WorldWideScience

Sample records for cellular circuits orchestrating

  1. Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans.

    Directory of Open Access Journals (Sweden)

    Xiaorong Lin

    2010-05-01

    Full Text Available Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic transition from a unicellular yeast to multicellular hyphae during opposite sex (mating and unisexual reproduction (same-sex mating. Opposite- and same-sex mating are induced by similar environmental conditions and involve many shared components, including the conserved pheromone sensing Cpk1 MAPK signal transduction cascade that governs the dimorphic switch in C. neoformans. However, the homeodomain cell identity proteins Sxi1alpha/Sxi2a encoded by the mating type locus that are essential for completion of sexual reproduction following cell-cell fusion during opposite-sex mating are dispensable for same-sex mating. Therefore, identification of downstream targets of the Cpk1 MAPK pathway holds the key to understanding molecular mechanisms governing the two distinct developmental fates. Thus far, homology-based approaches failed to identify downstream transcription factors which may therefore be species-specific. Here, we applied insertional mutagenesis via Agrobacterium-mediated transformation and transcription analysis using whole genome microarrays to identify factors involved in C. neoformans differentiation. Two transcription factors, Mat2 and Znf2, were identified as key regulators of hyphal growth during same- and opposite-sex mating. Mat2 is an HMG domain factor, and Znf2 is a zinc finger protein; neither is encoded by the mating type locus. Genetic, phenotypic, and transcriptional analyses of Mat2 and Znf2 provide evidence that Mat2 is a downstream transcription factor of the Cpk1 MAPK pathway whereas Znf2 functions as a more terminal hyphal morphogenesis determinant. Although the components of the MAPK pathway including Mat2 are not required for virulence in animal models, Znf2, as a hyphal morphology determinant, is a negative regulator of virulence. Further characterization of these elements and their target circuits will reveal genes controlling biological

  2. Orchestrating innovation

    NARCIS (Netherlands)

    Berkers, F.T.H.M.; Klein Woolthuis, R.J.A.; Boer, J. de

    2015-01-01

    Orchestrating Innovation increases the probability of success, minimizing the probability of failure of technological innovations by creating sustained societal and economic value. Orchestrating innovation propagates to take into account and actively involve all relevant stakeholders of the (future)

  3. Exploring Quantum Dot Cellular Automata Based Reversible Circuit

    Directory of Open Access Journals (Sweden)

    Saroj Kumar Chandra

    2012-03-01

    Full Text Available Quantum-dot Cellular Automata (QCA is a new technology for development of logic circuits based on nanotechnology, and it is an one of the alternative for designing high performance computing over existing CMOS technology. The basic logic in QCA does not use voltage level for logic representation rather it represent binary state by polarization of electrons on the Quantum Cell which is basic building block of QCA. Extensive work is going on QCA for circuit design due to low power consumption and regularity in the circuit.. Clocking is used in QCA circuit to synchronize and control the information flow and to provide the power to run the circuit. Reversible logic design is a well-known paradigm in digital computation, and if circuit developed is reversible then it consumes very low power. Here, in this paper we are presenting a Reversible Universal Gate (RUG based on Quantum-dot Cellular Automata (QCA. The RUG implemented by QCA Designer tool and also its behavior is simulated by it.

  4. Exploring Quantum Dot Cellular Automata Based Reversible Circuit

    Directory of Open Access Journals (Sweden)

    Saroj Kumar Chandra

    2012-03-01

    Full Text Available Quantum-dot Cellular Automata (QCA is a new technology for development of logic circuits based on nanotechnology, and it is an one of the alternative for designing high performance computing over existing CMOS technology. The basic logic in QCA does not use voltage level for logic representation rather it represent binary state by polarization of electrons on the Quantum Cell which is basic building block of QCA. Extensive work is going on QCA for circuit design due to low power consumption and regularity in the circuit.. Clocking is used in QCA circuit to synchronize and control the information flow and to provide the power to run the circuit. Reversible logic design is a well-known paradigm in digital computation, and if circuit developed is reversible then it consumes very low power . Here, in this paper we are presenting a Reversible Universal Gate (RUG based on Quantum-dot Cellular Automata (QCA. The RUG implemented by QCA Designer tool and also its behavior is simulated by it.

  5. Chaotic phenomena in Josephson circuits coupled quantum cellular neural networks

    Institute of Scientific and Technical Information of China (English)

    Wang Sen; Cai Li; Li Qin; Wu Gang

    2007-01-01

    In this paper the nonlinear dynamical behaviour of a quantum cellular neural network (QCNN) by coupling Josephson circuits was investigated and it was shown that the QCNN using only two of them can cause the onset of chaotic oscillation. The theoretical analysis and simulation for the two Josephson-circuits-coupled QCNN have been done by using the amplitude and phase as state variables. The complex chaotic behaviours can be observed and then proved by calculating Lyapunov exponents. The study provides valuable information about QCNNs for future application in high-parallel signal processing and novel chaotic generators.

  6. Orchestrating innovation

    OpenAIRE

    Berkers, F.T.H.M.; Klein Woolthuis, R.J.A.; J. de Boer

    2015-01-01

    Orchestrating Innovation increases the probability of success, minimizing the probability of failure of technological innovations by creating sustained societal and economic value. Orchestrating innovation propagates to take into account and actively involve all relevant stakeholders of the (future) ecosystem in which the innovation will, can or has to be adopted.

  7. Design of arithmetic circuits in quantum dot cellular automata nanotechnology

    CERN Document Server

    Sridharan, K

    2015-01-01

    This research monograph focuses on the design of arithmetic circuits in Quantum Dot Cellular Automata (QCA). Using the fact that the 3-input majority gate is a primitive in QCA, the book sets out to discover hitherto unknown properties of majority logic in the context of arithmetic circuit designs. The pursuit for efficient adders in QCA takes two forms. One involves application of the new results in majority logic to existing adders. The second involves development of a custom adder for QCA technology. A QCA adder named as hybrid adder is proposed and it is shown that it outperforms existing multi-bit adders with respect to area and delay. The work is extended to the design of a low-complexity multiplier for signed numbers in QCA. Furthermore the book explores two aspects unique to QCA technology, namely thermal robustness and the role of interconnects. In addition, the book introduces the reader to QCA layout design and simulation using QCADesigner. Features & Benefits: This research-based book: ·  �...

  8. Orchestrating Docker

    CERN Document Server

    Holla, Shrikrishna

    2015-01-01

    If you are a competent developer or DevOps with a good understanding of Linux filesystems but want to manage and orchestrate Docker services, images, and products using a multitude of techniques, then this book is for you. No prior knowledge of Docker or container virtualization is required.

  9. Synthetic analog and digital circuits for cellular computation and memory

    OpenAIRE

    Purcell, Oliver; Lu, Timothy K.

    2014-01-01

    Biological computation is a major area of focus in synthetic biology because it has the potential to enable a wide range of applications. Synthetic biologists have applied engineering concepts to biological systems in order to construct progressively more complex gene circuits capable of processing information in living cells. Here, we review the current state of computational genetic circuits and describe artificial gene circuits that perform digital and analog computation. We then discuss r...

  10. CodY orchestrates the expression of virulence determinants in emetic Bacillus cereus by impacting key regulatory circuits.

    Science.gov (United States)

    Frenzel, Elrike; Doll, Viktoria; Pauthner, Matthias; Lücking, Genia; Scherer, Siegfried; Ehling-Schulz, Monika

    2012-07-01

    Bacillus cereus causes gastrointestinal diseases and local and systemic infections elicited by the depsipeptide cereulide, enterotoxins, phospholipases, cytolysins and proteases. The PlcR-PapR quorum sensing system activates the expression of several virulence factors, whereas the Spo0A-AbrB regulatory circuit partially controls the plasmid-borne cereulide synthetase (ces) operon. Here, we show that CodY, a nutrient-responsive regulator of Gram-positive bacteria, has a profound effect on both regulatory systems, which have been assumed to operate independently of each other. Deletion of codY resulted in downregulation of virulence genes belonging to the PlcR regulon and a concomitant upregulation of the ces genes. CodY was found to be a repressor of the ces operon, but did not interact with the promoter regions of PlcR-dependent virulence genes in vitro, suggesting an indirect regulation of the latter. Furthermore, CodY binds to the promoter of the immune inhibitor metalloprotease InhA1, demonstrating that CodY directly links B. cereus metabolism to virulence. In vivo studies using a Galleria mellonella infection model, showed that the codY mutant was substantially attenuated, highlighting the importance of CodY as a key regulator of pathogenicity. Our results demonstrate that CodY profoundly modulates the virulence of B. cereus, possibly controlling the development of pathogenic traits in suitable host environments.

  11. Isocost Lines Describe the Cellular Economy of Genetic Circuits.

    Science.gov (United States)

    Gyorgy, Andras; Jiménez, José I; Yazbek, John; Huang, Hsin-Ho; Chung, Hattie; Weiss, Ron; Del Vecchio, Domitilla

    2015-08-04

    Genetic circuits in living cells share transcriptional and translational resources that are available in limited amounts. This leads to unexpected couplings among seemingly unconnected modules, which result in poorly predictable circuit behavior. In this study, we determine these interdependencies between products of different genes by characterizing the economy of how transcriptional and translational resources are allocated to the production of proteins in genetic circuits. We discover that, when expressed from the same plasmid, the combinations of attainable protein concentrations are constrained by a linear relationship, which can be interpreted as an isocost line, a concept used in microeconomics. We created a library of circuits with two reporter genes, one constitutive and the other inducible in the same plasmid, without a regulatory path between them. In agreement with the model predictions, experiments reveal that the isocost line rotates when changing the ribosome binding site strength of the inducible gene and shifts when modifying the plasmid copy number. These results demonstrate that isocost lines can be employed to predict how genetic circuits become coupled when sharing resources and provide design guidelines for minimizing the effects of such couplings.

  12. Pavlovian Conditioning of "Hermissenda": Current Cellular, Molecular, and Circuit Perspectives

    Science.gov (United States)

    Crow, Terry

    2004-01-01

    The less-complex central nervous system of many invertebrates make them attractive for not only the molecular analysis of the associative learning and memory, but also in determining how neural circuits are modified by learning to generate changes in behavior. The nudibranch mollusk "Hermissenda crassicornis" is a preparation that has contributed…

  13. Orchestrated Session Compliance

    Directory of Open Access Journals (Sweden)

    Franco Barbanera

    2015-08-01

    Full Text Available We investigate the notion of orchestrated compliance for client/server interactions in the context of session contracts. Devising the notion of orchestrator in such a context makes it possible to have orchestrators with unbounded buffering capabilities and at the same time to guarantee any message from the client to be eventually delivered by the orchestrator to the server, while preventing the server from sending messages which are kept indefinitely inside the orchestrator. The compliance relation is shown to be decidable by means of 1 a procedure synthesising the orchestrators, if any, making a client compliant with a server, and 2 a procedure for deciding whether an orchestrator behaves in a proper way as mentioned before.

  14. Integrated Circuit-Based Biofabrication with Common Biomaterials for Probing Cellular Biomechanics.

    Science.gov (United States)

    Sung, Chun-Yen; Yang, Chung-Yao; Yeh, J Andrew; Cheng, Chao-Min

    2016-02-01

    Recent advances in bioengineering have enabled the development of biomedical tools with modifiable surface features (small-scale architecture) to mimic extracellular matrices and aid in the development of well-controlled platforms that allow for the application of mechanical stimulation for studying cellular biomechanics. An overview of recent developments in common biomaterials that can be manufactured using integrated circuit-based biofabrication is presented. Integrated circuit-based biofabrication possesses advantages including mass and diverse production capacities for fabricating in vitro biomedical devices. This review highlights the use of common biomaterials that have been most frequently used to study cellular biomechanics. In addition, the influence of various small-scale characteristics on common biomaterial surfaces for a range of different cell types is discussed.

  15. Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits.

    Science.gov (United States)

    Morel, Mathieu; Shtrahman, Roman; Rotter, Varda; Nissim, Lior; Bar-Ziv, Roy H

    2016-07-19

    Synthetic gene circuits are emerging as a versatile means to target cancer with enhanced specificity by combinatorial integration of multiple expression markers. Such circuits must also be tuned to be highly sensitive because escape of even a few cells might be detrimental. However, the error rates of decision-making circuits in light of cellular variability in gene expression have so far remained unexplored. Here, we measure the single-cell response function of a tunable logic AND gate acting on two promoters in heterogeneous cell populations. Our analysis reveals an inherent tradeoff between specificity and sensitivity that is controlled by the AND gate amplification gain and activation threshold. We implement a tumor-mimicking cell-culture model of cancer cells emerging in a background of normal ones, and show that molecular parameters of the synthetic circuits control specificity and sensitivity in a killing assay. This suggests that, beyond the inherent tradeoff, synthetic circuits operating in a heterogeneous environment could be optimized to efficiently target malignant state with minimal loss of specificity.

  16. International organizations as orchestrators

    CERN Document Server

    Abbott, Kenneth W

    2015-01-01

    International Organizations as Orchestrators reveals how IOs leverage their limited authority and resources to increase their effectiveness, power, and autonomy from states. By 'orchestrating' intermediaries - including NGOs - IOs can shape and steer global governance without engaging in hard, direct regulation. This volume is organized around a theoretical model that emphasizes voluntary collaboration and support. An outstanding group of scholars investigate the significance of orchestration across key issue areas, including trade, finance, environment and labor, and in leading organizations, including the GEF, G20, WTO, EU, Kimberley Process, UNEP and ILO. The empirical studies find that orchestration is pervasive. They broadly confirm the theoretical hypotheses while providing important new insights, especially that states often welcome IO orchestration as achieving governance without creating strong institutions. This volume changes our understanding of the relationships among IOs, nonstate actors and sta...

  17. Designing quantum-dot cellular automata circuits using a robust one layer crossover scheme

    Directory of Open Access Journals (Sweden)

    Sara Hashemi

    2014-04-01

    Full Text Available Quantum-dot cellular automata (QCA is a novel nanotechnology which is considered as a solution to the scaling problems in complementary metal oxide semiconductor technology. In this Letter, a robust one layer crossover scheme is introduced. It uses only 90° QCA cells and works based on a proper clock assignment. The application of this new scheme is shown in designing a sample QCA circuit. Simulation results demonstrate that using this new scheme, significant improvements in terms of area and complexity can be achieved.

  18. Orchestrator Telemetry Processing Pipeline

    Science.gov (United States)

    Powell, Mark; Mittman, David; Joswig, Joseph; Crockett, Thomas; Norris, Jeffrey

    2008-01-01

    Orchestrator is a software application infrastructure for telemetry monitoring, logging, processing, and distribution. The architecture has been applied to support operations of a variety of planetary rovers. Built in Java with the Eclipse Rich Client Platform, Orchestrator can run on most commonly used operating systems. The pipeline supports configurable parallel processing that can significantly reduce the time needed to process a large volume of data products. Processors in the pipeline implement a simple Java interface and declare their required input from upstream processors. Orchestrator is programmatically constructed by specifying a list of Java processor classes that are initiated at runtime to form the pipeline. Input dependencies are checked at runtime. Fault tolerance can be configured to attempt continuation of processing in the event of an error or failed input dependency if possible, or to abort further processing when an error is detected. This innovation also provides support for Java Message Service broadcasts of telemetry objects to clients and provides a file system and relational database logging of telemetry. Orchestrator supports remote monitoring and control of the pipeline using browser-based JMX controls and provides several integration paths for pre-compiled legacy data processors. At the time of this reporting, the Orchestrator architecture has been used by four NASA customers to build telemetry pipelines to support field operations. Example applications include high-volume stereo image capture and processing, simultaneous data monitoring and logging from multiple vehicles. Example telemetry processors used in field test operations support include vehicle position, attitude, articulation, GPS location, power, and stereo images.

  19. Identification of feedback loops embedded in cellular circuits by investigating non-causal impulse response components.

    Science.gov (United States)

    Dong, Chao-Yi; Yoon, Tae-Woong; Bates, Declan G; Cho, Kwang-Hyun

    2010-02-01

    Feedback circuits are crucial dynamic motifs which occur in many biomolecular regulatory networks. They play a pivotal role in the regulation and control of many important cellular processes such as gene transcription, signal transduction, and metabolism. In this study, we develop a novel computationally efficient method to identify feedback loops embedded in intracellular networks, which uses only time-series experimental data and requires no knowledge of the network structure. In the proposed approach, a non-parametric system identification technique, as well as a spectral factor analysis, is applied to derive a graphical criterion based on non-causal components of the system's impulse response. The appearance of non-causal components in the impulse response sequences arising from stochastic output perturbations is shown to imply the presence of underlying feedback connections within a linear network. In order to extend the approach to nonlinear networks, we linearize the intracellular networks about an equilibrium point, and then choose the magnitude of the output perturbations sufficiently small so that the resulting time-series responses remain close to the chosen equilibrium point. In this way, the impulse response sequences of the linearized system can be used to determine the presence or absence of feedback loops in the corresponding nonlinear network. The proposed method utilizes the time profile data from intracellular perturbation experiments and only requires the perturbability of output nodes. Most importantly, the method does not require any a priori knowledge of the system structure. For these reasons, the proposed approach is very well suited to identifying feedback loops in large-scale biomolecular networks. The effectiveness of the proposed method is illustrated via two examples: a synthetic network model with a negative feedback loop and a nonlinear caspase function model of apoptosis with a positive feedback loop.

  20. Orchestrating with Contracts

    DEFF Research Database (Denmark)

    Kiniry, Joseph Roland; Martinez, Josu

    2012-01-01

    Our domain of interest is self-healing systems. We wish to reason about the behavior of statically and dynamically composed systems. The orchestration language Orc permits one to write programs that compose such systems. Unfortunately, Orc's semantics make no assumptions about the behavior...... of the units under composition. Orc is an executable language, and in the Orc system, units are realized as methods implemented in the Java programming language. Since Java methods' behavior can be formally specified with the Java Modeling Language (JML), then the behavior of an Orc program can be reasoned...

  1. RNA assemblages orchestrate complex cellular processes

    DEFF Research Database (Denmark)

    Nielsen, Finn Cilius; Hansen, Heidi Theil; Christiansen, Jan

    2016-01-01

    Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid...... droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functionally related mRNAs. In a recent iCLIP study, we showed that the Drosophila RNA-binding protein Imp, which exhibits a C-terminal low-complexity sequence, increases the formation of F-actin by binding to 3......' untranslated regions of mRNAs encoding components participating in F-actin biogenesis. We hypothesize that phase transition is a mechanism the cell employs to increase the local mRNA concentration considerably, and in this way synchronize protein production in cytoplasmic territories, as discussed...

  2. Visualization and orchestration of the dynamic molecular society in cells

    Institute of Scientific and Technical Information of China (English)

    Xuebiao Yao; Guowei Fang

    2009-01-01

    @@ Visualization of specific molecules and their interactions in real space and time is essential to delineate how cellular plasticity and dynamics are achieved and orchestrated as perturbation of cellular plasticity and dynamics is detrimental to health. Elucidation of cellular dynamics requires molecular imaging at nanometer scale at millisecond resolution. The 1st International Conference on Cellular Dynamics and Chemical Biology held in Hefei, China (from 12 September to 15 September,2008) launched the quest by bringing synergism among photonics, chemistry and biology.

  3. Cellular Signaling Circuits Interfaced with Synthetic, Post-Translational, Negating Boolean Logic Devices

    Science.gov (United States)

    2014-01-01

    A negating functionality is fundamental to information processing of logic circuits within cells and computers. Aiming to adapt unutilized electronic concepts to the interrogation of signaling circuits in cells, we first took a bottom-up strategy whereby we created protein-based devices that perform negating Boolean logic operations such as NOT, NOR, NAND, and N-IMPLY. These devices function in living cells within a minute by precisely commanding the localization of an activator molecule among three subcellular spaces. We networked these synthetic gates to an endogenous signaling circuit and devised a physiological output. In search of logic functions in signal transduction, we next took a top–down approach and computationally screened 108 signaling pathways to identify commonalities and differences between these biological pathways and electronic circuits. This combination of synthetic and systems approaches will guide us in developing foundations for deconstruction of intricate cell signaling, as well as construction of biomolecular computers. PMID:25000210

  4. Optical imaging as a link between cellular neurophysiology and circuit modeling

    Directory of Open Access Journals (Sweden)

    Walther Akemann

    2009-07-01

    Full Text Available The relatively simple and highly modular circuitry of the cerebellum raised expectations decades ago that a realistic computational model of cerebellar circuit operations would be feasible, and prove insightful for unraveling cerebellar information processing. To this end, the biophysical properties of most cerebellar cell types and their synaptic connections have been well characterized and integrated into realistic single cell models. Furthermore, large scale models of cerebellar circuits that extrapolate from single cell properties to circuit dynamics have been constructed. While the development of single cell models have been constrained by microelectrode recordings, guidance and validation as these models are scaled up to study network interactions requires an experimental methodology capable of monitoring cerebellar dynamics at the population level. Here we review the potential of optical imaging techniques to serve this purpose.

  5. Algebraic circuits

    CERN Document Server

    Lloris Ruiz, Antonio; Parrilla Roure, Luis; García Ríos, Antonio

    2014-01-01

    This book presents a complete and accurate study of algebraic circuits, digital circuits whose performance can be associated with any algebraic structure. The authors distinguish between basic algebraic circuits, such as Linear Feedback Shift Registers (LFSRs) and cellular automata, and algebraic circuits, such as finite fields or Galois fields. The book includes a comprehensive review of representation systems, of arithmetic circuits implementing basic and more complex operations, and of the residue number systems (RNS). It presents a study of basic algebraic circuits such as LFSRs and cellular automata as well as a study of circuits related to Galois fields, including two real cryptographic applications of Galois fields.

  6. Cellular and circuit mechanisms maintain low spike co-variability and enhance population coding in somatosensory cortex

    Directory of Open Access Journals (Sweden)

    Cheng eLy

    2012-03-01

    Full Text Available The responses of cortical neurons are highly variable across repeated presentations of a stimulus. Understanding this variability is critical for theories of both sensory and motor processing, since response variance affects the accuracy of neural codes. Despite this influence, the cellular and circuit mechanisms that shape the trial-to-trial variability of population responses remain poorly understood. We used a combination of experimental and computational techniques to uncover the mechanisms underlying response variability of populations of pyramidal (E cells in layer 2/3 of rat whisker barrel cortex. Spike trains recorded from pairs of E-cells during either spontaneous activity or whisker deflected responses show similarly low levels of spiking co-variability, despite large differences in network activation between the two states. We developed network models that show how spike threshold nonlinearities dilutes E-cell spiking co-variability during spontaneous activity and low velocity whisker deflections. In contrast, during high velocity whisker deflections, cancelation mechanisms mediated by feedforward inhibition maintain low E-cell pairwise co-variability. Thus, the combination of these two mechanisms ensure low E-cell population variability over a wide range of whisker deflection velocities. Finally, we show how this active decorrelation of population variability leads to a drastic increase in the population information about whisker velocity. The canonical cellular and circuit components of our study suggest that low network variability over a broad range of neural states may generalize across the nervous system.

  7. Cellular and circuit mechanisms maintain low spike co-variability and enhance population coding in somatosensory cortex.

    Science.gov (United States)

    Ly, Cheng; Middleton, Jason W; Doiron, Brent

    2012-01-01

    The responses of cortical neurons are highly variable across repeated presentations of a stimulus. Understanding this variability is critical for theories of both sensory and motor processing, since response variance affects the accuracy of neural codes. Despite this influence, the cellular and circuit mechanisms that shape the trial-to-trial variability of population responses remain poorly understood. We used a combination of experimental and computational techniques to uncover the mechanisms underlying response variability of populations of pyramidal (E) cells in layer 2/3 of rat whisker barrel cortex. Spike trains recorded from pairs of E-cells during either spontaneous activity or whisker deflected responses show similarly low levels of spiking co-variability, despite large differences in network activation between the two states. We developed network models that show how spike threshold non-linearities dilute E-cell spiking co-variability during spontaneous activity and low velocity whisker deflections. In contrast, during high velocity whisker deflections, cancelation mechanisms mediated by feedforward inhibition maintain low E-cell pairwise co-variability. Thus, the combination of these two mechanisms ensure low E-cell population variability over a wide range of whisker deflection velocities. Finally, we show how this active decorrelation of population variability leads to a drastic increase in the population information about whisker velocity. The prevalence of spiking non-linearities and feedforward inhibition in the nervous system suggests that the mechanisms for low network variability presented in our study may generalize throughout the brain.

  8. Orchestral Performance and the Footprint of Mindfulness

    Science.gov (United States)

    Langer, Ellen; Russell, Timothy; Eisenkraft, Noah

    2009-01-01

    Two studies were designed to test the hypothesis that actively creating novel distinctions and sonically portraying them during the performance of orchestral music is preferable to attempting to re-create a past performance. The data suggest that orchestral musicians preferred creating music when they were encouraged to mindfully incorporate…

  9. Classroom orchestration : The third circle of usability

    OpenAIRE

    Dillenbourg, Pierre; Zufferey, Guillaume; Alavi, Hamed Seyed; Jermann, Patrick; Do, Lenh Hung Son; Bonnard, Quentin; Cuendet, Sébastien; Kaplan, Frédéric

    2011-01-01

    We analyze classroom orchestration as a question of usability in which the classroom is the user. Our experiments revealed design features that reduce the global orchestration load. According to our studies in vocational schools, paper-based interfaces have the potential of making educational workflows tangible, i.e. both visible and manipulable. Our studies in university classes converge on minimalism: they reveal the effectiveness o tools that make visible what is invisible but do not analy...

  10. Optimizing Decisions in Web Services Orchestrations

    OpenAIRE

    Kattepur, Ajay; Benveniste, Albert; Jard, Claude

    2011-01-01

    International audience; Web services orchestrations conventionally employ exhaustive comparison of runtime quality of service (QoS) metrics for decision making. The ability to incorporate more complex mathematical packages are needed, especially in case of workflows for resource allocation and queuing systems. By modeling such optimization routines as service calls within orchestration specifications, techniques such as linear programming can be conveniently invoked by non-specialist workflow...

  11. The RichWPS Environment for Orchestration

    Directory of Open Access Journals (Sweden)

    Felix Bensmann

    2014-12-01

    Full Text Available Web service (WS orchestration can be considered as a fundamental concept in service-oriented architectures (SOA, as well as in spatial data infrastructures (SDI. In recent years in SOA, advanced solutions were developed, such as realizing orchestrated web services on the basis of already existing more fine-granular web services by using standardized notations and existing orchestration engines. Even if the concepts can be mapped to the field of SDI, on a conceptual level the implementations target different goals. As a specialized form of a common web service, an Open Geospatial Consortium (OGC web service (OWS is optimized for a specific purpose. On the technological level, web services depend on standards like the Web Service Description Language (WSDL or the Simple Object Access Protocol (SOAP. However OWS are different. Consequently, a new concept for OWS orchestration is needed that works on the interface provided by OWS. Such a concept is presented in this work. The major component is an orchestration engine integrated in a Web Processing Service (WPS server that uses a domain specific language (DSL for workflow description. The developed concept is the base for the realization of new functionality, such as workflow testing, and workflow optimization.

  12. WOX5-1AA17 Feedback Circuit-Mediated CellularAuxin Response Is Crucial for the Patterning ofRoot Stem Cell Niches in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    In plants, the patterning of stem cell-enriched meristems requires a graded auxin response maximum thatemerges from the concerted action of polar auxin transport, auxin biosynthesis, auxin metabolism, and cellular auxinresponse machinery. However, mechanisms underlying this auxin response maximum-mediated root stem cell mainte-nance are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED HOMEOBOX 5 (WOX5)transcription factor modulates expression of auxin biosynthetic genes in the quiescent center (QC) of the root and thusprovides a robust mechanism for the maintenance of auxin response maximum in the root tip. This WOX5 action is bal-anced through the activity of indole-3-acetic acid 17 (IAA17) auxin response repressor. Our combined genetic, cell biol-ogy, and computational modeling studies revealed a previously uncharacterized feedback loop linking WOX5-mediatedauxin production to IAA17-dependent repression of auxin responses. This WOX5-1AA17 feedback circuit further assuresthe maintenance of auxin response maximum in the root tip and thereby contributes to the maintenance of distal stemcell (DSC) populations. Our experimental studies and in silico computer simulations both demonstrate that the WOX5-iAA17 feedback circuit is essential for the maintenance of auxin gradient in the root tip and the auxin-mediated root DSCdifferentiation.

  13. Metric-Aware Secure Service Orchestration

    Directory of Open Access Journals (Sweden)

    Gabriele Costa

    2012-12-01

    Full Text Available Secure orchestration is an important concern in the internet of service. Next to providing the required functionality the composite services must also provide a reasonable level of security in order to protect sensitive data. Thus, the orchestrator has a need to check whether the complex service is able to satisfy certain properties. Some properties are expressed with metrics for precise definition of requirements. Thus, the problem is to analyse the values of metrics for a complex business process. In this paper we extend our previous work on analysis of secure orchestration with quantifiable properties. We show how to define, verify and enforce quantitative security requirements in one framework with other security properties. The proposed approach should help to select the most suitable service architecture and guarantee fulfilment of the declared security requirements.

  14. Russian orchestral works. Torgny Sporsen / Ivan March

    Index Scriptorium Estoniae

    March, Ivan

    1991-01-01

    Uuest heliplaadist "Russian orchestral works. Torgny Sporsen (bass). Gothenburg Symphony Brass Band. Gothenburg Symphony Chorus and Orchestra / Neeme Järvi" D6 MC 429 984 - 4 GH; CD 429 984 - 26H (76 minutes). Borodin: In Central Asia. Prince Igor - Polovtsian Dances

  15. Dynamic System Adaptation by Constraint Orchestration

    CERN Document Server

    Groenewegen, L P J

    2008-01-01

    For Paradigm models, evolution is just-in-time specified coordination conducted by a special reusable component McPal. Evolution can be treated consistently and on-the-fly through Paradigm's constraint orchestration, also for originally unforeseen evolution. UML-like diagrams visually supplement such migration, as is illustrated for the case of a critical section solution evolving into a pipeline architecture.

  16. Microsoft System Center 2012 Orchestrator cookbook

    CERN Document Server

    Erskine, Samuel

    2013-01-01

    This book is written in a practical, Cookbook style with numerous chapters and recipes focusing on creating runbooks to automate mission critical and everyday administration tasks.System Center 2012 Orchestrator is for administrators who wish to simplify the process of automating systems administration tasks. This book assumes that you have a basic knowledge of Windows Server 2008 Administration, Active Directory, Network Systems, and Microsoft System Center technologies.

  17. 量子元胞自动机器件和电路的研究进展%Research Progress of Quantum Dot Cellular Automata Devices and Circuits

    Institute of Scientific and Technical Information of China (English)

    杨晓阔; 蔡理; 李政操; 陈祥叶

    2011-01-01

    Quantum dot cellular automata (QCA) is a novel nanotechnology, the information of QCA is calculated and transferred not by the voltage or current, but by the field interaction. The computation principles, basic logic gates and clockings of two kinds of QCA (EQCA and MQCA) devices are introduced firstly. It shows that different wire structures comprised of QCA cells could realize planar crossover and transmit signals in a single layer independently. Furthermore, the experiment methods and materials to fabricate QCA devices and function arrays or circuits are summarized, and the conclusion is obtained that the development of MQCA and molecular EQCA devices would bring QCA up to the actual application level gradually. The research progresses and existent issues of QCA devices and circuits (particularly memory cell architecture) are discussed in detail. The open projects and directions in theory and application research of QCA are presented.%量子元胞自动机(QCA)是一种新颖的纳米技术,该技术不再通过电流或电压而是基于场相互作用进行信息的计算和传递.首先,综述了两种量子元胞自动机(EQCA和MQCA)器件的计算原理、基本逻辑门和时钟.指出了QCA元胞构成的不同线结构可在相同层交叉传递信号而不受影响.然后,进一步总结了制备QCA器件和功能阵列或电路的实验方法和材料,得出MQCA器件和分子EQCA器件的发展将使该器件逐步达到实际应用水平的结论.详细讨论了目前QCA器件和电路(尤其是存储单元结构)研究取得的重要进展以及面临的问题.提出了QCA器件未来理论和应用研究中的开放课题和方向.

  18. Meteorological phenomena in Western classical orchestral music

    Science.gov (United States)

    Williams, P. D.; Aplin, K. L.

    2012-12-01

    The creative output of composers, writers, and artists is often influenced by their surroundings. To give a literary example, it has been claimed recently that some of the characters in Oliver Twist and A Christmas Carol were based on real-life people who lived near Charles Dickens in London. Of course, an important part of what we see and hear is not only the people with whom we interact, but also our geophysical surroundings. Of all the geophysical phenomena to influence us, the weather is arguably the most significant, because we are exposed to it directly and daily. The weather was a great source of inspiration for Monet, Constable, and Turner, who are known for their scientifically accurate paintings of the skies. But to what extent does weather inspire composers? The authors of this presentation, who are atmospheric scientists by day but amateur classical musicians by night, have been contemplating this question. We have built a systematic musical database, which has allowed us to catalogue and analyze the frequencies with which weather is depicted in a sample of classical orchestral music. The depictions vary from explicit mimicry using traditional and specialized orchestral instruments, through to subtle suggestions. We have found that composers are generally influenced by their own environment in the type of weather they choose to represent. As befits the national stereotype, British composers seem disproportionately keen to depict the UK's variable weather patterns and stormy coastline. Reference: Aplin KL and Williams PD (2011) Meteorological phenomena in Western classical orchestral music. Weather, 66(11), pp 300-306. doi:10.1002/wea.765

  19. Musical acoustics of orchestral water crotales.

    Science.gov (United States)

    Worland, Randy

    2012-01-01

    An experimental investigation of orchestral crotale vibrational modes in water is presented, along with a qualitative virtual mass model describing the observed effects. Changes in frequency, overtone ratio, and mode splitting as a function of water depth are reported for a C(6) crotale using electronic speckle-pattern interferometry. These data are related to perceived changes in pitch and timbre, along with the creation of audible beats at particular water depths. It is also shown that the suspension method used by musicians when dipping crotales into water leads to the creation of additional acoustically significant modes that are not excited when the crotales are mounted in the standard manner.

  20. From Orchestration to Choreography through Contract Automata

    Directory of Open Access Journals (Sweden)

    Davide Basile

    2014-10-01

    Full Text Available We study the relations between a contract automata and an interaction model. In the former model, distributed services are abstracted away as automata - oblivious of their partners - that coordinate with each other through an orchestrator. The interaction model relies on channel-based asynchronous communication and choreography to coordinate distributed services. We define a notion of strong agreement on the contract model, exhibit a natural mapping from the contract model to the interaction model, and give conditions to ensure that strong agreement corresponds to well-formed choreography.

  1. Endocrine orchestration of cardiovascular, gastrointestinal and hypothalamic control.

    Science.gov (United States)

    Angelone, T; Quintieri, A M; Amodio, N; Cerra, M C

    2011-01-01

    The richly structured neuroendocrine control of the heart in health and disease requires, in addition to the autonomic nervous outflow, the essential contribute of various and often interacting humoral peptides (e.g. natriuretic peptides, Chromogranin-A-derived fragments, etc). In many cases, these molecules also influence the activity of other organ systems, including the gastrointestinal apparatus, in which they control mucosal function as well as motility and secretion. Interestingly, by acting centrally, some of these peptides also regulate satiety and appetite, thus forming an interesting link between cardiac and gastrointestinal function, and the feeding pattern. Prolonged inhibition and/or activation of these peptide pathways frequently results in severe and long-lasting dysfunctions, including cardiovascular diseases associated to alimentary disorders (e.g. obesity). Notably, their multifarious actions and mutual interactions make them excellent candidates for long-term resetting of both cardiac, gastrointestinal and nutrition homeostasis. Here we will provide only few examples taken from the quickly evolving scenario, with the purpose to provide indications concerning the complex circuits generated by multilevel signalling peptides, which contributes to orchestrate the association between cardiovascular, gastrointestinal and alimentary functions. This will highlight not only the complexity of the cardiovascular and GI regulatory networks, but also aspects of integration between feeding stimulating peptides and the other neuroendocrine systems affecting the heart and the GI tract.

  2. Service Orchestration on the Internet of Things

    Directory of Open Access Journals (Sweden)

    Jordán Pascual Espada

    2012-12-01

    Full Text Available On July 27, 2010, Jordán Pascual Espada defended his Master’s thesis at Oviedo University (Spain, titled: “Service Orchestration on the internet of things”. This Master’s thesis is the final part of the Web Engineering Official Research Master belonging to the European Higher Education Area. Jordán Pascual Espada defended his dissertation in a publicly open presentation held in the School of Computer Engineering at Oviedo University, and was able to comment on every question raised by his committee and the audience. The master’s thesis was supervised by his advisors, Juan Manuel Cueva Lovelle and Oscar Sanjuán Martínez. The thesis has been read and approved by his thesis committee, receiving the highest rating.

  3. The Neuronal Network Orchestration behind Motor Behaviors

    DEFF Research Database (Denmark)

    Petersen, Peter Christian

    In biological networks, millions of neurons organize themselves from microscopic noisy individuals to robust macroscopic entities. These entities are capable of producing higher functions like sensory processing, decision-making, and elaborate behavioral responses. Every aspect of these behaviors...... is the outcome of an advanced orchestration of the activity of populations of neurons. Through spiking activity, neurons are able to interact; yet we know little about how this interaction occurs in spinal networks. How is the activity distributed across the population? What is the composition of synaptic input...... that is received by the individual neurons and how is the synaptic input processed? This thesis focuses on aspects of these questions for spinal networks involved in the generation of stereotypical motor behaviors. The thesis consists of two studies. In the first study, I investigated the synaptic input...

  4. Orchestrating Transnational Environmental Governance in Maritime Shipping

    DEFF Research Database (Denmark)

    Lister, Jane; Taudal Poulsen, René; Ponte, Stefano

    2015-01-01

    —the International Maritime Organization. Drawing on original empirical evidence and archival data, we introduce a four-factor framework to investigate two main questions: why is shipping lagging in its environmental governance; and what is the potential for the International Maritime Organization to orchestrate...... emerging private ‘green shipping’ initiatives to achieve better ecological outcomes? Contributing to transnational governance theory, we find that conditions stalling regulatory progress include low environmental issue visibility, poor interest alignment, a broadening scope of environmental issues......Maritime shipping is the transmission belt of the global economy. It is also a major contributor to global environmental change through its under-regulated air, water and land impacts. It is puzzling that shipping is a lagging sector as it has a well-established global regulatory body...

  5. Orchestration of Social Modes in e-Learning

    DEFF Research Database (Denmark)

    Weinberger, Armin; Papadopoulos, Pantelis M.

    2016-01-01

    of tools offering possibilities to the teachers, orchestration refers to the purposeful mixture of different aspects of the learning experience, serving a particular set of learning goals. In this paper, we present the current dialogue on e-learning orchestration, identifying the questions and open issues...

  6. An Exploratory Comparison of Novice, Intermediate, and Expert Orchestral Conductors

    Science.gov (United States)

    Bergee, Martin J.

    2005-01-01

    This study compared novice, "intermediate" (graduate student), and expert orchestral conductors. Two novice conductors, one graduate student in orchestral conducting, and one expert conductor led a university symphony orchestra in part of the first movement of Brahms's Symphony No. 2. Wired for sound, conductors attempted to verbalize their…

  7. Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture.

    Science.gov (United States)

    Malenczyk, Katarzyna; Keimpema, Erik; Piscitelli, Fabiana; Calvigioni, Daniela; Björklund, Peyman; Mackie, Kenneth; Di Marzo, Vincenzo; Hökfelt, Tomas G M; Dobrzyn, Agnieszka; Harkany, Tibor

    2015-11-10

    Endocannabinoids are implicated in the control of glucose utilization and energy homeostasis by orchestrating pancreatic hormone release. Moreover, in some cell niches, endocannabinoids regulate cell proliferation, fate determination, and migration. Nevertheless, endocannabinoid contributions to the development of the endocrine pancreas remain unknown. Here, we show that α cells produce the endocannabinoid 2-arachidonoylglycerol (2-AG) in mouse fetuses and human pancreatic islets, which primes the recruitment of β cells by CB1 cannabinoid receptor (CB1R) engagement. Using subtractive pharmacology, we extend these findings to anandamide, a promiscuous endocannabinoid/endovanilloid ligand, which impacts both the determination of islet size by cell proliferation and α/β cell sorting by differential activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) and CB1Rs. Accordingly, genetic disruption of TRPV1 channels increases islet size whereas CB1R knockout augments cellular heterogeneity and favors insulin over glucagon release. Dietary enrichment in ω-3 fatty acids during pregnancy and lactation in mice, which permanently reduces endocannabinoid levels in the offspring, phenocopies CB1R(-/-) islet microstructure and improves coordinated hormone secretion. Overall, our data mechanistically link endocannabinoids to cell proliferation and sorting during pancreatic islet formation, as well as to life-long programming of hormonal determinants of glucose homeostasis.

  8. Orchestrating Distributed Resource Ensembles for Petascale Science

    Energy Technology Data Exchange (ETDEWEB)

    Baldin, Ilya; Mandal, Anirban; Ruth, Paul; Yufeng, Xin

    2014-04-24

    Distributed, data-intensive computational science applications of interest to DOE scientific com- munities move large amounts of data for experiment data management, distributed analysis steps, remote visualization, and accessing scientific instruments. These applications need to orchestrate ensembles of resources from multiple resource pools and interconnect them with high-capacity multi- layered networks across multiple domains. It is highly desirable that mechanisms are designed that provide this type of resource provisioning capability to a broad class of applications. It is also important to have coherent monitoring capabilities for such complex distributed environments. In this project, we addressed these problems by designing an abstract API, enabled by novel semantic resource descriptions, for provisioning complex and heterogeneous resources from multiple providers using their native provisioning mechanisms and control planes: computational, storage, and multi-layered high-speed network domains. We used an extensible resource representation based on semantic web technologies to afford maximum flexibility to applications in specifying their needs. We evaluated the effectiveness of provisioning using representative data-intensive ap- plications. We also developed mechanisms for providing feedback about resource performance to the application, to enable closed-loop feedback control and dynamic adjustments to resource allo- cations (elasticity). This was enabled through development of a novel persistent query framework that consumes disparate sources of monitoring data, including perfSONAR, and provides scalable distribution of asynchronous notifications.

  9. Orchestration of angiogenesis by immune cells

    Directory of Open Access Journals (Sweden)

    Antonino eBruno

    2014-07-01

    Full Text Available It is widely accepted that the tumor microenvironment plays a major role in cancer and is indispensable for tumor progression. The tumor microenvironment involves many players going well beyond the malignant-transformed cells, including stromal, immune and endothelial cells. The non-malignant cells can acquire tumor-promoting functions during carcinogenesis. In particular, these cells can orchestrate the symphony of the angiogenic switch, permitting the creation of new blood vessels that allows rapid expansion and progression toward malignancy.Considerable attention within the context of tumor angiogenesis should focus not only on the endothelial cells, representing a fundamental unit, but also on immune cells and on the inflammatory tumor infiltrate. Immune cells infiltrating tumors typically show a tumor-induced polarization associated with attenuation of anti-tumor functions and generation of pro-tumor activities, among these angiogenesis. Here we propose a scenario suggesting that the angiogenic switch is an immune switch arising from the pro-angiogenic polarization of immune cells. This view links immunity, inflammation and angiogenesis to tumor progression. Here we review the data in the literature and seek to identify the conductors of this orchestra. We also suggest that interrupting the immune -> inflammation -> angiogenesis -> tumor progression process can delay or prevent tumor insurgence and malignant disease.

  10. Optimization of Orchestral Layouts Based on Instrument Directivity Patterns

    Science.gov (United States)

    Stroud, Nathan Paul

    The experience of hearing an exceptional symphony orchestra perform in an excel- lent concert hall can be profound and moving, causing a level of excitement not often reached for listeners. Romantic period style orchestral music, recognized for validating the use of intense emotion for aesthetic pleasure, was the last significant development in the history of the orchestra. In an age where orchestral popularity is waning, the possibil- ity of evolving the orchestral sound in our modern era exists through the combination of our current understanding of instrument directivity patterns and their interaction with architectural acoustics. With the aid of wave field synthesis (WFS), newly proposed variations on orchestral layouts are tested virtually using a 64-channel WFS array. Each layout is objectively and subjectively compared for determination of which layout could optimize the sound of the orchestra and revitalize the excitement of the performance.

  11. Tchaikovsky, P.: Orchestral Suite no. 3 op. 55 / Terry Williams

    Index Scriptorium Estoniae

    Williams, Terry

    1996-01-01

    Uuest heliplaadist "Tchaikovsky, P.: Orchestral Suite no. 3 op. 55. Francesca di Rimini op. 32. Detroit Symphony Orchestra, Neeme Järvi". Chandos CHAN 9 419, distribution Media 7 (CD: 160F). TT: 1h 09'20"

  12. Sound exposure of professional orchestral musicians during solitary practice.

    Science.gov (United States)

    O'Brien, Ian; Driscoll, Tim; Ackermann, Bronwen

    2013-10-01

    It is broadly acknowledged that professional orchestral musicians risk noise-induced hearing pathologies due to sound exposure in rehearsal and performance. While much has been published regarding orchestral sound levels, little is known of the sound exposure these musicians experience during solitary practice, despite the many hours they spend engaged in this activity. This study aimed to determine sound exposure during solitary practice of 35 professional orchestral musicians, representing players of most orchestral instruments. To allow cross-comparison, participants were assessed playing similar repertoire in a controlled environment, recording simultaneously at each ear to determine sound exposure levels. Sound levels were recorded between 60 and 107 dB L(Aeq), with peak levels between 101 and 130 dB L(C,peak). For average reported practice durations (2.1 h per day, five days a week) 53% would exceed accepted permissible daily noise exposure in solitary practice, in addition to sound exposure during orchestral rehearsals and performances. Significant inter-aural differences were noted in violin, viola, flute/piccolo, horn, trombone, and tuba. Only 40% used hearing protection at any time while practicing. These findings indicate orchestral musicians at risk of noise-induced hearing loss in ensemble face significant additional risks during solitary practice. Data presented will enable more effective and targeted management strategies for this population.

  13. Approaches to Learning and Study Orchestrations in High School Students

    Science.gov (United States)

    Cano, Francisco

    2007-01-01

    In the framework of the SAL (Students' approaches to learning) position, the learning experience (approaches to learning and study orchestrations) of 572 high school students was explored, examining its interrelationships with some personal and familial variables. Three major results emerged. First, links were found between family's intellectual…

  14. Logistics orchestration scenarios in a potted plant supply chain network

    NARCIS (Netherlands)

    Keizer, de M.; Groot, J.J.; Bloemhof, J.M.; Vorst, van der J.G.A.J.

