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Sample records for cellpro ceprate sc

  1. Pulsed SC Proton Linac

    OpenAIRE

    Ouchi, N.; Chishiro, E.; Tsukishima, C.; Mukugi, K.

    2000-01-01

    The superconducting (SC) proton linac is proposed in the JAERI/KEK Joint Project for a high-intensity proton accelerator in the energy region from 400 to 600 MeV. Highly stable fields in the SC cavities are required under the dynamic Lorentz force detuning. A new model describing the dynamic Lorentz detuning has been developed and the validity has been confirmed experimentally. The model has been applied successfully to the rf control simulation of the SC proton linac.

  2. SC tuning fork

    CERN Multimedia

    The tuning fork used to modulate the radiofrequency system of the synchro cyclotron (SC) from 1957 to 1973. This piece is an unused spare part. The SC was the 1st accelerator built at CERN. It operated from August 1957 until it was closed down at the end of 1990. In the SC the magnetic field did not change with time, and the particles were accelerated in successive pulses by a radiofrequency voltage of some 20kV which varied in frequency as they spiraled outwards towards the extraction radius. The frequency varied from 30MHz to about 17Mz in each pulse. The tuning fork vibrated at 55MHz in vacuum in an enclosure which formed a variable capacitor in the tuning circuit of the RF system, allowing the RF to vary over the appropriate range to accelerate protons from the centre of the macine up to 600Mev at extraction radius. In operation the tips of the tuning fork blade had an amplitude of movement of over 1 cm. The SC accelerator underwent extensive improvements from 1973 to 1975, including the installation of a...

  3. Monitor of SC beam profiles

    CERN Multimedia

    1977-01-01

    A high-resolution secondary emission grid for the measurement of SC beam profiles. Modern techniques of metal-ceramic bonding, developed for micro-electronics, have been used in its construction. (See Annual Report 1977 p. 105 Fig. 12.)

  4. First coil for the SC

    CERN Multimedia

    CERN PhotoLab

    1955-01-01

    The coils for the SC magnet were stored in the large hangar of the Cointrin Airport (to make sure that they would be available before snow and ice would block the roads and canals from Belgium, where they were built).

  5. 46 CFR 7.70 - Folly Island, SC to Hilton Head Island, SC.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Folly Island, SC to Hilton Head Island, SC. 7.70 Section... BOUNDARY LINES Atlantic Coast § 7.70 Folly Island, SC to Hilton Head Island, SC. (a) A line drawn from the southernmost extremity of Folly Island to latitude 32°35′ N. longitude 79°58.2′ W. (Stono Inlet Lighted...

  6. rotor of the SC rotating condenser

    CERN Multimedia

    1974-01-01

    The rotor of the rotating condenser was installed instead of the tuning fork as the modulating element of the radiofrequency system, when the SC accelerator underwent extensive improvements between 1973 to 1975 (see object AC-025). The SC was the first accelerator built at CERN. It operated from August 1957 until it was closed down at the end of 1990.

  7. Academic Training - Pulsed SC Magnets

    CERN Multimedia

    Françoise Benz

    2006-01-01

    2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 2, 3, June 29, 30, 31 May, 1, 2 June 11:00-12:00 - Auditorium, bldg 500 Pulsed SC Magnets by M. Wilson Lecture 1. Introduction to Superconducting Materials Type 1,2 and high temperature superconductors; their critical temperature, field & current density. Persistent screening currents and the critical state model. Lecture 2. Magnetization and AC Loss How screening currents cause irreversible magnetization and hysteresis loops. Field errors caused by screening currents. Flux jumping. The general formulation of ac loss in terms of magnetization. AC losses caused by screening currents. Lecture 3. Twisted Wires and Cables Filamentary composite wires and the losses caused by coupling currents between filaments, the need for twisting. Why we need cables and how the coupling currents in cables contribute more ac loss. Field errors caused by coupling currents. Lecture 4. AC Losses in Magnets, Cooling and Measurement Summary of all loss mech...

  8. Cs3ScCl6

    Directory of Open Access Journals (Sweden)

    Matthew D. Ward

    2014-06-01

    Full Text Available Crystals of tricaesium scandium(III hexachloride were obtained as a side product from the reaction of U, SnCl2, Sc, and S in a CsCl flux at 1073 K. Cs3ScCl6 crystallizes in the Rb3YCl6 structure type. The asymmetric unit comprises three Cs sites, two Sc sites, and six Cl sites, all of which have site symmetry 1, except for the two Sc sites that have site symmetries of 2 and -1, respectively. The structure is composed of isolated [ScCl6]3− octahedra that are surrounded by Cs+ cations. Two Cs+ cations have interactions with eight Cl− anions, while the third has interactions with ten Cl− anions.

  9. SC-FDMA for mobile communications

    CERN Document Server

    Abd El-Samie, Fathi E

    2013-01-01

    SC-FDMA for Mobile Communications examines Single-Carrier Frequency Division Multiple Access (SC-FDMA). Explaining this rapidly evolving system for mobile communications, it describes its advantages and limitations and outlines possible solutions for addressing its current limitations. The book explores the emerging trend of cooperative communication with SC-FDMA and how it can improve the physical layer security. It considers the design of distributed coding schemes and protocols for wireless relay networks where users cooperate to send their data to the destination. Supplying you with the re

  10. z206sc_video_observations

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents video observations from cruise Z206SC for the Santa Barbara Channel region and beyond in southern California. The vector data file is...

  11. z107sc_video_observations

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents video observations from cruise Z107SC for the Santa Barbara Channel region and beyond in southern California. The vector data file is...

  12. Bandwidth challenge teams at SC2003 conference

    CERN Multimedia

    2003-01-01

    Results from the fourth annual High-Performance Bandwidth Challenge, held in conjunction with SC2003, the international conference on high-performance computing and networking which occurred last week in Phoenix, AZ (1 page).

  13. Sc3N and Sc2C2 encapsulated B40: Smarter than its carbon analogue

    Science.gov (United States)

    Shah, Esha V.; Roy, Debesh R.

    2016-10-01

    A detailed comparative investigation on the recently synthesised B40 and C40 along with their metal nitride (Sc3N)and carbide (Sc2C2) encapsulated endohedral fullerenes, is performed under density functional theory for the first time. The structures, electronic, thermodynamic and magnetic properties of all the considered compounds are explored in detail. The present study identifies borospherene (B40) and its encapsulated nitride (Sc3N@B40) and carbide (Sc2C2@B40) endohedral borofullerenes as the better candidates for future novel nano-applications compared to their carbon bucky ball analogues.

  14. Recrystallization and Morphology of Microstructure in Al-Sc Alloys

    Institute of Scientific and Technical Information of China (English)

    Zhang Jun; Zhang Zonghua

    2007-01-01

    Minor addition of Sc to aluminum results in the rapid precipitation of homogeneously distributed Al3Sc dispersoids. The presence of Al3Sc dispersoids is more effective recrystallization inhibitors. Our work established the precipitation of homogeneously distributed Al3Sc dispersoids, which are coherent with the matrix, have the L12 structure. It was also established that the addition of Sc was effective in improving the recrystallization resistance.

  15. Sc20C60: a volleyballene

    Science.gov (United States)

    Wang, Jing; Ma, Hong-Man; Liu, Ying

    2016-06-01

    An exceptionally stable hollow cage containing 20 scandium atoms and 60 carbon atoms has been identified. This Sc20C60 molecular cluster has a Th point group symmetry and a volleyball-like shape that we refer to below as ``Volleyballene''. Electronic structure analysis shows that the formation of delocalized π bonds between Sc atoms and the neighboring pentagonal rings made of carbon atoms is crucial for stabilizing the cage structure. A relatively large HOMO-LUMO gap (~1.4 eV) was found. The results of vibrational frequency analysis and molecular dynamics simulations both demonstrate that this Volleyballene molecule is exceptionally stable.An exceptionally stable hollow cage containing 20 scandium atoms and 60 carbon atoms has been identified. This Sc20C60 molecular cluster has a Th point group symmetry and a volleyball-like shape that we refer to below as ``Volleyballene''. Electronic structure analysis shows that the formation of delocalized π bonds between Sc atoms and the neighboring pentagonal rings made of carbon atoms is crucial for stabilizing the cage structure. A relatively large HOMO-LUMO gap (~1.4 eV) was found. The results of vibrational frequency analysis and molecular dynamics simulations both demonstrate that this Volleyballene molecule is exceptionally stable. Electronic supplementary information (ESI) available: Sc20C60: a Volleyballene_SI. See DOI: 10.1039/c5nr07784b

  16. Norma Audio Revo SC-/PA-150

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Norma audio是意大利一间顶级HI-Fi音响器材生产商。这款IRevo SC-2/PA-150为正是公司旗下的一款高端型号产品。其中,Revo SC-2前置放大器的放大电路以低噪音、高速和宽频作为设计重点,能反映出音频信号中的每一个细节。

  17. Sc20C60: a volleyballene.

    Science.gov (United States)

    Wang, Jing; Ma, Hong-Man; Liu, Ying

    2016-06-01

    An exceptionally stable hollow cage containing 20 scandium atoms and 60 carbon atoms has been identified. This Sc20C60 molecular cluster has a Th point group symmetry and a volleyball-like shape that we refer to below as "Volleyballene". Electronic structure analysis shows that the formation of delocalized π bonds between Sc atoms and the neighboring pentagonal rings made of carbon atoms is crucial for stabilizing the cage structure. A relatively large HOMO-LUMO gap (∼1.4 eV) was found. The results of vibrational frequency analysis and molecular dynamics simulations both demonstrate that this Volleyballene molecule is exceptionally stable. PMID:26878201

  18. K2SC: K2 Systematics Correction

    Science.gov (United States)

    Aigrain, Suzanne; Parviainen, Hannu; Pope, Benjamin

    2016-05-01

    K2SC (K2 Systematics Correction) models instrumental systematics and astrophysical variability in light curves from the K2 mission. It enables the user to remove both position-dependent systematics and time-dependent variability (e.g., for transit searches) or to remove systematics while preserving variability (for variability studies). K2SC automatically computes estimates of the period, amplitude and evolution timescale of the variability for periodic variables and can be run on ASCII and FITS light curve files. Written in Python, this pipeline requires NumPy, SciPy, MPI4Py, Astropy (ascl:1304.002), and George (ascl:1511.015).

  19. CORRELATION BETWEEN SEED TESTS AND FIELD EMERGENCE OF TWO MAIZE HYBRIDS (SC704 AND SC500

    Directory of Open Access Journals (Sweden)

    A.A. ALILOO

    2011-11-01

    Full Text Available Early emergence and stand establishment of maize (Zea mays L. are considered to be the most important yield-contributing factors. The influence of seed vigor on these factors is vital. Therefore, five laboratory tests and field experiment were conducted on basis of a randomized complete block design (RCBD with five replications in 2011, to evaluate the correlation among the seed vigor tests and field emergence of two maize hybrids (SC704 and SC500. In laboratory tests, differences between two hybrids for cold test and electrical conductivity test were significant (P≤0.01. The leachates of hybrid SC500 was 35% higher than the leachates of hybrid SC704. However, high germination percentage was obtained by hybrid SC740 in cold test. A Statistically significant difference was found between hybrids in field emergence percentage (P≤0.05. The field emergence of hybrid SC704 and hybrid SC500 was 71% and 37%, respectively. The farm emergence percentage had the significant negative correlation (-0.71 with conductivity test, but positive correlation (0.79 with cold test. No significant correlation between the standard seed germination and the field emergence was detected. Therefore, the standard germination test was not a good indicator for field emergence percentage. However, cold and conductivity tests were the best predictor of field emergence than all the other laboratory tests.

  20. The Synchrocyclotron (SC) in building 300

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    The red magnet of CERN's first accelerator, the Synchrocyclotron (SC), has occupied a large part of Hall 300 since it was installed in the late 1950s. The remaining part of the 300-square-metre building has been used as a storage room since the accelerator was shut down in 1990. Now a public exhibition will breathe new life into the hall.

  1. New tumor-associated antigen SC6 in pancreatic cancer

    OpenAIRE

    Liu, Min-Pei; Guo, Xiao-Zhong; Xu, Jian-Hua; Wang, Di; Li, Hong-Yu; Cui, Zhong-Min; Zhao, Jia-Jun; Ren, Li-Nan

    2005-01-01

    AIM: To examine the concentration of a new antigen SC6 (SC6-Ag) recognized by monoclonal antibody (MAb) in patients with pancreatic cancer and other malignant or benign diseases and to understand whether SC6-Ag has any clinical significance in distinguishing pancreatic cancer from other gastrointestinal diseases.

  2. LHCb Data Replication During SC3

    CERN Multimedia

    Smith, A

    2006-01-01

    LHCb's participation in LCG's Service Challenge 3 involves testing the bulk data transfer infrastructure developed to allow high bandwidth distribution of data across the grid in accordance with the computing model. To enable reliable bulk replication of data, LHCb's DIRAC system has been integrated with gLite's File Transfer Service middleware component to make use of dedicated network links between LHCb computing centres. DIRAC's Data Management tools previously allowed the replication, registration and deletion of files on the grid. For SC3 supplementary functionality has been added to allow bulk replication of data (using FTS) and efficient mass registration to the LFC replica catalog.Provisional performance results have shown that the system developed can meet the expected data replication rate required by the computing model in 2007. This paper details the experience and results of integration and utilisation of DIRAC with the SC3 transfer machinery.

  3. The SC gets ready for visitors

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    Hall 300, which houses the Synchrocyclotron (SC), CERN’s first accelerator, is getting ready to host a brand-new exhibition. The site will be one of the stops on the new visit itineraries that will be inaugurated for the 2013 CERN Open Day.   The Synchrocyclotron through the years. Just as it did in the late 1950s, when the accelerator was first installed, the gigantic red structure of the Synchrocyclotron's magnet occupies a large part of the 300-square-metre hall. “We have completed the first phase of the project that will give the SC a new lease of life,” says Marco Silari, the project leader and a member of CERN’s Radiation Protection Group. “We have removed all the equipment that was not an integral part of the accelerator. The hall is now ready for the civil-engineering work that will precede the installation of the exhibition.” The SC was witness to a big part of the history of CERN. The accelerator produced ...

  4. Contraceptive efficacy and safety of DMPA-SC.

    Science.gov (United States)

    Jain, J; Jakimiuk, A J; Bode, F R; Ross, D; Kaunitz, A M

    2004-10-01

    DMPA-SC 104 mg/0.65 mL is a new, low-dose subcutaneous (SC) formulation of Depo-Provera contraceptive injection (150 mg/mL medroxyprogesterone acetate injectable suspension) that provides efficacy, safety and immediacy of onset equivalent to Depo-Provera intramuscular (IM) injection. Two large, open-label, Phase 3 studies assessed the 1-year contraceptive efficacy, safety and patient satisfaction with DMPA-SC administered every 3 months (12-13 weeks). Zero pregnancies were reported in both studies, which included a total of 16,023 woman-cycles of exposure to DMPA-SC and substantial numbers of overweight or obese women. DMPA-SC was well-tolerated and adverse events were similar to those reported previously with Depo-Provera IM. Thus, DMPA-SC offers women a new, highly effective and convenient long-acting contraceptive option. PMID:15451329

  5. SC response characteristics of two kinds of coagulant

    Institute of Scientific and Technical Information of China (English)

    杨万东; 宋爽; 史惠祥

    2002-01-01

    Automatic coagulant dosage control with streaming current (SC) technique is in troduced inthis paper. Aluminum and ferric coagulants are widely used in surface water treatment. The SC response characteristics of P-AiCI3 aluminum coagulant and P-FeCI3 ferric coagulant were investigated in this work. Bench-scale water treatment results were obtained from jar tests including rapid mixing,flocculation and undisturbed sedimentation. Results showed that aluminum coagulant is more sensitive than ferric coagulant to SC response.

  6. SC response characteristics of two kinds of coagulant

    Institute of Scientific and Technical Information of China (English)

    杨万东; 宋爽; 史惠祥

    2002-01-01

    Automatic coagulant dosage control with streaming current (SC) technique is introduced in this paper. Aluminum and ferric coagulants are widely used in surface water treatment. The SC response characteristics of P-AlCl3 aluminum coagulant and P-FeCl3 ferric coagulant were investigated in this work. Bench-scale water treatment results were obtained from jar tests including rapid mixing, flocculation and undisturbed sedimentation. Results showed that aluminum coagulant is more sensitive than ferric coagulant to SC response.

  7. Sc-47 production from titanium targets using electron linacs

    International Nuclear Information System (INIS)

    In this work we have studied the feasibility of photonuclear production of 47Sc from 48Ti via 48Ti(γ,p)47Sc reaction. Photon flux distribution for electron beams of different energies incident on tungsten converter was calculated using MCNPX radiation transport code. 47Sc production rate dependence on electron beam energy was found and 47Sc yields were estimated. It was shown that irradiating a natural Ti target results in numerous scandium isotopes which can reduce the specific activity of 47Sc. Irradiating enriched 48Ti targets with a 22 MeV 1 mA beam will result in hundreds of MBq/g activity of 47Sc and no other isotopes of scandium. Decreasing the size of the target will result in much higher average photon flux through the target and tens of GBq/g levels of specific activity of 47Sc. Increasing the beam energy will also result in higher yields, but as soon as the electron energy exceeds the 48Ti(γ,np)46Sc reaction threshold, 46Sc starts being produced and its fraction in total scandium atoms grows as beam energy increases. The results of the simulations were benchmarked by irradiating natural titanium foil with 22 MeV electron beam incident on the tungsten converter. Measured 47Sc activities were found to be in very good agreement with the predictions. - Highlights: • Optimum irradiation conditions of titanium targets were found. • MCNPX simulation and experimental results of Sc-47 yield are presented. • We demonstrated the feasibility of photonuclear production of Sc-47 from Ti-48

  8. Cyclotron production of {sup 44}Sc for clinical application

    Energy Technology Data Exchange (ETDEWEB)

    Krajewski, S.; Bilewicz, A. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cydzik, I. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection; Warsaw Univ. (Poland). Heavy Ion Lab.; Abbas, K. [European Commission Joint Research Center, Ispra (Italy). Institute for Transuranium Elements; Bulgheroni, A.; Simonelli, F.; Holzwarth, U. [European Commission Joint Research Center, Ispra (Italy). Inst. for Health and Consumer Protection

    2013-08-01

    {sup 44} is a promising {beta}{sup +}-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc{sup 3+} to the Lu{sup 3+} and Y{sup 3+} cations, {sup 44}Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the {sup 177}Lu- and {sup 90}Y-bioconjugates, what is important in planning the radionuclide therapy. {sup 44}Sc can be obtained from the {sup 44}Ti/{sup 44}Sc generator. An alternative method for {sup 44}Sc production can be the irradiation of {sup 44}Ca target at small cyclotrons. The aim of our work was to optimize the parameters of {sup 44}CaCO{sub 3} irradiation and to develop a simple procedure for {sup 44}Sc separation from the calcium target. For optimization study, {sup 44}CaCO{sub 3} targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for {sup 44}Ca irradiations. A simple and fast separation procedure of {sup 44}Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced {sup 44}Sc. While {sup 44}CaCO{sub 3} is relatively expensive, the cost of {sup 44}Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of {sup 44}Sc, the availability of {sup 44}Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging. (orig.)

  9. Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease.

    Science.gov (United States)

    Wanek, Justin; Gaynes, Bruce; Lim, Jennifer I; Molokie, Robert; Shahidi, Mahnaz

    2013-08-01

    The known biophysical variations of hemoglobin (Hb) S and Hb C may result in hemodynamic differences between subjects with SS and SC disease. The purpose of this study was to measure and compare conjunctival hemodynamics between subjects with Hb SS and SC hemoglobinopathies. Image sequences of the conjunctival microcirculation were acquired in 9 healthy control subjects (Hb AA), 24 subjects with SC disease, and 18 subjects with SS disease, using a prototype imaging system. Diameter (D) and blood velocity (V) measurements were obtained in multiple venules of each subject. Data were categorized according to venule caliber by averaging V and D for venules with diameters less than (vessel size 1) or greater than (vessel size 2) 15 µm. V in vessel size 2 was significantly greater than V in vessel size 1 in the AA and SS groups (P ≥ 0.009), but not in the SC group (P = 0.1). V was significantly lower in the SC group as compared to the SS group (P = 0.03). In AA and SS groups, V correlated with D (P ≤ 0.005), but the correlation was not statistically significant in the SC group (P = 0.08). V was inversely correlated with hematocrit in the SS group for large vessels (P = 0.03); however, no significant correlation was found in the SC group (P ≥ 0.2). Quantitative assessment of conjunctival microvascular hemodynamics in SS and SC disease may advance understanding of sickle cell disease pathophysiology and thereby improve therapeutic interventions.

  10. 76 FR 58401 - Safety Zone; Swim Around Charleston, Charleston, SC

    Science.gov (United States)

    2011-09-21

    ... Zone; Swim Around Charleston, Charleston, SC in the Federal Register (76 FR 38586). We received no... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Swim Around Charleston, Charleston, SC... temporary moving safety zone during the Swim Around Charleston, a swimming race occurring on waters of...

  11. Sc III Spectral Properties of Astrophysical Interest

    CERN Document Server

    Nandy, D K; Sahoo, B K; Li, Chengbin

    2011-01-01

    Transition properties such as oscillator strengths, transition rates, branching ratios and lifetimes of many low-lying states in the doubly ionized scandium (Sc III) are reported. A relativistic method in the coupled-cluster framework has been employed to incorporate the electron correlations due to the Coulomb interaction to all orders by considering all possible singly and doubly excited electronic configurations conjointly with the contributions from the leading order triple excitations in a perturbative approach. Present results are compared with the previously available results for the transition lines of astrophysical interest and the role of the correlation effects are also discussed concisely. Some of the transition rates, oscillator strengths and lifetimes are acquainted.

  12. SC2: Secure Communication over Smart Cards

    DEFF Research Database (Denmark)

    Dragoni, Nicola; Lostal, Eduardo; Papini, Davide;

    2012-01-01

    The Security-by-Contract (S×C) framework has recently been proposed to support software evolution in open multi-application smart cards. The key idea lies in the notion of contract, a specification of the security behavior of an application that must be compliant with the security policy...... of the card hosting the application. In this paper we address a key issue to realize the S×C idea, namely the outsourcing of the contractpolicy matching service to a Trusted Third Party (TTP). In particular, we present the design and implementation of (SC)2 (Secure Communication over Smart Cards), a system...... securing the communication between a smart card and the TTP which provides the S×C matching service....

  13. Thermal stability of Al-Mg-Sc-Zr alloy

    Institute of Scientific and Technical Information of China (English)

    ZHAO Wei-tao; YAN De-sheng; RONG Li-jian

    2006-01-01

    The thermal stability of Al3(Sc,Zr) precipitates in the cold worked Al-Mg-Sc-Zr alloy after elevated temperature exposure was investigated. The evaluation was conducted using room temperature tensile, Vicker's hardness, optical metallography and scanning electron microscope (SEM) with the backscatter. The results show that the Al3(Sc,Zr) precipitates and mechanical properties have no obvious change, and the grains keep elongated along the working direction as that in cold worked sample after exposure at 300 ℃ for 1 000 h. The coarsening of Al3(Sc,Zr) precipitates occurs and is no longer effective on the recrystallization resistance, and partial recrystallization is observed after 400 ℃ exposure. In particular, after 500 ℃ exposure, the hardness decreases drastically and the alloy has fully recrystallized due to the obvious coarsening of Al3(Sc,Zr) precipitates.

  14. Cyclotron production of 44Sc: From bench to bedside

    International Nuclear Information System (INIS)

    Introduction: 44Sc, a PET radionuclide, has promising decay characteristics (T1/2 = 3.97 h, Eβ+av = 632 keV) for nuclear imaging and is an attractive alternative to the short-lived 68Ga (T1/2 = 68 min, Eβ+av = 830 keV). The aim of this study was the optimization of the 44Sc production process at an accelerator, allowing its use for preclinical and clinical PET imaging. Methods: 44CaCO3 targets were prepared and irradiated with protons (~ 11 MeV) at a beam current of 50 μA for 90 min. 44Sc was separated from its target material using DGA extraction resin and concentrated using SCX cation exchange resin. Radiolabeling experiments at activities up to 500 MBq and stability tests were performed with DOTANOC by investigating different scavengers, including gentisic acid. Dynamic PET of an AR42J tumor-bearing mouse was performed after injection of 44Sc-DOTANOC. Results: The optimized chemical separation method yielded up to 2 GBq 44Sc of high radionuclidic purity. In the presence of gentisic acid, radiolabeling of 44Sc with DOTANOC was achieved with a radiochemical yield of ~ 99% at high specific activity (10 MBq/nmol) and quantities which would allow clinical application. The dynamic PET images visualized increasing uptake of 44Sc-DOTANOC into AR42J tumors and excretion of radioactivity through the kidneys of the investigated mouse. Conclusions: The concept “from-bench-to-bedside” was clearly demonstrated in this extended study using cyclotron-produced 44Sc. Sufficiently high activities of 44Sc of excellent radionuclidic purity are obtainable for clinical application, by irradiation of enriched calcium at a cyclotron. This work demonstrates a promising basis for introducing 44Sc to clinical routine of nuclear imaging using PET

  15. Fermi surface study of ScAu{sub 2}(Al, In) and ScPd{sub 2}(Sn, Pb) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, P. V. Sreenivasa; Kanchana, V., E-mail: kanchana@iith.ac.in [Department of Physics, Indian Institute of Technology Hyderabad, Ordnance Factory Estate, Yeddumailaram-502205, Telangana (India); Vaitheeswaran, G. [Advanced Centre of Research in High Energy Materials (ACRHEM), University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Hyderabad-500046 (India)

    2015-06-24

    A detailed study on the electronic structure and Fermi surface (FS) of superconducting Heusler compounds ScAu{sub 2}(Al, In) and ScPd{sub 2}(Sn, Pb) has been carried out using first principles electronic structure calculations. The spin orbit coupling is found to play a major role in understanding the band structure and FS. Analysis of the data shows the importance of spin orbit coupling effect in the above compounds. The bands which cross Fermi level (EF) are found to be dominated by the Sc d{sub t2g}-states. The calculated total density of states are in good agreement with the experimentally reported value for ScPd{sub 2}Sn. Under compression we find a change in the Fermi surface topology of ScPd{sub 2}Sn at V/V{sub 0} = 0.95 (pressure of≈15 GPa), which is explained using the band structure calculations.

  16. Fermi surface study of ScAu2(Al, In) and ScPd2(Sn, Pb) compounds

    International Nuclear Information System (INIS)

    A detailed study on the electronic structure and Fermi surface (FS) of superconducting Heusler compounds ScAu2(Al, In) and ScPd2(Sn, Pb) has been carried out using first principles electronic structure calculations. The spin orbit coupling is found to play a major role in understanding the band structure and FS. Analysis of the data shows the importance of spin orbit coupling effect in the above compounds. The bands which cross Fermi level (EF) are found to be dominated by the Sc dt2g-states. The calculated total density of states are in good agreement with the experimentally reported value for ScPd2Sn. Under compression we find a change in the Fermi surface topology of ScPd2Sn at V/V0 = 0.95 (pressure of≈15 GPa), which is explained using the band structure calculations

  17. Effects of cooling rate on solidification behavior of dilute Al-Sc and Al-Sc-Zr solid solution

    Institute of Scientific and Technical Information of China (English)

    金头男; 聂祚仁; 徐国富; 阮海琼; 杨军军; 付静波; 左铁镛

    2004-01-01

    Six alloys with different compositions of Al-0.1%Sc, Al-0.3%Sc, Al-0.3%Zr, Al-0.1% Sc-0. 1%Zr,Al-0.3%Sc-0.1%Zr and Al-0.3%Sc-0.3%Zr were prepared by casting in a wedge shaped copper mould. The hardness test, microstructure observation, and DSC thermal analysis were applied to fully investigate the solidification behavior of the wedge tip (whose cooling rate is 1 000 K/s) and the top surface (cooling rate 100 K/s) of each casting. The results show that the cast structures in the hypoeutectic region of Al-Sc alloys are slightly affected by cooling rates during the solidification. In the case of hypereutectic alloy of Al-0.3%Sc-0.3%Zr , the cast grains were remarkably refined under the condition of a 100 K/s cooling rate, however, under a 1 000 K/s cooling rate condition,solute atoms contribute nothing to the grain-refinement, due to the eutectic concentration becomes higher. The hardness can be improved to a greater degree by Sc single addition, compared to single Zr addition, but it can be improved even greater when Sc added together with Zr. It is sensitive to cooling rate, the higher the cooling rate, the greater the hardness. By combining the results of TEM examination and DSC analysis, it can be seen that a supersaturated Al solid solution forms during the solidification, and the solubility of Sc in Al solution can be improved by increasing the cooling rate.

  18. New tumor-associated antigen SC6 in pancreatic cancer

    Institute of Scientific and Technical Information of China (English)

    Min-Pei Liu; Xiao-Zhong Guo; Jian-Hua Xu; Di Wang; Hong-Yu Li; Zhong-Min Cui; Jia-Jun Zhao; Li-Nan Ren

    2005-01-01

    AIM: To examine the concentration of a new antigen SC6 (SC6-Ag) recognized by monoclonal antibody (MAb)in patients with pancreatic cancer and other malignant or benign diseases and to understand whether SC6-Ag has any clinical significance in distinguishing pancreatic cancer from other gastrointestinal diseases.METHODS: Six hundred and ninety-five serum specimens obtained from 115 patients with pancreatic cancer, 154 patients with digestive cancer and 95patients with non-digestive cancer were used and classified in this study. Serum specimens obtained from 140 patients with benign digestive disease and 89 patients with non-benign digestive disease served as controls. Ascites was tapped from 16 pancreatic cancer patients, 19 hepatic cancer patients, 16 colonic cancer patients, 10 gastric cancer and 6 severe necrotic pancreatitis patients. The samples were quantitated by solid-phase radioimmunoassay. The cut-off values (CV)of 41, 80, and 118 U/mL were used.RESULTS: The average intra- and interassay CV detected by immunoradiometric assay of SC6-Ag was 5.4% and 8.7%, respectively. The sensitivity and specificity were 73.0% and 90.9% respectively. The levels in most malignant and benign cases were within the normal upper limit. Among the 16 pancreatic cancer cases, the concentration of SC6-Ag in ascites was over the normal range in 93.8% patients. There was no significant difference in the concentration of SC6-Ag.Decreased expression of SC6-Ag in sera was significantly related to tumor differentiation. The concentration of SC6-Ag was higher in patients before surgery than after surgery. The specificity of SC6-Ag and CA19-9 was significantly higher than that of ultrasound and computer tomography (CT) in pancreatic cancer patients. Higher positive predictive values were indicated in 92.3% SC6-Ag and 88.5% CA19-9, but lower in 73.8% ultrasound and 76.2% CT.CONCLUSION: The combined test of SC6-Ag and CA19-9 may improve the diagnostic rate of primary cancer. The detection of

  19. NMR investigation of intermetallic compound FeΛ2Sc

    International Nuclear Information System (INIS)

    Structure, macro- and microscopic magnetic properties of Fe12Sc intermetallides are studied. The structure of compounds has been determined roentgenographically using FeKsub(α) irradiation. NMR measurements have been carried out at 4.2 77 and 293 K and structure measurements - at 293 K. Fe2Sc samples magnetation, measured with the help of vibrational manometer in the 9 kOe field and in the temperature range from 293-1000 K, is equal to approximately 400 Gs (measurement accuracy approximately 3%). Curie temperature for Fe2Sc is determined according to the point of magnetization curve decay bend at high temperatures. Analysis of NMR spectra is carried out

  20. Pascal-SC a computer language for scientific computation

    CERN Document Server

    Bohlender, Gerd; von Gudenberg, Jürgen Wolff; Rheinboldt, Werner; Siewiorek, Daniel

    1987-01-01

    Perspectives in Computing, Vol. 17: Pascal-SC: A Computer Language for Scientific Computation focuses on the application of Pascal-SC, a programming language developed as an extension of standard Pascal, in scientific computation. The publication first elaborates on the introduction to Pascal-SC, a review of standard Pascal, and real floating-point arithmetic. Discussions focus on optimal scalar product, standard functions, real expressions, program structure, simple extensions, real floating-point arithmetic, vector and matrix arithmetic, and dynamic arrays. The text then examines functions a

  1. Gadolinium scandium germanide, Gd2Sc3Ge4

    Directory of Open Access Journals (Sweden)

    Sumohan Misra

    2009-04-01

    Full Text Available Gd2Sc3Ge4 adopts the orthorhombic Pu5Rh4-type structure. The crystal structure contains six sites in the asymmetric unit: two sites are statistically occupied by rare-earth atoms with Gd:Sc ratios of 0.967 (4:0.033 (4 and 0.031 (3:0.969 (3, one site (.m. symmetry is occupied by Sc atoms, and three distinct sites (two of which with .m. symmetry are occupied by Ge atoms. The rare-earth atoms form two-dimensional slabs with Ge atoms occupying the trigonal-prismatic voids.

