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Sample records for cellpro ceprate sc

  1. Pulsed SC Proton Linac

    OpenAIRE

    Ouchi, N.; Chishiro, E.; Tsukishima, C.; Mukugi, K.

    2000-01-01

    The superconducting (SC) proton linac is proposed in the JAERI/KEK Joint Project for a high-intensity proton accelerator in the energy region from 400 to 600 MeV. Highly stable fields in the SC cavities are required under the dynamic Lorentz force detuning. A new model describing the dynamic Lorentz detuning has been developed and the validity has been confirmed experimentally. The model has been applied successfully to the rf control simulation of the SC proton linac.

  2. SC tuning fork

    CERN Multimedia

    The tuning fork used to modulate the radiofrequency system of the synchro cyclotron (SC) from 1957 to 1973. This piece is an unused spare part. The SC was the 1st accelerator built at CERN. It operated from August 1957 until it was closed down at the end of 1990. In the SC the magnetic field did not change with time, and the particles were accelerated in successive pulses by a radiofrequency voltage of some 20kV which varied in frequency as they spiraled outwards towards the extraction radius. The frequency varied from 30MHz to about 17Mz in each pulse. The tuning fork vibrated at 55MHz in vacuum in an enclosure which formed a variable capacitor in the tuning circuit of the RF system, allowing the RF to vary over the appropriate range to accelerate protons from the centre of the macine up to 600Mev at extraction radius. In operation the tips of the tuning fork blade had an amplitude of movement of over 1 cm. The SC accelerator underwent extensive improvements from 1973 to 1975, including the installation of a...

  3. Formation cross sections of 43Sc, 44Sc and 46Sc isotopes in the 45Sc + 3He reaction

    International Nuclear Information System (INIS)

    In the experiments performed on the 3He-ion beam irradiation scandium targets at the U-120M cyclotron of the Institute of Nuclear Physics of the Czech Academy of Sciences, Rez, 45Sc(3He, αn)43Sc, 45Sc(3He,α)44Sc and 45Sc(3He, 2p)46Sc reactions were investigated in the 3He energy range from 5 to 24 MeV. To determine the yield of resulting Sc isotope, activation technique was used. A measurement of γ-activity induced in the target was carried out using HPGe-detector of high resolution. Despite the low binding energy of 3He and positive values of Q-reactions leading to the formation of 44Sc and 46Sc isotopes, the behavior of excitation functions for the formation of these isotopes is different from the behavior of excitation functions for deuterons. Cross sections for 44Sc reach their maximum at the Coulomb barrier of the reaction. This is due to the fact that the stable core of 4He forms in the reaction in addition to 44Sc

  4. Structural and electronic properties of ScSb, ScAs, ScP and ScN

    Energy Technology Data Exchange (ETDEWEB)

    Tebboune, AbdelGhani; Belbachir, A.H. [Departement de physique, Universite des Sciences et Technologie Mohamed Boudiaf d' Oran, 31000 Oran (Algeria); Rached, Djamel [Applied Materials Laboratory, Centre de Recherches (ex-CFTE), Universite de Sidi Bel Abbes, 22000 Sidi Bel Abbes (Algeria); Benzair, AbdelNour [Departement de Physique, Universite de Sidi Bel Abbes, 22000 Sidi Bel Abbes (Algeria); Sekkal, Nadir [Departement de Physique-Chimie, Ecole Normale Superieure de l' Enseignement Technique, BP 1523, El M' Naouer, 31000 Oran (Algeria); Computational Materials Science Laboratory, Departement de Physique, Institut de Sciences Exactes, Universite de Sidi Bel Abbes, 22000 Sidi Bel Abbes (Algeria); Physia-Laboratory, BP 47 (RP), 22000 Sidi Bel Abbes (Algeria)

    2006-10-15

    The structural and electronic properties of ScSb, ScAs, ScP and ScN III-V materials are investigated within a version of the first-principles full potential linear Muffin-Tin orbitals method (FPLMTO) that enables an accurate treatment of the interstitial regions. At high pressure, the transition from rocksalt (B1) to CsCl (B2) structure is found to be possible. The zinc blende phase is also investigated and is found to give a semiconductor behavior with a wide bandgap to all our materials. The latter is direct at X for ScAs, ScSb, ScP. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  5. Structural and electronic properties of ScSb, ScAs, ScP and ScN

    International Nuclear Information System (INIS)

    The structural and electronic properties of ScSb, ScAs, ScP and ScN III-V materials are investigated within a version of the first-principles full potential linear Muffin-Tin orbitals method (FPLMTO) that enables an accurate treatment of the interstitial regions. At high pressure, the transition from rocksalt (B1) to CsCl (B2) structure is found to be possible. The zinc blende phase is also investigated and is found to give a semiconductor behavior with a wide bandgap to all our materials. The latter is direct at X for ScAs, ScSb, ScP. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  6. Absolute transition probabilities in Sc I and Sc II

    International Nuclear Information System (INIS)

    Absolute atomic transition probabilities for emission lines from 70 levels in Sc I and Sc II are reported. The transition probabilities are from emission branching ratios measured using the 1.0-m Fourier-transform spectrometer at the National Solar Observatory. Radiative lifetimes, measured using time-resolved laser-induced fluorescence, provide the normalization for converting the branching ratios to absolute transition probabilities. These results are compared with other experimental and theoretical transition probabilities

  7. Extinction in SC galaxies

    Science.gov (United States)

    Giovanelli, Riccardo; Haynes, Martha P.; Salzer, John J.; Wegner, Gary; da Costa, Luiz N.; Freudling, Wolfram

    1994-06-01

    We analyze the photometric properties of a sample of Sbc-Sc galaxies with known redshifts, single-dish H I profiles, and Charge Coupled Device (CCD) I band images. We derive laws that relate the measured isophotal radius at muI = 23.5, magnitude, scale length, and H I flux to the face-on aspect. We find spiral galaxies to be substantially less transparent than suggested in most previous determinations, but not as opaque as claimed by Valentijn (1990). Regions in the disk farther than two or three scale lengths from the center are close to completely transparent. In addition to statistically derived relations for the inclination dependence of photometric parameters, we present the results of a modeling exercise that utilizes the 'triplex' model of Disney et al. (1989) to obtain upper limits of the disk opacity. Within the framework of that model, and with qualitative consideration of the effects of scattering on extinction, we estimate late spiral disks at I band to have central optical depths tauI(0) less than 5 and dust absorbing layers with scale heights on the order of half that of the stellar component or less. We discuss our results in light of previous determinations of internal extinction relations and point out the substantial impact of internal extinction on the scatter of the Tully-Fisher relation. We also find that the visual diameters by which large catalogs are constructed (UGC, ESO-Uppsala) are nearly proportional to face-on isophotal diameters.

  8. Monitor of SC beam profiles

    CERN Multimedia

    1977-01-01

    A high-resolution secondary emission grid for the measurement of SC beam profiles. Modern techniques of metal-ceramic bonding, developed for micro-electronics, have been used in its construction. (See Annual Report 1977 p. 105 Fig. 12.)

  9. Rotary condenser for SC2

    CERN Multimedia

    1975-01-01

    During 1975 the SC2 performance was improved among other things by redesigning some of the elements of the ROTCO (Annual Report 1975, p. 55). The photo shows an interior wiew of the housing of the rotary condenser and of the sixteen sets of shaped stator blades.

  10. Radiative lifetimes of even- and odd-parity levels in Sc I and Sc II

    International Nuclear Information System (INIS)

    Time-resolved laser-induced fluorescence on atomic and ionic beams is used to measure radiative lifetimes for 77 odd- and even-parity levels of Sc I and Sc II. Time-of-flight selection of slow Sc atoms is demonstrated to minimize error in long lifetimes, an error that arises because escape from the observing region before radiating. High-lying even-parity levels in Sc I and Sc II are excited by using two-step laser excitation

  11. Xemilofiban: SC 54684A, xemlofiban.

    Science.gov (United States)

    2003-01-01

    Xemilofiban [SC 54684, SC 54684A (HCl), xemlofiban], a glycoprotein IIb/IIIa antagonist, is an orally available prodrug of a non-peptide mimetic of the tetrapeptide RGDF. It is converted to the active metabolite, SC 54701 (the free base form of SC 54701A). Development was initiated by Searle (Monsanto). Searle became part of Pharmacia Corporation, which was acquired by, and merged into, Pfizer in April 2003. Searle had co-development and co-marketing agreements with Sankyo in Japan; these have been discontinued. In January 2003, Pharmacia donated the intellectual property for xemilofiban to Western Michigan University. In February 2003, Western Michigan University granted an exclusive worldwide licence of xemilofiban to VDDI Pharmaceuticals (formerly Virtual Drug Development Inc.). Xemilofiban was in a phase III clinical trial, the Evaluation of Xemilofiban in Controlling Thrombotic Events (EXCITE) trial, with Searle (Monsanto) in the US and Europe for the treatment of thrombosis in patients with unstable angina pectoris and acute myocardial infarction undergoing angioplasty. However, as xemilofiban demonstrated no significant clinical benefit, Searle discontinued its development. In Japan, Sankyo discontinued the development of xemilofiban for thrombosis at phase II following Searle's decision to drop the project. VDDI Pharmaceuticals plans to develop xemilofiban in cardiovascular disorders following on from the phase III studies completed by Pharmacia; a restructured dosing schedule and narrowed patient selection will be used. VDDI has research facilities worldwide and will utilise facilities in Ireland for the European clinical development programme; research facilities in the Southwest Michigan Innovation Center are planned while the head office of VDDI is based in Tennessee. Xemilofiban is in phase III development for the treatment of cardiovascular disease in conjunction with percutaneous coronary intervention. PMID:14584975

  12. 46 CFR 7.70 - Folly Island, SC to Hilton Head Island, SC.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Folly Island, SC to Hilton Head Island, SC. 7.70 Section... BOUNDARY LINES Atlantic Coast § 7.70 Folly Island, SC to Hilton Head Island, SC. (a) A line drawn from the southernmost extremity of Folly Island to latitude 32°35′ N. longitude 79°58.2′ W. (Stono Inlet Lighted...

  13. The xerocytosis of Hb SC disease.

    Science.gov (United States)

    Ballas, S K; Larner, J; Smith, E D; Surrey, S; Schwartz, E; Rappaport, E F

    1987-01-01

    Patients with Hb SC disease were found to have microcytic and hyperchromic red cell indices despite mild reticulocytosis. Iron deficiency anemia was ruled out by the finding of normal serum ferritin levels. In order to determine whether the microcytosis was due to coexistent alpha-thalassemia, restriction endonuclease mapping was performed on genomic DNA extracted from peripheral blood leukocytes. Patients with Hb SC disease had microcytic indices despite the presence of a full complement of four alpha-genes (alpha alpha/alpha alpha), suggesting that the microcytosis may be due to cellular dehydration (or xerocytosis), since the mean corpuscular hemoglobin concentration in Hb SC disease patients was significantly higher than in controls. This possibility was investigated further by the determination of RBC cation content. RBC Na levels were similar in SC and normal red cells. Hb SC RBCs, however, had significantly reduced K levels. These findings show that RBC cation content, and thus cell water, is decreased in Hb SC disease. The decreased RBC K level in the presence of normal cellular Na concentration suggests selective K loss that is not due to inhibition of the Na K pump. Ouabain-insensitive K+ efflux was increased to four times normal in SC cells. Cell dehydration was confirmed by the demonstration of increased high-density RBCs on discontinuous Stractan density gradients and by osmotic gradient ektacytometry. Cellular dehydration and its sequelae were worse in CC erythrocytes and milder in AC cells than in Hb SC red cells. Taken together, these data indicate that in Hb SC disease the RBCs are severely dehydrated and typically microcytic and hyperchromic. Hb SC RBCs seem to be dehydrated due to selective K loss. These findings suggest a functional interrelationship between Hb SC, the red cell membrane, and cation regulation. PMID:2947642

  14. rotor of the SC rotating condenser

    CERN Multimedia

    1974-01-01

    The rotor of the rotating condenser was installed instead of the tuning fork as the modulating element of the radiofrequency system, when the SC accelerator underwent extensive improvements between 1973 to 1975 (see object AC-025). The SC was the first accelerator built at CERN. It operated from August 1957 until it was closed down at the end of 1990.

  15. Academic Training - Pulsed SC Magnets

    CERN Multimedia

    Françoise Benz

    2006-01-01

    2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 2, 3, June 29, 30, 31 May, 1, 2 June 11:00-12:00 - Auditorium, bldg 500 Pulsed SC Magnets by M. Wilson Lecture 1. Introduction to Superconducting Materials Type 1,2 and high temperature superconductors; their critical temperature, field & current density. Persistent screening currents and the critical state model. Lecture 2. Magnetization and AC Loss How screening currents cause irreversible magnetization and hysteresis loops. Field errors caused by screening currents. Flux jumping. The general formulation of ac loss in terms of magnetization. AC losses caused by screening currents. Lecture 3. Twisted Wires and Cables Filamentary composite wires and the losses caused by coupling currents between filaments, the need for twisting. Why we need cables and how the coupling currents in cables contribute more ac loss. Field errors caused by coupling currents. Lecture 4. AC Losses in Magnets, Cooling and Measurement Summary of all loss mech...

  16. Cs3ScCl6

    Directory of Open Access Journals (Sweden)

    Matthew D. Ward

    2014-06-01

    Full Text Available Crystals of tricaesium scandium(III hexachloride were obtained as a side product from the reaction of U, SnCl2, Sc, and S in a CsCl flux at 1073 K. Cs3ScCl6 crystallizes in the Rb3YCl6 structure type. The asymmetric unit comprises three Cs sites, two Sc sites, and six Cl sites, all of which have site symmetry 1, except for the two Sc sites that have site symmetries of 2 and -1, respectively. The structure is composed of isolated [ScCl6]3− octahedra that are surrounded by Cs+ cations. Two Cs+ cations have interactions with eight Cl− anions, while the third has interactions with ten Cl− anions.

  17. Cs3ScCl6.

    Science.gov (United States)

    Ward, Matthew D; Ibers, James A

    2014-06-01

    Crystals of tricaesium scandium(III) hexa-chloride were obtained as a side product from the reaction of U, SnCl2, Sc, and S in a CsCl flux at 1073 K. Cs3ScCl6 crystallizes in the Rb3YCl6 structure type. The asymmetric unit comprises three Cs sites, two Sc sites, and six Cl sites, all of which have site symmetry 1, except for the two Sc sites that have site symmetries of 2 and -1, respectively. The structure is composed of isolated [ScCl6](3-) octa-hedra that are surrounded by Cs(+) cations. Two Cs(+) cations have inter-actions with eight Cl(-) anions, while the third has inter-actions with ten Cl(-) anions. PMID:24940185

  18. SC-FDMA for mobile communications

    CERN Document Server

    Abd El-Samie, Fathi E

    2013-01-01

    SC-FDMA for Mobile Communications examines Single-Carrier Frequency Division Multiple Access (SC-FDMA). Explaining this rapidly evolving system for mobile communications, it describes its advantages and limitations and outlines possible solutions for addressing its current limitations. The book explores the emerging trend of cooperative communication with SC-FDMA and how it can improve the physical layer security. It considers the design of distributed coding schemes and protocols for wireless relay networks where users cooperate to send their data to the destination. Supplying you with the re

  19. z206sc_video_observations

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents video observations from cruise Z206SC for the Santa Barbara Channel region and beyond in southern California. The vector data file is...

  20. z107sc_video_observations

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents video observations from cruise Z107SC for the Santa Barbara Channel region and beyond in southern California. The vector data file is...

  1. Structure and bonding of ScCN and ScNC: Ground and low-lying states

    International Nuclear Information System (INIS)

    Graphical abstract: The experimentally unknown systems ScCN and ScNC have been studied through single reference CISD and CCSD(T) methods. A total of 20 = 10 (ScCN) + 10 (ScNC) states were examined. All states are quite ionic whereas ScNC(X∼3Δ) is stabler than ScCN(X∼3Δ) by ∼5 kcal/mol. Display Omitted Highlights: ► We have studied through ab initio methods the polytopic system Sc[CN]. ► A series of low lying states for both isomeric forms have been examined. ► Around equilibrium the system displays a pronounced Sc+[CN]− ionic character. - Abstract: We have studied the experimentally unknown Sc[CN] molecular system in both its isomeric forms, scandium cyanide (ScCN) and isocyanide (ScNC), through ab initio computations. We report energetics, geometries, harmonic frequencies, and dipole moments for the first 20 Sc[CN] states correlating diabatically to Sc+(3D, 1D, 3F) + CN−(X1Σ+). Both isomers have a pronounced ionic character around equilibrium due to the high electron affinity of the CN group and the low ionization energy of the Sc atom. According to our calculations the ScNC isomer (X∼3Δ) is stabler than the ScCN(X∼3Δ) by ∼5 kcal/mol.

  2. Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

    OpenAIRE

    Richter, Wolfgang F; Bhansali, Suraj G.; Morris, Marilyn E.

    2012-01-01

    The subcutaneous (SC) route is of growing interest for the administration of biotherapeutics. Key products on the biotherapeutic market such as insulins, but also several immunoglobulins or Fc-fusion proteins, are administered SC. Despite the importance of the SC route, the available knowledge about the processes involved in the SC absorption of biotherapeutics is limited. This review summarizes available information on the physiology of the SC tissue and on the pharmacokinetic processes afte...

  3. 33 CFR 80.707 - Cape Romain, SC to Sullivans Island, SC.

    Science.gov (United States)

    2010-07-01

    ... Island, SC. 80.707 Section 80.707 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... to Sullivans Island, SC. (a) A line drawn from the western extremity of Cape Romain 292° true to... southernmost extremity of Bull Island to the easternmost extremity of Capers Island. (d) A line formed by...

  4. 33 CFR 80.712 - Morris Island, SC to Hilton Head Island, SC.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Morris Island, SC to Hilton Head Island, SC. 80.712 Section 80.712 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Seventh District § 80.712 Morris...

  5. Sc20C60: a volleyballene

    Science.gov (United States)

    Wang, Jing; Ma, Hong-Man; Liu, Ying

    2016-06-01

    An exceptionally stable hollow cage containing 20 scandium atoms and 60 carbon atoms has been identified. This Sc20C60 molecular cluster has a Th point group symmetry and a volleyball-like shape that we refer to below as ``Volleyballene''. Electronic structure analysis shows that the formation of delocalized π bonds between Sc atoms and the neighboring pentagonal rings made of carbon atoms is crucial for stabilizing the cage structure. A relatively large HOMO-LUMO gap (~1.4 eV) was found. The results of vibrational frequency analysis and molecular dynamics simulations both demonstrate that this Volleyballene molecule is exceptionally stable.An exceptionally stable hollow cage containing 20 scandium atoms and 60 carbon atoms has been identified. This Sc20C60 molecular cluster has a Th point group symmetry and a volleyball-like shape that we refer to below as ``Volleyballene''. Electronic structure analysis shows that the formation of delocalized π bonds between Sc atoms and the neighboring pentagonal rings made of carbon atoms is crucial for stabilizing the cage structure. A relatively large HOMO-LUMO gap (~1.4 eV) was found. The results of vibrational frequency analysis and molecular dynamics simulations both demonstrate that this Volleyballene molecule is exceptionally stable. Electronic supplementary information (ESI) available: Sc20C60: a Volleyballene_SI. See DOI: 10.1039/c5nr07784b

  6. K2SC: K2 Systematics Correction

    Science.gov (United States)

    Aigrain, Suzanne; Parviainen, Hannu; Pope, Benjamin

    2016-05-01

    K2SC (K2 Systematics Correction) models instrumental systematics and astrophysical variability in light curves from the K2 mission. It enables the user to remove both position-dependent systematics and time-dependent variability (e.g., for transit searches) or to remove systematics while preserving variability (for variability studies). K2SC automatically computes estimates of the period, amplitude and evolution timescale of the variability for periodic variables and can be run on ASCII and FITS light curve files. Written in Python, this pipeline requires NumPy, SciPy, MPI4Py, Astropy (ascl:1304.002), and George (ascl:1511.015).

  7. CORRELATION BETWEEN SEED TESTS AND FIELD EMERGENCE OF TWO MAIZE HYBRIDS (SC704 AND SC500

    Directory of Open Access Journals (Sweden)

    A.A. ALILOO

    2011-11-01

    Full Text Available Early emergence and stand establishment of maize (Zea mays L. are considered to be the most important yield-contributing factors. The influence of seed vigor on these factors is vital. Therefore, five laboratory tests and field experiment were conducted on basis of a randomized complete block design (RCBD with five replications in 2011, to evaluate the correlation among the seed vigor tests and field emergence of two maize hybrids (SC704 and SC500. In laboratory tests, differences between two hybrids for cold test and electrical conductivity test were significant (P≤0.01. The leachates of hybrid SC500 was 35% higher than the leachates of hybrid SC704. However, high germination percentage was obtained by hybrid SC740 in cold test. A Statistically significant difference was found between hybrids in field emergence percentage (P≤0.05. The field emergence of hybrid SC704 and hybrid SC500 was 71% and 37%, respectively. The farm emergence percentage had the significant negative correlation (-0.71 with conductivity test, but positive correlation (0.79 with cold test. No significant correlation between the standard seed germination and the field emergence was detected. Therefore, the standard germination test was not a good indicator for field emergence percentage. However, cold and conductivity tests were the best predictor of field emergence than all the other laboratory tests.

  8. Crystal structure and phase stability of AlSc in the near-equiatomic Al–Sc alloy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Juan; Huang, Li; Liang, Yongfeng [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing 100083 (China); Ye, Feng, E-mail: yefeng@skl.ustb.edu.cn [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing 100083 (China); Lin, Junpin [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing 100083 (China); Shang, Shunli; Liu, Zikui [Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802 (United States)

    2015-01-05

    Highlights: • Two lattice structures of equiatomic Al–Sc compounds are confirmed. • Al–Sc phase at Sc 50 at.% has a space group of Pbam. • Al–Sc phase at Sc 55 at.% has a space group of B2. • B2 AlSc is a metastable phase with Sc 50 at.%. • Lattice transition between two compounds is proposed under local thermal stress. - Abstract: Intermetallic compound AlSc is found in the equiatomic Al–Sc binary alloy. The present work indicates that the orthorhombic AlSc with the Au{sub 2}CuZn-type structure can be formed at 50 at.% Sc, while the CsCl-type (B2) AlSc will be formed at 55 at.% Sc. After annealing at 1100 °C, some orthorhombic AlSc grains transit to the B2 structure, and the annealing at lower temperatures leads to the disappearance of B2 phase, indicating that the B2 AlSc is also a metastable phase in the alloy at lower Sc content (<50 at.%). First-principle calculations at 0 K reveal that the orthorhombic AlSc is more stable than the B2 AlSc with the energy difference between them being 5.4 meV/atom. The fast transition between these two phases, which cannot be interpreted by the mechanism of atomic diffusion, was tentatively analyzed by the volume change based on the calculated atomic positions of these two phases.

  9. Precipitation hardening in ternary alloys of the Al-Sc-Cu and Al-Sc-Si systems

    International Nuclear Information System (INIS)

    The processes of precipitation hardening in cast ternary alloys of the Al-Sc-Cu and Al-Sc-Si systems were studied in the temperature range of aging from 100 to 450 C and at exposures to 200 h. It was shown that the CuAl2 and ScAl3 phases were involved in the process of aging in ternary Al-Sc-Cu alloys, and the Si and V (AlSiSc) phases, in ternary Al-Sc-Si alloys with excess silicon in a supersaturated solid solution. The V phase was for the first time revealed as the hardening phase in aluminum alloys

  10. Magnet measuring equipment of SC2

    CERN Multimedia

    1974-01-01

    Checking the positioning of the magnet measuring equipment installed between the poles of SC2. The steel structure in front of the magnet is designed to house the rotary condenser and to shield it from the stray magnetic field of the accelerator. On the left, Marinus van Gulik. (See Photo Archive 7402005 and Annual Report 1974, p. 44.)

  11. Magnet measuring equipment of SC2

    CERN Multimedia

    1974-01-01

    Checking the positioning of the magnet measuring equipment installed between the poles of SC2. The steel structure in front of the magnet is designed to house the rotary condenser and to shield it from the stray magnetic field of the accelerator.

  12. The Synchrocyclotron (SC) in building 300

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    The red magnet of CERN's first accelerator, the Synchrocyclotron (SC), has occupied a large part of Hall 300 since it was installed in the late 1950s. The remaining part of the 300-square-metre building has been used as a storage room since the accelerator was shut down in 1990. Now a public exhibition will breathe new life into the hall.

  13. Hemoglobin C, S-C, and E Diseases

    Science.gov (United States)

    ... Myeloma (Video) Multiple Myeloma Additional Content Medical News Hemoglobin C, S-C, and E Diseases By Alan E. ... Aplastic Anemia Autoimmune Hemolytic Anemia Sickle Cell Disease Hemoglobin C, S-C, and E Diseases Thalassemias Hemoglobin C, S- ...

  14. New tumor-associated antigen SC6 in pancreatic cancer

    OpenAIRE

    Liu, Min-Pei; Guo, Xiao-Zhong; Xu, Jian-Hua; Wang, Di; Li, Hong-Yu; Cui, Zhong-Min; Zhao, Jia-Jun; Ren, Li-Nan

    2005-01-01

    AIM: To examine the concentration of a new antigen SC6 (SC6-Ag) recognized by monoclonal antibody (MAb) in patients with pancreatic cancer and other malignant or benign diseases and to understand whether SC6-Ag has any clinical significance in distinguishing pancreatic cancer from other gastrointestinal diseases.

  15. Exponential decay for sc-gradient flow lines

    OpenAIRE

    Albers, Peter; Frauenfelder, Urs

    2013-01-01

    In this paper we introduce the notion of sc-action functionals and their sc-gradient flow lines. Our approach is inspired by Floer's unregularized gradient flow. The main result of this paper is that under a Morse condition sc-gradient flow lines have uniform exponential decay towards critical points. The ultimate goal for the future is to construct a M-polyfold bundle over a M-polyfold such that the space of broken sc-gradient flow lines is the zero set of a appropriate sc-section. Here unif...

  16. LHCb Data Replication During SC3

    CERN Multimedia

    Smith, A

    2006-01-01

    LHCb's participation in LCG's Service Challenge 3 involves testing the bulk data transfer infrastructure developed to allow high bandwidth distribution of data across the grid in accordance with the computing model. To enable reliable bulk replication of data, LHCb's DIRAC system has been integrated with gLite's File Transfer Service middleware component to make use of dedicated network links between LHCb computing centres. DIRAC's Data Management tools previously allowed the replication, registration and deletion of files on the grid. For SC3 supplementary functionality has been added to allow bulk replication of data (using FTS) and efficient mass registration to the LFC replica catalog.Provisional performance results have shown that the system developed can meet the expected data replication rate required by the computing model in 2007. This paper details the experience and results of integration and utilisation of DIRAC with the SC3 transfer machinery.

  17. The SC gets ready for visitors

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    Hall 300, which houses the Synchrocyclotron (SC), CERN’s first accelerator, is getting ready to host a brand-new exhibition. The site will be one of the stops on the new visit itineraries that will be inaugurated for the 2013 CERN Open Day.   The Synchrocyclotron through the years. Just as it did in the late 1950s, when the accelerator was first installed, the gigantic red structure of the Synchrocyclotron's magnet occupies a large part of the 300-square-metre hall. “We have completed the first phase of the project that will give the SC a new lease of life,” says Marco Silari, the project leader and a member of CERN’s Radiation Protection Group. “We have removed all the equipment that was not an integral part of the accelerator. The hall is now ready for the civil-engineering work that will precede the installation of the exhibition.” The SC was witness to a big part of the history of CERN. The accelerator produced ...

  18. Sc-47 production from titanium targets using electron linacs.

    Science.gov (United States)

    Mamtimin, Mayir; Harmon, Frank; Starovoitova, Valeriia N

    2015-08-01

    In this work we have studied the feasibility of photonuclear production of (47)Sc from (48)Ti via (48)Ti(γ,p)(47)Sc reaction. Photon flux distribution for electron beams of different energies incident on tungsten converter was calculated using MCNPX radiation transport code. (47)Sc production rate dependence on electron beam energy was found and (47)Sc yields were estimated. It was shown that irradiating a natural Ti target results in numerous scandium isotopes which can reduce the specific activity of (47)Sc. Irradiating enriched (48)Ti targets with a 22MeV 1mA beam will result in hundreds of MBq/g activity of (47)Sc and no other isotopes of scandium. Decreasing the size of the target will result in much higher average photon flux through the target and tens of GBq/g levels of specific activity of (47)Sc. Increasing the beam energy will also result in higher yields, but as soon as the electron energy exceeds the (48)Ti(γ,np)(46)Sc reaction threshold, (46)Sc starts being produced and its fraction in total scandium atoms grows as beam energy increases. The results of the simulations were benchmarked by irradiating natural titanium foil with 22MeV electron beam incident on the tungsten converter. Measured (47)Sc activities were found to be in very good agreement with the predictions. PMID:25931136

  19. Contraceptive efficacy and safety of DMPA-SC.

    Science.gov (United States)

    Jain, J; Jakimiuk, A J; Bode, F R; Ross, D; Kaunitz, A M

    2004-10-01

    DMPA-SC 104 mg/0.65 mL is a new, low-dose subcutaneous (SC) formulation of Depo-Provera contraceptive injection (150 mg/mL medroxyprogesterone acetate injectable suspension) that provides efficacy, safety and immediacy of onset equivalent to Depo-Provera intramuscular (IM) injection. Two large, open-label, Phase 3 studies assessed the 1-year contraceptive efficacy, safety and patient satisfaction with DMPA-SC administered every 3 months (12-13 weeks). Zero pregnancies were reported in both studies, which included a total of 16,023 woman-cycles of exposure to DMPA-SC and substantial numbers of overweight or obese women. DMPA-SC was well-tolerated and adverse events were similar to those reported previously with Depo-Provera IM. Thus, DMPA-SC offers women a new, highly effective and convenient long-acting contraceptive option. PMID:15451329

  20. SC response characteristics of two kinds of coagulant

    Institute of Scientific and Technical Information of China (English)

    杨万东; 宋爽; 史惠祥

    2002-01-01

    Automatic coagulant dosage control with streaming current (SC) technique is in troduced inthis paper. Aluminum and ferric coagulants are widely used in surface water treatment. The SC response characteristics of P-AiCI3 aluminum coagulant and P-FeCI3 ferric coagulant were investigated in this work. Bench-scale water treatment results were obtained from jar tests including rapid mixing,flocculation and undisturbed sedimentation. Results showed that aluminum coagulant is more sensitive than ferric coagulant to SC response.

  1. SC response characteristics of two kinds of coagulant

    Institute of Scientific and Technical Information of China (English)

    杨万东; 宋爽; 史惠祥

    2002-01-01

    Automatic coagulant dosage control with streaming current (SC) technique is introduced in this paper. Aluminum and ferric coagulants are widely used in surface water treatment. The SC response characteristics of P-AlCl3 aluminum coagulant and P-FeCl3 ferric coagulant were investigated in this work. Bench-scale water treatment results were obtained from jar tests including rapid mixing, flocculation and undisturbed sedimentation. Results showed that aluminum coagulant is more sensitive than ferric coagulant to SC response.

  2. Sc-47 production from titanium targets using electron linacs

    International Nuclear Information System (INIS)

    In this work we have studied the feasibility of photonuclear production of 47Sc from 48Ti via 48Ti(γ,p)47Sc reaction. Photon flux distribution for electron beams of different energies incident on tungsten converter was calculated using MCNPX radiation transport code. 47Sc production rate dependence on electron beam energy was found and 47Sc yields were estimated. It was shown that irradiating a natural Ti target results in numerous scandium isotopes which can reduce the specific activity of 47Sc. Irradiating enriched 48Ti targets with a 22 MeV 1 mA beam will result in hundreds of MBq/g activity of 47Sc and no other isotopes of scandium. Decreasing the size of the target will result in much higher average photon flux through the target and tens of GBq/g levels of specific activity of 47Sc. Increasing the beam energy will also result in higher yields, but as soon as the electron energy exceeds the 48Ti(γ,np)46Sc reaction threshold, 46Sc starts being produced and its fraction in total scandium atoms grows as beam energy increases. The results of the simulations were benchmarked by irradiating natural titanium foil with 22 MeV electron beam incident on the tungsten converter. Measured 47Sc activities were found to be in very good agreement with the predictions. - Highlights: • Optimum irradiation conditions of titanium targets were found. • MCNPX simulation and experimental results of Sc-47 yield are presented. • We demonstrated the feasibility of photonuclear production of Sc-47 from Ti-48

  3. A Realization of SC-CNN-Based Circuit Using FTFN

    OpenAIRE

    Günay, Enis; UZUNHİSARCIKLI, Esma; KILIÇ, Recai; ALÇI, Mustafa

    2005-01-01

    In this paper, a realization of the State Controlled Cellular Neural Network (SC-CNN)-based circuit using Four Terminal Floating Nullor (FTFN) as active element is presented. In this realization, a new version of autonomous Chua's circuit has been considered using FTFN realization of SC-CNN-based circuit. The performance of the proposed SC-CNN-based circuit is demonstrated by PSpice simulations.

  4. 3 SC for grid connected converters

    Energy Technology Data Exchange (ETDEWEB)

    Balogh, A.; Varga, E.; Varjasi, I. [Budapest Univ. of Technology and Economics, Budapest (Hungary). Dept. of Automation and Applied Informatics

    2008-07-01

    There are several grid connected converters in the modern grid system. They are usually converters for renewable energy sources, industrial 4 quadrant drives and other converters with direct current link. These converters are connected to the grid using a 3 phase bridge. Standards dictate the maximal harmonic emission and the maximal reactive current for the grid connected converters. For a converter working at nominal power, this means close to unity power factor. The harmonic emission could be limited with high switching frequency and/or with large harmonic filters. Additional financial issues are the efficiency, the small size and weight. Hardware solutions for increasing efficiency are being sought, although the energy required, especially the renewable energy, is expensive. Efficiency is one of the most important parameters of a grid connected system. The paper discussed the structure of the converter, standard control strategies, the three state control (3SC) method, and power factor correction with 3SC. Experimental results were also presented. It was concluded that with the new developed discontinuous current control, a high efficiency and reliable grid connected converter could be created, which satisfies the prescriptions and limitations of the standards. The auxiliary RPC control could make both inductive and capacitive reactive power and is able to inject current harmonics into the grid compensating the distortion of the grid voltage. 12 refs., 2 tabs.

  5. Toxicity, tissue distribution and excretion of 46ScCl3 and 46Sc-EDTA in mice

    International Nuclear Information System (INIS)

    The acute toxicity, differential distribution in tissue, and elimination of ScCl3, 46ScCl3, Sc-EDTA and 46Sc-EDTA, in mice, has been investigated. The LD50sup(24hr) doses for ScCl3 were 440 and 24 mg kg-1 respectively after intraperitioneal and intravenous injection, and 720 and 108 mg kg-1 respectively for Sc-EDTA. 46ScCl3 was extensively deposited in the liver and the spleen. 46Sc-EDTA was rapidly taken up by the kidney with subsequent elimation via the urine. While-body desaturation kinetics for 46Sc-EDTA were found to fit a three compartmental model. The fast elimination phase (T1/2 = 12.75 min; K = 0.05540 min-1) accounted for 74.6% of the dose; the intermediate phase (T1/2 = 40.2 min; K = 0.01722 min-1) for 21.8%, and the slow (T1/2 = 5351 min; K = 0.00013 min-1) for 3.6% of the dose. (author)

  6. Cyclotron production of {sup 44}Sc for clinical application

    Energy Technology Data Exchange (ETDEWEB)

    Krajewski, S.; Bilewicz, A. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cydzik, I. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection; Warsaw Univ. (Poland). Heavy Ion Lab.; Abbas, K. [European Commission Joint Research Center, Ispra (Italy). Institute for Transuranium Elements; Bulgheroni, A.; Simonelli, F.; Holzwarth, U. [European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection

    2013-08-01

    {sup 44} is a promising {beta}{sup +}-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc{sup 3+} to the Lu{sup 3+} and Y{sup 3+} cations, {sup 44}Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the {sup 177}Lu- and {sup 90}Y-bioconjugates, what is important in planning the radionuclide therapy. {sup 44}Sc can be obtained from the {sup 44}Ti/{sup 44}Sc generator. An alternative method for {sup 44}Sc production can be the irradiation of {sup 44}Ca target at small cyclotrons. The aim of our work was to optimize the parameters of {sup 44}CaCO{sub 3} irradiation and to develop a simple procedure for {sup 44}Sc separation from the calcium target. For optimization study, {sup 44}CaCO{sub 3} targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for {sup 44}Ca irradiations. A simple and fast separation procedure of {sup 44}Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced {sup 44}Sc. While {sup 44}CaCO{sub 3} is relatively expensive, the cost of {sup 44}Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of {sup 44}Sc, the availability of {sup 44}Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging. (orig.)

  7. Cyclotron production of 44Sc for clinical application

    International Nuclear Information System (INIS)

    44 is a promising β+-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc3+ to the Lu3+ and Y3+ cations, 44Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the 177Lu- and 90Y-bioconjugates, what is important in planning the radionuclide therapy. 44Sc can be obtained from the 44Ti/44Sc generator. An alternative method for 44Sc production can be the irradiation of 44Ca target at small cyclotrons. The aim of our work was to optimize the parameters of 44CaCO3 irradiation and to develop a simple procedure for 44Sc separation from the calcium target. For optimization study, 44CaCO3 targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for 44Ca irradiations. A simple and fast separation procedure of 44Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced 44Sc. While 44CaCO3 is relatively expensive, the cost of 44Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of 44Sc, the availability of 44Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging. (orig.)

  8. Sc III Spectral Properties of Astrophysical Interest

    CERN Document Server

    Nandy, D K; Sahoo, B K; Li, Chengbin

    2011-01-01

    Transition properties such as oscillator strengths, transition rates, branching ratios and lifetimes of many low-lying states in the doubly ionized scandium (Sc III) are reported. A relativistic method in the coupled-cluster framework has been employed to incorporate the electron correlations due to the Coulomb interaction to all orders by considering all possible singly and doubly excited electronic configurations conjointly with the contributions from the leading order triple excitations in a perturbative approach. Present results are compared with the previously available results for the transition lines of astrophysical interest and the role of the correlation effects are also discussed concisely. Some of the transition rates, oscillator strengths and lifetimes are acquainted.

  9. Cyclotron production of 44Sc: From bench to bedside

    International Nuclear Information System (INIS)

    Introduction: 44Sc, a PET radionuclide, has promising decay characteristics (T1/2 = 3.97 h, Eβ+av = 632 keV) for nuclear imaging and is an attractive alternative to the short-lived 68Ga (T1/2 = 68 min, Eβ+av = 830 keV). The aim of this study was the optimization of the 44Sc production process at an accelerator, allowing its use for preclinical and clinical PET imaging. Methods: 44CaCO3 targets were prepared and irradiated with protons (~ 11 MeV) at a beam current of 50 μA for 90 min. 44Sc was separated from its target material using DGA extraction resin and concentrated using SCX cation exchange resin. Radiolabeling experiments at activities up to 500 MBq and stability tests were performed with DOTANOC by investigating different scavengers, including gentisic acid. Dynamic PET of an AR42J tumor-bearing mouse was performed after injection of 44Sc-DOTANOC. Results: The optimized chemical separation method yielded up to 2 GBq 44Sc of high radionuclidic purity. In the presence of gentisic acid, radiolabeling of 44Sc with DOTANOC was achieved with a radiochemical yield of ~ 99% at high specific activity (10 MBq/nmol) and quantities which would allow clinical application. The dynamic PET images visualized increasing uptake of 44Sc-DOTANOC into AR42J tumors and excretion of radioactivity through the kidneys of the investigated mouse. Conclusions: The concept “from-bench-to-bedside” was clearly demonstrated in this extended study using cyclotron-produced 44Sc. Sufficiently high activities of 44Sc of excellent radionuclidic purity are obtainable for clinical application, by irradiation of enriched calcium at a cyclotron. This work demonstrates a promising basis for introducing 44Sc to clinical routine of nuclear imaging using PET

  10. Fermi surface study of ScAu2(Al, In) and ScPd2(Sn, Pb) compounds

    International Nuclear Information System (INIS)

    A detailed study on the electronic structure and Fermi surface (FS) of superconducting Heusler compounds ScAu2(Al, In) and ScPd2(Sn, Pb) has been carried out using first principles electronic structure calculations. The spin orbit coupling is found to play a major role in understanding the band structure and FS. Analysis of the data shows the importance of spin orbit coupling effect in the above compounds. The bands which cross Fermi level (EF) are found to be dominated by the Sc dt2g-states. The calculated total density of states are in good agreement with the experimentally reported value for ScPd2Sn. Under compression we find a change in the Fermi surface topology of ScPd2Sn at V/V0 = 0.95 (pressure of≈15 GPa), which is explained using the band structure calculations

  11. Structural Behavior of SC and RC Panels under Impact Loading

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyuk-Kee; Kim, Seung-Eock [Sejong University, Seoul (Korea, Republic of)

    2015-05-15

    NPP structures have been generally constructed using reinforced concrete (RC) structures. In recent studies, however, it has been confirmed that a steel-plate concrete (SC) structures has a much better impact resistance than an RC structure. In this paper, the impact resistance of SC and RC panels is evaluated using the commercial software LS-DYNA. To verify finite element (FE) models, the analysis results for SC and half steel-plate concrete panels under impact loading are compared with the test results conducted in other research. The impact analysis according to the different steel ratios with four different concrete thicknesses is performed in order to compare the impact resistance of SC and RC panels. To compare the impact resistance of SC and RC panels, the impact analysis was performed according to the different steel ratios with four different concrete thicknesses. Based on this study, the following conclusions have been obtained: (1) The rear face steel plate of SC panel plays more important role than the rear rebar of RC panel in preventing perforation. (2) When the perforation failure occurs, RC panel is more effective than SC panel to reduce the velocity of the missile.

  12. Pascal-SC a computer language for scientific computation

    CERN Document Server

    Bohlender, Gerd; von Gudenberg, Jürgen Wolff; Rheinboldt, Werner; Siewiorek, Daniel

    1987-01-01

    Perspectives in Computing, Vol. 17: Pascal-SC: A Computer Language for Scientific Computation focuses on the application of Pascal-SC, a programming language developed as an extension of standard Pascal, in scientific computation. The publication first elaborates on the introduction to Pascal-SC, a review of standard Pascal, and real floating-point arithmetic. Discussions focus on optimal scalar product, standard functions, real expressions, program structure, simple extensions, real floating-point arithmetic, vector and matrix arithmetic, and dynamic arrays. The text then examines functions a

  13. Gadolinium scandium germanide, Gd2Sc3Ge4

    Directory of Open Access Journals (Sweden)

    Sumohan Misra

    2009-04-01

    Full Text Available Gd2Sc3Ge4 adopts the orthorhombic Pu5Rh4-type structure. The crystal structure contains six sites in the asymmetric unit: two sites are statistically occupied by rare-earth atoms with Gd:Sc ratios of 0.967 (4:0.033 (4 and 0.031 (3:0.969 (3, one site (.m. symmetry is occupied by Sc atoms, and three distinct sites (two of which with .m. symmetry are occupied by Ge atoms. The rare-earth atoms form two-dimensional slabs with Ge atoms occupying the trigonal-prismatic voids.

  14. Gadolinium scandium germanide, Gd2Sc3Ge4

    OpenAIRE

    Sumohan Misra; Miller, Gordon J.

    2009-01-01

    Gd2Sc3Ge4 adopts the orthorhombic Pu5Rh4-type structure. The crystal structure contains six sites in the asymmetric unit: two sites are statistically occupied by rare-earth atoms with Gd:Sc ratios of 0.967 (4):0.033 (4) and 0.031 (3):0.969 (3), one site (.m. symmetry) is occupied by Sc atoms, and three distinct sites (two of which with .m. symmetry) are occupied by Ge atoms. The rare-earth atoms form two-dimensional slabs with Ge atoms occupying the tri...

  15. New tumor-associated antigen SC6 in pancreatic cancer

    Institute of Scientific and Technical Information of China (English)

    Min-Pei Liu; Xiao-Zhong Guo; Jian-Hua Xu; Di Wang; Hong-Yu Li; Zhong-Min Cui; Jia-Jun Zhao; Li-Nan Ren

    2005-01-01

    AIM: To examine the concentration of a new antigen SC6 (SC6-Ag) recognized by monoclonal antibody (MAb)in patients with pancreatic cancer and other malignant or benign diseases and to understand whether SC6-Ag has any clinical significance in distinguishing pancreatic cancer from other gastrointestinal diseases.METHODS: Six hundred and ninety-five serum specimens obtained from 115 patients with pancreatic cancer, 154 patients with digestive cancer and 95patients with non-digestive cancer were used and classified in this study. Serum specimens obtained from 140 patients with benign digestive disease and 89 patients with non-benign digestive disease served as controls. Ascites was tapped from 16 pancreatic cancer patients, 19 hepatic cancer patients, 16 colonic cancer patients, 10 gastric cancer and 6 severe necrotic pancreatitis patients. The samples were quantitated by solid-phase radioimmunoassay. The cut-off values (CV)of 41, 80, and 118 U/mL were used.RESULTS: The average intra- and interassay CV detected by immunoradiometric assay of SC6-Ag was 5.4% and 8.7%, respectively. The sensitivity and specificity were 73.0% and 90.9% respectively. The levels in most malignant and benign cases were within the normal upper limit. Among the 16 pancreatic cancer cases, the concentration of SC6-Ag in ascites was over the normal range in 93.8% patients. There was no significant difference in the concentration of SC6-Ag.Decreased expression of SC6-Ag in sera was significantly related to tumor differentiation. The concentration of SC6-Ag was higher in patients before surgery than after surgery. The specificity of SC6-Ag and CA19-9 was significantly higher than that of ultrasound and computer tomography (CT) in pancreatic cancer patients. Higher positive predictive values were indicated in 92.3% SC6-Ag and 88.5% CA19-9, but lower in 73.8% ultrasound and 76.2% CT.CONCLUSION: The combined test of SC6-Ag and CA19-9 may improve the diagnostic rate of primary cancer. The detection of

  16. NMR investigation of intermetallic compound FeΛ2Sc

    International Nuclear Information System (INIS)

    Structure, macro- and microscopic magnetic properties of Fe12Sc intermetallides are studied. The structure of compounds has been determined roentgenographically using FeKsub(α) irradiation. NMR measurements have been carried out at 4.2 77 and 293 K and structure measurements - at 293 K. Fe2Sc samples magnetation, measured with the help of vibrational manometer in the 9 kOe field and in the temperature range from 293-1000 K, is equal to approximately 400 Gs (measurement accuracy approximately 3%). Curie temperature for Fe2Sc is determined according to the point of magnetization curve decay bend at high temperatures. Analysis of NMR spectra is carried out

  17. Precipitation in cold-rolled Al-Sc-Zr and Al-Mn-Sc-Zr alloys prepared by powder metallurgy

    KAUST Repository

    Vlach, Martin

    2013-12-01

    The effects of cold-rolling on thermal, mechanical and electrical properties, microstructure and recrystallization behaviour of the AlScZr and AlMnScZr alloys prepared by powder metallurgy were studied. The powder was produced by atomising in argon with 1% oxygen and then consolidated by hot extrusion at 350 C. The electrical resistometry and microhardness together with differential scanning calorimetry measurements were compared with microstructure development observed by transmission and scanning electron microscopy, X-ray diffraction and electron backscatter diffraction. Fine (sub)grain structure developed and fine coherent Al3Sc and/or Al3(Sc,Zr) particles precipitated during extrusion at 350 C in the alloys studied. Additional precipitation of the Al3Sc and/or Al3(Sc,Zr) particles and/or their coarsening was slightly facilitated by the previous cold rolling. The presence of Sc,Zr-containing particles has a significant antirecrystallization effect that prevents recrystallization at temperatures minimally up to 420 C. The precipitation of the Al6Mn- and/or Al 6(Mn,Fe) particles of a size ~ 1.0 μm at subgrain boundaries has also an essential antirecrystallization effect and totally suppresses recrystallization during 32 h long annealing at 550 C. The texture development of the alloys seems to be affected by high solid solution strengthening by Mn. The precipitation of the Mn-containing alloy is highly enhanced by a cold rolling. The apparent activation energy of the Al3Sc particles formation and/or coarsening and that of the Al6Mn and/or Al 6(Mn,Fe) particle precipitation in the powder and in the compacted alloys were determined. The cold deformation has no effect on the apparent activation energy values of the Al3Sc-phase and the Al 6Mn-phase precipitation. © 2013 Elsevier Inc.

  18. IEC SC15E: Report on liaison activities of CIGRÉ-SC15

    DEFF Research Database (Denmark)

    Henriksen, Mogens

    2000-01-01

    WG’s activities under CIGRÉ SC15:WG 15.01 - Fluid impregnated systems.WG 15.02 - Dielectric Liquids.WG 15.03 - Gas Insulation.WG 15.04 - Outdoor Insulation.WG 15.05 - Capacitors.WG 15.07 - Solid Insulating Materials for Rotating Machines.WG 15/33.08 - Insulation Monitoring and Life Estimation. WG...... 15.09 - Advanced Materials.WG 15.10 - Internal Insulation and Interfaces.WG 15.11 - Service-Aged Materials.WG 15.12 - DC Insulation/Space Charge Measurements....

  19. Design of SC walls and slabs for impulsive loading

    Energy Technology Data Exchange (ETDEWEB)

    Varma, Amit H. [Purdue Univ., West Lafayette, IN (United States)

    2015-11-11

    Reinforced concrete (RC) structures have historically been the preferred choice for blast resistant structures because of their mass and the ductility provided by steel reinforcement. Steel-plate composite (SC) walls are a viable alternative to RC for protecting the infrastructure against explosive threats. SC structures consist of two steel faceplates with a plain concrete core between them. The steel faceplates are anchored to the concrete using stud anchors and connected to each other using tie bars. SC structures provide mass from the concrete infill and ductility from the continuous external steel faceplates. This dissertation presents findings and recommendations from experimental and analytical investigations of the performance of SC walls subjected to far-field blast loads.

  20. Development of SC structure modularization in Nuclear Power Plant

    International Nuclear Information System (INIS)

    New Focus on NPP are Rising Concerns on Global Warming, Potential energy crisis (geo-political), Improved reliability and safety of nuclear power plant, Advent of Generation 3+ NPP technology and Economical Energy Resource. New NPPs are 6 units in Korea and 23 in Asia being built, 32 units being planned in China by 2020 (150 by 2050), 10 units being planned in US by 2020 and IAEA expects $200 billions on NPP construction next 25 years (up to 30% of total world energy). □ SC(Steel Plate Concrete) structure · Steel Plate is used as a Structural Element instead of Reinforcing Bars in RC · SC structure consists of Steel Plate with Headed Studs. Connected by Tie-bars - The Primary Purpose of Tie-bars is to Stiffen and Hold Together the Plates during Construction Process - Headed Studs are Welded to the Inside of Steel Plate for composite action □ Benefits of SC Structure · Shorten Construction Duration for Re bar, Forming and Scaffolding Works · Minimize Site Labors · Improve the Construction Quality · Enable Construction Sites to be kept Clean □ SC Modularization · Fit for Modular Construction for Structural Features · Fit for Modular Construction for Structural Features · Inattentively Effective for Integrated Modules · Pre-fabrication, Pre-assembly and Modularization □ Project Overview · Project Name: Development of SC structure for Modularization in NPP · Project Type: Electric Power Industry R and D (Ministry of Knowledge Economy) · Duration: Sep. 2005 ∼ Aug. 2008 (36 Months) · Research Team and Scopes - Project Management: Korea Hydro and Nuclear Power Company (KHNP) - Development of Code and Standards for SC Structure: Korea Society of Steel Construction (KSSC) Korea Electric Power Research Institute (KEPRI) - Development of SC Structural Analysis and Design: Korea Power Engineering Company (KOPEC) - Development of Construction Techniques for SC Modularization: KHNP, Korea Institute of Nuclear Safety(KINS), KOPEC □ Performance

  1. Parametric Study of SC Panel Subjected to Impact Loading

    International Nuclear Information System (INIS)

    FE analysis with impact test for small scale structure is necessary, because it is impossible to perform full scale test for safety assessment of NPP structures. Analysis factors such as erosion value, strain rate effect, and material model of concrete and steel can influence the analysis results. In this paper, the effects of concrete fracture energy and erosion in material model on FE results of SC panel subjected to impact loading are evaluated using a commercial program LS-DYNA. The analysis results are compared with impact test for SC panel conducted by other researchers. Parametric studies were performed to evaluate the structural behavior of SC panels according to the fracture energy of concrete and erosion values of concrete and steel. Based on these studies, the following conclusions have been obtained : SC panel with an applied erosion value of ±7% for tension and compression of concrete agreed well with the test result. The erosion of steel had not influenced structural behavior, because the failure mode of SC panel is non-perforation mode. SC panel using the concrete fracture energy of 0.152N/mm corresponding to the maximum aggregate size of 32mm showed a good agreement with the test result

  2. Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

    OpenAIRE

    Huang, Emina H.; Hynes, Mark J.; Zhang, Tao; Ginestier, Christophe; Dontu, Gabriela; Appelman, Henry; Fields, Jeremy Z.; Wicha, Max S.; Boman, Bruce M

    2009-01-01

    Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identification and isolation of SC from normal and malignant colon. Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a possible marker for identifying colonic SC and for tra...

  3. Unexpected magnetic behavior in amorphous Co90Sc10 alloy

    International Nuclear Information System (INIS)

    An amorphous alloy Co90Sc10 has been prepared by rapid quenching from the melt. The results of magnetization measurements show that this alloy has the highest Curie temperature reported for any amorphous transition metal based alloys. Furthermore, for a Co based amorphous alloy, the magnetic moment is remarkably high. Moreover, the alloy exhibits soft magnetic properties. Based on the findings, amorphous Co90Sc10 appears to be an attractive candidate for applications as a soft magnetic material. The temperature dependence of the reduced magnetization can be described by the Bloch power law. The results show that the B coefficient of the amorphous Co90Sc10 alloy, which is a measure of the rigidity of spin waves, exhibits the lowest value observed until now for any amorphous alloy and is comparable to crystalline alloys. It is found that the Sc atoms in the Co90Sc10 alloy lead to an increase of the itinerant spin moment of Co atoms, and, in contrast to this behaviour, to a decrease of the local 3d-electrons of Co

  4. Ab-initio studies of the Sc adsorption and the ScN thin film formation on the GaN(000-1)-(2 × 2) surface

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero-Sánchez, J., E-mail: guerrero@ifuap.buap.mx [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Sánchez-Ochoa, F.; Cocoletzi, Gregorio H.; Rivas-Silva, J.F. [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Takeuchi, Noboru [Universidad Nacional Autónoma de México, Centro de Nanociencia y Nanotecnología, Apartado Postal 2681, Ensenada, Baja California 22800 (Mexico)

    2013-12-02

    First principles total energy calculations have been performed to investigate the initial stages of the Sc adsorption and ScN thin film formation on the GaN(000-1)-(2 × 2) surface. Studies are done within the periodic density functional theory as implemented in the PWscf code of the Quantum ESPRESSO package. The Sc adsorption at high symmetry sites results in the bridge site as the most stable structure. When a Sc monolayer is deposited above the surface the T4 site results as the most stable geometry. The Sc migration into the first Ga monolayer induces the Ga displaced ad-atom to be adsorbed at the T4-2 site. A ScN bilayer may be obtained under the Ga monolayer. Finally a ScN bilayer may be formed in the wurtzite phase above the surface. The formation energy plots show that in the moderate Ga-rich conditions we obtain the formation of a ScN bilayer under the gallium monolayer. However at N-rich conditions the formation of ScN bilayer above the surface is the most favorable structure. We report the density of states to explain the electronic structure of the most favorable geometries. - Highlights: • Studies of the initial stages in the formation of Sc and ScN structures on GaN • In the adsorption of Sc on the GaN the Br site is the most favorable geometry. • When a Sc replaces a Ga of the first monolayer the displaced Ga occupies a T4-2 site. • For Ga-rich conditions there is formation of ScN under the Ga monolayer. • In N-rich conditions there is formation of ScN in the wurtzite phase.

  5. Scénarios : représentations et usages

    OpenAIRE

    Pernin, Jean-Philippe; Villiot-Leclercq, Emmanuelle

    2006-01-01

    Cet article présente les premiers résultats d'une enquête sur la scénarisation pédagogique menée auprès des acteurs du monde éducatif (enseignants, chercheurs, ingénieurs pédagogiques, formateurs, responsables de formation) et initiée dans le cadre du projet CAUSA. Il vise à présenter l'outil de collecte, un questionnaire, élaboré pour recueillir des données sur les caractéristiques des praticiens impliqués dans la scénarisation, leurs représentations générales sur le concept de scénario, et ...

  6. Transport of one SC coil through the village of Meyrin

    CERN Multimedia

    1956-01-01

    In 1952, before CERN was officially founded, two accelerator projects were launched: one for an innovative accelerator to operate at an energy level unequalled at the time, the other for a more standard machine, a Synchro-Cyclotron (SC) to operate at 600 MeV. Design work on the SC was started in 1952 and carried out by teams scattered throughout Europe. Once construction began in 1954, CERN had to arrange road transport for the first of what has since been a long series of spectacular component deliveries, such as those of the machine's two magnetic coils each weighing 60 tonnes and measuring 7.2 metres in diameter. Above, one of them is seen passing through the village of Meyrin. The SC was commissioned in 1957 and was operational for 34 years!

  7. Experience with OpenMP 1 for MADX-SC

    CERN Document Server

    D’Imperio, N; Yu, K; Kapin, V; McIntosh, E; Renshall, H; Schmidt, F

    2014-01-01

    MADX-SC [1–3] allows the treatment of frozen space charge using beam-beam elements in a thin lattice, i.e. one can take advantage of the standard set-up of MAD-X [4] lattices without the need for specialized codes for the space-charge (SC) evaluation. The idea is to simulate over many turns without the problem of noise as in the PIC 1 SC codes. For the examples under study, like the PS and RHIC, it would be desirable to simulate up to 1 million turns or more. To this end one had to make an effort to optimize the scalar speed and, most importantly, get a speed-up of approximately a factor of 5 using OpenMP [5].

  8. Experience with OpenMP for MADX-SC

    Energy Technology Data Exchange (ETDEWEB)

    D' Imperio, Nicholas [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Montag, Christophe [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Yu, Kwangmin [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Kapin, Valery [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); McIntosh, Eric [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Renshall, Harry [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Schmidt, Frank [European Organization for Nuclear Research (CERN), Geneva (Switzerland)

    2014-07-01

    MADX-SC allows the treatment of frozen space charge using beam-beam elements in a thin lattice, i.e. one can take advantage of the standard set-up of MAD-X lattices without the need for specialized codes for the space-charge (SC) evaluation. The idea is to simulate over many turns without the problem of noise as in the PIC SC codes. For the examples under study, like the PS and RHIC, it would be desirable to simulate up to 1 million turns or more. To this end one had to make an effort to optimize the scalar speed and, most importantly, get a speed-up of approximately a factor of 5 using OpenMP.

  9. Thermoelectric performance of functionalized Sc 2 C MXenes

    KAUST Repository

    Kumar, S.

    2016-07-05

    Functionalization of the MXene Sc2C, which has the rare property to realize semiconducting states for various functionalizations including O, F, and OH, is studied with respect to the electronic and thermal behavior. The lowest lattice thermal conductivity is obtained for OH functionalization and an additional 30% decrease can be achieved by confining the phonon mean free path to 100 nm. Despite a relatively low Seebeck coefficient, Sc2C(OH)2 is a candidate for intermediate-temperature thermoelectric applications due to compensation by a high electrical conductivity and very low lattice thermal conductivity.

  10. Low-β SC linacs: past, present, and future

    International Nuclear Information System (INIS)

    This paper is a general review of superconducting low-β technology and applications from its beginning in 1969 into the near-term future. The emphasis is on studies of accelerating resonators and on SC linacs that boost the energy of heavy-ion beams from tandem electrostatic accelerators used for nuclear-physics research. Other topics are positive-ion SC injectors to replace tandems and the need for accelerating structures with β outside of the present proven range, 0.008 < β < 0.2

  11. Product policy of SC Electrecord S.A.

    Directory of Open Access Journals (Sweden)

    Ph. D. Candidate Cristina Andreescu (Manolache

    2009-12-01

    Full Text Available The global brand has the advantage of the scale economy, facilitates the company image and prestige and sometimes benefits even from its origin country effect. Its use is quite difficult (the semantic variations can impede the use of the same brand. The international brands act as a restriction against standardisation (the product should not be differentiated as there are internationally accepted and recognized brands. This paper makes an overview description of the general market environment, but also of the arket environment of SC ELECTRECORD S.A.; it underlines the product characteristics as well as the commercial diagnosis within SC ELECTRECORD S.A.

  12. Yield measurements in the reactions 48Ca(p,γ)49Sc and 48Ca(p,n)48Sc

    International Nuclear Information System (INIS)

    Absolute cross sections for the reactions 48Ca(p,γ)49Sc and 48Ca(p,n)48Sc have been measured for proton bombarding energies from 0.76 MeV to 2.20 MeV. The results are in satisfactory agreement with predictions of the Hauser-Feshback statistical model of nuclear reactions. In particular, the predicted flattening out of the (p,γ) cross section above the threshold for the (p,n3) channel is consistent with the data

  13. SC-CO2 as green solvent for chemoenzymatic reaction

    Czech Academy of Sciences Publication Activity Database

    Zarevúcka, Marie; Sovová, Helena; Wimmer, Zdeněk

    Bari : ACE, 2004. s. -. [European Meeting on Environmental Chemistry /5./. 15.12.2004-18.12.2004, Bari] R&D Projects: GA ČR GA203/04/0120 Keywords : chemoenzymatic reaction * SC-CO2 Subject RIV: CC - Organic Chemistry

  14. 78 FR 62001 - South Carolina Disaster #SC-00024

    Science.gov (United States)

    2013-10-10

    ... ADMINISTRATION South Carolina Disaster SC-00024 AGENCY: U.S. Small Business Administration. ACTION: Notice...: 07/07/2014. ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration... CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409 3rd Street...

  15. Toelating Herbasan SC welkom voor dahlia, A. coronaria en narcis

    NARCIS (Netherlands)

    Leeuwen, van P.J.; Koster, A.T.J.; Trompert, J.P.T.

    2005-01-01

    Onlangs is Herbasan SC voor de onkruidbestrijding in onder meer dahlia, narcis en Anemone coronaria toegelaten. PPO ging na hoe het middel het beste is in te zetten. In dit artikel zijn de resultaten van het onderzoek vermeld en een advies voor toepassing

  16. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering....

  17. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    The catalogue contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...... projects at the M.Sc. programme in Civil and Structural Engineering....

  18. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    Clausen, Johan

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...... projects at the M.Sc. programme in Civil and Structural Engineering....

  19. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    This catalogue contains a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering....

  20. 75 FR 71734 - Outer Continental Shelf (OCS), Scientific Committee (SC)

    Science.gov (United States)

    2010-11-24

    ... of field and laboratory studies in biology, chemistry, and physical oceanography, as well as studies... archaeology; and physical oceanography. The selections are based on maintaining disciplinary expertise in all... disciplines of the biological, physical, chemical, and socioeconomic sciences. Currently, the OCS SC has...

  1. Electrochemical Characterization of Ni/(Sc)YSZ Electrodes

    DEFF Research Database (Denmark)

    Ramos, Tania; Thydén, Karl Tor Sune; Mogensen, Mogens Bjerg

    2010-01-01

    Investigations of Ni/(Sc)YSZ cermets for solid oxide cells (SOCs) were performed by electrochemical impedance spectroscopy (EIS), under varying experimental conditions and upon redox cycling, using three different designs of symmetric cells. The deconvolution and fitting of the obtained impedance...

