WorldWideScience

Sample records for cellswithout including heat-labile

  1. Radiation-induced heat-labile sites that convert into DNA double-strand breaks

    Science.gov (United States)

    Rydberg, B.; Chatterjee, A. (Principal Investigator)

    2000-01-01

    The yield of DNA double-strand breaks (DSBs) in SV40 DNA irradiated in aqueous solution was found to increase by more than a factor of two as a result of postirradiation incubation of the DNA at 50 degrees C and pH 8.0 for 24 h. This is in agreement with data from studies performed at 37 degrees C that were published previously. Importantly, similar results were also obtained from irradiation of mammalian DNA in agarose plugs. These results suggest that heat-labile sites within locally multiply damaged sites are produced by radiation and are subsequently transformed into DSBs. Since incubation at 50 degrees C is typically employed for lysis of cells in commonly used pulsed-field gel assays for detection of DSBs in mammalian cells, the possibility that heat-labile sites are present in irradiated cells was also studied. An increase in the apparent number of DSBs as a function of lysis time at 50 degrees C was found with kinetics that was similar to that for irradiated DNA, although the magnitude of the increase was smaller. This suggests that heat-labile sites are also formed in the cell. If this is the case, a proportion of DSBs measured by the pulsed-field gel assays may occur during the lysis step and may not be present in the cell as breaks but as heat-labile sites. It is suggested that such sites consist mainly of heat-labile sugar lesions within locally multiply damaged sites. Comparing rejoining of DSBs measured with short and long lysis procedure indicates that the heat-labile sites are repaired with fast kinetics in comparison with repair of the bulk of DSBs.

  2. Expression of functional pentameric heat-labile enterotoxin B subunit of Escherichia coli in Saccharomyces cerevisiae.

    Science.gov (United States)

    Lim, Jung-Gu; Kim, Jung-Ae; Chung, Hea-Jong; Kim, Tae-Geum; Kim, Jung-Mi; Lee, Kyung-Ryul; Park, Seung-Moon; Yang, Moon-Sik; Kim, Dae-Hyuk

    2009-05-01

    Although the Escherichia coli heat-labile enterotoxin B subunit (LTB) has already been expressed in several different systems, including prokaryotic and eukaryotic organisms, studies regarding the synthesis of LTB into oligomeric structures of pentameric size in the budding yeast Saccharomyces cerevisiae have been limited. Therefore, this study used a functional signal peptide of the amylase 1A protein from rice to direct the yeast-expressed LTB towards the endoplasmic reticulum to oligomerize with the expected pentameric size. The expression and assembly of the recombinant LTB were confirmed in both the cell-free extract and culture media of the recombinant strain using a Western blot analysis. The binding of the LTB pentamers to intestinal epithelial cell membrane glycolipid receptors was further verified using a GM1-ganglioside enzyme-linked immunosorbent assay (GM1-ELISA). On the basis of the GM1-ELISA results, pentameric LTB proteins comprised approximately 0.5-2.0% of the total soluble proteins, and the maximum quantity of secreted LTB was estimated to be 3 mg/l after a 3-day cultivation period. Consequently, the synthesis of LTB monomers and their assembly into biologically active oligomers in a recombinant S. cerevisiae strain demonstrated the feasibility of using a GRAS microorganism-based adjuvant, as well as the development of carriers against mucosal disease. PMID:19494699

  3. LACTOSE BINDING TO HEAT-LABILE ENTEROTOXIN REVEALED BY X-RAY CRYSTALLOGRAPHY

    NARCIS (Netherlands)

    SIXMA, TK; PRONK, SE; KALK, KH; VANZANTEN, BAM; HOL, WGJ

    1992-01-01

    RECOGNITION of the oligosaccharide portion of ganglioside G(M1) in membranes of target cells by the heat-labile enterotoxin from Escherichia coli is the crucial first step in its pathogenesis, as it is for the closely related cholera toxin 1-3. These toxins have five B subunits, which are essential

  4. Hereditary heat-labile hexosaminidase B: its implication for recognizing Tay-Sachs genotypes.

    OpenAIRE

    Navon, R; Nutman, J; Kopel, R; Gaber, L.; Gadoth, N; Goldman, B; Nitzan, M

    1981-01-01

    Two pairs of alleles, at the two loci of hexosaminidase (HEX), were found to segregate in an Arab inbred family: the normal and the mutant Tay-Sachs (TSD) alleles of HEX A, and the normal and a mutant allele of HEX B. Since the mutant HEX B is heat labile, no reliable identification of TSD genotypes can be obtained in its presence, as long as the proportions of HEX A and B are estimated by the routinely used heat-inactivation method. The genotypes may be correctly identified in such cases by ...

  5. Fusion of Escherichia coli heat-stable enterotoxin and heat-labile enterotoxin B subunit

    International Nuclear Information System (INIS)

    The 3' terminus of the DNA coding for the extracellular Escherichia coli heat-stable enterotoxin (ST) devoid of transcription and translation stop signals was fused to the 5' terminus of the DNA coding for the periplasmic B subunit of the heat-labile enterotoxin (LT/sub B/) deleted of ribosomal binding sites and leader peptide. By RNA-DNA hybridization analysis, it was shown that the fused DNA was transcribed in vivo into an RNA species in close agreement with the expected molecular weight inferred from the nucleotide sequence. The translation products of the fused DNA resulted in a hybrid molecule recognized in Western blots (immunoblots) with antibodies directed against the heat-labile moiety. Anti-LT/sub B/ antibodies coupled to a solid support bound ST and LT/sub B/ simultaneously when incubated with ST-LT/sub B/ cellular extracts. By [35S] cysteine pulse-chase experiments, it was shown that the fused ST-LT/sub B/ polypeptide was converted from a precursor with an equivalent electrophoretic mobility of 20,800 daltons to an approximately 18,500-dalton species, which accumulated within the cell. The data suggest that wild-type ST undergoes at least two processing steps during its export to the culture supernatant. Blocking the natural carboxy terminus of ST inhibited the second proteolytic step and extracellular delivery of the hybrid molecule

  6. Repair of radiation-induced heat-labile sites is independent of DNA-PKcs, XRCC1 or PARP

    Energy Technology Data Exchange (ETDEWEB)

    Stenerl& #246; w, Bo; Karlsson, Karin H.; Radulescu, Irina; Rydberg, Bjorn; Stenerlow, Bo

    2008-04-29

    Ionizing radiation induces a variety of different DNA lesions: in addition to the most critical DNA damage, the DSB, numerous base alterations, SSBs and other modifications of the DNA double-helix are formed. When several non-DSB lesions are clustered within a short distance along DNA, or close to a DSB, they may interfere with the repair of DSBs and affect the measurement of DSB induction and repair. We have previously shown that a substantial fraction of DSBs measured by pulsed-field gel electrophoresis (PFGE) are in fact due to heat-labile sites (HLS) within clustered lesions, thus reflecting an artifact of preparation of genomic DNA at elevated temperature. To further characterize the influence of HLS on DSB induction and repair, four human cell lines (GM5758, GM7166, M059K, U-1810) with apparently normal DSB rejoining were tested for bi-phasic rejoining after gamma irradiation. When heat-released DSBs were excluded from the measurements the fraction of fast rejoining decreased to less than 50% of the total. However, neither the half-times of the fast (t{sub 1/2} = 7-8 min) or slow (t{sub 1/2} = 2.5 h) DSB rejoining were changed significantly. At t=0 the heat-released DSBs accounted for almost 40% of the DSBs, corresponding to 10 extra DSB/cell/Gy in the initial DSB yield. These heat-released DSBs were repaired within 60-90 min in all tested cells, including M059K cells treated with wortmannin or DNA-PKcs defect M059J cells. Furthermore, cells lacking XRCC1 or Poly(ADP-ribose) polymerase-1 (PARP-1) rejoined both total DSBs and heat-released DSBs similar to normal cells. In summary, the presence of heat-labile sites have a substantial impact on DSB induction yields and DSB rejoining rates measured by pulsed-field gel electrophoresis, and HLS repair is independent of DNA-PKcs, XRCC1 and PARP.

  7. Hereditary heat-labile hexosaminidase B: its implication for recognizing Tay-Sachs genotypes.

    Science.gov (United States)

    Navon, R; Nutman, J; Kopel, R; Gaber, L; Gadoth, N; Goldman, B; Nitzan, M

    1981-11-01

    Two pairs of alleles, at the two loci of hexosaminidase (HEX), were found to segregate in an Arab inbred family: the normal and the mutant Tay-Sachs (TSD) alleles of HEX A, and the normal and a mutant allele of HEX B. Since the mutant HEX B is heat labile, no reliable identification of TSD genotypes can be obtained in its presence, as long as the proportions of HEX A and B are estimated by the routinely used heat-inactivation method. The genotypes may be correctly identified in such cases by separation of the two isoenzymes on ion-exchange chromatography, estimating their individual activities, and calculating the ratio between them. Of the nine genotype combinations possible with these two pairs of alleles, five have been identified in the reported family by this procedure. PMID:6459736

  8. Heat-labile enterotoxigenic Escherichia coli and intestinal protozoa in asymptomatic travellers.

    Science.gov (United States)

    Echeverria, P; Cross, J H

    1977-12-01

    Thirty-two asymptomatic travellers who had recently journeyed in the Near, Middle, and Far East and had experienced a high incidence of diarrhoeal disease were screened for heat-labile enterotoxigenic Escherichia coli (ent+ E. coli) and other bacterial and parasitic pathogens. Six percent were colonized with ent+ E. coli and while other bacterial pathogens were not found, the intestinal protozoa Giardia lamblia (13%), Entamoeba histolytica (6%), Entamoeba coli (6%), Endolimax nana (6%), and Entamoeba hartmanni (3%) were detected in the stools. Ent+ E. coli, G. lamblia and E. histolytica should be considered in the differential diagnosis of gastrointestinal disease in travellers returning from the Orient. Furthermore, these travellers may be a potential source for the introduction of ent+ E. coli into communities where such organisms are relatively rare. PMID:351820

  9. CRYSTAL-STRUCTURE OF A CHOLERA TOXIN-RELATED HEAT-LABILE ENTEROTOXIN FROM ESCHERICHIA-COLI

    NARCIS (Netherlands)

    SIXMA, TK; PRONK, SE; KALK, KH; WARTNA, ES; VANZANTEN, BAM; WITHOLT, B; HOL, WGJ

    1991-01-01

    Examination of the structure of Escherichia coli heat-labile enterotoxin in the AB5 complex at a resolution of 2.3 angstrom reveals that the doughnut-shaped B pentamer binds the enzymatic A subunit using a hairpin of the A2 fragment, through a highly charged central pore. Putative ganglioside G(M1-)

  10. Expression of E. coli heat-labile enterotoxin B subunit in transgenic tobacco plants

    Institute of Scientific and Technical Information of China (English)

    LIU Hong-li; ZHANG Zheng; LI Wen-sheng; ZHENG Jing; KONG Ling-hong; WANG Yi-li; SI Lü-sheng

    2005-01-01

    Objective: To construct plant transformation vector containing Escherichia coli heat-labile enterotoxin B subunit (LT-B) gene and generate LT-B transgenic tobacco plants. Methods: The LT-B coding sequence was amplified from pMMB68 by PCR, subcloned into middle vector pUCmT and binary vector pBI121 to obtain plant expression vector pBI-LTB, in which LT-B expression was controlled under the Cauliflower mosaic virus (CaMV) 35S promoter. The tobacco plants (Nicotiana tobacum L. Cuttivar Xanthi) were transformed by co-cultivating leaf discs method via Agrobacterium tumefaciens LBA4404 harboring the plant expression vector. The regenerated transgenic tobacco plants were selected by kanamycin and confirmed by PCR, Southern blot, Western blot and ELISA. Results: LT-B gene integrated in the tobacco genomic DNA and were expressed in 9 strains of transgenic tobacco plants. The yield was varied from 3.36-10.56 ng/mg total soluble tobacco leaf protein. Conclusion: The plant binary expression vector pBILTB was constructed successfully, and transgenic LT-B tobacco plants was generated, and confirmed by Southern blot. The protein LT-B expressed by engineered plants was identified by Western blot analysis and had the expected molecular weight of LT-B pentamer protein. This result is an important step close to developing an edible vaccine and supplying a mucasal immunoajuvant, which will contribute to the prevention of mucosa-route evading pathogen.

  11. Moist-heat sterilization and the chemical stability of heat-labile parenteral solutions.

    Science.gov (United States)

    Li, L C; Parasrampuria, J; Bommireddi, A; Pec, E; Dudleston, A; Mayoral, J

    1998-01-01

    The impact of moist-heat sterilization (autoclaving) on the chemical stability of parenteral solutions was examined using two heat-labile products, clindamycin phosphate and succinylcholine chloride injections, as examples. A nonisothermal kinetic model was used to predict the extent of product degradation during autoclaving. The predicted results were found to be in close agreement with the experimental data. For the same peak temperature, a greater loss of product was shown by using a cycle with a higher F0. On the other hand, a higher peak-temperature cycle resulted in less product degradation for the same F0 value. The benefit of a high-temperature cycle was further illustrated by the fact that less chemical degradation for both products was produced by a 122 degrees C cycle with an F0 of 11 as compared to that which occurred during a 116.5 degrees C cycle with an F0 of 8. Although clindamycin phosphate was found to be highly unstable during a conventional autoclaving process, predicted data indicate that a UHT (Ultra-High Temperature) process may be used to sterilize this product with acceptable degradation. PMID:15605602

  12. Mutants of Escherichia coli heat-labile enterotoxin and cholera toxin as mucosal adjuvants

    Institute of Scientific and Technical Information of China (English)

    FENG Qiang; CAI Shaoxi; ZOU Quanming

    2003-01-01

    Mucosal vaccination has been getting more and more recognition because of its compliance and low risk of spreading infectious disease by contaminated syringes used in subcutaneous immunization. However, most vaccines are unable to induce immune responses when given mucosally, and require the use of strong adjuvant for effective delivery systems. Heat-labile enterotoxin (LT) and Cholera toxin(CT) are powerful mucosal adjuvants when co-administered with soluble antigens. But high toxicity hampers their use in humans. Thanks to the fine knowledge of the structure-function relationship of LT and CT, many nontoxic or low toxic mutants have been generated, part of them retain high adjuvanticity of mucosal immunization. Among these mutants, LTS63K, LTA72R, LTR192G and CTE29H, CTE112K have been widely investigated. LTS63K and CTE112K are fully non toxic, whereas LTA72R and CTE29H are low toxic, and LTR192G is nontoxic in vitro(it remains the same toxicity as wild type LT in vivo). These mutants are extremely active as mucosal adjuvants when co-administrated with a variety of antigens in different animal models. They will be investigated more widely and deeply in the future. Some of them will be tested soon in human bodies.

  13. Evaluation of a ganglioside immunosorbent assay for detection of Escherichia coli heat-labile enterotoxin.

    Science.gov (United States)

    Bäck, E; Svennerholm, A M; Holmgren, J; Möllby, R

    1979-12-01

    The GM1 ganglioside enzyme-linked immunosorbent assay (GM1-ELISA), an immunological method for detection of Escherichia coli heat-labile enterotoxin (LT), was quantitatively and qualitatively compared with the conventional adrenal cell test for the identification of LT-producing strains. A micromodification model of the assay was developed. Enterotoxin preparations from 120 E. coli isolates from individuals with diarrhea, which had been previously shown to be enterotoxigenic by the adrenal cell test, and from 44 control strains of E. coli were compared in parallel by the two methods. Quantitatively the covariation of the enterotoxin titers was highly significant (RS = 0.98, P less than 0.001), the GM1-ELISA being somewhat more sensitive than the adrenal cell test. The methodological error was less than 5% in both tests. Qualitatively the overall agreement for positive and negative reactions for the two methods was 89%. The GM1-ELISA is practical for routine use in the diagnosis of enterotoxigenic E. coli, especially in laboratories without facilities for cell culture.

  14. Value of passive immune hemolysis for detection of heat-labile enterotoxin produced by enterotoxigenic Escherichia coli.

    OpenAIRE

    Tsukamoto, T; Kinoshita, Y; Taga, S; Takeda, Y; Miwatani, T

    1980-01-01

    The method of passive immune hemolysis of Evans and Evans (Infect. Immun. 16:604-609, 1977) for detection of heat-labile enterotoxin produced by enterotoxigenic Escherichia coli was modified. A total of 373 strains of E. coli were tested by this method using materials obtained by treating the cells with polymyxin B and rabbit antiserum against cholera enterotoxin, purified by affinity gel column coupled with purified cholera enterotoxin, in N-hydroxyethylpiperazine-N'-2-ethanesulfonic acid bu...

  15. Parenteral adjuvant effects of an enterotoxigenic Escherichia coli (ETEC natural heat-labile toxin variant

    Directory of Open Access Journals (Sweden)

    Catarina Joelma Magalhães Braga

    2014-01-01

    Full Text Available Native type I heat-labile toxins (LTs produced by enterotoxigenic Escherichia coli (ETEC strains exert strong adjuvant effects on both antibody and T cell responses to soluble and particulate antigens following co-administration via mucosal routes. However, inherent enterotoxicity and neurotoxicity (following intranasal delivery had reduced the interest in the use of these toxins as mucosal adjuvants. LTs can also behave as powerful and safe adjuvants following delivery via parenteral routes, particularly for activation of cytotoxic lymphocytes. In the present study, we evaluated the adjuvant effects of a new natural LT polymorphic form (LT2, after delivery via intradermal (i.d. and subcutaneous (s.c. routes, with regard to both antibody and T cell responses. A recombinant HIV-1 p24 protein was employed as a model antigen for determination of antigen-specific immune responses while the reference LT (LT1, produced by the ETEC H10407 strain, and a non-toxigenic LT form (LTK63 were employed as previously characterized LT types. LT-treated mice submitted to a four dose-base immunization regimen elicited similar p24-specific serum IgG responses and CD4+ T cell activation. Nonetheless, mice immunised with LT1 or LT2 induced higher numbers of antigen-specific CD8+ T cells and in vivo cytotoxic responses compared to mice immunised with the non-toxic LT derivative. These effects were correlated with stronger activation of local dendritic cell populations. In addition, mice immunized with LT1 and LT2, but not with LTK63, via s.c. or i.d. routes developed local inflammatory reactions. Altogether, the present results confirmed that the two most prevalent natural polymorphic LT variants (LT1 or LT2 display similar and strong adjuvant effects for subunit vaccines administered via i.d. or s.c. routes.

  16. OBTAINING OF MONOCLONAL ANTIBODIES AGAINST CHOLERA TOXIN AND HEAT LABILE ENTEROTOXIN OF E. coli FOR DEVELOPMENT OF THE TOXINS DIPLEX ANALYSIS IN ENVIRONMENTAL SPECIMENS

    Directory of Open Access Journals (Sweden)

    Eu. V. Grishin

    2013-08-01

    Full Text Available The present study focuses on development of monoclonal antibodies (MAbs which specifically interact with cholera toxin or heat labile enterotoxin of E. coli. Such monoclonal antibodies MAbs are possessed of ability to identify cholera toxin or heat labile enterotoxin in different immunochemical assays. We obtained hybridoma clones which produced monoclonal antibodies of IgG isotypes to cholera toxin and heat labile enterotoxin. On application of the method of serial dilutions we selected the clones which produced monoclonal antibodies with specific activity against only one of the toxins. We found the 16 pairs of monoclonal antibodies to cholera toxin and 28 ones to heat labile enterotoxin. By means of these monoclonal antibodies it was possible to realize the quantitative analysis of theses toxins in sandwich immunoassay ELISA and diplex sandwich xMAP-assay. The limits of detection of cholera toxin and heat labile enterotoxin in ELISA in control buffer were 0.2 and 0.4 ng/ml, respectively, and in xMAP assay — 0.01 and 0.08 ng/ml, respectively. In probes of cow milk, meat soup, pond water and nasopharyngeal washes cholera toxin was detected in the both assays with the same limits of detections, but heat labile enterotoxin limits of detections were above the ones in control buffers.

  17. X-RAY STUDIES REVEAL LANTHANIDE BINDING-SITES AT THE A/B5 INTERFACE OF ESCHERICHIA-COLI HEAT LABILE ENTEROTOXIN

    NARCIS (Netherlands)

    SIXMA, TK; VANSCHELTINGA, ACT; KALK, KH; WARTNA, ES; HOL, WGJ

    1992-01-01

    The crystal structure determination of heat labile enterotoxin (LT) bound to two different lanthanide ions, erbium and samarium, revealed two distinct ion binding sites in the interface of the A subunit and the B pentamer of the toxin. One of the interface sites is conserved in the very similar chol

  18. Protein engineering studies of A-chain loop 47-56 of Escherichia coli heat-labile enterotoxin point to a prominent role of this loop for cytotoxicity

    NARCIS (Netherlands)

    Feil, IK; Reddy, R; deHaan, L; Merritt, EA; vandenAkker, F; Storm, DR; Hol, WGJ

    1996-01-01

    Heat-labile enterotoxin (LT), produced by enterotoxigenic Escherichia coli, is a close relative of cholera toxin (CT), These two toxins share approximately 80% sequence identity, and consists of one 240-residue A chain and five 103-residue B subunits. The B pentamer is responsible for G(M1) receptor

  19. Intranuclear delivery of an antiviral peptide mediated by the B subunit of Escherichia coli heat-labile enterotoxin

    Science.gov (United States)

    Loregian, Arianna; Papini, Emanuele; Satin, Barbara; Marsden, Howard S.; Hirst, Timothy R.; Palù, Giorgio

    1999-01-01

    We report an intracellular peptide delivery system capable of targeting specific cellular compartments. In the model system we constructed a chimeric protein consisting of the nontoxic B subunit of Escherichia coli heat-labile enterotoxin (EtxB) fused to a 27-mer peptide derived from the DNA polymerase of herpes simplex virus 1. Viral DNA synthesis takes places in the nucleus and requires the interaction with an accessory factor, UL42, encoded by the virus. The peptide, designated Pol, is able to dissociate this interaction. The chimeric protein, EtxB-Pol, retained the functional properties of both EtxB and peptide components and was shown to inhibit viral DNA polymerase activity in vitro via disruption of the polymerase-UL42 complex. When added to virally infected cells, EtxB-Pol had no effect on adenovirus replication but specifically interfered with herpes simplex virus 1 replication. Further studies showed that the antiviral peptide localized in the nucleus, whereas the EtxB component remained associated with vesicular compartments. The results indicate that the chimeric protein entered through endosomal acidic compartments and that the Pol peptide was cleaved from the chimeric protein before being translocated into the nucleus. The system we describe is suitable for delivery of peptides that specifically disrupt protein–protein interactions and may be developed to target specific cellular compartments. PMID:10220447

  20. The suppressive activities of six sources of medicinal ferns known as gusuibu on heat-labile enterotoxin-induced diarrhea.

    Science.gov (United States)

    Chang, Hung-Chi; Chen, Jaw-Chyun; Yang, Jiun-Long; Tsay, Hsin-Sheng; Hsiang, Chien-Yun; Ho, Tin-Yun

    2014-02-18

    Diarrheal disease is one of the most important worldwide health problems. Enterotoxigenic Escherichia coli (ETEC) is the most frequently isolated enteropathogen in diarrheal diseases. In developing countries, a very large number of people, especially children, suffer from diarrhea. To combat this problem, World Health Organization has constituted the Diarrhea Diseases Control Program which guides studies on traditional medicinal practices and preventive measures. Gusuibu, a traditional folk medicine, has been claimed to heal certain types of diarrhea. However, so far no scientific study has been carried out on the anti-diarrheal mechanism of Gusiubu. The present study was performed to examine the suppressive activities of ethanol extracts of six sources of folk medicinal ferns used as Gusuibu on heat-labile enterotoxin (LT)-induced diarrhea. Inhibitory effects of six sources were evaluated on the ETEC LT subunit B (LTB) and monosialotetrahexosylganglioside (GMI) interaction by GM1-enzyme linked immunosorbent assay and patent mouse gut assay. Our results indicated that Drynaria fortunei had no anti-diarrheal effect, while, among the remaining five folk medicinal ferns, four belonging to family Davalliaceae had significant abilities on both the blocking of LTB and GM1 interaction and the inhibition of LT-induced diarrhea. In conclusion, these findings suggested the potential application of Gusuibu as an anti-diarrheal remedy.

  1. Transient facial nerve paralysis (Bell's palsy following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.

    Directory of Open Access Journals (Sweden)

    David J M Lewis

    Full Text Available BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT adjuvant. The individual component(s responsible for paralysis were not identified, and the vaccine was withdrawn. METHODOLOGY/PRINCIPAL FINDINGS: Subjects participating in two contemporaneous non-randomized Phase 1 clinical trials of nasal subunit vaccines against Human Immunodeficiency Virus and tuberculosis, both of which employed an enzymatically inactive non-toxic mutant LT adjuvant (LTK63, underwent active follow-up for adverse events using diary-cards and clinical examination. Two healthy subjects experienced transient peripheral facial nerve palsies 44 and 60 days after passive nasal instillation of LTK63, possibly a result of retrograde axonal transport after neuronal ganglioside binding or an inflammatory immune response, but without exaggerated immune responses to LTK63. CONCLUSIONS/SIGNIFICANCE: While the unique anatomical predisposition of the facial nerve to compression suggests nasal delivery of neuronal-binding LT-derived adjuvants is inadvisable, their continued investigation as topical or mucosal adjuvants and antigens appears warranted on the basis of longstanding safety via oral, percutaneous, and other mucosal routes.

  2. Antibody against recombinant heat labile enterotoxin B subunit (rLTB could block LT binding to ganglioside M1 receptor

    Directory of Open Access Journals (Sweden)

    SM Moazzeni

    2010-12-01

    Full Text Available Objectives: Enterotoxigenic Escherichia coli (ETEC is one of the most common agents of diarrhea among other bacterial agents. Designing and producing vaccine against these bacteria is one of the major purposes of World Health Organization (WHO. Due to presence of diverse clones of ETEC strains in the world, the use of global vaccines for ETEC infection is controversial. B subunit of heat labile toxin (LTB was introduced as a vaccine candidate molecule by several investigators. The expression of LTB gene isolated from a local bacterial strain and investigation of its immunological property was the objective of this study."nMaterials and Methods: LTB gene was isolated from a local isolated ETEC, cloned and expressed using pET28a expression vector. For LTB gene expression, the three main expression parameters (IPTG concentration, time and temperature of induction were investigated. The recombinant protein was purified ( > 95% with Ni-NTA column using 6XHis-tag and used as an antigen in ELISA test."nResults: The immunological analyses showed production of high titer of specific antibody in immunized mice. Anti LTB Antibody could bind to whole toxin and neutralize the toxin through inhibition of its binding to the Ganglioside M1 receptor."nConclusion: The recombinant LTB protein is a highly immunogenic molecule. Considering the LTB role in ETEC pathogenesis, it can be taken into account as one of the most important components of vaccines against local ETEC.

  3. Parenteral Adjuvant Activities of Escherichia coli Heat-Labile Toxin and Its B Subunit for Immunization of Mice against Gastric Helicobacter pylori Infection

    OpenAIRE

    Weltzin, Richard; Guy, Bruno; Thomas, William D.; Giannasca, Paul J.; Monath, Thomas P.

    2000-01-01

    The heat-labile toxin (LT) of Escherichia coli is a potent mucosal adjuvant that has been used to induce protective immunity against Helicobacter felis and Helicobacter pylori infection in mice. We studied whether recombinant LT or its B subunit (LTB) has adjuvant activity in mice when delivered with H. pylori urease antigen via the parenteral route. Mice were immunized subcutaneously or intradermally with urease plus LT, recombinant LTB, or a combination of LT and LTB prior to intragastric c...

  4. Allele Variants of Enterotoxigenic Escherichia coli Heat-Labile Toxin Are Globally Transmitted and Associated with Colonization Factors

    KAUST Repository

    Joffré, Enrique

    2015-01-15

    Enterotoxigenic Escherichia coli (ETEC) is a significant cause of morbidity and mortality in the developing world. ETEC-mediated diarrhea is orchestrated by heat-labile toxin (LT) and heat-stable toxins (STp and STh), acting in concert with a repertoire of more than 25 colonization factors (CFs). LT, the major virulence factor, induces fluid secretion after delivery of a monomeric ADP-ribosylase (LTA) and its pentameric carrier B subunit (LTB). A study of ETEC isolates from humans in Brazil reported the existence of natural LT variants. In the present study, analysis of predicted amino acid sequences showed that the LT amino acid polymorphisms are associated with a geographically and temporally diverse set of 192 clinical ETEC strains and identified 12 novel LT variants. Twenty distinct LT amino acid variants were observed in the globally distributed strains, and phylogenetic analysis showed these to be associated with different CF profiles. Notably, the most prevalent LT1 allele variants were correlated with major ETEC lineages expressing CS1 + CS3 or CS2 + CS3, and the most prevalent LT2 allele variants were correlated with major ETEC lineages expressing CS5 + CS6 or CFA/I. LTB allele variants generally exhibited more-stringent amino acid sequence conservation (2 substitutions identified) than LTA allele variants (22 substitutions identified). The functional impact of LT1 and LT2 polymorphisms on virulence was investigated by measuring total-toxin production, secretion, and stability using GM1-enzyme-linked immunosorbent assays (GM1-ELISA) and in silico protein modeling. Our data show that LT2 strains produce 5-fold more toxin than LT1 strains (P < 0.001), which may suggest greater virulence potential for this genetic variant. Our data suggest that functionally distinct LT-CF variants with increased fitness have persisted during the evolution of ETEC and have spread globally.

  5. Evaluating the A-Subunit of the Heat-Labile Toxin (LT As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC.

    Directory of Open Access Journals (Sweden)

    Elizabeth B Norton

    Full Text Available Diarrheal illness contributes to malnutrition, stunted growth, impaired cognitive development, and high morbidity rates in children worldwide. Enterotoxigenic Escherichia coli (ETEC is a major contributor to this diarrheal disease burden. ETEC cause disease in the small intestine by means of colonization factors and by production of a heat-labile enterotoxin (LT and/or a small non-immunogenic heat-stable enterotoxin (ST. Overall, the majority of ETEC produce both ST and LT. LT induces secretion via an enzymatically active A-subunit (LT-A and a pentameric, cell-binding B-subunit (LT-B. The importance of anti-LT antibodies has been demonstrated in multiple clinical and epidemiological studies, and a number of potential ETEC vaccine candidates have included LT-B as an important immunogen. However, there is limited information about the potential contribution of LT-A to development of protective immunity. In the current study, we evaluate the immune response against the A-subunit of LT as well as the A-subunit's potential as a protective antigen when administered alone or in combination with the B-subunit of LT. We evaluated human sera from individuals challenged with a prototypic wild-type ETEC strain as well as sera from individuals living in an ETEC endemic area for the presence of anti-LT, anti-LT-A and anti-LT-B antibodies. In both cases, a significant number of individuals intentionally or endemically infected with ETEC developed antibodies against both LT subunits. In addition, animals immunized with the recombinant proteins developed robust antibody responses that were able to neutralize the enterotoxic and cytotoxic effects of native LT by blocking binding and entry into cells (anti-LT-B or the intracellular enzymatic activity of the toxin (anti-LT-A. Moreover, antibodies to both LT subunits acted synergistically to neutralize the holotoxin when combined. Taken together, these data support the inclusion of both LT-A and LT-B in prospective

  6. Treatment of PCR products with exonuclease I and heat-labile alkaline phosphatase improves the visibility of combined bisulfite restriction analysis

    International Nuclear Information System (INIS)

    Research highlights: → Incubating PCR products at a high temperature causes smears in gel electrophoresis. → Smears interfere with the interpretation of methylation analysis using COBRA. → Treatment with exonuclease I and heat-labile alkaline phosphatase eliminates smears. → The elimination of smears improves the visibility of COBRA. -- Abstract: DNA methylation plays a vital role in the regulation of gene expression. Abnormal promoter hypermethylation is an important mechanism of inactivating tumor suppressor genes in human cancers. Combined bisulfite restriction analysis (COBRA) is a widely used method for identifying the DNA methylation of specific CpG sites. Here, we report that exonuclease I and heat-labile alkaline phosphatase can be used for PCR purification for COBRA, improving the visibility of gel electrophoresis after restriction digestion. This improvement is observed when restriction digestion is performed at a high temperature, such as 60 oC or 65 oC, with BstUI and TaqI, respectively. This simple method can be applied instead of DNA purification using spin columns or phenol/chloroform extraction. It can also be applied to other situations when PCR products are digested by thermophile-derived restriction enzymes, such as PCR restriction fragment length polymorphism (RFLP) analysis.

  7. Treatment of PCR products with exonuclease I and heat-labile alkaline phosphatase improves the visibility of combined bisulfite restriction analysis

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Kousuke; Emoto, Noriko; Sunohara, Mitsuhiro; Kawakami, Masanori; Kage, Hidenori; Nagase, Takahide; Ohishi, Nobuya [Department of Respiratory Medicine, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Takai, Daiya, E-mail: dtakai-ind@umin.ac.jp [Department of Clinical Laboratory, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan)

    2010-08-27

    Research highlights: {yields} Incubating PCR products at a high temperature causes smears in gel electrophoresis. {yields} Smears interfere with the interpretation of methylation analysis using COBRA. {yields} Treatment with exonuclease I and heat-labile alkaline phosphatase eliminates smears. {yields} The elimination of smears improves the visibility of COBRA. -- Abstract: DNA methylation plays a vital role in the regulation of gene expression. Abnormal promoter hypermethylation is an important mechanism of inactivating tumor suppressor genes in human cancers. Combined bisulfite restriction analysis (COBRA) is a widely used method for identifying the DNA methylation of specific CpG sites. Here, we report that exonuclease I and heat-labile alkaline phosphatase can be used for PCR purification for COBRA, improving the visibility of gel electrophoresis after restriction digestion. This improvement is observed when restriction digestion is performed at a high temperature, such as 60 {sup o}C or 65 {sup o}C, with BstUI and TaqI, respectively. This simple method can be applied instead of DNA purification using spin columns or phenol/chloroform extraction. It can also be applied to other situations when PCR products are digested by thermophile-derived restriction enzymes, such as PCR restriction fragment length polymorphism (RFLP) analysis.

  8. Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.

    Science.gov (United States)

    Norton, Elizabeth B; Lawson, Louise B; Freytag, Lucy C; Clements, John D

    2011-04-01

    Despite the fact that the adjuvant properties of the heat-labile enterotoxins of Escherichia coli (LT) and Vibrio cholerae (CT) have been known for more than 20 years, there are no available oral vaccines containing these molecules as adjuvants, primarily because they are both very potent enterotoxins. A number of attempts with various degrees of success have been made to reduce or eliminate the enterotoxicity of LT and CT so they can safely be used as oral adjuvants or immunogens. In this report we characterize the structural, enzymatic, enterotoxic, and adjuvant properties of a novel mutant of LT, designated LT(R192G/L211A), or dmLT. dmLT was not sensitive to trypsin activation, had reduced enzymatic activity for induction of cyclic AMP in Caco-2 cells, and exhibited no enterotoxicity in the patent mouse assay. Importantly, dmLT retained the ability to function as an oral adjuvant for a coadministered antigen (tetanus toxoid) and to elicit anti-LT antibodies. In vitro and in vivo data suggest that the reduced enterotoxicity of this molecule compared to native LT or the single mutant, LT(R192G), is a consequence of increased sensitivity to proteolysis and rapid intracellular degradation in mammalian cells. In conclusion, dmLT is a safe and powerful detoxified enterotoxin with the potential to function as a mucosal adjuvant for coadministered antigens and to elicit anti-LT antibodies without undesirable side effects. PMID:21288994

  9. Single Chain Variable Fragments Produced in Escherichia coli against Heat-Labile and Heat-Stable Toxins from Enterotoxigenic E. coli.

    Directory of Open Access Journals (Sweden)

    Christiane Y Ozaki

    Full Text Available Diarrhea is a prevalent pathological condition frequently associated to the colonization of the small intestine by enterotoxigenic Escherichia coli (ETEC strains, known to be endemic in developing countries. These strains can produce two enterotoxins associated with the manifestation of clinical symptoms that can be used to detect these pathogens. Although several detection tests have been developed, minimally equipped laboratories are still in need of simple and cost-effective methods. With the aim to contribute to the development of such diagnostic approaches, we describe here two mouse hybridoma-derived single chain fragment variable (scFv that were produced in E. coli against enterotoxins of ETEC strains.Recombinant scFv were developed against ETEC heat-labile toxin (LT and heat-stable toxin (ST, from previously isolated hybridoma clones. This work reports their design, construction, molecular and functional characterization against LT and ST toxins. Both antibody fragments were able to recognize the cell-interacting toxins by immunofluorescence, the purified toxins by ELISA and also LT-, ST- and LT/ST-producing ETEC strains.The developed recombinant scFvs against LT and ST constitute promising starting point for simple and cost-effective ETEC diagnosis.

  10. Single Chain Variable Fragments Produced in Escherichia coli against Heat-Labile and Heat-Stable Toxins from Enterotoxigenic E. coli

    Science.gov (United States)

    Andrade, Fernanda B.; Nepomuceno, Roberto; Silva, Anderson; Munhoz, Danielle D.; Yamamoto, Bruno B.; Luz, Daniela; Abreu, Patrícia A. E.; Horton, Denise S. P. Q.; Elias, Waldir P.; Ramos, Oscar H. P.; Piazza, Roxane M. F.

    2015-01-01

    Background Diarrhea is a prevalent pathological condition frequently associated to the colonization of the small intestine by enterotoxigenic Escherichia coli (ETEC) strains, known to be endemic in developing countries. These strains can produce two enterotoxins associated with the manifestation of clinical symptoms that can be used to detect these pathogens. Although several detection tests have been developed, minimally equipped laboratories are still in need of simple and cost-effective methods. With the aim to contribute to the development of such diagnostic approaches, we describe here two mouse hybridoma-derived single chain fragment variable (scFv) that were produced in E. coli against enterotoxins of ETEC strains. Methods and Findings Recombinant scFv were developed against ETEC heat-labile toxin (LT) and heat-stable toxin (ST), from previously isolated hybridoma clones. This work reports their design, construction, molecular and functional characterization against LT and ST toxins. Both antibody fragments were able to recognize the cell-interacting toxins by immunofluorescence, the purified toxins by ELISA and also LT-, ST- and LT/ST-producing ETEC strains. Conclusion The developed recombinant scFvs against LT and ST constitute promising starting point for simple and cost-effective ETEC diagnosis. PMID:26154103

  11. Toxicity and immunogenicity of Enterotoxigenic Escherichia coli heat-labile and heat-stable toxoid fusion 3xSTa(A14Q-LT(S63K/R192G/L211A in a murine model.

    Directory of Open Access Journals (Sweden)

    Chengxian Zhang

    Full Text Available Diarrhea is the second leading cause of death to young children. Enterotoxigenic Escherichia coli (ETEC are the most common bacteria causing diarrhea. Adhesins and enterotoxins are the virulence determinants in ETEC diarrhea. Adhesins mediate bacterial attachment and colonization, and enterotoxins including heat-labile (LT and heat-stable type Ib toxin (STa disrupt fluid homeostasis in host cells that leads to fluid hyper-secretion and diarrhea. Thus, adhesins and enterotoxins have been primarily targeted in ETEC vaccine development. A recent study reported toxoid fusions with STa toxoid (STa(P13F fused at the N- or C-terminus, or inside the A subunit of LT(R192G elicited neutralizing antitoxin antibodies, and suggested application of toxoid fusions in ETEC vaccine development (Liu et al., Infect. Immun. 79:4002-4009, 2011. In this study, we generated a different STa toxoid (STa(A14Q and a triple-mutant LT toxoid (LT(S63K/R192G/L211A, tmLT, constructed a toxoid fusion (3xSTa(A14Q-tmLT that carried 3 copies of STa(A14Q for further facilitation of anti-STa immunogenicity, and assessed antigen safety and immunogenicity in a murine model to explore its potential for ETEC vaccine development. Mice immunized with this fusion antigen showed no adverse effects, and developed antitoxin antibodies particularly through the IP route. Anti-LT antibodies were detected and were shown neutralizing against CT in vitro. Anti-STa antibodies were also detected in the immunized mice, and serum from the IP immunized mice neutralized STa toxin in vitro. Data from this study indicated that toxoid fusion 3xSTa(A14Q-tmLT is safe and can induce neutralizing antitoxin antibodies, and provided helpful information for vaccine development against ETEC diarrhea.

  12. Toxicity and immunogenicity of Enterotoxigenic Escherichia coli heat-labile and heat-stable toxoid fusion 3xSTa(A14Q)-LT(S63K/R192G/L211A) in a murine model.

    Science.gov (United States)

    Zhang, Chengxian; Knudsen, David E; Liu, Mei; Robertson, Donald C; Zhang, Weiping

    2013-01-01

    Diarrhea is the second leading cause of death to young children. Enterotoxigenic Escherichia coli (ETEC) are the most common bacteria causing diarrhea. Adhesins and enterotoxins are the virulence determinants in ETEC diarrhea. Adhesins mediate bacterial attachment and colonization, and enterotoxins including heat-labile (LT) and heat-stable type Ib toxin (STa) disrupt fluid homeostasis in host cells that leads to fluid hyper-secretion and diarrhea. Thus, adhesins and enterotoxins have been primarily targeted in ETEC vaccine development. A recent study reported toxoid fusions with STa toxoid (STa(P13F)) fused at the N- or C-terminus, or inside the A subunit of LT(R192G) elicited neutralizing antitoxin antibodies, and suggested application of toxoid fusions in ETEC vaccine development (Liu et al., Infect. Immun. 79:4002-4009, 2011). In this study, we generated a different STa toxoid (STa(A14Q)) and a triple-mutant LT toxoid (LT(S63K/R192G/L211A), tmLT), constructed a toxoid fusion (3xSTa(A14Q)-tmLT) that carried 3 copies of STa(A14Q) for further facilitation of anti-STa immunogenicity, and assessed antigen safety and immunogenicity in a murine model to explore its potential for ETEC vaccine development. Mice immunized with this fusion antigen showed no adverse effects, and developed antitoxin antibodies particularly through the IP route. Anti-LT antibodies were detected and were shown neutralizing against CT in vitro. Anti-STa antibodies were also detected in the immunized mice, and serum from the IP immunized mice neutralized STa toxin in vitro. Data from this study indicated that toxoid fusion 3xSTa(A14Q)-tmLT is safe and can induce neutralizing antitoxin antibodies, and provided helpful information for vaccine development against ETEC diarrhea.

  13. Attenuated Salmonella Gallinarum secreting an Escherichia coli heat-labile enterotoxin B subunit protein as an adjuvant for oral vaccination against fowl typhoid.

    Science.gov (United States)

    Jeon, Byung Woo; Jawale, Chetan V; Kim, Seung Hwan; Lee, John Hwa

    2012-12-15

    In our previous study, we constructed a vaccine candidate (JOL916) for fowl typhoid (FT). A live adjuvant Salmonella Gallinarum (SG) strain was generated in the present study to facilitate efficacious oral vaccination with this vaccine. The Escherichia coli eltB gene secreting heat-labile enterotoxin B subunit (LTB) was cloned into an Asd(+) plasmid pJHL65. This was transformed into a Δlon ΔcpxR Δasd SG strain and the resulting strain was designated JOL1229. Secretion of LTB from JOL1229 was confirmed with an immunoblot assay. To determine the optimal dose of the strain, 50 six-week-old female chickens were divided into five groups (Groups A-E, n=10 per group) and orally inoculated with various doses of JOL1229 and JOL916. In Group B (consisting of four parts JOL916 and one part JOL1229), significant cell-mediated immune responses, plasma IgG levels and intestinal secretary IgA levels were induced after inoculation with both strains. On challenge with the wild-type strain, significant reductions in mortality were observed in the group. In addition, after inoculation the LTB strain was not recovered in feces samples, and resulted in no, or very mild, gross lesions in the liver and spleen. Both CD4(+) and CD8(+) T-cells were significantly increased in peripheral blood samples from the chickens immunized with the LTB strain. Expression of the interleukin-6 (IL-6) gene in splenocytes was induced in the chickens immunized with the LTB strain. These results suggest that oral immunization with the LTB-adjuvant strain, in particular with the four parts JOL916 and one part JOL1229 mixture, increased the immune response and provided efficient protection against FT in chickens.