  2. Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.

    Science.gov (United States)

    Miyazawa, Kohtaro; Okada, Hiroyuki; Masujin, Kentaro; Iwamaru, Yoshifumi; Yokoyama, Takashi

    2015-01-01

    Disease-related prion protein (PrP(Sc)), which is a structural isoform of the host-encoded cellular prion protein, is thought to be a causative agent of transmissible spongiform encephalopathies. However, the specific role of PrP(Sc) in prion pathogenesis and its relationship to infectivity remain controversial. A time-course study of prion-affected mice was conducted, which showed that the prion infectivity was not simply proportional to the amount of PrP(Sc) in the brain. Centrifugation (20,000 ×g) of the brain homogenate showed that most of the PrP(Sc) was precipitated into the pellet, and the supernatant contained only a slight amount of PrP(Sc). Interestingly, mice inoculated with the obtained supernatant showed incubation periods that were approximately 15 d longer than those of mice inoculated with the crude homogenate even though both inocula contained almost the same infectivity. Our results suggest that a small population of fine PrP(Sc) may be responsible for prion infectivity and that large, aggregated PrP(Sc) may contribute to determining prion disease duration.

  3. Precipitation in cold-rolled Al-Sc-Zr and Al-Mn-Sc-Zr alloys prepared by powder metallurgy

    KAUST Repository

    Vlach, Martin

    2013-12-01

    The effects of cold-rolling on thermal, mechanical and electrical properties, microstructure and recrystallization behaviour of the AlScZr and AlMnScZr alloys prepared by powder metallurgy were studied. The powder was produced by atomising in argon with 1% oxygen and then consolidated by hot extrusion at 350 C. The electrical resistometry and microhardness together with differential scanning calorimetry measurements were compared with microstructure development observed by transmission and scanning electron microscopy, X-ray diffraction and electron backscatter diffraction. Fine (sub)grain structure developed and fine coherent Al3Sc and/or Al3(Sc,Zr) particles precipitated during extrusion at 350 C in the alloys studied. Additional precipitation of the Al3Sc and/or Al3(Sc,Zr) particles and/or their coarsening was slightly facilitated by the previous cold rolling. The presence of Sc,Zr-containing particles has a significant antirecrystallization effect that prevents recrystallization at temperatures minimally up to 420 C. The precipitation of the Al6Mn- and/or Al 6(Mn,Fe) particles of a size ~ 1.0 μm at subgrain boundaries has also an essential antirecrystallization effect and totally suppresses recrystallization during 32 h long annealing at 550 C. The texture development of the alloys seems to be affected by high solid solution strengthening by Mn. The precipitation of the Mn-containing alloy is highly enhanced by a cold rolling. The apparent activation energy of the Al3Sc particles formation and/or coarsening and that of the Al6Mn and/or Al 6(Mn,Fe) particle precipitation in the powder and in the compacted alloys were determined. The cold deformation has no effect on the apparent activation energy values of the Al3Sc-phase and the Al 6Mn-phase precipitation. © 2013 Elsevier Inc.

  4. IEC SC15E: Report on liaison activities of CIGRÉ-SC15

    DEFF Research Database (Denmark)

    Henriksen, Mogens

    2000-01-01

    WG’s activities under CIGRÉ SC15:WG 15.01 - Fluid impregnated systems.WG 15.02 - Dielectric Liquids.WG 15.03 - Gas Insulation.WG 15.04 - Outdoor Insulation.WG 15.05 - Capacitors.WG 15.07 - Solid Insulating Materials for Rotating Machines.WG 15/33.08 - Insulation Monitoring and Life Estimation. WG...... 15.09 - Advanced Materials.WG 15.10 - Internal Insulation and Interfaces.WG 15.11 - Service-Aged Materials.WG 15.12 - DC Insulation/Space Charge Measurements....

  5. Design of SC walls and slabs for impulsive loading

    Energy Technology Data Exchange (ETDEWEB)

    Varma, Amit H. [Purdue Univ., West Lafayette, IN (United States)

    2015-11-11

    Reinforced concrete (RC) structures have historically been the preferred choice for blast resistant structures because of their mass and the ductility provided by steel reinforcement. Steel-plate composite (SC) walls are a viable alternative to RC for protecting the infrastructure against explosive threats. SC structures consist of two steel faceplates with a plain concrete core between them. The steel faceplates are anchored to the concrete using stud anchors and connected to each other using tie bars. SC structures provide mass from the concrete infill and ductility from the continuous external steel faceplates. This dissertation presents findings and recommendations from experimental and analytical investigations of the performance of SC walls subjected to far-field blast loads.

  6. scFv Antibody: Principles and Clinical Application

    Directory of Open Access Journals (Sweden)

    Zuhaida Asra Ahmad

    2012-01-01

    Full Text Available To date, generation of single-chain fragment variable (scFv has become an established technique used to produce a completely functional antigen-binding fragment in bacterial systems. The advances in antibody engineering have now facilitated a more efficient and generally applicable method to produce Fv fragments. Basically, scFv antibodies produced from phage display can be genetically fused to the marker proteins, such as fluorescent proteins or alkaline phosphatase. These bifunctional proteins having both antigen-binding capacity and marker activity can be obtained from transformed bacteria and used for one-step immunodetection of biological agents. Alternatively, antibody fragments could also be applied in the construction of immunotoxins, therapeutic gene delivery, and anticancer intrabodies for therapeutic purposes. This paper provides an overview of the current studies on the principle, generation, and application of scFv. The potential of scFv in breast cancer research is also discussed in this paper.

  7. Development of SC structure modularization in Nuclear Power Plant

    International Nuclear Information System (INIS)

    New Focus on NPP are Rising Concerns on Global Warming, Potential energy crisis (geo-political), Improved reliability and safety of nuclear power plant, Advent of Generation 3+ NPP technology and Economical Energy Resource. New NPPs are 6 units in Korea and 23 in Asia being built, 32 units being planned in China by 2020 (150 by 2050), 10 units being planned in US by 2020 and IAEA expects $200 billions on NPP construction next 25 years (up to 30% of total world energy). □ SC(Steel Plate Concrete) structure · Steel Plate is used as a Structural Element instead of Reinforcing Bars in RC · SC structure consists of Steel Plate with Headed Studs. Connected by Tie-bars - The Primary Purpose of Tie-bars is to Stiffen and Hold Together the Plates during Construction Process - Headed Studs are Welded to the Inside of Steel Plate for composite action □ Benefits of SC Structure · Shorten Construction Duration for Re bar, Forming and Scaffolding Works · Minimize Site Labors · Improve the Construction Quality · Enable Construction Sites to be kept Clean □ SC Modularization · Fit for Modular Construction for Structural Features · Fit for Modular Construction for Structural Features · Inattentively Effective for Integrated Modules · Pre-fabrication, Pre-assembly and Modularization □ Project Overview · Project Name: Development of SC structure for Modularization in NPP · Project Type: Electric Power Industry R and D (Ministry of Knowledge Economy) · Duration: Sep. 2005 ∼ Aug. 2008 (36 Months) · Research Team and Scopes - Project Management: Korea Hydro and Nuclear Power Company (KHNP) - Development of Code and Standards for SC Structure: Korea Society of Steel Construction (KSSC) Korea Electric Power Research Institute (KEPRI) - Development of SC Structural Analysis and Design: Korea Power Engineering Company (KOPEC) - Development of Construction Techniques for SC Modularization: KHNP, Korea Institute of Nuclear Safety(KINS), KOPEC □ Performance

  8. Electrochemical Characterization of Ni/(Sc)YSZ Electrodes

    DEFF Research Database (Denmark)

    Ramos, Tania; Thydén, Karl Tor Sune; Mogensen, Mogens Bjerg

    2010-01-01

    Investigations of Ni/(Sc)YSZ cermets for solid oxide cells (SOCs) were performed by electrochemical impedance spectroscopy (EIS), under varying experimental conditions and upon redox cycling, using three different designs of symmetric cells. The deconvolution and fitting of the obtained impedance...... parameters. Initial degradation results for both Ni/ScYSZ and Ni/YSZ based anodes under very high steam content are also reported. ©2010 COPYRIGHT ECS - The Electrochemical Society...

  9. Parametric Study of SC Panel Subjected to Impact Loading

    International Nuclear Information System (INIS)

    FE analysis with impact test for small scale structure is necessary, because it is impossible to perform full scale test for safety assessment of NPP structures. Analysis factors such as erosion value, strain rate effect, and material model of concrete and steel can influence the analysis results. In this paper, the effects of concrete fracture energy and erosion in material model on FE results of SC panel subjected to impact loading are evaluated using a commercial program LS-DYNA. The analysis results are compared with impact test for SC panel conducted by other researchers. Parametric studies were performed to evaluate the structural behavior of SC panels according to the fracture energy of concrete and erosion values of concrete and steel. Based on these studies, the following conclusions have been obtained : SC panel with an applied erosion value of ±7% for tension and compression of concrete agreed well with the test result. The erosion of steel had not influenced structural behavior, because the failure mode of SC panel is non-perforation mode. SC panel using the concrete fracture energy of 0.152N/mm corresponding to the maximum aggregate size of 32mm showed a good agreement with the test result

  10. Heteronuclear transition metal diatomics - The bonding and electronic structure of ScNi, YNi, ScPd, and YPd

    Science.gov (United States)

    Faegri, Knut, Jr.; Bauschlicher, Charles W., Jr.

    1991-01-01

    High quality ab initio calculations show that ScNi, YNi, ScPd, and YPd all have 2Sigma(+) ground states in agreement with electron spin resonance experiments. For ScNi and YNi, this is expected based on the lowest atomic asymptote. For ScPd and YPd, the lowest atomic asymptote would give the order of stability 2Delta greater than 2Pi equal to about 2Sigma(+), but the calculations show that mixing in of the excited asymptotes preferentially lowers the 2Sigma(+) state. The calculations show that the quartet states are about 20-30 kcal/mol above the ground state, and therefore probably do not contribute significantly to the unexpected g(vertical) values found in experiment. Calculations of excited states for YPd reveal some strong transitions that should be amenable to spectroscopic studies.

  11. Medialogy (English Information Brochure on the education M.Sc.,Medialogy, 3rd to 10th semester (B.Sc. & M.Sc) - For graduates from higher study programmes such as Multimedia Design and IT Graduates)

    DEFF Research Database (Denmark)

    Nordahl, Rolf

    2005-01-01

    An information brochure, 24 pages, in English which describes the education M.Sc., Medialogy, offered by Aalborg University in Copenhagen and Esbjerg. The brochure describes the 3rd to 10th semester (B.Sc. and M.Sc. degree) of the education. The information is primarily directed toward potential...

  12. Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

    OpenAIRE

    Huang, Emina H.; Hynes, Mark J.; Zhang, Tao; Ginestier, Christophe; Dontu, Gabriela; Appelman, Henry; Fields, Jeremy Z.; Wicha, Max S.; Boman, Bruce M

    2009-01-01

    Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identification and isolation of SC from normal and malignant colon. Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a possible marker for identifying colonic SC and for tra...

  13. Unexpected magnetic behavior in amorphous Co90Sc10 alloy

    International Nuclear Information System (INIS)

    An amorphous alloy Co90Sc10 has been prepared by rapid quenching from the melt. The results of magnetization measurements show that this alloy has the highest Curie temperature reported for any amorphous transition metal based alloys. Furthermore, for a Co based amorphous alloy, the magnetic moment is remarkably high. Moreover, the alloy exhibits soft magnetic properties. Based on the findings, amorphous Co90Sc10 appears to be an attractive candidate for applications as a soft magnetic material. The temperature dependence of the reduced magnetization can be described by the Bloch power law. The results show that the B coefficient of the amorphous Co90Sc10 alloy, which is a measure of the rigidity of spin waves, exhibits the lowest value observed until now for any amorphous alloy and is comparable to crystalline alloys. It is found that the Sc atoms in the Co90Sc10 alloy lead to an increase of the itinerant spin moment of Co atoms, and, in contrast to this behaviour, to a decrease of the local 3d-electrons of Co

  14. Unexpected magnetic behavior in amorphous Co90Sc10 alloy

    Science.gov (United States)

    Ghafari, M.; Sakurai, Y.; Peng, G.; Fang, Y. N.; Feng, T.; Hahn, H.; Gleiter, H.; Itou, M.; Kamali, S.

    2015-09-01

    An amorphous alloy Co90Sc10 has been prepared by rapid quenching from the melt. The results of magnetization measurements show that this alloy has the highest Curie temperature reported for any amorphous transition metal based alloys. Furthermore, for a Co based amorphous alloy, the magnetic moment is remarkably high. Moreover, the alloy exhibits soft magnetic properties. Based on the findings, amorphous Co90Sc10 appears to be an attractive candidate for applications as a soft magnetic material. The temperature dependence of the reduced magnetization can be described by the Bloch power law. The results show that the B coefficient of the amorphous Co90Sc10 alloy, which is a measure of the rigidity of spin waves, exhibits the lowest value observed until now for any amorphous alloy and is comparable to crystalline alloys. It is found that the Sc atoms in the Co90Sc10 alloy lead to an increase of the itinerant spin moment of Co atoms, and, in contrast to this behaviour, to a decrease of the local 3d-electrons of Co.

  15. Ab-initio studies of the Sc adsorption and the ScN thin film formation on the GaN(000-1)-(2 × 2) surface

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero-Sánchez, J., E-mail: guerrero@ifuap.buap.mx [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Sánchez-Ochoa, F.; Cocoletzi, Gregorio H.; Rivas-Silva, J.F. [Benemérita Universidad Autónoma de Puebla, Instituto de Física “Ing Luis Rivera Terrazas”, Apartado Postal J-48, Puebla 72570 (Mexico); Takeuchi, Noboru [Universidad Nacional Autónoma de México, Centro de Nanociencia y Nanotecnología, Apartado Postal 2681, Ensenada, Baja California 22800 (Mexico)

    2013-12-02

    First principles total energy calculations have been performed to investigate the initial stages of the Sc adsorption and ScN thin film formation on the GaN(000-1)-(2 × 2) surface. Studies are done within the periodic density functional theory as implemented in the PWscf code of the Quantum ESPRESSO package. The Sc adsorption at high symmetry sites results in the bridge site as the most stable structure. When a Sc monolayer is deposited above the surface the T4 site results as the most stable geometry. The Sc migration into the first Ga monolayer induces the Ga displaced ad-atom to be adsorbed at the T4-2 site. A ScN bilayer may be obtained under the Ga monolayer. Finally a ScN bilayer may be formed in the wurtzite phase above the surface. The formation energy plots show that in the moderate Ga-rich conditions we obtain the formation of a ScN bilayer under the gallium monolayer. However at N-rich conditions the formation of ScN bilayer above the surface is the most favorable structure. We report the density of states to explain the electronic structure of the most favorable geometries. - Highlights: • Studies of the initial stages in the formation of Sc and ScN structures on GaN • In the adsorption of Sc on the GaN the Br site is the most favorable geometry. • When a Sc replaces a Ga of the first monolayer the displaced Ga occupies a T4-2 site. • For Ga-rich conditions there is formation of ScN under the Ga monolayer. • In N-rich conditions there is formation of ScN in the wurtzite phase.

  16. Sex Chromosome Meiotic Drive Systems in DROSOPHILA MELANOGASTER I. Abnormal Spermatid Development in Males with a Heterochromatin-Deficient X Chromosome (sc4sc8)

    Science.gov (United States)

    Peacock, W. J.; Miklos, George L. Gabor; Goodchild, D. J.

    1975-01-01

    The meiotic drive characteristics of the In(1)sc4Lsc8R/Y system have been examined by genetic analysis and by light and electron microscopy. sc4sc8/Y males show a direct correlation between nondisjunction frequency and meiotic drive. Temperature-shift experiments reveal that the temperature-sensitive period for nondisjunction is at meiosis, whereas that for meiotic drive has both meiotic and post-meiotic components. Cytological analyses in the light and electron microscopes reveal failures in spermiogenesis in the testes of sc4sc8 males. The extent of abnormal spermatid development increases as nondisjunction becomes more extreme. PMID:805751

  17. Experience with OpenMP for MADX-SC

    Energy Technology Data Exchange (ETDEWEB)

    D' Imperio, Nicholas [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Montag, Christophe [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Yu, Kwangmin [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Kapin, Valery [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); McIntosh, Eric [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Renshall, Harry [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Schmidt, Frank [European Organization for Nuclear Research (CERN), Geneva (Switzerland)

    2014-07-01

    MADX-SC allows the treatment of frozen space charge using beam-beam elements in a thin lattice, i.e. one can take advantage of the standard set-up of MAD-X lattices without the need for specialized codes for the space-charge (SC) evaluation. The idea is to simulate over many turns without the problem of noise as in the PIC SC codes. For the examples under study, like the PS and RHIC, it would be desirable to simulate up to 1 million turns or more. To this end one had to make an effort to optimize the scalar speed and, most importantly, get a speed-up of approximately a factor of 5 using OpenMP.

  18. Experience with OpenMP 1 for MADX-SC

    CERN Document Server

    D’Imperio, N; Yu, K; Kapin, V; McIntosh, E; Renshall, H; Schmidt, F

    2014-01-01

    MADX-SC [1–3] allows the treatment of frozen space charge using beam-beam elements in a thin lattice, i.e. one can take advantage of the standard set-up of MAD-X [4] lattices without the need for specialized codes for the space-charge (SC) evaluation. The idea is to simulate over many turns without the problem of noise as in the PIC 1 SC codes. For the examples under study, like the PS and RHIC, it would be desirable to simulate up to 1 million turns or more. To this end one had to make an effort to optimize the scalar speed and, most importantly, get a speed-up of approximately a factor of 5 using OpenMP [5].

  19. Transport of one SC coil through the village of Meyrin

    CERN Multimedia

    1956-01-01

    In 1952, before CERN was officially founded, two accelerator projects were launched: one for an innovative accelerator to operate at an energy level unequalled at the time, the other for a more standard machine, a Synchro-Cyclotron (SC) to operate at 600 MeV. Design work on the SC was started in 1952 and carried out by teams scattered throughout Europe. Once construction began in 1954, CERN had to arrange road transport for the first of what has since been a long series of spectacular component deliveries, such as those of the machine's two magnetic coils each weighing 60 tonnes and measuring 7.2 metres in diameter. Above, one of them is seen passing through the village of Meyrin. The SC was commissioned in 1957 and was operational for 34 years!

  20. La scène punk montréalaise

    OpenAIRE

    Lussier, Martin

    2011-01-01

    Cet article est consacré à l’un des moments clés de la scène punk, le concert, et à ce qui se déroule à l’intérieur des murs des salles de spectacle la peuplant. Une attention toute particulière est portée à la façon dont les concerts installent le punk en tant que scène, avec ses lignes de fractures et ses forces métissantes. Le punk, installé en tant que scène, nous apparaît comme un lieu où se croisent à la fois des tendances à diviser des ensembles, à circonscrire certains mondes d’acteur...

  1. Determination of Sc by Ion-exchanger Colorimetry

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Ion-exchanger colorimetry for scandium in the form of ternary color system "Sc(Ⅲ)-CPA-pc-Ac" was developed. The influences of types and grain sizes of resin, adsorption modes and the acidity on the determination were studied systematically, and the optimum operating conditions and the allowable amounts of foreign ions were determined. In comparison with the ordinary solution colorimetry, both of the sensitivity and the selectivity of this ion-exchanger colorimetry are improved obviously. The preliminary uses of this method to the determination of Sc(Ⅲ) in two synthetic samples were satisfied.

  2. Thermoelectric performance of functionalized Sc 2 C MXenes

    KAUST Repository

    Kumar, S.

    2016-07-05

    Functionalization of the MXene Sc2C, which has the rare property to realize semiconducting states for various functionalizations including O, F, and OH, is studied with respect to the electronic and thermal behavior. The lowest lattice thermal conductivity is obtained for OH functionalization and an additional 30% decrease can be achieved by confining the phonon mean free path to 100 nm. Despite a relatively low Seebeck coefficient, Sc2C(OH)2 is a candidate for intermediate-temperature thermoelectric applications due to compensation by a high electrical conductivity and very low lattice thermal conductivity.

  3. Product policy of SC Electrecord S.A.

    Directory of Open Access Journals (Sweden)

    Ph. D. Candidate Cristina Andreescu (Manolache

    2009-12-01

    Full Text Available The global brand has the advantage of the scale economy, facilitates the company image and prestige and sometimes benefits even from its origin country effect. Its use is quite difficult (the semantic variations can impede the use of the same brand. The international brands act as a restriction against standardisation (the product should not be differentiated as there are internationally accepted and recognized brands. This paper makes an overview description of the general market environment, but also of the arket environment of SC ELECTRECORD S.A.; it underlines the product characteristics as well as the commercial diagnosis within SC ELECTRECORD S.A.

  4. Experimental Progress of DC-SC Photoinjector at Peking University

    CERN Document Server

    Wang, G M; Ding, Y T; Hao, J; Huang, S L; Lin, L; Lu, X Y; Quan, S W; Wang, L F; Xiang, R; Zhang, B C; Zhao, K; Jiao, F; Xie, D; Yang, L; Zhu, F; Liu, C; Wang, F; Xu, W; Liu, Z

    2005-01-01

    Beam loading experiments on DC-SC photoinjector test facility have been finished at 4.4 K. Upon the present experiments, the gradient of 6 MV/m is achieved. The maximum energy gain is 1.1 MeV at 4.4 K. With average beam current of 270 mA, the measured rms emittance is about 5 mm-mrad at the beam energy of 500 keV. Experiments on the test facility has validated that the DC-SC photoinjector is a good choice to provide moderate average current electron beams with low bunch charge and very high repetition rate.

  5. Radiation protection Group (SC/RP) desperately seeking...

    CERN Multimedia

    A. Hervé, Y. Donjoux / SC

    2006-01-01

    We are trying to trace two transit permits (passavants), which constitute the customs clearance documentation for two 'AD6'portable radiation detectors. The two permits (No. 1308 and No. 1309) were sent in the same internal mail envelope towards the middle of March 2006 but never reached their final destination. After weeks of searching in vain, we are now appealing for your help. If you have these two permits in your possession, please get in touch with us. Many thanks in advance. A.HERVE - SC/RP- ( 163168 / 70927) Y.DONJOUX - SC/RP - (160105 / 73171)

  6. Tetrahedron dynamics in the icosahedral quasicrystals i-ZnMgSc and i-ZnAgSc and the cubic 1/1-approximant Zn6Sc.

    Science.gov (United States)

    Euchner, H; Yamada, T; Rols, S; Ishimasa, T; Kaneko, Y; Ollivier, J; Schober, H; Mihalkovic, M; de Boissieu, M

    2013-03-20

    A comparison of periodic approximants and their quasicrystalline counterparts offers the opportunity to better understand the structure, physical properties and stabilizing mechanisms of these complex phases. We present a combined experimental and molecular dynamics study of the lattice dynamics of the icosahedral quasicrystals i-ZnMgSc and i-ZnAgSc and compare it to recently published results obtained for the cubic 1/1-approximant Zn(6)Sc. Both phases, quasicrystal and approximant, are built up from large atomic clusters which contain a tetrahedral shell at the cluster centre and are packed either quasiperiodically or on a bcc lattice. Using quasielastic neutron scattering and atomic scale simulations, we show that in the quasicrystal the tetrahedra display a dynamics similar to that observed in the 1/1-approximant: the tetrahedra behave as a 'single molecule' and reorient dynamically on a timescale of the order of a few ps. The tetrahedra reorientation is accompanied by a large distortion of the surrounding cluster shells which provide a unique dynamical flexibility to the quasicrystal. However, whereas in the 1/1-approximant the tetrahedron reorientation is observed down to T(c) = 160 K, where a phase transition takes place, in the quasicrystal the tetrahedron dynamics is gradually freezing from 550 to 300 K, similarly to a glassy system.

  7. 44gSc from metal calcium targets for PET

    DEFF Research Database (Denmark)

    Severin, Gregory; Gagnon, K.; Engle, J. W.;

    2012-01-01

    A low-cost and efficient method for producing pre-clinical scale quantities of 44gSc is presented. Production involves proton irradiation of natural unenriched calcium metal followed by rapid separation of radioscandium from the target using hydroxmate functionalized resin.© 2012 American Institu...

  8. Calibration of the DLP-SC-3300-02 probe

    DEFF Research Database (Denmark)

    Pivnenko, Sergey; Breinbjerg, Olav

    This report douments the calibration measurement of the DLP-SC-3300-02 dual-linearly polarized near-field probe. The measurement comprises radiation pattern, diretivity, gain, spetra of spherial wave coefients, polarization charateristis, and complex channel balance at 41 frequencies, as well...

  9. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering....

  10. Scandium carbides/cyanides in the boron cage: computational prediction of X@B80 (X = Sc2C2, Sc3C2, Sc3CN and Sc3C2CN).

    Science.gov (United States)

    Jin, Peng; Liu, Chang; Hou, Qinghua; Li, Lanlan; Tang, Chengchun; Chen, Zhongfang

    2016-08-01

    As the first study on metal carbide/cyanide boron clusterfullerenes, the geometries, energies, stabilities and electronic properties of four novel scandium cluster-containing B80 buckyball derivatives, namely Sc2C2@B80, Sc3C2@B80, Sc3CN@B80 and Sc3C2CN@B80, were investigated by means of density functional theory computations. The rather favorable binding energies, which are very close to those of the experimentally abundant carbon fullerene analogues, suggest a considerable possibility to realize these doped boron clusterfullerenes. Their intracluster and cluster-cage bonding natures were thoroughly revealed by various theoretical approaches. In contrast to carbon clusterfullerenes, in which the encaged non-metal atoms mainly play a stabilizing role in the metal clusters, the encapsulated carbon and nitrogen atoms inside the B80 cage covalently bond to the boron framework, resulting in strong cluster-cage interactions. Furthermore, infrared spectra and (11)B nuclear magnetic resonance spectra were simulated and fingerprint peaks were proposed to assist future experimental characterization. PMID:27424658

  11. 78 FR 62001 - South Carolina Disaster #SC-00024

    Science.gov (United States)

    2013-10-10

    ... ADMINISTRATION South Carolina Disaster SC-00024 AGENCY: U.S. Small Business Administration. ACTION: Notice...: 07/07/2014. ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration... CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409 3rd Street...

  12. Toelating Herbasan SC welkom voor dahlia, A. coronaria en narcis

    NARCIS (Netherlands)

    Leeuwen, van P.J.; Koster, A.T.J.; Trompert, J.P.T.

    2005-01-01

    Onlangs is Herbasan SC voor de onkruidbestrijding in onder meer dahlia, narcis en Anemone coronaria toegelaten. PPO ging na hoe het middel het beste is in te zetten. In dit artikel zijn de resultaten van het onderzoek vermeld en een advies voor toepassing

  13. South Carolina's SC LENDS: Optimizing Libraries, Transforming Lending

    Science.gov (United States)

    Hamby, Rogan; McBride, Ray; Lundberg, Maria

    2011-01-01

    Since SC LENDS started operating in June 2009, more public libraries have come on board. All of this on the back end connects to a Mozilla-based staff client that has distributions for Mac OS X and Microsoft Windows, using SSL encryption to keep communications secure and private between remote libraries and the servers hosted at a high-end…

  14. 77 FR 14700 - Safety Zones; Swim Around Charleston, Charleston, SC

    Science.gov (United States)

    2012-03-13

    ... notice regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zones; Swim Around Charleston, Charleston, SC... establish temporary moving safety zones during the Swim Around Charleston, a swimming race occurring on...

  15. 76 FR 38586 - Safety Zone; Swim Around Charleston, Charleston, SC

    Science.gov (United States)

    2011-07-01

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Swim Around Charleston, Charleston, SC... establish a temporary moving safety zone during the Swim Around Charleston, a swimming race occurring...

  16. 78 FR 54583 - Safety Zone; Swim Around Charleston, Charleston, SC

    Science.gov (United States)

    2013-09-05

    ..., telephone 202-366-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Swim Around Charleston, Charleston, SC... temporary moving safety zone during the Swim Around Charleston, a swimming race occurring on waters of...

  17. 77 FR 51471 - Safety Zone; Swim Around Charleston, Charleston, SC

    Science.gov (United States)

    2012-08-24

    ... rulemaking (NPRM) entitled Safety Zone; Swim Around Charleston, Charleston, SC in the Federal Register (77 FR...: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Swim Around Charleston, Charleston,...

  18. 44gSc from metal calcium targets for PET

    DEFF Research Database (Denmark)

    Severin, Gregory; Gagnon, K.; Engle, J. W.;

    2012-01-01

    A low-cost and efficient method for producing pre-clinical scale quantities of 44gSc is presented. Production involves proton irradiation of natural unenriched calcium metal followed by rapid separation of radioscandium from the target using hydroxmate functionalized resin.© 2012 American Institute...

  19. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    This catalogue contains a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering....

  20. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    The catalogue contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...... projects at the M.Sc. programme in Civil and Structural Engineering....

  1. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    Clausen, Johan

    The report contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester...... projects at the M.Sc. programme in Civil and Structural Engineering....

  2. A Study on the Fluorescence System of Sc-BPMPHD-CTMAB and Its Analytical Application

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ Introduction The fluorescence of Sc3+ itself in solution is not observed. After complexed with an organic ligand with a chromophore, Sc3+ makes the ligand, which has no or has weak fluorescence, emit strong fluorescence.

  3. Preparation and characterization of Sc doped MgB2 wires

    DEFF Research Database (Denmark)

    Grivel, Jean-Claude; Burdusel, M.

    2016-01-01

    The in-situ technique was used to manufacture scandium (Sc) doped MgB2 wires in a composite Cu–Nb sheath. After reaction at 700 °C, at most 1 at.% Mg was replaced by Sc in the MgB2 phase, without significant influence on its superconducting transition temperature. For higher Sc concentrations...

  4. Crystal fields of dilute Tb, Dy, or Er in Sc obtained by magnetization measurements

    DEFF Research Database (Denmark)

    Høg, J.; Touborg, P.

    1976-01-01

    Crystal-field parameters for dilute Sc-Tb, Sc-Dy, and Sc-Er alloys have been obtained by fitting theoretical expressions to the experimentally measured paramagnetic susceptibility. The initial susceptibility was measured and corrected for the effects of ordering at the lowest temperatures in the ...

  5. File list: Unc.PSC.05.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1...074908,SRX1074905 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.EpiSC.bed ...

  6. File list: Unc.PSC.20.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1...074908,SRX1074905 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.EpiSC.bed ...

  7. File list: Unc.PSC.50.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1...074905,SRX1074908 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.EpiSC.bed ...

  8. Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae.

    Science.gov (United States)

    Gan, Zhen; Chen, Shannan; Hou, Jing; Huo, Huijun; Zhang, Xiaolin; Ruan, Baiye; Laghari, Zubair Ahmed; Li, Li; Lu, Yishan; Nie, Pin

    2016-07-01

    PGRP-SC2, the member of PGRP family, plays an important role in regulation of innate immune response. In this paper, a PGRP-SC2 gene of Nile tilapia, Oreochromis niloticus (designated as On-PGRP-SC2) was cloned and its expression pattern under the infection of Streptococcus agalactiae was investigated. Sequence analysis showed main structural features required for amidase activity were detected in the deduced amino acid sequence of On-PGRP-SC2. In healthy tilapia, the On-PGRP-SC2 transcripts could be detected in all the examined tissues, with the most abundant expression in the muscle. When infected with S. agalactiae, there was a clear time-dependent expression pattern of On-PGRP-SC2 in the spleen, head kidney and brain. The assays for the amidase activity suggested that recombinant On-PGRP-SC2 protein had a Zn(2+)-dependent PGN-degrading activity. Moreover, our works showed that recombinant On-PGRP-SC2 protein could significantly reduce bacterial load in target organs attacked by S. agalactiae. These findings indicated that On-PGRP-SC2 may play important roles in the immune response to S. agalactiae in Nile tilapia.

  9. Study of structural and electronic properties of ScN and ScAs in rocksalt and zincblende structure: A DFT approach

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, Vikas, E-mail: vikas.nayak88@gmail.com; Verma, U. P., E-mail: upv.udai@gmail.com [School of Studies in Physics, Jiwaji University, Gwalior-474011 (India)

    2015-08-28

    In this paper, we have studied the structural and electronic properties of ScN and ScAs in zincblende (ZB) and rocksalt (RS) phases. We have employed the full potential linearized augmented plane wave (FP-APW) method within the density functional theory (DFT). Generalized gradient approximation (GGA), due to Perdew-Burke-Ernzerhof (PBE) has been used to estimate the exchange-correlation functional. Our band structure results for ScN shows the metallic nature, whereas ScAs shows the semiconducting behavior. The obtained results are in excellent agreement with earlier reported data.