  2. Adaptive Synchronization of Chaotic SC-CNN with Uncertain State Template

    OpenAIRE

    2015-01-01

    The problem of synchronization of chaotic State Controlled Cellular Neural Network (SC-CNN) with uncertain state template is investigated. In detail, the following three cases are solved: firstly, synchronization of two identical chaotic SC-CNNs with uncertain state template, secondly, synchronization of two nonidentical chaotic SC-CNNs with all uncertain state templates, and, thirdly, synchronization between chaotic SC-CNN with uncertain state template and different uncertain parameter chaot...

  3. Crystal fields of dilute Tb, Dy, or Er in Sc obtained by magnetization measurements

    DEFF Research Database (Denmark)

    Høg, J.; Touborg, P.

    1976-01-01

    Crystal-field parameters for dilute Sc-Tb, Sc-Dy, and Sc-Er alloys have been obtained by fitting theoretical expressions to the experimentally measured paramagnetic susceptibility. The initial susceptibility was measured and corrected for the effects of ordering at the lowest temperatures in the...

  4. Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae.

    Science.gov (United States)

    Gan, Zhen; Chen, Shannan; Hou, Jing; Huo, Huijun; Zhang, Xiaolin; Ruan, Baiye; Laghari, Zubair Ahmed; Li, Li; Lu, Yishan; Nie, Pin

    2016-07-01

    PGRP-SC2, the member of PGRP family, plays an important role in regulation of innate immune response. In this paper, a PGRP-SC2 gene of Nile tilapia, Oreochromis niloticus (designated as On-PGRP-SC2) was cloned and its expression pattern under the infection of Streptococcus agalactiae was investigated. Sequence analysis showed main structural features required for amidase activity were detected in the deduced amino acid sequence of On-PGRP-SC2. In healthy tilapia, the On-PGRP-SC2 transcripts could be detected in all the examined tissues, with the most abundant expression in the muscle. When infected with S. agalactiae, there was a clear time-dependent expression pattern of On-PGRP-SC2 in the spleen, head kidney and brain. The assays for the amidase activity suggested that recombinant On-PGRP-SC2 protein had a Zn(2+)-dependent PGN-degrading activity. Moreover, our works showed that recombinant On-PGRP-SC2 protein could significantly reduce bacterial load in target organs attacked by S. agalactiae. These findings indicated that On-PGRP-SC2 may play important roles in the immune response to S. agalactiae in Nile tilapia. PMID:27033804

  5. Advanced fusion reactor design using remountable HTc SC magnet

    International Nuclear Information System (INIS)

    A new concept of fusion reactor design is proposed using remountable high critical temperature (HTc) superconducting (SC) magnet. There are two advantages using this system. First one is that the magnet system can be composed by parts, which means it easy to replace the damaged magnet module. The second one is that it becomes possible to access the reactor first wall easily. In order to realize this system, we have performed experiments using HTc SC tape. The experimental results indicate that the resistance of the jointed region becomes about 60 μΩ, which shows the feasibility of this concept. Using this system the remountable first wall system also has the feasibility based on thermomechanical analysis. (author)

  6. Development and applicability analysis of ATHLET-SC code

    International Nuclear Information System (INIS)

    Research activities of supercritical water reactor (SCWR) have been carried out worldwide,aiming at cost reduction by system simplification and higher thermal efficiency. One of the most important tasks for the design and assessment of SCWR performance is to develop system analysis codes which are applicable under supercritical conditions. The paper presents the development of new system analysis code ATHLET-SC based on ATHLET 2.1A. Thermo-physical properties package valid for supercritical conditions are implemented into the existing ATHLET code to extend its application to safety analysis of SCWR. In to evaluate the applicability of the modified code, a core calculation model of mixed SCWR(SCWR-M) was proposed and analyzed, and transients of core power were simulated. Moreover, a simplified supercritical water cooled loop was proposed and its stability behaviors were analyzed. The results achieved up to now indicate a good applicability of the modified ATHLET code (ATHLET-SC) in simulation of SCWR. (authors)

  7. Structural, elastic and thermodynamic properties of Ti2SC

    Indian Academy of Sciences (India)

    Hongzhi Fu; Wenfang Liu; Tao Gao

    2011-12-01

    The structural parameters, elastic constants and thermodynamic properties of Ti2SC were investigated under pressure and temperature by using first-principles plane-wave pseudopotential density functional theory within the generalized gradient approximation. The obtained results are in agreement with the available experimental data. The bulk moduli along the - and -axes, $B_{a}$ and $B_{c}$, almost linearly increase with pressure, and the former is always smaller than the latter. The ratio of $B_{c}/B_{a}$ has a trend of gradual increase as the pressure increases. It is found that the elastic constants, anisotropy and Debye temperature of Ti2SC increase with pressure, while axial compressibility along the - and -axes decreases with pressure. The thermal properties including the equation of state, the Grüneisen parameter , the anisotropies $\\Delta_{p}, \\Delta_{S1}$ and $\\Delta_{S2}$, and the heat capacity are estimated at various pressures and temperatures.

  8. Status of Simulation Tools for the ILD ScECAL

    CERN Document Server

    Kotera, Katsushige; Boudry, Vincent; Brient, Jean-Claude; Jeans, Daniel; Kawagoe, Kiyotomo; Miyamoto, Akiya; de Freitas, Paulo Mora; Musat, Gabriel; Ono, Hiroaki; Takeshita, Tohru; Uozumi, Satoru

    2010-01-01

    The scintillator-strip electromagnetic calorimeter (ScECAL) is one of the calorimeter technic for the ILC. To achieve the fine granularity from the strip-segmented layers the strips in odd layers are orthogonal with respect to those in the even layers. In order to extract the best performance from such detector concept, a special reconstruction method and simulation tools are being developed in ILD collaboration. This manuscript repots the status of developing of those tools.

  9. Conceptual Design of the TPF-O SC Buses

    Science.gov (United States)

    Purves, Lloyd R.

    2007-01-01

    The Terrestrial Planet Finder - Occulter (TPF-O) mission has two Spacecraft (SC) buses, one for a space telescope and the other for a formation-flying occulter. SC buses typically supply the utilities (support structures, propulsion, attitude control, power, communications, etc) required by the payloads. Unique requirements for the occulter SC bus are to provide the large delta V required for the slewing maneuvers of the occulter, and comunications for formation flying. The TPF-O telescope SC bus shares some key features of the one for the Hubble Space Telescope (HST): both support space telescopes designed to observe in the visible to near infrared range of wavelengths with comparable primary mirror apertures (2.4 m for HST, 2.4 - 4.0 m for TPF-O). However, TPF-O is expected to have a Wide Field Camera (WFC) with a Field of View (FOV) much larger than that of HST. Ths WFC is also expected to provide fine guidance. TPF-O is designed to operate in an orbit around the Sun-Earth Lagrange 2 (SEL2) point. The longer communications range to SEL2 and the large science FOV require higher performance communications than HST. Maintaining a SEL2 orbit requires TPF-O, unlike HST, to have a propulsion system. The velocity required for reachng SEL2 and the limited capabilities of affordable launch vehicles require both TPF-O elements to have compact, low-mass designs. Finally, it is possible that TPF-O may utilize a modular design derived fiom that of HST to allow servicing in the SEL2 orbit.

  10. CoopSC: A Cooperative Database Caching Architecture

    OpenAIRE

    Vancea, A; Stiller, B.

    2010-01-01

    Semantic caching is a technique used for optimizing the evaluation of database queries by caching results of old queries and using them when answering new queries. CoopSC is a cooperative database caching architecture, which extends the classic semantic caching approach by allowing clients to share their local caches in a cooperative matter. Cache entries of all clients are indexed in a distributed data structure constructed on top of a Peer-to-Peer (P2P) overlay netwo...

  11. SC2: Secure Communication over Smart Cards

    DEFF Research Database (Denmark)

    Dragoni, Nicola; Lostal, Eduardo; Papini, Davide;

    2012-01-01

    card hosting the application. In this paper we address a key issue to realize the S×C idea, namely the outsourcing of the contractpolicy matching service to a Trusted Third Party (TTP). In particular, we present the design and implementation of (SC)2 (Secure Communication over Smart Cards), a system...... securing the communication between a smart card and the TTP which provides the S×C matching service....

  12. Local Collision Simulation of an SC Wall Using Energy Absorbing Steel

    International Nuclear Information System (INIS)

    This study evaluates the local damage of a turbine in an auxiliary building of a nuclear power plant due to an external impact by using the LS-DYNA finite element program. The wall of the auxiliary building is SC structure and the material of the SC wall plate is high manganese steel, which has superior ductility and energy absorbance compared to the ordinary steel used for other SC wall plates. The effects of the material of the wall, collision speed, and angle on the magnitude of the local damage were evaluated by local collision analysis. The analysis revealed that the SC wall made of manganese steel had significantly less damage than the SC wall made of ordinary steel. In conclusion, an SC wall made of manganese steel can have higher effective resistance than an SC wall made of ordinary steel against the local collision of an airplane engine or against a turbine impact

  13. Performance Analysis of OFDM 60GHz System and SC-FDE 60GHz System

    Directory of Open Access Journals (Sweden)

    Han Xueyan

    2016-01-01

    Full Text Available In this paper, the performance of 60GHz wireless communication system with SC and OFDM is studied, the models of OFDM 60GHz system and SC 60GHz frequency domain equalization (SC-FDE system are established, and the bit error rate (BER performance of OFDM 60GHz system and SC-FDE 60GHz system in 802.15.3c channels is compared. The simulation results show that SC-FDE 60GHz system has a slight advantage over OFDM system in line-of-sight (LOS channels, while OFDM 60GHz system has a slight advantage over SC-FDE system in non-line-of-sight (NLOS channels. For 60GHz system, OFDM 60GHz system has a slight advantage over SC-FDE system in overcoming multipath fading, but the performance of both is close whether in the LOS or NLOS case.

  14. QUALITY MANAGEMENT OF BAKERY PRODUCTS: A CASE STUDY IN SC

    Directory of Open Access Journals (Sweden)

    Nicoleta- Luminiţa STRÂMBEANU RISTEA

    2013-01-01

    Full Text Available The paper aimed to present the benefits of implementing HACCP (Hazard Analysis and Critical Control Points to company S.C. "DOBRE AND SONS" S.R.L. Constanta, Romania. The data have been provided by the above mentioned manufacturer. The objectives of S.C. "DOBRE AND SONS" S.R.L. are protecting the health of the consumers of the products and their satisfaction regarding the consumption of products that are nutritional, tasty, fresh, free from microbiological, chemical and physical hazard, as well as possessing stable properties during the validity for consumption. In this respect, there has been implemented and maintained an integrated management system of food quality and safety according to SR EN ISO 9001:2008, SR EN ISO 22000:2005 and according to IFS standard, version 5/2007, which consists of determining the potential biological, chemical and physical hazards that might affect the safety of bread and bakery products, or the health of the consumer. HACCP team is analyzing hazard using one of the recommended techniques: brainstorming or the cause - effect diagram. In conclusion, the company S.C. "DOBRE AND SONS" S.R.L. Constanta, Romania provides awareness and employee involvement at all levels in achieving the appointed objectives.

  15. Conceptual design of SC linac for RIBF-upgrade plan

    International Nuclear Information System (INIS)

    For the intensity upgrade of very-heavy ions such as 238U and 124Xe at the RIKEN RI-Beam Factory (RIBF), a design study of new SC linac injector has started on. In the RIBF, the very-heavy ions are accelerated in a cascade of the injector linac (RILAC2), the RIKEN ring cyclotron (RRC), the fixed-frequency ring cyclotron (fRC), the intermediate-stage ring cyclotron (IRC), and the world's first superconducting ring cyclotron (SRC). We plan to substitute the SC linac for the RRC with respect to the very heavy ions, and to boost up the energy of ions with mass-to-charge ratio of 7 from 1.4 MeV/u to 11 MeV/u in the cw mode. The SC cavity is assumed to be a two gap QWR with an rf frequency of 73 MHz, that is twice the rf frequency of IRC and SRC. (author)

  16. Scandium(iii) complexes of monophosphorus acid DOTA analogues: a thermodynamic and radiolabelling study with (44)Sc from cyclotron and from a (44)Ti/(44)Sc generator.

    Science.gov (United States)

    Kerdjoudj, R; Pniok, M; Alliot, C; Kubíček, V; Havlíčková, J; Rösch, F; Hermann, P; Huclier-Markai, S

    2016-01-19

    The complexation ability of DOTA analogs bearing one methylenephosphonic (DO3AP) or methylenephosphinic (DO3AP(PrA) and DO3AP(ABn)) acid pendant arm toward scandium was evaluated. Stability constants of their scandium(iii) complexes were determined by potentiometry combined with (45)Sc NMR spectroscopy. The stability constants of the monophosphinate analogues are somewhat lower than that of the Sc-DOTA complex. The phosphorus acid moiety interacts with trivalent scandium even in very acidic solutions forming out-of-cage complexes; the strong affinity of the phosphonate group to Sc(iii) precludes stability constant determination of the Sc-DO3AP complex. These results were compared with those obtained by the free-ion selective radiotracer extraction (FISRE) method which is suitable for trace concentrations. FISRE underestimated the stability constants but their relative order was preserved. Nonetheless, as this method is experimentally simple, it is suitable for a quick relative comparison of stability constant values under trace concentrations. Radiolabelling of the ligands with (44)Sc was performed using the radioisotope from two sources, a (44)Ti/(44)Sc generator and (44m)Sc/(44)Sc from a cyclotron. The best radiolabelling conditions for the ligands were pH = 4, 70 °C and 20 min which were, however, not superior to those of the parent DOTA. Nonetheless, in vitro behaviour of the Sc(iii) complexes in the presence of hydroxyapatite and rat serum showed sufficient stability of (44)Sc complexes of these ligands for in vivo applications. PET images and ex vivo biodistribution of the (44)Sc-DO3AP complex performed on healthy Wistar male rats showed no specific bone uptake and rapid clearance through urine. PMID:26675416

  17. The microstructure, optical, and electrical properties of sol-gel-derived Sc-doped and Al-Sc co-doped ZnO thin films

    International Nuclear Information System (INIS)

    Transparent conductive ZnO:Al-Sc (1:0.5, 1:1, 1:1.5 at.% Al-Sc) thin films were prepared on glass substrates by sol-gel method. The microstructure, optical, and electrical properties of ZnO:Sc and ZnO:Al-Sc films were investigated. Results show that Sc-doping alone obviously decreases grain size and degrades the crystallinity; there is an amorphous phase on the surface of ZnO grains; the transmittance spectra fluctuate dramatically with a large absorption valley at about 430-600 nm. However, Al-Sc co-doping can stabilize grain size and improve the microstructure; an average visible transmittance of above 73% is obtained with no large absorption valley; the amorphous phase does not appear. The optical band gaps of ZnO:Sc and ZnO:Al-Sc films (3.30-3.32 eV) are blue-shifted relative to pure ZnO film (3.30 eV). Hall effects show that the lowest resistivity of 2.941 x 10-2 Ω cm and the maximum Hall mobility of 24.04 cm2/V s are obtained for ZnO:Al-Sc films while ZnO:Sc films do not exhibit any electrical conductivity. Moreover, there is an optimum atomic ratio with Al to Sc of 1:0.5-1 at.%. Although the resistivities are increased compared with that of ZnO:Al film, the Hall mobilities are raised by one order of magnitude.

  18. Core energy levels of Sc and N and their variation with coordination number in ScN

    Czech Academy of Sciences Publication Activity Database

    Šimůnek, Antonín; Vackář, Jiří; Kunc, K.

    2005-01-01

    Roč. 72, č. 4 (2005), 045110/1-045110/4. ISSN 1098-0121 R&D Projects: GA AV ČR(CZ) IAA100100514; GA AV ČR(CZ) IAA1010317 Grant ostatní: NATO(XE) PST -CLG.979025 Institutional research plan: CEZ:AV0Z10100520; CEZ:AV0Z10100521 Keywords : core levels * total energy * ScN Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.185, year: 2005

  19. Electrochemical formation of Sc-Al intermetallic compounds in the eutectic LiCl-KCl. Determination of thermodynamic properties

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • The formation mechanism of AlxScy intermetallic compounds was studied in the eutectic LiCl-KCl • The formation energy, global and consecutive formation constants of AlxScy were estimated from OCP. • XRD after potentiostatic electrolysis, allowed the identification of Al3Sc and Al2Sc • XRD after intermittent galvanostatic electrolysis allowed the identification of Al3Sc, Al2Sc and AlSc2 • SEM with EDX, allowed the identification of Al3Sc, Al2Sc, AlSc and AlSc2. - Abstract: The electrochemical formation of Sc-Al alloys was investigated in the eutectic LiCl-KCl by cyclic voltammetry and open circuit chronopotentiometry. On reactive Al electrode the electrochemical reduction of Sc(III) was observed at less cathodic potential values than at the surface of an inert W electrode, the potential shift is caused by the decrease of Sc activity in the metal phase due to the formation of Sc-Al intermetallic compounds at the interface. The formation mechanism of the intermetallic compounds was studied in a melt containing: (i) both Sc(III) and Al(III) ions, using a W electrode, and ii) Sc(III) ions using an Al electrode. Analysis of the samples after electrolysis runs by X-ray diffraction allowed the identification of Al3Sc and Al2Sc, whereas analysis by scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS), allowed the identification of Al3Sc, Al2Sc, AlSc and AlSc2. The formation energy of each AlxScy intermetallic compound, and the global and stepwise formation constant were estimated from open circuit chronopotentiometry measurements in the eutectic LiCl-KCl at 723 and 773 K using Al as working electrode

  20. Microstructure evolution of the 1469 Al–Cu–Li–Sc alloy during homogenization

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Min, E-mail: jm_lushan@163.com; Zheng, Ziqiao, E-mail: csu1469@163.com; Gong, Zhu, E-mail: start123gz@163.com

    2014-11-25

    Highlights: • The formation of the W phase (AlCuSc) was found in the 1469 Al-Cu–Li–Sc alloy. • The W phase formed during the homogenization process. • We model the formation process of the W phase. • The formation of the W phase consumes lots of Cu and Sc atoms. - Abstract: The present work aims to clarify the formation of the W phase (AlCuSc) and its formation time in the high Cu content alloy with Sc addition. The microstructure evolution during the two-step homogenization annealing process was investigated in the 1469 Al–Cu–Li–Sc alloy. No evidences of the Al{sub 3}Sc phase and the W phase were found in the solidification structure. The arrays of the W phases were found to form after homogenization. The AlCu phases with traces of Sc that formed during solidification suppose to be the precursor of the W phases, and then transform into the W phases by consuming the Sc atoms that fixed in the supersaturate solid solution. The formation of the W phase inhibits the precipitation of the Al{sub 3}Sc phase. A corresponding model of the W phase formation mechanism is proposed.

  1. Competition of ferromagnetism and superconductivity in Sc3InB

    International Nuclear Information System (INIS)

    We present results of electronic structure calculations for the intermetallic perovskite Sc3InB with the full-potential KKR-LDA method. Sc3InB is a very promising candidate for a new superconductor (related to 8 K MgCNi3) and can be regarded as a boron-inserted cubic Sc3In, which is a high-pressure allotropic form of the hexagonal weak ferromagnet Sc3In. We predict that cubic Sc3In can also be magnetic, whereas Sc3InB having large DOS in the vicinity of EF exhibits non-magnetic ground state. Estimation of the electron-phonon coupling for Sc3InB gives λ≅1. Furthermore, the effect of vacancies in Sc3InB1-x and antisite disorder in Sc3(In-B) on critical parameters is also discussed using the KKR-CPA method. All theoretical results support the possibility of the superconductivity onset in Sc3InB. Preliminary experimental measurements established the transition temperature close to 4.5 K, with a very abrupt change in susceptibility and a correlated drop of the resistivity when cooling. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  2. Prof. dr. sc. Ivo Miše: 1981. - 2001.

    OpenAIRE

    Knežević, Goran

    2001-01-01

    Dne 17. ožujka 2001. prošlo je dvadeset godina od smrti prof. dr. sc. Ive Miše predstojnika katedre za oralnu kirurgiju i jednog od dekana Stomatološkog fakulteta Sveučilišta u Zagrebu. Današnji naraštaji studenata Stomatološkog fakulteta čuli su za njegovo ime preko knjige “Oralna kirurgija”, koju su nakon Miπiše smrti izdali njegovi suradnici i koja je imala tri izdanja, a mnogi pak današnji mlađi djelatnici Fakulteta nisu ga imali prilike upoznati.

  3. Wind power characterization in the Lages city - SC, Brazil

    OpenAIRE

    Olívio José Soccol; Danieli Bariviera Zitterell; Mario Nestor Ullmann; David José Miquelluti

    2010-01-01

    The main objective of this work was to determinate the nominal wind and the wind power, based on mathematical adjustments in the Lages city, SC-Brazil. The study used data comprising the period between 1976 and 2006. The wind average velocity was osted by Lages Meteorological Station located at 27º49'S, 50º12' W, and 937 meters of altitude. For the estimated wind temporal distribution, a methodology based on wind velocity curves was used. The nominal velocity that made wind power maximum in L...

  4. The calculated rovibronic spectrum of scandium hydride, ScH

    CERN Document Server

    Lodi, Lorenzo; Tennyson\\, Jonathan

    2015-01-01

    The electronic structure of six low-lying electronic states of scandium hydride, $X\\,{}^{1}\\Sigma^+$, $a\\,{}^{3}\\Delta$, $b\\,{}^{3}\\Pi$, $A\\,{}^{1}\\Delta$ $c\\,{}^{3}\\Sigma^+$, and $B\\,{}^{1}\\Pi$, is studied using multi-reference configuration interaction as a function of bond length. Diagonal and off-diagonal dipole moment, spin-orbit coupling and electronic angular momentum curves are also computed. The results are benchmarked against experimental measurements and calculations on atomic scandium. The resulting curves are used to compute a line list of molecular ro-vibronic transitions for $^{45}$ScH.

  5. Hecke Algebras, SVD, and Other Computational Examples with {\\sc CLIFFORD}

    OpenAIRE

    Ablamowicz, Rafal

    1999-01-01

    {\\sc CLIFFORD} is a Maple package for computations in Clifford algebras $\\cl (B)$ of an arbitrary symbolic or numeric bilinear form B. In particular, B may have a non-trivial antisymmetric part. It is well known that the symmetric part g of B determines a unique (up to an isomorphism) Clifford structure on $\\cl(B)$ while the antisymmetric part of B changes the multilinear structure of $\\cl(B).$ As an example, we verify Helmstetter's formula which relates Clifford product in $\\cl(g)$ to the Cl...

  6. Scalable Implementation of Finite Elements by NASA _ Implicit (ScIFEi)

    Science.gov (United States)

    Warner, James E.; Bomarito, Geoffrey F.; Heber, Gerd; Hochhalter, Jacob D.

    2016-01-01

    Scalable Implementation of Finite Elements by NASA (ScIFEN) is a parallel finite element analysis code written in C++. ScIFEN is designed to provide scalable solutions to computational mechanics problems. It supports a variety of finite element types, nonlinear material models, and boundary conditions. This report provides an overview of ScIFEi (\\Sci-Fi"), the implicit solid mechanics driver within ScIFEN. A description of ScIFEi's capabilities is provided, including an overview of the tools and features that accompany the software as well as a description of the input and output le formats. Results from several problems are included, demonstrating the efficiency and scalability of ScIFEi by comparing to finite element analysis using a commercial code.

  7. A 45Sc-NMR and DFT calculation study of crystalline scandium compounds

    Science.gov (United States)

    Bräuniger, Thomas; Hofmann, Andreas J.; Moudrakovski, Igor L.; Hoch, Constantin; Schnick, Wolfgang

    2016-01-01

    A series of scandium compounds, namely ScPO4, ScOF, Li3Sc(BO3)2, and CaSc2O4, were prepared according to procedures described in the literature, and then characterised by powder X-ray diffraction and solid-state 45Sc-NMR spectroscopy. By computer fitting, the quadrupolar interaction parameters χ and η, as well as the isotropic chemical shifts δiso were extracted from the NMR spectra. For comparison and site assignment of 45Sc, density functional theory (DFT) calculations of the EFG tensor were carried out with the CASTEP code. For the compounds with a well-defined formal coordination number (CN), a convincing linear correlation between CN and isotropic chemical shift could be established.

  8. Toward low-cost affinity reagents: lyophilized yeast-scFv probes specific for pathogen antigens.

    Directory of Open Access Journals (Sweden)

    Sean A Gray

    Full Text Available The generation of affinity reagents, usually monoclonal antibodies, remains a critical bottleneck in biomedical research and diagnostic test development. Recombinant antibody-like proteins such as scFv have yet to replace traditional monoclonal antibodies in antigen detection applications, in large part because of poor performance of scFv in solution. To address this limitation, we have developed assays that use whole yeast cells expressing scFv on their surfaces (yeast-scFv in place of soluble purified scFv or traditional monoclonal antibodies. In this study, a nonimmune library of human scFv displayed on the surfaces of yeast cells was screened for clones that bind to recombinant cyst proteins of Entamoeba histolytica, an enteric pathogen of humans. Selected yeast-scFv clones were stabilized by lyophilization and used in detection assay formats in which the yeast-scFv served as solid support-bound monoclonal antibodies. Specific binding of antigen to the yeast-scFv was detected by staining with rabbit polyclonal antibodies. In flow cytometry-based assays, lyophilized yeast-scFv reagents retained full binding activity and specificity for their cognate antigens after 4 weeks of storage at room temperature in the absence of desiccants or stabilizers. Because flow cytometry is not available to all potential assay users, an immunofluorescence assay was also developed that detects antigen with similar sensitivity and specificity. Antigen-specific whole-cell yeast-scFv reagents can be selected from nonimmune libraries in 2-3 weeks, produced in vast quantities, and packaged in lyophilized form for extended shelf life. Lyophilized yeast-scFv show promise as low cost, renewable alternatives to monoclonal antibodies for diagnosis and research.

  9. Conductivity ageing studies on 1M10ScSZ (M4+=Ce, Hf)

    DEFF Research Database (Denmark)

    Omar, Shobit; Bin Najib, Waqas; Bonanos, Nikolaos

    2011-01-01

    The long-term conductivity stability is tested on zirconia based electrolyte materials for solid oxide fuel cell applications. The ageing studies have been performed on the samples of ZrO2 co-doped with 10mol% of Sc2O3 and 1mol% MO2, where M = Ce or Hf (denoted respectively 1Ce10ScSZ and 1Hf10Sc...

  10. Model of Dees and Rotco for the 600 MeV SC

    CERN Multimedia

    1978-01-01

    The accelerating frequency of the 600 MeV Synchro-Cyclotron (SC) was modulated by the varying capacity of a rotating condenser ("Rotco", the most delicate component of the SC). A 1/5-scale model, dating from the design-period of the SC, was used to study improvements to the SC RF-system, and also the acceleration of ions, first Helium and, at the time of this picture, Carbon. In the middle of the picture is the case containing the Dees. To the left, at the wide end of the cone, a rotco. Reinhold Hohbach is busy with measurements. See also 7805235 (Annual Report 1978, p.110).

  11. Ferromagnetism carried by highly delocalized hybrid states in Sc-doped ZnO thin films

    KAUST Repository

    Benali Kanoun, Mohammed

    2012-05-29

    We present first-principles results for Sc-doped ZnOthin films. Neighboring Sc atoms in the surface and/or subsurface layers are found to be coupled ferromagnetically, where only two of the possible configurations induce spin polarization. In the first configuration, the polarization is carried by the Sc d states as expected for transition metaldoping. However, there is a second configuration which is energetically favorable. It is governed by polarized hybrid states of the Zns, O p, and Sc d orbitals. Such highly delocalized states can be an important ingredient for understanding the magnetism of dopedZnOthin films.

  12. Characterization of PrP(Sc) transmission from immune cells to neuronal cells.

    Science.gov (United States)

    Tanaka, Yufuko; Sadaike, Tetsuji; Inoshima, Yasuo; Ishiguro, Naotaka

    2012-10-01

    We investigated PrP(Sc) transmission in neuronal cells, spleen cells and several immune cells using an in vitro cell-to-cell transmission system. The transmission of PrP(Sc) in the supernatant of PrP(Sc)-infected neuronal cells was also investigated. We found that PrP(Sc) transmission was more efficient in the cell-to-cell transmission system than in the supernatant-mediated system. PrP(Sc) was more efficiently transmitted from adherent spleen cells to neuronal cells than from floating spleen cells. The adherent spleen cells were composed of macrophages (80%), dendritic cells (8%) and follicular dendritic cells (3%), indicating that macrophages play an important role in PrP(Sc) transmission from immune cells to neuronal cells. Although PrP(Sc) in the immune cells used as donor cells was gradually degraded, the PrP(Sc) transmitted to neuronal cells was observed by Western blot analysis. Investigation of the mechanism of PrP(Sc) transmission between cells represents an important step towards understanding the pathogenesis of prion diseases. PMID:23246505

  13. Formation Processes of Nanocomposite Strengthening Particles in Rapidly Quenched Al-Sc-Zr Alloys

    OpenAIRE

    A.V. Kotko; Nosenko, V. K.; O.A. Molebny; T.O. Monastyrska; A.L. Berezina

    2012-01-01

    Decomposition processes of supersaturated solid solution of aluminium alloys alloyed with Sc and Zr have been studied in the work. The binary hypereutectic Al-Sc alloys, hyperperitectic Al-Zr alloys and ternary Al-Sc-Zr alloys were chosen. Alloys were obtained by the melt-spinning. Melts were quenched from temperatures of Т = 1000 C and Т = 1400 ºC. The study of the structure of rapidly solidifyed binary Al alloys alloyed with Sc and Zr showed that the crystallization of anomalously supersat...

  14. SC&RA颁发最佳起重运输奖%SC&RA picks best jobs in rigging and hauling

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

      美国特种搬运和吊装协会(SC&RA)2007年4月10日至14日在圣安东尼奥Westin La Contera Resort饭店召开的年会上,评出了本年度的"最佳起重运输作业奖".这一奖项的出台再一次奖将人们的目光集中到美国最大和最佳的起重运输作业项目上.……

  15. Summary of the Space Charge Workshop 2013 (SC-13)

    CERN Document Server

    Franchetti, G

    2013-01-01

    This report summarizes the disucssions and conclusions from the "Space Charge 2013" (SC-13) workshop at CERN, 16-19 April 2013. SC-13 was jointly organized by EUCARD, ACCNET, ICFA, HIC4FAIR and LIU. Strong activities on space-charge related topics are ongoing at CERN (LIU), GSI (FAIR), and RAL (ISIS upgrade). Several studies include experimental work. The issue of code benchmarking is important with regard to long-term tracking. In particular, the noise created by PIC codes evoked intense discussions. Interesting from a theoretical stand point has been a discussion about equating PIC noise with intrabeam-scattering. A decision has been taken to use the GSI test suite for benchmarking of frozen space charge models also for the benchmarking of PIC codes. Firm plans have been made to benchmark Synergia and Orbit, plus perhaps also IMPACT and WARP. Other discussion focused on the role of GPU for high intensity beam dynamics. Corresponding efforts were reported from GSI, RAL, and FNAL. The final consensus is that ...

  16. Carbon K-edge polarimetry with Cr/Sc multilayers

    International Nuclear Information System (INIS)

    We investigate the polarization changes simultaneously occurring with intensity changes due to carbon contamination of optical components at two plane grating beam lines PGM-1 and PGM-2 at BESSY II. The two beam lines are very similar to each other and connect to the same APPLE II type undulator UE56/2. The spectra measured with initial horizontal and vertical polarization differ for the two beam lines. For polarimetry measurements the BESSY 8-axis polarimeter is equipped with a Cr/Sc multilayer in transmission as phase retarder and a Cr/Sc reflecting multilayer operating near the Brewster angle as analyzer. The polarimetry results also differ for the two beam lines. Only at PGM-2 we observe no decline of the degree of polarization within experimental errors i.e. the degree of polarization at PGM-2 is always found P > 0.96. We find big changes of the polarization which rapidly vary across the carbon edge. A tentative interpretation predicts the orientation of the dipoles in the contaminating carbon layers. Circular polarization is largely recovered (80% and higher) at PGM-2 thru out the carbon edge by setting the undulator shift to approximately compensate the polarizing properties of the beam line.

  17. The first SC-SAGD pilot in the Grosmont

    Energy Technology Data Exchange (ETDEWEB)

    Solanki, S.C.; Barrett, K.; Riva, D.; Becker, L.; Brindle, G. [Laricina Energy Ltd. (Canada)

    2011-07-01

    In north-eastern Alberta, the Grosmont Formation is an Upper Devonian carbonate succession containing a vast amount of bitumen. In an attempt to exploit this resource, Laricina Energy Ltd. and OSUM Oil Sands Corp. built the first ever solvent-cyclic steam-assisted gravity drainage (SC-SAGD) pilot. In this process, solvent and/or steam are continuously injected at reservoir pressure to heat the reservoir and thus reduce bitumen viscosity. The aim of this paper is to present the pilot project and its initial results. The reservoir's geology, the recovery process, the drilling and completion challenges as well as the design and the operational plan are discussed in this paper. Steam injection started in December 2010 and indications show that the wells are progressing as planned. Results showed an uptime greater than 90% so far and this is expected to further improve in the future. The first SC-SAGD pilot is discussed and early phases showed excellent results from the project.

  18. V-ATPase, ScNhxlp and Yeast Vacuole Fusion

    Institute of Scientific and Technical Information of China (English)

    Quan-Sheng Qiu

    2012-01-01

    Membrane fusion is the last step in trafficking pathways during which membrane vesicles fuse with target organelles to deliver cargos.It is a central cellular reaction that plays important roles in signal transduction,protein sorting and subcellular compartmentation.Recent progress in understanding the roles of ion transporters in vacuole fusion in yeast is summanzed in this article.It is becoming increasingly evident that the vacuolar proton pump V-ATPase and vacuolar Na+/H+ antiporter ScNhxlp are key components of the vacuole fusion machinery in yeast.Yeast ScNhxlp regulates vacuole fusion by controlling the luminal pH.V-ATPases serve a dual role in vacuolar integrity in which they regulate both vacuole fusion and fission reactions in yeast.Fission defects are epistatic to fusion defects.Vacuole fission depends on the proton translocation activity of the V-ATPase; by contrast,the fusion reaction does not need the transport activity but requires the physical presence of the proton pump.Vo,the membrane-integral sector of the V-ATPase,forms trans-complexes between the opposing vacuoles in the terminal phase of vacuole fusion where the Vo trans-complexes build a continuous proteolipid channel at the fusion site to mediate the bilayer fusion.

  19. 48Sc as a calibration source for the SNO+ experiment

    International Nuclear Information System (INIS)

    SNO+ (Sudbury Neutrino Observatory Plus Scintillator) is the successor of the SNO experiment, and currently under construction near Sudbury, Canada. Located in a mine 2000 m underground (equivalent to a shielding of about 6000 m of water), SNO+ will be a low-background experiment studying different aspects of neutrinos. Several sources will be employed for the detector's calibration, which is scheduled to start in mid-2013. One of the sources under development at TU Dresden uses the γ rays following the β decay of 48Sc. The sum of the γ energies for the main decay branch is close to the Q value of the double beta decay of 150Nd, which is planned to be measured in the second phase of SNO+. Due to the half life of only 43.67(9) h, 48Sc has to be produced shortly before the calibration. Safety, radiopurity and cleanliness are further important issues for the application of a source in a low-background experiment like SNO+. The design of the source, its production and the current status of its development are presented.

  20. scFv噬菌体库分离特异性的人源化抗D-dimer抗体%Isolation of specific humanized anti-D-dimer scFv fragments from scFv phage libraries

    Institute of Scientific and Technical Information of China (English)

    夏红利; 谭最; 陈德杰; 乔建国; 邱仁峰

    2011-01-01

    目的 从scFv(单链Fv)噬菌体抗体库分离出对D-dimer有特异性的人源化单克隆scFv.方法 对Tomlinson scFv噬菌体文库进行3轮淘洗,富集特异性的抗D-dimer抗体并进行ELISA 验证.通过酶联免疫检测和双脱氧终止法基因测序,获取特异性的人源化单克隆抗体.结果 3轮淘洗选择出38个抗D-dimer噬菌体抗体,酶联免疫和基因测序分析后,20个不同的全长单克隆抗D-dimer scFv噬菌体抗体被筛选出来,3轮选择后阳性克隆获取率为100%;分泌性抗体ELISA结果显示单克隆anti-D-dimer噬菌体顺利表达了抗体蛋白;5个A450值较高的单克隆中,3个显示了对D-dimer的高特异性和亲和力.结论 抗体噬菌体展示技术是分离获取人源化特异性anti-D-dimer抗体的高效快速方法.%Objective To isolate specific humanized anti-D-dimer scFv(single chain Fv) antibody from scFv phage libraries. Methods Isolate anti-D-dimer positive clones from Tomlinson I + J phage libraries by three rounds of panuing, then sequence monoclonal genes by bideoxy-mediated chain termination and express soluble scFv antibody; Pick out anti-D-dimer antibodies with high specificity and affinity by ELISA.Results After three rounds of selection from human scFv phage libraries Tomlinson I and J, 38 monclonal specific anti-D-dimer scFv fragments were selected. By polyclonal and monoclonal phage ELISA and gene sequencing, 20 different full-length monoclonal scFv phages were identified, the result of soluble scFv ELISA showed that 20 full-length monoclonal scFv were expressed smoothly. According to the result of soluble scFv ELISA, in 5 scFv antibodies with high value of A450 selected, 3 scFv antibody fragments showed high specific and affinity. Conclusion Antibody phage display was an effective, rapid method to isolate anti-D-dimer antibodies with high specificity and affinity.

  1. Baculovirus display of single chain antibody (scFv using a novel signal peptide

    Directory of Open Access Journals (Sweden)

    Gonzalez Gaëlle

    2010-11-01

    Full Text Available Abstract Background Cells permissive to virus can become refractory to viral replication upon intracellular expression of single chain fragment variable (scFv antibodies directed towards viral structural or regulatory proteins, or virus-coded enzymes. For example, an intrabody derived from MH-SVM33, a monoclonal antibody against a conserved C-terminal epitope of the HIV-1 matrix protein (MAp17, was found to exert an inhibitory effect on HIV-1 replication. Results Two versions of MH-SVM33-derived scFv were constructed in recombinant baculoviruses (BVs and expressed in BV-infected Sf9 cells, N-myristoylation-competent scFvG2/p17 and N-myristoylation-incompetent scFvE2/p17 protein, both carrying a C-terminal HA tag. ScFvG2/p17 expression resulted in an insoluble, membrane-associated protein, whereas scFvE2/p17 was recovered in both soluble and membrane-incorporated forms. When coexpressed with the HIV-1 Pr55Gag precursor, scFvG2/p17 and scFvE2/p17 did not show any detectable negative effect on virus-like particle (VLP assembly and egress, and both failed to be encapsidated in VLP. However, soluble scFvE2/p17 isolated from Sf9 cell lysates was capable of binding to its specific antigen, in the form of a synthetic p17 peptide or as Gag polyprotein-embedded epitope. Significant amounts of scFvE2/p17 were released in the extracellular medium of BV-infected cells in high-molecular weight, pelletable form. This particulate form corresponded to BV particles displaying scFvE2/p17 molecules, inserted into the BV envelope via the scFv N-terminal region. The BV-displayed scFvE2/p17 molecules were found to be immunologically functional, as they reacted with the C-terminal epitope of MAp17. Fusion of the N-terminal 18 amino acid residues from the scFvE2/p17 sequence (N18E2 to another scFv recognizing CD147 (scFv-M6-1B9 conferred the property of BV-display to the resulting chimeric scFv-N18E2/M6. Conclusion Expression of scFvE2/p17 in insect cells using a BV

  2. Effect of interfacial solute segregation on ductile fracture of Al–Cu–Sc alloys

    International Nuclear Information System (INIS)

    Three-dimensional atom probe analysis is employed to characterize the Sc segregation at θ′/α-Al interfaces in Al–2.5 wt.% Cu–0.3 wt.% Sc alloys aged at 473, 523 and 573 K, respectively. The interfacial Sc concentration is quantitatively evaluated and the change in interfacial energy caused by Sc segregation is assessed, which is in turn correlated to yield strength and ductility of the alloys. The strongest interfacial Sc segregation is generated in the 523 K-aged alloy, resulting in an interfacial Sc concentration about 10 times greater than that in the matrix and a reduction of ∼25% in interfacial energy. Experimental results show that the interfacial Sc segregation promotes θ′ precipitation and enhances the strengthening response. A scaling relationship between the interfacial energy and precipitation strengthening increment is proposed to account for the most notable strengthening effect observed in the 523 K-aged alloy, which is ∼2.5 times that in its Sc-free counterpart and ∼1.5 times that in the 473 and 573 K-aged Al–Cu–Sc alloys. The interfacial Sc segregation, however, causes a sharp drop in the ductility when the precipitate radius is larger than ∼200 nm in the 523 K-aged alloy, indicative of a transition in fracture mechanisms. The underlying fracture mechanism for the low ductility regime, revealed by in situ transmission electron microscopy tensile testing, is that interfacial decohesion occurs at the θ′ precipitates ahead of crack tip and favorably aids the crack propagation. A micromechanical model is developed to rationalize the precipitate size-dependent transition in fracture mechanisms by taking into account the competition between interfacial voiding and matrix Al rupture that is tailored by interfacial Sc segregation

  3. Synthesis and Crystal Structure of La3ScBi5%La3ScBi5的合成与晶体结构

    Institute of Scientific and Technical Information of China (English)

    潘大春; 孙忠明; 雷晓武; 毛江高

    2006-01-01

    在氩气保护下,将金属单质置于钽管中进行高温固相反应得到了一个新的三元极性金属间化合物,La3ScBi5.通过X-射线单晶衍射确定了它的晶体结构.La3ScBi5晶体属六方晶系,空间群为P63/mcm(No.193),晶胞参数为:a=b=0.97573(5)nm,c=0.65592(6)nm,V=0.54341(9)nm3,Z=2.La3ScBi5属反式Hf5Sn3Cu结构类型,其结构特征为Bi的一维直线链和由ScBi6八面体之间通过共面形成的{ScBi3}链.能带计算表明La3ScBi5呈金属导电性.%The new ternary phase, La3ScBi5 was obtained by the high temperature solid-state reactions of the pure metal elements in welded Ta tubes under argon atmosphere. Its structure was established by single-crystal X-ray diffraction. The title compound crystallizes in the hexagonal space group P63/mcm (No.193) with cell parameters of a=b=0.975 73(5) nm, c=0.655 92(6) nm, V=0.543 41(9) nm3, and Z=2. The structure of La3ScBi5 belongs to the "anti" Hf5Sn3Cu type, and features 1D linear Bi chains and {ScBi3} chains composed of face-sharing ScBi6 octahedra. Band calculations indicate that La3ScBi5 is metallic. CSD: 416609.

  4. NMR study of the AF-SC-SC-AF phased transition in a pnictide superconductor LaFeAsO1-xHx

    Science.gov (United States)

    Fujiwara, Naoki; Sakurai, Ryosuke; Iimura, Soushi; Matsuishi, Satoru; Hosono, Hideo; Yamakawa, Youichi; Kontani, Hiroshi

    2014-03-01

    We have performed 75As and 1H NMR measurements in LaFeAsO1xHx, an isomorphic compound of LaFeAsO1xFx. LaFeAsO1xHx is an electron doped system, and O2- can be replaced with H- up to x = 0.5. LaFeAsO1xHx is known for having double superconducting (SC) domes on H doping. Recently, we discovered that a new antiferromagnetic (AF) phase follows the double SC domes on further H doping, forming a symmetric AF-SC-SC-AF phase alignment in the electronic phase diagram Unlike the AF ordering in the lightly H-doped regime, the AF ordering in the highly H-doped regime is attributed to the nesting between electron pockets. In the conference, we will show the data of both NMR spectra and the relaxation rate 1/T1 in the whole doping region. We will discuss the difference of electronic states between the lightly H-doped AF-SC phases and highly H-doped SC-AF phases. This work is supported by a Grant-in-Aid (Grant No. KAKENHI 23340101) from the Ministry of Education, Science, and Culture, Japan.

  5. Crystal structures of the ScCuSe{sub 2} and Sc{sub 3}CuSn{sub 3}Se{sub 11} compounds

    Energy Technology Data Exchange (ETDEWEB)

    Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@lab.univer.lutsk.ua; Shemet, V.Ya. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine); Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)

    2005-05-03

    The crystal structure of the ScCuSe{sub 2} compound was investigated using X-ray powder diffraction (space group P2, a=0.67108(5)nm, b=0.38949(3)nm, c=1.27879(6)nm, {beta}=90.281(6){sup o}, Pearson symbol mP16.08, R{sub I}=0.0839). The structure of ScCuSe{sub 2} represents a distinctive 3axax2c superstructure of Er{sub 2/3}Cu{sub 2}S{sub 2}. The Se atoms are stacked in a close-packed arrangement with layers in the sequence AB. The Sc atoms occupy half of the octahedral sites, the Cu atoms are located in 3/8 of the tetrahedral sites. The crystal structure of the Sc{sub 3}CuSn{sub 3}Se{sub 11} compound (space group Fd3m, a=1.08827(4)nm, Pearson symbol cF52.48, R{sub I}=0.0386) was also determined by means of X-ray powder diffraction. The Se atoms are stacked in a close-packed arrangement with layers in the sequence ABC. The Sc atoms and a statistical mixture M (Sc+Sn) are located in all octahedral sites, the Cu atoms in 1/8 of the tetrahedral sites.

  6. Renormalized molecular levels in a Sc3N@C-80 molecular electronic device

    DEFF Research Database (Denmark)

    Larade, Brian; Taylor, Jeremy Philip; Zheng, Q. R.;

    2001-01-01

    We address several general questions about quantum transport through molecular systems by an ab initio analysis of a scandium-nitrogen doped C-80 metallofullerene device. Charge transfer from the Sc3N is found to drastically change the current-voltage characteristics: the current through the Sc3N...

  7. Supervising M.Sc. Students working in the 100 Gigabit Ethernet field using OPNET Modeler

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Berger, Michael Stübert; Wessing, Henrik

    2010-01-01

    This paper deals with supervision methods for M.Sc. students who are using OPNET Modeler for their thesis work within the field of 100 Gigabit Ethernet. We detail how we use OPNET Modeler in our M.Sc. projects at the Technical University of Denmark. In particular, we discuss on how we teach...

  8. 77 FR 15258 - Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC

    Science.gov (United States)

    2012-03-15

    ... Challenge Kayak Race, Ashley River, Charleston, SC in the Federal Register (76 FR 79571). We received no..., Ashley River, Charleston, SC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... series of moving buffer zones around participant vessels as they transit the Ashley River...

  9. 46 CFR 7.60 - Cape Fear, NC to Sullivans Island, SC.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Fear, NC to Sullivans Island, SC. 7.60 Section 7.60... Atlantic Coast § 7.60 Cape Fear, NC to Sullivans Island, SC. (a) A line drawn from the southernmost... Buoy “2CF”); thence to Oak Island Light. (b) A line drawn from the southernmost extremity of...

  10. Structural and electronic studies of metal carbide clusterfullerene Sc2C2@Cs-C72

    Science.gov (United States)

    Feng, Yongqiang; Wang, Taishan; Wu, Jingyi; Feng, Lai; Xiang, Junfeng; Ma, Yihan; Zhang, Zhuxia; Jiang, Li; Shu, Chunying; Wang, Chunru

    2013-07-01

    We present a metal carbide clusterfullerene Sc2C2@Cs(10528)-C72, whose structure has been baffling for many years. A motional endohedral Sc2C2 cluster, special molecule geometry and electronic structure were found in Sc2C2@Cs(10528)-C72. The paramagnetic Sc2C2@Cs-C72 anion radical was successfully prepared by a chemical reduction method and hyperfine couplings in the ESR spectrum were observed.We present a metal carbide clusterfullerene Sc2C2@Cs(10528)-C72, whose structure has been baffling for many years. A motional endohedral Sc2C2 cluster, special molecule geometry and electronic structure were found in Sc2C2@Cs(10528)-C72. The paramagnetic Sc2C2@Cs-C72 anion radical was successfully prepared by a chemical reduction method and hyperfine couplings in the ESR spectrum were observed. Electronic supplementary information (ESI) available: Experimental details, HPLC chromatogram, and DFT calculations. CCDC 917712. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3nr01739g

  11. DC-SC Photoinjector with Low Emittance at Peking University

    CERN Document Server

    Xiang Rong; Hao, J; Huang, Senlin; Lu Xiang Yang; Quan, Shengwen; Zhang, Baocheng; Zhao, Kui

    2005-01-01

    High average power Free Electron Lasers require the high quality electron beams with the low emittance and the sub-picosecond bunches. The design of DC-SC photoinjector, directly combining a DC photoinjector with an SRF cavity, can produce high average current beam with moderate bunch charge and high duty factor. Because of the DC gun, the emittance increases quickly at the beginning, so a carefully design is needed to control that. In this paper, the simulation of an upgraded design has been done to lower the normalized emittance below 1.5mm·mrad. The photoinjector consists of a DC gap and a 2+1/2-cell SRF cavity, and it is designed to produce 4.2 MeV electron beams at 100pC bunch charge and 81.25MHz repetition rate (8 mA average current).

  12. Mises en scène du racisme italien

    OpenAIRE

    Gallini, Clara

    2007-01-01

    Traduit de l'italien par Giordana Charuty « Chers Italiens vous êtes racistes » Ainsi titre, le 17 mai 1988, Il Corriere della Sera, un des quotidiens italiens au plus fort tirage. Des titres analogues figurent sur les autres journaux. C'est la première fois que le mot racisme apparaît en première page et que les médias braquent leurs projecteurs sur ce phénomène. A partir de ce moment-là, on va assister, en Italie, à une mise en scène inédite d'actes racistes dont la violence se charge de s...

  13. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    Clausen, Johan Christian

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering. Each project description provides a brief overview of the purpose as well as the main activities. Further, a weighting between theoretical analysis, experimental work and computer modelling has been proposed. Usually, this...... page. Furthermore, other ideas for projects may be discussed with a potential supervisor. Many private engineering companies have a homepage on which they state that they would like to collaborate with students on a master project....

  14. Final Report for DOE Grant Number DE-SC0001481

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Edison [Rice University

    2013-12-02

    This report covers research activities, major results and publications supported by DE-SC-000-1481. This project was funded by the DOE OFES-NNSA HEDLP program. It was a joint research program between Rice University and the University of Texas at Austin. The physics of relativistic plasmas was investigated in the context of ultra-intense laser irradiation of high-Z solid targets. Laser experiments using the Texas Petawatt Laser were performed in the summers of 2011, 2012 and 2013. Numerical simulations of laser-plasma interactions were performed using Monte Carlo and Particle-in-Cell codes to design and support these experiments. Astrophysical applications of these results were also investigated.

  15. INTERVIU CU DOAMNA SIMONA CAROBENE, ADMINISTRATORUL SC PROIECT MOZAIC SRL

    OpenAIRE

    Gheorghe Pascaru

    2013-01-01

    Fabrica de mozaic, înregistrată la Oficiul Registrului Comerţului în aprilie 2012 a luat fiinţă în cadrul unui proiect cu finanţare europeană nerambursabilă și are în prezent statutul de unitate protejată autorizată. În cadrul acesteia sunt angajați 10 tineri post instituţionalizați, pentru care integrarea în viaţa socială şi profesională este dificilă. Întreprinderea socială SC Proiect Mozaic SRL este rezultatul întâlnirii dintre sectorul social, non-profit şi sectorul business, deoarece are...

  16. High Current Beam Dynamics in an Ess SC Linac

    CERN Document Server

    Pabst, M; Letchford, A P

    2000-01-01

    Three alternative designs of the European Spallation Source (ESS) high energy linac are described. The most promising ones are either a normalconducting (nc) coupled cavity linac (CCL) up tofinal energy or a change at 407 MeV to only one group of 6 cell superconducting (sc) elliptical cavities. Fully 3d Monte Carlo simulations are presented for both options, optimized for reduced halo formation at the linac end. For the error free matched case, especially the halo formation in the longitudinal plane is more pronounced for the hybrid solution with its superconducting cavities, caused by the unavoidable phase slippage, but still quite well acceptable for loss free ring injection. Simulations however for a 30% mismatched dense core, surrounded in addition by 1.5% halo particles are showing few particles with very large amplitudes even in real space. This case represents halo formation in front to end simulations, caused by current fluctuations, filamented RFQ output distribution and enhanced by accumulated field...

  17. The Successive OH Binding Energies of Sc(OH)n+ for n=1-3

    Science.gov (United States)

    Bauschlicher, Charles W., Jr.; Partridge, Harry; Arnold, James O. (Technical Monitor)

    1996-01-01

    The geometries of Sc(OH)n+, for n = 1-3, have been optimized using density functional theory, in conjunction with the B3LYP hybrid functional. The zero-point energies are computed at the same level of theory. The successive OH bond energies have been computed at the CCSD(T) level for ScOH+ and Sc(OH)2+. The computed result for ScOD+ is in excellent agreement with the recent experiment of Armentrout and co-workers. There is a dramatic drop for the third OH, because Sc+ has only two valence electrons and therefore the bonding changes when the third OH is added. The difference between the B3LYP and CCSD(T) OH binding energies for the first two OH groups is discussed.

  18. Nuclear level densities and gamma-ray strength functions in 44,45Sc

    CERN Document Server

    Larsen, A C; Chankova, R; Lönnroth, T; Messelt, S; Ingebretsen, F; Rekstad, J; Schiller, A; Siem, S; Syed, N U H; Voinov, A

    2007-01-01

    The scandium isotopes 44,45Sc have been studied with the 45Sc(3He,alpha gamma)44Sc and 45Sc(3He,3He' gamma)45Sc reactions, respectively. The nuclear level densities and gamma-ray strength functions have been extracted using the Oslo method. The experimental level densities are compared to calculated level densities obtained from a microscopic model based on BCS quasiparticles within the Nilsson level scheme. This model also gives information about the parity distribution and the number of broken Cooper pairs as a function of excitation energy. The experimental gamma-ray strength functions are compared to theoretical models of the E1, M1, and E2 strength, and to data from (gamma,n) and (gamma,p) experiments. The strength functions show an enhancement at low gamma energies that cannot be explained by the present, standard models.

  19. [Construction and panning of scFv phage display library against recombinant interleukin 4 receptor].

    Science.gov (United States)

    Yang, Guangyong; Guo, Haitao; Liu, Ximing; He, Guangzhi; Tian, Weiyi; Cai, Kun; Wang, Ping; Wang, Wenjia

    2016-06-01

    Objective To construct the recombinant human interleukin 4 receptor (rhIL-4R) single-chain Fv (scFv) antibody library by phage display technique to obtain the anti-IL-4R scFv clones selected from the library. Methods Total RNA was extracted from splenocytes of the BALB/c mice immunized with rhIL-4R. Complementary DNA fragments of variable heavy (VH) and variable light (VL) chains of the antibodies were prepared by reverse transcription PCR and assembled into scFv by splice overlap extension PCR (SOE-PCR). Both scFv and the pCANTAB5E vector were respectively double-digested with restriction endonuclease Sfi I and Not I, connected with T4 ligase, and then transformed into the competent cells E.coli TG1; it was cultured in medium to obtain the phage scFv antibody library; after three rounds of enrichment and panning, the specific antigen scFv with high affinity was selected for the sequencing. Results After three rounds of panning, we obtained a diversity of approximately 2×10(8) anti-rhIL-4R scFv antibody library. Sequencing analysis of one positive clone showed that the anti-rhIL-4R scFv was 741 bp and coded 247 amino acids. The analysis of VBASE2 database indicated that VH and VL gene sequences of anti-rhIL-4R protein all had three complementarity determining regions and four backbone areas.Conclusion The anti-rhIL-4R scFv was obtained from the scFv antibody library. PMID:27371853

  20. Radiolabeling of DOTATOC with the long-lived positron emitter {sup 44}Sc

    Energy Technology Data Exchange (ETDEWEB)

    Pruszynski, Marek; Majkowska-Pilip, Agnieszka [Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warszawa (Poland); Loktionova, Natalia S.; Eppard, Elisabeth [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Roesch, Frank, E-mail: frank.roesch@uni-mainz.de [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)

    2012-06-15

    The positron-emitting radionuclide {sup 44}Sc with a half-life of 3.97 h and a {beta}{sup +} branching of 94.3% is of potential interest for clinical PET. As so far it is available from a {sup 44}Ti/{sup 44}Sc generator in Mainz, where long-lived {sup 44}Ti decays to no-carrier-added (nca) {sup 44}Sc. The {sup 44}Sc is a trivalent metal cation and should be suitable for complexation with many well established bifunctional chelators conjugated to peptides or other molecular targeting vectors. Thus, the aim of this work was to investigate the potential of {sup 44}Sc for labeling of DOTA-conjugated peptides. DOTA-D-Phe{sup 1}-Tyr{sup 3}-octreotide (DOTATOC) was used as a model molecule to study and optimize labeling procedure. Reaction parameters such as buffer conditions, concentration of peptide, pH range, reaction temperature and time were optimized. Addition of 21 nmol of DOTATOC to {sup 44}Sc in ammonium acetate buffer pH 4.0 provided labeling yields >98% within 25 min of heating in an oil-bath at 95 Degree-Sign C. This time can be reduced to 3 min only by applying microwave supported heating. {sup 44}Sc-DOTATOC was found to be stable in 0.9% NaCl, PBS pH 7.4, fetal calf and human serums, and also in the presence of competing metal cations (Fe{sup 3+}, Ca{sup 2+}, Cu{sup 2+}, Mg{sup 2+}), as well as other ligand competitors, like EDTA and DTPA, even after almost 25 h incubation at 37 Degree-Sign C. Present study shows that nca {sup 44}Sc forms stable complexes with the macrocyclic ligand DOTA and that {sup 44}Sc-DOTATOC and analog targeting vectors may be synthesized for further preclinical and clinical investigations. - Highlights: Black-Right-Pointing-Pointer Labeling of somatostatin analouges with positron emitter {sup 44}Sc was tested. Black-Right-Pointing-Pointer DOTATOC was labeled with {sup 44}Sc isotope. Black-Right-Pointing-Pointer Optimal conditions for {sup 44}Sc-DOTATOC synthesis were found. Black-Right-Pointing-Pointer Stability of {sup 44}Sc

  1. First-principles study of elastic and electronic properties of MgZn2 and ScZn2 phases in Mg-Sc-Zn alloy

    International Nuclear Information System (INIS)

    Research highlights: MgZn2 and ScZn2 are the important strengthening phases, and have recently led to a renewed interest in the research and development of Mg-based alloys, so theoretical investigations on the elastic properties of MgZn2 and ScZn2 are necessary and urgent. The present paper investigated the elastic and electronic properties of MgZn2 and ScZn2 phases in Mg-Sc-Zn alloy by means of first-principles calculation. The elastic constants and other mechanical parameters such as bulk modulus B, shear modulus G, Young's modulus E and Poisson's ratio ν of polycrystalline aggregates were studied, and the ductility and plasticity were further discussed. Furthermore, the electronic structure was investigated for understanding the underlying mechanism of the structural stability and elastic properties. These results would be valuable for the further optimization and design of Mg-rare earth alloys with excellent mechanical properties. - Abstract: The structural, electronic and elastic properties of typical hexagonal-close-packed MgZn2 and ScZn2 phases in Mg-Sc-Zn alloy were investigated by means of first-principles calculations within the framework of density functional theory (DFT). The calculated lattice constants were in good agreement with the experimental values. The obtained cohesive energy and formation enthalpy of both phases are negative, showing their structural stability from energetic point of view. The five independent elastic constants were calculated, and then the bulk modulus B, shear modulus G, Young's modulus E and Poisson's ratio ν of polycrystalline aggregates were derived. The ductility and plasticity of the MgZn2 and ScZn2 phases were further discussed. The elastic anisotropy of the two phases was also analyzed. Finally, the electronic density of states (DOS) and charge density distribution were also calculated to reveal the underlying mechanism of structural stability and mechanical properties.

  2. Modeling of an anode-supported Ni-YSZ vertical stroke Ni-ScSZ vertical stroke ScSZ vertical stroke LSM-ScSZ multiple layers SOFC cell. Part I. Experiments, model development and validation

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Yixiang; Cai, Ningsheng; Li, Chen; Bao, Cheng [Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084 (China); Croiset, Eric [Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1 (Canada); Qian, Jiqin; Hu, Qiang; Wang, Shaorong [Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS), 1295 Dingxi Road, Shanghai 200050 (China)

    2007-10-11

    This paper is the first part of a two-part paper and presents the development, calibration and validation of a two-dimensional isothermal mechanistic model of a composite yttria/scandia-stabilized zirconia anode-supported multiple layers solid oxide fuel cell (Ni-YSZ vertical stroke Ni-ScSZ vertical stroke ScSZ vertical stroke LSM-ScSZ). This model was developed to describe the intricate interdependency among the ionic conduction, electronic conduction, multi-component species transport, electrochemical reaction processes and electrode microstructure for intermediate temperatures operation between 750 and 850 C. This model takes into account the fact that the electrochemical reactions take place throughout the electrodes and not only at the electrolyte/electrode boundaries. The model was calibrated using experimental polarization curves and then validated by comparing each cell component polarizations (anodic, cathodic and electrolyte) determined from the simulation and from specific experiments using a symmetric cell and EIS measurements. (author)

  3. Cyclotron production of high purity 44m,44Sc with deuterons from 44CaCO3 targets

    International Nuclear Information System (INIS)

    Introduction: Due to its longer half-life, 44Sc (T1/2 = 3.97 h) as a positron emitter can be an interesting alternative to 68Ga (T1/2 = 67.71 min). It has been already proposed as a PET radionuclide for scouting bone disease and is already available as a 44Ti/44Sc generator. 44Sc has an isomeric state, 44mSc (T1/2 = 58.6 h), which can be co-produced with 44Sc and that has been proved to be considered as an in-vivo PET generator 44mSc/44Sc. This work presents the production route of 44mSc/44Sc generator from 44Ca(d,2n), its extraction/purification process and the evaluation of its performances. Methods: Irradiation was performed in a low activity target station using a deuteron beam of 16 MeV, which favors the number of 44mSc atoms produced simultaneously to 44Sc. Typical irradiation conditions were 60 min at 0.2 μA producing 44 MBq of 44Sc with a 44Sc/44mSc activity ratio of 50 at end of irradiation. Separations of the radionuclides were performed by means of cation exchange chromatography using a DGA® resin (Triskem). Then, the developed process was applied with bigger targets, and could be used for preclinical studies. Results: The extraction/purification process leads to a radionucleidic purity higher than 99.99% (43Sc, 46Sc, 48Sc < DL). 44mSc/44Sc labeling towards DOTA moiety was performed in order to get an evaluation of the specific activities that could be reached with regard to all metallic impurities from the resulting source. Reaction parameters of radiolabeling were optimized, reaching yields over 95%, and leading to a specific activity of about 10–20 MBq/nmol for DOTA. A recycling process for the enriched 44Ca target was developed and optimized. Conclusion: The quality of the final batch with regard to radionucleidic purity, specific activity and metal impurities allowed a right away use for further radiopharmaceutical evaluation. This radionucleidic pair of 44mSc/44Sc offers a quite interesting PET radionuclide for being further evaluated as an in

  4. Technical Training: CERN Technical Training 2004 - New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 31.8.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 31.8.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 7.9.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and s...

  5. CERN Technical Training 2004: New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 22.10.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 22.10.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and...

  6. CERN Technical Training 2004: New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 31.8.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 31.8.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 7.9.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she...