    2014-01-01

    The Dutch potted plant sector has a dominant international position, but new marketing channels and emerging markets on distance call for new logistics concepts. This paper explores the potential of an advanced logistics concept, i.e. logistics orchestration, that aims for improved collaboration bet

  15. Pärt: Chamber and Orchestral Works / Robert Cowan

    Index Scriptorium Estoniae

    Cowan, Robert

    1994-01-01

    Uuest heliplaadist "Pärt: Chamber and Orchestral Works. Bournemouth Sinfonietta, Richard Studt. EMI Eminence CD CD-EMX 2221; Fratres; Cantus in memory of Benjamin Britten; Summa; Spiegel im Spiegel; Festina lente; Tabula Rasa; Fratres - selected comparison: Bachmann, Kibonoff (12/94)(CATA) 09026 61824-2. Kremer, Jarrett (ECM) 817 764-2

  16. Roles of Teachers in Orchestrating Learning in Elementary Science Classrooms

    Science.gov (United States)

    Zhai, Junqing; Tan, Aik-Ling

    2015-01-01

    This study delves into the different roles that elementary science teachers play in the classroom to orchestrate science learning opportunities for students. Examining the classroom practices of three elementary science teachers in Singapore, we found that teachers shuttle between four key roles in enabling student learning in science. Teachers…

  17. Score-Informed Source Separation for Multichannel Orchestral Recordings

    Directory of Open Access Journals (Sweden)

    Marius Miron

    2016-01-01

    Full Text Available This paper proposes a system for score-informed audio source separation for multichannel orchestral recordings. The orchestral music repertoire relies on the existence of scores. Thus, a reliable separation requires a good alignment of the score with the audio of the performance. To that extent, automatic score alignment methods are reliable when allowing a tolerance window around the actual onset and offset. Moreover, several factors increase the difficulty of our task: a high reverberant image, large ensembles having rich polyphony, and a large variety of instruments recorded within a distant-microphone setup. To solve these problems, we design context-specific methods such as the refinement of score-following output in order to obtain a more precise alignment. Moreover, we extend a close-microphone separation framework to deal with the distant-microphone orchestral recordings. Then, we propose the first open evaluation dataset in this musical context, including annotations of the notes played by multiple instruments from an orchestral ensemble. The evaluation aims at analyzing the interactions of important parts of the separation framework on the quality of separation. Results show that we are able to align the original score with the audio of the performance and separate the sources corresponding to the instrument sections.

  18. Shostakovich: The Orchestral Songs Vol. 2 / Michael Tanner

    Index Scriptorium Estoniae

    Tanner, Michael

    1996-01-01

    Uuest heliplaadist "Shostakovich: The Orchestral Songs Vol. 2: Six Romances on texts by Japanese poets, Op. 21. Six Poems on Marina Tsvetayeva, Op. 143. Suite on Verses of Michelangelo, Op. 145. Gothenburg Symphony Orchestra, Neeme Järvi". DG 447 085-2GH (71 minutes:DDD)

  19. Orchestration in Learning Technology Research: Evaluation of a Conceptual Framework

    Science.gov (United States)

    Prieto, Luis P.; Dimitriadis, Yannis; Asensio-Pérez, Juan I.; Looi, Chee-Kit

    2015-01-01

    The term "orchestrating learning" is being used increasingly often, referring to the coordination activities performed while applying learning technologies to authentic settings. However, there is little consensus about how this notion should be conceptualised, and what aspects it entails. In this paper, a conceptual framework for…

  20. Orchestrating Masses of Sensors; A Design-Driven Development Approach

    OpenAIRE

    Kabáč, Milan; Consel, Charles

    2015-01-01

    International audience; This paper proposes a design-driven development approach that is dedicated to the domain of orchestration of masses of sensors. The developer declares what an application does using a domain-specific language (DSL). Our compiler processes domain-specific declarations to generate a customized programming framework that guides and supports the programming phase.

  1. Melatonin--a pleiotropic, orchestrating regulator molecule.

    Science.gov (United States)

    Hardeland, Rüdiger; Cardinali, Daniel P; Srinivasan, Venkatramanujam; Spence, D Warren; Brown, Gregory M; Pandi-Perumal, Seithikurippu R

    2011-03-01

    Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis.

  2. Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses.

    Science.gov (United States)

    Soares, Helena; Lasserre, Rémi; Alcover, Andrés

    2013-11-01

    Immunological synapses are specialized cell-cell contacts formed between T lymphocytes and antigen-presenting cells. They are induced upon antigen recognition and are crucial for T-cell activation and effector functions. The generation and function of immunological synapses depend on an active T-cell polarization process, which results from a finely orchestrated crosstalk between the antigen receptor signal transduction machinery, the actin and microtubule cytoskeletons, and controlled vesicle traffic. Although we understand how some of these particular events are regulated, we still lack knowledge on how these multiple cellular elements are harmonized to ensure appropriate T-cell responses. We discuss here our view on how T-cell receptor signal transduction initially commands cytoskeletal and vesicle traffic polarization, which in turn sets the immunological synapse molecular design that regulates T-cell activation. We also discuss how the human immunodeficiency virus (HIV-1) hijacks some of these processes impairing immunological synapse generation and function.

  3. Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response

    Institute of Scientific and Technical Information of China (English)

    Weiming XU; Ian G. CHARLES; Salvador MONCADA

    2005-01-01

    Mitochondria have long been considered to be the powerhouse of the living cell, generating energy in the form of the molecule ATP via the process of oxidative phosphorylation. In the past 20 years, it has been recognised that they also play an important role in the implementation of apoptosis, or programmed cell death. More recently it has become evident that mitochondria also participate in the orchestration of cellular defence responses. At physiological concentrations,the gaseous molecule nitric oxide (NO) inhibits the mitochondrial enzyme cytochrome c oxidase (complex IV) in competition with oxygen. This interaction underlies the mitochondrial actions of NO, which range from the physiological regulation of cell respiration, through mitochondrial signalling, to the development of "metabolic hypoxia" - a situation in which, although oxygen is available, the cell is unable to utilise it.

  4. Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks

    Science.gov (United States)

    Torcini, Alessandro; Luccioli, Stefano; Bonifazi, Paolo; Ben-Jacob, Eshel; Barzilai, Ari

    2015-03-01

    It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in developing neuronal circuits, typically composed of only excitatory cells, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally regulated constraints on single neuron excitability and connectivity leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity. This work is part of the activity of the Joint Italian-Israeli Laboratory on Integrative Network Neuroscience supported by the Italian Ministry of Foreign Affairs.

  5. Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.

    Directory of Open Access Journals (Sweden)

    Stefano Luccioli

    2014-09-01

    Full Text Available It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.

  6. Specifying Orchestrating Capability in Network Organization and Interfirm Innovation Networks

    DEFF Research Database (Denmark)

    Hu, Yimei; Sørensen, Olav Jull

    implements its blue ocean strategy through purposively build multi-level networks, i.e. an intra network organization and interfirm innovation networks. In order to get more innovation output from external and internal networks, orchestration capability is needed and should be applied both externally......Open innovation in interfirm networks has been a popular topic for long, and the focal firm with orchestration capability will enhance its innovation performance through networks. However, only recently, researchers started to study SME’s open innovation and networks, especially those from the low......-tech industry. Besides interfirm networks, some organizational researchers are interested in the internal network organizational design. Prospector firms putting innovation on top of the agenda usually has a network organization which is more flexible. This paper analyzes how an SME from a traditional industry...

  7. Introduction to Devices Orchestration in Internet of Things Using SBPMN

    Directory of Open Access Journals (Sweden)

    Alejandro González García

    2011-12-01

    Full Text Available In this research we try to provide an architecture that allows the orchestration of objects that are part of the Internet of things creating business processes. Internet of Things is still in full development; this implies that there is a lack of standards for its proper implementation. Among these gaps is for example the technology used to allow objects to connect to the network, since there are several options but none seems to end imposed that is why this work try to provide architecture that imposes an alternative solution to this problem. However, it is difficult to provide a common solution to all the objects used in everyday life because of its great diversity, it requires us to classify them and thus create an appropriate architecture for each of the types These architectures are designed to facilitate the devices orchestration in a similar way as is currently done with web services enabling business process modeling.

  8. Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm.

    Science.gov (United States)

    Covarrubias, Sergio; Richner, Justin M; Clyde, Karen; Lee, Yeon J; Glaunsinger, Britt A

    2009-09-01

    Lytic infection with the two human gammaherpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), leads to significant depletion of the cellular transcriptome. This host shutoff phenotype is driven by the conserved herpesviral alkaline exonuclease, termed SOX in KSHV and BGLF5 in EBV, which in gammaherpesviruses has evolved the genetically separable ability to target cellular mRNA. We now show that host shutoff is also a prominent consequence of murine gammaherpesvirus 68 (MHV68) infection, which is widely used as a model system to study pathogenesis of these viruses in vivo. The effector of MHV68-induced host shutoff is its SOX homolog, here termed muSOX. There is remarkable functional conservation of muSOX host shutoff activities with those of KSHV SOX, including the recently described ability of SOX to induce mRNA hyperadenylation in the nucleus as well as cause nuclear relocalization of the poly(A) binding protein. SOX and muSOX localize to both the nucleus and cytoplasm of infected cells. Using spatially restricted variants of these proteins, we go on to demonstrate that all known host shutoff-related activities of SOX and muSOX are orchestrated exclusively from the cytoplasm. These results have important mechanistic implications for how SOX and muSOX target nascent cellular transcripts in the nucleus. Furthermore, our findings establish MHV68 as a new, genetically tractable model to study host shutoff.

  9. Orchestration Framework for Learning Activities in Augmented Reality Environments

    OpenAIRE

    Ibáñez, María Blanca; Delgado Kloos, Carlos; Di Serio, Angela

    2011-01-01

    Proceedings of: Across Spaces11 Workshop in conjunction with the EC-TEL2011, Palermo, Italy, September 21, 2011 In this paper we show how Augmented Reality (AR) technology restricted to the use of mobiles or PCs, can be used to develop learning activities with the minimun level of orchestation required by meaningful learning sequences. We use Popcode as programming language to deploy orchestrated learning activities specified with an AR framework. Publicado

  10. Resonance circuits for adiabatic circuits

    Directory of Open Access Journals (Sweden)

    C. Schlachta

    2003-01-01

    Full Text Available One of the possible techniques to reduces the power consumption in digital CMOS circuits is to slow down the charge transport. This slowdown can be achieved by introducing an inductor in the charging path. Additionally, the inductor can act as an energy storage element, conserving the energy that is normally dissipated during discharging. Together with the parasitic capacitances from the circuit a LCresonant circuit is formed.

  11. GATING CIRCUITS

    Science.gov (United States)

    Merrill, L.C.

    1958-10-14

    Control circuits for vacuum tubes are described, and a binary counter having an improved trigger circuit is reported. The salient feature of the binary counter is the application of the input signal to the cathode of each of two vacuum tubes through separate capacitors and the connection of each cathode to ground through separate diodes. The control of the binary counter is achieved in this manner without special pulse shaping of the input signal. A further advantage of the circuit is the simplicity and minimum nuruber of components required, making its use particularly desirable in computer machines.

  12. TRIO: Burst Buffer Based I/O Orchestration

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Teng [Auburn University; Oral, H Sarp [ORNL; Pritchard, Michael [Auburn University; Wang, Bin [Auburn University; Yu, Weikuan [Auburn University

    2015-01-01

    The growing computing power on leadership HPC systems is often accompanied by ever-escalating failure rates. Checkpointing is a common defensive mechanism used by scientific applications for failure recovery. However, directly writing the large and bursty checkpointing dataset to parallel filesystem can incur significant I/O contention on storage servers. Such contention in turn degrades the raw bandwidth utilization of storage servers and prolongs the average job I/O time of concurrent applications. Recently burst buffer has been proposed as an intermediate layer to absorb the bursty I/O traffic from compute nodes to storage backend. But an I/O orchestration mechanism is still desired to efficiently move checkpointing data from bursty buffers to storage backend. In this paper, we propose a burst buffer based I/O orchestration framework, named TRIO, to intercept and reshape the bursty writes for better sequential write traffic to storage severs. Meanwhile, TRIO coordinates the flushing orders among concurrent burst buffers to alleviate the contention on storage server bandwidth. Our experimental results reveal that TRIO can deliver 30.5% higher bandwidth and reduce the average job I/O time by 37% on average for data-intensive applications in various checkpointing scenarios.

  13. A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis.

    Science.gov (United States)

    Tawk, Marcel; Araya, Claudio; Lyons, Dave A; Reugels, Alexander M; Girdler, Gemma C; Bayley, Philippa R; Hyde, David R; Tada, Masazumi; Clarke, Jonathan D W

    2007-04-12

    The development of cell polarity is an essential prerequisite for tissue morphogenesis during embryogenesis, particularly in the development of epithelia. In addition, oriented cell division can have a powerful influence on tissue morphogenesis. Here we identify a novel mode of polarized cell division that generates pairs of neural progenitors with mirror-symmetric polarity in the developing zebrafish neural tube and has dramatic consequences for the organization of embryonic tissue. We show that during neural rod formation the polarity protein Pard3 is localized to the cleavage furrow of dividing progenitors, and then mirror-symmetrically inherited by the two daughter cells. This allows the daughter cells to integrate into opposite sides of the developing neural tube. Furthermore, these mirror-symmetric divisions have powerful morphogenetic influence: when forced to occur in ectopic locations during neurulation, they orchestrate the development of mirror-image pattern formation and the consequent generation of ectopic neural tubes.

  14. Programming Cloud Resource Orchestration Framework: Operations and Research Challenges

    CERN Document Server

    Ranjan, Rajiv

    2012-01-01

    The emergence of cloud computing over the past five years is potentially one of the breakthrough advances in the history of computing. It delivers hardware and software resources as virtualization-enabled services and in which administrators are free from the burden of worrying about the low level implementation or system administration details. Although cloud computing offers considerable opportunities for the users (e.g. application developers, governments, new startups, administrators, consultants, scientists, business analyst, etc.) such as no up-front investment, lowering operating cost, and infinite scalability, it has many unique research challenges that need to be carefully addressed in the future. In this paper, we present a survey on key cloud computing concepts, resource abstractions, and programming operations for orchestrating resources and associated research challenges, wherever applicable.

  15. Orchestrating learning during implementation of a 3D virtual world

    Science.gov (United States)

    Karakus, Turkan; Baydas, Ozlem; Gunay, Fatma; Coban, Murat; Goktas, Yuksel

    2016-10-01

    There are many issues to be considered when designing virtual worlds for educational purposes. In this study, the term orchestration has acquired a new definition as the moderation of problems encountered during the activity of turning a virtual world into an educational setting for winter sports. A development case showed that community plays a key role in both the emergence of challenges and in the determination of their solutions. The implications of this study showed that activity theory was a useful tool for understanding contextual issues. Therefore, instructional designers first developed relevant tools and community-based solutions. This study attempts to use activity theory in a prescriptive way, though it is known as a descriptive theory. Finally, since virtual world projects have many aspects, the variety of challenges and practical solutions presented in this study will provide practitioners with suggestions on how to overcome problems in future.

  16. The Effects of Orchestration on Musicians' and Nonmusicians' Perception of Musical Tension

    Science.gov (United States)

    Silvey, Brian A.

    2011-01-01

    The purpose of this study was to examine the effects of orchestration on musicians' and nonmusicians' (N = 40) perception of musical tension. Participants were asked to register their perceptions of tension using the Continuous Response Digital Interface dial while listening to three orchestrations (full orchestra, brass quintet, and solo piano)…

  17. Engaging with Mathematics in the Kindergarten. Orchestrating a Fairy Tale through Questioning and Use of Tools

    Science.gov (United States)

    Carlsen, Martin

    2013-01-01

    The aim of this study is to analyse how a kindergarten teacher orchestrated a mathematical activity involving a fairy tale. Taking a sociocultural perspective on learning and development, naturally occurring talk-in-interaction has been analysed in order to scrutinise the subtleties of the orchestration. The fairy tale "Goldilocks and the…

  18. A Study of Master's Degrees in Orchestral Conducting in the United States

    Science.gov (United States)

    St. John, Brian Allen

    2010-01-01

    In order to learn to be an orchestra conductor in the United States of America, students often begins their formal education by seeking to earn a master's degree in orchestral conducting. This project compiled a listing of American universities which offer a master's degree in orchestral conducting and categorized the component parts of their…

  19. Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.

    Science.gov (United States)

    Bonnavion, Patricia; Mickelsen, Laura E; Fujita, Akie; de Lecea, Luis; Jackson, Alexander C

    2016-11-15

    The hypothalamus is among the most phylogenetically conserved regions in the vertebrate brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By integrating signals arising from both the brain and periphery, it governs a litany of behaviourally important functions essential for survival. In particular, the lateral hypothalamic area (LHA) is central to the orchestration of sleep-wake states, feeding, energy balance and motivated behaviour. Underlying these diverse functions is a heterogeneous assembly of cell populations typically defined by neurochemical markers, such as the well-described neuropeptides hypocretin/orexin and melanin-concentrating hormone. However, anatomical and functional evidence suggests a rich diversity of other cell populations with complex neurochemical profiles that include neuropeptides, receptors and components of fast neurotransmission. Collectively, the LHA acts as a hub for the integration of diverse central and peripheral signals and, through complex local and long-range output circuits, coordinates adaptive behavioural responses to the environment. Despite tremendous progress in our understanding of the LHA, defining the identity of functionally discrete LHA cell types, and their roles in driving complex behaviour, remain significant challenges in the field. In this review, we discuss advances in our understanding of the neurochemical and cellular heterogeneity of LHA neurons and the recent application of powerful new techniques, such as opto- and chemogenetics, in defining the role of LHA circuits in feeding, reward, arousal and stress. From pioneering work to recent developments, we review how the interrogation of LHA cells and circuits is contributing to a mechanistic understanding of how the LHA coordinates complex behaviour.

  20. PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation.

    Science.gov (United States)

    O'Donnell, Amanda; Yang, Shen-Hsi; Sharrocks, Andrew D

    2013-12-01

    Transcriptional activation is accompanied by multiple molecular events that remodel the local chromatin environment in promoter regions. These molecular events are often orchestrated in response to the activation of signalling pathways, as exemplified by the response of immediate early genes such as FOS to ERK MAP kinase signalling. Here, we demonstrate that inducible NFI recruitment permits PARP1 binding to the FOS promoter by a mutually reinforcing loop. PARP1 and its poly(ADP-ribosyl)ation activity are required for maintaining FOS activation kinetics. We also show that the histone variant H2A.Z associates with the FOS promoter and acts in a transcription-suppressive manner. However, in response to ERK pathway signalling, H2A.Z is replaced by H2A; PARP1 activity is required to promote this exchange. Thus, our work has revealed an additional facet of PARP1 function in promoting dynamic remodelling of promoter-associated nucleosomes to allow transcriptional activation in response to cellular signalling.

  1. Controllable circuit

    DEFF Research Database (Denmark)

    2010-01-01

    A switch-mode power circuit comprises a controllable element and a control unit. The controllable element is configured to control a current in response to a control signal supplied to the controllable element. The control unit is connected to the controllable element and provides the control...

  2. The Live Access Server Scientific Product Generation Through Workflow Orchestration

    Science.gov (United States)

    Hankin, S.; Calahan, J.; Li, J.; Manke, A.; O'Brien, K.; Schweitzer, R.

    2006-12-01

    The Live Access Server (LAS) is a well-established Web-application for display and analysis of geo-science data sets. The software, which can be downloaded and installed by anyone, gives data providers an easy way to establish services for their on-line data holdings, so their users can make plots; create and download data sub-sets; compare (difference) fields; and perform simple analyses. Now at version 7.0, LAS has been in operation since 1994. The current "Armstrong" release of LAS V7 consists of three components in a tiered architecture: user interface, workflow orchestration and Web Services. The LAS user interface (UI) communicates with the LAS Product Server via an XML protocol embedded in an HTTP "get" URL. Libraries (APIs) have been developed in Java, JavaScript and perl that can readily generate this URL. As a result of this flexibility it is common to find LAS user interfaces of radically different character, tailored to the nature of specific datasets or the mindset of specific users. When a request is received by the LAS Product Server (LPS -- the workflow orchestration component), business logic converts this request into a series of Web Service requests invoked via SOAP. These "back- end" Web services perform data access and generate products (visualizations, data subsets, analyses, etc.). LPS then packages these outputs into final products (typically HTML pages) via Jakarta Velocity templates for delivery to the end user. "Fine grained" data access is performed by back-end services that may utilize JDBC for data base access; the OPeNDAP "DAPPER" protocol; or (in principle) the OGC WFS protocol. Back-end visualization services are commonly legacy science applications wrapped in Java or Python (or perl) classes and deployed as Web Services accessible via SOAP. Ferret is the default visualization application used by LAS, though other applications such as Matlab, CDAT, and GrADS can also be used. Other back-end services may include generation of Google

  3. Perception of orchestral musicians about work environment and conditions

    Directory of Open Access Journals (Sweden)

    Clarissa Stefani Teixeira

    2014-04-01

    Full Text Available The objective of this study was to investigate the perception of 11 orchestral string (viola and violin musicians of both genders with respect to their work environment and conditions. We applied a questionnaire with demographic information and the scale Profile of Work Environment and Working Conditions by Nahas et al. (2009, which analyzes the following components: physical environment, social environment, development and professional achievement, salary and benefits, and social relevance. The social environment component presented the highest score - 8.00 (1.50 points, followed by professional achievement - 7.11 (1.96 points, and physical environment - 6.89 (0.93 points. The salary and benefits provided by the orchestra presented the lowest score - 6.78 (1.56 points. In general, the musicians showed positive perceptions of the components related to work environment and working conditions. However, remuneration and social relevance are work bases that could contribute to improve the working conditions of these professionals.

  4. Automation Hooks Architecture Trade Study for Flexible Test Orchestration

    Science.gov (United States)

    Lansdowne, Chatwin A.; Maclean, John R.; Graffagnino, Frank J.; McCartney, Patrick A.

    2010-01-01

    We describe the conclusions of a technology and communities survey supported by concurrent and follow-on proof-of-concept prototyping to evaluate feasibility of defining a durable, versatile, reliable, visible software interface to support strategic modularization of test software development. The objective is that test sets and support software with diverse origins, ages, and abilities can be reliably integrated into test configurations that assemble and tear down and reassemble with scalable complexity in order to conduct both parametric tests and monitored trial runs. The resulting approach is based on integration of three recognized technologies that are currently gaining acceptance within the test industry and when combined provide a simple, open and scalable test orchestration architecture that addresses the objectives of the Automation Hooks task. The technologies are automated discovery using multicast DNS Zero Configuration Networking (zeroconf), commanding and data retrieval using resource-oriented Restful Web Services, and XML data transfer formats based on Automatic Test Markup Language (ATML). This open-source standards-based approach provides direct integration with existing commercial off-the-shelf (COTS) analysis software tools.

  5. Dynamin2 organizes lamellipodial actin networks to orchestrate lamellar actomyosin.

    Directory of Open Access Journals (Sweden)

    Manisha Menon

    Full Text Available Actin networks in migrating cells exist as several interdependent structures: sheet-like networks of branched actin filaments in lamellipodia; arrays of bundled actin filaments co-assembled with myosin II in lamellae; and actin filaments that engage focal adhesions. How these dynamic networks are integrated and coordinated to maintain a coherent actin cytoskeleton in migrating cells is not known. We show that the large GTPase dynamin2 is enriched in the distal lamellipod where it regulates lamellipodial actin networks as they form and flow in U2-OS cells. Within lamellipodia, dynamin2 regulated the spatiotemporal distributions of α-actinin and cortactin, two actin-binding proteins that specify actin network architecture. Dynamin2's action on lamellipodial F-actin influenced the formation and retrograde flow of lamellar actomyosin via direct and indirect interactions with actin filaments and a finely tuned GTP hydrolysis activity. Expression in dynamin2-depleted cells of a mutant dynamin2 protein that restores endocytic activity, but not activities that remodel actin filaments, demonstrated that actin filament remodeling by dynamin2 did not depend of its functions in endocytosis. Thus, dynamin2 acts within lamellipodia to organize actin filaments and regulate assembly and flow of lamellar actomyosin. We hypothesize that through its actions on lamellipodial F-actin, dynamin2 generates F-actin structures that give rise to lamellar actomyosin and for efficient coupling of F-actin at focal adhesions. In this way, dynamin2 orchestrates the global actin cytoskeleton.

  6. Cellular automata

    CERN Document Server

    Codd, E F

    1968-01-01

    Cellular Automata presents the fundamental principles of homogeneous cellular systems. This book discusses the possibility of biochemical computers with self-reproducing capability.Organized into eight chapters, this book begins with an overview of some theorems dealing with conditions under which universal computation and construction can be exhibited in cellular spaces. This text then presents a design for a machine embedded in a cellular space or a machine that can compute all computable functions and construct a replica of itself in any accessible and sufficiently large region of t

  7. Phospholipase D signaling : Orchestration by PIP2 and small GTPases

    NARCIS (Netherlands)

    Weernink, Paschal A. Oude; de Jesus, Maider Lopez; Schmidt, Martina

    2007-01-01

    Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival

  8. Affective Circuits

    DEFF Research Database (Denmark)

    to the intersecting streams of goods, people, ideas, and money as they circulate between African migrants and their kin who remain back home. They also show the complex ways that emotions become entangled in these exchanges. Examining how these circuits operate in domains of social life ranging from child fosterage......Moving between Africa and Europe, the book explores the many ways migrants sustain and rework family ties and intimate relationships at home and abroad. It demonstrates how their quotidian efforts—on such a mass scale—contribute to a broader process of social regeneration. The contributors point...

  9. Collective of mechatronics circuit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-02-15

    This book is composed of three parts, which deals with mechatronics system about sensor, circuit and motor. The contents of the first part are photo sensor of collector for output, locating detection circuit with photo interrupts, photo sensor circuit with CdS cell and lamp, interface circuit with logic and LED and temperature sensor circuit. The second part deals with oscillation circuit with crystal, C-R oscillation circuit, F-V converter, timer circuit, stability power circuit, DC amp and DC-DC converter. The last part is comprised of bridge server circuit, deformation bridge server, controlling circuit of DC motor, controlling circuit with IC for PLL and driver circuit of stepping motor and driver circuit of Brushless.

  10. miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.

    Science.gov (United States)

    Alvarez-Saavedra, Matías; Antoun, Ghadi; Yanagiya, Akiko; Oliva-Hernandez, Reynaldo; Cornejo-Palma, Daniel; Perez-Iratxeta, Carolina; Sonenberg, Nahum; Cheng, Hai-Ying M

    2011-02-15

    Mammalian circadian rhythms are synchronized to the external time by daily resetting of the suprachiasmatic nucleus (SCN) in response to light. As the master circadian pacemaker, the SCN coordinates the timing of diverse cellular oscillators in multiple tissues. Aberrant regulation of clock timing is linked to numerous human conditions, including cancer, cardiovascular disease, obesity, various neurological disorders and the hereditary disorder familial advanced sleep phase syndrome. Additionally, mechanisms that underlie clock resetting factor into the sleep and physiological disturbances experienced by night-shift workers and travelers with jet lag. The Ca(2+)/cAMP response element-binding protein-regulated microRNA, miR-132, is induced by light within the SCN and attenuates its capacity to reset, or entrain, the clock. However, the specific targets that are regulated by miR-132 and underlie its effects on clock entrainment remained elusive until now. Here, we show that genes involved in chromatin remodeling (Mecp2, Ep300, Jarid1a) and translational control (Btg2, Paip2a) are direct targets of miR-132 in the mouse SCN. Coordinated regulation of these targets underlies miR-132-dependent modulation of Period gene expression and clock entrainment: the mPer1 and mPer2 promoters are bound to and transcriptionally activated by MeCP2, whereas PAIP2A and BTG2 suppress the translation of the PERIOD proteins by enhancing mRNA decay. We propose that miR-132 is selectively enriched for chromatin- and translation-associated target genes and is an orchestrator of chromatin remodeling and protein translation within the SCN clock, thereby fine-tuning clock entrainment. These findings will further our understanding of mechanisms governing clock entrainment and its involvement in human diseases.

  11. Programming a Pavlovian-like conditioning circuit in Escherichia coli

    Science.gov (United States)

    Zhang, Haoqian; Lin, Min; Shi, Handuo; Ji, Weiyue; Huang, Longwen; Zhang, Xiaomeng; Shen, Shan; Gao, Rencheng; Wu, Shuke; Tian, Chengzhe; Yang, Zhenglin; Zhang, Guosheng; He, Siheng; Wang, Hao; Saw, Tiffany; Chen, Yiwei; Ouyang, Qi

    2014-01-01

    Synthetic genetic circuits are programmed in living cells to perform predetermined cellular functions. However, designing higher-order genetic circuits for sophisticated cellular activities remains a substantial challenge. Here we program a genetic circuit that executes Pavlovian-like conditioning, an archetypical sequential-logic function, in Escherichia coli. The circuit design is first specified by the subfunctions that are necessary for the single simultaneous conditioning, and is further genetically implemented using four function modules. During this process, quantitative analysis is applied to the optimization of the modules and fine-tuning of the interconnections. Analogous to classical Pavlovian conditioning, the resultant circuit enables the cells to respond to a certain stimulus only after a conditioning process. We show that, although the conditioning is digital in single cells, a dynamically progressive conditioning process emerges at the population level. This circuit, together with its rational design strategy, is a key step towards the implementation of more sophisticated cellular computing.

  12. Commutation circuit for an HVDC circuit breaker

    Science.gov (United States)

    Premerlani, William J.

    1981-01-01

    A commutation circuit for a high voltage DC circuit breaker incorporates a resistor capacitor combination and a charging circuit connected to the main breaker, such that a commutating capacitor is discharged in opposition to the load current to force the current in an arc after breaker opening to zero to facilitate arc interruption. In a particular embodiment, a normally open commutating circuit is connected across the contacts of a main DC circuit breaker to absorb the inductive system energy trapped by breaker opening and to limit recovery voltages to a level tolerable by the commutating circuit components.

  13. Injury and the orchestral environment: part II. Organisational culture, behavioural norms, and attitudes to injury.

    Science.gov (United States)

    Rickert, Dale Ll; Barrett, Margaret S; Ackermann, Bronwen J

    2014-06-01

    The organisational culture, behavioural norms, and attitudes of a workplace have a profound influence on levels of injury and illness amongst its workers. While this is well established in Work Health and Safety literature, very little research has attempted to understand the influence of organisational culture on injury risk in the orchestral profession. To address this, the current study aimed to investigate the influence of organisational culture on injury outcomes for orchestral musicians. Using a qualitative case study methodology, in-depth semi-structured interviews were undertaken with 10 professional orchestral cellists (2 freelance and 8 fulltime members) from a single Australian orchestra. After initial data analysis, further interviews were undertaken with a set of 5 orchestral management staff as a means of data triangulation. All data were analysed using a themes-based "analysis of narrative" approach. The findings indicate that an orchestral culture exists in which musicians see injury as a sign of weakness, failure, and poor musicianship. Such negative perceptions of injury influence musicians to play through considerable levels of pain and continue performing with injuries. Because of perceived judgment from the orchestral group, musicians were found to conceal injuries from colleagues and management staff. Freelance musicians felt that disclosing injuries may lead to decreased work opportunities, and both full-time and casual musicians felt that "opening up" about injury may subject them to group judgment about their technique or musicianship. The study suggests education measures which may be effective at influencing individual behaviours and attitudes as well as cultural change initiatives which could lead to long-term positive health outcomes in the orchestral workplace.

  14. Analog circuit design designing dynamic circuit response

    CERN Document Server

    Feucht, Dennis

    2010-01-01

    This second volume, Designing Dynamic Circuit Response builds upon the first volume Designing Amplifier Circuits by extending coverage to include reactances and their time- and frequency-related behavioral consequences.

  15. Analog circuit design designing waveform processing circuits

    CERN Document Server

    Feucht, Dennis

    2010-01-01

    The fourth volume in the set Designing Waveform-Processing Circuits builds on the previous 3 volumes and presents a variety of analog non-amplifier circuits, including voltage references, current sources, filters, hysteresis switches and oscilloscope trigger and sweep circuitry, function generation, absolute-value circuits, and peak detectors.

  16. Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states

    Directory of Open Access Journals (Sweden)

    Allison eGraebner

    2015-08-01

    Full Text Available A major question in systems neuroscience is how a single population of neurons can interact with the rest of the brain to orchestrate complex behavioral states. The hypothalamus contains many such discrete neuronal populations that individually regulate arousal, feeding, and drinking. For example, hypothalamic neurons that express hypocretin (Hcrt neuropeptides can sense homeostatic and metabolic factors affecting wakefulness and orchestrate organismal arousal. Neurons that express agouti-related protein (AgRP can sense the metabolic needs of the body and orchestrate a state of hunger. The organum vasculosum of the lamina terminalis (OVLT can detect the hypertonicity of blood and orchestrate a state of thirst. Each hypothalamic population is sufficient to generate complicated behavioral states through the combined efforts of distinct efferent projections. The principal challenge to understanding these brain systems is therefore to determine the individual roles of each downstream projection for each behavioral state. In recent years, the development and application of temporally precise, genetically encoded tools have greatly improved our understanding of the structure and function of these neural systems. This review will survey recent advances in our understanding of how these individual hypothalamic populations can orchestrate complicated behavioral states due to the combined efforts of individual downstream projections.

  17. Cellular Telephone

    Institute of Scientific and Technical Information of China (English)

    杨周

    1996-01-01

    Cellular phones, used in automobiles, airliners, and passenger trains, are basically low-power radiotelephones. Calls go through radio transmitters that are located within small geographical units called cells. Because each cell’s signals are too weak to interfere with those of other cells operating on the same fre-

  18. Cellular and Molecular Basis of Cerebellar Development

    Directory of Open Access Journals (Sweden)

    Salvador eMartinez

    2013-06-01

    Full Text Available Historically, the molecular and cellular mechanisms of cerebellar development were investigated through structural descriptions and studying spontaneous mutations in animal models and humans. Advances in experimental embryology, genetic engineering and neuroimaging techniques render today the possibility to approach the analysis of molecular mechanisms underlying histogenesis and morphogenesis of the cerebellum by experimental designs. Several genes and molecules were identified to be involved in the cerebellar plate regionalization, specification and differentiation of cerebellar neurons, as well as the establishment of cellular migratory routes and the subsequent neuronal connectivity. Indeed, pattern formation of the cerebellum requires the adequate orchestration of both key morphogenetic signals, arising from distinct brain regions, and local expression of specific transcription factors. Thus, the present review wants to revisit and discuss these morphogenetic and molecular mechanisms taking place during cerebellar development in order to understand causal processes regulating cerebellar cytoarchitecture, its highly topographically ordered circuitry and its role in brain function.

  19. 基于注解的服务编排%Annotation-Based Service Orchestration

    Institute of Scientific and Technical Information of China (English)

    王斌; 黄鹤远; 徐景民; 朱俊

    2009-01-01

    Service orchestration plays a vital role in assembling services into business processes in a Service Oriented Arcmtecture.In current practices,the orchestrating logic is usually described by a process language,which is theretore separated from the services in the system implemented by certain programming language.It introduces two issues:1)It cost additional efforts for developers to be proficient with a new process language/script,and its running environment.2)It causes development performance degradation due to transtormation efforts for process language and programming language,such as transforms Java services into web services.To overcome these issues,this paper proposes a novel alternative system which takes advantage of the annotation construct of Java programming language to represent business processes.Through the expenments,we found that developers can efficiently develop business processes based on their current proficient programming language skill using the proposed system to achieve the service orchestration.

  20. The nervous system orchestrates and integrates craniofacial development: a review

    Directory of Open Access Journals (Sweden)

    Kaj eFried

    2016-02-01

    Full Text Available Development of a head is a dazzlingly complex process: a number of distinct cellular sources including cranial ecto- and endoderm, mesoderm and neural crest contribute to facial and other structures. In the head, an extremely fine-tuned developmental coordination of CNS, peripheral neural components, sensory organs and a musculo-skeletal apparatus occurs, which provides protection and functional integration. The face can to a large extent be considered as an assembly of sensory systems encased and functionally fused with appendages represented by jaws. Here we review how the developing brain, neurogenic placodes and peripheral nerves influence the morphogenesis of surrounding tissues as a part of various general integrative processes in the head. The mechanisms of this impact, as we understand it now, span from the targeted release of the morphogens necessary for shaping to providing a niche for cellular sources required in later development. In this review we also discuss the most recent findings and ideas related to how peripheral nerves and nerve-associated cells contribute to craniofacial development, including teeth, during the post- neural crest period and potentially in regeneration.

  1. RB, the conductor that orchestrates life, death and differentiation.

    Science.gov (United States)

    Khidr, L; Chen, P-L

    2006-08-28

    The retinoblastoma susceptibility gene was the first tumor suppressor gene identified in humans and the first tumor suppressor gene knocked out by targeted deletion in mice. RB serves as a transducer between the cell cycle machinery and promoter-specific transcription factors, its most documented activity being the repression of the E2F family of transcription factors, which regulate the expression of genes involved in cell proliferation and survival. Recent investigations of RB function suggest that it works as a fundamental regulator to coordinate pathways of cellular growth and differentiation. In this review, we unravel the novel role of an equally important aspect of RB in downregulating the differentiation inhibitor EID-1 during cellular differentiation by teasing apart the signal, which elicit differentiation and limit cell cycle progression, since the molecular mechanisms relating to RB activation of differentiation is much less understood. We review the various roles for RB in differentiation of neurons, muscle, adipose tissue, and the retina. In addition, we provide an update for the current models of the role of RB in cell cycle to entry and exit, extending the view toward chromatin remodeling and expose the dichotomies in the regulation of RB family members. We conclude with a discussion of a novel RB regulatory network, incorporating the dynamic contribution of EID family proteins.

  2. Solid-state circuits

    CERN Document Server

    Pridham, G J

    2013-01-01

    Solid-State Circuits provides an introduction to the theory and practice underlying solid-state circuits, laying particular emphasis on field effect transistors and integrated circuits. Topics range from construction and characteristics of semiconductor devices to rectification and power supplies, low-frequency amplifiers, sine- and square-wave oscillators, and high-frequency effects and circuits. Black-box equivalent circuits of bipolar transistors, physical equivalent circuits of bipolar transistors, and equivalent circuits of field effect transistors are also covered. This volume is divided

  3. Simple Autonomous Chaotic Circuits

    Science.gov (United States)

    Piper, Jessica; Sprott, J.

    2010-03-01

    Over the last several decades, numerous electronic circuits exhibiting chaos have been proposed. Non-autonomous circuits with as few as two components have been developed. However, the operation of such circuits relies on the non-ideal behavior of the devices used, and therefore the circuit equations can be quite complex. In this paper, we present two simple autonomous chaotic circuits using only opamps and linear passive components. The circuits each use one opamp as a comparator, to provide a signum nonlinearity. The chaotic behavior is robust, and independent of nonlinearities in the passive components. Moreover, the circuit equations are among the algebraically simplest chaotic systems yet constructed.

  4. Circuit analysis for dummies

    CERN Document Server

    Santiago, John

    2013-01-01

    Circuits overloaded from electric circuit analysis? Many universities require that students pursuing a degree in electrical or computer engineering take an Electric Circuit Analysis course to determine who will ""make the cut"" and continue in the degree program. Circuit Analysis For Dummies will help these students to better understand electric circuit analysis by presenting the information in an effective and straightforward manner. Circuit Analysis For Dummies gives you clear-cut information about the topics covered in an electric circuit analysis courses to help

  5. Solenoid-Simulation Circuit

    Science.gov (United States)

    Simon, R. A.

    1986-01-01

    Electrical properties of solenoids imitated for tests of control circuits. Simulation circuit imitates voltage and current responses of two engine-controlling solenoids. Used in tests of programs of digital engine-control circuits, also provides electronic interface with circuits imitating electrical properties of pressure sensors and linear variable-differential transformers. Produces voltages, currents, delays, and discrete turnon and turnoff signals representing operation of solenoid in engine-control relay. Many such circuits used simulating overall engine circuitry.

  6. Spindle Activity Orchestrates Plasticity during Development and Sleep

    Directory of Open Access Journals (Sweden)

    Christoph Lindemann

    2016-01-01

    Full Text Available Spindle oscillations have been described during early brain development and in the adult brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle bursts (NSBs and adult sleep spindles (ASSs show differences in their occurrence, spatial distribution, and underlying mechanisms. While NSBs have been proposed to coordinate the refinement of the maturating neuronal network, ASSs are associated with the implementation of acquired information within existing networks. Along with these functional differences, separate synaptic plasticity mechanisms seem to be recruited. Here, we review the generation of spindle oscillations in the developing and adult brain and discuss possible implications of their differences for synaptic plasticity. The first part of the review is dedicated to the generation and function of ASSs with a particular focus on their role in healthy and impaired neuronal networks. The second part overviews the present knowledge of spindle activity during development and the ability of NSBs to organize immature circuits. Studies linking abnormal maturation of brain wiring with neurological and neuropsychiatric disorders highlight the importance to better elucidate neonatal plasticity rules in future research.

  7. A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae

    DEFF Research Database (Denmark)

    Val, Marie-Eve; Marbouty, Martial; Martins, Francisco de Lemos

    2016-01-01

    of the important differences between plasmids and chromosomes is that the latter replicate during a defined period of the cell cycle, ensuring a single round of replication per cell. Vibrio cholerae carries two circular chromosomes, Chr1 and Chr2, which are replicated in a well-orchestrated manner with the cell...

  8. Kindergarten Teachers' Orchestration of Mathematical Activities Afforded by Technology: Agency and Mediation

    Science.gov (United States)

    Carlsen, Martin; Erfjord, Ingvald; Hundeland, Per Sigurd; Monaghan, John

    2016-01-01

    This paper focuses on kindergarten teachers' interactions with young children during mathematical learning activities involving the use of digital tools. We aim to characterise the teachers' roles and actions in these activities and extend considerations of teachers' orchestrations current in the research literature with regard to agency and…

  9. Webbing and Orchestration. Two Interrelated Views on Digital Tools in Mathematics Education

    Science.gov (United States)

    Trouche, Luc; Drijvers, Paul

    2014-01-01

    The integration of digital tools in mathematics education is considered both promising and problematic. To deal with this issue, notions of "webbing" and "instrumental orchestration" are developed. However, the two seemed to be disconnected, and having different cultural and theoretical roots. In this article, we investigate…

  10. Webbing and orchestration : Two interrelated views on digital tools in mathematics education

    NARCIS (Netherlands)

    Trouche, L.; Drijvers, Paul

    2014-01-01

    The integration of digital tools in mathematics education is considered both promising and problematic. To deal with this issue, notions of webbing and instrumental orchestration are developed. However, the two seemed to be disconnected, and having different cultural and theoretical roots. In this a

  11. WPS orchestration using the Taverna workbench: The eScience approach

    Science.gov (United States)

    de Jesus, J.; Walker, P.; Grant, M.; Groom, S.

    2012-10-01

    eScience is an umbrella concept which covers internet technologies, such as web service orchestration that involves manipulation and processing of high volumes of data, using simple and efficient methodologies. This concept is normally associated with bioinformatics, but nothing prevents the use of an identical approach for geoinfomatics and OGC (Open Geospatial Consortium) web services like WPS (Web Processing Service). In this paper we present an extended WPS implementation based on the PyWPS framework using an automatically generated WSDL (Web Service Description Language) XML document that replicates the WPS input/output document structure used during an Execute request to a server. Services are accessed using a modified SOAP (Simple Object Access Protocol) interface provided by PyWPS, that uses service and input/outputs identifiers as element names. The WSDL XML document is dynamically generated by applying XSLT (Extensible Stylesheet Language Transformation) to the getCapabilities XML document that is generated by PyWPS. The availability of the SOAP interface and WSDL description allows WPS instances to be accessible to workflow development software like Taverna, enabling users to build complex workflows using web services represented by interconnecting graphics. Taverna will transform the visual representation of the workflow into a SCUFL (Simple Conceptual Unified Flow Language) based XML document that can be run internally or sent to a Taverna orchestration server. SCUFL uses a dataflow-centric orchestration model as opposed to the more commonly used orchestration language BPEL (Business Process Execution Language) which is process-centric.

  12. Orchestrating innovation networks: The case of innovation brokers in the agri-food sector

    NARCIS (Netherlands)

    Batterink, M.H.; Wubben, E.F.M.; Klerkx, L.W.A.; Omta, S.W.F.

    2010-01-01

    This explorative study of network orchestration processes conducted by innovation brokers addresses new issues in bridging small and medium-sized enterprises (SMEs) and research institutes in innovation networks. The study includes four in-depth case studies in the agri-food sector from different co

  13. Hidden circuits and argumentation

    Science.gov (United States)

    Leinonen, Risto; Kesonen, Mikko H. P.; Hirvonen, Pekka E.

    2016-11-01

    Despite the relevance of DC circuits in everyday life and schools, they have been shown to cause numerous learning difficulties at various school levels. In the course of this article, we present a flexible method for teaching DC circuits at lower secondary level. The method is labelled as hidden circuits, and the essential idea underlying hidden circuits is in hiding the actual wiring of DC circuits, but to make their behaviour evident for pupils. Pupils are expected to find out the wiring of the circuit which should enhance their learning of DC circuits. We present two possible ways to utilise hidden circuits in a classroom. First, they can be used to test and enhance pupils’ conceptual understanding when pupils are expected to find out which one of the offered circuit diagram options corresponds to the actual circuit shown. This method aims to get pupils to evaluate the circuits holistically rather than locally, and as a part of that aim this method highlights any learning difficulties of pupils. Second, hidden circuits can be used to enhance pupils’ argumentation skills with the aid of argumentation sheet that illustrates the main elements of an argument. Based on the findings from our co-operating teachers and our own experiences, hidden circuits offer a flexible and motivating way to supplement teaching of DC circuits.

  14. Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin

    Directory of Open Access Journals (Sweden)

    Daniel Wehner

    2014-02-01

    Full Text Available Zebrafish regenerate their fins via the formation of a population of progenitor cells, the blastema. Wnt/β-catenin signaling is essential for blastemal cell proliferation and patterning of the overlying epidermis. Yet, we find that β-catenin signaling is neither active in the epidermis nor the majority of the proliferative blastemal cells. Rather, tissue-specific pathway interference indicates that Wnt signaling in the nonproliferative distal blastema is required for cell proliferation in the proximal blastema, and signaling in cells lining the osteoblasts directs osteoblast differentiation. Thus, Wnt signaling regulates epidermal patterning, blastemal cell proliferation, and osteoblast maturation indirectly via secondary signals. Gene expression profiling, chromatin immunoprecipitation, and functional rescue experiments suggest that Wnt/β-catenin signaling acts through Fgf and Bmp signaling to control epidermal patterning, whereas retinoic acid and Hedgehog signals mediate its effects on blastemal cell proliferation. We propose that Wnt signaling orchestrates fin regeneration by defining organizing centers that instruct cellular behaviors of adjacent tissues.

  15. Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms.

    LENUS (Irish Health Repository)

    Corvin, Aiden P

    2012-06-27

    Insulin-like growth factor-1 (IGF1) and its active peptide (1-3)IGF1 modulate brain growth and plasticity and are candidate molecules for treatment of brain disorders. IGF1 N-terminal portion is naturally cleaved to generate the tri-peptide (1-3)IGF1 (glycine-praline-glutamate). IGF1 and (1-3)IGF have been proposed as treatment for neuropathologies, yet their effect on nerve cells has not been directly compared. In this study we examine the effects of IGF1 and (1-3)IGF1 in primary cortical cultures and measure the expression levels of markers for intracellular pathways and synaptic function. We find that both treatments activate the IGF1 receptor and enhance the expression of synaptic markers, however, they activate different intracellular pathways. Furthermore, (1-3)IGF1 administration increases the expression of endogenous IGF1, suggesting a direct interaction between the two molecules. The results show that the two molecules increase the expression of synaptic proteins through activating different cellular mechanisms.

  16. The circuit designer's companion

    CERN Document Server

    Williams, Tim

    2013-01-01

    The Circuit Designer's Companion covers the theoretical aspects and practices in analogue and digital circuit design. Electronic circuit design involves designing a circuit that will fulfill its specified function and designing the same circuit so that every production model of it will fulfill its specified function, and no other undesired and unspecified function.This book is composed of nine chapters and starts with a review of the concept of grounding, wiring, and printed circuits. The subsequent chapters deal with the passive and active components of circuitry design. These topics are foll

  17. Intuitive analog circuit design

    CERN Document Server

    Thompson, Marc

    2013-01-01

    Intuitive Analog Circuit Design outlines ways of thinking about analog circuits and systems that let you develop a feel for what a good, working analog circuit design should be. This book reflects author Marc Thompson's 30 years of experience designing analog and power electronics circuits and teaching graduate-level analog circuit design, and is the ideal reference for anyone who needs a straightforward introduction to the subject. In this book, Dr. Thompson describes intuitive and ""back-of-the-envelope"" techniques for designing and analyzing analog circuits, including transistor amplifi

  18. Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits.