  10. Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae.

    Science.gov (United States)

    Gan, Zhen; Chen, Shannan; Hou, Jing; Huo, Huijun; Zhang, Xiaolin; Ruan, Baiye; Laghari, Zubair Ahmed; Li, Li; Lu, Yishan; Nie, Pin

    2016-07-01

    PGRP-SC2, the member of PGRP family, plays an important role in regulation of innate immune response. In this paper, a PGRP-SC2 gene of Nile tilapia, Oreochromis niloticus (designated as On-PGRP-SC2) was cloned and its expression pattern under the infection of Streptococcus agalactiae was investigated. Sequence analysis showed main structural features required for amidase activity were detected in the deduced amino acid sequence of On-PGRP-SC2. In healthy tilapia, the On-PGRP-SC2 transcripts could be detected in all the examined tissues, with the most abundant expression in the muscle. When infected with S. agalactiae, there was a clear time-dependent expression pattern of On-PGRP-SC2 in the spleen, head kidney and brain. The assays for the amidase activity suggested that recombinant On-PGRP-SC2 protein had a Zn(2+)-dependent PGN-degrading activity. Moreover, our works showed that recombinant On-PGRP-SC2 protein could significantly reduce bacterial load in target organs attacked by S. agalactiae. These findings indicated that On-PGRP-SC2 may play important roles in the immune response to S. agalactiae in Nile tilapia. PMID:27033804

  11. Structural, elastic and thermodynamic properties of Ti2SC

    Indian Academy of Sciences (India)

    Hongzhi Fu; Wenfang Liu; Tao Gao

    2011-12-01

    The structural parameters, elastic constants and thermodynamic properties of Ti2SC were investigated under pressure and temperature by using first-principles plane-wave pseudopotential density functional theory within the generalized gradient approximation. The obtained results are in agreement with the available experimental data. The bulk moduli along the - and -axes, $B_{a}$ and $B_{c}$, almost linearly increase with pressure, and the former is always smaller than the latter. The ratio of $B_{c}/B_{a}$ has a trend of gradual increase as the pressure increases. It is found that the elastic constants, anisotropy and Debye temperature of Ti2SC increase with pressure, while axial compressibility along the - and -axes decreases with pressure. The thermal properties including the equation of state, the Grüneisen parameter , the anisotropies $\\Delta_{p}, \\Delta_{S1}$ and $\\Delta_{S2}$, and the heat capacity are estimated at various pressures and temperatures.

  12. Advanced fusion reactor design using remountable HTc SC magnet

    International Nuclear Information System (INIS)

    A new concept of fusion reactor design is proposed using remountable high critical temperature (HTc) superconducting (SC) magnet. There are two advantages using this system. First one is that the magnet system can be composed by parts, which means it easy to replace the damaged magnet module. The second one is that it becomes possible to access the reactor first wall easily. In order to realize this system, we have performed experiments using HTc SC tape. The experimental results indicate that the resistance of the jointed region becomes about 60 μΩ, which shows the feasibility of this concept. Using this system the remountable first wall system also has the feasibility based on thermomechanical analysis. (author)

  13. Conceptual Design of the TPF-O SC Buses

    Science.gov (United States)

    Purves, Lloyd R.

    2007-01-01

    The Terrestrial Planet Finder - Occulter (TPF-O) mission has two Spacecraft (SC) buses, one for a space telescope and the other for a formation-flying occulter. SC buses typically supply the utilities (support structures, propulsion, attitude control, power, communications, etc) required by the payloads. Unique requirements for the occulter SC bus are to provide the large delta V required for the slewing maneuvers of the occulter, and comunications for formation flying. The TPF-O telescope SC bus shares some key features of the one for the Hubble Space Telescope (HST): both support space telescopes designed to observe in the visible to near infrared range of wavelengths with comparable primary mirror apertures (2.4 m for HST, 2.4 - 4.0 m for TPF-O). However, TPF-O is expected to have a Wide Field Camera (WFC) with a Field of View (FOV) much larger than that of HST. Ths WFC is also expected to provide fine guidance. TPF-O is designed to operate in an orbit around the Sun-Earth Lagrange 2 (SEL2) point. The longer communications range to SEL2 and the large science FOV require higher performance communications than HST. Maintaining a SEL2 orbit requires TPF-O, unlike HST, to have a propulsion system. The velocity required for reachng SEL2 and the limited capabilities of affordable launch vehicles require both TPF-O elements to have compact, low-mass designs. Finally, it is possible that TPF-O may utilize a modular design derived fiom that of HST to allow servicing in the SEL2 orbit.

  14. Performance Analysis of OFDM 60GHz System and SC-FDE 60GHz System

    Directory of Open Access Journals (Sweden)

    Han Xueyan

    2016-01-01

    Full Text Available In this paper, the performance of 60GHz wireless communication system with SC and OFDM is studied, the models of OFDM 60GHz system and SC 60GHz frequency domain equalization (SC-FDE system are established, and the bit error rate (BER performance of OFDM 60GHz system and SC-FDE 60GHz system in 802.15.3c channels is compared. The simulation results show that SC-FDE 60GHz system has a slight advantage over OFDM system in line-of-sight (LOS channels, while OFDM 60GHz system has a slight advantage over SC-FDE system in non-line-of-sight (NLOS channels. For 60GHz system, OFDM 60GHz system has a slight advantage over SC-FDE system in overcoming multipath fading, but the performance of both is close whether in the LOS or NLOS case.

  15. QUALITY MANAGEMENT OF BAKERY PRODUCTS: A CASE STUDY IN SC

    Directory of Open Access Journals (Sweden)

    Nicoleta- Luminiţa STRÂMBEANU RISTEA

    2013-01-01

    Full Text Available The paper aimed to present the benefits of implementing HACCP (Hazard Analysis and Critical Control Points to company S.C. "DOBRE AND SONS" S.R.L. Constanta, Romania. The data have been provided by the above mentioned manufacturer. The objectives of S.C. "DOBRE AND SONS" S.R.L. are protecting the health of the consumers of the products and their satisfaction regarding the consumption of products that are nutritional, tasty, fresh, free from microbiological, chemical and physical hazard, as well as possessing stable properties during the validity for consumption. In this respect, there has been implemented and maintained an integrated management system of food quality and safety according to SR EN ISO 9001:2008, SR EN ISO 22000:2005 and according to IFS standard, version 5/2007, which consists of determining the potential biological, chemical and physical hazards that might affect the safety of bread and bakery products, or the health of the consumer. HACCP team is analyzing hazard using one of the recommended techniques: brainstorming or the cause - effect diagram. In conclusion, the company S.C. "DOBRE AND SONS" S.R.L. Constanta, Romania provides awareness and employee involvement at all levels in achieving the appointed objectives.

  16. Scandium(III) complexes of monophosphorus acid DOTA analogues: a thermodynamic and radiolabelling study with (44)Sc from cyclotron and from a (44)Ti/(44)Sc generator.

    Science.gov (United States)

    Kerdjoudj, R; Pniok, M; Alliot, C; Kubíček, V; Havlíčková, J; Rösch, F; Hermann, P; Huclier-Markai, S

    2016-01-28

    The complexation ability of DOTA analogs bearing one methylenephosphonic (DO3AP) or methylenephosphinic (DO3AP(PrA) and DO3AP(ABn)) acid pendant arm toward scandium was evaluated. Stability constants of their scandium(iii) complexes were determined by potentiometry combined with (45)Sc NMR spectroscopy. The stability constants of the monophosphinate analogues are somewhat lower than that of the Sc-DOTA complex. The phosphorus acid moiety interacts with trivalent scandium even in very acidic solutions forming out-of-cage complexes; the strong affinity of the phosphonate group to Sc(iii) precludes stability constant determination of the Sc-DO3AP complex. These results were compared with those obtained by the free-ion selective radiotracer extraction (FISRE) method which is suitable for trace concentrations. FISRE underestimated the stability constants but their relative order was preserved. Nonetheless, as this method is experimentally simple, it is suitable for a quick relative comparison of stability constant values under trace concentrations. Radiolabelling of the ligands with (44)Sc was performed using the radioisotope from two sources, a (44)Ti/(44)Sc generator and (44m)Sc/(44)Sc from a cyclotron. The best radiolabelling conditions for the ligands were pH = 4, 70 °C and 20 min which were, however, not superior to those of the parent DOTA. Nonetheless, in vitro behaviour of the Sc(iii) complexes in the presence of hydroxyapatite and rat serum showed sufficient stability of (44)Sc complexes of these ligands for in vivo applications. PET images and ex vivo biodistribution of the (44)Sc-DO3AP complex performed on healthy Wistar male rats showed no specific bone uptake and rapid clearance through urine. PMID:26675416

  17. Electrochemical formation of Sc-Al intermetallic compounds in the eutectic LiCl-KCl. Determination of thermodynamic properties

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • The formation mechanism of AlxScy intermetallic compounds was studied in the eutectic LiCl-KCl • The formation energy, global and consecutive formation constants of AlxScy were estimated from OCP. • XRD after potentiostatic electrolysis, allowed the identification of Al3Sc and Al2Sc • XRD after intermittent galvanostatic electrolysis allowed the identification of Al3Sc, Al2Sc and AlSc2 • SEM with EDX, allowed the identification of Al3Sc, Al2Sc, AlSc and AlSc2. - Abstract: The electrochemical formation of Sc-Al alloys was investigated in the eutectic LiCl-KCl by cyclic voltammetry and open circuit chronopotentiometry. On reactive Al electrode the electrochemical reduction of Sc(III) was observed at less cathodic potential values than at the surface of an inert W electrode, the potential shift is caused by the decrease of Sc activity in the metal phase due to the formation of Sc-Al intermetallic compounds at the interface. The formation mechanism of the intermetallic compounds was studied in a melt containing: (i) both Sc(III) and Al(III) ions, using a W electrode, and ii) Sc(III) ions using an Al electrode. Analysis of the samples after electrolysis runs by X-ray diffraction allowed the identification of Al3Sc and Al2Sc, whereas analysis by scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS), allowed the identification of Al3Sc, Al2Sc, AlSc and AlSc2. The formation energy of each AlxScy intermetallic compound, and the global and stepwise formation constant were estimated from open circuit chronopotentiometry measurements in the eutectic LiCl-KCl at 723 and 773 K using Al as working electrode

  18. Al-Mg-Sc-Zr合金的再结晶%Recrystallization of Al-Mg-Sc-Zr Alloys

    Institute of Scientific and Technical Information of China (English)

    张永红; 尹志民; 张杰; 潘青林; 彭志辉

    2002-01-01

    研究了添加微量Sc,Zr的Al-Mg合金的再结晶行为,结果表明:Al-Mg-Sc-Zr合金的再结晶起始温度为400℃,细小、弥散、与基体共格的析出相对位错和亚晶的钉扎作用是合金再结晶温度大幅度提高的主要原因,再结晶形核机制为亚晶聚合机制.%The recrystalization behavior of Al-Mg alloys with Sc and Zr additives was studied.It is found that the recrystallization of the alloy began at 400℃.The main reason of the great increase of recrystallization temperature is attributed to that the dislocations and subgrain boundaries.The recrystallizing nucleation mechanism was the subgrain boundary merging mechanism in the alloy are pinned by ultrafine dispersed coherent precipitates.

  19. On 3d bonding in the transition metal trimers - The electronic structure of equilateral triangle Ca3, Sc3, Sc3(+), and Ti3(+)

    Science.gov (United States)

    Walch, S. P.; Bauschlicher, C. W., Jr.

    1985-01-01

    It is pointed out that transition metals and transition metal (TM) compounds are currently of considerable interest because of their relevance to catalysis and to materials science problems such as hydrogen embrittlement and crack propagation in metals. The present paper is concerned with complete active space Self-Consistent Field (SCF) externally contracted configuration interaction (CASSCF/CCI) calculations for the low-lying states of Sc3 and Sc3(+). A comparison is conducted regarding the bonding in the Ca3, Sc3, and Cu3 molecules. This comparison makes it possible to predict general trends for the TM trimers. Attention is given to the qualitative features of the bonding in the TM trimers, the basis sets and other technical details of the calculations, the calculated results for Sc3 and Sc3(+), and conclusions from this work.

  20. Directed evolution of human scFvs in DT40 cells.

    Science.gov (United States)

    Lim, Alfred W Y; Williams, Gareth T; Rada, Cristina; Sale, Julian E

    2016-02-01

    Cells that constitutively diversify their immunoglobulin genes can be used for selection of novel antibodies and for refining existing affinities and specificities. Here, we report an adaptation of the chicken DT40 system wherein its capacity for somatic hypermutation is harnessed to evolve human antibodies expressed as single-chain variable fragments (scFvs). Expression of membrane-anchored scFvs from within the rearranged Igλ locus created self-diversifying scFv libraries from which we could both select scFvs of a desired specificity and evolve both the specificity and affinity of existing scFvs by iterative expansion and selection. From these scFvs, we were able to create fully human IgG antibodies with nanomolar affinities. We further enhanced the functionality of the system by creating a pool of DT40 scFv lines with high levels of mutation driven by the overexpression of a hyperactive variant of activation-induced deaminase. From this library, we successfully isolated scFvs that bound the spliceosome factor CWC15 and the cytokine human IFNγ. Our results demonstrate the flexibility and utility of DT40 for rapid generation of scFv repertoires and efficient selection, evolution and affinity maturation of scFv specificities.

  1. The calculated rovibronic spectrum of scandium hydride, ScH

    CERN Document Server

    Lodi, Lorenzo; Tennyson\\, Jonathan

    2015-01-01

    The electronic structure of six low-lying electronic states of scandium hydride, $X\\,{}^{1}\\Sigma^+$, $a\\,{}^{3}\\Delta$, $b\\,{}^{3}\\Pi$, $A\\,{}^{1}\\Delta$ $c\\,{}^{3}\\Sigma^+$, and $B\\,{}^{1}\\Pi$, is studied using multi-reference configuration interaction as a function of bond length. Diagonal and off-diagonal dipole moment, spin-orbit coupling and electronic angular momentum curves are also computed. The results are benchmarked against experimental measurements and calculations on atomic scandium. The resulting curves are used to compute a line list of molecular ro-vibronic transitions for $^{45}$ScH.

  2. Wind power characterization in the Lages city - SC, Brazil

    OpenAIRE

    Olívio José Soccol; Danieli Bariviera Zitterell; Mario Nestor Ullmann; David José Miquelluti

    2010-01-01

    The main objective of this work was to determinate the nominal wind and the wind power, based on mathematical adjustments in the Lages city, SC-Brazil. The study used data comprising the period between 1976 and 2006. The wind average velocity was osted by Lages Meteorological Station located at 27º49'S, 50º12' W, and 937 meters of altitude. For the estimated wind temporal distribution, a methodology based on wind velocity curves was used. The nominal velocity that made wind power maximum in L...

  3. Scalable Implementation of Finite Elements by NASA _ Implicit (ScIFEi)

    Science.gov (United States)

    Warner, James E.; Bomarito, Geoffrey F.; Heber, Gerd; Hochhalter, Jacob D.

    2016-01-01

    Scalable Implementation of Finite Elements by NASA (ScIFEN) is a parallel finite element analysis code written in C++. ScIFEN is designed to provide scalable solutions to computational mechanics problems. It supports a variety of finite element types, nonlinear material models, and boundary conditions. This report provides an overview of ScIFEi (\\Sci-Fi"), the implicit solid mechanics driver within ScIFEN. A description of ScIFEi's capabilities is provided, including an overview of the tools and features that accompany the software as well as a description of the input and output le formats. Results from several problems are included, demonstrating the efficiency and scalability of ScIFEi by comparing to finite element analysis using a commercial code.

  4. Preparation and characterization of Sc doped MgB2 wires

    Science.gov (United States)

    Grivel, J.-C.; Burdusel, M.

    2016-09-01

    The in-situ technique was used to manufacture scandium (Sc) doped MgB2 wires in a composite Cu-Nb sheath. After reaction at 700 °C, at most 1 at.% Mg was replaced by Sc in the MgB2 phase, without significant influence on its superconducting transition temperature. For higher Sc concentrations in the nominal composition, the formation of Sc-rich impurity phases was evidenced by SEM/EDS observations. The critical current density and accommodation field of the wires are weakly dependant on the Sc content. It is believed that these effects are related more to modifications of the thermal behaviour of the precursor powders revealed by DTA measurements than to actual doping. The best performance was obtained in a wire with Mg:Sc = 0.995_0.005 atomic ratio.

  5. Toward low-cost affinity reagents: lyophilized yeast-scFv probes specific for pathogen antigens.

    Directory of Open Access Journals (Sweden)

    Sean A Gray

    Full Text Available The generation of affinity reagents, usually monoclonal antibodies, remains a critical bottleneck in biomedical research and diagnostic test development. Recombinant antibody-like proteins such as scFv have yet to replace traditional monoclonal antibodies in antigen detection applications, in large part because of poor performance of scFv in solution. To address this limitation, we have developed assays that use whole yeast cells expressing scFv on their surfaces (yeast-scFv in place of soluble purified scFv or traditional monoclonal antibodies. In this study, a nonimmune library of human scFv displayed on the surfaces of yeast cells was screened for clones that bind to recombinant cyst proteins of Entamoeba histolytica, an enteric pathogen of humans. Selected yeast-scFv clones were stabilized by lyophilization and used in detection assay formats in which the yeast-scFv served as solid support-bound monoclonal antibodies. Specific binding of antigen to the yeast-scFv was detected by staining with rabbit polyclonal antibodies. In flow cytometry-based assays, lyophilized yeast-scFv reagents retained full binding activity and specificity for their cognate antigens after 4 weeks of storage at room temperature in the absence of desiccants or stabilizers. Because flow cytometry is not available to all potential assay users, an immunofluorescence assay was also developed that detects antigen with similar sensitivity and specificity. Antigen-specific whole-cell yeast-scFv reagents can be selected from nonimmune libraries in 2-3 weeks, produced in vast quantities, and packaged in lyophilized form for extended shelf life. Lyophilized yeast-scFv show promise as low cost, renewable alternatives to monoclonal antibodies for diagnosis and research.

  6. SC1327-312 & SC1329-313 two galaxy groups in-between a major merging event observed with Beppo-SAX

    CERN Document Server

    Bardelli, S; Ettori, S; Molendi, S; Zucca, E; Colafrancesco, Sergio

    2001-01-01

    We present the results of two Beppo-SAX observations of the poor clusters SC1327-312 and SC1329-313. These objects are located in a huge structure, formed by three ACO clusters, which is probably the remnant of one of the largest and best studied major mergings known. Given the fact that these poor clusters are in between two interacting ACO clusters, the aim of this work is to study the physics of the intracluster medium and to look for the possible presence of shocks. We derived the gas distribution profiles, the global (i.e. within 0.3 Mpc) temperatures and abundances and the temperature profiles and maps for SC1327-312 and SC1329-313. Also the presence of soft excess in LECS and hard excess in PDS have been checked. We do not find evidence of regions where the gas is shocked or significantly heated. The image of SC1327-312 seems rather symmetric, while the gas profile of SC1329-313 shows disturbed, comet-like shaped isophotes, with the tail pointing toward A3562 and a compression toward SC1327-312. The pr...

  7. Characterization of PrP(Sc) transmission from immune cells to neuronal cells.

    Science.gov (United States)

    Tanaka, Yufuko; Sadaike, Tetsuji; Inoshima, Yasuo; Ishiguro, Naotaka

    2012-10-01

    We investigated PrP(Sc) transmission in neuronal cells, spleen cells and several immune cells using an in vitro cell-to-cell transmission system. The transmission of PrP(Sc) in the supernatant of PrP(Sc)-infected neuronal cells was also investigated. We found that PrP(Sc) transmission was more efficient in the cell-to-cell transmission system than in the supernatant-mediated system. PrP(Sc) was more efficiently transmitted from adherent spleen cells to neuronal cells than from floating spleen cells. The adherent spleen cells were composed of macrophages (80%), dendritic cells (8%) and follicular dendritic cells (3%), indicating that macrophages play an important role in PrP(Sc) transmission from immune cells to neuronal cells. Although PrP(Sc) in the immune cells used as donor cells was gradually degraded, the PrP(Sc) transmitted to neuronal cells was observed by Western blot analysis. Investigation of the mechanism of PrP(Sc) transmission between cells represents an important step towards understanding the pathogenesis of prion diseases. PMID:23246505

  8. Formation Processes of Nanocomposite Strengthening Particles in Rapidly Quenched Al-Sc-Zr Alloys

    OpenAIRE

    A.V. Kotko; Nosenko, V. K.; O.A. Molebny; T.O. Monastyrska; A.L. Berezina

    2012-01-01

    Decomposition processes of supersaturated solid solution of aluminium alloys alloyed with Sc and Zr have been studied in the work. The binary hypereutectic Al-Sc alloys, hyperperitectic Al-Zr alloys and ternary Al-Sc-Zr alloys were chosen. Alloys were obtained by the melt-spinning. Melts were quenched from temperatures of Т = 1000 C and Т = 1400 ºC. The study of the structure of rapidly solidifyed binary Al alloys alloyed with Sc and Zr showed that the crystallization of anomalously supersat...

  9. Model of Dees and Rotco for the 600 MeV SC

    CERN Multimedia

    1978-01-01

    The accelerating frequency of the 600 MeV Synchro-Cyclotron (SC) was modulated by the varying capacity of a rotating condenser ("Rotco", the most delicate component of the SC). A 1/5-scale model, dating from the design-period of the SC, was used to study improvements to the SC RF-system, and also the acceleration of ions, first Helium and, at the time of this picture, Carbon. In the middle of the picture is the case containing the Dees. To the left, at the wide end of the cone, a rotco. Reinhold Hohbach is busy with measurements. See also 7805235 (Annual Report 1978, p.110).

  10. Ferromagnetism carried by highly delocalized hybrid states in Sc-doped ZnO thin films

    KAUST Repository

    Benali Kanoun, Mohammed

    2012-05-29

    We present first-principles results for Sc-doped ZnOthin films. Neighboring Sc atoms in the surface and/or subsurface layers are found to be coupled ferromagnetically, where only two of the possible configurations induce spin polarization. In the first configuration, the polarization is carried by the Sc d states as expected for transition metaldoping. However, there is a second configuration which is energetically favorable. It is governed by polarized hybrid states of the Zns, O p, and Sc d orbitals. Such highly delocalized states can be an important ingredient for understanding the magnetism of dopedZnOthin films.

  11. SC&RA颁发最佳起重运输奖%SC&RA picks best jobs in rigging and hauling

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

      美国特种搬运和吊装协会(SC&RA)2007年4月10日至14日在圣安东尼奥Westin La Contera Resort饭店召开的年会上,评出了本年度的"最佳起重运输作业奖".这一奖项的出台再一次奖将人们的目光集中到美国最大和最佳的起重运输作业项目上.……

  12. Summary of the Space Charge Workshop 2013 (SC-13)

    CERN Document Server

    Franchetti, G

    2013-01-01

    This report summarizes the disucssions and conclusions from the "Space Charge 2013" (SC-13) workshop at CERN, 16-19 April 2013. SC-13 was jointly organized by EUCARD, ACCNET, ICFA, HIC4FAIR and LIU. Strong activities on space-charge related topics are ongoing at CERN (LIU), GSI (FAIR), and RAL (ISIS upgrade). Several studies include experimental work. The issue of code benchmarking is important with regard to long-term tracking. In particular, the noise created by PIC codes evoked intense discussions. Interesting from a theoretical stand point has been a discussion about equating PIC noise with intrabeam-scattering. A decision has been taken to use the GSI test suite for benchmarking of frozen space charge models also for the benchmarking of PIC codes. Firm plans have been made to benchmark Synergia and Orbit, plus perhaps also IMPACT and WARP. Other discussion focused on the role of GPU for high intensity beam dynamics. Corresponding efforts were reported from GSI, RAL, and FNAL. The final consensus is that ...

  13. V-ATPase, ScNhxlp and Yeast Vacuole Fusion

    Institute of Scientific and Technical Information of China (English)

    Quan-Sheng Qiu

    2012-01-01

    Membrane fusion is the last step in trafficking pathways during which membrane vesicles fuse with target organelles to deliver cargos.It is a central cellular reaction that plays important roles in signal transduction,protein sorting and subcellular compartmentation.Recent progress in understanding the roles of ion transporters in vacuole fusion in yeast is summanzed in this article.It is becoming increasingly evident that the vacuolar proton pump V-ATPase and vacuolar Na+/H+ antiporter ScNhxlp are key components of the vacuole fusion machinery in yeast.Yeast ScNhxlp regulates vacuole fusion by controlling the luminal pH.V-ATPases serve a dual role in vacuolar integrity in which they regulate both vacuole fusion and fission reactions in yeast.Fission defects are epistatic to fusion defects.Vacuole fission depends on the proton translocation activity of the V-ATPase; by contrast,the fusion reaction does not need the transport activity but requires the physical presence of the proton pump.Vo,the membrane-integral sector of the V-ATPase,forms trans-complexes between the opposing vacuoles in the terminal phase of vacuole fusion where the Vo trans-complexes build a continuous proteolipid channel at the fusion site to mediate the bilayer fusion.

  14. The first SC-SAGD pilot in the Grosmont

    Energy Technology Data Exchange (ETDEWEB)

    Solanki, S.C.; Barrett, K.; Riva, D.; Becker, L.; Brindle, G. [Laricina Energy Ltd. (Canada)

    2011-07-01

    In north-eastern Alberta, the Grosmont Formation is an Upper Devonian carbonate succession containing a vast amount of bitumen. In an attempt to exploit this resource, Laricina Energy Ltd. and OSUM Oil Sands Corp. built the first ever solvent-cyclic steam-assisted gravity drainage (SC-SAGD) pilot. In this process, solvent and/or steam are continuously injected at reservoir pressure to heat the reservoir and thus reduce bitumen viscosity. The aim of this paper is to present the pilot project and its initial results. The reservoir's geology, the recovery process, the drilling and completion challenges as well as the design and the operational plan are discussed in this paper. Steam injection started in December 2010 and indications show that the wells are progressing as planned. Results showed an uptime greater than 90% so far and this is expected to further improve in the future. The first SC-SAGD pilot is discussed and early phases showed excellent results from the project.

  15. scFv噬菌体库分离特异性的人源化抗D-dimer抗体%Isolation of specific humanized anti-D-dimer scFv fragments from scFv phage libraries

    Institute of Scientific and Technical Information of China (English)

    夏红利; 谭最; 陈德杰; 乔建国; 邱仁峰

    2011-01-01

    目的 从scFv(单链Fv)噬菌体抗体库分离出对D-dimer有特异性的人源化单克隆scFv.方法 对Tomlinson scFv噬菌体文库进行3轮淘洗,富集特异性的抗D-dimer抗体并进行ELISA 验证.通过酶联免疫检测和双脱氧终止法基因测序,获取特异性的人源化单克隆抗体.结果 3轮淘洗选择出38个抗D-dimer噬菌体抗体,酶联免疫和基因测序分析后,20个不同的全长单克隆抗D-dimer scFv噬菌体抗体被筛选出来,3轮选择后阳性克隆获取率为100%;分泌性抗体ELISA结果显示单克隆anti-D-dimer噬菌体顺利表达了抗体蛋白;5个A450值较高的单克隆中,3个显示了对D-dimer的高特异性和亲和力.结论 抗体噬菌体展示技术是分离获取人源化特异性anti-D-dimer抗体的高效快速方法.%Objective To isolate specific humanized anti-D-dimer scFv(single chain Fv) antibody from scFv phage libraries. Methods Isolate anti-D-dimer positive clones from Tomlinson I + J phage libraries by three rounds of panuing, then sequence monoclonal genes by bideoxy-mediated chain termination and express soluble scFv antibody; Pick out anti-D-dimer antibodies with high specificity and affinity by ELISA.Results After three rounds of selection from human scFv phage libraries Tomlinson I and J, 38 monclonal specific anti-D-dimer scFv fragments were selected. By polyclonal and monoclonal phage ELISA and gene sequencing, 20 different full-length monoclonal scFv phages were identified, the result of soluble scFv ELISA showed that 20 full-length monoclonal scFv were expressed smoothly. According to the result of soluble scFv ELISA, in 5 scFv antibodies with high value of A450 selected, 3 scFv antibody fragments showed high specific and affinity. Conclusion Antibody phage display was an effective, rapid method to isolate anti-D-dimer antibodies with high specificity and affinity.

  16. Expression and bioactivity identification of soluble MG7 scFv

    Institute of Scientific and Technical Information of China (English)

    Zhao-Cai Yu; Jie Ding; Bo-Rong Pan; Dai-Ming Fan; Xue-Yong Zhang

    2002-01-01

    AIM: To examine the molecular mass and identify thebioactivity of MG7 scFv for its application as a targetingmediator in gene therapy of gastric cancer.METHODS: Two strongly positive recombinant phage clonesscreened from MG7 recombinant phage antibody library wereseparately transfected into E. coli TG1. Plasmid wasisolated from the transfected E. coli TG1 and digested byEcoR Ⅰ and Hind Ⅲ to examine the length of exogenousscFv gene. Then, the positive recombinant phage cloneswere individually transfected into E. coli HB2151. Thetransfectant was cultured and induced by IPTG. Perplasmicextracts was prepared from the induced transfectant byosmotic shock. ELISA was used to examine the antigen-binding affinity of the soluble MG7 scFv. Immunodottingassay was adopted to evaluate the yield of soluble MG7 scFvproduced by transfected E. coli HB2151. Western blot wasused to examine the molecular mass of MG7 scFv. Finally,the nucleotide sequence of MG7 scFv was examined by DNAsequencing.RESULTS: Two positive recombinant phage clones werefound to contain the exogenous scFv gene. ELISA showedthat MG7 scFv had strong antigen-binding affinity.Immuodotting assay showed that transfected E. coli HB2151could successfully produce the soluble MG7 scFv with highyield via induction by IPTG. The molecular mass of MG7scFv was 30 kDa by western blot. DNA sequencingdemonstrated that the VH and VL genes of MG7 scFv were363bp and 321 bp, respectively.CONCLUSION: We have successfully developed the solubleMG7 scFv which possessed strong antigen-binding affinity.

  17. Effect of interfacial solute segregation on ductile fracture of Al–Cu–Sc alloys

    International Nuclear Information System (INIS)

    Three-dimensional atom probe analysis is employed to characterize the Sc segregation at θ′/α-Al interfaces in Al–2.5 wt.% Cu–0.3 wt.% Sc alloys aged at 473, 523 and 573 K, respectively. The interfacial Sc concentration is quantitatively evaluated and the change in interfacial energy caused by Sc segregation is assessed, which is in turn correlated to yield strength and ductility of the alloys. The strongest interfacial Sc segregation is generated in the 523 K-aged alloy, resulting in an interfacial Sc concentration about 10 times greater than that in the matrix and a reduction of ∼25% in interfacial energy. Experimental results show that the interfacial Sc segregation promotes θ′ precipitation and enhances the strengthening response. A scaling relationship between the interfacial energy and precipitation strengthening increment is proposed to account for the most notable strengthening effect observed in the 523 K-aged alloy, which is ∼2.5 times that in its Sc-free counterpart and ∼1.5 times that in the 473 and 573 K-aged Al–Cu–Sc alloys. The interfacial Sc segregation, however, causes a sharp drop in the ductility when the precipitate radius is larger than ∼200 nm in the 523 K-aged alloy, indicative of a transition in fracture mechanisms. The underlying fracture mechanism for the low ductility regime, revealed by in situ transmission electron microscopy tensile testing, is that interfacial decohesion occurs at the θ′ precipitates ahead of crack tip and favorably aids the crack propagation. A micromechanical model is developed to rationalize the precipitate size-dependent transition in fracture mechanisms by taking into account the competition between interfacial voiding and matrix Al rupture that is tailored by interfacial Sc segregation

  18. Synthesis and Crystal Structure of La3ScBi5%La3ScBi5的合成与晶体结构

    Institute of Scientific and Technical Information of China (English)

    潘大春; 孙忠明; 雷晓武; 毛江高

    2006-01-01

    在氩气保护下,将金属单质置于钽管中进行高温固相反应得到了一个新的三元极性金属间化合物,La3ScBi5.通过X-射线单晶衍射确定了它的晶体结构.La3ScBi5晶体属六方晶系,空间群为P63/mcm(No.193),晶胞参数为:a=b=0.97573(5)nm,c=0.65592(6)nm,V=0.54341(9)nm3,Z=2.La3ScBi5属反式Hf5Sn3Cu结构类型,其结构特征为Bi的一维直线链和由ScBi6八面体之间通过共面形成的{ScBi3}链.能带计算表明La3ScBi5呈金属导电性.%The new ternary phase, La3ScBi5 was obtained by the high temperature solid-state reactions of the pure metal elements in welded Ta tubes under argon atmosphere. Its structure was established by single-crystal X-ray diffraction. The title compound crystallizes in the hexagonal space group P63/mcm (No.193) with cell parameters of a=b=0.975 73(5) nm, c=0.655 92(6) nm, V=0.543 41(9) nm3, and Z=2. The structure of La3ScBi5 belongs to the "anti" Hf5Sn3Cu type, and features 1D linear Bi chains and {ScBi3} chains composed of face-sharing ScBi6 octahedra. Band calculations indicate that La3ScBi5 is metallic. CSD: 416609.