  7. Differential dynamics of splicing factor SC35 during the cell cycle

    Indian Academy of Sciences (India)

    Kaushlendra Tripathi; Veena K Parnaik

    2008-09-01

    Pre-mRNA splicing factors are enriched in nuclear domains termed interchromatin granule clusters or nuclear speckles. During mitosis, nuclear speckles are disassembled by metaphase and reassembled in telophase in structures termed mitotic interchromatin granules (MIGs). We analysed the dynamics of the splicing factor SC35 in interphase and mitotic cells. In HeLa cells expressing green fluorescent protein (GFP)-SC35, this was localized in speckles during interphase and dispersed in metaphase. In telophase, GFP-SC35 was highly enriched within telophase nuclei and also detected in MIGs. Fluorescence recovery after photobleaching (FRAP) experiments revealed that the mobility of GFP-SC35 was distinct in different mitotic compartments. Interestingly, the mobility of GFP-SC35 was 3-fold higher in the cytoplasm of metaphase cells compared with interphase speckles, the nucleoplasm or MIGs. Treatment of cells with inhibitors of cyclin-dependent kinases (cdks) caused changes in the organization of nuclear compartments such as nuclear speckles and nucleoli, with corresponding changes in the mobility of GFP-SC35 and GFP-fibrillarin. Our results suggest that the dynamics of SC35 are significantly influenced by the organization of the compartment in which it is localized during the cell cycle.

  8. EngenuitySC Commercialization and Entrepreneurial Training Project

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Meghan; Hutton, Katherine R

    2012-12-31

    A team led by EngenuitySC has performed education and outreach on development of advanced energy markets that will enable wider use of clean energy technologies. This report details the efforts that have made significant advances to improve the market place through education, outreach, and increased communications between industry members. The project resulted in two self-funded industry clusters known as the Fuel Cell Collaborative and NuHub. This project has focused on building and strengthening the leading clean energy clusters in South Carolina: nuclear energy and fuel cell technologies. For the nuclear industry, a new cluster was developed that is now known as NuHub. This cluster has already engaged over 25 nuclear industry leaders or suppliers, four public sector partners, six community economic development foundations, and nearly ten academic partners in a 175 mile radius between Augusta, Georgia and Charlotte, North Carolina. Our outreach has touched over 2,000 stakeholders through the website alone, not including the public audiences and members of the business community reached through news stories and releases that were distributed to over 620 print and online publications. NuHub has established a formal leadership structure, developed subcommittees to focus on industry issues, instituted educational programs for the workforce, and created an industry funding structure that will sustain the industry cluster and mission. NuHub has participated in a wide-variety of community building and outreach activities since its formation under this grant. In the two years since its creation in 2010, we have initiated efforts focused in four main areas that correlate with the four NuHub subcommittees including: innovation, workforce development, industry engagement, and marketing and communications. NuHub successfully raised over $160,000 in both public and private funding, which has supported work to grow the cluster and engage partners including NuScale, Fluor, and

  9. Synergistic capture of Clostridium botulinum Type A neurotoxin by scFv antibodies to novel epitopes

    Energy Technology Data Exchange (ETDEWEB)

    Gray, Sean A.; Barr, John R.; Kalb, Suzanne R.; Marks, James D.; Baird, Cheryl L.; Cangelosi, Gerard A.; Miller, Keith D.; Feldhaus, Michael J.

    2011-10-01

    A non-immune library of human single chain fragment variable (scFv) antibodies displayed on Saccharomyces cerevisiae was screened for binding to the Clostridium botulinum neurotoxin serotype A binding domain [BoNT/A (Hc)] with the goal of identifying scFv to novel epitopes. To do this, an antibody-mediated labeling strategy was used in which antigen-binding yeast clones were selected after labeling with previously characterized monoclonal antibodies (MAbs) specific to the Hc. Twenty unique scFv clones were isolated that bound Hc. Of these, three also bound to full-length BoNT/A toxin complex with affinities ranging from 5 nM to 170 nM. Epitope binning showed that the three unique clones recognized at least two epitopes that were distinct from one another and from the detection MAbs. After production in E. coli, the scFv were coupled to magnetic particles and tested for their ability to capture BoNT/A holotoxin using an Endopep-MS assay. In this assay, toxin captured by scFv coated magnetic particles was detected by incubation of the complex with a peptide containing a BoNT/A-specific cleavage sequence. Mass spectrometry was used to detect the ratio of intact peptide to cleavage products as evidence for toxin capture. When tested individually, each of the scFv showed a weak positive Endopep-MS result. However, when the particles were coated with all three scFv simultaneously, they exhibited significantly higher Endopep-MS activity, consistent with synergistic binding. These results demonstrate novel approaches toward the isolation and characterization of scFv antibodies specific to unlabeled antigen. They also provide evidence that distinct scFv antibodies can work synergistically to increase the efficiency of antigen capture onto a solid support.

  10. SC-41930: An inhibitor of leukotriene B4-stimulated human neutrophil functions

    International Nuclear Information System (INIS)

    SC-41930 was evaluated for effects on human neutrophil chemotaxis and degranulation. At concentrations up to 100 microM, SC-41930 alone exhibited no effect on neutrophil migration, but dose-dependently inhibited neutrophil chemotaxis induced by leukotriene B4 (LTB4) in a modified Boyden chamber. Concentrations of SC-41930 from 0.3 microM to 3 microM competitively inhibited LTB4-induced chemotaxis with a pA2 value of 6.35. While inactive at 10 microM against C5a-induced chemotaxis, SC-41930 inhibited N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, with 10 times less potency than against LTB4-induced chemotaxis. SC-41930 inhibited [3H]LTB4 and [3H]fMLP binding to their receptor sites on human neutrophils with KD values of 0.2 microM and 2 microM, respectively. SC-41930 also inhibited neutrophil chemotaxis induced by 20-OH LTB or 12(R)-HETE. At concentrations up to 10 microM, SC-41930 alone did not cause neutrophil degranulation, but inhibited LTB4-induced degranulation in a noncompetitive manner. SC-41930 also inhibited fMLP- or C5a-induced degranulation, but was about 8 and 10 times less effective for fMLP and C5a, respectively. The results indicate that SC-41930 is a human neutrophil LTB4 receptor antagonist with greater specificity for LTB4 than for fMLP or C5a receptors

  11. Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription

    OpenAIRE

    Schubot, Florian D; Chen, Chun-Jung; Rose, John P.; Dailey, Tamara A.; Dailey, Harry A.; Wang, Bi-Cheng

    2001-01-01

    Although it is commonly accepted that binding of mitochondrial transcription factor sc-mtTFB to the mitochondrial RNA polymerase is required for specific transcription initiation in Saccharomyces cerevisiae, its precise role has remained undefined. In the present work, the crystal structure of sc-mtTFB has been determined to 2.6 Å resolution. The protein consists of two domains, an N-terminal α/β-domain and a smaller domain made up of four α-helices. Contrary to previous predictions, sc-mtTFB...

  12. Current Lead System of the SuperKEKB Final Focus SC Magnet Cryostats

    Science.gov (United States)

    Zong, Z. G.; Ohuchi, N.; Tsuchiya, K.; Arimoto, Y.; Higashi, N.; Yamaoka, H.; Kondou, Y.; Kawai, M.

    To energize the SuperKEKB final focus superconducting (SC) magnets, 110 current leads in total will be equipped in the two service cryostats. For the SC quadrupoles and solenoids, 22 leads are the conventional vapor cooled type and the others for the SC correction coils employ an HTS section at the cold ends. The qualification program on the leads is being carried out at KEK as the cryogenic acceptance test prior to installation. This paper presents the thermal and electrical results of the cryogenic tests.

  13. Synthesis, Structure and Properties of Scandium Dysprosium Antimonide, ScDySb

    OpenAIRE

    Nuss, Jürgen; Wedig, Ulrich; Jansen, Martin

    2010-01-01

    Abstract Scandium dysprosium antimonide ScDySb was synthesized from scandium metal and DySb in an all-solid state reaction at 1770 K. According to X-ray analysis of the crystal structure (P4/nmm, Z = 4, a = 430.78(1) pm, c = 816.43(4) pm, R1 = 0.0238, wR(all) = 0.0688, 268 independent reflections), ScDySb adopts the anti-PbFCl type of structure, but with pronounced deviations in structural details, which are related to specific bonding interactions between the atoms involved. ScDyS...

  14. Sc-Si normal incidence mirrors for a VUV interval of 35-50 nm

    CERN Document Server

    Uspenskii, Y A; Vinogradov, A V; Fedorenko, A I; Kondratenko, V V; Pershin, Y P; Zubarev, E N; Mrowka, S; Schäfers, F

    2000-01-01

    The Sc/Si multilayers are suggested as high-reflectivity coatings for a VUV interval of 35-50 nm. Fabricated mirrors show the normal incidence reflectivity of 30-50% which is high enough to effectively manipulate the beams of synchrotron radiation and compact discharge and laser-driven X-ray lasers. The obtained values are not, however, limiting for the Sc/Si coatings. Theoretical estimations as well as electron microscopy studies of Sc-Si interfaces indicate a large potential for further raising the reflectivity.

  15. Theoretical study on the possibility of bipolar doping of ScN

    OpenAIRE

    Soto, G.; Moreno-Armenta, M. G.; Reyes-Serrato, A.

    2008-01-01

    Scandium nitride (ScN) is a semiconducting transition metal nitride for which there are not identified dopants. We present local density functional calculations, in supercell approach, for ScN doped with O and C in N-sites and Ca and Ti in Sc-sites. Small additions of these atoms have the effect of shifting the Fermi level within the electronic band structure. O and Ti bring occupied states in bottom of conduction band, while C and Ca produces holes in top of valence band. Based on the theory...

  16. Far infrared properties of the rare-earth scandate DyScO3.

    Science.gov (United States)

    Baldassarre, L; Perucchi, A; Lupi, S; Dore, P

    2010-09-01

    We present reflectance measurements in the infrared region on a single crystal the rare-earth scandate DyScO(3). Measurements performed between room temperature and 10 K allow us to determine the frequency of the infrared-active phonons, never investigated experimentally, and to get information on their temperature dependence. A comparison with the phonon peak frequency resulting from ab initio computations is also provided. We finally report detailed data on the frequency dependence of the complex refractive index of DyScO(3) in the terahertz region, which is important in the analysis of terahertz measurements on thin films deposited on DyScO(3). PMID:21403288

  17. Far infrared properties of the rare-earth scandate DyScO3

    International Nuclear Information System (INIS)

    We present reflectance measurements in the infrared region on a single crystal the rare-earth scandate DyScO3. Measurements performed between room temperature and 10 K allow us to determine the frequency of the infrared-active phonons, never investigated experimentally, and to get information on their temperature dependence. A comparison with the phonon peak frequency resulting from ab initio computations is also provided. We finally report detailed data on the frequency dependence of the complex refractive index of DyScO3 in the terahertz region, which is important in the analysis of terahertz measurements on thin films deposited on DyScO3.

  18. Assembly of a supercrystal (SC) of the CMS endcap electromagnetic calorimeter

    CERN Multimedia

    J. Williams et al., RAL

    2004-01-01

    The first three pictures show the insertion of the first three rows of crystals into the supercrystal SC03 on Jan. 2004 and the completion of the SC endstops. Fig. 4 shows a complete supercrystal and Fig. 5 its components (alveolar, interface plate, housing, optical fibre, insert, crystal and VPT, endstop). A set of 25 inserts is shown in Fig. 6, while Fig. 7 shows housing, interface plates and inserts. Finally, a SC rear view showing the Vacum Phototriode (VPT) wires through the inserts can be seen in Fig. 8. Fig. 9 and 10 show two supercrystals under test on Dee F and R, respectively.

  19. Simple Cubic Carbon Phase C21-sc: A Promising Superhard Carbon Conductor

    OpenAIRE

    He, Chaoyu; MENG, LIJUN; Tang, Chao; Zhong, Jianxin

    2014-01-01

    Traditionally, all superhard carbon phases including diamond are electric insulators and all conductive carbon phases including graphite are mechanically soft. Based on first-principles calculation results, we report a superhard but conductive carbon phase C21-sc which can be obtained through increasing the sp3 bonds in the previously proposed soft and conductive phase C20-sc (Phys. Rev. B 74, 172101 2006). We also show that further increase of sp3 bonds in C21-sc results in a superhard and i...

  20. Lanthanide-doped NaScF4 nanoprobes: crystal structure, optical spectroscopy and biodetection

    Science.gov (United States)

    Ai, Yu; Tu, Datao; Zheng, Wei; Liu, Yongsheng; Kong, Jintao; Hu, Ping; Chen, Zhuo; Huang, Mingdong; Chen, Xueyuan

    2013-06-01

    Trivalent lanthanide ions (Ln3+)-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc3+ with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu3+ at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln3+ NPs were synthesized via a facile thermal decomposition method. The biotinylated NaScF4:Er3+/Yb3+ NPs were demonstrated for their applications as a heterogeneous UC luminescence bioprobe to detect avidin with a detection limit of 180 pM. After bioconjugation with amino-terminal fragment (ATF) of urokinase plasminogen activator (uPA), NaScF4:Ln3+ NPs also exhibited specific recognition of cancer cells overexpressed with uPA receptor (uPAR, an important marker of tumor biology and metastasis), showing great potentials in tumor-targeted bioimaging.Trivalent lanthanide ions (Ln3+)-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc3+ with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu3+ at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln3+ NPs were synthesized via a facile thermal

  1. Conceptual design of SC magnet system for ITER, (2)

    International Nuclear Information System (INIS)

    The International Thermonuclear Experimental Reactor (ITER) is an experimental tokamak machine testing the basic plasma performance and technologies required for future tokamak reactor. The design proposals for the Superconducting (SC) Magnet System from Japan were summarized by the Fusion Experimental Reactor (FER) Design Team and the Superconducting Magnet Laboratory of the Japan Atomic Energy Research Institute (JAERI). This report is one of the series reports on 'Conceptual design of superconducting magnet system for ITER', and describes the major results of the stress analysis regarding the Toroidal Field (TF) coil, the Center Solenoid (CS) coil and the Equilibrium Field (EF) coil and their support structures. Among the design issues, the mechanical design of the coil system was one of the most critical items, not only because of the huge electromagnetic loads due to large size and high magnetic field, but also because of the demand of high reliability under neutron irradiation. In order to satisfy both the coil performance and the mechanical reliability, different types of conductors were employed for each coils. The mechanical behaviors and the safety margin of each coil were analyzed by using finite element method (FEM) of MSC/NASTRAN. The procedure to obtain the equivalent winding stiffness employed for the each FEM analysis is also described in this report. The details on the coil specifications, conductor design and mechanical design for each coils are described in other report of the series reports. (J.P.N.)

  2. Transition energy and oscillator strength of Sc18+ion

    Institute of Scientific and Technical Information of China (English)

    Wang Zhi-Wen; Yang Di; Hu Mu-Hong; Han Qiu-Ju; Li Jin-Ying

    2005-01-01

    The transition energies and the dipole oscillator strengths for the 1s22s-1s2np (2 ≤ n ≤ 9) and 1s22p-1s2nd (3≤n ≤ 9) of lithium-like Sc18+ ion are calculated by using the full core plus correlation method. The fine structure splittings of 1s2np and 1s2nd (n ≤ 9) states are determined from the expectation values of spin-orbit and spin-otherorbit interaction operators. The quantum defects of these series, as function of principal quantum number n, are obtained. The agreement between the f-values obtained from three alternative formulae is excellent. Comparisons of our results with experimental data available in the literature are carried out. Combining the single-channel quantum defect theory with the discrete oscillator strengths obtained in this work, this paper obtains the behaviour of discrete oscillator strengths and oscillator strength densities corresponding to the bound-free transitions adjacent to ionization threshold.

  3. Low-dimensional ScO2 with tunable electronic and magnetic properties: first-principles studies.

    Science.gov (United States)

    Zhang, Hui; Tong, Chuan-Jia; Wu, Jian; Yin, Wen-Jin; Zhang, Yan-Ning

    2016-01-13

    Transition metal dichalcogenides (TMDs) have attracted extensive attention due to their appealing properties for device applications. In this work, we explored the structure stability, electronic structure and magnetism of low-dimensional scandium dioxides, ScO2, by using the first-principles calculations. The results demonstrate that bulk ScO2, monolayers and nanoribbons (NRs) are thermodynamically stable, implying a high possibility of fabricating ScO2 nanocrystals in experiments. Despite the metallic characteristics of bulk ScO2, low-dimensional ScO2 possesses various electronic behaviors that can be further modulated by crystal structure and dimensionality. The results also show that the ground states of ScO2 monolayers and NRs are ferromagnetic (FM) with about 1 μ B per ScO2 formula. Our studies expand a new realm in low-dimensional TMDs, with tunable electronic and magnetic properties. PMID:26571138

  4. Formation Processes of Nanocomposite Strengthening Particles in Rapidly Quenched Al-Sc-Zr Alloys

    Directory of Open Access Journals (Sweden)

    A.V. Kotko

    2012-03-01

    Full Text Available Decomposition processes of supersaturated solid solution of aluminium alloys alloyed with Sc and Zr have been studied in the work. The binary hypereutectic Al-Sc alloys, hyperperitectic Al-Zr alloys and ternary Al-Sc-Zr alloys were chosen. Alloys were obtained by the melt-spinning. Melts were quenched from temperatures of Т = 1000 C and Т = 1400 ºC. The study of the structure of rapidly solidifyed binary Al alloys alloyed with Sc and Zr showed that the crystallization of anomalously supersaturated solid solution (Tquen. = 1400 ºC or the crystallization with the formation of "fan" structure (Tquen. = 1000 ºC are possible depending on the quenching temperature of the melt. The decomposition of anomalously supersaturated solid solution is continuous, with the precipitation of nano-sized spherical Al3X (X-Sc, Zr particles of L12-ordered phase which is isomorphous to matrix. It was found that the loss of thermal stability of Al-Sc alloys is due to the loss of coherence of the strengthening Al3Sc phase. In Al-Zr alloys the loss of strength is due to the formation of a stable tetragonal DO23-ordered A13Zr phase. After co-alloying of Al by Sc and Zr a bimodal grained structure was observed for the hypereutectic ternary alloy (Tquen. = 400ºC. Nano-sized grains of 50-60 nm were present on the boundaries of 1-2 µm large-sized grains. TEM shows the formation of nanocomposite Al3Zr/Al3Sc particles. The formation of Al3Zr shell changes the nature of the interfacial fit of the particle with the matrix and slows down the decomposition during the coalescence. Ternary Al-Sc-Zr alloys have significantly higher thermal stability during aging as compared to binary Al-Sc and Al-Zr alloys. Decomposition processes of supersaturated solid solution of aluminium alloys alloyed with Sc and Zr have been studied in the work. The binary hypereutectic Al-Sc alloys, hyperperitectic Al-Zr alloys and ternary Al-Sc-Zr alloys were chosen. Alloys were

  5. The creep behaviour of single-crystal turbine blade alloys basing on nickel SC 16 with [011] orientation; Das Kriechverhalten der einkristallinen Nickelbasisturbinenschaufellegierung SC 16 MIT [011]-Orientierung

    Energy Technology Data Exchange (ETDEWEB)

    Klingelhoeffer, H.; Chrzanowski, U.; Kraemer, E.; Frenz, H.; Ziebs, J. [Bundesanstalt fuer Materialforschung und -pruefung, Berlin (Germany)

    1997-12-31

    This paper describes the creep behaviour of single-crystal turbine blade alloys basing on nickel SC 16 compared to the material IN 738 LC while submitted to creep strain. The creep properties of samples with [011] and [001]-orientation are compared with each other. (orig./MM) [Deutsch] In der vorliegenden Arbeit wird das Kriechverhalten der einkristallinen Nickelbasissuperlegierung SC 16 im Vergleich zum Werkstoff IN 738 LC unter Kriechbeanspruchung dargestellt. Dabei werden die Kriecheigenschaften von Proben mit [011]- und [001]-Orientierung gegenuebergestellt. (orig./MM)

  6. SC-600型双气压呼吸机二次设计开发%Second Design and Development of SC-600 Type Double Pressure Breathing Machine

    Institute of Scientific and Technical Information of China (English)

    陈斌

    2016-01-01

    In view of the large noise and high failure rate of the valve of the SC-600 type double pressure breathing machine during clinical using, the paper describes the main improvement methods of the second design and development of this type of machine.%该文针对SC-600型双气压呼吸机在临床使用过程中发现的噪音过大、呼吸比例阀故障率高等质量问题,阐述了该设备的二次设计开发的主要改进方法。

  7. Damping values for seismic design of nuclear power plant SC structures

    International Nuclear Information System (INIS)

    The paper describes the research work of experimental testing method, analysis of test results and proposed damping values for seismic design of nuclear power plant SC (steel-plate concrete) structures

  8. Promising electron mobility and high thermal conductivity in Sc2CT2 (T = F, OH) MXenes

    Science.gov (United States)

    Zha, Xian-Hu; Zhou, Jie; Zhou, Yuhong; Huang, Qing; He, Jian; Francisco, Joseph S.; Luo, Kan; Du, Shiyu

    2016-03-01

    MXenes, the new 2D transition metal carbides and nitrides, have recently attracted extensive attention due to their diverse applications and excellent performances. However, the thermal and electrical properties of most MXene materials are yet to be studied. In this work, we investigate the electrical and thermal properties of semiconducting Sc2CT2 (T = F, OH) MXenes using first-principles calculations. Both of the Sc2CT2 (T = F, OH) MXenes are determined to show excellent carrier mobilities. The electron mobility in the Sc2CF2 MXene is found to be strongly anisotropic at room temperature, with values of 5.03 × 103 and 1.07 × 103 cm2 V-1 s-1 in the zigzag and armchair directions, respectively. The predicted electron mobility in the zigzag direction of the Sc2CF2 is nearly four-fold that in the armchair direction of the promising semiconductor phosphorene. In contrast to Sc2CF2, Sc2C(OH)2 presents approximately isotropic electron mobility. The values at room temperature in the zigzag and armchair directions are calculated as 2.06 × 103 cm2 V-1 s-1 and 2.19 × 103 cm2 V-1 s-1, respectively. In regard to the thermal properties, the thermal conductivities of the Sc2CT2 (T = F, OH) MXenes have been determined. The predicted values are higher than those of most metals and semiconducting low-dimensional materials, such as monolayer MoS2 and phosphorene. In particular, the room-temperature thermal conductivity along the Sc2CF2 armchair direction has been determined to be as high as 472 W m-1 K-1 based on a flake length of 5 μm, which is even higher than that of the best traditional conductor silver. The corresponding value in the zigzag direction of Sc2CF2 is calculated to be 178 W m-1 K-1. The thermal conductivity in Sc2C(OH)2 is less anisotropic and lower compared to that in Sc2CF2. The room-temperature value in the armchair (zigzag) direction is determined to be 173 W m-1 K-1 (107 W m-1 K-1). Based on their excellent electron mobilities and high thermal

  9. DiSC aitab käitumist parandada / Ain Kivesti

    Index Scriptorium Estoniae

    Kivesti, Ain

    2008-01-01

    DiSC testi abil on võimalik saada ülevaade personaalsetest käitumishoiakutest ning vastavalt olukorrale on võimalik harjumuspärast reageerimisstiili radikaalselt muuta. Kommenteerivad Jorma Sarv ja Paavo Pilv

  10. Refining the thermodynamic functions of scandium triflouride ScF3 in the condensed state

    Science.gov (United States)

    Aristova, N. M.; Belov, G. V.

    2016-03-01

    Refined thermodynamic functions (entropy, enthalpy increments, and reduced Gibbs energy) of scandium trifluoride ScF3 in the crystalline and liquid states in the temperature range 5-2500 K are presented.

  11. Expression of recombinant human anti-TNF-α scFv-Fc in Arabidopsis thaliana seeds.

    Science.gov (United States)

    Yao, N; Ai, L; Dong, Y Y; Liu, X M; Wang, D Z; Wang, N; Li, X W; Wang, F W; Li, Xk; Li, H Y; Jiang, C

    2016-01-01

    Recombinant human anti-tumor necrosis factor (TNF)-α scFv-Fc was expressed in TKO mutant Arabidopsis thaliana seeds using plant-specific codons. Immunoblotting using a human IgG1 antibody detected the expression of anti-TNF-α proteins in plants. Results from qRT-PCR analysis demonstrated that the time of harvest significantly affected the protein yield and quality. Our results indicate that the Phaseolus vulgaris β-phaseolin promoter directed anti-TNF-α scFv-Fc expression in A. thaliana seeds, with a maximum yield obtained at 20-days of development. Although the yield of anti-TNF-α scFv-Fc protein was not very high, accumulation of recombinant proteins in seeds is an attractive and simple method that can be used to purify biologically active anti-TNF-α scFv-Fc. PMID:27420937

  12. Al-Cu based welding wire with minor Sc-Zr alloying and its application

    Institute of Scientific and Technical Information of China (English)

    尹志民; 郭飞跃; 潘青林; 宋练鹏

    2003-01-01

    A kind of Al-Cu-(Sc, Zr, Mn, Ti, V, B) welding wire was developed by adding minor Sc, Zr, Mn, V, B, and was used for welding 2195 aluminum alloy plate with a thickness of 2 mm. Mechanical properties and microstructure of welding wire and welding joint were studied. The results show that strength coefficient of the welding joint is 0.70 and the weakest area lies in the softened zone of HAZ. It is indicated that this welding wire adding minor Sc, Zr, Mn, V, B is an ideal welding wire for 2195 Al-Li alloy plate. The high strength of the weld comes from grain-refining strengthening and precipitation strengthening of Al2Cu, Al3Sc and Al3Zr.

  13. Electrochemical Characterization of Ni/ScYSZ Electrodes as SOFC Anodes

    DEFF Research Database (Denmark)

    Ramos, Tania; Søgaard, Martin; Mogensen, Mogens Bjerg

    2014-01-01

    Investigations of Ni/ScYSZ cermets were performed by electrochemical impedance spectroscopy (EIS) using different symmetric designs: electrolyte supported (ESC) and anode supported (ASC) cells. The obtained spectra were analyzed using distribution of relaxation times (DRT), and complex non...

  14. Correlative characterization of primary Al3(Sc,Zr) phase in an Al–Zn–Mg based alloy

    International Nuclear Information System (INIS)

    Three-dimensional electron backscatter diffraction, focused ion beam, transmission electron microscopy and energy filtered transmission electron microscopy were employed to investigate the structural information of primary Al3(Sc,Zr) phase, i.e. size, shape, element distribution and orientation relationship with the α-Al matrix. It was found that (i) most primary Al3(Sc,Zr) phases have a cubic three-dimensional morphology, with a size of about 6–10 μm, (ii) most primary Al3(Sc,Zr) phases are located within the α-Al matrix, and exhibit a cube to cube orientation relationship with the α-Al matrix, and (iii) a layer by layer growth was observed within primary Al3(Sc,Zr) phases. Al, Cu, Si and Fe are enriched in the α-Al matrix between the layers of cellular eutectic Al3(Sc,Zr) phase, while Sc, Ti and Zr are enriched in small Al3(Sc,Zr) phases. A peritectic reaction and subsequent eutectic reaction between Al3Sc and Al was proposed to interpret the observed layer by layer growth. This paper demonstrates that the presence of impurities (Fe, Si, Cu, Ti) in the diffusion field surrounding the growing Al3(Sc,Zr) particle enhances the heterogeneous nucleation of Al3(Sc,Zr) phases. - Highlights: • Most fine cubic primary Al3(Sc,Zr) phases were observed within the α-Al matrix. • A layer by layer growth within primary Al3(Sc,Zr) phase was observed. • A peritectic and subsequent eutectic reaction between Al3Sc and Al was proposed. • Impurities in diffusion fields enhance heterogeneous nucleation of Al3(Sc,Zr)

  15. Local Impact Simulation of SC Wall Structures using Aircraft Engine Projectile

    International Nuclear Information System (INIS)

    SC wall structure developed for nuclear power plant buildings consists of plain concrete and two steel plates on both surface of the concrete, while RC structure consists of re bar and concrete. SC structure has higher scabbing resistance than RC structure due to the action of steel plate on the rear side of impact. Therefore SC structure is known as more effective structure from the viewpoint of aircraft crash than RC structure. However, most of the recent researches and experiments about local impact damage deal with RC structures, and the effect of re bar and steel plate is not considered reasonably. Although Walter et al. and Make-work et al. suggested a formula for evaluating perforation depth of steel plate covered RC walls, most of the previous researches about SC structure are focused on perforation and scabbing due to the impact of hard projectile, rather than soft projectile such as an aircraft. In this research a soft projectile, i. e. aircraft engine, is utilized for impact simulation of RC and SC walls. To evaluate local damage of SC wall structures, parametric study with the variables of wall thickness and steel ratio of the cover plate is performed, and the results are compared with those of RC structures. Since scabbing was prevented by the steel plates, penetration mode of damage was observed in SC walls while scabbing damage was occurred in RC walls. It is confirmed that the rear steel plate not only contains concrete debris, but also reduces the internal damage of the concrete walls. Penetration depth of SC walls did not largely vary due to the increasing steel ratio, and similar results to RC walls were observed when the wall thickness is larger than a certain value since the impact resistance of SC wall is mainly governed by the thickness of concrete part. Therefore, it is expected that similar level of impact resistance to RC structure can be produced with the minimum thickness of steel plates of SC structure. According to these results, SC

  16. Effects of geometric and material parameters on failure modes of SC elements

    OpenAIRE

    Lohani, Vishesh

    2016-01-01

    A steel-concrete-steel composite (SC) element resembles double skin sandwich composite structure in which the concrete core is in-filled between steel skins. Mechanical shear connectors connect the skins and they are embedded in concrete. These connectors transfer shear forces and have an important role in performance of composite element. SC element is prone to different failure modes such as flexural failure, de-bonding between steel plate and concrete, and shear failure. There are 3 aims o...

  17. Complete Genome Sequence of Highly Virulent Haemophilus parasuis Serotype 11 Strain SC1401

    Science.gov (United States)

    Dai, Ke; Jin, Jin; Wen, Xintian; He, Lvqin; Cao, Sanjie; Huang, Xiaobo; Wu, Rui; Zhao, Qin

    2016-01-01

    Haemophilus parasuis, a normal Gram-negative bacterium, may cause Glässer’s disease and pneumonia in pigs. This study aims to identify the genes related to natural competence of the serotype 11 strain SC1401, which frequently shows competence and high pathogenicity. SC1401 shows many differences from strains without natural competence within the molecular basis. We performed complete genome sequencing together with restriction modification system analysis to lay the foundation for later study. PMID:27445368

  18. Early Stages of Precipitation Process in Al-(Mn-)Sc-Zr Alloy Characterized by Positron Annihilation

    KAUST Repository

    Vlach, Martin

    2015-01-29

    Thermal effects on the precipitation stages in as-cast Al-0.70 at. pct Mn-0.15 at. pct Sc-0.05 at. pct Zr alloy were studied. The role of lattice defects was elucidated by positron annihilation spectroscopy (lifetime and coincidence Doppler broadening) enabling investigation of solutes clustering at the atomic scale. This technique has never been used in the Al-Sc- and/or Al-Zr-based alloys so far. Studies by positron annihilation were combined with resistometry, hardness measurements, and microstructure observations. Positrons trapped at defects are preferentially annihilated by Sc electrons. Lifetime of trapped positrons indicates that Sc atoms segregate at dislocations. Maximum fraction of positrons annihilated by Sc electrons occurring at 453 K (180 °C) suggests that clustering of Sc bound with vacancies takes place. It is followed by peak of this fraction at 573 K (300 °C). A rise of the contribution of trapped positrons annihilated by Zr electrons starting at 513 K (240 °C) and attaining maximum also at 573 K (300 °C) confirms that Zr participates in precipitation of the Al3Sc particles already at these temperatures. The pronounced hardening at 573 K (300 °C) has its nature in the precipitation of the Al3Sc particles with a Zr-rich shell. The contribution of trapped positrons annihilated by Mn electrons was found to be negligible. © 2015, The Minerals, Metals & Materials Society and ASM International.

  19. Stability of 47Sc-complexes with acyclic polyamino-polycarboxylate ligands

    OpenAIRE

    Połosak, Magdalena; Piotrowska, Agata; Krajewski, Seweryn; Bilewicz, Aleksander

    2012-01-01

    The aim of this study was to evaluate acyclic ligands which can be applied for labeling proteins such as monoclonal antibodies and their fragments with scandium radionuclides. Recently, scandium isotopes (47Sc, 44Sc) are more available and their properties are convenient for radiotherapy or PET imaging. They can be used together as “matched pair” in theranostic approach. Because proteins denaturize at temperature above 42 °C, ligands which efficiently form complexes at room temperature, are n...

  20. CMS ECAL Endcap (EE) Dee Assembly - SC mounting on Dee 1

    CERN Multimedia

    Cockerill, D

    2007-01-01

    Protection panels on back of Dee 1, Completion of SC mounting, 03/10/2007: Completion of SC mounting (aart from the inner 3-2-1)on the first quadrant of Dee 1 and subsequent survey. 22-28/08/2007: The first supercrystals on Dee1, Dee1 in 867 with the first column of SCs ready for mounting, Dee1 with its protection panels over the laser monitoring fibre system

  1. Strategisk anarki : en utredning av WeActivists strategiska funktion inom WeSC

    OpenAIRE

    Leijonborg, Lindström, Frida, Nils

    2013-01-01

    ABSTRACT Title: Strategic Anarchy – a study on WeActivists' communicative function inside WeSC. Number of pages: 69 Authors: Frida Leijonborg, Nils Lindström Tutor: Jessica Gustafsson Course: Media and communication studies C Period: Second term 2013 University: Division of Media and Communication, department of information science, Uppsala University Purpose: Our aim with this paper is to examine the communicative role WeActivists play in WeSC's external communication, and also to investiga...

  2. A Top-Down Optimization Methodology for SC Filter Circuit Design Using Varying Goal Specifications

    OpenAIRE

    Serra, Hugo; Santos-Tavares, Rui; Paulino, Nuno

    2014-01-01

    Part 19: Electronics: Design International audience The design of Switched-Capacitor (SC) filters can be an arduous process, which becomes even more complex when the high gain amplifier is replaced by a low gain amplifier or a voltage follower. This eliminates the virtual ground node, requiring the compensation of the parasitic capacitances during the design phase. This paper proposes an automatic procedure for the design of SC filters using low gain amplifiers, based on a Genetic Algor...

  3. Electronic structure of cubic ScF$_3$ from first-principles calculations

    OpenAIRE

    Zhgun, P.; Bocharov, D.; Piskunov, S.; Kuzmin, A; Purans, J.

    2012-01-01

    The first-principles calculations have been performed to investigate the ground state properties of cubic scandium trifluoride (ScF$_3$) perovskite. Using modified hybrid exchange-correlation functionals within the density functional theory (DFT) we have comprehensively compared the electronic properties of ScF$_3$ obtained by means of the linear combination of atomic orbitals (LCAO) and projector augmented-waves (PAW) methods. Both methods allowed us to reproduce the lattice constant experim...

  4. Magnetic dipole moment of the doubly closed-shell plus one proton nucleus $^{49}$Sc

    CERN Multimedia

    Gaulard, C V; Walters, W; Nishimura, K; Muto, S; Bingham, C R

    It is proposed to measure the magnetic moment of $^{49}$Sc by the Nuclear Magnetic Resonance on Oriented Nuclei (NMR-ON) method using the NICOLE on-line nuclear orientation facility. $^{49}$Sc is the neutron rich, doubly closed-shell, nucleus $^{48}$Ca plus one proton. Results will be used to deduce the effective g-factors in the $^{48}$Ca region with reference to nuclear structure and meson exchange current effects.

  5. Authenticated, private, and secured smart cards (APS-SC)

    Science.gov (United States)

    Szu, Harold; Mehmood, Amir

    2006-04-01

    From historical perspective, the recent advancements in better antenna designs, low power circuitry integrations and inexpensive fabrication materials have made possible a miniature counter-measure against Radar, a clutter behaving like a fake target return called Digital Reflection Frequency Modulation (DRFM). Such a military counter-measure have found its way in the commerce as a near field communication known as Radio Frequency Identification (RFID), a passive or active item tag T attached to every readable-writable Smart Card (SC): Passports ID, medical patient ID, biometric ID, driver licenses, book ID, library ID, etc. These avalanche phenomena may be due to the 3 rd Gen phones seeking much more versatile & inexpensive interfaces, than the line-of-sight bar-code optical scan. Despite of the popularity of RFID, the lacking of Authenticity, Privacy and Security (APS) protection restricted somewhat the wide spread commercial, financial, medical, legal, and militarily applications. Conventional APS approach can obfuscate a private passkey K of SC with the tag number T or the reader number R, or both, i.e. only T*K or R*K or both will appear on them, where * denotes an invertible operation, e.g. EXOR, but not limited to it. Then, only the authentic owner, knowing all, can inverse the operation, e.g. EXOR*EXOR= I to find K. However, such an encryption could be easily compromised by a hacker seeking exhaustively by comparison based on those frequently used words. Nevertheless, knowing biological wetware lesson for power of pairs sensors and Radar hardware counter-measure history, we can counter the counter-measure DRFM, instead using one RFID tag per SD, we follow the Nature adopting two ears/tags, e.g. each one holding portions of the ID or simply two different ID's readable only by different modes of the interrogating reader, followed by brain central processor in terms of nonlinear invertible shufflers mixing two ID bits. We prefer to adopt such a hardware

  6. A blue-emitting Sc silicate phosphor for ultraviolet excited light-emitting diodes.

    Science.gov (United States)

    Wang, Qian; Zhu, Ge; Xin, Shuangyu; Ding, Xin; Xu, Ju; Wang, Yuansheng; Wang, Yuhua

    2015-11-01

    A blue-emitting phosphor BaSc2Si3O10:Eu(2+) was synthesized using the conventional solid-state reaction. The crystallographic occupancy of Eu(2+) in the BaSc2Si3O10 matrix was studied based on the Rietveld refinement results and the photoluminescence properties. BaSc2Si3O10 exhibits blue emission ascribed to (3)T2-(1)A1 and (3)T1-(1)A1 charge transfer of SiO4(4-) excited by 360 nm. All the phosphors of BaSc2Si3O10:Eu(2+) exhibit strong broad absorption bands in the near ultraviolet range, and give abnormal blue emission upon 330 nm excitation. The abnormal phenomenon was explored in detail through many pieces of experimental evidence. The concentration of Eu(2+) is optimized to be 3 mol% according to emission intensity and the quenching mechanism is verified to be a quadrupole-quadrupole interaction. The CIE coordinates of BaSc2Si3O10:0.03Eu(2+) are calculated to be (0.15, 0.05) and BaSc2Si3O10:0.03Eu(2+) shows similar thermal stability to commercial BaMgAl10O17:Eu(2+). PMID:26242881

  7. Structural, electronic and elastic properties of M2SC (M = Ti, Zr, Hf) compounds

    International Nuclear Information System (INIS)

    Using ab initio calculations, we have studied the structural, electronic and elastic properties of M2SC, with M = Ti, Zr and Hf. Geometrical optimization of the unit cell are in good agreement with the available experimental data. The band structures show that all three materials are conducting. The analysis of the site and momentum projected densities shows that the bonding is achieved through a hybridization of M-atom d states with S and C-atom p states. The Md-Sp bonds are lower in energy and are stiffer than Md-Cp bonds. The elastic constants are calculated using the static finite strain technique. We derived the bulk and shear moduli, Young's moduli and Poisson's ratio for ideal polycrystalline M2SC aggregates. We estimated the Debye temperature of M2SC from the average sound velocity. This is a quantitative theoretical prediction of the elastic properties of Ti2SC, Zr2SC, and Hf2SC compounds, and it still awaits experimental confirmation

  8. Refolded scFv Antibody Fragment against Myoglobin Shows Rapid Reaction Kinetics

    Directory of Open Access Journals (Sweden)

    Hyung-Nam Song

    2014-12-01

    Full Text Available Myoglobin is one of the early biomarkers for acute myocardial infarction. Recently, we have screened an antibody with unique rapid reaction kinetics toward human myoglobin antigen. Antibodies with rapid reaction kinetics are thought to be an early IgG form produced during early stage of in vivo immunization. We produced a recombinant scFv fragment for the premature antibody from Escherichia coli using refolding technology. The scFv gene was constructed by connection of the VH–VL sequence with a (Gly4Ser3 linker. The scFv fragment without the pelB leader sequence was expressed at a high level, but the solubility was extremely low. A high concentration of 8 M urea was used for denaturation. The dilution refolding process in the presence of arginine and the redox reagents GSH and GSSH successfully produced a soluble scFv protein. The resultant refolded scFv protein showed association and dissociation values of 9.32 × 10−4 M−1·s−1 and 6.29 × 10−3 s−1, respectively, with an affinity value exceeding 107 M−1 (kon/koff, maintaining the original rapid reaction kinetics of the premature antibody. The refolded scFv could provide a platform for protein engineering for the clinical application for diagnosis of heart disease and the development of a continuous biosensor.

  9. Proteolytic enzyme conjugated to SC-glucan as an enzymatic transdermal drug penetration enhancer.

    Science.gov (United States)

    Sim, Y C; Nam, Y S; Shin, Y H; Shin, E; Kim, S; Chang, I S; Rhee, J S

    2003-04-01

    The objective of this study was to investigate the effect of papain, a proteolytic enzyme, on the percutaneous absorption of drugs. To guarantee the enzyme stability during the skin penetration, papain was modified by the conjugation to SC-glucan. The enhancing activity of drug penetration was evaluated using antipyrine and indomethacin as hydrophilic and hydrophobic model drugs, respectively. The SC-glucan-papain conjugate was found to be very effective for facilitating the percutaneous absorption of antipyrine. Microscopic observations showed that the thickness of stratum corneum and viable epidermis was increased by the treatment of the SC-glucan-papain conjugate. Moreover, it induced phase separation, lacuna formation, and lamellar disruption within the stratum corneum interstices. These structural changes by the SC-glucan-papain conjugate are likely to be induced from hydrolysis of extensive crosslinking of corneocyte envelopes and intracellular proteins. However, the SC-glucan-papain conjugate showed no skin irritation according to the Draize test, which may be due to the difficulty of the SC-glucan-papain conjugate in penetrating into the skin. PMID:12749407

  10. Refolded scFv antibody fragment against myoglobin shows rapid reaction kinetics.

    Science.gov (United States)

    Song, Hyung-Nam; Jang, Jun-Hyuck; Kim, Young-Wan; Kim, Dong-Hyung; Park, Sung-Goo; Lee, Myung Kyu; Paek, Se-Hwan; Woo, Eui-Jeon

    2014-01-01

    Myoglobin is one of the early biomarkers for acute myocardial infarction. Recently, we have screened an antibody with unique rapid reaction kinetics toward human myoglobin antigen. Antibodies with rapid reaction kinetics are thought to be an early IgG form produced during early stage of in vivo immunization. We produced a recombinant scFv fragment for the premature antibody from Escherichia coli using refolding technology. The scFv gene was constructed by connection of the V(H)-V(L) sequence with a (Gly4Ser)3 linker. The scFv fragment without the pelB leader sequence was expressed at a high level, but the solubility was extremely low. A high concentration of 8 M urea was used for denaturation. The dilution refolding process in the presence of arginine and the redox reagents GSH and GSSH successfully produced a soluble scFv protein. The resultant refolded scFv protein showed association and dissociation values of 9.32 × 10⁻⁴ M⁻¹·s⁻¹ and 6.29 × 10⁻³ s⁻¹, respectively, with an affinity value exceeding 10⁷ M⁻¹ (k(on)/k(off)), maintaining the original rapid reaction kinetics of the premature antibody. The refolded scFv could provide a platform for protein engineering for the clinical application for diagnosis of heart disease and the development of a continuous biosensor. PMID:25530617

  11. Estimation of collimator scatter factor, Sc, of rectangular fields by a saturation model

    International Nuclear Information System (INIS)

    We estimated collimator scatter factor, Sc, of symmetric rectangular fields of any size by applying a two-component scatter model to measured in-air output data in width and length directions of measured rectangles. The in-air output was measured for symmetric rectangles with combined width and length sizes of 7 x 7 and 6 x 6 using 10 MV and 4 MV X-rays of Varian's Clinac 2100 C/D, respectively. The model consists of scatter components from the primary collimator and flattening filter and from the collimator jaws: the former shows a saturation curve and the latter increases linearly with enlarging field size. This model was fitted to the measured dataset firstly in the width and secondly in the length directions of rectangles; then, by compiling interpolated matrix data, the Sc table of symmetric rectangles was constructed. In addition, using this Sc table, values of Sc were calculated for a few asymmetric rectangles by Day's method, and were in good agreement with measured values. Therefore, we think that our method is practical and precise for constructing the Sc table of symmetric rectangles from measured data, and that using this table, the Sc of any asymmetric rectangles may be calculated. (author)

  12. Conceptual Design of the TPF-O SC Bus

    Science.gov (United States)

    Purves, Lloyd R.

    2007-01-01

    One option under current study for the Terrestrial Planet Finder-Occulter (TPF-O) observatory shares some key features of the Hubble Space Telescope (HST). Both are space telescopes with a primary mirror aperture of around 2.4 meters and designed to observe in the visible to near infrared range of wavelengths, with the major difference in science capability being that TPF-O has an areal FOV on the order of 100 times larger than that of HST. This larger FOV, whose science camera is also expected to provide fine guidance, and other mission differences, mean that most TPF-O SC bus subsystems will have very different requirements than those of HST. Unlike HST in LEO, TPF-O is designed to operate in an orbit around the Sun-Earth lagrange 2 (SEL2) point. The longer communications range to SEL2 and the large FOV require much higher performance data processing and communications than HST. Maintaining a SEL2 orbit requires TPF-O, unlike HST, to have a propulsion system. TPF-O will have a specialized tracking system that allows the formation flying occulter to maintain its required position. However, despite these additional features, the velocity required for reaching SEL2 and the limited capabilities of affordable launch vehicles require TPF-O to have a compact and low-mass design relative to HST. Finally, TPF-O may utilize a modular design to reduce development cost and, if it required, allow servicing using approaches different from those of HST.

  13. One-neutron knockout from {sup 51-55}Sc

    Energy Technology Data Exchange (ETDEWEB)

    Schwertel, S.; Maierbeck, P.; Gernhaeuser, R.; Bildstein, V.; Boehmer, M.; Eppinger, K.; Faestermann, T.; Friese, J.; Fabbietti, L.; Maier, L.; Winkler, S. [Technische Universitaet Muenchen, Physik Department E12, Garching (Germany); Kruecken, R. [Technische Universitaet Muenchen, Physik Department E12, Garching (Germany); TRIUMF, Vancouver (Canada); University of British Columbia, Department of Physics and Astronomy, Vancouver (Canada); Kroell, T. [Technische Universitaet Muenchen, Physik Department E12, Garching (Germany); Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Alvarez-Pol, H.; Benjamim, E.A.; Benlliure, J.; Caamano, M.; Cortina-Gil, D.; Gascon, M.; Kurtukian, T.; Perez, D.; Rodriguez-Tajes, C. [Universidade de Santiago de Compostela, Departamento de Fisica de Particulas, Santiago de Compostela (Spain); Aksouh, F.; Aumann, T.; Behr, K.; Boretzky, K.; Bruenle, A.; Chatillon, A.; Chulkov, L.V.; Geissel, H.; Gerl, J.; Gorska, M.; Kojouharov, I.; Klimkiewicz, A.; Kurz, N.; Nociforo, C.; Schaffner, H.; Simon, H.; Stanoiu, M.; Suemmerer, K.; Weick, H. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Borge, M.J.G.; Pascual-Izarra, C.; Perea, A.; Tengblad, O. [CSIC, Instituto de Estructura de la Materia, Madrid (Spain); Buerger, A. [University of Oslo, SAFE/OCL, Oslo (Norway); CEA, Gif-sur-Yvette (France); Casarejos, E.; Brown, B.A. [University of Vigo, Vigo (Spain); Enders, J.; Schrieder, G. [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Hansen, P.G. [Michigan State University, NSCL, East Lansing, Michigan (United States); Jonson, B.; Nyman, G. [Chalmers Tekniska Hoegskola och Goeteborgs Universitet, Experimentell Fysik, Goeteborg (Sweden); Kanungo, R. [TRIUMF, Vancouver (Canada); GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Saint Mary' s University, Halifax (Canada); Kiselev, O. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Johannes Gutenberg Universitaet, Mainz (Germany); Paul Scherrer Institut, Villigen (Switzerland); Larsson, K. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Chalmers Tekniska Hoegskola och Goeteborgs Universitet, Experimentell Fysik, Goeteborg (Sweden); Le Bleis, T. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); IN2P3-CNRS/Universite Louis Pasteur, Institut Pluridisciplinaire Hubert Curien, Strasbourg Cedex 2 (France); Mahata, K. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Paul Scherrer Institut, Villigen (Switzerland); Nilsson, T. [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Chalmers Tekniska Hoegskola och Goeteborgs Universitet, Experimentell Fysik, Goeteborg (Sweden); Prochazka, A. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Comenius University, Faculty of Mathematics and Physics, Bratislava (Slovakia); Rossi, D. [Johannes Gutenberg Universitaet, Mainz (Germany); Sitar, B. [Comenius University, Faculty of Mathematics and Physics, Bratislava (Slovakia); Otsuka, T. [University of Tokyo, Hongo, Bunkyo-ku, Department of Physics, Tokyo (Japan); Tostevin, J.A. [University of Surrey, Department of Physics, Faculty of Engineering and Physical Sciences, Guildford (United Kingdom); Rae, W.D.M. [Garsington, Oxfordshire (United Kingdom)

    2012-12-15

    Results are presented from a one-neutron knockout experiment at relativistic energies of {approx} 420 A MeV on {sup 51-55}Sc using the GSI Fragment Separator as a two-stage magnetic spectrometer and the MINIBALL array for gamma-ray detection. Inclusive longitudinal momentum distributions and cross-sections were measured enabling the determination of the contributions corresponding to knockout from the {nu}p{sub 1/2}, {nu}p{sub 3/2}, (L = 1) and {nu}f{sub 7/2}, {nu}f{sub 5/2} (L = 3) neutron orbitals. The observed L = 1 and L = 3 contributions are compared with theoretical cross-sections using eikonal knockout theory and spectroscopic factors from shell model calculations using the GXPF1A interaction. The measured inclusive knockout cross-sections generally follow the trends expected theoretically and given by the spectroscopic strength predicted from the shell model calculations. However, the deduced L = 1 cross-sections are generally 30-40% higher while the L = 3 contributions are about a factor of two smaller than predicted. This points to a promotion of neutrons from the {nu}f{sub 7/2} to the {nu}p{sub 3/2} orbital indicating a weakening of the N = 28 shell gap in these nuclei. While this is not predicted for the phenomenological GXPF1A interaction such a weakening is predicted by recent calculations using realistic low-momentum interactions V{sub low} {sub k} obtained by evolving a chiral N3LO nucleon-nucleon potential. (orig.)

  14. SC2: a System to Secure Off-Card Contract-Policy Matching in Security-by-Contract for Open Multi-Application Smart Cards

    DEFF Research Database (Denmark)

    Dragoni, Nicola; Lostal, Eduardo; Papini, Davide

    2011-01-01

    smart card hosting the application. In this demonstration we show (SC)2 (Secure Communication over Smart Cards), a system developed to address a key issue of the SC framework, namely the secure outsourcing of the SC contract-policy matching service to a Trusted Third Party (TTP). (SC)2 secures the...... communication between a smart card and the TTP that provides the SC matching service....

  15. Two-gap superconductivity in R2Fe3Si5 (R=Lu, Sc and Sc5Ir4Si10

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Tamegai, Yasuyuki Nakajima, Tsuyoshi Nakagawa, Guoji Li and Hisatomo Harima

    2008-01-01

    Full Text Available R2Fe3Si5 (R= Sc, Y, Lu contains nonmagnetic iron and has a relatively high superconducting transition temperature Tc among iron-containing superconductors. An anomalous temperature dependence of specific heat C(T has been reported for polycrystalline samples down to 1 K. We have grown R2Fe3Si5 single crystals, confirmed the anomalous C(T dependence, and found a second drop in specific heat below 1 K. In Lu2Fe3Si5, we can reproduce C(T below Tc, assuming two distinct energy gaps 2Δ 1/kBTc = 4.4 and 2Δ 2/kBTc = 1.1, with nearly equal weights, indicating that Lu2Fe3Si5 is a two-gap superconductor similar to MgB2. Hall coefficient measurements and band structure calculation also support the multiband contributions to the normal-state properties. The specific heat in the Sc2Fe3Si5 single crystals also shows the two-gap feature. R5Ir4Si10 (R = Sc, rare earth is also a superconductor where competition between superconductivity and the charge-density wave is known for rare earths but not for Sc. We have performed detailed specific heat measurements on Sc5Ir4Si10 single crystals and found that C(T deviates slightly from the behavior expected for weak-coupling superconductors. C(T for these superconductors can also be reproduced well by assuming two superconducting gaps.

  16. Low Temperature Synthesis and Characterization of AlScMo3O12

    Directory of Open Access Journals (Sweden)

    Rebecca Truitt

    2015-02-01

    Full Text Available Recent interest in low and negative thermal expansion materials has led to significant research on compounds that exhibit this property, much of which has targeted the A2M3O12 family (A = trivalent cation, M = Mo, W. The expansion and phase transition behavior in this family can be tuned through the choice of the metals incorporated into the structure. An undesired phase transition to a monoclinic structure with large positive expansion can be suppressed in some solid solutions by substituting the A-site by a mixture of two cations. One such material, AlScMo3O12, was successfully synthesized using non-hydrolytic sol-gel chemistry. Depending on the reaction conditions, phase separation into Al2Mo3O12 and Sc2Mo3O12 or single-phase AlScMo3O12 could be obtained. Optimized conditions for the reproducible synthesis of stoichiometric, homogeneous AlScMo3O12 were established. High resolution synchrotron diffraction experiments were carried out to confirm whether samples were homogeneous and to estimate the Al:Sc ratio through Rietveld refinement and Vegard’s law. Single-phase samples were found to adopt the orthorhombic Sc2W3O12 structure at 100 to 460 K. In contrast to all previously-reported A2M3O12 compositions, AlScMo3O12 exhibited positive thermal expansion along all unit cell axes instead of contraction along one or two axes, with expansion coefficients (200–460 K of αa = 1.7 × 10−6 K−1, αb = 6.2 × 10−6 K−1, αc = 2.9 × 10−6 K−1 and αV = 10.8 × 10−6 K−1, respectively.

  17. Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

    International Nuclear Information System (INIS)

    CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance

  18. Soluble Expression and Characterization of a New scFv Directed to Human CD123.

    Science.gov (United States)

    Moradi-Kalbolandi, Shima; Davani, Dariush; Golkar, Majid; Habibi-Anbouhi, Mahdi; Abolhassani, Mohsen; Shokrgozar, Mohammad Ali

    2016-04-01

    Leukemic cancer stem cells (LSCs), as a unique cell population in acute myeloid leukemia (AML) marked by CD123 overexpression, are thought to play a key role in relapsed AML after chemotherapy. Thus, CD123 is considered as a particularly important target candidate for antibody-derived diagnosis and therapy. In the present work, we constructed an immunized murine antibody phage display library and isolated the functional anti-CD123 Single-chain fragment variable (scFv) clones. We also introduced fusing variable light (VL) and heavy (VH) chains with a new 18-amino acid residue linker as an alternative to conventional linkers. CD123-specific phage clones were progressively enriched through 4 rounds of biopanning, validated by phage ELISA, and anti-CD123 scFv clones with highest affinity were produced in Escherichia coli. The expression and purification of soluble scFv were verified by Western blot, and the results were indicative of the functionality of our proposed linker. The purified scFv specifically recognized CD123 by ELISA and flow cytometry, without any cross-reactivity with other related cell markers. Affinity of anti-CD123 scFv was measured to be 6.9 × 10(-7) M, using the competitive ELISA. Our work, therefore, provides a framework for future studies involving biological functions and applications of our anti-CD123 scFv. It also reveals the feasibility of high throughput methods to isolate biomarker-specific scFvs. PMID:26749295

  19. The inhibition of lung cancer cell growth by intracellular immunization with LC-1 ScFv

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A monoclonal antibody, LC-l, recognizing lung cancer associated common antigens was obtained in authors' laboratory. Its single chain Fv fragment (ScFv) named LC-1 ScFv was constructed based on recombinant phage displayed techniques. For expression on cell membrane, LC-1 ScFv was cloned into pDisplay vector, which directed the cloned gene to express as cell membrane bound protein. The resulting plasmid was sequenced and then introduced by the lipofectin method into a lung adenocarcinoma cell line SPC-A-1. G418 resistant cells were obtained by G418 selection. After transfection, LC-1 ScFv expression was observed by Western blot analysis and the expression of cognate antigens was down-regulated as shown in ELISA assay. SPC-A-1-pDisplay-ScFv cells grew in vitro at lower speed than the control intact cells and the cells transfected with vacant vector. Flow cytometry analysis detected a substantial increase in G1 phase and decrease in S phase in population of SPC-A-1-pDisplay-ScFv cells compared to SPC-A-1 and SPC-A1-pDisplay cells. Semi-quantitative RT-PCR analysis showed that c-myc expression was down-regulated in SPC-A-1-pDisplay-ScFv cells. It seems that the antigens recognized by LC-1 may be in some way involved in a growth stimulating pathway and the antibody blocking of the function of the antigens shut down the pathway and thus down-regulate the expression of c-myc and growth of the cells.

  20. A Global Record of Surface Earth Oxygenation from Sedimentary V/Sc

    Science.gov (United States)

    Keller, C. B.; Schoene, B.; Johnston, D. T.

    2015-12-01

    One of the simplest methods to investigate changes in oxidation potential in geologic environments is to examine a pair of otherwise similar elements with dramatically different redox chemistry. The first-row transition metals Sc and V represent one such pair, with generally similar mass, radius, and ionization energies up to the trivalent redox state. However, as a d3 transition metal, Sc is limited to a maximum oxidation state of 3+, while d5 vanadium may be further oxidized to form tetravalent and pentavalent ions. Due to the greater incompatibility of pentavalent (relative to trivalent) metal cations in silicate melts, V/Sc ratio has been applied to the silicate rock record as a tracer of magma redox - indicating roughly constant mantle oxygen fugacity over Earth history1,2. As a result, the solid earth represents a boundary condition with constant V/Sc observed over geologic time1. However, oxidation state also affects the weathering, solubility, and coordination behaviour of V and Sc, resulting in a potential redox signal in the sedimentary V/Sc record. We apply the weighted bootstrap resampling approach of [2] to a geochemical dataset of ~87,000 sedimentary whole-rock analyses from the EarthChem portal3. The resulting trends reveal a 4 Gyr record of V/Sc redox chemistry, with the great oxidation event represented as an upward step ca. 2.5 Ga, and Phanerozoic variation suggestive of low oxygen in the early Paleozoic, increasing to twin maxima circa 270 Ma and 130 Ma, remarkably similar to that predicted by the COPSE model4, and broadly congruent with the Phanerozoic biochar record5. Li, Z.-X. A. & Lee, C.-T. A. EPSL 228, 483-493 (2004). Keller, C. B. & Schoene, B. Nature 485, 490-493 (2012). EarthChem Bergman, N. M. Am. J. Science 304, 397-437 (2004). Glasspool, I. J. & Scott, A. C. Nat. Geosci. 3, 627-630 (2010).

  1. New Scandium Platinum Silicides: ScPt2Si with `Inverse? MgCuAl2 Structure, and Sc5Pt9Si7, a Variant of the Zr2Fe12P7-Type

    OpenAIRE

    Jung, Walter

    2009-01-01

    Abstract Two new scandium platinum silicides, ScPt2Si (orthorhombic, Cmcm, a = 3.6653(6) ?, b = 9.831(1) ?, c = 6.967(1) ?, Z = 4) and Sc5Pt9Si7 (hexagonal, P?6, a = 9.9418(5) ?, c = 3.8832(2) ?, Z = 1) were prepared by reaction of the elements in an electric arc furnace and subsequent annealing. The crystal structures were solved and refined from single crystal diffraction data. ScPt2Si crystallizes with an `inverse? MgCuAl2 structure while Sc5Pt9Si7 forms a variant of the Zr2Fe...

  2. Modeling of an anode-supported Ni-YSZ vertical stroke Ni-ScSZ vertical stroke ScSZ vertical stroke LSM-ScSZ multiple layers SOFC cell. Part II. Simulations and discussion

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Yixiang; Cai, Ningsheng; Li, Chen; Bao, Cheng [Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084 (China); Croiset, Eric [Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1 (Canada); Qian, Jiqin; Hu, Qiang; Wang, Shaorong [Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS), 1295 Dingxi Road, Shanghai 200050 (China)

    2007-10-11

    In part I of the present study, a two-dimensional isothermal mechanistic model of a composite yttria/scandia stabilized zirconia anode-supported multiple layers solid oxide fuel cell (Ni-YSZ vertical stroke Ni-ScSZ vertical stroke ScSZ vertical stroke LSM-ScSZ) was developed, calibrated and validated using a button cell setup. In this paper, the model was further validated for extended operating conditions of fuel and oxidant compositions, which confirmed the robustness of the model. Since an important attribute of this model is its ability to accurately describe the effect of cell microstructure on cell performance, a large section of part II is devoted to sensitivity analysis of various microstructure parameters (cathode area, porosity, layer thickness and particle radius) on cell performance. In particular, the simulation results have shown how the button cell microstructure should be modified to optimize its performance. The proposed model could be used as a bridge between micro-scale electrode models and macro-scale unit cell simulation, thus being a useful tool for electrode design. (author)

  3. K2SC: Flexible systematics correction and detrending of K2 light curves using Gaussian Process regression

    OpenAIRE

    Aigrain, Suzanne; Parviainen, Hannu; Pope, Benjamin

    2016-01-01

    We present K2SC (K2 Systematics Correction), a Python pipeline to model instrumental systematics and astrophysical variability in light curves from the K2 mission. K2SC uses Gaussian process regression to model position-dependent systematics and time-dependent variability simultaneously, enabling the user to remove both (e.g., for transit searches) or to remove systematics while preserving variability (for variability studies). For periodic variables, K2SC automatically computes estimates of ...

  4. Effect of Sc2O3 particles on the microstructure and properties of tungsten alloy prepared by spark plasma sintering

    International Nuclear Information System (INIS)

    Highlights: • Effect of Sc2O3 on microstructure and properties of tungsten alloy were studied. • Sc2O3 significantly refined the grain size and increased the density of tungsten alloy. • The tensile strength values of the W–2 vol%Sc2O3 samples were higher than the others. - Abstract: W–Sc2O3 composite powders (W, W–0.5 vol%Sc2O3, and W–2 vol%Sc2O3) doped with highly uniform Sc2O3 particles were successfully synthesized by mechanical alloying followed by hydrogen reduction with Sc2O3 and WO3 powders. The reduced powders were then consolidated by spark plasma sintering at 1700 °C to suppress grain growth during sintering. Field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and high-resolution transmission electron microscopy analyses, as well as tensile tests and thermal conductivity measurements, were used to characterize the samples. The results showed that the Sc2O3 particles were uniformly distributed in the tungsten grains and grain boundaries. The W–2vol%Sc2O3 composite possess the best relative density and Vickers micro-hardness up to 98.6% and 683.2 Hv, respectively. The Sc2O3 particles significantly refine the grain size and increase the density of tungsten alloy. With increased Sc2O3 content, the thermal conductivity decreased while tensile strength of the samples respectively increased at 700 and 800 °C

  5. AlScN thin film based surface acoustic wave devices with enhanced microfluidic performance

    Science.gov (United States)

    Wang, W. B.; Fu, Y. Q.; Chen, J. J.; Xuan, W. P.; Chen, J. K.; Wang, X. Z.; Mayrhofer, P.; Duan, P. F.; Bittner, A.; Schmid, U.; Luo, J. K.

