammals often appear to represent adjustments to alleviate some energetic bottleneck or another. By increasing the size of the organs involved in digestion and assimilation of nutrients (gut and liver), an individual bird can increase its ability to process nutri

  15. The energetics of organic synthesis inside and outside the cell

    Science.gov (United States)

    Amend, Jan P.; LaRowe, Douglas E.; McCollom, Thomas M.; Shock, Everett L.

    2013-01-01

    Thermodynamic modelling of organic synthesis has largely been focused on deep-sea hydrothermal systems. When seawater mixes with hydrothermal fluids, redox gradients are established that serve as potential energy sources for the formation of organic compounds and biomolecules from inorganic starting materials. This energetic drive, which varies substantially depending on the type of host rock, is present and available both for abiotic (outside the cell) and biotic (inside the cell) processes. Here, we review and interpret a library of theoretical studies that target organic synthesis energetics. The biogeochemical scenarios evaluated include those in present-day hydrothermal systems and in putative early Earth environments. It is consistently and repeatedly shown in these studies that the formation of relatively simple organic compounds and biomolecules can be energy-yielding (exergonic) at conditions that occur in hydrothermal systems. Expanding on our ability to calculate biomass synthesis energetics, we also present here a new approach for estimating the energetics of polymerization reactions, specifically those associated with polypeptide formation from the requisite amino acids. PMID:23754809

  16. The Prudent Parent : Energetic Adjustments in Avian Breeding

    NARCIS (Netherlands)

    Drent, R.H.; Daan, S.

    1980-01-01

    1. Energetics of reproduction in birds is reviewed with the question in mind how the parent adjusts its effort in relation to prevailing environmental conditions in order to maximize the output of young in its lifetime. Emphasis is on proximate controls, rather than ultimate factors measurable in te

  17. Evolution of clusters in energetic heavy ion bombarded amorphous graphite

    CERN Document Server

    Akhtar, M N; Ahmad, Shoaib

    2016-01-01

    Carbon clusters have been generated by a novel technique of energetic heavy ion bombardment of amorphous graphite. The evolution of clusters and their subsequent fragmentation under continuing ion bombardment is revealed by detecting various clusters in the energy spectra of the direct recoils emitted as a result of collision between ions and the surface constituents.

  18. Doing Wholeness, Producing Subjects: Kinesiological Sensemaking and Energetic Kinship

    DEFF Research Database (Denmark)

    Gruenenberg, Kristina; Hillersdal, Line; Walker, Hanne Kjaergaard;

    2013-01-01

    and disconnections, which are conceptualized and practised within kinesiology. We attempt to come to grips with these specific notions of relatedness through the introduction of the concept energetic kinship' and to relate them to more general discussions about the nature of subjects, bodies and social identity...

  19. Preparation and characterization of GA/RDX nanostructured energetic composites

    Indian Academy of Sciences (India)

    YUANFEI LAN; XUEBAO WANG; YUNJUN LUO

    2016-12-01

    Graphene aerogel (GA) with nano-porous structure was assembled through the formation of physical cross-links between graphene sheets by a facile sol–gel method and supercritical CO$_2$ drying process. Thenhexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was added and trapped in the nano-porous three-dimensional networks of GA to obtain a novel GA/RDX nanostructured energetic composite. The composition, morphology andstructure of the obtained GA/RDX nanostructured energetic composite were characterized by elemental analysis, scanning electron microscopy, nitrogen sorption tests and X-ray diffraction. Moreover, the thermal decompositioncharacteristic was investigated by thermogravimetry and differential scanning calorimetry. The results showed that GA could be a perfect aerogel matrix for the fabrication of GA/RDX nanostructured energetic composite due to itsunique nano-porous structure and attributes. It was also demonstrated that RDX homogeneously disperses in the asprepared GA/RDX nanostructured energetic composite at nanometric scale. GA showed promising catalytic effects for the thermal decomposition of RDX. After incorporating with GA, the decomposition of RDX was obviously accelerated.

  20. Energetic Argument for Bimodal Black Hole Accretion discs

    Institute of Scientific and Technical Information of China (English)

    林一清; 卢炬甫; 顾为民

    2002-01-01

    Based on simple energetic considerations, we show that two crucial ingredients of bimodal black hole accretiondiscs, namely the sonic point and the transition radius, can be determined from the disc constant parameters.Thus, we can further justify the model of bimodal discs containing thermal instability triggered transition.

  1. Decay Rate of Energy Eigenfunctions in Classically Energetically Inaccessible Regions

    Institute of Scientific and Technical Information of China (English)

    WANG Wen-Ge

    2004-01-01

    Classically energetically inaccessible parts of energy eigenfunctions in configuration space are studied by making use of a generalization of Brillouin-Wigner perturbation theory. Approximate formulas are proposed for describing local decaying rate of this part of energy eigenfunctions, which are useful in the study of quantum phenomena,such as tunnelling effect, and are tested in an anharmonic oscillator.

  2. Propulsion and energetic materials research in the Netherlands

    NARCIS (Netherlands)

    Zevenbergen, J.F.; Pekalski, A.A.; Heijden, A.E.D.M. van der; Keizers, H.L.J.; Berg, R.P. van den; Maree, A.G.M.; Vliet, L.D. van; Welland, W.H.M.; Wierckx, F.J.M.

    2005-01-01

    Fundamental research on new and existing propellant formulations and energetic materials in the Netherlands is essentially carried out by the Delft University of Technology, Utrecht University, the Dutch Defense Laboratory ‘TNO Defense Security and Safety’ and the SME Aerospace Propulsion Products.

  3. Kinetics and energetics of producing animal-manure-based biochar

    Science.gov (United States)

    Pyrolysis of animal manure produce biochar with multiple beneficial use potentials for improving soil quality and the environment. The kinetics and energetics of pyrolysis in producing manure-based biochar char were reviewed and analyzed. Kinetic analysis of pyrolysis showed that the higher the temp...

  4. Solar Energetic Particle Precipitation Effects on the ionosphere of Mars

    Science.gov (United States)

    Lillis, Robert; Larson, Davin; Luhmann, Janet; Lee, Christina; Jakosky, Bruce

    2016-10-01

    Solar Energetic Particles (SEPs) are an important, if irregular, source of ionization and energy input to the Martian atmosphere. As is the case for much-studied Polar Cap precipitation events on the earth, when SEPs precipitate into the Mars atmosphere, they cause heating, ionization, excitation and dissociation, leading to altitude-dependent changes in chemistry. We present a study of the effects of SEP ionization in the Martian atmosphere using data from the Mars Atmosphere and Volatile Evolution (MAVEN) mission. Specifically, we will correlate altitude profiles of thermal planetary ions (O+, CO2+ and O2+) and electrons measured by the Neutral Gas and Ion Mass Spectrometer (NGIMS) and Langmuir Probe on the MAVEN spacecraft with fluxes of energetic protons and electrons measured by the Solar Energetic Particle (SEP) detector. First, we will present case studies of this correlation, before and during SEP events to examine short-term effects of SEP ionization. We will also examine SEP ionization under different heliospheric conditions, leading to different SEP shadowing geometries and ionization rates. Second, we will present a statistical study showing the degree to which ionospheric densities are affected by the presence of energetic particles, as a function of altitude, SEP spectrum flux and solar zenith angle. This work will provide a better understanding of this important source of ionization in the Martian upper atmosphere and hence, how more frequent and more intense SEP events in Mars' past may have affected the structure of the Martian upper atmosphere and hence atmospheric escape.

  5. New fluidized bed reactor for coating of energetic materials

    NARCIS (Netherlands)

    Abadjieva, E.; Huijser, T.; Creyghton, Y.L.M.; Heijden, A.E.D.M. van der

    2009-01-01

    The process of altering and changing the properties of the energetic materials by coating has been studied extensively by several scientific groups. According to the desired application different coating techniques have been developed and applied to achieve satisfactory results. Among the already de

  6. Solar Source Regions of Energetic 3He Emission

    Science.gov (United States)

    Mason, G. M.; Nitta, N. V.; Cohen, C. M.; Wiedenbeck, M. E.

    2012-12-01

    One of the surprising observations from the ACE mission has been the detection of energetic 3He emission occurring over multi-day periods. Previously observations of solar energetic 3He had detected short-lived "impulsive" energetic particle events which were associated with type III bursts and energetic electrons. The ACE observations were able to detect 3He at very low levels (<1% of 4He compared to ~10% in most earlier work) and this showed that the impulsive events often occurred during seemingly continuous multi-day periods of 3He emission. During solar active periods, 3He was present at 1 AU the majority of the time, giving evidence for either semi-continuous processes or else unresolved multiple small injections. The obvious injections during such periods were strongly associated with jet activity By adding STEREO and SDO observations we are seeking to extend the observational picture for these events. First, by following single 3He emitting regions from STEREO-B to ACE to STEREO-A we seek to examine for how long the 3He emission can continue, since any single spacecraft can be magnetically connected to a single region for only a few days and ACE often sees emission periods of that length. Second, by using SDO-AIA we seek to probe further the properties of the emitting regions to see if the previously reported association with jets is seen in events which we can now observe with greater resolution, sensitivity, and cadence than previously possible.

  7. Energetics of Sensing and Communication in Electric Fish: A Blessing and a Curse in the Anthropocene?

    Science.gov (United States)

    Markham, Michael R; Ban, Yue; McCauley, Austin G; Maltby, Rosalie

    2016-11-01

    Weakly electric freshwater fish use self-generated electric fields to image their worlds and communicate in the darkness of night and turbid waters. This active sensory/communication modality evolved independently in the freshwaters of South America and Africa, where hundreds of electric fish species are broadly and abundantly distributed. The adaptive advantages of the sensory capacity to forage and communicate in visually-unfavorable environments and outside the detection of visually-guided predators likely contributed to the broad success of these clades across a variety of Afrotropical and neotropical habitats. Here we consider the potentially high and limiting metabolic costs of the active sensory and communication signals that define the gymnotiform weakly electric fish of South America. Recent evidence from two well-studied species suggests that the metabolic costs of electrogenesis can be quite high, sometimes exceeding one-fourth of these fishes' daily energy budget. Supporting such an energetically expensive system has shaped a number of cellular, endocrine, and behavioral adaptations to restrain the metabolic costs of electrogenesis in general or in response to metabolic stress. Despite a suite of adaptations supporting electrogenesis, these weakly electric fish are vulnerable to metabolic stresses such as hypoxia and food restriction. In these conditions, fish reduce signal amplitude presumably as a function of absolute energy shortfall or as a proactive means to conserve energy. In either case, reducing signal amplitude compromises both sensory and communication performance. Such outcomes suggest that the higher metabolic cost of active sensing and communication in weakly electric fish compared with the sensory and communication systems in other neotropical fish might mean that weakly electric fish are disproportionately susceptible to harm from anthropogenic disturbances of neotropical aquatic habitats. Fully evaluating this possibility, however, will

  8. Energetics, Biomechanics, and Performance in Masters' Swimmers: A Systematic Review.

    Science.gov (United States)

    Ferreira, Maria I; Barbosa, Tiago M; Costa, Mário J; Neiva, Henrique P; Marinho, Daniel A

    2016-07-01

    Ferreira, MI, Barbosa, TM, Costa, MJ, Neiva, HP, and Marinho, DA. Energetics, biomechanics, and performance in masters' swimmers: a systematic review. J Strength Cond Res 30(7): 2069-2081, 2016-This study aimed to summarize evidence on masters' swimmers energetics, biomechanics, and performance gathered in selected studies. An expanded search was conducted on 6 databases, conference proceedings, and department files. Fifteen studies were selected for further analysis. A qualitative evaluation of the studies based on the Quality Index (QI) was performed by 2 independent reviewers. The studies were thereafter classified into 3 domains according to the reported data: performance (10 studies), energetics (4 studies), and biomechanics (6 studies). The selected 15 articles included in this review presented low QI scores (mean score, 10.47 points). The biomechanics domain obtained higher QI (11.5 points), followed by energetics and performance (10.6 and 9.9 points, respectively). Stroke frequency (SF) and stroke length (SL) were both influenced by aging, although SF is more affected than SL. Propelling efficiency (ηp) decreased with age. Swimming performance declined with age. The performance declines with age having male swimmers deliver better performances than female counterparts, although this difference tends to be narrow in long-distance events. One single longitudinal study is found in the literature reporting the changes in performance over time. The remaining studies are cross-sectional designs focusing on the energetics and biomechanics. Overall, biomechanics parameters, such as SF, SL, and ηp, tend to decrease with age. This review shows the lack of a solid body of knowledge (reflected in the amount and quality of the articles published) on the changes in biomechanics, energetics, and performance of master swimmers over time. The training programs for this age-group should aim to preserve the energetics as much as possible and, concurrently, improve the

  9. Organic diets are equally good for rainbow trout fry as conventional diets

    DEFF Research Database (Denmark)

    Madsen, Lone; Ingerslev, Hans Christian; Dalsgaard, Inger

    2014-01-01

    OPTIFISH has been to elucidate the effect of diet ingredients on fish health. Diets with either organic or non-organic ingredients were compared. The OPTIFISH project has shown that the ingredient type in the diet is more important for the bacterial intestinal microbiota of the fish than if the diet...... ingredients are of organic or conventional origin. Furthermore, fish fed organic diets appear to acquire the same health status as fish fed conventional diets....

  10. An evaluation of the atkins' diet.

    Science.gov (United States)

    Miller, Bernard V; Bertino, Joseph S; Reed, Roberta G; Burrington, Christine M; Davidson, Leslie K; Green, Allan; Gartung, Anne M; Nafziger, Anne N

    2003-12-01

    Low-carbohydrate (LC) weight-reducing diets are popular choices for self-dieters. Eighteen adults (BMI >/= 25 kg/m(2)) were enrolled in this short-term longitudinal study to evaluate dietary intake and weight on their "usual" diets and LC diet. Subjects were instructed to follow the first two phases of the diet described in Dr. Atkins' New Diet Revolution (2 weeks each). Total daily intake of calories and nutrients were calculated from 3-day food diaries. Body weight was measured at the end of each 2-week diet session. All enrolled subjects completed the study (age = 39.8 +/- 8.1 years, BMI = 36.6 +/- 6.6 kg/m(2)). Mean caloric intakes were 1400 +/- 472 kcal/day (Induction diet) and 1558 +/- 490 kcal/day (Ongoing Weight Loss diet) both p diet) 2481 +/- 723 kcal/day. Body weights were 107.4 +/- 24.2 kg, 103.6 +/- 23.0 kg and 102.1 +/- 22.6 kg at the conclusion of the Baseline, Induction, and Ongoing Weight Loss diets, respectively (both p diets versus "usual" diet. Caloric intake is decreased when otherwise healthy overweight and obese adults self-implement Atkins' Induction and Ongoing Weight Loss diets and significantly altered their dietary micronutrient intake. Weight loss can be explained by the self-selected lower caloric intake on The Atkins' Diet.

  11. Interplay between metabolic rate and diet quality in the South American fox, Pseudalopex culpaeus.

    Science.gov (United States)

    Silva, Sergio I; Jaksic, Fabian M; Bozinovic, Francisco

    2004-01-01

    We studied the metabolic costs associated with the ingestion of peppertree fruits (Schinus molle) in the culpeo fox, Pseudalopex culpaeus, the second largest canid in South America. Throughout its range of distribution, this fox feeds on rodents and other small vertebrates, and also on peppertree fruits, which represent 98% of total fruits consumed in semiarid Chile. Peppertree contains a high diversity of phytochemicals. Foxes feeding on diets containing rats and peppertree fruits (mixed diets) exhibited a 98.9% increase in basal rate of metabolism when compared to rat-acclimated foxes. Thus, acute ingestion of chemically defended fruits has an energetic cost for the fox, reflected in higher values of basal metabolism. Increased metabolic rates may be associated with increased protein synthesis for detoxification and for tissue repair, including the production of biotransformation enzymes.