  19. Crystal structures of the ScCuSe{sub 2} and Sc{sub 3}CuSn{sub 3}Se{sub 11} compounds

    Energy Technology Data Exchange (ETDEWEB)

    Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@lab.univer.lutsk.ua; Shemet, V.Ya. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine); Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)

    2005-05-03

    The crystal structure of the ScCuSe{sub 2} compound was investigated using X-ray powder diffraction (space group P2, a=0.67108(5)nm, b=0.38949(3)nm, c=1.27879(6)nm, {beta}=90.281(6){sup o}, Pearson symbol mP16.08, R{sub I}=0.0839). The structure of ScCuSe{sub 2} represents a distinctive 3axax2c superstructure of Er{sub 2/3}Cu{sub 2}S{sub 2}. The Se atoms are stacked in a close-packed arrangement with layers in the sequence AB. The Sc atoms occupy half of the octahedral sites, the Cu atoms are located in 3/8 of the tetrahedral sites. The crystal structure of the Sc{sub 3}CuSn{sub 3}Se{sub 11} compound (space group Fd3m, a=1.08827(4)nm, Pearson symbol cF52.48, R{sub I}=0.0386) was also determined by means of X-ray powder diffraction. The Se atoms are stacked in a close-packed arrangement with layers in the sequence ABC. The Sc atoms and a statistical mixture M (Sc+Sn) are located in all octahedral sites, the Cu atoms in 1/8 of the tetrahedral sites.

  20. NiO-ScSZ and Ni 0.9Mg 0.1O-ScSZ-based anodes under internal dry reforming of simulated biogas mixtures

    Science.gov (United States)

    Shiratori, Y.; Sasaki, K.

    Solid oxide fuel cells (SOFCs) with NiO-ScSZ and Ni 0.9Mg 0.1O-ScSZ-based anodes were operated by directly feeding a fuel mixture of CH 4, CO 2 and N 2 (CH 4 to CO 2 ratio of 3:2). Stable operation under constant current load (200 mA cm -2) was achieved with a NiO-ScSZ type anode during 200 h operating hours at 900 °C. Less stable operation occurred with a Ni 0.9Mg 0.1O-ScSZ type anode. In the case of SOFC with Ni 0.9Mg 0.1O-ScSZ as the anode, the methane reforming activity was higher than that with NiO-ScSZ. This was explained by change in the microstructure promoting reforming reactions. However, the addition of MgO resulted in degradation of electrochemical performance due to increase in ohmic resistance of the anode material during operation.

  1. NMR study of the AF-SC-SC-AF phased transition in a pnictide superconductor LaFeAsO1-xHx

    Science.gov (United States)

    Fujiwara, Naoki; Sakurai, Ryosuke; Iimura, Soushi; Matsuishi, Satoru; Hosono, Hideo; Yamakawa, Youichi; Kontani, Hiroshi

    2014-03-01

    We have performed 75As and 1H NMR measurements in LaFeAsO1xHx, an isomorphic compound of LaFeAsO1xFx. LaFeAsO1xHx is an electron doped system, and O2- can be replaced with H- up to x = 0.5. LaFeAsO1xHx is known for having double superconducting (SC) domes on H doping. Recently, we discovered that a new antiferromagnetic (AF) phase follows the double SC domes on further H doping, forming a symmetric AF-SC-SC-AF phase alignment in the electronic phase diagram Unlike the AF ordering in the lightly H-doped regime, the AF ordering in the highly H-doped regime is attributed to the nesting between electron pockets. In the conference, we will show the data of both NMR spectra and the relaxation rate 1/T1 in the whole doping region. We will discuss the difference of electronic states between the lightly H-doped AF-SC phases and highly H-doped SC-AF phases. This work is supported by a Grant-in-Aid (Grant No. KAKENHI 23340101) from the Ministry of Education, Science, and Culture, Japan.

  2. SC-535, a Novel Oral Multikinase Inhibitor, Showed Potent Antitumor Activity in Human Melanoma Models

    Directory of Open Access Journals (Sweden)

    Xin Chen

    2013-07-01

    Full Text Available Background: Melanoma is considered as one of the most aggressive and deadliest cancers and current targeted therapies of melanoma often suffer limited efficacy or drug resistance. Discovery of novel multikinase inhibitors as anti-melanoma drug candidates is still needed. Methods: In this investigation, we assessed the in vitro and in vivo anti-melanoma activities of SC-535, which is a novel small molecule multikinase inhibitor discovered by us recently. We analyzed inhibitory effects of SC-535 on various melanoma cell lines and human umbilical vascular endothelial cells (HUVEC in vitro. Tumor xenografts in athymic mice were used to examine the in vivo activity of SC-535. Results: SC-535 could efficiently inhibit vascular endothelial growth factor receptor (VEGFR 1/2/3, B-RAF, and C-RAF kinases. It showed significant antiangiogenic potencies both in vitro and in vivo and considerable anti-proliferative ability against several melanoma cell lines. Oral administration of SC-535 resulted in dose-dependent suppression of tumor growth in WM2664 and C32 xenograft mouse models. Studies of mechanisms of action indicated that SC-535 suppressed the tumor angiogenesis and induced G2/M phase cell cycle arrest in human melanoma cells. SC-535 possesses favorable pharmacokinetic properties. Conclusion: All of these results support SC-535 as a potential candidate for clinical studies in patients with melanoma.

  3. 33 CFR 165.708 - Safety/Security Zone; Charleston Harbor and Cooper River, Charleston, SC.

    Science.gov (United States)

    2010-07-01

    ... Harbor and Cooper River, Charleston, SC. 165.708 Section 165.708 Navigation and Navigable Waters COAST... Guard District § 165.708 Safety/Security Zone; Charleston Harbor and Cooper River, Charleston, SC. (a... Cooper River. All coordinates referenced use datum: NAD 1983. (2) All waters within 100 yards of...

  4. Structural and electronic studies of metal carbide clusterfullerene Sc2C2@Cs-C72

    Science.gov (United States)

    Feng, Yongqiang; Wang, Taishan; Wu, Jingyi; Feng, Lai; Xiang, Junfeng; Ma, Yihan; Zhang, Zhuxia; Jiang, Li; Shu, Chunying; Wang, Chunru

    2013-07-01

    We present a metal carbide clusterfullerene Sc2C2@Cs(10528)-C72, whose structure has been baffling for many years. A motional endohedral Sc2C2 cluster, special molecule geometry and electronic structure were found in Sc2C2@Cs(10528)-C72. The paramagnetic Sc2C2@Cs-C72 anion radical was successfully prepared by a chemical reduction method and hyperfine couplings in the ESR spectrum were observed.We present a metal carbide clusterfullerene Sc2C2@Cs(10528)-C72, whose structure has been baffling for many years. A motional endohedral Sc2C2 cluster, special molecule geometry and electronic structure were found in Sc2C2@Cs(10528)-C72. The paramagnetic Sc2C2@Cs-C72 anion radical was successfully prepared by a chemical reduction method and hyperfine couplings in the ESR spectrum were observed. Electronic supplementary information (ESI) available: Experimental details, HPLC chromatogram, and DFT calculations. CCDC 917712. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3nr01739g

  5. Implementation of LTE SC-FDMA on the USRP2 Software Defined Radio Platform

    DEFF Research Database (Denmark)

    Jørgensen, Peter Bjørn; Hansen, Thomas Lundgaard; Sørensen, Troels Bundgaard;

    2011-01-01

    In this paper we discuss the implementation of a Single Carrier Frequency Division Multiple Access (SC-FDMA) transceiver running over the Universal Software Radio Peripheral 2 (USRP2). SC-FDMA is the air interface which has been selected for the uplink in the latest Long Term Evolution (LTE...

  6. Renormalized molecular levels in a Sc3N@C-80 molecular electronic device

    DEFF Research Database (Denmark)

    Larade, Brian; Taylor, Jeremy Philip; Zheng, Q. R.;

    2001-01-01

    We address several general questions about quantum transport through molecular systems by an ab initio analysis of a scandium-nitrogen doped C-80 metallofullerene device. Charge transfer from the Sc3N is found to drastically change the current-voltage characteristics: the current through the Sc3N...

  7. 76 FR 54703 - Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC

    Science.gov (United States)

    2011-09-02

    ... Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC in the Federal Register (76 FR 124). We received... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY:...

  8. 77 FR 74472 - Application to Export Electric Energy; Energia Renovable S.C., LLC

    Science.gov (United States)

    2012-12-14

    ... Application to Export Electric Energy; Energia Renovable S.C., LLC AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Energia Renovable S.C., LLC (Energia... 402(f) of the Department of Energy Organization Act (42 U.S.C. 7151(b), 7172(f)) and...

  9. M.Sc. in Civil and Structural Engineering

    DEFF Research Database (Denmark)

    Clausen, Johan Christian

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd...... semester projects at the M.Sc. programme in Civil and Structural Engineering. Each project description provides a brief overview of the purpose as well as the main activities. Further, a weighting between theoretical analysis, experimental work and computer modelling has been proposed. Usually...... page. Furthermore, other ideas for projects may be discussed with a potential supervisor. Many private engineering companies have a homepage on which they state that they would like to collaborate with students on a master project....

  10. INTERVIU CU DOAMNA SIMONA CAROBENE, ADMINISTRATORUL SC PROIECT MOZAIC SRL

    OpenAIRE

    Gheorghe Pascaru

    2013-01-01

    Fabrica de mozaic, înregistrată la Oficiul Registrului Comerţului în aprilie 2012 a luat fiinţă în cadrul unui proiect cu finanţare europeană nerambursabilă și are în prezent statutul de unitate protejată autorizată. În cadrul acesteia sunt angajați 10 tineri post instituţionalizați, pentru care integrarea în viaţa socială şi profesională este dificilă. Întreprinderea socială SC Proiect Mozaic SRL este rezultatul întâlnirii dintre sectorul social, non-profit şi sectorul business, deoarece are...

  11. Mises en scène du racisme italien

    OpenAIRE

    Gallini, Clara

    2007-01-01

    Traduit de l'italien par Giordana Charuty « Chers Italiens vous êtes racistes » Ainsi titre, le 17 mai 1988, Il Corriere della Sera, un des quotidiens italiens au plus fort tirage. Des titres analogues figurent sur les autres journaux. C'est la première fois que le mot racisme apparaît en première page et que les médias braquent leurs projecteurs sur ce phénomène. A partir de ce moment-là, on va assister, en Italie, à une mise en scène inédite d'actes racistes dont la violence se charge de s...

  12. DC-SC Photoinjector with Low Emittance at Peking University

    CERN Document Server

    Xiang Rong; Hao, J; Huang, Senlin; Lu Xiang Yang; Quan, Shengwen; Zhang, Baocheng; Zhao, Kui

    2005-01-01

    High average power Free Electron Lasers require the high quality electron beams with the low emittance and the sub-picosecond bunches. The design of DC-SC photoinjector, directly combining a DC photoinjector with an SRF cavity, can produce high average current beam with moderate bunch charge and high duty factor. Because of the DC gun, the emittance increases quickly at the beginning, so a carefully design is needed to control that. In this paper, the simulation of an upgraded design has been done to lower the normalized emittance below 1.5mm·mrad. The photoinjector consists of a DC gap and a 2+1/2-cell SRF cavity, and it is designed to produce 4.2 MeV electron beams at 100pC bunch charge and 81.25MHz repetition rate (8 mA average current).

  13. AlScN thin film based surface acoustic wave devices with enhanced microfluidic performance

    Science.gov (United States)

    Wang, W. B.; Fu, Y. Q.; Chen, J. J.; Xuan, W. P.; Chen, J. K.; Wang, X. Z.; Mayrhofer, P.; Duan, P. F.; Bittner, A.; Schmid, U.; Luo, J. K.

    2016-07-01

    This paper reports the characterization of scandium aluminum nitride (Al1-x Sc x N, x  =  27%) films and discusses surface acoustic wave (SAW) devices based on them. Both AlScN and AlN films were deposited on silicon by sputtering and possessed columnar microstructures with (0 0 0 2) crystal orientation. The AlScN/Si SAW devices showed improved electromechanical coupling coefficients (K 2, ~2%) compared with pure AlN films (hardness of the AlN film decreased significantly when Sc was doped, and this was responsible for the decreased acoustic velocity and resonant frequency, and the increased temperature coefficient of frequency, of the AlScN SAW devices.

  14. Sc(2)MgGa(2) and Y(2)MgGa(2).

    Science.gov (United States)

    Sahlberg, Martin; Andersson, Yvonne

    2009-03-01

    Scandium magnesium gallide, Sc(2)MgGa(2), and yttrium magnesium gallide, Y(2)MgGa(2), were synthesized from the corresponding elements by heating under an argon atmosphere in an induction furnace. These intermetallic compounds crystallize in the tetragonal Mo(2)FeB(2)-type structure. All three crystallographically unique atoms occupy special positions and the site symmetries of (Sc/Y, Ga) and Mg are m2m and 4/m, respectively. The coordinations around Sc/Y, Mg and Ga are pentagonal (Sc/Y), tetragonal (Mg) and triangular (Ga) prisms, with four (Mg) or three (Ga) additional capping atoms leading to the coordination numbers [10], [8+4] and [6+3], respectively. The crystal structure of Sc(2)MgGa(2 )was determined from single-crystal diffraction intensities and the isostructural Y(2)MgGa(2) was identified from powder diffraction data. PMID:19265212

  15. Effect of Sc addition on microstructure and mechanical properties of 1460 alloy

    Directory of Open Access Journals (Sweden)

    Juan Ma

    2014-02-01

    Full Text Available The effect of minor addition of Sc on microstructure, age hardening behavior, tensile properties and fracture morphology of 1460 alloy have been studied. It is found that Sc content increase from 0.11 wt% to 0.22 wt% is favorable for grain refinement in as-cast alloy but results in a coarsening of Cu-rich particles. The alloy with 0.11 wt% Sc exhibits enhanced mechanical properties and age hardening effect. Transmission electron microscopy (TEM investigations on the alloy with 0.11 wt% Sc have suggested that a large amount of Al3(Sc, Zr particles precipitated at the earlier aging may inhibit recrystallization effectively.

  16. Nuclear level densities and gamma-ray strength functions in 44,45Sc

    CERN Document Server

    Larsen, A C; Chankova, R; Lönnroth, T; Messelt, S; Ingebretsen, F; Rekstad, J; Schiller, A; Siem, S; Syed, N U H; Voinov, A

    2007-01-01

    The scandium isotopes 44,45Sc have been studied with the 45Sc(3He,alpha gamma)44Sc and 45Sc(3He,3He' gamma)45Sc reactions, respectively. The nuclear level densities and gamma-ray strength functions have been extracted using the Oslo method. The experimental level densities are compared to calculated level densities obtained from a microscopic model based on BCS quasiparticles within the Nilsson level scheme. This model also gives information about the parity distribution and the number of broken Cooper pairs as a function of excitation energy. The experimental gamma-ray strength functions are compared to theoretical models of the E1, M1, and E2 strength, and to data from (gamma,n) and (gamma,p) experiments. The strength functions show an enhancement at low gamma energies that cannot be explained by the present, standard models.

  17. Homogenization and Recrystallization of Al-6Mg Alloys with and without Sc and Zr

    Institute of Scientific and Technical Information of China (English)

    姜锋; 尹志民; 黄伯云; 贺跃辉; 陈苏里

    2004-01-01

    Plates of Al-6Mg alloys with and without scandium were prepared by semi-continuous cast, homogenization, hot-rolled, cold-rolled and annealing. Based on studying of effects of temperature and time on hardness and conductivity during homogenization, it was found that homogenization of ingot with Sc and Zr can result in dispersion strengthening. Recrystallization temperature of alloys was studied by hardness method and optical metallographic method. Staring recrystallization temperature of Al-6Mg alloys with Sc and Zr is 375 ℃, increasing by 150 ℃ than Al-6Mg alloys without Sc and Zr. Mechanical properties (σb, σ0.2, δ) of hot-rolled alloy with Sc and Zr are 400 MPa, 280 MPa and 18%; cold-rolled and anneal alloy with Sc and Zr are 420 MPa, 310 MPa and 12% respectively.

  18. [Construction and panning of scFv phage display library against recombinant interleukin 4 receptor].

    Science.gov (United States)

    Yang, Guangyong; Guo, Haitao; Liu, Ximing; He, Guangzhi; Tian, Weiyi; Cai, Kun; Wang, Ping; Wang, Wenjia

    2016-06-01

    Objective To construct the recombinant human interleukin 4 receptor (rhIL-4R) single-chain Fv (scFv) antibody library by phage display technique to obtain the anti-IL-4R scFv clones selected from the library. Methods Total RNA was extracted from splenocytes of the BALB/c mice immunized with rhIL-4R. Complementary DNA fragments of variable heavy (VH) and variable light (VL) chains of the antibodies were prepared by reverse transcription PCR and assembled into scFv by splice overlap extension PCR (SOE-PCR). Both scFv and the pCANTAB5E vector were respectively double-digested with restriction endonuclease Sfi I and Not I, connected with T4 ligase, and then transformed into the competent cells E.coli TG1; it was cultured in medium to obtain the phage scFv antibody library; after three rounds of enrichment and panning, the specific antigen scFv with high affinity was selected for the sequencing. Results After three rounds of panning, we obtained a diversity of approximately 2×10(8) anti-rhIL-4R scFv antibody library. Sequencing analysis of one positive clone showed that the anti-rhIL-4R scFv was 741 bp and coded 247 amino acids. The analysis of VBASE2 database indicated that VH and VL gene sequences of anti-rhIL-4R protein all had three complementarity determining regions and four backbone areas.Conclusion The anti-rhIL-4R scFv was obtained from the scFv antibody library. PMID:27371853

  19. Synthesis and Isolation of the Titanium-Scandium Endohedral Fullerenes-Sc2 TiC@Ih -C80 , Sc2 TiC@D5h -C80 and Sc2 TiC2 @Ih -C80 : Metal Size Tuning of the Ti(IV) /Ti(III) Redox Potentials.

    Science.gov (United States)

    Junghans, Katrin; Ghiassi, Kamran B; Samoylova, Nataliya A; Deng, Qingming; Rosenkranz, Marco; Olmstead, Marilyn M; Balch, Alan L; Popov, Alexey A

    2016-09-01

    The formation of endohedral metallofullerenes (EMFs) in an electric arc is reported for the mixed-metal Sc-Ti system utilizing methane as a reactive gas. Comparison of these results with those from the Sc/CH4 and Ti/CH4 systems as well as syntheses without methane revealed a strong mutual influence of all key components on the product distribution. Whereas a methane atmosphere alone suppresses the formation of empty cage fullerenes, the Ti/CH4 system forms mainly empty cage fullerenes. In contrast, the main fullerene products in the Sc/CH4 system are Sc4 C2 @C80 (the most abundant EMF from this synthesis), Sc3 C2 @C80 , isomers of Sc2 C2 @C82 , and the family Sc2 C2 n (2 n=74, 76, 82, 86, 90, etc.), as well as Sc3 CH@C80 . The Sc-Ti/CH4 system produces the mixed-metal Sc2 TiC@C2 n (2 n=68, 78, 80) and Sc2 TiC2 @C2 n (2 n=80) clusterfullerene families. The molecular structures of the new, transition-metal-containing endohedral fullerenes, Sc2 TiC@Ih -C80 , Sc2 TiC@D5h -C80 , and Sc2 TiC2 @Ih -C80 , were characterized by NMR spectroscopy. The structure of Sc2 TiC@Ih -C80 was also determined by single-crystal X-ray diffraction, which demonstrated the presence of a short Ti=C double bond. Both Sc2 TiC- and Sc2 TiC2 -containing clusterfullerenes have Ti-localized LUMOs. Encapsulation of the redox-active Ti ion inside the fullerene cage enables analysis of the cluster-cage strain in the endohedral fullerenes through electrochemical measurements. PMID:27459520

  20. Radiolabeling of DOTATOC with the long-lived positron emitter {sup 44}Sc

    Energy Technology Data Exchange (ETDEWEB)

    Pruszynski, Marek; Majkowska-Pilip, Agnieszka [Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warszawa (Poland); Loktionova, Natalia S.; Eppard, Elisabeth [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany); Roesch, Frank, E-mail: frank.roesch@uni-mainz.de [Institute of Nuclear Chemistry, Johannes Gutenberg-University of Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz (Germany)

    2012-06-15

    The positron-emitting radionuclide {sup 44}Sc with a half-life of 3.97 h and a {beta}{sup +} branching of 94.3% is of potential interest for clinical PET. As so far it is available from a {sup 44}Ti/{sup 44}Sc generator in Mainz, where long-lived {sup 44}Ti decays to no-carrier-added (nca) {sup 44}Sc. The {sup 44}Sc is a trivalent metal cation and should be suitable for complexation with many well established bifunctional chelators conjugated to peptides or other molecular targeting vectors. Thus, the aim of this work was to investigate the potential of {sup 44}Sc for labeling of DOTA-conjugated peptides. DOTA-D-Phe{sup 1}-Tyr{sup 3}-octreotide (DOTATOC) was used as a model molecule to study and optimize labeling procedure. Reaction parameters such as buffer conditions, concentration of peptide, pH range, reaction temperature and time were optimized. Addition of 21 nmol of DOTATOC to {sup 44}Sc in ammonium acetate buffer pH 4.0 provided labeling yields >98% within 25 min of heating in an oil-bath at 95 Degree-Sign C. This time can be reduced to 3 min only by applying microwave supported heating. {sup 44}Sc-DOTATOC was found to be stable in 0.9% NaCl, PBS pH 7.4, fetal calf and human serums, and also in the presence of competing metal cations (Fe{sup 3+}, Ca{sup 2+}, Cu{sup 2+}, Mg{sup 2+}), as well as other ligand competitors, like EDTA and DTPA, even after almost 25 h incubation at 37 Degree-Sign C. Present study shows that nca {sup 44}Sc forms stable complexes with the macrocyclic ligand DOTA and that {sup 44}Sc-DOTATOC and analog targeting vectors may be synthesized for further preclinical and clinical investigations. - Highlights: Black-Right-Pointing-Pointer Labeling of somatostatin analouges with positron emitter {sup 44}Sc was tested. Black-Right-Pointing-Pointer DOTATOC was labeled with {sup 44}Sc isotope. Black-Right-Pointing-Pointer Optimal conditions for {sup 44}Sc-DOTATOC synthesis were found. Black-Right-Pointing-Pointer Stability of {sup 44}Sc

  1. Downregulation of the Musca domestica peptidoglycan recognition protein SC (PGRP-SC) leads to overexpression of antimicrobial peptides and tardy pupation.

    Science.gov (United States)

    Gao, Yifu; Tang, Ting; Gu, Jihai; Sun, Lingling; Gao, Xiaobin; Ma, Xianyong; Wang, Xiaochun; Liu, Fengsong; Wang, Jianhui

    2015-10-01

    PGRP (peptidoglycan recognition protein) is a conserved protein family that recognizes the peptidoglycan in bacterial cell wall and causes the activation of various innate immune responses. Previous studies have reported that PGRP-SCs in Drosophila dampen the activation of Immune Deficiency (Imd) pathway to microbial infection, and participate in the lifespan extension of the insects. To facilitate understanding the function of PGRP-SCs from an evolutionary angle, we identified and functionally characterized the PGRP-SC gene in the housefly Musca domestica, a species that has adapted to a septic environment much harsher than the natural habitat of Drosophila. The gene designated as MdPGRP-SC was found most abundantly expressed in the 3rd instar larvae, and is expressed at this developmental stage predominantly in the gut. MdPGRP-SC was virtually unchanged in whole larvae after a septic injury at the second larval instar, while two antimicrobial peptides (AMPs), diptericin and attacin, were upregulated in the first 24h but not later. Through dsRNA microinjection, MdPGRP-SC was knocked down by RNA interference (RNAi), and caused the significant increased expression of diptericin and attacin. The pupation of MdPGRP-SC-depleted larvae was severely suppressed compared to controls. Opposite to the expression trend of MdPGRP-SC, a spontaneous active expression of diptericin and attacin was found in pre-pupae but not in third instar larvae. Taken together, our study reveals that downregulation of MdPGRP-SC leads to the overexpression of the AMPs, and is involved in the larvae-to-pupa transition of housefly.

  2. Differential dynamics of splicing factor SC35 during the cell cycle

    Indian Academy of Sciences (India)

    Kaushlendra Tripathi; Veena K Parnaik

    2008-09-01

    Pre-mRNA splicing factors are enriched in nuclear domains termed interchromatin granule clusters or nuclear speckles. During mitosis, nuclear speckles are disassembled by metaphase and reassembled in telophase in structures termed mitotic interchromatin granules (MIGs). We analysed the dynamics of the splicing factor SC35 in interphase and mitotic cells. In HeLa cells expressing green fluorescent protein (GFP)-SC35, this was localized in speckles during interphase and dispersed in metaphase. In telophase, GFP-SC35 was highly enriched within telophase nuclei and also detected in MIGs. Fluorescence recovery after photobleaching (FRAP) experiments revealed that the mobility of GFP-SC35 was distinct in different mitotic compartments. Interestingly, the mobility of GFP-SC35 was 3-fold higher in the cytoplasm of metaphase cells compared with interphase speckles, the nucleoplasm or MIGs. Treatment of cells with inhibitors of cyclin-dependent kinases (cdks) caused changes in the organization of nuclear compartments such as nuclear speckles and nucleoli, with corresponding changes in the mobility of GFP-SC35 and GFP-fibrillarin. Our results suggest that the dynamics of SC35 are significantly influenced by the organization of the compartment in which it is localized during the cell cycle.

  3. CERN Technical Training 2004: New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 31.8.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 31.8.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 7.9.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she...

  4. Technical Training: CERN Technical Training 2004 - New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 31.8.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 31.8.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 7.9.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and s...

  5. CERN Technical Training 2004: New Short Courses (SC) on Microsoft Outlook

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) will cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled sessions will take place as follows: Outlook (SC I): E-mail. Next session: 22.10.2004 (9h00-11h00) Outlook (SC II): Calendar, Tasks and Notes. Next session: 22.10.2004 (14h00-16h00) Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14h00-16h00) In particular, SC I will cover how to open, create and send email, work with attachments, use stationery, organise mail, and work with the address book, SC II will show how to work with the calendar, tasks and notes, and SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and...

  6. Differential Attack on Five Rounds of the SC2000 Block Cipher

    Institute of Scientific and Technical Information of China (English)

    Ji-Qiang Lv

    2011-01-01

    The SC2000 block cipher has a 128-bit block size and a user key of 128,192 or 256 bits,which employs a total of 6.5 rounds if a 128-bit user key is used.It is a CRYPTREC recommended e-government cipher in Japan.In this paper we address how to recover the user key from a few subkey bits of SC2000,and describe two 4.75-round differential characteristics with probability 2-126 of SC2000 and seventy-six 4.75-round differential characteristics with probability 2-127.Finally,we present a differential cryptanalysis attack on a 5-round reduced version of SC2000 when used with a 128-bit key; the attack requires 2125.68 chosen plaintexts and has a time complexity of 212575 5-round SC2000 encryptions.The attack does not threat the security of the full SC2000 cipher,but it suggests for the first time that the safety margin of SC2000 with a 128-bit key decreases below one and a half rounds.

  7. Final Technical Report – DOE Grant DE-SC0005904

    Energy Technology Data Exchange (ETDEWEB)

    Dear, Jody [Connecticut State Univ. System, Hartford, CT (United States)

    2013-10-23

    DOE grant DE-SC0005904 was allocated to fund the faculty development, curriculum development and travel to support the four institutions of the Connecticut State University System’s (CSUS) Initiative for Nanotechnology-related Equipment, Faculty Development and Curriculum Development. DOE grant DE-SC0005072 was also awarded for this program. In 2010, CSUS had identified the establishment of nanotechnology programs and infrastructure as a priority. At that time, the system set the goal of establishing an academic initiative in nanotechnology for the CSUS, beginning with the development of a series of courses at the graduate level. Implementation was planned via a collaborative effort including faculty from all four of the CSUS campuses. The CSUS Nanotechnology Working Group [CSUS NWG] was established to accomplish this goal. A faculty member from the Physics Department at Southern Connecticut State University [SCSU] was assigned the task of organizing and coordinating the work of the CSUS NWG. Representatives from each of the four CSUS campuses were appointed to join the CSUS NWG with the following initial representation: SCSU [Physics and Biology], Western Connecticut State University (WCSU) [Chemistry], Eastern Connecticut State University (ECSU) [Chemistry] and Central Connecticut State University (CCSU) [Chemistry. As a further outcome it was determined that this collaborative effort would lead to the establishment of a formal nanotechnology center, serving as the nucleus of CSUS student and faculty learning and research. This CSUS Nanotechnology Center [CSUS-NC] was to be located at Southern Connecticut State University (SCSU). The goal of this grant was to provide funding for curriculum and faculty development necessary to facilitate the development and implementation of a collaborative Graduate Certificate in Nanotechnology for the Connecticut State University System. This outcome has been successfully achieved. The courses and structure of the Graduate

  8. EngenuitySC Commercialization and Entrepreneurial Training Project

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Meghan; Hutton, Katherine R

    2012-12-31

    A team led by EngenuitySC has performed education and outreach on development of advanced energy markets that will enable wider use of clean energy technologies. This report details the efforts that have made significant advances to improve the market place through education, outreach, and increased communications between industry members. The project resulted in two self-funded industry clusters known as the Fuel Cell Collaborative and NuHub. This project has focused on building and strengthening the leading clean energy clusters in South Carolina: nuclear energy and fuel cell technologies. For the nuclear industry, a new cluster was developed that is now known as NuHub. This cluster has already engaged over 25 nuclear industry leaders or suppliers, four public sector partners, six community economic development foundations, and nearly ten academic partners in a 175 mile radius between Augusta, Georgia and Charlotte, North Carolina. Our outreach has touched over 2,000 stakeholders through the website alone, not including the public audiences and members of the business community reached through news stories and releases that were distributed to over 620 print and online publications. NuHub has established a formal leadership structure, developed subcommittees to focus on industry issues, instituted educational programs for the workforce, and created an industry funding structure that will sustain the industry cluster and mission. NuHub has participated in a wide-variety of community building and outreach activities since its formation under this grant. In the two years since its creation in 2010, we have initiated efforts focused in four main areas that correlate with the four NuHub subcommittees including: innovation, workforce development, industry engagement, and marketing and communications. NuHub successfully raised over $160,000 in both public and private funding, which has supported work to grow the cluster and engage partners including NuScale, Fluor, and

  9. Synergistic capture of Clostridium botulinum Type A neurotoxin by scFv antibodies to novel epitopes

    Energy Technology Data Exchange (ETDEWEB)

    Gray, Sean A.; Barr, John R.; Kalb, Suzanne R.; Marks, James D.; Baird, Cheryl L.; Cangelosi, Gerard A.; Miller, Keith D.; Feldhaus, Michael J.

    2011-10-01

    A non-immune library of human single chain fragment variable (scFv) antibodies displayed on Saccharomyces cerevisiae was screened for binding to the Clostridium botulinum neurotoxin serotype A binding domain [BoNT/A (Hc)] with the goal of identifying scFv to novel epitopes. To do this, an antibody-mediated labeling strategy was used in which antigen-binding yeast clones were selected after labeling with previously characterized monoclonal antibodies (MAbs) specific to the Hc. Twenty unique scFv clones were isolated that bound Hc. Of these, three also bound to full-length BoNT/A toxin complex with affinities ranging from 5 nM to 170 nM. Epitope binning showed that the three unique clones recognized at least two epitopes that were distinct from one another and from the detection MAbs. After production in E. coli, the scFv were coupled to magnetic particles and tested for their ability to capture BoNT/A holotoxin using an Endopep-MS assay. In this assay, toxin captured by scFv coated magnetic particles was detected by incubation of the complex with a peptide containing a BoNT/A-specific cleavage sequence. Mass spectrometry was used to detect the ratio of intact peptide to cleavage products as evidence for toxin capture. When tested individually, each of the scFv showed a weak positive Endopep-MS result. However, when the particles were coated with all three scFv simultaneously, they exhibited significantly higher Endopep-MS activity, consistent with synergistic binding. These results demonstrate novel approaches toward the isolation and characterization of scFv antibodies specific to unlabeled antigen. They also provide evidence that distinct scFv antibodies can work synergistically to increase the efficiency of antigen capture onto a solid support.