    2016-07-01

    This paper reports the characterization of scandium aluminum nitride (Al1‑x Sc x N, x  =  27%) films and discusses surface acoustic wave (SAW) devices based on them. Both AlScN and AlN films were deposited on silicon by sputtering and possessed columnar microstructures with (0 0 0 2) crystal orientation. The AlScN/Si SAW devices showed improved electromechanical coupling coefficients (K 2, ~2%) compared with pure AlN films (liquid droplets, and the acoustic streaming and pumping velocities were 2  ×  and 3  ×  those of the AlN/Si SAW devices, respectively. Mechanical characterization showed that the Young’s modulus and hardness of the AlN film decreased significantly when Sc was doped, and this was responsible for the decreased acoustic velocity and resonant frequency, and the increased temperature coefficient of frequency, of the AlScN SAW devices.

  6. Unexpected magnetic behavior in amorphous Co{sub 90}Sc{sub 10} alloy

    Energy Technology Data Exchange (ETDEWEB)

    Ghafari, M., E-mail: mohammad.ghafari@kit.edu, E-mail: skamali@utsi.edu; Gleiter, H. [Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing 210094 (China); Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany); Sakurai, Y.; Itou, M. [Japan Synchrotron Radiation Research Institute (JASRI), SPring-8, 1-1-1 Kouto, Sayo, Sayo, Hyogo (Japan); Peng, G.; Fang, Y. N.; Feng, T. [Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing 210094 (China); Hahn, H. [Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing 210094 (China); Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany); KIT-TUD Joint Research Laboratory Nanomaterials, Institute of Materials Science, Technische Universität Darmstadt (TUD), Jovanka-Bontschits-Str. 2, 64287 Darmstadt (Germany); Kamali, S., E-mail: mohammad.ghafari@kit.edu, E-mail: skamali@utsi.edu [Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee Space Institute, Tullahoma, Tennessee 37388 (United States)

    2015-09-28

    An amorphous alloy Co{sub 90}Sc{sub 10} has been prepared by rapid quenching from the melt. The results of magnetization measurements show that this alloy has the highest Curie temperature reported for any amorphous transition metal based alloys. Furthermore, for a Co based amorphous alloy, the magnetic moment is remarkably high. Moreover, the alloy exhibits soft magnetic properties. Based on the findings, amorphous Co{sub 90}Sc{sub 10} appears to be an attractive candidate for applications as a soft magnetic material. The temperature dependence of the reduced magnetization can be described by the Bloch power law. The results show that the B coefficient of the amorphous Co{sub 90}Sc{sub 10} alloy, which is a measure of the rigidity of spin waves, exhibits the lowest value observed until now for any amorphous alloy and is comparable to crystalline alloys. It is found that the Sc atoms in the Co{sub 90}Sc{sub 10} alloy lead to an increase of the itinerant spin moment of Co atoms, and, in contrast to this behaviour, to a decrease of the local 3d-electrons of Co.

  7. Fast conversion of scFv to Fab antibodies using type IIs restriction enzymes.

    Science.gov (United States)

    Sanmark, Hanna; Huovinen, Tuomas; Matikka, Tero; Pettersson, Tiina; Lahti, Maria; Lamminmäki, Urpo

    2015-11-01

    Single chain variable fragment (scFv) antibody libraries are widely used for developing novel bioaffinity reagents, although Fab or IgG molecules are the preferred antibody formats in many final applications. Therefore, rapid conversion methods for combining multiple DNA fragments are needed to attach constant domains to the scFv derived variable domains. In this study we describe a fast and easy cloning method for the conversion of single framework scFv fragments to Fab fragments using type IIS restriction enzymes. All cloning steps excluding plating of the Fab transformants can be done in 96 well plates and the procedure can be completed in one working day. The concept was tested by converting 69 scFv clones into Fab format on 96 well plates, which resulted in 93% success rate. The method is particularly useful as a high-throughput tool for the conversion of the chosen scFv clones into Fab molecules in order to analyze them as early as possible, as the conversion can significantly affect the binding properties of the chosen clones. PMID:26271437

  8. Roles of impurities on precipitation kinetics of dilute Al-Sc alloys

    International Nuclear Information System (INIS)

    High-purity (HP) aluminum and commercial purity (CP) aluminum (major impurities: ∼250 at. ppm Si and ∼130 at. ppm Fe) are alloyed with ∼250 to ∼1100 at. ppm Sc and ∼50 at. ppm RE (RE = La, Ce, Pr, or Nd). The alloys are homogenized at 640 deg. C and aged at 300 deg. C. The precipitation kinetics, basic mechanical properties, and microstructure are studied using AC electrical conductivity, microhardness measurements, scanning electron microscopy in conjunction with energy dispersive X-ray spectroscopy, and atom-probe tomography, respectively. The Fe and RE elements form micrometer-scale diameter Al∼3(Fe,RE) primary precipitates, which have no effect on the mechanical properties. Silicon accelerates the precipitation kinetics of nanometer-scale diameter Al3Sc precipitates, increasing their number density, thereby resulting in higher microhardness values for CP aluminum than the HP aluminum having the same Sc concentration. Additionally, the Sc equilibrium solubility in the α-Al matrix is estimated and Orowan's strengthening mechanism is confirmed for the Al3Sc precipitates.

  9. Spinal Cord Infarction in Hemoglobin SC Disease as an Amusement Park Accident.

    Science.gov (United States)

    Eid, Ryan; Raj, Ashok; Farber, Darren; Puri, Vinay; Bertolone, Salvatore

    2016-09-01

    Spinal cord infarction (SCI) is extremely rare in children, and only 2 other reports have described the occurrence of SCI in patients with hemoglobin SC disease (HbSC). Amusement park accidents are serious injuries. Patients with preexisting conditions, such as hypertension, cardiac disease, and recent back or neck injuries, may be at an increased risk. We report the case of a 12-year-old girl with HbSC with a past history of only 2 admissions for pain crises, who presented to the emergency department with symptoms of SCI after riding a roller coaster. Fibrocartilaginous embolism (FCE) is an increasingly recognized cause of SCI after events that put strain on the axial skeleton, such as many amusement park rides. Although radiologic criteria for FCE have been proposed, FCE remains a diagnosis of exclusion. To the best of our knowledge, this is the first documented case of SCI in a patient with HbSC and the first case of FCE after an amusement park accident. This case report highlights that HbSC may confound the differential diagnosis of SCI and aims to document an association with FCE in pediatric patients. PMID:27485695

  10. Influence of Sc3+ on LiMn2O4 cathode materials at elevated temperature

    Institute of Scientific and Technical Information of China (English)

    LIU Huiyong; DENG Ganqun; GUO Yonglang

    2008-01-01

    Sc3+-doped lithium manganese oxides were synthesized by solid-state reaction. The influences of doping element on structure,mean valence of manganese, and electrochemical performances were studied by X-ray diffraction (XRD), galvanostatic charge-discharge and cyclic voltammetric tests, and also electrochemical impedance spectroscopy (EIS). XRD tests showed that doped lithium manganese oxides were pure spinel structure without other phases. Redox titration and visible spectrophotometry tests indicated that the mean valence of man-ganese in doped lithium manganese oxides was higher than that of pure one. LiSc0.02Mn1.98O4 remained 92.9% of the initial specific discharge capacity after 50th cycle at a constant current of 50 m/g, and the reversibility of LiSc0.02Mn1.98O4 was improved in comparison with pure LiMn2O4 at 50 ℃. EIS indicated that film deposition on spinel particles was suppressed because of Sc3+ doping, and the charge transfer be-tween the surface film and spinel particles with increasing temperature for Sc3+-doped materials became easier as compared with undoped one.

  11. Spectrophotometric determination of Sc in eriochrome cyanine R(chrome azurol S) - phosphatidyl choline system

    International Nuclear Information System (INIS)

    Eriochrome cyanine R(chrome azurol S) is used as a color reagent to determine Sc in the presence of phosphatidyl choline, eta = 3.7 * 104 (4.5 * 104). This method has been connected to extraction separation to determine Sc in the presence of rare earth elements, and good results have been obtained. Phosphatidyl choline(PC) is a biochemical reagent, which can be used as a surfactant. It has been reported that chrome azurol S(CAS) can be used to determine Be in the presence of PC but it has not been reported that eriochrome cyanine R(ECR) and CAS can been used to determine Sc in the presence of PC. This paper has put forward a method by which Sc can be determined. ECR (CAS) has been used as a color reagent and PC as a surfactant. Conditional experiments have been made and this method has been connected to extraction separation. Tributyl phosphate (TBP) extracts Sc from rare earth elements to make a determination and good results have been obtained

  12. Construction of Human ScFv Phage Display Library against Ovarian Tumor

    Institute of Scientific and Technical Information of China (English)

    XIA Jinsong; BI Hao; YAO Qin; QU Shen; ZONG Yiqiang

    2006-01-01

    In order to construct a single chain fragment variable (ScFv) phage display library against ovarian tumor, by using RT-PCR, the human heavy chain variable region genes (VH) and light chain variable region genes (VL) were amplified from lymphocytes of ovarian tumor patients and subsequently assembled into ScFv genes by SOE. The resulting ScFv genes were electrotransformed into E.coli TG1 and amplified with the co-infection of helper phage M13KO7 to obtain phage display library. The capacity and titer of the resulting library were detected. The phage antibody library with a capacity of approximately 3 × 109 cfu/μg was obtained. After amplification with helper phage, the titer of antibody library reached 5 × 1012 cfu/mL. Human ScFv library against ovarian tumor was constructed successfully, which laid a foundation for the screening of ovarian tumor specific ScFv for the radioimmunoimaging diagnosis of ovarian tumor.

  13. Microstructure dependent fatigue crack growth in Al–Mg–Sc alloy

    International Nuclear Information System (INIS)

    The fatigue crack growth behavior of Al–Mg–Sc alloy was investigated by tensile testing and fatigue testing. Different annealing treatments were applied to the alloy. Microstructure characterization of the alloy was carried out by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and optical microscopy (OM). The size of Al3(Sc1−xZrx) particle was calculated by software. The fatigue crack growth (FCG) rate (da/dN) was discussed with stress intensity factor range (ΔK) in Paris's region. The Paris exponent m and constants C were used to calculate the fatigue life. The fatigue process and crack closure effects were discussed with the yield strength and tensile strength of Al–Mg–Sc alloy. Results show that the microstructure, tensile strength and fatigue crack growth rate were greatly dependent on the annealing temperature, and the high resistance of Al–Mg–Sc alloy was mainly due to the combination microstructures of sub-grains, dislocations and these Al3(Sc1−xZrx) precipitates

  14. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct.

    OpenAIRE

    Shadel, G S; Clayton, D A

    1995-01-01

    In Saccharomyces cerevisiae mitochondria, sc-mtTFB is a 341-amino-acid transcription factor required for initiation of transcription from mitochondrial DNA promoters. Specific transcription in vitro requires only sc-mtTFB and the bacteriophage-related core sc-mtRNA polymerase. Mutational analysis of sc-mtTFB has defined two regions of the protein that are important for normal function both in vivo and in vitro. These regions overlap portions of the protein that exhibit similarity to conserved...

  15. Vibrational structure of C 84 and Sc 2@C 84 analyzed by IR spectroscopy

    Science.gov (United States)

    Hulman, M.; Pichler, T.; Kuzmany, H.; Zerbetto, F.; Yamamoto, E.; Shinohara, H. N.

    1997-06-01

    The isomer III of Sc 2@C 84 was separated by multi-cycle HPLC purification. We present temperature dependent IR absorption measurements of Sc 2@C 84 which have been performed between 50 and 300 K and between 400 and 5000 cm -1, respectively. The vibrational structure of the endohedral compound is compared to the structure of unfilled C 84. We find a strong overall broadening of the vibrational modes in Sc 2@C 84. Also some of the vibrational absorption lines are strongly enhanced if compared to the spectrum for the empty cage. With decreasing temperature, a dramatic narrowing of the lines in the spectral range between 700 and 800 cm -1 is observed.

  16. Precursors to ScS Phases and dipping interface in the upper mantle beneath southwestern Japan

    Science.gov (United States)

    Nakanishi, Ichiro

    1980-10-01

    Longitudinally polarized precursors to ScS phases observed in the Shikoku and Chugoku districts, southwestern Japan, are interpreted as ScSp arrivals, resulting from ScSto-P conversions at a dipping interface in the upper mantle. An ScSp phase recorded in the Tohoku district, northeastern Japan, also is examined. The location of the conversion interface, beneath the Shikoku district, determined from the ScSp observations agrees with the upper boundary of the descending Philippine Sea plate inferred from the seismicity pattern of subcrustal earthquakes. It has been proposed on the basis of no seismic activity in the upper mantle that the leading edge of the downgoing Philippine Sea plate has not reached the upper mantle beneath the Chugoku district. The ScSp observations, however, present a possibility of the existence of an aseismic continuation of the Philippine Sea plate in the upper mantle beneath the Chugoku district. An alternative interpretation of the conversion interface may be possible. The interface inferred in the present study may correspond to a boundary between the asthenosphere and an aseismic dead slab which had descended from the Nankai trough at the previous cycle of plate convergence. This ScS-to-P conversion interface may be closely related to the late Quaternary volcanism in the Chugoku district. Low-velocity zones are required in the vicinity of the inclined ScS-to-P conversion interfaces in the upper mantle beneath southwestern and northeastern Japan in order to explain the observed relative polarity between the ScSp and ScS phases. The first-order discontinuity of the velocity contrast of about 6%, which has been suggested between the lithosphere and overlying asthenosphere, cannot simultaneously explain all of the observed amplitudes, periods, and polarity of the ScSp phases. The simplest model which explains these observations is the low-velocity zone with the sharp upper and transitional lower boundaries. This low-velocity zone may be

  17. Isospin-symmetry-hindered branch of 42Sc β-decay

    International Nuclear Information System (INIS)

    The branching fraction for the isospin-symmetry-hindered positron decay of 42Sc to 42Ca (1.837 MeV) was measured to be (6.3+-2.6)x105 by observation of delayed γ-rays. This branch alone corresponds to a reduction of the superallowed ground-state Fermi strength by (0.043+-0.018)%. The 42Sc sources were produced by the 42Ca(p,n)42Sc reaction at 7.7 MeV. The measured branching agrees with Coulomb-mixing calculations by Rappleyea and Kunz and by Towner, but is smaller than other calculations. This result is of interest in connection with the intercomparison of the superallowed 0+ → 0+ pure Fermi decays, which determine the effective vector coupling constant of nuclear β-decay. (Auth.)

  18. Magnetic anisotropy in the incommensurate ScFe{sub 4}Al{sub 8} system

    Energy Technology Data Exchange (ETDEWEB)

    Rećko, K., E-mail: k.recko@uwb.edu.pl [Faculty of Physics, University of Białystok, K. Ciołkowskiego 1L, 15-245 Białystok (Poland); Dobrzyński, L. [National Centre for Nuclear Research, A. Soltan 7, 05-400 Otwock-Świerk (Poland); Waliszewski, J.; Szymański, K. [Faculty of Physics, University of Białystok, K. Ciołkowskiego 1L, 15-245 Białystok (Poland)

    2015-08-15

    Neutron scattering and magnetization data are used for estimation of the spin ordering in ScFe{sub 4}Al{sub 8}. Results of experimental measurements are compared with the ground state configurations obtained by simulated annealing algorithms. The origins of the magnetocrystalline anisotropy of the scandium intermetallic alloy and the conditions of the coexistence of two different magnetic modulations as a function of the exchange integrals are discussed. The influence of the dipolar interactions for the noncollinearity and incommensurability in ScFe{sub 4}Al{sub 8} was determined. - Highlights: • We found dipolar and DM interactions as the anisotropy origins of 3d–3d–3p alloy. • We covered the explanation of incommensurability and noncollinearity of ScFe{sub 4}Al{sub 8}. • We discussed the magnetism resulting from competitiveness of exchange effects.

  19. Cosmogenic {sup 45}Sc in Gibeon iron meteorite by radioanalytical neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Oura, Y. [Tokyo Metropolitan Univ., Hachioji (Japan). Dept. of Chemistry; Honda, M. [Nihon Univ., Tokyo (Japan). Dept. of Chemistry; Ebihara, M.; Bajo, K.; Nagao, K. [Tokyo Univ., Hongo (Japan). Geochemical Research Center

    2011-07-01

    Cosmogenic nuclides in many fragments of Gibeon iron meteorite have been studied by Honda and coworkers. They observed that their concentrations varied by 5 orders and found that Gibeon gives two different exposure ages using pair of stable noble gas isotopes and radinuclide. To assess one possible cause for the difference, namely loss of partial noble gases due to atmospheric heating of the incoming meteoroid, concentrations of non-volatile and stable cosmogenic {sup 45}Sc of Gibeon were determined by radiochemical neutron activation analysis (RNAA). For RNAA, a radiochemical procedure using extraction chromatography was developed to separate Sc from an iron meteorite. Concentrations of {sup 45}Sc in 7 fragments ranged from 0.0064 to 0.11 ppb and correlated with cosmogenic {sup 4}He concentrations. This correlation suggests that noble gases in Gibeon were not lost during the fall to the earth. (orig.)

  20. Far infrared properties of the rare-earth scandate DyScO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Baldassarre, L; Perucchi, A [Sincrotrone Trieste S C p A, S S 14 km 163.5, in Area Science Park, 34012 Basovizza, Trieste (Italy); Lupi, S [CNR-IOM and Dipartimento di Fisica, Universita di Roma Sapienza, Piazzale Aldo Moro 2, 00185 Rome (Italy); Dore, P, E-mail: leonetta.baldassarre@elettra.trieste.i [CNR-SPIN and Dipartimento di Fisica, Universita di Roma ' Sapienza, Piazzale Aldo Moro 2, 00185 Rome (Italy)

    2010-09-08

    We present reflectance measurements in the infrared region on a single crystal the rare-earth scandate DyScO{sub 3}. Measurements performed between room temperature and 10 K allow us to determine the frequency of the infrared-active phonons, never investigated experimentally, and to get information on their temperature dependence. A comparison with the phonon peak frequency resulting from ab initio computations is also provided. We finally report detailed data on the frequency dependence of the complex refractive index of DyScO{sub 3} in the terahertz region, which is important in the analysis of terahertz measurements on thin films deposited on DyScO{sub 3}.

  1. Sc3CH@C80: selective (13)C enrichment of the central carbon atom.

    Science.gov (United States)

    Junghans, Katrin; Rosenkranz, Marco; Popov, Alexey A

    2016-05-01

    Sc3CH@C80 is synthesized and characterized by (1)H, (13)C, and (45)Sc NMR. A large negative chemical shift of the proton, -11.73 ppm in the Ih and -8.79 ppm in the D5h C80 cage isomers, is found. (13)C satellites in the (1)H NMR spectrum enabled indirect determination of the (13)C chemical shift for the central carbon at 173 ± 1 ppm. Intensity of the satellites allowed determination of the (13)C content for the central carbon atom. This unique possibility is applied to analyze the cluster/cage (13)C distribution in mechanistic studies employing either (13)CH4 or (13)C powder to enrich Sc3CH@C80 with (13)C. PMID:27109443

  2. Laboratory oscillator strengths of Sc I in the near-infrared region for astrophysical applications

    CERN Document Server

    Pehlivan, A; Hartman, H

    2015-01-01

    Context. Atomic data is crucial for astrophysical investigations. To understand the formation and evolution of stars, we need to analyse their observed spectra. Analysing a spectrum of a star requires information about the properties of atomic lines, such as wavelengths and oscillator strengths. However, atomic data of some elements are scarce, particularly in the infrared region, and this paper is part of an effort to improve the situation on near-IR atomic data. Aims. This paper investigates the spectrum of neutral scandium, Sc i, from laboratory measurements and improves the atomic data of Sc i lines in the infrared region covering lines in R, I, J, and K bands. Especially, we focus on measuring oscillator strengths for Sc i lines connecting the levels with 4p and 4s configurations. Methods. We combined experimental branching fractions with radiative lifetimes from the literature to derive oscillator strengths (f - values). Intensity-calibrated spectra with high spectral resolution were recorded with Fouri...

  3. Comparison of Response between RC and SC Containment Structures Subjected to Aircraft Impact

    International Nuclear Information System (INIS)

    Since the aircraft terror to the World Trade Center (WTC) on September 11, 2001, an aircraft impact problem has been increasingly interested. The possibilities of aircraft impacts against nuclear power plants are one of important category. To date, the impact load of the analysis on aircraft impacts has been applied to target structures in local areas by using the impact force-time history function of Riera. However, Riera forcing function is not recommended at the expectation of unreasonable damage or perforation to target structures. The numerical analysis of rc and sc containment structures subjected to aircraft impact is performed by using the AUTODYN-3D. It is carried out the four different types for RC and SC structures. Thus, in this study, the different behaviors of containment structures and the safety of SC structure are expected

  4. Preliminary Analysis of the Social and Scientific Impact of the UAEM-ININ M.Sc. and D.Sc. Graduate Programme in Medical Physics

    Science.gov (United States)

    Mitsoura, Eleni; Isaac-Olive, Keila; Torres-Garcia, Eugenio; Camacho-Lopez, Miguel Angel; Hardy-Perez, Alberto

    2010-12-01

    Sponsored by the International Atomic Energy Agency (IAEA) in 1994, the Instituto Nacional de Investigaciones Nucleares (ININ) started in Mexico a teaching and training programme (Diplomado) in Radiotherapy Medical Physics. Based on this experience, the Universidad Autónoma del Estado de México (UAEM) and the Instituto Nacional de Investigaciones Nucleares (ININ) launched two years later, the first Graduate Programme in Science (M.Sc. and D.Sc.), specialised in Medical Physics in Mexico. A preliminary analysis of the social and scientific impact of the UAEM-ININ Programme is presented in this work based on the achievements attained, regarding the number of graduated Medical Physicists, their geographic and academic origin, their current professional activities and the number of scientific publications produced as a result of the thesis, as well as their citations.

  5. Enhanced hardness in epitaxial TiAlScN alloy thin films and rocksalt TiN/(Al,Sc)N superlattices

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Bivas [School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); Lawrence, Samantha K.; Bahr, David F. [School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Schroeder, Jeremy L.; Birch, Jens [Thin Film Physics Division, Department of Physics, Chemistry, and Biology (IFM), Linköping University, SE-581 83 Linköping (Sweden); Sands, Timothy D. [School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 (United States)

    2014-10-13

    High hardness TiAlN alloys for wear-resistant coatings exhibit limited lifetimes at elevated temperatures due to a cubic-AlN to hexagonal-AlN phase transformation that leads to decreasing hardness. We enhance the hardness (up to 46 GPa) and maximum operating temperature (up to 1050 °C) of TiAlN-based coatings by alloying with scandium nitride to form both an epitaxial TiAlScN alloy film and epitaxial rocksalt TiN/(Al,Sc)N superlattices on MgO substrates. The superlattice hardness increases with decreasing period thickness, which is understood by the Orowan bowing mechanism of the confined layer slip model. These results make them worthy of additional research for industrial coating applications.

  6. The first principle study of Ni2ScGa and Ni2TiGa

    International Nuclear Information System (INIS)

    We computed the electronic structure, elastic moduli, vibrational properties, and Ni2TiGa and Ni2ScGa alloys in the cubic L21 structure. The obtained equilibrium lattice constants of these alloys are in good agreement with available data. In cubic systems, there are three independent elastic constants, namely C11, C12 and C44. We calculated elastic constants in L21 structure for Ni2TiGa and Ni2ScGa using the energy-strain method. The electronic band structure, total and partial density of states for these alloys were investigated within density functional theory using the plane-wave pseudopotential method implemented in Quantum-Espresso program package. From band structure, total and projected density of states, we observed metallic characters of these compounds. The electronic calculation indicate that the predominant contributions of the density of states at Fermi level come from the Ni 3d states and Sc 3d states for Ni2TiGa, Ni 3d states and Sc 3d states for Ni2ScGa. The computed density of states at Fermi energy are 2.22 states/eV Cell for Ni2TiGa, 0.76 states/eV Cell for Ni2ScGa. The vibrational properties were obtained using a linear response in the framework at the density functional perturbation theory. For the alloys, the results show that the L21 phase is unstable since the phonon calculations have imagine modes

  7. 47Ca production for 47Ca/47Sc generator system using electron linacs

    International Nuclear Information System (INIS)

    In this work we have studied the feasibility of photonuclear production of 47Ca from 48Ca for 47Ca/47Sc generators. Photon flux distribution for electron beams of different energies incident on a tungsten converter was calculated using the MCNPX radiation transport code. The 47Ca production rate dependence on electron beam energy was found and 47Ca/47Sc yields were estimated for a 40 MeV electron beam. It was shown that irradiating enriched targets with a 40 MeV, 1 mA beam will result in tens of MBq g−1 (few mCi g−1) activity of 47Sc. The results of the simulations were benchmarked by irradiating 22.5 g of CaCl2 powder with a 39 MeV electron beam incident on a tungsten converter. Measured 47Ca/47Sc activities were found to be in very good agreement with the predictions. - Highlights: • We have evaluated the 47Ca production rate using 48Ca(γ,n)47Ca reaction for different electron beam energies and have constructed “parent”-“daughter” activity curves to estimate 47Sc yields. • We have shown the advantages of irradiating a 48Ca target in comparison to natural calcium target • To verify the predicted yield values we have irradiated 22.5 g of calcium chloride (natCaCl2) powder using 39 MeV, 12.5 μA electron beam and found the results to be in a good agreement with the simulations • We have shown that irradiating a 48Ca target with a 40 MeV 1 mA beam will result in tens of MBq g−1 (~ mCi g−1) activity of 47Sc

  8. Thermal neutron capture and resonance integral cross sections of 45Sc

    Science.gov (United States)

    Van Do, Nguyen; Duc Khue, Pham; Tien Thanh, Kim; Thi Hien, Nguyen; Kim, Guinyun; Kim, Kwangsoo; Shin, Sung-Gyun; Cho, Moo-Hyun; Lee, Manwoo

    2015-11-01

    The thermal neutron cross section (σ0) and resonance integral (I0) of the 45Sc(n,γ)46Sc reaction have been measured relative to that of the 197Au(n,γ)198Au reaction by means of the activation method. High-purity natural scandium and gold foils without and with a cadmium cover of 0.5 mm thickness were irradiated with moderated pulsed neutrons produced from the Pohang Neutron Facility (PNF). The induced activities in the activated foils were measured with a high purity germanium (HPGe) detector. In order to improve the accuracy of the experimental results the counting losses caused by the thermal (Gth) and resonance (Gepi) neutron self-shielding, the γ-ray attenuation (Fg) and the true γ-ray coincidence summing effects were made. In addition, the effect of non-ideal epithermal spectrum was also taken into account by determining the neutron spectrum shape factor (α). The thermal neutron cross-section and resonance integral of the 45Sc(n,γ)46Sc reaction have been determined relative to the reference values of the 197Au(n,γ)198Au reaction, with σo,Au = 98.65 ± 0.09 barn and Io,Au = 1550 ± 28 barn. The present thermal neutron cross section has been determined to be σo,Sc = 27.5 ± 0.8 barn. According to the definition of cadmium cut-off energy at 0.55 eV, the present resonance integral cross section has been determined to be Io,Sc = 12.4 ± 0.7 barn. The present results are compared with literature values and discussed.

  9. Electronic and optical properties of ZnSc2S4 and CdSc2S4 cubic spinels by the modified Becke-Johnson density functional

    Science.gov (United States)

    Bouhemadou, A.; Al-Essa, S.; Allali, D.; Ghebouli, M. A.; Bin-Omran, S.

    2013-06-01

    Structural, electronic and optical properties of the ZnSc2S4 and CdSc2S4 cubic spinels have been investigated by means of the full-potential (linearized) augmented plane wave plus local orbitals based on density functional theory. The exchange-correlation potential is treated by the GGA-PBEsol [J.P. Perdew, A. Ruzsinszky, G.I. Csonka, O.A. Vydrov, G.E. Scuseria, L.A. Constantin, X. Zhou, K. Burke, Phys. Rev. Lett. 100 (2008) 136406] and the recently proposed modified Becke-Johnson potential approximation (mBJ) [F. Tran, P. Blaha, Phys. Rev. Lett. 102 (2009) 226401], which successfully corrects the band-gap problem found with GGA for a wide range of materials. The obtained structural parameters are in good agreement with the available experimental data. This gives support for the predict properties for ZnSc2S4 and CdSc2S4. The band structures reveal that both compounds are semiconductor with a direct gap. The obtained gap values show that mBJ is superior for estimating band gap energy. We have calculated the electron and hole effective masses in different directions. The density of states has been analyzed. Based on our electronic structure obtained using the mBJ method we have calculated various optical properties, including the complex dielectric function ɛ(ω), complex index of refraction n(ω), reflectivity coefficient R(ω), absorption coefficient α(ω) and electron energy-loss function L(ω) as functions of the photon energy. We find that the values of zero-frequency limit ɛ1(0) increase with decreasing the energy band gap in agreement with the Penn model. The origin of the peaks and structures in the optical spectra is determined in terms of the calculated energy band structures.

  10. Preparation, microstructure and properties of Al-Zn-Mg-Sc alloy tubes

    Institute of Scientific and Technical Information of China (English)

    何振波; 尹志民; 林森; 邓英; 商宝川; 周向

    2010-01-01

    The Al-6.0Zn-2.0Mg-0.2Sc-0.10Zr hollow tube ingots, prepared by semi-continuous casting technology, were subjected to ho- mogenization treatment, hot extrusion, intermediate annealing, tension, solution and aging treatment. The microstructures and properties of as-cast Al-Zn-Mg-Sc alloy at different homogenization treatment conditions were studied using hardness measurement, X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The results showed th...

  11. Optimization of ScCO2 Extraction of Rambutan Seed Oil Using Response Surface Methodology

    OpenAIRE

    Nuttawan Yoswathana

    2013-01-01

    Seed of rambutan as a waste of products from the canned fruit industry and was extracted by supercritical carbon dioxide (ScCO2) using CO2 as a solvent, maceration and soxhlet extraction using ethanol as the solvent. An optimization study of ScCO2 extraction using response surface methodology was performed and 3D response surfaces were plotted from the mathematical models. The optimal conditions based on combination responses were: pressure (X1) at 34.8 MPa, temperature (X2) at 56.7oC, the am...

  12. Electrical characterization of high-pressure reactive sputtered ScOx films on silicon

    International Nuclear Information System (INIS)

    Al/ScOx/SiNx/n-Si and Al/ScOx/SiOx/n-Si metal-insulator-semiconductor capacitors have been electrically characterized. Scandium oxide was grown by high-pressure sputtering on different substrates to study the dielectric/insulator interface quality. The substrates were silicon nitride and native silicon oxide. The use of a silicon nitride interfacial layer between the silicon substrate and the scandium oxide layer improves interface quality, as interfacial state density and defect density inside the insulator are decreased.

  13. On measuring the UNK SC-dipole bending strength with rotating pick-up coil

    International Nuclear Information System (INIS)

    The experience in measuring the SC-dipole bending strength with the spotting method shown this measurement to be the most complicated and expensive. A convenient and simple method of rotating pick-up coil, which can not provide the required accuracy, may be used for this measurement combined with NMR measurements in the dipole central part. The physical ground and description of the method are given in the paper. The analysis of the errors and measurement results of the SPDMI SC-dipoles are presented. 9 refs..; 7 figs

  14. High-pressure study of substrate material ScAlMgO4

    OpenAIRE

    Errandonea, D.; R. S. Kumar; Ruiz-Fuertes, J.; Segura, A.; Haussuehl, E.

    2011-01-01

    We report on the structural properties of ScAlMgO4 studied under quasi-hydrostatic pressure using synchrotron high-pressure x-ray diffraction up to 40 GPa. We also report on single-crystal studies of ScAlMgO4 performed at 300 K and 100 K. We found that the low-pressure phase remains stable up to 24 GPa. At 28 GPa, we detected a reversible phase transformation. The high-pressure phase is assigned to a monoclinic distortion of the low-pressure phase. No additional phase transition is observed u...

  15. Hot fusion-evaporation cross sections of 45Sc -induced reactions with lanthanide targets

    Science.gov (United States)

    Werke, T. A.; Mayorov, D. A.; Alfonso, M. C.; Bennett, M. E.; DeVanzo, M. J.; Frey, M. M.; Tereshatov, E. E.; Folden, C. M.

    2015-09-01

    Background: 45Sc has rarely been studied as a projectile in fusion-evaporation reactions. The synthesis of new superheavy elements with Z >118 will require projectiles with Z >20 , and 45Sc could potentially be used for this purpose. Purpose: Cross sections were measured for the x n and p x n exit channels in the reactions of 45Sc with lanthanide targets for comparison to previous measurements of 48Ca reacting with similar targets. These data provide insight on the survival of spherical, shell-stabilized nuclei against fission, and could have implications for the discovery of new superheavy elements. Methods: Beams of 45Sc6 + were delivered from the K500 superconducting cyclotron at Texas A&M University with an energy of ≈5 MeV /nucleon . Products were purified using the Momentum Achromat Recoil Spectrometer, and excitation functions were measured for reactions of 45Sc+156-158,160Gd, 159Tb , and 162Dy at five or more energies each. Evaporation residues were identified by their characteristic α -decay energies. Experimental data were compared to a simple theoretical model to study each step in the fusion-evaporation process. Results: The maximum measured 4 n cross sections for the reactions 45Sc+156-158,160Gd, 159Tb , and 162Dy are 5.8 ±1.7 , 25 ±5 , 39 ±7 , 150 ±20 , 2 .4-1.4+2.3 , and 1.8 ±0.6 μ b , respectively. Proton emission competes effectively with neutron emission from the excited compound nucleus in most cases. The α ,α n , and α 2 n products were also observed in the 45Sc+162Dy reaction. Conclusions: Excitation functions were reported for 45Sc -induced reactions on lanthanide targets for the first time, and these cross sections are much smaller than for 48Ca -induced reactions on the same targets. The relative neutron-deficiency of the compound nuclei leads to significantly increased fissility and large reductions in the survival probability. Little evidence for improved production cross sections due to shell-stabilization was observed.

  16. Site preference and vibrational properties of ScFexAl12-x

    International Nuclear Information System (INIS)

    The site preference of Fe in ScFexAl12-x is studied using the interatomic potentials. These potentials between the identical and distinct atoms are obtained by a strict lattice inversion method. The lattice constants of ScFexAl12-x with different x are calculated, which are in good agreement with the experiments. This work presents the phonon densities of states of these ternary intermetallic compounds with ThMn12-type structure. A qualitative analysis is carried out with the relevant potentials for the vibrational modes, which makes it possible to predict some properties related to lattice vibration

  17. Health physics experience during 46Sc radiotracer injection at Kolkata Port, Kolkata

    International Nuclear Information System (INIS)

    To examine the suitability of dumping site for dredged sediment, 46Sc in scandium glass matrix is mainly used for the investigation at ports and harbours. In this paper authors share Health Physics experience on control of personnel exposure in order to achieve ALARA. About 260 GBq of 46Sc was used for sediment transport study near SAGAR Island at Kolkata Port, Kolkata. During the study, the maximum dose was found to be less than 0.37 mSv, which is 1.23 % of the authorized annual effective dose limits for occupational radiation worker. The average dose for the experiment was computed as 0.21 mSv. (author)

  18. Observation of coexistence of ferroelectric and antiferroelectric phases in Sc substituted BiFeO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Durga Rao, T.; Asthana, Saket, E-mail: asthanas@iith.ac.in; Niranjan, Manish K.

    2015-09-05

    Highlights: • Coexisting ferro- and antiferroelectric phases in Sc substituted compounds. • Structural studies (XRD and Raman) supports the incorporation of Sc at B-site. • Presence of non-centrosymmetric monoclinic phase correlates with AFE ordering. • Grain resistance and activation energies increase with the Sc-content. • Electrical relaxations are originated due to oxygen vacancy movements. - Abstract: Polycrystalline BiFe{sub 1−x}Sc{sub x}O{sub 3} (x = 0, 0.05, 0.10 and 0.15) compounds were prepared using solid state reaction route. The X-ray diffraction patterns showed that Sc substitution stabilized the crystal structure in rhombohedral structure with R3c space group along with nominal percentage of monoclinic structure with Cm space group. Raman and FTIR measurements revealed that the substituent replaced Fe-ions and caused structural distortions. Co-existence of ferroelectric and antiferroelectric phases were observed in Sc substituted BiFeO{sub 3} and antiferroelectric phase is found to be evolved at the expense of ferroelectric phase with the Sc content. The electric field driven effects indicated that antiferroelectric phase was suppressed and ferroelectric phase was enriched. Frequency dependence of dielectric constant (ε{sub r}) and dielectric loss tangent (tan δ) at different temperatures were investigated. Further, grain resistances and grain boundary resistances were increased with the Sc content. Activation energies estimated from dielectric, impedance and modulus data indicated that these relaxations originated presumably due to the oxygen vacancy movements.

  19. Effect of minor Sc and Zr addition on grain refinement of as-cast AI-Zn-Mg-Cu alloys

    Institute of Scientific and Technical Information of China (English)

    He Yongdong; Zhang Xinming; Cao Zhiqiang

    2009-01-01

    The optical microscopy and scanning electron microscopy as well as energy dispersive spectroscopy were employed to investigate the influence of joint addition of Sc and Zr on grain refinement of AI-Zn-Mg-Cu alloys.Results show that the addition of 0.20% Sc has a little effect on grain refinement because Sc is mainly dissolved into the matrix and hardly any primary Al3Sc particles are precipitated. The alloy with addition of 0.30% Sc and 0.16%Zr has more equiaxed grains than that of others,giving cast grain sizes as fine as 13μm. This is because the Sc substitutes for AI atom in the AI-Zr crystal cell and forms AI-Sc-Zr unit cell,which grows and becomes AI3(Scx,Zr1.x)particle,acting as a nucleus for the formation of a-AI. The addition of 0.04% Ti and 0.008% B makes the grain size drop from 250 μm to 50 μm. Its refinement effect is less than the 13 μm achieved by the alloy including 0.30% Sc and 0.16% Zr.

  20. Thermodynamic modeling of the RE–Pb (RE = Sc, Dy, Gd) systems

    International Nuclear Information System (INIS)

    Highlights: • Rare earth (RE) and Pb alloys or compounds are interesting as magnetic materials. • The phase diagrams and thermodynamic properties of RE–Pb (RE = Sc, Dy, Gd) systems have been assessed. • The CALPHAD method was used with the Redlich–Kister model to optimize the solution phases. • A self-consistent set of thermodynamic parameters has been evaluated. • A good agreement was found between the calculation and experiments. -- Abstract: The phase diagrams and thermodynamic properties of RE–Pb (RE = Sc, Dy, Gd) systems have been assessed by means of the CALPHAD method. The solution phases (liquid, fcc, bcc and hcp) were described by the sublattice formalism and the excess term of the Gibbs energy with the Redlich–Kister equation. The stoichiometric intermetallic compounds (Sc5Pb3, Sc6Pb5, Dy5Pb4, DyPb, DyPb2, DyPb3, β-Gd5Pb4, α-Gd5Pb4, Gd11Pb10, Gd6Pb7, GdPb2 and GdPb2) were modeled as line compounds. The non-stoichiometric Dy5Pb3 and Gd5Pb3 phases with a narrow homogeneity range were modeled using a two-sublattice model with substitution. A consistent set of the thermodynamic parameters leading to a reasonable agreement between the calculated results and literature data was obtained

  1. Electron-donor-acceptor fullerene derivative retained on electrods using SC3 hydrophobin

    Czech Academy of Sciences Publication Activity Database

    Corvis, Y.; Trzcinska, K.; Rink, R.; Bílková, Petra; Gorecka, E.; Bilewicz, R.; Rogalska, E.

    2007-01-01

    Roč. 111, č. 3 (2007), s. 1176-1179. ISSN 1932-7447 Grant ostatní: Research Training Network(XE) HPRN-CT-2002-00171; French-Polish bilateral project Polonium(XE) 09184SC Institutional research plan: CEZ:AV0Z10100520 Keywords : fullerene * photovoltaic device * immobilization * cyclic voltammetry * electrochemistry Subject RIV: BM - Solid Matter Physics ; Magnetism

  2. Pressure-induced structural transformations in the molybdate Sc-2(MoO4)(3)

    DEFF Research Database (Denmark)

    Paraguassu, W.; Maczka, M.; Filho, A. G. Sonza; Freire, P. T. L.; Filho, J. M.; Melo, F. E. A.; Macalik, L.; Gerward, Leif; Olsen, J. Staun; Waskowska, A.; Hanuza, J.

    2004-01-01

    . The crystal to amorphous transition is irreversible. Our results point out that the amorphization process in Sc-2(MoO4)(3) may be due to a kinetic hindrance of a phase transition rather than due to chemical decomposition effects as have been proposed to occur for some molybdates and tungstates....

  3. SC-FDE for MMF short reach optical interconnects using directly modulated 850 nm VCSELs

    DEFF Research Database (Denmark)

    Teichmann, Victor S. C.; Barreto, Andre N.; Pham, Tien Thang;

    2012-01-01

    We propose the use of single-carrier frequency-domain equalization (SC-FDE) for the compensation of modal dispersion in short distance optical links using multimode fibers and 850 nm VCSELs. By post-processing of experimental data, we demonstrate, at 7.9% overhead, the error-free transmission (over...

  4. Thermography of semi-transparent materials by a FLIR ThermaCAM SC3000 infrared camera

    NARCIS (Netherlands)

    Van der Tempel, L.

    2011-01-01

    An acceptance test for thermography of semi-transparent materials by a FLIR ThermaCAM SC3000 infrared camera with 8.0 µm low-wavelength-pass filter has been developed and performed on polycarbonate, PEN, quartz, Corning 1737 glass, G427 cone glas, G443 screen glass, Schott Zerodur, silicon and a bl

  5. Implementation of LTE SC-FDMA on the USRP2 Software Defined Radio Platform

    DEFF Research Database (Denmark)

    Jørgensen, Peter Bjørn; Hansen, Thomas Lundgaard; Sørensen, Troels Bundgaard;

    2011-01-01

    ) standard. In this paper we derive a AWGN channel model for SC-FDMA transmission, which is useful for benchmarking experimental results. In our implementation, we deal with signal scaling, qualization and partial synchronization to realize SCFDMA transmission over a noisy channel at rates up to 5.184 Mbit...

  6. UAS Integration in the NAS Project Overview: RTCA SC-228 Plenary DAA Working Group 5

    Science.gov (United States)

    Randall, Debra K.

    2014-01-01

    The presentation is intended to allow the public to know and understand NASA's plans for integrated test to allow them the opportunity to provide feedback and suggestions. The integrated testing will support verification and validation of the RTCA SC-228 UAS minimum operation performance standard requirements.

  7. 44gSc from metal calcium targets for PET

    DEFF Research Database (Denmark)

    Severin, Gregory; Gagnon, K.; Engle, J. W.;

    2012-01-01

    A low-cost and efficient method for producing pre-clinical scale quantities of 44gSc is presented. Production involves proton irradiation of natural unenriched calcium metal followed by rapid separation of radioscandium from the target using hydroxmate functionalized resin.© 2012 American Institu...

  8. Biogas Upgrading Using SOEC with a Ni-ScYSZ Electrode

    DEFF Research Database (Denmark)

    Ebbesen, Sune Dalgaard; Bøgild Hansen, John; Mogensen, Mogens Bjerg

    2013-01-01

    Biogas consists mainly of CH4, CO2 and small amounts of H2S. The value of biogas will increase significantly if it is upgraded to pipeline quality by converting CO2 and H2O in the biogas to CO and H2 using a Solid Oxide Electrolysis Cell (SOEC) followed by methanation. The Ni-ScYSZ-cermet electrode...

  9. Comparison of the texture evolution in cold rolled DC and SC AA 5182 aluminum alloys

    International Nuclear Information System (INIS)

    The hot bands of direct chill cast (DC) and strip cast (SC) AA 5182 aluminum alloys were annealed at 454 deg. C for 3 h, and then cold rolled to different reductions. The ODFs of the cold rolled samples were determined by X-ray diffraction in order to compare the texture evolution of DC and SC AA 5182 aluminum alloys during rolling. The texture volume fractions were computed by a new method, in which the Euler space representing all possible crystallographic orientations in rolling was subdivided into the cube, r-cube, Goss, r-Goss, β fiber, and random orientation regions based on the slip pattern combined with the characteristics of microstructure and texture. Empirical formulae of the texture volume fractions and true strain were constructed to predict the texture of cold rolled DC and SC AA 5182 aluminum alloys. The results show that the processing method (DC vs. SC) strongly affects the texture after annealing at 454 deg. C and the texture evolution during the subsequent rolling

  10. 76 FR 79571 - Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC

    Science.gov (United States)

    2011-12-22

    ... the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to..., Ashley River, Charleston, SC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY... regulations consist of a series of moving buffer zones around participant vessels as they transit the...

  11. Fermilab's SC Accelerator Magnet Program for Future U.S. HEP Facilities

    International Nuclear Information System (INIS)

    The invention of SC accelerator magnets in the 1970s opened wide the possibilities for advancing the energy frontier of particle accelerators, while limiting the machine circumference and reducing their energy consumption. The successful development of SC accelerator magnets based on NbTi superconductor have made possible a proton-antiproton collider (Tevatron) at Fermilab, an electron-proton collider (HERA) at DESY, a relativistic heavy ion collider (RHIC) at BNL and recently a proton-proton collider (LHC) at CERN. Further technological innovations and inventions are required as the US HEP looks forward towards the post-LHC energy or/and intensity frontiers. A strong, goal oriented national SC accelerator magnet program must take on this challenge to provide a strong base for the future of HEP in the U.S. The results and experience obtained by Fermilab during the past 30 years will allow us to play a leadership role in the SC accelerator magnet development in the U.S., in particular, focusing on magnets for a Muon Collider/Neutrino Factory (1)-(2). In this paper, we summarize the required Muon Collider magnet needs and challenges, summarize the technology advances in the Fermilab accelerator magnet development over the past few years, and present and discuss our vision and long-term plans for these Fermilab-supported accelerator initiatives.

  12. 77 FR 59451 - Pickens Railway Company-Abandonment Exemption-in Pickens County, SC

    Science.gov (United States)

    2012-09-27

    ... Surface Transportation Board Pickens Railway Company--Abandonment Exemption--in Pickens County, SC Pickens Railway Company (Pickens) has filed a verified notice of exemption under 49 CFR part 1152 subpart F... the effects, if any, of the abandonment on the environment and historic resources. OEA will issue...

  13. Insilico analysis of three different tag polypeptides with dual roles in scFv antibodies.

    Science.gov (United States)

    Mohammadi, Mozafar; Nejatollahi, Foroogh; Sakhteman, Amirhossein; Zarei, Neda

    2016-08-01

    Single chain fragment variable (scFv) antibodies are composed of variable heavy (VH) and variable light (VL) domains that are joined by a polypeptide linker. Typically, [(Gly4Ser) n] sequence is used as a linker to retain the integrity of the antigen-binding domain. Due to its low immunogenicity, this sequence cannot be used as a tag for scFv detection and purification. Several evidences have shown that the addition of an N or C-terminal tag for scFv detection and purification will result in the decreased expression and binding capacity of this antibody fragment. In this study, we substituted the traditional linker (GGGGS) with His-tag, C-myc or E-tag sequences through molecular modeling. Stability and integrity of all models were assessed by molecular dynamic (MD) simulation. Based on MD simulation analysis, the model containing E-tag sequence as a linker indicated more stability compared to other molecules. The results suggest that E-tag not only can be substituted for the traditional linker, also eliminates the necessity of using additional tag for scFv detection and purification. PMID:27113782

  14. Three-phase-boundary dynamics at the Ni/ScYSZ interface

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hansen, Karin Vels; Norrman, Kion; Mogensen, Mogens Bjerg

    Chronoamperometry using a three-electrode cell configuration was undertaken with a nickel point-electrode acting as the working electrode on a polished ScYSZ electrolyte in a hydrogen atmosphere at 750–850 °C. High anodic overpotentials resulted in the occurrence of distinct sawtooth oscillation...

  15. Radioiodination and biodistribution of the monoclonal antibody TU-20 and its scFv fragment

    Czech Academy of Sciences Publication Activity Database

    Kleinová, Veronika; Chaloupková, H.; Švecová, Helena; Fišer, Miroslav

    2010-01-01

    Roč. 286, č. 3 (2010), s. 847-851. ISSN 0236-5731 R&D Projects: GA AV ČR IBS1048301 Institutional research plan: CEZ:AV0Z10480505 Keywords : Monoclonal antibody TU-20 * ScFv TU-20 * Radiolabeling Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 0.777, year: 2010

  16. Performance Evaluation of the IBM SP and the Compaq AlphaServer SC

    International Nuclear Information System (INIS)

    Oak Ridge National Laboratory (ORNL) has recently installed both a Compaq AlphaServer SC and an IBM SP, each with 4-way SMP nodes, allowing a direct comparison of the two architectures. In this paper, we describe our initial evaluation. The evaluation looks at both kernel and application performance for a spectral atmospheric general circulation model, an important application for the ORNL systems

  17. 75 FR 34170 - Plastic Omnium Automotive Exteriors, LLC, Anderson, SC; Plastic Omnium Automotive Exteriors, LLC...

    Science.gov (United States)

    2010-06-16

    ..., South Carolina. The notice was published in the Federal Register April 23, 2010 (75 FR 21356). The... Employment and Training Administration Plastic Omnium Automotive Exteriors, LLC, Anderson, SC; Plastic Omnium Automotive Exteriors, LLC, Troy, MI; Amended Certification Regarding Eligibility To Apply for...

  18. Effect of homogenization treatment on microstructure and properties of Al-Mg-Mn-Sc-Zr alloy

    Institute of Scientific and Technical Information of China (English)

    NIE Bo; YIN Zhi-min; ZHU Da-peng; PENG Yong-yi; JIANG Feng; HUANG Ji-wu

    2007-01-01

    The effect of homogenization on the hardness, tensile properties, electrical conductivity and microstructure of as-cast Al-6Mg-0.4Mn-0.25Sc-0.12Zr alloy was studied. The results show that during homogenization as-cast studied alloy has obviously hardening effect that is similar to aging hardening behavior in traditional Al alloys. The precipitates are mainly Al3(Sc,Zr) and Al6Mn.When homogenization temperature increases the hardness peak value is declined and the time corresponding to hardness peak value is shortened. The electrical conductivity of the alloy monotonously increases with increasing homogenization temperature and time.The decomposition of the supersaturated solid solution containing Sc and Zr which is formed during direct chilling casting and the precipitation of Al3(Sc, Zr) cause hardness increasing. The depletion of the matrix solid solubility decreases the ability of electron scattering in the alloy, resulting in the electrical conductivity increased. Tensile property result at hot rolling state shows that the optimal homogenization treatment processing is holding at 300-350 ℃ for 6-8 h.

  19. Anomalously high thermoelectric power factor in epitaxial ScN thin films

    DEFF Research Database (Denmark)

    Kerdsongpanya, Sit; Van Nong, Ngo; Pryds, Nini;

    2011-01-01

    Thermoelectric properties of ScN thin films grown by reactive magnetron sputtering on Al2O3(0001) wafers are reported. X-ray diffraction and elastic recoil detection analyses show that the composition of the films is close to stoichiometry with trace amounts (∼1 at. % in total) of C, O, and F. We...

  20. CERN Technical Training 2004: New Short Course III (SC III) on Microsoft Outlook - Meetings and Delegation

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled session of the 3rd module will take place as follows: Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14:00-16:00) SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she will be available some time after each session to answer specific questions, or provide further explanations following demand. The cost of attending any SC module on Outlook is 70.- CHF. The above session will be confirmed if there are enough participants, and the attendance costs will be lower in case of a full class. If you are interested in...

  1. Prevention of Cyberbullying and Cyber Victimization: Evaluation of the ViSC Social Competence Program

    Science.gov (United States)

    Gradinger, Petra; Yanagida, Takuya; Strohmeier, Dagmar; Spiel, Christiane

    2015-01-01

    It is well-documented that cyberbullying and victimization co-occur with traditional forms indicating that they share similar mechanisms. Therefore, it was hypothesized that the general antibullying program ViSC might also be effective in tackling these new forms of bullying. A longitudinal randomized control group design has been applied to…

  2. Ultrasonic determination of anisotropic elasticity of DyScO3 substrates

    Czech Academy of Sciences Publication Activity Database

    Seiner, Hanuš; Sedlák, Petr; Janovská, Michaela; Landa, Michal; Márton, Pavel; Ondrejkovič, Petr; Hlinka, Jiří

    Praha, 2013. [Joint UFFC, EFTF and PFM Symposium 2013. 21.07.2013-25.07.2013, Praha] Institutional support: RVO:68378271 ; RVO:61388998 Keywords : anisotropic elasticity * DyScO3 substrates * resonant ultrasound spectroscopy (RUS) Subject RIV: BI - Acoustics; BI - Acoustics (FZU-D)

  3. 77 FR 74472 - Application to Export Electric Energy; Energia Renovable S.C., LLC

    Science.gov (United States)

    2012-12-14

    ... Application to Export Electric Energy; Energia Renovable S.C., LLC AGENCY: Office of Electricity Delivery and... Renovable) has applied for authority to transmit electric energy from the United States to Mexico pursuant... application from Energia Renovable for authority to transmit electric energy from the United States to...

  4. Change in work function during phase transition of Sc-O/W(1 0 0) system at high temperatures

    International Nuclear Information System (INIS)

    The change in work function during the phase transition of a Sc-O/W(1 0 0) system at high temperatures of 1500-1700 K was investigated in order to elucidate the mechanism of the decrease in the work function of a (1 x 1)-Sc-O/W(1 0 0) surface. For the measurement of the work function using a secondary electron method at high temperatures, a sample holder was uniquely designed in order to suppress contributions of a large number of thermionic electrons emitted from a low-work-function surface. The obtained work function revealed that the change in work function strongly correlates with the coverage of Sc-O complexes, the stoichiometry of which is Sc1O1. The higher the coverage of ScO is, the lower the work function is, suggesting that the work function of the (1 x 1)-Sc-O/W(1 0 0) surface is reduced by the formation of ScO electric dipoles. Furthermore, the decrease in work function was modeled in combination with a previously reported kinetic model describing surface phenomena, i.e., the oxidation, oxygen desorption, diffusion and surface segregation of Sc-O complexes, during the phase transition of the Sc-O/W(1 0 0) surface at high temperatures. It was confirmed that the proposed model can explain the experimentally obtained change in work function very well. The value of the dipole moment of a ScO electric dipole was determined to be 2.7 x 10-30 C m.

  5. In vivo imaging of prostate cancer using an anti-PSMA scFv fragment as a probe.

    Science.gov (United States)

    Mazzocco, Claire; Fracasso, Giulio; Germain-Genevois, Coralie; Dugot-Senant, Nathalie; Figini, Mariangela; Colombatti, Marco; Grenier, Nicolas; Couillaud, Franck

    2016-01-01

    We aimed to evaluate a fluorescent-labeled single chain variable fragment (scFv) of the anti-PSMA antibody as a specific probe for the detection of prostate cancer by in vivo fluorescence imaging. An orthotopic model of prostate cancer was generated by injecting LNCaP cells into the prostate lobe. ScFvD2B, a high affinity anti-PSMA antibody fragment, was labeled using a near-infrared fluorophore to generate a specific imaging probe (X770-scFvD2B). PSMA-unrelated scFv-X770 was used as a control. Probes were injected intravenously into mice with prostate tumors and fluorescence was monitored in vivo by fluorescence molecular tomography (FMT). In vitro assays showed that X770-scFvD2B specifically bound to PSMA and was internalized in PSMA-expressing LNCaP cells. After intravenous injection, X770-scFvD2B was detected in vivo by FMT in the prostate region. On excised prostates the scFv probe co-localized with the cancer cells and was found in PSMA-expressing cells. The PSMA-unrelated scFv used as a control did not label the prostate cancer cells. Our data demonstrate that scFvD2B is a high affinity contrast agent for in vivo detection of PSMA-expressing cells in the prostate. NIR-labeled scFvD2B could thus be further developed as a clinical probe for imaging-guided targeted biopsies. PMID:26996325

  6. Production, purification, and characterization of human scFv antibodies expressed in Saccharomyces cerevisiae, Pichia pastoris, and Escherichia coli.

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Keith D.; Feldhaus, Jane M.; Gray, Sean A.; Siegel, Robert W.; Feldhaus, Michael J.

    2005-08-01

    Single chain (scFv) antibodies are used as affinity reagents for diagnostics, therapeutics, and proteomic analyses. The antibody discovery platform we use to identify novel antigen binders involves discovery, characterization, and production. The discovery and characterization components have previously been characterized but in order to fully utilize the capabilities of affinity reagents from our yeast surface display library, efforts were focused on developing a production component to obtain purified, soluble, and active scFvs. Instead of optimizing conditions to achieve maximum yield, efforts were focused on using a system that could quickly and easily produce and process hundreds of scFv antibodies. Heterologous protein expression in Saccharomyces cerevisiae, Pichia pastoris, and Escherichia coli were evaluated for their ability to rapidly, efficaciously, and consistently produce scFv antibodies for use in downstream proteomic applications. Following purification, the binding activity of several scFv antibodies were quantified using a novel Biacore assay. All three systems produced soluble scFv antibodies which ranged in activity from 0-99%. scFv antibody yields from Saccharomyces, Pichia, and E. coli were 1.5-4.2, 0.4-7.3, and 0.63-16.4 mg L-1 culture, respectively. For our purposes, expression in E. coli proved to be the quickest and most consistent way to obtain and characterize purified scFv for downstream applications. The E. coli expression system was also used to compare scFv production levels from the periplasm, inclusion bodies, and culture media. The E. coli production system was then used to produce variants of several scFv to determine structure function relationships.

  7. An optimized Fermentation and Purification Process for a Recombinant Human Antibody ScFv-Fc Fragment Expressed in Pichia Pastoris%重组人小分子抗体ScFv-Fc发酵条件的优化及纯化

    Institute of Scientific and Technical Information of China (English)

    王丁丁; 苏曼曼; 胡丽莉; 袁丽颖; 颜炜群

    2011-01-01

    Objective: To obtain an optimized fermentation and purification process for high-level production of a recombinant human antibody ScFv-Fc fragment expression secreted in Pichia pastoris. Methods: The growth conditions of the transformant strain were optimized in 50 ml conical tubes including pH, methanol concentration and inducing time. The ScFv-Fc was purified using a two-step scheme: ammonium sulfate fractionation, protein A Sepharose. Results: ScFv-Fc production was found to increase with 0.5% (v/v) methanol concentration after 72 h induction. Protein production was also greatly affected by pH, resulting in higher yields at 5.2 pH value. The ScFv-Fc was purified more than 94% purity by using protein A Sepharose. Conclusions: The results provided a best process for expression and purification of functional recombinant human monoclonal antibody ScFv-Fc. It suggests a potential use of this antibody generating method by Pichia pastoris and indicates the potential of scFv-Fc fusion proteins as therapeutic candidates.%目的:研究重组人小分子抗体ScFv-Fc在毕赤酵母中分泌表达的最佳条件,以及ScFv-Fc的纯化方法.方法:分别从甲醇浓度、pH、诱导时间等方面对毕赤酵母重组菌株产生ScFv-Fc的发酵过程进行了优化;通过硫酸铵沉淀结合protein A亲和层析柱,对ScFv-Fc的纯化方法进行了研究.结果:确定ScFv-Fc在毕赤酵母中分泌表达的最佳条件为:在pH5.2的条件下,以0.5%甲醇诱导72 h.经过protein A亲和层析柱纯化后,ScFv-Fc纯度可达94%以上.结论:确定了ScFv-Fc在毕赤酵母中分泌表达的最佳条件以及纯化方法,为重组抗体分子诊断、治疗试剂的开发以及抗体的人源化奠定了物质基础.

  8. Recombinant norovirus-specific scFv inhibit virus-like particle binding to cellular ligands

    Directory of Open Access Journals (Sweden)

    Hardy Michele E

    2008-01-01

    Full Text Available Abstract Background Noroviruses cause epidemic outbreaks of gastrointestinal illness in all age-groups. The rapid onset and ease of person-to-person transmission suggest that inhibitors of the initial steps of virus binding to susceptible cells have value in limiting spread and outbreak persistence. We previously generated a monoclonal antibody (mAb 54.6 that blocks binding of recombinant norovirus-like particles (VLP to Caco-2 intestinal cells and inhibits VLP-mediated hemagglutination. In this study, we engineered the antigen binding domains of mAb 54.6 into a single chain variable fragment (scFv and tested whether these scFv could function as cell binding inhibitors, similar to the parent mAb. Results The scFv54.6 construct was engineered to encode the light (VL and heavy (VH variable domains of mAb 54.6 separated by a flexible peptide linker, and this recombinant protein was expressed in Pichia pastoris. Purified scFv54.6 recognized native VLPs by immunoblot, inhibited VLP-mediated hemagglutination, and blocked VLP binding to H carbohydrate antigen expressed on the surface of a CHO cell line stably transfected to express α 1,2-fucosyltransferase. Conclusion scFv54.6 retained the functional properties of the parent mAb with respect to inhibiting norovirus particle interactions with cells. With further engineering into a form deliverable to the gut mucosa, norovirus neutralizing antibodies represent a prophylactic strategy that would be valuable in outbreak settings.

  9. Laboratory oscillator strengths of Sc i in the near-infrared region for astrophysical applications

    Science.gov (United States)

    Pehlivan, A.; Nilsson, H.; Hartman, H.

    2015-10-01

    Context. Atomic data is crucial for astrophysical investigations. To understand the formation and evolution of stars, we need to analyse their observed spectra. Analysing a spectrum of a star requires information about the properties of atomic lines, such as wavelengths and oscillator strengths. However, atomic data of some elements are scarce, particularly in the infrared region, and this paper is part of an effort to improve the situation on near-IR atomic data. Aims: This paper investigates the spectrum of neutral scandium, Sc I, from laboratory measurements and improves the atomic data of Sc I lines in the infrared region covering lines in R, I, J, and K bands. Especially, we focus on measuring oscillator strengths for Sc I lines connecting the levels with 4p and 4s configurations. Methods: We combined experimental branching fractions with radiative lifetimes from the literature to derive oscillator strengths (f-values). Intensity-calibrated spectra with high spectral resolution were recorded with Fourier transform spectrometer from a hollow cathode discharge lamp. The spectra were used to derive accurate oscillator strengths and wavelengths for Sc I lines, with emphasis on the infrared region. Results: This project provides the first set of experimental Sc I lines in the near-infrared region for accurate spectral analysis of astronomical objects. We derived 63 log(gf) values for the lines between 5300 Å and 24 300 Å. The uncertainties in the f-values vary from 5% to 20%. The small uncertainties in our values allow for an increased accuracy in astrophysical abundance determinations.

  10. Ba and BaO on W and on Sc2O3 coated W

    International Nuclear Information System (INIS)

    Temperature-programmed desorption (TPD) and Auger electron spectroscopy (AES) are used to characterize the surface layers that form under an evaporating flux of a dispenser cathode (which is a Ba and BaO source) on a W substrate and Sc2O3-coated W substrate to simulate the surface layer of a conventional dispenser cathode and scandate cathode, respectively. The surface layers were prepared while the substrate was either at 940 deg. Cb (1272 K), a typical operating temperature, or at 1125 deg. Cb (1477 K), a typical activation temperature. Our investigation found that a partial layer of BaO formed on W, similar to the surface layer that forms on a dispenser cathode. Heating to the activation temperature causes the BaO to form a stronger bond with W. For the Sc2O3-coated W substrate, heating to the activation temperature is necessary for the inter-diffusion between the Sc2O3 and W to occur. BaO layers form a stronger bond to the inter-diffused layer than to pure W. However, the most important finding is that a stable BaO-containing compound forms and continues to accumulate under the impinging flux on the Sc2O3 and W covered substrate at 940 deg. Cb. Surface emission models describe successfully all other dispenser cathodes, but fail to explain the emission characteristics of scandate cathodes. Raju and Maloney proposed an alternate model, which requires the presence of a thick layer of semi-conducting material. Our finding suggests that it is possible to form a thick layer from simultaneous presence of BaO, Sc2O3 and W. However, further investigation is necessary to determine if the Raju and Maloney type layer is indeed present on top of scandate cathodes

  11. Ba and BaO on W and on Sc 2O 3 coated W

    Science.gov (United States)

    Shih, A.; Yater, J. E.; Hor, C.