  12. Energetic cost of insecticide resistance in Culex pipiens mosquitoes.

    Science.gov (United States)

    Rivero, A; Magaud, A; Nicot, A; Vézilier, J

    2011-05-01

    The extensive use of insecticides to control vector populations has lead to the widespread development of different mechanisms of insecticide resistance. Mutations that confer insecticide resistance are often associated to fitness costs that prevent them from spreading to fixation. In vectors, such fitness costs include reductions in preimaginal survival, adult size, longevity, and fecundity. The most commonly invoked explanation for the nature of such pleiotropic effects of insecticide resistance is the existence of resource-based trade-offs. According to this hypothesis, insecticide resistance would deplete the energetic stores of vectors, reducing the energy available for other biological functions and generating trade-offs between insecticide resistance and key life history traits. Here we test this hypothesis by quantifying the energetic resources (lipids, glycogen, and glucose) of larvae and adult females of the mosquito Culex pipiens L. resistant to insecticides through two different mechanisms: esterase overproduction and acetylcholinesterase modification. We find that, as expected from trade-off theory, insecticide resistant mosquitoes through the overproduction of esterases contain on average 30% less energetic reserves than their susceptible counterparts. Acetylcholinesterase-modified mosquitoes, however, also showed a significant reduction in energetic resources (20% less). We suggest that, in acetylcholinesterase-modified mosquitoes, resource depletion may not be the result of resource-based trade-offs but a consequence of the hyperactivation of the nervous system. We argue that these results not only provide a mechanistic explanation for the negative pleiotropic effects of insecticide resistance on mosquito life history traits but also can have a direct effect on the development of parasites that depend on the vector's energetic reserves to fulfil their own metabolic needs.

  13. Low-energy-density diets are associated with higher diet quality and higher diet costs in French adults.

    Science.gov (United States)

    Drewnowski, Adam; Monsivais, Pablo; Maillot, Matthieu; Darmon, Nicole

    2007-06-01

    Low-energy-density diets are often recommended for weight control. Such diets have a higher nutrient content than do high-energy-density diets. This study tested the hypothesis that energy-dense diets have a relatively low monetary cost, whereas less energy-dense diets are more expensive. In this cross-sectional study, dietary intakes of 1,474 French adults (672 men, 802 women), aged 15 to 92 years, were assessed using 7-day diet records. Dietary energy density (kcal/g) was calculated by dividing total dietary energy by the edible weight of foods and caloric beverages consumed. Diet cost ($/7 days or $/2,000 kcal) was estimated using mean national food prices for 895 foods. The relationship between dietary energy density and diet cost was examined in a linear regression model. Within each quintile of energy intakes, the more energy-dense diets were associated with lower diet quality and with lower diet costs (r(2)=0.38 to 0.44). In a regression model, the more energy-dense diets cost less, whereas low-energy-density diets cost substantially more, adjusting for energy intakes, sex, and age. The finding that energy-dense diets cost less per 2,000 kcal may help explain why the highest rates of obesity are observed among groups of limited economic means. The finding that low-energy-density diets are associated with higher diet costs suggests that lasting improvements in diet quality may require economic as well as behavioral interventions.

  14. Diet and epigenetics in colon cancer

    Institute of Scientific and Technical Information of China (English)

    Minna Nystr(o)m; Marja Mutanen

    2009-01-01

    Over the past few years, evidence has accumulated indicating that apart from genetic alterations, epigenetic alterations, through e.g. aberrant promoter methylation, play a major role in the initiation and progression of colorectal cancer (CRC). Even in the hereditary colon cancer syndromes, in which the susceptibility is inherited dominantly, cancer develops only as the result of the progressive accumulation of genetic and epigenetic alterations. Diet can both prevent and induce colon carcinogenesis, for instance, through epigenetic changes, which regulate the homeostasis of the intestinal mucosa. Food-derived compounds are constantly present in the intestine and may shift cellular balance toward harmful outcomes, such as increased susceptibility to mutations. There is strong evidence that a major component of cancer risk may involve epigenetic changes in normal cells that increase the probability of cancer after genetic mutation. The recognition of epigenetic changes as a driving force in colorectal neoplasia would open new areas of research in disease epidemiology, risk assessment, and treatment, especially in mutation carriers who already have an inherited predisposition to cancer.(c) 2009 The WJG Press and Baishideng. All rights reserved.

  15. High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress.

    Science.gov (United States)

    Balakumar, M; Raji, L; Prabhu, D; Sathishkumar, C; Prabu, P; Mohan, V; Balasubramanyam, M

    2016-12-01

    In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistance and metabolic disorders, there is lack of studies in relation to high-fructose diet. Therefore, we attempted to study the effect of different diets viz., high-fat diet (HFD), high-fructose diet (HFS), and a combination (HFS + HFD) diet on glucose homeostasis and insulin sensitivity in male Wistar rats compared to control animals fed with normal pellet diet. Investigations include oral glucose tolerance test, insulin tolerance test, histopathology by H&E and Masson's trichrome staining, mRNA expression by real-time PCR, protein expression by Western blot, and caspase-3 activity by colorimetry. Rats subjected to high-fat/fructose diets became glucose intolerant, insulin-resistant, and dyslipidemic. Compared to control animals, rats subjected to different combination of fat/fructose diets showed increased mRNA and protein expression of a battery of ER stress markers both in pancreas and liver. Transcription factors of β-cell function (INSIG1, SREBP1c and PDX1) as well as hepatic gluconeogenesis (FOXO1 and PEPCK) were adversely affected in diet-induced insulin-resistant rats. The convergence of chronic ER stress towards apoptosis in pancreas/liver was also indicated by increased levels of CHOP mRNA & increased activity of both JNK and Caspase-3 in rats subjected to high-fat/fructose diets. Our study exposes the experimental support in that high-fructose diet is equally detrimental in causing metabolic disorders.

  16. Synthesis of New Energetic Materials and Ionic Liquids Derived from Metronidazole

    OpenAIRE

    Romero, Miguel A.

    2016-01-01

    Simple and efficient synthetic procedures were established for the preparation of new energetic covalent compounds, salts, and protonated ionic liquids based on the readily available antimicrobial agent metronidazole. Some of these materials exhibit the desirable properties of energetic materials and energetic ionic liquids, such as low vapor pressure, low melting point, good chemical and thermal stability, and high energetic content. For each of the relevant compounds prepared, thermal stabi...

  17. EVALUATION OF FERMENTED MANGO (Mangifera indica SEED MEAL IN THE PRACTICAL DIET OF NILE TILAPIA, (Oreochromis niloticus FINGERLINGS

    Directory of Open Access Journals (Sweden)

    Samuel Olubodun Obasa

    2013-10-01

    Full Text Available This study evaluated the use of fermented mango (Mangifera indica seed meal (FMS to substitute yellow maize in the practical diet for Nile tilapia, Oreochromis niloticus fingerlings (4.76±0.32 g. Five iso-nitrogeneous (35% crude protein and approximately iso-energetic (3400 ME Kcal/kg dietsin which yellow maize was replaced by FMSat 0% (FMS0/Control diet, 25% (FMS25, 50% (FMS50, 75% (FMS75 and 100% (FMS100 levels were formulated. The fish were fed on the diets at 5% body weight for 84 days. Alkaloids were highest (2.32% among the anti-nutritional factors analyzed in FMS, while oxalate (0.84% was lowest. Potassium was highest (8.91 mg/g among the minerals, while copper was lowest (0.01 mg/g. Weight gain, specific growth rate and feed conversion ratio were similar (p>0.05 in fish fed diets FMS0 and FMS50. The fish fed diet FMS0 had the highest protein efficiency ratio (1.88. Protein digestibility decreased (p<0.05 as dietary FMS increased, while carbohydrate digestibility gave an inverse relationship. Results obtained show that FMS could replace yellow maize at 50% level without affecting growth, nutrient utilization and apparent protein digestibility in diets for Nile tilapia fingerlings.

  18. Cellular immune responses to HIV

    Science.gov (United States)

    McMichael, Andrew J.; Rowland-Jones, Sarah L.

    2001-04-01

    The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

  19. Repaglinide at a cellular level

    DEFF Research Database (Denmark)

    Krogsgaard Thomsen, M; Bokvist, K; Høy, M

    2002-01-01

    To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat...... pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas...

  20. Game of Life Cellular Automata

    CERN Document Server

    Adamatzky, Andrew

    2010-01-01

    In the late 1960s, British mathematician John Conway invented a virtual mathematical machine that operates on a two-dimensional array of square cell. Each cell takes two states, live and dead. The cells' states are updated simultaneously and in discrete time. A dead cell comes to life if it has exactly three live neighbours. A live cell remains alive if two or three of its neighbours are alive, otherwise the cell dies. Conway's Game of Life became the most programmed solitary game and the most known cellular automaton. The book brings together results of forty years of study into computational

  1. Cellular automata a parallel model

    CERN Document Server

    Mazoyer, J

    1999-01-01

    Cellular automata can be viewed both as computational models and modelling systems of real processes. This volume emphasises the first aspect. In articles written by leading researchers, sophisticated massive parallel algorithms (firing squad, life, Fischer's primes recognition) are treated. Their computational power and the specific complexity classes they determine are surveyed, while some recent results in relation to chaos from a new dynamic systems point of view are also presented. Audience: This book will be of interest to specialists of theoretical computer science and the parallelism challenge.

  2. ING proteins in cellular senescence.

    Science.gov (United States)

    Menéndez, Camino; Abad, María; Gómez-Cabello, Daniel; Moreno, Alberto; Palmero, Ignacio

    2009-05-01

    Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.

  3. Cellular Analogs of Operant Behavior.

    Science.gov (United States)

    1992-07-31

    ing of single units can be demonstrated, does such a cellular subset of neighboring pyramidal cells and interneurons as well as process contribute...excite dopamine neurons by -hyperpolarization of local interneurons . J. Neurosci. 12:483-488; 1992. Kosterlitz, H. W. Biosynthesis of morphine in the...II 197 1 1 ocation preltereite iindiis- HOIdlod VA. artdo \\M I . \\.ill I ’’’’i i R i l’)89) ( pioid mediationl lserilI1 reintoree-Cd bK amlphetcamine

  4. 5G Ultra-Dense Cellular Networks

    OpenAIRE

    Ge, Xiaohu; Tu, Song; Mao, Guoqiang; Wang, Cheng-xiang; Han, Tao

    2015-01-01

    Traditional ultra-dense wireless networks are recommended as a complement for cellular networks and are deployed in partial areas, such as hotspot and indoor scenarios. Based on the massive multiple-input multi-output (MIMO) antennas and the millimeter wavecommunication technologies, the 5G ultra-dense cellular network is proposed to deploy in overall cellular scenarios. Moreover, a distribution network architecture is presented for 5G ultra-dense cellular networks. Furthermore, the backhaul ...

  5. Advances in science and technology of modern energetic materials: an overview.

    Science.gov (United States)

    Badgujar, D M; Talawar, M B; Asthana, S N; Mahulikar, P P

    2008-03-01

    Energetic materials such as explosives, propellants and pyrotechnics are widely used for both civilian and military explosives applications. The present review focuses briefly on the synthesis aspects and some of the physico-chemical properties of energetic materials of the class: (a) aminopyridine-N-oxides, (b) energetic azides, (c) high nitrogen content energetic materials, (d) imidazoles, (e) insensitive energetic materials, (f) oxidizers, (g) nitramines, (h) nitrate esters and (i) thermally stable explosives. A brief comment is also made on the emerging nitration concepts. This paper also reviews work done on primary explosives of current and futuristic interest based on energetic co-ordination compounds. Lead-free co-ordination compounds are the candidates of tomorrow's choice in view of their additional advantage of being eco-friendly. Another desirable attribute of lead free class of energetic compounds is the presence of almost equivalent quantity of fuel and oxidizer moieties. These compounds may find wide spectrum of futuristic applications in the area of energetic materials. The over all aim of the high energy materials research community is to develop the more powerful energetic materials/explosive formulations/propellant formulations in comparison to currently known benchmark materials/compositions. Therefore, an attempt is also made to highlight the important contributions made by the various researchers in the frontier areas energetic ballistic modifiers, energetic binders and energetic plasticizers.

  6. Diabetes and diet: food choices.

    NARCIS (Netherlands)

    Niewind, A.C.

    1989-01-01

    This thesis reports on the food choices of diabetic patients. Two studies were undertaken considering the barriers these patients experience with the diabetic diet. Furthermore, the changes in food choices during the first years after the diagnosis of insulin-dependent diabetes as well as patients,

  7. Ketogenic diets and physical performance

    Directory of Open Access Journals (Sweden)

    Phinney SD

    2004-08-01

    Full Text Available Impaired physical performance is a common but not obligate result of a low carbohydrate diet. Lessons from traditional Inuit culture indicate that time for adaptation, optimized sodium and potassium nutriture, and constraint of protein to 15-25 % of daily energy expenditure allow unimpaired endurance performance despite nutritional ketosis.

  8. Thermodynamics of weight loss diets.

    Science.gov (United States)

    Fine, Eugene J; Feinman, Richard D

    2004-12-08

    BACKGROUND: It is commonly held that "a calorie is a calorie", i.e. that diets of equal caloric content will result in identical weight change independent of macronutrient composition, and appeal is frequently made to the laws of thermodynamics. We have previously shown that thermodynamics does not support such a view and that diets of different macronutrient content may be expected to induce different changes in body mass. Low carbohydrate diets in particular have claimed a "metabolic advantage" meaning more weight loss than in isocaloric diets of higher carbohydrate content. In this review, for pedagogic clarity, we reframe the theoretical discussion to directly link thermodynamic inefficiency to weight change. The problem in outline: Is metabolic advantage theoretically possible? If so, what biochemical mechanisms might plausibly explain it? Finally, what experimental evidence exists to determine whether it does or does not occur? RESULTS: Reduced thermodynamic efficiency will result in increased weight loss. The laws of thermodynamics are silent on the existence of variable thermodynamic efficiency in metabolic processes. Therefore such variability is permitted and can be related to differences in weight lost. The existence of variable efficiency and metabolic advantage is therefore an empiric question rather than a theoretical one, confirmed by many experimental isocaloric studies, pending a properly performed meta-analysis. Mechanisms are as yet unknown, but plausible mechanisms at the metabolic level are proposed. CONCLUSIONS: Variable thermodynamic efficiency due to dietary manipulation is permitted by physical laws, is supported by much experimental data, and may be reasonably explained by plausible mechanisms.

  9. PON1 and Mediterranean Diet

    Directory of Open Access Journals (Sweden)

    José M. Lou-Bonafonte

    2015-05-01

    Full Text Available The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1 has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on this enzyme. Despite the differential response of some genetic polymorphisms, the Mediterranean diet has been shown to exert a protective action on this enzyme. Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil. Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items. Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

  10. PON1 and Mediterranean Diet.

    Science.gov (United States)

    Lou-Bonafonte, José M; Gabás-Rivera, Clara; Navarro, María A; Osada, Jesús

    2015-05-27

    The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1) has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on this enzyme. Despite the differential response of some genetic polymorphisms, the Mediterranean diet has been shown to exert a protective action on this enzyme. Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil. Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items. Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

  11. [Mediterranean diet: not only food].

    Science.gov (United States)

    da Vico, Letizia; Agostini, Susanna; Brazzo, Silvia; Biffi, Barbara; Masini, Maria Luisa

    2012-09-01

    The proposal of a Mediterranean way of life is much more than advise how to eat. The Mediterranean Diet, a model of Sustainable Diet, is an example of how to combine personal choices, economic, social and cultural rights, protective of human health and the ecosystem. There is in fact fundamental interdependence between dietary requirements, nutritional recommendations, production and consumption of food. In literature studies and nutritional and epidemiological monitoring activities at national and international level have found a lack of adherence to this lifestyle, due to the spread of the economy, lifestyles of the Western type and globalization of the production and consumption. To encourage the spread of a culture and a constant practice of the Mediterranean Diet, there are some tools that are presented in this article. The Mediterranean Diet Pyramid in addition to the recommendations on the frequency and portions of food, focuses on the choice of how to cook and eat food. The "Double Food Pyramid" encourages conscious food choices based on "healthy eating and sustainability. All the nutrition professionals and dietitians in particular should be constantly striving to encourage the adoption of a sustainable and balanced nutrition.