    Science.gov (United States)

    Hoshina, Naosuke; Tanimura, Asami; Yamasaki, Miwako; Inoue, Takeshi; Fukabori, Ryoji; Kuroda, Teiko; Yokoyama, Kazumasa; Tezuka, Tohru; Sagara, Hiroshi; Hirano, Shinji; Kiyonari, Hiroshi; Takada, Masahiko; Kobayashi, Kazuto; Watanabe, Masahiko; Kano, Masanobu; Nakazawa, Takanobu; Yamamoto, Tadashi

    2013-06-05

    Highly topographic organization of neural circuits exists for the regulation of various brain functions in corticobasal ganglia circuits. Although neural circuit-specific refinement during synapse development is essential for the execution of particular neural functions, the molecular and cellular mechanisms for synapse refinement are largely unknown. Here, we show that protocadherin 17 (PCDH17), one of the nonclustered δ2-protocadherin family members, is enriched along corticobasal ganglia synapses in a zone-specific manner during synaptogenesis and regulates presynaptic assembly in these synapses. PCDH17 deficiency in mice causes facilitated presynaptic vesicle accumulation and enhanced synaptic transmission efficacy in corticobasal ganglia circuits. Furthermore, PCDH17(-/-) mice exhibit antidepressant-like phenotypes that are known to be regulated by corticobasal ganglia circuits. Our findings demonstrate a critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors.

  19. Calcium signaling orchestrates glioblastoma development: Facts and conjunctures.

    Science.gov (United States)

    Leclerc, Catherine; Haeich, Jacques; Aulestia, Francisco J; Kilhoffer, Marie-Claude; Miller, Andrew L; Néant, Isabelle; Webb, Sarah E; Schaeffer, Etienne; Junier, Marie-Pierre; Chneiweiss, Hervé; Moreau, Marc

    2016-06-01

    While it is a relatively rare disease, glioblastoma multiform (GBM) is one of the more deadly adult cancers. Following current interventions, the tumor is never eliminated whatever the treatment performed; whether it is radiotherapy, chemotherapy, or surgery. One hypothesis to explain this poor outcome is the "cancer stem cell" hypothesis. This concept proposes that a minority of cells within the tumor mass share many of the properties of adult neural stem cells and it is these that are responsible for the growth of the tumor and its resistance to existing therapies. Accumulating evidence suggests that Ca(2+) might also be an important positive regulator of tumorigenesis in GBM, in processes involving quiescence, maintenance, proliferation, or migration. Glioblastoma tumors are generally thought to develop by co-opting pathways that are involved in the formation of an organ. We propose that the cells initiating the tumor, and subsequently the cells of the tumor mass, must hijack the different checkpoints that evolution has selected in order to prevent the pathological development of an organ. In this article, two main points are discussed. (i) The first is the establishment of a so-called "cellular society," which is required to create a favorable microenvironment. (ii) The second is that GBM can be considered to be an organism, which fights to survive and develop. Since GBM evolves in a limited space, its only chance of development is to overcome the evolutionary checkpoints. For example, the deregulation of the normal Ca(2+) signaling elements contributes to the progression of the disease. Thus, by manipulating the Ca(2+) signaling, the GBM cells might not be killed, but might be reprogrammed toward a new fate that is either easy to cure or that has no aberrant functioning. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.

  20. Electrical Circuits and Water Analogies

    Science.gov (United States)

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  1. Circuits on Cylinders

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Arnsfelt; Miltersen, Peter Bro; Vinay, V

    2006-01-01

    We consider the computational power of constant width polynomial size cylindrical circuits and nondeterministic branching programs. We show that every function computed by a Pi2 o MOD o AC0 circuit can also be computed by a constant width polynomial size cylindrical nondeterministic branching...... program (or cylindrical circuit) and that every function computed by a constant width polynomial size cylindrical circuit belongs to ACC0....

  2. Electric circuits essentials

    CERN Document Server

    REA, Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Electric Circuits I includes units, notation, resistive circuits, experimental laws, transient circuits, network theorems, techniques of circuit analysis, sinusoidal analysis, polyph

  3. Load testing circuit

    DEFF Research Database (Denmark)

    2009-01-01

    A load testing circuit a circuit tests the load impedance of a load connected to an amplifier. The load impedance includes a first terminal and a second terminal, the load testing circuit comprising a signal generator providing a test signal of a defined bandwidth to the first terminal of the load...

  4. Short-circuit logic

    NARCIS (Netherlands)

    Bergstra, J.A.; Ponse, A.

    2010-01-01

    Short-circuit evaluation denotes the semantics of propositional connectives in which the second argument is only evaluated if the first argument does not suffice to determine the value of the expression. In programming, short-circuit evaluation is widely used. A short-circuit logic is a variant of p

  5. Piezoelectric drive circuit

    Science.gov (United States)

    Treu, Jr., Charles A.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes.

  6. Signal sampling circuit

    NARCIS (Netherlands)

    Louwsma, Simon Minze; Vertregt, Maarten

    2011-01-01

    A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital converte

  7. Signal sampling circuit

    NARCIS (Netherlands)

    Louwsma, Simon Minze; Vertregt, Maarten

    2010-01-01

    A sampling circuit for sampling a signal is disclosed. The sampling circuit comprises a plurality of sampling channels adapted to sample the signal in time-multiplexed fashion, each sampling channel comprising a respective track-and-hold circuit connected to a respective analogue to digital converte

  8. Reversible Logic Circuit Synthesis

    CERN Document Server

    Shende, V V; Markov, I L; Prasad, A K; Hayes, John P.; Markov, Igor L.; Prasad, Aditya K.; Shende, Vivek V.

    2002-01-01

    Reversible, or information-lossless, circuits have applications in digital signal processing, communication, computer graphics and cryptography. They are also a fundamental requirement for quantum computation. We investigate the synthesis of reversible circuits that employ a minimum number of gates and contain no redundant input-output line-pairs (temporary storage channels). We propose new constructions for reversible circuits composed of NOT, Controlled-NOT, and TOFFOLI gates (the CNT gate library) based on permutation theory. A new algorithm is given to synthesize optimal reversible circuits using an arbitrary gate library. We also describe much faster heuristic algorithms. We also pursue applications of the proposed techniques to the synthesis of quantum circuits.

  9. Feedback in analog circuits

    CERN Document Server

    Ochoa, Agustin

    2016-01-01

    This book describes a consistent and direct methodology to the analysis and design of analog circuits with particular application to circuits containing feedback. The analysis and design of circuits containing feedback is generally presented by either following a series of examples where each circuit is simplified through the use of insight or experience (someone else’s), or a complete nodal-matrix analysis generating lots of algebra. Neither of these approaches leads to gaining insight into the design process easily. The author develops a systematic approach to circuit analysis, the Driving Point Impedance and Signal Flow Graphs (DPI/SFG) method that does not require a-priori insight to the circuit being considered and results in factored analysis supporting the design function. This approach enables designers to account fully for loading and the bi-directional nature of elements both in the feedback path and in the amplifier itself, properties many times assumed negligible and ignored. Feedback circuits a...

  10. Exact Threshold Circuits

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Arnsfelt; Podolskii, Vladimir V.

    2010-01-01

    We initiate a systematic study of constant depth Boolean circuits built using exact threshold gates. We consider both unweighted and weighted exact threshold gates and introduce corresponding circuit classes. We next show that this gives a hierarchy of classes that seamlessly interleave with the ......We initiate a systematic study of constant depth Boolean circuits built using exact threshold gates. We consider both unweighted and weighted exact threshold gates and introduce corresponding circuit classes. We next show that this gives a hierarchy of classes that seamlessly interleave...... with the well-studied corresponding hierarchies defined using ordinary threshold gates. A major open problem in Boolean circuit complexity is to provide an explicit super-polynomial lower bound for depth two threshold circuits. We identify the class of depth two exact threshold circuits as a natural subclass...

  11. DECENTRALIZED ORCHESTRATION OF COMPOSITE OGC WEB PROCESSING SERVICES IN THE CLOUD

    Directory of Open Access Journals (Sweden)

    F. Xiao

    2016-09-01

    Full Text Available Current web-based GIS or RS applications generally rely on centralized structure, which has inherent drawbacks such as single points of failure, network congestion, and data inconsistency, etc. The inherent disadvantages of traditional GISs need to be solved for new applications on Internet or Web. Decentralized orchestration offers performance improvements in terms of increased throughput and scalability and lower response time. This paper investigates build time and runtime issues related to decentralized orchestration of composite geospatial processing services based on OGC WPS standard specification. A case study of dust storm detection was demonstrated to evaluate the proposed method and the experimental results indicate that the method proposed in this study is effective for its ability to produce the high quality solution at a low cost of communications for geospatial processing service composition problem.

  12. Context-Based Orchestration for Control of Resource-Efficient Manufacturing Processes

    Directory of Open Access Journals (Sweden)

    Michael Schwarz

    2012-08-01

    Full Text Available The increasing competition between manufacturers, the shortening of innovation cycles and the growing importance of resource-efficient manufacturing demand a higher versatility of factory automation. Service-oriented approaches depict a promising possibility to realize new control architectures by encapsulating the functionality of mechatronic devices into services. An efficient discovery, context-based selection and dynamic orchestration of these services are the key features for the creation of highly adaptable manufacturing processes. We describe a semantic service discovery and ad-hoc orchestration system, which is able to react to new process variants and changed contextual information (e.g., failure of field devices, requirements on the consumption of resources. Because a standardized vocabulary, especially for the description of mechatronic functionalities, is still missing in the manufacturing domain, the semantic description of services, processes and manufacturing plants as well as the semantic interpretation of contextual information play an important part.

  13. Decentralized Orchestration of Composite Ogc Web Processing Services in the Cloud

    Science.gov (United States)

    Xiao, F.; Shea, G. Y. K.; Cao, J.

    2016-09-01

    Current web-based GIS or RS applications generally rely on centralized structure, which has inherent drawbacks such as single points of failure, network congestion, and data inconsistency, etc. The inherent disadvantages of traditional GISs need to be solved for new applications on Internet or Web. Decentralized orchestration offers performance improvements in terms of increased throughput and scalability and lower response time. This paper investigates build time and runtime issues related to decentralized orchestration of composite geospatial processing services based on OGC WPS standard specification. A case study of dust storm detection was demonstrated to evaluate the proposed method and the experimental results indicate that the method proposed in this study is effective for its ability to produce the high quality solution at a low cost of communications for geospatial processing service composition problem.

  14. IP Models to Orchestrate Innovation Ecosystems: IMEC, A PUBLIC RESEARCH INSTITUTE IN NANO-ELECTRONICS

    OpenAIRE

    Leten, Bart; Vanhaverbeke, Wim; Roijakkers, Nadine; Clerix, André; Van Helleputte, Johan

    2013-01-01

    Companies increasingly organize innovation activities within innovation ecosystems. This study illustrates the central role of the IP-model that an orchestrator develops for the innovation ecosystem partners. The governance of IP is instrumental for the success of innovation ecosystems as it determines the value appropriation potential for the ecosystem partners and positively influences the success of innovation ecosystems. The insights are based on a case study of IMEC, a public research in...

  15. Webbing and orchestration. Two interrelated views on digital tools in mathematics education

    OpenAIRE

    Trouche, Luc; Drijvers, Paul

    2014-01-01

    International audience; The integration of digital tools in mathematics education is considered both promising and problematic. To deal with this issue, notions of webbing and instrumental orchestration are developed. However, the two seemed to be disconnected, and having different cultural and theoretical roots. In this article, we investigate the distinct and joint journeys of these two theoretical perspectives. Taking some key moments in recent history as points of de- parture, we conclude...

  16. Software Defined Resource Orchestration System for Multitask Application in Heterogeneous Mobile Cloud Computing

    Directory of Open Access Journals (Sweden)

    Qi Qi

    2016-01-01

    Full Text Available The mobile cloud computing (MCC that combines mobile computing and cloud concept takes wireless access network as the transmission medium and uses mobile devices as the client. When offloading the complicated multitask application to the MCC environment, each task executes individually in terms of its own computation, storage, and bandwidth requirement. Due to user’s mobility, the provided resources contain different performance metrics that may affect the destination choice. Nevertheless, these heterogeneous MCC resources lack integrated management and can hardly cooperate with each other. Thus, how to choose the appropriate offload destination and orchestrate the resources for multitask is a challenge problem. This paper realizes a programming resource provision for heterogeneous energy-constrained computing environments, where a software defined controller is responsible for resource orchestration, offload, and migration. The resource orchestration is formulated as multiobjective optimal problem that contains the metrics of energy consumption, cost, and availability. Finally, a particle swarm algorithm is used to obtain the approximate optimal solutions. Simulation results show that the solutions for all of our studied cases almost can hit Pareto optimum and surpass the comparative algorithm in approximation, coverage, and execution time.

  17. An Orchestrating Evaluation of Complex Educational Technologies: a Case Study of a CSCL System

    Directory of Open Access Journals (Sweden)

    Luis P. Prieto

    2014-06-01

    Full Text Available As digital technologies permeate every aspect of our lives, the complexity of the educational settings, and of the technological support we use within them, unceasingly rises. This increased complexity, along with the need for educational practitioners to apply such technologies within multi-constraint authentic settings, has given rise to the notion of technology-enhanced learning practice as “orchestration of learning”. However, at the same time, the complexity involved in evaluating the benefits of such educational technologies has also increased, prompting questions about the way evaluators can cope with the different places, technologies, informants and issues involved in their evaluation activity. By proposing the notion of “orchestrating evaluation”, this paper tries to reconcile the often disparate “front office accounts” of research publications and the “shop floor practice” of evaluation of educational technology, through the case study of evaluating a system to help teachers in coordinating computer-supported collaborative learning (CSCL scenarios. We reuse an internationally-evaluated conceptual framework of “orchestration aspects” (design, management, adaptation, pragmatism, etc. to structure the case‟s narrative, showing how the original evaluation questions and methods were modulated in the face of the multiple (authentic evaluation setting constraints.

  18. WWWinda Orchestrator: a mechanism for coordinating distributed flocks of Java Applets

    Science.gov (United States)

    Gutfreund, Yechezkal-Shimon; Nicol, John R.

    1997-01-01

    The WWWinda Orchestrator is a simple but powerful tool for coordinating distributed Java applets. Loosely derived from the Linda programming language developed by David Gelernter and Nicholas Carriero of Yale, WWWinda implements a distributed shared object space called TupleSpace where applets can post, read, or permanently store arbitrary Java objects. In this manner, applets can easily share information without being aware of the underlying communication mechanisms. WWWinda is a very useful for orchestrating flocks of distributed Java applets. Coordination event scan be posted to WWWinda TupleSpace and used to orchestrate the actions of remote applets. Applets can easily share information via the TupleSpace. The technology combines several functions in one simple metaphor: distributed web objects, remote messaging between applets, distributed synchronization mechanisms, object- oriented database, and a distributed event signaling mechanisms. WWWinda can be used a s platform for implementing shared VRML environments, shared groupware environments, controlling remote devices such as cameras, distributed Karaoke, distributed gaming, and shared audio and video experiences.

  19. Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

    Science.gov (United States)

    Rossiello, Francesca; Herbig, Utz; Longhese, Maria Pia; Fumagalli, Marzia; d'Adda di Fagagna, Fabrizio

    2014-06-01

    The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at telomeres. Since the vast majority of the cells in mammals are non-proliferating, how do they age? Are telomeres involved? Also oncogene activation causes cellular senescence due to altered DNA replication and DDR activation in particular at the telomeres. Is there a common mechanism shared among apparently distinct types of cellular senescence? And what is the role of telomeric DNA damage?

  20. Analog circuit design

    CERN Document Server

    Dobkin, Bob

    2012-01-01

    Analog circuit and system design today is more essential than ever before. With the growth of digital systems, wireless communications, complex industrial and automotive systems, designers are being challenged to develop sophisticated analog solutions. This comprehensive source book of circuit design solutions aids engineers with elegant and practical design techniques that focus on common analog challenges. The book's in-depth application examples provide insight into circuit design and application solutions that you can apply in today's demanding designs. <

  1. Parallelizing quantum circuit synthesis

    OpenAIRE

    Di Matteo, Olivia; Mosca, Michele

    2016-01-01

    Quantum circuit synthesis is the process in which an arbitrary unitary operation is decomposed into a sequence of gates from a universal set, typically one which a quantum computer can implement both efficiently and fault-tolerantly. As physical implementations of quantum computers improve, the need is growing for tools which can effectively synthesize components of the circuits and algorithms they will run. Existing algorithms for exact, multi-qubit circuit synthesis scale exponentially in t...

  2. Regenerative feedback resonant circuit

    Science.gov (United States)

    Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

    2014-09-02

    A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

  3. Analog circuits cookbook

    CERN Document Server

    Hickman, Ian

    2013-01-01

    Analog Circuits Cookbook presents articles about advanced circuit techniques, components and concepts, useful IC for analog signal processing in the audio range, direct digital synthesis, and ingenious video op-amp. The book also includes articles about amplitude measurements on RF signals, linear optical imager, power supplies and devices, and RF circuits and techniques. Professionals and students of electrical engineering will find the book informative and useful.

  4. Timergenerator circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Timer/Generator Circuits Manual is an 11-chapter text that deals mainly with waveform generator techniques and circuits. Each chapter starts with an explanation of the basic principles of its subject followed by a wide range of practical circuit designs. This work presents a total of over 300 practical circuits, diagrams, and tables.Chapter 1 outlines the basic principles and the different types of generator. Chapters 2 to 9 deal with a specific type of waveform generator, including sine, square, triangular, sawtooth, and special waveform generators pulse. These chapters also include pulse gen

  5. CMOS circuits manual

    CERN Document Server

    Marston, R M

    1995-01-01

    CMOS Circuits Manual is a user's guide for CMOS. The book emphasizes the practical aspects of CMOS and provides circuits, tables, and graphs to further relate the fundamentals with the applications. The text first discusses the basic principles and characteristics of the CMOS devices. The succeeding chapters detail the types of CMOS IC, including simple inverter, gate and logic ICs and circuits, and complex counters and decoders. The last chapter presents a miscellaneous collection of two dozen useful CMOS circuits. The book will be useful to researchers and professionals who employ CMOS circu

  6. Electronic devices and circuits

    CERN Document Server

    Pridham, Gordon John

    1968-01-01

    Electronic Devices and Circuits, Volume 1 deals with the design and applications of electronic devices and circuits such as passive components, diodes, triodes and transistors, rectification and power supplies, amplifying circuits, electronic instruments, and oscillators. These topics are supported with introductory network theory and physics. This volume is comprised of nine chapters and begins by explaining the operation of resistive, inductive, and capacitive elements in direct and alternating current circuits. The theory for some of the expressions quoted in later chapters is presented. Th

  7. Circuits and filters handbook

    CERN Document Server

    Chen, Wai-Kai

    2003-01-01

    A bestseller in its first edition, The Circuits and Filters Handbook has been thoroughly updated to provide the most current, most comprehensive information available in both the classical and emerging fields of circuits and filters, both analog and digital. This edition contains 29 new chapters, with significant additions in the areas of computer-aided design, circuit simulation, VLSI circuits, design automation, and active and digital filters. It will undoubtedly take its place as the engineer's first choice in looking for solutions to problems encountered in the design, analysis, and behavi

  8. MOS integrated circuit design

    CERN Document Server

    Wolfendale, E

    2013-01-01

    MOS Integral Circuit Design aims to help in the design of integrated circuits, especially large-scale ones, using MOS Technology through teaching of techniques, practical applications, and examples. The book covers topics such as design equation and process parameters; MOS static and dynamic circuits; logic design techniques, system partitioning, and layout techniques. Also featured are computer aids such as logic simulation and mask layout, as well as examples on simple MOS design. The text is recommended for electrical engineers who would like to know how to use MOS for integral circuit desi

  9. Security electronics circuits manual

    CERN Document Server

    MARSTON, R M

    1998-01-01

    Security Electronics Circuits Manual is an invaluable guide for engineers and technicians in the security industry. It will also prove to be a useful guide for students and experimenters, as well as providing experienced amateurs and DIY enthusiasts with numerous ideas to protect their homes, businesses and properties.As with all Ray Marston's Circuits Manuals, the style is easy-to-read and non-mathematical, with the emphasis firmly on practical applications, circuits and design ideas. The ICs and other devices used in the practical circuits are modestly priced and readily available ty

  10. Microfluidic technologies for studying synthetic circuits.

    Science.gov (United States)

    Lin, Benjamin; Levchenko, Andre

    2012-08-01

    Advances in synthetic biology have augmented the available toolkit of biomolecular modules, allowing engineering and manipulation of signaling in a variety of organisms, ranging in complexity from single bacteria and eukaryotic cells to multi-cellular systems. The richness of synthetic circuit outputs can be dramatically enhanced by sophisticated environmental control systems designed to precisely pattern spatial-temporally heterogeneous environmental stimuli controlling these circuits. Moreover, the performance of the synthetic modules and 'blocks' needed to assemble more complicated networks requires more complete characterization as a function of arbitrarily complex environmental inputs. Microfluidic technologies are poised to meet these needs through a variety of innovative designs capitalizing on the unique benefits of manipulating fluids on the micro-scales and nano-scales. This review discusses the utility of microfluidics for the study of synthetic circuits and highlights recent work in the area.

  11. Synchronizing Hyperchaotic Circuits

    DEFF Research Database (Denmark)

    Tamasevicius, Arunas; Cenys, Antanas; Namajunas, Audrius;

    1997-01-01

    Regarding possible applications to secure communications the technique of synchronizing hyperchaotic circuits with a single dynamical variable is discussed. Several specific examples including the fourth-order circuits with two positive Lyapunov exponents as well as the oscillator with a delay line...

  12. A Virtual Circuits Lab

    Science.gov (United States)

    Vick, Matthew E.

    2010-01-01

    The University of Colorado's Physics Education Technology (PhET) website offers free, high-quality simulations of many physics experiments that can be used in the classroom. The Circuit Construction Kit, for example, allows students to safely and constructively play with circuit components while learning the mathematics behind many circuit…

  13. Genetic circuit design automation.

    Science.gov (United States)

    Nielsen, Alec A K; Der, Bryan S; Shin, Jonghyeon; Vaidyanathan, Prashant; Paralanov, Vanya; Strychalski, Elizabeth A; Ross, David; Densmore, Douglas; Voigt, Christopher A

    2016-04-01

    Computation can be performed in living cells by DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. We describe a design environment, Cello, in which a user writes Verilog code that is automatically transformed into a DNA sequence. Algorithms build a circuit diagram, assign and connect gates, and simulate performance. Reliable circuit design requires the insulation of gates from genetic context, so that they function identically when used in different circuits. We used Cello to design 60 circuits forEscherichia coli(880,000 base pairs of DNA), for which each DNA sequence was built as predicted by the software with no additional tuning. Of these, 45 circuits performed correctly in every output state (up to 10 regulators and 55 parts), and across all circuits 92% of the output states functioned as predicted. Design automation simplifies the incorporation of genetic circuits into biotechnology projects that require decision-making, control, sensing, or spatial organization.

  14. Microtubule as nanobioelectronic nonlinear circuit

    Directory of Open Access Journals (Sweden)

    Sekulić Dalibor L.

    2012-01-01

    Full Text Available In recent years, the use of biological molecules has offered exciting alternatives to conventional synthetic methods. Specific methods use various biological templates to direct the deposition and patterning of inorganic materials. Here we have established a new electrical model of microtubules as a biological nanoscale circuit based on polyelectrolyte features of cylindrical biopolymers. Our working hypothesis is that microtubules play an active role in sub-cellular computation and signaling via electronic and protonic conductivity and can thus be made useful in hybrid materials that offer novel electronic characteristics. We verify these hypotheses both computationally and analytically through a quantitative model based on the atomic resolution structures of the key functional proteins.

  15. Automation Hooks Architecture for Flexible Test Orchestration - Concept Development and Validation

    Science.gov (United States)

    Lansdowne, C. A.; Maclean, John R.; Winton, Chris; McCartney, Pat

    2011-01-01

    The Automation Hooks Architecture Trade Study for Flexible Test Orchestration sought a standardized data-driven alternative to conventional automated test programming interfaces. The study recommended composing the interface using multicast DNS (mDNS/SD) service discovery, Representational State Transfer (Restful) Web Services, and Automatic Test Markup Language (ATML). We describe additional efforts to rapidly mature the Automation Hooks Architecture candidate interface definition by validating it in a broad spectrum of applications. These activities have allowed us to further refine our concepts and provide observations directed toward objectives of economy, scalability, versatility, performance, severability, maintainability, scriptability and others.

  16. Approximate circuits for increased reliability

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-12-22

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  17. Approximate circuits for increased reliability

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Jason R.; Mayo, Jackson R.

    2015-08-18

    Embodiments of the invention describe a Boolean circuit having a voter circuit and a plurality of approximate circuits each based, at least in part, on a reference circuit. The approximate circuits are each to generate one or more output signals based on values of received input signals. The voter circuit is to receive the one or more output signals generated by each of the approximate circuits, and is to output one or more signals corresponding to a majority value of the received signals. At least some of the approximate circuits are to generate an output value different than the reference circuit for one or more input signal values; however, for each possible input signal value, the majority values of the one or more output signals generated by the approximate circuits and received by the voter circuit correspond to output signal result values of the reference circuit.

  18. Troubleshooting analog circuits

    CERN Document Server

    Pease, Robert A

    1991-01-01

    Troubleshooting Analog Circuits is a guidebook for solving product or process related problems in analog circuits. The book also provides advice in selecting equipment, preventing problems, and general tips. The coverage of the book includes the philosophy of troubleshooting; the modes of failure of various components; and preventive measures. The text also deals with the active components of analog circuits, including diodes and rectifiers, optically coupled devices, solar cells, and batteries. The book will be of great use to both students and practitioners of electronics engineering. Other

  19. Modern TTL circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Modern TTL Circuits Manual provides an introduction to the basic principles of Transistor-Transistor Logic (TTL). This book outlines the major features of the 74 series of integrated circuits (ICs) and introduces the various sub-groups of the TTL family.Organized into seven chapters, this book begins with an overview of the basics of digital ICs. This text then examines the symbology and mathematics of digital logic. Other chapters consider a variety of topics, including waveform generator circuitry, clocked flip-flop and counter circuits, special counter/dividers, registers, data latches, com

  20. Plasmonic Nanoguides and Circuits

    CERN Document Server

    Bozhevolnyi, Sergey

    2008-01-01

    Modern communication systems dealing with huge amounts of data at ever increasing speed try to utilize the best aspects of electronic and optical circuits. Electronic circuits are tiny but their operation speed is limited, whereas optical circuits are extremely fast but their sizes are limited by diffraction. Waveguide components utilizing surface plasmon (SP) modes were found to combine the huge optical bandwidth and compactness of electronics, and plasmonics thereby began to be considered as the next chip-scale technology. In this book, the authors concentrate on the SP waveguide configurati

  1. Pragmatic circuits frequency domain

    CERN Document Server

    Eccles, William

    2006-01-01

    Pragmatic Circuits: Frequency Domain goes through the Laplace transform to get from the time domain to topics that include the s-plane, Bode diagrams, and the sinusoidal steady state. This second of three volumes ends with a-c power, which, although it is just a special case of the sinusoidal steady state, is an important topic with unique techniques and terminology. Pragmatic Circuits: Frequency Domain is focused on the frequency domain. In other words, time will no longer be the independent variable in our analysis. The two other volumes in the Pragmatic Circuits series include titles on DC

  2. Optoelectronics circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Optoelectronics Circuits Manual covers the basic principles and characteristics of the best known types of optoelectronic devices, as well as the practical applications of many of these optoelectronic devices. The book describes LED display circuits and LED dot- and bar-graph circuits and discusses the applications of seven-segment displays, light-sensitive devices, optocouplers, and a variety of brightness control techniques. The text also tackles infrared light-beam alarms and multichannel remote control systems. The book provides practical user information and circuitry and illustrations.

  3. Circuit analysis with Multisim

    CERN Document Server

    Baez-Lopez, David

    2011-01-01

    This book is concerned with circuit simulation using National Instruments Multisim. It focuses on the use and comprehension of the working techniques for electrical and electronic circuit simulation. The first chapters are devoted to basic circuit analysis.It starts by describing in detail how to perform a DC analysis using only resistors and independent and controlled sources. Then, it introduces capacitors and inductors to make a transient analysis. In the case of transient analysis, it is possible to have an initial condition either in the capacitor voltage or in the inductor current, or bo

  4. Monolithic microwave integrated circuits

    Science.gov (United States)

    Pucel, R. A.

    Monolithic microwave integrated circuits (MMICs), a new microwave technology which is expected to exert a profound influence on microwave circuit designs for future military systems as well as for the commercial and consumer markets, is discussed. The book contains an historical discussion followed by a comprehensive review presenting the current status in the field. The general topics of the volume are: design considerations, materials and processing considerations, monolithic circuit applications, and CAD, measurement, and packaging techniques. All phases of MMIC technology are covered, from design to testing.

  5. Innovative devices for integrated circuits - A design perspective

    Science.gov (United States)

    Schmitt-Landsiedel, D.; Werner, C.

    2009-04-01

    MOS devices go 3D, new quantum effect devices appear in the research labs. This paper discusses the impact of various innovative device architectures on circuit design. Examples of circuits with FinFETs or Multi-Gate-FETs are shown and their performance is compared with classically scaled CMOS circuits both for digital and analog applications. As an example for novel quantum effect devices beyond CMOS we discuss circuits with Tunneling Field Effect Transistors and their combination with classical MOSFETs and MuGFETs. Finally the potential of more substantial paradigm changes in circuit design will be exploited for the example of magnetic quantum cellular automata using a novel integrated magnetic field clocking scheme.

  6. Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity.

    Science.gov (United States)

    Li, Fangjun; Cheng, Cheng; Cui, Fuhao; de Oliveira, Marcos V V; Yu, Xiao; Meng, Xiangzong; Intorne, Aline C; Babilonia, Kevin; Li, Maoying; Li, Bo; Chen, Sixue; Ma, Xianfeng; Xiao, Shunyuan; Zheng, Yi; Fei, Zhangjun; Metz, Richard P; Johnson, Charles D; Koiwa, Hisashi; Sun, Wenxian; Li, Zhaohu; de Souza Filho, Gonçalo A; Shan, Libo; He, Ping

    2014-12-10

    Perception of microbe-associated molecular patterns (MAMPs) elicits host transcriptional reprogramming as part of the immune response. Although pathogen perception is well studied, the signaling networks orchestrating immune gene expression remain less clear. In a genetic screen for components involved in the early immune gene transcription reprogramming, we identified Arabidopsis RNA polymerase II C-terminal domain (CTD) phosphatase-like 3 (CPL3) as a negative regulator of immune gene expression. MAMP perception induced rapid and transient cyclin-dependent kinase C (CDKC)-mediated phosphorylation of Arabidopsis CTD. The CDKCs, which are in turn phosphorylated and activated by a canonical MAP kinase (MAPK) cascade, represent a point of signaling convergence downstream of multiple immune receptors. CPL3 directly dephosphorylated CTD to counteract MAPK-mediated CDKC regulation. Thus, modulation of the phosphorylation dynamics of eukaryotic RNA polymerase II transcription machinery by MAPKs, CTD kinases, and phosphatases constitutes an essential mechanism for rapid orchestration of host immune gene expression and defense upon pathogen attacks.

  7. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins.

    Science.gov (United States)

    Ringrose, Leonie; Paro, Renato

    2004-01-01

    During the development of multicellular organisms, cells become different from one another by changing their genetic program in response to transient stimuli. Long after the stimulus is gone, "cellular memory" mechanisms enable cells to remember their chosen fate over many cell divisions. The Polycomb and Trithorax groups of proteins, respectively, work to maintain repressed or active transcription states of developmentally important genes through many rounds of cell division. Here we review current ideas on the protein and DNA components of this transcriptional memory system and how they interact dynamically with each other to orchestrate cellular memory for several hundred genes.

  8. Latching overcurrent circuit breaker

    Science.gov (United States)

    Moore, M. L.

    1970-01-01

    Circuit breaker consists of a preset current amplitude sensor, and a lamp-photo-resistor combination in a feedback arrangement which energizes a power switching relay. The ac input power is removed from the load at predetermined current amplitudes.

  9. High temperature circuit breaker

    Science.gov (United States)

    Edwards, R. N.; Travis, E. F.

    1970-01-01

    Alternating current circuit breaker is suitable for reliable long-term service at 1000 deg F in the vacuum conditions of outer space. Construction materials are resistant to nuclear radiation and vacuum welding. Service test conditions and results are given.

  10. Overriding Faulty Circuit Breakers

    Science.gov (United States)

    Robbins, Richard L.; Pierson, Thomas E.

    1987-01-01

    Retainer keeps power on in emergency. Simple mechanical device attaches to failed aircraft-type push/pull circuit breaker to restore electrical power temporarily until breaker replaced. Device holds push/pull button in closed position; unnecessary for crewmember to hold button in position by continual finger pressure. Sleeve and plug hold button in, overriding mechanical failure in circuit breaker. Windows in sleeve show button position.

  11. Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors: an immunological and regulatory challenge.

    Science.gov (United States)

    de Witte, Moniek A; Kierkels, Guido J J; Straetemans, Trudy; Britten, Cedrik M; Kuball, Jürgen

    2015-07-01

    Over half a century ago, the first allogeneic stem cell transplantation (allo-SCT) initiated cellular immunotherapy. For several decades, little progress was made, and toxicity of allo-SCT remained a major challenge. However, recent breakthroughs have opened new avenues to further develop this modality and to provide less toxic and equally efficient interventions for patients suffering from hematological or solid malignancies. Current novel cellular immune interventions include ex vivo expansion and adoptive transfer of tumor-infiltrating immune cells or administration of drugs which antagonize tolerizing mechanisms. Alternatively, transfer of immune cells engineered to express defined T cell receptors (TCRs) and chimeric antigen receptors (CARs) has shown its potential. A valuable addition to 'engineered' adaptive immunity has emerged recently through the improved understanding of how innate immune cells can attack cancer cells without substantial side effects. This has enabled the development of transplantation platforms with limited side effects allowing early immune interventions as well as the design of engineered immune cells expressing innate immune receptors. Here, we focus on innate immune interventions and their orchestration with TCR- and CAR-engineered immune cells. In addition, we discuss how the exploitation of the full potential of cellular immune interventions is influenced by regulatory frameworks. Finally, we highlight and discuss substantial differences in the current landscape of clinical trials in Europe as compared to the USA. The aim is to stimulate international efforts to support regulatory authorities and funding agencies, especially in Europe, to create an environment that will endorse the development of engineered immune cells for the benefit of patients.

  12. Circuit simulation: some humbling thoughts

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, Manfred; /Fermilab

    2006-01-01

    A short, very personal note on circuit simulation is presented. It does neither include theoretical background on circuit simulation, nor offers an overview of available software, but just gives some general remarks for a discussion on circuit simulator needs in context to the design and development of accelerator beam instrumentation circuits and systems.

  13. Robust design of biological circuits: evolutionary systems biology approach.

    Science.gov (United States)

    Chen, Bor-Sen; Hsu, Chih-Yuan; Liou, Jing-Jia

    2011-01-01

    Artificial gene circuits have been proposed to be embedded into microbial cells that function as switches, timers, oscillators, and the Boolean logic gates. Building more complex systems from these basic gene circuit components is one key advance for biologic circuit design and synthetic biology. However, the behavior of bioengineered gene circuits remains unstable and uncertain. In this study, a nonlinear stochastic system is proposed to model the biological systems with intrinsic parameter fluctuations and environmental molecular noise from the cellular context in the host cell. Based on evolutionary systems biology algorithm, the design parameters of target gene circuits can evolve to specific values in order to robustly track a desired biologic function in spite of intrinsic and environmental noise. The fitness function is selected to be inversely proportional to the tracking error so that the evolutionary biological circuit can achieve the optimal tracking mimicking the evolutionary process of a gene circuit. Finally, several design examples are given in silico with the Monte Carlo simulation to illustrate the design procedure and to confirm the robust performance of the proposed design method. The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise.

  14. Digital and analog gene circuits for biotechnology.

    Science.gov (United States)

    Roquet, Nathaniel; Lu, Timothy K

    2014-05-01

    Biotechnology offers the promise of valuable chemical production via microbial processing of renewable and inexpensive substrates. Thus far, static metabolic engineering strategies have enabled this field to advance industrial applications. However, the industrial scaling of statically engineered microbes inevitably creates inefficiencies due to variable conditions present in large-scale microbial cultures. Synthetic gene circuits that dynamically sense and regulate different molecules can resolve this issue by enabling cells to continuously adapt to variable conditions. These circuits also have the potential to enable next-generation production programs capable of autonomous transitioning between steps in a bioprocess. Here, we review the design and application of two main classes of dynamic gene circuits, digital and analog, for biotechnology. Within the context of these classes, we also discuss the potential benefits of digital-analog interconversion, memory, and multi-signal integration. Though synthetic gene circuits have largely been applied for cellular computation to date, we envision that utilizing them in biotechnology will enhance the efficiency and scope of biochemical production with living cells.

  15. A semiconductor laser excitation circuit

    Energy Technology Data Exchange (ETDEWEB)

    Kaadzunari, O.; Masaty, K.

    1984-03-27

    A semiconductor laser excitation circuit is patented that is designed for operation in a pulsed mode with a high pulse repetition frequency. This circuit includes, in addition to a semiconductor laser, a high speed photodetector, a reference voltage source, a comparator, and a pulse oscillator and modulator. If the circuit is built using standard silicon integrated circuits, its speed amounts to several hundred megahertz, if it is constructed using gallium arsenide integrated circuits, its speed is several gigahertz.

  16. Engineering robust and tunable spatial structures with synthetic gene circuits.

    Science.gov (United States)

    Kong, Wentao; Blanchard, Andrew E; Liao, Chen; Lu, Ting

    2017-01-25

    Controllable spatial patterning is a major goal for the engineering of biological systems. Recently, synthetic gene circuits have become promising tools to achieve the goal; however, they need to possess both functional robustness and tunability in order to facilitate future applications. Here we show that, by harnessing the dual signaling and antibiotic features of nisin, simple synthetic circuits can direct Lactococcus lactis populations to form programmed spatial band-pass structures that do not require fine-tuning and are robust against environmental and cellular context perturbations. Although robust, the patterns are highly tunable, with their band widths specified by the external nisin gradient and cellular nisin immunity. Additionally, the circuits can direct cells to consistently generate designed patterns, even when the gradient is driven by structured nisin-producing bacteria and the patterning cells are composed of multiple species. A mathematical model successfully reproduces all of the observed patterns. Furthermore, the circuits allow us to establish predictable structures of synthetic communities and controllable arrays of cellular stripes and spots in space. This study offers new synthetic biology tools to program spatial structures. It also demonstrates that a deep mining of natural functionalities of living systems is a valuable route to build circuit robustness and tunability.

  17. The Mind Grows Circuits

    CERN Document Server

    Panigrahy, Rina

    2012-01-01

    There is a vast supply of prior art that study models for mental processes. Some studies in psychology and philosophy approach it from an inner perspective in terms of experiences and percepts. Others such as neurobiology or connectionist-machines approach it externally by viewing the mind as complex circuit of neurons where each neuron is a primitive binary circuit. In this paper, we also model the mind as a place where a circuit grows, starting as a collection of primitive components at birth and then builds up incrementally in a bottom up fashion. A new node is formed by a simple composition of prior nodes when we undergo a repeated experience that can be described by that composition. Unlike neural networks, however, these circuits take "concepts" or "percepts" as inputs and outputs. Thus the growing circuits can be likened to a growing collection of lambda expressions that are built on top of one another in an attempt to compress the sensory input as a heuristic to bound its Kolmogorov Complexity.

  18. Search and Orchestration of Data and Processes in a Federated Environment

    Science.gov (United States)

    Siao Him Fa, J.; Reed, T. W.; Tan, C.; West, G.; McMeekin, D. A.; Moncrieff, S.; Cox, S.

    2015-06-01

    This paper describes on-going research on streamlining the access and use of spatial data and processes in Australia. Spatial data in Australia is available on-line at many levels of government from local authorities, state and territories (jurisdictions), and nationally from the Commonwealth and other sources. Much of this data is available via Open Geospatial Consortium and World Wide Web Consortium standard web services. This abstract discusses three related research topics that have been identified by a wide range of stakeholders through a comprehensive consultation process. These are search and discovery, federation and orchestration of data and processes. The commonality across the three research topics is that they all require Semantic Web and Artificial Intelligence methods and embrace the various standards, and if needed, propose modifications to such standards.

  19. HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche

    Science.gov (United States)

    Gregori, Silvia; Amodio, Giada; Quattrone, Federica; Panina-Bordignon, Paola

    2015-01-01

    Extravillous trophoblasts (EVTs) play a central role in educating maternal leukocytes, endometrial stromal and endothelial cells to generate a receptive decidual microenvironment tailored to accept the semi-allogeneic fetus. HLA-G, a non-classical HLA class I molecule endowed with immune-regulatory functions, is primarily expressed on EVTs lining the placenta and on the naturally occurring tolerogenic dendritic cells, named DC-10, which are enriched in the human first trimester decidua. Decidual DC-10 are involved in HLA-G-mediated tolerance at the maternal–fetal interface. EVTs not only establish a tolerogenic microenvironment through the interaction with maternal innate and adaptive cells but also orchestrate placenta vascular and tissue remodeling, leading to a successful pregnancy. Here, we discuss the potential implications of the HLA-G-mediated cross-talk among the cells present at the maternal–fetal interface, and its role in maintaining a positive relationship between the mother and the fetus. PMID:25870595

  20. Management of natural crises with choreography and orchestration of federated warning-systems

    Science.gov (United States)

    Haener, Rainer; Waechter, Joachim; Hammitzsch, Martin

    2013-04-01

    The project Collaborative, Complex and Critical Decision-Support in Evolving Crises (TRIDEC), co-funded by the European Commission in its Seventh Framework Programme focuses on real-time intelligent information management in earth management. The addressed challenges include the design and implementation of a robust and scalable service infrastructure supporting the integration of existing resources, components and systems. Key challenge for TRIDEC is establishing a network of independent systems, cooperatively interacting as a collective in a system-of-systems (SoS). For this purpose TRIDEC adopts enhancements of service-oriented architecture (SOA) principles in terms of an event-driven architecture (EDA) design (SOA 2.0). In this way TRIDEC establishes large-scale concurrent and intelligent information management of a manifold of crisis types by focusing on the integration of autonomous, task-oriented and geographically distributed systems. To this end TRIDEC adapts both ways SOA 2.0 offers: orchestration and choreography. In orchestration, a central knowledge-based processing framework takes control over the involved services and coordinates their execution. Choreography on the other hand avoids central coordination. Rather, each system involved in the SoS follows a global scenario without a single point of control but specifically defined (enacted, agreed upon) trigger conditions. More than orchestration choreography allows collaborative business processes of various heterogeneous sub-systems (e.g. cooperative decision making) by concurrent Complex Event Processing (CEP) and asynchronous communication. These types of interaction adapt the concept of decoupled relationships between information producers (e.g. sensors and sensor systems) and information consumers (e.g. warning systems and warning dissemination systems). Asynchronous communication is useful if a participant wants to trigger specific actions by delegating the responsibility (separation of concerns

  1. FAST: A fully asynchronous and status-tracking pattern for geoprocessing services orchestration

    Science.gov (United States)

    Wu, Huayi; You, Lan; Gui, Zhipeng; Gao, Shuang; Li, Zhenqiang; Yu, Jingmin

    2014-09-01

    Geoprocessing service orchestration (GSO) provides a unified and flexible way to implement cross-application, long-lived, and multi-step geoprocessing service workflows by coordinating geoprocessing services collaboratively. Usually, geoprocessing services and geoprocessing service workflows are data and/or computing intensive. The intensity feature may make the execution process of a workflow time-consuming. Since it initials an execution request without blocking other interactions on the client side, an asynchronous mechanism is especially appropriate for GSO workflows. Many critical problems remain to be solved in existing asynchronous patterns for GSO including difficulties in improving performance, status tracking, and clarifying the workflow structure. These problems are a challenge when orchestrating performance efficiency, making statuses instantly available, and constructing clearly structured GSO workflows. A Fully Asynchronous and Status-Tracking (FAST) pattern that adopts asynchronous interactions throughout the whole communication tier of a workflow is proposed for GSO. The proposed FAST pattern includes a mechanism that actively pushes the latest status to clients instantly and economically. An independent proxy was designed to isolate the status tracking logic from the geoprocessing business logic, which assists the formation of a clear GSO workflow structure. A workflow was implemented in the FAST pattern to simulate the flooding process in the Poyang Lake region. Experimental results show that the proposed FAST pattern can efficiently tackle data/computing intensive geoprocessing tasks. The performance of all collaborative partners was improved due to the asynchronous mechanism throughout communication tier. A status-tracking mechanism helps users retrieve the latest running status of a GSO workflow in an efficient and instant way. The clear structure of the GSO workflow lowers the barriers for geospatial domain experts and model designers to

  2. Brain Reward Circuits in Morphine Addiction

    Science.gov (United States)

    Kim, Juhwan; Ham, Suji; Hong, Heeok; Moon, Changjong; Im, Heh-In

    2016-01-01

    Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate’s innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse. To understand the addictive properties of morphine, past studies have focused on relevant molecular and cellular changes in the brain, highlighting the functional roles of reward-related brain regions. Given the accumulated findings, a recent, emerging trend in morphine research is that of examining the dynamics of neuronal interactions in brain reward circuits under the influence of morphine action. In this review, we highlight recent findings on the roles of several reward circuits involved in morphine addiction based on pharmacological, molecular and physiological evidences. PMID:27506251

  3. Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

    NARCIS (Netherlands)

    Jaitin, Diego Adhemar; Weiner, Assaf; Yofe, Ido; Lara-Astiaso, David; Keren-Shaul, Hadas; David, Eyal; Salame, Tomer Meir; Tanay, Amos; van Oudenaarden, Alexander; Amit, Ido

    2016-01-01

    In multicellular organisms, dedicated regulatory circuits control cell type diversity and responses. The crosstalk and redundancies within these circuits and substantial cellular heterogeneity pose a major research challenge. Here, we present CRISP-seq, an integrated method for massively parallel si

  4. Genetic Redundancies Enhance Information Transfer in Noisy Regulatory Circuits

    Science.gov (United States)

    Rodrigo, Guillermo; Poyatos, Juan F.

    2016-01-01

    Cellular decision making is based on regulatory circuits that associate signal thresholds to specific physiological actions. This transmission of information is subjected to molecular noise what can decrease its fidelity. Here, we show instead how such intrinsic noise enhances information transfer in the presence of multiple circuit copies. The result is due to the contribution of noise to the generation of autonomous responses by each copy, which are altogether associated with a common decision. Moreover, factors that correlate the responses of the redundant units (extrinsic noise or regulatory cross-talk) contribute to reduce fidelity, while those that further uncouple them (heterogeneity within the copies) can lead to stronger information gain. Overall, our study emphasizes how the interplay of signal thresholding, redundancy, and noise influences the accuracy of cellular decision making. Understanding this interplay provides a basis to explain collective cell signaling mechanisms, and to engineer robust decisions with noisy genetic circuits. PMID:27741249

  5. Siim Nestor soovitab : Bell Orchestre. DJ Deep ja TRL. Akrobatik ja MC Mr.Lif. Black Dice / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2008-01-01

    Muusikaüritustest: Kanada post-rock ansambel Bell Orchestre12. sept. Tallinnas klubis Juuksur, DJ Deep 12. sept. Tallinna Linnahalli ruumides Plektrumi klubiööl (vt. www.plektrumfestival.ee), Akrobatik ja Mr.Lif 12. sept. Tartus klubis Illusion, New Yorgi kollektiiv Black Dice 17. sept. Tallinnas Von Krahlis

  6. Chaotic memristive circuit: equivalent circuit realization and dynamical analysis

    Institute of Scientific and Technical Information of China (English)

    Bao Bo-Cheng; Xu Jian-Ping; Zhou Guo-Hua; Ma Zheng-Hua; Zou Ling

    2011-01-01

    In this paper,a practical equivalent circuit of an active flux-controlled memristor characterized by smooth piecewise-quadratic nonlinearity is designed and an experimental chaotic memristive circuit is implemented.The chaotic memristive circuit has an equilibrium set and its stability is dependent on the initial state of the memristor.The initial state-dependent and the circuit parameter-dependent dynamics of the chaotic memristive circuit are investigated via phase portraits,bifurcation diagrams and Lyapunov exponents.Both experimental and simulation results validate the proposed equivalent circuit realization of the active flux-controlled memristor.