    2005-03-01

    Temperature-programmed desorption (TPD) and Auger electron spectroscopy (AES) are used to characterize the surface layers that form under an evaporating flux of a dispenser cathode (which is a Ba and BaO source) on a W substrate and Sc 2O 3-coated W substrate to simulate the surface layer of a conventional dispenser cathode and scandate cathode, respectively. The surface layers were prepared while the substrate was either at 940 °C b (1272 K), a typical operating temperature, or at 1125 °C b (1477 K), a typical activation temperature. Our investigation found that a partial layer of BaO formed on W, similar to the surface layer that forms on a dispenser cathode. Heating to the activation temperature causes the BaO to form a stronger bond with W. For the Sc 2O 3-coated W substrate, heating to the activation temperature is necessary for the inter-diffusion between the Sc 2O 3 and W to occur. BaO layers form a stronger bond to the inter-diffused layer than to pure W. However, the most important finding is that a stable BaO-containing compound forms and continues to accumulate under the impinging flux on the Sc 2O 3 and W covered substrate at 940 °C b. Surface emission models describe successfully all other dispenser cathodes, but fail to explain the emission characteristics of scandate cathodes. Raju and Maloney proposed an alternate model, which requires the presence of a thick layer of semi-conducting material. Our finding suggests that it is possible to form a thick layer from simultaneous presence of BaO, Sc 2O 3 and W. However, further investigation is necessary to determine if the Raju and Maloney type layer is indeed present on top of scandate cathodes.

  12. Parameterization of the headscatter correction factor Sc for rectangular photon beams Symmetrical and asymmetrical, open and wedged fields

    International Nuclear Information System (INIS)

    In the calculation of monitor units and treatment times of MV photon beams the head scatter factor Sc accounts for the change in photon fluence when the collimator setting and thus the field size is changed. Sc can be measured with a narrow beam-coaxial phantom [1] as a function of the settings of the X and Y collimator blocks. Although Sc is expected to have a symmetrical nature Sc turns out to be an asymmetrical function of these settings. Elongated fields in X and Y directions can have Sc values which differ several per cent. In order to obtain sufficient accuracy usually Sc is measured for a matrix of field sizes of for instance X=2 up to 40 cm and Y=2 up to 40 cm. The reason of this asymmetry originates from the fact that the X and Y blocks are located in different planes. So the aperture - looking upstream from the measurement point to the blocks - is an asymmetrical function of the collimator setting. Our approach is to correct the asymmetry in Sc by considering Sc as a function of the corrected field dimensions either CfX and Y or X and CfY. The factor Cf has a value between 0.0 and 1.0 depending on the beam energy and the accelerator design. An iteration algorithm based on the Clarkson approach is used to calculate a best fit Cf value from Sc values of square and some elongated fields. Effectively the Sc matrix is reduced to a one dimensional function Sc(r), with r the average radius of fields with dimensions X=Cfa and Y=a or X=a and Y=Cfa. The algorithm is applied to calculate Sc of rectangular shaped fields. The accuracy of the method, based on one single - a priori - unknown, parameter Cf is well within measurement accuracy (0.5 %). Besides, a substantial reduction of the number of Sc measurements, necessary to cover the clinically used fields, is achieved this way. The method is validated for symmetrical beams with energies ranging from 6 to 25 MV of accelerators of several manufacturers and also for asymmetrical wedged fields of the 6 MV beams of a

  13. Crystal structures of the ScAgSe{sub 2} and Sc{sub 1.02}Cu{sub 0.54}Sn{sub 1.1}S{sub 4} compounds

    Energy Technology Data Exchange (ETDEWEB)

    Shemet, V.Ya. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine); Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@univer.lutsk.ua; Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)

    2006-12-21

    The crystal structures of the compounds ScAgSe{sub 2} (space group P3-bar m1, a=0.38779 (2)nm, -bar =0.66501 (5)nm, Pearson symbol hP4, R{sub I}=0.0679) and Sc{sub 1.02}Cu{sub 0.54}Sn{sub 1.1}S{sub 4} (space group Fd3-bar m, a=1.04176 (6)nm, Pearson symbol cF53.28, R{sub I}=0.0624) were determined by means of X-ray powder diffraction. The Se atoms in the structure of the ScAgSe{sub 2} compound are stacked in a close-packed arrangement with the layers in the sequence AB. The Sc atoms occupy half of the octahedral interstices, the Ag atoms occupy remaining octahedral interstices. The S atoms of the Sc{sub 1.02}Cu{sub 0.54}Sn{sub 1.1}S{sub 4} compound are stacked in a close-packed arrangement with the layers in the sequence ABC. The atoms of Sc and statistical mixture M (Sc+Sn) are located in all octahedral interstices, the Cu atoms in 1/8 of the tetrahedral interstices.

  14. High performance AlScN thin film based surface acoustic wave devices with large electromechanical coupling coefficient

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wenbo; He, Xingli; Ye, Zhi, E-mail: yezhi@zju.edu.cn, E-mail: jl2@bolton.ac.uk; Wang, Xiaozhi [Department of Information Science and Electronic Engineering, Zhejiang University and Cyrus Tang Centre for Sensor Materials and Applications, 38 Zheda Road, Hangzhou 310027 (China); Mayrhofer, Patrick M.; Gillinger, Manuel; Bittner, Achim; Schmid, Ulrich [Institute of Sensor and Actuator Systems, Vienna University of Technology, Floragasse, 7/2/366-MST, A-1040 Vienna (Austria); Luo, J. K., E-mail: yezhi@zju.edu.cn, E-mail: jl2@bolton.ac.uk [Institute of Renewable Energy Environmental Technology, University of Bolton, Deane Road, Bolton BL3 5AB (United Kingdom); Department of Information Science and Electronic Engineering, Zhejiang University and Cyrus Tang Centre for Sensor Materials and Applications, 38 Zheda Road, Hangzhou 310027 (China)

    2014-09-29

    AlN and AlScN thin films with 27% scandium (Sc) were synthesized by DC magnetron sputtering deposition and used to fabricate surface acoustic wave (SAW) devices. Compared with AlN-based devices, the AlScN SAW devices exhibit much better transmission properties. Scandium doping results in electromechanical coupling coefficient, K{sup 2}, in the range of 2.0% ∼ 2.2% for a wide normalized thickness range, more than a 300% increase compared to that of AlN-based SAW devices, thus demonstrating the potential applications of AlScN in high frequency resonators, sensors, and high efficiency energy harvesting devices. The coupling coefficients of the present AlScN based SAW devices are much higher than that of the theoretical calculation based on some assumptions for AlScN piezoelectric material properties, implying there is a need for in-depth investigations on the material properties of AlScN.

  15. Parameters of superfine interactions in Laves ScFe sub 2 alloy with hexagonal MnZn sub 2 structure

    CERN Document Server

    Pokatilov, V S

    2001-01-01

    The superfine fields, amplification coefficients and quadrupole splitting on the sup 4 sup 5 Sc nuclei in the ScFe sub 2 , Sc sub 0 sub . sub 9 sub 5 Fe sub 2 sub . sub 0 sub 5 and ScFe sub 1 sub . sub 9 sub 7 Al sub 0 sub . sub 0 sub 3 alloys are measured at the room temperature and 77 K through the method of the nuclear magnetic resonance (NMR). The NMR spectra peculiarities are studied and the superfine field shifts on the sup 4 sup 5 Sc nuclei in the considered alloys by appearance of the Fe atoms at the Sc atoms places and the Al atoms at the Fe atoms places in the Sc atoms nearest coordination sphere are determined. It is established that the electron quadrupole splitting in the considered alloys does not depend on the technology of obtaining the samples, on insignificant deviations from the alloy stoichiometric composition or on the minor additions of the Al atoms

  16. Production of in vivo biotinylated scFv specific to almond (Prunus dulcis) proteins by recombinant Pichia pastoris.

    Science.gov (United States)

    de la Cruz, Silvia; Alcocer, Marcos; Madrid, Raquel; García, Aina; Martín, Rosario; González, Isabel; García, Teresa

    2016-06-10

    The methylotropic yeast Pichia pastoris has demonstrated its suitability for large-scale production of recombinant proteins. As an eukaryotic organism P. pastoris presents a series of advantages at expression and processing of heterologous proteins when compared with Escherichia coli. In this work, P. pastoris has been used to express a scFv from a human synthetic library previously shown to bind almond proteins. In order to facilitate purification and post processing manipulations, the scFv was engineered with a C-terminal tag and biotinylated in vivo. After purification, biotinylated scFv were bound to avidin conjugated with HRP producing a multimeric scFv. The multimeric scFv showed to maintain their ability to recognize almond protein when assayed in ELISA, reaching a LOD of 470mgkg(-1). This study describes an easy method to produce large quantities of in vivo biotinylated scFv in P. pastoris. By substituting the enzyme or fluorochromes linked to avidin, it will be possible to generate a diverse number of multimeric scFv as probes to suit different analytical platforms in the detection of almond in food products. PMID:27085890

  17. Structural and magnetic characterisation of the novel spin frustrated double perovskite Sr2ScMoO6

    International Nuclear Information System (INIS)

    A novel Mo5+ double perovskite, Sr2ScMoO6, has been synthesised. This material crystallises in the tetragonal I4/m symmetry space group and considerable cation disorder between Sc3+ and Mo5+ is observed. Magnetic susceptibility measurements show no evidence of a magnetic transition down to 6 K and no evidence of the valence bond glass state previously reported for A2YMoO6 (A=Ba, Sr). The inverse susceptibility data cannot be fit to the Curie–Weiss law at any temperature range between 6 and 300 K. This deviation from Curie–Weiss law suggests that strong antiferromagnetic correlations are still present in Sr2ScMoO6. - Graphical abstract: A novel double perovskite Sr2ScMoO6 has been synthesised which has corner sharing MoO6 and ScO6 octahedra. The Sr2+ cations reside in the cavities and exhibit anisotropic thermal motion. There is no evidence of magnetic order down to 6 K. - Highlights: • The novel perovskite Sr2ScMoO6 has been synthesised. • Disorder of the Mo5+ and Sc3+ cations is observed. • There is no evidence of a magnetic transition down to 6 K. • There is likely frustrated short range magnetic order or spin liquid behaviour

  18. Radioiodination and biodistribution of the monoclonal antibody TU-20 and its scFv fragment

    International Nuclear Information System (INIS)

    The ability of the monoclonal antibody TU-20 and its scFv fragment to bind specifically to the C-end of the class III β-tubulin makes these substances useful as potential diagnostics for neurodegenerative diseases-especially peripheral neuropathies. TU-20 and its scFv were labeled with 125I and 123I by chloramine-T (with radiochemical yield 75 and 50%, respectively). Radiochemical purity and stability was revealed by gel filtration (decrease to 80 and 50% in 2 months, respectively). Immunoreactivity of the labeled TU-20 was determined by ELISA - the range of the preserved immunoreactivity varies from 60 to 95% in accordance to the used radiolabeling process. RIA and affinity coupling analytic methods were specifically designed with focusing on specifics of the antibody and its fragment. The results of RIA differ in dependence on the type of the reaction vessel (glass or polystyrene) and the affinity coupling results depend on the experimental arrangement - in the batch or on the column. Fragmentation of the labeled antibody and its fragment was estimated by bis-tris gel electrophoresis followed by silver staining and autoradiography (over 95% of radioactivity bound in the substances). The antibody binding in tissue slices was studied in vitro by immunohistochemistry. The Purkinje cells were observed conjugated with the radiolabeled substances, either TU-20 or its ScFv fragment in the area of the cerebellum. In vivo biodistribution of 125I-TU-20, 125I-scFv TU-20, 123I-scFv TU-20 and Na125I was proceeded in normal mice (wild type C57B/6/J). Both biomolecules labeled by 123I were also proved in an imaging biodistribution study with use of the SPECT camera. Finally, a transgene population G93A1 Gur was used for comparative study to show the different behaviour of the substances in a normal mouse and in the modified organism with amyotrophic lateral sclerosis. The most part of differences is observed in the area of the muscles, rostal and caudal spinal cord. In summary

  19. Development of methods for the selective separation of Sc for use in nuclear medicine

    International Nuclear Information System (INIS)

    Full text of publication follows. Scandium radioisotopes are increasingly finding application in PET imaging or targeted therapy [Ref.1]. They can be produced in a no-carrier-added form through various charged particle reactions using Ti or Ca targets [Refs.1,2]. In order to provide Sc of sufficient quantity and quality, fast and reliable methods for its production are needed, including, depending on the production route, the quantitative recovery of the target material. Extraction chromatographic resins allow an easy adjustment of selectivity, show fast kinetics and high capacity and are thus well suited for fast and selective separations [Ref.3]. The aim of the presented project is the development of methods for the separation of Sc radionuclides from irradiated targets. The development of the methods includes the determination of k' values of Sc, Ca, Ti and other potentially interfering elements and impurities for varying Resins, notably TRU and DGA resin, acids and pH values and the influence of macro amounts of Ti and Ca on the extraction of Sc. Elution studies were performed in order to evaluate best suited rinsing/elution conditions and volumes. Based on the obtained results, methods for the separation of Sc and its purification, from irradiated targets were developed and tested on simulated Ti and Ca targets. In order to further improve the separation new extraction chromatographic resins based on the coated nano-tubes were prepared and tested. The recovery of the target materials will also be addressed. References: [1] K. L. Kolsky, V. Joshi, L. F. Mausner and S. C. Srivastava; Radiochemical Purification of No-carrier- added Scandium-47 for Radioimmunotherapy, Appl. Radiat. Isot. Vol. 49, No. 12, pp. 1541-1549, 1998; [2] Sadeghi, Mahdi; Enferadi, Milad; Aref, Morteza; Jafari, Hoda, Nuclear data for the cyclotron production of 66Ga, 86Y, 76Br, 64Cu and 43Sc in PET imaging, Nukleonika, Volume 55, Issue 3, 293-302 (2010); [3] Horwitz, E.P., McAlister, D

  20. 44Sc: An Attractive Isotope for Peptide-Based PET Imaging

    Science.gov (United States)

    2015-01-01

    The overexpression of integrin αvβ3 has been linked to tumor aggressiveness and metastasis in several cancer types. Because of its high affinity, peptides containing the arginine–glycine–aspartic acid (RGD) motif have been proven valuable vectors for noninvasive imaging of integrin αvβ3 expression and for targeted radionuclide therapy. In this study, we aim to develop a 44Sc-labeled RGD-based peptide for in vivo positron emission tomography (PET) imaging of integrin αvβ3 expression in a preclinical cancer model. High quality 44Sc (t1/2, 3.97 h; β+ branching ratio, 94.3%) was produced inexpensively in a cyclotron, via proton irradiation of natural Ca metal targets, and separated by extraction chromatography. A dimeric cyclic-RGD peptide, (cRGD)2, was conjugated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and radiolabeled with 44Sc in high yield (>90%) and specific activity (7.4 MBq/nmol). Serial PET imaging of mice bearing U87MG tumor xenografts showed elevated 44Sc-DOTA-(cRGD)2 uptake in the tumor tissue of 3.93 ± 1.19, 3.07 ± 1.17, and 3.00 ± 1.25 %ID/g at 0.5, 2, and 4 h postinjection, respectively (n = 3), which were validated by ex vivo biodistribution experiments. The integrin αvβ3 specificity of the tracer was corroborated, both in vitro and in vivo, by competitive cell binding and receptor blocking assays. These results parallel previously reported studies showing similar tumor targeting and pharmacokinetic profiles for dimeric cRGD peptides labeled with 64Cu or 68Ga. Our findings, together with the advantageous radionuclidic properties of 44Sc, capitalize on the relevance of this isotope as an attractive alternative isotope to more established radiometals for small molecule-based PET imaging, and as imaging surrogate of 47Sc in theranostic applications. PMID:25054618

  1. Investigation on Mg and Sc co-doped Ceria electrolyte for IT-SOFC

    Directory of Open Access Journals (Sweden)

    P.Ravi Chandran

    2014-07-01

    Full Text Available Nanocrystalline form of pure ceria (CeO2 and metal (Mg or Sc doped ceria was attempted for 10 mol %. Also, Mg and Sc co-doped ceria with Ce1-x(Mg0.5Sc0.5xO2 (x=0-0.24 was prepared as an electrolyte for intermediate temperature solid oxide fuel cells (IT-SOFCs by co-precipitation method. The synthesized different compositions of pure and doped nanocrystalline powders were then subjected to powder X-ray diffraction (XRD for phase and structural identification. All the nanocrystalline samples were found to be ceria based solid solutions of fluorite type structures. A.C. impedance spectroscopy measurements in the frequency range of 50Hz to 5MHz was carried out to study the grain, grain boundary and ionic conductivity of doped ceria samples in the temperature range of 400-600oC. The sample Ce0.84(Mg0.5Sc0.50.16O2 composition showed highest ionic conductivity i.e., 1.923 x 10-2 S/cm at 500oC. Its morphology and composition was investigated using scanning electron microscopic analysis (SEM and energy dispersive X-ray spectrometry (EDS and conductivity behavior was compared with those of pure ceria and singly doped ceria electrolytes namely Ce0.9Mg0.1O2 and Ce0.9Sc0.1O2. The impedance analysis reveals that the sample Ce0.9Mg0.1O2 was found to have higher ionic conductivity compared to Ce0.9Sc0.1O2 in the temperature range of 400–600°C. The co-doped ceria showed a much higher conductivity in air at 500oC in comparison to that of singly doped ceria. Therefore, these co-doped ceria are also the more ideal electrolyte materials for IT-SOFCs. Nyquist plot shows the major contributions were due to the grain boundary resistance contributions which accounts for the higher ionic conductivity in case of the dopants. These dopant effect on the ceria is discussed in detail.

  2. MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.

    OpenAIRE

    Marin IONICĂ; Popescu, Marian; Radu TOMESCU

    2012-01-01

    Through this scientific research report “MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.” we plan to investigate the remuneration and stimulation method from the human resources department within S.C. Tasmania. Studying in detail the personnel’s remuneration and stimulation we have tried to present the main policy aspects at S.C. Tasmania in human resources domain: integration of the human resource management in the overall management of the...

  3. Production and characterization of a recombinant anti-MUC1 scFv reactive with human carcinomas.

    OpenAIRE

    Denton, G; Sekowski, M.; Spencer, D. I.; Hughes, O. D.; Murray, A; Denley, H; Tendler, S. J.; Price, M. R.

    1997-01-01

    Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display technology and gene expression systems in E. coli has led to the production of soluble C595 scFv. The scFv has been purified from the bacterial supernatant by peptide epitope affi...

  4. Transcriptional stimulation via SC site of Bombyx sericin-1 gene through an interaction with a DNA binding protein SGF-3.

    OpenAIRE

    Matsuno, K.; Takiya, S; Hui, C C; Suzuki, T.; Fukuta, M.; Ueno, K.; Suzuki, Y

    1990-01-01

    Three protein binding sites have been identified in the upstream region of the sericin-1 gene. Two of them, SA and SC sites, have been known as putative cis-acting elements. Using synthetic oligonucleotides of these binding sites, it was found that silk gland factor-1 (SGF-1) binds to the SA site, and silk gland factor-3 (SGF-3) binds to the SC site but not to a mutated SC site, SCM. Tissue distribution of the two factors was different. SGF-3 is present abundantly in the middle silk gland (MS...

  5. Lytic Polysaccharide Monooxygenases ScLPMO10B and ScLPMO10C Are Stable in Ionic Liquids As Determined by Molecular Simulations.

    Science.gov (United States)

    Sprenger, K G; Choudhury, Alaksh; Kaar, Joel L; Pfaendtner, Jim

    2016-04-28

    Lytic polysaccharide monooxygenases (LPMOs) are a newly discovered family of enzymes proposed to work synergistically with cellulases and aid in the decomposition of cellulose for the creation of environmentally friendly fuels and chemicals. To our knowledge, evaluation of the stability of LPMOs in ionic liquid (IL) solvents at relevant biomass processing conditions has not been explored. Herein, molecular dynamics simulations of ScLPMO10B and ScLPMO10C in three ILs at 10 and 20 wt% in water and in pure water have been performed. Enzyme stability was predicted to be high on the basis of structural and dynamic analyses we performed. We used the simulations to identify key areas that deviate from the crystal structures as a starting place for surface charge modifications to increase stability in ILs. Results show that, in general, both enzymes have a high degree of stability across the range of IL solutions tested. For each enzyme, two regions were identified that showed notable deviations from the crystal structure. In addition to providing a basis for future rational design efforts, this work represents a first step toward engineering LPMOs to function efficiently in enzyme cocktails for use in industrial biomass processing applications with ILs. PMID:27052057

  6. Structural characterization and biological activities of SC4,an acidic polysaccharide from Salvia chinensis%石见穿酸性多糖SC4的结构特征和生物活性

    Institute of Scientific and Technical Information of China (English)

    刘翠平; 方积年; 李晓玉; 萧晓秋

    2002-01-01

    AIM:To study the chemical characterization and some biological activities of an acidic polysaccharide,named SC4 from Salvia chinensis.METHODS:Chemical and spectral methods were employed to identify the structural characterization of SC4.Effect of SC4 on the proliferation of T- and B-lymphocytes both in vivo and in vitro was measured at various concentrations,and the protective effects of SC4 on PC12 cells against H2O2-induced injury was observed.RESULTS:SC4 was a highly branched polysaccharide with mean molecular weight of 4.5 × 105,composed of Rha,Xyl,Set,Gal,and GalA in the molar ratio of 1.0:7.0:5.3:1.2:4.2.Methylation analysis and NMR identified the linkages of the residues of SC4.SC4 increased the B-lymphocyte proliferation and spleen weight remarkably while no obvious changes were examined in T-lymphocyte proliferation,thymus weight,and the level of IgG and C3 in blood of mice.Moreover,SC4 enhanced the PC12 cells viability after H2O2 treatment.CONCLU-SION:SC4,the acidic polysaccharide with complicated structure,was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2-induced injury.%目的:研究从石见穿(Salvia chinensis)中得到的酸性多糖SC4的化学结构和生物活性.方法:利用化学和光谱方法分析了SC4的结构特征,并观察了SC4对淋巴细胞增殖的影响以及增强PC12细胞对抗H2O2造成的损伤的作用.结果:SC4的分子量为4.5×105,由Rha,Xyl,Ser,Gal和GalA组成,摩尔比为1.0:7.0:5.3:1.2:4.2.甲基化和13C NMR进一步确定了SC4中各糖残基的连接方式.SC4能显著促进B淋巴细胞的增殖,增加小鼠脾重,增强PC12细胞对抗H2O2造成的氧化损伤的能力.结论:SC4为一多分枝的酸性多糖,其免疫活性的靶细胞为B淋巴细胞,并显著增强PC12细胞对抗H2O2造成的损伤的能力.

  7. b172sc.m77t - MGD77 data file for Geophysical data from field activity B-1-72-SC in Central California from 11/11/1972 to 11/15/1972

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry, gravity, and magnetics data along with transit satellite navigation data was collected as part of field activity B-1-72-SC in Central...

  8. mini Style 松下直板手机SC3评测

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    松下2005年最拉风的产品莫过于6系列和7系列的折叠机.屏幕清晰靓丽.可谓出尽风头。同时.松下还发布了两款低端直板手机.使得产品线更趋丰富,A210和SC3造型小巧到极至.一规矩方正一可爱圆润.是非常不错的学生机。尽管上市有些时日.仍得到用户关注.其中SC3更是得到师哥靓妹的青睐。

  9. Theoretical Calculations of Transition Probabilities and Oscillator Strengths for Sc(Ⅲ) and Y(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    Tian-yi Zhang; Neng-wu Zheng

    2009-01-01

    The Weakest Bound Electron Potential Model theory is used to calculate transition probability-values and oscillator strength-values for individual lines of Sc(Ⅲ) and Y(Ⅲ). In this method, by solving the SchrSdinger equation of the weakest bound electron, the expressions of energy eigenvalue and the radial function can be obtained. And a coupled equation is used to determine the parameters which are needed in the calculations. The ob-tained results of Sc(Ⅲ) from this work agree very well with the accepted values taken from the National Institute of Standards and Technoligy (NIST) data base, most deviations are within the accepted level. For Y(Ⅲ) there are no accepted values reported by the NIST data base. So we compared our results of Y(Ⅲ) with other theoretical results, good agreement is also obtained.

  10. Validation of the ATHLET-SC code by trans-critical transient data

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiaojing; Cheng, Xu [Shanghai Jiao Tong Univ. (China). School of Nuclear Science and Engineering

    2016-05-15

    For the safety analysis of Supercritical Water-Cooled Reactor (SCWR), one of the challenge tasks is to predict the trans-critical behavior of the reactor system during some accidents. The current safety codes have some shortcomings when the pressure decreases from the supercritical condition to the subcritical state due to the void fraction discontinuity across the critical point. Another challenge is the validation of the system code, which needs the transient experimental data. To overcome the above-mentioned challenges, this paper validates the modified code ATHLET-SC, which is developed based on the pseudo two-phase method. The trans-critical transient data from SWAMUP test facility in Shanghai Jiao Tong University (SJTU) are adopted to compare with the simulation results. The results obtained so far shows that the ATHLET-SC code has good feasibility to the trans-critical simulation of SCWR, and it can be used for transient analysis of SCWR in the future.

  11. The Fourier Transform Microwave/millimeter Spectrum of ScO (X^2Σ^+)

    Science.gov (United States)

    Halfen, D. T.; Min, J.; Ziurys, L. M.

    2013-06-01

    The pure rotational spectra of ScO (X^2Σ^+) have been recorded in the 4 - 90 GHz range using Fourier transform microwave/millimeter (FTM/mmW) techniques. This species was created in a supersonic jet expansion of laser-ablated scandium vapor and N_2O gas, diluted in argon. The N = 1 → 0 and 2 → 1 rotational transitions in both v = 0 and 1 have been measured near 30 and 61 GHz, respectively. The data over 60 GHz were obtained using a new E-band (60 - 90 GHz) FTmmW spectrometer system. The data have been analyzed, and rotational, fine, and hyperfine constants have been determined, which are in good agreement with those from past optical studies. ScO is a potential circumstellar molecule in giant/supergiant stars, where it is produced in oxygen-burning nucleosynthesis.

  12. On the Perils of Hyperfine Splitting A reanalysis of Mn and Sc Abundance Trends

    CERN Document Server

    Prochaska, J X; Prochaska, Jason X.; William, Andrew Mc

    2000-01-01

    We investigate the impact of hyperfine splitting on stellar abundance analyses of Mn and Sc, and find that incorrect hfs treatment can lead to spurious abundance trends with metallicity. We estimate corrections to a recent study by Nissen et al. (2000), and find: (1) [Mn/Fe] is described by a bimodal distribution, with [Mn/Fe] ~ -0.3 for stars [Fe/H] < -0.7, and [Mn/Fe] ~ -0.05 for stars at higher metallicity, suggestive of a transition between halo/thick disk and thin disk populations. (2) The large majority of stars show nearly solar [Sc/Fe] ratios; although important deviations cannot be ruled-out.

  13. Development of pico-second pulse radiolysis system using SC probe light

    International Nuclear Information System (INIS)

    Pulse radiolysis is one of the most important and powerful means for detecting transient and relaxation phenomena and following their behavior in irradiated systems. We have been studying on pulse radiolysis system with Cs-Te photo cathode RF-gun at Waseda University. Stable short pulse white light generation is a key for the pulse radiolysis system. Recently, it can be generated by Photonic Crystal Fibre(PCF) in which laser field is high enough for producing nonlinear optical effect and produces a white spectra short pulse, called Super Continuum (SC) . Then we firstly tried to apply SC light as a candidate for a probe-light in pico-second pulse radiolysis system. Its S/N ratio and time resolution are 38, 22ps(rms) respectively. (author)

  14. Rich radioprotective profiles of two indigenous medicinal plants Andrographis paniculata (Ap) and Swertia chirata (Sc)

    International Nuclear Information System (INIS)

    The extracts of two indigenous medicinal plants, Andrographis paniculata (Ap) and Swertia chirata (Sc) were selected to study if they could prevent generation of reactive oxygen species (ROS) during radiation exposure. Rat liver mitochondria exposed to γ-radiation (450Gy) resulted significant oxidative damage as exemplified by enhanced formation in various lipid peroxidation products, conjugated dienes (CD), lipid hydroperoxide (LOOH), TBARS as well as hydroxylnonenals. Simultaneous addition of Ap or Sc (50 mg/ml) extracts during radiation could significantly reverse such damage. Extracts showed high reducing equivalents, phenolic contents and displayed high scavenging activity with superoxide and hydroxyl radicals. The pulse radiolysis studies exhibited high reactivity with ABTS. Based on these observation, the plant extracts, Andrographis paniculata and Swertia chirata may emerge as effective radioprotective agents, protecting cells from radiation-induced injury. (author)

  15. Sc Κα and Κβ X-ray fluorescence spectra

    International Nuclear Information System (INIS)

    X-ray fluorescence spectrometry is now one of the most powerful tools for quantitative elemental analysis as well as chemical state analysis of new materials. A complete theoretical understanding of the X-ray emission process still does not exist even after the century following the discovery of X-rays. The major motivation of this study is to clarify the origin of the chemical effects of X-ray emission lines so as to better utilize these chemical effects for chemical state analysis or characterization. The origins of the chemical effects on the XRF satellites of Sc are discussed and a systematic study on the chemical shifts of Sc Kα1 and Kβ1.3 lines of scandium metal and various scandium compounds is presented. (author)

  16. Magnetic properties of Fe{sub 90}Sc{sub 10} nanoglass

    Energy Technology Data Exchange (ETDEWEB)

    Witte, Ralf [Technische Universitaet Darmstadt, Gemeinschaftslabor Nanomaterialien, Petersenstr. 23, D-64287 Darmstadt (Germany); Karlsruher Institut fuer Technologie, Institut fuer Nanotechnologie, D-76344 Eggenstein-Leopoldshafen (Germany); Fang, Jixiang; Ghafari, Mohammad; Kruk, Robert; Brand, Richard A.; Hahn, Horst; Gleiter, Herbert [Karlsruher Institut fuer Technologie, Institut fuer Nanotechnologie, D-76344 Eggenstein-Leopoldshafen (Germany)

    2011-07-01

    We report on our work on magnetic properties and their correlation with local structure in Fe-Sc nanoglasses. Samples were synthesized with a nominal composition of Fe{sub 90}Sc{sub 10} in an inert-gas condensation (IGC) process. X-ray diffraction, Moessbauer spectroscopy as well as magnetometric characterization methods were applied to characterize the samples. Magnetometric measurements revealed a significant change of magnetic properties in the Fe rich compound marked by an increase of the Curie point to temperatures well above 300 K, which is much higher than the transition temperature in regular metallic glasses of similar composition. The maximum magnetic hyperfine field obtained from low temperature Moessbauer spectroscopy was about 37.5 T, which is much more than observed in bcc-Fe. This newly identified ferromagnetic phase is attributed to the modified short-range-order in the interfaces of adjacent amorphous nanoparticles.

  17. Electronic structure and binding energy relaxation of ScZr atomic alloying

    Science.gov (United States)

    Bo, Maolin; Guo, Yongling; Yang, Xuexian; He, Junjie; Liu, Yonghui; Peng, Cheng; Huang, Yongli; Sun, Chang Q.

    2016-07-01

    We examined the combined effect of atomic under- and hetero-coordination on the bond relaxation and electronic binding energy of Sc, Zr, and ScZr alloying using a combination of the bond-order-length-strength (BOLS) correlation and density functional theory (DFT) calculations. Observations strongly emphasize the relevance of core-level shifts as reliable X-ray photoelectron spectroscopy experimental descriptors of core-shell catalysis reactivity, along with under-coordinated atoms in bimetallic transition metal systems. The BOLS-DFT method provides enhanced catalysis reactivity and detects surface and alloy configurations, opening up the possibility to investigate more complex systems with irregularly under- and hetero-coordinated atoms.

  18. Supercritical CO2 direct cycle Gas Fast Reactor (SC-GFR) concept.

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Steven Alan; Parma, Edward J., Jr.; Suo-Anttila, Ahti Jorma (Computational Engineering Analysis, Albuquerque, NM); Al Rashdan, Ahmad (Texas A& M University, College Station, TX); Tsvetkov, Pavel Valeryevich (Texas A& M University, College Station, TX); Vernon, Milton E.; Fleming, Darryn D.; Rochau, Gary Eugene

    2011-05-01

    This report describes the supercritical carbon dioxide (S-CO{sub 2}) direct cycle gas fast reactor (SC-GFR) concept. The SC-GFR reactor concept was developed to determine the feasibility of a right size reactor (RSR) type concept using S-CO{sub 2} as the working fluid in a direct cycle fast reactor. Scoping analyses were performed for a 200 to 400 MWth reactor and an S-CO{sub 2} Brayton cycle. Although a significant amount of work is still required, this type of reactor concept maintains some potentially significant advantages over ideal gas-cooled systems and liquid metal-cooled systems. The analyses presented in this report show that a relatively small long-life reactor core could be developed that maintains decay heat removal by natural circulation. The concept is based largely on the Advanced Gas Reactor (AGR) commercial power plants operated in the United Kingdom and other GFR concepts.

  19. : Les mises en scène audiovisuelles des fusillades dans les écoles

    OpenAIRE

    Paton, Nathalie; Figeac, Julien

    2015-01-01

    International audience Le présent article décrit la façon dont les auteurs de fusillades dans les écoles ont pu diffuser des vidéos, avant de passer à l'acte, grâce aux ressources des médias participatifs. Ces personnes tentent de « préméditer » leur tuerie en proposant aux entreprises de presse des scénarisations audiovisuelles de leur identité et de leur projet meurtrier. L'analyse détaillée de ces scénarisations révèle comment elles exploitent les ressorts performatifs de slogans ou de ...

  20. Scénariser l’apprentissage, une activité de modélisation

    OpenAIRE

    Jean-Philippe Pernin; Hélène Godinet; Richard Hotte

    2007-01-01

    [Français] Un regard sur la scénarisation pédagogique: Depuis le début des années 2000, un ensemble de travaux de recherche et d’initiatives de terrain visent à proposer ou à utiliser des modèles, des méthodes et des outils pour concevoir, mettre en place, exploiter et analyser les scénarios d’apprentissage. Sur le plan international, on peut citer en particulier les travaux menés par Koper et Tattersall, (2005) portant sur les langages de modélisation pédagogique et plus spécifiquement autou...

  1. Which Is The Best Sandwich Compound? Hexaphenylbenzene Substituted By Sandwich Compounds Bearing Sc, Cr, and Fe.

    Science.gov (United States)

    Ramos, Estrella; Martínez, Ana; Rios, Citlalli; Salcedo, Roberto

    2015-11-25

    The electronic properties of nine different hexaarylbenzene molecules substituted by sandwich compounds have been studied by applying density functional theory. Different structures and the particular electron donor power of these systems have been considered in order to analyze their oxidant capacity, using bis(ciclopentadienyl) scandium, ferrocene, and bis(benzene)chromium as sandwich compounds. Both monometallic and bimetallic combinations are investigated. According to the ionization energies and electron affinities, compounds with Cr are nucleophiles and represent the best electron donors, whereas compounds with Sc are electrophiles and represent the best electron acceptors. The worse electron donor or acceptor is hexakis(4-ferrocenyl phenyl) benzene. This is very significant, as it implies that the very well-known electronic properties of hexakis(4-ferrocenyl phenyl) benzene can be improved by substituting with other metals, such as Sc and Cr. This suggests several possible applications for these compounds. PMID:26528582

  2. Structural characterization and ytterbium spectroscopy in Sc{sub 2}O{sub 3} nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Galceran, M. [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain); Pujol, M.C., E-mail: mariacinta.pujol@urv.ca [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain); Carvajal, J.J.; Mateos, X. [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain); Zaldo, C. [Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientificas (CSIC), c/ Sor Juana Ines de la Cruz 3, E-28049 Madrid (Spain); Aguilo, M.; Diaz, F. [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain)

    2010-08-15

    Ytterbium-doped scandium oxide nanocrystals measuring less than 25 nm with compositions of Sc{sub 2-x}Yb{sub x}O{sub 3} (x=0.001-1) were prepared using the modified Pechini method. The Yb:Sc{sub 2}O{sub 3} nanocrystals were obtained by calcination at low temperature such as 1073 K for 2 h. X-ray powder diffraction (XRD) and transmission electronic microscopy (TEM) were used to perform the structural characterization of nanocrystals; these studies indicated that the nanocrystals have high crystalline quality with cubic structure and Ia3-bar space group. The morphology and particle size were studied using electron microscopy. A detailed study of the effect of the nanodimension and the ytterbium concentration on the spectroscopic characteristics of Yb{sup 3+} as an active ion was carried out in terms of optical absorption, optical emission and fluorescence decay time at room and low temperature.

  3. Validation of the ATHLET-SC code by trans-critical transient data

    International Nuclear Information System (INIS)

    For the safety analysis of Supercritical Water-Cooled Reactor (SCWR), one of the challenge tasks is to predict the trans-critical behavior of the reactor system during some accidents. The current safety codes have some shortcomings when the pressure decreases from the supercritical condition to the subcritical state due to the void fraction discontinuity across the critical point. Another challenge is the validation of the system code, which needs the transient experimental data. To overcome the above-mentioned challenges, this paper validates the modified code ATHLET-SC, which is developed based on the pseudo two-phase method. The trans-critical transient data from SWAMUP test facility in Shanghai Jiao Tong University (SJTU) are adopted to compare with the simulation results. The results obtained so far shows that the ATHLET-SC code has good feasibility to the trans-critical simulation of SCWR, and it can be used for transient analysis of SCWR in the future.

  4. Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease.

    Science.gov (United States)

    Squiers, John J; Edwards, Anthony G; Parra, Alberto; Hofmann, Sandra L

    2016-01-01

    A 70-year-old African American female with a past medical history significant for chronic bilateral shoulder pain and reported sickle cell trait presented with acute-onset bilateral thoracolumbar pain radiating to her left arm. Two days after admission, Hematology was consulted for severely worsening microcytic anemia and thrombocytopenia. Examination of the patient's peripheral blood smear from admission revealed no cell sickling, spherocytes, or schistocytes. Some targeting was noted. A Coombs test was negative. The patient was eventually transferred to the medical intensive care unit in respiratory distress. Hemoglobin electrophoresis confirmed a diagnosis of hemoglobin SC disease. A diagnosis of acute splenic sequestration crisis complicated by acute chest syndrome was crystallized, and red blood cell exchange transfusion was performed. Further research is necessary to fully elucidate the pathophysiology behind acute splenic sequestration crisis, and the role of splenectomy to treat hemoglobin SC disease patients should be better defined. PMID:27047980

  5. Optical properties and radiation response of Ce3+-doped GdScO3 crystals

    International Nuclear Information System (INIS)

    10%-Ce doped GdScO3 perovskite type single crystal was grown by the Czochralski process. The Ce concentration in the crystal was measured. No impurity phases were observed by powder X-ray diffraction analysis. We evaluated the optical and radiation properties of the grown crystal. Ce:GdScO3 crystal showed photo- and radio-luminescence peaks due to Ce3+ of 5d-4f transition and colour centre. The photoluminescence decay time was sub-ns order. The relative light yield under 5.5 MeV alpha-ray excitation was calculated to be approximately 9% of BGO. (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  6. L’excès dans la représentation scénographique

    OpenAIRE

    Rivier, Estelle

    2008-01-01

    À l’époque victorienne, les décors monumentaux et changeants suscitaient l’admiration du public et constituaient l’attrait majeur de la représentation d’une pièce de théâtre. Que l’on songe par exemple aux mises en scène de Herbert Beerbohm Tree qui nécessitaient des coupes drastiques dans le texte afin que des hordes de figurants, humains ou animaux, aient le temps de venir habiter l’espace scénique. Au début du xxe siècle en France, le naturalisme donne également lieu à des décors pharaoniq...

  7. High-pressure study of ScVO4 by Raman scattering and ab initio calculations

    Science.gov (United States)

    Panchal, V.; Manjón, F. J.; Errandonea, D.; Rodriguez-Hernandez, P.; López-Solano, J.; Muñoz, A.; Achary, S. N.; Tyagi, A. K.

    2011-02-01

    We report results of experimental and theoretical lattice-dynamics studies on scandium orthovanadate up to 35 GPa. Raman-active modes of the low-pressure zircon phase are measured up to 8.2 GPa, where the onset of an irreversible zircon-to-scheelite phase transition is detected. Raman-active modes in the scheelite structure are observed up to 16.5 GPa. Beyond 18.2 GPa we detected a gradual splitting of the Eg modes of the scheelite phase, indicating the onset of a second phase transition. Raman symmetries, frequencies, and pressure coefficients in the three phases of ScVO4 are discussed in the light of ab initio lattice-dynamics calculations that support the experimental results. The results on all the three phases of ScVO4 are compared with those previously reported for related orthovanadates.

  8. Particle-hole configurations and energy spectra of 42Ca, 42Sc and 42Ti nuclei

    International Nuclear Information System (INIS)

    Shell-model calculations are performed to investigate the level structure in 42Ca, 42Sc and 42Ti nuclei. The shell model states are expressed for two-particle, particle-hole and three-particle one-hole configurations in terms of coupled two-particle states. We have used the modified surface-delta interaction, pairing and Coulomb interaction in this calculation. The configurations considered are 1f7/2, 2p3/2 and 1d3/2 Single-particle energies and parameters of the interaction are determined by least-squares fitting procedure. The resulting two-body matrix elements are applied to calculate the energy spectra of two-particle states and three-particle one-hole states in 42Ca, 42Sc and 42Ti nuclei

  9. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation

    Science.gov (United States)

    Weis, MaryAnn; Rai, Jyoti; Hudson, David M.; Dimori, Milena; Zimmerman, Sarah M.; Hogue, William R.; Swain, Frances L.; Burdine, Marie S.; Mackintosh, Samuel G.; Tackett, Alan J.; Suva, Larry J.; Eyre, David R.

    2016-01-01

    Collagen is a major component of the extracellular matrix and its integrity is essential for connective tissue and organ function. The importance of proteins involved in intracellular collagen post-translational modification, folding and transport was recently highlighted from studies on recessive forms of osteogenesis imperfecta (OI). Here we describe the critical role of SC65 (Synaptonemal Complex 65, P3H4), a leprecan-family member, as part of an endoplasmic reticulum (ER) complex with prolyl 3-hydroxylase 3. This complex affects the activity of lysyl-hydroxylase 1 potentially through interactions with the enzyme and/or cyclophilin B. Loss of Sc65 in the mouse results in instability of this complex, altered collagen lysine hydroxylation and cross-linking leading to connective tissue defects that include low bone mass and skin fragility. This is the first indication of a prolyl-hydroxylase complex in the ER controlling lysyl-hydroxylase activity during collagen synthesis. PMID:27119146

  10. Improving SC-FDMA performance by Turbo Equalization in UTRA LTE Uplink

    DEFF Research Database (Denmark)

    Berardinelli, Gilberto; Priyanto, Basuki Endah; Sørensen, Troels Bundgaard;

    2008-01-01

    does not have stringent power constraints. In this paper, a turbo equalization technique to improve Single Carrier Frequency Division Multiple Access (SC-FDMA) performance is proposed. A new adaptive coefficients solution for frequency domain equalization is considered. The work is in the context of...... the turbo equalizer can improve the BLER performance around 1 dB with only a few iterations, and improve the SC-FDMA performance over OFDM, especially at high coding rate.......Turbo equalization is known as an advanced iterative equalization and decoding technique that allows to enhance the performance of the data transmission over a frequency selective fading channel. The turbo equalizer will result in extra receiver complexity, but isolated to the base-station, which...

  11. Crystal structures of new ternary rare earth silicides Sc3Pr2Si4, Sc1.26Pr3.74Si4 and Sc3.96Nd1.04Si4 with ordered and partially ordered rare earth sites

    International Nuclear Information System (INIS)

    The crystal structures of three new ternary silicides Sc3Pr2Si4, Sc1.26Pr3.74Si4 and Sc3.96Nd1.04Si4 were determined by single crystal X-ray diffraction. The title compounds crystallize with three different substitution derivatives of the Sm5Ge4 structure type (orthorhombic space group Pnma) containing various distributions of rare earth atoms on the three Sm sites. Crystal chemistry analysis shows that these distributions are controlled by the atomic size factor. (orig.)

  12. Thermodynamic modeling of the RE–Pb (RE = Sc, Dy, Gd) systems

    Energy Technology Data Exchange (ETDEWEB)

    Iddaoudi, A., E-mail: iddaoudi19@gmail.com [Laboratoire de Thermodynamique et Energétique, LTE, Université Ibn-Zohr, B.P. 8106 Agadir (Morocco); Servant, C., E-mail: colette.servant@orange.fr [Laboratoire de Physicochimie de l’Etat Solide, ICMMO, Université Paris-Sud, 91405 Orsay Cedex (France); Selhaoui, N.; Kardellass, S.; Mahdouk, K.; Bouirden, L. [Laboratoire de Thermodynamique et Energétique, LTE, Université Ibn-Zohr, B.P. 8106 Agadir (Morocco)

    2014-03-15

    Highlights: • Rare earth (RE) and Pb alloys or compounds are interesting as magnetic materials. • The phase diagrams and thermodynamic properties of RE–Pb (RE = Sc, Dy, Gd) systems have been assessed. • The CALPHAD method was used with the Redlich–Kister model to optimize the solution phases. • A self-consistent set of thermodynamic parameters has been evaluated. • A good agreement was found between the calculation and experiments. -- Abstract: The phase diagrams and thermodynamic properties of RE–Pb (RE = Sc, Dy, Gd) systems have been assessed by means of the CALPHAD method. The solution phases (liquid, fcc, bcc and hcp) were described by the sublattice formalism and the excess term of the Gibbs energy with the Redlich–Kister equation. The stoichiometric intermetallic compounds (Sc{sub 5}Pb{sub 3}, Sc{sub 6}Pb{sub 5}, Dy{sub 5}Pb{sub 4}, DyPb, DyPb{sub 2}, DyPb{sub 3}, β-Gd{sub 5}Pb{sub 4}, α-Gd{sub 5}Pb{sub 4}, Gd{sub 11}Pb{sub 10}, Gd{sub 6}Pb{sub 7}, GdPb{sub 2} and GdPb{sub 2}) were modeled as line compounds. The non-stoichiometric Dy{sub 5}Pb{sub 3} and Gd{sub 5}Pb{sub 3} phases with a narrow homogeneity range were modeled using a two-sublattice model with substitution. A consistent set of the thermodynamic parameters leading to a reasonable agreement between the calculated results and literature data was obtained.

  13. Lowermost mantle anisotropy beneath the north Pacific from differential S-ScS splitting

    Science.gov (United States)

    Wookey, James; Kendall, J.-Michael; Rümpker, Georg

    2005-06-01

    Seismic anisotropy is an important tool for studying the nature, origin and dynamics of the lowermost mantle (D''). We introduce differential S-ScS splitting as a tool for removing the effect of near-source and near-receiver anisotropy to estimate splitting accrued in the D'' region. This is applicable to events recorded at epicentral distances between 60° and 85°. Near-source anisotropy has often been ignored in previous studies of lowermost mantle anisotropy. We apply differential S-ScS splitting to records from Canadian National Seismic Network stations of western Pacific earthquakes; these sample the lowermost mantle beneath the north Pacific. The residual splitting in ScS, which we attribute to D'', shows lag times between 1.0 and 3.9 s. Given the near horizontal ray path of ScS in D'', we interpret the recovered fast directions as the orientation of the fast shear wave in the plane defined by the vertical and transverse directions and observe a clearly non-VTI (transverse isotropy with a vertical axis of symmetry) style of anisotropy. The largest population of results shows an approximately southeasterly dipping symmetry axis which we speculate might be explained by descending palaeoslab material being swept horizontally across the core-mantle boundary towards an upwelling region beneath the central Pacific. Non-VTI symmetry and the many possible contributions to D'' anisotropy from lower-mantle minerals, melt and subducted materials suggest that our understanding of the lowermost mantle could be greatly improved by trying to resolve a more general style of anisotropy.

  14. Application of a two energy group analytical solution to the Yalina experiment SC3A

    International Nuclear Information System (INIS)

    The SC3A experiment in the YALINA-Booster facility is described and investigated. For this investigation the very special configuration of YALINA-Booster is analyzed based on HELIOS calculations. To improve the representation to this special configuration a new analytical solution for two energy groups with two sources (central external and boundary source) has been developed starting form the Green's function solution. Very good agreement has been found for these improved analytical solutions. (author)

  15. Artemisinin content of sc-C0₂ derived extracts from Artemisia annua / Surisha Padayatchi.

    OpenAIRE

    Padayatchi, Surisha

    2004-01-01

    One of the principal research themes of the supercritical fluid research group within the Centre of Separation Science and Technology (SST) at the North-West University (Potchefstroom Campus) is botanical extraction. The group produces botanical extracts from locally cultivated plants which contain substances (essential oils, natural waxes) relevant to the food, flavour, pharmaceutical, medical and cosmetic industries while utilising the advantages of sc-C& extraction over traditi...

  16. Zerstörungsfreie Gleitsystemanalyse an der einkristallinen Hochtemperaturlegierung SC16 bei mittlerer Orientierung der Zugachse

    OpenAIRE

    Geburtig, Anja

    2002-01-01

    Die Oberflächen von einkristallinen SC16-Proben quadratischen Querschnitts werden im Anschluss an eine Zugbelastung nach Gleitspuren durchsucht, um aus Verlauf und Höhenstufung sowie der Kenntnis der Kristallorientierung in der Probe die aktivierten Gleitsysteme zu bestimmen. Die Proben mit mittiger Orientierung der Zugachse werden mehrfach bis maximal etwa 0,2 % plastischer Restdehnung verformt. Für die Topografie-Untersuchungen findet die Weißlicht-Interferenz-Mikroskopie Anwendung, die die...

  17. Molecular dynamics simulations of the hydrophobin SC3 at a hydrophobic/hydrophilic interface

    OpenAIRE

    Fan, Hao; Wang, Xiaoqin; Zhu, Jiang; Robillard, George T.; Mark, Alan E.

    2006-01-01

    Hydrophobins are small (similar to 100 aa) proteins that have an important role in the growth and development of mycelial fungi. They are surface active and, after secretion by the fungi, self-assemble into amphipathic membranes at hydrophobic/hydrophilic interfaces, reversing the hydrophobicity of the surface. In this study, molecular dynamics simulation techniques have been used to model the process by which a specific class I hydrophobin, SC3, binds to a range of hydrophobic/ hydrophilic i...

  18. Comparison of three microbial hosts for the expression of an active catalytic scFv.

    Science.gov (United States)

    Robin, Sylvain; Petrov, Kliment; Dintinger, Thierry; Kujumdzieva, Anna; Tellier, Charles; Dion, Michel

    2003-01-01

    Antibodies represent an interesting protein framework on which catalytic functions can be grafted. In previous studies, we have reported the characterization of the catalytic antibody 4B2 obtained on the basis of the "bait and switch" strategy which catalyzes two different chemical reactions: the allylic isomerization of beta,gamma-unsaturated ketones and the Kemp elimination. We have cloned the antibody 4B2 and expressed it as a single-chain Fv (scFv) fragment in different expression systems, Escherichia coli and two yeasts species, in order to elicit the most suitable system to study its catalytic activity. The scFv4B2 was secreted as an active form in the culture medium of Pichia pastoris and Kluyveromyces lactis, which led respectively to 4 and 1.3mg/l after purification. In E. coli, different strategies were investigated to increase the cytoplasmic soluble fraction, which resulted, in all cases, in the expression of a low amount of functional antibodies. By contrast, substantial amount of scFv4B2 could be purified when it was expressed as inclusion bodies (12mg/l) and submitted to an in vitro refolding process. Its catalytic activity was measured and proved to be comparable to that of the whole IgG. However, the instability of the scFv4B2 in solution prevented from an exhaustive characterization of its activity and stabilization of this protein appears to be essential before designing strategies to improve its catalytic activity. PMID:12531284

  19. EFFICIENCY OF USING THE HUMAN RESOURCES AT S.C. CATEX S.A.

    OpenAIRE

    Daniela CREŢU; Radu Andrei IOVA

    2012-01-01

    S.C. CATEX S.A. has being producing textile confections for over 40 years. It is a private company with integral Romanian capital, that develops its activity in the sector of textile confections, the production being destined especially to export. The economic viability of the company depends on the volume, structure and efficiency of using the material, financial and human resources. The analysis of using the human resources is approached in three aspects: as dimension and structure, sta...

  20. Solid Waste in Drainage Network of Rio do Meio Watershed, Florianópolis/SC

    OpenAIRE

    Taiana Gava; Alexandra Rodrigues Finotti

    2012-01-01

    The urban drainage network is among the main pollution transport load factors. Researches on the identification of solid waste transported in the drainage network have been considered the allow evaluation of its impact. In this paper we analyze the main characteristics that influences the presence of solid wastes in the drainage network of the Rio do Meio basin, Florianópolis/SC. A metal net was installed in selected river section and monitored after each rain event. The results showed about ...

  1. Apparent vanishing of ferroelectricity in nanostructured BiScO3PbTiO3

    OpenAIRE

    Amorín, H.; R. Jiménez; Ricote, J.; Hungría, T; de Castro, A.; Algueró, M.

    2010-01-01

    Abstract Nanostructured ceramics of high-temperature piezoelectric 0.375BiScO 3 -0.625PbTiO 3 were prepared by spark plasma sintering of nanocrystalline powders obtained by mechanosynthesis. The macroscopic electrical properties were characterized on dense ceramics with decreasing average grain size down to 28 nm. Results indicate that the electric field is screened by the electrically insulating grain boundaries at the nanoscale, which needs to be considered when discussing size effects i...

  2. Efficacy of IGR compound Starycide 480 SC (Triflumuron) against mosquito larvae in clear and polluted water

    OpenAIRE

    C.P. Batra, P.K. Mittal, T. Adak & M.A. Ansari

    2005-01-01

    Background & objectives: An environmental friendly formulation Starycide 480 SC (Triflumuron–OMS-2015 ), a new insect growth regulator with chitin synthesis inhibitor type mode of action wasevaluated against mosquito larvae in laboratory and small-scale field trials carried out in and aroundDelhi.Methods: The formulation was tested in laboratory for its bio-efficacy against late III instar mosquitolarvae of different species using WHO bioassay procedure. In the field formulation was sprayed a...

  3. Initial Permeability Dependence on the Microstructural and Compositional Changes in Ni-Zn-Sc Ferrites

    OpenAIRE

    Parvatheeswara Rao, B.; Rao, K.

    1997-01-01

    Observed variations in density, grain size and initial permeability (µic) in two series of Ni-Zn-Sc ferrites with varying concentrations of zinc and scandium have been discussed in terms of their microstructural and compositional changes. Initial amounts of scandium enhanced densification and sintering in both the series. Subsequent concentrations of only scandium caused reduction in µic in Series-I, whereas simultaneous substitutions of zinc and scandium together resulted an increase in µic ...

  4. First-principles predicted low-energy structures of NaSc(BH4)4

    OpenAIRE

    Huan, Tran Doan; Amsler, Maximilian; Botti, Silvana; Marques, Miguel A. L.; Goedecker, Stefan

    2013-01-01

    According to previous interpretations of experimental data, sodium-scandium double-cation borohydride NaSc(BH$_4$)$_4$ crystallizes in the crystallographic space group $Cmcm$ where each sodium (scandium) atom is surrounded by six scandium (sodium) atoms. A careful investigation of this phase based on \\textit{ab initio} calculations indicates that the structure is dynamically unstable and gives rise to an energetically and dynamically more favorable phase with $C222_1$ symmetry and nearly iden...

  5. Far infrared properties of the rare-earth scandate DyScO3

    OpenAIRE

    Baldassarre, L.; Perucchi, A.; Lupi, S.; Dore, P.

    2010-01-01

    We present reflectance measurements in the infrared region on a single crystal the rare earth scandate DyScO3. Measurements performed between room temperature and 10 K allow to determine the frequency of the infrared-active phonons, never investigated experimentally, and to get information on their temperature dependence. A comparison with the phonon peak frequency resulting from ab-initio computations is also provided. We finally report detailed data on the frequency dependence of the comple...

  6. An evaluation of the J and P SC60 gamma sample counter

    International Nuclear Information System (INIS)

    A report has been submitted on an evaluation of the J and P SC60 Gamma Sample Counter for use in NHS hospitals. The report includes details of the performance of the instrument as a gamma ray detector for 125I, 57Co, 51Cr, 127Cs and 59Fe and also its electrical safety. It is concluded that the equipment provides a small, reliable counting system at reasonable cost. (U.K.)

  7. Cross section measurement for 45Sc(p,γ)46Ti

    International Nuclear Information System (INIS)

    The cross section of the reaction 45Sc(p,γ)46Ti has been measured over the bombarding energy range 0.7 - 4.2 MeV. This energy range is appropriate for calculating the interaction rate in a stellar interior over the temperature range 109 - 1010K. The results are compared with predictions of the statistical model of nuclear reactions. Stellar interaction rates are calculated

  8. Validity Evidence of the Z-Test-SC for Use With Children

    OpenAIRE

    Anna Elisa de Villemor-Amaral; Pâmela Malio Pardini Pavan; Raquel Rossi Tavella; Lucila Moraes Cardoso; Fabiola Cristina Biasi

    2016-01-01

    Abstract In Brazil, there is a lack of tools to assess the children's affective and cognitive dynamics and investments are needed in research that seeks evidence of validity of some assessment tools for that public. The Zulliger test in the Comprehensive System (Zulliger-SC) evaluates the adequacy of reality perception, affects, self-perception, interpersonal relationship and cognitive processing and can be used with children, although there are few studies with this purpose in Brazil. Thus, ...

  9. Growth, emission and scintillation properties of Tb-Sc doped LuAG epitaxial films

    Czech Academy of Sciences Publication Activity Database

    Kucera, M.; Nikl, Martin; Hanus, M.; Onderišinová, Z.; Beitlerová, Alena

    2012-01-01

    Roč. 59, č. 5 (2012), 2275-2280. ISSN 0018-9499 R&D Projects: GA AV ČR KAN300100802; GA ČR GA202/08/0893 Institutional research plan: CEZ:AV0Z10100521 Keywords : garnet * liquid phase epitaxy * LuAG:TbSc * luminescence * scintillator Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.219, year: 2012

  10. Measuring social capital through multivariate analyses for the IQ-SC

    OpenAIRE

    Campos, Ana Cristina Viana; Borges, Carolina Marques; Vargas, Andréa Maria Duarte; Gomes, Viviane Elisangela; Lucas, Simone Dutra; Ferreira e Ferreira, Efigênia

    2015-01-01

    Background Social capital can be viewed as a societal process that works toward the common good as well as toward the good of the collective based on trust, reciprocity, and solidarity. Our study aimed to present two multivariate statistical analyses to examine the formation of latent classes of social capital using the IQ-SC and to identify the most important factors in building an indicator of individual social capital. Findings A cross-sectional study was conducted in 2009 among working ad...

  11. Crystal structure of boride Sc4Ni29B10 and its analogs

    International Nuclear Information System (INIS)

    The structure of boride Sc4Ni29B10 was determined by the method of X-ray diffraction analysis (sp.gr. I41/amd, a=7.680(1), c=15.382(3) A, Z=2, R=0.054). Its peculiarities and relationship with structural types of borides were considered. Isostructural borides R4Ni29B10 (R=Er, Tm, Yb, Lu) were obtained for the first time

  12. Thermodynamic modeling of the Sc2O3-MgO phase diagram

    International Nuclear Information System (INIS)

    The Sc2O3-MgO system consists of one liquid and two solid solutions. A relatively simple approach is used to model the solution phases, which are treated as the regular and the sub-regular solutions of the end-members. The solution parameters are derived from the phase equilibrium data. The thermodynamic calculations using the model allow the determination of the liquidus, solidus, solvus, and metastable liquid miscibility gap. Also the lattice stabilities of the components are evaluated.

  13. Marketing plan for a new service product - case Spain Internship SC

    OpenAIRE

    Leinonen, Annika

    2015-01-01

    This thesis was conducted for Spain Internship SC which provides global internship solutions for students and companies The purpose of the thesis was to study the marketing planning process and conduct a realistic and functioning marketing plan for the company's new service product, a study and internship program in Canada, and find the best way to promote it for Finnish students and recent graduates. The purpose was also to measure the interest of the target market towards this kind of servi...

  14. A first-principle study on the properties of a new series of quaternary Heusler alloys CoFeScZ (Z=P, As, Sb)

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Qiang; Li, Lei; Lei, Gang; Deng, Jian-Bo; Hu, Xian-Ru, E-mail: huxianru@lzu.edu.cn

    2015-04-01

    The electronic structures and magnetic properties of a new series of quaternary Heusler alloys CoFeScZ (Z=P, As, Sb) are investigated through first-principle calculations. CoFeScP is found to have half-metallic ferromagnetism with a large half-metallic gap of 0.60 eV. The results show that both CoFeScAs and CoFeScSb are nearly half-metal under the equilibrium lattice constants. The change of the properties of CoFeScAs and CoFeScSb with pressure is investigated. - Highlights: • Investigate a new series of quaternary Heusler alloys CoFeScZ (Z=P, As, Sb). • The band gap of the half-metal CoFeScP is very large. • Study the magnetic properties and electronic structure of CoFeScP under the equilibrium lattice constant. • Investigate the influence of pressure on the magnetic properties and electronic structure of CoFeScAs and CoFeScSb.