  10. SC-FDMA系统基于限幅技术降低峰均比的研究%PAPR reduction in SC-FDMA system by clipping technique

    Institute of Scientific and Technical Information of China (English)

    陈茜; 李一兵; 叶方

    2009-01-01

    SC-FDMA is the uplink multiple access scheme in LTE. Localized FDMA which is a special case of SC-FDMA signal has relatively high PAPR. PAPR of LFDMA signal is reduced by means of hard limiting, soft limiting and smooth limiting respectively. Analysis and comparisons of the PAPR, anti-band noise performance and out-of-band emission based on these three methods was made. The simulation results show that in the acceptable situation of bit error rate and out-of-band emission, clipping is a simple, easy approach which can effectively reduce the PAPR of SC-FDMA signal.%SC-FDMA是LTE上行链路的多址接入方案.SC-FDMA中的集中式频分多址(LFDMA)峰均比相对较高.分别通过硬限幅、软限幅和平滑限幅的方法,降低LFDMA的峰均比,并针对这三种方法的PAPR性能,抗噪声性能和带外辐射问题进行分析比较.仿真结果表明,在允许的带外辐射和抗噪声性能情况下,限幅法是一种简单、易于实现且能有效降低发送信号峰均比的方法.

  11. Ionic conductivity of co-doped Sc2O3-ZrO2 ceramics

    DEFF Research Database (Denmark)

    Omar, Shobit; bin Najib, Waqas; Chen, Weiwu;

    2012-01-01

    The oxide ionic conductivity of Sc0.18Zr0.82O1.91 doped with 0.5 mol.% of both Yb2O3 and In2O3 is evaluated at various temperatures in air. Among various co-doped compositions, In0.02Sc0.18Zr0.80O1.90 exhibits the highest grain ionic conductivity followed by Yb0.02Sc0.18Zr0.80O1.90 at 500°C. Howe...

  12. Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription

    OpenAIRE

    Schubot, Florian D; Chen, Chun-Jung; Rose, John P.; Dailey, Tamara A.; Dailey, Harry A.; Wang, Bi-Cheng

    2001-01-01

    Although it is commonly accepted that binding of mitochondrial transcription factor sc-mtTFB to the mitochondrial RNA polymerase is required for specific transcription initiation in Saccharomyces cerevisiae, its precise role has remained undefined. In the present work, the crystal structure of sc-mtTFB has been determined to 2.6 Å resolution. The protein consists of two domains, an N-terminal α/β-domain and a smaller domain made up of four α-helices. Contrary to previous predictions, sc-mtTFB...

  13. Current Lead System of the SuperKEKB Final Focus SC Magnet Cryostats

    Science.gov (United States)

    Zong, Z. G.; Ohuchi, N.; Tsuchiya, K.; Arimoto, Y.; Higashi, N.; Yamaoka, H.; Kondou, Y.; Kawai, M.

    To energize the SuperKEKB final focus superconducting (SC) magnets, 110 current leads in total will be equipped in the two service cryostats. For the SC quadrupoles and solenoids, 22 leads are the conventional vapor cooled type and the others for the SC correction coils employ an HTS section at the cold ends. The qualification program on the leads is being carried out at KEK as the cryogenic acceptance test prior to installation. This paper presents the thermal and electrical results of the cryogenic tests.

  14. Sc-Si normal incidence mirrors for a VUV interval of 35-50 nm

    CERN Document Server

    Uspenskii, Y A; Vinogradov, A V; Fedorenko, A I; Kondratenko, V V; Pershin, Y P; Zubarev, E N; Mrowka, S; Schäfers, F

    2000-01-01

    The Sc/Si multilayers are suggested as high-reflectivity coatings for a VUV interval of 35-50 nm. Fabricated mirrors show the normal incidence reflectivity of 30-50% which is high enough to effectively manipulate the beams of synchrotron radiation and compact discharge and laser-driven X-ray lasers. The obtained values are not, however, limiting for the Sc/Si coatings. Theoretical estimations as well as electron microscopy studies of Sc-Si interfaces indicate a large potential for further raising the reflectivity.

  15. Magnetic properties of Sc{sub x}Ti{sub 1-x}Fe{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Kessler, M. [Lab. de Cristallographie, CNRS, 38 - Grenoble (France); Deportes, J. [Lab. Louis Neel, CNRS, 38 - Grenoble (France); Ouladdiaf, B. [Institut Laue-Langevin, 38 - Grenoble (France); Sayetat, F. [Lab. de Cristallographie, CNRS, 38 - Grenoble (France)

    1995-02-09

    The magnetic properties and their thermal dependences of Sc{sub 0.1}Ti{sub 0.9}Fe{sub 1.96}, Sc{sub 0.1}Ti{sub 0.9}Fe{sub 2} and Sc{sub 0.1}Ti{sub 0.9}Fe{sub 2.04} are compared with those of TiFe{sub 2}. The substitution changes the iron-iron distances. Consequently, the Fe atoms on the 6h site show in addition to the antiferromagnetic component a small ferromagnetic one, and a weak magnetic moment appears on the 2a site. ((orig.)).

  16. The OGLE-II event sc5_2859 a Classical Nova outburst?

    CERN Document Server

    Afonso, C; Andersen, J; Ansari, R; Aubourg, E; Bareyre, P; Beaulieu, J P; Blanc, G; CSmith, M; Charlot, X; Coutures, C; De Kat, J; Ferlet, R; Fouqué, P; Glicenstein, J F; Goldman, B; Gould, A; Graff, D; Gros, M; Hamadache, C; Haïssinski, J; Le Guillou, Laurent; Lesquoy, E; Loup, C; Magneville, C; Marquette, J B; Maurice, E; Maury, A; Milsztajn, A; Moniez, M; Palanque-Delabrouille, Nathalie; Perdereau, O; Prévôt, L; Rahal, Y R; Rich, J; Spiro, M; Tisserand, P; Vidal-Madjar, A; Vigroux, L; Wagner, R M; Zylberajch, S

    2006-01-01

    The OGLE-II event sc5_2859 was previously identified as the third longest microlensing event ever observed. Additional photometric observations from the EROS (Experience de Recherche d'Objets Sombres) survey and spectroscopic observations of the candidate star are used to test the microlensing hypothesis.The combined OGLE and EROS data provide a high quality coverage of the light curve. The colour of the sc5_2859 event is seen to change with time. A spectrum taken in 2003 exhibits a strong Halpha emission line. The additionnal data show that the OGLE-II sc5_2859 event is actually a classical nova outburst.

  17. Assembly of a supercrystal (SC) of the CMS endcap electromagnetic calorimeter

    CERN Multimedia

    J. Williams et al., RAL

    2004-01-01

    The first three pictures show the insertion of the first three rows of crystals into the supercrystal SC03 on Jan. 2004 and the completion of the SC endstops. Fig. 4 shows a complete supercrystal and Fig. 5 its components (alveolar, interface plate, housing, optical fibre, insert, crystal and VPT, endstop). A set of 25 inserts is shown in Fig. 6, while Fig. 7 shows housing, interface plates and inserts. Finally, a SC rear view showing the Vacum Phototriode (VPT) wires through the inserts can be seen in Fig. 8. Fig. 9 and 10 show two supercrystals under test on Dee F and R, respectively.

  18. Lanthanide-doped NaScF4 nanoprobes: crystal structure, optical spectroscopy and biodetection

    Science.gov (United States)

    Ai, Yu; Tu, Datao; Zheng, Wei; Liu, Yongsheng; Kong, Jintao; Hu, Ping; Chen, Zhuo; Huang, Mingdong; Chen, Xueyuan

    2013-06-01

    Trivalent lanthanide ions (Ln3+)-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc3+ with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu3+ at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln3+ NPs were synthesized via a facile thermal decomposition method. The biotinylated NaScF4:Er3+/Yb3+ NPs were demonstrated for their applications as a heterogeneous UC luminescence bioprobe to detect avidin with a detection limit of 180 pM. After bioconjugation with amino-terminal fragment (ATF) of urokinase plasminogen activator (uPA), NaScF4:Ln3+ NPs also exhibited specific recognition of cancer cells overexpressed with uPA receptor (uPAR, an important marker of tumor biology and metastasis), showing great potentials in tumor-targeted bioimaging.Trivalent lanthanide ions (Ln3+)-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc3+ with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu3+ at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln3+ NPs were synthesized via a facile thermal

  19. Preliminary Tests Of The Decris-sc Ion Source

    CERN Document Server

    Efremov, A; Bechterev, V; Bogomolov, S L; Bondarenko, P G; Datskov, V I; Dmitriev, S; Drobin, V; Lebedev, A; Leporis, M; Malinowski, H; Nikiforov, A; Paschenko, S V; Seleznev, V; Shishov, Yu A; Smirnov, Yu; Tsvineva, G; Yakovlev, B; Yazvitsky, N Yu

    2004-01-01

    A new "liquid He-free" superconducting Electron Cyclotron Resonance Ion Source DECRIS-SC, to be used as injector for the IC-100 small cyclotron, has been designed by FLNR and LHE JINR. The main feature is that a compact refrigerator of Gifford-McMahon type is used to cool the solenoid coils. For the reason of very small cooling power at 4.2 K (about 1 W) our efforts were to optimize the magnetic structure and minimize an external heating of the coils. The maximum magnetic field strength is 3 T and 2 T in injection and extraction region respectively. For the radial plasma confinement a hexapole made of NdFeB permanent magnet is used. The source will be capable of ECR plasma heating using different frequencies (14 GHz or 18 GHz). To be able to deliver usable intensities of solids, the design is also allow axial access for evaporation oven and metal samples using the plasma sputtering technique. Very preliminary results of the source test are presented.

  20. Transition energy and oscillator strength of Sc18+ion

    Institute of Scientific and Technical Information of China (English)

    Wang Zhi-Wen; Yang Di; Hu Mu-Hong; Han Qiu-Ju; Li Jin-Ying

    2005-01-01

    The transition energies and the dipole oscillator strengths for the 1s22s-1s2np (2 ≤ n ≤ 9) and 1s22p-1s2nd (3≤n ≤ 9) of lithium-like Sc18+ ion are calculated by using the full core plus correlation method. The fine structure splittings of 1s2np and 1s2nd (n ≤ 9) states are determined from the expectation values of spin-orbit and spin-otherorbit interaction operators. The quantum defects of these series, as function of principal quantum number n, are obtained. The agreement between the f-values obtained from three alternative formulae is excellent. Comparisons of our results with experimental data available in the literature are carried out. Combining the single-channel quantum defect theory with the discrete oscillator strengths obtained in this work, this paper obtains the behaviour of discrete oscillator strengths and oscillator strength densities corresponding to the bound-free transitions adjacent to ionization threshold.

  1. INTERVIU CU DOAMNA SIMONA CAROBENE, ADMINISTRATORUL SC PROIECT MOZAIC SRL

    Directory of Open Access Journals (Sweden)

    Gheorghe Pascaru

    2013-12-01

    Full Text Available Fabrica de mozaic, înregistrată la Oficiul Registrului Comerţului în aprilie 2012 a luat fiinţă în cadrul unui proiect cu finanţare europeană nerambursabilă și are în prezent statutul de unitate protejată autorizată. În cadrul acesteia sunt angajați 10 tineri post instituţionalizați, pentru care integrarea în viaţa socială şi profesională este dificilă. Întreprinderea socială SC Proiect Mozaic SRL este rezultatul întâlnirii dintre sectorul social, non-profit şi sectorul business, deoarece are la bază un parteneriat cu un important grup de firme din domeniul construcţiilor şi amenajărilor interioare din București. În paralel cu activitatea de producţie a mozaicului, ocazional, Proiect Mozaic oferă către clienți și servicii de ambalare și asamblare produse.

  2. Formation Processes of Nanocomposite Strengthening Particles in Rapidly Quenched Al-Sc-Zr Alloys

    Directory of Open Access Journals (Sweden)

    A.V. Kotko

    2012-03-01

    Full Text Available Decomposition processes of supersaturated solid solution of aluminium alloys alloyed with Sc and Zr have been studied in the work. The binary hypereutectic Al-Sc alloys, hyperperitectic Al-Zr alloys and ternary Al-Sc-Zr alloys were chosen. Alloys were obtained by the melt-spinning. Melts were quenched from temperatures of Т = 1000 C and Т = 1400 ºC. The study of the structure of rapidly solidifyed binary Al alloys alloyed with Sc and Zr showed that the crystallization of anomalously supersaturated solid solution (Tquen. = 1400 ºC or the crystallization with the formation of "fan" structure (Tquen. = 1000 ºC are possible depending on the quenching temperature of the melt. The decomposition of anomalously supersaturated solid solution is continuous, with the precipitation of nano-sized spherical Al3X (X-Sc, Zr particles of L12-ordered phase which is isomorphous to matrix. It was found that the loss of thermal stability of Al-Sc alloys is due to the loss of coherence of the strengthening Al3Sc phase. In Al-Zr alloys the loss of strength is due to the formation of a stable tetragonal DO23-ordered A13Zr phase. After co-alloying of Al by Sc and Zr a bimodal grained structure was observed for the hypereutectic ternary alloy (Tquen. = 400ºC. Nano-sized grains of 50-60 nm were present on the boundaries of 1-2 µm large-sized grains. TEM shows the formation of nanocomposite Al3Zr/Al3Sc particles. The formation of Al3Zr shell changes the nature of the interfacial fit of the particle with the matrix and slows down the decomposition during the coalescence. Ternary Al-Sc-Zr alloys have significantly higher thermal stability during aging as compared to binary Al-Sc and Al-Zr alloys. Decomposition processes of supersaturated solid solution of aluminium alloys alloyed with Sc and Zr have been studied in the work. The binary hypereutectic Al-Sc alloys, hyperperitectic Al-Zr alloys and ternary Al-Sc-Zr alloys were chosen. Alloys were

  3. Synthesis and Isolation of the Titanium–Scandium Endohedral Fullerenes—Sc2TiC@Ih-C80, Sc2TiC@D5h-C80 and Sc2TiC2@Ih-C80 : Metal Size Tuning of the TiIV/TiIII Redox Potentials

    Science.gov (United States)

    Junghans, Katrin; Ghiassi, Kamran B.; Samoylova, Nataliya A.; Deng, Qingming; Rosenkranz, Marco; Olmstead, Marilyn M.; Balch, Alan L.; Popov, Alexey A.

    2016-01-01

    The formation of endohedral metallofullerenes (EMFs) in an electric arc is reported for the mixed-metal Sc–Ti system utilizing methane as a reactive gas. Comparison of these results with those from the Sc/CH4 and Ti/CH4 systems as well as syntheses without methane revealed a strong mutual influence of all key components on the product distribution. Whereas a methane atmosphere alone suppresses the formation of empty cage fullerenes, the Ti/CH4 system forms mainly empty cage fullerenes. In contrast, the main fullerene products in the Sc/CH4 system are Sc4C2@C80 (the most abundant EMF from this synthesis), Sc3C2@C80, isomers of Sc2C2@C82, and the family Sc2C2n (2n=74, 76, 82, 86, 90, etc.), as well as Sc3CH@C80. The Sc–Ti/CH4 system produces the mixed-metal Sc2TiC@C2n (2n=68, 78, 80) and Sc2TiC2@C2n (2n=80) clusterfullerene families. The molecular structures of the new, transition-metal-containing endohedral fullerenes, Sc2TiC@Ih-C80, Sc2TiC@D5h-C80, and Sc2TiC2@Ih-C80, were characterized by NMR spectroscopy. The structure of Sc2TiC@Ih-C80 was also determined by single-crystal X-ray diffraction, which demonstrated the presence of a short Ti=C double bond. Both Sc2TiC- and Sc2TiC2-containing clusterfullerenes have Ti-localized LUMOs. Encapsulation of the redox-active Ti ion inside the fullerene cage enables analysis of the cluster–cage strain in the endohedral fullerenes through electrochemical measurements. PMID:27459520

  4. Report of AAPM Therapy Physics Committee Task Group 74: in-air output ratio, Sc, for megavoltage photon beams.

    Science.gov (United States)

    Zhu, Timothy C; Ahnesjö, Anders; Lam, Kwok Leung; Li, X Allen; Ma, Chang-Ming Charlie; Palta, Jatinder R; Sharpe, Michael B; Thomadsen, Bruce; Tailor, Ramesh C

    2009-11-01

    The concept of in-air output ratio (Sc) was introduced to characterize how the incident photon fluence per monitor unit (or unit time for a Co-60 unit) varies with collimator settings. However, there has been much confusion regarding the measurement technique to be used that has prevented the accurate and consistent determination of Sc. The main thrust of the report is to devise a theoretical and measurement formalism that ensures interinstitutional consistency of Sc. The in-air output ratio, Sc, is defined as the ratio of primary collision water kerma in free-space, Kp, per monitor unit between an arbitrary collimator setting and the reference collimator setting at the same location. Miniphantoms with sufficient lateral and longitudinal thicknesses to eliminate electron contamination and maintain transient electron equilibrium are recommended for the measurement of Sc. The authors present a correction formalism to extrapolate the correct Sc from the measured values using high-Z miniphantom. Miniphantoms made of high-Z material are used to measure Sc for small fields (e.g., IMRT or stereotactic radiosurgery). This report presents a review of the components of Sc, including headscatter, source-obscuring, and monitor-backscattering effects. A review of calculation methods (Monte Carlo and empirical) used to calculate Sc for arbitrary shaped fields is presented. The authors discussed the use of Sc in photon dose calculation algorithms, in particular, monitor unit calculation. Finally, a summary of Sc data (from RPC and other institutions) is included for QA purposes.

  5. Low-dimensional ScO2 with tunable electronic and magnetic properties: first-principles studies.

    Science.gov (United States)

    Zhang, Hui; Tong, Chuan-Jia; Wu, Jian; Yin, Wen-Jin; Zhang, Yan-Ning

    2016-01-13

    Transition metal dichalcogenides (TMDs) have attracted extensive attention due to their appealing properties for device applications. In this work, we explored the structure stability, electronic structure and magnetism of low-dimensional scandium dioxides, ScO2, by using the first-principles calculations. The results demonstrate that bulk ScO2, monolayers and nanoribbons (NRs) are thermodynamically stable, implying a high possibility of fabricating ScO2 nanocrystals in experiments. Despite the metallic characteristics of bulk ScO2, low-dimensional ScO2 possesses various electronic behaviors that can be further modulated by crystal structure and dimensionality. The results also show that the ground states of ScO2 monolayers and NRs are ferromagnetic (FM) with about 1 μ B per ScO2 formula. Our studies expand a new realm in low-dimensional TMDs, with tunable electronic and magnetic properties. PMID:26571138

  6. The creep behaviour of single-crystal turbine blade alloys basing on nickel SC 16 with [011] orientation; Das Kriechverhalten der einkristallinen Nickelbasisturbinenschaufellegierung SC 16 MIT [011]-Orientierung

    Energy Technology Data Exchange (ETDEWEB)

    Klingelhoeffer, H.; Chrzanowski, U.; Kraemer, E.; Frenz, H.; Ziebs, J. [Bundesanstalt fuer Materialforschung und -pruefung, Berlin (Germany)

    1997-12-31

    This paper describes the creep behaviour of single-crystal turbine blade alloys basing on nickel SC 16 compared to the material IN 738 LC while submitted to creep strain. The creep properties of samples with [011] and [001]-orientation are compared with each other. (orig./MM) [Deutsch] In der vorliegenden Arbeit wird das Kriechverhalten der einkristallinen Nickelbasissuperlegierung SC 16 im Vergleich zum Werkstoff IN 738 LC unter Kriechbeanspruchung dargestellt. Dabei werden die Kriecheigenschaften von Proben mit [011]- und [001]-Orientierung gegenuebergestellt. (orig./MM)

  7. SC-600型双气压呼吸机二次设计开发%Second Design and Development of SC-600 Type Double Pressure Breathing Machine

    Institute of Scientific and Technical Information of China (English)

    陈斌

    2016-01-01

    In view of the large noise and high failure rate of the valve of the SC-600 type double pressure breathing machine during clinical using, the paper describes the main improvement methods of the second design and development of this type of machine.%该文针对SC-600型双气压呼吸机在临床使用过程中发现的噪音过大、呼吸比例阀故障率高等质量问题,阐述了该设备的二次设计开发的主要改进方法。

  8. Synthesis and properties of Yb:Sc2O3 transparent ceramics

    Institute of Scientific and Technical Information of China (English)

    JIANG Benxue; HU Chen; LI Jiang; KOU Huamin; SHI Yun; LIU Wenbin; PAN Yubai

    2011-01-01

    Yb:Sc2O3 transparent ceramics were fabricated by solid-state reaction and vacuum sintering method.CaO was added as sintering aids by a high energy ball milling.Transparent nearly-fully dense samples were obtained after 1840 ℃ sintering.Using transmitted-light microscope we get the grain sizes are more than 1 00 μm.Using spectrophotometer we get the absorption coefficient centered at 975 nm was 2.65 cm-1.The phosphorescence spectra showed that the line-widths (FWHM) at 975 and 1041 nm were about 4 and 10 nm and the lifetime of Yb ions in Sc2O3 transparent ceramics was about 883 μs.According to the absorption and fluorescence band centers of Yb:Sc2O3 transparent ceramics,the level scheme of Yb3+ ions in Sc2O3 ceramics could be gotten.

  9. Al-rich part phase relation in Al-Mg-Sc system at 430 ℃

    Institute of Scientific and Technical Information of China (English)

    夏长清; 曾凡浩; 古一

    2003-01-01

    Phase relation of the aluminium-magnesium-scandium system in the Al-rich range at 430 ℃ was investigated by means of multiphase diffusion couples along with electron probe microanalysis, X-ray diffraction and electron microscopy techniques. It consists of five single-phase fields, four 2-phase fields and one 3-phase field. The maximum solid solubilities of Mg and Sc in α(Al) solid solution at 430 ℃ are about 15.27%Mg(mole fraction) and 0.33%Sc, respectively. The maximum solid solubilities of Sc in Mg2Al3 and Mg17Al12 are about 1.08% and 0.03% at the same temperature. The diffusion path at 430 ℃ was constructed and interpreted by means of the Al-Mg-Sc equilibrium phase diagram assuming that local equilibrium is established at the phase boundaries.

  10. The importance of chromosome studies in Roberts syndrome/SC phocomelia and other cohesinopathies

    NARCIS (Netherlands)

    Gerkes, Erica H.; van der Kevie-Kersemaekers, Anne-Marie F.; Yakin, Mariam; Smeets, Dominique F. C. M.; van Ravenswaaij-Arts, Conny M. A.

    2010-01-01

    Roberts syndrome/SC phocomelia is a rare, autosomal recessive syndrome characterised by pre- and postnatal growth retardation, microcephaly, craniofacial anomalies, mental retardation, and tetraphocomelia in varying degrees of severity. The clinical diagnosis can be challenging in phenotypically mil

  11. Damping values for seismic design of nuclear power plant SC structures

    International Nuclear Information System (INIS)

    The paper describes the research work of experimental testing method, analysis of test results and proposed damping values for seismic design of nuclear power plant SC (steel-plate concrete) structures

  12. Expression of recombinant human anti-TNF-α scFv-Fc in Arabidopsis thaliana seeds.

    Science.gov (United States)

    Yao, N; Ai, L; Dong, Y Y; Liu, X M; Wang, D Z; Wang, N; Li, X W; Wang, F W; Li, Xk; Li, H Y; Jiang, C

    2016-01-01

    Recombinant human anti-tumor necrosis factor (TNF)-α scFv-Fc was expressed in TKO mutant Arabidopsis thaliana seeds using plant-specific codons. Immunoblotting using a human IgG1 antibody detected the expression of anti-TNF-α proteins in plants. Results from qRT-PCR analysis demonstrated that the time of harvest significantly affected the protein yield and quality. Our results indicate that the Phaseolus vulgaris β-phaseolin promoter directed anti-TNF-α scFv-Fc expression in A. thaliana seeds, with a maximum yield obtained at 20-days of development. Although the yield of anti-TNF-α scFv-Fc protein was not very high, accumulation of recombinant proteins in seeds is an attractive and simple method that can be used to purify biologically active anti-TNF-α scFv-Fc. PMID:27420937

  13. Al-Cu based welding wire with minor Sc-Zr alloying and its application

    Institute of Scientific and Technical Information of China (English)

    尹志民; 郭飞跃; 潘青林; 宋练鹏

    2003-01-01

    A kind of Al-Cu-(Sc, Zr, Mn, Ti, V, B) welding wire was developed by adding minor Sc, Zr, Mn, V, B, and was used for welding 2195 aluminum alloy plate with a thickness of 2 mm. Mechanical properties and microstructure of welding wire and welding joint were studied. The results show that strength coefficient of the welding joint is 0.70 and the weakest area lies in the softened zone of HAZ. It is indicated that this welding wire adding minor Sc, Zr, Mn, V, B is an ideal welding wire for 2195 Al-Li alloy plate. The high strength of the weld comes from grain-refining strengthening and precipitation strengthening of Al2Cu, Al3Sc and Al3Zr.

  14. Curriculum (Study Programme) for the M.Sc., Medialogy, at Aalborg University in Copenhagen

    DEFF Research Database (Denmark)

    Serafin, Stefania; Nordahl, Rolf; Lavatino, Salvatore

    2004-01-01

    Defining and describing the education, M.Sc., Medialogy. The curriculum (Study Programme) describes semesters, themes, projectunits, courses and contents of the eduation. offered at Aalborg University in Copenhagen....

  15. DiSC aitab käitumist parandada / Ain Kivesti

    Index Scriptorium Estoniae

    Kivesti, Ain

    2008-01-01

    DiSC testi abil on võimalik saada ülevaade personaalsetest käitumishoiakutest ning vastavalt olukorrale on võimalik harjumuspärast reageerimisstiili radikaalselt muuta. Kommenteerivad Jorma Sarv ja Paavo Pilv

  16. Promising electron mobility and high thermal conductivity in Sc2CT2 (T = F, OH) MXenes

    Science.gov (United States)

    Zha, Xian-Hu; Zhou, Jie; Zhou, Yuhong; Huang, Qing; He, Jian; Francisco, Joseph S.; Luo, Kan; Du, Shiyu

    2016-03-01

    MXenes, the new 2D transition metal carbides and nitrides, have recently attracted extensive attention due to their diverse applications and excellent performances. However, the thermal and electrical properties of most MXene materials are yet to be studied. In this work, we investigate the electrical and thermal properties of semiconducting Sc2CT2 (T = F, OH) MXenes using first-principles calculations. Both of the Sc2CT2 (T = F, OH) MXenes are determined to show excellent carrier mobilities. The electron mobility in the Sc2CF2 MXene is found to be strongly anisotropic at room temperature, with values of 5.03 × 103 and 1.07 × 103 cm2 V-1 s-1 in the zigzag and armchair directions, respectively. The predicted electron mobility in the zigzag direction of the Sc2CF2 is nearly four-fold that in the armchair direction of the promising semiconductor phosphorene. In contrast to Sc2CF2, Sc2C(OH)2 presents approximately isotropic electron mobility. The values at room temperature in the zigzag and armchair directions are calculated as 2.06 × 103 cm2 V-1 s-1 and 2.19 × 103 cm2 V-1 s-1, respectively. In regard to the thermal properties, the thermal conductivities of the Sc2CT2 (T = F, OH) MXenes have been determined. The predicted values are higher than those of most metals and semiconducting low-dimensional materials, such as monolayer MoS2 and phosphorene. In particular, the room-temperature thermal conductivity along the Sc2CF2 armchair direction has been determined to be as high as 472 W m-1 K-1 based on a flake length of 5 μm, which is even higher than that of the best traditional conductor silver. The corresponding value in the zigzag direction of Sc2CF2 is calculated to be 178 W m-1 K-1. The thermal conductivity in Sc2C(OH)2 is less anisotropic and lower compared to that in Sc2CF2. The room-temperature value in the armchair (zigzag) direction is determined to be 173 W m-1 K-1 (107 W m-1 K-1). Based on their excellent electron mobilities and high thermal

  17. 超导ECR离子源DECRIS-SC2%Project of the Superconducting ECR Ion Source DECRIS-SC2

    Institute of Scientific and Technical Information of China (English)

    V.V.Bekhterev; V.V.Seleznev; A.Shishov; G.P.Tsvineva; N.YU.Yazvitsky; B.I.Yakovlev; S.L.Bogomolov; V.I.Datskov; V.M.Drobin; S.N.Dmitriev; A.A.Efremov; V.N.Loginov; A.N.Lebedev; H.Malinowski

    2007-01-01

    A new compact version of the"liquid He-free"superconducting Electron Cyclotron Resonance Ion Source,to be used as an injector for the U-400M cyclotron,is presently under construction at the FLNR in collaboration with LHE(JINR).The axial magnetic field of the source is created by the superconducting magnet,and the NdFeB hexapole is used for the radial plasma confinement.The microwave frequency of 14GHz will be used for ECR plasma heating.The DECRIS-SC2 superconducting magnet is designed for the induction of a magnetic field on the axis of the source of up to 1.4T (extraction side) and 1.9T (injection side) at nominal current of 75A.Cooling of the coils is carried out by GM cryocooler with cooling power of 1W at the temperature 4.5K.The basic design features of the superconducting magnet and of the ion source are presented.The main parts of the source are in production.The first beam test of the source is expected in the beginning of 2007.

  18. Correlative characterization of primary Al{sub 3}(Sc,Zr) phase in an Al–Zn–Mg based alloy

    Energy Technology Data Exchange (ETDEWEB)

    Li, J.H., E-mail: jie-hua.li@hotmail.com [Institute of Casting Research, Montanuniversität Leoben, A-8700 Leoben (Austria); Wiessner, M. [Materials Center Leoben Forschung GmbH, A-8700 Leoben (Austria); Albu, M. [Institute for Electron Microscopy and Nanoanalysis, Graz University of Technology, Center for Electron Microscopy (Austria); Wurster, S. [Department of Materials Physics, Montanuniversität Leoben, Erich Schmid Institute of Materials Science of the Austrian Academy of Sciences, A-8700 Leoben (Austria); Sartory, B. [Materials Center Leoben Forschung GmbH, A-8700 Leoben (Austria); Hofer, F. [Institute for Electron Microscopy and Nanoanalysis, Graz University of Technology, Center for Electron Microscopy (Austria); Schumacher, P. [Institute of Casting Research, Montanuniversität Leoben, A-8700 Leoben (Austria); Austrian Foundry Research Institute, A-8700 Leoben (Austria)

    2015-04-15

    Three-dimensional electron backscatter diffraction, focused ion beam, transmission electron microscopy and energy filtered transmission electron microscopy were employed to investigate the structural information of primary Al{sub 3}(Sc,Zr) phase, i.e. size, shape, element distribution and orientation relationship with the α-Al matrix. It was found that (i) most primary Al{sub 3}(Sc,Zr) phases have a cubic three-dimensional morphology, with a size of about 6–10 μm, (ii) most primary Al{sub 3}(Sc,Zr) phases are located within the α-Al matrix, and exhibit a cube to cube orientation relationship with the α-Al matrix, and (iii) a layer by layer growth was observed within primary Al{sub 3}(Sc,Zr) phases. Al, Cu, Si and Fe are enriched in the α-Al matrix between the layers of cellular eutectic Al{sub 3}(Sc,Zr) phase, while Sc, Ti and Zr are enriched in small Al{sub 3}(Sc,Zr) phases. A peritectic reaction and subsequent eutectic reaction between Al{sub 3}Sc and Al was proposed to interpret the observed layer by layer growth. This paper demonstrates that the presence of impurities (Fe, Si, Cu, Ti) in the diffusion field surrounding the growing Al{sub 3}(Sc,Zr) particle enhances the heterogeneous nucleation of Al{sub 3}(Sc,Zr) phases. - Highlights: • Most fine cubic primary Al{sub 3}(Sc,Zr) phases were observed within the α-Al matrix. • A layer by layer growth within primary Al{sub 3}(Sc,Zr) phase was observed. • A peritectic and subsequent eutectic reaction between Al{sub 3}Sc and Al was proposed. • Impurities in diffusion fields enhance heterogeneous nucleation of Al{sub 3}(Sc,Zr)

  19. Correlative characterization of primary Al3(Sc,Zr) phase in an Al–Zn–Mg based alloy

    International Nuclear Information System (INIS)

    Three-dimensional electron backscatter diffraction, focused ion beam, transmission electron microscopy and energy filtered transmission electron microscopy were employed to investigate the structural information of primary Al3(Sc,Zr) phase, i.e. size, shape, element distribution and orientation relationship with the α-Al matrix. It was found that (i) most primary Al3(Sc,Zr) phases have a cubic three-dimensional morphology, with a size of about 6–10 μm, (ii) most primary Al3(Sc,Zr) phases are located within the α-Al matrix, and exhibit a cube to cube orientation relationship with the α-Al matrix, and (iii) a layer by layer growth was observed within primary Al3(Sc,Zr) phases. Al, Cu, Si and Fe are enriched in the α-Al matrix between the layers of cellular eutectic Al3(Sc,Zr) phase, while Sc, Ti and Zr are enriched in small Al3(Sc,Zr) phases. A peritectic reaction and subsequent eutectic reaction between Al3Sc and Al was proposed to interpret the observed layer by layer growth. This paper demonstrates that the presence of impurities (Fe, Si, Cu, Ti) in the diffusion field surrounding the growing Al3(Sc,Zr) particle enhances the heterogeneous nucleation of Al3(Sc,Zr) phases. - Highlights: • Most fine cubic primary Al3(Sc,Zr) phases were observed within the α-Al matrix. • A layer by layer growth within primary Al3(Sc,Zr) phase was observed. • A peritectic and subsequent eutectic reaction between Al3Sc and Al was proposed. • Impurities in diffusion fields enhance heterogeneous nucleation of Al3(Sc,Zr)

  20. A Top-Down Optimization Methodology for SC Filter Circuit Design Using Varying Goal Specifications

    OpenAIRE

    Serra, Hugo; Santos-Tavares, Rui; Paulino, Nuno

    2014-01-01

    Part 19: Electronics: Design International audience The design of Switched-Capacitor (SC) filters can be an arduous process, which becomes even more complex when the high gain amplifier is replaced by a low gain amplifier or a voltage follower. This eliminates the virtual ground node, requiring the compensation of the parasitic capacitances during the design phase. This paper proposes an automatic procedure for the design of SC filters using low gain amplifiers, based on a Genetic Algor...