  7. Primer printed circuit boards

    CERN Document Server

    Argyle, Andrew

    2009-01-01

    Step-by-step instructions for making your own PCBs at home. Making your own printed circuit board (PCB) might seem a daunting task, but once you master the steps, it's easy to attain professional-looking results. Printed circuit boards, which connect chips and other components, are what make almost all modern electronic devices possible. PCBs are made from sheets of fiberglass clad with copper, usually in multiplelayers. Cut a computer motherboard in two, for instance, and you'll often see five or more differently patterned layers. Making boards at home is relatively easy

  8. Current Conveyor Equivalent Circuits

    Directory of Open Access Journals (Sweden)

    Tejmal S. Rathore

    2012-02-01

    Full Text Available An equivalence between a class of (current conveyor CC II+ and CC II- circuits is established. CC IIequivalent circuit uses one extra element. However, under certain condition, the extra element can be eliminated. As an illustration of the application of this equivalence, minimal first and second order all-pass filters are derived. Incertain cases, it is possible to compensate the effect of the input resistor of CC at port X. At the end, an open problem of realizing an Nth order (N > 2 minimal all-pass filter is stated.

  9. Inrush Current Control Circuit

    Science.gov (United States)

    Cole, Steven W. (Inventor)

    2002-01-01

    An inrush current control circuit having an input terminal connected to a DC power supply and an output terminal connected to a load capacitor limits the inrush current that charges up the load capacitor during power up of a system. When the DC power supply applies a DC voltage to the input terminal, the inrush current control circuit produces a voltage ramp at the load capacitor instead of an abrupt DC voltage. The voltage ramp results in a constant low level current to charge up the load capacitor, greatly reducing the current drain on the DC power supply.

  10. Circuit design for reliability

    CERN Document Server

    Cao, Yu; Wirth, Gilson

    2015-01-01

    This book presents physical understanding, modeling and simulation, on-chip characterization, layout solutions, and design techniques that are effective to enhance the reliability of various circuit units.  The authors provide readers with techniques for state of the art and future technologies, ranging from technology modeling, fault detection and analysis, circuit hardening, and reliability management. Provides comprehensive review on various reliability mechanisms at sub-45nm nodes; Describes practical modeling and characterization techniques for reliability; Includes thorough presentation of robust design techniques for major VLSI design units; Promotes physical understanding with first-principle simulations.

  11. Electronic circuits fundamentals & applications

    CERN Document Server

    Tooley, Mike

    2015-01-01

    Electronics explained in one volume, using both theoretical and practical applications.New chapter on Raspberry PiCompanion website contains free electronic tools to aid learning for students and a question bank for lecturersPractical investigations and questions within each chapter help reinforce learning Mike Tooley provides all the information required to get to grips with the fundamentals of electronics, detailing the underpinning knowledge necessary to appreciate the operation of a wide range of electronic circuits, including amplifiers, logic circuits, power supplies and oscillators. The

  12. Flat Cellular (UMTS) Networks

    NARCIS (Netherlands)

    Bosch, H.G.P.; Samuel, L.G.; Mullender, S.J.; Polakos, P.; Rittenhouse, G.

    2007-01-01

    Traditionally, cellular systems have been built in a hierarchical manner: many specialized cellular access network elements that collectively form a hierarchical cellular system. When 2G and later 3G systems were designed there was a good reason to make system hierarchical: from a cost-perspective i

  13. ESD analog circuits and design

    CERN Document Server

    Voldman, Steven H

    2014-01-01

    A comprehensive and in-depth review of analog circuit layout, schematic architecture, device, power network and ESD design This book will provide a balanced overview of analog circuit design layout, analog circuit schematic development, architecture of chips, and ESD design.  It will start at an introductory level and will bring the reader right up to the state-of-the-art. Two critical design aspects for analog and power integrated circuits are combined. The first design aspect covers analog circuit design techniques to achieve the desired circuit performance. The second and main aspect pres

  14. Quantum secure circuit evaluation

    Institute of Scientific and Technical Information of China (English)

    CHEN Huanhuan; LI Bin; ZHUANG Zhenquan

    2004-01-01

    In order to solve the problem of classical secure circuit evaluation, this paper proposes a quantum approach. In this approach, the method of inserting redundant entangled particles and quantum signature has been employed to strengthen the security of the system. Theoretical analysis shows that our solution is secure against classical and quantum attacks.

  15. Superconducting Quantum Circuits

    NARCIS (Netherlands)

    Majer, J.B.

    2002-01-01

    This thesis describes a number of experiments with superconducting cir- cuits containing small Josephson junctions. The circuits are made out of aluminum islands which are interconnected with a very thin insulating alu- minum oxide layer. The connections form a Josephson junction. The current trough

  16. Bioluminescent bioreporter integrated circuit

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Michael L. (Knoxville, TN); Sayler, Gary S. (Blaine, TN); Paulus, Michael J. (Knoxville, TN)

    2000-01-01

    Disclosed are monolithic bioelectronic devices comprising a bioreporter and an OASIC. These bioluminescent bioreporter integrated circuit are useful in detecting substances such as pollutants, explosives, and heavy-metals residing in inhospitable areas such as groundwater, industrial process vessels, and battlefields. Also disclosed are methods and apparatus for environmental pollutant detection, oil exploration, drug discovery, industrial process control, and hazardous chemical monitoring.

  17. Neuronal circuits of fear extinction.

    Science.gov (United States)

    Herry, Cyril; Ferraguti, Francesco; Singewald, Nicolas; Letzkus, Johannes J; Ehrlich, Ingrid; Lüthi, Andreas

    2010-02-01

    Fear extinction is a form of inhibitory learning that allows for the adaptive control of conditioned fear responses. Although fear extinction is an active learning process that eventually leads to the formation of a consolidated extinction memory, it is a fragile behavioural state. Fear responses can recover spontaneously or subsequent to environmental influences, such as context changes or stress. Understanding the neuronal substrates of fear extinction is of tremendous clinical relevance, as extinction is the cornerstone of psychological therapy of several anxiety disorders and because the relapse of maladaptative fear and anxiety is a major clinical problem. Recent research has begun to shed light on the molecular and cellular processes underlying fear extinction. In particular, the acquisition, consolidation and expression of extinction memories are thought to be mediated by highly specific neuronal circuits embedded in a large-scale brain network including the amygdala, prefrontal cortex, hippocampus and brain stem. Moreover, recent findings indicate that the neuronal circuitry of extinction is developmentally regulated. Here, we review emerging concepts of the neuronal circuitry of fear extinction, and highlight novel findings suggesting that the fragile phenomenon of extinction can be converted into a permanent erasure of fear memories. Finally, we discuss how research on genetic animal models of impaired extinction can further our understanding of the molecular and genetic bases of human anxiety disorders.

  18. Electronic circuits and systems: A compilation. [including integrated circuits, logic circuits, varactor diode circuits, low pass filters, and optical equipment circuits

    Science.gov (United States)

    1975-01-01

    Technological information is presented electronic circuits and systems which have potential utility outside the aerospace community. Topics discussed include circuit components such as filters, converters, and integrators, circuits designed for use with specific equipment or systems, and circuits designed primarily for use with optical equipment or displays.

  19. Behavioral synthesis of asynchronous circuits

    DEFF Research Database (Denmark)

    Nielsen, Sune Fallgaard

    2005-01-01

    This thesis presents a method for behavioral synthesis of asynchronous circuits, which aims at providing a synthesis flow which uses and tranfers methods from synchronous circuits to asynchronous circuits. We move the synchronous behavioral synthesis abstraction into the asynchronous handshake...... is idle. This reduces unnecessary switching activity in the individual functional units and therefore the energy consumption of the entire circuit. A collection of behavioral synthesis algorithms have been developed allowing the designer to perform time and power constrained design space exploration...

  20. The LMT circuit and SPICE

    DEFF Research Database (Denmark)

    Lindberg, Erik; Murali, K.; Tamacevicius, Arunas

    2006-01-01

    The state equations of the LMT circuit are modeled as a dedicated analogue computer circuit and solved by means of PSpice. The nonlinear part of the system is studied. Problems with the PSpice program are presented.......The state equations of the LMT circuit are modeled as a dedicated analogue computer circuit and solved by means of PSpice. The nonlinear part of the system is studied. Problems with the PSpice program are presented....

  1. Diode, transistor & fet circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Diode, Transistor and FET Circuits Manual is a handbook of circuits based on discrete semiconductor components such as diodes, transistors, and FETS. The book also includes diagrams and practical circuits. The book describes basic and special diode characteristics, heat wave-rectifier circuits, transformers, filter capacitors, and rectifier ratings. The text also presents practical applications of associated devices, for example, zeners, varicaps, photodiodes, or LEDs, as well as it describes bipolar transistor characteristics. The transistor can be used in three basic amplifier configuration

  2. Statistical circuit design for yield improvement in CMOS circuits

    Science.gov (United States)

    Kamath, H. J.; Purviance, J. E.; Whitaker, S. R.

    1990-01-01

    This paper addresses the statistical design of CMOS integrated circuits for improved parametric yield. The work uses the Monte Carlo technique of circuit simulation to obtain an unbiased estimation of the yield. A simple graphical analysis tool, the yield factor histogram, is presented. The yield factor histograms are generated by a new computer program called SPICENTER. Using the yield factor histograms, the most sensitive circuit parameters are noted, and their nominal values are changed to improve the yield. Two basic CMOS example circuits, one analog and one digital, are chosen and their designs are 'centered' to illustrate the use of the yield factor histograms for statistical circuit design.

  3. Circuit Bodging: Atari Punk Console

    NARCIS (Netherlands)

    Allen, B.

    2009-01-01

    Circuit bodging is back! Maxwell is proud to present small, simple, but ultimately lovable little circuits to build for your own, personal pleasure. In this edition we are featuring: The Atari Punk Console. The Atari Punk Console (or APC) is a 555 timer IC based noise maker circuit. The original was

  4. Selective Manipulation of Neural Circuits.

    Science.gov (United States)

    Park, Hong Geun; Carmel, Jason B

    2016-04-01

    Unraveling the complex network of neural circuits that form the nervous system demands tools that can manipulate specific circuits. The recent evolution of genetic tools to target neural circuits allows an unprecedented precision in elucidating their function. Here we describe two general approaches for achieving circuit specificity. The first uses the genetic identity of a cell, such as a transcription factor unique to a circuit, to drive expression of a molecule that can manipulate cell function. The second uses the spatial connectivity of a circuit to achieve specificity: one genetic element is introduced at the origin of a circuit and the other at its termination. When the two genetic elements combine within a neuron, they can alter its function. These two general approaches can be combined to allow manipulation of neurons with a specific genetic identity by introducing a regulatory gene into the origin or termination of the circuit. We consider the advantages and disadvantages of both these general approaches with regard to specificity and efficacy of the manipulations. We also review the genetic techniques that allow gain- and loss-of-function within specific neural circuits. These approaches introduce light-sensitive channels (optogenetic) or drug sensitive channels (chemogenetic) into neurons that form specific circuits. We compare these tools with others developed for circuit-specific manipulation and describe the advantages of each. Finally, we discuss how these tools might be applied for identification of the neural circuits that mediate behavior and for repair of neural connections.

  5. Neuromorphic silicon neuron circuits

    Directory of Open Access Journals (Sweden)

    Giacomo eIndiveri

    2011-05-01

    Full Text Available Hardware implementations of spiking neurons can be extremely useful for a large variety of applications, ranging from high-speed modeling of large-scale neural systems to real-time behaving systems, to bidirectional brain-machine interfaces. The specific circuit solutions used to implement silicon neurons depend on the application requirements. In this paper we describe the most common building blocks and techniques used to implement these circuits, and present an overview of a wide range of neuromorphic silicon neurons, which implement different computational models, ranging from biophysically realistic and conductance based Hodgkin-Huxley models to bi-dimensional generalized adaptive Integrate and Fire models. We compare the different design methodologies used for each silicon neuron design described, and demonstrate their features with experimental results, measured from a wide range of fabricated VLSI chips.

  6. LC-Circuit Calorimetry

    CERN Document Server

    Bossen, Olaf

    2011-01-01

    We present a new type of calorimeter in which we couple an unknown heat capacity with the aid of Peltier elements to an electrical circuit. The use of an electrical inductance and an amplifier in the circuit allows us to achieve autonomous oscillations, and the measurement of the corresponding resonance frequency makes it possible to accurately measure the heat capacity with an intrinsic statistical error that decreases as ~t^{-3/2} with measuring time t, as opposed to a corresponding error ~t^{-1/2} in the conventional alternating current (a.c.) method to measure heat capacities. We have built a demonstration experiment to show the feasibility of the new technique, and we have tested it on a gadolinium sample at its transition to the ferromagnetic state.

  7. Preconditioner Circuit Analysis

    Science.gov (United States)

    2011-09-01

    ground plane and both operational amplifier terminals. The parasitic capacitances are labeled Cp1 and Cp2 in Figure 19. Figure 19. Circuit for...3.69 MHz 3.98pF 55720 5107 OV                                  (17) Cp2 = 1 pF R1 = 5107 Ω R3...circuit. The capacitor would be placed in parallel with RF to cancel the effect of Cp2 and then feedback factor will look purely resistive. Another

  8. Inkjet deposited circuit components

    Science.gov (United States)

    Bidoki, S. M.; Nouri, J.; Heidari, A. A.

    2010-05-01

    All-printed electronics as a means of achieving ultra-low-cost electronic circuits has attracted great interest in recent years. Inkjet printing is one of the most promising techniques by which the circuit components can be ultimately drawn (i.e. printed) onto the substrate in one step. Here, the inkjet printing technique was used to chemically deposit silver nanoparticles (10-200 nm) simply by ejection of silver nitrate and reducing solutions onto different substrates such as paper, PET plastic film and textile fabrics. The silver patterns were tested for their functionality to work as circuit components like conductor, resistor, capacitor and inductor. Different levels of conductivity were achieved simply by changing the printing sequence, inks ratio and concentration. The highest level of conductivity achieved by an office thermal inkjet printer (300 dpi) was 5.54 × 105 S m-1 on paper. Inkjet deposited capacitors could exhibit a capacitance of more than 1.5 nF (parallel plate 45 × 45 mm2) and induction coils displayed an inductance of around 400 µH (planar coil 10 cm in diameter). Comparison of electronic performance of inkjet deposited components to the performance of conventionally etched items makes the technique highly promising for fabricating different printed electronic devices.

  9. Digital integrated circuits

    Science.gov (United States)

    Polasek, P.; Halamik, J.

    1984-05-01

    The term semicustom designed integrated circuits denotes integrated circuits of an all purpose character in which the production of chips is completed by using one to three custom design stencil type exposure masks. This involves in most cases interconnecting masks that are used to devise the circuit function desired by the customer. Silicon plates with an all purpose gate matrix are produced up to the interconnection level and can be kept at this phase in storage, after which a customer's specific demands can be met very expediently. All purpose logic fields containing 200 logic gates on a chip and an all purpose chip to be expanded to 1,000 logic gates are discussed. The technology facilitates the devising of fast gates with a delay of approximately 5 ns and power dissipation of 1 mW. In assembly it will be possible to make use of the entire assortment of the currently used casings with 16, 18, 20, 24, 28 and 40 outlets. In addition to the development of the mentioned technology, a general methodology for design of the mentioned gate fields is currently under way.

  10. Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.

    Science.gov (United States)

    Fu, Jiang; Hsu, Wei

    2013-04-01

    A signal first arising in the dermis to initiate the development of hair follicles has been described for many decades. Wnt is the earliest signal known to be intimately involved in hair follicle induction. However, it is not clear whether the inductive signal of Wnt arises intradermally or intraepidermally. Whether Wnt acts as the first dermal signal to initiate hair follicle development also remains unclear. Here we report that Wnt production mediated by Gpr177, the mouse Wls ortholog, is essential for hair follicle induction. Gpr177, encoding a multipass transmembrane protein, regulates Wnt sorting and secretion. Cell type-specific abrogation of the signal reveals that only epidermal, but not dermal, production of Wnt is required. An intraepidermal Wnt signal is necessary and sufficient for hair follicle initiation. However, the subsequent development depends on reciprocal signaling crosstalk of epidermal and dermal cells. Wnt signals within the epidermis and dermis and crossing between the epidermis and dermis have distinct roles and specific functions in skin development. This study not only defines the cell type responsible for Wnt production, but also reveals a highly dynamic regulation of Wnt signaling at different steps of hair follicle morphogenesis. Our findings uncover a mechanism underlying hair follicle development orchestrated by the Wnt pathway.

  11. Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible

    Science.gov (United States)

    McKemmish, Laura K.; Reimers, Jeffrey R.; McKenzie, Ross H.; Mark, Alan E.; Hush, Noel S.

    2009-08-01

    Penrose and Hameroff have argued that the conventional models of a brain function based on neural networks alone cannot account for human consciousness, claiming that quantum-computation elements are also required. Specifically, in their Orchestrated Objective Reduction (Orch OR) model [R. Penrose and S. R. Hameroff, J. Conscious. Stud. 2, 99 (1995)], it is postulated that microtubules act as quantum processing units, with individual tubulin dimers forming the computational elements. This model requires that the tubulin is able to switch between alternative conformational states in a coherent manner, and that this process be rapid on the physiological time scale. Here, the biological feasibility of the Orch OR proposal is examined in light of recent experimental studies on microtubule assembly and dynamics. It is shown that the tubulins do not possess essential properties required for the Orch OR proposal, as originally proposed, to hold. Further, we consider also recent progress in the understanding of the long-lived coherent motions in biological systems, a feature critical to Orch OR, and show that no reformation of the proposal based on known physical paradigms could lead to quantum computing within microtubules. Hence, the Orch OR model is not a feasible explanation of the origin of consciousness.

  12. Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible.

    Science.gov (United States)

    McKemmish, Laura K; Reimers, Jeffrey R; McKenzie, Ross H; Mark, Alan E; Hush, Noel S

    2009-08-01

    Penrose and Hameroff have argued that the conventional models of a brain function based on neural networks alone cannot account for human consciousness, claiming that quantum-computation elements are also required. Specifically, in their Orchestrated Objective Reduction (Orch OR) model [R. Penrose and S. R. Hameroff, J. Conscious. Stud. 2, 99 (1995)], it is postulated that microtubules act as quantum processing units, with individual tubulin dimers forming the computational elements. This model requires that the tubulin is able to switch between alternative conformational states in a coherent manner, and that this process be rapid on the physiological time scale. Here, the biological feasibility of the Orch OR proposal is examined in light of recent experimental studies on microtubule assembly and dynamics. It is shown that the tubulins do not possess essential properties required for the Orch OR proposal, as originally proposed, to hold. Further, we consider also recent progress in the understanding of the long-lived coherent motions in biological systems, a feature critical to Orch OR, and show that no reformation of the proposal based on known physical paradigms could lead to quantum computing within microtubules. Hence, the Orch OR model is not a feasible explanation of the origin of consciousness.

  13. Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function

    Directory of Open Access Journals (Sweden)

    Omary Chillo

    2016-08-01

    Full Text Available The body has the capacity to compensate for an occluded artery by creating a natural bypass upon increased fluid shear stress. How this mechanical force is translated into collateral artery growth (arteriogenesis is unresolved. We show that extravasation of neutrophils mediated by the platelet receptor GPIbα and uPA results in Nox2-derived reactive oxygen radicals, which activate perivascular mast cells. These c-kit+/CXCR-4+ cells stimulate arteriogenesis by recruiting additional neutrophils as well as growth-promoting monocytes and T cells. Additionally, mast cells may directly contribute to vascular remodeling and vascular cell proliferation through increased MMP activity and by supplying growth-promoting factors. Boosting mast cell recruitment and activation effectively promotes arteriogenesis, thereby protecting tissue from severe ischemic damage. We thus find that perivascular mast cells are central regulators of shear stress-induced arteriogenesis by orchestrating leukocyte function and growth factor/cytokine release, thus providing a therapeutic target for treatment of vascular occlusive diseases.

  14. Airway Epithelial Orchestration of Innate Immune Function in Response to Virus Infection. A Focus on Asthma.

    Science.gov (United States)

    Ritchie, Andrew I; Jackson, David J; Edwards, Michael R; Johnston, Sebastian L

    2016-03-01

    Asthma is a very common respiratory condition with a worldwide prevalence predicted to increase. There are significant differences in airway epithelial responses in asthma that are of particular interest during exacerbations. Preventing exacerbations is a primary aim when treating asthma because they often necessitate unscheduled healthcare visits and hospitalizations and are a significant cause of morbidity and mortality. The most common cause of asthma exacerbations is a respiratory virus infection, of which the most likely type is rhinovirus infection. This article focuses on the role played by the epithelium in orchestrating the innate immune responses to respiratory virus infection. Recent studies show impaired bronchial epithelial cell innate antiviral immune responses, as well as augmentation of a pro-Th2 response characterized by the epithelial-derived cytokines IL-25 and IL-33, crucial in maintaining the Th2 cytokine response to virus infection in asthma. A better understanding of the mechanisms of these abnormal immune responses has the potential to lead to the development of novel therapeutic targets for virus-induced exacerbations. The aim of this article is to highlight current knowledge regarding the role of viruses and immune modulation in the asthmatic epithelium and to discuss exciting areas for future research and novel treatments.

  15. Orchestrating A/P and D/V guidance - A Wnt/Netrin tale.

    Science.gov (United States)

    Levy-Strumpf, Naomi

    2016-01-01

    While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development as well as in malignancies. In C. elegans, as in vertebrates, dorso-ventral (D/V) graded distributions of UNC-6/Netrin and antero-posterior (A/P) graded distributions of Wnts provide instructive polarity information to guide cells and axons along their respective gradients. In this commentary, I will discuss recent findings demonstrating that these 2 signaling pathways also function redundantly to regulate polarity orthogonal to the axis of their gradation. Thus, Wnt signaling components contribute to D/V polarity, while Netrin signaling components contribute to A/P polarity and their joint action collaboratively governs migratory transitions from one axis to the other. These findings pave the way to unraveling broader roles of Wnt and Netrin signaling pathways, roles that are masked due to their redundant nature, and provide a conceptually novel view of how antero-posterior and dorso-ventral guidance mechanisms are orchestrated to establish polarity in multiple biological processes.

  16. Orchestrating Radical Innovation Through Corporate Entrepreneurship: What About the Little Ones?

    DEFF Research Database (Denmark)

    Middel, Rick; Lassen, Astrid Heidemann; Timenes Laugen, Bjørge

    2009-01-01

    In spite of a growing body of knowledge on corporate entrepreneurship as well as radical innovation, there is still a lack of knowledge on how entrepreneurial behavior and its effect on radical innovation relate to smaller organizations. Smaller organizations bear particular characteristics which...... significant reasons to make use of corporate entrepreneurship in radical innovation processes. Proactivity, risk-taking and autonomy were in particular significant elements of the approach applied by the case firms to orchestrate radical innovation processes.......In spite of a growing body of knowledge on corporate entrepreneurship as well as radical innovation, there is still a lack of knowledge on how entrepreneurial behavior and its effect on radical innovation relate to smaller organizations. Smaller organizations bear particular characteristics which...... differ from those of larger organizations, and such differences can be expected to have an influence on the use of corporate entrepreneurship and the creation of radical innovation. In the paper the central problem will be the clarification of the role that corporate entrepreneurship plays...

  17. Memory CD8+ T Cells: Orchestrators and Key Players of Innate Immunity?

    Science.gov (United States)

    Lauvau, Grégoire; Goriely, Stanislas

    2016-09-01

    Over the past decades, the dichotomy between innate and adaptive immune responses has largely dominated our understanding of immunology. Upon primary encounter with microbial pathogens, differentiation of adaptive immune cells into functional effectors usually takes several days or even longer, making them contribute to host protection only late during primary infection. However, once generated, antigen-experienced T lymphocytes can persist in the organism and constitute a pool of memory cells that mediate fast and effective protection to a recall infection with the same microbial pathogen. Herein, we challenge this classical paradigm by highlighting the "innate nature" of memory CD8+ T cells. First, within the thymus or in the periphery, naïve CD8+ T cells may acquire phenotypic and functional characteristics of memory CD8+ T cells independently of challenge with foreign antigens. Second, both the "unconventional" and the "conventional" memory cells can rapidly express protective effector functions in response to sets of inflammatory cytokines and chemokines signals, independent of cognate antigen triggering. Third, memory CD8+ T cells can act by orchestrating the recruitment, activation, and licensing of innate cells, leading to broad antimicrobial states. Thus, collectively, memory CD8+ T cells may represent important actors of innate immune defenses.

  18. Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet

    Directory of Open Access Journals (Sweden)

    Marie-Eve eDumez

    2014-03-01

    Full Text Available In more than 20% of the world population, sensitization to house dust mite (HDM allergens triggers typical allergic diseases such as allergic rhinitis and asthma. Amongst the 23 mite allergen groups hitherto identified, groups 1 are cysteine proteases belonging to the papain-like family whereas groups 3, 6 and 9 are serine proteases displaying trypsin, chymotrypsin and collagenolytic activities, respectively. While these proteases are more likely to be involved in the mite digestive system, they also play critical roles in the initiation and in the chronicity of the allergic response notably through the activation of innate immune pathways. All these allergenic proteases are expressed in mite as inactive precursor form. Until recently, the exact mechanisms of their maturation into active proteases remained to be fully elucidated. Recent breakthroughs in the understanding of the activation mechanisms of mite allergenic protease precursors have highlighted an uncommon and unique maturation pathway orchestrated by group 1 proteases that tightly regulates the proteolytic activities of groups 1, 3, 6 and 9 through complex intra- or intermolecular mechanisms. This review presents and discusses the currently available knowledge of the activation mechanisms of group 1, 3, 6 and 9 allergens of Dermatophagoides pteronyssinus laying special emphasis on their localization, regulation and interconnection.

  19. Industrial Robot Programming and UPnP Services Orchestration for the Automation of Factories

    Directory of Open Access Journals (Sweden)

    A. Valera

    2012-10-01

    Full Text Available The integration of equipment and other devices built into industrial robot cells with modern Ethernet interface technologies and low‐cost mass produced devices (such as vision systems, laser scanners, force torque‐sensors, PLCs and PDAs etc. enables integrators to offer more powerful and smarter solutions. Nevertheless, the programming of all these devices efficiently requires very specific knowledge about them, such as their hardware architectures and specific programming languages as well as details about the system’s low level communication protocols. To address these issues, this paper describes and analyses the Plug‐and‐Play architecture. This is one of the most interesting service‐oriented architectures (SOAs available, which exhibits characteristics that are well adapted to industrial robotics cells. To validate their programming features and applicability, a test bed was specially designed. This provides a new graphical service orchestration which was implemented using Workflow Foundation 4 of .NET. The obtained results allowed us to verify that the use of integration schemes based on SOAs reduces the system integration time and is better adapted to industrial robotic cell system integrators.

  20. ISOMP: An Instant Service-Orchestration Mobile M2M Platform

    Directory of Open Access Journals (Sweden)

    Cholhong Im

    2016-01-01

    Full Text Available Smartphones have greater computing power than ever before, providing convenient applications to improve our lives. In general, people find it difficult to locate suitable applications and implementing new applications often requires professional skills. In this paper, we propose a new service platform that facilitates the implementation of new applications by composing prebuilt components that provide the context information of mobile devices such as location and contacts. Our platform introduces an innovative concept named context collaboration, in which smartphones exchange context information with each other, which in turn is used to deduct useful inferences. The concept is realized by instant orchestration, which assembles some components and implements a composite component. The interactive communication interface helps a mobile device to communicate with other devices using open APIs, such as SOAP and HTTP (REST. The platform also works in heterogeneous environments, for example, between Android and iOS operating systems. Throughout the platform, mobile devices can act as smart M2M machines with context awareness, enabling intelligent tasks on behalf of users. Our platform will open up a new and innovative pathway for both enhanced mobile context awareness and M2M, which is expected to be a fundamental feature of the next generation of mobile devices.

  1. Changes to the shuttle circuits

    CERN Multimedia

    GS Department

    2011-01-01

    To fit with passengers expectation, there will be some changes to the shuttle circuits as from Monday 10 October. See details on http://cern.ch/ShuttleService (on line on 7 October). Circuit No. 5 is cancelled as circuit No. 1 also stops at Bldg. 33. In order to guarantee shorter travel times, circuit No. 1 will circulate on Meyrin site only and circuit No. 2, with departures from Bldg. 33 and 500, on Prévessin site only. Site Services Section

  2. Power system with an integrated lubrication circuit

    Science.gov (United States)

    Hoff, Brian D.; Akasam, Sivaprasad; Algrain, Marcelo C.; Johnson, Kris W.; Lane, William H.

    2009-11-10

    A power system includes an engine having a first lubrication circuit and at least one auxiliary power unit having a second lubrication circuit. The first lubrication circuit is in fluid communication with the second lubrication circuit.

  3. Pulsed feedback defers cellular differentiation.

    Directory of Open Access Journals (Sweden)

    Joe H Levine

    2012-01-01

    Full Text Available Environmental signals induce diverse cellular differentiation programs. In certain systems, cells defer differentiation for extended time periods after the signal appears, proliferating through multiple rounds of cell division before committing to a new fate. How can cells set a deferral time much longer than the cell cycle? Here we study Bacillus subtilis cells that respond to sudden nutrient limitation with multiple rounds of growth and division before differentiating into spores. A well-characterized genetic circuit controls the concentration and phosphorylation of the master regulator Spo0A, which rises to a critical concentration to initiate sporulation. However, it remains unclear how this circuit enables cells to defer sporulation for multiple cell cycles. Using quantitative time-lapse fluorescence microscopy of Spo0A dynamics in individual cells, we observed pulses of Spo0A phosphorylation at a characteristic cell cycle phase. Pulse amplitudes grew systematically and cell-autonomously over multiple cell cycles leading up to sporulation. This pulse growth required a key positive feedback loop involving the sporulation kinases, without which the deferral of sporulation became ultrasensitive to kinase expression. Thus, deferral is controlled by a pulsed positive feedback loop in which kinase expression is activated by pulses of Spo0A phosphorylation. This pulsed positive feedback architecture provides a more robust mechanism for setting deferral times than constitutive kinase expression. Finally, using mathematical modeling, we show how pulsing and time delays together enable "polyphasic" positive feedback, in which different parts of a feedback loop are active at different times. Polyphasic feedback can enable more accurate tuning of long deferral times. Together, these results suggest that Bacillus subtilis uses a pulsed positive feedback loop to implement a "timer" that operates over timescales much longer than a cell cycle.

  4. Neurons and circuits for odor processing in the piriform cortex.

    Science.gov (United States)

    Bekkers, John M; Suzuki, Norimitsu

    2013-07-01

    Increased understanding of the early stages of olfaction has lead to a renewed interest in the higher brain regions responsible for forming unified 'odor images' from the chemical components detected by the nose. The piriform cortex, which is one of the first cortical destinations of olfactory information in mammals, is a primitive paleocortex that is critical for the synthetic perception of odors. Here we review recent work that examines the cellular neurophysiology of the piriform cortex. Exciting new findings have revealed how the neurons and circuits of the piriform cortex process odor information, demonstrating that, despite its superficial simplicity, the piriform cortex is a remarkably subtle and intricate neural circuit.

  5. Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

    OpenAIRE

    Barnes, Ryan; Eckert, Kristin

    2017-01-01

    Precise duplication of the human genome is challenging due to both its size and sequence complexity. DNA polymerase errors made during replication, repair or recombination are central to creating mutations that drive cancer and aging. Here, we address the regulation of human DNA polymerases, specifically how human cells orchestrate DNA polymerases in the face of stress to complete replication and maintain genome stability. DNA polymerases of the B-family are uniquely adept at accurate genome ...

  6. Memristor based startup circuit for self biased circuits

    Science.gov (United States)

    Das, Mangal; Singh, Amit Kumar; Rathi, Amit; Singhal, Sonal

    2016-04-01

    This paper presents the design of a Memristor based startup circuit for self biased circuits. Memristor has many advantages over conventional CMOS devices such as low leakage current at nanometer scale, easy to manufacture. In this work the switching characteristics of memristor is utilized. First the theoretical equations describing the switching behavior of memristor are investigated. To prove the switching capability of Memristor, a startup circuit based on memristor is proposed which uses series combination of Memristor and capacitor. Proposed circuit is compared with the previously reported MOSFET based startup circuits. Comparison of different circuits was done to validate the results. Simulation results show that memristor based circuit can attain on (I = 12.94 µA) to off state (I = 1 .2 µA) in 25 ns while the MOSFET based startup circuits take on (I = 14.19 µA) to off state (I = 1.4 µA) in more than 90 ns. The benefit comes in terms of area because the number of components used in the circuit are lesser than the conventional startup circuits.

  7. Microwave components for cellular portable radiotelephone

    Science.gov (United States)

    Muraguchi, Masahiro; Aikawa, Masayoshi

    1995-09-01

    Mobile and personal communication systems are expected to represent a huge market for microwave components in the coming years. A number of components in silicon bipolar, silicon Bi-CMOS, GaAs MESFET, HBT and HEMT are now becoming available for system application. There are tradeoffs among the competing technologies with regard to performance, cost, reliability and time-to-market. This paper describes process selection and requirements of cost and r.f. performances to microwave semiconductor components for digital cellular and cordless telephones. Furthermore, new circuit techniques which were developed by NTT are presented.

  8. Reversible quantum cellular automata

    CERN Document Server

    Schumacher, B

    2004-01-01

    We define quantum cellular automata as infinite quantum lattice systems with discrete time dynamics, such that the time step commutes with lattice translations and has strictly finite propagation speed. In contrast to earlier definitions this allows us to give an explicit characterization of all local rules generating such automata. The same local rules also generate the global time step for automata with periodic boundary conditions. Our main structure theorem asserts that any quantum cellular automaton is structurally reversible, i.e., that it can be obtained by applying two blockwise unitary operations in a generalized Margolus partitioning scheme. This implies that, in contrast to the classical case, the inverse of a nearest neighbor quantum cellular automaton is again a nearest neighbor automaton. We present several construction methods for quantum cellular automata, based on unitaries commuting with their translates, on the quantization of (arbitrary) reversible classical cellular automata, on quantum c...

  9. Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

    Directory of Open Access Journals (Sweden)

    Chi-Yun Wang

    2014-01-01

    Full Text Available Annexin A2 (ANXA2 orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.

  10. Evolution and regulation of cellular periodic processes: a role for paralogues

    DEFF Research Database (Denmark)

    Trachana, Kalliopi; Jensen, Lars Juhl; Bork, Peer

    2010-01-01

    paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms....... performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated...

  11. Photonic Integrated Circuits

    Science.gov (United States)

    Krainak, Michael; Merritt, Scott

    2016-01-01

    Integrated photonics generally is the integration of multiple lithographically defined photonic and electronic components and devices (e.g. lasers, detectors, waveguides passive structures, modulators, electronic control and optical interconnects) on a single platform with nanometer-scale feature sizes. The development of photonic integrated circuits permits size, weight, power and cost reductions for spacecraft microprocessors, optical communication, processor buses, advanced data processing, and integrated optic science instrument optical systems, subsystems and components. This is particularly critical for small spacecraft platforms. We will give an overview of some NASA applications for integrated photonics.

  12. Electronic logic circuits

    CERN Document Server

    Gibson, J

    2013-01-01

    Most branches of organizing utilize digital electronic systems. This book introduces the design of such systems using basic logic elements as the components. The material is presented in a straightforward manner suitable for students of electronic engineering and computer science. The book is also of use to engineers in related disciplines who require a clear introduction to logic circuits. This third edition has been revised to encompass the most recent advances in technology as well as the latest trends in components and notation. It includes a wide coverage of application specific integrate

  13. Electronics circuits and systems

    CERN Document Server

    Bishop, Owen

    2011-01-01

    The material in Electronics - Circuits and Systems is a truly up-to-date textbook, with coverage carefully matched to the electronics units of the 2007 BTEC National Engineering and the latest AS and A Level specifications in Electronics from AQA, OCR and WJEC. The material has been organized with a logical learning progression, making it ideal for a wide range of pre-degree courses in electronics. The approach is student-centred and includes: numerous examples and activities; web research topics; Self Test features, highlighted key facts, formulae and definitions. Ea

  14. Linear integrated circuits

    CERN Document Server

    Carr, Joseph

    1996-01-01

    The linear IC market is large and growing, as is the demand for well trained technicians and engineers who understand how these devices work and how to apply them. Linear Integrated Circuits provides in-depth coverage of the devices and their operation, but not at the expense of practical applications in which linear devices figure prominently. This book is written for a wide readership from FE and first degree students, to hobbyists and professionals.Chapter 1 offers a general introduction that will provide students with the foundations of linear IC technology. From chapter 2 onwa

  15. Optoelectronics circuits manual

    CERN Document Server

    Marston, R M

    1999-01-01

    This manual is a useful single-volume guide specifically aimed at the practical design engineer, technician, and experimenter, as well as the electronics student and amateur. It deals with the subject in an easy to read, down to earth, and non-mathematical yet comprehensive manner, explaining the basic principles and characteristics of the best known devices, and presenting the reader with many practical applications and over 200 circuits. Most of the ICs and other devices used are inexpensive and readily available types, with universally recognised type numbers.The second edition

  16. Nano integrated circuit process

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Yung Sup

    2004-02-15

    This book contains nine chapters, which are introduction of manufacture of semiconductor chip, oxidation such as Dry-oxidation, wet oxidation, oxidation model and oxide film, diffusion like diffusion process, diffusion equation, diffusion coefficient and diffusion system, ion implantation, including ion distribution, channeling, multiimplantation and masking and its system, sputtering such as CVD and PVD, lithography, wet etch and dry etch, interconnection and flattening like metal-silicon connection, silicide, multiple layer metal process and flattening, an integrated circuit process, including MOSFET and CMOS.

  17. Electronics circuits and systems

    CERN Document Server

    Bishop, Owen

    2007-01-01

    The material in Electronics - Circuits and Systems is a truly up-to-date textbook, with coverage carefully matched to the electronics units of the 2007 BTEC National Engineering and the latest AS and A Level specifications in Electronics from AQA, OCR and WJEC. The material has been organized with a logical learning progression, making it ideal for a wide range of pre-degree courses in electronics. The approach is student-centred and includes: numerous examples and activities; web research topics; Self Test features, highlighted key facts, formulae and definitions. Each chapter ends with a set

  18. Electric circuits problem solver

    CERN Document Server

    REA, Editors of

    2012-01-01

    Each Problem Solver is an insightful and essential study and solution guide chock-full of clear, concise problem-solving gems. All your questions can be found in one convenient source from one of the most trusted names in reference solution guides. More useful, more practical, and more informative, these study aids are the best review books and textbook companions available. Nothing remotely as comprehensive or as helpful exists in their subject anywhere. Perfect for undergraduate and graduate studies.Here in this highly useful reference is the finest overview of electric circuits currently av

  19. Sequential circuit design for radiation hardened multiple voltage integrated circuits

    Science.gov (United States)

    Clark, Lawrence T.; McIver, III, John K.

    2009-11-24

    The present invention includes a radiation hardened sequential circuit, such as a bistable circuit, flip-flop or other suitable design that presents substantial immunity to ionizing radiation while simultaneously maintaining a low operating voltage. In one embodiment, the circuit includes a plurality of logic elements that operate on relatively low voltage, and a master and slave latches each having storage elements that operate on a relatively high voltage.

  20. Novel Design of a Nano-metric Fast 4*4 Reversible unsigned Wallace Multiplier Circuit

    Directory of Open Access Journals (Sweden)

    Ehsan PourAliAkbar

    2015-12-01

    Full Text Available One of the most promising technologies in designing low-power circuits is reversible computing. It is used in nanotechnology, quantum computing, quantum dot cellular automata (QCA, DNA computing, optical computing and in CMOS low-power designs. Since reversible logic is subject to certain restrictions (e.g. fan-out and feedback are not allowed, traditional synthesis methods are not applicable and specific methods have been developed. In this paper, we offer a Wallace 4*4 reversible multiplier circuits which have faster speed and lower complexity in comparison with the other multiplier circuits. This circuit performs better, regarding to the number of gates, garbage outputs and constant inputs work better than the same circuits. In this paper, Peres gate is used as HA and HNG gate is used as FA. We offer the best method to multiply two 4 bit numbers. These Nano-metric circuits can be used in very complex systems.

  1. Sound Practice– Improving occupational health and safety for professional orchestral musicians in Australia

    Directory of Open Access Journals (Sweden)

    Bronwen Jane Ackermann

    2014-09-01

    Full Text Available The Sound Practice Project is a five-year study involving baseline evaluation, development and implementation of musician-specific work health and safety initiatives. A cross-sectional population physical and psychological survey and physical assessment were conducted at the same time, with an auditory health assessment conducted later. The results were used to guide the development of a series of targeted interventions, encompassing physical, psychological and auditory health components. This paper provides an overview of the project but focuses on the health findings arising from the cross-sectional survey.377 musicians from the eight professional symphony orchestras in Australia took part in the cross-sectional study (about 70% of eligible musicians. Eighty-four percent (84% of musicians reported past performance-related musculoskeletal disorder (PRMD episodes; 50% were suffering a current PRMD. Of the 63% who returned hearing surveys, 43% believed they had hearing loss, and 64% used earplugs at least intermittently. Noise exposure was found to be high in private practice, although awareness of risk and earplug use in this environment was lower than in orchestral settings. Improved strategic approaches, acoustic screens and recently developed active earplugs were found to provide effective new options for hearing protection. With respect to psychosocial screening, female musicians reported significantly more trait anxiety, music performance anxiety, social anxiety, and other forms of anxiety and depression than male musicians. The youngest musicians were significantly more anxious compared with the oldest musicians. Thirty-three percent (33% of musicians may meet criteria for a diagnosis of social phobia; 32% returned a positive depression screen and 22% for post-traumatic stress disorder. PRMDs and trigger point discomfort levels were strongly associated with increasing severity of psychological issues such as depression and music

  2. Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1.

    Science.gov (United States)

    Wang, J; Wang, C D; Zhang, N; Tong, W X; Zhang, Y F; Shan, S Z; Zhang, X L; Li, Q F

    2016-01-01

    Mechanical stimulation and histone deacetylases (HDACs) have essential roles in regulating the osteogenic differentiation of bone marrow stromal cells (BMSCs) and bone formation. However, little is known regarding what regulates HDAC expression and therefore the osteogenic differentiation of BMSCs during osteogenesis. In this study, we investigated whether mechanical loading regulates HDAC expression directly and examined the role of HDACs in mechanical loading-triggered osteogenic differentiation and bone formation. We first studied the microarrays of samples from patients with osteoporosis and found that the NOTCH pathway and skeletal development gene sets were downregulated in the BMSCs of patients with osteoporosis. Then we demonstrated that mechanical stimuli can regulate osteogenesis and bone formation both in vivo and in vitro. NOTCH signaling was upregulated during cyclic mechanical stretch (CMS)-induced osteogenic differentiation, whereas HDAC1 protein expression was downregulated. The perturbation of HDAC1 expression also had a significant effect on matrix mineralization and JAG1-mediated Notch signaling, suggesting that HDAC1 acts as an endogenous attenuator of Notch signaling in the mechanotransduction of BMSCs. Chromatin immunoprecipitation (ChIP) assay results suggest that HDAC1 modulates the CMS-induced histone H3 acetylation level at the JAG1 promoter. More importantly, we found an inhibitory role of Hdac1 in regulating bone formation in response to hindlimb unloading in mice, and pretreatment with an HDAC1 inhibitor partly rescued the osteoporosis caused by mechanical unloading. Our results demonstrate, for the first time, that mechanical stimulation orchestrates genes expression involved in the osteogenic differentiation of BMSCs via the direct regulation of HDAC1, and the therapeutic inhibition of HDAC1 may be an efficient strategy for enhancing bone formation under mechanical stimulation.

  3. Heterogeneous cellular networks

    CERN Document Server

    Hu, Rose Qingyang

    2013-01-01

    A timely publication providing coverage of radio resource management, mobility management and standardization in heterogeneous cellular networks The topic of heterogeneous cellular networks has gained momentum in industry and the research community, attracting the attention of standardization bodies such as 3GPP LTE and IEEE 802.16j, whose objectives are looking into increasing the capacity and coverage of the cellular networks. This book focuses on recent progresses,  covering the related topics including scenarios of heterogeneous network deployment, interference management i

  4. 49 CFR 236.13 - Spring switch; selection of signal control circuits through circuit controller.

    Science.gov (United States)

    2010-10-01

    ... circuits through circuit controller. 236.13 Section 236.13 Transportation Other Regulations Relating to...; selection of signal control circuits through circuit controller. The control circuits of signals governing... circuit controller, or through the contacts of relay repeating the position of such circuit...

  5. Quasi-Linear Circuit

    Science.gov (United States)

    Bradley, William; Bird, Ross; Eldred, Dennis; Zook, Jon; Knowles, Gareth

    2013-01-01

    This work involved developing spacequalifiable switch mode DC/DC power supplies that improve performance with fewer components, and result in elimination of digital components and reduction in magnetics. This design is for missions where systems may be operating under extreme conditions, especially at elevated temperature levels from 200 to 300 degC. Prior art for radiation-tolerant DC/DC converters has been accomplished utilizing classical magnetic-based switch mode converter topologies; however, this requires specific shielding and component de-rating to meet the high-reliability specifications. It requires complex measurement and feedback components, and will not enable automatic re-optimization for larger changes in voltage supply or electrical loading condition. The innovation is a switch mode DC/DC power supply that eliminates the need for processors and most magnetics. It can provide a well-regulated voltage supply with a gain of 1:100 step-up to 8:1 step down, tolerating an up to 30% fluctuation of the voltage supply parameters. The circuit incorporates a ceramic core transformer in a manner that enables it to provide a well-regulated voltage output without use of any processor components or magnetic transformers. The circuit adjusts its internal parameters to re-optimize its performance for changes in supply voltage, environmental conditions, or electrical loading at the output

  6. Automated Design of Quantum Circuits

    Science.gov (United States)

    Williams, Colin P.; Gray, Alexander G.

    2000-01-01

    In order to design a quantum circuit that performs a desired quantum computation, it is necessary to find a decomposition of the unitary matrix that represents that computation in terms of a sequence of quantum gate operations. To date, such designs have either been found by hand or by exhaustive enumeration of all possible circuit topologies. In this paper we propose an automated approach to quantum circuit design using search heuristics based on principles abstracted from evolutionary genetics, i.e. using a genetic programming algorithm adapted specially for this problem. We demonstrate the method on the task of discovering quantum circuit designs for quantum teleportation. We show that to find a given known circuit design (one which was hand-crafted by a human), the method considers roughly an order of magnitude fewer designs than naive enumeration. In addition, the method finds novel circuit designs superior to those previously known.