  12. Diet History Questionnaire: Canadian Version

    Science.gov (United States)

    The Diet History Questionnaire (DHQ) and the DHQ nutrient database were modified for use in Canada through the collaborative efforts of Dr. Amy Subar and staff at the Risk Factor Monitoring and Methods Branch, and Dr. Ilona Csizmadi and colleagues in the Division of Population Health and Information at the Alberta Cancer Board in Canada.

  13. Ketogenic Diet: Effects on Growth

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2002-12-01

    Full Text Available The effects of the ketogenic diet on growth of 237 children (130 males, 107 females treated for intractable epilepsy has been evaluated in a prospective cohort study (average follow-up 308 days at the Johns Hopkins Hospital, Baltimore, MD.

  14. Ketogenic diets and physical performance

    Directory of Open Access Journals (Sweden)

    Phinney Stephen D

    2004-08-01

    Full Text Available Abstract Impaired physical performance is a common but not obligate result of a low carbohydrate diet. Lessons from traditional Inuit culture indicate that time for adaptation, optimized sodium and potassium nutriture, and constraint of protein to 15–25 % of daily energy expenditure allow unimpaired endurance performance despite nutritional ketosis.

  15. Diet and Pancreatic Cancer Prevention.

    Science.gov (United States)

    Casari, Ilaria; Falasca, Marco

    2015-11-23

    Pancreatic cancer is without any doubt the malignancy with the poorest prognosis and the lowest survival rate. This highly aggressive disease is rarely diagnosed at an early stage and difficult to treat due to its resistance to radiotherapy and chemotherapy. Therefore, there is an urgent need to clarify the causes responsible for pancreatic cancer and to identify preventive strategies to reduce its incidence in the population. Some circumstances, such as smoking habits, being overweight and diabetes, have been identified as potentially predisposing factors to pancreatic cancer, suggesting that diet might play a role. A diet low in fat and sugars, together with a healthy lifestyle, regular exercise, weight reduction and not smoking, may contribute to prevent pancreatic cancer and many other cancer types. In addition, increasing evidence suggests that some food may have chemo preventive properties. Indeed, a high dietary intake of fresh fruit and vegetables has been shown to reduce the risk of developing pancreatic cancer, and recent epidemiological studies have associated nut consumption with a protective effect against it. Therefore, diet could have an impact on the development of pancreatic cancer and further investigations are needed to assess the potential chemo preventive role of specific foods against this disease. This review summarizes the key evidence for the role of dietary habits and their effect on pancreatic cancer and focuses on possible mechanisms for the association between diet and risk of pancreatic cancer.

  16. Diet and Pancreatic Cancer Prevention

    Directory of Open Access Journals (Sweden)

    Ilaria Casari

    2015-11-01

    Full Text Available Pancreatic cancer is without any doubt the malignancy with the poorest prognosis and the lowest survival rate. This highly aggressive disease is rarely diagnosed at an early stage and difficult to treat due to its resistance to radiotherapy and chemotherapy. Therefore, there is an urgent need to clarify the causes responsible for pancreatic cancer and to identify preventive strategies to reduce its incidence in the population. Some circumstances, such as smoking habits, being overweight and diabetes, have been identified as potentially predisposing factors to pancreatic cancer, suggesting that diet might play a role. A diet low in fat and sugars, together with a healthy lifestyle, regular exercise, weight reduction and not smoking, may contribute to prevent pancreatic cancer and many other cancer types. In addition, increasing evidence suggests that some food may have chemo preventive properties. Indeed, a high dietary intake of fresh fruit and vegetables has been shown to reduce the risk of developing pancreatic cancer, and recent epidemiological studies have associated nut consumption with a protective effect against it. Therefore, diet could have an impact on the development of pancreatic cancer and further investigations are needed to assess the potential chemo preventive role of specific foods against this disease. This review summarizes the key evidence for the role of dietary habits and their effect on pancreatic cancer and focuses on possible mechanisms for the association between diet and risk of pancreatic cancer.

  17. Melanoma screening with cellular phones.

    Directory of Open Access Journals (Sweden)

    Cesare Massone

    Full Text Available BACKGROUND: Mobile teledermatology has recently been shown to be suitable for teledermatology despite limitations in image definition in preliminary studies. The unique aspect of mobile teledermatology is that this system represents a filtering or triage system, allowing a sensitive approach for the management of patients with emergent skin diseases. METHODOLOGY/PRINCIPAL FINDINGS: In this study we investigated the feasibility of teleconsultation using a new generation of cellular phones in pigmented skin lesions. 18 patients were selected consecutively in the Pigmented Skin Lesions Clinic of the Department of Dermatology, Medical University of Graz, Graz (Austria. Clinical and dermoscopic images were acquired using a Sony Ericsson with a built-in two-megapixel camera. Two teleconsultants reviewed the images on a specific web application (http://www.dermahandy.net/default.asp where images had been uploaded in JPEG format. Compared to the face-to-face diagnoses, the two teleconsultants obtained a score of correct telediagnoses of 89% and of 91.5% reporting the clinical and dermoscopic images, respectively. CONCLUSIONS/SIGNIFICANCE: The present work is the first study performing mobile teledermoscopy using cellular phones. Mobile teledermatology has the potential to become an easy applicable tool for everyone and a new approach for enhanced self-monitoring for skin cancer screening in the spirit of the eHealth program of the European Commission Information for Society and Media.

  18. Cellular functions of the microprocessor.

    Science.gov (United States)

    Macias, Sara; Cordiner, Ross A; Cáceres, Javier F

    2013-08-01

    The microprocessor is a complex comprising the RNase III enzyme Drosha and the double-stranded RNA-binding protein DGCR8 (DiGeorge syndrome critical region 8 gene) that catalyses the nuclear step of miRNA (microRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as an endonuclease. Recent global analyses of microprocessor and Dicer proteins have suggested novel functions for these components independent of their role in miRNA biogenesis. A HITS-CLIP (high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation) experiment designed to identify novel substrates of the microprocessor revealed that this complex binds and regulates a large variety of cellular RNAs. The microprocessor-mediated cleavage of several classes of RNAs not only regulates transcript levels, but also modulates alternative splicing events, independently of miRNA function. Importantly, DGCR8 can also associate with other nucleases, suggesting the existence of alternative DGCR8 complexes that may regulate the fate of a subset of cellular RNAs. The aim of the present review is to provide an overview of the diverse functional roles of the microprocessor.

  19. Cellular automata modelling of SEIRS

    Institute of Scientific and Technical Information of China (English)

    Liu Quan-Xing; Jin Zhen

    2005-01-01

    In this paper the SEIRS epidemic spread is analysed, and a two-dimensional probability cellular automata model for SEIRS is presented. Each cellular automation cell represents a part of the population that may be found in one of five states of individuals: susceptible, exposed (or latency), infected, immunized (or recovered) and death. Here studied are the effects of two cases on the epidemic spread. i.e. the effects of non-segregation and segregation on the latency and the infected of population. The conclusion is reached that the epidemic will persist in the case of non-segregation but it will decrease in the case of segregation. The proposed model can serve as a basis for the development of algorithms to simulate real epidemics based on real data. Last we find the density series of the exposed and the infected will fluctuate near a positive equilibrium point, when the constant for the immunized is less than its corresponding constant τ0. Our theoretical results are verified by numerical simulations.

  20. Feeding patterns and diet -- babies and infants

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000712.htm Feeding patterns and diet - babies and infants To use ... prevent childhood obesity Alternative names Babies and infants - feeding; Diet - age appropriate - babies and infants; Breastfeeding - babies ...

  1. High-Protein Diets: Are They Safe?

    Science.gov (United States)

    Healthy Lifestyle Nutrition and healthy eating Are high-protein diets safe for weight loss? Answers from Katherine ... L.D. For most healthy people, a high-protein diet generally isn't harmful, particularly when followed ...

  2. DASH diet to lower high blood pressure

    Science.gov (United States)

    ... ency/patientinstructions/000770.htm DASH diet to lower high blood pressure To use the sharing features on this page, ... Stop Hypertension. The DASH diet can help lower high blood pressure and cholesterol and other fats in your blood. ...

  3. Mediterranean diet and diabetes: prevention and treatment.

    Science.gov (United States)

    Georgoulis, Michael; Kontogianni, Meropi D; Yiannakouris, Nikos

    2014-04-04

    The aim of the present review is to examine current scientific knowledge on the association between the Mediterranean diet and diabetes mellitus (mostly type 2 diabetes). A definition of the Mediterranean diet and the tools widely used to evaluate adherence to this traditional diet (Mediterranean diet indices) are briefly presented. The review focuses on epidemiological data linking adherence to the Mediterranean diet with the risk of diabetes development, as well as evidence from interventional studies assessing the effect of the Mediterranean diet on diabetes control and the management of diabetes-related complications. The above mentioned data are explored on the basis of evaluating the Mediterranean diet as a whole dietary pattern, rather than focusing on the effect of its individual components. Possible protective mechanisms of the Mediterranean diet against diabetes are also briefly discussed.

  4. Nonfasting Versus Initial Fasting Ketogenic Diet

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2005-02-01

    Full Text Available A retrospective evaluation of the ketogenic diet (KD was conducted comparing efficacy and tolerability of the diet with or without initial fasting and fluid restriction and involving university centers in Seoul, Korea.

  5. Low Phosphorus Diet: Best for Kidney Disease?

    Science.gov (United States)

    ... diet: Best for kidney disease? Why is a low-phosphorus diet useful in managing kidney disease? What ... choose foods that are lower in phosphorus. Choose low-phosphorus foods The best way to limit phosphorus ...

  6. Diet affects resting, but not basal metabolic rate of normothermic Siberian hamsters acclimated to winter.

    Science.gov (United States)

    Gutowski, Jakub P; Wojciechowski, Michał S; Jefimow, Małgorzata

    2011-12-01

    We examined the effect of different dietary supplements on seasonal changes in body mass (m(b)), metabolic rate (MR) and nonshivering thermogenesis (NST) capacity in normothermic Siberian hamsters housed under semi-natural conditions. Once a week standard hamster food was supplemented with either sunflower and flax seeds, rich in polyunsaturated fatty acids (FA), or mealworms, rich in saturated and monounsaturated FA. We found that neither of these dietary supplements affected the hamsters' normal winter decrease in m(b) and fat content nor their basal MR or NST capacity. NST capacity of summer-acclimated hamsters was lower than that of winter-acclimated ones. The composition of total body fat reflected the fat composition of the dietary supplements. Resting MR below the lower critical temperature of the hamsters, and their total serum cholesterol concentration were lower in hamsters fed a diet supplemented with mealworms than in hamsters fed a diet supplemented with seeds. These results indicate that in mealworm-fed hamsters energy expenditure in the cold is lower than in animals eating a seed-supplemented diet, and that the degree of FA unsaturation of diet affects energetics of heterotherms, not only during torpor, but also during normothermy.

  7. A practical guide to fad diets.

    Science.gov (United States)

    Porcello, L A

    1984-07-01

    This discussion of fad diets may be concluded by comparing the 14 selected diets with the standards previously outlined for desirable weight reducing plans. Many of the popular diets supply large quantities of saturated fat and cholesterol, which are dietary components that have been associated with cardiovascular disease. Ketogenic diets are not appropriate for athletes because of problems with secondary dehydration and hyponatremia. Almost all of the diets are nutritionally inadequate. The rate of anticipated weight loss will vary according to the age, sex, weight, basal energy requirement, and activity level of an individual. However, it is expected that weight loss will be excessively rapid if a competitive athlete consumes a diet of less than 1000 calories per day. These hypocaloric diets cannot meet the training demands of athletes and will promote loss of lean body mass and carbohydrate stores. Many of the ketogenic diets do not restrict calories; therefore, weight loss will depend upon individual daily caloric consumption. The Cambridge Diet and starvation diets produce weight loss far in excess of that desired for an athlete in training. Long-term eating patterns to maintain weight loss are not encouraged in any of the 14 selected fad diets. In fact, most of these diets promote patterns of poor nutrition. Not one of the diets provides options or choices for dieters to use in accommodating food preference and lifestyle patterns. Some of the diets are fairly easy to comply with and others require special foods and supplements. None of the 14 diets reviewed fulfull all of the standards for a sound weight reduction diet plan.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. MIND diet slows cognitive decline with aging

    OpenAIRE

    Morris, Martha Clare; Tangney, Christy C.; Wang, Yamin; Sacks, Frank Martin; Barnes, Lisa L.; Bennett, David William; Aggarwal, Neelum T

    2015-01-01

    INTRODUCTION: The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. METHODS: We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants ...

  9. Effect of nutritional recovery with soybean flour diet on body composition, energy balance and serum leptin concentration in adult rats

    Directory of Open Access Journals (Sweden)

    Boschero Antonio C

    2009-08-01

    Full Text Available Abstract Background Malnutrition in early life is associated with obesity in adulthood and soybean products may have a beneficial effect on its prevention and treatment. This study evaluated body composition, serum leptin and energy balance in adult rats subjected to protein restriction during the intrauterine stage and lactation and recovering on a soybean flour diet. Methods Five groups of the Wistar strain of albino rats were used: CC, offspring born to and suckled by mothers fed a control diet and fed the same diet after weaning; CS, offspring born to and suckled by mothers fed a control diet and fed a soybean diet with 17% protein after weaning; LL, offspring of mothers fed a low protein diet and fed the same diet after weaning; LC, offspring of mothers fed a low protein diet, but fed a control diet after weaning; LS, offspring of mothers fed a low protein diet, but fed a soybean diet with 17% protein after weaning. Food intake, body, perirenal and retroperitoneal adipose tissue were measured in grams. Leptin was quantified using the Enzyme Linked Immuno Sorbent Assay (ELISA and insulin by radioimmunoassay (RIA. Carcass composition was determined by chemical methods and energy expenditure was calculated by the difference between energy intake and carcass energy gain. Data were tested by analysis of variance (ANOVA. Results The LC and LS groups had higher energetic intake concerning body weight, lower energy expenditure, proportion of fat carcass and fat pads than CC and CS groups. The LS group showed reduced body weight gain and lower energy efficiency, which was reflected in less energy gain as protein and the proportion of carcass protein, and lower energy gain as lipid than in the LC groups, although both groups had eaten the same amount of diet and showed equal energy expenditure. Serum leptin did not differ among groups and was unrelated to food or energy intake and energy expenditure. Serum insulin was higher in the LS than in the LC

  10. Health Effects of the New Nordic Diet

    DEFF Research Database (Denmark)

    Poulsen, Sanne Kellebjerg

    The health effects of the New Nordic Diet (NND) are investigated in a six month randomized controlled intervention, in which the NND was compared to the average Danish diet (ADD) among 181 adult participants. Foods were handed out free of charge from a study shop according to the ad libitum...... has a potential as a healthy and highly satisfying diet for the general population....

  11. Evaluation of nanoparticles in the performance of energetic materials

    Directory of Open Access Journals (Sweden)

    José Atílio Fritz Fidel Rocco

    2010-04-01

    Full Text Available The addition of nanosized metal particles in propulsion systems such as solid and liquid propellants, hybrid propellant and ramjet motors has recently became a major focus of research. Significant increases in the burning velocity and in the specific impulse are some of the advantages of using nano-scale energetic materials in many different types of propulsion systems. Aluminum has been largely employed as a metallic additive in energetic materials, also in a recently new propulsion system (aluminum/ice propulsion, “Alice”, and some studies show that the advantages of using nanosized aluminum instead of microsized aluminum are facilitating the ignition of the systems and allowing better incorporation of the components in the formulations and improving its homogeneity. Some of the combustion processes that require high pressures and even higher temperatures can occur in moderate conditions due to the increase of the surface area of the reactants, in this case, the metallic additive.