  15. Extraction of scandium from various media with triisoamyl phosphate. Communication 1. extraction of Sc and impurity metals from aqueous nitric acid solutions

    International Nuclear Information System (INIS)

    The main features of extraction of Sc from aqueous nitric acid solutions with triisoamyl phosphate (TIAP) were studied. It was shown that Sc passes into the organic phase in the form of Sc(NO3)3·3TIAP. The extraction isotherms of Sc from its aqueous HNO3 solutions and from those containing salting-out agents (LiNO3, NH4NO3) with TIAP in dodecane were obtained. The distribution factor of Sc was studied in relation to the concentrations of TIAP, salting-out agent, and HNO3. The extraction of Sc and impurity metals (Zr, Th, REE) with TIAP was studied using a tracer technique at widely varied HNO3 concentration in the aqueous phase. The separation factors of Sc from impurity metals were determined

  16. Selection of affinity-improved neutralizing human scFv against HBV PreS1 from CDR3 VH/VL mutant library.

    Science.gov (United States)

    Chen, YanMin; Bai, Yin; Guo, XiaoChen; Wang, WenFei; Zheng, Qi; Wang, FuXiang; Sun, Dejun; Li, DeShan; Ren, GuiPing; Yin, JieChao

    2016-07-01

    A CDR3 mutant library was constructed from a previously isolated anti-HBV neutralizing Homo sapiens scFv-31 template by random mutant primers PCR. Then the library was displayed on the inner membrane surface in Escherichia coli periplasmic space. Seven scFv clones were isolated from the mutant library through three rounds of screening by flow cytometry. Competition ELISA assay indicates that isolated scFv fragments show more efficient binding ability to HBV PreS1 compared with parental scFv-31. HBV neutralization assay indicated that two clones (scFv-3 and 59) show higher neutralizing activity by blocking the HBV infection to Chang liver cells. Our method provides a new strategy for rapid screening of mutant antibody library for affinity-enhanced scFv clones and the neutralizing scFvs obtained from this study provide a potential alternative of Hepatitis B immune globulin. PMID:27255707

  17. Phase separation in Al-Zr-Sc alloys: from atomic jumps to ordered precipitates growth

    International Nuclear Information System (INIS)

    Zirconium and scandium addition to aluminium alloys leads to the formation of ordered precipitates. This study aims to a better understanding of precipitation kinetics thanks to an approach combining atomic and mesoscopic models. An experimental work has been undertaken too so as to characterize by transmission electron microscopy Al3Zr kinetics of precipitation. We mainly focus on the nucleation stage and, in this purpose, an atomic model lying on a rigid lattice has been built for Al-Zr-Sc system allowing us to study precipitation with kinetic Monte Carlo simulations. While keeping the vacancy exchange mechanism for diffusion, we introduce multi-site interactions going thus beyond a simple pair interaction model, and test the influence of these interactions on kinetics of precipitation. The comparison between Monte Carlo simulations and classical nucleation theory shows that mesoscopic models can lead to a good description of the nucleation stage of Al3Zr and Al3Sc as long as the order tendency of the system has been taken into account to calculate input parameters of these models. For the ternary Al-Zr-Sc system, atomic simulations allow a better understanding of the precipitation kinetic path. It is then possible to extend the field of classical nucleation theory so as to model nucleation in a ternary alloy where the stoichiometry of the precipitates is unknown. (author)

  18. Doping of BiScO3-PbTiO3 Ceramics for Enhanced Properties

    Science.gov (United States)

    Sehirlioglu, Alp; Sayir, Ali; Dynys, Fred

    2008-01-01

    High-temperature piezoelectrics are a key technology for aeronautics and aerospace applications such as fuel modulation to increase the engine efficiency and decrease emissions. The principal challenge for the insertion of piezoelectric materials is the limitation on upper use temperature which is due to low Curie-Temperature (T(sub c) and increasing electrical conductivity. BiScO3 -PbTiO3 (BS-PT) system is a promising candidate for improving the operating temperature for piezoelectric actuators due to its high TC (>400 C). Effects of Zr and Mn doping of the BS-PT ceramics have been studied and all electrical and electromechanical properties for Sc-deficient and Ti-deficient BS- PT ceramics are reported as a function of electrical field and temperature. Donor doping with Zr and Mn (in Sc deficient compositions) increased the DC-resistivity and decreased tan at all temperatures. Resulting ceramics exhibited saturated hysteresis loops with low losses and showed no dependence on the applied field (above twice the coercive field) and measurement frequency.

  19. Mechanical, electronic, optical, thermodynamic properties and superconductivity of ScGa{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Parvin, F. [Department of Physics, Rajshahi University, Rajshahi (Bangladesh); Hossain, M.A. [Department of Physics, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902 (Bangladesh); Ali, M.S. [Department of Physics, Rajshahi University, Rajshahi (Bangladesh); Islam, A.K.M.A., E-mail: azi46@ru.ac.bd [International Islamic University Chittagong, 154/A College Road, Chittagong 4203 (Bangladesh)

    2015-01-15

    The rare occurrence of type-I superconductivity in binary system ScGa{sub 3} has experimentally been shown recently. In the present paper we study the electronic, optical, thermodynamic properties and some aspects of superconductivity of this compound using first-principles calculations. The mechanical properties like elastic constants, bulk modulus, shear modulus, Pugh's ductility index, Young's modulus, Poisson's ratio, elastic anisotropy factor, Peierls stress are calculated for the first time. The material is anisotropic and brittle. Electronic band structure, density of states, Fermi surfaces and bonding nature have also been studied. The optical functions are estimated and discussed for the first time. The high reflectivity is found in the ultraviolet regions up to ∼13 eV and thus ScGa{sub 3} can serve as a possible shielding material for ultraviolet radiation. Thermal effects on some macroscopic properties of ScGa{sub 3} are predicted using the quasi-harmonic Debye model and phonon approximation in the temperature and hydrostatic pressure in the ranges of 0–1000 K and 0–40 GPa, respectively. The calculated electron–phonon coupling constant λ=0.52 yields T{sub c}=2.6 K, which is in very good agreement with the experimentally observed value. The value of the coupling constant and the Ginzburg–Landau parameter (κ=0.09) indicate that the compound is a weak-coupled type-I rare binary BCS superconductor.

  20. Cloning, expression, purification, and characterization of LC-1 ScFv with GFP tag

    Institute of Scientific and Technical Information of China (English)

    LU Min; GONG Xing-guo; YU Hong; LI Jian-yong

    2005-01-01

    Total RNA was isolated from the hybridoma cell line (LC-1), which secretes anti-lung adenocarcinoma monoclonal antibody, and was transferred into cDNA. Based on the FR1 (framework region 1) and FR4 conserved regions of LC-I gene, the variable regions of heavy chain (Vh) and light chain (Vl) were amplified, and the Vh and modified Vl were connected to single chain Fv (ScFv) by SOE-PCR (splice overlap extension PCR). The modified ScFv was fused with green fluorescent protein (GFP)and introduced into E. coli JMi09. The fusion protein induced by IPTG (Isopropylthiogalactoside) was about 57000 on a 10%SDS-PAGE gel (10% Sds Polyacrylamide Gel Electrophoresis), and primarily manifested as inclusion bodies. The renatured protein purified by Ni-NTA Superflow resins showed ability to bind to antigen on SPC-A-1 lung adenocarcinoma. In addition, the induced host cells fluoresced bright green under 395 nm wavelength, which indicated that the expected protein with dual activity was expressed in the prokaryotic system. The ScFv with GFP tag used in this research can be applied as a new reagent to detect immunological dye, and provide a feasible way to detect adenocarcinoma in a clinical setting.

  1. Microstructural evolution in recrystallized and unrecrystallized Al–Mg–Sc alloys during superplastic deformation

    International Nuclear Information System (INIS)

    Highlights: ► Microstructural evolution of extruded Al–Mg–Sc was divided into three stages. ► Subgrain rotation and coalescence occurred in early strain hardening stage. ► Dynamic recrystallization in the middle stage resulted in strain softening. ► Grain boundary sliding and dynamic grain growth occurred in final deformation stage. ► Friction stir processed alloy remained a random grain distribution at various strains. - Abstract: The microstructural evolution of unrecrystallized (extruded) and recrystallized (friction stir processed, FSP) Al–Mg–Sc alloys during superplastic straining was investigated using electron backscatter diffraction (EBSD). The unrecrystallized structure gradually transformed into a recrystallized structure, characterized by equiaxed grains, random boundary misorientation distribution and a weak texture at high strains. This evolution was divided into three stages based on true stress–strain curves and EBSD maps, i.e. subgrain rotation and coalescence in the early stage, dynamic recrystallization in the middle stage, and grain boundary sliding (GBS) and dynamic grain growth in the final stage. By comparison, the recrystallized grains in the FSP Al–Mg–Sc maintained a random distribution during the whole deformation process, however the grain size increased significantly with increasing strain, indicating that the main deformation mechanism was always GBS and dynamic grain growth. A deformation model was proposed to explain the microstructural evolution during superplastic deformation. The microstructure with the random boundary misorientations reaches a dynamic balance because the transformation between high-angle grain boundaries and low-angle grain boundaries is equivalent.

  2. Calibration of the 46Sc sand tracer detector and it's application

    International Nuclear Information System (INIS)

    The authors describe the process and result for the calibration of radioactive 46Sc detector in details. The calibration was carried out under the hydrological conditions similar to the field test. The relation between the intensity of the scattered γ-rays and the various water depths was studied by using a 46Sc plane source. The purpose of calibration of the detector with the plane source is to determine both the detector sensitivity factor and the γ-ray absorption coefficient for san/water mixture in order to calculate the thickness of the mobile water layer by means of the count rate balance method. The relation curve between the various thicknesses of the mobile layers and count rates was studied in detailed in details by using a slab source and the uniformly mixed layers with 46Sc glass. The curve is used as the calibration curve for determining the recovery of tracking radioactive tracer in situ. The recovery of tracer shows whether the field tracer data can be used to calculate the transport sediment rate or the in fill rate of sediment

  3. Enhancement of magnetic and electrical properties in Sc substituted BiFeO{sub 3} multiferroic

    Energy Technology Data Exchange (ETDEWEB)

    Durga Rao, T.; Kumari, Asmitha; Niranjan, Manish K.; Asthana, Saket, E-mail: asthanas@iith.ac.in

    2014-09-01

    Polycrystalline BiFe{sub 1−x}Sc{sub x}O{sub 3} (x=0, 0.05, 0.1 and 0.15) compounds are prepared using solid state reaction. The XRD patterns show that all compounds are crystallized in rhombohedral structure with R3c space group. An induced weak ferromagnetism in Sc substituted BiFeO{sub 3} due to suppression of spiral modulated spin structure is revealed. In addition, a spin glass like behaviour is observed from the zero field cooled (ZFC) and field cooled (FC) magnetization curves in the low temperature region. Further, the coupling between the ferroelectric and (anti) ferromagnetic orders is evident from the appearance of anomaly in the dielectric data near the magnetic Néel temperature (373 °C). The reduction of oxygen vacancies due to Sc substitution is evident from the ac conductivity data and the suppressed anomaly in dielectric data at 220 °C. The temperature dependence of ac conductivity is consistent with correlated barrier hopping (CBH) model. The temperature dependent ac conductivity and activation energies indicate that electronic conduction, oxygen vacancies movement and creation of defects are the prime contributors to the ac conductivity in measured temperature regions. The improved magnetic and electrical properties due to the structural modification are prominent for novel device applications.

  4. Sc3B0.75C3, a novel scandium boron carbide

    International Nuclear Information System (INIS)

    A Sc-based boron carbide, Sc3B0.75C3, containing linear C-B-C chains and isolated C atoms has been synthesized by a solid-state chemical reaction route. The crystal structure was determined using the X-ray powder diffraction technique and can be assigned to represent a new structure type of rare-earth boron carbides. The tetragonal crystal structure (a=3.3315(3) A, c=7.6737(1) A, P4/mmm (No.123)) is built up from chains of [Sc10] polyhedra parallel to the c-axis and contains linear C-B-C chains. The linear C-B-C chains exhibit a short B-C bond length of 1.417(1) A. Both the X-ray powder diffraction data and high-resolution transmission electron microscopy analysis suggest the possible presence of a B vacancy and site disorder in the C-B-C chain-end sites. (orig.)

  5. Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease

    Directory of Open Access Journals (Sweden)

    J. H. Gillis

    2015-01-01

    Full Text Available Acute sickle hepatic crisis (ASHC has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease.

  6. NP-MuScL: unsupervised global prediction of interaction networks from multiple data sources.

    Science.gov (United States)

    Puniyani, Kriti; Xing, Eric P

    2013-11-01

    Inference of gene interaction networks from expression data usually focuses on either supervised or unsupervised edge prediction from a single data source. However, in many real world applications, multiple data sources, such as microarray and ISH (in situ hybridization) measurements of mRNA abundances, are available to offer multiview information about the same set of genes. We propose ISH to estimate a gene interaction network that is consistent with such multiple data sources, which are expected to reflect the same underlying relationships between the genes. NP-MuScL casts the network estimation problem as estimating the structure of a sparse undirected graphical model. We use the semiparametric Gaussian copula to model the distribution of the different data sources, with the different copulas sharing the same precision (i.e., inverse covariance) matrix, and we present an efficient algorithm to estimate such a model in the high-dimensional scenario. Results are reported on synthetic data, where NP-MuScL outperforms baseline algorithms significantly, even in the presence of noisy data sources. Experiments are also run on two real-world scenarios: two yeast microarray datasets and three Drosophila embryonic gene expression datasets, where NP-MuScL predicts a higher number of known gene interactions than existing techniques. PMID:24134391

  7. Measurement of small bowel transit time by 99Tcm-SC imaging: preliminary clinical study

    International Nuclear Information System (INIS)

    Objective: To develop a method of measuring small bowel transit time (SBTT) by 99Tcm-sulfur collide (SC) imaging and to compare with the method of added lactose in the test meal. Methods: 20 healthy volunteers and 26 patients with gastrointestinal disorders were studied. In fasting state, the subjects were asked to ingest the 99Tcm-SC labelled solid meal within 5 minutes, then the image acquisition was immediately started with SPECT. The images were acquired every 15 min during the first hour, at 30 min intervals during 2∼4 hours and hourly thereafter until 80% radioactivity had entered the colon. One week later, the same procedure of imaging with 15 g lactulose added in the test meal was performed. The regions of interest (ROIs) were taken at stomach and colon, and the SBTT was calculated by deconvolution or by subtraction of the 50% time of gastric emptying from the 50% time of colon filling. Results: 1) The mean SBTT of 20 healthy volunteers was (4.2 +- 0.5) h, oral-caecum transit time (OCTT) was (4.3 +- 0.6) h; lactulose shortened the SBTT by (1.8 +- 0.6) h; 2) 26 patients showed different results of SBTT due to their different gastrointestinal disorders bases. Conclusions: 99Tcm-SC imaging was a noninvasive and useful method to measure SBTT. The added lactulose can shorten the examination time and help to identify the time of food to the ileocecal region

  8. EMP Attachment 3 DOE-SC PNNL Site Dose Assessment Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F.

    2011-12-21

    This Dose Assessment Guidance (DAG) describes methods to use to determine the Maximally-Exposed Individual (MEI) location and to estimate dose impact to that individual under the U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Site Environmental Monitoring Plan (EMP). This guidance applies to public dose from radioactive material releases to the air from PNNL Site operations. This document is an attachment to the Pacific Northwest National Laboratory (PNNL) Environmental Monitoring Plan (EMP) and describes dose assessment guidance for radiological air emissions. The impact of radiological air emissions from the U.S. Department of Energy Office of Science (DOE-SC) PNNL Site is indicated by dose estimates to a maximally exposed member of the public, referred to as the maximally exposed individual (MEI). Reporting requirements associated with dose to members of the public from radiological air emissions are in 40 CFR Part 61.94, WAC 246-247-080, and DOE Order 458.1. The DOE Order and state standards for dose from radioactive air emissions are consistent with U.S. Environmental Protection Agency (EPA) dose standards in 40 CFR 61.92 (i.e., 10 mrem/yr to a MEI). Despite the fact that the current Contract Requirements Document (CRD) for the DOE-SC PNNL Site operations does not include the requirement to meet DOE CRD 458.1, paragraph 2.b, public dose limits, the DOE dose limits would be met when EPA limits are met.

  9. Direct laser fabrication of three dimensional components using SC420 stainless steel

    International Nuclear Information System (INIS)

    Highlights: ► The feasibility of direct laser fabrication of SC402 alloy was studied. ► Three-dimensional (3D) components with varying thicknesses can be built using DLF to near net-shape. ► The build size and orientation affects the mechanical properties. ► Hot isostatic pressing can be used to homogenise the mechanical properties. - Abstract: Direct Laser Fabrication (DLF) has been used in the fabrication of three-dimensional (3D) near net-shape metallic parts using stainless steel SC420 powder. The mechanical properties and microstructure of the as-deposited SC420 and of hot isostatically pressed DLF builds were investigated as a function of deposition direction and sample size using tensile testing, scanning electron microscopy and X-ray diffraction. The influence of the build geometry and orientation on the microstructure and the mechanical properties was also assessed. From this work, it was evident that the DLF process can produce three dimensional parts with good mechanical properties (yield strength > 1000 MPa, tensile strength > 1400 MPa, elongation > 5%), which approach the properties of wrought products

  10. ETV TEST REPORT OF MOBILE SOURCE EMISSIONS CONTROL DEVICES: LUBRIZOL ENGINE CONTROL SYSTEMS PURIFILTER SC17L

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Lubrizol Engine Control Systems Purifilter SC17L manufactured by Lubrizol Engine Control Systems. The technology is a precious and base metal, passively regenerated particulate filter...

  11. Effect of Sc and Zr on the in-plane anisotropy of Al-Mg-Mn alloy sheets

    Institute of Scientific and Technical Information of China (English)

    PENG Yongyi; YIN Zhimin; YANG Jin; DU Yuxuan

    2005-01-01

    The Al-Mg-Mn alloy sheets with and without trace Sc and Zr were investigated by means of tensile test, X-ray diffraction, optical microscope, and transmission electron microscope. The indexes of in-plane anisotropy (IIPA) of their tensile mechanical properties were calculated and their inverse pole figures were obtained by Harris method. The two alloy sheets have the same law of in-plane anisotropy and remarkable in-plane anisotropy of mechanical properties, and the IIPA of the alloy sheet with Sc and Zr is bigger than that of the alloy sheet without Sc and Zr. The relationships of the in-plane anisotropy and the anisotropy of the crystallographic texture were analyzed based on the model of monocrystal. It is the common action of the anisotropy of crystallography and microstructures that causes the in-plane anisotropy of their mechanical sotropy of the alloy sheet containing trace Sc and Zr.

  12. Over-Expression of ScMnSOD, a SOD Gene Derived from Jojoba, Improve Drought Tolerance in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-fei; ZHANG Gen-fa; SUN Wei-min; LI Ze-qin; BAI Rui-xue; LI Jing-xiao; SHI Zi-han; GENG Hong-wei; ZHENG Ying; ZHANG Jun

    2013-01-01

    Jojoba (Simmondsia chinensis) is mainly distributed in desert, and the molecular mechanisms of jojoba in response to abiotic stress still remain elusive. In this paper, we cloned and characterized a SOD gene from jojoba named as ScMnSOD, and introduced into Arabidopsis to investigate its functions of responding to drought stress. The transgenic Arabidopsis showed an improvement in drought tolerance. Moreover, under a water deifcit condition, the accumulation of reactive oxygen species (ROS) was remarkably decreased in the transgenic lines compared to the WT. Furthermore, the ScMnSOD promoter was cloned to the 5´-upstream of GUS coding region in a binary vector, and introduced into Arabidopsis. And results showed that ScMnSOD expression can be induced by drought, salt, ABA, and low temperature. In conclusion, ScMnSOD plays an important role in drought tolerance which is, at least partially, attributed to its role in ROS detoxiifcation.

  13. A 21-cm line study of NGC 5963, an SC galaxy with a low-surface brightness disk

    Science.gov (United States)

    Bosma, A.; Athanassoula, E.; van der Hulst, J. M.

    1988-06-01

    Results are presented from a detailed 21-cm line study of the Sc galaxy NGC 5963. The extent of the H I emission is found to be roughly coincident with the optical image, the latter being of much lower surface brightness than normal for Sc galaxies. The velocity field shows little deviation from axial symmetry, and the derived rotation curve is typical for Sc galaxies about twice as bright as NGC 5963. A composite mass model is presented using the observed light distribution to calculate a rotation curve for the luminous part of the galaxy (assuming a constant M/L-ratio with radius); this calculated rotation curve is compared to the observed one to derive a rotation law for a dark halo. Comparison with Sc galaxies having normal disk surface brightnesses suggests that the halo in NGC 5963 is more concentrated than in normal Scs with similar rotation curves. The origin of the low surface brightness of the disk is discussed.

  14. Hyperfine fields and magnetic momente in Laves intermetallic compounds AFe2(A=Zr, Y, Sc and Gd)

    International Nuclear Information System (INIS)

    Hyperfine fields (HFF) on impurity nuclei 27Al and 45Sc in the Laves cubic compounds ZrFe2, YFe2, ScFe2 and GdFe2 are measured by the method of pulsed nuclear magnetic resonance at 4.2 K. Using the data on 57Fe ad 27Al HFF the contributions to 57Fe HFF from local magnetic momentum of iron atoms μ0(Fe) are singled out, the values μ0(Fe) amd μ(A) are estimated. It is shown that HFF on 45Sc nuclei contain both contributions from local magnetic momentum of scandium atoms and from magnetic momenta of atoms in the nearest spheres. The contributions are evaluated for ZrFe2 and ScFe2

  15. Effects of substituting ytterbium for scandium on the microstructure and age-hardening behaviour of Al–Sc alloy

    International Nuclear Information System (INIS)

    In order to reduce the cost of Al–Sc alloys and maintain their mechanical properties, the microstructure and mechanical properties of Al–0.24 wt% Sc–0.07 wt% Yb in comparison with Al–0.28 wt% Sc alloys were studied. The aging behaviour, precipitate morphologies, precipitate coarsening and precipitation hardening of both alloys were investigated. The average diameter and the size distribution of nanoscale Al3Sc and Al3(Sc,Yb) precipitates at various aging conditions were measured. Transmission electron microscopy (TEM) and high-resolution TEM were used to deeply understand the precipitate evolution. A maximum hardness around 73 (HV30) was obtained with a precipitate diameter from 4.3 to 5.6 nm for both alloys

  16. Pt Skin Versus Pt Skeleton Structures of Pt3Sc as Electrocatalysts for Oxygen Reduction

    DEFF Research Database (Denmark)

    Johansson, Tobias Peter; Ulrikkeholm, Elisabeth Therese; Hernandez-Fernandez, Patricia;

    2014-01-01

    In order for low temperature polymer electrolyte membrane fuel cells to become economically viable Pt catalyst loading must be significantly reduced. The cathode of the polymer electrolyte membrane fuel cell, where oxygen reduction takes place, is responsible for the main activity loss. The...... development of new materials for this reaction is essential in order to increase the overall effeciency of the fuel cell. Herein, we study the effect of ultra high vacuum annealing on the structure and activity of polycrystalline Pt3Sc. Upon annealing in ultra high vacuum a Pt overlayer is formed on the...... polycrystalline Pt3Sc. The reactivity of the overlayer is probed by temperature programmed desorption of CO. The onset of CO desorption is around 130 K lower on UHV annealed Pt3Sc than on Pt(111) and the temperature of the desorption peak maximum at saturation was similar to 50 K lower on UHV annealed Pt3Sc...

  17. Near-barrier neutron transfer in reactions 3,6He + 45Sc and 3,6He + 197Au

    Science.gov (United States)

    Samarin, V. V.; Naumenko, M. A.; Penionzhkevich, Yu E.; Skobelev, N. K.; Kroha, V.; Mrazek, J.

    2016-06-01

    Experimental cross sections for formation of 196,198Au isotopes in reactions 3,6He + 197Au and cross sections for formation of 44,46Sc isotopes in reactions 3,6He + 45Sc have been analyzed. To calculate neutron transfer probabilities and cross sections the time- dependent Schrödinger equation for external neutrons of 3He, 6He, 45Sc and 197Au nuclei has been solved numerically. It is shown that the contribution of fusion and subsequent evaporation is significant in the case of reactions 3,6He + 45Sc, whereas in the case of reactions 3,6He + 197Au, it is negligible. Fusion-evaporation was taken into account using NRV evaporation code. Results of calculations demonstrate overall satisfactory agreement with experimental data.

  18. Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils.

    Science.gov (United States)

    Zhang, Yuan; Sun, Yuanhong; Huai, Yangyang; Zhang, Ying-Jiu

    2015-12-01

    Amyloid β peptide (Aβ42) is a major determinant of Alzheimer's disease (AD). In this study, we studied a novel single-chain variable fragment (scFv), AS, generated from an antibody library of AD patients, which recognized and bound specifically to medium-size amyloid β peptide (Aβ42) oligomers and immature protofibrils (25-55 kDa) and, more importantly, reduced their level by blocking their formation or inducing their disassembly. Consequently, scFv AS ameliorated or prevented their cytotoxicity and protected SH-SY5Y cells and primary cultured neurons in vitro from their damage in a concentration-dependent manner. Comparison of its cytotoxicity-inhibiting and cytotoxicity-neutralizing activities indicated that scFv AS displayed its protective effect on target cells mainly due to its cytotoxicity-inhibitory activity though it could also neutralize the cytotoxicity. We also found that scFv AS could efficiently cross the in vitro BBB model with a delivery efficiency of over 70% after a 60-min post-administration. The scFv AS was a monovalent antibody with an affinity constant (KD) of 5.5 × 10(-6) M and a binding threshold of 6.25 × 10(-4) μM for Aβ42 oligomers. The molecular docking simulations of Aβ42 to scFv AS revealed that scFv AS tends to approached Aβ42 oligomers and immature protofibrils mainly by their hydrophobic interaction and then drew Aβ42 molecule into the gap between VL and VH domains of scFv AS by hydrophilic interaction between scFv AS and the N-terminal region (residues 1-15) of Aβ42 and the hydrophobic interactions between scFv AS and the middle region (residues 20-33) of Aβ42. The combination of scFv AS with Aβ42 was realized likely through an induced-fit process. PMID:25330935

  19. Moments Of Microdiversity EGC Receivers And Macrodiversity SC Receiver Output Signal Over Gamma Shadowed Nakagami-m Multipath Fading Channel

    Science.gov (United States)

    Djordjević, Nebojša; Jaksić, Branimir S.; Matović, Ana; Matović, Marija; Smilić, Marko

    2015-11-01

    A system with macrodiversity selection combining (SC) receiver and for microdiversity equal gain combining (EGC) receivers is considered. Received signal is subjected, simultaneously to multipath fading and shadowing, resulting in signal envelope and signal power variation. Closed form expressions for moments of macrodiversity SC receiver output signal envelope are calculated. Numerical expressions are plotted to present the influences of Gamma shadowing severity and Nakagami-m severity on moments of proposed system output signal.

  20. Bullying prevention in schools by targeting cognitions, emotions, and behavior: Evaluating the effectiveness of the REBE-ViSC program.

    Science.gov (United States)

    Trip, Simona; Bora, Carmen; Sipos-Gug, Sebastian; Tocai, Ioana; Gradinger, Petra; Yanagida, Takuya; Strohmeier, Dagmar

    2015-10-01

    The effectiveness of a class-based antibullying prevention program on cognitions, emotions, and behaviors was investigated. The program consists of a cognitive-behavioral (Rational Emotive Behavioral Education; REBE) and a behavioral (Viennese Social Competence; ViSC) component. The REBE program is based on rational emotive behavioral theory and contains 9 student lessons. The ViSC program is based on social learning theory and comprises 10 student lessons. The order of the programs was experimentally manipulated. The REBE-ViSC program was implemented in 5 schools (14 classes), the ViSC-REBE program was implemented in 3 schools (9 classes), and 3 schools (11 classes) served as an untreated control group. Data were collected during 1 school year at pretest, midpoint, and posttest. Emotions (overt and internalizing anger), cognitions (learning and entitlement), and behaviors (bullying perpetration and bullying victimization) were measured with self-assessments. To examine the effectiveness of the REBE-ViSC/ViSC-REBE program, multilevel growth models were applied (time points at Level 1, individuals at Level 2, and classes at Level 3). The analyses revealed that the program effects differed depending on the order of the programs. The REBE-ViSC condition was more effective in changing negative emotions than the ViSC-REBE condition; both experimental conditions were effective in reducing dysfunctional cognitions, whereas no behavioral change was found in the 2 experimental groups when compared with the control group. To improve program effectiveness regarding behavioral changes, a multilevel whole-school approach including a teacher component is recommended. PMID:26376177

  1. The denitrification characteristics of Pseudomonas stutzeri SC221-M and its application to water quality control in grass carp aquaculture.

    Directory of Open Access Journals (Sweden)

    Bin Deng

    Full Text Available To reduce ammonium and nitrite in aquaculture water, an isolate of the denitrifying bacterium Pseudomonas stutzeri, SC221-M, was obtained. The effects of various nitrogen and carbon sources, the ratio of carbon to nitrogen and temperature on bacterial growth, denitrification rates and the expression levels of nirS and nosZ in SC221-M were studied. The following conditions were determined to be optimal for growth and denitrification in SC221-M: NaNO2 as the nitrogen source, sodium citrate as the carbon source, a carbon to nitrogen ratio range of 4-8, and a temperature range of 20-35°C. Subsequently, SC221-M and the Bacillus cereus BSC24 strain were selected to generate microbial preparations. The results showed that addition of the microbial preparations decreased various hydrochemical parameters, including total dissolved solids, ammonium, nitrite, total nitrogen and the chemical oxygen demand. Nitrogen removal rates were highest on day 9; the removal rates of BSC24, SC221-M, a mixed preparation and a 3× mixed preparation were 24.5%, 26.6%, 53.9% and 53.4%, respectively. The mixed preparation (SC221-M+BSC24 was more effective at removing nitrogen than either the SC221-M or BSC24 preparation. Roche 454 pyrosequencing and subsequent analysis indicated that the control and other groups formed separate clusters, and the microbial community structure in the water changed significantly after the addition of microbial preparations. These results indicate that the addition of microbial preparations can improve both the water quality and microbial community structure in an experimental aquaculture system. P. stutzeri strain SC221-M and its related microbial preparations are potential candidates for the regulation of water quality in commercial aquaculture systems.

  2. K2SC: Flexible systematics correction and detrending of K2 light curves using Gaussian Process regression

    Science.gov (United States)

    Aigrain, S.; Parviainen, H.; Pope, B. J. S.

    2016-04-01

    We present K2SC (K2 Systematics Correction), a PYTHON pipeline to model instrumental systematics and astrophysical variability in light curves from the K2 mission. K2SC uses Gaussian process regression to model position-dependent systematics and time-dependent variability simultaneously, enabling the user to remove both (e.g., for transit searches) or to remove systematics while preserving variability (for variability studies). For periodic variables, K2SC automatically computes estimates of the period, amplitude and evolution timescale of the variability. We apply K2SC to publicly available K2 data from campaigns 3-5 showing that we obtain photometric precision approaching that of the original Kepler mission. We compare our results to other publicly available K2 pipelines, showing that we obtain similar or better results, on average. We use transit injection and recovery tests to evaluate the impact of K2SC on planetary transit searches in K2 PDC (Pre-search Data Conditioning) data, for planet-to-star radius ratio down Rp/R⋆ = 0.01 and periods up to P = 40 d, and show that K2SC significantly improves the ability to distinguish between correct and false detections, particularly for small planets. K2SC can be run automatically on many light curves, or manually tailored for specific objects such as pulsating stars or large amplitude eclipsing binaries. It can be run on ASCII and FITS light curve files, regardless of their origin. Both the code and the processed light curves are publicly available, and we provide instructions for downloading and using them. The methodology used by K2SC will be applicable to future transit search missions such as TESS and PLATO.

  3. Preparation and performance characterization of the Fe-Ni/ScSZ cermet anode for oxidation of ethanol fuel in SOFCs

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Bo; Wang, S.R.; Liu, R.Z.; Wen, T.L. [Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS), 1295 Dingxi Road, Shanghai 200050 (China)

    2007-05-15

    An anodic cermet of Fe-Ni alloy and scandia stabilized zirconia (ScSZ) has been investigated for a solid oxide fuel cell (SOFC) running on ethanol fuel. Composite anodes having alloy compositions of 0, 12.5, 25, 37.5, 50 and 100 wt.% Ni were exposed to ethanol stream at 700 C for 12 h to demonstrate that carbon formation is greatly suppressed on the Fe-Ni alloys compared to that of pure Ni. Then the short-term stability for the cells with the Ni/ScSZ and Fe{sub 0.5}Ni{sub 0.5}/ScSZ anodes in ethanol stream at 700 C was checked over a relative long period of operation. Open circuit voltages (OCVs) increased from 1.03 to 1.1 V, and power densities increased from 120 to 460 mW cm{sup 2} as the operating temperature of a SOFC with Fe{sub 0.5}Ni{sub 0.5}/ScSZ anode was increased from 700 to 850 C in ethanol stream. Electrochemical impedance spectra (EIS) illustrated that the cell with Ni/ScSZ anode exhibits slightly less total impedance than that observed for the cell with Fe{sub 0.5}Ni{sub 0.5}/ScSZ anode. The performance of a fuel cell made with the Ni/ScSZ and Fe{sub 0.5}Ni{sub 0.5}/ScSZ anodes was tested in ethanol stream for 48 h and showed a significant decrease in polarization resistance with time. Impedance spectra of similar fuel cells suggest that small carbon deposits are formed with time and that the decrease in polarization resistance is due to enhanced electronic conductivity in the anode. (author)

  4. Testing of a paper-and-pencil Personalized Single Category Implicit Association Test (SC-IAT-P)

    OpenAIRE

    Bardin, Brigitte; Perrissol, Stéphane; Py, Jacques; Fos, Yoann; Souchon, Nicolas

    2016-01-01

    The purpose of this series of studies is to test a paper-and-pencil procedure adapted from a computerized Implicit Association Test: the SC-IAT-P (Personalized Single Category Implicit Association Test, Bardin, et al. 2014). This adaptation combines the advantages of SC-IAT (Karpinski & Steinman, 2006), IAT-P (Olson & Fazio, 2004) and paper-and-pencil IAT (Lemm, Lane, Sattler, Khan & Nosek, 2008). It is capable of measuring implicit attitude toward a single object, limits the infl...

  5. Structural characteristics of ScBx genes controlling the biosynthesis of hydroxamic acids in rye (Secale cereale L.).

    Science.gov (United States)

    Bakera, Beata; Makowska, Bogna; Groszyk, Jolanta; Niziołek, Michał; Orczyk, Wacław; Bolibok-Brągoszewska, Hanna; Hromada-Judycka, Aneta; Rakoczy-Trojanowska, Monika

    2015-08-01

    Benzoxazinoids (BX) are major secondary metabolites of gramineous plants that play an important role in disease resistance and allelopathy. They also have many other unique properties including anti-bacterial and anti-fungal activity, and the ability to reduce alfa-amylase activity. The biosynthesis and modification of BX are controlled by the genes Bx1 ÷ Bx10, GT and glu, and the majority of these Bx genes have been mapped in maize, wheat and rye. However, the genetic basis of BX biosynthesis remains largely uncharacterized apart from some data from maize and wheat. The aim of this study was to isolate, sequence and characterize five genes (ScBx1, ScBx2, ScBx3, ScBx4 and ScBx5) encoding enzymes involved in the synthesis of DIBOA, an important defense compound of rye. Using a modified 3D procedure of BAC library screening, seven BAC clones containing all of the ScBx genes were isolated and sequenced. Bioinformatic analyses of the resulting contigs were used to examine the structure and other features of these genes, including their promoters, introns and 3'UTRs. Comparative analysis showed that the ScBx genes are similar to those of other Poaceae species, especially to the TaBx genes. The polymorphisms present both in the coding sequences and non-coding regions of ScBx in relation to other Bx genes are predicted to have an impact on the expression, structure and properties of the encoded proteins. PMID:25666974

  6. K2SC: flexible systematics correction and detrending of K2 light curves using Gaussian process regression

    Science.gov (United States)

    Aigrain, S.; Parviainen, H.; Pope, B. J. S.

    2016-07-01

    We present K2SC (K2 Systematics Correction), a PYTHON pipeline to model instrumental systematics and astrophysical variability in light curves from the K2 mission. K2SC uses Gaussian Process regression to model position-dependent systematics and time-dependent variability simultaneously, enabling the user to remove both (e.g. for transit searches) or to remove systematics while preserving variability (for variability studies). For periodic variables, K2SC automatically computes estimates of the period, amplitude and evolution time-scale of the variability. We apply K2SC to publicly available K2 data from Campaigns 3-5 showing that we obtain photometric precision approaching that of the original Kepler mission. We compare our results to other publicly available K2 pipelines, showing that we obtain similar or better results, on average. We use transit injection and recovery tests to evaluate the impact of K2SC on planetary transit searches in K2 Pre-search Data Conditioning data, for planet-to-star radius ratios down to Rp/R* = 0.01 and periods up to P = 40 d, and show that K2SC significantly improves the ability to distinguish between true and false detections, particularly for small planets. K2SC can be run automatically on many light curves, or manually tailored for specific objects such as pulsating stars or large amplitude eclipsing binaries. It can be run on ASCII and FITS light-curve files, regardless of their origin. Both the code and the processed light curves are publicly available, and we provide instructions for downloading and using them. The methodology used by K2SC will be applicable to future transit search missions such as TESS and PLATO.

  7. Synthesis, microstructural characterization and optical properties of undoped, V and Sc doped ZnO thin films

    Energy Technology Data Exchange (ETDEWEB)

    Amezaga-Madrid, P.; Antunez-Flores, W.; Ledezma-Sillas, J.E.; Murillo-Ramirez, J.G.; Solis-Canto, O.; Vega-Becerra, O.E.; Martinez-Sanchez, R. [Centro de Investigacion en Materiales Avanzados S.C. and Laboratorio Nacional de Nanotecnologia, Miguel de Cervantes 120, Chihuahua, Chih., C.P. 31109 (Mexico); Miki-Yoshida, M., E-mail: mario.miki@cimav.edu.mx [Centro de Investigacion en Materiales Avanzados S.C. and Laboratorio Nacional de Nanotecnologia, Miguel de Cervantes 120, Chihuahua, Chih., C.P. 31109 (Mexico)

    2011-06-15

    Research highlights: > Undoped, V and Sc doped ZnO thin films by Aerosol Assisted Chemical Vapour Deposition. > Optimum substrate temperatures of 673 K and 623 K for Sc and V doped films. > Around one third of the dopants in solution were deposited into the films. > Crystallite and grain size decreased with the increase of dopant concentration. > Optical band gap increased from 3.29 to 3.32 eV for undoped to 7 Sc/Zn at. %. - Abstract: Many semiconductor oxides (ZnO, TiO{sub 2}, SnO{sub 2}) when doped with a low percentage of non-magnetic (V, Sc) or magnetic 3d (Co, Mn, Ni, Fe) cation behave ferromagnetically. They have attracted a great deal of interest due to the integration of semiconducting and magnetic properties in a material. ZnO is one of the most promising materials to carry out these tasks in view of the fact that it is optically transparent and has n or p type conductivity. Here, we report the synthesis, microstructural characterization and optical properties of undoped, V and Sc doped zinc oxide thin films. ZnO based thin films with additions of V and Sc were deposited by the Aerosol Assisted Chemical Vapour Deposition method. V and Sc were incorporated separately in the precursor solution. The films were uniform, transparent and non-light scattering. The microstructure of the films was characterized by Grazing Incidence X-ray Diffraction, Scanning Electron Microscopy, and Scanning Probe Microscopy. Average grain size and surface rms roughness were estimated by the measurement of Atomic Force Microscopy. The microstructure of doped ZnO thin films depended on the type and amount of dopant material incorporated. The optical properties were determined from specular reflectance and transmittance spectra. Results were analyzed to determine the optical constant and band gap of the films. An increase in the optical band gap with the content of Sc dopant was obtained.

  8. Synthesis, microstructural characterization and optical properties of undoped, V and Sc doped ZnO thin films

    International Nuclear Information System (INIS)

    Research highlights: → Undoped, V and Sc doped ZnO thin films by Aerosol Assisted Chemical Vapour Deposition. → Optimum substrate temperatures of 673 K and 623 K for Sc and V doped films. → Around one third of the dopants in solution were deposited into the films. → Crystallite and grain size decreased with the increase of dopant concentration. → Optical band gap increased from 3.29 to 3.32 eV for undoped to 7 Sc/Zn at. %. - Abstract: Many semiconductor oxides (ZnO, TiO2, SnO2) when doped with a low percentage of non-magnetic (V, Sc) or magnetic 3d (Co, Mn, Ni, Fe) cation behave ferromagnetically. They have attracted a great deal of interest due to the integration of semiconducting and magnetic properties in a material. ZnO is one of the most promising materials to carry out these tasks in view of the fact that it is optically transparent and has n or p type conductivity. Here, we report the synthesis, microstructural characterization and optical properties of undoped, V and Sc doped zinc oxide thin films. ZnO based thin films with additions of V and Sc were deposited by the Aerosol Assisted Chemical Vapour Deposition method. V and Sc were incorporated separately in the precursor solution. The films were uniform, transparent and non-light scattering. The microstructure of the films was characterized by Grazing Incidence X-ray Diffraction, Scanning Electron Microscopy, and Scanning Probe Microscopy. Average grain size and surface rms roughness were estimated by the measurement of Atomic Force Microscopy. The microstructure of doped ZnO thin films depended on the type and amount of dopant material incorporated. The optical properties were determined from specular reflectance and transmittance spectra. Results were analyzed to determine the optical constant and band gap of the films. An increase in the optical band gap with the content of Sc dopant was obtained.

  9. Mechanical Properties and Strengthening Mechanisms of Al-15 Pct B4C Composites with Sc and Zr at Elevated Temperatures

    Science.gov (United States)

    Qin, Jian; Zhang, Zhan; Chen, X.-Grant

    2016-09-01

    The mechanical properties at ambient and elevated temperatures of two Al-15 vol pct B4C composites, S40 with 0.4 wt pct Sc and SZ40 with 0.4 wt pct Sc and 0.24 wt pct Zr, are investigated during long-term thermal annealing. The presence of large B4C particles in the microscale has a moderate but stable strengthening effect on Al-B4C composites at ambient and elevated temperatures, while the precipitation of nanoscale Al3Sc and Al3(Sc, Zr) in the composite matrix provides a predominate contribution to the composite strength, which is varied by tested temperatures. The Al3Sc precipitates in S40 remain coarsening resistant at 523 K (250 °C), whereas the Al3(Sc, Zr) precipitates in SZ40 are thermally stable at 573 K (300 °C) over 2000 hours of annealing. At higher annealing temperatures (573 K (300 °C) for S40 and 623 K (350 °C) for SZ40), both Al3Sc and Al3(Sc, Zr) precipitates become coarsening with prolonged annealing time. The yield strength of S40 and SZ40 at ambient temperature decreases with the increasing precipitate size, which can be explained by the classical precipitate shearing and Orowan bypass mechanisms. At elevated temperatures [523 K to 623 K (250 °C to 350 °C)], considerably lower yield stresses are observed compared to those at ambient temperature, which invokes a dislocation climb mechanism. The predicted yield strengths at elevated temperatures by the combination of dislocation climb and Orowan models are in good agreement with the experimental data.

  10. Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.

    Science.gov (United States)

    Lewis, Patrick A; Properzi, Francesca; Prodromidou, Kanella; Clarke, Anthony R; Collinge, John; Jackson, Graham S

    2006-04-15

    According to the protein-only hypothesis of prion propagation, prions are composed principally of PrP(Sc), an abnormal conformational isoform of the prion protein, which, like its normal cellular precursor (PrP(C)), has a GPI (glycosylphosphatidylinositol) anchor at the C-terminus. To date, elucidating the role of this anchor on the infectivity of prion preparations has not been possible because of the resistance of PrP(Sc) to the activity of PI-PLC (phosphoinositide-specific phospholipase C), an enzyme which removes the GPI moiety from PrP(C). Removal of the GPI anchor from PrP(Sc) requires denaturation before treatment with PI-PLC, a process that also abolishes infectivity. To circumvent this problem, we have removed the GPI anchor from PrP(Sc) in RML (Rocky Mountain Laboratory)-prion-infected murine brain homogenate using the aspartic endoprotease cathepsin D. This enzyme eliminates a short sequence at the C-terminal end of PrP to which the GPI anchor is attached. We found that this modification has no effect (i) on an in vitro amplification model of PrP(Sc), (ii) on the prion titre as determined by a highly sensitive N2a-cell based bioassay, or (iii) in a mouse bioassay. These results show that the GPI anchor has little or no role in either the propagation of PrP(Sc) or on prion infectivity. PMID:16441239

  11. Interpretation of unexpected behavior of infrared absorption spectra of ScF3 beyond the quasiharmonic approximation

    Science.gov (United States)

    Piskunov, Sergei; Žguns, Pjotrs A.; Bocharov, Dmitry; Kuzmin, Alexei; Purans, Juris; Kalinko, Aleksandr; Evarestov, Robert A.; Ali, Shehab E.; Rocca, Francesco

    2016-06-01

    Scandium fluoride (ScF3), having cubic ReO3-type structure, has attracted much scientific attention due to its rather strong negative thermal expansion (NTE) in the broad temperature range from 10 to 1100 K. Here we use the results of diffraction and extended x-ray absorption fine-structure (EXAFS) spectroscopy to interpret the influence of NTE on the temperature dependence of infrared absorption spectra of ScF3. Original infrared absorption and EXAFS experiments in a large temperature range are presented and interpreted using ab initio lattice dynamics simulations within and beyond quasiharmonic approximations. We demonstrate that ab initio electronic structure calculations, based on the linear combination of atomic orbitals method with hybrid functionals, are able to reproduce well the experimental values of lattice parameter a0, band gap Eg, and lattice dynamics in ScF3. However, the simulations performed within quasiharmonic approximation fail to reproduce the temperature dependence of two infrared active bands due to the F-Sc-F bending (at 220 cm-1) and Sc-F stretching (at 520 cm-1) modes present in the infrared absorption spectra. To overcome this problem, an approach beyond the quasiharmonic approximation is proposed: It accounts for the negative thermal expansion of the lattice and for fluorine atom displacements due to strong F vibrational motion perpendicular to the cubic axes and allows us to explain qualitatively the temperature behavior of infrared spectra of ScF3.

  12. Anode-supported ScSZ-electrolyte SOFC with whole cell materials from combined EDTA-citrate complexing synthesis process

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Hongxia; Ran, Ran; Zhou, Wei; Shao, Zongping [State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, No. 5 Xing Mofan Road, Nanjing, JiangSu 210009 (China)

    2007-10-25

    The potential application of combined EDTA-citrate complexing process (ECCP) in intermediate-temperature solid-oxide fuel cells (IT-SOFCs) processing was investigated. ECCP-derived scandia-stabilized-zirconia (ScSZ) powder displayed low packing density, high surface area and nano-crystalline, which was ideal material for thin-film electrolyte fabrication based on dual dry pressing. A co-synthesis of NiO + ScSZ anode based on ECCP was developed, which showed reduced NiO(Ni) and ScSZ grain sizes and improved homogeneity of the particle size distribution, as compared with the mechanically mixed NiO + ScSZ anode. Anode-supported ScSZ electrolyte fuel cell with the whole cell materials synthesized from ECCP was successfully prepared. The porous anode and cathode exhibited excellent adhesion to the electrolyte layer. Fuel cell with 30 {mu}m thick ScSZ electrolyte and La{sub 0.8}Sr{sub 0.2}MnO{sub 3} cathode showed a promising maximum peak power density of 350 mW cm{sup -2} at 800 C. (author)

  13. Lanthanide-doped Na xScF 3+ x nanocrystals: Crystal structure evolution and multicolor tuning

    KAUST Repository

    Teng, Xue

    2012-05-23

    Rare-earth-based nanomaterials have recently drawn considerable attention because of their unique energy upconversion (UC) capabilities. However, studies of Sc 3+-based nanomaterials are still absent. Herein we report the synthesis and fine control of Na xScF 3+x nanocrystals by tuning of the ratio of oleic acid (OA, polar surfactant) to 1-octadecene (OD, nonpolar solvent). When the OA:OD ratio was increased from low (3:17) to high (3:7), the nanocrystals changed from pure monoclinic phase (Na 3ScF 6) to pure hexagonal phase (NaScF 4) via a transition stage at an intermediate OA:OD ratio (3:9) where a mixture of nanocrystals in monoclinic and hexagonal phases was obtained and the coexistence of the two phases inside individual nanocrystals was also observed. More significantly, because of the small radius of Sc 3+, Na xScF 3+x:Yb/Er nanocrystals show different UC emission from that of NaYF 4:Yb/Er nanocrystals, which broadens the applications of rare-earth-based nanomaterials ranging from optical communications to disease diagnosis. © 2012 American Chemical Society.

  14. Separation of cyclotron-produced 44Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin

    Science.gov (United States)

    Valdovinos, H.F.; Hernandez, R.; Barnhart, T.E.; Graves, S.; Cai, W.; Nickles, R.J.

    2014-01-01

    Significant interest in 44Sc as a radioactive synthon to label small molecules for positron emission tomography (PET) imaging has been recently observed. Despite the efforts of several research groups, the ideal 44Sc production and separation method remains elusive. Herein, we propose a novel separation method to obtain 44Sc from the proton irradiation of calcium targets based on extraction chromatography, which promises to greatly simplify current production methodologies. Using the commercially available Uranium and Tetravalent Actinides (UTEVA) extraction resin we were able to rapidly ( 80% of the activity generated at end of bombardment (EoB) in small ~1 M HCl fractions (400 μL). The chemical purity of the 44Sc eluates was evaluated through chelation with DOTA and DTPA, and by trace metal analysis using microwave induced plasma atomic emission spectrometry. The distribution coefficients (Kd) of Sc(III) and Ca(II) in UTEVA were determined in HCl medium in a range of concentrations from zero to 12.1 M The 44Sc obtained with our method proved to be suitable for the direct labeling of small biomolecules for PET imaging, with excellent specific activities and radiochemical purity. PMID:25464172

  15. Structural and electronic properties of Sc{sub x}Al{sub 1−x}N: First principles study

    Energy Technology Data Exchange (ETDEWEB)

    Berkok, Houria [Laboratoire d’analyse et d’application des rayonnements, Department of Physics, Université des Sciences et de la Technologie Mohamed Boudiaf PB 1505 El Mnaouer Oran Algeria (Algeria); Tebboune, Abdelghani, E-mail: tebbouneabdelghani@yahoo.fr [Laboratoire d’analyse et d’application des rayonnements, Department of Physics, Université des Sciences et de la Technologie Mohamed Boudiaf PB 1505 El Mnaouer Oran Algeria (Algeria); Saim, Asmaa; Belbachir, Ahmed H [Laboratoire d’analyse et d’application des rayonnements, Department of Physics, Université des Sciences et de la Technologie Mohamed Boudiaf PB 1505 El Mnaouer Oran Algeria (Algeria)

    2013-02-15

    The structural and electronic properties of Sc{sub x}Al{sub 1−x}N ternary semiconductor alloys are investigated in the rocksalt, zinc blend and wurtzite structures using the full potential linear muffin tin orbitals (FP-LMTO) method. The local density approximation (LDA) was used for the exchange and correlation energy density functional. In particular, the lattice constant, bulk modulus and band gap energies of ScN and AlN compounds and their ternary alloys Sc{sub x}Al{sub 1−x}N are calculated in rocksalt, zinc blend and wurtzite structures and discussed. A linear relationship has obtained for equilibrium lattice constants versus Sc concentration for rocksalt and zinc blend structures. The band gap is decreased with the increasing of Sc concentration in the rocksalt phase. For ZB-Sc{sub x}Al{sub 1−x}N, the band gap is the largest one at x=0.25 and changes from indirect to direct when x is more than 0.25.

  16. Density functional theory study of the adsorption and incorporation of Sc and Y on the AlN(0001) surface

    Science.gov (United States)

    González-Hernández, Rafael; González-Garcia, Alvaro; López-Perez, William

    2016-06-01

    Density functional theory (DFT) calculations were carried out in order to study the adsorption and incorporation of scandium and yttrium atoms on the AlN(0001) surface aiming to gain insight into epitaxial growth of ScxAl1-x N and YxAl1-x N layers on AlN. The adsorption energy, geometry, formation energy, band structure and density of states of Sc (and Y) adatom/AlN(0001) systems are calculated. The calculations showed that the interaction between Sc (and Y) adatom and the AlN(0001) surface is strong (~ 3.9 eV) and it prefers to adsorb on N-top site (T4). However, formation energy calculations reveal that the incorporation of Sc and Y atoms in the Al-substitutional site is energetically more favorable compared with the adsorption on the top layers, which can be attributed to the lower enthalpy of formation of ScN and YN with respect to that of AlN. The results also suggest that the Sc and Y atoms prefer to incorporate in top AlN surface layers. At full coverage, calculations show the formation of metallic ScxN and YxAl1-x N layers on the AlN polar surface over the entire range of Al chemical potentials, in agreement with experimental observations. In addition, we found that for high coverage Sc atoms couple ferromagnetically in the Al-substitutional sites on the AlN(0001) surface.

  17. Microstructure and transformation behavior of Ni24.7Ti50.3Pd25 high temperature shape-memory alloy with Sc micro-addition

    International Nuclear Information System (INIS)

    NiTiPd shape-memory alloys (SMAs) are potential functional materials for use as solid-state actuators in the temperature range 100–250 °C. The present study investigates the effect of 1.0 at.% Sc micro-addition to Ni24.7Ti50.3Pd25 alloy, Sc replacing either Ti or Ni. Results show that all the three alloys studied have stable transformation behavior on stress-free thermal cycling and hence, are suitable for cyclic actuation applications. However, the addition of Sc to NiTiPd alloy leads to decrease of transformation temperatures, the magnitude of decrease being greater for the alloy with Sc replacing Ni. The martensite finish (Mf) temperature of 181 °C for the NiTiPd alloy decreased to 139 °C for Sc replacing Ti and 83 °C for Sc replacing Ni. Also, the indentation modulus of NiTiPdSc (Sc replacing Ni) alloy is found to be significantly low compared to the other alloys. Analysis indicates that the observed differences in the alloy properties are related to the solubility of Sc in the NiTiPd matrix. While the quaternary NiTiPdSc alloy, Sc replacing Ti, has a single phase microstructure, the alloy with Sc replacing Ni shows the presence of Sc-rich and TiPd-type second phases in the microstructure. TEM examination revealed that the TiPd-type phase has a distinct rod-like morphology (30–50 nm) arranged in a grid-like structure. The transformation and indentation behavior of the alloys is elucidated using thermodynamic calculations of frictional energy and an electronic structure based analysis. - Highlights: • TEM of Ni23.7Ti50.3Pd25Sc1 showed distinct grid of TiPd-type phase nanorods < 50 nm. • Stress-free thermal cycling of all the three alloys showed stable transformation behavior. • Ni24.7Ti49.3Pd25Sc1 and Ni23.7Ti50.3Pd25Sc1 showed single and multiphase structures. • Sc micro-addition (1 at.%) to Ni24.7Ti50.3Pd25 alloy decreased TTs significantly. • Ni23.7Ti50.3Pd25Sc1 exhibited lower modulus of 67 GPa to 85 GPa of Ni24.7Ti50.3Pd25

  18. The consistency of the data for neutron fission averaged cross-sections of threshold reactions: A study on the cross-section of 46Ti(n,p)46Sc, 47Ti(n,p)47Sc, 48Ti(n,p)48Sc and 64Zn(n,p)64Cu reactions

    International Nuclear Information System (INIS)

    The consistency of the published values for fission averaged cross-sections of threshold reactions induced in a nuclear reactor is analyzed. The influence of the literature data involved in the determination of these cross-sections is discussed. Renormalizations based on cross-sections value for the standard reactions, isotopic abundances of the precursors and radiation emission probabilities of the radionuclide under study and the monitor, are applied to the evaluation of the cross-sections for the reactions: 46Ti(n,p)46Sc; 47Ti(n,p)47Sc; 48Ti(n,p)48Sc; and 64Zn(n,p)64Cu. - Highlights: • Some published data on cross-sections averaged over a fission spectrum are analyzed. • The reactions were 46Ti(n,p)46Sc; 47Ti(n,p)47Sc; 48Ti(n,p)48Sc and 64Zn(n,p)64Cu. • Renormalization as a function of five critical parameters was performed. • Averages of the renormalized values were calculated and the results discussed

  19. Single crystal CrN/ScN superlattice soft X-ray mirrors: Epitaxial growth, structure, and properties

    International Nuclear Information System (INIS)

    Single crystal CrN/ScN superlattice films with modulation periods of 1.64 nm were grown on MgO(001) substrates. By utilizing a magnetically enhanced plasma in the vicinity of the substrate and a negative substrate bias, ion/metal nitride flux ratios of 45 and 144 were achieved during deposition of CrN and ScN, respectively. The effects of ion energies in the range [16-58 eV] and substrate temperatures in the range [535-853 deg. C] on the composition, interface width, crystal quality, and microstructure evolution were investigated using elastic recoil detection analysis, hard X-ray reflectivity, X-ray diffraction, and transmission electron microscopy (TEM). Minimal interface widths of 0.2 nm = 1/2 nitride unit cell were achieved at a growth temperature of 735 deg. C and ion energies of 24 and 28 eV for CrN and ScN, respectively. Under these conditions, also an optimum in the crystal quality was observed for near stoichiometric composition of CrN and ScN. TEM confirmed a cube-on-cube epitaxial relationship for the system with CrN(001) ScN(001) MgO(001) and CrN[100] ScN[100] MgO[100]. Also, the layers were coherently strained to each other with no misfit dislocations, threading dislocations, surface cusps, voids or gas bubbles present. Higher ion energies or lower deposition temperatures gave over-stoichiometric films with poor superlattice modulation while higher growth temperatures yielded a decreased crystal quality, due to loss of N. As-deposited superlattices with only 61 periods exhibited an absolute soft X-ray reflectance of 6.95% at an energy of 398.8 eV (Sc 2p-absorption edge) which is comparable to the performance of Cr/Sc. The compositional modulation and phase structure was stable during extended annealing at 850 deg. C, which is the highest thermal stability for an X-ray multilayer mirror. It is concluded that the ScN layers serve as effective diffusion barriers to hinder decomposition of the CrN layers and stabilize the pseudomorphic superlattice

  20. The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine.

    Science.gov (United States)

    Jain, Saurabh; Aresu, Luca; Comazzi, Stefano; Shi, Jianguo; Worrall, Erin; Clayton, John; Humphries, William; Hemmington, Sandra; Davis, Paul; Murray, Euan; Limeneh, Asmare A; Ball, Kathryn; Ruckova, Eva; Muller, Petr; Vojtesek, Borek; Fahraeus, Robin; Argyle, David; Hupp, Ted R

    2016-01-01

    Monoclonal antibodies are leading agents for therapeutic treatment of human diseases, but are limited in use by the paucity of clinically relevant models for validation. Sporadic canine tumours mimic the features of some human equivalents. Developing canine immunotherapeutics can be an approach for modeling human disease responses. Rituximab is a pioneering agent used to treat human hematological malignancies. Biologic mimics that target canine CD20 are just being developed by the biotechnology industry. Towards a comparative canine-human model system, we have developed a novel anti-CD20 monoclonal antibody (NCD1.2) that binds both human and canine CD20. NCD1.2 has a sub-nanomolar Kd as defined by an octet red binding assay. Using FACS, NCD1.2 binds to clinically derived canine cells including B-cells in peripheral blood and in different histotypes of B-cell lymphoma. Immunohistochemical staining of canine tissues indicates that the NCD1.2 binds to membrane localized cells in Diffuse Large B-cell lymphoma, Marginal Zone Lymphoma, and other canine B-cell lymphomas. We cloned the heavy and light chains of NCD1.2 from hybridomas to determine whether active scaffolds can be acquired as future biologics tools. The VH and VL genes from the hybridomas were cloned using degenerate primers and packaged as single chains (scFv) into a phage-display library. Surprisingly, we identified two scFv (scFv-3 and scFv-7) isolated from the hybridoma with bioactivity towards CD20. The two scFv had identical VH genes but different VL genes and identical CDR3s, indicating that at least two light chain mRNAs are encoded by NCD1.2 hybridoma cells. Both scFv-3 and scFv-7 were cloned into mammalian vectors for secretion in CHO cells and the antibodies were bioactive towards recombinant CD20 protein or peptide. The scFv-3 and scFv-7 were cloned into an ADEPT-CPG2 bioconjugate vector where bioactivity was retained when expressed in bacterial systems. These data identify a recombinant anti-CD20

  1. Theoretical Insight into Sc2O@C84: Interplay between Small Cluster and Large Carbon Cage.

    Science.gov (United States)

    Guo, Yi-Jun; Zhao, Xiang; Zhao, Pei; Yang, Tao

    2015-10-15

    Very recently, a series of endohedral fullerenes Sc2O@C2n (n = 35-47) were facilely produced. However, only two of them have been further characterized so far. Theoretically, we studied another discandium oxide endohedral fullerene without any characterizations, Sc2O@C84, which is the second most-abundant species in terms of relative heights of all mass spectrum peaks. Two thermodynamically stable isomers with isolated pentagon rule-obeying cages were found, namely, Sc2O@C2v(51575)-C84 and Sc2O@C1(51580)-C84. This is the first case that an endohedral fullerene containing the C2v(51575)-C84 cage acts as the lowest-energy isomer, and it is the first report of a clusterfullerene containing the C1(51580)-C84 cage. The endohedral Sc2O cluster can keep its ideal structure after encapsulation, while both C84 cages have deformed dramatically. Orbital analysis suggests that nucleophilic and oxidization reactions of both isomers should take place on the cage, while regioselectivity of Sc2O@C2v(51575)-C84 and Sc2O@C1(51580)-C84 is different due to their different characteristics of the highest occupied orbital distribution. Two-dimensional electron localization function and Laplacian of electron density maps unambiguously indicate strong electrostatic interactions exist between one scandium atom and the oxygen one. Meanwhile, overlaps of occupied metal atom orbitals and the cage ones along with Mayer bond order analysis identify that covalent interactions between a scandium atom and each C84 cage cannot be neglected. At last, (13)C NMR, UV-vis-NIR, and IR spectra of both Sc2O@C84 isomers were simulated theoretically. Because of their structural difference, all spectra between two isomers are significantly divergent. Consequently, these spectra are helpful to distinguish Sc2O@C2v(51575)-C84 and Sc2O@C1(51580)-C84 in further experimental characterizations. PMID:26390279

  2. The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

    Science.gov (United States)

    Jain, Saurabh; Aresu, Luca; Comazzi, Stefano; Shi, Jianguo; Worrall, Erin; Clayton, John; Humphries, William; Hemmington, Sandra; Davis, Paul; Murray, Euan; Limeneh, Asmare A.; Ball, Kathryn; Ruckova, Eva; Muller, Petr; Vojtesek, Borek; Fahraeus, Robin; Argyle, David; Hupp, Ted R.

    2016-01-01

    Monoclonal antibodies are leading agents for therapeutic treatment of human diseases, but are limited in use by the paucity of clinically relevant models for validation. Sporadic canine tumours mimic the features of some human equivalents. Developing canine immunotherapeutics can be an approach for modeling human disease responses. Rituximab is a pioneering agent used to treat human hematological malignancies. Biologic mimics that target canine CD20 are just being developed by the biotechnology industry. Towards a comparative canine-human model system, we have developed a novel anti-CD20 monoclonal antibody (NCD1.2) that binds both human and canine CD20. NCD1.2 has a sub-nanomolar Kd as defined by an octet red binding assay. Using FACS, NCD1.2 binds to clinically derived canine cells including B-cells in peripheral blood and in different histotypes of B-cell lymphoma. Immunohistochemical staining of canine tissues indicates that the NCD1.2 binds to membrane localized cells in Diffuse Large B-cell lymphoma, Marginal Zone Lymphoma, and other canine B-cell lymphomas. We cloned the heavy and light chains of NCD1.2 from hybridomas to determine whether active scaffolds can be acquired as future biologics tools. The VH and VL genes from the hybridomas were cloned using degenerate primers and packaged as single chains (scFv) into a phage-display library. Surprisingly, we identified two scFv (scFv-3 and scFv-7) isolated from the hybridoma with bioactivity towards CD20. The two scFv had identical VH genes but different VL genes and identical CDR3s, indicating that at least two light chain mRNAs are encoded by NCD1.2 hybridoma cells. Both scFv-3 and scFv-7 were cloned into mammalian vectors for secretion in CHO cells and the antibodies were bioactive towards recombinant CD20 protein or peptide. The scFv-3 and scFv-7 were cloned into an ADEPT-CPG2 bioconjugate vector where bioactivity was retained when expressed in bacterial systems. These data identify a recombinant anti-CD20

  3. Humoral immune responses induced by anti-idiotypic antibody fusion protein of 6B11scFv/hGM-CSF in BALB/c mice

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Background We have previously developed and characterized a monoclonal anti-idiotype antibody, designated 6B11, which mimics an ovarian carcinoma associated antigen OC166-9 and whose corresponding monoclonal antibody is COC166-9 (Ab1). In this study, we evaluate the humoral immune responses induced by the fusion protein 6B11 single-chain variable fragment (scFv)/human granulocyte macrophage colony-stimulating factor (hGM-CSF) and 6B11scFv in BALB/c mice. Methods The fusion protein 6B11scFv/hGM-CSF was constructed by fusing a recombinant single-chain variable fragment of 6B11scFv to GM-CSF. BALB/c mice were administrated by 6B11scFv/hGM-CSF and 6B11scFv, respectively. Results The fusion protein 6B11scFv/hGM-CSF retained binding to the anti-mouse F(ab)2' and was also biologically active as measured by proliferation of human GM-CSF dependent cell TF1 in vitro. After immunization with the 6B11scFv/hGM-CSF and 6B11ScFv, BALB/c mice showed significantly enhanced Ab3 antibody responses to 6B11scFv/hGM-CSF compared with the 6B11scFv alone. The level of Ab3 was the highest after the first week and maintained for five weeks after the last immunization. Another booster was given when the Ab3 titer descended, and it would reach to the high level in a week. Conclusion The fusion protein 6B11scFv/hGM-CSF can induce humoral immunity against ovarian carcinoma in vivo. We also provide the theoretical foundation for the application of the fusion protein 6B11scFv/hGM-CSF for active immunotherapy of ovarian cancer.