  14. Alkaline pH Is a signal for optimal production and secretion of the heat labile toxin, LT in enterotoxigenic Escherichia coli (ETEC.

    Directory of Open Access Journals (Sweden)

    Lucia Gonzales

    Full Text Available Enterotoxigenic Escherichia coli (ETEC cause secretory diarrhea in children and travelers to endemic areas. ETEC spreads through the fecal-oral route. After ingestion, ETEC passes through the stomach and duodenum before it colonizes the lower part of the small intestine, exposing bacteria to a wide range of pH and environmental conditions. This study aimed to determine the impact of external pH and activity of the Cyclic AMP receptor protein (CRP on the regulation of production and secretion of heat labile (LT enterotoxin. ETEC strain E2863wt and its isogenic mutant E2863ΔCRP were grown in LBK media buffered to pH 5, 7 and 9. GM1 ELISA, cDNA and cAMP analyses were carried out on bacterial pellet and supernatant samples derived from 3 and 5 hours growth and from overnight cultures. We confirm that CRP is a repressor of LT transcription and production as has been shown before but we show for the first time that CRP is a positive regulator of LT secretion both in vitro and in vivo. LT secretion increased at neutral to alkaline pH compared to acidic pH 5 where secretion was completely inhibited. At pH 9 secretion of LT was optimal resulting in 600 percent increase of secreted LT compared to unbuffered LBK media. This effect was not due to membrane leakage since the bacteria were viable at pH 9. The results indicate that the transition to the alkaline duodenum and/or exposure to high pH close to the epithelium as well as activation of the global transcription factor CRP are signals that induce secretion of the LT toxin in ETEC.

  15. Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.

    Science.gov (United States)

    Liu, Lin; Ma, Yongping; Zhou, Huicong; Wu, Mingjun

    2016-01-01

    The nontoxic heat-labile toxin (LT) B subunit (LTB) was used as mucosal adjuvant experimentally. However, the mechanism of LTB adjuvant was still unclear. The LTB and enterovirus 71 (EV71) VP1 subunit (EVP1) were constructed in pET32 and expressed in E. coli BL21, respectively. The immunogenicity of purified EVP1 and the adjuvanticity of LTB were evaluated via intranasal immunization EVP1 plus LTB in Balb/c mice. In order to elucidate the proteome change triggered by the adjuvant of LTB, the proteomic profiles of LTB, EVP1, and LTB plus EVP1 were quantitatively analyzed by iTRAQ-LC-MS/MS (isobaric tags for relative and absolute quantitation; liquid chromatography-tandem mass spectrometry) in murine macrophage RAW264.7. The proteomic data were analyzed by bioinformatics and validated by western blot analysis. The predicted protein interactions were confirmed using LTB pull-down and the LTB processing pathway was validated by confocal microscopy. The results showed that LTB significantly boosted EVP1 specific systematic and mucosal antibodies. A total of 3666 differential proteins were identified in the three groups. Pathway enrichment of proteomic data predicted that LTB upregulated the specific and dominant MAPK (mitogen-activated protein kinase) signaling pathway and the protein processing in endoplasmic reticulum (PPER) pathway, whereas LTB or EVP1 did not significantly upregulate these two signaling pathways. Confocal microscopy and LTB pull-down assays confirmed that the LTB adjuvant was endocytosed and processed through endocytosis (ENS)-lysosomal-endoplasmic reticulum (ER) system. PMID:27618897

  16. Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.

    Science.gov (United States)

    Liu, Lin; Ma, Yongping; Zhou, Huicong; Wu, Mingjun

    2016-01-01

    The nontoxic heat-labile toxin (LT) B subunit (LTB) was used as mucosal adjuvant experimentally. However, the mechanism of LTB adjuvant was still unclear. The LTB and enterovirus 71 (EV71) VP1 subunit (EVP1) were constructed in pET32 and expressed in E. coli BL21, respectively. The immunogenicity of purified EVP1 and the adjuvanticity of LTB were evaluated via intranasal immunization EVP1 plus LTB in Balb/c mice. In order to elucidate the proteome change triggered by the adjuvant of LTB, the proteomic profiles of LTB, EVP1, and LTB plus EVP1 were quantitatively analyzed by iTRAQ-LC-MS/MS (isobaric tags for relative and absolute quantitation; liquid chromatography-tandem mass spectrometry) in murine macrophage RAW264.7. The proteomic data were analyzed by bioinformatics and validated by western blot analysis. The predicted protein interactions were confirmed using LTB pull-down and the LTB processing pathway was validated by confocal microscopy. The results showed that LTB significantly boosted EVP1 specific systematic and mucosal antibodies. A total of 3666 differential proteins were identified in the three groups. Pathway enrichment of proteomic data predicted that LTB upregulated the specific and dominant MAPK (mitogen-activated protein kinase) signaling pathway and the protein processing in endoplasmic reticulum (PPER) pathway, whereas LTB or EVP1 did not significantly upregulate these two signaling pathways. Confocal microscopy and LTB pull-down assays confirmed that the LTB adjuvant was endocytosed and processed through endocytosis (ENS)-lysosomal-endoplasmic reticulum (ER) system.

  17. Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

    Directory of Open Access Journals (Sweden)

    Yinglin eQi

    2015-03-01

    Full Text Available Rabies remains an important worldwide public health threat, so safe, effective and affordable vaccines are still being sought. Virus-like particle (VLP-based vaccines targeting various viral pathogens have been successfully produced, licensed and commercialized. Here, we designed and constructed two chimeric rabies virus-like particles (cRVLPs containing rabies virus (RABV glycoprotein (G, matrix (M protein, and membrane-anchored flagellin (EVLP-F or Escherichia coli heat-labile enterotoxin B subunit (EVLP-L as molecular adjuvants to enhance the immune response against rabies. The immunogenicity and potential of cRVLPs as novel rabies vaccine were evaluated by intramuscular vaccination in mouse and dog models. Mouse studies demonstrated that both EVLP-F and EVLP-L induced faster and larger virus-neutralizing antibodies (VNA responses and elicited greater numbers of CD4+ and CD8+ T cells secreting IFN-γ or IL-4 compared with a standard rabies VLP (sRVLP containing only G and M. Moreover, cRVLPs recruited and/or activated more B cells and dendritic cells in inguinal lymph nodes. EVLP-F induced a strong, specific IgG2a response but not an IgG1 response, suggesting the activation of Th1 class immunity; in contrast, Th2 class immunity was observed with EVLP-L. The significantly enhanced humoral and cellular immune responses induced by cRVLPs provided complete protection against lethal challenge with RABV. Most importantly, dogs vaccinated with EVLP-F or EVLP-L exhibited increased VNA titers in sera and enhanced IFN-γ and IL-4 secretion from peripheral blood mononuclear cells. Taken together, these results illustrate that when incorporated into sRVLP, membrane-anchored flagellin and LTB possess strong adjuvant activity. EVLP-F and EVLP-L induce significantly enhanced RABV-specific humoral and cellular immune responses in both mouse and dog. Therefore, these cRVLPs may be developed as safe and more efficacious rabies vaccine candidate for animals.

  18. Design and characterization of a chimeric multiepitope construct containing CfaB, heat-stable toxoid, CssA, CssB, and heat-labile toxin subunit B of enterotoxigenic Escherichia coli: a bioinformatic approach.

    Science.gov (United States)

    Zeinalzadeh, Narges; Salmanian, Ali Hatef; Ahangari, Ghasem; Sadeghi, Mahdi; Amani, Jafar; Bathaie, S Zahra; Jafari, Mahyat

    2014-01-01

    Enterotoxigenic Escherichia coli (ETEC) strains are the most common cause of bacterial diarrhea in children in developing countries and travelers to these areas. Enterotoxins and colonization factors (CFs) are two key virulence factors in ETEC pathogenesis, and the heterogeneity of the CFs is the bottleneck in reaching an effective vaccine. In this study, a candidate subunit vaccine, which is composed of CfaB, CssA and CssB, structural subunits of colonization factor antigen I and CS6 CFs, labile toxin subunit B, and the binding subunit of heat-labile and heat-stable toxoid, was designed to provide broad-spectrum protection against ETEC. The different features of chimeric gene, its mRNA stability, and chimeric protein properties were analyzed by using bioinformatic tools. The optimized chimeric gene was chemically synthesized and expressed successfully in a prokaryotic host. The purified protein was used for assessment of bioinformatic data by experimental methods.

  19. Structure–activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding

    International Nuclear Information System (INIS)

    Structural data for the S74D variant of the pentameric B subunit of type II heat-labile enterotoxin of Escherichia coli reveal a smaller pore opening that may explain its reduced Toll-like receptor binding affinity compared to that of the wild type enterotoxin. The explanation for the enhanced Toll-like receptor binding affinity of the S74A variant is more complex than simply being attributed to the pore opening. The pentameric B subunit of the type II heat-labile enterotoxin of Escherichia coli (LT-IIb-B5) is a potent signaling molecule capable of modulating innate immune responses. It has previously been shown that LT-IIb-B5, but not the LT-IIb-B5 Ser74Asp variant [LT-IIb-B5(S74D)], activates Toll-like receptor (TLR2) signaling in macrophages. Consistent with this, the LT-IIb-B5(S74D) variant failed to bind TLR2, in contrast to LT-IIb-B5 and the LT-IIb-B5 Thr13Ile [LT-IIb-B5(T13I)] and LT-IIb-B5 Ser74Ala [LT-IIb-B5(S74A)] variants, which displayed the highest binding activity to TLR2. Crystal structures of the Ser74Asp, Ser74Ala and Thr13Ile variants of LT-IIb-B5 have been determined to 1.90, 1.40 and 1.90 Å resolution, respectively. The structural data for the Ser74Asp variant reveal that the carboxylate side chain points into the pore, thereby reducing the pore size compared with that of the wild-type or the Ser74Ala variant B pentamer. On the basis of these crystallographic data, the reduced TLR2-binding affinity of the LT-IIb-B5(S74D) variant may be the result of the pore of the pentamer being closed. On the other hand, the explanation for the enhanced TLR2-binding activity of the LT-IIb-B5(S74A) variant is more complex as its activity is greater than that of the wild-type B pentamer, which also has an open pore as the Ser74 side chain points away from the pore opening. Data for the LT-IIb-B5(T13I) variant show that four of the five variant side chains point to the outside surface of the pentamer and one residue points inside. These data are consistent with

  20. Characterization of heat-labile toxin-subunit B from Escherichia coli by liquid chromatography-electrospray ionization-mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

    Science.gov (United States)

    Sospedra, I; De Simone, C; Soriano, J M; Mañes, J; Ferranti, P; Ritieni, A

    2012-11-01

    The possibilities of characterizing the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) by liquid chromatography electrospray mass spectrometry (LC/ESI-MS) and matrix-assisted laser desorption with time-of-flight mass spectrometry (MALDI-TOF-MS) were investigated. The B subunit from recombinant E. coli (expression in Pichia pastoris) can be detected by LC/ESI-MS expressed in P. pastoris and the charge envelope signals can be observed; LC/ESI-MS and MALDI-TOF-MS analysis allowed the acquisition of labile toxin subunit B (LTB) molecular weight and preliminary structural characterization of LTB toxin. MALDI-TOF analysis after reduction and alkylation of the protein evidenced the presence of one disulfide bond in the structure of the protein. Confirmatory analysis was carried out by detection of most of the tryptic fragments of the B subunit by MALDI-TOF-MS, obtaining total coverage of the protein sequence. Possible biovariations in the toxin can mostly be determined by sequencing, where an increase of molecular mass in the N-terminal side of the protein was identified. This modification may be due to an O-GlcNAc-1-phosphorylation. PMID:22921353

  1. The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits.

    Directory of Open Access Journals (Sweden)

    John C Hu

    Full Text Available Poor immune responses elicited by vaccine antigens can be enhanced by the use of appropriate adjuvants. Type II heat-labile enterotoxins (HLT produced by Escherichia coli are extremely potent adjuvants that augment both humoral and cellular immunity to co-administered antigens. Recent findings demonstrate that LT-IIb and LT-IIc, two type II HLT adjuvants, exhibit potent, yet distinguishable CD8(+ T cell adjuvant properties. While LT-IIc elicits a robust and rapid response at one week after administration, LT-IIb engenders a more gradual and slower expansion of antigen-specific CD8(+ T cells that correlates with improved immunity. The variations in immune effects elicited by the HLT adjuvants have been generally attributed to their highly divergent B subunits that mediate binding to various gangliosides on cell surfaces. Yet, HLT adjuvants with point mutations in the B subunit that significantly alter ganglioside binding retain similar adjuvant functions. Therefore, the contribution of the B subunits to adjuvanticity remains unclear. To investigate the influence of the B subunits on the enhancement of immune responses by LT-IIb and LT-IIc, chimeric HLT were engineered in which the B subunits of the two adjuvants were exchanged. Comparing the immune potentiating characteristics of both native and chimeric HLT adjuvants, it was found that not all the adjuvant characteristics of the HLT adjuvants were modulated by the respective B subunits. Specifically, the differences in the CD8(+ T cell kinetics and protective responses elicited by LT-IIb and LT-IIc did indeed followed their respective B subunits. However, induction of IL-1 from macrophages and the capacity to intoxicate cells in a mouse Y1 adrenal cell bioassay did not correlate with the B subunits. Therefore, it is likely that additional factors other than the B subunits contribute to the effects elicited by the HLT adjuvants.

  2. LT-IIb(T13I, a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity.

    Directory of Open Access Journals (Sweden)

    Christopher J Greene

    Full Text Available Currently, there is a shortage of adjuvants that can be employed with protein subunit vaccines to enhance protection against biological threats. LT-IIb(T13I is an engineered nontoxic derivative of LT-IIb, a member of the type II subfamily of heat labile enterotoxins expressed by Escherichia coli, that possesses potent mucosal adjuvant properties. In this study we evaluated the capacity of LT-IIb(T13I to augment the potency of RiVax, a recombinant ricin toxin A subunit vaccine, when co-administered to mice via the intradermal (i.d. and intranasal (i.n. routes. We report that co-administration of RiVax with LT-IIb(T13I by the i.d. route enhanced the levels of RiVax-specific serum IgG antibodies (Ab and elevated the ratio of ricin-neutralizing to non-neutralizing Ab, as compared to RiVax alone. Protection against a lethal ricin challenge was also augmented by LT-IIb(T13I. While local inflammatory responses elicited by LT-IIb(T13I were comparable to those elicited by aluminum salts (Imject®, LT-IIb(T13I was more effective than aluminum salts at augmenting production of RiVax-specific serum IgG. Finally, i.n. administration of RiVax with LT-IIb(T13I also increased levels of RiVax-specific serum and mucosal Ab and enhanced protection against ricin challenge. Collectively, these data highlight the potential of LT-IIb(T13I as an effective next-generation i.d., or possibly i.n. adjuvant for enhancing the immunogenicity of subunit vaccines for biodefense.

  3. Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen.

    Directory of Open Access Journals (Sweden)

    John C Hu

    Full Text Available Vaccinations are extremely effective at combating infectious diseases. Many conserved antigen (Ag targets, however, are poorly immunogenic. Protein subunit vaccines frequently elicit only humoral immune responses and fail to confer protection against serious intracellular pathogens. These barriers to vaccine development are often overcome by the use of appropriate adjuvants. Heat-labile enterotoxins (HLT produced by enterotoxigenic strains of Escherichia coli are potent adjuvants when administered by mucosal or systemic routes. The efficacy of the type II HLT, however, has not been well-defined when administered by the intradermal (ID route. Using a murine ID immunization model, the adjuvant properties of LT-IIb and LT-IIc, two type II HLTs, were compared with those of LT-I, a prototypical type I HLT. While all three HLT adjuvants enhanced Ag-specific humoral responses to similar levels, LT-IIb and LT-IIc, in contrast to LT-I, induced a more vigorous Ag-specific CD8+ T cell response and proffered faster clearance of Listeria monocytogenes in a challenge model. Additionally, LT-IIb and LT-IIc induced distinct differences in the profiles of the Ag-specific CD8+ T cell responses. While LT-IIc stimulated a robust and rapid primary CD8+ T cell response, LT-IIb exhibited slower CD8+ T cell expansion and contraction kinetics with the formation of higher percentages of effector memory cells. In comparison to LT-I and LT-IIc, LT-IIb evoked better long-term protection after immunization. Furthermore, LT-IIb and LT-IIc enhanced the total number of dendritic cells (DC in the draining lymph node (DLN and expression of costimulatory molecules CD80, CD86, and CD40 on DCs. In contrast to LT-I, LT-IIb and LT-IIc induced less edema, cellular infiltrates, and general inflammation at the site of ID injection. Thus, LT-IIb and LT-IIc are attractive comprehensive ID adjuvants with unique characteristic that enhance humoral and cellular immunity to a co

  4. Genetic fusions of a CFA/I/II/IV MEFA (multiepitope fusion antigen and a toxoid fusion of heat-stable toxin (STa and heat-labile toxin (LT of enterotoxigenic Escherichia coli (ETEC retain broad anti-CFA and antitoxin antigenicity.

    Directory of Open Access Journals (Sweden)

    Xiaosai Ruan

    Full Text Available Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunologically different colonization factor antigens (CFAs and two distinct enterotoxins [heat-labile toxin (LT and heat-stable toxin type Ib (STa or hSTa]. ETEC strains expressing any one or two CFAs and either toxin cause diarrhea, therefore vaccines inducing broad immunity against a majority of CFAs, if not all, and both toxins are expected to be effective against ETEC. In this study, we applied the multiepitope fusion antigen (MEFA strategy to construct ETEC antigens and examined antigens for broad anti-CFA and antitoxin immunogenicity. CFA MEFA CFA/I/II/IV [CVI 2014, 21(2:243-9], which carried epitopes of seven CFAs [CFA/I, CFA/II (CS1, CS2, CS3, CFA/IV (CS4, CS5, CS6] expressed by the most prevalent and virulent ETEC strains, was genetically fused to LT-STa toxoid fusion monomer 3xSTaA14Q-dmLT or 3xSTaN12S-dmLT [IAI 2014, 82(5:1823-32] for CFA/I/II/IV-STaA14Q-dmLT and CFA/I/II/IV-STaN12S-dmLT MEFAs. Mice intraperitoneally immunized with either CFA/I/II/IV-STa-toxoid-dmLT MEFA developed antibodies specific to seven CFAs and both toxins, at levels equivalent or comparable to those induced from co-administration of the CFA/I/II/IV MEFA and toxoid fusion 3xSTaN12S-dmLT. Moreover, induced antibodies showed in vitro adherence inhibition activities against ETEC or E. coli strains expressing these seven CFAs and neutralization activities against both toxins. These results indicated CFA/I/II/IV-STa-toxoid-dmLT MEFA or CFA/I/II/IV MEFA combined with 3xSTaN12S-dmLT induced broadly protective anti-CFA and antitoxin immunity, and suggested their potential application in broadly effective ETEC vaccine development. This MEFA strategy may be generally used in

  5. Genetic fusions of a CFA/I/II/IV MEFA (multiepitope fusion antigen) and a toxoid fusion of heat-stable toxin (STa) and heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC) retain broad anti-CFA and antitoxin antigenicity.

    Science.gov (United States)

    Ruan, Xiaosai; Sack, David A; Zhang, Weiping

    2015-01-01

    Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC) strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunologically different colonization factor antigens (CFAs) and two distinct enterotoxins [heat-labile toxin (LT) and heat-stable toxin type Ib (STa or hSTa)]. ETEC strains expressing any one or two CFAs and either toxin cause diarrhea, therefore vaccines inducing broad immunity against a majority of CFAs, if not all, and both toxins are expected to be effective against ETEC. In this study, we applied the multiepitope fusion antigen (MEFA) strategy to construct ETEC antigens and examined antigens for broad anti-CFA and antitoxin immunogenicity. CFA MEFA CFA/I/II/IV [CVI 2014, 21(2):243-9], which carried epitopes of seven CFAs [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, was genetically fused to LT-STa toxoid fusion monomer 3xSTaA14Q-dmLT or 3xSTaN12S-dmLT [IAI 2014, 82(5):1823-32] for CFA/I/II/IV-STaA14Q-dmLT and CFA/I/II/IV-STaN12S-dmLT MEFAs. Mice intraperitoneally immunized with either CFA/I/II/IV-STa-toxoid-dmLT MEFA developed antibodies specific to seven CFAs and both toxins, at levels equivalent or comparable to those induced from co-administration of the CFA/I/II/IV MEFA and toxoid fusion 3xSTaN12S-dmLT. Moreover, induced antibodies showed in vitro adherence inhibition activities against ETEC or E. coli strains expressing these seven CFAs and neutralization activities against both toxins. These results indicated CFA/I/II/IV-STa-toxoid-dmLT MEFA or CFA/I/II/IV MEFA combined with 3xSTaN12S-dmLT induced broadly protective anti-CFA and antitoxin immunity, and suggested their potential application in broadly effective ETEC vaccine development. This MEFA strategy may be generally used in multivalent

  6. 热敏肠毒素促进产肠毒素大肠杆菌对小肠上皮细胞系IPEC-J2的黏附的初步研究%HEAT-LABILE ENTEROTOXIN ENHANCES ETEC ADHERENCE TO PORCINE SMALL INTESTINE EPITHELIAL CELL LINE IPEC-J2

    Institute of Scientific and Technical Information of China (English)

    郁磊; 吴娟; 朱国强

    2012-01-01

    本试验利用PCR技术,以K88ac标准株C83902基因组DNA为模板扩增出热敏肠毒素(heat-labile toxins,LT)基因,大小约1.1 kb。将其克隆入表达质粒载体pACYC184,构建和筛选出含正确插入LT基因的pACYC-LT重组质粒。采用同样方法,构建和筛选出两种含点突变LT基因的重组质粒(pACYC-LT72和pACYC-LT192)。进一步将上述重组质粒DNA转化入不表达任何毒素的大肠杆菌SE5000株。GM1-ELISA结果表明,上述重组菌均能在体外正常表达LT毒素蛋白。以猪小肠上皮细胞系IPEC-J2为模型,比较了表达和不表达LT的细菌对细胞黏附性能。数据表明,LT的表达使细菌对肠上皮细胞的黏附效应明显增加(12.3±3.4倍)。两种LT毒素蛋白的单氨基酸突变体的表达证明了LT毒素的ADP核糖基化作用对其增强致病菌对肠细胞的黏附作用是必要的。蛋白激酶A的抑制剂Rp-cAMP、腺苷酸环化酶的抑制剂DDA和LT毒素的受体GM1都可阻断LT毒素对细菌黏附性能的提升作用。%The LT gene with size of 1.1 kb was amplified in PCR using the genomic DNA template of K88ac E.coli strain C83902.The PCR products were digested with the restriction enzymes at each end and then cloned into vector pACYC184.The recombinant LT plasmids were then constructed and confirmed by restriction endonuclease analysis.In addition,two LT variants(pACYC-LT72 and pACYC-LT192)were also constructed,each bearing mutations of amino acid residues in the A subunit(A72R and R192G) that rendered the toxin inactive.The LT expression was confirmed in GM1-ELISA.Porcine small intestine epithelial cell line IPEC-J2 with glycoprotein receptors for bacterial in vitro adhesion was prepared and used in the study.The data demonstrated that elaboration of LT promoted a significant increase in E.coli adherence and the ADP-ribosylation activity was necessary for this process.We also demonstrated that the enhancement of bacterial adherence was blocked by

  7. Nonruminant Nutrition Symposium: Controlling feed cost by including alternative ingredients into pig diets: a review.

    Science.gov (United States)

    Woyengo, T A; Beltranena, E; Zijlstra, R T

    2014-04-01

    Sustained price increases for traditional cereal grain and protein meal feed commodities have forced the pork industry to consider the dietary inclusion of alternative feedstuffs. Crop seed may serve as feedstuffs but their demand as feedstock for human food, biofuel, and bioindustrial products has increased. Together with these products, coproducts such as distillers dried grains with solubles, wheat millrun, and canola meal are produced. As omnivores, pigs are ideally suited to convert these non-human-edible coproducts into high-quality food animal protein. Therefore, coproducts and other low-cost alternative feedstuffs such as pulses and oilseeds can be included in pig diets to reduce feed cost per metric ton of feed. However, inclusion of alternative feedstuffs in pig diets does not necessarily reduce feed cost per kilogram of gain. Therefore, the use of novel and existing feedstuffs in pig diets must be optimized following their characterization for energy and AA profile. Alternative feedstuffs generally have a high content of at least 1 of the following antinutritional factors (ANF): fiber, tannins, glucosinolates, and heat-labile trypsin inhibitors. Several methods can optimize nutrient use of pigs fed alternative feedstuffs by reducing effects of their ANF. These methods include 1) particle size reduction to increase nutrient digestibility, 2) dehulling or scarification to reduce tannin and fiber content of pulses and oilseeds, 3) air classification to create fractions that have a greater content of nutrients and lower content of ANF than the feedstock, 4) heat treatments such as extrusion, toasting, roasting, and micronization to reduce heat-labile ANF, 5) dietary supplementation with fiber-degrading enzymes or predigestion of fibrous feedstuffs or diets with fiber-degrading enzymes to increase dietary nutrient availability, and 6) formulation of diets based on bioavailable AA coefficients. In conclusion, the feeding of alternative ingredients may reduce

  8. Nonruminant Nutrition Symposium: Controlling feed cost by including alternative ingredients into pig diets: a review.

    Science.gov (United States)

    Woyengo, T A; Beltranena, E; Zijlstra, R T

    2014-04-01

    Sustained price increases for traditional cereal grain and protein meal feed commodities have forced the pork industry to consider the dietary inclusion of alternative feedstuffs. Crop seed may serve as feedstuffs but their demand as feedstock for human food, biofuel, and bioindustrial products has increased. Together with these products, coproducts such as distillers dried grains with solubles, wheat millrun, and canola meal are produced. As omnivores, pigs are ideally suited to convert these non-human-edible coproducts into high-quality food animal protein. Therefore, coproducts and other low-cost alternative feedstuffs such as pulses and oilseeds can be included in pig diets to reduce feed cost per metric ton of feed. However, inclusion of alternative feedstuffs in pig diets does not necessarily reduce feed cost per kilogram of gain. Therefore, the use of novel and existing feedstuffs in pig diets must be optimized following their characterization for energy and AA profile. Alternative feedstuffs generally have a high content of at least 1 of the following antinutritional factors (ANF): fiber, tannins, glucosinolates, and heat-labile trypsin inhibitors. Several methods can optimize nutrient use of pigs fed alternative feedstuffs by reducing effects of their ANF. These methods include 1) particle size reduction to increase nutrient digestibility, 2) dehulling or scarification to reduce tannin and fiber content of pulses and oilseeds, 3) air classification to create fractions that have a greater content of nutrients and lower content of ANF than the feedstock, 4) heat treatments such as extrusion, toasting, roasting, and micronization to reduce heat-labile ANF, 5) dietary supplementation with fiber-degrading enzymes or predigestion of fibrous feedstuffs or diets with fiber-degrading enzymes to increase dietary nutrient availability, and 6) formulation of diets based on bioavailable AA coefficients. In conclusion, the feeding of alternative ingredients may reduce

  9. CpG ODN、氢氧化铝和大肠埃希菌不耐热肠毒素无毒突变体联合佐剂对猪轮状病毒△VP8*亚蛋白免疫效果的影响%Influence of CpG ODN, aluminum hydroxide and avirulent E.coil heat-labile enterotoxin mutant combined adjuvant on immune effect of porcine rotavirus △VP8* subunit vaccine

    Institute of Scientific and Technical Information of China (English)

    冉旭华; 魏晓曼; 闻晓波; 曹思; 张峣; 崔玉东

    2015-01-01

    目的 评价CpG ODN、氢氧化铝[Al(OH)3]和大肠埃希菌不耐热肠毒素(heat-labile enterotoxin,LT)无毒突变体联合佐剂对猪轮状病毒(porcine rotavirus,PRV)△VP8*亚蛋白免疫效果的影响.方法 将LT A亚基上63位丝氨酸突变为赖氨酸,构建LT的无毒突变体重组表达质粒pET-30a(+)-LTK63,于E.coli表达重组蛋白LTK63,并进行纯化.将小鼠随机分为LTK63+ Al(OH)3组、CpG ODN+ Al(OH)3组、CpG ODN+ LTK63+ Al(OH)3组及Al(OH)3对照组,将P2-SB-1A △VP8*抗原蛋白分别与各组相应佐剂共同免疫小鼠,均经颈部皮下注射,隔2周免疫1次,共3次,于每次免疫后14 d采血,分离血清,间接ELISA法检测血清抗体效价及IgG亚型;末次免疫2周后,MTT法检测小鼠特异性淋巴细胞的增殖.结果 经双酶切及测序鉴定,重组质粒pET-30a(+)-LTK63构建正确;表达和纯化产物经SDS-PAGE及Western blot分析,均可见相对分子质量约33 000(A亚基)和13 000(B亚基)的目的蛋白条带.二免后,CpG ODN+ LTK63+ Al(OH)3组的抗体滴度显著高于LTK63+ Al(OH)3组、CpG ODN+ Al(OH)3组和Al(OH)3对照组(P< 0.05);末次免疫后2周,CpG ODN+ Al(OH)3组抗体滴度显著高于Al(OH)3对照组、CpG ODN+ LTK63+Al(OH)3组和LTK63+ Al(OH)3组(P<0.001);CpG ODN+ LTK63+Al(OH)3和LTK63+ Al(OH)3组小鼠血清中IgG2a和IgG1水平相当,CpG ODN+ Al(OH)3组血清抗体以IgG2a为主,Al(OH)3对照组血清IgG以IgG1为主;CpGODN+ Al(OH)3组小鼠特异性淋巴细胞的增殖能力最强.结论 CpG ODN+Al(OH)3联合佐剂表现出明显的协同效应,可显著提高小鼠对PRV△VP8*亚蛋白的体液免疫和细胞免疫应答.

  10. Purification of heat labile toxin from Bordetella pertussis vaccine strain 134 employed indigenous technology

    Directory of Open Access Journals (Sweden)

    K.C. Shivanandappa

    2016-06-01

    Conclusion: The B. pertussis HLT could be purified through two phase with G50 and DEAE, cost effective techniques, the G50 purification has reduced the bioburden problems during DEAE purification and at the same time the quality of the product was high.

  11. Detergent inhibited, heat labile nucleoside triphosphatase in cores of avian myeloblastosis virus

    DEFF Research Database (Denmark)

    Jensen, Kaj Frank

    1978-01-01

    Endogenous DNA synthesis was studied in isolated core particles of avian myeloblastosis virus. It was found that cores contained an enzymatic activity which rapidly converted the added nucleoside triphosphates to diphosphates (but not further) at 0 degrees C, thus inhibiting DNA synthesis. This t...... triphosphatase probably originates from the viral membranes. In the cores the enzyme is completely inactivated by low concentrations (0.02%) of Nonident P-40. Also, the enzyme is very thermolabile and denatures rapidly at 38 degrees C....

  12. Analysis of heat-labile sites generated by reactions of depleted uranium and ascorbate in plasmid DNA.

    Science.gov (United States)

    Wilson, Janice; Young, Ashley; Civitello, Edgar R; Stearns, Diane M

    2014-01-01

    The goal of this study was to characterize how depleted uranium (DU) causes DNA damage. Procedures were developed to assess the ability of organic and inorganic DNA adducts to convert to single-strand breaks (SSB) in pBR322 plasmid DNA in the presence of heat or piperidine. DNA adducts formed by methyl methanesulfonate, cisplatin, and chromic chloride were compared with those formed by reaction of uranyl acetate and ascorbate. Uranyl ion in the presence of ascorbate produced U-DNA adducts that converted to SSB on heating. Piperidine, which acted on DNA methylated by methyl methanesulfonate to convert methyl-DNA adducts to SSB, served in the opposite fashion as U-DNA adducts by decreasing the level of SSB. The observation that piperidine also decreased the gel shift for metal-DNA adducts formed by monofunctional cisplatin and chromic chloride was interpreted to suggest that piperidine served to remove U-DNA adducts. Radical scavengers did not affect the formation of uranium-induced SSB, suggesting that SSB arose from the presence of U-DNA adducts and not from the presence of free radicals. A model is proposed to predict how U-DNA adducts may serve as initial lesions that convert to SSB or AP sites. The results suggest that DU can act as a chemical genotoxin that does not require radiation for its mode of action. Characterizing the DNA lesions formed by DU is necessary to assess the relative importance of different DNA lesions in the formation of DU-induced mutations. Understanding the mechanisms of formation of DU-induced mutations may contribute to identification of biomarkers of DU exposure in humans. PMID:24218036

  13. In Vitro Effects of a High-Molecular-Weight Heat-Labile Enterotoxin from Enteroaggregative Escherichia coli

    OpenAIRE

    Navarro-García, Fernando; Eslava, Carlos; Villaseca, Jorge M.; López-Revilla, Rubén; Czeczulin, John R.; Srinivas, S.; James P. Nataro; Cravioto, Alejandro

    1998-01-01

    The pathogenic mechanisms of enteroaggregative Escherichia coli (EAggEC) infection are not fully elucidated. In this work we show that an ammonium sulfate precipitate of culture supernatant of EAggEC strain 049766 increased the potential difference (PD) and the short-circuit current (Isc) in rat jejunal preparations mounted in Ussing chambers. The precipitate contained two major proteins of 108 and 116 kDa, which were partially copurified by chromatography in DEAE-cellulose. This chromatograp...

  14. Non-toxic variants of the Escherichia coli heat-labile enterotoxin as mucosal immunogens and adjuvants

    NARCIS (Netherlands)

    de Haan, L; Verweij, WR; Feil, IK; Holtrop, M; Hol, WGJ; Agsteribbe, E; Wilschut, J

    1998-01-01

    The mucosal route of vaccination offers the possibility to induce locally produced and secreted IgA antibodies, which are known to play a key role in host defense. In addition, local immunization may result in the induction of substantial levels of serum antibodies, and therefore represents an attra

  15. Optical modulator including grapene

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  16. Analytic device including nanostructures

    KAUST Repository

    Di, Fabrizio, E.

    2015-07-02

    A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.

  17. Theory including future not excluded

    DEFF Research Database (Denmark)

    Nagao, K.; Nielsen, H.B.

    2013-01-01

    , Ehrenfest's theorem, and the conserved probability current density. In addition,we showthat the expectation value at the present time t of a future-included theory for large T - t and large t - T corresponds to that of a future-not-included theory with a proper inner product for large t - T. Hence, the CAT......We study a complex action theory (CAT) whose path runs over not only past but also future. We show that, if we regard a matrix element defined in terms of the future state at time T and the past state at time TA as an expectation value in the CAT, then we are allowed to have the Heisenberg equation...

  18. Biodiversity conservation including uncharismatic species

    DEFF Research Database (Denmark)

    Muñoz, Joaquin

    2007-01-01

    Recent papers mention ideas on the topics of biodiversity conservation strategies and priorities (Redford et al. 2003; Lamoreux et al. 2006; Rodrı´guez et al. 2006), the current status of biodiversity (Loreau et al. 2006), the obligations of conservation biologists regarding management policies...... (Chapron 2006; Schwartz 2006), and the main threats to biodiversity (including invasive species) (Bawa 2006). I suggest, however, that these articles do not really deal with biodiversity. Rather, they all focus on a few obviously charismatic groups (mammals, birds, some plants, fishes, human culture...

  19. Enhanced immunization after intranasal coadministration of Escherichia coli heat-labile enterotoxin B subunit and human papillomavirus 16-L1 DNA vaccine

    Institute of Scientific and Technical Information of China (English)

    WANG Jing; ZHAO Chang-an; WANG Kai; ZHENG Jin; WANG Yi-li; SI Lü-sheng

    2006-01-01

    @@ Human papillomavirus (HPV), mainly types 16 and 18, are the most important initiating agents of cervical cancer.1 Prevention of high-risk HPV infections is a potentially effective approach to control HPV associated cervical cancer.

  20. In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli

    OpenAIRE

    Liang, Shuang; Hosur, Kavita B.; Nawar, Hesham F.; Russell, Michael W.; Terry D Connell; Hajishengallis, George

    2009-01-01

    The pentameric B subunit of the Escherichia coli LT-IIb enterotoxin (LT-IIb-B5) activates TLR2 signaling in macrophages. Herein we demonstrate that LT-IIb-B5, in contrast to a TLR2-nonbinding point mutant, induces functional activation of bone marrow-derived dendritic cells and stimulates CD4+ T cell proliferation, activities which suggested that LT-IIb-B5 might function as an adjuvant in vivo. Indeed, in an intranasal mouse immunization model, LT-IIb-B5 augmented specific mucosal and serum a...

  1. Families classification including multiopposition asteroids

    Science.gov (United States)

    Milani, Andrea; Spoto, Federica; Knežević, Zoran; Novaković, Bojan; Tsirvoulis, Georgios

    2016-01-01

    In this paper we present the results of our new classification of asteroid families, upgraded by using catalog with > 500,000 asteroids. We discuss the outcome of the most recent update of the family list and of their membership. We found enough evidence to perform 9 mergers of the previously independent families. By introducing an improved method of estimation of the expected family growth in the less populous regions (e.g. at high inclination) we were able to reliably decide on rejection of one tiny group as a probable statistical fluke. Thus we reduced our current list to 115 families. We also present newly determined ages for 6 families, including complex 135 and 221, improving also our understanding of the dynamical vs. collisional families relationship. We conclude with some recommendations for the future work and for the family name problem.

  2. Including Magnetostriction in Micromagnetic Models

    Science.gov (United States)

    Conbhuí, Pádraig Ó.; Williams, Wyn; Fabian, Karl; Nagy, Lesleis

    2016-04-01

    The magnetic anomalies that identify crustal spreading are predominantly recorded by basalts formed at the mid-ocean ridges, whose magnetic signals are dominated by iron-titanium-oxides (Fe3-xTixO4), so called "titanomagnetites", of which the Fe2.4Ti0.6O4 (TM60) phase is the most common. With sufficient quantities of titanium present, these minerals exhibit strong magnetostriction. To date, models of these grains in the pseudo-single domain (PSD) range have failed to accurately account for this effect. In particular, a popular analytic treatment provided by Kittel (1949) for describing the magnetostrictive energy as an effective increase of the anisotropy constant can produce unphysical strains for non-uniform magnetizations. I will present a rigorous approach based on work by Brown (1966) and by Kroner (1958) for including magnetostriction in micromagnetic codes which is suitable for modelling hysteresis loops and finding remanent states in the PSD regime. Preliminary results suggest the more rigorously defined micromagnetic models exhibit higher coercivities and extended single domain ranges when compared to more simplistic approaches.

  3. Article Including Environmental Barrier Coating System

    Science.gov (United States)

    Lee, Kang N. (Inventor)

    2015-01-01

    An enhanced environmental barrier coating for a silicon containing substrate. The enhanced barrier coating may include a bond coat doped with at least one of an alkali metal oxide and an alkali earth metal oxide. The enhanced barrier coating may include a composite mullite bond coat including BSAS and another distinct second phase oxide applied over said surface.

  4. Static, Lightweight Includes Resolution for PHP

    NARCIS (Netherlands)

    Hills, M.A.; Klint, P.; Vinju, J.J.

    2014-01-01

    Dynamic languages include a number of features that are challenging to model properly in static analysis tools. In PHP, one of these features is the include expression, where an arbitrary expression provides the path of the file to include at runtime. In this paper we present two complementary analy

  5. Composite Pressure Vessel Including Crack Arresting Barrier

    Science.gov (United States)

    DeLay, Thomas K. (Inventor)

    2013-01-01

    A pressure vessel includes a ported fitting having an annular flange formed on an end thereof and a tank that envelopes the annular flange. A crack arresting barrier is bonded to and forming a lining of the tank within the outer surface thereof. The crack arresting barrier includes a cured resin having a post-curing ductility rating of at least approximately 60% through the cured resin, and further includes randomly-oriented fibers positioned in and throughout the cured resin.

  6. 28 CFR 20.32 - Includable offenses.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Includable offenses. 20.32 Section 20.32 Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history...

  7. Haemophilus influenzae Disease (Including Hib) Symptoms

    Science.gov (United States)

    ... is considered invasive. Symptoms of pneumonia usually include: Fever and chills Cough Shortness of breath or difficulty breathing Sweating ... the blood. It can cause symptoms such as: Fever and chills Excessive tiredness Pain in the belly Nausea with ...

  8. What Does Long-Term Care Include?

    Medline Plus

    Full Text Available Video: "What Does Long-Term Care Include?" Long-term care involves a variety of services designed to meet a person's health or personal care needs during a short or long period of ...

  9. Births and deaths including fetal deaths

    Data.gov (United States)

    U.S. Department of Health & Human Services — Access to a variety of United States birth and death files including fetal deaths: Birth Files, 1968-2009; 1995-2005; Fetal death file, 1982-2005; Mortality files,...

  10. Including Indigenous Minorities in Decision-Making

    DEFF Research Database (Denmark)

    Pristed Nielsen, Helene

    Based on theories of public sphere participation and deliberative democracy, this book presents empirical results from a study of experiences with including Aboriginal and Maori groups in political decision-making in respectively Western Australia and New Zealand...

  11. Including excitons in semiconductor solar cell modelling

    OpenAIRE

    Burgelman, Marc; Minnaert, Ben

    2005-01-01

    Excitons are marginally important in classical semiconductor device physics, and their treatment is not included in standard solar cell modelling. However, in organic semiconductors and solar cells, the role of excitons is essential, as the primary effect of light absorption is exciton generation, and free electrons and holes are created by exciton dissociation. First steps to include excitons in solar cell modelling were presented by Green 1996 and Zhang 1998. Their model was restricted to a...

  12. Electric Power Monthly, August 1990. [Glossary included

    Energy Technology Data Exchange (ETDEWEB)

    1990-11-29

    The Electric Power Monthly (EPM) presents monthly summaries of electric utility statistics at the national, Census division, and State level. The purpose of this publication is to provide energy decisionmakers with accurate and timely information that may be used in forming various perspectives on electric issues that lie ahead. Data includes generation by energy source (coal, oil, gas, hydroelectric, and nuclear); generation by region; consumption of fossil fuels for power generation; sales of electric power, cost data; and unusual occurrences. A glossary is included.

  13. 34 CFR 300.20 - Include.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include. 300.20 Section 300.20 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

  14. 46 CFR 289.2 - Vessels included.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Vessels included. 289.2 Section 289.2 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS INSURANCE OF... of this part are: (a) All vessels which may in the future be constructed or sold with...

  15. 42 CFR 409.10 - Included services.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Included services. 409.10 Section 409.10 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM HOSPITAL INSURANCE BENEFITS Inpatient Hospital Services and Inpatient Critical Access Hospital...

  16. Numerical simulation of spark ignition including ionization

    NARCIS (Netherlands)

    Thiele, M; Selle, S; Riedel, U; Warnatz, J; Maas, U

    2000-01-01

    A detailed understanding of the processes associated Midi spark ignition, as a first step during combustion, is of great importance fur clean operation of spark ignition engines. In the past 10 years. a growing concern for environmental protection, including low emission of pollutants, has increased

  17. [Biophysical Characterization of Biopharmaceuticals, Including Antibody Drugs].

    Science.gov (United States)

    Uchiyama, Susumu

    2016-01-01

    Biopharmaceuticals, including antibody drugs, are now popular because of their high specificity with low adverse effects, especially in the treatment of cancer and autoimmune diseases. However, because the active pharmaceutical ingredients of biopharmaceuticals are proteins, biophysical characterization of these therapeutic proteins should be required. In this manuscript, methods of chemical and physical characterization of therapeutic proteins are described. In terms of chemical characterization, analysis of chemical modifications of the constituent amino acids is explained. Physical characterization includes higher order structural analysis and assessment of protein aggregates. Quantification methods of aggregates with different sizes, recently encouraged by the U.S. Food and Drug Administration (FDA), are introduced. As for the stability of therapeutic proteins, the importance of chemical and physical stability is explained. Finally, the contribution of colloidal and structural stability to the production of an antibody drug less prone to aggregation is introduced.