  12. Ultrafast laser diagnostics to investigate initiation fundamentals in energetic materials.

    Energy Technology Data Exchange (ETDEWEB)

    Farrow, Darcie; Jilek, Brook Anton; Kohl, Ian Thomas; Kearney, Sean Patrick

    2013-08-01

    We present the results of a two year early career LDRD project, which has focused on the development of ultrafast diagnostics to measure temperature, pressure and chemical change during the shock initiation of energetic materials. We compare two single-shot versions of femtosecond rotational CARS to measure nitrogen temperature: chirped-probe-pulse and ps/fs hybrid CARS thermometry. The applicability of measurements to the combustion of energetic materials will be discussed. We have also demonstrated laser shock and particle velocity measurements in thin film explosives using stretched femtosecond laser pulses. We will discuss preliminary results from Al and PETN thin films. Agreement between our results and previous work will be discussed.

  13. Mechanisms of Stochastic Diffusion of Energetic Ions in Spherical Tori

    Energy Technology Data Exchange (ETDEWEB)

    Ya.I. Kolesnichenko; R.B. White; Yu.V. Yakovenko

    2001-01-18

    Stochastic diffusion of the energetic ions in spherical tori is considered. The following issues are addressed: (I) Goldston-White-Boozer diffusion in a rippled field; (ii) cyclotron-resonance-induced diffusion caused by the ripple; (iii) effects of non-conservation of the magnetic moment in an axisymmetric field. It is found that the stochastic diffusion in spherical tori with a weak magnetic field has a number of peculiarities in comparison with conventional tokamaks; in particular, it is characterized by an increased role of mechanisms associated with non-conservation of the particle magnetic moment. It is concluded that in current experiments on National Spherical Torus eXperiment (NSTX) the stochastic diffusion does not have a considerable influence on the confinement of energetic ions.

  14. Monte Carlo simulations of the Galileo energetic particle detector

    CERN Document Server

    Jun, I; Garrett, H B; McEntire, R W

    2002-01-01

    Monte Carlo radiation transport studies have been performed for the Galileo spacecraft energetic particle detector (EPD) in order to study its response to energetic electrons and protons. Three-dimensional Monte Carlo radiation transport codes, MCNP version 4B (for electrons) and MCNPX version 2.2.3 (for protons), were used throughout the study. The results are presented in the form of 'geometric factors' for the high-energy channels studied in this paper: B1, DC2, and DC3 for electrons and B0, DC0, and DC1 for protons. The geometric factor is the energy-dependent detector response function that relates the incident particle fluxes to instrument count rates. The trend of actual data measured by the EPD was successfully reproduced using the geometric factors obtained in this study.

  15. Heliospheric Magnetic Fields, Energetic Particles, and the Solar Cycle

    Indian Academy of Sciences (India)

    Peter Kiraly

    2000-09-01

    The heliosphere is the region filled with magnetized plasma of mainly solar origin. It extends from the solar corona to well beyond the planets, and is separated from the interstellar medium by the heliopause. The latter is embedded in a complex and still unexplored boundary region. The characteristics of heliospheric plasma, fields, and energetic particles depend on highly variable internal boundary conditions, and also on quasi-stationary external ones. Both galactic cosmic rays and energetic particles of solar and heliospheric origin are subject to intensity variations over individual solar cycles and also from cycle to cycle. Particle propagation is controlled by spatially and temporally varying interplanetary magnetic fields, frozen into the solar wind. An overview is presented of the main heliospheric components and processes, and also of the relevant missions and data sets. Particular attention is given to flux variations over the last few solar cycles, and to extrapolated effects on the terrestrial environment.

  16. Energetic particles as probes of solar wind disturbances

    Energy Technology Data Exchange (ETDEWEB)

    Cane, H.V.; Richardson, I.G.; Wibberenz, G.

    1995-06-01

    The authors have investigated the response of particles, in the energy range approximately 1-5000 MeV, to interplanetary shocks and coronal ejecta. Shocks can accelerate particles or cause decreases in particle densities. Ejecta cause decreases. Thus particle observations can provide information about solar wind disturbances. Of particular interest is that the boundaries of ejecta can often be more readily identified from approximately l GeV particle decrease observations than from most other phenomena associated with ejecta. The authors will discuss the properties of less energetic shocks and ejecta and compare them with those of the more energetic events which are normally discussed in the context of Forbush decreases, large proton events, etc. They use data from both Helios spacecraft and IMP 8 which allows some spatial variations to be studied.

  17. Energetics and efficiency of a molecular motor model

    DEFF Research Database (Denmark)

    C. Fogedby, Hans; Svane, Axel

    2013-01-01

    The energetics and efficiency of a linear molecular motor model proposed by Mogilner et al. (Phys. Lett. 237, 297 (1998)) is analyzed from an analytical point of view. The model which is based on protein friction with a track is described by coupled Langevin equations for the motion in combination...... with coupled master equations for the ATP hydrolysis. Here the energetics and efficiency of the motor is addressed using a many body scheme with focus on the efficiency at maximum power (EMP). It is found that the EMP is reduced from about 10 pct in a heuristic description of the motor to about 1 per mille...... when incorporating the full motor dynamics, owing to the strong dissipation associated with the motor action....

  18. Fe-rich solar energetic particle events during solar minimum

    Science.gov (United States)

    Mazur, J. E.; Mason, G. M.; von Rosenvinge, T. T.

    During the first 10 months of WIND observations, we have detected several time periods with energetic particle abundances that are characteristic of impulsive flares: enrichments in the ³He isotope, and in heavy ions compared to the corona. Using the Supra-Thermal through Energetic Particle sensor on WIND, we find that at ∼100 keV/nucleon these events typically arrive in sequences of multiple events when the spacecraft is magnetically connected to an active region at western solar longitudes, preceding the arrival of a high speed solar wind stream. During recurrent high speed solar wind streams with their associated flux enhancements Fe-rich events are seldom seen: almost all of the events occur on days with solar wind speeds ISEE-3.

  19. Post-equinox periodicities in Saturn's energetic electrons

    Science.gov (United States)

    Carbary, J. F.; Mitchell, D. G.; Krimigis, S. M.; Krupp, N.

    2011-12-01

    Since Saturn's vernal equinox in August 2009 (day 223), energetic electrons (110-365 keV) have exhibited a variety of periodic and aperiodic behavior within a spectral window of 5-15 hours. From late 2009 through the end of 2010, when the observed at dusk, a single period near 10.7 hours dominated the Lomb spectra of these particles. Near the end of 2010, however, the energetic electrons displayed multiple periods, with the strongest at 10.65 hours. The periodicity observed after equinox has a mean value of 10.69 ± 0.06 hours and agreed closely with that of Saturn kilometric radio (south) emissions. By early 2011, when the observer had moved to the dayside, the periodicities abruptly disappeared and the Lomb spectra show no periodicity. This behavior may suggest changes in Saturn's ionosphere as a result of seasonal change, or may alternately imply a local time dependence of periodicity caused by magnetodisk thickness asymmetry.

  20. Gyroresonant interaction of energetic trapped electrons and protons

    Science.gov (United States)

    Villalon, Elena; Silevitch, Michael B.; Burke, William J.; Rothwell, Paul L.

    The present consideration of the theory of gyroresonant interactions of energetic trapped electrons and protons with ducted EM cyclotron waves in the earth's radiation zones derives a set of equations, based on the Fokker-Planck theory of pitch-angle diffusion, which describe the temporal evolution of the number of particles in the flux tube, and the energy density of waves, for (1) the interaction of Alfven waves with protons and (2) that of whistler waves with electrons. Attention is given to the reflection of the waves in the ionosphere. To dump the energetic particles from the radiation belts efficiently, the reflection coefficient must be close to unity to facilitate the growth of wave amplitudes; precipitating particle fluxes may then act as a positive feedback to raise the height-integrated conductivity of the ionosphere. This conductivity in turn enhances wave reflection.

  1. Cholesterol-induced protein sorting: an analysis of energetic feasibility

    DEFF Research Database (Denmark)

    Lundbaek, J A; Andersen, O S; Werge, T;

    2003-01-01

    transmembrane domain (TMD). M. S. Bretscher and S. Munro (SCIENCE: 261:1280-1281, 1993) therefore proposed a physical sorting mechanism based on the hydrophobic match between the proteins' TMD and the bilayer thickness, in which cholesterol would regulate protein sorting by increasing the lipid bilayer...... thickness. In this model, Golgi proteins with short TMDs would be excluded from cholesterol-enriched domains (lipid rafts) that are incorporated into transport vesicles destined for the plasma membrane. Although attractive, this model remains unproven. We therefore evaluated the energetic feasibility...... thickness per se, however, have only a modest effect on sorting; the major effect arises because cholesterol changes also the bilayer material properties, which augments the energetic penalty for incorporating short TMDs into cholesterol-enriched domains. We conclude that cholesterol-induced changes...

  2. Energetic and Ecological Analysis of Energy Saving and Passive Houses

    Science.gov (United States)

    Sanytsky, Myroslav; Sekret, Robert; Wojcikiewicz, Mariusz

    2012-06-01

    In this paper results of influence of building-installation system parameters on value of energetic coefficients were calculated. Three types of buildings (standard, energy saving and low energy) with heating surface of 100, 150 i 200 m2 were used. The above types of buildings differ on thermal barrier and heating system efficiency. The influence of the gravity and mechanical ventilation systems on the final heat energy of different kinds of houses was shown. Parameters of the certificate for energy characteristics of building were used. Mathematics models of influence of thermal barrier parameters and heating surface on the value of energy characteristics, namely final energy EF, primary energy EP and useful energy EU were established. Influence of such parameters as heating energy factors, ventilation system and energy sources on the energy efficiency improvement of buildings was analyzed. The building environmental assessment system was proposed on the base of energetic and ecological analysis of houses.

  3. Assessment of HCDA energetics in the CRBRP heterogeneous reactor core

    Energy Technology Data Exchange (ETDEWEB)

    Rhow, S K; Switick, D M; McElroy, J L; Joe, B W; Elawar, Z J

    1981-03-27

    The results of hypothetical core disruptive event analyses for the CRBRP heterogeneous reactor core are reported. The analytical results cover a large number of parametric cases including variations in design parameters and phenomenological assumptions. Reactor core configurations at the beginning of cycle one and end of cycle four are evaluated. The energetic consequences are evaluated based upon both fuel expansion thermodynamic work potential and a relative probability assignment. It is concluded that the structural loads, which result from 101 megajoules of available expansion work at sodium slug impact on the reactor closure head (equivalent to 661 megajoules of fuel expansion work to one atmosphere), is an adequate energetic consequence envelope for use in specifying the Structural Margins Beyond the Design Basis.

  4. Feasibility and energetic evaluation of air stripping for bioethanol production.

    Science.gov (United States)

    Schläfle, Sandra; Senn, Thomas; Gschwind, Peter; Kohlus, Reinhard

    2017-05-01

    Stripping of mashes with air as stripping gas and low ethanol contents between 3 and 5wt% was investigated in terms of its suitability for continuous bioethanol production. Experiments in a Blenke cascade system were carried out and the results were compared with values obtained from theoretical vapour-liquid-equilibrium calculations. The whole stripping process was energetically evaluated by a simulation in ChemCAD and compared to conventional distillation. Therefore several parameters such as temperature, air volume flow and initial ethanol load of the mash were varied. Air stripping was found to be a suitable separation method for bioethanol from mashes with low concentrations. However, energetic aspects have to be considered, when developing a new process.

  5. Theory of ring sweeping of energetic particles. [in Neptune environment

    Science.gov (United States)

    Paranicas, C. P.; Cheng, A. F.

    1991-01-01

    Because the effective 'area' of the Neptunian rings is larger than that of the inner moons, the sweeping of energetic particles by the rings is perhaps the dominant process for particle loss in the magnetosphere within 5 R(N). In this paper, a theory for calculating the absorption probability of energetic charged particles by the rings is described. The effects of a large tilt and an offset between the planet and dipole centers are included. It is found that the probability of absorption for protons is so high that the sweeping lifetime is only a few times the gradient-curvature drift period. For electrons, the sweeping lifetime is even less. The pitch angle dependence for sweeping manifests itself strongly only at large equatorial pitch angles. Lower-energy particles have higher absorption rates by the rings.

  6. Food environments select microorganisms based on selfish energetic behavior

    Directory of Open Access Journals (Sweden)

    Diego eMora

    2013-11-01

    Full Text Available Nutrient richness, and specifically the abundance of mono- and disaccharides that characterize several food matrixes, such as milk and grape juice, has allowed the speciation of lactic acid bacteria and yeasts with a high fermentation capacity instead of energetically favorable respiratory metabolism. In these environmental contexts, rapid sugar consumption and lactic acid or ethanol production, accumulation and tolerance, together with the ability to propagate in the absence of oxygen, are several of the ‘winning’ traits that have apparently evolved and become specialized to perfection in these fermenting microorganisms. Here, we summarize and discuss the evolutionary context that has driven energetic metabolism in food-associated microorganisms, using the dairy species Lactococcus lactis and Streptococcus thermophilus among prokaryotes and the bakers’ yeast Saccharomyces cerevisiae among eukaryotes as model organisms.

  7. Food environments select microorganisms based on selfish energetic behavior.

    Science.gov (United States)

    Mora, Diego; Arioli, Stefania; Compagno, Concetta

    2013-01-01

    Nutrient richness, and specifically the abundance of mono- and disaccharides that characterize several food matrixes, such as milk and grape juice, has allowed the speciation of lactic acid bacteria and yeasts with a high fermentation capacity instead of energetically favorable respiratory metabolism. In these environmental contexts, rapid sugar consumption and lactic acid or ethanol production, accumulation, and tolerance, together with the ability to propagate in the absence of oxygen, are several of the "winning" traits that have apparently evolved and become specialized to perfection in these fermenting microorganisms. Here, we summarize and discuss the evolutionary context that has driven energetic metabolism in food-associated microorganisms, using the dairy species Lactococcus lactis and Streptococcus thermophilus among prokaryotes and the bakers' yeast Saccharomyces cerevisiae among eukaryotes as model organisms.

  8. Proteomic characterization of cellular and molecular processes that enable the Nanoarchaeum equitans--Ignicoccus hospitalis relationship.

    Directory of Open Access Journals (Sweden)

    Richard J Giannone

    Full Text Available Nanoarchaeum equitans, the only cultured representative of the Nanoarchaeota, is dependent on direct physical contact with its host, the hyperthermophile Ignicoccus hospitalis. The molecular mechanisms that enable this relationship are unknown. Using whole-cell proteomics, differences in the relative abundance of >75% of predicted protein-coding genes from both Archaea were measured to identify the specific response of I. hospitalis to the presence of N. equitans on its surface. A purified N. equitans sample was also analyzed for evidence of interspecies protein transfer. The depth of cellular proteome coverage achieved here is amongst the highest reported for any organism. Based on changes in the proteome under the specific conditions of this study, I. hospitalis reacts to N. equitans by curtailing genetic information processing (replication, transcription in lieu of intensifying its energetic, protein processing and cellular membrane functions. We found no evidence of significant Ignicoccus biosynthetic enzymes being transported to N. equitans. These results suggest that, under laboratory conditions, N. equitans diverts some of its host's metabolism and cell cycle control to compensate for its own metabolic shortcomings, thus appearing to be entirely dependent on small, transferable metabolites and energetic precursors from I. hospitalis.

  9. Proteomic characterization of cellular and molecular processes that enable the Nanoarchaeum equitans--Ignicoccus hospitalis relationship.