  1. Effects of geometric and material parameters on failure modes of SC elements

    OpenAIRE

    Lohani, Vishesh

    2016-01-01

    A steel-concrete-steel composite (SC) element resembles double skin sandwich composite structure in which the concrete core is in-filled between steel skins. Mechanical shear connectors connect the skins and they are embedded in concrete. These connectors transfer shear forces and have an important role in performance of composite element. SC element is prone to different failure modes such as flexural failure, de-bonding between steel plate and concrete, and shear failure. There are 3 aims o...

  2. Influence of Sc on high temperature strengthening behavior of Ti-6Al-4V alloy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Vacuum arc melting technique was used to prepare Ti-6Al-4V alloy containing Sc (0.3% and 0.5%, mass fraction). The ingots were melted twice by vacuum self-consumable electrode arc furnace. Forging of ingots was started in β-phase region and finished in high (α+β)-phase region. Annealing after forging was performed in low (α+β)-phase region for 30 min. Isothermal high temperature compression tests were conducted using thermal simulation machine under Ar atmosphere at 850 ℃ and 1 000 ℃, and the strain rate were 0.001, 0.01, 0.1 and 1.0 s-1. Optical microscope(OM), scanning electron microscopy(SEM), energy dispersive spectrum(EDS) and transmission electron microscope(TEM) were used to study the microstructure evolution during high temperature deformation. The results show that, the peak stress value of alloys increases with increasing Sc content after deformation at 850 ℃,however, there is no obvious strengthening of Sc when the alloys are deformed at 1 000 ℃. Sc exists as Sc2O3 forms by internal oxidation during forging procedure, only minor Sc solutes in matrix. At 850 ℃, the interaction between dislocation and participated particles and twinning mechanism controls the deformation procedure accompanied recrystallization. At 1 000 ℃, the deformation of alloys containing Sc is mainly controlled by twinning, while the deformation of alloy without Sc is not only controlled by twinning,but also the interaction between dislocation and precipitated particles inside the twinning lamellar.

  3. Magnetic dipole moment of the doubly closed-shell plus one proton nucleus $^{49}$Sc

    CERN Multimedia

    Gaulard, C V; Walters, W; Nishimura, K; Muto, S; Bingham, C R

    It is proposed to measure the magnetic moment of $^{49}$Sc by the Nuclear Magnetic Resonance on Oriented Nuclei (NMR-ON) method using the NICOLE on-line nuclear orientation facility. $^{49}$Sc is the neutron rich, doubly closed-shell, nucleus $^{48}$Ca plus one proton. Results will be used to deduce the effective g-factors in the $^{48}$Ca region with reference to nuclear structure and meson exchange current effects.

  4. Complete Genome Sequence of Highly Virulent Haemophilus parasuis Serotype 11 Strain SC1401

    Science.gov (United States)

    Dai, Ke; Jin, Jin; Wen, Xintian; He, Lvqin; Cao, Sanjie; Huang, Xiaobo; Wu, Rui; Zhao, Qin

    2016-01-01

    Haemophilus parasuis, a normal Gram-negative bacterium, may cause Glässer’s disease and pneumonia in pigs. This study aims to identify the genes related to natural competence of the serotype 11 strain SC1401, which frequently shows competence and high pathogenicity. SC1401 shows many differences from strains without natural competence within the molecular basis. We performed complete genome sequencing together with restriction modification system analysis to lay the foundation for later study. PMID:27445368

  5. CMS ECAL Endcap (EE) Dee Assembly - SC mounting on Dee 1

    CERN Multimedia

    Cockerill, D

    2007-01-01

    Protection panels on back of Dee 1, Completion of SC mounting, 03/10/2007: Completion of SC mounting (aart from the inner 3-2-1)on the first quadrant of Dee 1 and subsequent survey. 22-28/08/2007: The first supercrystals on Dee1, Dee1 in 867 with the first column of SCs ready for mounting, Dee1 with its protection panels over the laser monitoring fibre system

  6. Early Stages of Precipitation Process in Al-(Mn-)Sc-Zr Alloy Characterized by Positron Annihilation

    KAUST Repository

    Vlach, Martin

    2015-01-29

    Thermal effects on the precipitation stages in as-cast Al-0.70 at. pct Mn-0.15 at. pct Sc-0.05 at. pct Zr alloy were studied. The role of lattice defects was elucidated by positron annihilation spectroscopy (lifetime and coincidence Doppler broadening) enabling investigation of solutes clustering at the atomic scale. This technique has never been used in the Al-Sc- and/or Al-Zr-based alloys so far. Studies by positron annihilation were combined with resistometry, hardness measurements, and microstructure observations. Positrons trapped at defects are preferentially annihilated by Sc electrons. Lifetime of trapped positrons indicates that Sc atoms segregate at dislocations. Maximum fraction of positrons annihilated by Sc electrons occurring at 453 K (180 °C) suggests that clustering of Sc bound with vacancies takes place. It is followed by peak of this fraction at 573 K (300 °C). A rise of the contribution of trapped positrons annihilated by Zr electrons starting at 513 K (240 °C) and attaining maximum also at 573 K (300 °C) confirms that Zr participates in precipitation of the Al3Sc particles already at these temperatures. The pronounced hardening at 573 K (300 °C) has its nature in the precipitation of the Al3Sc particles with a Zr-rich shell. The contribution of trapped positrons annihilated by Mn electrons was found to be negligible. © 2015, The Minerals, Metals & Materials Society and ASM International.

  7. Strategisk anarki : en utredning av WeActivists strategiska funktion inom WeSC

    OpenAIRE

    Leijonborg, Lindström, Frida, Nils

    2013-01-01

    ABSTRACT Title: Strategic Anarchy – a study on WeActivists' communicative function inside WeSC. Number of pages: 69 Authors: Frida Leijonborg, Nils Lindström Tutor: Jessica Gustafsson Course: Media and communication studies C Period: Second term 2013 University: Division of Media and Communication, department of information science, Uppsala University Purpose: Our aim with this paper is to examine the communicative role WeActivists play in WeSC's external communication, and also to investiga...

  8. EngenuitySC Commercialization and Entrepreneurial Training Project

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Meghan; Hutton, Katherine R

    2012-12-31

    A team led by EngenuitySC has performed education and outreach on development of advanced energy markets that will enable wider use of clean energy technologies. This report details the efforts that have made significant advances to improve the market place through education, outreach, and increased communications between industry members. The project resulted in two self-funded industry clusters known as the Fuel Cell Collaborative and NuHub. This project has focused on building and strengthening the leading clean energy clusters in South Carolina: nuclear energy and fuel cell technologies. For the nuclear industry, a new cluster was developed that is now known as NuHub. This cluster has already engaged over 25 nuclear industry leaders or suppliers, four public sector partners, six community economic development foundations, and nearly ten academic partners in a 175 mile radius between Augusta, Georgia and Charlotte, North Carolina. Our outreach has touched over 2,000 stakeholders through the website alone, not including the public audiences and members of the business community reached through news stories and releases that were distributed to over 620 print and online publications. NuHub has established a formal leadership structure, developed subcommittees to focus on industry issues, instituted educational programs for the workforce, and created an industry funding structure that will sustain the industry cluster and mission. NuHub has participated in a wide-variety of community building and outreach activities since its formation under this grant. In the two years since its creation in 2010, we have initiated efforts focused in four main areas that correlate with the four NuHub subcommittees including: innovation, workforce development, industry engagement, and marketing and communications. NuHub successfully raised over $160,000 in both public and private funding, which has supported work to grow the cluster and engage partners including NuScale, Fluor, and

  9. Authenticated, private, and secured smart cards (APS-SC)

    Science.gov (United States)

    Szu, Harold; Mehmood, Amir

    2006-04-01

    From historical perspective, the recent advancements in better antenna designs, low power circuitry integrations and inexpensive fabrication materials have made possible a miniature counter-measure against Radar, a clutter behaving like a fake target return called Digital Reflection Frequency Modulation (DRFM). Such a military counter-measure have found its way in the commerce as a near field communication known as Radio Frequency Identification (RFID), a passive or active item tag T attached to every readable-writable Smart Card (SC): Passports ID, medical patient ID, biometric ID, driver licenses, book ID, library ID, etc. These avalanche phenomena may be due to the 3 rd Gen phones seeking much more versatile & inexpensive interfaces, than the line-of-sight bar-code optical scan. Despite of the popularity of RFID, the lacking of Authenticity, Privacy and Security (APS) protection restricted somewhat the wide spread commercial, financial, medical, legal, and militarily applications. Conventional APS approach can obfuscate a private passkey K of SC with the tag number T or the reader number R, or both, i.e. only T*K or R*K or both will appear on them, where * denotes an invertible operation, e.g. EXOR, but not limited to it. Then, only the authentic owner, knowing all, can inverse the operation, e.g. EXOR*EXOR= I to find K. However, such an encryption could be easily compromised by a hacker seeking exhaustively by comparison based on those frequently used words. Nevertheless, knowing biological wetware lesson for power of pairs sensors and Radar hardware counter-measure history, we can counter the counter-measure DRFM, instead using one RFID tag per SD, we follow the Nature adopting two ears/tags, e.g. each one holding portions of the ID or simply two different ID's readable only by different modes of the interrogating reader, followed by brain central processor in terms of nonlinear invertible shufflers mixing two ID bits. We prefer to adopt such a hardware

  10. A blue-emitting Sc silicate phosphor for ultraviolet excited light-emitting diodes.

    Science.gov (United States)

    Wang, Qian; Zhu, Ge; Xin, Shuangyu; Ding, Xin; Xu, Ju; Wang, Yuansheng; Wang, Yuhua

    2015-11-01

    A blue-emitting phosphor BaSc2Si3O10:Eu(2+) was synthesized using the conventional solid-state reaction. The crystallographic occupancy of Eu(2+) in the BaSc2Si3O10 matrix was studied based on the Rietveld refinement results and the photoluminescence properties. BaSc2Si3O10 exhibits blue emission ascribed to (3)T2-(1)A1 and (3)T1-(1)A1 charge transfer of SiO4(4-) excited by 360 nm. All the phosphors of BaSc2Si3O10:Eu(2+) exhibit strong broad absorption bands in the near ultraviolet range, and give abnormal blue emission upon 330 nm excitation. The abnormal phenomenon was explored in detail through many pieces of experimental evidence. The concentration of Eu(2+) is optimized to be 3 mol% according to emission intensity and the quenching mechanism is verified to be a quadrupole-quadrupole interaction. The CIE coordinates of BaSc2Si3O10:0.03Eu(2+) are calculated to be (0.15, 0.05) and BaSc2Si3O10:0.03Eu(2+) shows similar thermal stability to commercial BaMgAl10O17:Eu(2+). PMID:26242881

  11. Corrosion behavior of an Al-6Mg-Sc-Zr alloy

    Institute of Scientific and Technical Information of China (English)

    XU Guangxing; TAO Binwu; LIU Jianhua; LI Songmei

    2005-01-01

    The corrosion behavior of an Al-6Mg-Sc-Zr alloy was studied and compared with that of an Al-6Mg-Zr alloy.The addition of scandium into the Al-6Mg-Zr alloy reduced the susceptibility to exfoliation corrosion. By using the constant load tensile method in a 3.5 wt.% NaCl solution, the resistance to SCC of the Al-6Mg-Sc-Zr alloy was higher than that of the Al-6Mg-Zr alloy. When the specimens were not applied with an anodic current, the Al-6Mg-Sc-Zr alloy was resistance to SCC and no brittle cracking was found on the fracture surface. When an anodic current was applied, the Al-6Mg-Sc-Zr alloy specimens failed as a result of accelerated corrosion rather than SCC. It was believed that the addition of scandium resulted in (Al3Sc, Zr) particles that greatly refmed grains and promoted the formation of homogeneous discontinuous distribution of β-phase in the alloy base, which much contributed to good corrosion resistance of the Al-6Mg-Sc-Zr alloy.

  12. Detergents modify proteinase K resistance of PrP Sc in different transmissible spongiform encephalopathies (TSEs).

    Science.gov (United States)

    Breyer, Johanna; Wemheuer, Wiebke M; Wrede, Arne; Graham, Catherine; Benestad, Sylvie L; Brenig, Bertram; Richt, Jürgen A; Schulz-Schaeffer, Walter J

    2012-05-25

    Prion diseases are diagnosed by the detection of their proteinase K-resistant prion protein fragment (PrP(Sc)). Various biochemical protocols use different detergents for the tissue preparation. We found that the resistance of PrP(Sc) against proteinase K may vary strongly with the detergent used. In our study, we investigated the influence of the most commonly used detergents on eight different TSE agents derived from different species and distinct prion disease forms. For a high throughput we used a membrane adsorption assay to detect small amounts of prion aggregates, as well as Western blotting. Tissue lysates were prepared using DOC, SLS, SDS or Triton X-100 in different concentrations and these were digested with various amounts of proteinase K. Detergents are able to enhance or diminish the detectability of PrP(Sc) after proteinase K digestion. Depending on the kind of detergent, its concentration - but also on the host species that developed the TSE and the disease form or prion type - the detectability of PrP(Sc) can be very different. The results obtained here may be helpful during the development or improvement of a PrP(Sc) detection method and they point towards a detergent effect that can be additionally used for decontamination purposes. A plausible explanation for the detergent effects described in this article could be an interaction with the lipids associated with PrP(Sc) that may stabilize the aggregates.

  13. Structural, electronic and elastic properties of M2SC (M = Ti, Zr, Hf) compounds

    International Nuclear Information System (INIS)

    Using ab initio calculations, we have studied the structural, electronic and elastic properties of M2SC, with M = Ti, Zr and Hf. Geometrical optimization of the unit cell are in good agreement with the available experimental data. The band structures show that all three materials are conducting. The analysis of the site and momentum projected densities shows that the bonding is achieved through a hybridization of M-atom d states with S and C-atom p states. The Md-Sp bonds are lower in energy and are stiffer than Md-Cp bonds. The elastic constants are calculated using the static finite strain technique. We derived the bulk and shear moduli, Young's moduli and Poisson's ratio for ideal polycrystalline M2SC aggregates. We estimated the Debye temperature of M2SC from the average sound velocity. This is a quantitative theoretical prediction of the elastic properties of Ti2SC, Zr2SC, and Hf2SC compounds, and it still awaits experimental confirmation

  14. Conceptual Design of the TPF-O SC Bus

    Science.gov (United States)

    Purves, Lloyd R.

    2007-01-01

    One option under current study for the Terrestrial Planet Finder-Occulter (TPF-O) observatory shares some key features of the Hubble Space Telescope (HST). Both are space telescopes with a primary mirror aperture of around 2.4 meters and designed to observe in the visible to near infrared range of wavelengths, with the major difference in science capability being that TPF-O has an areal FOV on the order of 100 times larger than that of HST. This larger FOV, whose science camera is also expected to provide fine guidance, and other mission differences, mean that most TPF-O SC bus subsystems will have very different requirements than those of HST. Unlike HST in LEO, TPF-O is designed to operate in an orbit around the Sun-Earth lagrange 2 (SEL2) point. The longer communications range to SEL2 and the large FOV require much higher performance data processing and communications than HST. Maintaining a SEL2 orbit requires TPF-O, unlike HST, to have a propulsion system. TPF-O will have a specialized tracking system that allows the formation flying occulter to maintain its required position. However, despite these additional features, the velocity required for reaching SEL2 and the limited capabilities of affordable launch vehicles require TPF-O to have a compact and low-mass design relative to HST. Finally, TPF-O may utilize a modular design to reduce development cost and, if it required, allow servicing using approaches different from those of HST.

  15. One-neutron knockout from {sup 51-55}Sc

    Energy Technology Data Exchange (ETDEWEB)

    Schwertel, S.; Maierbeck, P.; Gernhaeuser, R.; Bildstein, V.; Boehmer, M.; Eppinger, K.; Faestermann, T.; Friese, J.; Fabbietti, L.; Maier, L.; Winkler, S. [Technische Universitaet Muenchen, Physik Department E12, Garching (Germany); Kruecken, R. [Technische Universitaet Muenchen, Physik Department E12, Garching (Germany); TRIUMF, Vancouver (Canada); University of British Columbia, Department of Physics and Astronomy, Vancouver (Canada); Kroell, T. [Technische Universitaet Muenchen, Physik Department E12, Garching (Germany); Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Alvarez-Pol, H.; Benjamim, E.A.; Benlliure, J.; Caamano, M.; Cortina-Gil, D.; Gascon, M.; Kurtukian, T.; Perez, D.; Rodriguez-Tajes, C. [Universidade de Santiago de Compostela, Departamento de Fisica de Particulas, Santiago de Compostela (Spain); Aksouh, F.; Aumann, T.; Behr, K.; Boretzky, K.; Bruenle, A.; Chatillon, A.; Chulkov, L.V.; Geissel, H.; Gerl, J.; Gorska, M.; Kojouharov, I.; Klimkiewicz, A.; Kurz, N.; Nociforo, C.; Schaffner, H.; Simon, H.; Stanoiu, M.; Suemmerer, K.; Weick, H. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Borge, M.J.G.; Pascual-Izarra, C.; Perea, A.; Tengblad, O. [CSIC, Instituto de Estructura de la Materia, Madrid (Spain); Buerger, A. [University of Oslo, SAFE/OCL, Oslo (Norway); CEA, Gif-sur-Yvette (France); Casarejos, E.; Brown, B.A. [University of Vigo, Vigo (Spain); Enders, J.; Schrieder, G. [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Hansen, P.G. [Michigan State University, NSCL, East Lansing, Michigan (United States); Jonson, B.; Nyman, G. [Chalmers Tekniska Hoegskola och Goeteborgs Universitet, Experimentell Fysik, Goeteborg (Sweden); Kanungo, R. [TRIUMF, Vancouver (Canada); GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Saint Mary' s University, Halifax (Canada); Kiselev, O. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Johannes Gutenberg Universitaet, Mainz (Germany); Paul Scherrer Institut, Villigen (Switzerland); Larsson, K. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Chalmers Tekniska Hoegskola och Goeteborgs Universitet, Experimentell Fysik, Goeteborg (Sweden); Le Bleis, T. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); IN2P3-CNRS/Universite Louis Pasteur, Institut Pluridisciplinaire Hubert Curien, Strasbourg Cedex 2 (France); Mahata, K. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Paul Scherrer Institut, Villigen (Switzerland); Nilsson, T. [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Chalmers Tekniska Hoegskola och Goeteborgs Universitet, Experimentell Fysik, Goeteborg (Sweden); Prochazka, A. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Comenius University, Faculty of Mathematics and Physics, Bratislava (Slovakia); Rossi, D. [Johannes Gutenberg Universitaet, Mainz (Germany); Sitar, B. [Comenius University, Faculty of Mathematics and Physics, Bratislava (Slovakia); Otsuka, T. [University of Tokyo, Hongo, Bunkyo-ku, Department of Physics, Tokyo (Japan); Tostevin, J.A. [University of Surrey, Department of Physics, Faculty of Engineering and Physical Sciences, Guildford (United Kingdom); Rae, W.D.M. [Garsington, Oxfordshire (United Kingdom)

    2012-12-15

    Results are presented from a one-neutron knockout experiment at relativistic energies of {approx} 420 A MeV on {sup 51-55}Sc using the GSI Fragment Separator as a two-stage magnetic spectrometer and the MINIBALL array for gamma-ray detection. Inclusive longitudinal momentum distributions and cross-sections were measured enabling the determination of the contributions corresponding to knockout from the {nu}p{sub 1/2}, {nu}p{sub 3/2}, (L = 1) and {nu}f{sub 7/2}, {nu}f{sub 5/2} (L = 3) neutron orbitals. The observed L = 1 and L = 3 contributions are compared with theoretical cross-sections using eikonal knockout theory and spectroscopic factors from shell model calculations using the GXPF1A interaction. The measured inclusive knockout cross-sections generally follow the trends expected theoretically and given by the spectroscopic strength predicted from the shell model calculations. However, the deduced L = 1 cross-sections are generally 30-40% higher while the L = 3 contributions are about a factor of two smaller than predicted. This points to a promotion of neutrons from the {nu}f{sub 7/2} to the {nu}p{sub 3/2} orbital indicating a weakening of the N = 28 shell gap in these nuclei. While this is not predicted for the phenomenological GXPF1A interaction such a weakening is predicted by recent calculations using realistic low-momentum interactions V{sub low} {sub k} obtained by evolving a chiral N3LO nucleon-nucleon potential. (orig.)

  16. Two-gap superconductivity in R2Fe3Si5 (R=Lu, Sc and Sc5Ir4Si10

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Tamegai, Yasuyuki Nakajima, Tsuyoshi Nakagawa, Guoji Li and Hisatomo Harima

    2008-01-01

    Full Text Available R2Fe3Si5 (R= Sc, Y, Lu contains nonmagnetic iron and has a relatively high superconducting transition temperature Tc among iron-containing superconductors. An anomalous temperature dependence of specific heat C(T has been reported for polycrystalline samples down to 1 K. We have grown R2Fe3Si5 single crystals, confirmed the anomalous C(T dependence, and found a second drop in specific heat below 1 K. In Lu2Fe3Si5, we can reproduce C(T below Tc, assuming two distinct energy gaps 2Δ 1/kBTc = 4.4 and 2Δ 2/kBTc = 1.1, with nearly equal weights, indicating that Lu2Fe3Si5 is a two-gap superconductor similar to MgB2. Hall coefficient measurements and band structure calculation also support the multiband contributions to the normal-state properties. The specific heat in the Sc2Fe3Si5 single crystals also shows the two-gap feature. R5Ir4Si10 (R = Sc, rare earth is also a superconductor where competition between superconductivity and the charge-density wave is known for rare earths but not for Sc. We have performed detailed specific heat measurements on Sc5Ir4Si10 single crystals and found that C(T deviates slightly from the behavior expected for weak-coupling superconductors. C(T for these superconductors can also be reproduced well by assuming two superconducting gaps.

  17. Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

    International Nuclear Information System (INIS)

    CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance

  18. Low Temperature Synthesis and Characterization of AlScMo3O12

    Directory of Open Access Journals (Sweden)

    Rebecca Truitt

    2015-02-01

    Full Text Available Recent interest in low and negative thermal expansion materials has led to significant research on compounds that exhibit this property, much of which has targeted the A2M3O12 family (A = trivalent cation, M = Mo, W. The expansion and phase transition behavior in this family can be tuned through the choice of the metals incorporated into the structure. An undesired phase transition to a monoclinic structure with large positive expansion can be suppressed in some solid solutions by substituting the A-site by a mixture of two cations. One such material, AlScMo3O12, was successfully synthesized using non-hydrolytic sol-gel chemistry. Depending on the reaction conditions, phase separation into Al2Mo3O12 and Sc2Mo3O12 or single-phase AlScMo3O12 could be obtained. Optimized conditions for the reproducible synthesis of stoichiometric, homogeneous AlScMo3O12 were established. High resolution synchrotron diffraction experiments were carried out to confirm whether samples were homogeneous and to estimate the Al:Sc ratio through Rietveld refinement and Vegard’s law. Single-phase samples were found to adopt the orthorhombic Sc2W3O12 structure at 100 to 460 K. In contrast to all previously-reported A2M3O12 compositions, AlScMo3O12 exhibited positive thermal expansion along all unit cell axes instead of contraction along one or two axes, with expansion coefficients (200–460 K of αa = 1.7 × 10−6 K−1, αb = 6.2 × 10−6 K−1, αc = 2.9 × 10−6 K−1 and αV = 10.8 × 10−6 K−1, respectively.

  19. The inhibition of lung cancer cell growth by intracellular immunization with LC-1 ScFv

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A monoclonal antibody, LC-l, recognizing lung cancer associated common antigens was obtained in authors' laboratory. Its single chain Fv fragment (ScFv) named LC-1 ScFv was constructed based on recombinant phage displayed techniques. For expression on cell membrane, LC-1 ScFv was cloned into pDisplay vector, which directed the cloned gene to express as cell membrane bound protein. The resulting plasmid was sequenced and then introduced by the lipofectin method into a lung adenocarcinoma cell line SPC-A-1. G418 resistant cells were obtained by G418 selection. After transfection, LC-1 ScFv expression was observed by Western blot analysis and the expression of cognate antigens was down-regulated as shown in ELISA assay. SPC-A-1-pDisplay-ScFv cells grew in vitro at lower speed than the control intact cells and the cells transfected with vacant vector. Flow cytometry analysis detected a substantial increase in G1 phase and decrease in S phase in population of SPC-A-1-pDisplay-ScFv cells compared to SPC-A-1 and SPC-A1-pDisplay cells. Semi-quantitative RT-PCR analysis showed that c-myc expression was down-regulated in SPC-A-1-pDisplay-ScFv cells. It seems that the antigens recognized by LC-1 may be in some way involved in a growth stimulating pathway and the antibody blocking of the function of the antigens shut down the pathway and thus down-regulate the expression of c-myc and growth of the cells.

  20. A Global Record of Surface Earth Oxygenation from Sedimentary V/Sc

    Science.gov (United States)

    Keller, C. B.; Schoene, B.; Johnston, D. T.

    2015-12-01

    One of the simplest methods to investigate changes in oxidation potential in geologic environments is to examine a pair of otherwise similar elements with dramatically different redox chemistry. The first-row transition metals Sc and V represent one such pair, with generally similar mass, radius, and ionization energies up to the trivalent redox state. However, as a d3 transition metal, Sc is limited to a maximum oxidation state of 3+, while d5 vanadium may be further oxidized to form tetravalent and pentavalent ions. Due to the greater incompatibility of pentavalent (relative to trivalent) metal cations in silicate melts, V/Sc ratio has been applied to the silicate rock record as a tracer of magma redox - indicating roughly constant mantle oxygen fugacity over Earth history1,2. As a result, the solid earth represents a boundary condition with constant V/Sc observed over geologic time1. However, oxidation state also affects the weathering, solubility, and coordination behaviour of V and Sc, resulting in a potential redox signal in the sedimentary V/Sc record. We apply the weighted bootstrap resampling approach of [2] to a geochemical dataset of ~87,000 sedimentary whole-rock analyses from the EarthChem portal3. The resulting trends reveal a 4 Gyr record of V/Sc redox chemistry, with the great oxidation event represented as an upward step ca. 2.5 Ga, and Phanerozoic variation suggestive of low oxygen in the early Paleozoic, increasing to twin maxima circa 270 Ma and 130 Ma, remarkably similar to that predicted by the COPSE model4, and broadly congruent with the Phanerozoic biochar record5. Li, Z.-X. A. & Lee, C.-T. A. EPSL 228, 483-493 (2004). Keller, C. B. & Schoene, B. Nature 485, 490-493 (2012). EarthChem Bergman, N. M. Am. J. Science 304, 397-437 (2004). Glasspool, I. J. & Scott, A. C. Nat. Geosci. 3, 627-630 (2010).

  1. Phase relations of Al-4Mg-Sc-Zr quaternary system in Al-rich range at 430 ℃

    Institute of Scientific and Technical Information of China (English)

    夏长清; 曾凡浩; 古一

    2003-01-01

    The 430 ℃ isothermal section of the Al-4Mg-Sc-Zr quaternary system in the Al-rich range was determined by means of equilibrium alloys with the use of microstructure, X-ray diffraction analysis and electron probe microanalysis. There coexist three single-phase fields, two two-phase fields and one three-phase field. It is established that the phase Al3Sc1-0.5Zr0-0.5 with L12 structure and Al3Zr1-0.8Sc0-0.2 with DO23 structure are in equilibrium with the α solid solution, Zr being dissolved in Al3Sc, further substituting for about 50% Sc(mole fraction) whilst Sc is present in the phase Al3Zr and the maximum substitution for Zr is about 20%.

  2. Conductivity ageing studies on 1M10ScSZ (M4+=Ce, Hf)

    DEFF Research Database (Denmark)

    Omar, Shobit; Bin Najib, Waqas; Bonanos, Nikolaos

    2011-01-01

    The long-term conductivity stability is tested on zirconia based electrolyte materials for solid oxide fuel cell applications. The ageing studies have been performed on the samples of ZrO2 co-doped with 10mol% of Sc2O3 and 1mol% MO2, where M = Ce or Hf (denoted respectively 1Ce10ScSZ and 1Hf10Sc......SZ) in oxidising and reducing atmospheres, at 600°C for 3000h. At 600°C, these compositions show initial conductivity of around 9–12mS∙cm−1 in air. After 3000h of ageing, no phase transitions are observed in any of the samples. For the first 1000h, the degradation rate is higher than in the subsequent 2000h......; thereafter, conductivity degrades linearly with time for all samples. In air, the loss in the conductivity is lower than in reducing conditions. The 1Ce10ScSZ shows the highest degradation rate of 3.8%/1000h in wet H2/N2 after the first 1000h of ageing. A colour change of the 1Ce10ScSZ sample from white...

  3. Unexpected magnetic behavior in amorphous Co{sub 90}Sc{sub 10} alloy

    Energy Technology Data Exchange (ETDEWEB)

    Ghafari, M., E-mail: mohammad.ghafari@kit.edu, E-mail: skamali@utsi.edu; Gleiter, H. [Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing 210094 (China); Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany); Sakurai, Y.; Itou, M. [Japan Synchrotron Radiation Research Institute (JASRI), SPring-8, 1-1-1 Kouto, Sayo, Sayo, Hyogo (Japan); Peng, G.; Fang, Y. N.; Feng, T. [Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing 210094 (China); Hahn, H. [Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing 210094 (China); Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany); KIT-TUD Joint Research Laboratory Nanomaterials, Institute of Materials Science, Technische Universität Darmstadt (TUD), Jovanka-Bontschits-Str. 2, 64287 Darmstadt (Germany); Kamali, S., E-mail: mohammad.ghafari@kit.edu, E-mail: skamali@utsi.edu [Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee Space Institute, Tullahoma, Tennessee 37388 (United States)

    2015-09-28

    An amorphous alloy Co{sub 90}Sc{sub 10} has been prepared by rapid quenching from the melt. The results of magnetization measurements show that this alloy has the highest Curie temperature reported for any amorphous transition metal based alloys. Furthermore, for a Co based amorphous alloy, the magnetic moment is remarkably high. Moreover, the alloy exhibits soft magnetic properties. Based on the findings, amorphous Co{sub 90}Sc{sub 10} appears to be an attractive candidate for applications as a soft magnetic material. The temperature dependence of the reduced magnetization can be described by the Bloch power law. The results show that the B coefficient of the amorphous Co{sub 90}Sc{sub 10} alloy, which is a measure of the rigidity of spin waves, exhibits the lowest value observed until now for any amorphous alloy and is comparable to crystalline alloys. It is found that the Sc atoms in the Co{sub 90}Sc{sub 10} alloy lead to an increase of the itinerant spin moment of Co atoms, and, in contrast to this behaviour, to a decrease of the local 3d-electrons of Co.