  18. Electric power monthly, September 1990. [Glossary included

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-17

    The purpose of this report is to provide energy decision makers with accurate and timely information that may be used in forming various perspectives on electric issues. The power plants considered include coal, petroleum, natural gas, hydroelectric, and nuclear power plants. Data are presented for power generation, fuel consumption, fuel receipts and cost, sales of electricity, and unusual occurrences at power plants. Data are compared at the national, Census division, and state levels. 4 figs., 52 tabs. (CK)

  19. Including knowledge creation & enabling in risk management

    OpenAIRE

    Hop, Eirik

    2015-01-01

    As a contribution to Statoil Technical Efficiency Programme (STEP), has the thesis looked at how to improve the risk management process in Statoil ASA. Through theoretical research was the primary research question created: “How can knowledge creation & enabling improve our understanding of risk management?” To create a theoretical foundation, the thesis looked at principles, methods, and models for the adequate assessment and management of risk. This includes a new perspective on ri...

  20. Rotor assembly including superconducting magnetic coil

    Energy Technology Data Exchange (ETDEWEB)

    Snitchler, Gregory L. (Shrewsbury, MA); Gamble, Bruce B. (Wellesley, MA); Voccio, John P. (Somerville, MA)

    2003-01-01

    Superconducting coils and methods of manufacture include a superconductor tape wound concentrically about and disposed along an axis of the coil to define an opening having a dimension which gradually decreases, in the direction along the axis, from a first end to a second end of the coil. Each turn of the superconductor tape has a broad surface maintained substantially parallel to the axis of the coil.

  1. Including heavy flavour production in PDF fits

    OpenAIRE

    A.M. Cooper-Sarkar

    2007-01-01

    AT HERA heavy quarks may contribute up to 30% of the structure function $F_2$. The introduction of heavy quarks requires an extension of the DGLAP formalism. The effect of using different heavy flavour number schemes, and different approaches to the running of $\\alpha_s$, are compared using the ZEUS PDF fit formalism. The potential of including charm data in the fit is explored, using $D^*$ double differential cross-sections rather than the inclusive quantity $F_2^{c\\bar{c}}$.

  2. A kicked quantum system including the continuum

    International Nuclear Information System (INIS)

    The behaviour of a quantum particle in a separable one-term potential with three-dimensional form factor is investigated under the influence of an external force which alters the potential strength periodically or quasiperiodically. The unperturbed system possesses one bound state and a continuum of scattering states which has treated almost analytically. First numerical results, fully including the emission channel, indicate, for certain parameter combinations with commensurate or incommensurate frequency ratios, either a regular or an irregular dynamical behaviour of the system. 17 refs.; 3 figs

  3. Drug delivery device including electrolytic pump

    KAUST Repository

    Foulds, Ian G.

    2016-03-31

    Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

  4. Musculoskeletal ultrasound including definitions for ultrasonographic pathology

    DEFF Research Database (Denmark)

    Wakefield, RJ; Balint, PV; Szkudlarek, Marcin;

    2005-01-01

    Ultrasound (US) has great potential as an outcome in rheumatoid arthritis trials for detecting bone erosions, synovitis, tendon disease, and enthesopathy. It has a number of distinct advantages over magnetic resonance imaging, including good patient tolerability and ability to scan multiple joints...... pathologies. This article presents the first report from the OMERACT ultrasound special interest group, which has compared US against the criteria of the OMERACT filter. Also proposed for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis....

  5. Inlet Guide Vane Wakes Including Rotor Effects

    Science.gov (United States)

    Johnston, R. T.; Fleeter, S.

    2001-02-01

    Fundamental experiments are described directed at the investigation of forcing functions generated by an inlet guide vane (IGV) row, including interactions with the downstream rotor, for application to turbomachine forced response design systems. The experiments are performed in a high-speed research fan facility comprised of an IGV row upstream of a rotor. IGV-rotor axial spacing is variable, with the IGV row able to be indexed circumferentially, thereby allowing measurements to be made across several IGV wakes. With an IGV relative Mach number of 0.29, measurements include the IGV wake pressure and velocity fields for three IGV-rotor axial spacings. The decay characteristics of the IGV wakes are compared to the Majjigi and Gliebe empirical correlations. After Fourier decomposition, a vortical-potential gust splitting analysis is implemented to determine the vortical and potential harmonic wake gust forcing functions both upstream and downstream of the rotor. Higher harmonics of the vortical gust component of the IGV wakes are found to decay at a uniform rate due to viscous diffusion.

  6. Aerosol simulation including chemical and nuclear reactions

    Energy Technology Data Exchange (ETDEWEB)

    Marwil, E.S.; Lemmon, E.C.

    1985-01-01

    The numerical simulation of aerosol transport, including the effects of chemical and nuclear reactions presents a challenging dynamic accounting problem. Particles of different sizes agglomerate and settle out due to various mechanisms, such as diffusion, diffusiophoresis, thermophoresis, gravitational settling, turbulent acceleration, and centrifugal acceleration. Particles also change size, due to the condensation and evaporation of materials on the particle. Heterogeneous chemical reactions occur at the interface between a particle and the suspending medium, or a surface and the gas in the aerosol. Homogeneous chemical reactions occur within the aersol suspending medium, within a particle, and on a surface. These reactions may include a phase change. Nuclear reactions occur in all locations. These spontaneous transmutations from one element form to another occur at greatly varying rates and may result in phase or chemical changes which complicate the accounting process. This paper presents an approach for inclusion of these effects on the transport of aerosols. The accounting system is very complex and results in a large set of stiff ordinary differential equations (ODEs). The techniques for numerical solution of these ODEs require special attention to achieve their solution in an efficient and affordable manner. 4 refs.

  7. Models of bovine babesiosis including juvenile cattle.

    Science.gov (United States)

    Saad-Roy, C M; Shuai, Zhisheng; van den Driessche, P

    2015-03-01

    Bovine Babesiosis in cattle is caused by the transmission of protozoa of Babesia spp. by ticks as vectors. Juvenile cattle (resistance to Bovine Babesiosis, rarely show symptoms, and acquire immunity upon recovery. Susceptibility to the disease varies between breeds of cattle. Models of the dynamics of Bovine Babesiosis transmitted by the cattle tick that include these factors are formulated as systems of ordinary differential equations. Basic reproduction numbers are calculated, and it is proved that if these numbers are below the threshold value of one, then Bovine Babesiosis dies out. However, above the threshold number of one, the disease may approach an endemic state. In this case, control measures are suggested by determining target reproduction numbers. The percentage of a particular population (for example, the adult bovine population) needed to be controlled to eradicate the disease is evaluated numerically using Columbia data from the literature. PMID:25715822

  8. CLIC expands to include the Southern Hemisphere

    CERN Multimedia

    Roberto Cantoni

    2010-01-01

    Australia has recently joined the CLIC collaboration: the enlargement will bring new expertise and resources to the project, and is especially welcome in the wake of CERN budget redistributions following the recent adoption of the Medium Term Plan.   The countries involved in CLIC collaboration With the signing of a Memorandum of Understanding on 26 August 2010, the ACAS network (Australian Collaboration for Accelerator Science) became the 40th member of in the multilateral CLIC collaboration making Australia the 22nd country to join the collaboration. “The new MoU was signed by the ACAS network, which includes the Australian Synchrotron and the University of Melbourne”, explains Jean-Pierre Delahaye, CLIC Study Leader. “Thanks to their expertise, the Australian institutes will contribute greatly to the CLIC damping rings and the two-beam test modules." Institutes from any country wishing to join the CLIC collaboration are invited to assume responsibility o...

  9. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of the "LabView Basic I" and "LabView Intermediate II" courses have recently been changed to include, respectively, an introduction to and expert training in the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to developing expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course pr...

  10. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of "LabView Basic I" and "LabView Intermediate II" trainings have been recently changed to include, respectively, an introduction and an expert training on the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to develop expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course prepare...

  11. CERN Technical Training: LABVIEW courses include RADE

    CERN Multimedia

    HR Department

    2009-01-01

    The contents of the "LabView Basic I" and "LabView Intermediate II" courses have recently been changed to include, respectively, an introduction to and expert training in the Rapid Application Development Environment (RADE). RADE is a LabView-based application developed at CERN to integrate LabView in the accelerator and experiment control infrastructure. It is a suitable solution to developing expert tools, machine development analysis and independent test facilities. The course names have also been changed to "LabVIEW Basics I with RADE Introduction" and "LabVIEW Intermediate II with Advanced RADE Application". " LabVIEW Basics I with RADE Introduction" is designed for: Users preparing to develop applications using LabVIEW, or NI Developer Suite; users and technical managers evaluating LabVIEW or NI Developer Suite in purchasing decisions; users pursuing the Certified LabVIEW Developer certification. The course prepares participants to develop test and measurement, da...

  12. Critical point anomalies include expansion shock waves

    Energy Technology Data Exchange (ETDEWEB)

    Nannan, N. R., E-mail: ryan.nannan@uvs.edu [Mechanical Engineering Discipline, Anton de Kom University of Suriname, Leysweg 86, PO Box 9212, Paramaribo, Suriname and Process and Energy Department, Delft University of Technology, Leeghwaterstraat 44, 2628 CA Delft (Netherlands); Guardone, A., E-mail: alberto.guardone@polimi.it [Department of Aerospace Science and Technology, Politecnico di Milano, Via La Masa 34, 20156 Milano (Italy); Colonna, P., E-mail: p.colonna@tudelft.nl [Propulsion and Power, Delft University of Technology, Kluyverweg 1, 2629 HS Delft (Netherlands)

    2014-02-15

    From first-principle fluid dynamics, complemented by a rigorous state equation accounting for critical anomalies, we discovered that expansion shock waves may occur in the vicinity of the liquid-vapor critical point in the two-phase region. Due to universality of near-critical thermodynamics, the result is valid for any common pure fluid in which molecular interactions are only short-range, namely, for so-called 3-dimensional Ising-like systems, and under the assumption of thermodynamic equilibrium. In addition to rarefaction shock waves, diverse non-classical effects are admissible, including composite compressive shock-fan-shock waves, due to the change of sign of the fundamental derivative of gasdynamics.

  13. Including electronic effects in damage cascade simulations

    International Nuclear Information System (INIS)

    A method for including the effects of electronic losses and electron-phonon coupling in radiation damage simulations has been developed and implemented for 10 keV cascades in Fe. The MD simulations are coupled to a continuum model for the electronic energy and energy lost by the atoms, due to electronic friction and electron-phonon coupling, is gained by electronic system. Electronic energy transport is described by the heat diffusion equation and energy is returned to the lattice via a stochastic force. Thus the temperature of the atomic system is controlled by a Langevin thermostat at the local electronic temperature, which varies with time and space. The results of simulations with this inhomogeneous thermostat are compared with those of homogeneous (constant temperature) thermostat simulations for a range of electron-phonon coupling strengths. The residual defect concentration was found to have a non-monotonic variation with coupling strength.

  14. The surgery of peripheral nerves (including tumors)

    DEFF Research Database (Denmark)

    Fugleholm, Kåre

    2013-01-01

    Surgical pathology of the peripheral nervous system includes traumatic injury, entrapment syndromes, and tumors. The recent significant advances in the understanding of the pathophysiology and cellular biology of peripheral nerve degeneration and regeneration has yet to be translated into improved...... surgical techniques and better outcome after peripheral nerve injury. Decision making in peripheral nerve surgery continues to be a complex challenge, where the mechanism of injury, repeated clinical evaluation, neuroradiological and neurophysiological examination, and detailed knowledge of the peripheral...... nervous system response to injury are prerequisite to obtain the best possible outcome. Surgery continues to be the primary treatment modality for peripheral nerve tumors and advances in adjuvant oncological treatment has improved outcome after malignant peripheral nerve tumors. The present chapter...

  15. ACCREDITATION FOR TECHNICAL ABILITIES INCLUDING COMPUTER SKILLS

    Directory of Open Access Journals (Sweden)

    Halit Hami OZ

    2013-01-01

    Full Text Available Sector Skills are defined by state-sponsored, employer-led organizations that cover specific economic sectors in the European Union and other countries in the world to reduce skills gaps and shortages, improve productivity, boost the skills of their sector workforces and improve learning supply. The accreditation and registration systems used by professional bodies raise the profile of the profession. In many countries including the European Union, professional associations are beginning to accept practice-based accreditation, generally as an alternative to their mainstream systems. Besides studying the certain agencies in the European Union for assessing/accreditating practical abilities , Accreditation for practical abilities of Information Communication Technology and Business Management/Language domains developed by Accreditation Council for Practical abilities are also studied in detail as an example to establish a similar agency in Turkey.

  16. AMS at the ANU including biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Fifield, L.K.; Allan, G.L.; Cresswell, R.G.; Ophel, T.R. [Australian National Univ., Canberra, ACT (Australia); King, S.J.; Day, J.P. [Manchester Univ. (United Kingdom). Dept. of Chemistry

    1993-12-31

    An extensive accelerator mass spectrometry program has been conducted on the 14UD accelerator at the Australian National University since 1986. In the two years since the previous conference, the research program has expanded significantly to include biomedical applications of {sup 26}Al and studies of landform evolution using isotopes produced in situ in surface rocks by cosmic ray bombardment. The system is now used for the measurement of {sup 10}Be, {sup 14}C, {sup 26}Al, {sup 36}Cl, {sup 59}Ni and {sup 129}I, and research is being undertaken in hydrology, environmental geochemistry, archaeology and biomedicine. On the technical side, a new test system has permitted the successful off-line development of a high-intensity ion source. A new injection line to the 14UD has been established and the new source is now in position and providing beams to the accelerator. 4 refs.

  17. Thermovoltaic semiconductor device including a plasma filter

    Science.gov (United States)

    Baldasaro, Paul F.

    1999-01-01

    A thermovoltaic energy conversion device and related method for converting thermal energy into an electrical potential. An interference filter is provided on a semiconductor thermovoltaic cell to pre-filter black body radiation. The semiconductor thermovoltaic cell includes a P/N junction supported on a substrate which converts incident thermal energy below the semiconductor junction band gap into electrical potential. The semiconductor substrate is doped to provide a plasma filter which reflects back energy having a wavelength which is above the band gap and which is ineffectively filtered by the interference filter, through the P/N junction to the source of radiation thereby avoiding parasitic absorption of the unusable portion of the thermal radiation energy.

  18. Input parameters and scenarios, including economic inputs

    DEFF Research Database (Denmark)

    Boklund, Anette; Hisham Beshara Halasa, Tariq

    2012-01-01

    Geographical locations of the farms are the core in these models. We used geographical data, number of animals and specification of herd types for the 50,853 herds in the Danish Husbandry Register (CHR) in 2007. For each herd, the daily probability of moving animals, to another herd or to the aba......Geographical locations of the farms are the core in these models. We used geographical data, number of animals and specification of herd types for the 50,853 herds in the Danish Husbandry Register (CHR) in 2007. For each herd, the daily probability of moving animals, to another herd......, disease was simulated to spread via direct contacts (movements of animals), indirect contacts (trucks and persons) and local spread (mice, birds, airborne spread in limited distances). Furthermore, in some scenarios airborne spread was included. For all contact types, when a contact was simulated to take...... place, a receiving herd needed to be found. The distance, in which the receiving herd should be found, was calculated from movement data for animals and from data from trucks and abattoirs for movements to slaughter and milk tankers. For persons visiting herds, we used a combination of expert opinions...

  19. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    Science.gov (United States)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    The dilemma of designing an advanced undergraduate laboratory lies in the desire to teach and reinforce basic principles and techniques while at the same time exposing students to the excitement of research. We report here on a one-semester, project-based biochemistry laboratory that combines the best features of a cookbook approach (high success rate, achievement of defined goals) with those of an investigative, discovery-based approach (student involvement in the experimental design, excitement of real research). Individual modules may be selected and combined to meet the needs of different courses and different institutions. The central theme of this lab is protein purification and design. This laboratory accompanies the first semester of biochemistry (Structure and Function of Macromolecules, a course taken mainly by junior and senior chemistry and biological chemistry majors). The protein chosen as the object of study is the enzyme lysozyme, which is utilized in all projects. It is suitable for a student lab because it is easily and inexpensively obtained from egg white and is extremely stable, and its high isoelectric point (pI = 11) allows for efficient separation from other proteins by ion-exchange chromatography. Furthermore, a literature search conducted by the resourceful student reveals a wealth of information, since lysozyme has been the subject of numerous studies. It was the first enzyme whose structure was determined by crystallography (1). Hendrickson et al. (2) have previously described an intensive one-month laboratory course centered around lysozyme, although their emphasis is on protein stability rather than purification and engineering. Lysozyme continues to be the focus of much exciting new work on protein folding and dynamics, structure and activity (3 - 5). This lab course includes the following features: (i) reinforcement of basic techniques, such as preparation of buffers, simple enzyme kinetics, and absorption spectroscopy; (ii

  20. SEEPAGE MODEL FOR PA INCLUDING DRIFT COLLAPSE

    Energy Technology Data Exchange (ETDEWEB)

    C. Tsang

    2004-09-22

    The purpose of this report is to document the predictions and analyses performed using the seepage model for performance assessment (SMPA) for both the Topopah Spring middle nonlithophysal (Tptpmn) and lower lithophysal (Tptpll) lithostratigraphic units at Yucca Mountain, Nevada. Look-up tables of seepage flow rates into a drift (and their uncertainty) are generated by performing numerical simulations with the seepage model for many combinations of the three most important seepage-relevant parameters: the fracture permeability, the capillary-strength parameter 1/a, and the percolation flux. The percolation flux values chosen take into account flow focusing effects, which are evaluated based on a flow-focusing model. Moreover, multiple realizations of the underlying stochastic permeability field are conducted. Selected sensitivity studies are performed, including the effects of an alternative drift geometry representing a partially collapsed drift from an independent drift-degradation analysis (BSC 2004 [DIRS 166107]). The intended purpose of the seepage model is to provide results of drift-scale seepage rates under a series of parameters and scenarios in support of the Total System Performance Assessment for License Application (TSPA-LA). The SMPA is intended for the evaluation of drift-scale seepage rates under the full range of parameter values for three parameters found to be key (fracture permeability, the van Genuchten 1/a parameter, and percolation flux) and drift degradation shape scenarios in support of the TSPA-LA during the period of compliance for postclosure performance [Technical Work Plan for: Performance Assessment Unsaturated Zone (BSC 2002 [DIRS 160819], Section I-4-2-1)]. The flow-focusing model in the Topopah Spring welded (TSw) unit is intended to provide an estimate of flow focusing factors (FFFs) that (1) bridge the gap between the mountain-scale and drift-scale models, and (2) account for variability in local percolation flux due to

  1. Including lifestyle medicine in undergraduate medical curricula

    Directory of Open Access Journals (Sweden)

    Edward Phillips

    2015-02-01

    Full Text Available Purpose: Currently, there is no model to integrate the discipline of lifestyle medicine (LM into undergraduate medical education. Furthermore, there are no guidelines, validated assessment tools, or evaluation or implementation plans in place. Background: The World Health Organization predicts that by 2020, two-thirds of disease worldwide will be the result of poor lifestyle choices. Fewer than 50% of US primary care physicians routinely provide specific guidance on nutrition, physical activity, or weight control. Methods: We are establishing a plan to integrate LM into medical school education in collaboration with the investing stakeholders, including medical school deans and students, medical curriculum developers and researchers, medical societies, governing bodies, and policy institutes. Three planning and strategy meetings are being held to address key areas of focus – with a particular interest in nutrition, physical activity, student self-care, and behavior change – to develop specific implementation guidelines and landmarks. Results: After the first two meetings, the proposed areas of focus were determined to be: 1 supporting of deans and key personnel, 2 creation of federal and state policy commitments, 3 use of assessment as a driver of LM, 4 provision of high-quality evidence-based curricular material on an easily navigated site, and 5 engaging student interest. Implementation strategies for each focus area will be addressed in an upcoming planning meeting in early 2015. Conclusion: This initiative is expected to have important public health implications by efficiently promoting the prevention and treatment of non-communicable chronic disease with a scalable and sustainable model to educate physicians in training and practice.

  2. Ionic liquids, electrolyte solutions including the ionic liquids, and energy storage devices including the ionic liquids

    Energy Technology Data Exchange (ETDEWEB)

    Gering, Kevin L.; Harrup, Mason K.; Rollins, Harry W.

    2015-12-08

    An ionic liquid including a phosphazene compound that has a plurality of phosphorus-nitrogen units and at least one pendant group bonded to each phosphorus atom of the plurality of phosphorus-nitrogen units. One pendant group of the at least one pendant group comprises a positively charged pendant group. Additional embodiments of ionic liquids are disclosed, as are electrolyte solutions and energy storage devices including the embodiments of the ionic liquid.

  3. Faults of Europe including Turkey (flt4_2l)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This coverage includes arcs that describe faults found in the surface outcrops of bedrock of Europe including Turkey (Albania, Andorra, Austria, Belgium, Bosnia and...

  4. Partially ionized plasmas including the third symposium on uranium plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, M. [ed.

    1976-09-01

    Separate abstracts are included for 28 papers on electrically generated plasmas, fission generated plasmas, nuclear pumped lasers, gaseous fuel reactor research, and applications. Five papers have been previously abstracted and included in ERA.

  5. Should Relational Aggression Be Included in DSM-V?

    Science.gov (United States)

    Keenan, Kate; Coyne, Claire; Lahey, Benjamin B.

    2008-01-01

    The study examines whether relational aggression should be included in DSM-V disruptive behavior disorders. The results conclude that some additional information is gathered from assessing relational aggression but not enough to be included in DSM-V.

  6. 25 CFR 20.403 - What do protective services include?

    Science.gov (United States)

    2010-04-01

    ... for assistance in solving the social problems of individuals, families, and children. (5) Coordinating.../services, including Child Protection, and/or establishing Multi-Disciplinary Teams. (b) Must include, where... account holder; (ii) Developing, as necessary and as permitted under 25 CFR 115, a one-time or an...

  7. Microfluidic devices and methods including porous polymer monoliths

    Science.gov (United States)

    Hatch, Anson V; Sommer, Gregory J; Singh, Anup K; Wang, Ying-Chih; Abhyankar, Vinay V

    2014-04-22

    Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.

  8. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a) Aquaculture is a value loss crop and is compensable only in accord with restrictions set in this...

  9. Solar Energy Education. Reader, Part II. Sun story. [Includes glossary

    Energy Technology Data Exchange (ETDEWEB)

    1981-05-01

    Magazine articles which focus on the subject of solar energy are presented. The booklet prepared is the second of a four part series of the Solar Energy Reader. Excerpts from the magazines include the history of solar energy, mythology and tales, and selected poetry on the sun. A glossary of energy related terms is included. (BCS)

  10. Including Siblings in the Treatment of Child Sexual Abuse.

    Science.gov (United States)

    Baker, Juanita N.; Tanis, Heyley J.; Rice, Jennifer B.

    2001-01-01

    Describes the necessity of including siblings in the treatment of victims of child sexual abuse. Theoretical and practical reasons to include siblings in treatment are discussed. Case examples using a particular intervention approach and results of client satisfaction surveys are described. (Contains 18 references.) (GCP)

  11. 20 CFR 404.1312 - World War II service included.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false World War II service included. 404.1312... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services World War II Veterans § 404.1312 World War II service included. Your service was in the active service of the...

  12. Making Way and Making Sense: Including Newcomers in Interaction

    Science.gov (United States)

    Pillet-Shore, Danielle

    2010-01-01

    In our everyday interactions as they unfold in real time, how do we do including? This article examines a specific set of interactional moments when the potential to be included (or not) recurs: when a newcomer arrives to some social scene where two or more already-present persons are actively engaged in some activity and that newcomer displays…

  13. Treatment Options for Plasma Cell Neoplasms (Including Multiple Myeloma)

    Science.gov (United States)

    ... Treatment Health Professional Plasma Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma Cell Neoplasms Go to Health Professional Version Key ...

  14. Stages of Plasma Cell Neoplasms (Including Multiple Myeloma)

    Science.gov (United States)

    ... Treatment Health Professional Plasma Cell Neoplasms Treatment Research Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Patient Version General Information About Plasma Cell Neoplasms Go to Health Professional Version Key ...

  15. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema Recommend on Facebook Tweet Share Compartir Data are ... of adults who have ever been diagnosed with emphysema: 3.4 million Percent of adults who have ...

  16. Prototype solar heating and cooling systems, including potable hot water

    Science.gov (United States)

    Bloomquist, D.; Oonk, R. L.

    1977-01-01

    Progress made in the development, delivery, and support of two prototype solar heating and cooling systems including potable hot water is reported. The system consists of the following subsystems: collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition. A comparison of the proposed Solaron Heat Pump and Solar Desiccant Heating and Cooling Systems, installation drawings, data on the Akron House at Akron, Ohio, and other program activities are included.

  17. A Framework for Including Family Health Spillovers in Economic Evaluation.

    Science.gov (United States)

    Al-Janabi, Hareth; van Exel, Job; Brouwer, Werner; Coast, Joanna

    2016-02-01

    Health care interventions may affect the health of patients' family networks. It has been suggested that these "health spillovers" should be included in economic evaluation, but there is not a systematic method for doing this. In this article, we develop a framework for including health spillovers in economic evaluation. We focus on extra-welfarist economic evaluations where the objective is to maximize health benefits from a health care budget (the "health care perspective"). Our framework involves adapting the conventional cost-effectiveness decision rule to include 2 multiplier effects to internalize the spillover effects. These multiplier effects express the ratio of total health effects (for patients and their family networks) to patient health effects. One multiplier effect is specified for health benefit generated from providing a new intervention, one for health benefit displaced by funding this intervention. We show that using multiplier effects to internalize health spillovers could change the optimal funding decisions and generate additional health benefits to society.

  18. Multidisciplinary treatment for advanced and recurrent breast cancer including brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Tsukiyama, Iwao; Ohno, Tatsuya (Tochigi Cancer Center, Utsunomiya (Japan). Hospital); Takizawa, Yoshikazu; Ikeda, Hiroshi; Egawa, Sunao; Ogino, Takashi

    1994-06-01

    Between 1986 and 1992, 10 patients (12 lesions) of advanced breast cancer were treated with multidisciplinary treatment including brachytherapy. The lesions treated included 5 primary breast tumors, 3 metastatic lesions in the contra lateral breast, 2 recurrences after external beam irradiation, 1 metastasis to the axillary lymph node and 1 metastasis to the upper arm skin. The interstitial irradiation techniques used were [sup 192]Ir low dose-rate irradiation for 5 lesions and high dose-rate for 7 lesions (including 3 with mould irradiation). External hyperthermia as performed for 6 lesions and interstitial hyperthermia were performed for 4 lesions. The local response was CR for 3 lesions, PRa for 8 lesions, PRb for 1 lesion with the local response rate being 100%. Excellent local control could be achieved by combination external and interstitial irradiation, indicating that radiotherapy is definitely useful for the treatment of advanced breast cancer. (author).

  19. Including patients’ perspectives in patient information leaflets: A polyocular approach

    DEFF Research Database (Denmark)

    Fage-Butler, Antoinette Mary

    2013-01-01

    asymmetries. The paper contributes theoretically in its innovative use of perspectivist theory in relation to text, and in identifying that the insights of polyocularity could valuably inform a new health communication paradigm, as current health communication paradigms do not fully recognize patients......Existing research reveals that patients’ perspectives are missing from mandatory patient information leaflets (PILs). At the same time, there is overwhelming consensus that they should be included in this genre, and a corresponding need for potential approaches to tackle this problem. This paper......’ perspectives. Apart from its theoretical contributions, the paper includes guidelines to support the production of PILs where patients’ perspectives are included. The guidelines are informed by practices that have characterised previous polyocular communication events, as well as research into how to maximize...

  20. Pediatric deformity treatment update, including 3D correction concepts%Pediatric deformity treatment update,including 3D correction concepts

    Institute of Scientific and Technical Information of China (English)

    Randal R. Betz; Patrick J. Cahill; Joshua M. Pahys; Amer F. Samdani

    2011-01-01

    The purpose of this article is to highlight some of the new developments in the treatment of adolescent idiopathic scoliosis,including 3D correction of deformity,posterior and minimally invasive surgery,and fusionless strategies.

  1. Tunable cavity resonator including a plurality of MEMS beams

    Energy Technology Data Exchange (ETDEWEB)

    Peroulis, Dimitrios; Fruehling, Adam; Small, Joshua Azariah; Liu, Xiaoguang; Irshad, Wasim; Arif, Muhammad Shoaib

    2015-10-20

    A tunable cavity resonator includes a substrate, a cap structure, and a tuning assembly. The cap structure extends from the substrate, and at least one of the substrate and the cap structure defines a resonator cavity. The tuning assembly is positioned at least partially within the resonator cavity. The tuning assembly includes a plurality of fixed-fixed MEMS beams configured for controllable movement relative to the substrate between an activated position and a deactivated position in order to tune a resonant frequency of the tunable cavity resonator.

  2. Simulations of Sisyphus cooling including multiple excited states

    CERN Document Server

    Svensson, F; Dion, C M

    2008-01-01

    We extend the theory for laser cooling in a near-resonant optical lattice to include multiple excited hyperfine states. Simulations are performed treating the external degrees of freedom of the atom, i.e., position and momentum, classically, while the internal atomic states are treated quantum mechanically, allowing for arbitrary superpositions. Whereas theoretical treatments including only a single excited hyperfine state predict that the temperature should be a function of lattice depth only, except close to resonance, experiments have shown that the minimum temperature achieved depends also on the detuning from resonance of the lattice light. Our results resolve this discrepancy.

  3. Methods of producing adsorption media including a metal oxide

    Science.gov (United States)

    Mann, Nicholas R; Tranter, Troy J

    2014-03-04

    Methods of producing a metal oxide are disclosed. The method comprises dissolving a metal salt in a reaction solvent to form a metal salt/reaction solvent solution. The metal salt is converted to a metal oxide and a caustic solution is added to the metal oxide/reaction solvent solution to adjust the pH of the metal oxide/reaction solvent solution to less than approximately 7.0. The metal oxide is precipitated and recovered. A method of producing adsorption media including the metal oxide is also disclosed, as is a precursor of an active component including particles of a metal oxide.

  4. Solar Energy Education. Renewable energy: a background text. [Includes glossary

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    Some of the most common forms of renewable energy are presented in this textbook for students. The topics include solar energy, wind power hydroelectric power, biomass ocean thermal energy, and tidal and geothermal energy. The main emphasis of the text is on the sun and the solar energy that it yields. Discussions on the sun's composition and the relationship between the earth, sun and atmosphere are provided. Insolation, active and passive solar systems, and solar collectors are the subtopics included under solar energy. (BCS)

  5. The Future of Constitutionally Required Lesser Included Offenses

    Directory of Open Access Journals (Sweden)

    Michael H. Hoffheimer

    2006-04-01

    Full Text Available For over a generation courts have recognized that failing to instruct juries on lesser included offenses results in wrongful convictions. In Beck v. Alabama, the Supreme Court held that in capital cases juries must be instructed on the option of returning convictions of non-capital lesser included offenses. The Court explained that this right prevents juries from being forced to make all-or-nothing choices between guilt and innocence in cases where serious crimes have been committed and pressures to convict of some crime are great.

  6. Truck Drivers And Risk Of STDs Including HIV

    Directory of Open Access Journals (Sweden)

    Bansal R.K

    1995-01-01

    Full Text Available Research Question: Whether long distance truck drivers are at a higher risk of contracting and transmitting STDs including HIV? Objectives: i To study the degree of knowledge of HIV and AIDS among long- distance truck drivers. ii Assess their sexual behaviour including condom use. iii Explore their prevailing social influences and substance abuse patterns. iv Explore their treatment seeking bahaviour as regards STDs. v Deduce their risk of contracting and transmitting STDs including HIV. Study Design: Cross- sectional interview. Setting: Transport Nagar, Indore (M.P Participants: 210 senior drivers (First drivers and 210 junior drivers (Second drivers. Study Variables: Extra-Marital sexual intercourse, condom usage, past and present history of STDs, treatment and counseling, substance abuse, social â€" cultural milieu. Outcome Variables: Risk of contraction of STDs. Statistical Analysis: Univariate analysis. Results: 94% of the drivers were totally ignorant about AIDS. 82.9% and 43.8 % of the senior and junior drivers had a history of extra- marital sex and of these only 2 regularly used condoms. 13.8% and 3.3 % of the senior and junior drivers had a past or present history suggestive of STD infection. Alcohol and Opium were regularly used by them. Conclusion: The studied drivers are at a high risk of contracting and transmitting STDs including HIV.

  7. Smart Antenna Skins, including Conformal Array, MMICs and Applications

    NARCIS (Netherlands)

    Bogaart, F.L.M. van den

    2000-01-01

    Low-cost technologies are presented for future space-borne and airborne SAR systems. These technologies include state-of-the art highly integrated circuits to miniaturise front-end, solutions to lower-cost interconnection technologies, new beamforming aspects and new architectures. The MMICs address

  8. Theory of nanorod antenna resonances including end-reflection phase

    Science.gov (United States)

    Su, Wei; Li, Xiangyin; Bornemann, Jens; Gordon, Reuven

    2015-04-01

    We present a fully analytic theory for nanorod resonances including the phase of reflection from the rounded ends using a transmission line approach. It combines the circuit theory response of spherical nanoparticles with standard transmission line theory using the Sommerfeld wave dispersion. The approach agrees well with comprehensive numerical calculations.

  9. A Reactive Behavior Agent: Including Emotions into a Video Game

    Directory of Open Access Journals (Sweden)

    A. L. Laureano-Cruces

    2012-10-01

    Full Text Available Why we have emotions and how they influence human behavior are two questions we constantly ask ourselves.According to researchers in the field, there are two kinds of information that the person receives to make a decision.This information is integrated to generate a whole. One comes from ourselves it is proprioceptive and refers toemotions; the other one is external, it comes from the environment. Thus, emotions are immersed in different areas ofa person’s life, including social, functional, and cognitive aspects. It has an important role in the decision-makingprocess. It is on this last point that this paper focuses its approach, which consists of including a cognitive structure ofemotions in a reactive behavior in order to enrich behavior, including the information generated through internalevaluation of the external physical stimuli. Our work is based on the OCC theory (named after the name of its authors:Ortony, Collins and Clore. This theory proposes that a decision-making process is affected through differentperspectives: a goals and events, b agents and their actions, and c objects and their capacity for attraction. Thecase study is situated within a scenario that represents an approach that seeks to include a module of emotions withinthe design of the architecture of a videogame.

  10. Prototype solar heating and cooling systems including potable hot water

    Science.gov (United States)

    1978-01-01

    Progress is reviewed in the development, delivery, and support of two prototype solar heating and cooling systems including potable hot water. The system consisted of the following subsystems: collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition.

  11. Novel model for wine fermentation including the yeast dying phase

    OpenAIRE

    Borzì, Alfio; Merger, Juri; Müller, Jonas; Rosch, Achim; Schenk, Christina; Schmidt, Dominik; Schmidt, Stephan; Schulz, Volker; Velten, Kai; von Wallbrunn, Christian; Zänglein, Michael

    2014-01-01

    This paper presents a novel model for wine fermentation including a death phase for yeast and the influence of oxygen on the process. A model for the inclusion of the yeast dying phase is derived and compared to a model taken from the literature. The modeling ability of the several models is analyzed by comparing their simulation results.

  12. Including Religion in American History: Some Notes on Student Resistance.

    Science.gov (United States)

    Talbert, Kevin M.; Romanowski, Michael H.

    2002-01-01

    Focuses on the importance of teaching religion in U.S. history courses. Discusses problems that teachers encounter when teaching religion, addresses the issue of students resisting learning about religion in the history classroom, and explores how teachers can reduce this resistance. Includes references. (CMK)

  13. Understanding heat transfer in 2D channel flows including recirculation

    NARCIS (Netherlands)

    Dirkse, M.H.; Loon, van W.K.P.; Stigter, J.D.; Bot, G.P.A.

    2007-01-01

    Inviscid, irrotational two-dimensional flows can be modelled using the Schwarz¿Christoffel integral. Although bounded flows including boundary layer separation and recirculation are not irrotational, a model is presented that uses the Schwarz¿Christoffel integral to model these flows. The model sepa

  14. Everglades National Park Including Biscayne National Park. Activity Book.

    Science.gov (United States)

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  15. Assessing the Doctoral Thesis When It Includes Published Work

    Science.gov (United States)

    Sharmini, Sharon; Spronken-Smith, Rachel; Golding, Clinton; Harland, Tony

    2015-01-01

    In this article we explore how examiners assess a thesis that includes published work. An online survey was used to gather data on approaches to assessing publication-based theses (PBTs). The respondents were 62 supervisors who had experience examining PBTs across a range of disciplines at a research-intensive university in New Zealand. Nearly…

  16. Modeling Electric Double-Layers Including Chemical Reaction Effects

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.;

    2014-01-01

    A physicochemical and numerical model for the transient formation of an electric double-layer between an electrolyte and a chemically-active flat surface is presented, based on a finite elements integration of the nonlinear Nernst-Planck-Poisson model including chemical reactions. The model works...

  17. Interviewing Objects: Including Educational Technologies as Qualitative Research Participants

    Science.gov (United States)

    Adams, Catherine A.; Thompson, Terrie Lynn

    2011-01-01

    This article argues the importance of including significant technologies-in-use as key qualitative research participants when studying today's digitally enhanced learning environments. We gather a set of eight heuristics to assist qualitative researchers in "interviewing" technologies-in-use (or other relevant objects), drawing on concrete…

  18. PREPARATION OF IODINE-INCLUDED CARBON USING RF PLASMA CVD

    Institute of Scientific and Technical Information of China (English)

    Y. Sakamoto; M. Takaya; T. Uchiyama

    2005-01-01

    For the aim of synthesis of the carbon-iodine compound, the preparation of iodine-included carbon using RF plasma CVD was studied. Iodine-included carbon was synthesized on Si substrate using ICP type RF plasma CVD apparatus. C2H5OH and I2 dissolved C2H5OH was used as reactant gases. As a result, surface morphologies of Iodine included carbon films showed fiat surfaces for each samples. On the structure of films estimated by Raman spectroscopy, amorphous carbon was recognized. And I2 peaks were observed in XPS spectra. As a result of friction test,friction coefficient of the sample growth with C2H5OH showed about 0.45. On the other hand,that of the sample with I2-C2H5OH showed about 0.3 and decrease of friction coefficient was recognized. Iodine inclusion for carbon materials can be achieved by RF plasma CVD using an I2-C2H5OH reactant. The coefficient of iodine-included carbon showed lower than of without iodine

  19. Computer aided design of reentrant coaxial filters including coaxial excitation

    NARCIS (Netherlands)

    Boria, V.; Gerini, G.; Guglielmi, M.

    1999-01-01

    An advanced EM based CAD tool is used for the detailed characterisation of a family of reentrant coaxial waveguide filters. The EM analysis includes the effects of tuning screws and of the input/output coaxial excitation. The software is essentially used as an efficient replacement for the tradition

  20. /facet: A Generic Facet Browser Including Temporal and Spatial Visualization

    NARCIS (Netherlands)

    Hildebrand, M.

    2007-01-01

    A generic facet browser including temporal and spatial visualization. The existing MultimediaN Eculture demo is updated in two ways: improved visualization of the semantic timeline and added a natural language sentence generator for cluster headers. Relation search interface is also implemente

  1. Post-Polio Health International including International Ventilator Users Network

    Science.gov (United States)

    ... pm CT, Monday-Friday) ; 314-534-5070 fax info@post-polio.org (Inquiries should include name and mailing address.) www.post-polio.org | www.polioplace.org Like us on Facebook. @polioplace Link to PHI's affiliate ... International Ventilator Users Network (IVUN) ©Copyright Post-Polio Health International

  2. Prototype solar heating and cooling systems including potable hot water

    Science.gov (United States)

    1978-01-01

    These combined quarterly reports summarize the activities from November 1977 through September 1978, and over the progress made in the development, delivery and support of two prototype solar heating and cooling systems including potable hot water. The system consists of the following subsystems: solar collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition.

  3. LTRACK: Beam-transport calculation including wakefield effects

    International Nuclear Information System (INIS)

    LTRACK is a first-order beam-transport code that includes wakefield effects up to quadrupole modes. This paper will introduce the readers to this computer code by describing the history, the method of calculations, and a brief summary of the input/output information. Future plans for the code will also be described

  4. Testing Intelligently Includes Double-Checking Wechsler IQ Scores

    Science.gov (United States)

    Kuentzel, Jeffrey G.; Hetterscheidt, Lesley A.; Barnett, Douglas

    2011-01-01

    The rigors of standardized testing make for numerous opportunities for examiner error, including simple computational mistakes in scoring. Although experts recommend that test scoring be double-checked, the extent to which independent double-checking would reduce scoring errors is not known. A double-checking procedure was established at a…

  5. Including Parents in School Governance: Rhetoric or Reality

    Science.gov (United States)

    Ng, Shun Wing

    2013-01-01

    Purpose: The purpose of this paper is to report a qualitative study exploring how parents have been included in school governance in Hong Kong and in what ways their roles have been evolving in state education. Design/methodology/approach: The qualitative method was adopted in this exploratory study, the findings of which help provide insights for…

  6. The Physics of Semiconductors An Introduction Including Devices and Nanophysics

    CERN Document Server

    Grundmann, Marius

    2006-01-01

    The Physics of Semiconductors provides material for a comprehensive upper-level-undergrauate and graduate course on the subject, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. For the interested reader some additional advanced topics are included, such as Bragg mirrors, resonators, polarized and magnetic semiconductors are included. Also supplied are explicit formulas for many results, to support better understanding. The Physics of Semiconductors requires little or no prior knowledge of solid-state physics and evolved from ...

  7. Improving the strength of amalgams by including steel fibers

    International Nuclear Information System (INIS)

    Highlights: ► A room temperature liquid Ga–In alloy was successfully substituted for mercury. ► Physically sound amalgams with included steel fibers can be made. ► A small volume fraction inclusion of fibers increased strength by ∼20%. - Abstract: Mercury amalgams, due to their material properties, are widely and successfully used in dental practice. They are, however, also well recognized as having poor tensile strength. With the possibility of expanding amalgam applications it is demonstrated that tensile strength can be increased some 20% by including a small amount of steel fibers. Furthermore, it is shown that mercury can be replaced with a room temperature liquid gallium–indium alloy. Processing, microstructures, and mechanical test results of these novel amalgams are presented and discussed in view of means to further improve their properties.

  8. Microfluidic System Simulation Including the Electro-Viscous Effect

    Science.gov (United States)

    Rojas, Eileen; Chen, C. P.; Majumdar, Alok

    2007-01-01

    This paper describes a practical approach using a general purpose lumped-parameter computer program, GFSSP (Generalized Fluid System Simulation Program) for calculating flow distribution in a network of micro-channels including electro-viscous effects due to the existence of electrical double layer (EDL). In this study, an empirical formulation for calculating an effective viscosity of ionic solutions based on dimensional analysis is described to account for surface charge and bulk fluid conductivity, which give rise to electro-viscous effect in microfluidics network. Two dimensional slit micro flow data was used to determine the model coefficients. Geometry effect is then included through a Poiseuille number correlation in GFSSP. The bi-power model was used to calculate flow distribution of isotropically etched straight channel and T-junction microflows involving ionic solutions. Performance of the proposed model is assessed against experimental test data.

  9. XFEL OSCILLATOR SIMULATION INCLUDING ANGLE-DEPENDENT CRYSTAL REFLECTIVITY

    Energy Technology Data Exchange (ETDEWEB)

    Fawley, William; Lindberg, Ryan; Kim, K-J; Shvyd' ko, Yuri

    2010-08-23

    The oscillator package within the GINGER FEL simulation code has now been extended to include angle-dependent reflectivity properties of Bragg crystals. Previously, the package was modified to include frequencydependent reflectivity in order to model x-ray FEL oscillators from start-up from shot noise through to saturation. We present a summary of the algorithms used for modeling the crystal reflectivity and radiation propagation outside the undulator, discussing various numerical issues relevant to the domain of high Fresnel number and efficient Hankel transforms. We give some sample XFEL-O simulation results obtained with the angle-dependent reflectivity model, with particular attention directed to the longitudinal and transverse coherence of the radiation output.