  7. CMOS Nonlinear Signal Processing Circuits

    OpenAIRE

    2010-01-01

    The chapter describes various nonlinear signal processing CMOS circuits, including a high reliable WTA/LTA, simple MED cell, and low-voltage arbitrary order extractor. We focus the discussion on CMOS analog circuit design with reliable, programmable capability, and low voltage operation. It is a practical problem when the multiple identical cells are required to match and realized within a single chip using a conventional process. Thus, the design of high-reliable circuit is indeed needed. Th...

  8. Analog electronic neural network circuits

    Energy Technology Data Exchange (ETDEWEB)

    Graf, H.P.; Jackel, L.D. (AT and T Bell Labs., Holmdel, NJ (USA))

    1989-07-01

    The large interconnectivity and moderate precision required in neural network models present new opportunities for analog computing. This paper discusses analog circuits for a variety of problems such as pattern matching, optimization, and learning. Most of the circuits build so far are relatively small, exploratory designs. The most mature circuits are those for template matching. Chips performing this function are now being applied to pattern recognition problems.

  9. Transistor switching and sequential circuits

    CERN Document Server

    Sparkes, John J

    1969-01-01

    Transistor Switching and Sequential Circuits presents the basic ideas involved in the construction of computers, instrumentation, pulse communication systems, and automation. This book discusses the design procedure for sequential circuits. Organized into two parts encompassing eight chapters, this book begins with an overview of the ways on how to generate the types of waveforms needed in digital circuits, principally ramps, square waves, and delays. This text then considers the behavior of some simple circuits, including the inverter, the emitter follower, and the long-tailed pair. Other cha

  10. Unstable oscillators based hyperchaotic circuit

    DEFF Research Database (Denmark)

    Murali, K.; Tamasevicius, A.; G. Mykolaitis, A.;

    1999-01-01

    A simple 4th order hyperchaotic circuit with unstable oscillators is described. The circuit contains two negative impedance converters, two inductors, two capacitors, a linear resistor and a diode. The Lyapunov exponents are presented to confirm hyperchaotic nature of the oscillations in the circ......A simple 4th order hyperchaotic circuit with unstable oscillators is described. The circuit contains two negative impedance converters, two inductors, two capacitors, a linear resistor and a diode. The Lyapunov exponents are presented to confirm hyperchaotic nature of the oscillations...

  11. Nanostructured cellular networks.

    Science.gov (United States)

    Moriarty, P; Taylor, M D R; Brust, M

    2002-12-01

    Au nanocrystals spin-coated onto silicon from toluene form cellular networks. A quantitative statistical crystallography analysis shows that intercellular correlations drive the networks far from statistical equilibrium. Spin-coating from hexane does not produce cellular structure, yet a strong correlation is retained in the positions of nanocrystal aggregates. Mechanisms based on Marangoni convection alone cannot account for the variety of patterns observed, and we argue that spinodal decomposition plays an important role in foam formation.

  12. Boosting functionality of synthetic DNA circuits with tailored deactivation.

    Science.gov (United States)

    Montagne, Kevin; Gines, Guillaume; Fujii, Teruo; Rondelez, Yannick

    2016-11-15

    Molecular programming takes advantage of synthetic nucleic acid biochemistry to assemble networks of reactions, in vitro, with the double goal of better understanding cellular regulation and providing information-processing capabilities to man-made chemical systems. The function of molecular circuits is deeply related to their topological structure, but dynamical features (rate laws) also play a critical role. Here we introduce a mechanism to tune the nonlinearities associated with individual nodes of a synthetic network. This mechanism is based on programming deactivation laws using dedicated saturable pathways. We demonstrate this approach through the conversion of a single-node homoeostatic network into a bistable and reversible switch. Furthermore, we prove its generality by adding new functions to the library of reported man-made molecular devices: a system with three addressable bits of memory, and the first DNA-encoded excitable circuit. Specific saturable deactivation pathways thus greatly enrich the functional capability of a given circuit topology.

  13. Multi-cellular logistics of collective cell migration.

    Directory of Open Access Journals (Sweden)

    Masataka Yamao

    Full Text Available During development, the formation of biological networks (such as organs and neuronal networks is controlled by multicellular transportation phenomena based on cell migration. In multi-cellular systems, cellular locomotion is restricted by physical interactions with other cells in a crowded space, similar to passengers pushing others out of their way on a packed train. The motion of individual cells is intrinsically stochastic and may be viewed as a type of random walk. However, this walk takes place in a noisy environment because the cell interacts with its randomly moving neighbors. Despite this randomness and complexity, development is highly orchestrated and precisely regulated, following genetic (and even epigenetic blueprints. Although individual cell migration has long been studied, the manner in which stochasticity affects multi-cellular transportation within the precisely controlled process of development remains largely unknown. To explore the general principles underlying multicellular migration, we focus on the migration of neural crest cells, which migrate collectively and form streams. We introduce a mechanical model of multi-cellular migration. Simulations based on the model show that the migration mode depends on the relative strengths of the noise from migratory and non-migratory cells. Strong noise from migratory cells and weak noise from surrounding cells causes "collective migration," whereas strong noise from non-migratory cells causes "dispersive migration." Moreover, our theoretical analyses reveal that migratory cells attract each other over long distances, even without direct mechanical contacts. This effective interaction depends on the stochasticity of the migratory and non-migratory cells. On the basis of these findings, we propose that stochastic behavior at the single-cell level works effectively and precisely to achieve collective migration in multi-cellular systems.

  14. A Circuit to Demonstrate Phase Relationships in "RLC" Circuits

    Science.gov (United States)

    Sokol, P. E.; Warren, G.; Zheng, B.; Smith, P.

    2013-01-01

    We have developed a circuit to demonstrate the phase relationships between resistive and reactive elements in series "RLC" circuits. We utilize a differential amplifier to allow the phases of the three elements and the current to be simultaneously displayed on an inexpensive four channel oscilloscope. We have included a novel circuit…

  15. Genetic dissection of GABAergic neural circuits in mouse neocortex

    Directory of Open Access Journals (Sweden)

    Hiroki eTaniguchi

    2014-01-01

    Full Text Available Diverse and flexible cortical functions rely on the ability of neural circuits to perform multiple types of neuronal computations. GABAergic inhibitory interneurons significantly contribute to this task by regulating the balance of activity, synaptic integration, spiking, synchrony, and oscillation in a neural ensemble. GABAergic interneruons display a high degree of cellular diversity in morphology, physiology, connectivity, and gene expression. A considerable number of subtypes of GABAergic interneurons diversify modes of cortical inhibition, enabling various types of information processing in the cortex. Thus, comprehensively understanding fate specification, circuit assembly and physiological function of GABAergic interneurons is a key to elucidate the principles of cortical wiring and function. Recent advances in genetically encoded molecular tools have made a breakthrough to systematically study cortical circuitry at the molecular, cellular, circuit, and whole animal levels. However, the biggest obstacle to fully applying the power of these to analysis of GABAergic circuits was that there were no efficient and reliable methods to express them in subtypes of GABAergic interneurons. Here, I first summarize cortical interneuron diversity and current understanding of mechanisms, by which distinct classes of GABAergic interneurons are generated. I then review recent development in genetically encoded molecular tools for neural circuit research, and genetic targeting of GABAergic interneuron subtypes, particulary focusing on our recent effort to develop and characterize Cre/CreER knockin lines. Finally, I highlight recent success in genetic targeting of chandelier cells (ChCs, the most unique and distinct GABAergic interneuron subtype, and discuss what kind of questions need to be addressed to understand development and function of cortical inhibitory circuits.

  16. VLSI circuits implementing computational models of neocortical circuits.

    Science.gov (United States)

    Wijekoon, Jayawan H B; Dudek, Piotr

    2012-09-15

    This paper overviews the design and implementation of three neuromorphic integrated circuits developed for the COLAMN ("Novel Computing Architecture for Cognitive Systems based on the Laminar Microcircuitry of the Neocortex") project. The circuits are implemented in a standard 0.35 μm CMOS technology and include spiking and bursting neuron models, and synapses with short-term (facilitating/depressing) and long-term (STDP and dopamine-modulated STDP) dynamics. They enable execution of complex nonlinear models in accelerated-time, as compared with biology, and with low power consumption. The neural dynamics are implemented using analogue circuit techniques, with digital asynchronous event-based input and output. The circuits provide configurable hardware blocks that can be used to simulate a variety of neural networks. The paper presents experimental results obtained from the fabricated devices, and discusses the advantages and disadvantages of the analogue circuit approach to computational neural modelling.

  17. A dishwasher for circuits

    CERN Multimedia

    Rosaria Marraffino

    2014-01-01

    You have always been told that electronic devices fear water. However, at the Surface Mount Devices (SMD) Workshop here at CERN all the electronic assemblies are cleaned with a machine that looks like a… dishwasher.   The circuit dishwasher. Credit: Clara Nellist.  If you think the image above shows a dishwasher, you wouldn’t be completely wrong. Apart from the fact that the whole pumping system and the case itself are made entirely from stainless steel and chemical resistant materials, and the fact that it washes electrical boards instead of dishes… it works exactly like a dishwasher. It’s a professional machine (mainly used in the pharmaceutical industry) designed to clean everything that can be washed with a water-based chemical soap. This type of treatment increases the lifetime of the electronic boards and therefore the LHC's reliability by preventing corrosion problems in the severe radiation and ozone environment of the LHC tunn...

  18. Basic electronic circuits

    CERN Document Server

    Buckley, P M

    1980-01-01

    In the past, the teaching of electricity and electronics has more often than not been carried out from a theoretical and often highly academic standpoint. Fundamentals and basic concepts have often been presented with no indication of their practical appli­ cations, and all too frequently they have been illustrated by artificially contrived laboratory experiments bearing little relationship to the outside world. The course comes in the form of fourteen fairly open-ended constructional experiments or projects. Each experiment has associated with it a construction exercise and an explanation. The basic idea behind this dual presentation is that the student can embark on each circuit following only the briefest possible instructions and that an open-ended approach is thereby not prejudiced by an initial lengthy encounter with the theory behind the project; this being a sure way to dampen enthusiasm at the outset. As the investigation progresses, questions inevitably arise. Descriptions of the phenomena encounte...

  19. Memristor Circuits and Systems

    KAUST Repository

    Zidan, Mohammed A.

    2015-05-01

    Current CMOS-based technologies are facing design challenges related to the continuous scaling down of the minimum feature size, according to Moore’s law. Moreover, conventional computing architecture is no longer an effective way of fulfilling modern applications demands, such as big data analysis, pattern recognition, and vector processing. Therefore, there is an exigent need to shift to new technologies, at both the architecture and the device levels. Recently, memristor devices and structures attracted attention for being promising candidates for this job. Memristor device adds a new dimension for designing novel circuits and systems. In addition, high-density memristor-based crossbar is widely considered to be the essential element for future memory and bio-inspired computing systems. However, numerous challenges need to be addressed before the memristor genuinely replaces current memory and computing technologies, which is the motivation behind this research effort. In order to address the technology challenges, we begin by fabricating and modeling the memristor device. The devices fabricated at our local clean room enriched our understanding of the memristive phenomenon and enabled the experimental testing for our memristor-based circuits. Moreover, our proposed mathematical modeling for memristor behavior is an essential element for the theoretical circuit design stage. Designing and addressing the challenges of memristor systems with practical complexity, however, requires an extra step, which takes the form of a reliable and modular simulation platform. We, therefore, built a new simulation platform for the resistive crossbar, which can simulate realistic size arrays filled with real memory data. In addition, this simulation platform includes various crossbar nonidealities in order to obtain accurate simulation results. Consequently, we were able to address the significant challenges facing the high density memristor crossbar, as the building block for

  20. Diamond Integrated Optomechanical Circuits

    CERN Document Server

    Rath, Patrik; Nebel, Christoph; Wild, Christoph; Pernice, Wolfram H P

    2013-01-01

    Diamond offers unique material advantages for the realization of micro- and nanomechanical resonators due to its high Young's modulus, compatibility with harsh environments and superior thermal properties. At the same time, the wide electronic bandgap of 5.45eV makes diamond a suitable material for integrated optics because of broadband transparency and the absence of free-carrier absorption commonly encountered in silicon photonics. Here we take advantage of both to engineer full-scale optomechanical circuits in diamond thin films. We show that polycrystalline diamond films fabricated by chemical vapour deposition provide a convenient waferscale substrate for the realization of high quality nanophotonic devices. Using free-standing nanomechanical resonators embedded in on-chip Mach-Zehnder interferometers, we demonstrate efficient optomechanical transduction via gradient optical forces. Fabricated diamond resonators reproducibly show high mechanical quality factors up to 11,200. Our low cost, wideband, carri...

  1. Modeling cortical circuits.

    Energy Technology Data Exchange (ETDEWEB)

    Rohrer, Brandon Robinson; Rothganger, Fredrick H.; Verzi, Stephen J.; Xavier, Patrick Gordon

    2010-09-01

    The neocortex is perhaps the highest region of the human brain, where audio and visual perception takes place along with many important cognitive functions. An important research goal is to describe the mechanisms implemented by the neocortex. There is an apparent regularity in the structure of the neocortex [Brodmann 1909, Mountcastle 1957] which may help simplify this task. The work reported here addresses the problem of how to describe the putative repeated units ('cortical circuits') in a manner that is easily understood and manipulated, with the long-term goal of developing a mathematical and algorithmic description of their function. The approach is to reduce each algorithm to an enhanced perceptron-like structure and describe its computation using difference equations. We organize this algorithmic processing into larger structures based on physiological observations, and implement key modeling concepts in software which runs on parallel computing hardware.

  2. Implications of TGFβ on transcriptome and cellular biofunctions of palatal mesenchyme

    Directory of Open Access Journals (Sweden)

    Xiujuan eZhu

    2012-04-01

    Full Text Available Development of the palate comprises sequential stages of growth, elevation and fusion of the palatal shelves. The mesenchymal component of palates plays a major role in early phases of palatogenesis, such as growth and elevation. Failure in these steps may result in cleft palate, the second most common birth defect in the world. These early stages of palatogenesis require precise and chronological orchestration of key physiological processes, such as growth, proliferation, differentiation, migration, and apoptosis. There is compelling evidence for the vital role of TGFβ-mediated regulation of palate development. We hypothesized that the isoforms of TGFβ regulate different cellular biofunctions of the palatal mesenchyme to various extents. Human embryonic palatal mesenchyme (HEPM cells were treated with TGFβ1, β2, and β3 for microarray-based gene expression studies in order to identify the roles of TGFβ in the transcriptome of the palatal mesenchyme. Following normalization and modeling of 28,869 human genes, 566 transcripts were detected as differentially expressed in TGFβ-treated HEPM cells. Out of these altered transcripts, 234 of them were clustered in cellular biofunctions, including growth and proliferation, development, morphology, movement, cell cycle, and apoptosis. Biological interpretation and network analysis of the genes active in cellular biofunctions were performed using IPA. Among the differentially expressed genes, 11 of them were previously identified as being crucial for palatogenesis (EDN1, INHBA, LHX8, PDGFC, PIGA, RUNX1, SNAI1, SMAD3, TGFβ1, TGFβ2, and TGFβR1. These genes were used for a merged interaction network with cellular behaviors. Overall, we have determined that more than 2% of human transcripts were differentially expressed in response to TGFβ treatment in HEPM cells. Our results suggest that both TGFβ1 and TGFβ2 orchestrate major cellular biofunctions within the palatal mesenchyme in vitro by

  3. Short-circuit impedance measurement

    DEFF Research Database (Denmark)

    Pedersen, Knud Ole Helgesen; Nielsen, Arne Hejde; Poulsen, Niels Kjølstad

    2003-01-01

    Methods for estimating the short-circuit impedance in the power grid are investigated for various voltage levels and situations. The short-circuit impedance is measured, preferably from naturally occurring load changes in the grid, and it is shown that such a measurement system faces different...

  4. Comminution circuits for compact itabirites

    Directory of Open Access Journals (Sweden)

    Pedro Ferreira Pinto

    Full Text Available Abstract In the beneficiation of compact Itabirites, crushing and grinding account for major operational and capital costs. As such, the study and development of comminution circuits have a fundamental importance for feasibility and optimization of compact Itabirite beneficiation. This work makes a comparison between comminution circuits for compact Itabirites from the Iron Quadrangle. The circuits developed are: a crushing and ball mill circuit (CB, a SAG mill and ball mill circuit (SAB and a single stage SAG mill circuit (SSSAG. For the SAB circuit, the use of pebble crushing is analyzed (SABC. An industrial circuit for 25 million tons of run of mine was developed for each route from tests on a pilot scale (grinding and industrial scale. The energy consumption obtained for grinding in the pilot tests was compared with that reported by Donda and Bond. The SSSAG route had the lowest energy consumption, 11.8kWh/t and the SAB route had the highest energy consumption, 15.8kWh/t. The CB and SABC routes had a similar energy consumption of 14.4 kWh/t and 14.5 kWh/t respectively.

  5. Dive In to Aquatic Circuits.

    Science.gov (United States)

    Goldfarb, Joseph M.

    1995-01-01

    The article presents a method for swimming teachers and coaches to stave off workout boredom in their students by using a circuit in the pool. After explaining how to set up a training circuit, the article describes sample stations and notes important safety precautions. (SM)

  6. Sequential Polarity-Reversing Circuit

    Science.gov (United States)

    Labaw, Clayton C.

    1994-01-01

    Proposed circuit reverses polarity of electric power supplied to bidirectional dc motor, reversible electro-mechanical actuator, or other device operating in direction depending on polarity. Circuit reverses polarity each time power turned on, without need for additional polarity-reversing or direction signals and circuitry to process them.

  7. Logic Circuit Design Selected Methods

    CERN Document Server

    Vingron, Shimon P

    2012-01-01

        In three main divisions the  book covers combinational circuits, latches, and asynchronous sequential circuits. Combinational circuits have  no memorising ability, while sequential circuits have such an ability to various degrees. Latches are the simplest sequential circuits, ones with the shortest memory. The presentation is decidedly non-standard.         The design of combinational circuits is discussed in an orthodox manner using normal forms and in an unorthodox manner using set-theoretical evaluation formulas relying heavily on Karnaugh maps. The latter approach allows for a new design technique called composition.          Latches are covered very extensively. Their memory functions are expressed mathematically in a time-independent manner allowing the use of (normal, non-temporal) Boolean logic in their calculation. The theory of latches is then used as the basis for calculating asynchronous circuits.         Asynchronous circuits are specified in a tree-representation, eac...

  8. Enhancement of Linear Circuit Program

    DEFF Research Database (Denmark)

    Gaunholt, Hans; Dabu, Mihaela; Beldiman, Octavian

    1996-01-01

    In this report a preliminary user friendly interface has been added to the LCP2 program making it possible to describe an electronic circuit by actually drawing the circuit on the screen. Component values and other options and parameters can easily be set by the aid of the interface. The interfac...

  9. Accurate Switched-Voltage voltage averaging circuit

    OpenAIRE

    金光, 一幸; 松本, 寛樹

    2006-01-01

    Abstract ###This paper proposes an accurate Switched-Voltage (SV) voltage averaging circuit. It is presented ###to compensated for NMOS missmatch error at MOS differential type voltage averaging circuit. ###The proposed circuit consists of a voltage averaging and a SV sample/hold (S/H) circuit. It can ###operate using nonoverlapping three phase clocks. Performance of this circuit is verified by PSpice ###simulations.

  10. 46 CFR 169.670 - Circuit breakers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Circuit breakers. 169.670 Section 169.670 Shipping COAST... Gross Tons § 169.670 Circuit breakers. Each circuit breaker must be of the manually reset type designed... the circuit without damage to the circuit breaker....

  11. Photodiode circuits for retinal prostheses.

    Science.gov (United States)

    Loudin, J D; Cogan, S F; Mathieson, K; Sher, A; Palanker, D V

    2011-10-01

    Photodiode circuits show promise for the development of high-resolution retinal prostheses. While several of these systems have been constructed and some even implanted in humans, existing descriptions of the complex optoelectronic interaction between light, photodiode, and the electrode/electrolyte load are limited. This study examines this interaction in depth with theoretical calculations and experimental measurements. Actively biased photoconductive and passive photovoltaic circuits are investigated, with the photovoltaic circuits consisting of one or more diodes connected in series, and the photoconductive circuits consisting of a single diode in series with a pulsed bias voltage. Circuit behavior and charge injection levels were markedly different for platinum and sputtered iridium-oxide film (SIROF) electrodes. Photovoltaic circuits were able to deliver 0.038 mC/cm(2) (0.75 nC/phase) per photodiode with 50- μm platinum electrodes, and 0.54-mC/cm(2) (11 nC/phase) per photodiode with 50-μ m SIROF electrodes driven with 0.5-ms pulses of light at 25 Hz. The same pulses applied to photoconductive circuits with the same electrodes were able to deliver charge injections as high as 0.38 and 7.6 mC/cm(2) (7.5 and 150 nC/phase), respectively. We demonstrate photovoltaic stimulation of rabbit retina in-vitro, with 0.5-ms pulses of 905-nm light using peak irradiance of 1 mW/mm(2). Based on the experimental data, we derive electrochemical and optical safety limits for pixel density and charge injection in various circuits. While photoconductive circuits offer smaller pixels, photovoltaic systems do not require an external bias voltage. Both classes of circuits show promise for the development of high-resolution optoelectronic retinal prostheses.

  12. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat

    Science.gov (United States)

    Qiu, Yifu; Nguyen, Khoa D.; Odegaard, Justin I.; Cui, Xiaojin; Tian, Xiaoyu; Locksley, Richard M.; Palmiter, Richard D.; Chawla, Ajay

    2014-01-01

    SUMMARY Beige fat, which expresses the thermogenic protein UCP1, provides a defense against cold and obesity. Although a cold environment is the physiologic stimulus for inducing beige fat in mice and humans, the events that lead from the sensing of cold to the development of beige fat remain poorly understood. Here, we identify the efferent beige fat thermogenic circuit, consisting of eosinophils, type 2 cytokines interleukin (IL)-4/13 and alternatively activated macrophages. Genetic loss of eosinophils or IL-4/13 signaling impairs cold-induced biogenesis of beige fat. Mechanistically, macrophages recruited to cold-stressed subcutaneous white adipose tissue (scWAT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine production, factors required for browning of scWAT. Conversely, administration of IL-4 to thermoneutral mice increases beige fat mass and thermogenic capacity to ameliorate pre-established obesity. Together, our findings have uncovered the efferent circuit controlling biogenesis of beige fat and provide support for its targeting to treat obesity. PMID:24906148

  13. Material and mechanical factors:new strategy in cellular neurogenesis

    Institute of Scientific and Technical Information of China (English)

    Hillary Stoll; Il Keun Kwon; Jung Yul Lim

    2014-01-01

    Since damaged neural circuits are not generally self-recovered, developing methods to stimulate neurogenesis is critically required. Most studies have examined the effects of soluble pharma-cological factors on the cellular neurogenesis. On the other hand, it is now recognized that the other extracellular factors, including material and mechanical cues, also have a strong potential to induce cellular neurogenesis. This article will review recent data on the material (chemical patterning, micro/nano-topography, carbon nanotube, graphene) and mechanical (static cue from substrate stiffness, dynamic cue from stretch and lfow shear) stimulations of cellular neuro-genesis. These approaches may provide new neural regenerative medicine protocols. Scaffolding material templates capable of triggering cellular neurogenesis can be explored in the presence of neurogenesis-stimulatory mechanical environments, and also with conventional soluble factors, to enhance axonal growth and neural network formation in neural tissue engineering.

  14. Epigenetics and Cellular Metabolism

    Science.gov (United States)

    Xu, Wenyi; Wang, Fengzhong; Yu, Zhongsheng; Xin, Fengjiao

    2016-01-01

    Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external stimuli into transcriptional response. Emerging evidence reveals the concept that epigenetic signatures are essential for the proper maintenance of cellular metabolism. On the other hand, the metabolite, a main environmental input, can also influence the processing of epigenetic memory. Here, we summarize the recent research progress in the epigenetic regulation of cellular metabolism and discuss how the dysfunction of epigenetic machineries influences the development of metabolic disorders such as diabetes and obesity; then, we focus on discussing the notion that manipulating metabolites, the fuel of cell metabolism, can function as a strategy for interfering epigenetic machinery and its related disease progression as well. PMID:27695375

  15. Architected Cellular Materials

    Science.gov (United States)

    Schaedler, Tobias A.; Carter, William B.

    2016-07-01

    Additive manufacturing enables fabrication of materials with intricate cellular architecture, whereby progress in 3D printing techniques is increasing the possible configurations of voids and solids ad infinitum. Examples are microlattices with graded porosity and truss structures optimized for specific loading conditions. The cellular architecture determines the mechanical properties and density of these materials and can influence a wide range of other properties, e.g., acoustic, thermal, and biological properties. By combining optimized cellular architectures with high-performance metals and ceramics, several lightweight materials that exhibit strength and stiffness previously unachievable at low densities were recently demonstrated. This review introduces the field of architected materials; summarizes the most common fabrication methods, with an emphasis on additive manufacturing; and discusses recent progress in the development of architected materials. The review also discusses important applications, including lightweight structures, energy absorption, metamaterials, thermal management, and bioscaffolds.

  16. Cellular blue naevus

    Directory of Open Access Journals (Sweden)

    Mittal R

    2001-01-01

    Full Text Available A 31-year-old man had asymptomatic, stationary, 1.5X2 cm, shiny, smooth, dark blue nodule on dorsum of right hand since 12-14 years. In addition he had developed extensive eruption of yellow to orange papulonodular lesions on extensors of limbs and buttocks since one and half months. Investigations confirmed that yellow papules were xanthomatosis and he had associated diabetes mellitus and hyperlipidaemia. Biopsy of blue nodule confirmed the clinical diagnosis of cellular blue naevus. Cellular blue naevus is rare and its association with xanthomatosis and diabetes mellitus were interesting features of above patients which is being reported for its rarity.

  17. Experimental Device for Learning of Logical Circuit Design using Integrated Circuits

    OpenAIRE

    石橋, 孝昭

    2012-01-01

    This paper presents an experimental device for learning of logical circuit design using integrated circuits and breadboards. The experimental device can be made at a low cost and can be used for many subjects such as logical circuits, computer engineering, basic electricity, electrical circuits and electronic circuits. The proposed device is effective to learn the logical circuits than the usual lecture.

  18. 30 CFR 75.800 - High-voltage circuits; circuit breakers.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage circuits; circuit breakers. 75.800... § 75.800 High-voltage circuits; circuit breakers. High-voltage circuits entering the underground area of any coal mine shall be protected by suitable circuit breakers of adequate interrupting...

  19. Performance analysis of electrical circuits /PANE/

    Science.gov (United States)

    Johnson, K. L.; Steinberg, L. L.

    1968-01-01

    Automated statistical and worst case computer program has been designed to perform dc and ac steady circuit analyses. The program determines the worst case circuit performance by solving circuit equations.

  20. Variational integrators for electric circuits

    Energy Technology Data Exchange (ETDEWEB)

    Ober-Blöbaum, Sina, E-mail: sinaob@math.upb.de [Computational Dynamics and Optimal Control, University of Paderborn (Germany); Tao, Molei [Courant Institute of Mathematical Sciences, New York University (United States); Cheng, Mulin [Applied and Computational Mathematics, California Institute of Technology (United States); Owhadi, Houman; Marsden, Jerrold E. [Control and Dynamical Systems, California Institute of Technology (United States); Applied and Computational Mathematics, California Institute of Technology (United States)

    2013-06-01

    In this contribution, we develop a variational integrator for the simulation of (stochastic and multiscale) electric circuits. When considering the dynamics of an electric circuit, one is faced with three special situations: 1. The system involves external (control) forcing through external (controlled) voltage sources and resistors. 2. The system is constrained via the Kirchhoff current (KCL) and voltage laws (KVL). 3. The Lagrangian is degenerate. Based on a geometric setting, an appropriate variational formulation is presented to model the circuit from which the equations of motion are derived. A time-discrete variational formulation provides an iteration scheme for the simulation of the electric circuit. Dependent on the discretization, the intrinsic degeneracy of the system can be canceled for the discrete variational scheme. In this way, a variational integrator is constructed that gains several advantages compared to standard integration tools for circuits; in particular, a comparison to BDF methods (which are usually the method of choice for the simulation of electric circuits) shows that even for simple LCR circuits, a better energy behavior and frequency spectrum preservation can be observed using the developed variational integrator.

  1. Cellular rehabilitation of photobiomodulation

    Science.gov (United States)

    Liu, Timon Cheng-Yi; Yuan, Jian-Qin; Wang, Yan-Fang; Xu, Xiao-Yang; Liu, Song-Hao

    2007-05-01

    Homeostasis is a term that refers to constancy in a system. A cell in homeostasis normally functions. There are two kinds of processes in the internal environment and external environment of a cell, the pathogenic processes (PP) which disrupts the old homeostasis (OH), and the sanogenetic processes (SP) which restores OH or establishes a new homeostasis (NH). Photobiomodualtion (PBM), the cell-specific effects of low intensity monochromatic light or low intensity laser irradiation (LIL) on biological systems, is a kind of modulation on PP or SP so that there is no PBM on a cell in homeostasis. There are two kinds of pathways mediating PBM, the membrane endogenetic chromophores mediating pathways which often act through reactive oxygen species, and membrane proteins mediating pathways which often enhance cellular SP so that it might be called cellular rehabilitation. The cellular rehabilitation of PBM will be discussed in this paper. It is concluded that PBM might modulate the disruption of cellular homeostasis induced by pathogenic factors such as toxin until OH has been restored or NH has been established, but can not change homeostatic processes from one to another one.

  2. Cellular Response to Irradiation

    Institute of Scientific and Technical Information of China (English)

    LIU Bo; YAN Shi-Wei

    2011-01-01

    To explore the nonlinear activities of the cellular signaling system composed of one transcriptional arm and one protein-interaction arm, we use an irradiation-response module to study the dynamics of stochastic interactions.It is shown that the oscillatory behavior could be described in a unified way when the radiation-derived signal and noise are incorporated.

  3. The cellular energy crisis: mitochondria and cell death.

    Science.gov (United States)

    Waterhouse, Nigel J

    2003-01-01

    Exploding nuclear reactors, environmental destruction, and global warming; the danger of energy production is clear. It is quite remarkable that in this modern age, where power usage is at a premium, we find that even on a cellular level, generation of large quantities of power comes at a cost. Mitochondria, which produce the majority of cellular energy in the form of ATP, have recently been shown to play an essential role in the death of a cell by a process known as apoptosis. During apoptosis, the integrity of mitochondria is compromised and various pro-apoptotic proteins are released into the cytoplasm. This results in activation of caspases, proteases that orchestrate the death of the cell. Cells in which apoptosis is inhibited upstream of mitochondria generally maintain the potential to proliferate, whereas inhibition of caspases downstream of mitochondria generally only delays cell death. Although breaches of the mitochondrial outer membrane result in the release of proteins that are important for respiration, mitochondria appear capable of maintaining at least some of their functions, including ATP production, even after this event. This has important implications both for the mechanism of outer-membrane permeabilization and the mechanism by which the cells eventually die in the absence of caspase activity. The events surrounding the breach of the mitochondrial outer membrane during apoptosis have therefore received much interest over the past few years.

  4. A dynamic cellular vertex model of growing epithelial tissues

    Science.gov (United States)

    Lin, Shao-Zhen; Li, Bo; Feng, Xi-Qiao

    2017-03-01

    Intercellular interactions play a significant role in a wide range of biological functions and processes at both the cellular and tissue scales, for example, embryogenesis, organogenesis, and cancer invasion. In this paper, a dynamic cellular vertex model is presented to study the morphomechanics of a growing epithelial monolayer. The regulating role of stresses in soft tissue growth is revealed. It is found that the cells originating from the same parent cell in the monolayer can orchestrate into clustering patterns as the tissue grows. Collective cell migration exhibits a feature of spatial correlation across multiple cells. Dynamic intercellular interactions can engender a variety of distinct tissue behaviors in a social context. Uniform cell proliferation may render high and heterogeneous residual compressive stresses, while stress-regulated proliferation can effectively release the stresses, reducing the stress heterogeneity in the tissue. The results highlight the critical role of mechanical factors in the growth and morphogenesis of epithelial tissues and help understand the development and invasion of epithelial tumors.

  5. Supporting Discourse and Classroom Orchestration in a Knowledge Community and Inquiry Approach

    Science.gov (United States)

    Fong, Cresencia G. W.

    activity sequence. In each successive iteration, exciting technology features of CK were refined in response to critical evaluations of the previous enactment. New features were also added, including new tagging and data mining, which served to extend new forms of activity sequences. Initial iterations included simple applications as a supplemental brainstorming environment, where the final iteration employed CK to coordinate a structured progression from brainstorming through inquiry proposals and then open inquiry investigations. Findings include the identification of a basic Reflect-Refocus-Release orchestration pattern, in which the teacher helps students to apprehend the progress or gaps in their inquiry, using content or patterns within the CK notes, engaging them in productive discussions, then releasing them to respond to the discussion appropriately. Additionally, four discourse orientations were observed within the Reflection phase of the pattern: (1) teacher reflection, (2) community (whole-class) reflection, (3) individual (student) reflections, (4) community (whole class) instruction. Within these orientations, teachers employed various discourse functions that served purposes of revoicing student ideas, norming the positions across the community, and casting students in various inquiry roles. The two teachers varied in how they employed these orientations, and also changed their patterns from one iteration to the next, reflecting the shifting task demands for discourse from one iteration to the next.

  6. Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane.

    Science.gov (United States)

    Vitriol, Eric A; Zheng, James Q

    2012-03-22

    Growth cones, found at the tip of axonal projections, are the sensory and motile organelles of developing neurons that enable axon pathfinding and target recognition for precise wiring of the neural circuitry. To date, many families of conserved guidance molecules and their corresponding receptors have been identified that work in space and time to ensure billions of axons to reach their targets. Research in the past two decades has also gained significant insight into the ways in which growth cones translate extracellular signals into directional migration. This review aims to examine new progress toward understanding the cellular mechanisms underlying directional motility of the growth cone and to discuss questions that remain to be addressed. Specifically, we will focus on the cellular ensemble of cytoskeleton, adhesion, and membrane and examine how the intricate interplay between these processes orchestrates the directed movement of growth cones.

  7. Determining Covers in Combinational Circuits

    Directory of Open Access Journals (Sweden)

    Ljubomir Cvetkovic

    2011-05-01

    Full Text Available In this paper we propose a procedure for determining 0- or 1-cover of an arbitrary line in a combinational circuit. When determining a cover we do not need Boolean expression for the line; only the circuit structure is used. Within the proposed procedure we use the tools of the cube theory, in particular, some operations defined on cubes. The procedure can be applied for determining 0- and 1- covers of output lines in programmable logic devices. Basically, this procedure is a method for the analysis of a combinational circuit.

  8. Overpulse railgun energy recovery circuit

    Energy Technology Data Exchange (ETDEWEB)

    Honig, E.M.

    1984-09-28

    The invention presented relates to a high-power pulsing circuit and more particularly to a repetitive pulse inductive energy storage and transfer circuit for an electromagnetic launcher. In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, an overpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  9. Counterpulse railgun energy recovery circuit

    Energy Technology Data Exchange (ETDEWEB)

    Honig, E.M.

    1984-09-28

    The invention presented relates to a high-power pulsing circuit and more particularly to a repetitive pulse inductive energy storage and transfer circuit for an electromagnetic launcher. In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, a counterpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  10. Secure integrated circuits and systems

    CERN Document Server

    Verbauwhede, Ingrid MR

    2010-01-01

    On any advanced integrated circuit or 'system-on-chip' there is a need for security. In many applications the actual implementation has become the weakest link in security rather than the algorithms or protocols. The purpose of the book is to give the integrated circuits and systems designer an insight into the basics of security and cryptography from the implementation point of view. As a designer of integrated circuits and systems it is important to know both the state-of-the-art attacks as well as the countermeasures. Optimizing for security is different from optimizations for speed, area,

  11. The Maplin electronic circuits handbook

    CERN Document Server

    Tooley, Michael

    2015-01-01

    The Maplin Electronic Circuits Handbook provides pertinent data, formula, explanation, practical guidance, theory and practical guidance in the design, testing, and construction of electronic circuits. This book discusses the developments in electronics technology techniques.Organized into 11 chapters, this book begins with an overview of the common types of passive component. This text then provides the reader with sufficient information to make a correct selection of passive components for use in the circuits. Other chapters consider the various types of the most commonly used semiconductor

  12. Finite Field Arithmetic Architecture Based on Cellular Array

    Directory of Open Access Journals (Sweden)

    Kee-Won Kim

    2015-05-01

    Full Text Available Recently, various finite field arithmetic structures are introduced for VLSI circuit implementation on cryptosystems and error correcting codes. In this study, we present an efficient finite field arithmetic architecture based on cellular semi-systolic array for Montgomery multiplication by choosing a proper Montgomery factor which is highly suitable for the design on parallel structures. Therefore, our architecture has reduced a time complexity by 50% compared to typical architecture.

  13. A Novel Design of Half Subtractor using Reversible Feynman Gate in Quantum Dot cellular Automata

    Directory of Open Access Journals (Sweden)

    Rubina Akter

    2014-12-01

    Full Text Available Quantum Dot cellular Automata (QCA is an emerging, promising alternative to CMOS technology that performs its task by encoding binary information on electronic charge configuration of a cell. All circuit based on QCA has an advantages of high speed, high parallel processing, high integrityand low power consumption. Reversible logic gates are the leading part in Quantum Dot cellular Automata. Reversible logic gates have an extensive feature that does not lose information. In this paper, we present a novel architecture of half subtractor gate design by reversible Feynman gate. This circuit is designedbased on QCA logic gates such as QCA majority voter gate, majority AND gate, majority OR gate and inverter gate. This circuit will provide an effective working efficiency on computational units of the digital circuit system.

  14. Chaos Control for Chua's Circuits

    Science.gov (United States)

    Tôrres, L. A. B.; Aguirre, L. A.; Palhares, R. M.; Mendes, E. M. A. M.

    The practical implementation of Chua's circuit control methods is discussed in this chapter. In order to better address this subject, an inductorless Chua's circuit realization is first presented, followed by practical issues related to data analysis, mathematical modelling, and dynamical characterization associated to this electronic chaotic oscillator. As a consequence of the investigation of different control strategies applied to Chua's circuit, a tradeoff among control objective, control energy, and model complexity is devised, which quite naturally leads to a principle that seems to be of general nature: the Information Transmission Via Control (ITVC) for nonlinear oscillators. The main purpose of the present chapter is to serve as an introductory guide to the universe of Chua's circuit control, synchronization, and mathematical modelling.

  15. CADAT integrated circuit mask analysis

    Science.gov (United States)

    1981-01-01

    CADAT System Mask Analysis Program (MAPS2) is automated software tool for analyzing integrated-circuit mask design. Included in MAPS2 functions are artwork verification, device identification, nodal analysis, capacitance calculation, and logic equation generation.

  16. Circuit design on plastic foils

    CERN Document Server

    Raiteri, Daniele; Roermund, Arthur H M

    2015-01-01

    This book illustrates a variety of circuit designs on plastic foils and provides all the information needed to undertake successful designs in large-area electronics.  The authors demonstrate architectural, circuit, layout, and device solutions and explain the reasons and the creative process behind each. Readers will learn how to keep under control large-area technologies and achieve robust, reliable circuit designs that can face the challenges imposed by low-cost low-temperature high-throughput manufacturing.   • Discusses implications of problems associated with large-area electronics and compares them to standard silicon; • Provides the basis for understanding physics and modeling of disordered material; • Includes guidelines to quickly setup the basic CAD tools enabling efficient and reliable designs; • Illustrates practical solutions to cope with hard/soft faults, variability, mismatch, aging and bias stress at architecture, circuit, layout, and device levels.

  17. Wireless communications circuits and systems

    CERN Document Server

    Sun, Yichuang

    2004-01-01

    This new book examines integrated circuits, systems and transceivers for wireless and mobile communications. It covers the most recent developments in key RF, IF, analogue, mixed-signal components and single-chip transceivers in CMOS technology.

  18. Optimizing Transmission Line Matching Circuits

    OpenAIRE

    Novak, S.

    1996-01-01

    When designing transmission line matching circuits, there exist often overlooked, additional, not much used, degree of choice in the selection of the transmission line impedance. In this work are presented results of CAD analysis for the two element transmission line matching networks, demonstrating that selecting matching circuits transmission lines with higher impedance, than usually used 50 or 75 ohms, can in most cases substantially decrease the physical dimension of the final matching ci...

  19. Spinal sensory circuits in motion

    OpenAIRE

    2016-01-01

    International audience; The role of sensory feedback in shaping locomotion has been long debated. Recent advances in genetics and behavior analysis revealed the importance of proprioceptive pathways in spinal circuits. The mechanisms underlying peripheral mechanosensation enabled to unravel the networks that feedback to spinal circuits in order to modulate locomotion. Sensory inputs to the vertebrate spinal cord were long thought to originate from the periphery. Recent studies challenge this ...

  20. Neural Circuits on a Chip

    Directory of Open Access Journals (Sweden)

    Md. Fayad Hasan

    2016-09-01

    Full Text Available Neural circuits are responsible for the brain’s ability to process and store information. Reductionist approaches to understanding the brain include isolation of individual neurons for detailed characterization. When maintained in vitro for several days or weeks, dissociated neurons self-assemble into randomly connected networks that produce synchronized activity and are capable of learning. This review focuses on efforts to control neuronal connectivity in vitro and construct living neural circuits of increasing complexity and precision. Microfabrication-based methods have been developed to guide network self-assembly, accomplishing control over in vitro circuit size and connectivity. The ability to control neural connectivity and synchronized activity led to the implementation of logic functions using living neurons. Techniques to construct and control three-dimensional circuits have also been established. Advances in multiple electrode arrays as well as genetically encoded, optical activity sensors and transducers enabled highly specific interfaces to circuits composed of thousands of neurons. Further advances in on-chip neural circuits may lead to better understanding of the brain.

  1. Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Sayantan, E-mail: sayantan_bose@hms.harvard.edu [Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208-3500 (United States); Jardetzky, Theodore S. [Department of Structural Biology and Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305 (United States); Lamb, Robert A., E-mail: ralamb@northwestern.edu [Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208-3500 (United States); Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208-3500 (United States)

    2015-05-15

    The Paramyxoviridae include some of the great and ubiquitous disease-causing viruses of humans and animals. In most paramyxoviruses, two viral membrane glycoproteins, fusion protein (F) and receptor binding protein (HN, H or G) mediate a concerted process of recognition of host cell surface molecules followed by fusion of viral and cellular membranes, resulting in viral nucleocapsid entry into the cytoplasm. The interactions between the F and HN, H or G viral glycoproteins and host molecules are critical in determining host range, virulence and spread of these viruses. Recently, atomic structures, together with biochemical and biophysical studies, have provided major insights into how these two viral glycoproteins successfully interact with host receptors on cellular membranes and initiate the membrane fusion process to gain entry into cells. These studies highlight the conserved core mechanisms of paramyxovirus entry that provide the fundamental basis for rational anti-viral drug design and vaccine development. - Highlights: • New structural and functional insights into paramyxovirus entry mechanisms. • Current data on paramyxovirus glycoproteins suggest a core conserved entry mechanism. • Diverse mechanisms preventing premature fusion activation exist in these viruses. • Precise spacio-temporal interplay between paramyxovirus glycoproteins initiate entry.

  2. Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

    Science.gov (United States)

    Sengerová, Blanka; Wang, Anderson T; McHugh, Peter J

    2011-12-01

    DNA interstrand cross-links (ICLs) pose a significant threat to genomic and cellular integrity by blocking essential cellular processes, including replication and transcription. In mammalian cells, much ICL repair occurs in association with DNA replication during S phase, following the stalling of a replication fork at the block caused by an ICL lesion. Here, we review recent work showing that the XPF-ERCC1 endonuclease and the hSNM1A exonuclease act in the same pathway, together with SLX4, to initiate ICL repair, with the MUS81-EME1 fork incision activity becoming important in the absence of the XPF-SNM1A-SLX4-dependent pathway. Another nuclease, the Fanconi anemia-associated nuclease (FAN1), has recently been implicated in the repair of ICLs, and we discuss the possible ways in which the activities of different nucleases at the ICL-stalled replication fork may be coordinated. In relation to this, we briefly speculate on the possible role of SLX4, which contains XPF and MUS81- interacting domains, in the coordination of ICL repair nucleases.

  3. Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy consuming redox circuit

    OpenAIRE

    2015-01-01

    Cellular proteins rely on reversible redox reactions to establish and maintain biological structure and function. How redox catabolic (NAD+:NADH) and anabolic (NADP+:NADPH) processes integrate during metabolism to maintain cellular redox homeostasis however is unknown. The present work identifies a continuously cycling, mitochondrial membrane potential-dependent redox circuit between the pyruvate dehydrogenase complex (PDHC) and nicotinamide nucleotide transhydrogenase (NNT). PDHC is shown to...

  4. Molecular and Cellular Signaling

    CERN Document Server

    Beckerman, Martin

    2005-01-01

    A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases ...

  5. Environment Aware Cellular Networks

    KAUST Repository

    Ghazzai, Hakim

    2015-02-01

    The unprecedented rise of mobile user demand over the years have led to an enormous growth of the energy consumption of wireless networks as well as the greenhouse gas emissions which are estimated currently to be around 70 million tons per year. This significant growth of energy consumption impels network companies to pay huge bills which represent around half of their operating expenditures. Therefore, many service providers, including mobile operators, are looking for new and modern green solutions to help reduce their expenses as well as the level of their CO2 emissions. Base stations are the most power greedy element in cellular networks: they drain around 80% of the total network energy consumption even during low traffic periods. Thus, there is a growing need to develop more energy-efficient techniques to enhance the green performance of future 4G/5G cellular networks. Due to the problem of traffic load fluctuations in cellular networks during different periods of the day and between different areas (shopping or business districts and residential areas), the base station sleeping strategy has been one of the main popular research topics in green communications. In this presentation, we present several practical green techniques that provide significant gains for mobile operators. Indeed, combined with the base station sleeping strategy, these techniques achieve not only a minimization of the fossil fuel consumption but also an enhancement of mobile operator profits. We start with an optimized cell planning method that considers varying spatial and temporal user densities. We then use the optimal transport theory in order to define the cell boundaries such that the network total transmit power is reduced. Afterwards, we exploit the features of the modern electrical grid, the smart grid, as a new tool of power management for cellular networks and we optimize the energy procurement from multiple energy retailers characterized by different prices and pollutant

  6. Multi-Layer E-Textile Circuits

    Science.gov (United States)

    Dunne, Lucy E.; Bibeau, Kaila; Mulligan, Lucie; Frith, Ashton; Simon, Cory

    2012-01-01

    Stitched e-textile circuits facilitate wearable, flexible, comfortable wearable technology. However, while stitched methods of e-textile circuits are common, multi-layer circuit creation remains a challenge. Here, we present methods of stitched multi-layer circuit creation using accessible tools and techniques.

  7. 30 CFR 56.6403 - Branch circuits.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Branch circuits. 56.6403 Section 56.6403... Blasting § 56.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate the circuits to be used....

  8. Equivalence Checking of Hierarchical Combinational Circuits

    DEFF Research Database (Denmark)

    Williams, Poul Frederick; Hulgaard, Henrik; Andersen, Henrik Reif

    1999-01-01

    This paper presents a method for verifying that two hierarchical combinational circuits implement the same Boolean functions. The key new feature of the method is its ability to exploit the modularity of circuits to reuse results obtained from one part of the circuits in other parts. We demonstra...... our method on large adder and multiplier circuits....

  9. Difference-Equation/Flow-Graph Circuit Analysis

    Science.gov (United States)

    Mcvey, I. M.

    1988-01-01

    Numerical technique enables rapid, approximate analyses of electronic circuits containing linear and nonlinear elements. Practiced in variety of computer languages on large and small computers; for circuits simple enough, programmable hand calculators used. Although some combinations of circuit elements make numerical solutions diverge, enables quick identification of divergence and correction of circuit models to make solutions converge.