    Science.gov (United States)

    Giannone, Richard J; Huber, Harald; Karpinets, Tatiana; Heimerl, Thomas; Küper, Ulf; Rachel, Reinhard; Keller, Martin; Hettich, Robert L; Podar, Mircea

    2011-01-01

    Nanoarchaeum equitans, the only cultured representative of the Nanoarchaeota, is dependent on direct physical contact with its host, the hyperthermophile Ignicoccus hospitalis. The molecular mechanisms that enable this relationship are unknown. Using whole-cell proteomics, differences in the relative abundance of >75% of predicted protein-coding genes from both Archaea were measured to identify the specific response of I. hospitalis to the presence of N. equitans on its surface. A purified N. equitans sample was also analyzed for evidence of interspecies protein transfer. The depth of cellular proteome coverage achieved here is amongst the highest reported for any organism. Based on changes in the proteome under the specific conditions of this study, I. hospitalis reacts to N. equitans by curtailing genetic information processing (replication, transcription) in lieu of intensifying its energetic, protein processing and cellular membrane functions. We found no evidence of significant Ignicoccus biosynthetic enzymes being transported to N. equitans. These results suggest that, under laboratory conditions, N. equitans diverts some of its host's metabolism and cell cycle control to compensate for its own metabolic shortcomings, thus appearing to be entirely dependent on small, transferable metabolites and energetic precursors from I. hospitalis.

  10. Metabolic profile in growing buffalo heifers fed diet with different energy content

    Directory of Open Access Journals (Sweden)

    B. Gasparrini

    2010-02-01

    Full Text Available Aim of this study was to verify the relation among the mediators and indicators of nutritional status like insulin, glucagon, urea, cholesterol, triglycerides and total proteins in growing buffalo heifers, fed diets with different energy density. 12 Murrah heifers were randomly allocated into two dietary treatments (High, Group H; Low, Group L that differed in energetic levels (Group H: 5.8 UFL/d; Group L: 3.6 UFL/d. Every 30 days, for a total of five times, blood samples were collected at 08.00 h, before feeding, from the jugular vein in vacutainer tubes and analysed to determine metabolic profile. Data on haematic constants were analysed by ANOVA for repeated measures with treatment as the main factor. Low energy availability and low NSC reduced the glucose and insulin and increased glucagone and urea blood levels. The increase of NSC in the diet of group H during the experiment may caused a reduction of the fibre digestibility after the period of adaptation of the rumen microflora and, as a paradox effect, suffered for an energetic lack with a subsequent activation of lipolysis and mobilization of their body reserves. Liver and muscular synthesis increase in group with a high energy availability.

  11. Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content

    DEFF Research Database (Denmark)

    Petersen, M; Taylor, M A; Saris, W H M

    2006-01-01

    and 40% in the high-fat group (mean difference: 16 (95% confidence interval (CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group (mean difference: 0.3 (95% CI -0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% (n = 70) in the high...

  12. Measurement of energetic single-photon production at LEP

    Science.gov (United States)

    Acciarri, M.; Adam, A.; Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.; Alcaraz, J.; Aloisio, A.; Alverson, G.; Alviggi, M. G.; Ambrosi, G.; An, Q.; Anderhub, H.; Anderson, A. L.; Andreev, V. P.; Angelescu, T.; Antonov, L.; Antreasyan, D.; Alkhazov, G.; Arce, P.; Arefiev, A.; Azemoon, T.; Aziz, T.; Baba, P. V. K. S.; Bagnaia, P.; Bakken, J. A.; Baksay, L.; Ball, R. C.; Banerjee, S.; Banicz, K.; Barillère, R.; Barone, L.; Baschirotto, A.; Basile, M.; Battiston, R.; Bay, A.; Becattini, F.; Becker, U.; Behner, F.; Bencze, Gy. L.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B. L.; Biasini, M.; Biland, A.; Bilei, G. M.; Bizzarri, R.; Blaising, J. J.; Bobbink, G. J.; Bock, R.; Böhm, A.; Borgia, B.; Boucham, A.; Bourilkov, D.; Bourquin, M.; Boutigny, D.; Bouwens, B.; Brambilla, E.; Branson, J. G.; Brigljevic, V.; Brock, I. C.; Brooks, M.; Bujak, A.; Burger, J. D.; Burger, W. J.; Burgos, C.; Busenitz, J.; Buytenhuijs, A.; Bykov, A.; Cai, X. D.; Capell, M.; Cara Romeo, G.; Caria, M.; Carlino, G.; Cartacci, A. M.; Casaus, J.; Castello, R.; Cavallo, N.; Cerrada, M.; Cesaroni, F.; Chamizo, M.; Chang, Y. H.; Chaturvedi, U. K.; Chemarin, M.; Chen, A.; Chen, C.; Chen, G.; Chen, G. M.; Chen, H. F.; Chen, H. S.; Chen, M.; Chiefari, G.; Chien, C. Y.; Choi, M. T.; Chung, S.; Cifarelli, L.; Cindolo, F.; Civinini, C.; Clare, I.; Clare, R.; Coan, T. E.; Cohn, H. O.; Coignet, G.; Colino, N.; Commichau, V.; Costantini, S.; Cotorobai, F.; de la Cruz, B.; Cui, X. T.; Cui, X. Y.; Dai, T. S.; D'Alessandro, R.; de Asmundis, R.; Degré, A.; Deiters, K.; Dénes, E.; Denes, P.; DeNotaristefani, F.; DiBitonto, D.; Diemoz, M.; Dimitrov, H. R.; Dionisi, C.; Dittmar, M.; Dorne, I.; Dova, M. T.; Drago, E.; Duchesneau, D.; Duhem, F.; Duinker, P.; Duran, I.; Dutta, S.; Easo, S.; El Mamouni, H.; Engler, A.; Eppling, F. J.; Erné, F. C.; Extermann, P.; Fabbretti, R.; Fabre, M.; Falciano, S.; Favara, A.; Fay, J.; Felcini, M.; Ferguson, T.; Fernandez, D.; Fernandez, G.; Ferroni, F.; Fesefeldt, H.; Fiandrini, E.; Field, J. H.; Filthaut, F.; Fisher, P. H.; Forconi, G.; Fredj, L.; Freudenreich, K.; Gailloud, M.; Galaktionov, Yu.; Gallo, E.; Ganguli, S. N.; Garcia-Abia, P.; Gau, S. S.; Gentile, S.; Gerald, J.; Gheordanescu, N.; Giagu, S.; Goldfarb, S.; Goldstein, J.; Gong, Z. F.; Gonzalez, E.; Gougas, A.; Goujon, D.; Gratta, G.; Gruenewald, M. W.; Gu, C.; Guanziroli, M.; Gupta, V. K.; Gurtu, A.; Gustafson, H. R.; Gutay, L. J.; Hartmann, B.; Hasan, A.; Hauschildt, D.; He, J. T.; Hebbeker, T.; Hebert, M.; Hervé, A.; Hilgers, K.; Hofer, H.; Hoorani, H.; Hou, S. R.; Hu, G.; Ille, B.; Ilyas, M. M.; Innocente, V.; Janssen, H.; Jin, B. N.; Jones, L. W.; de Jong, P.; Josa-Mutuberria, I.; Kasser, A.; Khan, R. A.; Kamyshkov, Yu.; Kapinos, P.; Kapustinsky, J. S.; Karyotakis, Y.; Kaur, M.; Khokhar, S.; Kienzle-Focacci, M. N.; Kim, D.; Kim, J. K.; Kim, S. C.; Kim, Y. G.; Kinnison, W. W.; Kirkby, A.; Kirkby, D.; Kirkby, J.; Kirsch, S.; Kittel, W.; Klimentov, A.; König, A. C.; Koffeman, E.; Kornadt, O.; Koutsenko, V.; Koulbardis, A.; Kraemer, R. W.; Kramer, T.; Krastev, V. R.; Krenz, W.; Kuijten, H.; Kunin, A.; Ladron de Guevara, P.; Landi, G.; Lanzano, S.; Laurikainen, P.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, D. M.; Lee, J. S.; Lee, K. Y.; Leedom, I.; Leggett, C.; Le Goff, J. M.; Leiste, R.; Lenti, M.; Leonardi, E.; Levtchenko, P.; Li, C.; Lieb, E.; Lin, W. T.; Linde, F. L.; Lindemann, B.; Lista, L.; Liu, Y.; Lohmann, W.; Longo, E.; Lu, W.; Lu, Y. S.; Lubbers, J. M.; Lübelsmeyer, K.; Luci, C.; Luckey, D.; Ludovici, L.; Luminari, L.; Lustermann, W.; Ma, W. G.; MacDermott, M.; Maity, M.; Malgeri, L.; Malik, R.; Malinin, A.; Maña, C.; Mangla, S.; Maolinbay, M.; Marchesini, P.; Marin, A.; Martin, J. P.; Marzano, F.; Massaro, G. G. G.; Mazumdar, K.; McMahon, T.; McNally, D.; Mele, S.; Merk, M.; Merola, L.; Meschini, M.; Metzger, W. J.; Mi, Y.; Mihul, A.; Mills, G. B.; Mir, Y.; Mirabelli, G.; Mnich, J.; Möller, M.; Monaco, V.; Monteleoni, B.; Morand, R.; Morganti, S.; Moulai, N. E.; Mount, R.; Müller, S.; Nagy, E.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Niaz, M. A.; Nippe, A.; Nowak, H.; Organtini, G.; Ostonen, R.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Pascale, G.; Passaleva, G.; Patricelli, S.; Paul, T.; Pauluzzi, M.; Paus, C.; Pauss, F.; Pei, Y. J.; Pensotti, S.; Perret-Gallix, D.; Pevsner, A.; Piccolo, D.; Pieri, M.; Pinto, J. C.; Piroué, P. A.; Pistolesi, E.; Plasil, F.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Produit, N.; Qian, J. M.; Qureshi, K. N.; Raghavan, R.; Rahal-Callot, G.; Rancoita, P. G.; Rattaggi, M.; Raven, G.; Razis, P.; Read, K.; Redaelli, M.; Ren, D.; Ren, Z.; Rescigno, M.; Reucroft, S.; Ricker, A.; Riemann, S.; Riemers, B. C.; Riles, K.; Rind, O.; Rizvi, H. A.; Ro, S.; Robohm, A.; Rodriguez, F. J.; Roe, B. P.; Röhner, M.; Röhner, S.; Romero, L.; Rosier-Lees, S.; Rosmalen, R.; Rosselet, Ph.; van Rossum, W.; Roth, S.; Rubbia, A.; Rubio, J. A.; Rykaczewski, H.; Salicio, J.; Salicio, J. M.; Sanchez, E.; Sanders, G. S.; Santocchia, A.; Sarakinos, M. E.; Sarkar, S.; Sartorelli, G.; Sassowsky, M.; Sauvage, G.; Schäfer, C.; Schegelsky, V.; Schmitz, D.; Schmitz, P.; Schneegans, M.; Scholz, N.; Schopper, H.; Schotanus, D. J.; Shotkin, S.; Schreiber, H. J.; Shukla, J.; Schulte, R.; Schultze, K.; Schwenke, J.; Schwering, G.; Sciacca, C.; Sehgal, R.; Seiler, P. G.; Sens, J. C.; Servoli, L.; Sheer, I.; Shevchenko, S.; Shi, X. R.; Shumilov, E.; Shoutko, V.; Son, D.; Sopczak, A.; Soulimov, V.; Spartiotis, C.; Spickermann, T.; Spillantini, P.; Steuer, M.; Stickland, D. P.; Sticozzi, F.; Stone, H.; Strauch, K.; Sudhakar, K.; Sultanov, G.; Sun, L. Z.; Susinno, G. F.; Suter, H.; Swain, J. D.; Syed, A. A.; Tang, X. W.; Taylor, L.; Timellini, R.; Ting, Samuel C. C.; Ting, S. M.; Toker, O.; Tonutti, M.; Tonwar, S. C.; Tóth, J.; Trowitzsch, G.; Tsaregorodtsev, A.; Tsipolitis, G.; Tully, C.; Ulbricht, J.; Urbán, L.; Uwer, U.; Valente, E.; Van de Walle, R. T.; Vetlitsky, I.; Viertel, G.; Vikas, P.; Vikas, U.; Vivargent, M.; Vogel, H.; Vogt, H.; Vorobiev, I.; Vorobyov, A. A.; Vorobyov, An. A.; Vuilleumier, L.; Wadhwa, M.; Wallraff, W.; Wang, J. C.; Wang, X. L.; Wang, Y. F.; Wang, Z. M.; Weber, A.; Weill, R.; Willmott, C.; Wittgenstein, F.; Wright, D.; Wu, S. X.; Wynhoff, S.; Xu, Z. Z.; Yang, B. Z.; Yang, C. G.; Yang, G.; Yao, X. Y.; Ye, C. H.; Ye, J. B.; Ye, Q.; Yeh, S. C.; You, J. M.; Yunus, N.; Yzerman, M.; Zaccardelli, C.; Zemp, P.; Zeng, M.; Zeng, Y.; Zhang, D. H.; Zhang, Z. P.; Zhou, B.; Zhou, G. J.; Zhou, J. F.; Zhu, R. Y.; Zichichi, A.; van der Zwaan, B. C. C.

    1995-02-01

    We describe the sample of energetic single-photon events ( Eγ > 15 GeV) collected by L3 in the 1991-1993 LEP runs. The event distributions agree with expectations from the Standard Model. The data are used to constrain the ZZ γ coupling and to set an upper limit of 4.1 × 10 -6, μB (90% C.L.) on the the magnetic moment of the τ neutrino.

  13. Energetic Light Fragment Production Capability in MCNP6

    CERN Document Server

    Kerby, Leslie M; Gudima, Konstantin K; Sierk, Arnold J; Bull, Jeffrey S; James, Michael R

    2016-01-01

    The goal of this research is to enable MCNP6 to produce high-energy light fragments. These energetic light fragments may be emitted by our models through three processes: Fermi breakup, preequilibrium, and coalescence. We explore the emission of light fragments through each of these mechanisms and demonstrate an improved agreement with experimental data achieved by extending precompound models to include emission of fragments heavier than $^4$He.

  14. Electronic State Decomposition of Energetic Materials and Model Systems

    Science.gov (United States)

    2010-11-17

    tetrazine1,4-dioxde ( DATO ), is investigated. Although these molecules are based on N -oxides of a tetrazine aromatic heterocyclic ring, their...nitramines, furazan, tetrazines, tetrazine-N oxides, terazoles, PETN, RDX,HMX,CL-20,DAATO,ACTO, DATO ,conical intersections Elliot R Bernstein Colorado State...Tetrazine-N-Oxide Based High Nitrogen Content Energetic Materials from Excited Electronic States," J. Chem. Phys. 131, 194304 (2009). A

  15. Global Energetics of Thirty-Eight Large Solar Eruptive Events

    Science.gov (United States)

    2012-10-17

    using Hα and EUV images with MDI LOS magnetograms (Bobra et al. 2008), and (3) MHD modeling (Metcalf et al. 1995; Jiao et al. 1997) and non-potential...providing useful constraints for modelers of the energy release process(es) involved. This paper grew out of the energetics working group at the meeting...and Climate Experiment (SORCE). For weaker events, or where total irradiance measurements are not available, the Flare Irradiance Spectral Model (FISM

  16. MHD MODES DESTABILIZED BY ENERGETIC IONS ON LHD

    Energy Technology Data Exchange (ETDEWEB)

    Toi, K. [National Institute for Fusion Science, Toki, Japan; Isobe, M. [National Institute for Fusion Science, Toki, Japan; Spong, Donald A [ORNL

    2010-01-01

    nergetic ion driven magnetohydrodynamic instabilities such as Alfven eigenmodes (AEs), energetic particle modes (EPMs), and their impacts on energetic ion confinement are being studied on the Large Helical Device (LHD). The magnetic configuration of this device is three dimensional and has negative magnetic shear over a whole radial region in the low-beta regime. Two types of toroidicity-induced Alfven eigenmodes (TAEs) are typically observed in LHD plasmas that are heated by tangential neutral beam injection: One is localized in the plasma core region near a central TAE gap and the other is a global TAE having a radially extended eigenfunction. Core-localized TAEs with even and odd radial mode parities are often observed. The global TAE is usually observed in medium- to high-beta plasmas where broad regions with low magnetic shear are present. Helicity-induced Alfven eigenmodes (HAEs), which exist in gaps unique to three-dimensional plasmas that have both toroidal and poloidal mode couplings, were detected for the first time. Recently, reversed magnetic shear Alfven eigenmodes (RSAEs) having characteristic frequency sweeping were discovered in reversed magnetic shear (RS) plasmas produced by intense counter-neutral beam current drive. In the RS plasma, the geodesic acoustic mode (GAM) excited by energetic ions, which is a global-type mode different from localized GAM excited by drift waves, was also detected for the first time in a helical plasma. Nonlinear couplings between RSAE and GAM modes and also between two TAEs were observed. Bursts of TAEs and EPMs often enhance radial transport and loss of energetic ions at low toroidal magnetic field (<0.75 T).