  4. Fast conversion of scFv to Fab antibodies using type IIs restriction enzymes.

    Science.gov (United States)

    Sanmark, Hanna; Huovinen, Tuomas; Matikka, Tero; Pettersson, Tiina; Lahti, Maria; Lamminmäki, Urpo

    2015-11-01

    Single chain variable fragment (scFv) antibody libraries are widely used for developing novel bioaffinity reagents, although Fab or IgG molecules are the preferred antibody formats in many final applications. Therefore, rapid conversion methods for combining multiple DNA fragments are needed to attach constant domains to the scFv derived variable domains. In this study we describe a fast and easy cloning method for the conversion of single framework scFv fragments to Fab fragments using type IIS restriction enzymes. All cloning steps excluding plating of the Fab transformants can be done in 96 well plates and the procedure can be completed in one working day. The concept was tested by converting 69 scFv clones into Fab format on 96 well plates, which resulted in 93% success rate. The method is particularly useful as a high-throughput tool for the conversion of the chosen scFv clones into Fab molecules in order to analyze them as early as possible, as the conversion can significantly affect the binding properties of the chosen clones.

  5. Microstructure dependent fatigue crack growth in Al–Mg–Sc alloy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Mengjia [School of Materials Science and Engineering, Central South University, Changsha 410083 (China); Pan, Qinglin, E-mail: csupql@163.com [The Key Laboratory of Nonferrous Materials Science and Engineering of Ministry of Education, Central South University, Changsha 410083 (China); Shi, Yunjia; Wang, Ying [School of Materials Science and Engineering, Central South University, Changsha 410083 (China)

    2014-08-12

    The fatigue crack growth behavior of Al–Mg–Sc alloy was investigated by tensile testing and fatigue testing. Different annealing treatments were applied to the alloy. Microstructure characterization of the alloy was carried out by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and optical microscopy (OM). The size of Al{sub 3}(Sc{sub 1−x}Zr{sub x}) particle was calculated by software. The fatigue crack growth (FCG) rate (da/dN) was discussed with stress intensity factor range (ΔK) in Paris's region. The Paris exponent m and constants C were used to calculate the fatigue life. The fatigue process and crack closure effects were discussed with the yield strength and tensile strength of Al–Mg–Sc alloy. Results show that the microstructure, tensile strength and fatigue crack growth rate were greatly dependent on the annealing temperature, and the high resistance of Al–Mg–Sc alloy was mainly due to the combination microstructures of sub-grains, dislocations and these Al{sub 3}(Sc{sub 1−x}Zr{sub x}) precipitates.

  6. Isolation of anti-T cell receptor scFv mutants by yeast surface display.

    Science.gov (United States)

    Kieke, M C; Cho, B K; Boder, E T; Kranz, D M; Wittrup, K D

    1997-11-01

    Yeast surface display and sorting by flow cytometry have been used to isolate mutants of an scFv that is specific for the Vbeta8 region of the T cell receptor. Selection was based on equilibrium binding by two fluorescently labeled probes, a soluble Vbeta8 domain and an antibody to the c-myc epitope tag present at the carboxy-terminus of the scFv. The mutants that were selected in this screen included a scFv with threefold increased affinity for the Vbeta8 and scFv clones that were bound with reduced affinities by the anti-c-myc antibody. The latter finding indicates that the yeast display system may be used to map conformational epitopes, which cannot be revealed by standard peptide screens. Equilibrium antigen binding constants were estimated within the surface display format, allowing screening of isolated mutants without necessitating subcloning and soluble expression. Only a relatively small library of yeast cells (3 x 10[5]) displaying randomly mutagenized scFv was screened to identify these mutants, indicating that this system will provide a powerful tool for engineering the binding properties of eucaryotic secreted and cell surface proteins.

  7. Spinal Cord Infarction in Hemoglobin SC Disease as an Amusement Park Accident.

    Science.gov (United States)

    Eid, Ryan; Raj, Ashok; Farber, Darren; Puri, Vinay; Bertolone, Salvatore

    2016-09-01

    Spinal cord infarction (SCI) is extremely rare in children, and only 2 other reports have described the occurrence of SCI in patients with hemoglobin SC disease (HbSC). Amusement park accidents are serious injuries. Patients with preexisting conditions, such as hypertension, cardiac disease, and recent back or neck injuries, may be at an increased risk. We report the case of a 12-year-old girl with HbSC with a past history of only 2 admissions for pain crises, who presented to the emergency department with symptoms of SCI after riding a roller coaster. Fibrocartilaginous embolism (FCE) is an increasingly recognized cause of SCI after events that put strain on the axial skeleton, such as many amusement park rides. Although radiologic criteria for FCE have been proposed, FCE remains a diagnosis of exclusion. To the best of our knowledge, this is the first documented case of SCI in a patient with HbSC and the first case of FCE after an amusement park accident. This case report highlights that HbSC may confound the differential diagnosis of SCI and aims to document an association with FCE in pediatric patients. PMID:27485695

  8. Spinal Cord Infarction in Hemoglobin SC Disease as an Amusement Park Accident.

    Science.gov (United States)

    Eid, Ryan; Raj, Ashok; Farber, Darren; Puri, Vinay; Bertolone, Salvatore

    2016-09-01

    Spinal cord infarction (SCI) is extremely rare in children, and only 2 other reports have described the occurrence of SCI in patients with hemoglobin SC disease (HbSC). Amusement park accidents are serious injuries. Patients with preexisting conditions, such as hypertension, cardiac disease, and recent back or neck injuries, may be at an increased risk. We report the case of a 12-year-old girl with HbSC with a past history of only 2 admissions for pain crises, who presented to the emergency department with symptoms of SCI after riding a roller coaster. Fibrocartilaginous embolism (FCE) is an increasingly recognized cause of SCI after events that put strain on the axial skeleton, such as many amusement park rides. Although radiologic criteria for FCE have been proposed, FCE remains a diagnosis of exclusion. To the best of our knowledge, this is the first documented case of SCI in a patient with HbSC and the first case of FCE after an amusement park accident. This case report highlights that HbSC may confound the differential diagnosis of SCI and aims to document an association with FCE in pediatric patients.

  9. Construction of Human ScFv Phage Display Library against Ovarian Tumor

    Institute of Scientific and Technical Information of China (English)

    XIA Jinsong; BI Hao; YAO Qin; QU Shen; ZONG Yiqiang

    2006-01-01

    In order to construct a single chain fragment variable (ScFv) phage display library against ovarian tumor, by using RT-PCR, the human heavy chain variable region genes (VH) and light chain variable region genes (VL) were amplified from lymphocytes of ovarian tumor patients and subsequently assembled into ScFv genes by SOE. The resulting ScFv genes were electrotransformed into E.coli TG1 and amplified with the co-infection of helper phage M13KO7 to obtain phage display library. The capacity and titer of the resulting library were detected. The phage antibody library with a capacity of approximately 3 × 109 cfu/μg was obtained. After amplification with helper phage, the titer of antibody library reached 5 × 1012 cfu/mL. Human ScFv library against ovarian tumor was constructed successfully, which laid a foundation for the screening of ovarian tumor specific ScFv for the radioimmunoimaging diagnosis of ovarian tumor.

  10. Influence of Sc3+ on LiMn2O4 cathode materials at elevated temperature

    Institute of Scientific and Technical Information of China (English)

    LIU Huiyong; DENG Ganqun; GUO Yonglang

    2008-01-01

    Sc3+-doped lithium manganese oxides were synthesized by solid-state reaction. The influences of doping element on structure,mean valence of manganese, and electrochemical performances were studied by X-ray diffraction (XRD), galvanostatic charge-discharge and cyclic voltammetric tests, and also electrochemical impedance spectroscopy (EIS). XRD tests showed that doped lithium manganese oxides were pure spinel structure without other phases. Redox titration and visible spectrophotometry tests indicated that the mean valence of man-ganese in doped lithium manganese oxides was higher than that of pure one. LiSc0.02Mn1.98O4 remained 92.9% of the initial specific discharge capacity after 50th cycle at a constant current of 50 m/g, and the reversibility of LiSc0.02Mn1.98O4 was improved in comparison with pure LiMn2O4 at 50 ℃. EIS indicated that film deposition on spinel particles was suppressed because of Sc3+ doping, and the charge transfer be-tween the surface film and spinel particles with increasing temperature for Sc3+-doped materials became easier as compared with undoped one.

  11. Effect of minor Sc and Zr on superplasticity of Al-Mg-Mn alloys

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The effect of Sc and Zr on the superplastic properties of Al-Mg-Mn alloy sheets was investigated by control experiment.The superplastic properties and the mechanism of superplastic deformation of the two alloys were studied by means of optical microscope, scanning electronic microscope and transmission electron microscope. The elongation to failure of Al-Mg-Mn-Sc-Zr alloy is larger than that of Al-Mg-Mn alloy at the same temperature and initial strain rate. The variation of strain rate sensitivity index is similar to that of elongation to failure. In addition, Al-Mg-Mn-Sc-Zr alloy exhibits higher strain rate superplastic property. The activation energies of the two alloys that are calculated by constitutive equation and linear regression method approach the energy of grain boundary diffusion. The addition of Sc and Zr decreases activation energy and improves the superplastic property of Al-Mg-Mn alloy. The addition of Sc and Zr refines the grain structure greatly. The main mechanism of superplastic deformation of the two alloys is grain boundary sliding accommodated by grain boundary diffusion. The fine grain structure and high density of grain boundary,benefit grain boundary sliding, and dynamic recrystallization brings new fine grain and high angle grain boundary which benefit grain boundary sliding too. Grain boundary diffusion, dislocation motion and dynamic recrystallization harmonize the grain boundary sliding during deformation.

  12. Microstructure dependent fatigue crack growth in Al–Mg–Sc alloy

    International Nuclear Information System (INIS)

    The fatigue crack growth behavior of Al–Mg–Sc alloy was investigated by tensile testing and fatigue testing. Different annealing treatments were applied to the alloy. Microstructure characterization of the alloy was carried out by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and optical microscopy (OM). The size of Al3(Sc1−xZrx) particle was calculated by software. The fatigue crack growth (FCG) rate (da/dN) was discussed with stress intensity factor range (ΔK) in Paris's region. The Paris exponent m and constants C were used to calculate the fatigue life. The fatigue process and crack closure effects were discussed with the yield strength and tensile strength of Al–Mg–Sc alloy. Results show that the microstructure, tensile strength and fatigue crack growth rate were greatly dependent on the annealing temperature, and the high resistance of Al–Mg–Sc alloy was mainly due to the combination microstructures of sub-grains, dislocations and these Al3(Sc1−xZrx) precipitates

  13. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct.

    OpenAIRE

    Shadel, G S; Clayton, D A

    1995-01-01

    In Saccharomyces cerevisiae mitochondria, sc-mtTFB is a 341-amino-acid transcription factor required for initiation of transcription from mitochondrial DNA promoters. Specific transcription in vitro requires only sc-mtTFB and the bacteriophage-related core sc-mtRNA polymerase. Mutational analysis of sc-mtTFB has defined two regions of the protein that are important for normal function both in vivo and in vitro. These regions overlap portions of the protein that exhibit similarity to conserved...

  14. Dislocation Core Structure and Peierls Stress of B2-Based AlSc in {110} Plane

    Science.gov (United States)

    Li, S. R.; Wu, X. Z.; Zhang, T.; Tian, Y. X.; Yan, Z. X.; Zhu, H. Z.

    2016-10-01

    The core structure and Peierls stress of , , and dislocations in {110} plane of B2-based AlSc (B2-AlSc) have been investigated using improved dislocation equations combined with the generalized stacking fault (GSF) energy. The truncated approximation method is utilized to construct the dissociated and undissociated dislocations in AlSc, then the effects of dislocation angles on the elastic strain energy and misfit energy are presented. Specifically, with increasing dislocation angle, the misfit energy, elastic strain energy, and total energy, and their corresponding stresses, decrease on the {110} and {110} slip systems. However, for {110} dislocation, all energies and corresponding stresses exhibit the relationship 0° > 54.7° > 35.3° > 90°. The misfit energy is always smaller than the elastic strain energy, even by one or two orders of magnitude, and their phases are always opposite.

  15. Magnetic anisotropy in the incommensurate ScFe{sub 4}Al{sub 8} system

    Energy Technology Data Exchange (ETDEWEB)

    Rećko, K., E-mail: k.recko@uwb.edu.pl [Faculty of Physics, University of Białystok, K. Ciołkowskiego 1L, 15-245 Białystok (Poland); Dobrzyński, L. [National Centre for Nuclear Research, A. Soltan 7, 05-400 Otwock-Świerk (Poland); Waliszewski, J.; Szymański, K. [Faculty of Physics, University of Białystok, K. Ciołkowskiego 1L, 15-245 Białystok (Poland)

    2015-08-15

    Neutron scattering and magnetization data are used for estimation of the spin ordering in ScFe{sub 4}Al{sub 8}. Results of experimental measurements are compared with the ground state configurations obtained by simulated annealing algorithms. The origins of the magnetocrystalline anisotropy of the scandium intermetallic alloy and the conditions of the coexistence of two different magnetic modulations as a function of the exchange integrals are discussed. The influence of the dipolar interactions for the noncollinearity and incommensurability in ScFe{sub 4}Al{sub 8} was determined. - Highlights: • We found dipolar and DM interactions as the anisotropy origins of 3d–3d–3p alloy. • We covered the explanation of incommensurability and noncollinearity of ScFe{sub 4}Al{sub 8}. • We discussed the magnetism resulting from competitiveness of exchange effects.

  16. Comparison of Response between RC and SC Containment Structures Subjected to Aircraft Impact

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sang Shup; Choi, In Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Tae Hyo [Hanyang University, Seoul (Korea, Republic of)

    2012-05-15

    Since the aircraft terror to the World Trade Center (WTC) on September 11, 2001, an aircraft impact problem has been increasingly interested. The possibilities of aircraft impacts against nuclear power plants are one of important category. To date, the impact load of the analysis on aircraft impacts has been applied to target structures in local areas by using the impact force-time history function of Riera. However, Riera forcing function is not recommended at the expectation of unreasonable damage or perforation to target structures. The numerical analysis of rc and sc containment structures subjected to aircraft impact is performed by using the AUTODYN-3D. It is carried out the four different types for RC and SC structures. Thus, in this study, the different behaviors of containment structures and the safety of SC structure are expected

  17. Vibrational structure of C 84 and Sc 2@C 84 analyzed by IR spectroscopy

    Science.gov (United States)

    Hulman, M.; Pichler, T.; Kuzmany, H.; Zerbetto, F.; Yamamoto, E.; Shinohara, H. N.

    1997-06-01

    The isomer III of Sc 2@C 84 was separated by multi-cycle HPLC purification. We present temperature dependent IR absorption measurements of Sc 2@C 84 which have been performed between 50 and 300 K and between 400 and 5000 cm -1, respectively. The vibrational structure of the endohedral compound is compared to the structure of unfilled C 84. We find a strong overall broadening of the vibrational modes in Sc 2@C 84. Also some of the vibrational absorption lines are strongly enhanced if compared to the spectrum for the empty cage. With decreasing temperature, a dramatic narrowing of the lines in the spectral range between 700 and 800 cm -1 is observed.

  18. Precursors to ScS Phases and dipping interface in the upper mantle beneath southwestern Japan

    Science.gov (United States)

    Nakanishi, Ichiro

    1980-10-01

    Longitudinally polarized precursors to ScS phases observed in the Shikoku and Chugoku districts, southwestern Japan, are interpreted as ScSp arrivals, resulting from ScSto-P conversions at a dipping interface in the upper mantle. An ScSp phase recorded in the Tohoku district, northeastern Japan, also is examined. The location of the conversion interface, beneath the Shikoku district, determined from the ScSp observations agrees with the upper boundary of the descending Philippine Sea plate inferred from the seismicity pattern of subcrustal earthquakes. It has been proposed on the basis of no seismic activity in the upper mantle that the leading edge of the downgoing Philippine Sea plate has not reached the upper mantle beneath the Chugoku district. The ScSp observations, however, present a possibility of the existence of an aseismic continuation of the Philippine Sea plate in the upper mantle beneath the Chugoku district. An alternative interpretation of the conversion interface may be possible. The interface inferred in the present study may correspond to a boundary between the asthenosphere and an aseismic dead slab which had descended from the Nankai trough at the previous cycle of plate convergence. This ScS-to-P conversion interface may be closely related to the late Quaternary volcanism in the Chugoku district. Low-velocity zones are required in the vicinity of the inclined ScS-to-P conversion interfaces in the upper mantle beneath southwestern and northeastern Japan in order to explain the observed relative polarity between the ScSp and ScS phases. The first-order discontinuity of the velocity contrast of about 6%, which has been suggested between the lithosphere and overlying asthenosphere, cannot simultaneously explain all of the observed amplitudes, periods, and polarity of the ScSp phases. The simplest model which explains these observations is the low-velocity zone with the sharp upper and transitional lower boundaries. This low-velocity zone may be

  19. Laboratory oscillator strengths of Sc I in the near-infrared region for astrophysical applications

    CERN Document Server

    Pehlivan, A; Hartman, H

    2015-01-01

    Context. Atomic data is crucial for astrophysical investigations. To understand the formation and evolution of stars, we need to analyse their observed spectra. Analysing a spectrum of a star requires information about the properties of atomic lines, such as wavelengths and oscillator strengths. However, atomic data of some elements are scarce, particularly in the infrared region, and this paper is part of an effort to improve the situation on near-IR atomic data. Aims. This paper investigates the spectrum of neutral scandium, Sc i, from laboratory measurements and improves the atomic data of Sc i lines in the infrared region covering lines in R, I, J, and K bands. Especially, we focus on measuring oscillator strengths for Sc i lines connecting the levels with 4p and 4s configurations. Methods. We combined experimental branching fractions with radiative lifetimes from the literature to derive oscillator strengths (f - values). Intensity-calibrated spectra with high spectral resolution were recorded with Fouri...

  20. Comparison of Response between RC and SC Containment Structures Subjected to Aircraft Impact

    International Nuclear Information System (INIS)

    Since the aircraft terror to the World Trade Center (WTC) on September 11, 2001, an aircraft impact problem has been increasingly interested. The possibilities of aircraft impacts against nuclear power plants are one of important category. To date, the impact load of the analysis on aircraft impacts has been applied to target structures in local areas by using the impact force-time history function of Riera. However, Riera forcing function is not recommended at the expectation of unreasonable damage or perforation to target structures. The numerical analysis of rc and sc containment structures subjected to aircraft impact is performed by using the AUTODYN-3D. It is carried out the four different types for RC and SC structures. Thus, in this study, the different behaviors of containment structures and the safety of SC structure are expected

  1. Enhanced hardness in epitaxial TiAlScN alloy thin films and rocksalt TiN/(Al,Sc)N superlattices

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Bivas [School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); Lawrence, Samantha K.; Bahr, David F. [School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Schroeder, Jeremy L.; Birch, Jens [Thin Film Physics Division, Department of Physics, Chemistry, and Biology (IFM), Linköping University, SE-581 83 Linköping (Sweden); Sands, Timothy D. [School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 (United States)

    2014-10-13

    High hardness TiAlN alloys for wear-resistant coatings exhibit limited lifetimes at elevated temperatures due to a cubic-AlN to hexagonal-AlN phase transformation that leads to decreasing hardness. We enhance the hardness (up to 46 GPa) and maximum operating temperature (up to 1050 °C) of TiAlN-based coatings by alloying with scandium nitride to form both an epitaxial TiAlScN alloy film and epitaxial rocksalt TiN/(Al,Sc)N superlattices on MgO substrates. The superlattice hardness increases with decreasing period thickness, which is understood by the Orowan bowing mechanism of the confined layer slip model. These results make them worthy of additional research for industrial coating applications.

  2. Preliminary Analysis of the Social and Scientific Impact of the UAEM-ININ M.Sc. and D.Sc. Graduate Programme in Medical Physics

    Science.gov (United States)

    Mitsoura, Eleni; Isaac-Olive, Keila; Torres-Garcia, Eugenio; Camacho-Lopez, Miguel Angel; Hardy-Perez, Alberto

    2010-12-01

    Sponsored by the International Atomic Energy Agency (IAEA) in 1994, the Instituto Nacional de Investigaciones Nucleares (ININ) started in Mexico a teaching and training programme (Diplomado) in Radiotherapy Medical Physics. Based on this experience, the Universidad Autónoma del Estado de México (UAEM) and the Instituto Nacional de Investigaciones Nucleares (ININ) launched two years later, the first Graduate Programme in Science (M.Sc. and D.Sc.), specialised in Medical Physics in Mexico. A preliminary analysis of the social and scientific impact of the UAEM-ININ Programme is presented in this work based on the achievements attained, regarding the number of graduated Medical Physicists, their geographic and academic origin, their current professional activities and the number of scientific publications produced as a result of the thesis, as well as their citations.

  3. The first principle study of Ni2ScGa and Ni2TiGa

    International Nuclear Information System (INIS)

    We computed the electronic structure, elastic moduli, vibrational properties, and Ni2TiGa and Ni2ScGa alloys in the cubic L21 structure. The obtained equilibrium lattice constants of these alloys are in good agreement with available data. In cubic systems, there are three independent elastic constants, namely C11, C12 and C44. We calculated elastic constants in L21 structure for Ni2TiGa and Ni2ScGa using the energy-strain method. The electronic band structure, total and partial density of states for these alloys were investigated within density functional theory using the plane-wave pseudopotential method implemented in Quantum-Espresso program package. From band structure, total and projected density of states, we observed metallic characters of these compounds. The electronic calculation indicate that the predominant contributions of the density of states at Fermi level come from the Ni 3d states and Sc 3d states for Ni2TiGa, Ni 3d states and Sc 3d states for Ni2ScGa. The computed density of states at Fermi energy are 2.22 states/eV Cell for Ni2TiGa, 0.76 states/eV Cell for Ni2ScGa. The vibrational properties were obtained using a linear response in the framework at the density functional perturbation theory. For the alloys, the results show that the L21 phase is unstable since the phonon calculations have imagine modes

  4. Synergistic Antivascular and Antitumor Efficacy with Combined Cediranib and SC6889 in Intracranial Mouse Glioma.

    Directory of Open Access Journals (Sweden)

    Merryl R Lobo

    Full Text Available Prognosis remains extremely poor for malignant glioma. Targeted therapeutic approaches, including single agent anti-angiogenic and proteasome inhibition strategies, have not resulted in sustained anti-glioma clinical efficacy. We tested the anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib and the novel proteasome inhibitor SC68896, in combination and as single agents. To assess anti-angiogenic effects and evaluate efficacy we employed 4C8 intracranial mouse glioma and a dual-bolus perfusion MRI approach to measure Ktrans, relative cerebral blood flow and volume (rCBF, rCBV, and relative mean transit time (rMTT in combination with anatomical MRI measurements of tumor growth. While single agent cediranib or SC68896 treatment did not alter tumor growth or survival, combined cediranib/SC68896 significantly delayed tumor growth and increased median survival by 2-fold, compared to untreated. This was accompanied by substantially increased tumor necrosis in the cediranib/SC68896 group (p<0.01, not observed with single agent treatments. Mean vessel density was significantly lower, and mean vessel lumen area was significantly higher, for the combined cediranib/SC68896 group versus untreated. Consistent with our previous findings, cediranib alone did not significantly alter mean tumor rCBF, rCBV, rMTT, or Ktrans. In contrast, SC68896 reduced rCBF in comparison to untreated, but without concomitant reductions in rCBV, rMTT, or Ktrans. Importantly, combined cediranib/SC68896 substantially reduced rCBF, rCBV. rMTT, and Ktrans. A novel analysis of Ktrans/rCBV suggests that changes in Ktrans with time and/or treatment are related to altered total vascular surface area. The data suggest that combined cediranib/SC68896 induced potent anti-angiogenic effects, resulting in increased vascular efficiency and reduced extravasation, consistent with a process of vascular normalization. The study represents the first demonstration

  5. Preparation, microstructure and properties of Al-Zn-Mg-Sc alloy tubes

    Institute of Scientific and Technical Information of China (English)

    何振波; 尹志民; 林森; 邓英; 商宝川; 周向

    2010-01-01

    The Al-6.0Zn-2.0Mg-0.2Sc-0.10Zr hollow tube ingots, prepared by semi-continuous casting technology, were subjected to ho- mogenization treatment, hot extrusion, intermediate annealing, tension, solution and aging treatment. The microstructures and properties of as-cast Al-Zn-Mg-Sc alloy at different homogenization treatment conditions were studied using hardness measurement, X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The results showed th...

  6. Health physics experience during 46Sc radiotracer injection at Kolkata Port, Kolkata

    International Nuclear Information System (INIS)

    To examine the suitability of dumping site for dredged sediment, 46Sc in scandium glass matrix is mainly used for the investigation at ports and harbours. In this paper authors share Health Physics experience on control of personnel exposure in order to achieve ALARA. About 260 GBq of 46Sc was used for sediment transport study near SAGAR Island at Kolkata Port, Kolkata. During the study, the maximum dose was found to be less than 0.37 mSv, which is 1.23 % of the authorized annual effective dose limits for occupational radiation worker. The average dose for the experiment was computed as 0.21 mSv. (author)

  7. Supervising M.Sc. Students working in the 100 Gigabit Ethernet field using OPNET Modeler

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Berger, Michael Stübert; Wessing, Henrik

    2010-01-01

    This paper deals with supervision methods for M.Sc. students who are using OPNET Modeler for their thesis work within the field of 100 Gigabit Ethernet. We detail how we use OPNET Modeler in our M.Sc. projects at the Technical University of Denmark. In particular, we discuss on how we teach...... students to learn OPNET independently and in a short timeframe, and we outline what students find challenging and rewarding by using OPNET Modeler. Furthermore, we show some cases on how OPNET was applied in specific projects within the field of 100 Gigabit Ethernet....

  8. On measuring the UNK SC-dipole bending strength with rotating pick-up coil

    International Nuclear Information System (INIS)

    The experience in measuring the SC-dipole bending strength with the spotting method shown this measurement to be the most complicated and expensive. A convenient and simple method of rotating pick-up coil, which can not provide the required accuracy, may be used for this measurement combined with NMR measurements in the dipole central part. The physical ground and description of the method are given in the paper. The analysis of the errors and measurement results of the SPDMI SC-dipoles are presented. 9 refs..; 7 figs

  9. High-pressure study of substrate material ScAlMgO4

    OpenAIRE

    Errandonea, D.; R. S. Kumar; Ruiz-Fuertes, J.; Segura, A.; Haussuehl, E.

    2011-01-01

    We report on the structural properties of ScAlMgO4 studied under quasi-hydrostatic pressure using synchrotron high-pressure x-ray diffraction up to 40 GPa. We also report on single-crystal studies of ScAlMgO4 performed at 300 K and 100 K. We found that the low-pressure phase remains stable up to 24 GPa. At 28 GPa, we detected a reversible phase transformation. The high-pressure phase is assigned to a monoclinic distortion of the low-pressure phase. No additional phase transition is observed u...

  10. Observation of coexistence of ferroelectric and antiferroelectric phases in Sc substituted BiFeO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Durga Rao, T.; Asthana, Saket, E-mail: asthanas@iith.ac.in; Niranjan, Manish K.

    2015-09-05

    Highlights: • Coexisting ferro- and antiferroelectric phases in Sc substituted compounds. • Structural studies (XRD and Raman) supports the incorporation of Sc at B-site. • Presence of non-centrosymmetric monoclinic phase correlates with AFE ordering. • Grain resistance and activation energies increase with the Sc-content. • Electrical relaxations are originated due to oxygen vacancy movements. - Abstract: Polycrystalline BiFe{sub 1−x}Sc{sub x}O{sub 3} (x = 0, 0.05, 0.10 and 0.15) compounds were prepared using solid state reaction route. The X-ray diffraction patterns showed that Sc substitution stabilized the crystal structure in rhombohedral structure with R3c space group along with nominal percentage of monoclinic structure with Cm space group. Raman and FTIR measurements revealed that the substituent replaced Fe-ions and caused structural distortions. Co-existence of ferroelectric and antiferroelectric phases were observed in Sc substituted BiFeO{sub 3} and antiferroelectric phase is found to be evolved at the expense of ferroelectric phase with the Sc content. The electric field driven effects indicated that antiferroelectric phase was suppressed and ferroelectric phase was enriched. Frequency dependence of dielectric constant (ε{sub r}) and dielectric loss tangent (tan δ) at different temperatures were investigated. Further, grain resistances and grain boundary resistances were increased with the Sc content. Activation energies estimated from dielectric, impedance and modulus data indicated that these relaxations originated presumably due to the oxygen vacancy movements.

  11. Medialogi (Dansk informations brochure om Medialogi-uddannelsen, 1. til 10. semester (B.Sc. & Cand.Scient))

    DEFF Research Database (Denmark)

    Andersen, Hans Jørgen

    2006-01-01

    Informationsbrochure, 28 sider, om Medialogi uddannelsen (Cand. Scient.), der udbydes af Aalborg Universitet i Aalborg, Esbjerg og København. Brochuren beskriver 1. til 10. semester af uddannelsen (B.Sc. og M.Sc.). Informationen er primært rettet mod potentielle ansøgere til Medialogi uddannelsen...

  12. Curriculum (Study Programme) for the 3rd to 6th semester of the B.Sc., Medialogy, at Aalborg University

    DEFF Research Database (Denmark)

    Nordahl, Rolf; Serafin, Stefania; Lavatino, Salvatore

    2004-01-01

    Major revision of the original curriculum of the B.Sc., Medialogy. Significant changes (extensive restructuring) in comparison with the first version of the curriculum.......Major revision of the original curriculum of the B.Sc., Medialogy. Significant changes (extensive restructuring) in comparison with the first version of the curriculum....

  13. Naked (C5Me5)(2)M cations (M = Sc, Ti, and V) and their fluoroarene complexes

    NARCIS (Netherlands)

    Bouwkamp, MW; Budzelaar, PHM; Gercama, J; Morales, ID; de Wolf, J; Meetsma, A; Troyanov, SI; Teuben, JH; Hessen, B; Budzelaar, Peter H.M.; Hierro Morales, Isabel Del; Troyanov, Sergei I.

    2005-01-01

    The ionic metallocene complexes [Cp*M-2][BPh4] (CP* = C5Me5) of the trivalent 3d metals Sc, Ti, and V were synthesized and structurally characterized. For M Sc, the anion interacts weakly with the metal center through one of the phenyl groups, but for M = Ti and V, the cations are naked. They each c

  14. Effect of minor Sc and Zr addition on microstructures and mechanical properties of Al-Zn-Mg-Cu alloys

    Institute of Scientific and Technical Information of China (English)

    ZOU Liang; PAN Qing-lin; HE Yun-bin; WANG Chang-zhen; LIANG Wen-jie

    2007-01-01

    Three kinds of Al-Zn-Mg-Cu based alloys with 0.22%, 0.36%(Sc+Zr) (mass fraction, %), and without Sc, Zr addition were prepared by ingot metallurgy. By using optical microscopy, transmission electronic microscopy and scanning electron microscopy, the effects of microalloying elements of Sc, Zr on the microstructure of super-high-strength Al-Zn-Mg-Cu alloys related to mechanical properties were investigated. The tensile properties and microstructures of the studied alloys under different heat treatment conditions were studied. The addition of minor Sc, Zr results in the formation of Al3(Sc,Zr) particles. These particles are highly effective in refining the microstructures, retarding recrystallization, pinning dislocations and subboundaries. The strength of Al-Zn-Mg-Cu alloys was greatly improved by simultaneously adding minor Sc, Zr, meanwhile the ductility of the studied alloys remains at a higher level. The 0.36%(Sc+Zr) alloys gain the optimal properties after 465 ℃/h solution and 120 ℃/24 h aging. The increment of strength is mainly due to strengthening of fine grain and substructure and precipitation of Al3(Sc, Zr) particles.

  15. Effect of minor Sc and Zr addition on grain refinement of as-cast AI-Zn-Mg-Cu alloys

    Institute of Scientific and Technical Information of China (English)

    He Yongdong; Zhang Xinming; Cao Zhiqiang

    2009-01-01

    The optical microscopy and scanning electron microscopy as well as energy dispersive spectroscopy were employed to investigate the influence of joint addition of Sc and Zr on grain refinement of AI-Zn-Mg-Cu alloys.Results show that the addition of 0.20% Sc has a little effect on grain refinement because Sc is mainly dissolved into the matrix and hardly any primary Al3Sc particles are precipitated. The alloy with addition of 0.30% Sc and 0.16%Zr has more equiaxed grains than that of others,giving cast grain sizes as fine as 13μm. This is because the Sc substitutes for AI atom in the AI-Zr crystal cell and forms AI-Sc-Zr unit cell,which grows and becomes AI3(Scx,Zr1.x)particle,acting as a nucleus for the formation of a-AI. The addition of 0.04% Ti and 0.008% B makes the grain size drop from 250 μm to 50 μm. Its refinement effect is less than the 13 μm achieved by the alloy including 0.30% Sc and 0.16% Zr.