  10. Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control

    Directory of Open Access Journals (Sweden)

    Massimo Trusel

    2015-11-01

    Full Text Available The basal ganglia play a critical role in shaping motor behavior. For this function, the activity of medium spiny neurons (MSNs of the striatonigral and striatopallidal pathways must be integrated. It remains unclear whether the activity of the two pathways is primarily coordinated by synaptic plasticity mechanisms. Using a model of Parkinson’s disease, we determined the circuit and behavioral effects of concurrently regulating cell-type-specific forms of corticostriatal long-term synaptic depression (LTD by inhibiting small-conductance Ca2+-activated K+ channels (SKs of the dorsolateral striatum. At striatopallidal synapses, SK channel inhibition rescued the disease-linked deficits in endocannabinoid (eCB-dependent LTD. At striatonigral cells, inhibition of these channels counteracted a form of adenosine-mediated LTD by activating the ERK cascade. Interfering with eCB-, adenosine-, and ERK signaling in vivo alleviated motor abnormalities, which supports that synaptic modulation of striatal pathways affects behavior. Thus, our results establish a central role of coordinated synaptic plasticity at MSN subpopulations in motor control.

  11. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.

    Directory of Open Access Journals (Sweden)

    Diana Andrea Fernandes de Abreu

    2014-03-01

    Full Text Available Insulin-like peptides (ILPs play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses. Our systematic studies identify an ILP-based combinatorial code for these phenotypes characterized by substantial functional specificity and diversity rather than global redundancy. Notably, we show that ILPs regulate each other transcriptionally, uncovering an ILP-to-ILP regulatory network that underlies the combinatorial phenotypic coding by the ILP family. Extensive analyses of genetic interactions among ILPs reveal how their signals are integrated. A combined analysis of these functional and regulatory ILP interactions identifies local genetic circuits that act in parallel and interact by crosstalk, feedback and compensation. This organization provides emergent mechanisms for phenotypic specificity and graded regulation for the combinatorial phenotypic coding we observe. Our findings also provide insights into how large hormonal networks regulate diverse traits.

  12. dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.

    Science.gov (United States)

    Manitt, C; Eng, C; Pokinko, M; Ryan, R T; Torres-Berrío, A; Lopez, J P; Yogendran, S V; Daubaras, M J J; Grant, A; Schmidt, E R E; Tronche, F; Krimpenfort, P; Cooper, H M; Pasterkamp, R J; Kolb, B; Turecki, G; Wong, T P; Nestler, E J; Giros, B; Flores, C

    2013-12-17

    Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC dopamine (DA) projections reach maturity only in early adulthood, when their control over cognition becomes fully functional. The mechanisms governing this protracted and unique development are unknown. Here we identify dcc as the first DA neuron gene to regulate mPFC connectivity during adolescence and dissect the mechanisms involved. Reduction or loss of dcc from DA neurons by Cre-lox recombination increased mPFC DA innervation. Underlying this was the presence of ectopic DA fibers that normally innervate non-cortical targets. Altered DA input changed the anatomy and electrophysiology of mPFC circuits, leading to enhanced cognitive flexibility. All phenotypes only emerged in adulthood. Using viral Cre, we demonstrated that dcc organizes mPFC wiring specifically during adolescence. Variations in DCC may determine differential predisposition to mPFC disorders in humans. Indeed, DCC expression is elevated in brains of antidepressant-free subjects who committed suicide.

  13. Comparison between four piezoelectric energy harvesting circuits

    Institute of Scientific and Technical Information of China (English)

    Jinhao QIU; Hao JIANG; Hongli JI; Kongjun ZHU

    2009-01-01

    This paper investigates and compares the efficiencies of four different interfaces for vibration-based energy harvesting systems. Among those four circuits, two circuits adopt the synchronous switching technique, in which the circuit is switched synchronously with the vibration. In this study, a simple source-less trigger circuit used to control the synchronized switch is proposed and two interface circuits of energy harvesting systems are designed based on the trigger circuit. To validate the effectiveness of the proposed circuits, an experimental system was established and the power harvested by those circuits from a vibration beam was measured. Experimental results show that the two new circuits can increase the harvested power by factors 2.6 and 7, respectively, without consuming extra power in the circuits.

  14. Using Combinational Circuits for Control Purposes

    Directory of Open Access Journals (Sweden)

    Maher A. Nabulsi

    2009-01-01

    Full Text Available Problem statement: Combinational circuits are used in computers for generating binary control decisions and for providing digital components for data processing. Approach: The use of combinational circuits and logic gates to control other circuits was discussed. Different systems that use logic gates, multiplexers, decoders and encoders to control different circuits were presented. This study presented a design and implementation of some combinational circuits such as a decoder, an encoder, a multiplexer, a bus system and read/write memory operations. Results: When we connected some types of combinational circuits to the inputs/outputs of digital circuit, these combinational circuits can help us to manage and flow a different types of control signals through a large digital circuit. Conclusion: Many combinational circuits had a good function which can be used for controlling different parts of any digital system and they produce a suitable way to transfer a control signals between different digital components of any large digital system.

  15. Stripline/Microstrip Transition in Multilayer Circuit Board

    Science.gov (United States)

    Epp, Larry; Khan, Abdur

    2005-01-01

    A stripline-to-microstrip transition has been incorporated into a multilayer circuit board that supports a distributed solid-state microwave power amplifier, for the purpose of coupling the microwave signal from a buried-layer stripline to a top-layer microstrip. The design of the transition could be adapted to multilayer circuit boards in such products as cellular telephones (for connecting between circuit-board signal lines and antennas), transmitters for Earth/satellite communication systems, and computer mother boards (if processor speeds increase into the range of tens of gigahertz). The transition is designed to satisfy the following requirements in addition to the basic coupling requirement described above: (1) The transition must traverse multiple layers, including intermediate layers that contain DC circuitry. (2) The transition must work at a frequency of 32 GHz with low loss and low reflection. (3) The power delivered by the transition to top-layer microstrip must be split equally in opposite directions along the microstrip. Referring to the figure, this amounts to a requirement that when power is supplied to input port 1, equal amounts of power flow through output ports 2 and 3. (4) The signal-line via that is necessarily a part of such a transition must not be what is known in the art as a blind via; that is, it must span the entire thickness of the circuit board.

  16. Progress in understanding mood disorders: optogenetic dissection of neural circuits.

    Science.gov (United States)

    Lammel, S; Tye, K M; Warden, M R

    2014-01-01

    Major depression is characterized by a cluster of symptoms that includes hopelessness, low mood, feelings of worthlessness and inability to experience pleasure. The lifetime prevalence of major depression approaches 20%, yet current treatments are often inadequate both because of associated side effects and because they are ineffective for many people. In basic research, animal models are often used to study depression. Typically, experimental animals are exposed to acute or chronic stress to generate a variety of depression-like symptoms. Despite its clinical importance, very little is known about the cellular and neural circuits that mediate these symptoms. Recent advances in circuit-targeted approaches have provided new opportunities to study the neuropathology of mood disorders such as depression and anxiety. We review recent progress and highlight some studies that have begun tracing a functional neuronal circuit diagram that may prove essential in establishing novel treatment strategies in mood disorders. First, we shed light on the complexity of mesocorticolimbic dopamine (DA) responses to stress by discussing two recent studies reporting that optogenetic activation of midbrain DA neurons can induce or reverse depression-related behaviors. Second, we describe the role of the lateral habenula circuitry in the pathophysiology of depression. Finally, we discuss how the prefrontal cortex controls limbic and neuromodulatory circuits in mood disorders.

  17. The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

    DEFF Research Database (Denmark)

    Meerang, Mayura; Ritz, Danilo; Paliwal, Shreya;

    2011-01-01

    Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling...... complexes and efficient DSB repair after exposure to ionizing radiation. p97 is recruited to DNA lesions by its ubiquitin adaptor UFD1-NPL4 and Lys-48-linked ubiquitin (K48-Ub) chains, whose formation is regulated by RNF8. p97 subsequently removes K48-Ub conjugates from sites of DNA damage to orchestrate...... proper association of 53BP1, BRCA1 and RAD51, three factors critical for DNA repair and genome surveillance mechanisms. Impairment of p97 activity decreases the level of DSB repair and cell survival after exposure to ionizing radiation. These findings identify the p97-UFD1-NPL4 complex as an essential...

  18. Cellular reprogramming through mitogen-activated protein kinases

    Directory of Open Access Journals (Sweden)

    Justin eLee

    2015-10-01

    Full Text Available Mitogen-activated protein kinase (MAPK cascades are conserved eukaryote signaling modules where MAPKs, as the final kinases in the cascade, phosphorylate protein substrates to regulate cellular processes. While some progress in the identification of MAPK substrates has been made in plants, the knowledge on the spectrum of substrates and their mechanistic action is still fragmentary. In this focused review, we discuss the biological implications of the data in our original paper (Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana; Frontiers in Plant Science 5: 554 in the context of related research. In our work, we mimicked in vivo activation of two stress-activated MAPKs, MPK3 and MPK6, through transgenic manipulation of Arabidopsis thaliana and used phosphoproteomics analysis to identify potential novel MAPK substrates. Here, we plotted the identified putative MAPK substrates (and downstream phosphoproteins as a global protein clustering network. Based on a highly stringent selection confidence level, the core networks highlighted a MAPK-induced cellular reprogramming at multiple levels of gene and protein expression – including transcriptional, post-transcriptional, translational, post-translational (such as protein modification, folding and degradation steps, and also protein re-compartmentalization. Additionally, the increase in putative substrates/phosphoproteins of energy metabolism and various secondary metabolite biosynthesis pathways coincides with the observed accumulation of defense antimicrobial substances as detected by metabolome analysis. Furthermore, detection of protein networks in phospholipid or redox elements suggests activation of downstream signaling events. Taken in context with other studies, MAPKs are key regulators that reprogram cellular events to orchestrate defense signaling in eukaryotes.

  19. Instrumentation and test gear circuits manual

    CERN Document Server

    Marston, R M

    2013-01-01

    Instrumentation and Test Gear Circuits Manual provides diagrams, graphs, tables, and discussions of several types of practical circuits. The practical circuits covered in this book include attenuators, bridges, scope trace doublers, timebases, and digital frequency meters. Chapter 1 discusses the basic instrumentation and test gear principles. Chapter 2 deals with the design of passive attenuators, and Chapter 3 with passive and active filter circuits. The subsequent chapters tackle 'bridge' circuits, analogue and digital metering techniques and circuitry, signal and waveform generation, and p

  20. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  1. 30 CFR 77.506 - Electric equipment and circuits; overload and short-circuit protection.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric equipment and circuits; overload and short-circuit protection. 77.506 Section 77.506 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... circuits; overload and short-circuit protection. Automatic circuit-breaking devices or fuses of the...

  2. 30 CFR 77.800 - High-voltage circuits; circuit breakers.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage circuits; circuit breakers. 77.800... COAL MINES Surface High-Voltage Distribution § 77.800 High-voltage circuits; circuit breakers. High-voltage circuits supplying power to portable or mobile equipment shall be protected by suitable...

  3. 30 CFR 75.601-1 - Short circuit protection; ratings and settings of circuit breakers.

    Science.gov (United States)

    2010-07-01

    ... of circuit breakers. 75.601-1 Section 75.601-1 Mineral Resources MINE SAFETY AND HEALTH... Trailing Cables § 75.601-1 Short circuit protection; ratings and settings of circuit breakers. Circuit breakers providing short circuit protection for trailing cables shall be set so as not to exceed...

  4. Introduction to lethal circuit transformations

    Science.gov (United States)

    Fišer, Petr; Schmidt, Jan

    2015-12-01

    Logic optimization is a process that takes a logic circuit description (Boolean network) as an input and tries to refine it, to reduce its size and/or depth. An ideal optimization process should be able to devise an optimum implementation of a network in a reasonable time, given any circuit structure at the input. However, there are cases where it completely fails to produce even near-optimum solutions. Such cases are typically induced by non-standard circuit structure modifications. Surprisingly enough, such deviated structures are frequently present in standard benchmark sets too. We may only wonder whether it is an intention of the benchmarks creators, or just an unlucky coincidence. Even though synthesis tools should be primarily well suited for practical circuits, there is no guarantee that, e.g., a higher-level synthesis process will not generate such unlucky structures. Here we present examples of circuit transformations that lead to failure of most of state-of-the-art logic synthesis and optimization processes, both academic and commercial, and suggest actions to mitigate the disturbing effects.

  5. Logic circuits from zero forcing.

    Science.gov (United States)

    Burgarth, Daniel; Giovannetti, Vittorio; Hogben, Leslie; Severini, Simone; Young, Michael

    We design logic circuits based on the notion of zero forcing on graphs; each gate of the circuits is a gadget in which zero forcing is performed. We show that such circuits can evaluate every monotone Boolean function. By using two vertices to encode each logical bit, we obtain universal computation. We also highlight a phenomenon of "back forcing" as a property of each function. Such a phenomenon occurs in a circuit when the input of gates which have been already used at a given time step is further modified by a computation actually performed at a later stage. Finally, we show that zero forcing can be also used to implement reversible computation. The model introduced here provides a potentially new tool in the analysis of Boolean functions, with particular attention to monotonicity. Moreover, in the light of applications of zero forcing in quantum mechanics, the link with Boolean functions may suggest a new directions in quantum control theory and in the study of engineered quantum spin systems. It is an open technical problem to verify whether there is a link between zero forcing and computation with contact circuits.

  6. Dynamical compensation in physiological circuits.

    Science.gov (United States)

    Karin, Omer; Swisa, Avital; Glaser, Benjamin; Dor, Yuval; Alon, Uri

    2016-11-08

    Biological systems can maintain constant steady-state output despite variation in biochemical parameters, a property known as exact adaptation. Exact adaptation is achieved using integral feedback, an engineering strategy that ensures that the output of a system robustly tracks its desired value. However, it is unclear how physiological circuits also keep their output dynamics precise-including the amplitude and response time to a changing input. Such robustness is crucial for endocrine and neuronal homeostatic circuits because they need to provide a precise dynamic response in the face of wide variation in the physiological parameters of their target tissues; how such circuits compensate their dynamics for unavoidable natural fluctuations in parameters is unknown. Here, we present a design principle that provides the desired robustness, which we call dynamical compensation (DC). We present a class of circuits that show DC by means of a nonlinear feedback loop in which the regulated variable controls the functional mass of the controlling endocrine or neuronal tissue. This mechanism applies to the control of blood glucose by insulin and explains several experimental observations on insulin resistance. We provide evidence that this mechanism may also explain compensation and organ size control in other physiological circuits.

  7. Cellular communication through light.

    Directory of Open Access Journals (Sweden)

    Daniel Fels

    Full Text Available Information transfer is a fundamental of life. A few studies have reported that cells use photons (from an endogenous source as information carriers. This study finds that cells can have an influence on other cells even when separated with a glass barrier, thereby disabling molecule diffusion through the cell-containing medium. As there is still very little known about the potential of photons for intercellular communication this study is designed to test for non-molecule-based triggering of two fundamental properties of life: cell division and energy uptake. The study was performed with a cellular organism, the ciliate Paramecium caudatum. Mutual exposure of cell populations occurred under conditions of darkness and separation with cuvettes (vials allowing photon but not molecule transfer. The cell populations were separated either with glass allowing photon transmission from 340 nm to longer waves, or quartz being transmittable from 150 nm, i.e. from UV-light to longer waves. Even through glass, the cells affected cell division and energy uptake in neighboring cell populations. Depending on the cuvette material and the number of cells involved, these effects were positive or negative. Also, while paired populations with lower growth rates grew uncorrelated, growth of the better growing populations was correlated. As there were significant differences when separating the populations with glass or quartz, it is suggested that the cell populations use two (or more frequencies for cellular information transfer, which influences at least energy uptake, cell division rate and growth correlation. Altogether the study strongly supports a cellular communication system, which is different from a molecule-receptor-based system and hints that photon-triggering is a fine tuning principle in cell chemistry.

  8. Cellular automata: structures

    OpenAIRE

    Ollinger, Nicolas

    2002-01-01

    Jury : François Blanchard (Rapporteur), Marianne Delorme (Directeur), Jarkko Kari (Président), Jacques Mazoyer (Directeur), Dominique Perrin, Géraud Sénizergues (Rapporteur); Cellular automata provide a uniform framework to study an important problem of "complex systems" theory: how and why do system with a easily understandable -- local -- microscopic behavior can generate a more complicated -- global -- macroscopic behavior? Since its introduction in the 40s, a lot of work has been done to ...

  9. Engineering Cellular Metabolism

    DEFF Research Database (Denmark)

    Nielsen, Jens; Keasling, Jay

    2016-01-01

    Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds...... of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation....

  10. Failover in cellular automata

    CERN Document Server

    Kumar, Shailesh

    2010-01-01

    A cellular automata (CA) configuration is constructed that exhibits emergent failover. The configuration is based on standard Game of Life rules. Gliders and glider-guns form the core messaging structure in the configuration. The blinker is represented as the basic computational unit, and it is shown how it can be recreated in case of a failure. Stateless failover using primary-backup mechanism is demonstrated. The details of the CA components used in the configuration and its working are described, and a simulation of the complete configuration is also presented.

  11. Theory-Led Design of Instruments and Representations in Learning Analytics: Developing a Novel Tool for Orchestration of Online Collaborative Learning

    Science.gov (United States)

    Kelly, Nick; Thompson, Kate; Yeoman, Pippa

    2015-01-01

    This paper describes theory-led design as a way of developing novel tools for learning analytics (LA). It focuses upon the domain of automated discourse analysis (ADA) of group learning activities to help an instructor to orchestrate online groups in real-time. The paper outlines the literature on the development of LA tools within the domain of…

  12. First field demonstration of cloud datacenter workflow automation employing dynamic optical transport network resources under OpenStack and OpenFlow orchestration.

    Science.gov (United States)

    Szyrkowiec, Thomas; Autenrieth, Achim; Gunning, Paul; Wright, Paul; Lord, Andrew; Elbers, Jörg-Peter; Lumb, Alan

    2014-02-10

    For the first time, we demonstrate the orchestration of elastic datacenter and inter-datacenter transport network resources using a combination of OpenStack and OpenFlow. Programmatic control allows a datacenter operator to dynamically request optical lightpaths from a transport network operator to accommodate rapid changes of inter-datacenter workflows.

  13. Nuclear sensor signal processing circuit

    Science.gov (United States)

    Kallenbach, Gene A.; Noda, Frank T.; Mitchell, Dean J.; Etzkin, Joshua L.

    2007-02-20

    An apparatus and method are disclosed for a compact and temperature-insensitive nuclear sensor that can be calibrated with a non-hazardous radioactive sample. The nuclear sensor includes a gamma ray sensor that generates tail pulses from radioactive samples. An analog conditioning circuit conditions the tail-pulse signals from the gamma ray sensor, and a tail-pulse simulator circuit generates a plurality of simulated tail-pulse signals. A computer system processes the tail pulses from the gamma ray sensor and the simulated tail pulses from the tail-pulse simulator circuit. The nuclear sensor is calibrated under the control of the computer. The offset is adjusted using the simulated tail pulses. Since the offset is set to zero or near zero, the sensor gain can be adjusted with a non-hazardous radioactive source such as, for example, naturally occurring radiation and potassium chloride.

  14. Chua's Circuit: Control and Synchronization

    Science.gov (United States)

    Irimiciuc, Stefan-Andrei; Vasilovici, Ovidiu; Dimitriu, Dan-Gheorghe

    Chaos-based data encryption is one of the most reliable methods used in secure communications. This implies a good control of a chaotic system and a good synchronization between the involved systems. Here, experimental results are shown on the control and synchronization of Chua's circuits. The control of the chaotic circuit was achieved by using the switching method. The influence of the control signal characteristics (amplitude, frequency and shape) on the system's states was also investigated. The synchronization of two similar chaotic circuits was studied, emphasizing the importance of the chaotic state characteristics of the Master system in respect to those of Slave system. It was shown that the synchronization does not depend on the chaotic state type, neither on the dimension (x, y or z) used for synchronization.

  15. Additive Manufacturing of Hybrid Circuits

    Science.gov (United States)

    Sarobol, Pylin; Cook, Adam; Clem, Paul G.; Keicher, David; Hirschfeld, Deidre; Hall, Aaron C.; Bell, Nelson S.

    2016-07-01

    There is a rising interest in developing functional electronics using additively manufactured components. Considerations in materials selection and pathways to forming hybrid circuits and devices must demonstrate useful electronic function; must enable integration; and must complement the complex shape, low cost, high volume, and high functionality of structural but generally electronically passive additively manufactured components. This article reviews several emerging technologies being used in industry and research/development to provide integration advantages of fabricating multilayer hybrid circuits or devices. First, we review a maskless, noncontact, direct write (DW) technology that excels in the deposition of metallic colloid inks for electrical interconnects. Second, we review a complementary technology, aerosol deposition (AD), which excels in the deposition of metallic and ceramic powder as consolidated, thick conformal coatings and is additionally patternable through masking. Finally, we show examples of hybrid circuits/devices integrated beyond 2-D planes, using combinations of DW or AD processes and conventional, established processes.

  16. Vertically Integrated Circuits at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Deptuch, Grzegorz; Demarteau, Marcel; Hoff, James; Lipton, Ronald; Shenai, Alpana; Trimpl, Marcel; Yarema, Raymond; Zimmerman, Tom; /Fermilab

    2009-01-01

    The exploration of the vertically integrated circuits, also commonly known as 3D-IC technology, for applications in radiation detection started at Fermilab in 2006. This paper examines the opportunities that vertical integration offers by looking at various 3D designs that have been completed by Fermilab. The emphasis is on opportunities that are presented by through silicon vias (TSV), wafer and circuit thinning and finally fusion bonding techniques to replace conventional bump bonding. Early work by Fermilab has led to an international consortium for the development of 3D-IC circuits for High Energy Physics. The consortium has submitted over 25 different designs for the Fermilab organized MPW run organized for the first time.

  17. Insulation of a synthetic hydrogen metabolism circuit in bacteria

    Directory of Open Access Journals (Sweden)

    Wintermute Edwin H

    2010-02-01

    Full Text Available Abstract Background The engineering of metabolism holds tremendous promise for the production of desirable metabolites, particularly alternative fuels and other highly reduced molecules. Engineering approaches must redirect the transfer of chemical reducing equivalents, preventing these electrons from being lost to general cellular metabolism. This is especially the case for high energy electrons stored in iron-sulfur clusters within proteins, which are readily transferred when two such clusters are brought in close proximity. Iron sulfur proteins therefore require mechanisms to ensure interaction between proper partners, analogous to many signal transduction proteins. While there has been progress in the isolation of engineered metabolic pathways in recent years, the design of insulated electron metabolism circuits in vivo has not been pursued. Results Here we show that a synthetic hydrogen-producing electron transfer circuit in Escherichia coli can be insulated from existing cellular metabolism via multiple approaches, in many cases improving the function of the pathway. Our circuit is composed of heterologously expressed [Fe-Fe]-hydrogenase, ferredoxin, and pyruvate-ferredoxin oxidoreductase (PFOR, allowing the production of hydrogen gas to be coupled to the breakdown of glucose. We show that this synthetic pathway can be insulated through the deletion of competing reactions, rational engineering of protein interaction surfaces, direct protein fusion of interacting partners, and co-localization of pathway components on heterologous protein scaffolds. Conclusions Through the construction and characterization of a synthetic metabolic circuit in vivo, we demonstrate a novel system that allows for predictable engineering of an insulated electron transfer pathway. The development of this system demonstrates working principles for the optimization of engineered pathways for alternative energy production, as well as for understanding how electron

  18. Estrogen receptor coregulators and pioneer factors: The orchestrators of mammary gland cell fate and development

    Directory of Open Access Journals (Sweden)

    Bramanandam eManavathi

    2014-08-01

    Full Text Available The 17-beta estradiol (E2, a steroid hormone, which play critical role in various cellular processes such as cell proliferation, differentiation, migration and apoptosis, is essential for reproduction and mammary gland development. E2 actions are mediated by two classical nuclear hormone receptors, estrogen receptor alpha and beta (ERs. The activity of ERs depends on the coordinate activity of ligand binding, posttranslational modification, and importantly their interaction with their partner proteins called ‘coregulators’. Because majority of breast cancers are ERalpha positive and coregulators are proved to be crucial for ER transcriptional activity, an increased interest in the field has led to the identification of a large number of coregulators. In the last decade, gene knockout studies using mouse models provided impetus to our further understanding of the role of these coregulators in mammary gland development. Several coregulators appear to be critical for terminal end bud formation, ductal branching and alveologenesis during mammary gland development. The emerging studies support that, in addition to these coregulators, the other ER partner proteins ‘pioneering factors’ also seems to contribute significantly to E2 signaling and mammary cell fate. This review discusses emerging themes in coregulator- and pioneering factor-mediated action on ER functions, particularly their role in mammary gland cell fate and development.

  19. NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming

    Directory of Open Access Journals (Sweden)

    Kate E. Hawkins

    2016-03-01

    Full Text Available The potential of induced pluripotent stem cells (iPSCs in disease modeling and regenerative medicine is vast, but current methodologies remain inefficient. Understanding the cellular mechanisms underlying iPSC reprogramming, such as the metabolic shift from oxidative to glycolytic energy production, is key to improving its efficiency. We have developed a lentiviral reporter system to assay longitudinal changes in cell signaling and transcription factor activity in living cells throughout iPSC reprogramming of human dermal fibroblasts. We reveal early NF-κB, AP-1, and NRF2 transcription factor activation prior to a temporal peak in hypoxia inducible factor α (HIFα activity. Mechanistically, we show that an early burst in oxidative phosphorylation and elevated reactive oxygen species generation mediates increased NRF2 activity, which in turn initiates the HIFα-mediated glycolytic shift and may modulate glucose redistribution to the pentose phosphate pathway. Critically, inhibition of NRF2 by KEAP1 overexpression compromises metabolic reprogramming and results in reduced efficiency of iPSC colony formation.

  20. Biology of bone and how it orchestrates the form and function of the skeleton

    Science.gov (United States)

    Sommerfeldt, D. W.; Rubin, C. T.

    2001-01-01

    The principal role of the skeleton is to provide structural support for the body. While the skeleton also serves as the body's mineral reservoir, the mineralized structure is the very basis of posture, opposes muscular contraction resulting in motion, withstands functional load bearing, and protects internal organs. Although the mass and morphology of the skeleton is defined, to some extent, by genetic determinants, it is the tissue's ability to remodel--the local resorption and formation of bone--which is responsible for achieving this intricate balance between competing responsibilities. The aim of this review is to address bone's form-function relationship, beginning with extensive research in the musculoskeletal disciplines, and focusing on several recent cellular and molecular discoveries which help understand the complex interdependence of bone cells, growth factors, physical stimuli, metabolic demands, and structural responsibilities. With a clinical and spine-oriented audience in mind, the principles of bone cell and molecular biology and physiology are presented, and an attempt has been made to incorporate epidemiologic data and therapeutic implications. Bone research remains interdisciplinary by nature, and a deeper understanding of bone biology will ultimately lead to advances in the treatment of diseases and injuries to bone itself.

  1. Integrated circuits for multimedia applications

    DEFF Research Database (Denmark)

    Vandi, Luca

    2007-01-01

    This work presents several key aspects in the design of RF integrated circuits for portable multimedia devices. One chapter is dedicated to the application of negative-feedback topologies to receiver frontends. A novel feedback technique suitable for common multiplier-based mixers is described......, and it is applied to a broad-band dual-loop receiver architecture in order to boost the linearity performances of the stage. A simplified noise- and linearity analysis of the circuit is derived, and a comparison is provided with a more traditional dual-loop topology (a broad-band stage based on shunt...

  2. Fermionic models with superconducting circuits

    Energy Technology Data Exchange (ETDEWEB)

    Las Heras, Urtzi; Garcia-Alvarez, Laura; Mezzacapo, Antonio; Lamata, Lucas [University of the Basque Country UPV/EHU, Department of Physical Chemistry, Bilbao (Spain); Solano, Enrique [University of the Basque Country UPV/EHU, Department of Physical Chemistry, Bilbao (Spain); IKERBASQUE, Basque Foundation for Science, Bilbao (Spain)

    2015-12-01

    We propose a method for the efficient quantum simulation of fermionic systems with superconducting circuits. It consists in the suitable use of Jordan-Wigner mapping, Trotter decomposition, and multiqubit gates, be with the use of a quantum bus or direct capacitive couplings. We apply our method to the paradigmatic cases of 1D and 2D Fermi-Hubbard models, involving couplings with nearest and next-nearest neighbours. Furthermore, we propose an optimal architecture for this model and discuss the benchmarking of the simulations in realistic circuit quantum electrodynamics setups. (orig.)

  3. Circuit modeling for electromagnetic compatibility

    CERN Document Server

    Darney, Ian B

    2013-01-01

    Very simply, electromagnetic interference (EMI) costs money, reduces profits, and generally wreaks havoc for circuit designers in all industries. This book shows how the analytic tools of circuit theory can be used to simulate the coupling of interference into, and out of, any signal link in the system being reviewed. The technique is simple, systematic and accurate. It enables the design of any equipment to be tailored to meet EMC requirements. Every electronic system consists of a number of functional modules interconnected by signal links and power supply lines. Electromagnetic interference

  4. Simplified design of filter circuits

    CERN Document Server

    Lenk, John

    1999-01-01

    Simplified Design of Filter Circuits, the eighth book in this popular series, is a step-by-step guide to designing filters using off-the-shelf ICs. The book starts with the basic operating principles of filters and common applications, then moves on to describe how to design circuits by using and modifying chips available on the market today. Lenk's emphasis is on practical, simplified approaches to solving design problems.Contains practical designs using off-the-shelf ICsStraightforward, no-nonsense approachHighly illustrated with manufacturer's data sheets

  5. Embedded systems circuits and programming

    CERN Document Server

    Sanchez, Julio

    2012-01-01

    During the development of an engineered product, developers often need to create an embedded system--a prototype--that demonstrates the operation/function of the device and proves its viability. Offering practical tools for the development and prototyping phases, Embedded Systems Circuits and Programming provides a tutorial on microcontroller programming and the basics of embedded design. The book focuses on several development tools and resources: Standard and off-the-shelf components, such as input/output devices, integrated circuits, motors, and programmable microcontrollers The implementat

  6. Endogenous money, circuits and financialization

    OpenAIRE

    Malcolm Sawyer

    2013-01-01

    This paper locates the endogenous money approach in a circuitist framework. It argues for the significance of the credit creation process for the evolution of the economy and the absence of any notion of ‘neutrality of money’. Clearing banks are distinguished from other financial institutions as the providers of initial finance in a circuit whereas other financial institutions operate in a final finance circuit. Financialization is here viewed in terms of the growth of financial assets an...

  7. Circuit, Thermal and Cost Characteristics of Impulse Magnetizing Circuits

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper describes the development of circuit, thermal and cost model for a capacitor discharge impulse megnetizer and compares simulations to measurements from an actual system. We used a cost structure consisting of five major subsystems for cost modeling. Especially, we estimated the potential for cost reductions impulse magnetizer as a function of time using the learning curve.

  8. An Approach to Simplify Reversible Logic Circuits

    Directory of Open Access Journals (Sweden)

    Pabitra Roy

    2012-09-01

    Full Text Available Energy loss is one of the major problems in traditional irreversible circuits. For every bit of information loss kTln2 joules of heat is lost. In order to reduce the energy loss the concept of reversible logic circuits are introduced. Here we have described an algorithm for simplifying the reversible logic circuit and hence reduction of circuit cost and energy. The algorithm considers sub_circuit with respect to their number of lines and contiguous gates. The resulting sub_circuits are re-synthesized with smaller equivalent implementation. The process continues until circuit cost reaches good enough for Application or until a given computation budget has been exhausted. The circuit is constructed by NOT, CNOT and Toffoli gates only. By applying the algorithm and using the equivalent implementation we will get significant reduction of circuit cost and hence energy.

  9. Relaxation Based Electrical Simulation for VLSI Circuits

    Directory of Open Access Journals (Sweden)

    S. Rajkumar

    2012-06-01

    Full Text Available Electrical circuit simulation was one of the first CAD tools developed for IC design. The conventional circuit simulators like SPICE and ASTAP were designed initially for the cost effective analysis of circuits containing a few hundred transistors or less. A number of approaches have been used to improve the performances of congenital circuit simulators for the analysis of large circuits. Thereafter relaxation methods was proposed to provide more accurate waveforms than standard circuit simulators with up to two orders of magnitude speed improvement for large circuits. In this paper we have tried to highlights recently used waveform and point relaxation techniques for simulation of VLSI circuits. We also propose a simple parallelization technique and experimentally demonstrate that we can solve digital circuits with tens of million transistors in a few hours.

  10. Retropath: automated pipeline for embedded metabolic circuits.

    Science.gov (United States)

    Carbonell, Pablo; Parutto, Pierre; Baudier, Claire; Junot, Christophe; Faulon, Jean-Loup

    2014-08-15

    Metabolic circuits are a promising alternative to other conventional genetic circuits as modular parts implementing functionalities required for synthetic biology applications. To date, metabolic design has been mainly focused on production circuits. Emergent applications such as smart therapeutics, however, require circuits that enable sensing and regulation. Here, we present RetroPath, an automated pipeline for embedded metabolic circuits that explores the circuit design space from a given set of specifications and selects the best circuits to implement based on desired constraints. Synthetic biology circuits embedded in a chassis organism that are capable of controlling the production, processing, sensing, and the release of specific molecules were enumerated in the metabolic space through a standard procedure. In that way, design and implementation of applications such as therapeutic circuits that autonomously diagnose and treat disease, are enabled, and their optimization is streamlined.

  11. Cellular image classification

    CERN Document Server

    Xu, Xiang; Lin, Feng

    2017-01-01

    This book introduces new techniques for cellular image feature extraction, pattern recognition and classification. The authors use the antinuclear antibodies (ANAs) in patient serum as the subjects and the Indirect Immunofluorescence (IIF) technique as the imaging protocol to illustrate the applications of the described methods. Throughout the book, the authors provide evaluations for the proposed methods on two publicly available human epithelial (HEp-2) cell datasets: ICPR2012 dataset from the ICPR'12 HEp-2 cell classification contest and ICIP2013 training dataset from the ICIP'13 Competition on cells classification by fluorescent image analysis. First, the reading of imaging results is significantly influenced by one’s qualification and reading systems, causing high intra- and inter-laboratory variance. The authors present a low-order LP21 fiber mode for optical single cell manipulation and imaging staining patterns of HEp-2 cells. A focused four-lobed mode distribution is stable and effective in optical...

  12. Multiuser Cellular Network

    CERN Document Server

    Bao, Yi; Chen, Ming

    2011-01-01

    Modern radio communication is faced with a problem about how to distribute restricted frequency to users in a certain space. Since our task is to minimize the number of repeaters, a natural idea is enlarging coverage area. However, coverage has restrictions. First, service area has to be divided economically as repeater's coverage is limited. In this paper, our fundamental method is to adopt seamless cellular network division. Second, underlying physics content in frequency distribution problem is interference between two close frequencies. Consequently, we choose a proper frequency width of 0.1MHz and a relevantly reliable setting to apply one frequency several times. We make a few general assumptions to simplify real situation. For instance, immobile users yield to homogenous distribution; repeaters can receive and transmit information in any given frequency in duplex operation; coverage is mainly decided by antenna height. Two models are built up to solve 1000 users and 10000 users situations respectively....

  13. Engineering Cellular Metabolism.

    Science.gov (United States)

    Nielsen, Jens; Keasling, Jay D

    2016-03-10

    Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals. However, making cells into efficient factories is challenging because cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways that resist efforts to divert resources. Here, we will review the current status and challenges of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation.

  14. Digital circuit boards mach 1 GHz

    CERN Document Server

    Morrison, Ralph

    2012-01-01

    A unique, practical approach to the design of high-speed digital circuit boards The demand for ever-faster digital circuit designs is beginning to render the circuit theory used by engineers ineffective. Digital Circuit Boards presents an alternative to the circuit theory approach, emphasizing energy flow rather than just signal interconnection to explain logic circuit behavior. The book shows how treating design in terms of transmission lines will ensure that the logic will function, addressing both storage and movement of electrical energy on these lines. It cove

  15. Advanced circuit simulation using Multisim workbench

    CERN Document Server

    Báez-López, David; Cervantes-Villagómez, Ofelia Delfina

    2012-01-01

    Multisim is now the de facto standard for circuit simulation. It is a SPICE-based circuit simulator which combines analog, discrete-time, and mixed-mode circuits. In addition, it is the only simulator which incorporates microcontroller simulation in the same environment. It also includes a tool for printed circuit board design.Advanced Circuit Simulation Using Multisim Workbench is a companion book to Circuit Analysis Using Multisim, published by Morgan & Claypool in 2011. This new book covers advanced analyses and the creation of models and subcircuits. It also includes coverage of transmissi

  16. Clocking Scheme for Switched-Capacitor Circuits

    DEFF Research Database (Denmark)

    Steensgaard-Madsen, Jesper

    1998-01-01

    A novel clocking scheme for switched-capacitor (SC) circuits is presented. It can enhance the understanding of SC circuits and the errors caused by MOSFET (MOS) switches. Charge errors, and techniques to make SC circuits less sensitive to them are discussed.......A novel clocking scheme for switched-capacitor (SC) circuits is presented. It can enhance the understanding of SC circuits and the errors caused by MOSFET (MOS) switches. Charge errors, and techniques to make SC circuits less sensitive to them are discussed....

  17. A circuit mechanism for neurodegeneration.

    Science.gov (United States)

    Roselli, Francesco; Caroni, Pico

    2012-10-12

    How deficiency in SMN1 selectively affects motoneurons in spinal muscular atrophy is poorly understood. Here, Imlach et al. and Lotti et al. show that aberrant splicing of Stasimon in cholinergic sensory neurons and interneurons leads to motoneuron degeneration, suggesting that altered circuit function may underlie the disorder.

  18. Integrated Circuit Stellar Magnitude Simulator

    Science.gov (United States)

    Blackburn, James A.

    1978-01-01

    Describes an electronic circuit which can be used to demonstrate the stellar magnitude scale. Six rectangular light-emitting diodes with independently adjustable duty cycles represent stars of magnitudes 1 through 6. Experimentally verifies the logarithmic response of the eye. (Author/GA)

  19. Activity-dependent modulation of neural circuit synaptic connectivity

    Directory of Open Access Journals (Sweden)

    Charles R Tessier

    2009-07-01

    Full Text Available In many nervous systems, the establishment of neural circuits is known to proceed via a two-stage process; 1 early, activity-independent wiring to produce a rough map characterized by excessive synaptic connections, and 2 subsequent, use-dependent pruning to eliminate inappropriate connections and reinforce maintained synapses. In invertebrates, however, evidence of the activity-dependent phase of synaptic refinement has been elusive, and the dogma has long been that invertebrate circuits are “hard-wired” in a purely activity-independent manner. This conclusion has been challenged recently through the use of new transgenic tools employed in the powerful Drosophila system, which have allowed unprecedented temporal control and single neuron imaging resolution. These recent studies reveal that activity-dependent mechanisms are indeed required to refine circuit maps in Drosophila during precise, restricted windows of late-phase development. Such mechanisms of circuit refinement may be key to understanding a number of human neurological diseases, including developmental disorders such as Fragile X syndrome (FXS and autism, which are hypothesized to result from defects in synaptic connectivity and activity-dependent circuit function. This review focuses on our current understanding of activity-dependent synaptic connectivity in Drosophila, primarily through analyzing the role of the fragile X mental retardation protein (FMRP in the Drosophila FXS disease model. The particular emphasis of this review is on the expanding array of new genetically-encoded tools that are allowing cellular events and molecular players to be dissected with ever greater precision and detail.

  20. Social Status-Dependent Shift in Neural Circuit Activation Affects Decision Making.

    Science.gov (United States)

    Miller, Thomas H; Clements, Katie; Ahn, Sungwoo; Park, Choongseok; Hye Ji, Eoon; Issa, Fadi A

    2017-02-22

    In a social group, animals make behavioral decisions that fit their social ranks. These behavioral choices are dependent on the various social cues experienced during social interactions. In vertebrates, little is known of how social status affects the underlying neural mechanisms regulating decision-making circuits that drive competing behaviors. Here, we demonstrate that social status in zebrafish (Danio rerio) influences behavioral decisions by shifting the balance in neural circuit activation between two competing networks (escape and swim). We show that socially dominant animals enhance activation of the swim circuit. Conversely, social subordinates display a decreased activation of the swim circuit, but an enhanced activation of the escape circuit. In an effort to understand how social status mediates these effects, we constructed a neurocomputational model of the escape and swim circuits. The model replicates our findings and suggests that social status-related shift in circuit dynamics could be mediated by changes in the relative excitability of the escape and swim networks. Together, our results reveal that changes in the excitabilities of the Mauthner command neuron for escape and the inhibitory interneurons that regulate swimming provide a cellular mechanism for the nervous system to adapt to changes in social conditions by permitting the animal to select a socially appropriate behavioral response.SIGNIFICANCE STATEMENT Understanding how social factors influence nervous system function is of great importance. Using zebrafish as a model system, we demonstrate how social experience affects decision making to enable animals to produce socially appropriate behavior. Based on experimental evidence and computational modeling, we show that behavioral decisions reflect the interplay between competing neural circuits whose activation thresholds shift in accordance with social status. We demonstrate this through analysis of the behavior and neural circuit

  1. The voltage-current relationship and equivalent circuit implementation of parallel flux-controlled memristive circuits

    Institute of Scientific and Technical Information of China (English)

    Bao Bo-Cheng; Feng Fei; Dong Wei; Pan Sai-Hu

    2013-01-01

    A flux-controlled memristor characterized by smooth cubic nonlinearity is taken as an example,upon which the voltage-current relationships (VCRs) between two parallel memristive circuits-a parallel memristor and capacitor circuit (the parallel MC circuit),and a parallel memristor and inductor circuit (the parallel ML circuit)-are investigated.The results indicate that the VCR between these two parallel memristive circuits is closely related to the circuit parameters,and the frequency and amplitude of the sinusoidal voltage stimulus.An equivalent circuit model of the memristor is built,upon which the circuit simulations and experimental measurements of both the parallel MC circuit and the parallel ML circuit are performed,and the results verify the theoretical analysis results.

  2. Asynchronous Rate Chaos in Spiking Neuronal Circuits

    Science.gov (United States)

    Harish, Omri; Hansel, David

    2015-01-01

    The brain exhibits temporally complex patterns of activity with features similar to those of chaotic systems. Theoretical studies over the last twenty years have described various computational advantages for such regimes in neuronal systems. Nevertheless, it still remains unclear whether chaos requires specific cellular properties or network architectures, or whether it is a generic property of neuronal circuits. We investigate the dynamics of networks of excitatory-inhibitory (EI) spiking neurons with random sparse connectivity operating in the regime of balance of excitation and inhibition. Combining Dynamical Mean-Field Theory with numerical simulations, we show that chaotic, asynchronous firing rate fluctuations emerge generically for sufficiently strong synapses. Two different mechanisms can lead to these chaotic fluctuations. One mechanism relies on slow I-I inhibition which gives rise to slow subthreshold voltage and rate fluctuations. The decorrelation time of these fluctuations is proportional to the time constant of the inhibition. The second mechanism relies on the recurrent E-I-E feedback loop. It requires slow excitation but the inhibition can be fast. In the corresponding dynamical regime all neurons exhibit rate fluctuations on the time scale of the excitation. Another feature of this regime is that the population-averaged firing rate is substantially smaller in the excitatory population than in the inhibitory population. This is not necessarily the case in the I-I mechanism. Finally, we discuss the neurophysiological and computational significance of our results. PMID:26230679

  3. Fabric circuits and method of manufacturing fabric circuits

    Science.gov (United States)

    Chu, Andrew W. (Inventor); Dobbins, Justin A. (Inventor); Scully, Robert C. (Inventor); Trevino, Robert C. (Inventor); Lin, Greg Y. (Inventor); Fink, Patrick W. (Inventor)

    2011-01-01

    A flexible, fabric-based circuit comprises a non-conductive flexible layer of fabric and a conductive flexible layer of fabric adjacent thereto. A non-conductive thread, an adhesive, and/or other means may be used for attaching the conductive layer to the non-conductive layer. In some embodiments, the layers are attached by a computer-driven embroidery machine at pre-determined portions or locations in accordance with a pre-determined attachment layout before automated cutting. In some other embodiments, an automated milling machine or a computer-driven laser using a pre-designed circuit trace as a template cuts the conductive layer so as to separate an undesired portion of the conductive layer from a desired portion of the conductive layer. Additional layers of conductive fabric may be attached in some embodiments to form a multi-layer construct.

  4. Developing a Domain Model for Relay Circuits

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2009-01-01

    the statics as well as the dynamics of relay circuits, i.e. how a relay circuit can be composed legally from electrical components as well as how the components may change state over time. Finally the circuit model is transformed into an executable model, and we show how a concrete circuit can be defined......In this paper we stepwise develop a domain model for relay circuits as used in railway control systems. First we provide an abstract, property-oriented model of networks consisting of components that can be glued together with connectors. This model is strongly inspired by a network model...... for railways madeby Bjørner et.al., however our model is more general: the components can be of any kind and can later be refined to e.g. railway components or circuit components. Then we show how the abstract network model can be refined into an explicit model for relay circuits. The circuit model describes...

  5. Driver circuit for solid state light sources

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, Fred; Denvir, Kerry; Allen, Steven

    2016-02-16

    A driver circuit for a light source including one or more solid state light sources, a luminaire including the same, and a method of so driving the solid state light sources are provided. The driver circuit includes a rectifier circuit that receives an alternating current (AC) input voltage and provides a rectified AC voltage. The driver circuit also includes a switching converter circuit coupled to the light source. The switching converter circuit provides a direct current (DC) output to the light source in response to the rectified AC voltage. The driver circuit also includes a mixing circuit, coupled to the light source, to switch current through at least one solid state light source of the light source in response to each of a plurality of consecutive half-waves of the rectified AC voltage.

  6. Design and Analysis of Adders using Nanotechnology Based Quantum dot Cellular Automata

    Directory of Open Access Journals (Sweden)

    S. K. Lakshmi

    2011-01-01

    Full Text Available Problem statement: The area and complexity are the major issues in circuit design. Here, we propose different types of adder designs based on Quantum dot Cellular Automata (QCA that reduces number of QCA cells and area compare to previous designs. The quantum dot cellular automata is a novel computing paradigm in nanotechnology that can implement digital circuits with faster speed, smaller size and low power consumption. By taking the advantages of QCA we are able to design interesting computational architectures. The QCA cell is a basic building block of nanotechnology that can be used to make gates, wires and memories. The basic logic circuits used in this technology are the inverter and the Majority Gate (MG, using this other logical circuits can be designed. Approach: In this paper, the adders such as half, full and serial bit were designed and analyzed. These structures were designed with minimum number of cells by using cell minimization techniques. The techniques are (1 using two cells inverter and (2 suitable arrangement of cells without overlapping of neighboring cells. The proposed method can be used to minimize area and complexity. Results: These circuits were designed by majority gate and implemented by QCA cells. Then, they simulated using QCA Designer. The simulated results were verified according to the truth table. Conclusion: The performance analyses of those circuits are compared according to complexity, area and number of clock cycles and are also compared with previous designs.

  7. Efficient Radio Resource Allocation in a GSM and GPRS Cellular Network

    Directory of Open Access Journals (Sweden)

    David Vannucci

    2004-10-01

    Full Text Available This paper investigates the effect of various radio resource allocation strategies in a GSM/GPRS cellular network. The most efficient resource allocation is analysed as a function of the proportion of circuit switched voice and packet switched data load. The Grade of Service and average packet delay is investigated as a function of the load, packet size and call duration. Additionally, the feasibility of using voice over Internet Protocol as opposed to circuit switched voice is investigated as a means to increase subscriber capacity per base station. The work is motivated firstly by the complexity of having both circuit switched and packet switched connectivity on GSM/GPRS mobile cellular system and secondly that an exclusively packet based access on GSM/GPRS has the potential to increase the efficiency of resource utilisation by suitably varying the channel allocation to exploit the characteristics of voice and data traffic.