  10. Topology of dynamical lattice configurations including results from overlap fermions

    CERN Document Server

    Bruckmann, Falk; Gruber, Florian; Lippert, Thomas; Schäfer, Andreas

    2011-01-01

    We investigate how the topological charge density in lattice QCD simulations is affected by violations of chiral symmetry caused by the fermion action. To this end we compare lattice configurations generated with a number of different actions including first configurations generated with exact overlap quarks. We visualize the topological profiles after mild smearing. In the topological charge correlator we measure the size of the positive core, which is known to vanish in the continuum limit. To leading order we find the core size to scale linearly with the lattice spacing with the same coefficient for all actions, even including quenched simulations. In the subleading term the different actions vary over a range of about 10%. Our findings suggest that non-chiral lattice actions at current lattice spacings do not differ much for observables related to topology, both among themselves and compared to overlap fermions.

  11. Including investment risk in large-scale power market models

    DEFF Research Database (Denmark)

    Lemming, Jørgen Kjærgaard; Meibom, P.

    2003-01-01

    the analyses quantitatively, a framework based on an iterative interaction between the equilibrium model and a separate risk-adjustment module was constructed. To illustrate the features of the proposed modelling approach we examined how uncertainty in demand and variable costs affects the optimal choice......Long-term energy market models can be used to examine investments in production technologies, however, with market liberalisation it is crucial that such models include investment risks and investor behaviour. This paper analyses how the effect of investment risk on production technology selection...... can be included in large-scale partial equilibrium models of the power market. The analyses are divided into a part about risk measures appropriate for power market investors and a more technical part about the combination of a risk-adjustment model and a partial-equilibrium model. To illustrate...

  12. Improving the strength of amalgams by including steel fibers

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, Calvin T. [Hendrix College, Conway, AR 72032 (United States); Van Hoose, James R. [Siemens, Orlando, FL 32826 (United States); McGill, Preston B. [Marshall Space Flight Center, EM20, Huntsville, AL 35812 (United States); Grugel, Richard N., E-mail: richard.n.grugel@nasa.gov [Marshall Space Flight Center, EM30, Huntsville, AL 35812 (United States)

    2012-05-30

    Highlights: Black-Right-Pointing-Pointer A room temperature liquid Ga-In alloy was successfully substituted for mercury. Black-Right-Pointing-Pointer Physically sound amalgams with included steel fibers can be made. Black-Right-Pointing-Pointer A small volume fraction inclusion of fibers increased strength by {approx}20%. - Abstract: Mercury amalgams, due to their material properties, are widely and successfully used in dental practice. They are, however, also well recognized as having poor tensile strength. With the possibility of expanding amalgam applications it is demonstrated that tensile strength can be increased some 20% by including a small amount of steel fibers. Furthermore, it is shown that mercury can be replaced with a room temperature liquid gallium-indium alloy. Processing, microstructures, and mechanical test results of these novel amalgams are presented and discussed in view of means to further improve their properties.

  13. Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function

    Directory of Open Access Journals (Sweden)

    Simon N. Dankel

    2011-01-01

    Full Text Available A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders.

  14. Management of radioactive waste from reprocessing including disposal aspects

    International Nuclear Information System (INIS)

    Based on a hypothetical scenario including a reactor park of 20 GWe consisting of Pressurised-Water-Reactors with a resulting annual production of 600 tonnes of heavy metal of spent fuel, all aspects of management of resulting wastes are studied. Waste streams from reprocessing include gaseous and liquid effluents, and a number of solid conditioned waste types. Disposal of waste is supposed to be performed either in a near-surface engineered repository, as long as the content of alpha-emitting radionuclides is low enough, and in a deep geological granite formation. After having estimated quantities, cost and radiological consequences, the sensitivity of results to modification in reactor park size, burn-up and the introduction of mixed-oxide fuel (MOX) is evaluated

  15. Should LSP Dictionaries. also Include Professional Jargon and Slang?

    OpenAIRE

    Rosemarie Gläser

    2011-01-01

    Abstract: The paper discusses the question whether an LSP dictionary should take the sociolinguistic stratification of the entire speech community in a particular domain of activity into consideration, and as a consequence, also encompass vocabulary on the lower stylistic levels, such as professional jargon and occupational slang in addition to technical terminology and nomenclature. The author's contention is that by including such vocabulary, an LSP dictionary will be more comprehe...

  16. Towards a general framework for including noise impacts in LCA

    OpenAIRE

    Cucurachi, Stefano; Heijungs, Reinout; Ohlau, Katrin

    2012-01-01

    Purpose Several damages have been associated with the exposure of human beings to noise. These include auditory effects, i.e., hearing impairment, but also non-auditory physiological ones such as hypertension and ischemic heart disease, or psychological ones such as annoyance, depression, sleep disturbance, limited performance of cognitive tasks or inadequate cognitive development. Noise can also interfere with intended activities, both in daytime and nighttime. ISO 14'040 also indicated the ...

  17. Optimization of pipe networks including pumps by simulated annealing

    OpenAIRE

    Costa A.L.H.; Medeiros J.L.; Pessoa F.L.P.

    2000-01-01

    The objective of this work is to present an application of the simulated annealing method for the optimal design of pipe networks including pumps. Although its importance, the optimization of pumped networks did not receive great attention in the literature. The proposed search scheme explores the discrete space of the decision variables: pipe diameters and pump sizes. The behavior of the pumps is describe through the characteristic curve, generating more realistic solutions. In order to demo...

  18. Evaporative cooler including one or more rotating cooler louvers

    Energy Technology Data Exchange (ETDEWEB)

    Gerlach, David W

    2015-02-03

    An evaporative cooler may include an evaporative cooler housing with a duct extending therethrough, a plurality of cooler louvers with respective porous evaporative cooler pads, and a working fluid source conduit. The cooler louvers are arranged within the duct and rotatably connected to the cooler housing along respective louver axes. The source conduit provides an evaporative cooler working fluid to the cooler pads during at least one mode of operation.

  19. Chiral-scale effective theory including a dilatonic meson

    CERN Document Server

    Li, Yan-Ling; Rho, Mannque

    2016-01-01

    A scale-invariant chiral effective Lagrangian is constructed for octet pions and a dilaton figuring as Nambu-Goldstone bosons with vector mesons incorporated as hidden gauge fields. The Lagrangian is built to the next-to-leading order in chiral-scale counting without baryon fields and then to leading order including baryons. The resulting theory is hidden scale-symmetric and local symmetric. We also discuss some possible applications of the present Lagrangian.

  20. DILIGENT - Preliminary training plan (includes training support environment) - M9

    OpenAIRE

    Castelli, Donatella; Manieri, Andrea; Stein, Adeheit; Niederee, Claudia; Schek, Hans-J?rg; Schuldt, Heiko

    2005-01-01

    This report presents the plans for the DILIGENT intra-project, inter-project and external training activities. It describes the initial strategic and operational plans for each of these types of training (D4.1.2). The report includes a textual description of the training support environment (D4.1.1). For the intra-project training which started at Month 6, it also reports some of the already completed activities.

  1. Stochastic modelling of two-phase flows including phase change

    International Nuclear Information System (INIS)

    Stochastic modelling has already been developed and applied for single-phase flows and incompressible two-phase flows. In this article, we propose an extension of this modelling approach to two-phase flows including phase change (e.g. for steam-water flows). Two aspects are emphasised: a stochastic model accounting for phase transition and a modelling constraint which arises from volume conservation. To illustrate the whole approach, some remarks are eventually proposed for two-fluid models. (authors)

  2. Compendium of practices for including children in family sessions

    OpenAIRE

    Carr, Alan.

    2002-01-01

    The approach to involving children in family counselling described here is based on three principles. First, at an ethical level children have a right to participate in the process of solving problems of living which they and their families face. Second, at a pragmatic level counselling has a better chance of success if those involved in the problem, including children, participate in the solution. Third, at a theoretical level, methods of engaging children in counselling must be based on an ...

  3. Production, control and utilization of radioisotopes including radiopharmaceuticals

    International Nuclear Information System (INIS)

    From April 29th to May 5th, 1984 27 participants from 21 developing countries stayed within an IAEA Study Tour ('Production, Control and Utilization of Radioisotopes including Radiopharmaceuticals') in the GDR. In the CINR, Rossendorf the reactor, the cyclotron, the technological centre as well as the animal test laboratory were visited. The participants were made familiar by 10 papers with the development, production and control of radiopharmaceuticals in the CINR, Rossendorf. (author)

  4. Modeling heart rate variability including the effect of sleep stages

    Science.gov (United States)

    Soliński, Mateusz; Gierałtowski, Jan; Żebrowski, Jan

    2016-02-01

    We propose a model for heart rate variability (HRV) of a healthy individual during sleep with the assumption that the heart rate variability is predominantly a random process. Autonomic nervous system activity has different properties during different sleep stages, and this affects many physiological systems including the cardiovascular system. Different properties of HRV can be observed during each particular sleep stage. We believe that taking into account the sleep architecture is crucial for modeling the human nighttime HRV. The stochastic model of HRV introduced by Kantelhardt et al. was used as the initial starting point. We studied the statistical properties of sleep in healthy adults, analyzing 30 polysomnographic recordings, which provided realistic information about sleep architecture. Next, we generated synthetic hypnograms and included them in the modeling of nighttime RR interval series. The results of standard HRV linear analysis and of nonlinear analysis (Shannon entropy, Poincaré plots, and multiscale multifractal analysis) show that—in comparison with real data—the HRV signals obtained from our model have very similar properties, in particular including the multifractal characteristics at different time scales. The model described in this paper is discussed in the context of normal sleep. However, its construction is such that it should allow to model heart rate variability in sleep disorders. This possibility is briefly discussed.

  5. Transport Phenomena in Thin Rotating Liquid Films Including: Nucleate Boiling

    Science.gov (United States)

    Faghri, Amir

    2005-01-01

    In this grant, experimental, numerical and analytical studies of heat transfer in a thin liquid film flowing over a rotating disk have been conducted. Heat transfer coefficients were measured experimentally in a rotating disk heat transfer apparatus where the disk was heated from below with electrical resistance heaters. The heat transfer measurements were supplemented by experimental characterization of the liquid film thickness using a novel laser based technique. The heat transfer measurements show that the disk rotation plays an important role on enhancement of heat transfer primarily through the thinning of the liquid film. Experiments covered both momentum and rotation dominated regimes of the flow and heat transfer in this apparatus. Heat transfer measurements have been extended to include evaporation and nucleate boiling and these experiments are continuing in our laboratory. Empirical correlations have also been developed to provide useful information for design of compact high efficiency heat transfer devices. The experimental work has been supplemented by numerical and analytical analyses of the same problem. Both numerical and analytical results have been found to agree reasonably well with the experimental results on liquid film thickness and heat transfer Coefficients/Nusselt numbers. The numerical simulations include the free surface liquid film flow and heat transfer under disk rotation including the conjugate effects. The analytical analysis utilizes an integral boundary layer approach from which

  6. The COG database: an updated version includes eukaryotes

    Directory of Open Access Journals (Sweden)

    Sverdlov Alexander V

    2003-09-01

    Full Text Available Abstract Background The availability of multiple, essentially complete genome sequences of prokaryotes and eukaryotes spurred both the demand and the opportunity for the construction of an evolutionary classification of genes from these genomes. Such a classification system based on orthologous relationships between genes appears to be a natural framework for comparative genomics and should facilitate both functional annotation of genomes and large-scale evolutionary studies. Results We describe here a major update of the previously developed system for delineation of Clusters of Orthologous Groups of proteins (COGs from the sequenced genomes of prokaryotes and unicellular eukaryotes and the construction of clusters of predicted orthologs for 7 eukaryotic genomes, which we named KOGs after eukaryotic orthologous groups. The COG collection currently consists of 138,458 proteins, which form 4873 COGs and comprise 75% of the 185,505 (predicted proteins encoded in 66 genomes of unicellular organisms. The eukaryotic orthologous groups (KOGs include proteins from 7 eukaryotic genomes: three animals (the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and Homo sapiens, one plant, Arabidopsis thaliana, two fungi (Saccharomyces cerevisiae and Schizosaccharomyces pombe, and the intracellular microsporidian parasite Encephalitozoon cuniculi. The current KOG set consists of 4852 clusters of orthologs, which include 59,838 proteins, or ~54% of the analyzed eukaryotic 110,655 gene products. Compared to the coverage of the prokaryotic genomes with COGs, a considerably smaller fraction of eukaryotic genes could be included into the KOGs; addition of new eukaryotic genomes is expected to result in substantial increase in the coverage of eukaryotic genomes with KOGs. Examination of the phyletic patterns of KOGs reveals a conserved core represented in all analyzed species and consisting of ~20% of the KOG set. This conserved portion of the

  7. 77 FR 9969 - Clow Water Systems Company Including On-Site Leased Workers From Carol Harris Stafffing Including...

    Science.gov (United States)

    2012-02-21

    ... on December 29, 2011(76 FR 81988). At the request of the State agency, the Department reviewed the... Employment and Training Administration Clow Water Systems Company Including On-Site Leased Workers From Carol... leased workers from Carol Harris Staffing, Coshocton, Ohio. The workers are engaged in activities...

  8. Composite armor, armor system and vehicle including armor system

    Science.gov (United States)

    Chu, Henry S.; Jones, Warren F.; Lacy, Jeffrey M.; Thinnes, Gary L.

    2013-01-01

    Composite armor panels are disclosed. Each panel comprises a plurality of functional layers comprising at least an outermost layer, an intermediate layer and a base layer. An armor system incorporating armor panels is also disclosed. Armor panels are mounted on carriages movably secured to adjacent rails of a rail system. Each panel may be moved on its associated rail and into partially overlapping relationship with another panel on an adjacent rail for protection against incoming ordnance from various directions. The rail system may be configured as at least a part of a ring, and be disposed about a hatch on a vehicle. Vehicles including an armor system are also disclosed.

  9. Extended 1D Method for Coherent Synchrotron Radiation including Shielding

    CERN Document Server

    Sagan, David; Mayes, Christopher; Sae-Ueng, Udom

    2008-01-01

    Coherent Synchrotron Radiation can severely limit the performance of accelerators designed for high brightness and short bunch length. Examples include light sources based on ERLs or FELs, and bunch compressors for linear colliders. In order to better simulate Coherent Synchrotron Radiation, the established 1-dimensional formalism is extended to work at lower energies, at shorter bunch lengths, and for an arbitrary configuration of multiple bends. Wide vacuum chambers are simulated by means of vertical image charges. This formalism has been implemented in the general beam dynamics code "Bmad" and its results are here compared to analytical approximations, to numerical solutions of the Maxwell equations, and to the simulation code "elegant".

  10. The action principle for generalized fluid motion including gyroviscosity

    Science.gov (United States)

    Lingam, M.; Morrison, P. J.

    2014-11-01

    A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  11. The action principle for generalized fluid motion including gyroviscosity

    CERN Document Server

    Lingam, M

    2014-01-01

    A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  12. Collective Atomic Recoil Lasing Including Friction and Diffusion Effects

    CERN Document Server

    Robb, G R M; Ferraro, A; Bonifacio, R; Courteille, P W; Zimmermann, C; Courteille, Ph.W.

    2003-01-01

    We extend the Collective Atomic Recoil Lasing (CARL) model including the effects of friction and diffusion forces acting on the atoms due to the presence of optical molasses fields. The results from this model are consistent with those from a recent experiment by Kruse et al. [Phys. Rev. Lett. 91, 183601 (2003)]. In particular, we obtain a threshold condition above which collective backscattering occurs. Using a nonlinear analysis we show that the backscattered field and the bunching evolve to a steady-state, in contrast to the non-stationary behaviour of the standard CARL model. For a proper choice of the parameters, this steady-state can be superfluorescent.

  13. Methodological challenges when doing research that includes ethnic minorities

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2016-01-01

    minorities are included. Method: A thorough literature search yielded 21 articles obtained from the scientific databases PubMed, Cinahl, Web of Science and PsychInfo. Analysis followed Arksey and O’Malley’s framework for scoping reviews, applying content analysis. Results: The results showed methodological......Background: There are challenging methodological issues in obtaining valid and reliable results on which to base occupational therapy interventions for ethnic minorities. The aim of this scoping review is to describe the methodological problems within occupational therapy research, when ethnic...

  14. Cont-Bouchaud Percolation Model Including Tobin Tax

    Science.gov (United States)

    Ehrenstein, Gudrun

    The Tobin tax is an often discussed method to tame speculation and get a source of income. The discussion is especially heated when the financial markets are in crisis. In this article we refer to the foreign exchange markets. The Tobin tax should be a small international tax affecting all currency transactions and thus consequently reducing destabilizing speculations. In this way this tax should take over a control function. By including the Tobin tax in the microscopic model of Cont and Bouchaud one finds that this tax could be the right method to control foreign exchange operations and to get a good source of income.

  15. Visió general de la discussió sobre les àrees d’exclusió del projecte INCLUD-ED General overview of the discussion on exclusion areas in the INCLUD-ED project Visión general de la discusión sobre las áreas de exclusión del proyecto INCLUD-ED

    OpenAIRE

    Carme García; Itxaso Tellado; Tiziana Chiappelli

    2010-01-01

    En aquest article es discuteixen les aportacions que es fan des del projecte INCLUD-ED: Strategies for inclusion and social cohesion from education in Europe sobre la relació que es pot establir entre l’exclusió/inclusió educativa i l’exclusió/inclusió en quatre àrees de la societat: ocupació, habitatge, salut i participació social i política. En particular, es reflexiona sobre els efectes que té tant l’exclusió, com formes de superar-la i promoure la inclusió, en les situacions que han d’afr...

  16. APORTACIONES DE LA INVESTIGACIÓN EUROPEA INCLUD-ED PARA LA REDUCCIÓN DEL ABANDONO ESCOLAR PREMATURO

    Directory of Open Access Journals (Sweden)

    Maria Padrós Cuxart

    2011-05-01

    Full Text Available The challenge of reducing early school leaving in Europe, with special pressure in Spain, leads to the need of evidence based educational policies and measures. This paper presents measures to prevend and reduce early school leaving that have been identified within the research Project INCLUD-ED. Strategies for inclusion and social cohesion in Europe from education. This is the research Project with a higher level and resources developed  since now  in Europe regarding school education. The identified solutions are already being addressed in documents of the European Commission, such as the recent Communication to the European Parliament "Tackiling early school leaving: a key contribution to the Europe 2020 Agenda".

  17. Evaluation of FEMA-440 for including soil-structure interaction

    Institute of Scientific and Technical Information of China (English)

    Khoshnoudian F.; Behmanesh I.

    2010-01-01

    Replacing the entire soil-structure system with a fixed base oscillator to consider the effect of soil-structure interaction (SSI) is a common analysis method in seismic design. This technique has been included in design procedures such as NEHRP, ASCE, etc. By defining an equivalent fundamental period and damping ratio that can modify the response of the structure. However, recent studies indicate that the effects of SSI should be reconsidered when a structure undergoes a nonlinear displacement demand. In recent documents on Nonlinear Static Procedures (NSPs), FEMA-440 (2005), a modified damping ratio of the replacement oscillator was proposed by introducing the ductility of the soil-structure system obtained from pushover analysis. In this paper, the damping defined in FEMA-440 to include the soil-structure interaction effect is evaluated, and the accuracy of the Coefficiem Method given in FEMA-440 and the Equivalent Linearization Method is studied. Although the improvements for Nonlinear Static Procedures (NSPs) in FEMA-440 are achieved for a fixed base SDOF structure, the soil effects are not perfectly obtained. Furthermore, the damping definition of a soil-structure system is extended to structures to consider bilinear behavior.

  18. Chemical Compatibility Testing Final Report Including Test Plans and Procedures

    International Nuclear Information System (INIS)

    This report provides an independent assessment of information on mixed waste streams, chemical compatibility information on polymers, and standard test methods for polymer properties. It includes a technology review of mixed low-level waste (LLW) streams and material compatibilities, validation for the plan to test the compatibility of simulated mixed wastes with potential seal and liner materials, and the test plan itself. Potential packaging materials were reviewed and evaluated for compatibility with expected hazardous wastes. The chemical and physical property measurements required for testing container materials were determined. Test methodologies for evaluating compatibility were collected and reviewed for applicability. A test plan to meet US Department of Energy and Environmental Protection Agency requirements was developed. The expected wastes were compared with the chemical resistances of polymers, the top-ranking polymers were selected for testing, and the most applicable test methods for candidate seal and liner materials were determined. Five recommended solutions to simulate mixed LLW streams are described. The test plan includes descriptions of test materials, test procedures, data collection protocols, safety and environmental considerations, and quality assurance procedures. The recommended order of testing to be conducted is specified

  19. Generalized fluid theory including non-Maxwellian kinetic effects

    CERN Document Server

    Izacard, Olivier

    2016-01-01

    The results obtained by the plasma physics community for the validation and the prediction of turbulence and transport in magnetized plasma come mainly from the use of very CPU-consuming particle-in-cell or (gyro)kinetic codes which naturally include non-Maxwellian kinetic effects. To date, fluid codes are not considered to be relevant for the description of these kinetic effects. Here, after revisiting the limitations of the current fluid theory developed in the 19th century, we generalize the fluid theory including kinetic effects such as non-Maxwellian super-thermal tails with as few fluid equations as possible. The collisionless and collisional fluid closures from the nonlinear Landau Fokker-Planck collision operator are shown for an arbitrary collisionality. Indeed, the first fluid models associated with two examples of collisionless fluid closures are obtained by assuming an analytic non-Maxwellian distribution function (e.g., the INMDF [O. Izacard, Phys. Plasmas 23, 082504 (2016)]). One of the main dif...

  20. Constant-Pressure Combustion Charts Including Effects of Diluent Addition

    Science.gov (United States)

    Turner, L Richard; Bogart, Donald

    1949-01-01

    Charts are presented for the calculation of (a) the final temperatures and the temperature changes involved in constant-pressure combustion processes of air and in products of combustion of air and hydrocarbon fuels, and (b) the quantity of hydrocarbon fuels required in order to attain a specified combustion temperature when water, alcohol, water-alcohol mixtures, liquid ammonia, liquid carbon dioxide, liquid nitrogen, liquid oxygen, or their mixtures are added to air as diluents or refrigerants. The ideal combustion process and combustion with incomplete heat release from the primary fuel and from combustible diluents are considered. The effect of preheating the mixture of air and diluents and the effect of an initial water-vapor content in the combustion air on the required fuel quantity are also included. The charts are applicable only to processes in which the final mixture is leaner than stoichiometric and at temperatures where dissociation is unimportant. A chart is also included to permit the calculation of the stoichiometric ratio of hydrocarbon fuel to air with diluent addition. The use of the charts is illustrated by numerical examples.

  1. Community Assessment Tool for Public Health Emergencies Including Pandemic Influenza

    Energy Technology Data Exchange (ETDEWEB)

    ORAU' s Oak Ridge Institute for Science Education (HCTT-CHE)

    2011-04-14

    The Community Assessment Tool (CAT) for Public Health Emergencies Including Pandemic Influenza (hereafter referred to as the CAT) was developed as a result of feedback received from several communities. These communities participated in workshops focused on influenza pandemic planning and response. The 2008 through 2011 workshops were sponsored by the Centers for Disease Control and Prevention (CDC). Feedback during those workshops indicated the need for a tool that a community can use to assess its readiness for a disaster - readiness from a total healthcare perspective, not just hospitals, but the whole healthcare system. The CAT intends to do just that - help strengthen existing preparedness plans by allowing the healthcare system and other agencies to work together during an influenza pandemic. It helps reveal each core agency partners (sectors) capabilities and resources, and highlights cases of the same vendors being used for resource supplies (e.g., personal protective equipment [PPE] and oxygen) by the partners (e.g., public health departments, clinics, or hospitals). The CAT also addresses gaps in the community's capabilities or potential shortages in resources. This tool has been reviewed by a variety of key subject matter experts from federal, state, and local agencies and organizations. It also has been piloted with various communities that consist of different population sizes, to include large urban to small rural communities.

  2. Remote observations of reentering spacecraft including the space shuttle orbiter

    Science.gov (United States)

    Horvath, Thomas J.; Cagle, Melinda F.; Grinstead, Jay H.; Gibson, David M.

    Flight measurement is a critical phase in development, validation and certification processes of technologies destined for future civilian and military operational capabilities. This paper focuses on several recent NASA-sponsored remote observations that have provided unique engineering and scientific insights of reentry vehicle flight phenomenology and performance that could not necessarily be obtained with more traditional instrumentation methods such as onboard discrete surface sensors. The missions highlighted include multiple spatially-resolved infrared observations of the NASA Space Shuttle Orbiter during hypersonic reentry from 2009 to 2011, and emission spectroscopy of comparatively small-sized sample return capsules returning from exploration missions. Emphasis has been placed upon identifying the challenges associated with these remote sensing missions with focus on end-to-end aspects that include the initial science objective, selection of the appropriate imaging platform and instrumentation suite, target flight path analysis and acquisition strategy, pre-mission simulations to optimize sensor configuration, logistics and communications during the actual observation. Explored are collaborative opportunities and technology investments required to develop a next-generation quantitative imaging system (i.e., an intelligent sensor and platform) with greater capability, which could more affordably support cross cutting civilian and military flight test needs.

  3. Including International Aviation in the EU Emissions Trading Scheme

    Energy Technology Data Exchange (ETDEWEB)

    Kopsch, Fredrik

    2011-07-01

    Starting on January 1 st, 2012, the international aviation sector will be included into the already existing EU ETS. All air crafts departing and arriving within the European Union will be obliged to hold permits corresponding to their total emissions of CO{sub 2} for those routes. Since emissions from the international aviation sector are not included under the Kyoto Protocol, the European Commission has decided to introduce a trading barrier between the sectors in order not to jeopardize the Kyoto targets. The purpose of this paper is to analyse the potential loss in cost-effectiveness of introducing such a trading barrier between two sectors taking into account that damage from emissions is not necessarily uniform. A theoretical model is developed to address the question and it is found that, at least for the case with linking the international aviation sector to the stationary sources within the EU ETS, the trading barrier might be unwarranted as it might lead to higher damage from emissions as compared to alternative ways to link the trading sectors. However, it should be stressed that this finding is not general and caution should be taken in the future when linking emission trading schemes as, depending on the heterogeneity of emission damage, a trading barrier might very well be justified

  4. TOOLS TO INCLUDE BLIND STUDENTS IN SCHOOL BUILDING PERFORMANCE ASSESSMENTS

    Directory of Open Access Journals (Sweden)

    Tania Pietzschke Abate

    2016-05-01

    Full Text Available This article discusses the design of data collection instruments that include the opinions of blind students, in accordance with the principles of Universal Design (UD. The aim of this study is to understand the importance of adapting data collection instruments for the inclusion of disabled persons in field research in Architecture and Design, among other fields. The data collection instruments developed were a play interview with a tactile map and a 3D survey with the use of tactile models. These instruments sought to assess the school environment experienced by blind students. The study involved students from the early years of a school for the blind who had not yet mastered the Braille system. The participation of these students was evaluated. A multidisciplinary team consisting of architects, designers, educators, and psychologists lent support to the study. The results showed that the data collection instruments adapted to blind students were successful in making the group of authors examine questions regarding UD. An analysis of the participatory phase showed that the limitations resulting from blindness determine the specificities in the adaptation and implementation process of the instruments in schools. Practical recommendations for future studies related to instruments in the UD thematic are presented. This approach is in line with the global trend of including disabled persons in society based on these users’ opinions concerning what was designed by architects and designers.

  5. Kabuki syndrome: expanding the phenotype to include microphthalmia and anophthalmia.

    Science.gov (United States)

    McVeigh, Terri P; Banka, Siddharth; Reardon, William

    2015-10-01

    Kabuki syndrome is a rare genetic malformation syndrome that is characterized by distinct facies, structural defects and intellectual disability. Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A. We describe a male child of nonconsanguineous Irish parents presenting with multiple malformations, including bilateral extreme microphthalmia; cleft palate; congenital diaphragmatic hernia; duplex kidney; as well as facial features of Kabuki syndrome, including interrupted eyebrows and lower lid ectropion. A de-novo germline mutation in KMT2D was identified. Whole-exome sequencing failed to reveal mutations in any of the known microphthalmia/anopthalmia genes. We also identified four other patients with Kabuki syndrome and microphthalmia. We postulate that Kabuki syndrome may produce this type of ocular phenotype as a result of extensive interaction between KMT2D, WAR complex proteins and PAXIP1. Children presenting with microphthalmia/anophthalmia should be examined closely for other signs of Kabuki syndrome, especially at an age where the facial gestalt might be less readily appreciable.

  6. Mucosal Immunization with Helicobacter, CpG DNA, and Cholera Toxin Is Protective

    OpenAIRE

    Jiang, Weiwen; Baker, Henry J.; Smith, Bruce F.

    2003-01-01

    The mucosal delivery of antigens requires an effective adjuvant to induce mucosal immunity. Current mucosal adjuvants include cholera toxin (CT) and Escherichia coli heat-labile toxin. Unmethylated CpG immunostimulatory oligodeoxynucleotides (ODNs) have been proposed as novel mucosal adjuvants. In this study, mice were immunized with sonicated Helicobacter felis with CT and/or CpG ODN adjuvants. All groups receiving either adjuvant singly or in combination developed increased serum anti-H. fe...

  7. SIMS analysis of insulating multilayer including silicon nitride

    International Nuclear Information System (INIS)

    We developed a new sample preparation method for thick insulating samples in secondary ion mass spectrometry (SIMS) analyses. In power semiconductor devices, impurity analyses in passivation layers and sealing resins are very important. SIMS analyses are suitable for this purpose, but in SIMS analysis of insulating samples, charging up would be a serious problem. Previous methods are not efficient enough to avoid the charging up of thick insulating sample, such as passivation layers. In this new technique of sample preparation, we made trenches by a FIB Ga beam, and filled them up with Pt. Including these Pt lines into the raster area, the charge of the sample can flow away through these lines during SIMS analysis. We applied this method to SiN/Si samples and confirmed that embedded Pt lines were effective for preventing the charging up

  8. Modeling potentiometric measurements in topological insulators including parallel channels

    Science.gov (United States)

    Hong, Seokmin; Diep, Vinh; Datta, Supriyo; Chen, Yong P.

    2012-08-01

    The discovery of spin-polarized states at the surface of three-dimensional topological insulators (TI) like Bi2Te3 and Bi2Se3 motivates intense interests in possible electrical measurements demonstrating unique signatures of these unusual states. Here we show that a three-terminal potentiometric set-up can be used to probe them by measuring the voltage change of a detecting magnet upon reversing its magnetization. We present numerical results using a nonequilibrium Green's function (NEGF)-based model to show the corresponding signal quantitatively in various transport regimes. We then provide an analytical expression for the resistance (the measured voltage difference divided by an applied current) that agrees with NEGF results well in both ballistic and diffusive limits. This expression is applicable to TI surface states, two-dimensional electrons with Rashba spin-split bands, and any combination of multiple channels, including bulk parallel states in TI, which makes it useful in analyzing experimental results.

  9. Extensions of MAD Version 8 to Include Beam Acceleration

    International Nuclear Information System (INIS)

    In this paper, the authors describe modifications to MAD version 8.23 to include linear accelerator cavities and beam acceleration. An additional energy variable has been added which is modified as the beam passes through LCAV elements (linear accelerator cavities) and can be used as a constraint in matching commands. The calculation of the beta functions and phase advance is consistent with that in other codes that treat acceleration such as TRANSPORT or DIMAD. These modifications allow this version of MAD to be used for the design and modeling of linacs and the authors present examples from the Next Linear Collider design as well as a muon acceleration complex. The code is available from CERN or SLAC

  10. Property transfer assessments should include radon gas testing

    International Nuclear Information System (INIS)

    There are two emerging influences that will require radon gas testing as part of many property transfers and most environmental assessments. These requirements come from lending regulators and state legislatures and affect single family, multifamily, and commercial properties. Fannie Mae and others have developed environmental investigation guidelines for protection from long term legal liabilities in the purchase of environmentally contaminated real estate. These guidelines include radon gas testing for many properties. Several states have enacted laws that require environmental disclosure forms be prepared to ensure that the parties involved in certain real estate transactions are aware of the environmental liabilities that may come with the transfer of property. Indiana has recently enacted legislation that would require the disclosure of the presence of radon gas on many commercial real estate transactions. With more banks and state governments following this trend, radon gas testing should be performed during all property transfers and environmental assessments to protect the parties involved from any long term legal liabilities

  11. A Case for Including Transactions in OpenMP

    Energy Technology Data Exchange (ETDEWEB)

    Wong, M; Bihari, B L; de Supinski, B R; Wu, P; Michael, M; Liu, Y; Chen, W

    2010-01-25

    Transactional Memory (TM) has received significant attention recently as a mechanism to reduce the complexity of shared memory programming. We explore the potential of TM to improve OpenMP applications. We combine a software TM (STM) system to support transactions with an OpenMP implementation to start thread teams and provide task and loop-level parallelization. We apply this system to two application scenarios that reflect realistic TM use cases. Our results with this system demonstrate that even with the relatively high overheads of STM, transactions can outperform OpenMP critical sections by 10%. Overall, our study demonstrates that extending OpenMP to include transactions would ease programming effort while allowing improved performance.

  12. Time-dependent accident sequences including human actions

    International Nuclear Information System (INIS)

    During an accident, transitions between plant states can occur due to operator intervention and the failure of systems while running. The latter cause of transition is much less likely than the first, which includes errors of commission and omission as well as recovery of lost functions. A methodology has been developed to model these transitions in the time domain. As an example, it is applied to the analysis of Three-Mile-Island-type accidents. Statistical evidence is collected and used in assessing the frequency of stuck-open power-operated relief valves at Babcock and Wilcox plants as well as the frequency of misdiagnosis. Statistical data are also used in modeling the timing of operator actions during the accident, i.e., turning off and on the high-pressure injection system and closing the block valves

  13. Molecular phylogeny of coronaviruses including human SARS-CoV

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Phylogenetic tree of coronaviruses (CoVs) including the human SARS-associated virus is reconstructed from complete genomes by using our newly developed K- string composition approach. The relation of the human SARS-CoV to other coronaviruses, i.e. the rooting of the tree is suggested by choosing an appropriate outgroup. SARS-CoV makes a separate group closer but still distant from G2 (CoVs in mammalian host). The relation between different isolates of the human SARS virus is inferred by first constructing an ultrametric distance matrix from counting sequence variations in the genomes. The resulting tree is consistent with clinic relations between the SARS-CoV isolates. In addition to a larger variety of coronavirus genomes these results provide phylogenetic knowledge based on independent novel methodology as compared to recent phylogenetic studies on SARS-CoV.

  14. Numerical modelling of coal spontaneous combustion with moisture included

    Energy Technology Data Exchange (ETDEWEB)

    Arisoy, A. [Istanbul Technical University, Istanbul (Turkey). Mechanical Engineering Faculty

    2005-07-01

    A mathematical model for spontaneous combustion of coal with moisture included is presented. The one-dimensional unsteady state model consists of conservation equations for oxygen, water vapour and inherent moisture of coal and energy for both gaseous and solid phases. A first order Arrhenius reaction rate for oxidation under both pore diffusion and chemically controlled reaction regime is considered. The rate of evaporation or condensation is also considered as a function of temperature of coal, water content of coal and gas streams. The equation of the model is solved numerically by the finite difference technique. Influences of different parameters on the process of spontaneous combustion can be examined by using this model. Also the model can be used to simulate full-scale storage conditions. 4 refs., 5 figs., 1 tab.

  15. Fuel cell repeater unit including frame and separator plate

    Science.gov (United States)

    Yamanis, Jean; Hawkes, Justin R; Chiapetta, Jr., Louis; Bird, Connie E; Sun, Ellen Y; Croteau, Paul F

    2013-11-05

    An example fuel cell repeater includes a separator plate and a frame establishing at least a portion of a flow path that is operative to communicate fuel to or from at least one fuel cell held by the frame relative to the separator plate. The flow path has a perimeter and any fuel within the perimeter flow across the at least one fuel cell in a first direction. The separator plate, the frame, or both establish at least one conduit positioned outside the flow path perimeter. The conduit is outside of the flow path perimeter and is configured to direct flow in a second, different direction. The conduit is fluidly coupled with the flow path.

  16. Actuator assembly including a single axis of rotation locking member

    Science.gov (United States)

    Quitmeyer, James N.; Benson, Dwayne M.; Geck, Kellan P.

    2009-12-08

    An actuator assembly including an actuator housing assembly and a single axis of rotation locking member fixedly attached to a portion of the actuator housing assembly and an external mounting structure. The single axis of rotation locking member restricting rotational movement of the actuator housing assembly about at least one axis. The single axis of rotation locking member is coupled at a first end to the actuator housing assembly about a Y axis and at a 90.degree. angle to an X and Z axis providing rotation of the actuator housing assembly about the Y axis. The single axis of rotation locking member is coupled at a second end to a mounting structure, and more particularly a mounting pin, about an X axis and at a 90.degree. angle to a Y and Z axis providing rotation of the actuator housing assembly about the X axis. The actuator assembly is thereby restricted from rotation about the Z axis.

  17. When Supporting Children with Disabilities is Both Including and Excluding

    DEFF Research Database (Denmark)

    Engsig, Thomas Thyrring

    2016-01-01

    A recent political decree in Denmark outlined an ambitious goal regarding the inclusion of students with special needs in the general education. 97% of the country’s students are to receive their education in the public school’s general education by 2020. Research indicates that the use of in...... for these students (Alborz, 2009; Blatchford et al., 2009; Blatchford, Bassett, Brown, & Webster, 2009; Dyssegaard & Larsen, 2013). The traditional understandings and definitions of inclusive education in a Danish educational context seem to be inadequate due to the fact, that the student’s subjective experience...... of being included is being neglected as a significant dimension of the notion of inclusion. The presentation will entail a discussion of the implications of the use of inclusive in-class support in the Danish general education in relation to the student’s participation in the communities of the general...

  18. OPAL Central Detector (Including vertex, jet and Z chambers)

    CERN Multimedia

    OPAL was one of the four experiments installed at the LEP particle accelerator from 1989 - 2000. OPAL's central tracking system consists of (in order of increasing radius) a silicon microvertex detector, a vertex detector, a jet chamber, and z-chambers. All the tracking detectors work by observing the ionization of atoms by charged particles passing by: when the atoms are ionized, electrons are knocked out of their atomic orbitals, and are then able to move freely in the detector. These ionization electrons are detected in the different parts of the tracking system. (This piece includes the vertex, jet and Z chambers) In the picture above, the central detector is the piece being removed to the right.

  19. The Physics of Semiconductors An Introduction Including Nanophysics and Applications

    CERN Document Server

    Grundmann, Marius

    2010-01-01

    The Physics of Semiconductors contains ample material for a comprehensive upper-level undergraduate or beginning graduate course, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. Coverage also includes additional advanced topics, such as Bragg mirrors, resonators, polarized and magnetic semiconductors. The text derives explicit formulas for many results to support better understanding of the topics. The Physics of Semiconductors requires little or no prior knowledge of solid-state physics and evolved from a highly regarded two...

  20. Hydraulic engine valve actuation system including independent feedback control

    Science.gov (United States)

    Marriott, Craig D

    2013-06-04

    A hydraulic valve actuation assembly may include a housing, a piston, a supply control valve, a closing control valve, and an opening control valve. The housing may define a first fluid chamber, a second fluid chamber, and a third fluid chamber. The piston may be axially secured to an engine valve and located within the first, second and third fluid chambers. The supply control valve may control a hydraulic fluid supply to the piston. The closing control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the second fluid chamber to the supply control valve. The opening control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the supply control valve to the second fluid chamber.

  1. Relativistic bound state approach to fundamental forces including gravitation

    Directory of Open Access Journals (Sweden)

    Morsch H.P.

    2012-06-01

    Full Text Available To describe the structure of particle bound states of nature, a relativistic bound state formalism is presented, which requires a Lagrangian including scalar coupling of two boson fields. The underlying mechanisms are quite complex and require an interplay of overlapping boson fields and fermion-antifermion production. This gives rise to two potentials, a boson-exchange potential and one identified with the long sought confinement potential in hadrons. With minimal requirements, two elementary massless fermions (quantons - with and without charge - and one gauge boson, hadrons and leptons but also atoms and gravitational systems are described by bound states with electric and magnetic coupling between the charges and spins of quantons. No need is found for colour, Higgs-coupling and supersymmetry.

  2. Configuration based Collisional-Radiative Model including configuration interaction

    Science.gov (United States)

    Busquet, Michel

    2007-11-01

    Atomic levels mixing through Configuration Interaction (CI) yields important effects. It transfers oscillator strengthes from allowed lines to forbidden lines, and produces strong shift and broadening of line arrays, although the total emissivity is almost insensitive to CI, being proportional to the average wave number. However for hi Z material, like Xe or Sn (potential xuv-ray source for micro-lithography), a non-LTE calculation accounting for all relevant levels wiill be untractable with billions of states. The model we constructed, CAVCRM (caf'e-crème), is a non-LTE C.R.M. where states are configurations but it includes C.I. to give full richness of spectral quantities, using the latest version of the HULLAC-v9 suite of codes and our newly developped algorithm for large set of states with as many as 50,000 states [1]. [1] M.Klapisch et al, this conference

  3. Traversing Cosmological Singularities, Complete Journeys Through Spacetime Including Antigravity

    CERN Document Server

    Bars, Itzhak

    2012-01-01

    A unique description of the Big Crunch-Big Bang transition is given at the classical gravity level, along with a complete set of homogeneous, isotropic, analytic solutions in scalar-tensor cosmology, with radiation and curvature. All solutions repeat cyclically; they have been obtained by using conformal gauge symmetry (Weyl symmetry) as a powerful tool in cosmology, and more generally in gravity. The significance of the Big Crunch-Big Bang transition is that it provides a model independent analytic resolution of the singularity, as an unambiguous and unavoidable solution of the equations at the classical gravitational physics level. It is controlled only by geometry (including anisotropy) and only very general features of matter coupled to gravity, such as kinetic energy of a scalar field, and radiation due to all forms of relativistic matter. This analytic resolution of the singularity is due to an attractor mechanism created by the leading terms in the cosmological equation. It is unique, and it is unavoid...

  4. Improving Planck calibration by including frequency-dependent relativistic corrections

    CERN Document Server

    Quartin, Miguel

    2015-01-01

    The Planck satellite detectors are calibrated in the 2015 release using the "orbital dipole", which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10^(-3), due to coupling with the "solar dipole" (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  5. Improving Planck calibration by including frequency-dependent relativistic corrections

    Science.gov (United States)

    Quartin, Miguel; Notari, Alessio

    2015-09-01

    The Planck satellite detectors are calibrated in the 2015 release using the "orbital dipole", which is the time-dependent dipole generated by the Doppler effect due to the motion of the satellite around the Sun. Such an effect has also relativistic time-dependent corrections of relative magnitude 10-3, due to coupling with the "solar dipole" (the motion of the Sun compared to the CMB rest frame), which are included in the data calibration by the Planck collaboration. We point out that such corrections are subject to a frequency-dependent multiplicative factor. This factor differs from unity especially at the highest frequencies, relevant for the HFI instrument. Since currently Planck calibration errors are dominated by systematics, to the point that polarization data is currently unreliable at large scales, such a correction can in principle be highly relevant for future data releases.

  6. Goldilocks Models of Higher-Dimensional Inflation (including modulus stabilization)

    CERN Document Server

    Burgess, C P; Hayman, Peter; Patil, Subodh P

    2016-01-01

    We explore the mechanics of inflation in simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like in that they are just complicated enough to include a mechanism to stabilize the extra-dimensional size, yet simple enough to solve the full 6D field equations using basic tools. The solutions are not limited to the effective 4D regime with H m_KK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict eta ~ 0 hence n_s ~ 0.96 and r ~ 0.096 and so are ruled out if tensor modes remain unseen. Analysis of general parameters is difficult without a full 6D fluctuation calculation.