  17. Cesium pentazolate: A new nitrogen-rich energetic material

    Science.gov (United States)

    Steele, Brad A.; Stavrous, Elissaios; Prakapenka, Vitali B.; Radousky, Harry; Zaug, Joseph; Crowhurst, Jonathan C.; Oleynik, Ivan I.

    2017-01-01

    We report theoretical and experimental evidence for a new class of high-nitrogen content energetic material compounds consisting of molecular pentazoles, which are stabilized in the crystal phase upon introduction of elemental cesium. First-principles structural predictions show that the material with composition CsN5 is thermodynamically stable above 15 GPa. Indexing of the measured X-ray diffraction spectra indicate the synthesis of this material at 60 GPa as well its stability upon decompression down to 24 GPa.

  18. Energetic particles in laboratory, space and astrophysical plasmas

    Science.gov (United States)

    McClements, K. G.; Turnyanskiy, M. R.

    2017-01-01

    Some recent studies of energetic particles in laboratory, space and astrophysical plasmas are discussed, and a number of common themes identified. Such comparative studies can elucidate the underlying physical processes. For example microwave bursts observed during edge localised modes (ELMs) in the mega amp spherical tokamak (MAST) can be attributed to energetic electrons accelerated by parallel electric fields associated with the ELMs. The very large numbers of electrons known to be accelerated in solar flares must also arise from parallel electric fields, and the demonstration of energetic electron production during ELMs suggests close links at the kinetic level between ELMs and flares. Energetic particle studies in solar flares have focussed largely on electrons rather than ions, since bremsstrahlung from deka-keV electrons provides the best available explanation of flare hard x-ray emission. However ion acceleration (but not electron acceleration) has been observed during merging startup of plasmas in MAST with dimensionless parameters similar to those of the solar corona during flares. Recent measurements in the Earth’s radiation belts demonstrate clearly a direct link between ion cyclotron emission (ICE) and fast particle population inversion, supporting the hypothesis that ICE in tokamaks is driven by fast particle distributions of this type. Shear Alfvén waves in plasmas with beta less than the electron to ion mass ratio have a parallel electric field that, in the solar corona, could accelerate electrons to hard x-ray-emitting energies; an extension of this calculation to plasmas with Alfvén speed arbitrarily close to the speed of light suggests that the mechanism could play a role in the production of cosmic ray electrons.

  19. Gyrokinetics Simulation of Energetic Particle Turbulence and Transport

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, Patrick H.

    2011-09-21

    Progress in research during this year elucidated the physics of precession resonance and its interaction with radial scattering to form phase space density granulations. Momentum theorems for drift wave-zonal flow systems involving precession resonance were derived. These are directly generalizable to energetic particle modes. A novel nonlinear, subcritical growth mechanism was identified, which has now been verified by simulation. These results strengthen the foundation of our understanding of transport in burning plasmas

  20. Energetics of Amino Acid Synthesis in Alkaline Hydrothermal Environments

    Science.gov (United States)

    Kitadai, Norio

    2015-12-01

    Alkaline hydrothermal systems have received considerable attention as candidates for the origin and evolution of life on the primitive Earth. Nevertheless, sufficient information has not yet been obtained for the thermodynamic properties of amino acids, which are necessary components for life, at high temperatures and alkaline pH. These properties were estimated using experimental high-temperature volume and heat capacity data reported in the literature for several amino acids, together with correlation algorithms and the revised Helgeson-Kirkham-Flowers (HKF) equations of state. This approach enabled determination of a complete set of the standard molal thermodynamic data and the revised HKF parameters for the 20 protein amino acids in their zwitterionic and ionization states. The obtained dataset was then used to evaluate the energetics of amino acid syntheses from simple inorganic precursors (CO2, H2, NH3 and H2S) in a simulated alkaline hydrothermal system on the Hadean Earth. Results show that mixing between CO2-rich seawater and the H2-rich hydrothermal fluid can produce energetically favorable conditions for amino acid syntheses, particularly in the lower-temperature region of such systems. Together with data related to the pH and temperature dependences of the energetics of amino acid polymerizations presented in earlier reports, these results suggest the following. Hadean alkaline hydrothermal settings, where steep pH and temperature gradients may have existed between cool, slightly acidic Hadean ocean water and hot, alkaline hydrothermal fluids at the vent-ocean interface, may be energetically the most suitable environment for the synthesis and polymerization of amino acids.

  1. Energetic constraints to chemo-photometric evolution of spiral galaxies

    CERN Document Server

    Buzzoni, Alberto

    2011-01-01

    The problem of chemo-photometric evolution of late-type galaxies is dealt with relying on prime physical arguments of energetic self-consistency between chemical enhancement of galaxy mass, through nuclear processing inside stars, and luminosity evolution of the system. Chemical enhancement is assessed in terms of the so-called "yield metallicity", that is the metal abundance of processed mass inside stars, as constrained by the galaxy photometric history.

  2. Elution of Energetic Compounds from Propellant and Composition B Residues

    Science.gov (United States)

    2005-07-01

    respective aqueous solubilities (Table 2). In contrast, TNT and the two AmDNTs attained only about 21% and 1% of their respective aque - ous solubilities...sarily the case for TNT and the AmDNTs, the latter of which can covalently bond to organic matter (Thorne and Leggett 1997 ). The percentages relative...55: 357–367. Elution of Energetic Compounds 23 Thorne, P.G., and D.C. Leggett ( 1997 ) Hydrolyic release of bound residues from composted soil

  3. Cellular uptake of metallated cobalamins

    DEFF Research Database (Denmark)

    Tran, Mai Thanh Quynh; Stürup, Stefan; Lambert, Ian Henry

    2016-01-01

    Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass spectrometry (ICP-MS). Vitamin B12 (cyano-cob(iii)alamin) and aquo-cob(iii)alamin [Cbl-OH2](+), which differ in the β-axial ligands (CN...... including [Cbl-OH2](+), [{Co}-CN-{cis-PtCl(NH3)2}](+), [{Re}-{Co}-CN-{cis-PtCl(NH3)2}](+), and [{Co}-CN-{trans-Pt(Cyt)(NH3)2}](2+) (Cyt = cytarabin) was high compared to neutral B12, which implied the existence of an additional internalization pathway for charged B12 vitamin analogs. The affinities...

  4. Discrete geodesics and cellular automata

    CERN Document Server

    Arrighi, Pablo

    2015-01-01

    This paper proposes a dynamical notion of discrete geodesics, understood as straightest trajectories in discretized curved spacetime. The notion is generic, as it is formulated in terms of a general deviation function, but readily specializes to metric spaces such as discretized pseudo-riemannian manifolds. It is effective: an algorithm for computing these geodesics naturally follows, which allows numerical validation---as shown by computing the perihelion shift of a Mercury-like planet. It is consistent, in the continuum limit, with the standard notion of timelike geodesics in a pseudo-riemannian manifold. Whether the algorithm fits within the framework of cellular automata is discussed at length. KEYWORDS: Discrete connection, parallel transport, general relativity, Regge calculus.

  5. Thermomechanical characterisation of cellular rubber

    Science.gov (United States)

    Seibert, H.; Scheffer, T.; Diebels, S.

    2016-09-01

    This contribution discusses an experimental possibility to characterise a cellular rubber in terms of the influence of multiaxiality, rate dependency under environmental temperature and its behaviour under hydrostatic pressure. In this context, a mixed open and closed cell rubber based on an ethylene propylene diene monomer is investigated exemplarily. The present article intends to give a general idea of the characterisation method and the considerable effects of this special type of material. The main focus lies on the experimental procedure and the used testing devices in combination with the analysis methods such as true three-dimensional digital image correlation. The structural compressibility is taken into account by an approach for a material model using the Theory of Porous Media with additional temperature dependence.

  6. Cellular compartmentalization of secondary metabolism

    Directory of Open Access Journals (Sweden)

    H. Corby eKistler

    2015-02-01

    Full Text Available Fungal secondary metabolism is often considered apart from the essential housekeeping functions of the cell. However, there are clear links between fundamental cellular metabolism and the biochemical pathways leading to secondary metabolite synthesis. Besides utilizing key biochemical precursors shared with the most essential processes of the cell (e.g. amino acids, acetyl CoA, NADPH, enzymes for secondary metabolite synthesis are compartmentalized at conserved subcellular sites that position pathway enzymes to use these common biochemical precursors. Co-compartmentalization of secondary metabolism pathway enzymes also may function to channel precursors, promote pathway efficiency and sequester pathway intermediates and products from the rest of the cell. In this review we discuss the compartmentalization of three well-studied fungal secondary metabolite biosynthetic pathways for penicillin G, aflatoxin and deoxynivalenol, and summarize evidence used to infer subcellular localization. We also discuss how these metabolites potentially are trafficked within the cell and may be exported.

  7. Deep energetic trap states in organic photovoltaic devices

    KAUST Repository

    Shuttle, Christopher G.

    2011-11-23

    The nature of energetic disorder in organic semiconductors is poorly understood. In photovoltaics, energetic disorder leads to reductions in the open circuit voltage and contributes to other loss processes. In this work, three independent optoelectronic methods were used to determine the long-lived carrier populations in a high efficiency N-alkylthieno[3,4-c]pyrrole-4,6-dione (TPD) based polymer: fullerene solar cell. In the TPD co-polymer, all methods indicate the presence of a long-lived carrier population of ∼ 10 15 cm -3 on timescales ≤100 μs. Additionally, the behavior of these photovoltaic devices under optical bias is consistent with deep energetic lying trap states. Comparative measurements were also performed on high efficiency poly-3-hexylthiophene (P3HT): fullerene solar cells; however a similar long-lived carrier population was not observed. This observation is consistent with a higher acceptor concentration (doping) in P3HT than in the TPD-based copolymer. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Energetic expenditure of the referee and the assistant soccer referee

    Directory of Open Access Journals (Sweden)

    Alberto Inácio da Silva

    2008-06-01

    Full Text Available The aim of this work was to estimate the energetic expenditure of the soccer referee and the assistant soccer referee during a soccer game. Fourteen soccer referees from Curitiba city were observed, 9 acting as referees (mean age of 36.3 years and body mass of 82 kg and 5 as assistant referees (mean age of 30 years and body mass of 77 kg. They were filmed during official state and national games. The time spent by the referees in each motor action was chronometered by watching the tapes. The energetic expenditure was estimated determining oxygen consumption through the equation suggested by the ACSM (1980 for running and sprinting and the equation suggested by Bubb, Martin and Howley apud Vivacqua e Hespanha (1992 for walking and jogging. The oxygen consumption is a function that depends on the intensity of the realized work and on the dislocated mass. The value of consumed O2 was transformed in kcal multiplying it by 5 (constant kcal per liter of O2. A mean energetic expenditure of 740.42 kcal and 494.64 kcal were observed as results for the referees and assistants, respectively. In conclusion, their physical activity is of moderate intensity, as the performance of the referee and the assistant represented an oxygen consumption equal or less than 16.17 ml/kg/min in 73.98% and 89.97% of the total game time, respectively.

  9. Nanostructured energetic materials derived from sol-gel chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, R L; Tillotson, T M; Hrubesh, L W; Gash, A E

    2000-03-15

    Initiation and detonation properties are dramatically affected by an energetic material's microstructural properties. Sol-gel chemistry allows intimacy of mixing to be controlled and dramatically improved over existing methodologies. One material goal is to create very high power energetic materials which also have high energy densities. Using sol-gel chemistry we have made a nanostructured composite energetic material. Here a solid skeleton of fuel, based on resorcinol-formaldehyde, has nanocrystalline ammonium perchlorate, the oxidizer, trapped within its pores. At optimum stoichiometry it has approximately the energy density of HMX. Transmission electron microscopy indicated no ammonium perchlorate crystallites larger than 20 nm while near-edge soft x-ray absorption microscopy showed that nitrogen was uniformly distributed, at least on the scale of less than 80 nm. Small-angle neutron scattering studies were conducted on the material. Those results were consistent with historical ones for this class of nanostructured materials. The average skeletal primary particle size was on the order of 2.7 nm, while the nanocomposite showed the growth of small 1 nm size crystals of ammonium perchlorate with some clustering to form particles greater than 10 nm.

  10. Rapid decompression and desorption induced energetic failure in coal

    Directory of Open Access Journals (Sweden)

    Shugang Wang

    2015-06-01

    Full Text Available In this study, laboratory experiments are conducted to investigate the rapid decompression and desorption induced energetic failure in coal using a shock tube apparatus. Coal specimens are recovered from Colorado at a depth of 610 m. The coal specimens are saturated with the strong sorbing gas CO2 for a certain period and then the rupture disc is suddenly broken on top of the shock tube to generate a shock wave propagating upwards and a rarefaction wave propagating downwards through the specimen. This rapid decompression and desorption has the potential to cause energetic fragmentation in coal. Three types of behaviors in coal after rapid decompression are found, i.e. degassing without fragmentation, horizontal fragmentation, and vertical fragmentation. We speculate that the characteristics of fracture network (e.g. aperture, spacing, orientation and stiffness and gas desorption play a role in this dynamic event as coal can be considered as a dual porosity, dual permeability, dual stiffness sorbing medium. This study has important implications in understanding energetic failure process in underground coal mines such as coal gas outbursts.

  11. Preparation and reactivity of gasless nanostructured energetic materials.

    Science.gov (United States)

    Manukyan, Khachatur V; Shuck, Christopher E; Rogachev, Alexander S; Mukasyan, Alexander S

    2015-04-02

    High-Energy Ball Milling (HEBM) is a ball milling process where a powder mixture placed in the ball mill is subjected to high-energy collisions from the balls. Among other applications, it is a versatile technique that allows for effective preparation of gasless reactive nanostructured materials with high energy density per volume (Ni+Al, Ta+C, Ti+C). The structural transformations of reactive media, which take place during HEBM, define the reaction mechanism in the produced energetic composites. Varying the processing conditions permits fine tuning of the milling-induced microstructures of the fabricated composite particles. In turn, the reactivity, i.e., self-ignition temperature, ignition delay time, as well as reaction kinetics, of high energy density materials depends on its microstructure. Analysis of the milling-induced microstructures suggests that the formation of fresh oxygen-free intimate high surface area contacts between the reagents is responsible for the enhancement of their reactivity. This manifests itself in a reduction of ignition temperature and delay time, an increased rate of chemical reaction, and an overall decrease of the effective activation energy of the reaction. The protocol provides a detailed description for the preparation of reactive nanocomposites with tailored microstructure using short-term HEBM method. It also describes a high-speed thermal imaging technique to determine the ignition/combustion characteristics of the energetic materials. The protocol can be adapted to preparation and characterization of a variety of nanostructured energetic composites.