  8. Brain-machine interface circuits and systems

    CERN Document Server

    Zjajo, Amir

    2016-01-01

    This book provides a complete overview of significant design challenges in respect to circuit miniaturization and power reduction of the neural recording system, along with circuit topologies, architecture trends, and (post-silicon) circuit optimization algorithms. The introduced novel circuits for signal conditioning, quantization, and classification, as well as system configurations focus on optimized power-per-area performance, from the spatial resolution (i.e. number of channels), feasible wireless data bandwidth and information quality to the delivered power of implantable system.

  9. Solid-State dc Circuit Breaker

    Science.gov (United States)

    Harvey, P.

    1983-01-01

    Circuit breaker with no moving parts protects direct-current (dc) loads. Current which circuit breaker opens (trip current) is adjustable and so is time delay before breaker trips. Forward voltage drop rises from 0.6 to 1.2 V as current rises to trip point. Breaker has two terminals, like fuse, therefore replaces fuse in dc circuit. Powered by circuit it protects and reset by either turning off power source or disconnecting load.

  10. An Improved Squaring Circuit for Binary Numbers

    Directory of Open Access Journals (Sweden)

    Kabiraj Sethi

    2012-02-01

    Full Text Available In this paper, a high speed squaring circuit for binary numbers is proposed. High speed Vedic multiplier is used for design of the proposed squaring circuit. The key to our success is that only one Vedic multiplier is used instead of four multipliers reported in the literature. In addition, one squaring circuit is used twice. Our proposed Squaring Circuit seems to have better performance in terms of speed.

  11. DC operating points of transistor circuits

    Science.gov (United States)

    Trajkovic, Ljiljana

    Finding a circuit's dc operating points is an essential step in its design and involves solving systems of nonlinear algebraic equations. Of particular research and practical interests are dc analysis and simulation of electronic circuits consisting of bipolar junction and field-effect transistors (BJTs and FETs), which are building blocks of modern electronic circuits. In this paper, we survey main theoretical results related to dc operating points of transistor circuits and discuss numerical methods for their calculation.

  12. Cellular bioluminescence imaging.

    Science.gov (United States)

    Welsh, David K; Noguchi, Takako

    2012-08-01

    Bioluminescence imaging of live cells has recently been recognized as an important alternative to fluorescence imaging. Fluorescent probes are much brighter than bioluminescent probes (luciferase enzymes) and, therefore, provide much better spatial and temporal resolution and much better contrast for delineating cell structure. However, with bioluminescence imaging there is virtually no background or toxicity. As a result, bioluminescence can be superior to fluorescence for detecting and quantifying molecules and their interactions in living cells, particularly in long-term studies. Structurally diverse luciferases from beetle and marine species have been used for a wide variety of applications, including tracking cells in vivo, detecting protein-protein interactions, measuring levels of calcium and other signaling molecules, detecting protease activity, and reporting circadian clock gene expression. Such applications can be optimized by the use of brighter and variously colored luciferases, brighter microscope optics, and ultrasensitive, low-noise cameras. This article presents a review of how bioluminescence differs from fluorescence, its applications to cellular imaging, and available probes, optics, and detectors. It also gives practical suggestions for optimal bioluminescence imaging of single cells.

  13. Cellular neurothekeoma with melanocytosis.

    Science.gov (United States)

    Wu, Ren-Chin; Hsieh, Yi-Yueh; Chang, Yi-Chin; Kuo, Tseng-Tong

    2008-02-01

    Cellular neurothekeoma (CNT) is a benign dermal tumor mainly affecting the head and neck and the upper extremities. It is characterized histologically by interconnecting fascicles of plump spindle or epithelioid cells with ample cytoplasm infiltrating in the reticular dermis. The histogenesis of CNT has been controversial, although it is generally regarded as an immature counterpart of classic/myxoid neurothekeoma, a tumor with nerve sheath differentiation. Two rare cases of CNT containing melanin-laden cells were described. Immunohistochemical study with NKI/C3, vimentin, epithelial membrane antigen, smooth muscle antigen, CD34, factor XIIIa, collagen type IV, S100 protein and HMB-45 was performed. Both cases showed typical growth pattern of CNT with interconnecting fascicles of epithelioid cells infiltrating in collagenous stroma. One of the nodules contained areas exhibiting atypical cytological features. Melanin-laden epithelioid or dendritic cells were diffusely scattered throughout one nodule, and focally present in the peripheral portion of the other nodule. Both nodules were strongly immunoreactive to NKI/C3 and vimentin, but negative to all the other markers employed. CNT harboring melanin-laden cells may pose diagnostic problems because of their close resemblance to nevomelanocytic lesions and other dermal mesenchymal tumors. These peculiar cases may also provide further clues to the histogenesis of CNT.

  14. 30 CFR 75.1323 - Blasting circuits.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Blasting circuits. 75.1323 Section 75.1323... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Explosives and Blasting § 75.1323 Blasting circuits. (a) Blasting circuits shall be protected from sources of stray electric current. (b) Detonators made...

  15. 30 CFR 57.6403 - Branch circuits.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Branch circuits. 57.6403 Section 57.6403... Blasting-Surface and Underground § 57.6403 Branch circuits. (a) If electric blasting includes the use of branch circuits, each branch shall be equipped with a safety switch or equivalent method to isolate...

  16. 49 CFR 234.203 - Control circuits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Control circuits. 234.203 Section 234.203 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., Inspection, and Testing Maintenance Standards § 234.203 Control circuits. All control circuits that...

  17. An Equivalent Circuit for Landau Damping

    DEFF Research Database (Denmark)

    Pécseli, Hans

    1976-01-01

    An equivalent circuit simulating the effect of Landau damping in a stable plasma‐loaded parallel‐plate capacitor is presented. The circuit contains a double infinity of LC components. The transition from stable to unstable plasmas is simulated by the introduction of active elements into the circuit....

  18. 49 CFR 236.721 - Circuit, control.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Circuit, control. 236.721 Section 236.721..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.721 Circuit, control. An electrical circuit between a source of electric energy and a device which it operates....

  19. Controllability/observability analysis of digital circuits

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, L.H.

    1978-11-01

    The testability of a digital circuit is directy related to the difficulty of controlling and observing the logical values of internal nodes from circuit inputs and outputs, respectively. A method for analyzing digital circuits in terms of six functions which characterize combinational and sequential controllability and observability is presented.

  20. Controllability/observability analysis of digital circuits

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, L.H.

    1979-01-01

    The testability of a digital circuit is directly related to the difficulty of controlling and observing the logical values of internal nodes from circuit inputs and outputs, respectively. A method for analyzing digital circuits in terms of six functions which characterize combinational and sequential controllability and observability is presented.

  1. Controllability/observability analysis of digital circuits

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, L.H.

    1979-09-01

    The testability of a digital circuit is directly related to the difficulty of controlling and observing the logical values of internal nodes from circuit inputs and outputs, respectively. A method for analyzing digital circuits in terms of six functions which characterize combinational and sequential controllability and observability is presented.

  2. New Logic Circuit with DC Parametric Excitation

    Science.gov (United States)

    Sugahara, Masanori; Kaneda, Hisayoshi

    1982-12-01

    It is shown that dc parametric excitation is possible in a circuit named JUDO, which is composed of two resistively-connected Josephson junctions. Simulation study proves that the circuit has large gain and properties suitable for the construction of small, high-speed logic circuits.

  3. Nanoelectronic circuit design and test

    Science.gov (United States)

    Simsir, Muzaffer Orkun

    Controlling power consumption in CMOS integrated circuits (ICs) during normal mode of operation is becoming one of the limiting factors to further scaling. In addition, it is a well known fact that during testing of a complex IC, power consumption can far exceed the values reached during its normal operation. High power consumption, combined with limited cooling support, leads to overheating of ICs. This can cause permanent damage to the chip or can invalidate test results due to the fact that extreme temperature variations lead to changes in path delays. Therefore, even good chips can fail the test. For these reasons, thermal problems during test need to be identified to prevent the loss of yield in CMOS ICs. In this thesis, we propose a methodology for thermally characterizing circuits under test. Using this methodology, it is possible to simulate the thermal profiles of the chips during test and prevent possible yield loss because of thermal problems. In addition to the problems associated with power and temperature, a more important barrier is the scaling limitations of the CMOS technology. It has been predicted that in next decade, it will not be possible to scale it further. In the near future, rather than a transition to a completely new technology, extensions to CMOS seem to be more realistic. Double-gate CMOS technology is one of the most promising alternatives that offers a simple extension to CMOS. The transistors of this technology are formed by adding a second gate across the conventional CMOS transistor gate. Designing circuits using this technology has attracted a lot of attention. However, as circuit design methods mature, there is a need to identify how these circuits can be tested. From a circuit testing viewpoint, it is unclear if CMOS fault models are comprehensive enough to model all defects in double-gate CMOS circuits. Therefore, fault models of this technology need to be defined to enable manufacturing-time testing. In this thesis, we

  4. Formation of Neuronal Circuits by Interactions between Neuronal Populations Derived from Different Origins in the Drosophila Visual Center

    Directory of Open Access Journals (Sweden)

    Takumi Suzuki

    2016-04-01

    Full Text Available A wide variety of neurons, including populations derived from different origins, are precisely arranged and correctly connected with their partner to establish a functional neural circuit during brain development. The molecular mechanisms that orchestrate the production and arrangement of these neurons have been obscure. Here, we demonstrate that cell-cell interactions play an important role in establishing the arrangement of neurons of different origins in the Drosophila visual center. Specific types of neurons born outside the medulla primordium migrate tangentially into the developing medulla cortex. During their tangential migration, these neurons express the repellent ligand Slit, and the two layers that the neurons intercalate between express the receptors Robo2 and Robo3. Genetic analysis suggests that Slit-Robo signaling may control the positioning of the layer cells or their processes to form a path for migration. Our results suggest that conserved axon guidance signaling is involved in the interactions between neurons of different origins during brain development.

  5. Cellular and molecular mechanisms of repair in acute and chronic wound healing.

    Science.gov (United States)

    Martin, P; Nunan, R

    2015-08-01

    A considerable understanding of the fundamental cellular and molecular mechanisms underpinning healthy acute wound healing has been gleaned from studying various animal models, and we are now unravelling the mechanisms that lead to chronic wounds and pathological healing including fibrosis. A small cut will normally heal in days through tight orchestration of cell migration and appropriate levels of inflammation, innervation and angiogenesis. Major surgeries may take several weeks to heal and leave behind a noticeable scar. At the extreme end, chronic wounds - defined as a barrier defect that has not healed in 3 months - have become a major therapeutic challenge throughout the Western world and will only increase as our populations advance in age, and with the increasing incidence of diabetes, obesity and vascular disorders. Here we describe the clinical problems and how, through better dialogue between basic researchers and clinicians, we may extend our current knowledge to enable the development of novel potential therapeutic treatments.

  6. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric equipment and circuits; overload and short circuit protection. 75.518 Section 75.518 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection....

  7. Phonon waveguides for electromechanical circuits

    Science.gov (United States)

    Hatanaka, D.; Mahboob, I.; Onomitsu, K.; Yamaguchi, H.

    2014-07-01

    Nanoelectromechanical systems (NEMS), utilizing localized mechanical vibrations, have found application in sensors, signal processors and in the study of macroscopic quantum mechanics. The integration of multiple mechanical elements via electrical or optical means remains a challenge in the realization of NEMS circuits. Here, we develop a phonon waveguide using a one-dimensional array of suspended membranes that offers purely mechanical means to integrate isolated NEMS resonators. We demonstrate that the phonon waveguide can support and guide mechanical vibrations and that the periodic membrane arrangement also creates a phonon bandgap that enables control of the phonon propagation velocity. Furthermore, embedding a phonon cavity into the phonon waveguide allows mobile mechanical vibrations to be dynamically switched or transferred from the waveguide to the cavity, thereby illustrating the viability of waveguide-resonator coupling. These highly functional traits of the phonon waveguide architecture exhibit all the components necessary to permit the realization of all-phononic NEMS circuits.

  8. Handbook of microwave integrated circuits

    Science.gov (United States)

    Hoffmann, Reinmut K.

    The design and operation of ICs for use in the 0.5-20-GHz range are described in an introductory and reference work for industrial engineers. Chapters are devoted to an overview of microwave IC (MIC) technology, general stripline characteristics, microwave transmission line (MTL) parameters for microstrips with isotropic dielectric substrates, higher-order modes on a microstrip, the effects of metallic enclosure on MTL transmission parameters, losses in microstrips, the measurement of MTL parameters, and MTLs on anisotropic dielectric substrates. Consideration is given to coupled microstrips on dielectric substrates, microstrip discontinuities, radiation from microstrip circuits, MTL variations, coplanar MTLs, slotlines, and spurious modes in MTL circuits. Diagrams, drawings, graphs, and a glossary of symbols are provided.

  9. Delay locked loop integrated circuit.

    Energy Technology Data Exchange (ETDEWEB)

    Brocato, Robert Wesley

    2007-10-01

    This report gives a description of the development of a Delay Locked Loop (DLL) integrated circuit (IC). The DLL was developed and tested as a stand-alone IC test chip to be integrated into a larger application specific integrated circuit (ASIC), the Quadrature Digital Waveform Synthesizer (QDWS). The purpose of the DLL is to provide a digitally programmable delay to enable synchronization between an internal system clock and external peripherals with unknown clock skew. The DLL was designed and fabricated in the IBM 8RF process, a 0.13 {micro}m CMOS process. It was designed to operate with a 300MHz clock and has been tested up to 500MHz.

  10. Advanced Microwave Circuits and Systems

    DEFF Research Database (Denmark)

    This book is based on recent research work conducted by the authors dealing with the design and development of active and passive microwave components, integrated circuits and systems. It is divided into seven parts. In the first part comprising the first two chapters, alternative concepts...... and equations for multiport network analysis and characterization are provided. A thru-only de-embedding technique for accurate on-wafer characterization is introduced. The second part of the book corresponds to the analysis and design of ultra-wideband low-noise amplifiers (LNA). The LNA is the most critical...... as sufficient gain in a wide frequency range of operation, which is very difficult to achieve. Most circuits demonstrated are not stable across the frequency band, which makes these amplifiers prone to self-oscillations and therefore limit their applicability. The trade-off between noise figure, gain, linearity...

  11. Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

    Directory of Open Access Journals (Sweden)

    Ryan Barnes

    2017-01-01

    Full Text Available Precise duplication of the human genome is challenging due to both its size and sequence complexity. DNA polymerase errors made during replication, repair or recombination are central to creating mutations that drive cancer and aging. Here, we address the regulation of human DNA polymerases, specifically how human cells orchestrate DNA polymerases in the face of stress to complete replication and maintain genome stability. DNA polymerases of the B-family are uniquely adept at accurate genome replication, but there are numerous situations in which one or more additional DNA polymerases are required to complete genome replication. Polymerases of the Y-family have been extensively studied in the bypass of DNA lesions; however, recent research has revealed that these polymerases play important roles in normal human physiology. Replication stress is widely cited as contributing to genome instability, and is caused by conditions leading to slowed or stalled DNA replication. Common Fragile Sites epitomize “difficult to replicate” genome regions that are particularly vulnerable to replication stress, and are associated with DNA breakage and structural variation. In this review, we summarize the roles of both the replicative and Y-family polymerases in human cells, and focus on how these activities are regulated during normal and perturbed genome replication.

  12. Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.

    Science.gov (United States)

    Barnes, Ryan; Eckert, Kristin

    2017-01-06

    Precise duplication of the human genome is challenging due to both its size and sequence complexity. DNA polymerase errors made during replication, repair or recombination are central to creating mutations that drive cancer and aging. Here, we address the regulation of human DNA polymerases, specifically how human cells orchestrate DNA polymerases in the face of stress to complete replication and maintain genome stability. DNA polymerases of the B-family are uniquely adept at accurate genome replication, but there are numerous situations in which one or more additional DNA polymerases are required to complete genome replication. Polymerases of the Y-family have been extensively studied in the bypass of DNA lesions; however, recent research has revealed that these polymerases play important roles in normal human physiology. Replication stress is widely cited as contributing to genome instability, and is caused by conditions leading to slowed or stalled DNA replication. Common Fragile Sites epitomize "difficult to replicate" genome regions that are particularly vulnerable to replication stress, and are associated with DNA breakage and structural variation. In this review, we summarize the roles of both the replicative and Y-family polymerases in human cells, and focus on how these activities are regulated during normal and perturbed genome replication.

  13. The orchestration of processes in relation to the product, and the role of psychological variables in written composition

    Directory of Open Access Journals (Sweden)

    María-Lourdes Álvarez-Fernández

    2015-01-01

    Full Text Available We studied the timing of writing processes using a direct retrospective online technique, and differences in the textual product from the earliest school years where such a study is feasible to the final years of compulsory education. We also analysed a range of psychological variables to determine their modulating effect on writing. Participants comprised a highly purified sample of 348 students aged between 9 and 16 years old who presented standard development and average levels of curricular and writing competence. Our results reveal complex patterns in the development of the writing process and its orchestration, compared with the textual product, and no direct relationship was observed between development of the writing process and its timing, and improvement in the textual product. Among the youngest students, all this was mediated by psychological variables related to the existence of inaccurate perceptions of self-efficacy as regards the deployment and use of writing processes and causal attributions to external factors. The implications, limitations and future perspectives are discussed.

  14. Monolithic readout circuits for RHIC

    Energy Technology Data Exchange (ETDEWEB)

    O`Connor, P.; Harder, J. [Brookhaven National Laboratory, Upton, NY (United States)

    1991-12-31

    Several CMOS ASICs have been developed for a proposed RHIC experiment. This paper discusses why ASIC implementation was chosen for certain functions, circuit specifications and the design techniques used to meet them, and results of simulations and early prototypes. By working closely together from an early stage in the planning process, in-house ASIC designers and detector and data acquisition experimenters can achieve optimal use of this important technology.

  15. Counterpulse railgun energy recovery circuit

    Energy Technology Data Exchange (ETDEWEB)

    Honig, Emanuel M. (Los Alamos, NM)

    1986-01-01

    In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, a counterpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  16. Overpulse railgun energy recovery circuit

    Energy Technology Data Exchange (ETDEWEB)

    Honig, Emanuel M. (Los Alamos, NM)

    1989-01-01

    In an electromagnetic launcher such as a railgun for propelling a projectile at high velocity, an overpulse energy recovery circuit is employed to transfer stored inductive energy from a source inductor to the railgun inductance to propel the projectile down the railgun. Switching circuitry and an energy transfer capacitor are used to switch the energy back to the source inductor in readiness for a repetitive projectile propelling cycle.

  17. Optimization of Bootstrapping in Circuits

    OpenAIRE

    Benhamouda, Fabrice; Lepoint, Tancrède; Mathieu, Claire; Zhou, Hang

    2016-01-01

    In 2009, Gentry proposed the first Fully Homomorphic Encryption (FHE) scheme, an extremely powerful cryptographic primitive that enables to perform computations, i.e., to evaluate circuits, on encrypted data without decrypting them first. This has many applications, in particular in cloud computing. In all currently known FHE schemes, encryptions are associated to some (non-negative integer) noise level, and at each evaluation of an AND gate, the noise level increases. This is problematic bec...

  18. Coulomb drag in quantum circuits

    OpenAIRE

    Levchenko, Alex; Kamenev, Alex

    2008-01-01

    We study drag effect in a system of two electrically isolated quantum point contacts (QPC), coupled by Coulomb interactions. Drag current exhibits maxima as a function of QPC gate voltages when the latter are tuned to the transitions between quantized conductance plateaus. In the linear regime this behavior is due to enhanced electron-hole asymmetry near an opening of a new conductance channel. In the non-linear regime the drag current is proportional to the shot noise of the driving circuit,...

  19. Two-photon holographic optogenetics of neural circuits (Conference Presentation)

    Science.gov (United States)

    Yang, Weijian; Carrillo-Reid, Luis; Peterka, Darcy S.; Yuste, Rafael

    2016-03-01

    Optical manipulation of in vivo neural circuits with cellular resolution could be important for understanding cortical function. Despite recent progress, simultaneous optogenetic activation with cellular precision has either been limited to 2D planes, or a very small numbers of neurons over a limited volume. Here we demonstrate a novel paradigm for simultaneous 3D activation using a low repetition rate pulse-amplified fiber laser system and a spatial light modulator (SLM) to project 3D holographic excitation patterns on the cortex of mice in vivo for targeted volumetric 3D photoactivation. This method is compatible with two-photon imaging, and enables the simultaneous activation of multiple cells in 3D, using red-shifted opsins, such as C1V1 or ReaChR, while simultaneously imaging GFP-based sensors such as GCaMP6. This all-optical imaging and 3D manipulation approach achieves simultaneous reading and writing of cortical activity, and should be a powerful tool for the study of neuronal circuits.

  20. Ultra-low power integrated circuit design circuits, systems, and applications

    CERN Document Server

    Li, Dongmei; Wang, Zhihua

    2014-01-01

    This book describes the design of CMOS circuits for ultra-low power consumption including analog, radio frequency (RF), and digital signal processing circuits (DSP). The book addresses issues from circuit and system design to production design, and applies the ultra-low power circuits described to systems for digital hearing aids and capsule endoscope devices. Provides a valuable introduction to ultra-low power circuit design, aimed at practicing design engineers; Describes all key building blocks of ultra-low power circuits, from a systems perspective; Applies circuits and systems described to real product examples such as hearing aids and capsule endoscopes.

  1. CMOS circuit design, layout and simulation

    CERN Document Server

    Baker, R Jacob

    2010-01-01

    The Third Edition of CMOS Circuit Design, Layout, and Simulation continues to cover the practical design of both analog and digital integrated circuits, offering a vital, contemporary view of a wide range of analog/digital circuit blocks including: phase-locked-loops, delta-sigma sensing circuits, voltage/current references, op-amps, the design of data converters, and much more. Regardless of one's integrated circuit (IC) design skill level, this book allows readers to experience both the theory behind, and the hands-on implementation of, complementary metal oxide semiconductor (CMOS) IC design via detailed derivations, discussions, and hundreds of design, layout, and simulation examples.

  2. Free fall and cellular automata

    Directory of Open Access Journals (Sweden)

    Pablo Arrighi

    2016-03-01

    Full Text Available Three reasonable hypotheses lead to the thesis that physical phenomena can be described and simulated with cellular automata. In this work, we attempt to describe the motion of a particle upon which a constant force is applied, with a cellular automaton, in Newtonian physics, in Special Relativity, and in General Relativity. The results are very different for these three theories.

  3. About Strongly Universal Cellular Automata

    Directory of Open Access Journals (Sweden)

    Maurice Margenstern

    2013-09-01

    Full Text Available In this paper, we construct a strongly universal cellular automaton on the line with 11 states and the standard neighbourhood. We embed this construction into several tilings of the hyperbolic plane and of the hyperbolic 3D space giving rise to strongly universal cellular automata with 10 states.

  4. Reactive Programming of Cellular Automata

    OpenAIRE

    Boussinot, Frédéric

    2004-01-01

    Implementation of cellular automata using reactive programming gives a way to code cell behaviors in an abstract and modular way. Multiprocessing also becomes possible. The paper describes the implementation of cellular automata with the reactive programming language LOFT, a thread-based extension of C. Self replicating loops considered in artificial life are coded to show the interest of the approach.

  5. A Novel Architecture for Quantum-Dot Cellular Automata Multiplexer

    Directory of Open Access Journals (Sweden)

    Arman Roohi

    2011-11-01

    Full Text Available Quantum-dot Cellular Automata (QCA technology is attractive due to its low power consumption, fast speed and small dimension; therefore it is a promising alternative to CMOS technology. Additionally, multiplexer is a useful part in many important circuits. In this paper we propose a novel design of 2:1 MUX in QCA. Moreover, a 4:1 multiplexer, an XOR gate and a latch are proposed based on our 2:1 multiplexer design. The simulation results have been verified using the QCADesigner.

  6. Interleukin-1 and Interferon-γ Orchestrate β-Glucan-Activated Human Dendritic Cell Programming via IκB-ζ Modulation

    OpenAIRE

    2014-01-01

    Recognition of microbial components via innate receptors including the C-type lectin receptor Dectin-1, together with the inflammatory environment, programs dendritic cells (DCs) to orchestrate the magnitude and type of adaptive immune responses. The exposure to β-glucan, a known Dectin-1 agonist and component of fungi, yeasts, and certain immune support supplements, activates DCs to induce T helper (Th)17 cells that are essential against fungal pathogens and extracellular bacteria but may tr...

  7. COML (Classroom Orchestration Modelling Language) and Scenarios Designer: Toolsets to Facilitate Collaborative Learning in a One-to-One Technology Classroom

    OpenAIRE

    Niramitranon, Jitti; Sharples, Mike; Greenhalgh, Chris

    2006-01-01

    In a one-to-one collaborative learning classroom supported by ubiquitous computing, teachers require tools that allow them to design of learning scenarios, and to manage and monitor the activities happening in the classroom. Our project proposes an architecture for a classroom management system and a scenarios designer tool, both based on a Classroom Orchestration Modelling Language (COML), to support these requirements. We are developing and testing this with the GroupScribbles software usin...

  8. MIMO Communication for Cellular Networks

    CERN Document Server

    Huang, Howard; Venkatesan, Sivarama

    2012-01-01

    As the theoretical foundations of multiple-antenna techniques evolve and as these multiple-input multiple-output (MIMO) techniques become essential for providing high data rates in wireless systems, there is a growing need to understand the performance limits of MIMO in practical networks. To address this need, MIMO Communication for Cellular Networks presents a systematic description of MIMO technology classes and a framework for MIMO system design that takes into account the essential physical-layer features of practical cellular networks. In contrast to works that focus on the theoretical performance of abstract MIMO channels, MIMO Communication for Cellular Networks emphasizes the practical performance of realistic MIMO systems. A unified set of system simulation results highlights relative performance gains of different MIMO techniques and provides insights into how best to use multiple antennas in cellular networks under various conditions. MIMO Communication for Cellular Networks describes single-user,...

  9. Design of superconductor frame compression circuits

    Science.gov (United States)

    Sakurai, T.; Miyaho, N.; Miyahara, K.

    2007-10-01

    We proposed previously a novel interface circuit which was used between semiconductor data-input circuits and superconductor high-speed routers. The frame length of data packets is compressed in the interface circuit. Our proposed interface circuit has rather narrow timing margin. The problem was that our control circuit of the interface circuit could allow only very small timing delay. In this paper we propose a modified control circuit. We have improved the timing margin of the control circuit using RS-flip flop (RS-FF), where two shift registers and one control circuit are driven by clock pulses provided from a master clock-pulse generator. In this circuit, we have assumed fixed frame length packets. Our final target of master clock frequency is 100 GHz which will be realized with the device-parameter set of future advanced process. As the first step of realizing this target value, we aimed at 40 GHz clock operation with the conventional device-parameter set of NECs standard I process. The behavior of the whole frame compression circuit was simulated by a computer, and it was confirmed that it operated properly up to the master clock frequency of 23 GHz.

  10. Graphene radio frequency receiver integrated circuit.

    Science.gov (United States)

    Han, Shu-Jen; Garcia, Alberto Valdes; Oida, Satoshi; Jenkins, Keith A; Haensch, Wilfried

    2014-01-01

    Graphene has attracted much interest as a future channel material in radio frequency electronics because of its superior electrical properties. Fabrication of a graphene integrated circuit without significantly degrading transistor performance has proven to be challenging, posing one of the major bottlenecks to compete with existing technologies. Here we present a fabrication method fully preserving graphene transistor quality, demonstrated with the implementation of a high-performance three-stage graphene integrated circuit. The circuit operates as a radio frequency receiver performing signal amplification, filtering and downconversion mixing. All circuit components are integrated into 0.6 mm(2) area and fabricated on 200 mm silicon wafers, showing the unprecedented graphene circuit complexity and silicon complementary metal-oxide-semiconductor process compatibility. The demonstrated circuit performance allow us to use graphene integrated circuit to perform practical wireless communication functions, receiving and restoring digital text transmitted on a 4.3-GHz carrier signal.

  11. Fractional linear systems and electrical circuits

    CERN Document Server

    Kaczorek, Tadeusz

    2015-01-01

    This monograph covers some selected problems of positive and fractional electrical circuits composed of resistors, coils, capacitors and voltage (current) sources. The book consists of 8 chapters, 4 appendices and a list of references. Chapter 1 is devoted to fractional standard and positive continuous-time and discrete-time linear systems without and with delays. In chapter 2 the standard and positive fractional electrical circuits are considered and the fractional electrical circuits in transient states are analyzed.  Descriptor linear electrical circuits and their properties are investigated in chapter 3,  while chapter 4 is devoted to the stability of fractional standard and positive linear electrical circuits. The reachability, observability and reconstructability of fractional positive electrical circuits and their decoupling zeros are analyzed in chapter 5. The fractional linear electrical circuits with feedbacks are considered in chapter 6. In chapter 7 solutions of minimum energy control for standa...

  12. Dynamic Topology Re-Configuration in Multihop Cellular Networks Using Sequential Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    B.Shantha Kumari

    2014-10-01

    Full Text Available Cellular communications has experienced explosive growth in the past two decades. Today millions of people around the world use cellular phones. Cellular phones allow a person to make or receive a call from almost anywhere. Likewise, a person is allowed to continue the phone conversation while on the move. Cellular communications is supported by an infrastructure called a cellular network, which integrates cellular phones into the public switched telephone network. The cellular network has gone through three generations.The first generation of cellular networks is analog in nature. To accommodate more cellular phone subscribers, digital TDMA (time division multiple access and CDMA (code division multiple access technologies are used in the second generation (2G to increase the network capacity. With digital technologies, digitized voice can be coded and encrypted. Therefore, the 2G cellular network is also more secure. The third generation (3G integrates cellular phones into the Internet world by providing highspeed packet-switching data transmission in addition to circuit-switching voice transmission. The 3G cellular networks have been deployed in some parts of Asia, Europe, and the United States since 2002 and will be widely deployed in the coming years. The high increase in traffic and data rate for future generations of mobile communication systems, with simultaneous requirement for reduced power consumption, makes Multihop Cellular Networks (MCNs an attractive technology. To exploit the potentials of MCNs a new network paradigm is proposed in this paper. In addition, a novel sequential genetic algorithm (SGA is proposed as a heuristic approximation to reconfigure the optimum relaying topology as the network traffic changes. Network coding is used to combine the uplink and downlink transmissions, and incorporate it into the optimum bidirectional relaying with ICI awareness. Numerical results have shown that the algorithms suggested in this

  13. Lower Bounds for Tropical Circuits and Dynamic Programs

    OpenAIRE

    Jukna, Stasys

    2014-01-01

    Tropical circuits are circuits with Min and Plus, or Max and Plus operations as gates. Their importance stems from their intimate relation to dynamic programming algorithms. The power of tropical circuits lies somewhere between that of monotone boolean circuits and monotone arithmetic circuits. In this paper we present some lower bounds arguments for tropical circuits, and hence, for dynamic programs.

  14. 46 CFR 111.54-1 - Circuit breakers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Circuit breakers. 111.54-1 Section 111.54-1 Shipping... REQUIREMENTS Circuit Breakers § 111.54-1 Circuit breakers. (a) Each Circuit breaker must— (1) Meet the general... circuit breaker frame. (e) Each circuit breaker located in an engineroom, boilerroom, or machinery......

  15. 14 CFR 23.1357 - Circuit protective devices.

    Science.gov (United States)

    2010-01-01

    ... circuit breakers, must be installed in all electrical circuits other than— (1) Main circuits of starter... circuit breaker or replace a fuse is essential to safety in flight, that circuit breaker or fuse must be... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Circuit protective devices. 23.1357...

  16. Study and Simulation of Traffic Behavior in Cellular Network

    Science.gov (United States)

    Madhup, D. K.; Shrestha, C. L.; Sharma, R. K.

    2007-07-01

    Cellular radio systems accommodate a large number of users with a limited radio spectrum. The concept of trunking allows a large number of users to share the relatively small number of channels in a cell by providing access to each user, on demand, from a pool of available channels. Traffic engineering deals with provisioning of communication circuits in a given area for a number of subscribers with a required grade of service. Traffic in any cell depends upon the number of users, the average request rate and average call duration. Certain number of channels is required for the required GOS. To design an optimum capacity cellular system, traffic behavior on that system is important. The number of channel required can be estimated by using Erlang formula and Erlang table. Erlang table is not always useful to calculate the probability of blocking in various complex scenarios such as channel borrowing strategies. When the total number of channel available in a given cell are divided to serve partly for newly generated calls and partly for handover calls, and if they use dynamic channel assignment strategies like channel borrowing, then the probability of blocking can't be calculated from Erlang table. Simulation model of the behavior help us to determine the blocking and the channel utilization while using various channel assignment strategies. The title "Study and Simulation of Traffic Behavior in Cellular Network" entail the study of the blocking probability of traffic in cellular network for static channel assignment strategies and dynamic channel borrowing strategies through MATLAB programming language and graphic user interface (GUI). The result shows that the dynamic scheme can perform better than static maximizing the overall utilization of the circuits and minimizing the overall blocking.

  17. Noncoding RNAs and HIV: viral manipulation of host dark matter to shape the cellular environment

    Directory of Open Access Journals (Sweden)

    Samantha eBarichievy

    2015-03-01

    Full Text Available On October 28th 1943 Winston Churchill said we shape our buildings, and afterwards our buildings shape us (Humes, 1994. Churchill was pondering how and when to rebuild the British House of Commons, which had been destroyed by enemy bombs on May 10th 1941. The old House had been small and insufficient to hold all its members, but was restored to its original form in 1950 in order to recapture the convenience and dignity that the building had shaped into its parliamentary members. The circular loop whereby buildings or dwellings are shaped and go on to shape those that reside in them is also true of pathogens and their hosts. As obligate parasites, pathogens need to alter their cellular host environments to ensure survival. Typically pathogens modify cellular transcription profiles and in doing so, the pathogen in turn is affected, thereby closing the loop. As key orchestrators of gene expression, noncoding RNAs provide a vast and extremely precise set of tools for pathogens to target in order to shape the cellular environment. This review will focus on host noncoding RNAs that are manipulated by the infamous intracellular pathogen, the Human Immunodeficiency Virus (HIV. We will briefly describe both short and long host noncoding RNAs and discuss how HIV gains control of these factors to ensure widespread dissemination throughout the host as well as the establishment of lifelong, chronic infection.

  18. Cellular systems biology profiling applied to cellular models of disease.

    Science.gov (United States)

    Giuliano, Kenneth A; Premkumar, Daniel R; Strock, Christopher J; Johnston, Patricia; Taylor, Lansing

    2009-11-01

    Building cellular models of disease based on the approach of Cellular Systems Biology (CSB) has the potential to improve the process of creating drugs as part of the continuum from early drug discovery through drug development and clinical trials and diagnostics. This paper focuses on the application of CSB to early drug discovery. We discuss the integration of protein-protein interaction biosensors with other multiplexed, functional biomarkers as an example in using CSB to optimize the identification of quality lead series compounds.

  19. Quantum-dot cellular automata based reversible low power parity generator and parity checker design for nanocommunication

    Institute of Scientific and Technical Information of China (English)

    Jadav Chandra DAS; Debashis DE

    2016-01-01

    Quantum-dot cellular automata (QCA) is an emerging area of research in reversible computing. It can be used to design nanoscale circuits. In nanocommunication, the detection and correction of errors in a received message is a major factor. Besides, device density and power dissipation are the key issues in the nanocommunication architecture. For the first time, QCA-based designs of the reversible low-power odd parity generator and odd parity checker using the Feynman gate have been achieved in this study. Using the proposed parity generator and parity checker circuit, a nanocommunication architecture is pro-posed. The detection of errors in the received message during transmission is also explored. The proposed QCA Feynman gate outshines the existing ones in terms of area, cell count, and delay. The quantum costs of the proposed conventional reversible circuits and their QCA layouts are calculated and compared, which establishes that the proposed QCA circuits have very low quantum cost compared to conventional designs. The energy dissipation by the layouts is estimated, which ensures the possibility of QCA nano-device serving as an alternative platform for the implementation of reversible circuits. The stability of the proposed circuits under thermal randomness is analyzed, showing the operational efficiency of the circuits. The simulation results of the proposed design are tested with theoretical values, showing the accuracy of the circuits. The proposed circuits can be used to design more complex low-power nanoscale lossless nanocommunication architecture such as nano-transmitters and nano-receivers.

  20. Is the audiologic status of professional musicians a reflection of the noise exposure in classical orchestral music?

    Science.gov (United States)

    Emmerich, Edeltraut; Rudel, Lars; Richter, Frank

    2008-07-01

    The sound in classical orchestral music is louder than noise emissions allowed by national rules in industry. We wanted to assess the audiologic status of professional musicians at different ages of their careers and to look for a coherence of declined hearing ability and the sound emissions in order to substantiate advices for hearing protection and occupational medicine in musicians. Data from questionnaires (anamnestic data on sound exposure in profession and leisure times, use of hearing protection, self-evaluation of hearing function and hearing deficits), audiometric data and amplitudes of OAE were evaluated from 109 professional musicians aged 30-69 years from three major German orchestras and from 110 students of an academy of music (aged 11-19 years). Sound emissions of the whole orchestra and of single instruments/instrument groups were measured at the orchestra stages and pits during rehearsals and performances. None of the musicians was engaged in noisy hobbies and only a few used hearing protectors regularly. More than 50% of the musicians had a hearing loss of 15 dB(A) and more. Highest losses were found among the strings and the brass players. DPOAE amplitudes coincidently declined with the duration of performing music in the orchestras. Professional musicians aged older than 60 years had a significantly greater hearing loss at 4 and 6 kHz than those aged 30-39 years. Among the strings in one orchestra a dominant hearing deficit in the left ears was observed. Musicians need the same health care for their hearing as workers in noisy industry. A better education on the hearing hazards (use of hearing protectors) as well as sound protection in the rehearsal rooms is necessary. Hearing loss in professional musicians should be accepted as an occupational disease.

  1. Quantum Memristors with Superconducting Circuits

    Science.gov (United States)

    Salmilehto, J.; Deppe, F.; Di Ventra, M.; Sanz, M.; Solano, E.

    2017-01-01

    Memristors are resistive elements retaining information of their past dynamics. They have garnered substantial interest due to their potential for representing a paradigm change in electronics, information processing and unconventional computing. Given the advent of quantum technologies, a design for a quantum memristor with superconducting circuits may be envisaged. Along these lines, we introduce such a quantum device whose memristive behavior arises from quasiparticle-induced tunneling when supercurrents are cancelled. For realistic parameters, we find that the relevant hysteretic behavior may be observed using current state-of-the-art measurements of the phase-driven tunneling current. Finally, we develop suitable methods to quantify memory retention in the system. PMID:28195193

  2. Model reduction for circuit simulation

    CERN Document Server

    Hinze, Michael; Maten, E Jan W Ter

    2011-01-01

    Simulation based on mathematical models plays a major role in computer aided design of integrated circuits (ICs). Decreasing structure sizes, increasing packing densities and driving frequencies require the use of refined mathematical models, and to take into account secondary, parasitic effects. This leads to very high dimensional problems which nowadays require simulation times too large for the short time-to-market demands in industry. Modern Model Order Reduction (MOR) techniques present a way out of this dilemma in providing surrogate models which keep the main characteristics of the devi

  3. Recursive Optimization of Digital Circuits

    Science.gov (United States)

    1990-12-14

    capability will become increasingly important as the application-specific integrated circuit (ASIC) market continues to meet its rapid growth projections... market (ASIC) continues to grow (18). The recursive optimization system presented in this thesis was developed to inves- tigate a new approach to global...f)) (narg (bar arg)) (fO (divide f narg)) (f1 (divide f arg)) (gO (divide g narg)) (gi (divide g arg)) ( productO (mult fO gO)) (producti (mult fl gl

  4. Circuit for Driving Piezoelectric Transducers

    Science.gov (United States)

    Randall, David P.; Chapsky, Jacob

    2009-01-01

    The figure schematically depicts an oscillator circuit for driving a piezoelectric transducer to excite vibrations in a mechanical structure. The circuit was designed and built to satisfy application-specific requirements to drive a selected one of 16 such transducers at a regulated amplitude and frequency chosen to optimize the amount of work performed by the transducer and to compensate for both (1) temporal variations of the resonance frequency and damping time of each transducer and (2) initially unknown differences among the resonance frequencies and damping times of different transducers. In other words, the circuit is designed to adjust itself to optimize the performance of whichever transducer is selected at any given time. The basic design concept may be adaptable to other applications that involve the use of piezoelectric transducers in ultrasonic cleaners and other apparatuses in which high-frequency mechanical drives are utilized. This circuit includes three resistor-capacitor networks that, together with the selected piezoelectric transducer, constitute a band-pass filter having a peak response at a frequency of about 2 kHz, which is approximately the resonance frequency of the piezoelectric transducers. Gain for generating oscillations is provided by a power hybrid operational amplifier (U1). A junction field-effect transistor (Q1) in combination with a resistor (R4) is used as a voltage-variable resistor to control the magnitude of the oscillation. The voltage-variable resistor is part of a feedback control loop: Part of the output of the oscillator is rectified and filtered for use as a slow negative feedback to the gate of Q1 to keep the output amplitude constant. The response of this control loop is much slower than 2 kHz and, therefore, does not introduce significant distortion of the oscillator output, which is a fairly clean sine wave. The positive AC feedback needed to sustain oscillations is derived from sampling the current through the

  5. Circuit Breakers and Market Runs

    OpenAIRE

    Sarah Draus; Mark Van Achter

    2012-01-01

    This paper analyzes whether the application of a “circuit breaker” to a financial market (i.e. a mechanism that interrupts trading for a predetermined period when the price moves beyond a predetermined level) reaches its intended goals of increased market stability and overall welfare. Our framework of analysis is a model in which investors can trade at several dates and might face a liquidity shock forcing them to sell immediately when the shock occurs. This setting potentially induces a “ma...

  6. Circuit considerations for repetitive railguns

    Energy Technology Data Exchange (ETDEWEB)

    Honih, E.M.

    1986-01-01

    Railgun electromagnetic launchers have significant military and scientific potential. They provide direct conversion of electrical energy to projectile kinetic energy, and they offer the hope of achieving projectile velocities greatly exceeding the limits of conventional guns. With over 10 km/sec already demonstrated, railguns are attracting attention for tactical and strategic weapons systems and for scientific equation-of-state research. The full utilization of railguns will require significant improvements in every aspect of system design - projectile, barrel, and power source - to achieve operation on a large scale. This paper will review fundamental aspects of railguns, with emphasis on circuit considerations and repetitive operation.

  7. Circuit QED with transmon qubits

    Energy Technology Data Exchange (ETDEWEB)

    Wulschner, Karl Friedrich; Puertas, Javier; Baust, Alexander; Eder, Peter; Fischer, Michael; Goetz, Jan; Haeberlein, Max; Schwarz, Manuel; Xie, Edwar; Zhong, Ling; Deppe, Frank; Fedorov, Kirill; Marx, Achim; Menzel, Edwin; Gross, Rudolf [Walther-Meissner-Institut, Bayerische Akademie der Wissenschaften, Garching (Germany); Physik-Department, TU Muenchen, Garching (Germany); Nanosystems Initiative Munich (NIM), Muenchen (Germany); Huebl, Hans [Walther-Meissner-Institut, Bayerische Akademie der Wissenschaften, Garching (Germany); Nanosystems Initiative Munich (NIM), Muenchen (Germany); Weides, Martin [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany)

    2015-07-01

    Superconducting quantum bits are basic building blocks for circuit QED systems. Applications in the fields of quantum computation and quantum simulation require long coherence times. We have fabricated and characterized superconducting transmon qubits which are designed to operate at a high ratio of Josephson energy and charging energy. Due to their low sensitivity to charge noise transmon qubits show good coherence properties. We couple transmon qubits to coplanar waveguide resonators and coplanar slotline resonators and characterize the devices at mK-temperatures. From the experimental data we derive the qubit-resonator coupling strength, the qubit relaxation time and calibrate the photon number in the resonator via Stark shifts.

  8. Quantum Memristors with Superconducting Circuits

    Science.gov (United States)

    Salmilehto, J.; Deppe, F.; di Ventra, M.; Sanz, M.; Solano, E.

    2017-02-01

    Memristors are resistive elements retaining information of their past dynamics. They have garnered substantial interest due to their potential for representing a paradigm change in electronics, information processing and unconventional computing. Given the advent of quantum technologies, a design for a quantum memristor with superconducting circuits may be envisaged. Along these lines, we introduce such a quantum device whose memristive behavior arises from quasiparticle-induced tunneling when supercurrents are cancelled. For realistic parameters, we find that the relevant hysteretic behavior may be observed using current state-of-the-art measurements of the phase-driven tunneling current. Finally, we develop suitable methods to quantify memory retention in the system.

  9. Radio frequency integrated circuit design

    CERN Document Server

    Rogers, John W M

    2010-01-01

    This newly revised and expanded edition of the 2003 Artech House classic, Radio Frequency Integrated Circuit Design, serves as an up-to-date, practical reference for complete RFIC know-how. The second edition includes numerous updates, including greater coverage of CMOS PA design, RFIC design with on-chip components, and more worked examples with simulation results. By emphasizing working designs, this book practically transports you into the authors' own RFIC lab so you can fully understand the function of each design detailed in this book. Among the RFIC designs examined are RF integrated LC

  10. HF radio systems and circuits

    CERN Document Server

    Sabin, William

    1998-01-01

    A comprehensive reference for the design of high frequency communications systems and equipment. This revised edition is loaded with practical data, much of which cannot be found in other reference books. Its approach to the subject follows the needs of an engineer from system definition and performance requirements down to the individual circuit elements that make up radio transmitters and receivers. The accompanying disk contains updated software on filters, matching networks and receiver analysis. SciTech Publishing also provides many other products related to Communication Systems Design.

  11. A Course in Cellular Bioengineering.

    Science.gov (United States)

    Lauffenburger, Douglas A.

    1989-01-01

    Gives an overview of a course in chemical engineering entitled "Cellular Bioengineering," dealing with how chemical engineering principles can be applied to molecular cell biology. Topics used are listed and some key references are discussed. Listed are 85 references. (YP)

  12. Energy Landscape of Cellular Networks

    Science.gov (United States)

    Wang, Jin

    2008-03-01

    Cellular Networks are in general quite robust and perform their biological functions against the environmental perturbations. Progresses have been made from experimental global screenings, topological and engineering studies. However, there are so far few studies of why the network should be robust and perform biological functions from global physical perspectives. In this work, we will explore the global properties of the network from physical perspectives. The aim of this work is to develop a conceptual framework and quantitative physical methods to study the global nature of the cellular network. The main conclusion of this presentation is that we uncovered the underlying energy landscape for several small cellular networks such as MAPK signal transduction network and gene regulatory networks, from the experimentally measured or inferred inherent chemical reaction rates. The underlying dynamics of these networks can show bi-stable as well as oscillatory behavior. The global shapes of the energy landscapes of the underlying cellular networks we have studied are robust against perturbations of the kinetic rates and environmental disturbances through noise. We derived a quantitative criterion for robustness of the network function from the underlying landscape. It provides a natural explanation of the robustness and stability of the network for performing biological functions. We believe the robust landscape is a global universal property for cellular networks. We believe the robust landscape is a quantitative realization of Darwinian principle of natural selection at the cellular network level. It may provide a novel algorithm for optimizing the network connections, which is crucial for the cellular network design and synthetic biology. Our approach is general and can be applied to other cellular networks.