  7. The physics of semiconductors an introduction including nanophysics and applications

    CERN Document Server

    Grundmann, Marius

    2016-01-01

    The 3rd edition of this successful textbook contains ample material for a comprehensive upper-level undergraduate or beginning graduate course, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. Coverage also includes additional advanced topics, such as Bragg mirrors, resonators, polarized and magnetic semiconductors, nanowires, quantum dots, multi-junction solar cells, thin film transistors, carbon-based nanostructures and transparent conductive oxides. The text derives explicit formulas for many results to support better under...

  8. Loan Products Included in the Offer of Commercial Banks

    Directory of Open Access Journals (Sweden)

    Vasile Dedu

    2009-04-01

    Full Text Available A bank loan is the main form of economical credit. It is for corporate activities – for medium and big companies and for retail activities – for small companies and individuals. The conditions for credit mainly depend on the quality of customers, it means their ability to perform a profitable activity and to be able to pay back the credits. For reasons which are mainly connected to marketing, bank practice has developed a large range of credit names, trying to emphasize some of the parts of the products or to take profit of some competition advantages in relation with customers’ products. We are trying to include the offer of bank loans in a typology which takes into account the law, the bank field rules and the main technical features of the offered products.

  9. Oscillatory burning of solid propellants including gas phase time lag.

    Science.gov (United States)

    T'Ien, J. S.

    1972-01-01

    An analysis has been performed for oscillatory burning of solid propellants including gas phase time lag. The gaseous flame is assumed to be premixed and laminar with a one-step overall chemical reaction. The propellant is assumed to decompose according to the Arrenhius Law, with no condensed phase reaction. With this model, strong gas phase resonance has been found in certain cases at the characteristic gas-phase frequencies, but the peaking of the acoustic admittance is in the direction favoring the damping of pressure waves. At still higher frequencies, moderate wave-amplifying ability was found. The limit of low frequency response obtained previously by Denison and Baum was recovered, and the limitations of the quasi-steady theory were investigated.

  10. Dynamic Analysis of Wind Turbines Including Soil-Structure Interaction

    DEFF Research Database (Denmark)

    Harte, M.; Basu, B.; Nielsen, Søren R.K.

    2012-01-01

    for displacement of the turbine system are obtained and the modal frequencies of the combined turbine-foundation system are estimated. Simulations are presented for the MDOF turbine structure subjected to wind loading for different soil stiffness conditions. Steady state and turbulent wind loading, developed using......This paper investigates the along-wind forced vibration response of an onshore wind turbine. The study includes the dynamic interaction effects between the foundation and the underlying soil, as softer soils can influence the dynamic response of wind turbines. A Multi-Degree-of-Freedom (MDOF......) horizontal axes onshore wind turbine model is developed for dynamic analysis using an Euler–Lagrangian approach. The model is comprised of a rotor blade system, a nacelle and a flexible tower connected to a foundation system using a substructuring approach. The rotor blade system consists of three rotating...

  11. PASCAL for engineers: A course including OMEGASOFT PASCAL for microcomputers

    International Nuclear Information System (INIS)

    These are the notes of a PASCAL course for controls engineers at CERN. The course starts with 'Standard Pascal' and includes OMEGASOFT Pascal, a powerful extension of Pascal towards real-time and systems applications. It demonstrates how a language such as Pascal, with adequate extensions for systems programming and embedded microprocessor-driven systems, can substantially increase the productivity of programmers and the reliability of their products. Also enhanced will be the legibility of the programs and their maintainability, since programming in Pascal automatically leads to autodocumentation. Simple examples show how OMEGASOFT-PASCAL can be used for efficient programming of embedded systems for real-time data acquisition and control using the MC6809 microprocessor. (orig.)

  12. An Axisymmetrical Acoustic BEM Formulation Including Visco-Thermal Losses

    DEFF Research Database (Denmark)

    Cutanda Henriquez, Vicente; Juhl, Peter Møller

    2011-01-01

    Sound waves in air experience losses due to viscous friction and thermal exchange, which become particularly relevant in a thin boundary layer over the domain boundaries. The lossless wave equation can still be used when the thickness of the boundary layer is small as compared with the setup...... dimensions. However, this is not usually true for small devices such as microphones, hearing aids, couplers, MEMS devices, mobile phones, etc., and then the losses need to be modeled. In this paper a numerical implementation of the Boundary Element Method (BEM) which includes visco-thermal losses...... is presented. The formulation is based on the Kirchoff method, where acoustic, thermal and viscous effects are decoupled everywhere except at the boundaries. This BEM formulation does not impose geometrical restrictions to the setup and can be applied to any axisymmetrical object, as long as the division...

  13. Cellular automata simulation of traffic including cars and bicycles

    Science.gov (United States)

    Vasic, Jelena; Ruskin, Heather J.

    2012-04-01

    As 'greening' of all aspects of human activity becomes mainstream, transportation science is also increasingly focused around sustainability. Modal co-existence between motorised and non-motorised traffic on urban networks is, in this context, of particular interest for traffic flow modelling. The main modelling problems here are posed by the heterogeneity of vehicles, including size and dynamics, and by the complex interactions at intersections. Herein we address these with a novel technique, based on one-dimensional cellular automata components, for modelling network infrastructure and its occupancy by vehicles. We use this modelling approach, together with a corresponding vehicle behaviour model, to simulate combined car and bicycle traffic for two elemental scenarios-examples of components that would be used in the building of an arbitrary network. Results of simulations performed on these scenarios, (i) a stretch of road and (ii) an intersection causing conflict between cars and bicycles sharing a lane, are presented and analysed.

  14. Neutrinos from Cosmic Accelerators including Magnetic Field and Flavor Effects

    Directory of Open Access Journals (Sweden)

    Walter Winter

    2012-01-01

    Full Text Available We review the particle physics ingredients affecting the normalization, shape, and flavor composition of astrophysical neutrinos fluxes, such as different production modes, magnetic field effects on the secondaries (muons, pions, and kaons, and flavor mixing, where we focus on pγ interactions. We also discuss the interplay with neutrino propagation and detection, including the possibility to detect flavor and its application in particle physics, and the use of the Glashow resonance to discriminate pγ from pp interactions in the source. We illustrate the implications on fluxes and flavor composition with two different models: (1 the target photon spectrum is dominated by synchrotron emission of coaccelerated electrons and (2 the target photon spectrum follows the observed photon spectrum of gamma-ray bursts. In the latter case, the multimessenger extrapolation from the gamma-ray fluence to the expected neutrino flux is highlighted.

  15. Recent progress and advances in iterative software (including parallel aspects)

    Energy Technology Data Exchange (ETDEWEB)

    Carey, G.; Young, D.M.; Kincaid, D. [and others

    1994-12-31

    The purpose of the workshop is to provide a forum for discussion of the current state of iterative software packages. Of particular interest is software for large scale engineering and scientific applications, especially for distributed parallel systems. However, the authors will also review the state of software development for conventional architectures. This workshop will complement the other proposed workshops on iterative BLAS kernels and applications. The format for the workshop is as follows: To provide some structure, there will be brief presentations, each of less than five minutes duration and dealing with specific facets of the subject. These will be designed to focus the discussion and to stimulate an exchange with the participants. Issues to be covered include: The evolution of iterative packages, current state of the art, the parallel computing challenge, applications viewpoint, standards, and future directions and open problems.

  16. A solid fuel which includes coal, coke and charcoal

    Energy Technology Data Exchange (ETDEWEB)

    Takeuti, Y.; Iketani, Y.; Nisino, A.; Sonetaka, K.

    1983-04-15

    A composition of solid domestic fuel is proposed with a reduced liberation of toxic gases (CO and hydrocarbon (Uv)) upon combustion. The fuel is produced from (percent) 80 mineral coal, 10 charcoal, 10 CaC03 with an additive of 2 percent methylcellulose to the charge. Briquets are made from the mixture with perforated openings which have a transverse cross section (PS) of 10 to 200 square millimeters. The ratio of the total transverse cross section of all the openings and the transverse cross section of the fuel briquet, including the area of the openings is 25 to 70. Systems for disposition of the openings in the fuel are cited, along with the cross section of a furnace with the loaded fuel and the dependencies of the CO content in the furnace gas on the properties of the fuel.

  17. Visió general de la discussió sobre les àrees d’exclusió del projecte INCLUD-ED General overview of the discussion on exclusion areas in the INCLUD-ED project Visión general de la discusión sobre las áreas de exclusión del proyecto INCLUD-ED

    Directory of Open Access Journals (Sweden)

    Carme García

    2010-01-01

    Full Text Available En aquest article es discuteixen les aportacions que es fan des del projecte INCLUD-ED: Strategies for inclusion and social cohesion from education in Europe sobre la relació que es pot establir entre l’exclusió/inclusió educativa i l’exclusió/inclusió en quatre àrees de la societat: ocupació, habitatge, salut i participació social i política. En particular, es reflexiona sobre els efectes que té tant l’exclusió, com formes de superar-la i promoure la inclusió, en les situacions que han d’afrontar les persones que pertanyen a algun dels cinc grups vulnerables que es defineixen en el projecte INCLUD-ED. Es presenta una visió general de l’estat de la qüestió sobre les investigacions i anàlisis de les àrees d’exclusió. Conclou amb unes breus reflexions sobre com superar les situacions d’exclusió i quines alternatives d’actuació s’obren des de l’àmbit educatiu. ____________________________________________ Dans cet article, nous discutons les contributions que fait le projet INCLUD-ED sur la relation que l’on peut établir entre l’exclusion/inclusion éducative et l’exclusion/inclusion dans quatre domaines de la société : emploi, logement, santé et participation sociale et politique. En particulier, nous réfléchissons sur les effets de l’exclusion ainsi que sur les manières de la dépasser et de promouvoir l’inclusion dans les situations que doivent affronter les individus appartenant à l’un des cinq groupes vulnérables qui sont définis dans le projet INCLUD-ED. Nous présentons une vision générale de l’état de la question sur les recherches et les analyses des domaines d’exclusion. L'article conclut avec de brèves réflexions sur la manière de dépasser les situations d’exclusion et sur les alternatives d’intervention qui s’ouvrent dans le domaine éducatif.In this paper, we discuss the contributions of the INCLUD-ED project to the relationship that can be established

  18. Extending Vulnerability Assessment to Include Life Stages Considerations

    Science.gov (United States)

    Hodgson, Emma E.; Essington, Timothy E.; Kaplan, Isaac C.

    2016-01-01

    Species are experiencing a suite of novel stressors from anthropogenic activities that have impacts at multiple scales. Vulnerability assessment is one tool to evaluate the likely impacts that these stressors pose to species so that high-vulnerability cases can be identified and prioritized for monitoring, protection, or mitigation. Commonly used semi-quantitative methods lack a framework to explicitly account for differences in exposure to stressors and organism responses across life stages. Here we propose a modification to commonly used spatial vulnerability assessment methods that includes such an approach, using ocean acidification in the California Current as an illustrative case study. Life stage considerations were included by assessing vulnerability of each life stage to ocean acidification and were used to estimate population vulnerability in two ways. We set population vulnerability equal to: (1) the maximum stage vulnerability and (2) a weighted mean across all stages, with weights calculated using Lefkovitch matrix models. Vulnerability was found to vary across life stages for the six species explored in this case study: two krill–Euphausia pacifica and Thysanoessa spinifera, pteropod–Limacina helicina, pink shrimp–Pandalus jordani, Dungeness crab–Metacarcinus magister and Pacific hake–Merluccius productus. The maximum vulnerability estimates ranged from larval to subadult and adult stages with no consistent stage having maximum vulnerability across species. Similarly, integrated vulnerability metrics varied greatly across species. A comparison showed that some species had vulnerabilities that were similar between the two metrics, while other species’ vulnerabilities varied substantially between the two metrics. These differences primarily resulted from cases where the most vulnerable stage had a low relative weight. We compare these methods and explore circumstances where each method may be appropriate. PMID:27416031

  19. Epithelioid Schwannomas: An Analysis of 58 Cases Including Atypical Variants.

    Science.gov (United States)

    Hart, Jesse; Gardner, Jerad M; Edgar, Mark; Weiss, Sharon W

    2016-05-01

    The histologic features and outcome of 58 cases of epithelioid schwannoma were studied to determine the significance of atypical histologic features. Cases were retrieved from personal consultation files from 1999 to 2013. Patients (31 male and 26 female patients) ranged in age from 14 to 80 years (median, 38 y). Two patients had schwannomatosis 1. Tumors developed in the dermis/subcutis (n=56) or muscle (n=2) of the upper extremity (34.5%), lower extremity (34.5%), thorax/abdomen/back (18%), and less common anatomic locations including the scalp, neck, lip, and breast. They ranged in size from 0.25 to 4.5 cm (median, 2.0 cm). Typically circumscribed and surrounded by a perineurium, they comprised single or small groups of epithelioid schwann cells with a moderate amphophilic cytoplasm and occasional nuclear pseudoinclusions. Stroma varied from myxoid to hyalinized, often with thick-walled vessels (55 cases). Mitotic rate ranged from 0 to 9 mitoses/10 high-power field (HPF) (2.37 mm) in the most active areas (mean, 2 to 3 mitoses/10 HPFs). Thirteen cases (22%) were "atypical," defined by a high mitotic rate (≥3 mitoses per 10 HPFs) and nuclear size variation (≥3:1). All (56/56) expressed S100 protein; type IV collagen invested groups or individual cells (16/17). Melanoma markers were negative, except for melan A (1 case). Follow-up in 39 patients (median, 78 mo; range, 6 to 174 mo) indicated that 31 (79%) were alive without disease (including 9/13 atypical cases; median, 78 mo), 7 (18%) were alive with unknown status, and 1 patient had died of unrelated causes. One tumor recurred, but none metastasized. Epithelioid schwannomas, even those with atypical features, are benign and do not constitute a histologic continuum with epithelioid malignant peripheral nerve sheath tumors, which typically occur in deep soft tissues and have more anaplastic features. PMID:26752543

  20. Core training in surgery: what does it need to include?

    Science.gov (United States)

    Potts, John R

    2006-12-01

    Core training for surgeons in any surgical specialty should include education in the relevant basic science knowledge, training in fundamental diagnostic skills, the development of surgical technical skills and considerable experience in patient care. However, for a number of reasons it is no longer acceptable to guide such training based only on such broad goals, not the least of which is the advent of resident duty-hour limitations that make it unrealistic to expect residents to simply acquire, by random observation and participation, all of the important elements of their future practices. Rather, it is necessary to provide a curriculum of learning opportunities specifically structured to allow them to gain the requisite knowledge and skills. Thus, the curriculum for the core surgical training of future vascular surgeons should be based on a very specific learning objectives, stating what information is to be learned or what action is to be done, under what conditions they are to be performed, and what criteria will be used to ascertain the acquisition of the necessary knowledge or skill. Next, the best methods of instruction, including reading materials, lectures, and exposure to specific surgical procedures must be defined and the appropriate instructional materials identified, selecting the best of existing materials or, if necessary, creating them. Finally, the residents' acquisition of knowledge and skills must be assessed. Previously this occurred through a loose combination of performance evaluations from clinical rotations, faculty group discussions, and annual in-training exams culminated in the American Board of Surgery certification process. Now evaluation must relate to specific educational objectives. This is all a daunting task currently being undertaken by vascular surgery program directors, albeit with input from the Residency Review Committee and the Vascular Surgery Board of the American Board of Surgery. Eventually, overall surgical curriculum

  1. Including a learner with physical disabilities: stressful for teachers?

    Directory of Open Access Journals (Sweden)

    I. Eloff

    2002-08-01

    Full Text Available Learners with physical disabilities have been entering mainstream schools for some years now. Whereas early research on inclusive education necessitated a strong focus on the needs of the learners, there has also been a recent interest in the role of the teachers in inclusive education. By adopting constructivism as the paradigm for inquiry a study was undertaken to establish the stress factors for teachers who have to include a learner with a physical disability in their mainstream classes. The rationale for the study is threefold: i Learners with physical disabilities are entering mainstream schools increasingly, ii it is often assumed that inclusive education is too stressful for teachers to cope with, and iii related research has shown that increased contact with individuals with disabilities has a positive effect on attitudes towards individuals with disabilities. In accordance with the dialectical methodology of constructivism, the Teacher Stress and Coping Questionnaire and in-depth interviews were utilised to establish the stress factors and the extent of the stress factors that may be present. The aim of the constructivist inquiry process is to promote understanding and reconstruction. In this article the quantitative results indicate overall low or non-existent levels of stress in teachers who have to include a learner with a physical disability, and the results therefore contribute to our understanding of this situation. The qualitative results reconstruct the meanings that these teachers attach to the inclusion of a learner with a physical disability and reveal some albeit limited concerns about the communication processes between parents and teachers and a perceived lack of pre-service training.

  2. Measurement of visceral fat: should we include retroperitoneal fat?

    Directory of Open Access Journals (Sweden)

    Chi-Sheng Hung

    Full Text Available OBJECTIVE: Whether retroperitoneal fat should be included in the measurement of visceral fat remains controversial. We compared the relationships of fat areas in peritoneal, retroperitoneal, and subcutaneous compartments to metabolic syndrome, adipokines, and incident hypertension and diabetes. METHODS: We enrolled 432 adult participants (153 men and 279 women in a community-based cohort study. Computed tomography at the umbilicus level was used to measure the fat areas. RESULTS: Retroperitoneal fat correlated significantly with metabolic syndrome (adjusted odds ratio (OR, 5.651, p<0.05 and the number of metabolic abnormalities (p<0.05. Retroperitoneal fat area was significantly associated with blood pressure, plasma glycemic indices, lipid profile, C-reactive protein, adiponectin (r =  -0.244, P<0.05, and leptin (r = 0.323, p<0.05, but not plasma renin or aldosterone concentrations. During the 2.94 ± 0.84 years of follow-up, 32 participants developed incident hypertension. Retroperitoneal fat area (hazard ration (HR 1.62, p = 0.003 and peritoneal fat area (HR 1.62, p = 0.009, but not subcutaneous fat area (p = 0.14 were associated with incident hypertension. Neither retroperitoneal fat area, peritoneal fat area, nor subcutaneous fat areas was associated with incident diabetes after adjustment. CONCLUSIONS: Retroperitoneal fat is similar to peritoneal fat, but differs from subcutaneous fat, in terms of its relationship with metabolic syndrome and incident hypertension. Retroperitoneal fat area should be included in the measurement of visceral fat for cardio-metabolic studies in human.

  3. Strategies for replacement of obsolete equipment, including reverse engineering

    International Nuclear Information System (INIS)

    The presentation shall detail the challenges facing nuclear power plants with the replacement of obsolete equipment and the strategies used to overcome those challenges. The presentation will outline the common equipment types which are either obsolete or are becoming obsolete, with a focus on safety related components. The four options of the obsolete equipment replacement philosophy will be presented with replacement examples from each of the options shown for discussion purposes. Detailed examples from each of the four obsolete equipment replacement options of, (1) commercially available equivalent component, (2) modification of a commercial available component, (3) reverse engineering of the original component and finally (4) design changes using a new component, shall be presented to evaluate the advantages and disadvantages of each option. The presentation will include the technical challenges, cost and schedule concerns for each of the four options. Emphasis will be placed on the technological challenges associated with replacing old and obsolete equipment. The following is a bullet list of the challenges which will be discussed: 1) Missing, misleading or no information on the original component. 2) Acquiring information from the original equipment manufacturer and the plant. 3) Using a sample component for the replacement evaluation and or reverse engineering. 4) Reverse engineering old equipment with newly available discrete components. The presentation will include the equivalency documentation using the EPRI guidelines when replacing an original component with a different yet form, fit and functional equivalent component. The presentation will conclude with a discussion of the advantages and disadvantages of the replacement of the obsolete component with a form, fit and functional equivalent component vs. the replacement of the original component with a new component with today's technology. (author)

  4. Extending Vulnerability Assessment to Include Life Stages Considerations.

    Directory of Open Access Journals (Sweden)

    Emma E Hodgson

    Full Text Available Species are experiencing a suite of novel stressors from anthropogenic activities that have impacts at multiple scales. Vulnerability assessment is one tool to evaluate the likely impacts that these stressors pose to species so that high-vulnerability cases can be identified and prioritized for monitoring, protection, or mitigation. Commonly used semi-quantitative methods lack a framework to explicitly account for differences in exposure to stressors and organism responses across life stages. Here we propose a modification to commonly used spatial vulnerability assessment methods that includes such an approach, using ocean acidification in the California Current as an illustrative case study. Life stage considerations were included by assessing vulnerability of each life stage to ocean acidification and were used to estimate population vulnerability in two ways. We set population vulnerability equal to: (1 the maximum stage vulnerability and (2 a weighted mean across all stages, with weights calculated using Lefkovitch matrix models. Vulnerability was found to vary across life stages for the six species explored in this case study: two krill-Euphausia pacifica and Thysanoessa spinifera, pteropod-Limacina helicina, pink shrimp-Pandalus jordani, Dungeness crab-Metacarcinus magister and Pacific hake-Merluccius productus. The maximum vulnerability estimates ranged from larval to subadult and adult stages with no consistent stage having maximum vulnerability across species. Similarly, integrated vulnerability metrics varied greatly across species. A comparison showed that some species had vulnerabilities that were similar between the two metrics, while other species' vulnerabilities varied substantially between the two metrics. These differences primarily resulted from cases where the most vulnerable stage had a low relative weight. We compare these methods and explore circumstances where each method may be appropriate.

  5. Designing monitoring programs for chemicals of emerging concern in potable reuse ⋯ What to include and what not to include?

    KAUST Repository

    Drewes, Jorg

    2012-11-01

    This study discussed a proposed process to prioritize chemicals for reclaimed water monitoring programs, selection of analytical methods required for their quantification, toxicological relevance of chemicals of emerging concern regarding human health, and related issues. Given that thousands of chemicals are potentially present in reclaimed water and that information about those chemicals is rapidly evolving, a transparent, science-based framework was developed to guide prioritization of which compounds of emerging concern (CECs) should be included in reclaimed water monitoring programs. The recommended framework includes four steps: (1) compile environmental concentrations (e.g., measured environmental concentration or MEC) of CECs in the source water for reuse projects; (2) develop a monitoring trigger level (MTL) for each of these compounds (or groups thereof) based on toxicological relevance; (3) compare the environmental concentration (e.g., MEC) to the MTL; CECs with a MEC/MTL ratio greater than 1 should be prioritized for monitoring, compounds with a ratio less than \\'1\\' should only be considered if they represent viable treatment process performance indicators; and (4) screen the priority list to ensure that a commercially available robust analytical method is available for that compound. © IWA Publishing 2013.

  6. Worldwide epidemiology of liver hydatidosis including the Mediterranean area

    Institute of Scientific and Technical Information of China (English)

    Giuseppe Grosso; Salvatore Gruttadauria; Antonio Biondi; Stefano Marventano; Antonio Mistretta

    2012-01-01

    The worldwide incidence and prevalence of cystic echinococcosis have fallen dramatically over the past several decades.Nonetheless,infection with Echinococcus granulosus (E.granulosus) remains a major public health issue in several countries and regions,even in places where it was previously at low levels,as a result of a reduction of control programmes due to economic problems and lack of resources.Geographic distribution differs by country and region depending on the presence in that country of large numbers of nomadic or semi-nomadic sheep and goat flocks that represent the intermediate host of the parasite,and their close contact with the final host,the dog,which mostly provides the transmission of infection to humans.The greatest prevalence of cystic echinococcosis in human and animal hosts is found in countries of the temperate zones,including several parts of Eurasia (the Mediterranean regions,southern and central parts of Russia,central Asia,China),Australia,some parts of America (especially South America) and north and east Africa.Echinococcosis is currently considered an endemic zoonotic disease in the Mediterranean region.The most frequent strain associated with human cystic echinococcosis appears to be the common sheep strain (G1).This strain appears to be widely distributed in all continents.The purpose of this review is to examine the distribution of E.granulosus and the epidemiology of a re-emerging disease such as cystic echinococcosis.

  7. A Reformed CDM - including new mechanisms for sustainable development

    Energy Technology Data Exchange (ETDEWEB)

    Holm Olsen, K.; Fenhann, J.

    2009-07-01

    The annual CD4CDM Perspectives Series features a topic of pivotal importance to the global carbon market. The series seeks to communicate the diverse insights and visions of leading actors in the carbon market to better inform the decisions of professionals and policymakers in developing countries. The second theme of the series focuses on how the CDM can be reformed in a post-2012 climate regime, including new mechanism for sustainable development. Seventeen contributors from the private sector, Designated National Authorities, the Executive Board, research, and development agencies present their perspective on meeting challenges such as the unequal regional distribution of CDM projects, concerns about environmental integrity and technology transfer, complex governance procedures, and questions about the CDM's contribution to sustainable development. The new ideas and solutions to these challenges proposed by the authors in this edition of Perspectives have been solicited to help professionals and policy makers make the best decisions in the lead-up to COP 15 in Copenhagen and beyond. (au)

  8. Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma.

    Science.gov (United States)

    Smith, N L; Denning, D W

    2011-04-01

    Chronic pulmonary aspergillosis (CPA) is a condition caused by the ubiquitous fungus Aspergillus fumigatus in non-immunocompromised individuals. Numerous underlying conditions have been associated with CPA. Details of the underlying conditions of 126 CPA patients attending our tertiary referral clinic from all over the UK were extracted from the clinical notes, and the distribution of these underlying conditions was analysed. For those with several underlying pulmonary conditions, one was nominated as the primary condition. Many patients presented with multiple underlying conditions, and a total of 232 underlying conditions were identified for the 126 patients. Previous classical tuberculosis and non-tuberculous mycobacterial infection were the most common primary underlying conditions (15.3% and 14.9%, respectively). Others included allergic bronchopulmonary aspergillosis (ABPA), chronic obstructive pulmonary condition (COPD) and/or emphysema, pneumothorax and prior treated lung cancer. Some conditions were found more often as one of multiple underlying conditions, while others were found only as secondary underlying conditions. Tuberculosis, non-tuberculous mycobacterial infection and ABPA remain the predominant risk factors for development of CPA, with COPD, prior pneumothorax or treated lung cancer also relatively common among our referrals. Many patients have multiple underlying pulmonary conditions. CPA should be considered when upper lobe cavitary or fibrotic disease and systemic symptoms are present in those with lung disease. PMID:20595150

  9. Project Interface Requirements Process Including Shuttle Lessons Learned

    Science.gov (United States)

    Bauch, Garland T.

    2010-01-01

    Most failures occur at interfaces between organizations and hardware. Processing interface requirements at the start of a project life cycle will reduce the likelihood of costly interface changes/failures later. This can be done by adding Interface Control Documents (ICDs) to the Project top level drawing tree, providing technical direction to the Projects for interface requirements, and by funding the interface requirements function directly from the Project Manager's office. The interface requirements function within the Project Systems Engineering and Integration (SE&I) Office would work in-line with the project element design engineers early in the life cycle to enhance communications and negotiate technical issues between the elements. This function would work as the technical arm of the Project Manager to help ensure that the Project cost, schedule, and risk objectives can be met during the Life Cycle. Some ICD Lessons Learned during the Space Shuttle Program (SSP) Life Cycle will include the use of hardware interface photos in the ICD, progressive life cycle design certification by analysis, test, & operations experience, assigning interface design engineers to Element Interface (EI) and Project technical panels, and linking interface design drawings with project build drawings

  10. Including test errors in evaluating surveillance test intervals

    International Nuclear Information System (INIS)

    To evaluate the risk impact of surveillance requirements defined in Technical Specifications, both the beneficial and negative effects of surveillance should be considered. The negative effect of surveillance testing can be caused by test errors, e.g., human errors of omission or commission including potential for common cause failures. As a consequence of the negative effect, the performance of periodic testing can have adverse impact on safety. This paper defines the various negative effects of surveillance testing from a risk perspective, and then presents a methodology to quantify the negative risk impact, i.e., the risk penalty or risk increase caused by the test. The paper presents a PRA-based method to evaluate the negative risk impact due to test-caused plant transients and a method based on a test-caused equipment degradation model and PRA to assess the negative risk impact associated with equipment wear-out. Also described in the paper are illustrative applications of the methods to specific surveillance tests conducted at boiling water reactors (BWRs) such as the tests of main steam isolation valves (MSIVs), turbine overspeed protection system, and diesel generators. Evaluation results of the risk effectiveness of the tests are presented along with the insights from the sensitivity analysis of the risk impact versus test interval

  11. Efficient Algorithms for Electrostatic Interactions Including Dielectric Contrasts

    Directory of Open Access Journals (Sweden)

    Christian Holm

    2013-10-01

    Full Text Available Coarse-grained models of soft matter are usually combined with implicit solvent models that take the electrostatic polarizability into account via a dielectric background. In biophysical or nanoscale simulations that include water, this constant can vary greatly within the system. Performing molecular dynamics or other simulations that need to compute exact electrostatic interactions between charges in those systems is computationally demanding. We review here several algorithms developed by us that perform exactly this task. For planar dielectric surfaces in partial periodic boundary conditions, the arising image charges can be either treated with the MMM2D algorithm in a very efficient and accurate way or with the electrostatic layer correction term, which enables the user to use his favorite 3D periodic Coulomb solver. Arbitrarily-shaped interfaces can be dealt with using induced surface charges with the induced charge calculation (ICC* algorithm. Finally, the local electrostatics algorithm, MEMD(Maxwell Equations Molecular Dynamics, even allows one to employ a smoothly varying dielectric constant in the systems. We introduce the concepts of these three algorithms and an extension for the inclusion of boundaries that are to be held fixed at a constant potential (metal conditions. For each method, we present a showcase application to highlight the importance of dielectric interfaces.

  12. Advocacy for women's health should include lesbian health.

    Science.gov (United States)

    O'Hanlan, Katherine A; Dibble, Suzanne L; Hagan, H Jennifer J; Davids, Rachel

    2004-03-01

    Although research confirms that homosexuality is a normal expression of human sexuality, established scientific studies are often not reflected in laws and judicial opinions for lesbians with regard to employment, taxation, pensions, disability, healthcare, immigration, military service, marriage, custody, and adoption. The expression of homosexual attraction or behavior is sometimes met by disdain or violence. Psychological and epidemiological research confirms that the public discriminatory attitudes and second-class legal status cause physical, emotional, and financial harm to lesbians, their families, and their children. Some lesbians experience discrimination in healthcare and avoid routine primary healthcare. To decrease the harm, and improve the health of lesbians, medical institutions can include sexual orientation and gender identity in their nondiscrimination policies and offer domestic partner coverage in employment benefits. Our specialty societies should review current laws and judicial opinions and advocate for change. Further, specialty societies can effect change by issuing policy statements about issues of orientation and by writing orientation/identity curricula for public schools, colleges, and postcollegiate education to improve their accuracy, reduce sexually transmitted diseases, delay sexual activity, and reduce morbidity from homophobic violence. PMID:15072737

  13. Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays

    Directory of Open Access Journals (Sweden)

    Donna H. Wang

    2011-08-01

    Full Text Available Diamond is a material of interest due to its unique combination of properties, including its chemical inertness and biocompatibility. Polycrystalline diamond (poly-C has been used in experimental biosensors that utilize electrochemical methods and antigen-antibody binding for the detection of biological molecules. Boron-doped poly-C electrodes have been found to be very advantageous for electrochemical applications due to their large potential window, low background current and noise, and low detection limits (as low as 500 fM. The biocompatibility of poly-C is found to be comparable, or superior to, other materials commonly used for implants, such as titanium and 316 stainless steel. We have developed a diamond-based, neural microelectrode-array (MEA, due to the desirability of poly-C as a biosensor. These diamond probes have been used for in vivo electrical recording and in vitro electrochemical detection. Poly-C electrodes have been used for electrical recording of neural activity. In vitro studies indicate that the diamond probe can detect norepinephrine at a 5 nM level. We propose a combination of diamond micro-machining and surface functionalization for manufacturing diamond pathogen-microsensors.

  14. Understanding type 2 diabetes: including the family member's perspective.

    LENUS (Irish Health Repository)

    White, Patricia

    2012-02-01

    PURPOSE: The purpose of this study was to examine the relationship between psychological and social factors and diabetes outcomes in people with type 2 diabetes and their family members. METHODS: A total of 153 patients with type 2 diabetes were assessed at a diabetes outpatient clinic and postal questionnaires were sent to nominated family members. The measures examined were diabetes knowledge, social support, well-being, and illness perceptions. RESULTS: When compared with those with diabetes, family members reported lower positive well-being and lower levels of satisfaction with support. They also perceived diabetes as a more cyclical illness, which was controlled more by treatment than by the individual. Family members also reported that the person with diabetes was more emotionally distressed and knew more about diabetes than the patient had actually reported himself or herself. There were no differences between the family members of those in good or poor glycaemic control. CONCLUSIONS: This study reinforces the importance of understanding social context and illness beliefs in diabetes management. It also highlights the potential for including family members in discussions and education about diabetes management.

  15. Advocacy for women's health should include lesbian health.

    Science.gov (United States)

    O'Hanlan, Katherine A; Dibble, Suzanne L; Hagan, H Jennifer J; Davids, Rachel

    2004-03-01

    Although research confirms that homosexuality is a normal expression of human sexuality, established scientific studies are often not reflected in laws and judicial opinions for lesbians with regard to employment, taxation, pensions, disability, healthcare, immigration, military service, marriage, custody, and adoption. The expression of homosexual attraction or behavior is sometimes met by disdain or violence. Psychological and epidemiological research confirms that the public discriminatory attitudes and second-class legal status cause physical, emotional, and financial harm to lesbians, their families, and their children. Some lesbians experience discrimination in healthcare and avoid routine primary healthcare. To decrease the harm, and improve the health of lesbians, medical institutions can include sexual orientation and gender identity in their nondiscrimination policies and offer domestic partner coverage in employment benefits. Our specialty societies should review current laws and judicial opinions and advocate for change. Further, specialty societies can effect change by issuing policy statements about issues of orientation and by writing orientation/identity curricula for public schools, colleges, and postcollegiate education to improve their accuracy, reduce sexually transmitted diseases, delay sexual activity, and reduce morbidity from homophobic violence.

  16. ERA's Open Rotor Studies Including Shielding for Noise Reduction

    Science.gov (United States)

    Van Zante, Dale; Thomas, Russell

    2012-01-01

    The Open Rotor is a modern version of the UnDucted Fan (UDF) that was flight tested in the late 1980's through a partnership between NASA and General Electric (GE). Tests were conducted in the 9' x 15' Low Speed Wind Tunnel and the 8' x 6' Supersonic Wind Tunnel starting in late 2009 and completed in early 2012. Aerodynamic and acoustic data were obtained for takeoff, approach and cruise simulations. GE was the primary partner, but other organizations were involved such as Boeing and Airbus who provided additional hardware for fuselage simulations. This test campaign provided the acoustic and performance characteristics for modern open rotor blades designs." NASA and GE conducted joint systems analysis to evaluate how well new blade designs would perform on a B737 class aircraft, and compared the results to an advanced higher bypass ratio turbofan." Acoustic shielding experiments were performed at NASA GRC and Boeing LSAF facilities to provide data for noise estimates of unconventional aircraft configurations with Open Rotor propulsion systems." The work was sponsored by NASA's aeronautics programs, including the Subsonic Fixed Wing (SFW) and the Environmentally Responsible Aviation (ERA) projects."

  17. A design of a computer complex including vector processors

    International Nuclear Information System (INIS)

    We, members of the Computing Center, Japan Atomic Energy Research Institute have been engaged for these six years in the research of adaptability of vector processing to large-scale nuclear codes. The research has been done in collaboration with researchers and engineers of JAERI and a computer manufacturer. In this research, forty large-scale nuclear codes were investigated from the viewpoint of vectorization. Among them, twenty-six codes were actually vectorized and executed. As the results of the investigation, it is now estimated that about seventy percents of nuclear codes and seventy percents of our total amount of CPU time of JAERI are highly vectorizable. Based on the data obtained by the investigation, (1)currently vectorizable CPU time, (2)necessary number of vector processors, (3)necessary manpower for vectorization of nuclear codes, (4)computing speed, memory size, number of parallel 1/0 paths, size and speed of 1/0 buffer of vector processor suitable for our applications, (5)necessary software and operational policy for use of vector processors are discussed, and finally (6)a computer complex including vector processors is presented in this report. (author)

  18. Progress Towards an LES Wall Model Including Unresolved Roughness

    Science.gov (United States)

    Craft, Kyle; Redman, Andrew; Aikens, Kurt

    2015-11-01

    Wall models used in large eddy simulations (LES) are often based on theories for hydraulically smooth walls. While this is reasonable for many applications, there are also many where the impact of surface roughness is important. A previously developed wall model has been used primarily for jet engine aeroacoustics. However, jet simulations have not accurately captured thick initial shear layers found in some experimental data. This may partly be due to nozzle wall roughness used in the experiments to promote turbulent boundary layers. As a result, the wall model is extended to include the effects of unresolved wall roughness through appropriate alterations to the log-law. The methodology is tested for incompressible flat plate boundary layers with different surface roughness. Correct trends are noted for the impact of surface roughness on the velocity profile. However, velocity deficit profiles and the Reynolds stresses do not collapse as well as expected. Possible reasons for the discrepancies as well as future work will be presented. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number ACI-1053575. Computational resources on TACC Stampede were provided under XSEDE allocation ENG150001.

  19. Dynamics of magnetosphere-ionosphere coupling including turbulent transport

    Science.gov (United States)

    Lysak, R. L.; Dum, C. T.

    1983-01-01

    The dynamics of magnetosphere-ionosphere coupling has been investigated by means of a two-dimensional two-fluid MHD model including anomalous resistivity. When field-aligned current is generated on auroral field lines, the disturbance propagates toward the ionosphere in the form of a kinetic Alfven wave. When the current exceeds a critical value, microscopic turbulence is produced, which modifies the propagation of the Alfven wave. This process is modeled by a nonlinear collision frequency, which increases with the excess of the drift velocity over the critical value. The system evolves toward an electrostatic structure, with the perpendicular electric field having a shorter scale than the field-aligned current. The approach to a steady state is strongly dependent on the presence or absence of the turbulence and on the boundary conditions imposed in the generator. As current is increased or scale size is decreased, the turbulent region reflects and absorbs most of the Alfven wave energy, decoupling the generator from the ionosphere.

  20. Advanced methodology for generation expansion planning including interconnected systems

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, M.; Yokoyama, R.; Yasuda, K. [Tokyo Metropolitan Univ. (Japan); Sasaki, H. [Hiroshima Univ. (Japan); Ogimoto, K. [Electric Power Development Co. Ltd., Tokyo (Japan)

    1994-12-31

    This paper reviews advanced methodology for generation expansion planning including interconnected systems developed in Japan, putting focus on flexibility and efficiency in a practical application. First, criteria for evaluating flexibility of generation planning considering uncertainties are introduced. Secondly, the flexible generation mix problem is formulated as a multi-objective optimization with more than two objective functions. The multi-objective optimization problem is then transformed into a single objective problem by using the weighting method, to obtain the Pareto optimal solution, and solved by a dynamics programming technique. Thirdly, a new approach for electric generation expansion planning of interconnected systems is presented, based on the Benders Decomposition technique. That is, large scale generation problem constituted by the general economic load dispatch problem, and several sub problems which are composed of smaller scale isolated system generation expansion plans. Finally, the generation expansion plan solved by an artificial neural network is presented. In conclusion, the advantages and disadvantages of this method from the viewpoint of flexibility and applicability to practical generation expansion planning are presented. (author) 29 refs., 10 figs., 4 tabs.

  1. Betatron Function Parameterization of Beam Optics including Acceleration

    Energy Technology Data Exchange (ETDEWEB)

    D.R. Douglas; J. Kewisch; R.C. York

    1988-10-01

    Betatron function parameterization of symplectic matrices is of recognized utility in beam optical computations. The traditional ''beta functions'' beta, alpha, gamma,(=(1+alpha{sup 2})/beta) and psi (the betratron phase advance) provide an emittance-independent representation of the properties of a beam transport system. They thereby decouple the problem of ''matching'' injected beam envelope properties to the acceptance of a particular transport system from the details of producing a beam of a specific emittance. The definition and interpretation of these parameters becomes, however, more subtle when acceleration effects, especially adiabatic damping (with associated nonsymplecticity of the transfer matrix), are included. We present algorithms relating symplectic representations of beam optics to the more commonly encountered nonsymplectic (x, x', y, y') representation which exhibits adiabatic damping. Betatron function parameterizations are made in both representations. Self-consistent physical interpretations of the betatron functions are given and applications to a standard beam transport program are made.

  2. Linezolid susceptibility in Helicobacter pylori, including strains with multidrug resistance.

    Science.gov (United States)

    Boyanova, Lyudmila; Evstatiev, Ivailo; Gergova, Galina; Yaneva, Penka; Mitov, Ivan

    2015-12-01

    Only a few studies have evaluated Helicobacter pylori susceptibility to linezolid. The aim of the present study was to assess linezolid susceptibility in H. pylori, including strains with double/multidrug resistance. The susceptibility of 53 H. pylori strains was evaluated by Etest and a breakpoint susceptibility testing method. Helicobacter pylori resistance rates were as follows: amoxicillin, 1.9%; metronidazole, 37.7%; clarithromycin, 17.0%; tetracycline, 1.9%; levofloxacin, 24.5%; and linezolid (>4 mg/L), 39.6%. The linezolid MIC50 value was 31.2-fold higher than that of clarithromycin and 10.5-fold higher than that of levofloxacin; however, 4 of 11 strains with double/multidrug resistance were linezolid-susceptible. The MIC range of the oxazolidinone agent was larger (0.125-64 mg/L) compared with those in the previous two reports. The linezolid resistance rate was 2.2-fold higher in metronidazole-resistant strains and in strains resistant to at least one antibiotic compared with the remaining strains. Briefly, linezolid was less active against H. pylori compared with clarithromycin and levofloxacin, and linezolid resistance was linked to resistance to metronidazole as well as to resistance to at least one antibiotic. However, linezolid activity against some strains with double/multidrug resistance may render the agent appropriate to treat some associated H. pylori infections following in vitro susceptibility testing of the strains. Clinical trials are required to confirm this suggestion.

  3. Interim performance criteria for photovoltaic energy systems. [Glossary included

    Energy Technology Data Exchange (ETDEWEB)

    DeBlasio, R.; Forman, S.; Hogan, S.; Nuss, G.; Post, H.; Ross, R.; Schafft, H.

    1980-12-01

    This document is a response to the Photovoltaic Research, Development, and Demonstration Act of 1978 (P.L. 95-590) which required the generation of performance criteria for photovoltaic energy systems. Since the document is evolutionary and will be updated, the term interim is used. More than 50 experts in the photovoltaic field have contributed in the writing and review of the 179 performance criteria listed in this document. The performance criteria address characteristics of present-day photovoltaic systems that are of interest to manufacturers, government agencies, purchasers, and all others interested in various aspects of photovoltaic system performance and safety. The performance criteria apply to the system as a whole and to its possible subsystems: array, power conditioning, monitor and control, storage, cabling, and power distribution. They are further categorized according to the following performance attributes: electrical, thermal, mechanical/structural, safety, durability/reliability, installation/operation/maintenance, and building/site. Each criterion contains a statement of expected performance (nonprescriptive), a method of evaluation, and a commentary with further information or justification. Over 50 references for background information are also given. A glossary with definitions relevant to photovoltaic systems and a section on test methods are presented in the appendices. Twenty test methods are included to measure performance characteristics of the subsystem elements. These test methods and other parts of the document will be expanded or revised as future experience and needs dictate.

  4. Sliding response of gravity dams including vertical seismic accelerations

    Institute of Scientific and Technical Information of China (English)

    Constantin Christopoulos; Pierre Léger; André Filiatrault

    2003-01-01

    Seismic safety assessment of gravity dams has become a major concern in many regions of the world while the effects of vertical seismic accelerations on the response of structures remain poorly understood. This paper first investigates the effect of including vertical accelerations in the sliding response analysis of gravity dams subjected to a range of historical ground motion records separated in two groups according to their source-to-site distance. Analyses showed that the incidence of vertical accelerations on the sliding response of gravity dams is significantly higher for near-source records than for farsource records. The pseudo-static 30% load combination rule, commonly used in practice to account for the non-simultaneous occurrence of the peak horizontal and vertical accelerations, yielded good approximations of the minimum safety factors against sliding computed from time-history analyses. A method for empirically estimating the vertical response spectra based on horizontal spectra, accounting for the difference in frequency content and amplitudes between the two components is investigated. Results from analyses using spectrum compatible horizontal and vertical synthetic records also approximated well the sliding response of a gravity dam subjected to series of simultaneous horizontal and vertical historical earthquake records.