  4. Inauguration SC

    CERN Multimedia

    Jentschke,W; Wilkinson

    1975-01-01

    Le DG W.Jentschke ouvre l'inauguration du Syncro Cyclotron (8') et remercie Mons. Michaelis qui prend la parole (30') avant Mons. Wilkinson (53') qui parle du futur de la machine avec présentation des dias.

  5. Issues associated with the metalorganic chemical vapor deposition of ScGaN and YGaN alloys.

    Energy Technology Data Exchange (ETDEWEB)

    Koleske, Daniel David; Knapp, James Arthur; Lee, Stephen Roger; Crawford, Mary Hagerott; Creighton, James Randall; Cross, Karen Charlene; Thaler, Gerald

    2009-07-01

    The most energy efficient solid state white light source will likely be a combination of individually efficient red, green, and blue LED. For any multi-color approach to be successful the efficiency of deep green LEDs must be significantly improved. While traditional approaches to improve InGaN materials have yielded incremental success, we proposed a novel approach using group IIIA and IIIB nitride semiconductors to produce efficient green and high wavelength LEDs. To obtain longer wavelength LEDs in the nitrides, we attempted to combine scandium (Sc) and yttrium (Y) with gallium (Ga) to produce ScGaN and YGaN for the quantum well (QW) active regions. Based on linear extrapolation of the proposed bandgaps of ScN (2.15 eV), YN (0.8 eV) and GaN (3.4 eV), we expected that LEDs could be fabricated from the UV (410 nm) to the IR (1600 nm), and therefore cover all visible wavelengths. The growth of these novel alloys potentially provided several advantages over the more traditional InGaN QW regions including: higher growth temperatures more compatible with GaN growth, closer lattice matching to GaN, and reduced phase separation than is commonly observed in InGaN growth. One drawback to using ScGaN and YGaN films as the active regions in LEDs is that little research has been conducted on their growth, specifically, are there metalorganic precursors that are suitable for growth, are the bandgaps direct or indirect, can the materials be grown directly on GaN with a minimal defect formation, as well as other issues related to growth. The major impediment to the growth of ScGaN and YGaN alloys was the low volatility of metalorganic precursors. Despite this impediment some progress was made in incorporation of Sc and Y into GaN which is detailed in this report. Primarily, we were able to incorporate up to 5 x 10{sup 18} cm{sup -3} Y atoms into a GaN film, which are far below the alloy concentrations needed to evaluate the YGaN optical properties. After a no-cost extension was

  6. Development of single chain variable fragment (scFv) antibodies against surface proteins of 'Ca. Liberibacter asiaticus'.

    Science.gov (United States)

    Yuan, Qing; Jordan, Ramon; Brlansky, Ronald H; Minenkova, Olga; Hartung, John

    2016-03-01

    'Candidatus Liberibacter asiaticus' is the causal agent of citrus huanglongbing, the most serious disease of citrus worldwide. We have developed and applied immunization and affinity screening methods to develop a primary library of recombinant single chain variable fragment (scFv) antibodies in an M13 vector, pKM19. The antibody population is enriched for antibodies that bind antigens of 'Ca. Liberibacter asiaticus'. The primary library has more than 10(7) unique antibodies and the genes that encode them. We have screened this library for antibodies that bind to specifically-chosen proteins that are present on the surface of 'Ca. Liberibacter asiaticus'. These proteins were used as targets for affinity-based selection of scFvs that bind to the major outer membrane protein, OmpA; the polysaccharide capsule protein KpsF; a protein component of the type IV pilus (CapF); and, two flagellar proteins FlhA and FlgI. These scFvs have been used in ELISA and dot blot assays against purified protein antigens and 'Ca. Liberibacter asiaticus' infected plant extracts. We have also recloned many of these scFvs into a plasmid expression vector designed for the production of scFvs. Screening of these scFvs was more efficient when phage-bound, rather than soluble scFvs, were used. We have demonstrated a technology to produce antibodies at will and against any protein target encoded by 'Ca. Liberibacter asiaticus'. Applications could include advanced diagnostic methods for huanglongbing and the development of immune labeling reagents for in planta applications. PMID:26744234

  7. Effects of trace Be and Sc addition on the thermal stability of Al–7Si–0.6Mg alloys

    Energy Technology Data Exchange (ETDEWEB)

    Tzeng, Yu-Chih [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China); Wu, Chih-Ting [Department of Vehicle Engineering, Army Academy R.O.C., Jhongli, Taiwan (China); Yang, Cheng-Hsien [Institute of Materials Science and Engineering, National Central University, Jhongli, Taiwan (China); Lee, Sheng-Long, E-mail: shenglon@cc.ncu.edu.tw [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China)

    2014-09-22

    In the present study, the effects of trace amounts of beryllium (Be, 0.05 wt%) and scandium (Sc, 0.04 wt%) addition on the microstructures and thermal stability of Al–7Si–0.6Mg alloys were investigated. The results show that traces of Be and Sc significantly reduce the amount of the iron-bearing phase and the interdendritic shrinkage. Be transformed the acicular iron-bearing phases into the nodular Al–Fe–Si iron-bearing phase, which is less harmful to ductility. Moreover, the addition of Be increased the Mg content of the solid solution within the matrix, prompting greater precipitation of the metastable Mg{sub 2}Si phase after T6 heat treatment and effectively enhancing the mechanical properties of the alloy. However, during the following thermal exposure at 250 °C for 100 h, the metastable Mg{sub 2}Si phase grew into the coarse β-Mg{sub 2}Si equilibrium phase, resulting in a decrease in the mechanical strength of the alloy. Meanwhile, the addition of Sc had insignificant effect on the amount of metastable Mg{sub 2}Si phase that precipitated. However, here, the iron-bearing phase was a nodular Al{sub 12}Si{sub 6}Fe{sub 2}(Mg,Sc){sub 5} phase, which significantly enhanced the density of the castings. After the same thermal exposure procedure, it was remarkably found that the precipitation of fine Al{sub 3}Sc particles effectively inhibited grain growth and hindered the movement of dislocations. These factors led to the Sc-containing alloy having better mechanical properties (strength and ductility) than the alloys without Sc or with Be during the following thermal exposure at 250 °C.

  8. 44Sc-DOTA-BN[2-14]NH2 in comparison to 68Ga-DOTA-BN[2-14]NH2 in pre-clinical investigation. Is 44Sc a potential radionuclide for PET?

    International Nuclear Information System (INIS)

    Aim: In the present study we demonstrate the in vitro and in vivo comparison of the 44Sc and 68Ga labeled DOTA-BN[2-14]NH2. 44Sc is a positron emitter with a half life of 3.92 h. Hence it could be used for PET imaging with ligands requiring longer observation time than in the case of 68Ga. Methods: The binding affinity of natSc-DOTA-BN[2-14]NH2 and natGa-DOTA-BN[2-14]NH2 to GRP receptors was studied in competition to [125I-Tyr4]-Bombesin in the human prostate cancer cell line PC-3. A preliminary biodistribution in normal rats was performed, while first microPET images were assessed in male Copenhagen rats bearing the androgen-independent Dunning R-3327-AT-1 prostate cancer tumor. Results: The affinity to GRP receptors in the PC-3 cell line was higher for natGa-DOTA-BN[2-14]NH2 (IC50(nM)=0.85±0.06) than that of natSc-DOTA-BN[2-14]NH2 (IC50 (nM)=6.49±0.13). The internalization rate of 68Ga labeled DOTA-BN[2-14]NH2 was slower than that of 44Sc, but their final internalization percents were comparable. 68Ga-DOTA-BN[2-14]NH2 was externalized faster than 44Sc-DOTA-BN[2-14]NH2. The biodistribution of 44Sc-DOTA-BN[2-14]NH2 and 68Ga-DOTA-BN[2-14]NH2 in normal rats revealed a higher uptake in target organs and tissues of the first one while both excreted mainly through urinary tract. In microPET images both tracers were accumulated in the tumor with similar uptake patterns. Conclusions: Despite the differences in the receptor affinity both the 68Ga- and the 44Sc-labeled DOTA-BN[2-14]NH2 tracers showed comparable distribution and similar time constants of uptake and elimination. Moreover no differences in tumor accumulation (neither in the overall uptake nor in the dynamics) were observed from the microPet imaging. From that perspective the use of either 44Sc or 68Ga for detecting tumors with GRP receptors is equivalent. - Highlights: ► In vitro and in vivo evaluation of 44Sc- and 68Ga-DOTA-BN[2-14]NH2 in reference to published data. ► Higher in vitro affinity to GRP

  9. Preparation of a Chicken scFv to Analyze Gentamicin Residue in Animal Derived Food Products.

    Science.gov (United States)

    Li, Cui; He, Jinxin; Ren, Hao; Zhang, Xiaoying; Du, Enqi; Li, Xinping

    2016-04-01

    Chicken is an ideal model for simplified recombinant antibody library generation. It has been rarely been reported to apply chicken single-chain variable fragments (scFvs) in immunoassays for the detection of antibiotic and chemical contaminants in animal food products. In this study, the scFvs (S-1 and S-5) were isolated from a phage display library derived from a hyperimmunized chicken. The checker board titration revealed that the optimum concentrations of S-1 and S-5 were 0.78 μg/mL and 0.44 μg/mL respectively, to obtain OD450 around 1.0 at 5 μg/mL of Gent-OVA coating concentration. Both S-1 and S-5 exhibited negligible cross reactivity with kanamycin and amikacin. The 50% inhibitory concentration (IC50) of S-1 and S-5 were 12.418 ng/mL and 14.674 ng/mL respectively. In the indirect competitive ELISA (ic-ELISA), the limits of detection for S-1 and S-5 were 0.147 ng/mL and 0.219 ng/mL respectively. The mean recovery for Gent ranged from 60.91% to 118.09% with no more than 10.35% relative standard deviation (RSD) between the intra-assay and the inter-assay. These results indicate the chicken scFv based ic-ELISA method is suitable for the detection of Gent residue in animal derived edible tissues and milk. PMID:26980703

  10. Radiation-Resistant Micrococcus luteus SC1204 and Its Proteomics Change Upon Gamma Irradiation.

    Science.gov (United States)

    Deng, Wuyuan; Yang, Yang; Gao, Peng; Chen, Hao; Wen, Wenting; Sun, Qun

    2016-06-01

    To explore the radiation-resistance mechanisms in bacteria, a radiation-resistant strain SC1204 was isolated from the surrounding area of a (60)Co-γ radiation facility. SC1204 could survive up to 8 kGy dose of gamma irradiation and was identified as Micrococcus luteus by phylogenetic analysis of 16S rRNA gene sequences. Its proteomic changes under 2-kGy irradiation were examined by two-dimensional electrophoresis followed by MALDI-TOF-TOF/MS analysis. The results showed that at least 24 proteins displayed significant changes (p radiation stress, among which 22 were successfully identified and classified into the major functional categories of metabolism, energy production and conservation, translation, ribosomal structure, and biogenesis. Among these proteins, leucyl aminopeptidase involved in synthesis of glutathione was the most abundant induced protein during postirradiation recovery, indicating that anti-oxidation protection was the most important line of defense in SC1204 against radiation. The next abundant protein was phosphoribosyl aminoimidazole carboxamide formyltransferase/IMP cyclohydrolase (AICAR Tfase/IMPCH), the key enzyme in the biosynthetic pathway of purine that is anti-radiation compound. Other proteins changing significantly (p radiation exposure included urocanate hydratase, dihydrolipoyl dehydrogenase, succinyl-CoA synthetase subunit alpha, phosphoglycerate kinase, cell division protein FtsZ, elongation factor Ts and Tu, translation elongation factor Tu and G, 30S ribosomal protein S1, histidyl-tRNA synthetase, and arginyl-tRNA synthetase, which were considered to be the key proteins in urocanate metabolism, tricarboxylic acid cycle, glycolysis, cell division process, and synthesis process of proteins. Therefore, these proteins may also play important roles in radiation resistance in M. luteus. PMID:26920868

  11. Scénariser l’apprentissage, une activité de modélisation

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Pernin

    2007-01-01

    Full Text Available [Français] Un regard sur la scénarisation pédagogique: Depuis le début des années 2000, un ensemble de travaux de recherche et d’initiatives de terrain visent à proposer ou à utiliser des modèles, des méthodes et des outils pour concevoir, mettre en place, exploiter et analyser les scénarios d’apprentissage. Sur le plan international, on peut citer en particulier les travaux menés par Koper et Tattersall, (2005 portant sur les langages de modélisation pédagogique et plus spécifiquement autour de la proposition IMS (Instructional Management System Learning Design ainsi que ceux de Paquette (2006 conduisant à développer une approche en ingénierie éducative supportant le développement d’environnements d’apprentissage en ligne. Ces travaux ont contribué à faire émerger, au sein des communautés éducatives, le concept de scénario pédagogique comme un composant essentiel des systèmes d’apprentissage en ligne. Le but poursuivi par ces chercheurs et leurs équipes est « d’explorer comment améliorer la qualité pédagogique des cours en ligne, dans une voie interopérable, avec les outils d’usage facile ».

  12. Microstructural evolution in recrystallized and unrecrystallized Al-Mg-Sc alloys during superplastic deformation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, F.C.; Xue, P. [Shenyang National Laboratory of Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China); Ma, Z.Y., E-mail: zyma@imr.ac.cn [Shenyang National Laboratory of Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer Microstructural evolution of extruded Al-Mg-Sc was divided into three stages. Black-Right-Pointing-Pointer Subgrain rotation and coalescence occurred in early strain hardening stage. Black-Right-Pointing-Pointer Dynamic recrystallization in the middle stage resulted in strain softening. Black-Right-Pointing-Pointer Grain boundary sliding and dynamic grain growth occurred in final deformation stage. Black-Right-Pointing-Pointer Friction stir processed alloy remained a random grain distribution at various strains. - Abstract: The microstructural evolution of unrecrystallized (extruded) and recrystallized (friction stir processed, FSP) Al-Mg-Sc alloys during superplastic straining was investigated using electron backscatter diffraction (EBSD). The unrecrystallized structure gradually transformed into a recrystallized structure, characterized by equiaxed grains, random boundary misorientation distribution and a weak texture at high strains. This evolution was divided into three stages based on true stress-strain curves and EBSD maps, i.e. subgrain rotation and coalescence in the early stage, dynamic recrystallization in the middle stage, and grain boundary sliding (GBS) and dynamic grain growth in the final stage. By comparison, the recrystallized grains in the FSP Al-Mg-Sc maintained a random distribution during the whole deformation process, however the grain size increased significantly with increasing strain, indicating that the main deformation mechanism was always GBS and dynamic grain growth. A deformation model was proposed to explain the microstructural evolution during superplastic deformation. The microstructure with the random boundary misorientations reaches a dynamic balance because the transformation between high-angle grain boundaries and low-angle grain boundaries is equivalent.

  13. Fundamental studies of H2 interaction with MAl3 clusters [M = Li, Sc, Ti, Zr

    International Nuclear Information System (INIS)

    Highlights: • A first-principles calculation on H2 interaction and saturation on stable MAl3 clusters [M = Li, Sc, Ti, Zr] is performed. • Transition metals have negative electron charge density while Al atom has positive in MAl3 from NBO charge analysis. • H2 undergoes dissociative chemisorption on the M atop site resulting in M–H–Al bridge bond. • H2 saturation on M atop site results initially chemisorption and then physisorption with 3-centered Kubas interaction. • External electric field applied on TiAl3H4 leads to more polarization, H2 bond elongation and increased adsorption energy. -- Abstract: Complex metal hydride is a promising hydrogen storage material for automobile applications due to its reversible storage capacity. The presence of transition metal halide is found to improve significantly the kinetics of H2 adsorption and desorption processes. Experimental studies have indicated the formation of distorted MAl3 phase where M = Sc, Ti, Zr. In this study, a first-principles density functional study has been performed to investigate the hydrogen interaction and saturation on stable tetrahedral MAl3 clusters [M = Li, Sc, Ti, and Zr] by employing spin-polarized hybrid and non-local density functionals. On saturation, the first H2 molecule undergoes chemisorption in the transition metals while further loading results in physisorption with the Kubas-type H2 interaction. Activation energy barrier for the H2 dissociation over the cluster is calculated to be ∼0.2 eV for the transition metals. Effect of external electric field on the MAl3H4 cluster with molecular H2 is studied which leads to polarization of physisorbed H2 and the cluster. The results offer an explanation for catalysts role in improving the kinetics of H2 sorption process in complex metal hydrides

  14. Spark plasma sintering of a nanocrystalline Al-Cu-Mg-Fe-Ni-Sc alloy

    Science.gov (United States)

    Zúñiga, Alejandro; Ajdelsztajn, Leonardo; Lavernia, Enrique J.

    2006-04-01

    The microstructure and aging behavior of a nanocrystalline Al-Cu-Mg-Fe-Ni-Sc alloy was studied. The nanocrystalline powders were produced by milling at liquid nitrogen temperature and then consolidated using spark plasma sintering (SPS). The microstructure after SPS consisted of a bimodal aluminum grain structure (coarse-grained and fine-grained regions), along with Al9FeNi and Al2CuMg particles dispersed throughout. The microstructure observed in the as-consolidated sample is rationalized on the basis of high current densities that are generated during sintering. Solution treatment and aging of the SPS Al-Cu-Mg-Fe-Ni-Sc sample resulted in softening instead of hardening. This observation can be explained by the reduced amount of Cu, Mg, and Si in solid solution available to form S' Al2CuMg due to the precipitation of Al7FeCu2 and Si-rich particles, and by the fact that rodlike S' Al2CuMg particles could only precipitate out in the coarse-grained regions, greatly decreasing their influence on the hardness. This lack of precipitation in the fine-grained region is argued to represent a new physical observation and is rationalized on the basis of physical and thermodynamic effects. The nanocrystalline SPS Al-Cu-Mg-Fe-Ni-Sc sample was also extremely thermally stable, retaining a fine-grained structure even after solution treatment at 530°C for 5 h. The observed thermal stability is rationalized on the basis of solute drag and Zener pinning caused by the impurities introduced during the cryomilling process.

  15. Nuclear spectroscopy of 24Na and 46Sc by thermal neutron capture

    International Nuclear Information System (INIS)

    The measurement of the intensity and the energy of γ-rays produced by capture of thermal neutrons in 45Sc is reported. Of the total primary transition strength 99% could be accounted for and 426 lines could be placed in a 46Sc level scheme containing 27 previously unobserved levels. The reaction Q-value was determined as 8760.77. Of the 158 γ-rays ascribed to the 23Na(n,γ)24Na reaction, 143 have been placed in a 24Na decay scheme accounting for 100% of the total primary strength. The reaction Q-value amounts to 6959.42. The data resulted in spin assignments for four and spin restrictions for six levels. The circular polarization of 14 γ-rays from the capture of polarized neutrons has been measured. The Jsup(π) = 2+ channel spin contribution has been determined model-independently and unambiguously for 22 primary transitions. The average Jsup(π) = 2+ channel contribution is 5.8%. Spins of final levels are in agreement with previous assignments. For three levels spin restrictions have been made. The energies of positive parity levels are in agreement with a shell model calculation in the complete sd shell. Finally, the nuclear level densities of the 24Na, 46Sc, 484950Ti, 60Co, 6465Cu and 239U nuclei recently investigated by means of thermal neutron capture are described with the Fermi gas theory. Experimentally observed pairing effects in the level density parameter for nuclei in the mass region A = 40-81 are explained theoretically. (Auth.)

  16. Parallelization of kinetic Monte Carlo algorithm to simulate AL3Sc precipitation

    OpenAIRE

    Moura, Alfredo de; Esteves, António

    2015-01-01

    The present paper reports the precipitation process of Al3Sc structures in an aluminum scandium alloy, which has been simulated with a synchronous parallel kinetic Monte Carlo (spkMC) algorithm. The spkMC implementation is based on the vacancy diffusion mechanism. To filter the raw data generated by the spkMC simulations, the density-based clustering with noise (DBSCAN) method has been employed. spkMC and DBSCAN algorithms were implemented in the C language and using MPI library. The simulati...

  17. Molecular dynamics study of ion capture from water by a model ionophore, tetraprotonated cryptand SC24

    Science.gov (United States)

    Owenson, Brian; Macelroy, Robert D.; Pohorille, Andrew

    1988-01-01

    The molecular dynamics of chloride capture from water by the tetraprotonated cryptand SC24 has been studied for the cases of 19 distances between the criptand and the chloride. The chloride capture is found to be characterized by a rapid cooperative change in the conformation of the cryptand when the Cl(-) begins to enter the ligand and just as it encounters the energy barrier. The conformational transition is associated with a shift of three N-H bonds from the pure endo orientation, such that they point toward the chloride.

  18. Cluster iron lines and the X-ray spectrum of SC 0627 - 544

    International Nuclear Information System (INIS)

    Further observations with the MSSL proportional counter spectrometer on the Ariel V satellite have led to the detection (at a confidence level of at least 99 per cent) of a highly ionized iron emission feature in the spectrum of the southern cluster SC 0627 - 544. The data obtained are compared with previous observations of this source made by the Goddard Space Flight Center's instrument on OSO-8. Iron emission feature detections with greater than 99 per cent confidence levels have now been made for five clusters of galaxies. A value of cluster iron abundance is deduced from these data. (author)

  19. Electronic structure of new mixed Ti13MC13 nanocrystallites (M = Sc, V, ..., Cu)

    International Nuclear Information System (INIS)

    The electron structure of the series of new Ti13MC13 metal-carbon molecular nanocrystallites is studied through the ab initio self-consistent discrete variation method. The third order metals (Sc, V, ..., Cu) are considered as the M-elements. The regularities of forming the electron structure, chemical bonds, charge distributions and atomic magnetic moments in the Ti13MC13 in dependence on the M-atom type and its position in the source Ti14C13 nanocrystallite are forecasted. The obtained results are compared with the electron states calculations of the 3d-admixtures in the crystalline titanium carbide

  20. The NASA/IPAC/NExScI Star and Exoplanet Database

    OpenAIRE

    Berriman, G. B.; Ali, B.; Baker, R; von Braun, K.; Chiu, N-M.; Ciardi, D. R.; Good, J.; Kane, S.R.; Kong, M.; Laity, A. C.; McElroy, D. L.; Monkewitz, S.; Payne, A N; Ramirez, S.; Schmitz, M.

    2009-01-01

    The NASA/IPAC/NExScI Star and Exoplanet Database (NStED) is a general purpose stellar archive which supports NASA planet-finding and planet-characterization goals, stellar astrophysics, and the planning of NASA and other space missions. There are two principal components of NStED: a database of 140,000 nearby stars and exoplanet-hosting stars, and an archive dedicated to high precision photometric surveys for transiting exoplanets (NStED-ETSS). We present summaries of these components. The NS...

  1. In vitro deletions in the partition locus of plasmid pSC101.

    OpenAIRE

    Kalla, S R; Gustafsson, P

    1984-01-01

    Deletion mutants in the 375-base-pair EcoRI-AvaI fragment carrying the partition locus of plasmid pSC101 were formed by the combined action of exonuclease III and nuclease S1. Six deletion mutants were isolated, and the endpoints of the deletions were sequenced. One of the deletions extended 69 base pairs from the EcoRI site without impairing plasmid stability. The other five deletions caused the plasmid to be unstable and extended 199 to 251 base pairs from the EcoRI site.

  2. Conversion of the dual training aircraft (DC into single control advanced training aircraft (SC. Part I

    Directory of Open Access Journals (Sweden)

    Ioan ŞTEFĂNESCU

    2011-03-01

    Full Text Available Converting the DC school jet aircraft into SC advanced training aircraft - and use them forthe combat training of military pilots from the operational units, has become a necessity due to thebudget cuts for Air Force, with direct implications on reducing the number of hours of flight assignedto operating personnel for preparing and training.The purpose of adopting such a program is to reduce the number of flight hours allocated annuallyfor preparing and training in advanced stages of instruction, for every pilot, by more intensive use ofthis type of aircraft, which has the advantage of lower flight hour costs as compared to a supersoniccombat plane.

  3. Scénarisation des enseignements dans le campus numérique PEGASUS

    OpenAIRE

    Auvergne, Jean-François

    2003-01-01

    PEGASUS, campus numérique regroupant 6 universités françaises, est une préparation « tout-en-ligne » au Diplôme d'Accès aux Etudes Universitaires (DAEU). Cettecommunication expose les principes, les étapes, les modalités, les principaux problèmes rencontrés ainsi que les solutions apportées lors du travail avec les enseignants-auteurs pour la scénarisation des contenus en-ligne.

  4. Growth and scintillation properties of Sc, Pr, Ce co-doped LuAG epitaxial layers

    Czech Academy of Sciences Publication Activity Database

    Kučera, M.; Průša, Petr; Mareš, Jiří A.; Nikl, Martin; Nitsch, Karel; Hanuš, M.; Onderišinová, Z.; Kučerková, Romana

    Bristol : IOP Publishing, 2010, 012012/1-012012/9. ISSN 1757-8981. - (IOP Conference Series: Materials Science and Engineering. vol. 15). [Europhysical Conference on Defects in Insulating Materials /11./ (EURODIM 2010). Pecs (HU), 12.07.2010-16.07.2010] R&D Projects: GA AV ČR KAN300100802 Institutional research plan: CEZ:AV0Z10100521 Keywords : scintillation * epitaxial layers * Sc * Pr * Ce dopants * LuAG garnet Subject RIV: BM - Solid Matter Physics ; Magnetism http://dx.doi.org/10.1088/1757-899X/15/1/012012

  5. ESR evidence of octahedral site occupation in ScH/sub x/:Er

    International Nuclear Information System (INIS)

    The Er3+ electron spin resonance spectrum at low temperatures in powdered Sc 9988Er 0012H191 contains a GAMMA7 doublet and associated hyperfine components with cubic site symmetry plus four additinal resonances arising from two distinct transitions with axial site symmetry. The axial lines are attributed to octahedral site occupation by protons in the vicinity of some Er3+ impurities. The two axial transitions may be associated with two different types of distortions of the GAMMA7 wave functions or possibly a GAMMA81 quartet state

  6. Flashlamp pumped lasing performance of Cr/sup 3+/:GdScGa-Garnet

    International Nuclear Information System (INIS)

    Chromium doped GdScGa-Garnet (Cr:GSGG) exhibits broadband fluorescence in the 700-900 nm region. Growth of this material and lasing at 790 nm with laser pumping was previously reported. Another work subsequently reported flashlamp pumped lasing of a 3.9 mm by 40 m Cr:GSGG rod. In this paper, the authors report on lasing performance of a flashlamp pumped Cr:GSGG laser rod and its lasting threshold for different operating temperatures. Evidence is presented that points to excited state absorption as a limiting factor in this material's performance

  7. Electron paramagnetic resonance of Cr3+ ions in ABO3 (A = Sc, Lu, In) diamagnetic crystals

    Science.gov (United States)

    Vorotynov, A. M.; Ovchinnikov, S. G.; Rudenko, V. V.; Vorotynova, O. V.

    2016-04-01

    A magnetic resonance method is applied to the investigation of a number of isostructural diamagnetic compounds ABO3 (A = Sc, Lu, In) with small additions of Cr3+ ions ( S = 3/2) sufficient to observe single-ion spectra. It is shown that the resonance spectra for isolated Cr3+ ions can be described to a good accuracy by the ordinary axial spin Hamiltonian for 3 d ions in octahedral oxygen environment. The parameters of the spin Hamiltonian are determined. It is established that Cr3+ ions in these crystals are characterized by easy-axis-type anisotropy.

  8. Topological band order, structural, electronic and optical properties of XPdBi (X = Lu, Sc) compounds

    Science.gov (United States)

    Narimani, M.; Nourbakhsh, Z.

    2016-05-01

    In this paper, the structural, electronic and optical properties of LuPdBi and ScPdBi compounds are investigated using the density functional theory by WIEN2K package within the generalized gradient approximation, local density approximation, Engel-Vosco generalized gradient approximations and modified Becke-Johnson potential approaches. The topological phases and band orders of these compounds are studied. The effect of pressure on band inversion strength, electron density of states and the linear coefficient of the electronic specific heat of these compounds is investigated. Furthermore, the effect of pressure on real and imaginary parts of dielectric function, absorption and reflectivity coefficients of these compounds is studied.

  9. Pesquisa de clima organizacional em empresas de desenvolvimento de software de Blumenau – SC

    OpenAIRE

    Aléssio, Simone Cristina; Dalfovo, Oscar; Dalfovo, Michael Samir; Fialho, Francisco Antonio Pereira

    2009-01-01

    O objetivo deste trabalho é estudar a influência das variáveis que compõem o Clima Organizacional em ambientes de desenvolvimento de software do município de Blumenau, SC, com o propósito de analisar as relações existentes nestes ambientes de trabalho. Parte-se do pressuposto de que as pessoas são as figuras mais importantes em uma organização, e o modo como se sente é fundamental para o equilíbrio de todos. Por isso, enfoca-se bastante a questão da cultura organizacional, que influencia dire...

  10. Pesquisa de clima organizacional em empresas de desenvolvimento de software de Blumenau – SC

    OpenAIRE

    Simone Cristina Aléssio; Oscar Dalfovo; Michael Samir Dalfovo; Francisco Antonio Pereira Fialho

    2010-01-01

    O objetivo deste trabalho é estudar a influência das variáveis que compõem o Clima Organizacional em ambientes de desenvolvimento de software do município de Blumenau, SC, com o propósito de analisar as relações existentes nestes ambientes de trabalho. Parte-se do pressuposto de que as pessoas são as figuras mais importantes em uma organização, e o modo como se sente é fundamental para o equilíbrio de to...

  11. Biogas Upgrading Using SOEC with a Ni-ScYSZ Electrode

    DEFF Research Database (Denmark)

    Ebbesen, Sune Dalgaard; Bøgild Hansen, John; Mogensen, Mogens Bjerg

    2013-01-01

    Biogas consists mainly of CH4, CO2 and small amounts of H2S. The value of biogas will increase significantly if it is upgraded to pipeline quality by converting CO2 and H2O in the biogas to CO and H2 using a Solid Oxide Electrolysis Cell (SOEC) followed by methanation. The Ni-ScYSZ-cermet electrode...... is, however, active for steam reforming of CH4, but sulphur traces in the biogas reduce the steam reforming activity. It is proven that sulphur stops steam reforming activity whereas the electrochemistry is only affected to a limited degree, showing that up-grading of biogas using SOEC with Ni...

  12. A humanized anti-M2 scFv shows protective in vitro activity against influenza

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M [Los Alamos National Laboratory; Velappan, Nileena [Los Alamos National Laboratory; Schmidt, Jurgen G [Los Alamos National Laboratory

    2008-01-01

    M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.

  13. The crystal structure of Sc{sub 5}Co{sub 2}In{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Tyvanchuk, Yuriy; Gulay, Nataliya; Bigun, Inna; Kalychak, Yaroslav [Ivan Franko National University of Lviv (Ukraine). Analytical Chemistry Dept.; Galadzhun, Yaroslav [Ivan Franko National University of Lviv (Ukraine). Dept. of Life Safety

    2015-07-01

    The new intermetallic compound Sc{sub 5}Co{sub 2}In{sub 4} was synthesized by arc melting of the pure metals. Its crystal structure was investigated from single-crystal X-ray data: Pbam, a = 17.3400(7), b = 7.5940(5), c = 3.3128(2) Aa, R1 = 0.0337, wR2 = 0.0620 for 1502 independent reflections with [I > 2 σ(I)]. It is the first representative of the Lu{sub 5}Ni{sub 2}In{sub 4} type with cobalt.

  14. Outline and schedule for the HTGR-SC/C licensing plan

    International Nuclear Information System (INIS)

    The Licensing Plan is based on licensing a HTGR-SC/C lead plant in the near term. The plan also provides reference safety material and a basis (requirements, criteria, etc.) for licensing commercial follow-on plants. The plan is structured in two parts: program management and project management, and covers three sequences of licensing activities: pre-application, construction permit application, and operating licensing application. Major activities and a schedule of events are outlined in these three phases indicating the approach, the objective and the documentation involved. The Licensing Plan will be further developed in detail in FY 1982 as part of a Project Decision Package

  15. Optical and Electronic Properties of Double Perovskite Ba2ScSbO6

    OpenAIRE

    Ray, Rajyavardhan; Himanshu, A. K.; Kumar, Uday; Sen, Pintu; Lahiri, J.; Bandyopadhyay, S K; Sinha, T. P.

    2015-01-01

    Ba2ScSbO6 (BSS) has been synthesized in polycrystalline form by solid state reaction. Structural characterization of the compound was done through X-ray diffraction (XRD) followed by Riedvelt analysis of the XRD pattern. The crystal structure is cubic, space group Fm-3m (No. 225. Optical band-gap of the present system has been calculated using the UV-Vis Spectroscopy to be 4.2eV. A detailed study of the electronic properties has also been carried out using the Full-Potential Linear Augmented ...

  16. Probiotic Bacillus amyloliquefaciens SC06 Prevents Bacterial Translocation in Weaned Mice

    OpenAIRE

    Ji, Jian; Hu, Shenglan; Li, Weifen

    2013-01-01

    Probiotic is a preparation containing microorganisms that confers beneficial effect to the host. This work assessed whether oral administration of Bacillus amyloliquefaciens SC06 (Ba) could decrease bacterial translocation in weaned mice. Weaned C57BL/6 were randomly allocated into three groups: group I as the control group, group II were treated with 0.85 % NaCl. Group III was administered with probiotic Ba 1 × 109 CFU/day dissolved in 100 μl of 0.85 % NaCl for 30 days. Mice were then sacrif...

  17. Electronic, structural, and elastic properties of metal nitrides XN (X = Sc, Y): A first principle study

    OpenAIRE

    Ekuma, Chinedu E.; Diola Bagayoko; Mark Jarrell; Juana Moreno

    2012-01-01

    We utilized a simple, robust, first principle method, based on basis set optimization with the BZW-EF method, to study the electronic and related properties of transition metal mono-nitrides: ScN and YN. We solved the KS system of equations self-consistently within the linear combination of atomic orbitals (LCAO) formalism. It is shown that the band gap and low energy conduction bands, as well as elastic and structural properties, can be calculated with a reasonable accuracy when the LCAO for...

  18. Gamow-Teller Transitions Starting from Tz = +3/2 Nucleus 45Sc

    International Nuclear Information System (INIS)

    Owing to its simplicity and also its nature of spin-isospin (στ) excitation, Gamow-Teller (GT) transitions play key roles in the studies of nuclear structure as well as astro-nuclear processes. We studied GT transitions starting from 45Sc in a high-resolution (3He,t) charge-exchange reactions at 0 deg. and at an intermediate incoming energy of 140 MeV/nucleon. Individual GT transitions were observed up to high excitation energy of 10 MeV and a concentration of GT strength, a resonance-like structure, was observed at 6.5 MeV.

  19. Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction

    Science.gov (United States)

    Fehl, Charlie; Hirt, Erin E.; Li, Sze-Wan; Aubé, Jeffrey

    2015-01-01

    The intramolecular Schmidt reaction of ketones and tethered azides is an efficient method for the generation of amides and lactams. This reaction is catalyzed by Lewis acids, which tightly bind the strongly basic amide product and result in product inhibition. We report herein conditions to achieve a catalytic Schmidt reaction using substoichiometric amounts of the heat-stable Lewis acid Sc(OTf)3. This species was shown to effectively release products of the Schmidt reaction in a temperature-dependent fashion. Thus, heat was able to promote catalyst turnover. A brief substrate scope was conducted using these conditions. PMID:26085693

  20. Supercritical carbon dioxide (SC-CO2) as a clean technology for palm kernel oil extraction

    OpenAIRE

    Norhuda I; Jusoff K

    2009-01-01

    Efforts towards application of Supercritical Carbon Dioxide (SCCO2) extraction in Malaysia are still at its infancy stage. More research has actively on-going to explore its potential performance on a bigger scale (industrial scale) so that it will provide a better alternative method of extraction compare to the present practice using organic solvent extraction. SC-CO2 has been proven on laboratory and pilot-scale as an effective extraction technique for large types of bio-materials such as h...

  1. A distorted tetrahedral metal oxide cluster inside an icosahedral carbon cage. Synthesis, isolation, and structural characterization of Sc4(mu3-O)2@Ih-C80.

    Science.gov (United States)

    Stevenson, Steven; Mackey, Mary A; Stuart, Melissa A; Phillips, J Paige; Easterling, Michael L; Chancellor, Christopher J; Olmstead, Marilyn M; Balch, Alan L

    2008-09-10

    The remarkably large cluster Sc4(mu3-O)2 has been obtained trapped inside an Ih-C80 cage by conducting the vaporization of graphite rods doped with copper(II) nitrate and scandium(III) oxide in an electric arc under a low pressure helium atmosphere with an added flow of air. The product has been isolated by chromatography and identified by high-resolution mass spectrometry. The structure of Sc4(mu3-O)2@Ih-C80 has been determined by X-ray crystallography on a crystal of Sc4(mu3-O)2@Ih-C80.NiII(OEP).2(C6H6). The Sc4(mu3-O)2 unit consists of a distorted tetrahedron of scandium atoms with oxygen atoms bridging two of its faces. The Sc-Sc distances range from 2.946(7) to 3.379(7) A. PMID:18702488

  2. Zero lattice mismatch and twin-free single crystalline ScN buffer layers for GaN growth on silicon

    International Nuclear Information System (INIS)

    We report the growth of thin ScN layers deposited by plasma-assisted molecular beam epitaxy on Sc2O3/Y2O3/Si(111) substrates. Using x-ray diffraction, Raman spectroscopy, and transmission electron microscopy, we find that ScN films grown at 600 °C are single crystalline, twin-free with rock-salt crystal structure, and exhibit a direct optical band gap of 2.2 eV. A high degree of crystalline perfection and a very good lattice matching between ScN and GaN (misfit < 0.1%) makes the ScN/Sc2O3/Y2O3 buffer system a very promising template for the growth of high quality GaN layers on silicon

  3. Carbon Dioxide Activation by Scandium Atoms and Scandium Monoxide Molecules: Formation and Spectroscopic Characterization of ScCO3 and OCScCO3 in Solid Neon.

    Science.gov (United States)

    Zhang, Qingnan; Qu, Hui; Chen, Mohua; Zhou, Mingfei

    2016-01-28

    The reactions of carbon dioxide with scandium monoxide molecules and scandium atoms are investigated using matrix isolation infrared spectroscopy in solid neon. The species formed are identified by the effects of isotopic substitution on their infrared spectra as well as density functional calculations. The results show that the ground state ScO molecule reacts with carbon dioxide to form the carbonate complex ScCO3 spontaneously on annealing. The ground state Sc atom reacts with two carbon dioxide molecules to give the carbonate carbonyl complex OCScCO3 via the previously reported OScCO insertion intermediate on annealing. The observation of these spontaneous reactions is consistent with theoretical predictions that both the Sc + 2CO2 → OCScCO3 and ScO + CO2 → ScCO3 reactions are thermodynamically exothermic and are kinetically facile, requiring little or no activation energy. PMID:26738558

  4. Zero lattice mismatch and twin-free single crystalline ScN buffer layers for GaN growth on silicon

    Energy Technology Data Exchange (ETDEWEB)

    Lupina, L.; Zoellner, M. H.; Dietrich, B.; Capellini, G. [IHP, Im Technologiepark 25, 15236 Frankfurt, Oder (Germany); Niermann, T.; Lehmann, M. [Technische Universität Berlin, Institut für Optik und Atomare Physik, Straße des 17. Juni 135, 10623 Berlin (Germany); Thapa, S. B.; Haeberlen, M.; Storck, P. [SILTRONIC AG, Hanns-Seidel-Platz 4, 81737 München (Germany); Schroeder, T. [IHP, Im Technologiepark 25, 15236 Frankfurt, Oder (Germany); BTU Cottbus, Konrad-Zuse-Str. 1, 03046 Cottbus (Germany)

    2015-11-16

    We report the growth of thin ScN layers deposited by plasma-assisted molecular beam epitaxy on Sc{sub 2}O{sub 3}/Y{sub 2}O{sub 3}/Si(111) substrates. Using x-ray diffraction, Raman spectroscopy, and transmission electron microscopy, we find that ScN films grown at 600 °C are single crystalline, twin-free with rock-salt crystal structure, and exhibit a direct optical band gap of 2.2 eV. A high degree of crystalline perfection and a very good lattice matching between ScN and GaN (misfit < 0.1%) makes the ScN/Sc{sub 2}O{sub 3}/Y{sub 2}O{sub 3} buffer system a very promising template for the growth of high quality GaN layers on silicon.

  5. 78 FR 42999 - City of Pickens, S.C. and City of Easley, S.C.-Acquisition Exemption-Pickens Railway Company

    Science.gov (United States)

    2013-07-18

    ... Surface Transportation Board City of Pickens, S.C. and City of Easley, S.C.--Acquisition Exemption--Pickens Railway Company The City of Pickens, S.C., and the City of Easley, S.C. (collectively, the Cities...) approximately 8.5 miles of railroad right-of-way between milepost 0.0, at or near Pickens, and milepost 8.5,...

  6. Effect of Sc{sub 2}O{sub 3} particles on the microstructure and properties of tungsten alloy prepared by spark plasma sintering

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hong-Yu [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); Luo, Lai-Ma, E-mail: luolaima@126.com [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China); Chen, Jing-Bo [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); Li, Ping [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China); Luo, Guang-Nan [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Cheng, Ji-Gui [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China); Wu, Yu-Cheng, E-mail: ycwu@hfut.edu.cn [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China)

    2015-07-15

    Highlights: • Effect of Sc{sub 2}O{sub 3} on microstructure and properties of tungsten alloy were studied. • Sc{sub 2}O{sub 3} significantly refined the grain size and increased the density of tungsten alloy. • The tensile strength values of the W–2 vol%Sc{sub 2}O{sub 3} samples were higher than the others. - Abstract: W–Sc{sub 2}O{sub 3} composite powders (W, W–0.5 vol%Sc{sub 2}O{sub 3}, and W–2 vol%Sc{sub 2}O{sub 3}) doped with highly uniform Sc{sub 2}O{sub 3} particles were successfully synthesized by mechanical alloying followed by hydrogen reduction with Sc{sub 2}O{sub 3} and WO{sub 3} powders. The reduced powders were then consolidated by spark plasma sintering at 1700 °C to suppress grain growth during sintering. Field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and high-resolution transmission electron microscopy analyses, as well as tensile tests and thermal conductivity measurements, were used to characterize the samples. The results showed that the Sc{sub 2}O{sub 3} particles were uniformly distributed in the tungsten grains and grain boundaries. The W–2vol%Sc{sub 2}O{sub 3} composite possess the best relative density and Vickers micro-hardness up to 98.6% and 683.2 Hv, respectively. The Sc{sub 2}O{sub 3} particles significantly refine the grain size and increase the density of tungsten alloy. With increased Sc{sub 2}O{sub 3} content, the thermal conductivity decreased while tensile strength of the samples respectively increased at 700 and 800 °C.

  7. Use of Antifungal Saponin SC-2 of Solanum Chrysotrichum for the Treatment of Vulvovaginal Candidiasis: In Vitro Studies and Clinical Experiences

    OpenAIRE

    Herrera-Arellano, Armando; López-Villegas, Edgar O; Rodríguez-Tovar, Aida V; Zamilpa, Alejandro; Jiménez-Ferrer, Enrique; Tortoriello, Jaime; Martínez-Rivera, M Angeles

    2013-01-01

    Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinic...

  8. Intramuscular scAAV9-SMN Injection Mediates Widespread Gene Delivery to the Spinal Cord and Decreases Disease Severity in SMA Mice

    OpenAIRE

    Benkhelifa-Ziyyat, Sofia; Besse, Aurore; Roda, Marianne; Duque, Sandra; Astord, Stéphanie; Carcenac, Romain; Marais, Thibaut; Barkats, Martine

    2013-01-01

    We have recently demonstrated the remarkable efficiency of self-complementary (sc) AAV9 vectors for central nervous system (CNS) gene transfer following intravenous delivery in mice and larger animals. Here, we investigated whether gene delivery to motor neurons (MNs) could also be achieved via intramuscular (i.m.) scAAV9 injection and subsequent retrograde transport along the MNs axons. Unexpectedly, we found that a single injection of scAAV9 into the adult mouse gastrocnemius (GA) mediated ...

  9. K2SC: Flexible systematics correction and detrending of K2 light curves using Gaussian Process regression

    CERN Document Server

    Aigrain, Suzanne; Pope, Benjamin

    2016-01-01

    We present K2SC (K2 Systematics Correction), a Python pipeline to model instrumental systematics and astrophysical variability in light curves from the K2 mission. K2SC uses Gaussian process regression to model position-dependent systematics and time-dependent variability simultaneously, enabling the user to remove both (e.g., for transit searches) or to remove systematics while preserving variability (for variability studies). For periodic variables, K2SC automatically computes estimates of the period, amplitude and evolution timescale of the variability. We apply K2SC to publicly available K2 data from campaigns 3--5, showing that we obtain photometric precision approaching that of the original Kepler mission. We compare our results to other publicly available K2 pipelines, showing that we obtain similar or better results, on average. We use transit injection and recovery tests to evaluate the impact of K2SC on planetary transit searches in K2 PDC (Pre-search Data Conditioning) data, for planet-to-star radi...

  10. The pyrochlore-type molybdate Pr2Mo1.73Sc0.27O7

    Directory of Open Access Journals (Sweden)

    Philippe Gall

    2012-12-01

    Full Text Available Dipraseodymium molybdenum scandium heptaoxide, Pr2Mo1.73Sc0.27O7, crystallizes in the cubic pyrochlore-type structure. In the crystal, (Mo,ScO6 octahedra are linked together by common corners, forming a three-dimensional [(Mo,Sc2O6] framework. The Pr atom and another O atom atom are located in the voids of this framework. The Mo and the Sc atom are distributed statistically over the same 16d crystallographic position, with site-occupancy factors of 0.867 (3 and 0.133 (3, respectively. The Pr3+ ions are surrounded by six O atoms from the MoO6 octahedra and by two other O atoms, forming a ditrigonal scalenohedron. All atoms lie on special positions. The Pr and the statistically distributed (Mo,Sc sites are in the 16c and 16d positions with .-3m symmetry, and two O atoms are in 48f and 8a positions with 2.mm and -43m site symmetry, respectively.

  11. Process boundaries of irreversible scCO2 -assisted phase separation in biphasic whole-cell biocatalysis.

    Science.gov (United States)

    Brandenbusch, Christoph; Glonke, Sebastian; Collins, Jonathan; Hoffrogge, Raimund; Grunwald, Klaudia; Bühler, Bruno; Schmid, Andreas; Sadowski, Gabriele

    2015-11-01

    The formation of stable emulsions in biphasic biotransformations catalyzed by microbial cells turned out to be a major hurdle for industrial implementation. Recently, a cost-effective and efficient downstream processing approach, using supercritical carbon dioxide (scCO2 ) for both irreversible emulsion destabilization (enabling complete phase separation within minutes of emulsion treatment) and product purification via extraction has been proposed by Brandenbusch et al. (2010). One of the key factors for a further development and scale-up of the approach is the understanding of the mechanism underlying scCO2 -assisted phase separation. A systematic approach was applied within this work to investigate the various factors influencing phase separation during scCO2 treatment (that is pressure, exposure of the cells to CO2 , and changes of cell surface properties). It was shown that cell toxification and cell disrupture are not responsible for emulsion destabilization. Proteins from the aqueous phase partially adsorb to cells present at the aqueous-organic interface, causing hydrophobic cell surface characteristics, and thus contribute to emulsion stabilization. By investigating the change in cell-surface hydrophobicity of these cells during CO2 treatment, it was found that a combination of catastrophic phase inversion and desorption of proteins from the cell surface is responsible for irreversible scCO2 mediated phase separation. These findings are essential for the definition of process windows for scCO2 -assisted phase separation in biphasic whole-cell biocatalysis. PMID:26012371

  12. Crystal structure of the Sc{sub 2}PbX{sub 4} (X = S and Se) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Shemet, V.Ya. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave. 13, 43009 Lutsk (Ukraine); Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave. 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@lab.univ.lutsk.ua; Stepien-Damm, J. [W. Trzebiatowski Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wroclaw (Poland); Pietraszko, A. [W. Trzebiatowski Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wroclaw (Poland); Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave. 13, 43009 Lutsk (Ukraine)

    2006-01-05

    The crystal structure of the Sc{sub 2}PbX{sub 4} (X = S and Se) compounds (space group Pnma, Pearson symbol oP28) were determined by means of X-ray single crystal diffraction (a = 1.1642(4) nm, b = 0.3757(1) nm, c = 1.3711(4) nm, R {sub 1} = 0.0420 (Sc{sub 2}PbS{sub 4})) and X-ray powder diffraction (a = 1.22029(5) nm, b 0.39061(2) nm, c = 1.42801(6) nm, R {sub Bragg} = 0.0954 (Sc{sub 2}PbSe{sub 4})). Both compounds crystallize in the CaFe{sub 2}O{sub 4} structure type. The Sc-centered octahedra and Pb-centered trigonal prisms with two additional atoms form columns along the Y-axis in the structure of the Sc{sub 2}PbX{sub 4} (X = S and Se) compounds.

  13. Comparative study of Tm-doped and Tm-Sc co-doped Lu3Al5O12 scintillator

    International Nuclear Information System (INIS)

    The crystals of Tm doped and Tm-Sc co-doped Lu3Al5O12 (LuAG) grown by the floating zone (FZ) method were examined for their optical and scintillation properties. In transmittance spectra, strong absorption lines due to Tm3+ 4f–4f transitions were observed. X-ray excited radioluminescence spectra were measured and broad and sharp emission peaks were detected. The former one was attributed to Sc3+ and the latter one was due to Tm3+ 4f–4f transitions. Scintillation yield enhancement due to Sc co-doping was observed by means of 137Cs pulse height spectra. Scintillation decay times were several tens of μs under pulse X-ray excitation. - Highlights: • LuAG:Tm and LuAG:Tm, Sc single crystals have been grown by the FZ method. • Tm3+ 4f–4f absorption has been observed in transmittance spectra. • Scintillation yield of Tm-doped LuAG has been enhanced by Sc co-doping

  14. A DFT study of the effects of Sc doping on electronic and optical properties of CdS nanoparticles

    Directory of Open Access Journals (Sweden)

    Ur Rehman Shafiq

    2015-12-01

    Full Text Available In the present work a systematic study was carried out to understand the influence of Sc doping on electronic and optical properties of CdS nanoparticles. The geometry optimization and symmetry computation for CdS and Sc doped CdS nanoparticles using Density Functional Theory (DFT on B3LYP level with the QZ4P for Cd and DZ2P for sulphur and Sc were performed by Amsterdam Density Functional (ADF. The results show that HOMO-LUMO gap as well as electronic and optical properties of CdS clusters vary with Sc doping. The HOMO-LUMO gap is affected by the dopant and its value decreases to 0.6 eV. Through considering the numerical integration scheme in the ADF package, we investigated different vibrational modes and our calculated Raman and IR spectra are consistent with the reported result. The calculated IR and Raman peaks of CdS and Sc doped CdS clusters were in the range of 100 to 289 cm−1, 60 cm−1 to 350 cm−1 and 99 cm−1 to 282 cm−1, 60 cm−1 to 350 cm−1, respectively, which was also confirmed by experiment as well as a blue shift occurrence. Subsequently, for deeper research of pure and doped CdS clusters, their absorption spectra were calculated using time-dependent DFT method.

  15. Selection of scFvs specific for the HepG2 cell line using ribosome display

    Indian Academy of Sciences (India)

    Lei Zhou; Wei-Ping Mao; Juan Fen; Hong-Yun Liu; Chuan-Jing Wei; Wen-Xiu Li; Feng-Yun Zhou

    2009-06-01

    The aim of this study was to construct a ribosome display library of single chain variable fragments (scFvs) associated with hepatocarcinoma and screen such a library for hepatocarcinoma-binding scFvs. mRNA was isolated from the spleens of mice immunized with hepatocellular carcinoma cell line HepG2. Heavy and k chain genes (VH and k) were amplified separately by RT-PCR, and an anti-HepG2 VH/k chain ribosome display library was constructed by assembling VH and k into the VH/k chain with a specially constructed linker by SOE-PCR. The VH/k chain library was transcribed and translated in vitro using a rabbit reticulocyte lysate system. In order to isolate specific scFvs, recognizing HepG2 negative selection on a normal hepatocyte line WRL-68 was carried out before three rounds of positive selection on HepG2. After three rounds of panning, cell enzyme-linked immunosorbent assay (ELISA) showed that one of the scFvs had high affinity for the HepG2 cell and lower affinity for the WRL-68 cell. In this study, we successfully constructed a native ribosome display library. Such a library would prove useful for direct intact cell panning using ribosome display technology. The selected scFv had a potential value for hepatocarcinoma treatment.

  16. scFv from Antibody That Mimics gp43 Modulates the Cellular and Humoral Immune Responses during Experimental Paracoccidioidomycosis.

    Directory of Open Access Journals (Sweden)

    Grasielle Pereira Jannuzzi

    Full Text Available Paracoccidioidomycosis (PCM, caused by Paracoccidioides species is a prevalent systemic and progressive mycosis that occurs in Latin America. It is caused by Paracoccidioides species. Immunization with dendritic cells transfected with a plasmid encoding the scFv (pMAC/PS-scFv that mimics the main antigen of P. brasiliensis (gp43 confers protection in experimental PCM. DCs link innate and adaptive immunity by recognizing invading pathogens and selecting the type of effector T cell to mediate the immune response. Here, we showed that DC-pMAC/PS-scFv induces the activation of CD4+ and CD8+ T cells. Moreover, our results demonstrated that BALB/c mice infected with P. brasiliensis and treated with DC-pMAC/PS-scFv showed the induction of specific IgG production against gp43 and IFN-γ, IL-12 and IL-4 cytokines. Analysis of regional lymph nodes revealed increases in the expression of clec7a, myd88, tlr2, gata3 and tbx21, which are involved in the immune response. Taken together, our results indicate that the scFv modulates the humoral and cellular immune responses and presents epitopes to CD4+ and CD8+ T cells.

  17. [Stable expression of human anti-IL-33 scFv-IgG1Fc fusion protein in CHO k1 cells].

    Science.gov (United States)

    Ye, Yingchun; Nian, Siji; Wang, Xu; Wu, Tong; Xu, Wenfeng; Yuan, Qing

    2016-05-01

    Objective To construct two different eukaryotic expression vectors of human anti-interleukin 33 (IL-33) single-chain antibody fragment (scFv-Fc) to transfect Chinese hamster ovary (CHO) k1 cells and select the stably and high-level expressed cell lines to improve the expression level of the fusion protein. Methods The previously constructed recombinant plasmid pcDNA3.1/SP-scFv-Fc was digested to obtain SP-scFv-Fc fragments, and the fragments were inserted into the plasmid PMH3(EN) to construct recombinant plasmid PMH3(EN)/SP-scFv-Fc. The plasmids PMH3(EN)/SP-scFv-Fc and pcDNA3.1/SP-scFv-Fc were separately transfected into CHO k1 cells. The transcription and translation level of the SP-scFv-Fc were detected by reverse transcription PCR (RT-PCR) and Western blotting, respectively. The stably and high-level expressed cell lines were screened by Dot blotting. The expression level and binding activity of the expressed scFv-Fc were measured by ELISA. Results The recombinant plasmid PMH3(EN)/SP-scFv-Fc was successfully constructed and the size of the inserted SP-scFv-Fc was about 1560 bp. The RT-PCR results showed that the SP-scFv-Fc was successfully transfected into CHO k1 cells. The scFv-Fc proteins could be secreted into the cultural supernatant and specifically bind to human IL-33 and anti human IgG1 Fc antibody. The expression level of scFv-Fc in plasmid PMH3(EN) was higher than that in plasmid pcDNA3.1. After four rounds of screening, the stably and high-level expressed cell strains were obtained. The expression level of the scFv-Fc was about 10 mg/L. The competitive ELISA results showed that the expressed scFv-Fc fusion proteins could inhibit the binding of IL-33 to ST2. Conclusion The anti-IL-33 scFv-Fc proteins were highly expressed in CHO k1 cells. PMID:27126936

  18. Radiation-induced frequency transients in AT, BT, and SC cut quartz resonators

    International Nuclear Information System (INIS)

    Earlier studies of transient frequency changes in high-purity swept AT quartz resonators led to the conclusion that impurity-induced effects were small, while the observed changes were qualitatively and quantitatively well characterized in terms of the time changing temperature of the vibrating quartz and its effect on frequency. 5 MHz, AT cut fifth overtone, and BT and SC cut third overtone resonators were prepared from a single stone of Sawyer swept Premium-Q quartz. The resonators were operated in precision ovenized oscillators at or near their turnover temperatures. Pulsed irradiation, at dose levels of the order of 104 rads (Si) per pulse, was accomplished at Sandia. The experimental data display negative frequency transients for the AT cut resonators, positive frequency transients for the BT cut resonators, and very small transient effects for the SC cut resonators. From these experimental results, it is concluded that no measurable impurity-induced frequency changes are observed in this high-purity swept-quartz and that the frequency transients are accurately modelled in terms of transient temperature effects stemming from the thermal characteristics of the resonator structure

  19. An alternative method for determination of oscillator strengths: The example of Sc II

    International Nuclear Information System (INIS)

    We describe our method for determining oscillator strengths and hyperfine structure splittings that is an alternative to the commonly used, purely theoretical calculations, or to the semi-empirical approach combined with theoretically calculated transition integrals. We have developed our own computer programs that allow us to determine all attributes of the structure of complex atoms starting from the measured frequencies emitted by the atoms. As an example, we present the results of the calculation of the structure, electric dipole transitions, and hyperfine splittings of Sc II. The angular coefficients of the transition matrix in pure SL coupling were found from straightforward Racah algebra. The transition matrix was transformed into the actual intermediate coupling by the fine structure eigenvectors obtained from the semi-empirical approach. The transition integrals were treated as free parameters in the least squares fit to experimental gf values. For most transitions, the experimental and the calculated gf-values are consistent with the accuracy claimed in the NIST compilation. - Highlights: • The method of simultaneous determination of all the attributes of atomic structure. • The semi-empirical method of parameterization of oscillator strengths. • Illustration of the method application for the example of Sc II data

  20. The ASCI Network for SC 2000: Gigabyte Per Second Networking; TOPICAL

    International Nuclear Information System (INIS)

    This document highlights the Discom's Distance computing and communication team activities at the 2000 Supercomputing conference in Dallas Texas. This conference is sponsored by the IEEE and ACM. Sandia's participation in the conference has now spanned a decade, for the last five years Sandia National Laboratories, Los Alamos National Lab and Lawrence Livermore National Lab have come together at the conference under the DOE's ASCI, Accelerated Strategic Computing Initiatives, Program rubric to demonstrate ASCI's emerging capabilities in computational science and our combined expertise in high performance computer science and communication networking developments within the program. At SC 2000, DISCOM demonstrated an infrastructure. DISCOM2 uses this forum to demonstrate and focus communication and pre-standard implementation of 10 Gigabit Ethernet, the first gigabyte per second data IP network transfer application, and VPN technology that enabled a remote Distributed Resource Management tools demonstration. Additionally a national OC48 POS network was constructed to support applications running between the show floor and home facilities. This network created the opportunity to test PSE's Parallel File Transfer Protocol (PFTP) across a network that had similar speed and distances as the then proposed DISCOM WAN. The SCINET SC2000 showcased wireless networking and the networking team had the opportunity to explore this emerging technology while on the booth. This paper documents those accomplishments, discusses the details of their convention exhibit floor. We also supported the production networking needs of the implementation, and describes how these demonstrations supports DISCOM overall strategies in high performance computing networking

  1. User's manuals of probabilistic fracture mechanics codes. PASCAL-SC and PASCAL-EQ

    International Nuclear Information System (INIS)

    As a part of the aging and structural integrity research for LWR components, new PFM (Probabilistic Fracture Mechanics) codes PASCAL-SC (PFM Analysis of Structural Components in Aging LWR - Stress Corrosion Cracking) and PASCAL-EQ (PFM Analysis of Structural Components in Aging LWR - EarthQuake) have been developed. These codes evaluate the failure probability of an aged welded joint by Monte Carlo method. PASCAL-SC treats Stress Corrosion Cracking (SCC) in piping, while PASCAL-EQ takes fatigue crack growth by seismic load into account. The development of these codes has been aimed to improve the accuracy and reliability of analysis by introducing new analysis and methodologies and algorithms the recent development in the fracture mechanics methodologies and computer performance. The crack growth by an irregular stress due to seismic load in detail is considered in these codes. They also involves recent stress intensity factors and fracture criteria. In addition, a user's friendly operations of a GUI (Graphical User Interface) which generates input data, supports calculations and plots results is introduced. This report provides the user's manual and theoretical background of these codes. (author)

  2. The elemental composition of the Sun II. The iron group elements Sc to Ni

    CERN Document Server

    Scott, Pat; Grevesse, Nicolas; Bergemann, Maria; Sauval, A Jacques

    2014-01-01

    We redetermine the abundances of all iron group nuclei in the Sun, based on neutral and singly-ionised lines of Sc, Ti, V, Mn, Fe, Co and Ni in the solar spectrum. We employ a realistic 3D hydrodynamic model solar atmosphere, corrections for departures from local thermodynamic equilibrium (NLTE), stringent line selection procedures and high quality observational data. We have scoured the literature for the best quality oscillator strengths, hyperfine constants and isotopic separations available for our chosen lines. We find $\\log \\epsilon_\\mathrm{Sc}=3.16\\pm0.04$, $\\log \\epsilon_\\mathrm{Ti}=4.90\\pm0.04$, $\\log \\epsilon_\\mathrm{V}=3.89\\pm0.08$, $\\log \\epsilon_\\mathrm{Cr}=5.62\\pm0.04$, $\\log \\epsilon_\\mathrm{Mn}=5.42\\pm0.04$, $\\log \\epsilon_\\mathrm{Fe}=7.47\\pm0.04$, $\\log \\epsilon_\\mathrm{Co}=4.93\\pm0.05$ and $\\log \\epsilon_\\mathrm{Ni}=6.20\\pm0.04$. Our uncertainties factor in both statistical and systematic errors (the latter estimated for possible errors in the model atmospheres and NLTE line formation). The ...