  13. GLITCH ANALYSIS AND REDUCTION IN DIGITAL CIRCUITS

    Directory of Open Access Journals (Sweden)

    Ronak Shah

    2016-08-01

    Full Text Available Hazard in digital circuits is unnecessary transitions due to gate propagation delay in that circuit. Hazards occur due to uneven delay offered in the path of the various ongoing signals. One of the important reasons for power dissipation in CMOS circuits is the switching activity .This include activities such as spurious pulses, called glitches. Power optimization techniques that concentrate on the reduction of switching power dissipation of a given circuit are called glitch reduction techniques. In this paper, we analyse various Glitch reduction techniques such as Hazard filtering Technique, Balanced Path Technique, Multiple Threshold Technique and Gate Freezing Technique. We also measure the parameters such as noise and delay of the circuits on application of various techniques to check the reliability of different circuits in various situations.

  14. A concise guide to chaotic electronic circuits

    CERN Document Server

    Buscarino, Arturo; Frasca, Mattia; Sciuto, Gregorio

    2014-01-01

    This brief provides a source of instruction from which students can be taught about the practicalities of designing and using chaotic circuits. The text provides information on suitable materials, circuit design and schemes for design realization. Readers are then shown how to reproduce experiments on chaos and to design new ones. The text guides the reader easily from the basic idea of chaos to the laboratory test providing an experimental basis that can be developed for such applications as secure communications. This brief provides introductory information on sample chaotic circuits, includes coverage of their development, and the “gallery” section provides information on a wide range of circuits. Concise Guide to Chaotic Electronic Circuits will be useful to anyone running a laboratory class involving chaotic circuits and to students wishing to learn about them.

  15. Development of larval motor circuits in Drosophila.

    Science.gov (United States)

    Kohsaka, Hiroshi; Okusawa, Satoko; Itakura, Yuki; Fushiki, Akira; Nose, Akinao

    2012-04-01

    How are functional neural circuits formed during development? Despite recent advances in our understanding of the development of individual neurons, little is known about how complex circuits are assembled to generate specific behaviors. Here, we describe the ways in which Drosophila motor circuits serve as an excellent model system to tackle this problem. We first summarize what has been learned during the past decades on the connectivity and development of component neurons, in particular motor neurons and sensory feedback neurons. We then review recent progress in our understanding of the development of the circuits as well as studies that apply optogenetics and other innovative techniques to dissect the circuit diagram. New approaches using Drosophila as a model system are now making it possible to search for developmental rules that regulate the construction of neural circuits.

  16. A Singularity in the Kirchhoff's Circuit Equations

    CERN Document Server

    Harsha, N R Sree

    2016-01-01

    Students often have difficulty in understanding qualitatively the behaviour of simple electric circuits. In particular, as different studies have shown, they find multiple batteries connected in multiple loops difficult to analyse. In a recent paper [Phys. Educ. 50 568 (2015)], we showed such an electric circuit, which consists of ideal batteries connected in parallel, that couldn't be solved by the existing circuit analysis methods. In this paper, we shall introduce a new mathematical method of solving simple electric circuits from the solutions of more general circuits and show that the currents, in this particular circuit, take the indeterminate 0/0 form. We shall also present some of the implications of teaching the method. We believe that the description presented in this paper should help the instructors in teaching the behaviour of multiple batteries connected in parallel.

  17. Physical synthesis of quantum circuits using templates

    Science.gov (United States)

    Mirkhani, Zahra; Mohammadzadeh, Naser

    2016-10-01

    Similar to traditional CMOS circuits, quantum circuit design flow is divided into two main processes: logic synthesis and physical design. Addressing the limitations imposed on optimization of the quantum circuit metrics because of no information sharing between logic synthesis and physical design processes, the concept of " physical synthesis" was introduced for quantum circuit flow, and a few techniques were proposed for it. Following that concept, in this paper a new approach for physical synthesis inspired by template matching idea in quantum logic synthesis is proposed to improve the latency of quantum circuits. Experiments show that by using template matching as a physical synthesis approach, the latency of quantum circuits can be improved by more than 23.55 % on average.

  18. Analog VLSI neural network integrated circuits

    Science.gov (United States)

    Kub, F. J.; Moon, K. K.; Just, E. A.

    1991-01-01

    Two analog very large scale integration (VLSI) vector matrix multiplier integrated circuit chips were designed, fabricated, and partially tested. They can perform both vector-matrix and matrix-matrix multiplication operations at high speeds. The 32 by 32 vector-matrix multiplier chip and the 128 by 64 vector-matrix multiplier chip were designed to perform 300 million and 3 billion multiplications per second, respectively. An additional circuit that has been developed is a continuous-time adaptive learning circuit. The performance achieved thus far for this circuit is an adaptivity of 28 dB at 300 KHz and 11 dB at 15 MHz. This circuit has demonstrated greater than two orders of magnitude higher frequency of operation than any previous adaptive learning circuit.

  19. DNA-damage response network at the crossroads of cell-cycle checkpoints,cellular senescence and apoptosis

    Institute of Scientific and Technical Information of China (English)

    SCHMITT Estelle; PAQUET Claudie; BEAUCHEMIN Myriam; BERTRAND Richard

    2007-01-01

    Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation,cellular senescence and cell death.Cells proliferate through a cell cycle that is tightly regulated by cyclin-dependent kinase activities.Cellular senescence is a safeguard program limiting the proliferative competence of cells in living organisms.Apoptosis eliminates unwanted cells by the coordinated activity of gene products that regulate and effect cell death.The intimate link between the cell cycle,cellular senescence,apoptosis regulation,cancer development and tumor responses to cancer treatment has become eminently apparent.Extensive research on tumor suppressor genes,oncogenes,the cell cycle and apoptosis regulatory genes has revealed how the DNA damage-sensing and -signaling pathways,referred to as the DNA-damage response network,are tied to cell proliferation,cell-cycle arrest,cellular senescence and apoptosis.DNA-damage responses are complex,involving "sensor" proteins that sense the damage,and transmit signals to "transducer" proteins,which,in turn,convey the signals to numerous "effector" proteins implicated in specific cellular pathways,including DNA repair mechanisms,cell-cycle checkpoints,cellular senescence and apoptosis.The Bcl-2 family of proteins stands among the most crucial regulators of apoptosis and performs vital functions in deciding whether a cell will live or die after cancer chemotherapy and irradiation.In addition,several studies have now revealed that members of the Bcl-2 family also interface with the cell cycle,DNA repair/recombination and cellular senescence,effects that are generally distinct from their function in apoptosis.In this review,we report progress in understanding the molecular networks that regulate cell-cycle checkpoints,cellular senescence and apoptosis after DNA damage,and discuss the influence of some Bcl-2 family members on cell-cycle checkpoint regulation.

  20. Mathematical Modeling of Cellular Metabolism.

    Science.gov (United States)

    Berndt, Nikolaus; Holzhütter, Hermann-Georg

    2016-01-01

    Cellular metabolism basically consists of the conversion of chemical compounds taken up from the extracellular environment into energy (conserved in energy-rich bonds of organic phosphates) and a wide array of organic molecules serving as catalysts (enzymes), information carriers (nucleic acids), and building blocks for cellular structures such as membranes or ribosomes. Metabolic modeling aims at the construction of mathematical representations of the cellular metabolism that can be used to calculate the concentration of cellular molecules and the rates of their mutual chemical interconversion in response to varying external conditions as, for example, hormonal stimuli or supply of essential nutrients. Based on such calculations, it is possible to quantify complex cellular functions as cellular growth, detoxification of drugs and xenobiotic compounds or synthesis of exported molecules. Depending on the specific questions to metabolism addressed, the methodological expertise of the researcher, and available experimental information, different conceptual frameworks have been established, allowing the usage of computational methods to condense experimental information from various layers of organization into (self-) consistent models. Here, we briefly outline the main conceptual frameworks that are currently exploited in metabolism research.

  1. MESOSCOPIC ELECTRIC CIRCUITS WITH CHARGE DISCRETIZATION

    OpenAIRE

    2004-01-01

    MESOSCOPIC ELECTRIC CIRCUITS WITH CHARGE DISCRETIZATION Nanoscience is a modern aspect of electronic engineering with significant projections for applications on new devices. This project allowed presenting an innovative language and a rigorous vision on aspects of nanoscience. The theory of quantum electrical circuits with discrete charge corresponds to the description (in simple terms) of some aspects of nanoscience. Our results gather aspects of quantum mechanics, electrical circuit...

  2. Nonsmooth Modeling and Simulation for Switched Circuits

    CERN Document Server

    Acary, Vincent; Brogliato, Bernard

    2011-01-01

    "Nonsmooth Modeling and Simulation for Switched Circuits" concerns the modeling and the numerical simulation of switched circuits with the nonsmooth dynamical systems (NSDS) approach, using piecewise-linear and multivalued models of electronic devices like diodes, transistors, switches. Numerous examples (ranging from introductory academic circuits to various types of power converters) are analyzed and many simulation results obtained with the INRIA open-source SICONOS software package are presented. Comparisons with SPICE and hybrid methods demonstrate the power of the NSDS approach

  3. Logarithmic current-measuring transistor circuits

    DEFF Research Database (Denmark)

    Højberg, Kristian Søe

    1967-01-01

    Describes two transistorized circuits for the logarithmic measurement of small currents suitable for nuclear reactor instrumentation. The logarithmic element is applied in the feedback path of an amplifier, and only one dual transistor is used as logarithmic diode and temperature compensating...... transistor. A simple one-amplifier circuit is compared with a two-amplifier system. The circuits presented have been developed in connexion with an amplifier using a dual m.o.s. transistor input stage with diode-protected gates....

  4. Combinational Circuit Obfuscation Through Power Signature Manipulation

    Science.gov (United States)

    2011-06-01

    hardware descrip- tion files such as VHDL , SPICE netlist are needed for the SPICE-like simulation tools; however, the SID just needs a simple circuit...Time Interval) Figure 3.12: The Summary of Procedure for SPICE Simulation CORGI 3.0 XML Exporter Truth Table Exporter GraphML Exporter VHDL Exporter...encryption system developed by Falkinburg [4]. For installing the obfuscated version of a circuit into the test-bed, the circuit is described in VHDL format

  5. The analysis and design of linear circuits

    CERN Document Server

    Thomas, Roland E; Toussaint, Gregory J

    2009-01-01

    The Analysis and Design of Linear Circuits, 6e gives the reader the opportunity to not only analyze, but also design and evaluate linear circuits as early as possible. The text's abundance of problems, applications, pedagogical tools, and realistic examples helps engineers develop the skills needed to solve problems, design practical alternatives, and choose the best design from several competing solutions. Engineers searching for an accessible introduction to resistance circuits will benefit from this book that emphasizes the early development of engineering judgment.

  6. Monitoring transients in low inductance circuits

    Science.gov (United States)

    Guilford, R.P.; Rosborough, J.R.

    1985-10-21

    The instant invention relates to methods of and apparatus for monitoring transients in low inductance circuits and to a probe utilized to practice said method and apparatus. More particularly, the instant invention relates to methods of and apparatus for monitoring low inductance circuits, wherein the low inductance circuits include a pair of flat cable transmission lines. The instant invention is further directed to a probe for use in monitoring pairs of flat cable transmission lines.

  7. Electronic circuits for communications systems: A compilation

    Science.gov (United States)

    1972-01-01

    The compilation of electronic circuits for communications systems is divided into thirteen basic categories, each representing an area of circuit design and application. The compilation items are moderately complex and, as such, would appeal to the applications engineer. However, the rationale for the selection criteria was tailored so that the circuits would reflect fundamental design principles and applications, with an additional requirement for simplicity whenever possible.

  8. Long-wavelength silicon photonic integrated circuits

    OpenAIRE

    2014-01-01

    In this paper we elaborate on our development of silicon photonic integrated circuits operating at wavelengths beyond the telecommunication wavelength window. Silicon-on-insulator waveguide circuits up to 3.8 mu m wavelength are demonstrated as well as germanium-on-silicon waveguide circuits operating in the 5-5 mu m wavelength range. The heterogeneous integration of III-V semiconductors and IV-VI semiconductors on this platform is described for the integration of lasers and photodetectors op...

  9. Efficient FM Algorithm for VLSI Circuit Partitioning

    Directory of Open Access Journals (Sweden)

    M.RAJESH

    2013-04-01

    Full Text Available In FM algorithm initial partitioning matrix of the given circuit is assigned randomly, as a result for larger circuit having hundred or more nodes will take long time to arrive at the final partition if theinitial partitioning matrix is close to the final partitioning then the computation time (iteration required is small . Here we have proposed novel approach to arrive at initial partitioning by using spectralfactorization method the results was verified using several circuits.

  10. Integrated capacitors for conductive lithographic film circuits

    OpenAIRE

    Harrey, PM; Evans, PSA; Harrison, DJ

    2001-01-01

    This paper reports on fabrication of low-value embedded capacitors in conductive lithographic film (CLF) circuit boards. The CLF process is a low-cost and high speed manufacturing technique for flexible circuits and systems. We report on the construction and electrical characteristics of CLF capacitor structures printed onto flexible substrates. These components comprise a single polyester dielectric layer, which separates the printed electrode films. Multilayer circuit boards with printed co...

  11. Hyperchaotic circuit with damped harmonic oscillators

    DEFF Research Database (Denmark)

    Lindberg, Erik; Murali, K.; Tamasevicius, A.

    2001-01-01

    A simple fourth-order hyperchaotic circuit with damped harmonic oscillators is described. ANP3 and PSpice simulations including an eigenvalue study of the linearized Jacobian are presented together with a hardware implementation. The circuit contains two inductors with series resistance, two ideal...... capacitors and one nonlinear active conductor. The Lyapunov exponents are presented to confirm the hyperchaotic nature of the oscillations of the circuit. The nonlinear conductor is realized with a diode. A negative impedance converter and a linear resistor. The performance of the circuit is investigated...

  12. Efficient Scheme for Optimizing Quantum Fourier Circuits

    Institute of Scientific and Technical Information of China (English)

    JIANG Min; ZHANG Zengke; Tzyh-Jong Tarn

    2008-01-01

    In quantum circuits, importing of additional qubits can reduce the operation time and prevent de-coherence induced by the environment. However, excessive qubits may make the quantum system vulner-able. This paper describes how to relax existing qubits without additional qubits to significantly reduce the operation time of the quantum Fourier circuit compared to a circuit without optimization. The results indicate that this scheme makes full use of the qubits relaxation. The concepts can be applied to improve similar quantum circuits and guide the physical implementations of quantum algorithms or devices.

  13. Analog circuit design art, science, and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    Analog Circuit Design: Art, Science, and Personalities discusses the many approaches and styles in the practice of analog circuit design. The book is written in an informal yet informative manner, making it easily understandable to those new in the field. The selection covers the definition, history, current practice, and future direction of analog design; the practice proper; and the styles in analog circuit design. The book also includes the problems usually encountered in analog circuit design; approach to feedback loop design; and other different techniques and applications. The text is

  14. Electric circuit theory applied electricity and electronics

    CERN Document Server

    Yorke, R

    1981-01-01

    Electric Circuit Theory provides a concise coverage of the framework of electrical engineering. Comprised of six chapters, this book emphasizes the physical process of electrical engineering rather than abstract mathematics. Chapter 1 deals with files, circuits, and parameters, while Chapter 2 covers the natural and forced response of simple circuit. Chapter 3 talks about the sinusoidal steady state, and Chapter 4 discusses the circuit analysis. The fifth chapter tackles frequency response of networks, and the last chapter covers polyphase systems. This book will be of great help to electrical

  15. Model Order Reduction for Electronic Circuits:

    DEFF Research Database (Denmark)

    Hjorth, Poul G.; Shontz, Suzanne

    Electronic circuits are ubiquitous; they are used in numerous industries including: the semiconductor, communication, robotics, auto, and music industries (among many others). As products become more and more complicated, their electronic circuits also grow in size and complexity. This increased ...... in the semiconductor industry. Circuit simulation proceeds by using Maxwell’s equations to create a mathematical model of the circuit. The boundary element method is then used to discretize the equations, and the variational form of the equations are then solved on the graph network....

  16. Circuit For Control Of Electromechanical Prosthetic Hand

    Science.gov (United States)

    Bozeman, Richard J., Jr.

    1995-01-01

    Proposed circuit for control of electromechanical prosthetic hand derives electrical control signals from shoulder movements. Updated, electronic version of prosthesis, that includes two hooklike fingers actuated via cables from shoulder harness. Circuit built around favored shoulder harness, provides more dexterous movement, without incurring complexity of computer-controlled "bionic" or hydraulically actuated devices. Additional harness and potentiometer connected to similar control circuit mounted on other shoulder. Used to control stepping motor rotating hand about prosthetic wrist to one of number of angles consistent with number of digital outputs. Finger-control signals developed by circuit connected to first shoulder harness transmitted to prosthetic hand via sliprings at prosthetic wrist joint.

  17. Wafer-scale graphene integrated circuit.

    Science.gov (United States)

    Lin, Yu-Ming; Valdes-Garcia, Alberto; Han, Shu-Jen; Farmer, Damon B; Meric, Inanc; Sun, Yanning; Wu, Yanqing; Dimitrakopoulos, Christos; Grill, Alfred; Avouris, Phaedon; Jenkins, Keith A

    2011-06-10

    A wafer-scale graphene circuit was demonstrated in which all circuit components, including graphene field-effect transistor and inductors, were monolithically integrated on a single silicon carbide wafer. The integrated circuit operates as a broadband radio-frequency mixer at frequencies up to 10 gigahertz. These graphene circuits exhibit outstanding thermal stability with little reduction in performance (less than 1 decibel) between 300 and 400 kelvin. These results open up possibilities of achieving practical graphene technology with more complex functionality and performance.

  18. High Speed Solid State Circuit Breaker

    Science.gov (United States)

    Podlesak, Thomas F.

    1993-01-01

    The U.S. Army Research Laboratory, Fort Monmouth, NJ, has developed and is installing two 3.3 MW high speed solid state circuit breakers at the Army's Pulse Power Center. These circuit breakers will interrupt 4160V three phase power mains in no more than 300 microseconds, two orders of magnitude faster than conventional mechanical contact type circuit breakers. These circuit breakers utilize Gate Turnoff Thyristors (GTO's) and are currently utility type devices using air cooling in an air conditioned enclosure. Future refinements include liquid cooling, either water or two phase organic coolant, and more advanced semiconductors. Each of these refinements promises a more compact, more reliable unit.

  19. The emergy analysis of loop circuit.

    Science.gov (United States)

    Cao, Kai; Feng, Xiao

    2008-12-01

    Emergy analysis can analyze the resource utilization and environmental performance of a system. Loop circuit is a common structure in the process industry, but when emergy analysis is carried out to such structure, mistakes such as emergy double counting often occur. To avoid emergy double counting, two types of loop circuit-direct loop circuit and indirect loop circuit-are theoretically distinguished, and the methods to avoid such mistake are proposed. Finally, PVC production and vinyl acetate production are adopted to demonstrate the methods.

  20. Synapse rearrangements upon learning: from divergent-sparse connectivity to dedicated sub-circuits.

    Science.gov (United States)

    Caroni, Pico; Chowdhury, Ananya; Lahr, Maria

    2014-10-01

    Learning can involve formation of new synapses and loss of synapses, providing memory traces of learned skills. Recent findings suggest that these synapse rearrangements reflect assembly of task-related sub-circuits from initially broadly distributed and sparse connectivity in the brain. These local circuit remodeling processes involve rapid emergence of synapses upon learning, followed by protracted validation involving strengthening of some new synapses, and selective elimination of others. The timing of these consolidation processes can vary. Here, we review these findings, focusing on how molecular/cellular mechanisms of synapse assembly, strengthening, and elimination might interface with circuit/system mechanisms of learning and memory consolidation. An integrated understanding of these learning-related processes should provide a better basis to elucidate how experience, genetic background, and disease influence brain function.

  1. Orchestrating an Exceptional Death

    DEFF Research Database (Denmark)

    Jensen, Anja Marie Bornø

    processes of facing brain death and deciding about organ donation. This study suggests that organ donation should be understood as a ‘strange figure’ challenging traditions and attitudes regarding the boundaries between life and death and the practices surrounding dead human bodies. Simultaneously, organ...... donation can be comforting and furthermore enable some families to make sense of a sudden tragic death. Throughout the thesis, the concept of ‘orchestration’ serves as the overall theoretical framework to understand how families, hospital staff and, on a larger scale, Danish society attempt to perform......, reinterpret and translate death and organ donation into something culturally acceptable and sense making. With chapters focusing analytically on the performance of trust, the transformative practices of hope, the aesthetization of ambiguous bodies, the sociality of exchangeable organs and the organ donation...

  2. Orchestrating intensities and rhythms

    DEFF Research Database (Denmark)

    Staunæs, Dorthe; Juelskjær, Malou

    2016-01-01

    The aim of this article is to trace how contemporary (post)psychologies, when used as psy-leadership tools in order to reach new standards, may create new work around the standards and may also create new subjectivities. It is well known that education is a field in which standardization and the ......The aim of this article is to trace how contemporary (post)psychologies, when used as psy-leadership tools in order to reach new standards, may create new work around the standards and may also create new subjectivities. It is well known that education is a field in which standardization...... and the making of subjects have held sway for many years; and it is also well known that schools have been some of the most regular purchasers of psychological methods, tests and classifications. Following but also elaborating upon governmentality studies, it is suggested that a current shift towards...

  3. Orchestrating an Exceptional Death

    DEFF Research Database (Denmark)

    Jensen, Anja Marie Bornø

    , reinterpret and translate death and organ donation into something culturally acceptable and sense making. With chapters focusing analytically on the performance of trust, the transformative practices of hope, the aesthetization of ambiguous bodies, the sociality of exchangeable organs and the organ donation......This Ph.D. thesis explores the experiences of Danish donor families and the context of organ donation in Denmark. Based on comprehensive ethnographic studies at Danish hospitals and interviews with health care professionals and donor families, readers are invited on a journey into the complex...... processes of facing brain death and deciding about organ donation. This study suggests that organ donation should be understood as a ‘strange figure’ challenging traditions and attitudes regarding the boundaries between life and death and the practices surrounding dead human bodies. Simultaneously, organ...

  4. Orchestration of bone remodeling

    NARCIS (Netherlands)

    Moester, Martiene Johanna Catharina

    2014-01-01

    In healthy individuals, a balance exists between bone formation and resorption. Disruption of this balance can lead to higher or lower bone mass, and disease such as osteoporosis. Treatment for osteoporosis generally inhibits bone resorption, but does not rebuild bone to a healthy strength. More kno

  5. Orchestrating Multiple Intelligences

    Science.gov (United States)

    Moran, Seana; Kornhaber, Mindy; Gardner, Howard

    2006-01-01

    Education policymakers often go astray when they attempt to integrate multiple intelligences theory into schools, according to the originator of the theory, Howard Gardner, and his colleagues. The greatest potential of a multiple intelligences approach to education grows from the concept of a profile of intelligences. Each learner's intelligence…

  6. Orchestrating Lean Implementation

    DEFF Research Database (Denmark)

    Riis, Jens Ove; Mikkelsen, Hans; Andersen, Jesper Rank

    2008-01-01

    The notion of Lean Manufacturing is not merely confined to a set of well defined techniques, but represents a broad approach to managing a company. Working with lean entails many aspects, such as production planning and control, production engineering, product development, supply chain......, and organizational issues. To become effective, many functional areas and departments must be involved. At the same time companies are embedded in a dynamic environment. The aim of the paper is to propose a comprehensive approach to better implementation of lean initiatives, based on two empirical studies. The paper...

  7. Orchestrating intensities and rhythms

    DEFF Research Database (Denmark)

    Staunæs, Dorthe; Juelskjær, Malou

    2016-01-01

    The aim of this article is to trace how contemporary (post)psychologies, when used as psy-leadership tools in order to reach new standards, may create new work around the standards and may also create new subjectivities. It is well known that education is a field in which standardization and the ......The aim of this article is to trace how contemporary (post)psychologies, when used as psy-leadership tools in order to reach new standards, may create new work around the standards and may also create new subjectivities. It is well known that education is a field in which standardization...

  8. Reliability of Physical Systems: Detection of Malicious Subcircuits (Trojan Circuits) in Sequential Circuits

    Science.gov (United States)

    Matrosova, A. Yu.; Kirienko, I. E.; Tomkov, V. V.; Miryutov, A. A.

    2016-12-01

    Reliability of physical systems is provided by reliability of their parts including logical ones. Insertion of malicious subcircuits that can destroy logical circuit or cause leakage of confidential information from a system necessitates the detection of such subcircuits followed by their masking if possible. We suggest a method of finding a set of sequential circuit nodes in which Trojan Circuits can be inserted. The method is based on random estimations of controllability and observability of combinational nodes calculated using a description of sequential circuit working area and an evidence of existence of a transfer sequence for the proper set of internal states without finding the sequence itself. The method allows cutting calculations using operations on Reduced Ordered Binary Decision Diagrams (ROBDDs) that can depend only on the state variables of the circuit. The approach, unlike traditional ones, does not require preliminary sequential circuit simulation but can use its results. It can be used when malicious circuits cannot be detected during sequential circuit verification.

  9. Hierarchical Cellular Structures in High-Capacity Cellular Communication Systems

    CERN Document Server

    Jain, R K; Agrawal, N K

    2011-01-01

    In the prevailing cellular environment, it is important to provide the resources for the fluctuating traffic demand exactly in the place and at the time where and when they are needed. In this paper, we explored the ability of hierarchical cellular structures with inter layer reuse to increase the capacity of mobile communication network by applying total frequency hopping (T-FH) and adaptive frequency allocation (AFA) as a strategy to reuse the macro and micro cell resources without frequency planning in indoor pico cells [11]. The practical aspects for designing macro- micro cellular overlays in the existing big urban areas are also explained [4]. Femto cells are inducted in macro / micro / pico cells hierarchical structure to achieve the required QoS cost effectively.

  10. Effects of Genetic Variation on the E. coli Host-Circuit Interface

    Directory of Open Access Journals (Sweden)

    Stefano Cardinale

    2013-07-01

    Full Text Available Predictable operation of engineered biological circuitry requires the knowledge of host factors that compete or interfere with designed function. Here, we perform a detailed analysis of the interaction between constitutive expression from a test circuit and cell-growth properties in a subset of genetic variants of the bacterium Escherichia coli. Differences in generic cellular parameters such as ribosome availability and growth rate are the main determinants (89% of strain-specific differences of circuit performance in laboratory-adapted strains but are responsible for only 35% of expression variation across 88 mutants of E. coli BW25113. In the latter strains, we identify specific cell functions, such as nitrogen metabolism, that directly modulate circuit behavior. Finally, we expose aspects of carbon metabolism that act in a strain- and sequence-specific manner. This method of dissecting interactions between host factors and heterologous circuits enables the discovery of mechanisms of interference necessary for the development of design principles for predictable cellular engineering.

  11. Cornered by reality: circuit minors

    Directory of Open Access Journals (Sweden)

    José A. Moreno Mena

    2015-01-01

    Full Text Available The present study examines a category of migrant children named “circuit minors.” This category includes unaccompanied migrant children and adolescents who cross the border continuously for various reasons and are typically associated with criminal gangs and human and drug traffickers. The aim of this paper is to highlight the problem and consider the risks and the state of social vulnerability in which this population lives. These categories of children and adolescent migrants are identified through a review of the literature, newspaper archives, and official statistics. The study draws on interviews with key informants to characterize this population. We conclude that there is a need to review existing frameworks for the protection of migrant children and to create an action protocol for officials who have contact with these children to ensure their best interests.

  12. TIME CALIBRATED OSCILLOSCOPE SWEEP CIRCUIT

    Science.gov (United States)

    Smith, V.L.; Carstensen, H.K.

    1959-11-24

    An improved time calibrated sweep circuit is presented, which extends the range of usefulness of conventional oscilloscopes as utilized for time calibrated display applications in accordance with U. S. Patent No. 2,832,002. Principal novelty resides in the provision of a pair of separate signal paths, each of which is phase and amplitude adjustable, to connect a high-frequency calibration oscillator to the output of a sawtooth generator also connected to the respective horizontal deflection plates of an oscilloscope cathode ray tube. The amplitude and phase of the calibration oscillator signals in the two signal paths are adjusted to balance out feedthrough currents capacitively coupled at high frequencies of the calibration oscillator from each horizontal deflection plate to the vertical plates of the cathode ray tube.

  13. Electrical circuit theory and technology

    CERN Document Server

    Bird, John

    2014-01-01

    This much-loved textbook explains the principles of electrical circuit theory and technology so that students of electrical and mechanical engineering can master the subject. Real-world situations and engineering examples put the theory into context. The inclusion of worked problems with solutions help you to learn and further problems then allow you to test and confirm you have fully understood each subject. In total the book contains 800 worked problems, 1000 further problems and 14 revision tests with answers online. This an ideal text for foundation and undergraduate degree students and those on upper level vocational engineering courses, in particular electrical and mechanical. It provides a sound understanding of the knowledge required by technicians in fields such as electrical engineering, electronics and telecommunications. This edition has been updated with developments in key areas such as semiconductors, transistors, and fuel cells, along with brand new material on ABCD parameters and Fourier's An...

  14. Advanced Microwave Circuits and Systems

    DEFF Research Database (Denmark)

    such as voltage-controlled oscillators and electron devices for millimeter wave and submillimeter wave applications. This part also covers studies of integrated buffer circuits. Passive components are indispensable elements of any electronic system. The increasing demands to miniaturization and cost effectiveness...... component in a receiving system. Its performance determines the overall system sensitivity because it is the first block to amplify the received signal from the antenna. Hence, for the achievement of high receiver performance, the LNA is required to have a low noise figure with good input matching as well......, bandwidth, and power consumption, which generally accompanies the LNA design process, is discussed in this part. The requirement from an amplifier design differs for different applications. A power amplifier is a type of amplifier which drives the antenna of a transmitter. Unlike LNA, a power amplifier...

  15. Design of Multivalued Circuits Based on an Algebra for Current—Mode CMOS Multivalued Circuits

    Institute of Scientific and Technical Information of China (English)

    陈偕雄; ClaudioMoraga

    1995-01-01

    An algebra proposed for current-mode CMOS multivalued circuits is briefly reviewed.this paper discusses its application in the design of multivalued circuits.Several current-mode CMOS quaternary and quinary circuits are designed by algebraic means.The design method based on this algebra may offer a design simpler than the previously known ones.

  16. Scaling of graphene integrated circuits

    Science.gov (United States)

    Bianchi, Massimiliano; Guerriero, Erica; Fiocco, Marco; Alberti, Ruggero; Polloni, Laura; Behnam, Ashkan; Carrion, Enrique A.; Pop, Eric; Sordan, Roman

    2015-04-01

    The influence of transistor size reduction (scaling) on the speed of realistic multi-stage integrated circuits (ICs) represents the main performance metric of a given transistor technology. Despite extensive interest in graphene electronics, scaling efforts have so far focused on individual transistors rather than multi-stage ICs. Here we study the scaling of graphene ICs based on transistors from 3.3 to 0.5 μm gate lengths and with different channel widths, access lengths, and lead thicknesses. The shortest gate delay of 31 ps per stage was obtained in sub-micron graphene ROs oscillating at 4.3 GHz, which is the highest oscillation frequency obtained in any strictly low-dimensional material to date. We also derived the fundamental Johnson limit, showing that scaled graphene ICs could be used at high frequencies in applications with small voltage swing.The influence of transistor size reduction (scaling) on the speed of realistic multi-stage integrated circuits (ICs) represents the main performance metric of a given transistor technology. Despite extensive interest in graphene electronics, scaling efforts have so far focused on individual transistors rather than multi-stage ICs. Here we study the scaling of graphene ICs based on transistors from 3.3 to 0.5 μm gate lengths and with different channel widths, access lengths, and lead thicknesses. The shortest gate delay of 31 ps per stage was obtained in sub-micron graphene ROs oscillating at 4.3 GHz, which is the highest oscillation frequency obtained in any strictly low-dimensional material to date. We also derived the fundamental Johnson limit, showing that scaled graphene ICs could be used at high frequencies in applications with small voltage swing. Electronic supplementary information (ESI) available: Discussions on the cutoff frequency fT, the maximum frequency of oscillation fmax, and the intrinsic gate delay CV/I. See DOI: 10.1039/c5nr01126d

  17. Classifying cellular automata using grossone

    Science.gov (United States)

    D'Alotto, Louis

    2016-10-01

    This paper proposes an application of the Infinite Unit Axiom and grossone, introduced by Yaroslav Sergeyev (see [7] - [12]), to the development and classification of one and two-dimensional cellular automata. By the application of grossone, new and more precise nonarchimedean metrics on the space of definition for one and two-dimensional cellular automata are established. These new metrics allow us to do computations with infinitesimals. Hence configurations in the domain space of cellular automata can be infinitesimally close (but not equal). That is, they can agree at infinitely many places. Using the new metrics, open disks are defined and the number of points in each disk computed. The forward dynamics of a cellular automaton map are also studied by defined sets. It is also shown that using the Infinite Unit Axiom, the number of configurations that follow a given configuration, under the forward iterations of cellular automaton maps, can now be computed and hence a classification scheme developed based on this computation.

  18. Prognosis of Different Cellular Generations

    Directory of Open Access Journals (Sweden)

    Preetish Ranjan

    2013-04-01

    Full Text Available Technological advancement in mobile telephony from 1G to 3G, 4G and 5G has a very axiomatic fact that made an entire world a global village. The cellular system employs a different design approach and technology that most commercial radio and television system use. In the cellular system, the service area is divided into cells and a transmitter is designed to serve an individual cell. The system seeks to make efficient use of available channels by using low-power transmitters to allow frequency reuse at a smaller distance. Maximizing the number of times each channel can be reused in a given geographical area is the key to an efficient cellular system design. During the past three decades, the world has seen significant changes in telecommunications industry. There have been some remarkable aspects to the rapid growth in wireless communications, as seen by the large expansion in mobile systems. This paper focuses on “Past, Present & Future of Cellular Telephony” and some light has been thrown upon the technologies of the cellular systems, namely 1G, 2G, 2.5G, 3G and future generations like 4G and 5G systems as well.

  19. Composition Characteristics of Olivier Messiaen’s Later Orchestral Works%梅西安晚期管弦乐作品的创作特征

    Institute of Scientific and Technical Information of China (English)

    汪胜付

    2016-01-01

    Olivier Messiaen (1908~1992 ) was a great French composer of the 20th century. This paper discussed his later orchestral works composed after the 1970s, which were rarely analyzed or studied in China. Main composition characteristics of Messiaen’s last six orchestral works were analyzed and summarized as follows. First-ly, in the aspect of structure thinking, his works used multi-materials, multi-color juxtaposition and symmetry. Secondly, his composition was more extensively influ-enced by synaesthesia. Thirdly, symphonic characteristics of birdsongs were fully demonstrated in his last six orchestral works. Finally, just like his other works, these six works were deeply influenced by religion or relevant themes.%文章选取了国内20世纪法国作曲家奥利维耶·梅西安(Olivier Messiaen,1908~1992)在70年代以后创作的晚期管弦乐作品为研究对象,归纳总结了梅西安晚期的六部管弦乐作品的在创作上的主要特点与整体特征。首先,在结构思维上主要体现出多材料、多色彩并置与对称性。其次,在音乐创作上受到了更宽泛的“联觉”影响。再次,晚期六部管弦乐作品充分表现出鸟歌的交响性。最后,这六部管弦乐作品深远地受到宗教题材影响。

  20. Transformation and Implementation from WS-CDL Choreography to BPEL Orchestration%WS-CDL编排到BPEL编制的转换与实现

    Institute of Scientific and Technical Information of China (English)

    周洁颖; 阮彤; 张弘

    2012-01-01

    Web服务编排流程与编制流程之间的转换一直是学术界的研究热点,尤其是W3C提出的标准规范WS-CDL与如今广泛应用的编制规范BPEL流程之间的转换,对SOA实践者来说具有很强的实用性。然而,现有的转换规则都没有考虑全局模型到局部模型的转换过程中可能存在的不可执行问题,并且其转换规则本身也存在一些不合理的地方。提出了新的WS-CDL编排到BPEL编制流程的转换规则,该规则不但给出了转换过程中不可执行问题的检验和排除方法,并且其转换规则相较于现有的规则更加准确合理。%To transform from service choreography to service orchestration is very useful for SOA practitioners,especially the transformation from the standard WS-CDL to the widely adopted orchestration standard BPEL.However,the existing transformation rules are not accurate in some aspects,and lack verification of enforceability during the transformation from global model to local model.Therefore,this paper proposes a set of transformation rules from WS-CDL choreography to BPEL orchestration with verification of enforceability,which is proved more accurate than the existing rules.

  1. Improved Circuit For Hot-Film Anemometer

    Science.gov (United States)

    Gray, David L.

    1993-01-01

    Circuit suitable for automation or computer control of setup and operation. Hot-film or hot-wire anemometer circuit features individual current drives for two arms of wheatstone bridge, plus other features that provide improved calibration and automated or computer-controlled operation.

  2. Two New Families of Floating FDNR Circuits

    Directory of Open Access Journals (Sweden)

    Ahmed M. Soliman

    2010-01-01

    Full Text Available Two new configurations for realizing ideal floating frequency-dependent negative resistor elements (FDNR are introduced. The proposed circuits are symmetrical and are realizable by four CCII or ICCII or a combination of both. Each configuration is realizable by eight different circuits. Simulation results are included to support the theory.

  3. Electric Circuit Theory--Computer Illustrated Text.

    Science.gov (United States)

    Riches, Brian

    1990-01-01

    Discusses the use of a computer-illustrated text (CIT) with integrated software to teach electric circuit theory to college students. Examples of software use are given, including simple animation, graphical displays, and problem-solving programs. Issues affecting electric circuit theory instruction are also addressed, including mathematical…

  4. Overload-protector/fault-indicator circuit

    Science.gov (United States)

    Paluka, J. R.; Moore, S. F.

    1977-01-01

    Circuit incorporates three-terminal current limiter (78M24) to increase overall reliability and to eliminate transistor burnouts resulting from shorted interconnection lines and other overloads. Fact-acting light emitting diodes across the limiters show status of transistor output circuits.

  5. Delay Reduction in Optimized Reversible Multiplier Circuit

    Directory of Open Access Journals (Sweden)

    Mohammad Assarian

    2012-01-01

    Full Text Available In this study a novel reversible multiplier is presented. Reversible logic can play a significant role in computer domain. This logic can be applied in quantum computing, optical computing processing, DNA computing, and nanotechnology. One condition for reversibility of a computable model is that the number of input equate with the output. Reversible multiplier circuits are the circuits used frequently in computer system. For this reason, optimization in one reversible multiplier circuit can reduce its volume of hardware on one hand and increases the speed in a reversible system on the other hand. One of the important parameters that optimize a reversible circuit is reduction of delays in performance of the circuit. This paper investigates the performance characteristics of the gates, the circuits and methods of optimizing the performance of reversible multiplier circuits. Results showed that reduction of the reversible circuit layers has lead to improved performance due to the reduction of the propagation delay between input and output period. All the designs are in the nanometric scales.

  6. A Better Way to Drive "RLC" Circuits

    Science.gov (United States)

    Aguilar, Horacio Munguia

    2009-01-01

    An electronic circuit for controlling "RLC" experiments is shown. This arrangement does not employ a function generator, which makes it more suitable when a wide range of "R," "L" and "C" values is required and a relatively high current is involved. This circuit can be used for driven and undriven DC…

  7. Worst Asymmetrical Short-Circuit Current

    DEFF Research Database (Denmark)

    Arana Aristi, Iván; Holmstrøm, O; Grastrup, L

    2010-01-01

    In a typical power plant, the production scenario and the short-circuit time were found for the worst asymmetrical short-circuit current. Then, a sensitivity analysis on the missing generator values was realized in order to minimize the uncertainty of the results. Afterward the worst asymmetrical...

  8. Sustainability issues in circuit board recycling

    DEFF Research Database (Denmark)

    Legarth, Jens Brøbech; Alting, Leo; Baldo, Gian Luca

    1995-01-01

    The resource recovery and environmental impact issues of printed circuit board recycling by secondary copper smelters are discussed. Guidelines concerning material selection for circuit board manufacture and concerning the recycling processes are given to enhance recovery efficiency and to lower...... the impacts on the external environment from recycling...

  9. CMOS circuits for analog signal processing

    NARCIS (Netherlands)

    Wallinga, Hans

    1988-01-01

    Design choices in CMOS analog signal processing circuits are presented. Special attention is focussed on continuous-time filter technologies. The basics of MOSFET-C continuous-time filters and CMOS Square Law Circuits are explained at the hand of a graphical MOST characteristics representation.

  10. RF Circuit Design in Nanometer CMOS

    NARCIS (Netherlands)

    Nauta, Bram

    2007-01-01

    With CMOS technology entering the nanometer regime, the design of analog and RF circuits is complicated by low supply voltages, very non-linear (and nonquadratic) devices and large 1/f noise. At the same time, circuits are required to operate over increasingly wide bandwidths to implement modern mul

  11. Analysis of circuits including magnetic cores (MTRAC)

    Science.gov (United States)

    Hanzen, G. R.; Nitzan, D.; Herndon, J. R.

    1972-01-01

    Development of automated circuit analysis computer program to provide transient analysis of circuits with magnetic cores is discussed. Allowance is made for complications caused by nonlinearity of switching core model and magnetic coupling among loop currents. Computer program is conducted on Univac 1108 computer using FORTRAN IV.

  12. Design of drive circuit of laser diode

    Science.gov (United States)

    Ran, Yingying; Huang, Xuegong; Xu, Xiaobin

    2016-10-01

    Aiming at the difficult problem of high precision frequency stabilization of semiconductor laser diode, the laser frequency control is realized through the design of the semiconductor drive system. Above all, the relationship between the emission frequency and the temperature of LD is derived theoretically. Then the temperature corresponding to the stable frequency is obtained. According to the desired temperature stability of LD, temperature control system is designed, which is composed of a temperature setting circuit, temperature gathering circuit, the temperature display circuit, analog PID control circuit and a semiconductor refrigerator control circuit module. By sampling technology, voltage of platinum resistance is acquired, and the converted temperature is display on liquid crystal display. PID analog control circuit controls speed stability and precision of temperature control. The constant current source circuit is designed to provide the reference voltage by a voltage stabilizing chip, which is buffered by an operational amplifier. It is connected with the MOSFET to drive the semiconductor laser to provide stable current for the semiconductor laser. PCB circuit board was finished and the experimental was justified. The experimental results show that: the design of the temperature control system could achieve the goal of temperature monitoring. Meanwhile, temperature can be stabilized at 40°C +/- 0.1°C. The output voltage of the constant current source is 2 V. The current is 35 mA.

  13. IMPORTANT NOTICE: Cancellation of shuttle Circuit 3

    CERN Multimedia

    2013-01-01

    Circuit 3 of the CERN Shuttle Service (Point 5), which has served CMS since the start of LS1, will be cancelled with effect from Tuesday 16 April. This decision has been taken in consultation with CMS, as the circuit was seldom used.   In response to increasing demand for Circuit 1 - Meyrin and feedback from passengers, the two Circuit 3 journeys will be switched to Circuit 1 – Meyrin (see new timetable below): Mornings: Four journeys instead of three. Circuit 1 now starts at 8:10 (instead of 8:19 a.m.) and runs until 9:27 a.m. (instead of 9:16 a.m.). Lunchtimes: Five journeys in place between 12:10 p.m. and 1:47 p.m. Evenings: Circuit starts at 5:23 p.m. (instead of 5:03 p.m.) and ends at 6:20 p.m. at Building 33. Please note that the circuit will depart from Building 13 instead of Building 33.  

  14. Automatic design of digital synthetic gene circuits.

    Directory of Open Access Journals (Sweden)

    Mario A Marchisio

    2011-02-01

    Full Text Available De novo computational design of synthetic gene circuits that achieve well-defined target functions is a hard task. Existing, brute-force approaches run optimization algorithms on the structure and on the kinetic parameter values of the network. However, more direct rational methods for automatic circuit design are lacking. Focusing on digital synthetic gene circuits, we developed a methodology and a corresponding tool for in silico automatic design. For a given truth table that specifies a circuit's input-output relations, our algorithm generates and ranks several possible circuit schemes without the need for any optimization. Logic behavior is reproduced by the action of regulatory factors and chemicals on the promoters and on the ribosome binding sites of biological Boolean gates. Simulations of circuits with up to four inputs show a faithful and unequivocal truth table representation, even under parametric perturbations and stochastic noise. A comparison with already implemented circuits, in addition, reveals the potential for simpler designs with the same function. Therefore, we expect the method to help both in devising new circuits and in simplifying existing solutions.

  15. Automatic design of digital synthetic gene circuits.

    Science.gov (United States)

    Marchisio, Mario A; Stelling, Jörg

    2011-02-01

    De novo computational design of synthetic gene circuits that achieve well-defined target functions is a hard task. Existing, brute-force approaches run optimization algorithms on the structure and on the kinetic parameter values of the network. However, more direct rational methods for automatic circuit design are lacking. Focusing on digital synthetic gene circuits, we developed a methodology and a corresponding tool for in silico automatic design. For a given truth table that specifies a circuit's input-output relations, our algorithm generates and ranks several possible circuit schemes without the need for any optimization. Logic behavior is reproduced by the action of regulatory factors and chemicals on the promoters and on the ribosome binding sites of biological Boolean gates. Simulations of circuits with up to four inputs show a faithful and unequivocal truth table representation, even under parametric perturbations and stochastic noise. A comparison with already implemented circuits, in addition, reveals the potential for simpler designs with the same function. Therefore, we expect the method to help both in devising new circuits and in simplifying existing solutions.

  16. Mathematical modelling of fractional order circuits

    CERN Document Server

    Moreles, Miguel Angel

    2016-01-01

    In this work a classical derivation of fractional order circuits models is presented. Generalized constitutive equations in terms of fractional Riemann-Liouville derivatives are introduced in the Maxwell's equations. Next the Kirchhoff voltage law is applied in a RCL circuit configuration. A fractional differential equation model is obtained with Caputo derivatives. Thus standard initial conditions apply.

  17. F-Paris: integrated electronic circuits [Tender

    CERN Multimedia

    2003-01-01

    "Fourniture, montage et tests des circuits imprimes et modules multi composants pour le trajectographe central de CMS. Maximum de 12 000 circuits imprimes et modules multi-composants necessaires au trajectographe central de l'experience CMS aupres du Large Hadron Collider" (1 page).

  18. Apollo 14 mission circuit breaker anomaly

    Science.gov (United States)

    1971-01-01

    Continuity through the circuit breaker in the mechanically closed condition was prevented by a foreign substance on the contact surface onboard Apollo 14. It was concluded that this was the only failure of this type in over 3400 units that were flown, and since no circuit breaker is a single-point failure for crew safety or mission success, no corrective action was taken.

  19. Current Control Strategy of Chain Circuit STATCOM

    Institute of Scientific and Technical Information of China (English)

    WANG Xuan; FU Jian; TENG Letian; SUN Lijing; ZHAO Ruibin; WU Shouyuan; DENG Zhanfeng

    2012-01-01

    In order to study the current control strategy based on the chain circuit static synchronous compensator (STATCOM) dynamic model and the design control system with good stability and tracking accuracy, this paper applies the chain circuit STATCOM small signal AC model, and proposes the following assumptions:

  20. Synchronous transfer circuits for redundant systems

    Science.gov (United States)

    Nagano, S.

    1978-01-01

    Circuit arrangements for flip-flops, counters, and clock drivers in redundant systems ensure that control is synchronously transferred to surviving components when failure occurs. In addition to original application to spacecraft systems, redundant circuits have terrestrial uses in power generators, solar-energy converters, computers, vehicle controllers, and other systems demanding high reliability.