  5. Olkiluoto surface hydrological modelling: Update 2012 including salt transport modelling

    International Nuclear Information System (INIS)

    Posiva Oy is responsible for implementing a final disposal program for spent nuclear fuel of its owners Teollisuuden Voima Oyj and Fortum Power and Heat Oy. The spent nuclear fuel is planned to be disposed at a depth of about 400-450 meters in the crystalline bedrock at the Olkiluoto site. Leakages located at or close to spent fuel repository may give rise to the upconing of deep highly saline groundwater and this is a concern with regard to the performance of the tunnel backfill material after the closure of the tunnels. Therefore a salt transport sub-model was added to the Olkiluoto surface hydrological model (SHYD). The other improvements include update of the particle tracking algorithm and possibility to estimate the influence of open drillholes in a case where overpressure in inflatable packers decreases causing a hydraulic short-circuit between hydrogeological zones HZ19 and HZ20 along the drillhole. Four new hydrogeological zones HZ056, HZ146, BFZ100 and HZ039 were added to the model. In addition, zones HZ20A and HZ20B intersect with each other in the new structure model, which influences salinity upconing caused by leakages in shafts. The aim of the modelling of long-term influence of ONKALO, shafts and repository tunnels provide computational results that can be used to suggest limits for allowed leakages. The model input data included all the existing leakages into ONKALO (35-38 l/min) and shafts in the present day conditions. The influence of shafts was computed using eight different values for total shaft leakage: 5, 11, 20, 30, 40, 50, 60 and 70 l/min. The selection of the leakage criteria for shafts was influenced by the fact that upconing of saline water increases TDS-values close to the repository areas although HZ20B does not intersect any deposition tunnels. The total limit for all leakages was suggested to be 120 l/min. The limit for HZ20 zones was proposed to be 40 l/min: about 5 l/min the present day leakages to access tunnel, 25 l/min from

  6. Clinical Reasoning Terms Included in Clinical Problem Solving Exercises?

    Science.gov (United States)

    Musgrove, John L; Morris, Jason; Estrada, Carlos A; Kraemer, Ryan R

    2016-05-01

    Background Published clinical problem solving exercises have emerged as a common tool to illustrate aspects of the clinical reasoning process. The specific clinical reasoning terms mentioned in such exercises is unknown. Objective We identified which clinical reasoning terms are mentioned in published clinical problem solving exercises and compared them to clinical reasoning terms given high priority by clinician educators. Methods A convenience sample of clinician educators prioritized a list of clinical reasoning terms (whether to include, weight percentage of top 20 terms). The authors then electronically searched the terms in the text of published reports of 4 internal medicine journals between January 2010 and May 2013. Results The top 5 clinical reasoning terms ranked by educators were dual-process thinking (weight percentage = 24%), problem representation (12%), illness scripts (9%), hypothesis generation (7%), and problem categorization (7%). The top clinical reasoning terms mentioned in the text of 79 published reports were context specificity (n = 20, 25%), bias (n = 13, 17%), dual-process thinking (n = 11, 14%), illness scripts (n = 11, 14%), and problem representation (n = 10, 13%). Context specificity and bias were not ranked highly by educators. Conclusions Some core concepts of modern clinical reasoning theory ranked highly by educators are mentioned explicitly in published clinical problem solving exercises. However, some highly ranked terms were not used, and some terms used were not ranked by the clinician educators. Effort to teach clinical reasoning to trainees may benefit from a common nomenclature of clinical reasoning terms.

  7. Kinetic models of gene expression including non-coding RNAs

    Science.gov (United States)

    Zhdanov, Vladimir P.

    2011-03-01

    In cells, genes are transcribed into mRNAs, and the latter are translated into proteins. Due to the feedbacks between these processes, the kinetics of gene expression may be complex even in the simplest genetic networks. The corresponding models have already been reviewed in the literature. A new avenue in this field is related to the recognition that the conventional scenario of gene expression is fully applicable only to prokaryotes whose genomes consist of tightly packed protein-coding sequences. In eukaryotic cells, in contrast, such sequences are relatively rare, and the rest of the genome includes numerous transcript units representing non-coding RNAs (ncRNAs). During the past decade, it has become clear that such RNAs play a crucial role in gene expression and accordingly influence a multitude of cellular processes both in the normal state and during diseases. The numerous biological functions of ncRNAs are based primarily on their abilities to silence genes via pairing with a target mRNA and subsequently preventing its translation or facilitating degradation of the mRNA-ncRNA complex. Many other abilities of ncRNAs have been discovered as well. Our review is focused on the available kinetic models describing the mRNA, ncRNA and protein interplay. In particular, we systematically present the simplest models without kinetic feedbacks, models containing feedbacks and predicting bistability and oscillations in simple genetic networks, and models describing the effect of ncRNAs on complex genetic networks. Mathematically, the presentation is based primarily on temporal mean-field kinetic equations. The stochastic and spatio-temporal effects are also briefly discussed.

  8. New Ballard Score, expanded to include extremely premature infants.

    Science.gov (United States)

    Ballard, J L; Khoury, J C; Wedig, K; Wang, L; Eilers-Walsman, B L; Lipp, R

    1991-09-01

    The Ballard Maturational Score was refined and expanded to achieve greater accuracy and to include extremely premature neonates. To test validity, accuracy, interrater reliability, and optimal postnatal age at examination, the resulting New Ballard Score (NBS) was assessed for 578 newly born infants and the results were analyzed. Gestational ages ranged from 20 to 44 weeks and postnatal ages at examination ranged from birth to 96 hours. In 530 infants, gestational age by last menstrual period was confirmed by agreement within 2 weeks with gestational age by prenatal ultrasonography (C-GLMP). For these infants, correlation between gestational age by NBS and C-GLMP was 0.97. Mean differences between gestational age by NBS and C-GLMP were 0.32 +/- 1.58 weeks and 0.15 +/- 1.46 weeks among the extremely premature infants (less than 26 weeks) and among the total population, respectively. Correlations between the individual criteria and C-GLMP ranged from 0.72 to 0.82. Interrater reliability of NBS, as determined by correlation between raters who rated the same subgroup of infants, ws 0.95. For infants less than 26 weeks of gestational age, the greatest validity (97% within 2 weeks of C-GLMP) was seen when the examination was performed before 12 hours of postnatal age. For infants at least 26 weeks of gestational age, percentages of agreement with C-GLMP remained constant, averaging 92% for all postnatal age categories up to 96 hours. The NBS is a valid and accurate gestational assessment tool for extremely premature infants and remains valid for the entire newborn infant population. PMID:1880657

  9. Community Assessment Tool for Public Health Emergencies Including Pandemic Influenza

    Energy Technology Data Exchange (ETDEWEB)

    HCTT-CHE

    2011-04-14

    The Community Assessment Tool (CAT) for Public Health Emergencies Including Pandemic Influenza (hereafter referred to as the CAT) was developed as a result of feedback received from several communities. These communities participated in workshops focused on influenza pandemic planning and response. The 2008 through 2011 workshops were sponsored by the Centers for Disease Control and Prevention (CDC). Feedback during those workshops indicated the need for a tool that a community can use to assess its readiness for a disaster—readiness from a total healthcare perspective, not just hospitals, but the whole healthcare system. The CAT intends to do just that—help strengthen existing preparedness plans by allowing the healthcare system and other agencies to work together during an influenza pandemic. It helps reveal each core agency partners' (sectors) capabilities and resources, and highlights cases of the same vendors being used for resource supplies (e.g., personal protective equipment [PPE] and oxygen) by the partners (e.g., public health departments, clinics, or hospitals). The CAT also addresses gaps in the community's capabilities or potential shortages in resources. While the purpose of the CAT is to further prepare the community for an influenza pandemic, its framework is an extension of the traditional all-hazards approach to planning and preparedness. As such, the information gathered by the tool is useful in preparation for most widespread public health emergencies. This tool is primarily intended for use by those involved in healthcare emergency preparedness (e.g., community planners, community disaster preparedness coordinators, 9-1-1 directors, hospital emergency preparedness coordinators). It is divided into sections based on the core agency partners, which may be involved in the community's influenza pandemic influenza response.

  10. Precise determination of Moessbauer lineshape parameters including interference

    Energy Technology Data Exchange (ETDEWEB)

    Mullen, J.G.; Djedid, A.; Bullard, B.; Schupp, G.; Cowan, D.; Cao, Y.; Crow, M.L.; Yelon, W.

    1987-01-01

    Using 100 Ci /sup 183/Ta and 5 Ci /sup 182/Ta sources, with LiF and NaCl crystal monochromating filters, we have measured the lineshape parameters for the 46.5 keV and 99.1 keV Moessbauer effect (ME) transitions of /sup 183/W and the 100.1 keV transition of /sup 182/W. Using an analytic representation of the convolution integral and utilizing asymptotic analyses of the lineshape, we find, for both transmission and microfoil internal conversion (MICE) experiments, accurate values of all ME parameters including width, position, cross section, and interference. This new approach allows deconvolution of source and absorber spectra and gives a simple analytic expression for both as well as their Fourier transforms. The line widths for the 46.5, 99.1, and 100.1 keV transitions are 3.10(10), 0.369(18), and 0.195(12) cm/s, respectively. The interference parameters are -0.00257(9), -0.0093(12), and -0.0107(12) in the same respective order. The agreement between transmission and MICE measurements for the above lineshape parameters is within the experimental errors. We believe these measurements are the first having sufficient precision to allow a quantitative comparison with dispersion theory and they indicate interference parameters 10 to 20% smaller than predicted. Our measured line widths are less than earlier reported values. This is because our analysis of the true lineshape and the study of line asymptotics permits a quantitative determination of the isomer lifetimes rather than the usual lower bound found in earlier ME experiments. 37 refs., 4 figs., 2 tabs.

  11. Deformable registration of multi-modal data including rigid structures

    Energy Technology Data Exchange (ETDEWEB)

    Huesman, Ronald H.; Klein, Gregory J.; Kimdon, Joey A.; Kuo, Chaincy; Majumdar, Sharmila

    2003-05-02

    Multi-modality imaging studies are becoming more widely utilized in the analysis of medical data. Anatomical data from CT and MRI are useful for analyzing or further processing functional data from techniques such as PET and SPECT. When data are not acquired simultaneously, even when these data are acquired on a dual-imaging device using the same bed, motion can occur that requires registration between the reconstructed image volumes. As the human torso can allow non-rigid motion, this type of motion should be estimated and corrected. We report a deformation registration technique that utilizes rigid registration for bony structures, while allowing elastic transformation of soft tissue to more accurately register the entire image volume. The technique is applied to the registration of CT and MR images of the lumbar spine. First a global rigid registration is performed to approximately align features. Bony structures are then segmented from the CT data using semi-automated process, and bounding boxes for each vertebra are established. Each CT subvolume is then individually registered to the MRI data using a piece-wise rigid registration algorithm and a mutual information image similarity measure. The resulting set of rigid transformations allows for accurate registration of the parts of the CT and MRI data representing the vertebrae, but not the adjacent soft tissue. To align the soft tissue, a smoothly-varying deformation is computed using a thin platespline(TPS) algorithm. The TPS technique requires a sparse set of landmarks that are to be brought into correspondence. These landmarks are automatically obtained from the segmented data using simple edge-detection techniques and random sampling from the edge candidates. A smoothness parameter is also included in the TPS formulation for characterization of the stiffness of the soft tissue. Estimation of an appropriate stiffness factor is obtained iteratively by using the mutual information cost function on the result

  12. Goldilocks models of higher-dimensional inflation (including modulus stabilization)

    Science.gov (United States)

    Burgess, C. P.; Enns, Jared J. H.; Hayman, Peter; Patil, Subodh P.

    2016-08-01

    We explore the mechanics of inflation within simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like inasmuch as they are just complicated enough to include a mechanism to stabilize the extra-dimensional size (or modulus), yet simple enough to solve explicitly the full extra-dimensional field equations using only simple tools. The solutions are not restricted to the effective 4D regime with H ll mKK (the latter referring to the characteristic mass splitting of the Kaluza-Klein excitations) because the full extra-dimensional Einstein equations are solved. This allows an exploration of inflationary physics in a controlled calculational regime away from the usual four-dimensional lamp-post. The inclusion of modulus stabilization is important because experience with string models teaches that this is usually what makes models fail: stabilization energies easily dominate the shallow potentials required by slow roll and so open up directions to evolve that are steeper than those of the putative inflationary direction. We explore (numerically and analytically) three representative kinds of inflationary scenarios within this simple setup. In one the radion is trapped in an inflaton-dependent local minimum whose non-zero energy drives inflation. Inflation ends as this energy relaxes to zero when the inflaton finds its own minimum. The other two involve power-law scaling solutions during inflation. One of these is a dynamical attractor whose features are relatively insensitive to initial conditions but whose slow-roll parameters cannot be arbitrarily small; the other is not an attractor but can roll much more slowly, until eventually transitioning to the attractor. The scaling solutions can satisfy H > mKK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict η simeq 0 and so r simeq 0.11 when ns simeq 0.96 and so

  13. Combination DMARD therapy including corticosteroids in early rheumatoid arthritis.

    Science.gov (United States)

    Möttönen, T T; Hannonen, P J; Boers, M

    1999-01-01

    A number of reports indicating the growing acceptance of simultaneous therapy with multiple disease-modifying anti-rheumatic drugs (DMARDs), as well as the use of more aggressive treatment measures in the early phases of disease to combat rheumatoid arthritis (RA), have appeared during the last decade. However, only a few randomized controlled clinical trials have been conducted on the use of DMARD combinations in early RA. We review these trials in this article. In two separate one-year studies combination therapy with sulphasalazine (SSZ) and methotrexate (MTX) seemed to offer no benefits compared to either drug used as monotherapy. On the other hand, the DMARD combinations so far proven to be superior to single DMARDs have initially also included a corticosteroid component. In the COBRA study (Combinatietherapie Bij Reumatoide Artritis) the combination of SSZ (2 gm/day), MTX (7.5 mg/week for 40 weeks), and prednisolone (Prd) (initially 60 mg/day, tapered in 6 weekly steps to 7.5 mg/day and stopped after 28 weeks) compared to SSZ alone (2 gm/day) resulted in significantly better clinical outcomes at week 28. Although the difference in clinical response between the treatment arms was lost at week 58, the progression of joint damage remained statistically significantly slower at week 80 in the patients initially assigned to the combination therapy. Furthermore, in the FIN-RACo trial (Finnish Rheumatoid Arthritis Combination Therapy Trial), therapy using a "tailored-steps" strategy with SSZ (1-2 gm/day), MTX (7.5-1.5 mg/week), hydroxychloroquine (300 mg/day), and Prd (up to 10 mg/day) yielded a significantly increased remission rate and less peripheral joint damage at two years than the single DMARD treatment strategy (initially SSZ 2 gm/day), with or without Prd. Adverse effects in both study arms were comparable. Two additional preliminary reports (in abstract form) suggest that intensive local therapy in the form of intra-articular injections added to single or

  14. Including collisions in gyrokinetic tokamak and stellarator simulations

    Energy Technology Data Exchange (ETDEWEB)

    Kauffmann, Karla

    2012-04-10

    ITGs and TEMs in a tokamak configuration. The results show that collisions reduce the growth rate of slab ITGs in cylinder geometry, whereas they do not affect ITGs in a tokamak, which are mainly curvature-driven. However it is important to note that the pitch-angle scattering operator does not conserve momentum, which is most critical in the parallel direction. Therefore, the damping found in a cylinder could be the consequence of this missing feature and not a physical result [Dimits and Cohen 1994]. Nonetheless, the results are useful to determine whether the instability is mainly being driven by a slab or toroidal ITG mode. EUTERPE also has the feature of including kinetic electrons, which made simulations of TEMs with collisions possible. The combination of collisions and kinetic electrons made the numerical calculations extremely time-consuming, since the time step had to be small enough to resolve the fast electron motion. In contrast to the ITG results, it was observed that collisions are extremely important for TEMs in a tokamak, and in some special cases, depending on whether they were mainly driven by density or temperature gradients, collisions could even suppress the mode (in agreement with [Angioni et al. 2005, Connor et al. 2006]). In the case of stellarators it was found that ITGs are highly dependent on the device configuration. For LHD it was shown that collisions slightly reduce the growth rate of the instability, but for Wendelstein 7-X they do not affect it and the growth rate showed a similar trend with collisionality to that of the tokamak case. Collisions also tend to make the ballooning structure of the modes less pronounced.

  15. Should LSP Dictionaries. also Include Professional Jargon and Slang?

    Directory of Open Access Journals (Sweden)

    Rosemarie Gläser

    2011-10-01

    Full Text Available

    Abstract: The paper discusses the question whether an LSP dictionary should take the sociolinguistic stratification of the entire speech community in a particular domain of activity into consideration, and as a consequence, also encompass vocabulary on the lower stylistic levels, such as professional jargon and occupational slang in addition to technical terminology and nomenclature. The author's contention is that by including such vocabulary, an LSP dictionary will be more comprehensive and closer to the communicative reality. Moreover. it will meet the more specific requirements of translators and interpreters. To substantiate this claim, the author examined two monolingual English dictionaries and five bilingual English-German (German-English dictionaries published between 1973 and 2000, which have successfully incorporated professional jargon and slang. The subject areas covered range from law, economics, accountancy and business administration to geology, geophysics, geotectonics, and to automotive engineering. Some lexicographers have used style markers or usage labels (such as informal, colloquial, slang, vulgar, umgangssprach/ ich, fdrmlich, gelwben, finance, motoring, press for vocabulary bearing stylistic or expressive connotations. As a rule, these style markers have only been given to key words of the source language so that they may be inferred for the target language equivalent. Ideally, as one dictionary author has proved, style markers should also be attached to target language equivalents. However, an LSP lexicographer must be aware of the fact that informal and slang words may be short-lived and be substituted by other colloquial and colourful words from oral communication - and that slang words may gradually lose their connotations and become stylistically neutral words and even terms.

    Keywords: LSP DICTIONARY, TECHNICAL TERM, ITEM OF NOMENCLATURE, TRIVIAL (POPULAR NAME, PROFESSIONAL JARGON, OCCUPATIONAL SLANG, TRADE

  16. 78 FR 68861 - Certain Navigation Products, Including GPS Devices, Navigation and Display Systems, Radar Systems...

    Science.gov (United States)

    2013-11-15

    ... COMMISSION Certain Navigation Products, Including GPS Devices, Navigation and Display Systems, Radar Systems... the United States after importation of certain navigation products, including GPS devices, navigation... products, including GPS devices, navigation and display systems, radar systems, navigational aids,...

  17. 77 FR 18860 - Certain Consumer Electronics, Including Mobile Phones and Tablets; Notice of Receipt of Complaint...

    Science.gov (United States)

    2012-03-28

    ... COMMISSION Certain Consumer Electronics, Including Mobile Phones and Tablets; Notice of Receipt of Complaint... complaint entitled Certain Consumer Electronics, Including Mobile Phones and Tablets, DN 2885; the... importation of certain consumer electronics, including mobile phones and tablets. The complaint names...

  18. 77 FR 44678 - Lawson Software, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Were Reported...

    Science.gov (United States)

    2012-07-30

    ... Employment and Training Administration Lawson Software, Inc., Including Workers Whose Unemployment Insurance... Software, Inc., including workers whose unemployment insurance (UI) wages were reported through Lawson... Software, Inc., including workers whose unemployment insurance (UI) wages were reported through...

  19. 75 FR 32221 - Alticor, Inc., Including Access Business Group International, LLC, and Amway Corporation...

    Science.gov (United States)

    2010-06-07

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International, LLC, and..., applicable to workers of Alticor, Inc., including Access Business Group International, LLC and Amway... location of Alticor, Inc., including Access Business Group International, LLC and Amway Corporation....

  20. 75 FR 26794 - Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena...

    Science.gov (United States)

    2010-05-12

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena Park, CA; Alticor, Inc., Including Access Business Group International LLC, and... 12, 2010, applicable to workers of Alticor, Inc., including Access Business Group International...

  1. 76 FR 45878 - Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena...

    Science.gov (United States)

    2011-08-01

    ... Employment and Training Administration Alticor, Inc., Including Access Business Group International LLC and Amway Corporation, Buena Park, CA; Alticor, Inc., Including Access Business Group International LLC and..., Ada, MI; Alticor, Inc., Including Access Business Group International LLC and Amway...

  2. Road Interchanges, Included in our street centerline file to include interchanges as a feature code for rams and interchanges, Published in unknown, Johnson County AIMS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Road Interchanges dataset, was produced all or in part from Field Survey/GPS information as of unknown. It is described as 'Included in our street centerline...

  3. Composite materials and bodies including silicon carbide and titanium diboride and methods of forming same

    Science.gov (United States)

    Lillo, Thomas M.; Chu, Henry S.; Harrison, William M.; Bailey, Derek

    2013-01-22

    Methods of forming composite materials include coating particles of titanium dioxide with a substance including boron (e.g., boron carbide) and a substance including carbon, and reacting the titanium dioxide with the substance including boron and the substance including carbon to form titanium diboride. The methods may be used to form ceramic composite bodies and materials, such as, for example, a ceramic composite body or material including silicon carbide and titanium diboride. Such bodies and materials may be used as armor bodies and armor materials. Such methods may include forming a green body and sintering the green body to a desirable final density. Green bodies formed in accordance with such methods may include particles comprising titanium dioxide and a coating at least partially covering exterior surfaces thereof, the coating comprising a substance including boron (e.g., boron carbide) and a substance including carbon.

  4. Momentum relation and classical limit in the future-not-included complex action theory

    CERN Document Server

    Nagao, Keiichi

    2013-01-01

    Studying the time development of the expectation value in the future-not-included complex action theory we point out that the momentum relation (relation analogous to $p=\\frac{\\partial L}{\\partial \\dot{q}}$), which was derived via Feynman path integral and was shown to be right in the future-included theory in our previous papers, is not valid in the future-not-included theory. We provide the correct momentum relation in the future-not-included theory, and argue that the future-not-included classical theory is described by a certain real action. In addition we provide another way to understand the time development of the future-not-included theory by utilizing the future-included theory. Furthermore, applying the method used in our previous paper to the future-not-included theory properly by introducing a formal Lagrangian, we derive the correct momentum relation in the future-not-included theory.

  5. Geologic provinces of Europe including Turkey, 2000 (prv4_2l)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This coverage includes arcs, polygons and polygon labels that describe U.S. Geological Survey defined geologic provinces of Europe including Turkey. (Albania,...

  6. Generalized Geology of Europe including Turkey (geo4_2l)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This coverage includes arcs, polygons, and polygon labels that describe the generalized geologic age of surface outcrops of bedrock of Europe including Turkey...

  7. 76 FR 41525 - Hewlett Packard Global Parts Supply Chain, Global Product Life Cycles Management Unit Including...

    Science.gov (United States)

    2011-07-14

    ... Parts Supply Chain, Global Product Life Cycles Management Unit, including teleworkers reporting to... Employment and Training Administration Hewlett Packard Global Parts Supply Chain, Global Product Life Cycles... Chain, Global Product Life Cycles Management Unit, including teleworkers reporting to Houston,...

  8. 30 CFR 285.906 - What must my decommissioning application include?

    Science.gov (United States)

    2010-07-01

    ... provide one paper copy and one electronic copy of the application. Include the following information in... discharge of pollutants, including marine trash and debris, into the offshore waters. (k) A statement...

  9. 77 FR 60720 - Certain Electronic Devices, Including Wireless Commmunication Devices, Portable Music and Data...

    Science.gov (United States)

    2012-10-04

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Electronic Devices, Including Wireless Commmunication Devices, Portable Music and Data... infringing electronic devices, including wireless communication devices, portable music and data...

  10. 77 FR 27078 - Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof...

    Science.gov (United States)

    2012-05-08

    ... Trade Commission has received a complaint entitled Certain Electronic Devices, Including Mobile Phones... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components...

  11. 75 FR 22630 - Vital Signs Minnesota, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Science.gov (United States)

    2010-04-29

    ... separate unemployment insurance (UI) tax account under the name Biomedical Dynamics Corporation... unemployment insurance (UI) wages are paid through Biomedical Dynamics Corporation, including on-site leased... Employment and Training Administration Vital Signs Minnesota, Inc., Including Workers Whose...

  12. 15 CFR 754.3 - Petroleum products not including crude oil.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Petroleum products not including crude... SUPPLY CONTROLS § 754.3 Petroleum products not including crude oil. (a) License requirement. As indicated... required to all destinations, including Canada, for the export of petroleum products, excluding crude...

  13. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Unofficial PDF copies included... Filing Requirements § 232.104 Unofficial PDF copies included in an electronic submission. (a) An... (§ 249.101 of this chapter) or a Form D (§ 239.500 of this chapter), may include one unofficial PDF...

  14. 25 CFR 170.411 - What may a long-range transportation plan include?

    Science.gov (United States)

    2010-04-01

    ... Long-Range Transportation Planning § 170.411 What may a long-range transportation plan include? A comprehensive long-range transportation plan may include: (a) An evaluation of a full range of transportation... 25 Indians 1 2010-04-01 2010-04-01 false What may a long-range transportation plan include?...

  15. 41 CFR 102-42.105 - What special information must be included on the SF 122?

    Science.gov (United States)

    2010-07-01

    ... must be included on the SF 122? 102-42.105 Section 102-42.105 Public Contracts and Property Management... and Decorations § 102-42.105 What special information must be included on the SF 122? Conspicuously mark the SF 122, “FOREIGN GIFTS AND/OR DECORATIONS”, and include all information furnished by...

  16. 34 CFR 76.104 - A State shall include certain certifications in its State plan.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false A State shall include certain certifications in its State plan. 76.104 Section 76.104 Education Office of the Secretary, Department of Education STATE... include certain certifications in its State plan. (a) A State shall include the following...

  17. 30 CFR 250.110 - What must I include in my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my welding plan? 250.110... must I include in my welding plan? You must include all of the following in the Welding Plan that you... qualified personnel weld; (c) Practices and procedures for safe welding that address: (1) Welding...

  18. Genes (including RNA editing information) - RMG | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us RMG Genes... (including RNA editing information) Data detail Data name Genes (including RNA editing information...ase Site Policy | Contact Us Genes (including RNA editing information) - RMG | LSDB Archive ...

  19. 7 CFR 1755.98 - List of telecommunications specifications included in other 7 CFR parts.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false List of telecommunications specifications included in other 7 CFR parts. 1755.98 Section 1755.98 Agriculture Regulations of the Department of Agriculture... included in other 7 CFR parts. The following specifications are included throughout 7 CFR chapter...

  20. Characterization of two different toxins of Wickerhamomyces anomalus (Pichia anomala) VKM Y-159.

    Science.gov (United States)

    Farkas, Z; Márki-Zay, J; Kucsera, Judit; Vágvölgyi, Cs; Golubev, W I; Pfeiffer, Ilona

    2012-06-01

    Wickerhamomyces anomalus VKM Y-159 strain produces two types of toxin designated as WAKT a and WAKT b, encoded by chromosomal genes. The WAKT a toxin is heat-labile, pronase sensitive acting in pH range 3-4 affecting on several yeasts including pathogenic Candida species while the WAKT b toxin is protease- and thermo-resistant, acting in pH range 3-7 on two species, Candida alai and Candida norvegica. The rapid decrease of the number of viable cells after toxin treatment demonstrates that both toxins have cytocidic effect. PMID:22695525

  1. Nanocoating of titanium implant surfaces with organic molecules. Polysaccharides including glycosaminoglycans

    DEFF Research Database (Denmark)

    Gurzawska, Katarzyna; Svava, Rikke; Jørgensen, Niklas Rye;

    2012-01-01

    with focus on polysaccharides including glycosaminoglycans, and how these molecules change surface properties, cell reactions and affect on osseointegartion. The included in vitro studies demonstrated increased cell adhesion, proliferation and mineralization of a number of the tested polysaccharide...... nanocoatings. The included in vivo studies, showed improvement of bone interface reactions measured as increased Bone-to-Implant Contact length and Bone Mineral Density adjacent to the polysaccharide coated surfaces. Based on existing literature, surface modification with polysaccharide and glycosaminoglycans...

  2. The involuntary excluder effect: those included by an excluder are seen as exclusive themselves.

    Science.gov (United States)

    Critcher, Clayton R; Zayas, Vivian

    2014-09-01

    People are highly vigilant for and alarmed by social exclusion. Previous research has focused largely on the emotional and motivational consequences of being unambiguously excluded by others. The present research instead examines how people make sense of a more ambiguous dynamic, 1-person exclusion--situations in which one person (the excluder) excludes someone (the rejected) while including someone else (the included). Using different methodological paradigms, converging outcome measures, and complementary comparison standards, 5 studies present evidence of an involuntary excluder effect: Social perceivers are quick to see included persons as though they are excluders themselves. Included individuals are seen as belonging to an exclusive alliance with the excluder, as liking the excluder more than the rejected, and as likely to perpetuate future exclusion against the rejected. Behavioral evidence reinforced these findings: The included was approached with caution and suspicion. Notably, such perceptions of the included as an excluder were drawn by the rejected themselves and outside observers alike, did not reflect the attitudes and intentions of included persons or those who simulated 1-person exclusion from the vantage point of the included, applied specifically to the included (but not someone who simply witnessed the rejected's rejection), and arose as a consequence of intentional acts of exclusion (and thus, not just because 2 individuals shared an exclusive experience). Consistencies with and contributions to literatures on balance theory, minimal groups, group entitativity, and the ostracism detection system literatures are discussed. PMID:25133726

  3. 31 CFR 205.9 - What is included in a Treasury-State agreement?

    Science.gov (United States)

    2010-07-01

    ... (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE RULES AND PROCEDURES FOR EFFICIENT FEDERAL-STATE FUNDS TRANSFERS Rules Applicable to Federal Assistance Programs Included in...

  4. 45 CFR 1308.11 - Eligibility criteria: Hearing impairment including deafness.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Eligibility criteria: Hearing impairment including deafness. 1308.11 Section 1308.11 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE... impairment including deafness. (a) A child is classified as deaf if a hearing impairment exists which is...

  5. 40 CFR 60.2630 - What should I include in my waste management plan?

    Science.gov (United States)

    2010-07-01

    ... or Before November 30, 1999 Model Rule-Waste Management Plan § 60.2630 What should I include in my waste management plan? A waste management plan must include consideration of the reduction or separation... of recyclable materials. The plan must identify any additional waste management measures, and...

  6. 40 CFR 60.3012 - What should I include in my waste management plan?

    Science.gov (United States)

    2010-07-01

    ..., 2004 Model Rule-Waste Management Plan § 60.3012 What should I include in my waste management plan? A waste management plan must include consideration of the reduction or separation of waste-stream elements.... The plan must identify any additional waste management measures and implement those measures...

  7. 30 CFR 285.610 - What must I include in my SAP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my SAP? 285.610 Section... Requirements Contents of the Site Assessment Plan § 285.610 What must I include in my SAP? Your SAP must... SAP, you must provide the following information: ER29AP09.115 (b) You must provide the results...

  8. 7 CFR 319.56-20 - Apples and pears from Australia (including Tasmania) and New Zealand.

    Science.gov (United States)

    2010-01-01

    ... apples or pears that are offered for entry into the United States. If inspection of the sample discloses... 7 Agriculture 5 2010-01-01 2010-01-01 false Apples and pears from Australia (including Tasmania... Fruits and Vegetables § 319.56-20 Apples and pears from Australia (including Tasmania) and New...

  9. 30 CFR 250.414 - What must my drilling prognosis include?

    Science.gov (United States)

    2010-07-01

    ... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations... must include a brief description of the procedures you will follow in drilling the well. This prognosis... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must my drilling prognosis include?...

  10. 25 CFR 20.401 - What is included under Services to Children, Elderly, and Families?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is included under Services to Children, Elderly, and... FINANCIAL ASSISTANCE AND SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.401 What is included under Services to Children, Elderly, and Families? Services to Children, Elderly,...

  11. 12 CFR 563b.105 - What information must I include in my business plan?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What information must I include in my business plan? 563b.105 Section 563b.105 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... expectations, and industry norms, by the final year of the business plan. You must include three years...

  12. 42 CFR 493.941 - Hematology (including routine hematology and coagulation).

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Hematology (including routine hematology and....941 Hematology (including routine hematology and coagulation). (a) Program content and frequency of challenge. To be approved for proficiency testing for hematology, a program must provide a minimum of...

  13. 21 CFR 870.1025 - Arrhythmia detector and alarm (including ST-segment measurement and alarm).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Arrhythmia detector and alarm (including ST... Diagnostic Devices § 870.1025 Arrhythmia detector and alarm (including ST-segment measurement and alarm). (a) Identification. The arrhythmia detector and alarm device monitors an electrocardiogram and is designed to...

  14. 75 FR 11922 - Apria Healthcare, Including On-Site Leased Workers From Corestaff, Ultimate Staffing (Roth...

    Science.gov (United States)

    2010-03-12

    ... Employment and Training Administration Apria Healthcare, Including On-Site Leased Workers From Corestaff... Healthcare, including on-site leased workers from Corestaff, Cromwell, Connecticut. The notice was published in the Federal Register on January 25, 2010 (75 FR 3938). At the request of the State agency,...

  15. 29 CFR 779.259 - What is included in annual gross volume.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false What is included in annual gross volume. 779.259 Section... Coverage Annual Gross Volume of Sales Made Or Business Done § 779.259 What is included in annual gross volume. (a) The annual gross volume of sales made or business done of an enterprise consists of its...

  16. 77 FR 62265 - Long Elevator & Machine Company, Inc., Including Workers Whose Wages Were Reported Through Kone...

    Science.gov (United States)

    2012-10-12

    ... June 6, 2012 (77 FR 33490). The workers' firm was engaged in activities related to the supply of... Employment and Training Administration Long Elevator & Machine Company, Inc., Including Workers Whose Wages... Reconsideration for workers and former workers of Long Elevator & Machine Company, Inc., including workers...

  17. 76 FR 4724 - Polaris Industries, Including On-Site Leased Workers From Westaff and Supply Technologies...

    Science.gov (United States)

    2011-01-26

    ..., 2010 (75 FR 56143). At the request of the petitioner, the Department reviewed the certification for... Employment and Training Administration Polaris Industries, Including On-Site Leased Workers From Westaff and... Assistance on August 26, 2010, applicable to workers of Polaris Industries, including on-site leased...

  18. 75 FR 77666 - Polaris Industries, Including On-Site Leased Workers From Westaff and Supply Technologies...

    Science.gov (United States)

    2010-12-13

    ..., 2010 (75 FR 56143). At the request of the petitioner, the Department reviewed the certification for... Employment and Training Administration Polaris Industries, Including On-Site Leased Workers From Westaff and... Assistance on August 26, 2010, applicable to workers of Polaris Industries, including on-site leased...

  19. 49 CFR 238.209 - Forward end structure of locomotives, including cab cars and MU locomotives.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Forward end structure of locomotives, including... SAFETY STANDARDS Specific Requirements for Tier I Passenger Equipment § 238.209 Forward end structure of locomotives, including cab cars and MU locomotives. (a)(1) The skin covering the forward-facing end of...

  20. 38 CFR 17.255 - Applications for grants for programs which include construction projects.

    Science.gov (United States)

    2010-07-01

    ... specifications for the construction project, and where applicable, sufficient explanations of technical... for programs which include construction projects. 17.255 Section 17.255 Pensions, Bonuses, and... Applications for grants for programs which include construction projects. In addition to the documents...

  1. 42 CFR 137.327 - May multiple projects be included in a single construction project agreement?

    Science.gov (United States)

    2010-10-01

    ... construction project agreement? 137.327 Section 137.327 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF...-GOVERNANCE Construction Project Assumption Process § 137.327 May multiple projects be included in a single construction project agreement? Yes, a Self-Governance Tribe may include multiple projects in a...

  2. 45 CFR 286.75 - What must be included in the Tribal Family Assistance Plan?

    Science.gov (United States)

    2010-10-01

    ... to specific populations, including teen parents and individuals who are transitioning off TANF... reservation” areas, as defined at 45 CFR 20.1(r), or any areas beyond “near reservation” to be included in the...) The TFAP must identify the employment opportunities in and near the service area and the manner...

  3. 75 FR 4583 - In the Matter of: Certain Electronic Devices, Including Mobile Phones, Portable Music Players...

    Science.gov (United States)

    2010-01-28

    ... COMMISSION In the Matter of: Certain Electronic Devices, Including Mobile Phones, Portable Music Players, and... electronic devices, including mobile phones, portable music players, and computers, by reason of infringement... mobile phones, portable music players, or computers that infringe one or more of claims 1-12 of...

  4. To graduate or not to graduate: The case of Cape Verde. INCLUDE special report

    NARCIS (Netherlands)

    P.A.G. van Bergeijk (Peter)

    2015-01-01

    markdownabstractThis INCLUDE Special Report is based on the Development Research Seminar (DRS) ‘To graduate or not to graduate’ held on 19 June 2015. This pre-graduation seminar was co-organized by INCLUDE and the Institute of Social Studies of Erasmus University for the defence of the PhD thesis ‘S

  5. 7 CFR 330.302 - Domestic movements of earth (including soil), stone, etc.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Domestic movements of earth (including soil), stone...; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY PRODUCTS; GARBAGE Movement of Soil, Stone, And Quarry Products § 330.302 Domestic movements of earth (including soil), stone, etc. The interstate movement...

  6. 25 CFR 1000.162 - What is included in a self-governance compact?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What is included in a self-governance compact? 1000.162...-DETERMINATION AND EDUCATION ACT Negotiation Process for Annual Funding Agreements Negotiating A Self-Governance Compact § 1000.162 What is included in a self-governance compact? A model format for...

  7. 75 FR 55613 - General Motors Corporation, Renaissance Center, Including On-Site Leased Workers From Accretive...

    Science.gov (United States)

    2010-09-13

    ... on May 20, 2010 (75 FR 28299). At the request of the State agency, the Department reviewed the... Employment and Training Administration General Motors Corporation, Renaissance Center, Including On-Site... of General Motors Corporation, Renaissance Center, including on-site leased workers from...

  8. 20 CFR 404.1322 - Post-World War II service included.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Post-World War II service included. 404.1322... DISABILITY INSURANCE (1950- ) Wage Credits for Veterans and Members of the Uniformed Services Post-World War II Veterans § 404.1322 Post-World War II service included. Your service was in the active service...

  9. 25 CFR 30.115 - Which students' performance data must be included for purposes of AYP?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Which students' performance data must be included for... EDUCATION ADEQUATE YEARLY PROGRESS Assessing Adequate Yearly Progress § 30.115 Which students' performance data must be included for purposes of AYP? The performance data of all students assessed pursuant...

  10. An Initial Look at the Quality of Life of Malaysian Families That Include Children with Disabilities

    Science.gov (United States)

    Clark, M.; Brown, R.; Karrapaya, R.

    2012-01-01

    Background: While there is a growing body of literature in the quality of life of families that include children with disabilities, the majority of research has been conducted in western countries. The present study provides an initial exploration of the quality of life of Malaysian families that include children with developmental/intellectual…

  11. 77 FR 24514 - Certain Consumer Electronics, Including Mobile Phones and Tablets; Institution of Investigation...

    Science.gov (United States)

    2012-04-24

    ... COMMISSION Certain Consumer Electronics, Including Mobile Phones and Tablets; Institution of Investigation... consumer electronics, including mobile phones and tablets, by reason of infringement of certain claims of U... importation, or the sale within the United States after importation of certain consumer electronics,...

  12. 78 FR 48468 - Delphi Corporation, Electronics and Safety Division, Including On-Site Leased Workers From...

    Science.gov (United States)

    2013-08-08

    ... determination was published in the Federal Register on June 10, 2013 (Volume 78 FR Pages 34672-34674). At the... Employment and Training Administration Delphi Corporation, Electronics and Safety Division, Including On-Site... to workers of Delphi Corporation, Electronics and Safety Division, including on-site leased...

  13. 20 CFR 410.450 - Death due to pneumoconiosis, including statutory presumption.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Death due to pneumoconiosis, including... Death Due to Pneumoconiosis § 410.450 Death due to pneumoconiosis, including statutory presumption... at the time of his death, or whose death is determined to have been due to pneumoconiosis....

  14. 48 CFR 852.236-83 - Payments under fixed-price construction contracts (including NAS).

    Science.gov (United States)

    2010-10-01

    ...: (1) The contracting officer may retain funds: (i) Where the performance under the contract has been... 2002). If the specifications include guarantee period services, the contracting officer shall include... the contracting officer shall inform the contractor of the unsatisfactory performance, allowing...

  15. Resource and environmental factors should be included in economic analytical framework

    Institute of Scientific and Technical Information of China (English)

    金碚

    2009-01-01

    In the economic analysis framework,natural resources and environmental factors are included in the category of capital or land.Hence,the explanatory variables of the production function only include capital,labor and the residue term technology.Such framework may be designed for methodological reasons,but it is determined

  16. 34 CFR 607.11 - What must be included in individual development grant applications?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What must be included in individual development grant... (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STRENGTHENING INSTITUTIONS PROGRAM How Does an Institution Apply for a Grant? § 607.11 What must be included in individual development...

  17. 77 FR 3500 - Hugo Boss Cleveland, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Science.gov (United States)

    2012-01-24

    ... location of Hugo Boss Cleveland, Inc. had their wages reported under a separate unemployment insurance (UI...., including workers whose unemployment insurance (UI) wages are paid through TJFC Distribution, Brooklyn, Ohio... Employment and Training Administration Hugo Boss Cleveland, Inc., Including Workers Whose...

  18. 75 FR 43557 - Wire Products Company, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Science.gov (United States)

    2010-07-26

    ... unemployment insurance (UI) tax account under the name Globe Pipe Hanger Products, Inc. Based on these findings..., Inc., including workers whose unemployment insurance (UI) wages are paid through Globe Pipe Hanger... Employment and Training Administration Wire Products Company, Inc., Including Workers Whose...

  19. 75 FR 26793 - Fypon, Ltd., Parkersburg, WV, Including Workers Whose Unemployment Insurance, (UI) Wages Are Paid...

    Science.gov (United States)

    2010-05-12

    ... Leased Workers From Job1 USA, Including Workers Whose Unemployment Insurance, (UI) Wages Are Paid Through... subject firm had their wages reported under a separate unemployment insurance (UI) tax account under the... workers of Fypon, Ltd, including workers whose unemployment insurance (UI) wages are paid through...

  20. 77 FR 4368 - ArcelorMittal, Including Workers Whose Unemployment Insurance (UI) Wages Are Reported Through...

    Science.gov (United States)

    2012-01-27

    ... Employment and Training Administration ArcelorMittal, Including Workers Whose Unemployment Insurance (UI... unemployment insurance (UI) tax account under the name Mittal Steel USA, Inc. Based on these findings, the Department is amending this certification to include workers whose unemployment insurance (UI) wages...

  1. 41 CFR 105-68.220 - Are any procurement contracts included as covered transactions?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Are any procurement contracts included as covered transactions? 105-68.220 Section 105-68.220 Public Contracts and Property...) Covered Transactions § 105-68.220 Are any procurement contracts included as covered transactions?...

  2. Context Influences Preschool Children's Decisions to Include a Peer with a Physical Disability in Play

    Science.gov (United States)

    Diamond, Karen E.; Hong, Soo-Young; Tu, Huifang

    2008-01-01

    Understanding children's decisions to include a child with a disability in activities is an important component of the social environment of children with disabilities. We examined preschool children's understanding of the motor and social competence of hypothetical children with a physical disability, children's decisions to include or exclude a…

  3. 26 CFR 48.4216(a)-1 - Charges to be included in sale price.

    Science.gov (United States)

    2010-04-01

    ... sales promotion programs, or otherwise. With respect to the rules relating to exclusion (in the case of... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Charges to be included in sale price. 48.4216(a... to Manufacturers Taxes § 48.4216(a)-1 Charges to be included in sale price. (a) In general....