  3. Scientific issues and status of Franco-Italian collaboration on the sc linear accelerator for ads

    International Nuclear Information System (INIS)

    In the past few years national R and D programmes have started in France and Italy in the framework of accelerator-driven transmutation system (ADS). Limiting the discussion to the high current proton accelerator required to drive the spallation process, the two reference programmes are respectively ASH and TRASCO. Following the guidelines set by the representatives of the three national institutions involved, CEA, IN2P3 and INFN, we have recently converged to a common reference design for the high-energy part (above 85 MeV) of the superconducting (SC) linac. This paper will present a brief history and status of the two programmes, focusing the discussion on the common design and on the two co-ordinate R and D programmes foreseen in the next few years. The design and construction of two complete cryo-modules, each containing two SC cavities, is the major goal of this programme, together with the further development of the components for the low energy part of the accelerator, where alternative options are still open. (author)

  4. Feasibility of liquid hydrocarbon fuels for SOFC with Ni-ScSZ anode

    Energy Technology Data Exchange (ETDEWEB)

    Kishimoto, Haruo; Yamaji, Katsuhiko; Horita, Teruhisa; Xiong, Yueping; Sakai, Natsuko; Brito, Manuel E.; Yokokawa, Harumi [National Institute of Advanced Industrial Science and Technology (AIST), AIST Tsukuba Central No. 5, Higashi 1-1-1, Tsukuba, Ibaraki 305-8565 (Japan)

    2007-10-11

    Solid oxide fuel cell (SOFC) operation with a nickel-scandia stabilized zirconia (Ni-ScSZ) cermet anode was carried out with liquid hydrocarbon of n-dodecane (C{sub 12}H{sub 26}), used as a model fuel of kerosene, without fuel dilution by inert carrier gas. Continuous operation was achieved for more than 120 h at S/C = 2.0 and at 800 C. The obtained open circuit voltage was about -0.97 V and the average current density was about 140 mA cm{sup -2} under the constant anode potential of -0.75 V versus air. This current density corresponded to fuel utilization of 55%. In the impedance spectra for the anode, two semicircles were observed not only for hydrogen but also for C1 to C12 paraffin. Electrode conductivity for each semicircle, {sigma}{sub H} for high frequency part and {sigma}{sub L} for low frequency part, were calculated by following equation:{sigma}(S cm{sup -2})=1/ARwhere A (cm{sup 2}) is electrode area and R ({omega}) is electrode resistance determined from each semicircle. Electrode conductivities for hydrocarbon fuels showed the same water partial pressure dependence as that for hydrogen whether fuel is diluted or not. Hydrogen produced by reforming reaction was the most active element for electrochemical oxidation at the anode even for hydrocarbon fuels. (author)

  5. Characterization of semi-solid processing of aluminium alloy 7075 with Sc and Zr additions

    Energy Technology Data Exchange (ETDEWEB)

    Rogal, Ł., E-mail: l.rogal@imim.pl [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Dutkiewicz, J. [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Atkinson, H.V. [The University of Leicester, Department of Engineering University Road, Leicester, LE1 7RH (United Kingdom); Lityńska-Dobrzyńska, L.; Czeppe, T. [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Modigell, M. [RWTH Aachen—Department of Mechanical Process Engineering, 55 Templergraben St., Aachen (Germany)

    2013-09-15

    For thixoforming (semi-solid processing) it is necessary to have a fine globular microstructure in a semi-solid range. Here this has been obtained for 7075 aluminium alloy by addition of modifying agents: 0.5 weight % of scandium and zirconium. The thixoforming process was carried out at 632 °C which gave about 23 volume % of liquid phase. The microstructure of the thixo-formed part (a rotor) consisted of globular grains surrounded by precipitates of secondary phase. The average hardness of thixo-formed parts was 105 HV{sub 5} and the tensile strength 300 MPa. T6 heat treatments were performed with solutionisation at 450 °C for 30 min and 10 h. In both cases the ageing time was set as 18 h at 120 °C. The heat treatments led to an increase in average tensile strength up to 495 MPa. Transmission Electron Microscopy (TEM) analysis enabled the identification of precipitates of the metastable dispersoids of L1{sub 2}–Al{sub 3} (Zr, Sc) and η′ (MgZn{sub 2}) phases in the alloy after the thixoforming and T6 treatment. The measurements of rheological properties of 7075Al alloy with Sc and Zr additions in the semi-solid range indicated an increase of particle size and spheroidization leading to an observable decrease of viscosity during isothermal shearing. A shear rate jump experiment showed that with increasing shear rate the viscosity rapidly falls.

  6. Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intake.

    Science.gov (United States)

    Dess, Nancy K; Chapman, Clinton D; Monroe, Derek

    2009-03-01

    Mammals' affinity for sweet tastes exists alongside dramatic variation among species and individuals in responses to sweeteners. The present paper focused on consumption by Occidental High- (HiS) and Low-Saccharin (LoS)-consuming rats in 23-h 2-bottle tests of 2 sweeteners for which few data from rats are available: SC45647 and sucralose. Every HiS and LoS rat preferred SC45647 to water at every concentration, with HiS rats consuming it more avidly. Most HiS rats preferred sucralose to water at one or more concentrations; some HiS rats and most LoS rats avoided sucralose at every concentration. However, both HiS and LoS rats preferred a sucralose-maltodextrin mixture (Splenda) to water; thus, Splenda's "bulking" ingredient maltodextrin transforms highly variable responses to sucralose into a relatively homogeneous preference for the product. Implications for the study of variation in sweet taste are discussed. PMID:19129238

  7. SPACE-R nuclear power system SC-320 thermionic fuel element performance tests

    International Nuclear Information System (INIS)

    In 1993 and 1994, the Russian Scientific Research Institute NII NPO ''LUCH'' and Space Power, Inc., (SPI), of San Jose, California, developed a prototype of the single-cell thermionic fuel element (TFE) for the SPACE-R space nuclear power system (NPS). The SPACE-R system was designed as a part of the US Department of Energy's (DOE) Space Reactor Development Program to develop a long life, space reactor system capable of supplying up to 40 kW(e) output power. The jointly developed SC-320 TFE is a prototype of the next generation thermionic converter for nuclear applications in space. This paper presents the results of the initial demonstration tests and subsequent parametric evaluations conducted on the SC-320 TFE as compared to the calculated performance characteristics. The demonstration tests were conducted jointly by Russian and American specialists at the Thermionic Evaluation Facility (TEF) at the New Mexico Engineering Research Institute (NMERI) of the University of New Mexico in Albuquerque

  8. Virtual microscopy in medical research: Open European Nephrology Science Center (OpEN.SC)

    Science.gov (United States)

    Schrader, Thomas; Beil, Michael; Schmidt, Danilo; Dietel, Manfred; Lindemann, Gabriela

    2007-03-01

    The amount and heterogeneity of data in biomedical research, notably in transnational research, requires new methods for the collection, presentation and analysis of information. Important data from laboratory experiments as well as patient trials are available as images. Thus, the integration and processing of image data represent a crucial component of information systems in biomedical research. The Charité Medical School in Berlin has established a new information service center for kidney diseases and transplantation (Open European Nephrology Science Centre - OpEN.SC) together with the German Research Agency (DFG). The aims of this project are (i) to improve the availability of raw data, (ii) to establish an infrastructure for clinical trials, (iii) to monitor the occurrence of rare disease patterns and (iv) to establish a quality assurance system. Major diagnostic procedures in medicine are based on the processing and analysis of image data. In diagnostic pathology, the availability of automated slide scanners provide the opportunity to digitize entire microscopic slides. The processing, presentation and analysis of these image data are called virtual microscopy. The integration of this new technology into the OpEN.SC system and the link to other heterogeneous data of individual patients represent a major technological challenge. Thus, new ways in communication between clinical and scientific partners have to be established and will be promoted by the project. The technological basis of the repository are web services for a scalable and adaptable system. HL7 and DICOM are considered the main medical standards of communication.

  9. SC2IT: a cloud computing interface that makes computational science available to non-specialists

    Science.gov (United States)

    Jorissen, Kevin; Vila, Fernando; Rehr, John

    2012-10-01

    Computational work is a vital part of much scientific research. In materials science research in particular, theoretical models are usually needed to understand measurements. There is currently a double barrier that keeps a broad class of researchers from using state-of-the-art materials science (MS) codes: the software typically lacks user-friendliness, and the hardware requirements can demand a significant investment, e.g. the purchase of a Beowulf cluster. Scientific Cloud Computing (SCC) has the potential to breach this barrier and make computational science accessible to a wide class of non-specialists scientists. We present a platform, SC2IT, that enables seamless control of virtual compute clusters in the Amazon EC2 cloud and is designed to be embedded in user-friendly Java GUIs. Thus users can create powerful High-Performance Computing systems with preconfigured MS codes in the cloud with a single mouse click. We present applications of our SCC platform to the materials science codes FEFF9, WIEN2k, and MEEP-mpi. SC2IT and the paradigm described here are applicable to other fields of research beyond materials science, although the computational performance of Cloud Computing may vary with the characteristics of the calculations.

  10. Electronic, structural, and elastic properties of metal nitrides XN (X = Sc, Y): A first principle study

    Science.gov (United States)

    Ekuma, Chinedu E.; Bagayoko, Diola; Jarrell, Mark; Moreno, Juana

    2012-09-01

    We utilized a simple, robust, first principle method, based on basis set optimization with the BZW-EF method, to study the electronic and related properties of transition metal mono-nitrides: ScN and YN. We solved the KS system of equations self-consistently within the linear combination of atomic orbitals (LCAO) formalism. It is shown that the band gap and low energy conduction bands, as well as elastic and structural properties, can be calculated with a reasonable accuracy when the LCAO formalism is used to obtain an optimal basis. Our calculated, indirect electronic band gap (E^Γ -X_g) is 0.79 (LDA) and 0.88 eV (GGA) for ScN. In the case of YN, we predict an indirect band gap (E^Γ -X_g) of 1.09 (LDA) and 1.15 eV (GGA). We also calculated the equilibrium lattice constants, the bulk moduli (Bo), effective masses, and elastic constants for both systems. Our calculated values are in excellent agreement with experimental ones where the latter are available.

  11. Electronic, structural, and elastic properties of metal nitrides XN (X = Sc, Y: A first principle study

    Directory of Open Access Journals (Sweden)

    Chinedu E. Ekuma

    2012-09-01

    Full Text Available We utilized a simple, robust, first principle method, based on basis set optimization with the BZW-EF method, to study the electronic and related properties of transition metal mono-nitrides: ScN and YN. We solved the KS system of equations self-consistently within the linear combination of atomic orbitals (LCAO formalism. It is shown that the band gap and low energy conduction bands, as well as elastic and structural properties, can be calculated with a reasonable accuracy when the LCAO formalism is used to obtain an optimal basis. Our calculated, indirect electronic band gap (EΓ−Xg is 0.79 (LDA and 0.88 eV (GGA for ScN. In the case of YN, we predict an indirect band gap (EΓ−Xg of 1.09 (LDA and 1.15 eV (GGA. We also calculated the equilibrium lattice constants, the bulk moduli (Bo, effective masses, and elastic constants for both systems. Our calculated values are in excellent agreement with experimental ones where the latter are available.

  12. {sup 48}Sc as a calibration source for the SNO+ experiment

    Energy Technology Data Exchange (ETDEWEB)

    Boeltzig, Axel; Barros, Nuno; Krueger, Felix; Lozza, Valentina; Neumann, Laura; Krosigk, Belina von; Zuber, Kai [TU Dresden (Germany)

    2012-07-01

    SNO+ (Sudbury Neutrino Observatory Plus Scintillator) is the successor of the SNO experiment, and currently under construction near Sudbury, Canada. Located in a mine 2000 m underground (equivalent to a shielding of about 6000 m of water), SNO+ will be a low-background experiment studying different aspects of neutrinos. Several sources will be employed for the detector's calibration, which is scheduled to start in mid-2013. One of the sources under development at TU Dresden uses the {gamma} rays following the {beta} decay of {sup 48}Sc. The sum of the {gamma} energies for the main decay branch is close to the Q value of the double beta decay of {sup 150}Nd, which is planned to be measured in the second phase of SNO+. Due to the half life of only 43.67(9) h, {sup 48}Sc has to be produced shortly before the calibration. Safety, radiopurity and cleanliness are further important issues for the application of a source in a low-background experiment like SNO+. The design of the source, its production and the current status of its development are presented.

  13. Compton X-Ray Generation at the KAERI SC RF LINAC

    CERN Document Server

    Park, S H; Jeong, Y U; Lee, B C; Lee, K

    2005-01-01

    The KAERI SC RF linac with one 352 MHz cryomodule is routinely operating at 10 MeV. The maximum accelerating gradient achieved so far is about 7.7 MV/m and is expected to increase up to 9 MV/m, if thermal loss and/or vibration instability is sufficiently suppressed. As a next step, we plan to generate Compton X-rays using external lasers at the straight section, just after the SC linac. This beamline will be relocated to downstream next to undulator beamline for a FEL, when the recirculating beamline is built. In this presentation, we estimate the parameters of Compton X-rays at a given system and suggest the new scheme to increase the flux, or to generate fs X-ray pulses using electron beams with a few tens ps pulse duration, using an intense ultra-short laser. We discussed a coherent condition for Relativistic Nonlinear Thomson Scattered (RNTS) radiation (or Nonlinear Compton Scattered radiation).

  14. Al-Mg-Mn-Sc-Zr合金的断裂韧性%Fracture toughness of Al-Mg-Mn-Sc-Zr alloy

    Institute of Scientific and Technical Information of China (English)

    张飞鹏; 黄晓亚; 徐开东; 房慧; 王新练; 刘雅妹; 张坤书

    2013-01-01

    Plane strain fracture toughness KIC of Al-4.9Mg-0.6Mn-0.2Sc-0.1Zr alloy hot-rolled plate was measured by three points bending samples in L-T and T-L directions.Fracture morphology of the alloy was analyzed by SEM and TEM .The results show that the values of KIC in L-T and T-L directions are 32.66 MPa· m1/2 and 32.03 MPa· m1/2 respectively, which have a discrepancy of 2%, so the plane strain fracture toughness KIC of the alloy hot-rolled plate has weak anisotropy .The facture surfaces in L-T and T-L directions are composed by dimples and tear ridges .Dimple-type plastic fracture mode shows relatively high toughness of the alloy .Crack growth direction in T-L direction parallels to the rolling direction , and crack growths along fracture channel is formed by second-phase particles , so dimples arrangement on the fracture surface has obvious directionality .Crack growth direction in L-T direction is perpendicular to the rolling direction, so directionality of dimples arrangement in L-T direction is weak.Coarse Al6Mn as crack origins is detrimental for the fracture toughness.Micro-meter Al6Mn particles can cause micro-cracks as well.Nano-meter Al3Sc particles stabilize sub-structures by pinning dislocations and grain boundaries and reduce the dislocation density in front of the sub -grain boundaries , so the fracture toughness of the alloy hot-rolled plate is improved .%采用标准三点弯曲试样测试了Al-4.9Mg-0.6Mn-0.2Sc-0.1Zr合金热轧板L-T和T-L取向平面应变断裂韧度KIC ,并对试样断口进行SEM和TEM分析。结果表明,Al-4.9Mg-0.6Mn-0.2Sc-0.1Zr合金热轧板L-T和T-L取向KIC值分别为32.66 MPa· m1/2和32.03 MPa· m1/2,两者相差2%,表明试验合金平面应变断裂韧性各向异性差别较小。 L-T和T-L取向的断口表面主要由韧窝和撕裂棱组成,属于韧窝型塑性断裂,说明试验合金韧性比较高。 T-L取向断面裂纹的扩展方向与轧制方向一致,裂纹沿着

  15. Study of Microbiologically Induced Corrosion Action on Al-6Mg-Zr and Al-6Mg-Zr-Sc

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The corrosion behaviors of Al-6Mg-Zr and Al-6Mg-Zr-Sc in the sulfate-reducing bacteria (SRB) solution in anaerobic environment were studied using electrochemical, microbiological, and surface analysis methods. It was found that the oxide film was more compact owing to the addition of Sc resulting in the open circuit potential shifting by about 100mV positively. On the other hand, it was seen that the pitting sensitivity of Al-6Mg-Zr-Sc alloy in SRB solution decreased and its microbiologically influenced corrosion resistance was improved. Pitting corrosion occurring on the surface of the two alloys under the comprehensive action of the metabolism of SRB was observed by SEM. It was obtained by EDS that the corrosion degree increased with time and corrosion was furthered by deposition of the product.

  16. Nd 3+—Cr 3+ pairs in Gd 3Sc 2Ga 3O 12 garnet crystals

    Science.gov (United States)

    Han, T. P. J.; Scott, M. A.; Jaqué, F.; Gallagher, H. G.; Henderson, B.

    1993-06-01

    Several crystals of Gd 3Sc 2Ga 3O 12 (GSGG) with different concentrations of Nd 3+ and Cr 3+ ions have been grown using the Czochralski technique. Optical absorption and site-selective luminescence spectra have been measured in the wavelength range 350-900 nm at low temperatures (15-77 K). These spectral reveal the presence of Nd 3+ ions in two different crystal field sites. Some Nd 3+ ions substitute for Gd 3+ ions in unit cells in which the central octahedral site is occupied by Sc 3+ ions. However, in a significant fraction of unit cells containing Nd 3+ the central octahedral site is occupied by Cr 3+ ions. These centres are labelled Nd 3+ (Sc 3+ and Nd 3+ (Cr 3+), respectively. The spectroscopic characteristics of these perturbed Nd 3+ centres are reported and their relevance to the enhanced Nd 3+ laser efficiency of Cr 3+:Nd 3+:GSGG relative to Nd 3+:GSGG is discussed.

  17. High strength aluminum cast alloy: A Sc modification of a standard Al–Si–Mg cast alloy

    International Nuclear Information System (INIS)

    A standard Aluminum–Silicon–Magnesium cast alloy (A357 foundry alloy without Beryllium) modified with different weight percentages of Scandium (Sc), has been studied to evaluate the effects of Sc contents on microstructure and strength. Study has been conducted under optimized parameters of melting, casting and heat treatment. Characterization techniques like optical microscopy, SEM, TEM and tensile testing were employed to analyze the microstructure and mechanical properties. Results obtained in this research indicate that with the increase of Sc contents up to 0.4 wt%, grain size is decreased by 80% while ultimate tensile strength and hardness are increased by 28% and 19% respectively. Moreover along with the increase in strength, elongation to failure is also increased up to 165%. This is quite interesting behavior because usually strength and ductility have inverse relationship

  18. SYNTHESIS AND CHARACTERIZATION OF NOVEL CHIRAL SMECTIC C(Sc*) PHASE SHISH-KEBAB TYPE LIQUID CRYSTALLINE BLOCK COPOLYMERS

    Institute of Scientific and Technical Information of China (English)

    Shi-jun Zheng; Zi-fa Li; Shu-yuan Zhang; Shao-kui Cao; Ming-sheng Tang; Qiu-jun Fen; Qi-feng Zhou

    1999-01-01

    A new series of chiral shish-kebab type liquid crystal block copolymers that form the smectic C(Sc*) phase was synthesized by solution polycondensation. The copolymers were characterized by GPC,DSC, TG, POM, X-ray diffraction and polarimeter. The copolymers 7 entered into liquid crystal phase when they were heated to their melting temperatures (Tm) and the copolymers 8 were in liquid crystal phase at room temperature with low viscosities. The smectic sanded texture or focal-conic texture were observed on POM.All the chiral block copolymers showed high optical activity. No racemization has happened. Temperaturevariable X-ray diffraction study together with POM and polarimetric analysis realized that they are chiral smectic C(Sc*) phase. Thus we offer in this report the first example of shish-kebab type liquid crystal block copolymers that form a chiral smectic C(Sc*) phase. The variation of melting and isotropization temperatures with molecular structure was also discussed.

  19. Charge Transfer for Reactions of Sc3+ with N2 and H2 at Electron-volt Energy

    Institute of Scientific and Technical Information of China (English)

    CAO Li; JIANG Yu-Rong; NIE Zong-Xiu; LI Jiao-Mei; GAO Ke-Lin

    2001-01-01

    The charge transfer rate coefficients for reactions of Sc3+ with N2 and H2 have been measured at the meancollision energy of 4.2 Ev. The rate coefficients are derived from the decay rate ofion signals by using ion storagein a radio frequency ion trap. The rate coefficients are 8.18(0.18) × 10-10cm3.s-1 at Tequiv ≈ 1.26 × 104K forSc3+ with N2 and 1.44(0.39) × 10-9 cm3.s-1 at Tequiv ≈ 1.67 × 103 K for Sc3+ with H2, respectively. Both resultsare comparablewith the Langevin rate coefficients.

  20. Magnetism in Sc-doped ZnO with zinc vacancies: A hybrid density functional and GGA + U approaches

    KAUST Repository

    Kanoun, Mohammed

    2012-04-01

    We investigate the zinc vacancy effects on the electronic structures and magnetic properties of Sc-doped ZnO, by performing first-principles calculations within both GGA + U and Heyd-Scuseria-Ernzerhof hybrid functional methods. We find that Sc impurities stabilize considerably Zn vacancies. The electronic and magnetic analysis shows a half metallic ferromagnetic character with a total magnetic moment of 2.01 μ B. The magnetism mainly stems from the O 2p states around the Zn vacancies. Calculations with the hybrid density functional agree with the GGA + U results but give an accurate description of the electronic structure for pure ZnO and Sc-doped ZnO with Zn vacancies. © 2012 Elsevier B.V. All rights reserved.

  1. The first principle study of Ni{sub 2}ScGa and Ni{sub 2}TiGa

    Energy Technology Data Exchange (ETDEWEB)

    Özduran, Mustafa [Ahi Evran Üniversitesi Fen Edebiyat Fakültesi Fizik Bölümü, Kırşehir (Turkey); Turgut, Kemal [Yüksek Lisans Öğrencisi, Kırşehir (Turkey); Arikan, Nihat [Ahi Evran Üniversitesi Eğitim Fakültesi İlköğretim Bölümü, Kırşehir (Turkey); İyigör, Ahmet; Candan, Abdullah [Ahi Evran Üniversitesi Merkezi Araştırma Laboratuvarı, Kırşehir (Turkey)

    2014-10-06

    We computed the electronic structure, elastic moduli, vibrational properties, and Ni{sub 2}TiGa and Ni{sub 2}ScGa alloys in the cubic L2{sub 1} structure. The obtained equilibrium lattice constants of these alloys are in good agreement with available data. In cubic systems, there are three independent elastic constants, namely C{sub 11}, C{sub 12} and C{sub 44}. We calculated elastic constants in L2{sub 1} structure for Ni{sub 2}TiGa and Ni{sub 2}ScGa using the energy-strain method. The electronic band structure, total and partial density of states for these alloys were investigated within density functional theory using the plane-wave pseudopotential method implemented in Quantum-Espresso program package. From band structure, total and projected density of states, we observed metallic characters of these compounds. The electronic calculation indicate that the predominant contributions of the density of states at Fermi level come from the Ni 3d states and Sc 3d states for Ni{sub 2}TiGa, Ni 3d states and Sc 3d states for Ni{sub 2}ScGa. The computed density of states at Fermi energy are 2.22 states/eV Cell for Ni{sub 2}TiGa, 0.76 states/eV Cell for Ni{sub 2}ScGa. The vibrational properties were obtained using a linear response in the framework at the density functional perturbation theory. For the alloys, the results show that the L2{sub 1} phase is unstable since the phonon calculations have imagine modes.

  2. Selection of anti-sulfadimidine specific ScFvs from a hybridoma cell by eukaryotic ribosome display.

    Directory of Open Access Journals (Sweden)

    Yonghua Qi

    Full Text Available BACKGROUND: Ribosome display technology has provided an alternative platform technology for the development of novel low-cost antibody based on evaluating antibiotics derived residues in food matrixes. METHODOLOGY/PRINCIPAL FINDINGS: In our current studies, the single chain variable fragments (scFvs were selected from hybridoma cell lines against sulfadimidine (SM(2 by using a ribosome library technology. A DNA library of scFv antibody fragments was constructed for ribosome display, and then mRNA-ribosome-antibody (MRA complexes were produced by a rabbit reticulocyte lysate system. The synthetic sulfadimidine-ovalbumin (SM(2-OVA was used as an antigen to pan MRA complexes and putative scFv-encoding genes were recovered by RT-PCR in situ following each panning. After four rounds of ribosome display, the expression vector pCANTAB5E containing the selected specific scFv DNA was constructed and transformed into Escherichia coli HB2151. Three positive clones (SAS14, SAS68 and SAS71 were screened from 100 clones and had higher antibody activity and specificity to SM(2 by indirect ELISA. The three specific soluble scFvs were identified to be the same molecular weight (approximately 30 kDa by Western-blotting analysis using anti-E tag antibodies, but they had different amino acids sequence by sequence analysis. CONCLUSIONS/SIGNIFICANCE: The selection of anti-SM(2 specific scFv by in vitro ribosome display technology will have an important significance for the development of novel immunodetection strategies for residual veterinary drugs.

  3. Neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer

    International Nuclear Information System (INIS)

    The purpose of this study was to examine the safety and feasibility of a novel protocol of neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer. A total of 56 patients with lower rectal cancer of cT3N1M0 (Stage III b) was treated with SC-HART followed by radical surgery, and were analyzed in the present study. SC-HART was performed with a dose of 2.5 Gy twice daily, with an interval of at least 6 hours between fractions, up to a total dose of 25 Gy (25 Gy in 10 fractions for 5 days) combined with S-1 for 10 days. Radical surgery was performed within three weeks following the end of the SC-HART. The median age was 64.6 (range, 39-85) years. The median follow-up term was 16.3 (range, 2-53) months. Of the 56 patients, 53 (94.4%) had no apparent adverse events before surgery; 55 (98.2%) completed the full course of neoadjuvant therapy, while one patient stopped chemotherapy because of Grade 3 gastrointestinal toxicity (CTCAE v.3). The sphincter preservation rate was 94.6%. Downstaging was observed in 45 patients (80.4%). Adjuvant chemotherapy was administered to 43 patients (76.8%). The local control rate, disease-free survival rate and disease-specific survival rate were 100%, 91.1% and 100%, respectively. To conclude, SC-HART combined with S-1 for locally advanced rectal cancer was well tolerated and produced good short-term outcomes. SC-HART therefore appeared to have a good feasibility for use in further clinical trials. (author)

  4. Neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer.

    Science.gov (United States)

    Doi, Hiroshi; Beppu, Naohito; Odawara, Soichi; Tanooka, Masao; Takada, Yasuhiro; Niwa, Yasue; Fujiwara, Masayuki; Kimura, Fumihiko; Yanagi, Hidenori; Yamanaka, Naoki; Kamikonya, Norihiko; Hirota, Shozo

    2013-11-01

    The purpose of this study was to examine the safety and feasibility of a novel protocol of neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer. A total of 56 patients with lower rectal cancer of cT3N1M0 (Stage III b) was treated with SC-HART followed by radical surgery, and were analyzed in the present study. SC-HART was performed with a dose of 2.5 Gy twice daily, with an interval of at least 6 hours between fractions, up to a total dose of 25 Gy (25 Gy in 10 fractions for 5 days) combined with S-1 for 10 days. Radical surgery was performed within three weeks following the end of the SC-HART. The median age was 64.6 (range, 39-85) years. The median follow-up term was 16.3 (range, 2-53) months. Of the 56 patients, 53 (94.4%) had no apparent adverse events before surgery; 55 (98.2%) completed the full course of neoadjuvant therapy, while one patient stopped chemotherapy because of Grade 3 gastrointestinal toxicity (CTCAE v.3). The sphincter preservation rate was 94.6%. Downstaging was observed in 45 patients (80.4%). Adjuvant chemotherapy was administered to 43 patients (76.8%). The local control rate, disease-free survival rate and disease-specific survival rate were 100%, 91.1% and 100%, respectively. To conclude, SC-HART combined with S-1 for locally advanced rectal cancer was well tolerated and produced good short-term outcomes. SC-HART therefore appeared to have a good feasibility for use in further clinical trials. PMID:23658415

  5. Scandium Selenophosphates: Structure and Properties of K4Sc2(PSe4)2(P2Se6).

    Science.gov (United States)

    Syrigos, Jonathan C; Kanatzidis, Mercouri G

    2016-05-01

    The new compound K4Sc2P4Se14 was synthesized via the polychalcogenide flux method. It crystallizes in the space group C2/c, and the structure is composed of (1)/∞[Sc2P4Se14(4-)] chains that are separated by K(+) cations. The structural motif features two [PSe4](3-) units and one [P2Se6](4-) unit bridging the Sc centers and has not been reported for any other compound. The (1)/∞[Sc2P4Se14(4-)] chains pack in a crosshatched pattern perpendicular to the c axis of the crystal, forming channels for half of the K(+) atoms while the other half occupy empty space between the chains. The orange-yellow crystals of K4Sc2P4Se14 are air-sensitive and gradually turn red over the course of a couple hours. The band gap of the phase is 2.25(2) eV, and Raman spectroscopy shows the symmetric stretches of the selenophosphate groups to be at 231 and 216 cm(-1) for the [PSe4](3-) and [P2Se6](4-) units, respectively. Solid-state (31)P MAS NMR of K4Sc2P4Se14 shows two prominent peaks at 11.31 and -23.07 ppm and one minor peak at -106.36 ppm, most likely due to degradation of the product or an unknown second phase. PMID:27078201

  6. Effects of zirconium element on the microstructure and deuterium retention of W-Zr/Sc2O3 composites.

    Science.gov (United States)

    Chen, Hongyu; Luo, Laima; Chen, Jingbo; Zan, Xiang; Zhu, Xiaoyong; Xu, Qiu; Luo, Guangnan; Chen, Junling; Wu, Yucheng

    2016-01-01

    Dense W and W-Zr composites reinforced with Sc2O3 particles were produced through powder metallurgy and subsequent spark plasma sintering (SPS) at 1700 °C and 58 MPa. Results showed that the W-1vol.%Zr/2vol.%Sc2O3 composites exhibited optimal performance with the best relative density of up to 98.93% and high Vickers microhardness of approximately 583 Hv. The thermal conductivity of W-Zr/Sc2O3 composites decreased initially and then increased as the Zr content increased. The moderate Zr alloying element could combine well with Sc2O3 particles and W grains and form a solid solution. However, excess Zr element leads to agglomeration in the grain boundaries. W-1vol.%Zr/2vol.%Sc2O3 composite had a good deuterium irradiation resistance very closing to pure tungsten compared with the other Zr element contents of composites. Under 500 K, D2 retention and release of them were similar to those of commercial tungsten, even lower between 400 K to 450 K. Pre-irradiation with 5 keV-He(+) ions to a fluence of 1 × 10(21) He(+)/m(2) resulted in an increase in deuterium retention (deuterium was implanted after He(+) irradiation), thereby shifting the desorption peak to a high temperature from 550 K to 650 K for the W-1vol.%Zr/2vol.%Sc2O3 composite. PMID:27597314

  7. Thermoelectric properties of epitaxial ScN films deposited by reactive magnetron sputtering onto MgO(001) substrates

    International Nuclear Information System (INIS)

    Epitaxial ScN(001) thin films were grown on MgO(001) substrates by dc reactive magnetron sputtering. The deposition was performed in an Ar/N2 atmosphere at 2 × 10−3 Torr at a substrate temperature of 850 °C in a high vacuum chamber with a base pressure of 10−8 Torr. In spite of oxygen contamination of 1.6 ± 1 at. %, the electrical resistivity, electron mobility, and carrier concentration obtained from a typical film grown under these conditions by room temperature Hall measurements are 0.22 mΩ cm, 106 cm2 V−1 s−1, and 2.5 × 1020 cm−3, respectively. These films exhibit remarkable thermoelectric power factors of 3.3–3.5 × 10−3 W/mK2 in the temperature range of 600 K to 840 K. The cross-plane thermal conductivity is 8.3 W/mK at 800 K yielding an estimated ZT of 0.3. Theoretical modeling of the thermoelectric properties of ScN calculated using a mean-free-path of 23 nm at 300 K is in very good agreement with the experiment. These results also demonstrate that further optimization of the power factor of ScN is possible. First-principles density functional theory combined with the site occupancy disorder technique was used to investigate the effect of oxygen contamination on the electronic structure and thermoelectric properties of ScN. The computational results suggest that oxygen atoms in ScN mix uniformly on the N site forming a homogeneous solid solution alloy. Behaving as an n-type donor, oxygen causes a shift of the Fermi level in ScN into the conduction band without altering the band structure and the density of states.

  8. Development of Field-Controlled Smart Optic Materials (ScN, AlN) with Rare Earth Dopants

    Science.gov (United States)

    Kim, Hyun-Jung; Park, Yeonjoon; King, Glen C.; Choi, Sang H.

    2012-01-01

    The purpose of this investigation is to develop the fundamental materials and fabrication technology for field-controlled spectrally active optics that are essential for industry, NASA, and DOD applications such as: membrane optics, filters for LIDARs, windows for sensors, telescopes, spectroscopes, cameras, flat-panel displays, etc. ScN and AlN thin films were fabricated on c-axis Sapphire (0001) or quartz substrate with the RF and DC magnetron sputtering. The crystal structure of AlN in fcc (rocksalt) and hcp (wurtzite) were controlled. Advanced electrical characterizations were performed, including I-V and Hall Effect Measurement. ScN film has a free carrier density of 5.8 x 10(exp 20)/per cubic centimeter and a conductivity of 1.1 x 10(exp 3) per centimeter. The background ntype conductivity of as-grown ScN has enough free electrons that can readily interact with the photons. The high density of free electrons and relatively low mobility indicate that these films contain a high level of shallow donors as well as deep levels. Also, the UV-Vis spectrum of ScN and AlN thin films with rare earth elements (Er or Ho) were measured at room temperature. Their optical band gaps were estimated to be about 2.33eV and 2.24eV, respectively, which are obviously smaller than that of undoped thin film ScN (2.4eV). The red-shifted absorption onset gives direct evidence for the decrease of band gap (Eg) and the energy broadening of valence band states are attributable to the doping. As the doped elements enter the ScN crystal lattices, the localized band edge states form at the doped sites with a reduction of Eg. Using a variable angle spectroscopic ellipsometer, the decrease in refractive index with applied field is observed with a smaller shift in absorption coefficient.

  9. Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation

    OpenAIRE

    Benjamin J Tillotson; Goulatis, Loukas I.; Parenti, Isabelle; Duxbury, Elizabeth; Shusta, Eric V.

    2015-01-01

    The equilibrium binding affinity of receptor-ligand or antibody-antigen pairs may be modulated by protonation of histidine side-chains, and such pH-dependent mechanisms play important roles in biological systems, affecting molecular uptake and trafficking. Here, we aimed to manipulate cellular transport of single-chain antibodies (scFvs) against the transferrin receptor (TfR) by engineering pH-dependent antigen binding. An anti-TfR scFv was subjected to histidine saturation mutagenesis of a s...

  10. Moments of Macrodiversity SC Receiver with Two Microdiversity EGC Receivers over Gamma Shadowed Rician Multipath Fading Channel

    Directory of Open Access Journals (Sweden)

    Ilija Temelkovski

    2015-08-01

    Full Text Available SC macrodiversity system with dual EGC microdiversity receivers operating over shadowed multipath fading environment is considered. Received signal experiences correlated Gamma long term fading and Rician short term fading. SC macrodiversity receiver reduces Gamma large scale fading effects, while EGC microdiversity receivers mitigate short term fading effects on system performance. Closed form expressions for arbitrary order output moments of macrodiversity structure output signal is evaluated. Numerical results, obtained for arbitrary order output moments are presented graphically to show Gamma long term fading severity effect, correlation coefficient effects and Rician factor effect.

  11. Crystallographic information of intermediate phases in binary Mg-X (X=Sn, Y, Sc, Ag) alloys.

    Science.gov (United States)

    Liu, Dongyan; Dai, Xuefeng; Wen, Xiaohong; Qin, Gaowu; Meng, Xiangying

    2015-09-01

    The compositions and structures of thermodynamically stable or metastable precipitations in binary Mg-X (X=Sn, Y, Sc, Ag) alloys are predicted using ab-initio evolutionary algorithm. The geometry optimizations of the predicted intermetallic compounds are carried out in the framework of density functional theory (DFT) [1]. A complete list of the optimized crystallographic information (in cif format) of the predicted intermetallic phases is presented here. The data is related to "Predictions on the compositions, structures, and mechanical properties of intermediate phases in binary Mg-X (X=Sn, Y, Sc, Ag ) alloys" by Liu et al. [2]. PMID:26217787

  12. Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

    OpenAIRE

    Chen, Yunching; Zhu, Xiaodong; Zhang, Xiaoju; Liu, Bin; Huang, Leaf

    2010-01-01

    Targeted delivery of RNA-based therapeutics for cancer therapy remains a challenge. We have developed a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation modified with tumor-targeting single-chain antibody fragment (scFv) for systemic delivery of small interfering RNA (siRNA) and microRNA (miRNA) into experimental lung metastasis of murine B16F10 melanoma. The siRNAs delivered by the scFv targeted nanoparticles efficiently downregulated the target genes (c-Myc/MDM2/VEGF) in t...

  13. Impact of Reduction Parameters on the Initial Performance and Stability of Ni/(Sc)YSZ Cermet Anodes for SOFCs

    DEFF Research Database (Denmark)

    Ebbehøj, Søren Lyng; Ramos, Tania; Mogensen, Mogens Bjerg

    2012-01-01

    temperatures of 850 °C and 1000 °C was evaluated for tape-cast, thin electrolyte, Nickel/8 mol% Yttria-Stabilized Zirconia (Ni/8YSZ) or (Ni/10Sc1YSZ) symmetric cells. High temperature activation produced the lower Ohmic and polarization resistances related to Triple Phase Boundary (TPB) charge transfer...... processes for Ni/10Sc1YSZ cells. The Ni/8YSZ cells behaved oppositely with respect to reduction temperature. A hypothesis is proposed relating performance to variations in Ni microstructure, Ni/ceramic contacting and extent of TPB resulting from differences in reduction parameters. Further, the performance...

  14. Negative thermal expansion and broad band photoluminescence in a novel material of ZrScMo2VO12

    OpenAIRE

    Xianghong Ge; Yanchao Mao; Xiansheng Liu; Yongguang Cheng; Baohe Yuan; Mingju Chao; Erjun Liang

    2016-01-01

    In this paper, we present a novel material with the formula of ZrScMo2VO12 for the first time. It was demonstrated that this material exhibits not only excellent negative thermal expansion (NTE) property over a wide temperature range (at least from 150 to 823 K), but also very intense photoluminescence covering the entire visible region. Structure analysis shows that ZrScMo2VO12 has an orthorhombic structure with the space group Pbcn (No. 60) at room temperature. A phase transition from monoc...

  15. Crystal Growth and Properties of Co2+ doped Y3Sc2Ga3O12 Single Crystal

    Institute of Scientific and Technical Information of China (English)

    Guo Shiyi; Yuan Duorong; Shi Xuzhong; Cheng Xiufeng; Zhang Xiqing; Yu Fapeng

    2007-01-01

    Single crystal of cobalt (Co)-doped Y3Sc2Ga3O12 (YSGG) with the dimensions up to φ20×40mm3 and undoped YSGG crystal with the dimensions up to φ28×60mm3 have been grown using the Czochralski technique. The structure of the crystal was characterized by the X-ray powder diffraction (XRPD) method. The absorbance spectra of the crystal shows that it has strong absorption bands at 606 and 1540nm. The results indicate that the crystal Y3Sc2Ga3O12 may be a kind of good Q-switch material.

  16. Estudio sobre el uso del sistema de comunicación aumentativo y alternativo SC@UT

    OpenAIRE

    Espejo Cárdenas, Silvia; Carrillo Morales, Aurelia; Fernández López, Álvaro; Rodríguez Fórtiz, María José

    2009-01-01

    Se ha estudiado el uso del SCAA Sc@ut en aulas, y talleres de dos asociaciones, ASPROGRADES de Granada y APROMPSI de Linares, Jaén. Se han planteado dos hipótesis: (1) El uso de Sc@ut en adultos deficientes y en alumnos en edad escolar con todo tipo de patologías, mejora la comunicación, el desarrollo del lenguaje y por tanto el aprendizaje, (2) La mejora de la comunicación lleva consigo la disminución de las conductas disruptivas y desafiantes. Han participado 67 s...

  17. Production and Evaluation of Immunoreactivity of Poly Lysine-Tagged Single Chain Fragment Variable (ScFv) Lym-1 Antibody for Direct Conjugation to Fluorescence Dye

    International Nuclear Information System (INIS)

    Small size of recombinant scFv antibody has many advantages such as rapid blood clearances and improved targeting antibodies to tumor region. On the other hand owing to small size, number of amino group is insufficient in conjugation with chelator and fluorescence labeling. This study is to introduce poly lysine tag to the C-terminal end of scFv lym-1 sequence for fluorescence chelator conjugation. Poly lysine scFv lym-1 gene, cloned into pET-22b (+) vector, was expressed in E. coli BL21 (DE3) strain. Antibody purification was performed with Ni-NTA column and then size exclusion column chromatography. Expression and purification levels of poly lysine tagged scFv lym-1 antibody were confirmed by western blot analysis. I-124, I-125, I-131 and Tc-99m were used for radiolabeling of purified poly lysine scFv lym-1. Flow cytometry analysis of FITC conjugated poly lysine scFv lym-1 was performed for confirmation of immunoreactivity of human Burkitt's lymphoma cells. Poly lysine scFv lym-1 antibody was purified through two steps and identified as molecular weight of 48 KDa. Radiolabeling yields of I-124, I-125, I-131 and Tc-99m into poly lysine scFv lym-1 were >99%, >99%, >95% and >99%, respectively. Flow cytometry analysis of poly lysine scFv and scFv lym-1 was showed similar immunoreactivity to human Burkitt's lymphoma cells. Poly lysine tag was useful for the sufficient number of amino groups to scFv lym-1 antibody for chelator conjugation with minimizing loss of immunoreactivity

  18. Production and Evaluation of Immunoreactivity of Poly Lysine-Tagged Single Chain Fragment Variable (ScFv) Lym-1 Antibody for Direct Conjugation to Fluorescence Dye

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jae Ho; Choi, Tae Hyun; Woo, Kwang Sun; Chung, Wee Sup; Kang, Joo Hyun; Jeong, Su Young; Choi, Chang Woon; Lim, Sang Moo; Cheon, Gi Jeong [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2009-10-15

    Small size of recombinant scFv antibody has many advantages such as rapid blood clearances and improved targeting antibodies to tumor region. On the other hand owing to small size, number of amino group is insufficient in conjugation with chelator and fluorescence labeling. This study is to introduce poly lysine tag to the C-terminal end of scFv lym-1 sequence for fluorescence chelator conjugation. Poly lysine scFv lym-1 gene, cloned into pET-22b (+) vector, was expressed in E. coli BL21 (DE3) strain. Antibody purification was performed with Ni-NTA column and then size exclusion column chromatography. Expression and purification levels of poly lysine tagged scFv lym-1 antibody were confirmed by western blot analysis. I-124, I-125, I-131 and Tc-99m were used for radiolabeling of purified poly lysine scFv lym-1. Flow cytometry analysis of FITC conjugated poly lysine scFv lym-1 was performed for confirmation of immunoreactivity of human Burkitt's lymphoma cells. Poly lysine scFv lym-1 antibody was purified through two steps and identified as molecular weight of 48 KDa. Radiolabeling yields of I-124, I-125, I-131 and Tc-99m into poly lysine scFv lym-1 were >99%, >99%, >95% and >99%, respectively. Flow cytometry analysis of poly lysine scFv and scFv lym-1 was showed similar immunoreactivity to human Burkitt's lymphoma cells. Poly lysine tag was useful for the sufficient number of amino groups to scFv lym-1 antibody for chelator conjugation with minimizing loss of immunoreactivity

  19. ALERTES-SC3 Early Warning System prototype for South Iberian Peninsula: on-site approach.

    Science.gov (United States)

    Pazos, Antonio; Lopez de Mesa, Mireya; Gallego Carrasco, Javier; Martín Davila, José; Rioja del Rio, Carlos; Morgado, Arturo; Vera, Angel; Ciberia, Angel; Cabieces, Roberto; Strollo, Angelo; Hanka, Winfried; Carranza, Marta

    2016-04-01

    In recent years several Earthquake Early Warning Systems (EEWS) have been developed for different parts of the world. The area between SW Cape St. Vicente and the Strait of Gibraltar is one of the most seismically active zones in the Ibero-Maghrebian region, with predominantly moderate and superficial seismicity, but also big events with associated tsunamis are well documented in the area, like the 1755 Lisbon earthquake. In the frame of the ALERT-ES (2011-2013) and ALERTES-RIM (2014-2016) Spanish projects, the ALERTES-SC3 EEWS, regional approach, prototype has been developed at the Royal Spanish Navy Observatory (ROA) and is being tested in near real time for south Iberia. This prototype, based on the SeisComP3 software package, is largely based on algorithms derived from the analysis of the first seconds of the P wave records. Calculation of several parameters are carried out, mainly the characteristic period (τc) and the displacement peak (Pd), but also the velocity peak (Pv), the maximum period (τPmáx), among others. In order to warm the areas closest to the hypocentre, places located inside the "blind zone", a on-site EEWS has also been developed by ROA and integrated in the ALERTES-SC3 prototype. From the on-site approach, a warm level is declared from one station as a function of the estimated characteristic period (τc) and the displacement Peak (Pd), although the earthquake location and therefore the lead time available remains unknown. This on-site EEWS is being tested in several Western Mediterranean net (WM) stations as ARNO (Arenosillo, Huelva,Spain) or CHAS (Chafarinas island, North Africa, Spain). Also an on-site low cost station is being developed based in low cost accelerometers. In this work the current state of the on-site EEWS developed, its integration in the ALERTES-SC3 EEWS system and the low cost seismic stations are shown.

  20. l2b78sc.m77t - MGD77 data file for Geophysical data from field activity L-2B-78-SC in Southern California from 05/25/1978 to 05/29/1978

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry and magnetics data along with DGPS navigation data was collected as part of field activity L-2B-78-SC in Southern California from 05/25/1978...

  1. f184sc.m77t - MGD77 data file for Geophysical data from field activity F-1-84-SC in Southern California from 04/26/1984 to 05/21/1984

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry and magnetic data along with DGPS navigation data was collected as part of field activity F-1-84-SC in Southern California from 04/26/1984 to...

  2. Mechanical Properties Evaluation of Zr Addition in L12-Al3(Sc1- x Zr x ) Using First-Principles Calculation

    Science.gov (United States)

    Qian, Yi; Xue, Jilai; Wang, Zengjie; Yang, Zhenhai; Qian, Ping

    2016-05-01

    L12-Al3(Sc1- x Zr x ) can be used as a grain refiner and recrystallization inhibitor in forming and heat-treatment of wrought aluminum alloy. In this work, the mechanical properties of L12-Al3(Sc1- x Zr x ) (0 process optimization for Al alloys in forming and heat treatment.

  3. New Insights into the Negative Thermal Expansion: Direct Experimental Evidence for the "Guitar-String" Effect in Cubic ScF3.

    Science.gov (United States)

    Hu, Lei; Chen, Jun; Sanson, Andrea; Wu, Hui; Guglieri Rodriguez, Clara; Olivi, Luca; Ren, Yang; Fan, Longlong; Deng, Jinxia; Xing, Xianran

    2016-07-13

    The understanding of the negative thermal expansion (NTE) mechanism remains challenging but critical for the development of NTE materials. This study sheds light on NTE of ScF3, one of the most outstanding materials with NTE. The local dynamics of ScF3 has been investigated by a combined analysis of synchrotron-based X-ray total scattering, extended X-ray absorption fine structure, and neutron powder diffraction. Very interestingly, we observe that (i) the Sc-F nearest-neighbor distance strongly expands with increasing temperature, while the Sc-Sc next-nearest-neighbor distance contracts, (ii) the thermal ellipsoids of relative vibrations between Sc-F nearest-neighbors are highly elongated in the direction perpendicular to the Sc-F bond, indicating that the Sc-F bond is much softer to bend than to stretch, and (iii) there is mainly dynamically transverse motion of fluorine atoms, rather than static shifts. These results are direct experimental evidence for the NTE mechanism, in which the rigid unit is not necessary for the occurrence of NTE, and the key role is played by the transverse thermal vibrations of fluorine atoms through the "guitar-string" effect. PMID:27336200

  4. Complete Genome Sequence of Paenibacillus polymyxa SC2, a Strain of Plant Growth-Promoting Rhizobacterium with Broad-Spectrum Antimicrobial Activity ▿

    OpenAIRE

    Ma, Mingchao; Wang, Cuicui; Ding, Yanqin; Li, Li; Shen, Delong; Jiang, Xin; Guan, Dawei; Cao, Fengming; Chen, Huijun; Feng, Ruihua; Wang, Xuan; Ge, Yifan; Yao, Liangtong; Bing, Xiaohui; Yang, Xiaohong

    2010-01-01

    Paenibacillus polymyxa SC2 is an important plant growth-promoting rhizobacterium (PGPR). Here, we report the complete genome sequence of P. polymyxa SC2. Multiple sets of functional genes have been found in the genome. As far as we know, this is the first complete genome sequence of Paenibacillus polymyxa.

  5. Effect of minor Sc and Zr addition on grain refi nement of as-cast Al-Zn-Mg-Cu alloys

    Directory of Open Access Journals (Sweden)

    He Yongdong

    2009-08-01

    Full Text Available The optical microscopy and scanning electron microscopy as well as energy dispersive spectroscopy were employed to investigate the infl uence of joint addition of Sc and Zr on grain refi nement of Al-Zn-Mg-Cu alloys.Results show that the addition of 0.20% Sc has a little effect on grain refi nement because Sc is mainly dissolved into the matrix and hardly any primary Al3Sc particles are precipitated. The alloy with addition of 0.30% Sc and 0.16% Zr has more equiaxed grains than that of others, giving cast grain sizes as fi ne as 13 μm. This is because the Sc substitutes for Al atom in the Al-Zr crystal cell and forms Al-Sc-Zr unit cell, which grows and becomes Al3(Scx,Zr1-x particle, acting as a nucleus for the formation of α-Al. The addition of 0.04% Ti and 0.008% B makes the grain size drop from 250 μm to 50 μm. Its refi nement effect is less than the 13 μm achieved by the alloy including 0.30% Sc and 0.16% Zr.

  6. The regulatory effect of SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide) on stem cell factor induced migration of mast cells

    International Nuclear Information System (INIS)

    SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-]benzenesulfonamide; C16H11ClF3N3O2S), is a highly selective cyclooxygenase (COX)-2 inhibitor. Recently, there have been reports that SC-236 protects against cartilage damage in addition to reducing inflammation and pain in osteoarthritis. However, the mechanism involved in the inflammatory allergic reaction has not been examined. Mast cells accumulation can be related to inflammatory conditions, including allergic rhinitis, asthma, and rheumatoid arthritis. The aim of the present study is to investigate the effects of SC-236 on stem cell factor (SCF)-induced migration, morphological alteration, and cytokine production of rat peritoneal mast cells (RPMCs). We observed that SCF significantly induced the migration and morphological alteration. The ability of SCF to enhance migration and morphological alteration was abolished by treatment with SC-236. In addition, production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and vascular endothelial growth factor (VEGF) production induced by SCF was significantly inhibited by treatment with SC-236. Previous work has demonstrated that SCF-induced migration and cytokine production of mast cells require p38 MAPK activation. We also showed that SC-236 suppresses the SCF-induced p38 MAPK activation in RPMCs. These data suggest that SC-236 inhibits migration and cytokine production through suppression of p38 MAPK activation. These results provided new insight into the pharmacological actions of SC-236 and its potential therapeutic role in the treatment of inflammatory allergic diseases

  7. Effect of deformation structure on fatigue behavior of an Al-Mg-Sc alloy

    Science.gov (United States)

    Zhemchuzhnikova, Daria; Kaibyshev, Rustam

    2014-08-01

    Effect of initial grain size on fatigue behavior of an Al-6%Mg-0.35%Mn-0.2%Sc- 0.08%Zr-0.07%Cr alloy was examined. The initial CG microstructure with an average grain size of ~ 22 μm was manufactured by casting followed by solution treatment at 360 °C for 12 h. To produce the UFG condition, the alloy was subjected to equal-channel angular pressing (ECAP) at 320 °C up to a total strain of ~ 14. Extensive grain refinement provided the formation of fully recrystallized structure with an average grain size of 700 nm. It was shown that the formation of UFG structure provided +60% increases in yield stress and +25% increases in fatigue strength. Fundamentals of this effect of microstructure on the static strength, fatigue resistance and fracture modes are discussed.

  8. Effect of Grain Refinement on Jerky Flow in an Al-Mg-Sc Alloy

    Science.gov (United States)

    Mogucheva, Anna; Yuzbekova, Diana; Kaibyshev, Rustam; Lebedkina, Tatiana; Lebyodkin, Mikhail

    2016-05-01

    The influence of microstructure on the manifestations of the Portevin-Le Chatelier (PLC) effect was studied in an Al-Mg-Sc alloy with unrecrystallized, partially recrystallized, and fully recrystallized grain structures. It was found that the extensive grain refinement promotes plastic instability: the temperature-strain rate domain of the PLC effect becomes wider and the critical strain for the onset of serrations decreases. Besides, the amplitude of regular stress serrations observed at room temperature and an intermediate strain rate increases several times, indicating a strong increase of the contribution of solute solution hardening to the overall strength. Moreover, the grain refinement affects the usual sequence of the characteristic types of stress serrations, which characterize the dynamical mechanisms governing a highly heterogeneous unstable plastic flow. Finally, it reduces the strain localization and surface roughness and diminishes the difference between the surface markings detected in the necked area and in the region of uniform elongation.

  9. Christophe Apprill, Tango. Le couple, le bal et la scène

    OpenAIRE

    Célérier, Laure

    2011-01-01

    « On chuchote qu'il se danse les yeux dans les yeux, qu'il est né dans les bas-fonds et les bordels de Buenos Aires, » on murmure que « le tango est une danse de macho, qu'il est un désir horizontal exprimé à la verticale », écrit Christophe Apprill, sociologue autant que danseur, dans l'introduction de son ouvrage Tango - le couple, le bal et la scène, paru aux Editions Autrement en 2008. L'aura mystérieuse entourant la danse argentine du tango suscite d'innombrables légendes et mythologies....

  10. MAPEAMENTO DA SUSCEPTIBILIDADE A DESLIZAMENTOS NA BACIA HIDROGRÁFICA DO CAETÉ, ALFREDO WAGNER/SC

    Directory of Open Access Journals (Sweden)

    Leandro Redin Vestena

    2010-01-01

    Full Text Available Este artículo tiene como objetivo identifi car y mapear la susceptibilidad de deslizamientos de tierra en la cuenca hidrográfi ca del municipio de Caeté Alfredo Wagner/SC, región montañosa del Estado de Santa Catarina. Se utilizó el modelo SINMAP (Stability Index Mapping para determinar el indice de estabilidad de taludes por medio de la combinación de un modelo hidrológico con un de estabilidad de taludes. Los resultados obtenidos mostran la presencia de zonas con elevado grado de inestabilidad de las laderas y con grado de estabilidad intermedia, que pueden ser fácilmente alteradas por actividades humanas, principalmente por la eliminación de la cubertura vegetal. El conocimiento previo de las zonas susceptibles a deslizamientos y resbalos subvencionan acciones de prevención y mitigación.

  11. Optical and electronic properties of double perovskite Ba2ScSbO6

    Science.gov (United States)

    Ray, Rajyavardhan; Himanshu, A. K.; Lahiri, J.; Kumar, Uday; Sen, Pintu; Bandyopadhyay, S. K.; Sinha, T. P.

    2016-05-01

    The ordered double perovskite Ba2ScSbO6 (BSS) has been synthesized in polycrystalline form by solid state reaction at 1400 C for 72 Hrs. Structural characterization of the compound was done through X-ray diffraction (XRD) followed by Rietveld analysis. The crystal structure is cubic, with space group Fm-3m (No. 225) and lattice parameter, a = 8.20 Ǻ. Optical band-gap has been calculated using UV-Vis Spectroscopy and Kubelka-Munk (KM) function, yielding 4.23 eV. A detailed Ab-initio Density Functional Theory (DFT) study of the electronic properties has been carried out using the Full-Potential Linear Augmented Plane Wave (FP-LAPW) as implemented in WIEN2k. BSS is found to be a large band-gap insulator with potential technological applications.

  12. Infrared losses from a Na/Sc metal-halide high intensity discharge arc lamp

    International Nuclear Information System (INIS)

    A study of the near-infrared (IR) emission from the arc of a metal-halide high intensity discharge (MH-HID) lamp with a sodium/scandium chemistry is reported. Radiometrically calibrated spectra from 0.7 to 2.5 μm were recorded as a function of position on the arc tube of a 250 W lamp. These spectra were analysed to determine the relative densities of Na and Sc atoms and the arc temperature as a function of radius. Information from these spectra, combined with absorption measurements in the companion paper (Bonvallet and Lawler 2003), were used to determine the absolute output power in the near-IR from the MH-HID lamp

  13. Infrared losses from a Na/Sc metal-halide high intensity discharge arc lamp

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D J; Bonvallet, G A; Lawler, J E [Department of Physics, University of Wisconsin, 1150 University Avenue, Madison, WI 53706 (United States)

    2003-07-07

    A study of the near-infrared (IR) emission from the arc of a metal-halide high intensity discharge (MH-HID) lamp with a sodium/scandium chemistry is reported. Radiometrically calibrated spectra from 0.7 to 2.5 {mu}m were recorded as a function of position on the arc tube of a 250 W lamp. These spectra were analysed to determine the relative densities of Na and Sc atoms and the arc temperature as a function of radius. Information from these spectra, combined with absorption measurements in the companion paper (Bonvallet and Lawler 2003), were used to determine the absolute output power in the near-IR from the MH-HID lamp.

  14. Scrutation de scènes naturelles par un agent conversationnel animé

    OpenAIRE

    Picot, Antoine; Bailly, Gérard; Elisei, Frédéric; Raidt, Stephan

    2006-01-01

    Cet article présente un système de gestion du regard d'un agent conversationnel animé doté de capacités à percevoir l'environnement physique dans lequel il intervient. Ce système est inspiré des composantes connues de l'attention visuelle et intègre ses limitations en termes d'acuité, de sensibilité au mouvement, de mémoire à court-terme et de suivi de mouvements. Le but de ce couplage entre animation et analyse de scènes est de fournir à l'usager des gages de présence et d'attention aux chan...

  15. Ants of João da Cunha Island, SC, Brazil: composition and diversity

    Directory of Open Access Journals (Sweden)

    Ricardo Corbetta

    2005-05-01

    Full Text Available The ant species of João da Cunha Island, SC, were collected both manually and by the use of attractive baits of honey and sardine. The samples were taken at 10 sites, each having one bait of each type, totalling 20 samples in each collection. A total of 14 genera, 52 species and 5 subfamilies was sampled in one year of monthly sampling. The richest genera were Pheidole (16 species and Camponotus (9. The biological diversity values were high, and the ant fauna presented a strong seazonality on account of this diversity. The greatest similarity between seasons of the year was observed between spring and summer, followed by autumn and winter.

  16. Redesigning Introductory Science Courses to Teach Sustainability: Introducing the L(SC)2 Paradigm

    Science.gov (United States)

    Myers, J. D.; Campbell-Stone, E.; Massey, G.

    2008-12-01

    Modern societies consume vast quantities of Earth resources at unsustainable levels; at the same time, resource extraction, processing, production, use and disposal have resulted in environmental damage severe enough to threaten the life-support systems of our planet. These threats are produced by multiple, integrative and cumulative environmental stresses, i.e. syndromes, which result from human physical, ecological and social interactions with the environment in specific geographic places. In recent decades, recognition of this growing threat has lead to the concept of sustainability. The science needed to provide the knowledge and know-how for a successful sustainability transition differs markedly from the science that built our modern world. Sustainability science must balanced basic and applied research, promote integrative research focused on specific problems and devise a means of merging fundamental, general scientific principles with understanding of specific places. At the same time, it must use a variety of knowledge areas, i.e. biological systems, Earth systems, technological systems and social systems, to devise solutions to the many complex and difficult problems humankind faces. Clearly, sustainability science is far removed from the discipline-based science taught in most U.S. colleges. Many introductory science courses focus on content, lack context and do not integrate scientific disciplines. To prepare the citizens who will confront future sustainability issues as well as the scientists needed to devise future sustainability strategies, educators and scientists must redesign the typical college science course. A new course paradigm, Literacies and Scientific Content in Social Context (L(SC)2), is ideally suited to teach sustainability science. It offers an alternative approach to liberal science education by redefining and expanding the concept of the interdisciplinary course and merging it with the integrated science course. In addition to

  17. INTERVIEW WITH MRS. SIMONA CAROBENE, ADMINISTRATOR OF SC PROIECT MOZAIC SRL

    Directory of Open Access Journals (Sweden)

    Gheorghe Pascaru

    2013-12-01

    Full Text Available The mosaic factory, recorded at the Registry of Commerce Office in the month of April 2012 was created within a non-reimbursable European financed project and currently has the status of authorized protected unit. There are ten young people who were institutionalized and who have difficulties to become integrated in the social and professional life. The social enterprise SC Proiect Mozaic SRL is the result of a meeting between the social sector, the non-profit sector and the business sector because it has at its basis a partnership with an important group of companies from the field of constructions and interior design from Bucharest. In parallel with the activity of producing mosaic, the Mosaic project provides occasionally to its clients also services of products packaging and assembly.

  18. Multiuser subcarriers and bit allocation combining adaptive mapping for SC-FDMA system

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yu-mei; XIN Yu; YANG Da-cheng

    2008-01-01

    In this article, a multiuser single carrier frequency division multiple access (SC-FDMA) system is considered, based on which an adaptive subcarrier and bit allocation algorithm is investigated. The algorithm has been used to achieve a subcarrier mapping mode in this system, which combines the advantages of single- and multi-carrier transmissions, such as, low peak to average power ratio, orthogonality of signals of different users, and low complexity. Simulation results show that it has a similar performance as that of the adaptive allocation algorithm in the orthogonal frequency division multiple (OFDM) system and the proposed mapping mode has a performance gain over the two existing mapping modes at the link level.

  19. The spatial specificities of SC and ST population in Kolkata city: approaches, techniques and analysis

    Directory of Open Access Journals (Sweden)

    Mishra, Swasti Vardhan

    2012-06-01

    Full Text Available The paper aims at achieving two objectives, firstly, to acquaint the researchers in the field of spatial demography with the techniques of residential segregation; pattern of population distribution based on the concept of spatial statistics and secondly, the practical evaluation of the techniques through real life data. The study queries about any residential segregation and pattern of location of the scheduled caste (SC and the scheduled tribe (ST population in Kolkata city by concentrating on the measures of Entropy Index (EI, Atkinson’s Index, Absolute Centralization Index (ACE and the Global and Local Spatial Autocorrelation (SA measures of Moran’s I and LISA. The outcome of the study clarifies the fact that caste and race based segregation is being diluted in the wake of Indian urbanization and the spatial clustering tendency of the Concerned Social Group (CSG is as mild.

  20. Proton and oxide ion conductivity of doped LaScO3

    DEFF Research Database (Denmark)

    Lybye, D.; Bonanos, N.

    1999-01-01

    The conductivity of La0.9Sr0.1Sc0.9Mg0.1O3 has been studied by impedance spectroscopy in controlled atmospheres. The material was found to be a mixed conductor with p-type conduction at high oxygen partial pressures and a combined proton and oxide ion conductor at low oxygen partial pressures. At...... temperatures below 800 degrees C and low partial pressure of oxygen, proton conduction was dominant. Above this temperature, the ionic conductivity is dominated by oxide ion transport. The protonic transport number was estimated from the conductivities measured in dry and in water-moisturised gas. An isotope...... effect was observed using D-2/D2O in place of H-2/H2O. The oxygen transport number was estimated from this effect and from measurements in a two-chamber electrochemical cell. (C) 1999 Elsevier Science B.V. All rights reserved....