  12. Persistent Energetic Electrons in Methylammonium Lead Iodide Perovskite Thin Films.

    Science.gov (United States)

    Niesner, Daniel; Zhu, Haiming; Miyata, Kiyoshi; Joshi, Prakriti P; Evans, Tyler J S; Kudisch, Bryan J; Trinh, M Tuan; Marks, Manuel; Zhu, X-Y

    2016-12-07

    In conventional semiconductor solar cells, carriers are extracted at the band edges and the excess electronic energy (E*) is lost as heat. If E* is harvested, power conversion efficiency can be as high as twice the Shockley-Queisser limit. To date, materials suitable for hot carrier solar cells have not been found due to efficient electron/optical-phonon scattering in most semiconductors, but our recent experiments revealed long-lived hot carriers in single-crystal hybrid lead bromide perovskites. Here we turn to polycrystalline methylammonium lead iodide perovskite, which has emerged as the material for highly efficient solar cells. We observe energetic electrons with excess energy ⟨E*⟩ ≈ 0.25 eV above the conduction band minimum and with lifetime as long as ∼100 ps, which is 2-3 orders of magnitude longer than those in conventional semiconductors. The energetic carriers also give rise to hot fluorescence emission with pseudo-electronic temperatures as high as 1900 K. These findings point to a suppression of hot carrier scattering with optical phonons in methylammonium lead iodide perovskite. We address mechanistic origins of this suppression and, in particular, the correlation of this suppression with dynamic disorder. We discuss potential harvesting of energetic carriers for solar energy conversion.

  13. Screening in crystalline liquids protects energetic carriers in hybrid perovskites

    Science.gov (United States)

    Zhu, Haiming; Miyata, Kiyoshi; Fu, Yongping; Wang, Jue; Joshi, Prakriti P.; Niesner, Daniel; Williams, Kristopher W.; Jin, Song; Zhu, X.-Y.

    2016-09-01

    Hybrid lead halide perovskites exhibit carrier properties that resemble those of pristine nonpolar semiconductors despite static and dynamic disorder, but how carriers are protected from efficient scattering with charged defects and optical phonons is unknown. Here, we reveal the carrier protection mechanism by comparing three single-crystal lead bromide perovskites: CH3NH3PbBr3, CH(NH2)2PbBr3, and CsPbBr3. We observed hot fluorescence emission from energetic carriers with ~102-picosecond lifetimes in CH3NH3PbBr3 or CH(NH2)2PbBr3, but not in CsPbBr3. The hot fluorescence is correlated with liquid-like molecular reorientational motions, suggesting that dynamic screening protects energetic carriers via solvation or large polaron formation on time scales competitive with that of ultrafast cooling. Similar protections likely exist for band-edge carriers. The long-lived energetic carriers may enable hot-carrier solar cells with efficiencies exceeding the Shockley-Queisser limit.

  14. Energetic-particle-driven instabilities in general toroidal configurations

    Energy Technology Data Exchange (ETDEWEB)

    Breizman, B.N. [Institute for Fusion Studies, The University of Texas, Austin, Texas (United States); Brower, D.L.; Deng, C.B. [Department of Physics, University of California, Los Angeles, CA (United States); D' Azevedo, E. [Oak Ridge National Laboratory, Oak Ridge, Tennessee (United States); Konies, A. [Max-Planck Institut fuer Plasmaphysik, EURATOM-Association, Greifswald (Germany); Todo, Y.; Toi, K. [National Institute for Fusion Science (Japan); Spong, D.A.

    2010-08-15

    Energetic-particle driven instabilities have been extensively observed in both tokamaks and stellarators. In order for such devices to ultimately succeed as D-T fusion reactors, the super-Alfvenic 3.5 Mev fusion-produced alpha particles must be sufficiently well confined. This requires the evaluation of losses from classical collisional transport processes as well as from energetic particle-driven instabilities. An important group of instabilities in this context are the discrete shear Alfven modes, which can readily be destabilized by energetic particles (with velocities of the order of v{sub Alfv'en}) through wave-particle resonances. While these modes in three-dimensional systems have many similarities to those in tokamaks, the detailed implementation of modeling tools has required development of new methods. Recent efforts in this direction will be described here, with an emphasis on reduced models (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  15. Modeling thermal/chemical/mechanical response of energetic materials

    Energy Technology Data Exchange (ETDEWEB)

    Baer, M.R.; Hobbs, M.L.; Gross, R.J. [and others

    1995-07-01

    An overview of modeling at Sandia National Laboratories is presented which describes coupled thermal, chemical and mechanical response of energetic materials. This modeling addresses cookoff scenarios for safety assessment studies in systems containing energetic materials. Foundation work is discussed which establishes a method for incorporating chemistry and mechanics into multidimensional analysis. Finite element analysis offers the capabilities to simultaneously resolve reactive heat transfer and structural mechanics in complex geometries. Nonlinear conduction heat transfer, with multiple step finite-rate chemistry, is resolved using a thermal finite element code. Rate equations are solved element-by-element using a modified matrix-free stiff solver This finite element software was developed for the simulation of systems requiring large numbers of finite elements. An iterative implicit scheme, based on the conjugate gradient method, is used and a hemi-cube algorithm is employed for the determination of view factors in surface-to-surface radiation transfer The critical link between the reactive heat transfer and mechanics is the introduction of an appropriate constitutive material model providing a stress-strain relationship for quasi-static mechanics analysis. This model is formally derived from bubble nucleation theory, and parameter variations of critical model parameters indicate that a small degree of decomposition leads to significant mechanical response. Coupled thermal/chemical/mechanical analysis is presented which simulates experiments designed to probe cookoff thermal-mechanical response of energetic materials.

  16. CIRCUMSOLAR ENERGETIC PARTICLE DISTRIBUTION ON 2011 NOVEMBER 3

    Energy Technology Data Exchange (ETDEWEB)

    Gómez-Herrero, R.; Blanco, J.J.; Rodríguez-Pacheco, J. [SRG, Universidad de Alcalá, E-28871 Alcalá de Henares (Spain); Dresing, N.; Klassen, A.; Heber, B.; Banjac, S. [IEAP, Christian-Albrechts-Universität zu Kiel, D-24118 Kiel (Germany); Lario, D. [The Johns Hopkins University, Applied Physics Laboratory, Laurel, MD 20723 (United States); Agueda, N. [Departament d' Astronomia i Meteorologia. Institut de Ciències del Cosmos. Universitat de Barcelona, E-08028 Barcelona (Spain); Malandraki, O. E., E-mail: raul.gomezh@uah.es [IAASARS, National Observatory of Athens, GR-15236 Penteli (Greece)

    2015-01-20

    Late on 2011 November 3, STEREO-A, STEREO-B, MESSENGER, and near-Earth spacecraft observed an energetic particle flux enhancement. Based on the analysis of in situ plasma and particle observations, their correlation with remote sensing observations, and an interplanetary transport model, we conclude that the particle increases observed at multiple locations had a common single-source active region and the energetic particles filled a very broad region around the Sun. The active region was located at the solar backside (as seen from Earth) and was the source of a large flare, a fast and wide coronal mass ejection, and an EIT wave, accompanied by type II and type III radio emission. In contrast to previous solar energetic particle events showing broad longitudinal spread, this event showed clear particle anisotropies at three widely separated observation points at 1 AU, suggesting direct particle injection close to the magnetic footpoint of each spacecraft, lasting for several hours. We discuss these observations and the possible scenarios explaining the extremely broad particle spread for this event.

  17. Energetic consequences of thermal and nonthermal food processing.

    Science.gov (United States)

    Carmody, Rachel N; Weintraub, Gil S; Wrangham, Richard W

    2011-11-29

    Processing food extensively by thermal and nonthermal techniques is a unique and universal human practice. Food processing increases palatability and edibility and has been argued to increase energy gain. Although energy gain is a well-known effect from cooking starch-rich foods, the idea that cooking meat increases energy gain has never been tested. Moreover, the relative energetic advantages of cooking and nonthermal processing have not been assessed, whether for meat or starch-rich foods. Here, we describe a system for characterizing the energetic effects of cooking and nonthermal food processing. Using mice as a model, we show that cooking substantially increases the energy gained from meat, leading to elevations in body mass that are not attributable to differences in food intake or activity levels. The positive energetic effects of cooking were found to be superior to the effects of pounding in both meat and starch-rich tubers, a conclusion further supported by food preferences in fasted animals. Our results indicate significant contributions from cooking to both modern and ancestral human energy budgets. They also illuminate a weakness in current food labeling practices, which systematically overestimate the caloric potential of poorly processed foods.

  18. 2 pi-Steradian, Energetic-Ion Sensor

    CERN Document Server

    Mitchell, Donald G

    2010-01-01

    Because energetic particles populate both planetary magnetospheres and interplanetary space in significant quantities, energetic-ion sensors have been flown since the beginning of the space age. Early sensors were solid-state detector (SSD) telescopes, with conical fields of view, often swept through a circle by virtue of the spin motion of the spacecraft (e.g., IMP 7 and 8, ISEE 1 and 2). In the 1980s and 1990s, foil/microchannel plate (MCP) time-of-flight (TOF) measurements were added to the energy measurement provided by the SSD (eg, AMPTE/CCE MEPA, Geotail EPIC/ICS, Galileo EPD). The resulting energy and velocity uniquely identified ion mass. More recently, we have developed a 2-D fan acceptance angle sensor that includes both energy and TOF. When mounted on a spinning spacecraft, this 160^\\circ x 12^\\circ FOV sweeps out nearly 4\\pi steradians in one spin. This sensor, dubbed the "hockey puck" for its shape, is currently in flight on MESSENGER (EPS) and New Horizons Pluto (PEPPSI).Increasingly, energetic-...

  19. Mitochondrial and cellular mechanisms for managing lipid excess

    Directory of Open Access Journals (Sweden)

    Miguel A Aon

    2014-07-01

    Full Text Available Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with heart dysfunction in obesity and diabetes. Mitochondria play a fundamental role in aging and in prevalent acute or chronic diseases. Lipids are main mitochondrial fuels however these molecules can also behave as uncouplers and inhibitors of oxidative phosphorylation. Knowledge about the functional composition of these contradictory effects and their impact on mitochondrial-cellular energetics/redox status is incomplete.Cells store fatty acids (FAs as triacylglycerol and package them into cytoplasmic lipid droplets (LDs. New emerging data shows the LD as a highly dynamic storage pool of FAs that can be used for energy reserve. Lipid excess packaging into LDs can be seen as an adaptive response to fulfilling energy supply without hindering mitochondrial or cellular redox status and keeping low concentration of lipotoxic intermediates.Herein we review the mechanisms of action and utilization of lipids by mitochondria reported in liver, heart and skeletal muscle under relevant physiological situations, e.g. exercise. We report on perilipins, a family of proteins that associate with LDs in response to loading of cells with lipids. Evidence showing that in addition to physical contact, mitochondria and LDs exhibit metabolic interactions is presented and discussed. A hypothetical model of channeled lipid utilization by mitochondria is proposed. Direct delivery and channeled processing of lipids in mitochondria could represent a reliable and efficient way to maintain ROS within levels compatible with signaling while ensuring robust and reliable energy supply.

  20. Energetic modeling and single-molecule verification of dynamic regulation on receptor complexes by actin corrals and lipid raft domains

    Science.gov (United States)

    Lin, Chien Y.; Huang, Jung Y.; Lo, Leu-Wei

    2014-12-01

    We developed an energetic model by integrating the generalized Langevin equation with the Cahn-Hilliard equation to simulate the diffusive behaviors of receptor proteins in the plasma membrane of a living cell. Simulation results are presented to elaborate the confinement effects from actin corrals and protein-induced lipid domains. Single-molecule tracking data of epidermal growth factor receptors (EGFR) acquired on live HeLa cells agree with the simulation results and the mechanism that controls the diffusion of single-molecule receptors is clarified. We discovered that after ligand binding, EGFR molecules move into lipid nanodomains. The transition rates between different diffusion states of liganded EGFR molecules are regulated by the lipid domains. Our method successfully captures dynamic interactions of receptors at the single-molecule level and provides insight into the functional architecture of both the diffusing EGFR molecules and their local cellular environment.

  1. Vegetarian diet and blood pressure.

    Science.gov (United States)

    Beilin, L J; Armstrong, B K; Margetts, B M; Rouse, I L; Vandongen, R

    1987-01-01

    There is now convincing evidence from epidemiological studies and randomized controlled trials that adoption of an ovo-lacto vegetarian diet leads to blood pressure reduction in both normotensive and hypertensive subjects. This effect appears to be independent of both dietary sodium and weight loss but additive to effects of weight reduction. Long-term adherence to a vegetarian diet is associated with less of a rise of blood pressure with age and a decreased prevalence of hypertension. The nutrients responsible for these effects have not been clearly identified and the mechanisms involved are unknown. Resolution of these questions is needed to enable more widespread adoption of dietary changes which may reduce the prevalence of hypertension, reduce antihypertensive drug dependence and by effects on blood pressure and blood lipids ameliorate the natural history of hypertensive cardiovascular disease.

  2. [Diet therapy in Parkinson disease].

    Science.gov (United States)

    Vilming, S T

    1995-04-20

    The significance of restrictions on protein for patients with Parkinson's disease is reviewed. Large neutral amino acids and levodopa share the same saturated carrier system through the blood-brain-barrier. Fluctuating patients are sensitive to a decreased supply of levodopa from the blood, and clinical studies show that an increased concentration of large neutral amino acids in the blood decreases mobility and reduces "on-time". A reduction of protein intake to 0.75-0.8 g/kg body weight/day has been recommended. A protein redistribution diet implying that less than 10% of the daily protein is taken in daytime and the rest in the evening, gives best results. However, in the elderly, protein restrictions may lead to a lasting negative nitrogen balance, and even in younger patients the supply of certain minerals and vitamins may become too low or marginally adequate. The diet must therefore be used with caution.

  3. Thermodynamics of weight loss diets

    Directory of Open Access Journals (Sweden)

    Fine Eugene J

    2004-12-01

    Full Text Available Abstract Background It is commonly held that "a calorie is a calorie", i.e. that diets of equal caloric content will result in identical weight change independent of macronutrient composition, and appeal is frequently made to the laws of thermodynamics. We have previously shown that thermodynamics does not support such a view and that diets of different macronutrient content may be expected to induce different changes in body mass. Low carbohydrate diets in particular have claimed a "metabolic advantage" meaning more weight loss than in isocaloric diets of higher carbohydrate content. In this review, for pedagogic clarity, we reframe the theoretical discussion to directly link thermodynamic inefficiency to weight change. The problem in outline: Is metabolic advantage theoretically possible? If so, what biochemical mechanisms might plausibly explain it? Finally, what experimental evidence exists to determine whether it does or does not occur? Results Reduced thermodynamic efficiency will result in increased weight loss. The laws of thermodynamics are silent on the existence of variable thermodynamic efficiency in metabolic processes. Therefore such variability is permitted and can be related to differences in weight lost. The existence of variable efficiency and metabolic advantage is therefore an empiric question rather than a theoretical one, confirmed by many experimental isocaloric studies, pending a properly performed meta-analysis. Mechanisms are as yet unknown, but plausible mechanisms at the metabolic level are proposed. Conclusions Variable thermodynamic efficiency due to dietary manipulation is permitted by physical laws, is supported by much experimental data, and may be reasonably explained by plausible mechanisms.

  4. Ion energetics at Saturn's magnetosphere using Cassini/MIMI measurements: A simple model for the energetic ion integral moments

    Science.gov (United States)

    Dialynas, K.; Paranicas, C.; Roussos, E.; Krimigis, S. M.; Kane, M.; Mitchell, D. G.