  4. 10 CFR 719.10 - What information must be included in the legal management plan?

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false What information must be included in the legal management plan? 719.10 Section 719.10 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS Legal Management Plan § 719.10 What information must be included in the legal management plan? The legal...

  5. Systems including catalysts in porous zeolite materials within a reactor for use in synthesizing hydrocarbons

    Science.gov (United States)

    Rolllins, Harry W.; Petkovic, Lucia M.; Ginosar, Daniel M.

    2012-07-24

    Catalytic structures include a catalytic material disposed within a zeolite material. The catalytic material may be capable of catalyzing a formation of methanol from carbon monoxide and/or carbon dioxide, and the zeolite material may be capable of catalyzing a formation of hydrocarbon molecules from methanol. The catalytic material may include copper and zinc oxide. The zeolite material may include a first plurality of pores substantially defined by a crystal structure of the zeolite material and a second plurality of pores dispersed throughout the zeolite material. Systems for synthesizing hydrocarbon molecules also include catalytic structures. Methods for synthesizing hydrocarbon molecules include contacting hydrogen and at least one of carbon monoxide and carbon dioxide with such catalytic structures. Catalytic structures are fabricated by forming a zeolite material at least partially around a template structure, removing the template structure, and introducing a catalytic material into the zeolite material.

  6. Methods of using structures including catalytic materials disposed within porous zeolite materials to synthesize hydrocarbons

    Science.gov (United States)

    Rollins, Harry W.; Petkovic, Lucia M.; Ginosar, Daniel M.

    2011-02-01

    Catalytic structures include a catalytic material disposed within a zeolite material. The catalytic material may be capable of catalyzing a formation of methanol from carbon monoxide and/or carbon dioxide, and the zeolite material may be capable of catalyzing a formation of hydrocarbon molecules from methanol. The catalytic material may include copper and zinc oxide. The zeolite material may include a first plurality of pores substantially defined by a crystal structure of the zeolite material and a second plurality of pores dispersed throughout the zeolite material. Systems for synthesizing hydrocarbon molecules also include catalytic structures. Methods for synthesizing hydrocarbon molecules include contacting hydrogen and at least one of carbon monoxide and carbon dioxide with such catalytic structures. Catalytic structures are fabricated by forming a zeolite material at least partially around a template structure, removing the template structure, and introducing a catalytic material into the zeolite material.

  7. Systems and strippable coatings for decontaminating structures that include porous material

    Energy Technology Data Exchange (ETDEWEB)

    Fox, Robert V. (Idaho Falls, ID); Avci, Recep (Bozeman, MT); Groenewold, Gary S. (Idaho Falls, ID)

    2011-12-06

    Methods of removing contaminant matter from porous materials include applying a polymer material to a contaminated surface, irradiating the contaminated surface to cause redistribution of contaminant matter, and removing at least a portion of the polymer material from the surface. Systems for decontaminating a contaminated structure comprising porous material include a radiation device configured to emit electromagnetic radiation toward a surface of a structure, and at least one spray device configured to apply a capture material onto the surface of the structure. Polymer materials that can be used in such methods and systems include polyphosphazine-based polymer materials having polyphosphazine backbone segments and side chain groups that include selected functional groups. The selected functional groups may include iminos, oximes, carboxylates, sulfonates, .beta.-diketones, phosphine sulfides, phosphates, phosphites, phosphonates, phosphinates, phosphine oxides, monothio phosphinic acids, and dithio phosphinic acids.

  8. New Nuclear Materials Including Non Metallic Fuel Elements. Vol. I. Proceedings of the Conference on New Nuclear Materials Technology, Including Non Metallic Fuel Elements

    International Nuclear Information System (INIS)

    One of the major aims of the International Atomic Energy Agency in furthering the peaceful uses of atomic energy is to encourage the development of economical nuclear power. Certainly, one of the more obvious methods of producing economical nuclear power is the development of economical fuels that can be used at high temperatures for long periods of time, and which have sufficient strength and integrity to operate under these conditions without permitting the release of fission products. In addition it is desirable that after irradiation these new fuels be economically reprocessed to reduce further the cost of the fuel cycle. As nuclear power becomes more and more competitive with conventional power the interest in new and more efficient higher-temperature fuels naturally increases rapidly. For these reasons, the Agency organized a Conference on New Nuclear Materials Technology, Including Non-Metallic Fuel Elements, which was held from 1 to 5 July 1963 at the International Hotel, Prague, with the assistance and co-operation of the Government of the Czechoslovak Socialist Republic. A total of 151 scientists attended, from 23 countries and 4 international organizations. The participants heard and discussed more than 60 scientific papers

  9. Jet engine nozzle exit configurations, including projections oriented relative to pylons, and associated systems and methods

    Science.gov (United States)

    Mengle, Vinod G. (Inventor); Thomas, Russell H. (Inventor)

    2012-01-01

    Nozzle exit configurations and associated systems and methods are disclosed. An aircraft system in accordance with one embodiment includes a jet engine exhaust nozzle having an internal flow surface and an exit aperture, with the exit aperture having a perimeter that includes multiple projections extending in an aft direction. Aft portions of individual neighboring projections are spaced apart from each other by a gap, and a geometric feature of the multiple can change in a monotonic manner along at least a portion of the perimeter. Projections near a support pylon and/or associated heat shield can have particular configurations, including greater flow immersion than other projections.

  10. Electrical machines and assemblies including a yokeless stator with modular lamination stacks

    Science.gov (United States)

    Qu, Ronghai; Jansen, Patrick Lee; Bagepalli, Bharat Sampathkumar; Carl, Jr., Ralph James; Gadre, Aniruddha Dattatraya; Lopez, Fulton Jose

    2010-04-06

    An electrical machine includes a rotor with an inner rotor portion and an outer rotor portion, and a double-sided yokeless stator. The yokeless stator includes modular lamination stacks and is configured for radial magnetic flux flow. The double-sided yokeless stator is concentrically disposed between the inner rotor portion and the outer rotor portion of the electrical machine. Examples of particularly useful embodiments for the electrical machine include wind turbine generators, ship propulsion motors, switch reluctance machines and double-sided synchronous machines.

  11. Turbomachine combustor nozzle including a monolithic nozzle component and method of forming the same

    Energy Technology Data Exchange (ETDEWEB)

    Stoia, Lucas John; Melton, Patrick Benedict; Johnson, Thomas Edward; Stevenson, Christian Xavier; Vanselow, John Drake; Westmoreland, James Harold

    2016-02-23

    A turbomachine combustor nozzle includes a monolithic nozzle component having a plate element and a plurality of nozzle elements. Each of the plurality of nozzle elements includes a first end extending from the plate element to a second end. The plate element and plurality of nozzle elements are formed as a unitary component. A plate member is joined with the nozzle component. The plate member includes an outer edge that defines first and second surfaces and a plurality of openings extending between the first and second surfaces. The plurality of openings are configured and disposed to register with and receive the second end of corresponding ones of the plurality of nozzle elements.

  12. New Nuclear Materials Including Non Metallic Fuel Elements. Vol. II. Proceedings of the Conference on New Nuclear Materials Technology, Including Non Metallic Fuel Elements

    International Nuclear Information System (INIS)

    One of the major aims of the International Atomic Energy Agency in furthering the peaceful uses of atomic energy is to encourage the development of economical nuclear power. Certainly, one of the more obvious methods of producing economical nuclear power is the development of economical fuels that can be used at high temperatures for long periods of time, and which have sufficient strength and integrity to operate under these conditions without permitting the release of fission products. In addition it is desirable that after irradiation these new fuels be economically reprocessed to reduce further the cost of the fuel cycle. As nuclear power becomes more and more competitive with conventional power the interest in new and more efficient higher-temperature fuels naturally increases rapidly. For these reasons, the Agency organized a Conference on New Nuclear Materials Technology, Including Non-Metallic Fuel Elements, which was held from 1 to 5 July 1963 at the International Hotel, Prague, with the assistance and co-operation of the Government of the Czechoslovak Socialist Republic. A total of 151 scientists attended, from 23 countries and 4 international organizations. The participants heard and discussed more than 60 scientific papers. The Agency wishes to thank the scientists who attended this Conference for their papers and for many spirited discussions that truly mark a successful meeting. The Agency wishes also to record its gratitude for the assistance and generous hospitality accorded the Conference, the participants and the Agency's staff by the Government of the Czechoslovak Socialist Republic and by the people of Prague. The scientific information contained in these Proceedings should help to quicken the pace of progress in the fabrication of new and m ore economical fuels, and it is hoped that these proceedings will be found useful to all workers in this and related fields

  13. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Science.gov (United States)

    2010-07-01

    ... policy, signed by the University's senior management, which must include commitments to regulatory...) Policies and procedures for managing environmental documents and records applicable to this Environmental... identified in the Environmental Management Plan must be informed of relevant policies, procedures or...

  14. 77 FR 38843 - Submission for OMB Review; Comment Request: Post-Award Reporting Requirements Including New...

    Science.gov (United States)

    2012-06-29

    ... as the official record of grantee relinquishment of a PHS award when an award is transferred from one..., including the use of appropriate automated, electronic, mechanical, or other technological...

  15. Map Service Showing Geology, Oil and Gas Fields, and Geologic Provinces of Europe including Turkey

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This digitally compiled map includes geology, oil and gas fields, and geologic provinces of Europe. The oil and gas map is part of a worldwide series released on...

  16. Selection Component Analysis of Natural Polymorphisms using Population Samples Including Mother-Offspring Combinations, II

    DEFF Research Database (Denmark)

    Jarmer, Hanne Østergaard; Christiansen, Freddy Bugge

    1981-01-01

    Population samples including mother-offspring combinations provide information on the selection components: zygotic selection, sexual selection, gametic seletion and fecundity selection, on the mating pattern, and on the deviation from linkage equilibrium among the loci studied. The theory...

  17. Electrode assemblies, plasma apparatuses and systems including electrode assemblies, and methods for generating plasma

    Science.gov (United States)

    Kong, Peter C; Grandy, Jon D; Detering, Brent A; Zuck, Larry D

    2013-09-17

    Electrode assemblies for plasma reactors include a structure or device for constraining an arc endpoint to a selected area or region on an electrode. In some embodiments, the structure or device may comprise one or more insulating members covering a portion of an electrode. In additional embodiments, the structure or device may provide a magnetic field configured to control a location of an arc endpoint on the electrode. Plasma generating modules, apparatus, and systems include such electrode assemblies. Methods for generating a plasma include covering at least a portion of a surface of an electrode with an electrically insulating member to constrain a location of an arc endpoint on the electrode. Additional methods for generating a plasma include generating a magnetic field to constrain a location of an arc endpoint on an electrode.

  18. 77 FR 59985 - Healthcare Corporation of America (HCA), HCA Mountain Division Including Workers Whose Wages Were...

    Science.gov (United States)

    2012-10-01

    ... Employment and Training Administration Healthcare Corporation of America (HCA), HCA Mountain Division... of Healthcare Corporation of America (HCA), HCA Mountain Division, Cottonwood Heights, Utah (subject... follows: All workers of Healthcare Corporation of America (HCA), HCA Mountain Division, including...

  19. Mathematical Model of Thyristor Inverter Including a Series-parallel Resonant Circuit

    Directory of Open Access Journals (Sweden)

    Miroslaw Luft

    2008-01-01

    Full Text Available The article presents a mathematical model of thyristor inverter including a series-parallel resonant circuit with theaid of state variable method. Maple procedures are used to compute current and voltage waveforms in the inverter.

  20. Differential two-body compound nuclear cross section, including the width-fluctuation corrections

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D. [Brookhaven National Lab. (BNL), Upton, NY (United States). NNDC; Herman, M. [Brookhaven National Lab. (BNL), Upton, NY (United States). NNDC

    2014-09-02

    We figure out the compound angular differential cross sections, following mainly Fröbrich and Lipperheide, but with the angular momentum couplings that make sense for optical model work. We include the width-fluctuation correction along with calculations.

  1. 75 FR 71458 - Cranberry Lumber Company Including Workers of the Following Operating Entities: Butternut One...

    Science.gov (United States)

    2010-11-23

    ... Notice was published in the Federal Register on August 13, 2010 (75 FR 49531). The workers are engaged in... include the afore-mentioned additional workers. The amended notice applicable to TA-W-73,910 is...

  2. 78 FR 34132 - Certain Portable Electronic Communications Devices, Including Mobile Phones and Components...

    Science.gov (United States)

    2013-06-06

    ... published a notice (78 FR 12892, May 31, 2013) of receipt of complaint entitled Certain Portable Electronic... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Portable Electronic Communications Devices, Including Mobile Phones and Components...

  3. 77 FR 4368 - Abbott Laboratories, Diagnostics Division, Including On-Site Leased Workers From Manpower...

    Science.gov (United States)

    2012-01-27

    ... Employment and Training Administration Abbott Laboratories, Diagnostics Division, Including On-Site Leased... for Worker Adjustment Assistance on February 24, 2011, applicable to workers of Abbott Laboratories... location of Abbott Laboratories, Diagnostics Division. The Department has determined that these...

  4. 76 FR 23812 - Reliability and Continuity of Communications Networks, Including Broadband Technologies; Effects...

    Science.gov (United States)

    2011-04-28

    ... COMMISSION Reliability and Continuity of Communications Networks, Including Broadband Technologies; Effects on Broadband Communications Networks of Damage or Failure of Network Equipment or Severe Overload; Independent Panel Reviewing the Impact of Hurricane Katrina on Communications Networks AGENCY:...

  5. Aids to Navigation for US waters, including territories, as of April 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Structures intended to assist a navigator to determine position or safe course, or to warn of dangers or obstructions to navigation. This dataset includes lights,...

  6. 30 CFR 250.415 - What must my casing and cementing programs include?

    Science.gov (United States)

    2010-07-01

    ... effect, proper anchorage, and well control. (e) A statement of how you evaluated the best practices included in API RP 65, Recommended Practice for Cementing Shallow Water Flow Zones in Deep Water...

  7. 40 CFR 62.14740 - What must I include in the deviation report?

    Science.gov (United States)

    2010-07-01

    ... POLLUTANTS Federal Plan Requirements for Commercial and Industrial Solid Waste Incineration Units That... include in the deviation report? In each report required under § 62.14735, for any pollutant or...

  8. Parcels and Land Ownership, Includes APN only, Published in 2007, Churchill County, NV.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Parcels and Land Ownership dataset, was produced all or in part from Published Reports/Deeds information as of 2007. It is described as 'Includes APN only'....

  9. Gage measures total radiation, including vacuum UV, from ionized high-temperature gases

    Science.gov (United States)

    Wood, A. D.

    1969-01-01

    Transient-heat transfer gage measures the total radiation intensity from vacuum ultraviolet and ionized high temperature gases. The gage includes a sensitive piezoelectric crystal that is completely isolated from any ionized flow and vacuum ultraviolet irradiation.

  10. 78 FR 69878 - First Advantage Corporation, Including On-Site Leased Workers From Tapfin, Staffworks, Aerotek...

    Science.gov (United States)

    2013-11-21

    ... Employment and Training Administration First Advantage Corporation, Including On-Site Leased Workers From... Staffing, St. Petersburg, Florida; First Advantage Corporation, Charlotte, North Carolina, First Advantage Corporation, Bolingbrook, Illinois; First Advantage Corporation, Dallas, Texas; First Advantage...

  11. 75 FR 49526 - Halliburton Company, Duncan Mfg., Including On-Site Leased Workers from Express Personnel...

    Science.gov (United States)

    2010-08-13

    ... Employment and Training Administration Halliburton Company, Duncan Mfg., Including On-Site Leased Workers... Company, Technology and Engineering Division, Finance and Administration Division, Duncan, OK; Amended.... Workers of Halliburton Company, Technology and Engineering Division, and Finance and...

  12. 77 FR 34063 - Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof...

    Science.gov (United States)

    2012-06-08

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Electronic Devices, Including Mobile Phones and Tablet Computers, and Components Thereof Institution of Investigation AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice...

  13. 75 FR 448 - In the Matter of: Certain Authentication Systems, Including Software and Handheld Electronic...

    Science.gov (United States)

    2010-01-05

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of: Certain Authentication Systems, Including Software and Handheld Electronic Devices; Notice of Investigation AGENCY: U.S. International Trade Commission. ACTION: Institution...

  14. 75 FR 10502 - In the Matter of Certain Electronic Devices, Including Handheld Wireless Communications Devices...

    Science.gov (United States)

    2010-03-08

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of Certain Electronic Devices, Including Handheld Wireless Communications Devices... in Their Entirety AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice...

  15. 78 FR 1247 - Certain Electronic Devices, Including Wireless Communication Devices, Tablet Computers, Media...

    Science.gov (United States)

    2013-01-08

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Electronic Devices, Including Wireless Communication Devices, Tablet Computers, Media... Code AGENCY: U.S. International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given...

  16. 78 FR 38361 - Certain Portable Electronic Communications Devices, Including Mobile Phones and Components...

    Science.gov (United States)

    2013-06-26

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Portable Electronic Communications Devices, Including Mobile Phones and Components Thereof; Institution of Investigation Pursuant to United States Code AGENCY: U.S. International Trade...

  17. 75 FR 34170 - Circuit Science, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Science.gov (United States)

    2010-06-16

    ... Employment and Training Administration Circuit Science, Inc., Including Workers Whose Unemployment Insurance... subject firm had their wages reported under a separated unemployment insurance (UI) tax account under the... workers whose unemployment insurance (UI) wages are reported through Circuit, Plymouth, Minnesota,...

  18. 75 FR 52981 - Bluescope Buildings North America, Including Workers Whose Unemployment Insurance (UI) Wages Are...

    Science.gov (United States)

    2010-08-30

    ... Unemployment Insurance (UI) Wages Are Reported Through Butler Manufacturing Company, Laurinburg, NC; Amended...Scope Buildings North America had their wages reported through a separate unemployment insurance (UI... America, including workers whose unemployment insurance (UI) wages are reported through...

  19. 75 FR 20387 - Contech Castings, LLC, Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Science.gov (United States)

    2010-04-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Contech Castings, LLC, Including Workers Whose Unemployment Insurance... subject firm had their wages reported under a separate unemployment insurance (UI) tax account under...

  20. 75 FR 24748 - Johnson Controls, Inc., Automotive Experience Division, Including Workers Whose Unemployment...

    Science.gov (United States)

    2010-05-05

    ... Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Hoover Universal, Greenfield, OH; Amended... their wages reported under a separate unemployment insurance (UI) tax account, under the name Hoover..., Inc., Automotive Experience Division, including workers whose unemployment insurance (UI) wages...

  1. 76 FR 27366 - Blue Heron Paper Company, Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Science.gov (United States)

    2011-05-11

    ... reported under a separated unemployment insurance (UI) tax account under the name Barrett Business Services... Employment and Training Administration Blue Heron Paper Company, Including Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Barrett Business Services, Inc., Oregon City, OR;...

  2. U.S. Coastal Lidar Elevation Data - Including the Great Lakes and Territories, 1996 - present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Services Center manages and distributes lidar data for the coastal United States, including territorial possessions via the Digital Coast Data...

  3. 77 FR 3793 - Certain Liquid Crystal Display Devices, Including Monitors, Televisions, and Modules, and...

    Science.gov (United States)

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Liquid Crystal Display Devices, Including Monitors, Televisions, and Modules, and Components Thereof; Request for Statements on the Public Interest AGENCY: U.S. International Trade...

  4. 75 FR 60141 - International Business Machines (IBM), Global Technology Services Delivery Division, Including On...

    Science.gov (United States)

    2010-09-29

    ... Employment and Training Administration International Business Machines (IBM), Global Technology Services... of International Business Machines (IBM), Global Technology Services Delivery Division, Greenville... International Business Machines (IBM), Global Technology Services Delivery Division, including on-site...

  5. Social-pragmatic skills of deaf and hard of hearing preschool children (included in kindergarden)

    OpenAIRE

    Vidmar, Barbara

    2015-01-01

    Since more and more children with special needs are included in preschool programs, educators are more often in contact with deaf and partially deaf children. They have to provide optimal conditions for their development. The graduate thesis titled Sociopragmatic skills of hearing, deaf and partially deaf preschool children included in the kindergarten is focused on possible differences in sociopragmatic skills of the hearing and the deaf and partially deaf children. It consists of a theoreti...

  6. High-Resolution Panchromatic Spectral Models of Galaxies including Photoionisation and Dust

    OpenAIRE

    Jonsson, Patrik; Groves, Brent; Cox, T. J.

    2009-01-01

    An updated version of the dust radiation transfer code Sunrise, including models for star-forming regions and a self-consistent calculation of the spatially dependent dust and PAH emission, is presented. Given a hydrodynamic simulation of a galaxy, this model can calculate a realistic 2-dimensional ultraviolet--submillimeter spectral energy distribution of the galaxy, including emission lines from HII regions, from any viewpoint. To model the emission from star-forming regions, the MAPPINGSII...

  7. Assumptions for Including Organic Food in the Gastronomic Offering of Istrian Agritourism

    OpenAIRE

    Pavlo Ružić; Ivana Medica

    2009-01-01

    The authors of this research analyze assumptions to including organic food in the gastronomic offering of Istrians agritourism. They assume that gastronomic offering of Istrian agritourism that includes organic food would be more acceptable and competitive on the tourist market. The authors analyzed their assumptions using surveys conducted in 2007 and 2008 on tourists in Istra to learn whether they prefer organic food, does organic food match modern tourist trends, and are they willing to pa...

  8. Assumptions for Including Organic Food in the Gastronomic Offering of Istrian Agritourism

    Directory of Open Access Journals (Sweden)

    Pavlo Ružić

    2009-01-01

    Full Text Available The authors of this research analyze assumptions to including organic food in the gastronomic offering of Istrians agritourism. They assume that gastronomic offering of Istrian agritourism that includes organic food would be more acceptable and competitive on the tourist market. The authors analyzed their assumptions using surveys conducted in 2007 and 2008 on tourists in Istra to learn whether they prefer organic food, does organic food match modern tourist trends, and are they willing to pay more for it.

  9. Anàlisi de la dimensió de gènere en el marc del projecte INCLUD-ED per a desenvolupar pràctiques educatives inclusives Analysis of gender aspects in the framework of the INCLUD-ED project to develop inclusive educational practices Análisis de la dimensión de género en el marco del proyecto INCLUD-ED para desarrollar prácticas educativas inclusivas

    Directory of Open Access Journals (Sweden)

    Patricia Melgar

    2010-01-01

    ésultats académiquesVarious aspects, including gender, must be considered to boost the inclusivity of education. The risk of social exclusion may increase when gender is combined with other factors such as the cultural group, age or low socioeconomic level. Some studies have shown that there has been a significant improvement in girls’ academic results, which are better than those of boys in certain areas. However, the contribution of such studies is limited, as they describe the situation without examining its causes in-depth. This has led to new debates in the scientific community. The power relationships between the genders and the transmission traditional models of masculinity and femininity that can still be found in some school practices today have an impact on academic results.La promoción de la dimensión integradora de la educación debe contemplar las diferentes perspectivas, entre ellas la de género. El riesgo de exclusión social puede aumentar cuando la dimensión de género se combina con otras dimensiones como el grupo cultural, la edad o el bajo nivel socioeconómico. Algunos estudios indican que se ha producido una mejora significativa en los resultados académicos de las niñas, superando incluso los resultados de los niños en determinadas áreas. No obstante, las contribuciones aportadas son limitadas ya que describen la situación sin profundizar en las causas que llevan a esta situación. Ello ha reabierto recientemente nuevos debates en el marco de la comunidad científica. Las relaciones de poder entre género, así como la transmisión de modelos tradicionales de masculinidad y feminidad, que todavía se pueden observar hoy en día en algunas prácticas en las escuelas, tienen un impacto en los resultados académicos.

  10. Isospin mixing within relativistic mean-field models including the delta meson

    International Nuclear Information System (INIS)

    Full text: We investigate isospin mixing effects in the asymmetry as obtained in parity-violating electron scattering for selected spherical nuclei ranging from 4He to 208Pb. The scattering analysis is developed within plane and distorted wave Born approximations (PWBA and DWBA) accounting for nucleon form factors, which are given by the Galster parametrization. We use Walecka's Model (QHD), including the σ, ω, ρ and δ mesons as well as the electromagnetic interaction. The ρ meson effects are specially interesting once it should add a contribution for isospin mixing together with the electromagnetic and meson fields. Our model includes Lagrangians with non-linear terms as well as Lagrangians including density dependent couplings. The model is solved in a Hartree approximation with spherical symmetry using a self-consistent calculation by means of an expansion of the nuclear wave functions and potentials in an harmonic oscillator basis. For each kind of Lagrangian we use two different parametrizations, one including the ρ meson and another in which it is not included. In this way, the effects of the inclusion of that meson can be inferred. For non-linear Lagrangians, the NL3 and NLδparameter sets are used. For Lagrangians with density dependent couplings, the TW and a reparametrization of the DDHδ, modified to better reproduce the main nuclear properties, are used. (author)

  11. Processing negative valence of word pairs that include a positive word.

    Science.gov (United States)

    Itkes, Oksana; Mashal, Nira

    2016-09-01

    Previous research has suggested that cognitive performance is interrupted by negative relative to neutral or positive stimuli. We examined whether negative valence affects performance at the word or phrase level. Participants performed a semantic decision task on word pairs that included either a negative or a positive target word. In Experiment 1, the valence of the target word was congruent with the overall valence conveyed by the word pair (e.g., fat kid). As expected, response times were slower in the negative condition relative to the positive condition. Experiment 2 included target words that were incongruent with the overall valence of the word pair (e.g., fat salary). Response times were longer for word pairs whose overall valence was negative relative to positive, even though these word pairs included a positive word. Our findings support the Cognitive Primacy Hypothesis, according to which emotional valence is extracted after conceptual processing is complete. PMID:26008637

  12. Coupled flexural-torsional vibration band gap in periodic beam including warping effect

    Institute of Scientific and Technical Information of China (English)

    Fang Jian-Yu; Yu Dian-Long; Han Xiao-Yun; Cai Li

    2009-01-01

    The propagation of coupled flexural-torsional vibration in the periodic beam including warping effect is investigated with the transfer matrix theory.The band structures of the periodic beam,both including warping effect and ignoring warping effect,are obtained.The frequency response function of the finite periodic beams is simulated with finite element method,which shows large vibration attenuation in the frequency range of the gap as expected.The effect of warping stiffness on the band structure is studied and it is concluded that substantial error can be produced in high frequency range if the effect is ignored.The result including warping effect agrees quite well with the simulated result.

  13. Deliverable 4.2: Methodology for including specific biological effects and pathogen aspects into LCA

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Olsen, Stig Irving; Hauschild, Michael Zwicky;

    2009-01-01

    As described in deliverable 4.1 (Larsen et al. 2007) NEPTUNE is using two main types of life cycle impact assessment (LCIA) methodologies when doing LCA studies on the waste water treatment technologies included. The basic methodology is the well known existing EDIP97 methodology (Wenzel et al....... 1997, Hauschild and Wenzel 1998) for which the impact assessment on toxicity is PNEC based. However, in order to include the newest development on especially best available practice as regards ecotoxicity a new revised and updated EDIP 200X LCIA methodology has been developed. A first draft...... of this methodology is presented here. Furthermore, special issues related to waste water have been addressed by including novel development on LCIA methodology for possible impact from pathogens and whole effluent toxicity. Special focus is also allocated to micropollutants with specific toxic mode of action (i...

  14. Cleanup and treatment of radioactively contaminated land including areas near nuclear facilities. A selected bibliography

    International Nuclear Information System (INIS)

    This annotated bibliography of 337 references summarizes the literature published on the cleanup and treatment of radioactively contaminated land. Specifically, this bibliography focuses on literature concerned with the methods of cleanup and treatment being applied - chemical, physical, or vegetative stabilization; the types of equipment being used; and the influence of climatic conditions on the method selected for use. The emphasis in such literature is placed on hazardous site cleanup efforts that have been completed as well as those that are in progress and are being planned. Appendix A includes 135 additional references to literature identified but not included in the bibliography because of time and funding constraints. Appendix B consists of a table that identifies the cleanup and treatment research conducted at specific sites. All of the information included in this bibliography is stored in a computerized form that is readily available upon request

  15. Alcohol intake and colorectal cancer: a comparison of approaches for including repeated measures of alcohol consumption

    DEFF Research Database (Denmark)

    Thygesen, Lau Caspar; Wu, Kana; Grønbaek, Morten;

    2008-01-01

    BACKGROUND: In numerous studies, alcohol intake has been found to be positively associated with colorectal cancer risk. However, the majority of studies included only one exposure measurement, which may bias the results if long-term intake is relevant.METHODS: We compared different approaches...... for including repeated measures of alcohol intake among 47,432 US men enrolled in the Health Professionals Follow-up Study. Questionnaires including questions on alcohol intake had been completed in 1986, 1990, 1994, and 1998. The outcome was incident colorectal cancer during follow-up from 1986 to 2002.RESULTS......: During follow-up, 868 members of the cohort experienced colorectal cancer. Baseline, updated, and cumulative average alcohol intakes were positively associated with colorectal cancer, with only minor differences among the approaches. These results support moderately increased risk for intake >30 g...

  16. Including chemical-related impact categories in LCA on printed matter does it matter?

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Hansen, Morten Søes; Hauschild, Michael Zwicky

    2004-01-01

    Introduction Existing product Life Cycle Assessments (LCA¡¦s) on offset printed matter all point at paper as the overall dominating contributor to the impacts from the life-cycle of this category of products. This dominating role of paper is primarily founded in the energy-related impact categories...... global warming, acidification and nutrification. The studies focus on energy consumption including the emissions and impact categories related to energy. The chemical-related impact categories comprising ecotoxicity and human toxicity are not included at all or only to a limited degree. In this paper we...... include these chemical-related impact categories by making use of some of the newest knowledge about emissions from the production at the printing industry combined with knowledge about the composition of the printing materials used during the production of offset printed matter. This paper is based...

  17. EXACT SOLUTIONS FOR NONLINEAR TRANSIENT FLOW MODEL INCLUDING A QUADRATIC GRADIENT TERM

    Institute of Scientific and Technical Information of China (English)

    曹绪龙; 同登科; 王瑞和

    2004-01-01

    The models of the nonlinear radial flow for the infinite and finite reservoirs including a quadratic gradient term were presented. The exact solution was given in real space for flow equation including quadratic gradiet term for both constant-rate and constant pressure production cases in an infinite system by using generalized Weber transform. Analytical solutions for flow equation including quadratic gradient term were also obtained by using the Hankel transform for a finite circular reservoir case. Both closed and constant pressure outer boundary conditions are considered. Moreover, both constant rate and constant pressure inner boundary conditions are considered. The difference between the nonlinear pressure solution and linear pressure solution is analyzed. The difference may be reached about 8% in the long time. The effect of the quadratic gradient term in the large time well test is considered.

  18. [Significance of Multi-center Obstetrics Perioperative Team Training Including Various Medical Staffs].

    Science.gov (United States)

    Komasawa, Nobuyasu; Fujita, Daisuke; Nakayama, Mai; Fujiwara, Shunsuke; Mihara, Ryosuke; Okada, Daisuke; Omoto, Haruka; Tanaka, Motoshige; Nishihara, Isao; Minami, Toshiaki

    2016-02-01

    We report the development of a multi-center/multispecialist obstetrics perioperative team training program. Participants were members of the team, including anesthesiologists, obstetricians, and operation nurses. A questionnaire survey was conducted prior to course participation to clarify any questions team members had. The courses included a lecture and simulation training with scenario-based discussions or the use of a simulator. Scenarios included massive bleeding during cesarean section, massive bleeding after vaginal delivery, and emergency cesarean section for premature placental abruption. After each course, participants discussed problems associated with obstetrics medical safety in the context of each theme. Simulation-based perioperative team training with anesthesiologists, obstetricians, and operation nurses may serve as a vehicle to promote perioperative obstetrics patient safety.

  19. An approach to include soil carbon changes in life cycle assessments

    DEFF Research Database (Denmark)

    Petersen, Bjorn Molt; Knudsen, Marie Trydeman; Hermansen, John Erik;

    2013-01-01

    to estimate carbon sequestration to be included in LCA is suggested and applied to two examples where the inclusion of carbon sequestration is especially relevant: 1) Bioenergy: removal of straw from a Danish soil for energy purposes and 2) Organic versus conventional farming: comparative study of soybean......Globally, soil carbon sequestration is expected to hold a major potential to mitigate agricultural greenhouse gas emissions. However, the majority of life cycle assessments (LCA) of agricultural products have not included possible changes in soil carbon sequestration. In the present study, a method...... production in China. The suggested approach considers the time of the soil CO2 emissions for the LCA by including the Bern Carbon Cycle Model. Time perspectives of 20,100 and 200 years are used and a soil depth of 0-100 cm is considered. The application of the suggested method showed that the results were...

  20. Force measuring valve assemblies, systems including such valve assemblies and related methods

    Science.gov (United States)

    DeWall, Kevin George; Garcia, Humberto Enrique; McKellar, Michael George

    2012-04-17

    Methods of evaluating a fluid condition may include stroking a valve member and measuring a force acting on the valve member during the stroke. Methods of evaluating a fluid condition may include measuring a force acting on a valve member in the presence of fluid flow over a period of time and evaluating at least one of the frequency of changes in the measured force over the period of time and the magnitude of the changes in the measured force over the period of time to identify the presence of an anomaly in a fluid flow and, optionally, its estimated location. Methods of evaluating a valve condition may include directing a fluid flow through a valve while stroking a valve member, measuring a force acting on the valve member during the stroke, and comparing the measured force to a reference force. Valve assemblies and related systems are also disclosed.

  1. Improvement of prediction ability for genomic selection of dairy cattle by including dominance effects.

    Directory of Open Access Journals (Sweden)

    Chuanyu Sun

    Full Text Available Dominance may be an important source of non-additive genetic variance for many traits of dairy cattle. However, nearly all prediction models for dairy cattle have included only additive effects because of the limited number of cows with both genotypes and phenotypes. The role of dominance in the Holstein and Jersey breeds was investigated for eight traits: milk, fat, and protein yields; productive life; daughter pregnancy rate; somatic cell score; fat percent and protein percent. Additive and dominance variance components were estimated and then used to estimate additive and dominance effects of single nucleotide polymorphisms (SNPs. The predictive abilities of three models with both additive and dominance effects and a model with additive effects only were assessed using ten-fold cross-validation. One procedure estimated dominance values, and another estimated dominance deviations; calculation of the dominance relationship matrix was different for the two methods. The third approach enlarged the dataset by including cows with genotype probabilities derived using genotyped ancestors. For yield traits, dominance variance accounted for 5 and 7% of total variance for Holsteins and Jerseys, respectively; using dominance deviations resulted in smaller dominance and larger additive variance estimates. For non-yield traits, dominance variances were very small for both breeds. For yield traits, including additive and dominance effects fit the data better than including only additive effects; average correlations between estimated genetic effects and phenotypes showed that prediction accuracy increased when both effects rather than just additive effects were included. No corresponding gains in prediction ability were found for non-yield traits. Including cows with derived genotype probabilities from genotyped ancestors did not improve prediction accuracy. The largest additive effects were located on chromosome 14 near DGAT1 for yield traits for both

  2. Sensorless Speed Control including zero speed of Non Salient PM Synchronous Drives

    DEFF Research Database (Denmark)

    Rasmussen, Henrik

    This paper presents a position sensorless drive of non salient pole PM synchronous motors for all speeds including zero speed. Using adaptive Lyapunov design a new approach for the design of an observer is developed. The resulting scheme leads to a nonlinear full order observer for the motor states...... including the rotor speed. Assuming motor parameters known the design achieves stability with guaranteed region of attraction even at zero speed. The control method is made robust at zero and low speed by changing the direct vector current component to a value different from zero. In order to verify...

  3. Sensorless speed Control including Zero Speed on Non Salient PM Synchronous Drives

    DEFF Research Database (Denmark)

    Rasmussen, Henrik

    2006-01-01

    This paper presents a position sensorless drive of non salient pole PM synchronous motors for all speeds including zero speed. Using adaptive Lyapunov design a new approach for the design of an observer is developed. The resulting scheme leads to a nonlinear full order observer for the motor states...... including the rotor speed. Assuming motor parameters known the design achieves stability with guaranteed region of attraction even at zero speed. The control method is made robust at zero and low speed by changing the direct vector current component to a value different from zero. In order to verify...

  4. Sensorless Speed Control including zero speed of Non Salient PM Synchronous Drives

    DEFF Research Database (Denmark)

    Rasmussen, Henrik

    2005-01-01

    This paper presents a position sensorless drive of non salient pole PM synchronous motors for all speeds including zero speed. Using adaptive Lyapunov design a new approach for the design of an observer is developed. The resulting scheme leads to a nonlinear full order observer for the motor states...... including the rotor speed. Assuming motor parameters known the design achieves stability with guaranteed region of attraction even at zero speed. The control method is made robust at zero and low speed by changing the direct vector current component to a value different from zero. In order to verify...

  5. Health aspects of disaster preparedness and response--panel session 2: seismic risks including tsunamis.

    Science.gov (United States)

    2006-01-01

    This Panel Session consisted of five country reports (India, Indonesia, Maldives, Thailand, and Nepal) and the common issues identified during the Panel discussions relative to seismic events in the Southeast Asia Region. Important issues identified included the needs for: (1) a legal framework upon which to base preparedness and response; (2) coordination between the many organizations involved; (3) early warning systems within and between countries; (4) command and control; (5) access to resources including logistics; (6) strengthening the health infrastructure; (7) professionalizing the field of disaster medicine and management; (8) management of communications and information; (9) management of dead bodies; and (10) mental health of the survivors and health workers. PMID:17297912

  6. Environmental radioactivity in the North Atlantic region including the Faroe Islands and Greenland. 1990 and 1991

    International Nuclear Information System (INIS)

    Measurements of fallout radioactivity in the North Atlantic region including Faroe Islands and Greenland are reported. Strontium-90, cesium-137 and cesium-134 were determined in samples of precipitation, sea water, vegetation, various foodstuffs (including milk in the Faroes), and drinking water. Estimates are given of the mean contents of 90Sr and 137Cs in human diet in the Faroes and Greenland in 1990 and 1991. 99Tc data on marine samples, in particular sea water from the Greenland Sea, are reported. (au) (77 tabs., 46 ills., 8 refs.)

  7. [Examples of textual research on gynecological literature included in Yong le da dian (Yongle's Great Canon)].

    Science.gov (United States)

    Zhang, Xue-dan; Zhang, Ru-qing

    2010-07-01

    Yongle's Great Canon is a series of books to be read exclusively by the emperors of the Ming Dynasty, so all of the books included are from many rare books collected in Wen Yuan Ge of early Ming Dynasty. These rare books, ranging from Song, Jin, and Yuan Dynasties or from folk sources preserve the original appearance of the ancient books almost without any changes. From a philological viewpoint, the gynecological books included in Yong le da dian are studied, proof-read and checked for its lost texts and different texts. This can serve as a basis for the reprinting and re-publishing of ancient TCM books. PMID:21122346

  8. Sighting optics including an optical element having a first focal length and a second focal length

    Science.gov (United States)

    Crandall, David Lynn

    2011-08-01

    One embodiment of sighting optics according to the teachings provided herein may include a front sight and a rear sight positioned in spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus, for a user, images of the front sight and the target.

  9. Method for including detailed evaluation of daylight levels in Be06

    DEFF Research Database (Denmark)

    Petersen, Steffen

    2008-01-01

    . In order to evaluate whether a certain design is good daylight design or not building designers must perform detailed evaluation of daylight levels, including the daylight performance of dynamic solar shadings, and include these in the energy performance evaluation. However, the mandatory national...... for electrical lighting by 30% compared to the method suggested in this paper, which is based on hourly calculated illuminance levels in a representative point in the workspace. Implementing the suggested method in Be06 would be a better representation of the reality compared to the current method. Furthermore...

  10. Including 'positive handling strategies' within training in behaviour management: the 'Team-Teach' approach

    OpenAIRE

    Hayden, Carol; S. Pike

    2005-01-01

    This article reports on aspects of an evaluation of ‘Team-Teach’ - a ‘whole setting holistic’ approach to behaviour management in a range of child-care environments. A distinctive feature of Team-Teach is that it includes both training in de-escalation skills and physical interventions, known as ‘positive handling strategies’. The approach is clearly structured and calibrated against level of risk. It includes accreditation and re-accreditation of trainers. Findings from four case study educa...

  11. A note on communicating between information systems based on including degrees

    CERN Document Server

    Zhu, Ping

    2010-01-01

    In order to study the communication between information systems, Gong and Xiao [Z. Gong and Z. Xiao, Communicating between information systems based on including degrees, International Journal of General Systems 39 (2010) 189--206] proposed the concept of general relation mappings based on including degrees. Some properties and the extension for fuzzy information systems of the general relation mappings have been investigated there. In this paper, we point out by counterexamples that several assertions (Lemma 3.1, Lemma 3.2, Theorem 4.1, and Theorem 4.3) in the aforementioned work are not true in general.

  12. Environmental radioactivity in the North Atlantic region including the Faroe Islands and Greenland. 1987

    International Nuclear Information System (INIS)

    Measurements of fallout radioactivity in the North Atlantic region including the Faroe Islands and Greenland are reported. Strontium-90, cesium-137 and cesium-134 were determined in samples of precipitation, sea water, vegetation, various foodstuffs (including milk in the Faroes), and drinking water. Estimates are given of the mean contents of 90Sr and 137Cs in human diet in the Faroes and Greenland in 1987. 99Tc data on marine samples are reported. Data on plutonium and americium in sediments and biota collected at Thule in 1984 are presented. (author) 102 tabs., 35 ills., 15 refs

  13. Consideration of Including Male Circumcision in the Indonesian HIV Prevention Strategy

    Directory of Open Access Journals (Sweden)

    IN Sutarsa

    2015-04-01

    Full Text Available Introduction HIV/AIDS is an emerging threat to population health. Globally, 33.4 million people were estimated to be living with HIV in 2008 including 2.1 million children.1,2 The total number of new cases was estimated to be 2.7 million people (including 430,000 children and HIV/AIDS related death was estimated to be 2.0 million in 2008.1 Sustainable prevention measures followed by care, support and treatment program is vital to reduce the incidence and prevalence of HIV/AIDS.

  14. Including the Z in an Effective Field Theory for dark matter at the LHC

    OpenAIRE

    Davidson, Sacha

    2014-01-01

    An Effective Field Theory for dark matter at a TeV-scale hadron collider should include contact interactions of dark matter with the partons, the Higgs and the Z . This note estimates the impact of including dark matter- Z interactions on the complementarity of spin dependent direct detection and LHC monojet searches for dark matter. The effect of the Z is small, because it interacts with quarks via small electroweak couplings, and the contact interaction self-consistency condition C /Λ 2  

  15. Hot DA white dwarf model atmosphere calculations: Including improved Ni PI cross sections

    CERN Document Server

    Preval, S P; Badnell, N R; Hubeny, I; Holberg, J B

    2016-01-01

    To calculate realistic models of objects with Ni in their atmospheres, accurate atomic data for the relevant ionization stages needs to be included in model atmosphere calculations. In the context of white dwarf stars, we investigate the effect of changing the Ni {\\sc iv}-{\\sc vi} bound-bound and bound-free atomic data has on model atmosphere calculations. Models including PICS calculated with {\\sc autostructure} show significant flux attenuation of up to $\\sim 80$\\% shortward of 180\\AA\\, in the EUV region compared to a model using hydrogenic PICS. Comparatively, models including a larger set of Ni transitions left the EUV, UV, and optical continua unaffected. We use models calculated with permutations of this atomic data to test for potential changes to measured metal abundances of the hot DA white dwarf G191-B2B. Models including {\\sc autostructure} PICS were found to change the abundances of N and O by as much as $\\sim 22$\\% compared to models using hydrogenic PICS, but heavier species were relatively unaf...

  16. 37 CFR 1.18 - Patent post allowance (including issue) fees.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Patent post allowance (including issue) fees. 1.18 Section 1.18 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES General Provisions...

  17. 77 FR 36291 - Certain Communication Equipment, Components Thereof, and Products Containing the Same, Including...