    2015-12-01

    We present a composite analysis (H+ and O+) of energetic ion spectra and kappa distribution fits, using combined ion measurements from Charge Energy Mass Spectrometer (CHEMS, 3 to 236 keV/e), Low Energy Magnetospheric Measurements System (LEMMS, 0.024 220 keV for H+). The modeled expressions of these energetic ion distributions are then used to obtain the four integral particle moments (from zeroth to 3rd moment: n, In, P, IE, i.e. Density, Integral number intensity, Pressure, Integral energy intensity) as well as the characteristic energy (EC=IE/In) of these ions as a function of Local Time and L-Shell. We find that a) protons dominate the energetic ion (>30 keV) integral number and energy intensity at all radial distances (L>5 Rs) and local times, while the H+ and O+ partial pressures and densities are comparable; b) the 12Skinner [2000] model in both local time and L-shell. Roelof, E. C., and A. J. Skinner (2000), Space Sci. Rev., 91, 437-459.

  5. Functional bowel symptoms and diet.

    Science.gov (United States)

    Gibson, P R; Barrett, J S; Muir, J G

    2013-10-01

    It is well recognised that ingestion of food is a trigger for functional bowel symptoms, particularly those associated with irritable bowel syndrome (IBS). Patients often use manipulation of diet as a means of controlling symptoms. Despite description of multiple dietary methods, few have scientific backing or quality evidence of efficacy. One approach is to define how specific food components influence the pathophysiology of IBS and then rationally design dietary approaches. For example, short-chain poorly absorbed carbohydrates (fermentable oligo-, di- and mono-saccharides and polyols (FODMAP)) cause luminal distension, which is a major stimulus for the development of symptoms in patients with visceral hypersensitivity. By determining food content of FODMAP, a diet in which foods low in FODMAP are favoured over those high in FODMAP can be designed. Observational, comparative and randomised controlled treatment and rechallenge studies have shown that such an approach is efficacious in the majority of patients with IBS. The low FODMAP diet is now the primary dietary therapy for such patients. Similar approaches can be applied to other food components, including proteins (such as gluten), fats and natural bioactive food chemicals. Such approaches have suggestions of efficacy, but the evidence base remains underdeveloped. An additional and important consideration for any dietary therapy is its nutritional adequacy and potential adverse health effects. Dietary manipulation is now a key management strategy in patients with functional bowel symptoms. Future well-designed interventional studies will lead to refinement of dietary approaches taken and to a better understanding of their long-term safety.

  6. Inequalities in diet and nutrition.

    Science.gov (United States)

    Tiffin, Richard; Salois, Matthew

    2012-02-01

    The inequality of nutrition and obesity re-focuses concern on who in society is consuming the worst diet. Identification of individuals with the worst of dietary habits permits for targeting interventions to assuage obesity among the population segment where it is most prevalent. We argue that the use of fiscal interventions does not appropriately take into account the economic, social and health circumstances of the intended beneficiaries of the policy. This paper reviews the influence of socio-demographic factors on nutrition and health status and considers the impacts of nutrition policy across the population drawing on methodologies from both public health and welfare economics. The effects of a fat tax on diet are found to be small and while other studies show that fat taxes saves lives, we show that average levels of disease risk do not change much: those consuming particularly bad diets continue to do so. Our results also suggest that the regressivity of the policy increases as the tax becomes focused on products with high saturated fat contents. A fiscally neutral policy that combines the fat tax with a subsidy on fruit and vegetables is actually more regressive because consumption of these foods tends to be concentrated in socially undeserving households. We argue that when inequality is of concern, population-based measures must reflect this and approaches that target vulnerable populations which have a shared propensity to adopt unhealthy behaviours are appropriate.

  7. Feed quality in swine diet

    Directory of Open Access Journals (Sweden)

    Živković Branislav

    2002-01-01

    Full Text Available The paper will demonstrate the quality of some feed used in swine diet. The emphasis will be on feed whose incorporation into mixes could result in unfavorable effects on production, health and economic production of swine. Data will be presented on maize and its possible negative effects, having in mind toxins. Soybean meal, or genetically modified soybean meal, will also be observed. The next feed which will be discussed will be soybean whey obtained by different procedures and the potential dangers of its use in swine diet rations. Sunflower meal, feed of animal origin, with emphasis on fish flour and meat-bone flour will also be covered in the work. A feed which has been attracting particular attention lately is yeast imported from Italy. Its quality characteristics will be discussed, the so-called non-protein nitrogen. Analyses of mineral feed will include sources of phosphorus, phosphates (monocalciumphosphate, dicalcium phosphate phytases and resolving the problem of phosphorus in swine rations. Finally, an inevitable segment are synthetic amino acids, especially lysine and its role in swine diet.

  8. Energetic Particle Diagnostics for Transport Analysis 3.Escaping Fast Ion Diagnostics for the Fast Particle Transport Analysis

    Science.gov (United States)

    Isobe, Mitsutaka; Shinohara, Kouji

    Escaping energetic ion diagnostics in magnetically confined plasma experiments are described in this lecture note. Experimental results from escaping energetic ion diagnostics in TFTR, JFT-2M, CHS and W7-AS are shown. In addition to mechanism of energetic ion loss from a viewpoint of particle orbit, effect of MHD activity on energetic particle transport is reviewed.

  9. Combined effects of resistance training and carbohydrate-restrictive or conventional diets on weight loss, blood variables and endothelium function

    Directory of Open Access Journals (Sweden)

    Claudia Mello MEIRELLES

    Full Text Available ABSTRACT Objective: To compare the effects of either a carbohydrate-restrictive diets or a conventional hypoenergetic diet combined with resistance training. Methods: Twenty-one overweight and obese adults participated in an eight-week program consisting of progressive resistance training combined with carbohydrate-restrictive diets (initially set at <30 g carbohydrate; n=12 or conventional hypoenergetic diet (30% energetic restriction; carbohydrate/protein/lipid: 51/18/31% of total energy consumption; n=9. It was hypothesized that the carbohydrate-restrictive diets would induce greater weight loss but that both diets would elicit similar effects on selected health markers. Body mass, and body composition, blood variables and flow-mediated brachial artery dilation (flow-mediated brachial artery dilation; by ultrasound were used to assess changes due to the interventions. Results: Significant within-group reductions in body mass (-5.4±3.5%; p=0.001 versus -3.7±3.0%; p=0.015 and body fat (body fat; -10.2±7.0%; p=0.005 versus -9.6±8.8%; p=0.017 were identified for carbohydrate-restrictive diets and conventional hypoenergetic diet, respectively, but there were no significant differences between groups as the result of the interventions. Fat free mass, blood variables and flow-mediated brachial artery dilation did not significantly change, except for the total cholesterol/high-density lipoprotein ratio, which was reduced 10.4±16.9% in carbohydrate-restrictive diets (p=0.037 and 0.5±11.3% in conventional hypoenergetic diet (p=0.398. Conclusion: Carbohydrate-restrictive diets associated with resistance training was as effective as conventional hypoenergetic diet in decreasing body mass and body fat, as well as maintaining fat free mass, blood variables and flow-mediated brachial artery dilation, however it was more effective at lowering the total cholesterol/low density lipoprotein ratio.

  10. Intrinsic Simulations between Stochastic Cellular Automata

    Directory of Open Access Journals (Sweden)

    Pablo Arrighi

    2012-08-01

    Full Text Available The paper proposes a simple formalism for dealing with deterministic, non-deterministic and stochastic cellular automata in a unifying and composable manner. Armed with this formalism, we extend the notion of intrinsic simulation between deterministic cellular automata, to the non-deterministic and stochastic settings. We then provide explicit tools to prove or disprove the existence of such a simulation between two stochastic cellular automata, even though the intrinsic simulation relation is shown to be undecidable in dimension two and higher. The key result behind this is the caracterization of equality of stochastic global maps by the existence of a coupling between the random sources. We then prove that there is a universal non-deterministic cellular automaton, but no universal stochastic cellular automaton. Yet we provide stochastic cellular automata achieving optimal partial universality.

  11. THE RELATIONSHIPS OF THREE ELEMENTARY CELLULAR AUTOMATA

    Institute of Scientific and Technical Information of China (English)

    Zhisong JIANG

    2006-01-01

    Limit language complexity of cellular automata which is first posed by S. Wolfram has become a new branch of cellular automata. In this paper, we obtain two interesting relationships between elementary cellular automata of rules 126, 146(182) and 18, and prove that if the limit language of rule 18 is not regular, nor are the limit languages of rules 126 and 146(182).

  12. Autophagy and mitophagy in cellular damage control

    Directory of Open Access Journals (Sweden)

    Jianhua Zhang

    2013-01-01

    Full Text Available Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules. This graphic review gives a broad summary of autophagy and discusses examples where autophagy is important in controlling protein degradation. In addition we highlight how autophagy and mitophagy are involved in the cellular responses to reactive species and mitochondrial dysfunction. The key signaling pathways for mitophagy are described in the context of bioenergetic dysfunction.

  13. Efficiency of cellular information processing

    CERN Document Server

    Barato, Andre C; Seifert, Udo

    2014-01-01

    We show that a rate of conditional Shannon entropy reduction, characterizing the learning of an internal process about an external process, is bounded by the thermodynamic entropy production. This approach allows for the definition of an informational efficiency that can be used to study cellular information processing. We analyze three models of increasing complexity inspired by the E. coli sensory network, where the external process is an external ligand concentration jumping between two values. We start with a simple model for which ATP must be consumed so that a protein inside the cell can learn about the external concentration. With a second model for a single receptor we show that the rate at which the receptor learns about the external environment can be nonzero even without any dissipation inside the cell since chemical work done by the external process compensates for this learning rate. The third model is more complete, also containing adaptation. For this model we show inter alia that a bacterium i...

  14. The origins of cellular life.

    Science.gov (United States)

    Schrum, Jason P; Zhu, Ting F; Szostak, Jack W

    2010-09-01

    Understanding the origin of cellular life on Earth requires the discovery of plausible pathways for the transition from complex prebiotic chemistry to simple biology, defined as the emergence of chemical assemblies capable of Darwinian evolution. We have proposed that a simple primitive cell, or protocell, would consist of two key components: a protocell membrane that defines a spatially localized compartment, and an informational polymer that allows for the replication and inheritance of functional information. Recent studies of vesicles composed of fatty-acid membranes have shed considerable light on pathways for protocell growth and division, as well as means by which protocells could take up nutrients from their environment. Additional work with genetic polymers has provided insight into the potential for chemical genome replication and compatibility with membrane encapsulation. The integration of a dynamic fatty-acid compartment with robust, generalized genetic polymer replication would yield a laboratory model of a protocell with the potential for classical Darwinian biological evolution, and may help to evaluate potential pathways for the emergence of life on the early Earth. Here we discuss efforts to devise such an integrated protocell model.

  15. The cellular toxicity of aluminium.

    Science.gov (United States)

    Exley, C; Birchall, J D

    1992-11-07

    Aluminium is a serious environmental toxicant and is inimical to biota. Omnipresent, it is linked with a number of disorders in man including Alzheimer's disease, Parkinson's dementia and osteomalacia. Evidence supporting aluminium as an aetiological agent in such disorders is not conclusive and suffers principally from a lack of consensus with respect to aluminium's toxic mode of action. Obligatory to the elucidation of toxic mechanisms is an understanding of the biological availability of aluminium. This describes the fate of and response to aluminium in any biological system and is thus an important influence of the toxicity of aluminium. A general theme in much aluminium toxicity is an accelerated cell death. Herein mechanisms are described to account for cell death from both acute and chronic aluminium challenges. Aluminium associations with both extracellular surfaces and intracellular ligands are implicated. The cellular response to aluminium is found to be biphasic having both stimulatory and inhibitory components. In either case the disruption of second messenger systems is observed and GTPase cycles are potential target sites. Specific ligands for aluminium at these sites are unknown though are likely to be proteins upon which oxygen-based functional groups are orientated to give exceptionally strong binding with the free aluminium ion.

  16. Integration of mobile satellite and cellular systems

    Science.gov (United States)

    Drucker, Elliott H.; Estabrook, Polly; Pinck, Deborah; Ekroot, Laura

    1993-01-01

    By integrating the ground based infrastructure component of a mobile satellite system with the infrastructure systems of terrestrial 800 MHz cellular service providers, a seamless network of universal coverage can be established. Users equipped for both cellular and satellite service can take advantage of a number of features made possible by such integration, including seamless handoff and universal roaming. To provide maximum benefit at lowest posible cost, the means by which these systems are integrated must be carefully considered. Mobile satellite hub stations must be configured to efficiently interface with cellular Mobile Telephone Switching Offices (MTSO's), and cost effective mobile units that provide both cellular and satellite capability must be developed.

  17. Optimized Cellular Core for Rotorcraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Patz Materials and Technologies proposes to develop a unique structural cellular core material to improve mechanical performance, reduce platform weight and lower...

  18. Is a vegetarian diet adequate for children.

    Science.gov (United States)

    Hackett, A; Nathan, I; Burgess, L

    1998-01-01

    The number of people who avoid eating meat is growing, especially among young people. Benefits to health from a vegetarian diet have been reported in adults but it is not clear to what extent these benefits are due to diet or to other aspects of lifestyles. In children concern has been expressed concerning the adequacy of vegetarian diets especially with regard to growth. The risks/benefits seem to be related to the degree of restriction of he diet; anaemia is probably both the main and the most serious risk but this also applies to omnivores. Vegan diets are more likely to be associated with malnutrition, especially if the diets are the result of authoritarian dogma. Overall, lacto-ovo-vegetarian children consume diets closer to recommendations than omnivores and their pre-pubertal growth is at least as good. The simplest strategy when becoming vegetarian may involve reliance on vegetarian convenience foods which are not necessarily superior in nutritional composition. The vegetarian sector of the food industry could do more to produce foods closer to recommendations. Vegetarian diets can be, but are not necessarily, adequate for children, providing vigilance is maintained, particularly to ensure variety. Identical comments apply to omnivorous diets. Three threats to the diet of children are too much reliance on convenience foods, lack of variety and lack of exercise.

  19. The New Nordic Diet as a prototype for regional sustainable diets

    DEFF Research Database (Denmark)

    Bügel, Susanne Gjedsted; Hertwig, Jostein; Kahl, Johannes

    2016-01-01

    A main challenge in sustainable food systems is to link sustainable production to sustainable diets and consumption patterns. The new Nordic diet (NND) builds on and shares the Mediterranean diet (MD) thinking, but utilizes the ingredients and flavours of a northern climate. In both diets...... both wild and domesticated sources. Both diets have been associated with health benefits. The NND is a prototype regional diet taking health, food culture, palatability and the environment into account. Thus, the principles and guidelines could be applied in any region of the world. There are currently...

  20. Instantaneous Wavelet Energetic Transfers between Atmospheric Blocking and Local Eddies.

    Science.gov (United States)

    Fournier, Aimé

    2005-07-01

    A new wavelet energetics technique, based on best-shift orthonormal wavelet analysis (OWA) of an instantaneous synoptic map, is constructed for diagnosing nonlinear kinetic energy (KE) transfers in five observed blocking cases. At least 90% of the longitudinal variance of time and latitude band mean 50-kPa geopotential is reconstructed by only two wavelets using best shift. This superior efficiency to the standard OWAs persists for time-evolving structures. The cases comprise two categories, respectively dominated by zonal-wavenumber sets {1} and {1, 2}. Further OWA of instantaneous residual nonblocking structures, combined with new “nearness” criteria, yields three more orthogonal components, representing smaller-scale eddies near the block (upstream and downstream) and distant structures. This decomposition fulfills a vision expressed to the author by Saltzman. Such a decomposition is not obtainable by simple Fourier analysis.Eddy patterns apparent in the components' contours suggest inferring geostrophic energetic interactions, but the component Rossby numbers may be too large to support the inference. However, a new result enabled by this method is the instantaneous attribution of blocking strain-field effects to particular energetically interactive eddies, consistent with Shutts' hypothesis. Such attribution was only possible before in simplified models or in a time-average sense. In four of five blocks, the upstream eddies feed KE to the block, which in turn, in three of four cases, transmits KE to the downstream eddies. The small case size precludes statistically significant conclusions. The appendixes link low-order blocking structure and dynamics to some wavelet design principles and propose a new interaction diagnosis, similar to E-vector analysis, but instantaneous.