    Science.gov (United States)

    2012-06-18

    ... products containing the same, including power over ethernet telephones, switches, wireless access points, routers and other devices used in LANs, and cameras. 76 FR 76,436-37 (Dec. 7, 2011). The complaint alleges... Power Over Ethernet Telephones, Switches, Wireless Access Points, Routers and Other Devices Used in...

  18. A revision of the genus Osmoxylon (Araliaceae) in Palau, including two new species.

    Science.gov (United States)

    Costion, Craig M; Plunkett, Gregory M

    2016-01-01

    Osmoxylon Miq. (Araliaceae) is revised for Palau, Micronesia including descriptions of two new taxa Osmoxylon leidichii Costion, sp. nov. and Osmoxylon ngardokense Costion, sp. nov. Full descriptions are provided for all four Palau species, along with diagnostic field keys. PMID:26884705

  19. 31 CFR 20.205 - What must I include in my drug-free workplace statement?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false What must I include in my drug-free workplace statement? 20.205 Section 20.205 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Other Than Individuals § 20.205...

  20. 31 CFR 20.215 - What must I include in my drug-free awareness program?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false What must I include in my drug-free awareness program? 20.215 Section 20.215 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Other...

  1. Elementary Contraceptive Information to be Included in Beijing’s Middle School Textbooks

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    From September this year, trial editions of Sex Health Guidance for Senior Middle School Students, and Sex Health Guidance for Junior Middle School Students, will be used in several schools in Haidian District, Beijing. Haidian Education Commission has sent out notices to all middle schools in the district, including secondary specialized schools,

  2. Histological findings in unclassified sudden infant death, including sudden infant death syndrome

    NARCIS (Netherlands)

    G. Liebrechts-Akkerman (Germaine); J.V.M.G. Bovée (Judith V. M. G.); L.C.D. Wijnaendts (Liliane); A. Maes (Ann); P.G.J. Nikkels (Peter); R.R. de Krijger (Ronald)

    2013-01-01

    textabstractOur objective was to study histological variations and abnormalities in unclassified sudden infant death (USID), including sudden infant death syndrome (SIDS), in The Netherlands. Two hundred Dutch USID cases between 1984 and 2005 were identified. The histology slides and autopsy reports

  3. Histological Findings in Unclassified Sudden Infant Death, Including Sudden Infant Death Syndrome

    NARCIS (Netherlands)

    Liebrechts-Akkerman, Germaine; Bovee, Judith V. M. G.; Wijnaendts, Liliane C. D.; Maes, Ann; Nikkels, Peter G. J.; de Krijger, Ronald R.

    2013-01-01

    Our objective was to study histological variations and abnormalities in unclassified sudden infant death (USID), including sudden infant death syndrome (SIDS), in The Netherlands. Two hundred Dutch USID cases between 1984 and 2005 were identified. The histology slides and autopsy reports of 187 case

  4. 75 FR 47631 - Douglas Battery Manufacturing Co., Currently Known as Lexington Road Properties, Inc., Including...

    Science.gov (United States)

    2010-08-06

    ... notice was published in the Federal Register February 16, 2010 (75 FR 7036). At the request of the State... Employment and Training Administration Douglas Battery Manufacturing Co., Currently Known as Lexington Road... January 6, 2010, applicable to workers of Douglas Battery Manufacturing Co., including on-site...

  5. Ab initio calculation of the bcc Fe-Al phase diagram including magnetic interactions

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales-Ormeno, Pablo Guillermo [Facultad de Ciencias Naturales y Matematica, Universidad Nacional Federico Villarreal, Calle San Marcos 351, Pueblo Libre, Lima (Peru); Departamento de Fisica dos Materiais e Mecanica, Instituto de Fisica da Universidade de Sao Paulo, CP 66318, CEP 05315-970 Sao Paulo-SP (Brazil); Computational Materials Science Lab., Departamento de Engenharia Metalurgica e de Materiais, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Mello Moraes, 2463, CEP 05508-900 Sao Paulo-SP (Brazil); Petrilli, Helena Maria [Departamento de Fisica dos Materiais e Mecanica, Instituto de Fisica da Universidade de Sao Paulo, CP 66318, CEP 05315-970 Sao Paulo-SP (Brazil)]. E-mail: hmpetril@macbeth.if.usp.br; Schoen, Claudio Geraldo [Computational Materials Science Lab., Departamento de Engenharia Metalurgica e de Materiais, Escola Politecnica da Universidade de Sao Paulo, Av. Prof. Mello Moraes, 2463, CEP 05508-900 Sao Paulo-SP (Brazil)]. E-mail: schoen@usp.br

    2006-04-15

    metastable phase diagram of the body-centered cubic-based ordering equilibria in the Fe-Al system has been calculated by the cluster expansion method, through the combination of the full potential-linear augmented plane wave and cluster variation methods. The results are discussed with reference to the effect of including the spin polarizations of Fe in the thermodynamic model.

  6. 77 FR 53234 - Certain Communication Equipment, Components Thereof, and Products Containing the Same, Including...

    Science.gov (United States)

    2012-08-31

    ... Farmington Hills, Michigan. 76 FR 76436-37 (Dec. 7, 2011). The complaint alleges a violation of section 337... Investigation named a number of respondents, including Avaya of Basking Ridge, New Jersey; Cisco Consumer Products LLC of Irvine, California, Cisco Systems International B.V. of the Netherlands, Cisco-Linksys...

  7. 15 CFR 9.3 - Appliances and equipment included in program.

    Science.gov (United States)

    2010-01-01

    ..., clothes dryers, kitchen ranges and ovens, water heaters, comfort heating equipment, and television... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Appliances and equipment included in... VOLUNTARY LABELING PROGRAM FOR HOUSEHOLD APPLIANCES AND EQUIPMENT TO EFFECT ENERGY CONSERVATION §...

  8. 78 FR 25304 - Siemens Medical Solutions, USA, Inc., Oncology Care Systems (Radiation Oncology), Including On...

    Science.gov (United States)

    2013-04-30

    ... services. The notice was published in the Federal Register on April 18, 2012 (75 FR 23289). At the request... Employment and Training Administration Siemens Medical Solutions, USA, Inc., Oncology Care Systems (Radiation Oncology), Including On-Site Leased Workers From Source Right Solutions, Concord, California, Now...

  9. A Kantorovich-Stancu Type Generalization of Szasz Operators including Brenke Type Polynomials

    Directory of Open Access Journals (Sweden)

    Rabia Aktaş

    2013-01-01

    Full Text Available We introduce a Kantorovich-Stancu type modification of a generalization of Szasz operators defined by means of the Brenke type polynomials and obtain approximation properties of these operators. Also, we give a Voronovskaya type theorem for Kantorovich-Stancu type operators including Gould-Hopper polynomials.

  10. Superbugs: should antimicrobial resistance be included as a cost in economic evaluation?

    Science.gov (United States)

    Coast, J; Smith, R D; Millar, M R

    1996-01-01

    This paper argues that increasing resistance to antimicrobials is an important social externality that has not been captured at the level of economic appraisal. The paper explicitly considers reasons why the externality of antimicrobial resistance has not generally been included as a cost in economic evaluations comparing management strategies for infectious diseases. Four reasons are considered: first, that the absolute cost of antimicrobial resistance is too small to be worth including; second, that there is an implicit discounting of the costs of antimicrobial resistance on the basis of time preference which makes the cost too small to be worth including; third, that there is an implicit discounting of the costs of antimicrobial resistance on the basis of uncertainty which makes the cost too small to be worth including; and fourth, that the costs are too difficult to measure. Although there does not appear to be methodological justification for excluding the costs of antimicrobial resistance, it seems likely that, because of the practical difficulties associated with measuring these costs, they will continue to be ignored. The paper concludes with a discussion of the applicability of standard policy responses used to deal with externalities in other areas of welfare economics.

  11. Impact of supersonic and subsonic aircraft on ozone: Including heterogeneous chemical reaction mechanisms

    Science.gov (United States)

    Kinnison, Douglas E.; Wuebbles, Donald J.

    1994-01-01

    Preliminary calculations suggest that heterogeneous reactions are important in calculating the impact on ozone from emissions of trace gases from aircraft fleets. In this study, three heterogeneous chemical processes that occur on background sulfuric acid aerosols are included and their effects on O3, NO(x), Cl(x), HCl, N2O5, ClONO2 are calculated.

  12. Towards optimal education including self-regulated learning in technology-enhanced preschools and primary schools

    NARCIS (Netherlands)

    Mooij, Ton; Dijkstra, Elma; Walraven, Amber; Kirschner, Paul A.

    2014-01-01

    At the start of preschool, four-year-old pupils differ in their development, including the capacity to self-regulate their playing and learning. In preschool and primary school, educational processes are generally adapted to the mean age of the pupils in class. The same may apply to ICT-based pupil-

  13. 20 CFR 404.201 - What is included in this subpart?

    Science.gov (United States)

    2010-04-01

    ... DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts General § 404.201 What is included in this subpart? In this subpart we describe how we compute your primary insurance amount (PIA), how and when we... automatically adjust your PIA to reflect changes in the cost of living. (a) What is my primary insurance...

  14. Furan and Alkylated Furans in Heat Processed Food, Including Home Cooked Products

    DEFF Research Database (Denmark)

    Fromberg, Arvid; Mariotti, Maria S.; Pedreschi, Franco;

    2014-01-01

    of carbohydrates. Interestingly, breakfast cereals, dry bread products, and dried fruit products including raisins, plums and bananas contained furan at levels up to 387 mu g/kg. Furan was also found in the dry ingredients of cookies and bread, and in snacks such as crisps and popcorn. The 2-alkylfurans, 2...

  15. Three- and Four-Body Scattering Calculations including the Coulomb Force

    OpenAIRE

    Deltuva, A

    2009-01-01

    The method of screening and renormalization for including the Coulomb interaction in the framework of momentum-space integral equations is applied to the three- and four-body nuclear reactions. The Coulomb effect on the observables and the ability of the present nuclear potential models to describe the experimental data is discussed.

  16. 26 CFR 1.61-2 - Compensation for services, including fees, commissions, and similar items.

    Science.gov (United States)

    2010-04-01

    ... the amount of such difference included in gross income (ii)(A) Cost of life insurance on the life of the employee. Generally, life insurance premiums paid by an employer on the life of his employee where... services on the basis of a percentage of profits, commissions on insurance premiums, tips,...

  17. 29 CFR 780.116 - Commodities included by reference to the Agricultural Marketing Act.

    Science.gov (United States)

    2010-07-01

    ... Marketing Act. 780.116 Section 780.116 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR... Commodities § 780.116 Commodities included by reference to the Agricultural Marketing Act. (a) Section 3(f... defined as agricultural commodities in section 15(g) of the Agricultural Marketing Act, as amended (12...

  18. Adult Education Literacy Instruction. Appendix: Tables of Studies Included in the Review

    Science.gov (United States)

    National Institute for Literacy, 2010

    2010-01-01

    Included here are two appendixes to "Adult Education Literacy Instruction: A Review of the Research." Appendix A, "Adult Studies," contains: (1) Assessment Profiles; (2) Alphabetics; (3) Fluency; (4) Vocabulary; and (5) Comprehension. Appendix B, "Adolescent Studies," contains: (1) Alphabetics; (2) Fluency; (3) Vocabulary; and (4) Comprehension.…

  19. 40 CFR 725.355 - Information to be included in the TME application.

    Science.gov (United States)

    2010-07-01

    ... or the environment as a result of the test marketing. The TME application must be in writing and must... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Information to be included in the TME application. 725.355 Section 725.355 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  20. 75 FR 33634 - Klamath Hydroelectric Settlement Agreement, Including Secretarial Determination on Whether to...

    Science.gov (United States)

    2010-06-14

    ... Secretary of Commerce and other Federal agencies as appropriate, the Secretary shall determine whether, in... years. These developments include: --In 2001, water deliveries to irrigation contractors to Reclamation... spent over $500 million in the Klamath Basin for irrigation, fisheries, National Wildlife Refuges,...

  1. 12 CFR 332.6 - Information to be included in privacy notices.

    Science.gov (United States)

    2010-01-01

    .... 332.6 Section 332.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS... currently disclose, nonpublic personal information. (f) Model privacy form. Pursuant to § 332.2(a) of this part, a model privacy form that meets the notice content requirements of this section is included...

  2. 77 FR 6463 - Revisions to Labeling Requirements for Blood and Blood Components, Including Source Plasma...

    Science.gov (United States)

    2012-02-08

    ... 20993-0002, (301) 796-9148. SUPPLEMENTARY INFORMATION: In the FR Doc. 2011-33554, appearing on page 7 in the Federal Register of Tuesday, January 3, 2012 (77 FR 7), the following correction is made: 1. On... Requirements for Blood and Blood Components, Including Source Plasma; Correction AGENCY: Food and...

  3. Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides

    NARCIS (Netherlands)

    Venema, K.

    2012-01-01

    This review describes the recent advances in technology to study fermentation of lactose and its prebiotic derivatives, including human milk oligosaccharides. Novel molecular tools to identify members of the microbiota that ferment these substrates are highlighted, as well as the use of stable isoto

  4. 21 CFR 1404.220 - Are any procurement contracts included as covered transactions?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Are any procurement contracts included as covered transactions? 1404.220 Section 1404.220 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE... the consent of a(n) Office of National Drug Control Policy official. In that case, the...

  5. KINEMATICS OF THE IONIZED-GAS IN PUPPIS-VELA INCLUDING THE GUM NEBULA

    NARCIS (Netherlands)

    SAHU, MS; SAHU, KC

    1993-01-01

    We present a high resolution spectroscopic study of the ionised gas in Puppis-Vela, which includes the Gum Nebula and the IRAS Vela Shell, in the emission lines of Halpha lambda6563 angstrom, [NII] lambdalambda6548, 6584 angstrom and the [OIII] lambda5007 angstrom. Line profiles were obtained at 18

  6. 76 FR 34271 - Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles Management Unit, Including...

    Science.gov (United States)

    2011-06-13

    ... workers of Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles Management Unit... Employment and Training Administration Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles... Supply Chain Group, including leased workers from QFlex, North America Logistics and UPS...

  7. Equations of motion for a rotor blade, including gravity, pitch action and rotor speed variations

    DEFF Research Database (Denmark)

    Kallesøe, Bjarne Skovmose

    2007-01-01

    This paper extends Hodges-Dowell's partial differential equations of blade motion, by including the effects from gravity, pitch action and varying rotor speed. New equations describing the pitch action and rotor speeds are also derived. The physical interpretation of the individual terms...

  8. 75 FR 9437 - Wacker Chemical Corporation Wacker Polymers Division a Subsidiary of Wacker Chemie AG Including...

    Science.gov (United States)

    2010-03-02

    ... September 2, 2009 (74 FR 45476). At the request of the Company, the Department reviewed the certification... Employment and Training Administration Wacker Chemical Corporation Wacker Polymers Division a Subsidiary of... Chemical Corporation Wacker Polymers Division a Subsidiary of Wacker Chemie AG Including On-Site...

  9. 78 FR 26847 - Including Specific Pavement Types in Federal-aid Highway Traffic Noise Analyses

    Science.gov (United States)

    2013-05-08

    ... Federal Highway Administration Including Specific Pavement Types in Federal-aid Highway Traffic Noise...: The FHWA requests input from stakeholders and interested parties on expanding the specific pavement... data from three pavement types: dense-graded asphaltic concrete (DGAC), open-graded asphaltic...

  10. 75 FR 10317 - DHL Global Forwarding, A Subsidiary of DP DHL, Finance and Accounting Divisions, Including...

    Science.gov (United States)

    2010-03-05

    ... (TA-W-70,857D). The notice was published in the Federal Register on February 16, 2010 (75 FR 7033-7034... Employment and Training Administration DHL Global Forwarding, A Subsidiary of DP DHL, Finance and Accounting... Global Forwarding, A Subsidiary of DP DHL, Finance and Accounting Divisions, Including Workers...

  11. 34 CFR 367.11 - What assurances must a DSA include in its application?

    Science.gov (United States)

    2010-07-01

    ...) and (b), and consistent with 34 CFR 364.28, the DSA will seek to incorporate into and describe in the... section 704 of the Act and subpart C of 34 CFR part 364; and (g) The applicant has been designated by the... 34 Education 2 2010-07-01 2010-07-01 false What assurances must a DSA include in its...

  12. 76 FR 5833 - Polaris Industries, Including On-Site Leased Workers From Westaff, Supply Technologies, Aerotek...

    Science.gov (United States)

    2011-02-02

    ... the Federal Register on September 15, 2010 (75 FR 56143). The notice was amended on December 6, 2010... Register on December 13, 2010 (75 FR 77666). At the request of the State agency, the Department reviewed... Employment and Training Administration Polaris Industries, Including On-Site Leased Workers From...

  13. 76 FR 22729 - Polaris Industries, Including On-Site Leased Workers From Westaff, Supply Technologies, Aerotek...

    Science.gov (United States)

    2011-04-22

    ... vehicles. The notice was published in the Federal ] Register on September 15, 2010 (75 FR 56143). The... December 13, 2010 (75 FR 77666) and February 2, 2011 (76 FR 5833), respectively. At the request of the... Employment and Training Administration Polaris Industries, Including On-Site Leased Workers From...

  14. 33 CFR 150.15 - What must the operations manual include?

    Science.gov (United States)

    2010-07-01

    ... personnel responsible for managing and carrying out the following port activities and functions: (1) Vessel... managing cargo transfers, including ballasting operations if applicable to the port, in accordance with... response teams for specific contingencies. (w) Individual and team training for incident response,...

  15. 75 FR 34169 - Hewlett-Packard Company, Inkjet Consumer Solutions, HP Consumer Hardware Inkjet Lab, Including...

    Science.gov (United States)

    2010-06-16

    ... published in the Federal Register on November 10, 2008 (73 FR 66676). The notice was amended on January 9... in the Federal Register on January 26, 2009 (74 FR 4460). At the request of the State agency, the... Hardware Inkjet Lab, Including Leased Workers From Hightower Technology Capital, Inc., Syncro Design,...

  16. 78 FR 18457 - Definition of Form I-94 To Include Electronic Format

    Science.gov (United States)

    2013-03-27

    ... CBP. Guidance from the Office of Management and Budget (OMB) states regulatory analyses should focus... statistical purposes, including use by the DOC Office of Travel and Tourism Industries to collect monthly... Tourism Organization recommendation for reporting arrivals to all countries. Current Paper Form...

  17. 78 FR 70584 - ATOS IT Solutions & Services, Inc., Billing and Collections Department, Including Workers Whose...

    Science.gov (United States)

    2013-11-26

    ... for the subject firm. The notice was published in the Federal Register on November 6, 2013 (78 FR... Employment and Training Administration ATOS IT Solutions & Services, Inc., Billing and Collections Department, Including Workers Whose Unemployment Insurance (UI) Wages are Reported Through Siemens IT Solutions...

  18. 45 CFR 2522.570 - What information on performance measures must my grant application include?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What information on performance measures must my... APPLICANTS Evaluation Requirements Performance Measures: Requirements and Procedures § 2522.570 What information on performance measures must my grant application include? You must submit all of the following...

  19. 29 CFR 2570.35 - Information to be included in applications for individual exemptions only.

    Science.gov (United States)

    2010-07-01

    ... exemptions only. 2570.35 Section 2570.35 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS... be included in applications for individual exemptions only. (a) Except as provided in paragraph (c... consummated or will be consummated only if the exemption is granted; (14) If the exemption transaction...

  20. Comparison of different methods to include recycling in LCAs of aluminium cans and disposable polystyrene cups

    NARCIS (Netherlands)

    Harst-Wintraecken, van der Eugenie; Potting, José; Kroeze, Carolien

    2016-01-01

    Many methods have been reported and used to include recycling in life cycle assessments (LCAs). This paper evaluates six widely used methods: three substitution methods (i.e. substitution based on equal quality, a correction factor, and alternative material), allocation based on the number of rec

  1. 26 CFR 1.856-0 - Revenue Act of 1978 amendments not included.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Revenue Act of 1978 amendments not included. 1.856-0 Section 1.856-0 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.856-0 Revenue Act of...

  2. 75 FR 54579 - Inclusion of the Hellbender, Including the Eastern Hellbender and the Ozark Hellbender, in...

    Science.gov (United States)

    2010-09-08

    ... you use a telecommunications device for the deaf (TDD), call the Federal Information Relay Service... CITES took effect on May 23, 1977 (42 FR 10465, February 22, 1977), after the first meeting of the..., Guatemala, and Peru includes only logs, sawn wood, and veneer sheets. Therefore, if the criteria...

  3. Optimal design of power system stabilizer for power systems including doubly fed induction generator wind turbines

    International Nuclear Information System (INIS)

    This paper presents an evolutionary algorithm-based approach for optimal design of power system stabilizer (PSS) for multi-machine power systems that include doubly fed induction generator wind turbines. The proposed evolutionary algorithm is an improved particle swarm optimization named chaotic particle swarm optimization with passive congregation (CPSO-PC) applied for finding the optimal settings of PSS parameters. Two different eigenvalue-based objectives are combined as the objective function for the optimization problem of tuning PSS parameters. The first objective function comprises the damping factor of lightly damped electro-mechanical modes and the second one includes the damping ratio of these modes. The effectiveness of the proposed method to design PSS for the power systems including DFIG (Doubly Fed Induction Generator) is extensively demonstrated through eigenvalue analysis and time-domain simulations and also by comparing its simulation results with the results of other heuristic optimization approaches. - Highlights: • A new optimization model for design of PSS in power systems including DFIG is proposed. • A detailed and realistic modeling of DFIG is presented. • A new evolutionary algorithm is suggested for solving the optimization problem of designing PSS

  4. 78 FR 16865 - Certain Electronic Devices, Including Wireless Communication Devices, Portable Music and Data...

    Science.gov (United States)

    2013-03-19

    ... America, LLC of Richardson, Texas (collectively, ``Samsung''). 76 FR 45860 (Aug. 1, 2011). The complaint... Commission, and on the issues of remedy, the public interest, and bonding. 77 FR 70464. The Commission... COMMISSION Certain Electronic Devices, Including Wireless Communication Devices, Portable Music and...

  5. 77 FR 70464 - Certain Electronic Devices, Including Wireless Communication Devices, Portable Music and Data...

    Science.gov (United States)

    2012-11-26

    ... Telecommunications America, LLC of Richardson, Texas (collectively, ``Samsung''). 76 FR 45860 (Aug. 1, 2011). The... Presidential Memorandum of July 21, 2005, 70 FR 43251 (July 26, 2005). During this period, the subject articles... COMMISSION Certain Electronic Devices, Including Wireless Communication Devices, Portable Music and...

  6. Including Parent Training in the Early Childhood Special Education Curriculum for Children with Autism Spectrum Disorders

    Science.gov (United States)

    Ingersoll, Brooke; Dvortcsak, Anna

    2006-01-01

    Parent training has been shown to be a very effective method for promoting generalization and maintenance of skills in children with autism. However, despite its well-established benefits, few public school programs include parent training as part of the early childhood special education (ECSE) curriculum. Barriers to the provision of parent…

  7. 21 CFR 200.10 - Contract facilities (including consulting laboratories) utilized as extramural facilities by...

    Science.gov (United States)

    2010-04-01

    ... laboratories) utilized as extramural facilities by pharmaceutical manufacturers. 200.10 Section 200.10 Food and... GENERAL General Provisions § 200.10 Contract facilities (including consulting laboratories) utilized as...) The Food and Drug Administration is aware that many manufacturers of pharmaceutical products...

  8. 41 CFR 102-37.75 - What should be included in a shortage report?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What should be included in a shortage report? 102-37.75 Section 102-37.75 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY...

  9. 30 CFR 250.527 - What must I include in my casing pressure request?

    Science.gov (United States)

    2010-07-01

    ... following information must be included in the casing pressure request: (a) API number; (b) Lease number; (c... and the calculated daily production rate during last well test (oil, gas, basic sediment, and water... (dry tree, hybrid, or subsea); (n) Date of diagnostic test; (o) Well schematic; (p) Water depth;...

  10. Sharing the Focus: Engaging with Support Workers to Include People with Communication Needs in Research

    Science.gov (United States)

    Lutz, Deborah; Fisher, Karen R.; Robinson, Sally

    2016-01-01

    Inclusive research is an increasing expectation to value and include people's voice in research and evaluations intended to benefit them. The active participation of people with communication support needs can be difficult due to the practical constraints of evaluations. One technique is to engage with workers who are familiar with the person, but…

  11. 75 FR 34172 - Lordstown Seating Systems, a Subsidiary of Magna Seating, Including Workers Whose Unemployment...

    Science.gov (United States)

    2010-06-16

    ... notice was published in the Federal Register on May 5, 2010 (75 FR 24751). At the request of the state... Employment and Training Administration Lordstown Seating Systems, a Subsidiary of Magna Seating, Including Workers Whose Unemployment Insurance (UI) Wages Are Reported Through Intier Automotive Seatings of...

  12. Including dietary fiber and resistant starch to increase satiety and reduce aggression in gestating sows

    Science.gov (United States)

    The swine industry is under a great deal of pressure to return sows to group housing. However, aggression during mixing of pregnant sows impacts sow welfare and productivity. The aim of this study was to increase satiety and reduce aggression by including dietary fiber and fermentable carbohydrate. ...

  13. 75 FR 41895 - Whirlpool Corporation, Evansville Division, Including On-Site Leased Workers From Andrews...

    Science.gov (United States)

    2010-07-19

    ... Workers From Andrews International, Inc., M.H. Equipment, and Kenco Logistics Services, LLC, Evansville..., Evansville Division, including on-site leased workers from Andrews International, Inc., Kenco Logistics... notice was published in the Federal Register on March 5, 2010 (75 FR 10321). The notice was amended...

  14. Tornadoes: Nature's Most Violent Storms. A Preparedness Guide Including Safety Information for Schools.

    Science.gov (United States)

    American National Red Cross, Washington, DC.

    This preparedness guide explains and describes tornadoes, and includes safety information for schools. A tornado is defined as a violently rotating column of air extending from a thunderstorm to the ground. The guide explains the cause of tornadoes, provides diagrams of how they form, describes variations of tornadoes, and classifies tornadoes by…

  15. 76 FR 43349 - General Motors Corporation, Renaissance Center, including On-Site Leased Workers From Accretive...

    Science.gov (United States)

    2011-07-20

    ... the Federal Register on May 20, 2010 (75 FR 28299). The notice was amended on August 31, 2010 to... Register on September 13, 2010 (75 FR 55613-55614). At the request of the State agency, the Department... Employment and Training Administration General Motors Corporation, Renaissance Center, including...

  16. 78 FR 8587 - Thomson Reuters, Finance Operations & Technology Division, Including On-Site Leased Workers From...

    Science.gov (United States)

    2013-02-06

    ... was published in the Federal Register on August 16, 2012 (77 FR 49459). At the request of the State... Employment and Training Administration Thomson Reuters, Finance Operations & Technology Division, Including... Worker Adjustment Assistance on August 2, 2012, applicable to workers of Thomson Reuters,...

  17. 21 CFR 822.9 - What must I include in my submission?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false What must I include in my submission? 822.9 Section 822.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.9 What must I...

  18. 21 CFR 822.10 - What must I include in my surveillance plan?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false What must I include in my surveillance plan? 822.10 Section 822.10 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.10...

  19. 16 CFR 1203.34 - Product certification and labeling by manufacturers (including importers).

    Science.gov (United States)

    2010-01-01

    ... manufacturers (including importers). 1203.34 Section 1203.34 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Certification § 1203... “Complies with U.S. CPSC Safety Standard for Bicycle Helmets for Persons Age 5 and Older” or “Complies...

  20. 26 CFR 1.951-1 - Amounts included in gross income of United States shareholders.

    Science.gov (United States)

    2010-04-01

    ... shareholders. Therefore, the redemption rights are not restrictions or other limitations within the meaning of... States shareholders. 1.951-1 Section 1.951-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... included in gross income of United States shareholders. (a) In general. If a foreign corporation is...

  1. 5 CFR 841.605 - Interest included in the unexpended balance.

    Science.gov (United States)

    2010-01-01

    ... balance. 841.605 Section 841.605 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... Interest § 841.605 Interest included in the unexpended balance. (a) Interest on each Individual Retirement Record is computed separately. (b) For determining the amount of interest in the unexpended balance...

  2. 45 CFR 1308.13 - Eligibility criteria: Visual impairment including blindness.

    Science.gov (United States)

    2010-10-01

    ... blindness. 1308.13 Section 1308.13 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE... impairment including blindness. (a) A child is classified as visually impaired when visual impairment, with.... A child is visually impaired if: (1) The vision loss meets the definition of legal blindness in...

  3. Including Indigenous Knowledges and Pedagogies in Science-Based Environmental Education Programs

    Science.gov (United States)

    Sutherland, Dawn; Swayze, Natalie

    2012-01-01

    In exploring ways to respectfully include Indigenous Knowledges and pedagogies within environmental education programs, the challenge is to ensure strategies used will meaningfully support learning while reflecting local cultural traditions, languages, beliefs, and perspectives. In this paper, key components for science-based environmental…

  4. 78 FR 13895 - Certain Consumer Electronics, Including Mobile Phones and Tablets; Commission Determination Not...

    Science.gov (United States)

    2013-03-01

    ...,237,025; 7,054,904; 7,185,054; and 7,206,809. 77 FR 24514 (Apr. 24, 2012). The Commission named ASUSTe... COMMISSION Certain Consumer Electronics, Including Mobile Phones and Tablets; Commission Determination Not To... importation, or sale within the United States after importation of certain consumer electronics,...

  5. 20 CFR 666.100 - What performance indicators must be included in a State's plan?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What performance indicators must be included in a State's plan? 666.100 Section 666.100 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION..., respectively and the two customer satisfaction indicators. (1) For the Adult program, these indicators are:...

  6. 76 FR 24914 - Digital River Education Services, Inc., a Division of Digital River, Inc., Including Workers...

    Science.gov (United States)

    2011-05-03

    ... Employment and Training Administration Digital River Education Services, Inc., a Division of Digital River... Marketing (JEM), Including On-Site Lease Workers From Serenity Staffing, Accountemps, Silicon Valley, and... Assistance on January 28, 2011, applicable to workers of Digital River Education Services, Inc., a...

  7. 20 CFR 410.410 - Total disability due to pneumoconiosis, including statutory presumption.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Total disability due to pneumoconiosis... Death Due to Pneumoconiosis § 410.410 Total disability due to pneumoconiosis, including statutory... pneumoconiosis arising out of employment in one or more of the Nation's coal mines,” and to the...

  8. 20 CFR 410.416 - Determining origin of pneumoconiosis, including statutory presumption.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determining origin of pneumoconiosis... Death Due to Pneumoconiosis § 410.416 Determining origin of pneumoconiosis, including statutory... suffered from pneumoconiosis, it will be presumed, in the absence of persuasive evidence to the...

  9. 26 CFR 31.3121(q)-1 - Tips included for employee taxes.

    Science.gov (United States)

    2010-04-01

    ... remuneration paid to the employee. Thus, where employees practice tip splitting (for example, where waiters pay... of $100 and on November 9, 1966, A furnishes X restaurant a report of tips actually received by him... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Tips included for employee taxes....

  10. 10 CFR 1021.330 - Programmatic (including site-wide) NEPA documents.

    Science.gov (United States)

    2010-01-01

    ... documents. (a) When required to support a DOE programmatic decision (40 CFR 1508.18(b)(3)), DOE shall prepare a programmatic EIS or EA (40 CFR 1502.4). DOE may also prepare a programmatic EIS or EA at any... 10 Energy 4 2010-01-01 2010-01-01 false Programmatic (including site-wide) NEPA documents....

  11. Modification of a fire drought index for tropical wetland ecosystems by including water table depth

    NARCIS (Netherlands)

    Taufik, Muh; Setiawan, B.I.; Lanen, van H.A.J.

    2015-01-01

    In this paper, we discuss how an existing empirical drought index, i.e. the Keetch-Byram Drought Index (KBDI) that is commonly used for assessing forest fire danger, has been adjusted and modified for improved use in tropical wetland ecosystems. The improvement included: (i) adjustment of the dro

  12. 76 FR 76434 - Certain Integrated Circuits, Chipsets, and Products Containing Same Including Televisions...

    Science.gov (United States)

    2011-12-07

    ...Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled In Re Certain Integrated Circuits, Chipsets, And Products Containing Same including Televisions, DN 2860; the Commission is soliciting comments on any public interest issues raised by the...

  13. Membrane for distillation including nanostructures, methods of making membranes, and methods of desalination and separation

    KAUST Repository

    Lai, Zhiping

    2016-01-21

    In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure provide membranes, methods of making the membrane, systems including the membrane, methods of separation, methods of desalination, and the like.

  14. 77 FR 46516 - Notice of Availability of the Final Environmental Impact Statement, Including a Programmatic...

    Science.gov (United States)

    2012-08-03

    ... groundwater rights (if permitted by the NSE) with the remaining capacity reserved for future use by Lincoln... 4500034975; TAS: 14X5017] Notice of Availability of the Final Environmental Impact Statement, Including a... the National Environmental Policy Act (NEPA) of 1969, as amended, and the National...

  15. Impact of supersonic and subsonic aircraft on ozone: Including heterogeneous chemical reaction mechanisms

    International Nuclear Information System (INIS)

    Preliminary calculations suggest that heterogeneous reactions are important in calculating the impact on ozone from emissions of trace gases from aircraft fleets. In this study, three heterogeneous chemical processes that occur on background sulfuric acid aerosols are included and their effects on O3, NOx, Clx, HCl, N2O5, ClONO2 are calculated

  16. Specifications and design criteria for innovative corrosion monitoring and (downhole) sensor systems, including sensitivity analysis

    NARCIS (Netherlands)

    Zhang, X.; Kermen. E.

    2013-01-01

    This report focuses on the corrosion monitoring and corrosion sensor systems, for use in CO2 storage wells, including a sensitivity analysis. The feasibility for using new sensors to measure well integrity based on electrochemical principles is investigated. The use of corrosion sensors in CO2 stora

  17. Pilot's Guide to an Airline Career, Including Sample Pre-Employment Tests.

    Science.gov (United States)

    Traylor, W.L.

    Occupational information for persons considering a career as an airline pilot includes a detailed description of the pilot's duties and material concerning preparation for occupational entry and determining the relative merits of available jobs. The book consists of four parts: Part I, The Job, provides an overview of a pilot's duties in his daily…

  18. 78 FR 41259 - Importation of Fresh Citrus Fruit From Uruguay, Including Citrus

    Science.gov (United States)

    2013-07-10

    ... (78 FR 8435-8441, Docket No. APHIS-2011-0060) a proposal \\1\\ to amend the regulations concerning the... Inspection Service 7 CFR Part 319 RIN 0579-AD59 Importation of Fresh Citrus Fruit From Uruguay, Including... the Citrus-related genus Fortunella, from Uruguay into the continental United States. As a...

  19. 78 FR 8435 - Importation of Fresh Citrus Fruit From Uruguay, Including Citrus Hybrids and Fortunella

    Science.gov (United States)

    2013-02-06

    ... From Uruguay, Including Citrus Hybrids and Fortunella spp., Into the Continental United States AGENCY... citrus fruit, as well as Citrus hybrids and the Citrus-related genus Fortunella, from Uruguay into the... certificate issued by the national plant protection organization of Uruguay with an additional...

  20. 40 CFR 35.4140 - What must be included in my group's work plan?

    Science.gov (United States)

    2010-07-01

    ... work plan? 35.4140 Section 35.4140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... Tag § 35.4140 What must be included in my group's work plan? (a) Your scope of work must clearly... community. (b) Your scope of work must also clearly explain your project's milestones and the schedule...

  1. 12 CFR 516.20 - What information must I include in my draft business plan?

    Science.gov (United States)

    2010-01-01

    ... business plan? 516.20 Section 516.20 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... What information must I include in my draft business plan? If you must submit a draft business plan... described in the savings association's draft business plan; and (d) Demonstrate how applicable...

  2. 76 FR 45860 - In the Matter of Certain Electronic Devices, Including Wireless Communication Devices, Portable...

    Science.gov (United States)

    2011-08-01

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of Certain Electronic Devices, Including Wireless Communication Devices, Portable...; Institution of Investigation Pursuant to 19 U.S.C. 1337 AGENCY: U.S. International Trade Commission....

  3. 76 FR 24051 - In the Matter of Certain Electronic Devices, Including Mobile Phones, Mobile Tablets, Portable...

    Science.gov (United States)

    2011-04-29

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of Certain Electronic Devices, Including Mobile Phones, Mobile Tablets, Portable.... International Trade Commission. ACTION: Notice. SUMMARY: Notice is hereby given that a complaint was filed...

  4. Day-ahead resource scheduling including demand response for electric vehicles

    DEFF Research Database (Denmark)

    Soares, Joao; Morais, Hugo; Sousa, Tiago;

    2014-01-01

    . Mixed integer non-linear programming is also used for comparison purposes. Full ac power flow calculation is included to allow taking into account the network constraints. A case study with a 33-bus distribution network and 2000 V2G resources is used to illustrate the performance of the proposed method....

  5. 21 CFR 111.210 - What must the master manufacturing record include?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What must the master manufacturing record include... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING...: Requirements for the Master Manufacturing Record § 111.210 What must the master manufacturing record...

  6. Global simulations of Minkowski space-time including space-like infinity

    CERN Document Server

    Doulis, Georgios

    2016-01-01

    In this work, we study linearised gravitational fields on the entire Minkowski space-time including space-like infinity. The generalised conformal field equations linearised about a Minkowski background are utilised for this purpose. In principle, this conformal representation of Einstein's equations can be used to carry out global simulations of Minkowski space-time. We investigate thoroughly this possibility.

  7. 78 FR 39773 - Monta Vista Software, LLC, a Subsidiary of Cavium, Inc., Including Workers Whose Unemployment...

    Science.gov (United States)

    2013-07-02

    ... Workers Whose Unemployment Insurance (UI) Wages are Reported Through Trinet HR Corporation, Arlington..., LLC, A Subsidiary of Cavium, Inc., Including Workers Whose Unemployment Insurance (UI) Wages, are... Cavium, Inc. had their wages reported through a separate unemployment insurance (UI) tax account...

  8. 77 FR 33490 - Long Elevator & Machine Company, Inc., Including Workers Whose Unemployment Insurance (UI) Wages...

    Science.gov (United States)

    2012-06-06

    ... Unemployment Insurance (UI) Wages Were Reported Through Kone, Inc., Riverton, IL; Notice of Affirmative...., including workers whose unemployment insurance (UI) wages were reported through KONE Inc., Riverton... was published in the Federal Register on April 10, 2012 (77 FR 21590). The subject firm is engaged...

  9. 75 FR 47460 - TRICARE: Changes Included in the National Defense Authorization Act for Fiscal Year 2007...

    Science.gov (United States)

    2010-08-06

    ... of the Secretary 32 CFR Part 199 TRICARE: Changes Included in the National Defense Authorization Act... section 703 of the National Defense Authorization Act (NDAA) for Fiscal Year 2007 (FY07), Public Law 109... cancer screenings to be brought in line with the processes for updating other cancer...

  10. 40 CFR 725.455 - Information to be included in the Tier II exemption request.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Information to be included in the Tier II exemption request. 725.455 Section 725.455 Protection of Environment ENVIRONMENTAL PROTECTION... identification. (2) Type of genetic modification and the function of the introduced genetic material. (3) Site...

  11. Fast motion-including dose error reconstruction for VMAT with and without MLC tracking

    DEFF Research Database (Denmark)

    Ravkilde, Thomas; Keall, Paul J.; Grau, Cai;

    2014-01-01

    validate a simple model for fast motion-including dose error reconstruction applicable to intrafractional QA of MLC tracking treatments of moving targets. MLC tracking experiments were performed on a standard linear accelerator with prototype MLC tracking software guided by an electromagnetic transponder...

  12. 27 CFR 53.91 - Charges to be included in sale price.

    Science.gov (United States)

    2010-04-01

    ... or display of the article, for sales promotion programs, or otherwise. With respect to the rules... sale price. 53.91 Section 53.91 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... AMMUNITION Special Provisions Applicable to Manufacturers Taxes § 53.91 Charges to be included in sale...

  13. 32 CFR 37.710 - What standards do I include for purchasing systems of nonprofit organizations?

    Science.gov (United States)

    2010-07-01

    ... governmental organization. (2) 32 CFR 32.40 through 32.49 if the participant is a nonprofit organization other... systems of nonprofit organizations? 37.710 Section 37.710 National Defense Department of Defense OFFICE OF... standards do I include for purchasing systems of nonprofit organizations? (a) So as not to force...

  14. Modification of TOUGH2 to Include the Dusty Gas Model for Gas Diffusion; TOPICAL

    International Nuclear Information System (INIS)

    The GEO-SEQ Project is investigating methods for geological sequestration of CO(sub 2). This project, which is directed by LBNL and includes a number of other industrial, university, and national laboratory partners, is evaluating computer simulation methods including TOUGH2 for this problem. The TOUGH2 code, which is a widely used code for flow and transport in porous and fractured media, includes simplified methods for gas diffusion based on a direct application of Fick's law. As shown by Webb (1998) and others, the Dusty Gas Model (DGM) is better than Fick's Law for modeling gas-phase diffusion in porous media. In order to improve gas-phase diffusion modeling for the GEO-SEQ Project, the EOS7R module in the TOUGH2 code has been modified to include the Dusty Gas Model as documented in this report. In addition, the liquid diffusion model has been changed from a mass-based formulation to a mole-based model. Modifications for separate and coupled diffusion in the gas and liquid phases have also been completed. The results from the DGM are compared to the Fick's law behavior for TCE and PCE diffusion across a capillary fringe. The differences are small due to the relatively high permeability (k= 10(sup -11) m(sup 2)) of the problem and the small mole fraction of the gases. Additional comparisons for lower permeabilities and higher mole fractions may be useful

  15. 41 CFR 302-3.504 - What information should we include in a service agreement?

    Science.gov (United States)

    2010-07-01

    ... ALLOWANCE BY SPECIFIC TYPE Agency Responsibilities Service Agreements § 302-3.504 What information should we... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What information should we include in a service agreement? 302-3.504 Section 302-3.504 Public Contracts and...

  16. 34 CFR 366.43 - What must be included in the Director's final written decision?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What must be included in the Director's final written decision? 366.43 Section 366.43 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION CENTERS...

  17. 77 FR 37067 - Certain Liquid Crystal Display Devices, Including Monitors, Televisions, Modules, and Components...

    Science.gov (United States)

    2012-06-20

    ... France and Thomson Licensing LLC of Princeton, New Jersey (collectively ``Thomson''). 75 FR 63856 (Oct... Thomson. 75 FR 74080 (Nov. 30, 2010). The complaint alleged violations of section 337 of the Tariff Act of... COMMISSION Certain Liquid Crystal Display Devices, Including Monitors, Televisions, Modules, and...

  18. 42 CFR 423.888 - Payment methods, including provision of necessary information.

    Science.gov (United States)

    2010-10-01

    ... historical data and generally accepted actuarial principles) of the difference between such gross costs and... necessary information. (a) Basis. The provisions of § 423.301 through § 423.343, including requirements to... annual basis, as elected by the plansponsor under guidance specified by CMS, unless CMS determines...

  19. Including Antenna Models in Microwave Imaging for Breast-Cancer Screening

    DEFF Research Database (Denmark)

    Rubæk, Tonny; Meincke, Peter

    2006-01-01

    Microwave imaging is emerging as a tool for screening for breast cancer, but the lack of methods for including the characteristics of the antennas of the imaging systems in the imaging algorithms limits their performance. In this paper, a method for incorporating the full antenna characteristics,...

  20. Thermoelectric material including conformal oxide layers and method of making the same using atomic layer deposition

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jung Young; Ahn, Dongjoon; Salvador, James R.; Meisner, Gregory P.

    2016-06-07

    A thermoelectric material includes a substrate particle and a plurality of conformal oxide layers formed on the substrate particle. The plurality of conformal oxide layers has a total oxide layer thickness ranging from about 2 nm to about 20 nm. The thermoelectric material excludes oxide nanoparticles. A method of making the thermoelectric material is also disclosed herein.