  16. SC-IAT范式下大学生感恩的内隐性%An Implicit Study on Undergraduates’Gratitude under SC-IAT Paradigm

    Institute of Scientific and Technical Information of China (English)

    何安明; 惠秋平; 刘华山

    2014-01-01

    objective:To explore the feasibility of measuring undergraduates’gratitude by Single Category Implicit Association Test( SC-IAT)and analyze the relationship between implicit gratitude and explicit gratitude. Procedures and Methods:Preliminary research se-lected 20 words related to grace from the modern Chinese dictionary,and selected each 20 positive/negative words related to gratitude from Chinese idioms dictionary,according to the evaluation results of 65 undergraduates,the 8 words related to grace,and each 8 posi-tive/negative words were screened out for the formal research. In formal research,the SC-IAT gratitude measurement procedures was developed with software inquisit 3. 0. 2. 0,144 undergraduates were simultaneously assigned to receive SC-IAT test and explicit grati-tude measurement by Adolescent Gratitude Scale( AGS),and the relationship between implicit gratitude and explicit gratitude was ana-lyzed via correlate technology. Results:Implicit effects of undergraduates’gratitude measured by SC-IAT was significant(p0. 05),and there was no significant correlation between implicit gratitude and explicit gratitude(p>0. 05). Conclusions:(1)The undergraduates generally have positive implicit gratitude;(2)Implicit gratitude is separated from explicit gratitude,they belong to two different constructions.%目的:研究探讨了单类内隐联想测验( SC-IAT)测量大学生感恩的可行性,并分析内隐感恩与外显感恩的关系。方法:采用inquisit3.0.2.0编制SC-IAT感恩测量程序,测量了大学生的内隐感恩;采用青少年感恩量表( AGS)测量了大学生的外显感恩,并运用相关技术分析两者之间的关系。结果:采用SC-IAT测量大学生感恩的内隐效应显著,内隐感恩不存在性别、生源地和独生与否等人口统计学指标上的显著差异,大学生的内隐感恩与外显感恩之间相关不显著。结论:(1)大学生整体上存在着积极的内隐感恩(;2

  17. Comparison of the texture evolution in cold rolled DC and SC AA 5182 aluminum alloys

    International Nuclear Information System (INIS)

    The hot bands of direct chill cast (DC) and strip cast (SC) AA 5182 aluminum alloys were annealed at 454 deg. C for 3 h, and then cold rolled to different reductions. The ODFs of the cold rolled samples were determined by X-ray diffraction in order to compare the texture evolution of DC and SC AA 5182 aluminum alloys during rolling. The texture volume fractions were computed by a new method, in which the Euler space representing all possible crystallographic orientations in rolling was subdivided into the cube, r-cube, Goss, r-Goss, β fiber, and random orientation regions based on the slip pattern combined with the characteristics of microstructure and texture. Empirical formulae of the texture volume fractions and true strain were constructed to predict the texture of cold rolled DC and SC AA 5182 aluminum alloys. The results show that the processing method (DC vs. SC) strongly affects the texture after annealing at 454 deg. C and the texture evolution during the subsequent rolling

  18. Automatic symbolic analysis of SC networks using a modified nodal approach

    NARCIS (Netherlands)

    Zivkovic, V.A.; Petkovic, P.M.; Milanovic, D.P.

    1998-01-01

    This paper presents a symbolic analysis of Switched-Capacitor (SC) circuits in the z-domain using Modified Nodal Approach (MNA). We have selected the MNA method as one of the widely established approaches in circuit analysis. The analyses are performed using SymsimC symbolic simulator which also ena

  19. Biogas Upgrading Using SOEC with a Ni-ScYSZ Electrode

    DEFF Research Database (Denmark)

    Ebbesen, Sune Dalgaard; Bøgild Hansen, John; Mogensen, Mogens Bjerg

    2013-01-01

    Biogas consists mainly of CH4, CO2 and small amounts of H2S. The value of biogas will increase significantly if it is upgraded to pipeline quality by converting CO2 and H2O in the biogas to CO and H2 using a Solid Oxide Electrolysis Cell (SOEC) followed by methanation. The Ni-ScYSZ-cermet electrode...

  20. Thermography of semi-transparent materials by a FLIR ThermaCAM SC3000 infrared camera

    NARCIS (Netherlands)

    Van der Tempel, L.

    2011-01-01

    An acceptance test for thermography of semi-transparent materials by a FLIR ThermaCAM SC3000 infrared camera with 8.0 µm low-wavelength-pass filter has been developed and performed on polycarbonate, PEN, quartz, Corning 1737 glass, G427 cone glas, G443 screen glass, Schott Zerodur, silicon and a bl

  1. Atomic structure and phason modes of the Sc-Zn icosahedral quasicrystal.

    Science.gov (United States)

    Yamada, Tsunetomo; Takakura, Hiroyuki; Euchner, Holger; Pay Gómez, Cesar; Bosak, Alexei; Fertey, Pierre; de Boissieu, Marc

    2016-07-01

    The detailed atomic structure of the binary icosahedral (i) ScZn7.33 quasicrystal has been investigated by means of high-resolution synchrotron single-crystal X-ray diffraction and absolute scale measurements of diffuse scattering. The average atomic structure has been solved using the measured Bragg intensity data based on a six-dimensional model that is isostructural to the i-YbCd5.7 one. The structure is described with a quasiperiodic packing of large Tsai-type rhombic triacontahedron clusters and double Friauf polyhedra (DFP), both resulting from a close-packing of a large (Sc) and a small (Zn) atom. The difference in chemical composition between i-ScZn7.33 and i-YbCd5.7 was found to lie in the icosahedron shell and the DFP where in i-ScZn7.33 chemical disorder occurs on the large atom sites, which induces a significant distortion to the structure units. The intensity in reciprocal space displays a substantial amount of diffuse scattering with anisotropic distribution, located around the strong Bragg peaks, that can be fully interpreted as resulting from phason fluctuations, with a ratio of the phason elastic constants K 2/K 1 = -0.53, i.e. close to a threefold instability limit. This induces a relatively large perpendicular (or phason) Debye-Waller factor, which explains the vanishing of 'high-Q perp' reflections. PMID:27437112

  2. UAS Integration in the NAS Project Overview: RTCA SC-228 Plenary DAA Working Group 5

    Science.gov (United States)

    Randall, Debra K.

    2014-01-01

    The presentation is intended to allow the public to know and understand NASA's plans for integrated test to allow them the opportunity to provide feedback and suggestions. The integrated testing will support verification and validation of the RTCA SC-228 UAS minimum operation performance standard requirements.

  3. 77 FR 15258 - Special Local Regulations; Patriot Challenge Kayak Race, Ashley River, Charleston, SC

    Science.gov (United States)

    2012-03-15

    ... Challenge Kayak Race, Ashley River, Charleston, SC in the Federal Register (76 FR 79571). We received no... between Shutes Folly Island and the Charleston peninsula, and then turn around in Tidewater Reach. The..., head north between Shutes Folly Island and the Charleston peninsula, and then turn around in...

  4. Spatial Frequency Scheduling for Uplink SC-FDMA based Linearly Precoded LTE Multiuser MIMO Systems

    DEFF Research Database (Denmark)

    Lin, Zihuai; Xiao, Pei; Sørensen, Troels Bundgaard;

    2010-01-01

    This paper investigates the performance of the 3GPP Long Term Evolution (LTE) uplink Single Carrier (SC) Frequency Division Multiple Access (FDMA) based linearly precoded multiuserMultiple InputMultiple Output (MIMO) systems with frequency domain packet scheduling. A mathematical expression...

  5. Rheological Modeling with Hookean Bead-Spring Cubes (SC, BBC and FCC)

    NARCIS (Netherlands)

    Denneman, A.I.M.; Jongschaap, R.J.J.; Mellema, J.

    1998-01-01

    In this study a general bead-spring model is used for predicting some rheological properties of a cubic bead-spring structure of arbitrary size immersed in a Newtonian solvent. The topology of this bead-spring structure is based upon the well-known cubic crystals (SC, BCC or FCC) and it consists of

  6. 75 FR 34170 - Plastic Omnium Automotive Exteriors, LLC, Anderson, SC; Plastic Omnium Automotive Exteriors, LLC...

    Science.gov (United States)

    2010-06-16

    ... Assistance on March 18, 2010, applicable to workers of Plastic Omnium Automotive Exteriors, LLC, Anderson, South Carolina. The notice was published in the Federal Register April 23, 2010 (75 FR 21356). The... Employment and Training Administration Plastic Omnium Automotive Exteriors, LLC, Anderson, SC; Plastic...

  7. 76 FR 35086 - Atlantic Bank & Trust, Charleston, SC; Notice of Appointment of Receiver

    Science.gov (United States)

    2011-06-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision Atlantic Bank & Trust, Charleston, SC; Notice of Appointment of Receiver Notice is hereby given that, pursuant to the authority contained in section 5(d)(2) of the Home Owners' Loan Act, the Office of Thrift...

  8. CERN Technical Training 2004: New Short Course III (SC III) on Microsoft Outlook - Meetings and Delegation

    CERN Multimedia

    Monique Duval

    2004-01-01

    The CERN Technical Training programme is now proposing a new format for courses on Microsoft Outlook. Three two-hours Short Courses (SC) cover basic and advanced functionalities of the recommended mail client for email at CERN. Each module can be followed independently. The next scheduled session of the 3rd module will take place as follows: Outlook (SC III): Meetings and Delegation. Next session: 9.11.2004 (14:00-16:00) SC III will cover how to organise and manage meetings, work with meeting requests, share tasks, and use email and calendar delegation. The number of participants to each session is limited to 8. The instructor is English-French bilingual, and she will be available some time after each session to answer specific questions, or provide further explanations following demand. The cost of attending any SC module on Outlook is 70.- CHF. The above session will be confirmed if there are enough participants, and the attendance costs will be lower in case of a full class. If you are interested in...

  9. Pressure-induced structural transformations in the molybdate Sc-2(MoO4)(3)

    DEFF Research Database (Denmark)

    Paraguassu, W.; Maczka, M.; Filho, A. G. Sonza;

    2004-01-01

    High pressure Raman scattering and x-ray diffraction studies of the molybdate Sc-2(MoO4)(3) are presented. A sequence of changing symmetry effects is observed through two structural phase transitions ending up with an amorphous state. The observed two structural phase transformations are reversib...

  10. Effect of homogenization treatment on microstructure and properties of Al-Mg-Mn-Sc-Zr alloy

    Institute of Scientific and Technical Information of China (English)

    NIE Bo; YIN Zhi-min; ZHU Da-peng; PENG Yong-yi; JIANG Feng; HUANG Ji-wu

    2007-01-01

    The effect of homogenization on the hardness, tensile properties, electrical conductivity and microstructure of as-cast Al-6Mg-0.4Mn-0.25Sc-0.12Zr alloy was studied. The results show that during homogenization as-cast studied alloy has obviously hardening effect that is similar to aging hardening behavior in traditional Al alloys. The precipitates are mainly Al3(Sc,Zr) and Al6Mn.When homogenization temperature increases the hardness peak value is declined and the time corresponding to hardness peak value is shortened. The electrical conductivity of the alloy monotonously increases with increasing homogenization temperature and time.The decomposition of the supersaturated solid solution containing Sc and Zr which is formed during direct chilling casting and the precipitation of Al3(Sc, Zr) cause hardness increasing. The depletion of the matrix solid solubility decreases the ability of electron scattering in the alloy, resulting in the electrical conductivity increased. Tensile property result at hot rolling state shows that the optimal homogenization treatment processing is holding at 300-350 ℃ for 6-8 h.

  11. A Fully Differential 2 GHz CMOS Subsampling-Mixer with SC-Amplifier

    DEFF Research Database (Denmark)

    Nielsen, Per Asbeck; Fallesen, Carsten; Jørgensen, Allan

    1997-01-01

    A differential CMOS subsampling-mixer for 2 GHz is presented. The mixer is followed by a offset compensated SC gain stage that converts the differential signal to a ground referred signal. A two phase clock scheme with additional delayed clocks is employed to ensure that the sampling process...

  12. 76 FR 37700 - Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC

    Science.gov (United States)

    2011-06-28

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking... Waterway in Myrtle Beach, South Carolina during the Myrtle Beach Triathlon. The Myrtle Beach...

  13. 77 FR 14321 - Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC

    Science.gov (United States)

    2012-03-09

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Myrtle Beach Triathlon, Atlantic Intracoastal Waterway, Myrtle Beach, SC AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking... Waterway in Myrtle Beach, South Carolina during the Myrtle Beach Triathlon. The Myrtle Beach...

  14. Final Report for Research supported by US DoE grant DE-SC0006721

    Energy Technology Data Exchange (ETDEWEB)

    Brizard, Alain J. [Saint Michael' s College

    2014-08-27

    A final report is presented on research carried out by Alain J. Brizard (Principal Investigator) with funding provided by the U.S. DoE grant No. DE-SC0006721 during the period of 08/01/2011 to 07/31/2014.

  15. Data of evolutionary structure change: 1A4SC-2ONNF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1A4SC-2ONNF 1A4S 2ONN C F AQLVDSMPSASTGSVVVTDDLNYWGGRRIKSKDGATTEP...KVMEMSAK-TVKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVG...ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA...----- EEE EEEEEE HHHHHHHH EEEE HHHHHHHHHH EEE GGG EEE GGG EEEEEEEEE -- EVID>...hain> 2ONN F 2ONNF

  16. Anomalously high thermoelectric power factor in epitaxial ScN thin films

    DEFF Research Database (Denmark)

    Kerdsongpanya, Sit; Van Nong, Ngo; Pryds, Nini;

    2011-01-01

    Thermoelectric properties of ScN thin films grown by reactive magnetron sputtering on Al2O3(0001) wafers are reported. X-ray diffraction and elastic recoil detection analyses show that the composition of the films is close to stoichiometry with trace amounts (∼1 at. % in total) of C, O, and F. We...

  17. Self-assembly of the hydrophobin SC3 proceeds via two structural intermediates

    NARCIS (Netherlands)

    Vocht, Marcel L. de; Reviakine, Ilya; Ulrich, Wolf-Peter; Bergsma-Schutter, Wilma; Wösten, Han A.B.; Vogel, Horst; Brisson, Alain; Wessels, Joseph G.H.; Robillard, George T.

    2002-01-01

    Hydrophobins self assemble into amphipathic films at hydrophobic–hydrophilic interfaces. These proteins are involved in a broad range of processes in fungal development. We have studied the conformational changes that accompany the self-assembly of the hydrophobin SC3 with polarization-modulation in

  18. Construction, Expression and In Vitro Biological Behaviors of Ig scFv Fragment in Patients with Chronic B Cell Leukemia

    Institute of Scientific and Technical Information of China (English)

    ZHU Lijuan; LIAO Wenjun; ZHU Huifen; LEI Ping; WANG Zhihua; SHAO Jingfang; ZHANG Yue; SHEN Guanxin

    2006-01-01

    The expression vector of SmIg scFv fragment was constructed in patient with B cell chronic lymphocyte leukemia (B-CLL) and expressed in E. coli to obtain scFv fragment, and the effect of the protein on the proliferation of stimulated peripheral blood mononuclear cells (PBMC) was investigated in vitro. Two pairs of primers were designed, and variable region genes of light chain and heavy chain were amplified by PCR respectively from the pGEM-T vectors previously constructed in our laboratory which containing light chain gene or Fd fragment of heavy chain gene. The PCR product was digested, purified and inserted into pHEN2 vector to construct the soluble expression vector pHEN2-scFv. After the induction by IPTG, the scFv protein was identified by SDSPAGE electrophoresis and purified by Ni-NTA-Chromatography. MTT was used to determine the effect of purified protein on the proliferation of stimulated PBMC in vitro. Plasmid PCR and restriction enzyme digestion of pHEN2-scFv revealed the pHEN2-scFv vector was constructed successfully. Id-scFv protein was expressed in positive clone after induced by IPTG. SDS-PAGE analysis showed that the relative molecular weight of fusion protein was about 30 kD (1 kD=0.9921 ku),which was consistent with the theoretically predicted value. Proliferation of PBMC could be induced by purified Id-scFv. It was suggested that the expression vector of SmIg scFv fragment was constructed successfully, and scFv protein was expressed and secreted from E. coli, which could induce proliferation of PBMC. This may lay an experimental foundation for further research of IdHSP complex vaccine for B-CLL.

  19. An optimized Fermentation and Purification Process for a Recombinant Human Antibody ScFv-Fc Fragment Expressed in Pichia Pastoris%重组人小分子抗体ScFv-Fc发酵条件的优化及纯化

    Institute of Scientific and Technical Information of China (English)

    王丁丁; 苏曼曼; 胡丽莉; 袁丽颖; 颜炜群

    2011-01-01

    Objective: To obtain an optimized fermentation and purification process for high-level production of a recombinant human antibody ScFv-Fc fragment expression secreted in Pichia pastoris. Methods: The growth conditions of the transformant strain were optimized in 50 ml conical tubes including pH, methanol concentration and inducing time. The ScFv-Fc was purified using a two-step scheme: ammonium sulfate fractionation, protein A Sepharose. Results: ScFv-Fc production was found to increase with 0.5% (v/v) methanol concentration after 72 h induction. Protein production was also greatly affected by pH, resulting in higher yields at 5.2 pH value. The ScFv-Fc was purified more than 94% purity by using protein A Sepharose. Conclusions: The results provided a best process for expression and purification of functional recombinant human monoclonal antibody ScFv-Fc. It suggests a potential use of this antibody generating method by Pichia pastoris and indicates the potential of scFv-Fc fusion proteins as therapeutic candidates.%目的:研究重组人小分子抗体ScFv-Fc在毕赤酵母中分泌表达的最佳条件,以及ScFv-Fc的纯化方法.方法:分别从甲醇浓度、pH、诱导时间等方面对毕赤酵母重组菌株产生ScFv-Fc的发酵过程进行了优化;通过硫酸铵沉淀结合protein A亲和层析柱,对ScFv-Fc的纯化方法进行了研究.结果:确定ScFv-Fc在毕赤酵母中分泌表达的最佳条件为:在pH5.2的条件下,以0.5%甲醇诱导72 h.经过protein A亲和层析柱纯化后,ScFv-Fc纯度可达94%以上.结论:确定了ScFv-Fc在毕赤酵母中分泌表达的最佳条件以及纯化方法,为重组抗体分子诊断、治疗试剂的开发以及抗体的人源化奠定了物质基础.

  20. Recombinant norovirus-specific scFv inhibit virus-like particle binding to cellular ligands

    Directory of Open Access Journals (Sweden)

    Hardy Michele E

    2008-01-01

    Full Text Available Abstract Background Noroviruses cause epidemic outbreaks of gastrointestinal illness in all age-groups. The rapid onset and ease of person-to-person transmission suggest that inhibitors of the initial steps of virus binding to susceptible cells have value in limiting spread and outbreak persistence. We previously generated a monoclonal antibody (mAb 54.6 that blocks binding of recombinant norovirus-like particles (VLP to Caco-2 intestinal cells and inhibits VLP-mediated hemagglutination. In this study, we engineered the antigen binding domains of mAb 54.6 into a single chain variable fragment (scFv and tested whether these scFv could function as cell binding inhibitors, similar to the parent mAb. Results The scFv54.6 construct was engineered to encode the light (VL and heavy (VH variable domains of mAb 54.6 separated by a flexible peptide linker, and this recombinant protein was expressed in Pichia pastoris. Purified scFv54.6 recognized native VLPs by immunoblot, inhibited VLP-mediated hemagglutination, and blocked VLP binding to H carbohydrate antigen expressed on the surface of a CHO cell line stably transfected to express α 1,2-fucosyltransferase. Conclusion scFv54.6 retained the functional properties of the parent mAb with respect to inhibiting norovirus particle interactions with cells. With further engineering into a form deliverable to the gut mucosa, norovirus neutralizing antibodies represent a prophylactic strategy that would be valuable in outbreak settings.

  1. Crystal structures of the ScAgSe{sub 2} and Sc{sub 1.02}Cu{sub 0.54}Sn{sub 1.1}S{sub 4} compounds

    Energy Technology Data Exchange (ETDEWEB)

    Shemet, V.Ya. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine); Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@univer.lutsk.ua; Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave 13, 43009 Lutsk (Ukraine)

    2006-12-21

    The crystal structures of the compounds ScAgSe{sub 2} (space group P3-bar m1, a=0.38779 (2)nm, -bar =0.66501 (5)nm, Pearson symbol hP4, R{sub I}=0.0679) and Sc{sub 1.02}Cu{sub 0.54}Sn{sub 1.1}S{sub 4} (space group Fd3-bar m, a=1.04176 (6)nm, Pearson symbol cF53.28, R{sub I}=0.0624) were determined by means of X-ray powder diffraction. The Se atoms in the structure of the ScAgSe{sub 2} compound are stacked in a close-packed arrangement with the layers in the sequence AB. The Sc atoms occupy half of the octahedral interstices, the Ag atoms occupy remaining octahedral interstices. The S atoms of the Sc{sub 1.02}Cu{sub 0.54}Sn{sub 1.1}S{sub 4} compound are stacked in a close-packed arrangement with the layers in the sequence ABC. The atoms of Sc and statistical mixture M (Sc+Sn) are located in all octahedral interstices, the Cu atoms in 1/8 of the tetrahedral interstices.

  2. Parameters of superfine interactions in Laves ScFe sub 2 alloy with hexagonal MnZn sub 2 structure

    CERN Document Server

    Pokatilov, V S

    2001-01-01

    The superfine fields, amplification coefficients and quadrupole splitting on the sup 4 sup 5 Sc nuclei in the ScFe sub 2 , Sc sub 0 sub . sub 9 sub 5 Fe sub 2 sub . sub 0 sub 5 and ScFe sub 1 sub . sub 9 sub 7 Al sub 0 sub . sub 0 sub 3 alloys are measured at the room temperature and 77 K through the method of the nuclear magnetic resonance (NMR). The NMR spectra peculiarities are studied and the superfine field shifts on the sup 4 sup 5 Sc nuclei in the considered alloys by appearance of the Fe atoms at the Sc atoms places and the Al atoms at the Fe atoms places in the Sc atoms nearest coordination sphere are determined. It is established that the electron quadrupole splitting in the considered alloys does not depend on the technology of obtaining the samples, on insignificant deviations from the alloy stoichiometric composition or on the minor additions of the Al atoms

  3. Effects of SC-560 in Combination with Cisplatin or Taxol on Angiogenesis in Human Ovarian Cancer Xenografts

    Directory of Open Access Journals (Sweden)

    Wei Li

    2014-10-01

    Full Text Available This study was designed to evaluate the effect of cyclooxygenase-1 (COX-1 inhibitor, SC-560, combined with cisplatin or taxol, on angiogenesis in human ovarian cancer xenografts. Mice were treated with intraperitoneal (i.p. injections of SC-560 6 mg/kg/day, i.p. injections of cisplatin 3 mg/kg every other day and i.p. injections of taxol 20 mg/kg once a week for 21 days. Vascular endothelial growth factor (VEGF mRNA levels were detected by reverse transcription-polymerase chain reaction (RT-PCR; microvessel density (MVD was determined by immunohistochemistry; and prostaglandin E2 (PGE2 levels were determined using ELISA. Expression levels of VEGF mRNA and MVD in treatment groups were inhibited significantly when compared with the control group (p < 0.05 for all, and SC-560 combined with cisplatin displayed a greater reduction in the expression of VEGF and MVD than SC-560 or cisplatin alone (p < 0.05. SC-560 combined with taxol showed a greater inhibition on VEGF mRNA expression than SC-560 or taxol alone (p < 0.05. The level of PGE2 in treatment groups was significantly reduced when compared with the control group (p < 0.01 for all. These findings may indicate that cisplatin or taxol supplemented by SC-560 in human ovarian cancer xenografts enhances the inhibition effect of cisplatin or taxol alone on angiogenesis.

  4. Development of methods for the selective separation of Sc for use in nuclear medicine

    International Nuclear Information System (INIS)

    Full text of publication follows. Scandium radioisotopes are increasingly finding application in PET imaging or targeted therapy [Ref.1]. They can be produced in a no-carrier-added form through various charged particle reactions using Ti or Ca targets [Refs.1,2]. In order to provide Sc of sufficient quantity and quality, fast and reliable methods for its production are needed, including, depending on the production route, the quantitative recovery of the target material. Extraction chromatographic resins allow an easy adjustment of selectivity, show fast kinetics and high capacity and are thus well suited for fast and selective separations [Ref.3]. The aim of the presented project is the development of methods for the separation of Sc radionuclides from irradiated targets. The development of the methods includes the determination of k' values of Sc, Ca, Ti and other potentially interfering elements and impurities for varying Resins, notably TRU and DGA resin, acids and pH values and the influence of macro amounts of Ti and Ca on the extraction of Sc. Elution studies were performed in order to evaluate best suited rinsing/elution conditions and volumes. Based on the obtained results, methods for the separation of Sc and its purification, from irradiated targets were developed and tested on simulated Ti and Ca targets. In order to further improve the separation new extraction chromatographic resins based on the coated nano-tubes were prepared and tested. The recovery of the target materials will also be addressed. References: [1] K. L. Kolsky, V. Joshi, L. F. Mausner and S. C. Srivastava; Radiochemical Purification of No-carrier- added Scandium-47 for Radioimmunotherapy, Appl. Radiat. Isot. Vol. 49, No. 12, pp. 1541-1549, 1998; [2] Sadeghi, Mahdi; Enferadi, Milad; Aref, Morteza; Jafari, Hoda, Nuclear data for the cyclotron production of 66Ga, 86Y, 76Br, 64Cu and 43Sc in PET imaging, Nukleonika, Volume 55, Issue 3, 293-302 (2010); [3] Horwitz, E.P., McAlister, D

  5. Investigation on Mg and Sc co-doped Ceria electrolyte for IT-SOFC

    Directory of Open Access Journals (Sweden)

    P.Ravi Chandran

    2014-07-01

    Full Text Available Nanocrystalline form of pure ceria (CeO2 and metal (Mg or Sc doped ceria was attempted for 10 mol %. Also, Mg and Sc co-doped ceria with Ce1-x(Mg0.5Sc0.5xO2 (x=0-0.24 was prepared as an electrolyte for intermediate temperature solid oxide fuel cells (IT-SOFCs by co-precipitation method. The synthesized different compositions of pure and doped nanocrystalline powders were then subjected to powder X-ray diffraction (XRD for phase and structural identification. All the nanocrystalline samples were found to be ceria based solid solutions of fluorite type structures. A.C. impedance spectroscopy measurements in the frequency range of 50Hz to 5MHz was carried out to study the grain, grain boundary and ionic conductivity of doped ceria samples in the temperature range of 400-600oC. The sample Ce0.84(Mg0.5Sc0.50.16O2 composition showed highest ionic conductivity i.e., 1.923 x 10-2 S/cm at 500oC. Its morphology and composition was investigated using scanning electron microscopic analysis (SEM and energy dispersive X-ray spectrometry (EDS and conductivity behavior was compared with those of pure ceria and singly doped ceria electrolytes namely Ce0.9Mg0.1O2 and Ce0.9Sc0.1O2. The impedance analysis reveals that the sample Ce0.9Mg0.1O2 was found to have higher ionic conductivity compared to Ce0.9Sc0.1O2 in the temperature range of 400–600°C. The co-doped ceria showed a much higher conductivity in air at 500oC in comparison to that of singly doped ceria. Therefore, these co-doped ceria are also the more ideal electrolyte materials for IT-SOFCs. Nyquist plot shows the major contributions were due to the grain boundary resistance contributions which accounts for the higher ionic conductivity in case of the dopants. These dopant effect on the ceria is discussed in detail.

  6. Synthesis and Reaction of [MnRe(CO)6(μ-SH)(μ-SC(H)PPri3)(PPh3)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The synthesis, the crystal structure and the reaction of the hetero-binuclear complex [MnRe(CO)6(μ-SH)(μ-SC(H)PPri3)(PPh3)] are reported. The results of single crystal X-ray structure analysis showed that the fragments Mn(CO)3 and Re(CO)3 were bridged by SH and SC(H)PPri3. The title complexes can react with BunLi and RX forming complexes MnRe(CO)6(μ-SR)(μ-SC(H)PPri3)(PPh3) (R = Me, CH2CH=CH2, SnBu3n).

  7. Transcriptional stimulation via SC site of Bombyx sericin-1 gene through an interaction with a DNA binding protein SGF-3.

    OpenAIRE

    Matsuno, K.; Takiya, S; Hui, C C; Suzuki, T.; Fukuta, M.; Ueno, K.; Suzuki, Y

    1990-01-01

    Three protein binding sites have been identified in the upstream region of the sericin-1 gene. Two of them, SA and SC sites, have been known as putative cis-acting elements. Using synthetic oligonucleotides of these binding sites, it was found that silk gland factor-1 (SGF-1) binds to the SA site, and silk gland factor-3 (SGF-3) binds to the SC site but not to a mutated SC site, SCM. Tissue distribution of the two factors was different. SGF-3 is present abundantly in the middle silk gland (MS...

  8. MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.

    OpenAIRE

    Marin IONICĂ; Popescu, Marian; Radu TOMESCU

    2012-01-01

    Through this scientific research report “MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.” we plan to investigate the remuneration and stimulation method from the human resources department within S.C. Tasmania. Studying in detail the personnel’s remuneration and stimulation we have tried to present the main policy aspects at S.C. Tasmania in human resources domain: integration of the human resource management in the overall management of the...

  9. Production and characterization of a recombinant anti-MUC1 scFv reactive with human carcinomas.

    OpenAIRE

    Denton, G; Sekowski, M.; Spencer, D. I.; Hughes, O. D.; Murray, A; Denley, H; Tendler, S. J.; Price, M. R.

    1997-01-01

    Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display technology and gene expression systems in E. coli has led to the production of soluble C595 scFv. The scFv has been purified from the bacterial supernatant by peptide epitope affi...

  10. Structural characterization and biological activities of SC4,an acidic polysaccharide from Salvia chinensis%石见穿酸性多糖SC4的结构特征和生物活性

    Institute of Scientific and Technical Information of China (English)

    刘翠平; 方积年; 李晓玉; 萧晓秋

    2002-01-01

    AIM:To study the chemical characterization and some biological activities of an acidic polysaccharide,named SC4 from Salvia chinensis.METHODS:Chemical and spectral methods were employed to identify the structural characterization of SC4.Effect of SC4 on the proliferation of T- and B-lymphocytes both in vivo and in vitro was measured at various concentrations,and the protective effects of SC4 on PC12 cells against H2O2-induced injury was observed.RESULTS:SC4 was a highly branched polysaccharide with mean molecular weight of 4.5 × 105,composed of Rha,Xyl,Set,Gal,and GalA in the molar ratio of 1.0:7.0:5.3:1.2:4.2.Methylation analysis and NMR identified the linkages of the residues of SC4.SC4 increased the B-lymphocyte proliferation and spleen weight remarkably while no obvious changes were examined in T-lymphocyte proliferation,thymus weight,and the level of IgG and C3 in blood of mice.Moreover,SC4 enhanced the PC12 cells viability after H2O2 treatment.CONCLU-SION:SC4,the acidic polysaccharide with complicated structure,was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2-induced injury.%目的:研究从石见穿(Salvia chinensis)中得到的酸性多糖SC4的化学结构和生物活性.方法:利用化学和光谱方法分析了SC4的结构特征,并观察了SC4对淋巴细胞增殖的影响以及增强PC12细胞对抗H2O2造成的损伤的作用.结果:SC4的分子量为4.5×105,由Rha,Xyl,Ser,Gal和GalA组成,摩尔比为1.0:7.0:5.3:1.2:4.2.甲基化和13C NMR进一步确定了SC4中各糖残基的连接方式.SC4能显著促进B淋巴细胞的增殖,增加小鼠脾重,增强PC12细胞对抗H2O2造成的氧化损伤的能力.结论:SC4为一多分枝的酸性多糖,其免疫活性的靶细胞为B淋巴细胞,并显著增强PC12细胞对抗H2O2造成的损伤的能力.

  11. b172sc.m77t - MGD77 data file for Geophysical data from field activity B-1-72-SC in Central California from 11/11/1972 to 11/15/1972

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry, gravity, and magnetics data along with transit satellite navigation data was collected as part of field activity B-1-72-SC in Central...

  12. Generation and Characterization of an scFv Directed against Site II of Rabies Glycoprotein

    Directory of Open Access Journals (Sweden)

    Shukra M. Aavula

    2011-01-01

    Full Text Available Recombinant antibody phage display technology is a vital tool that facilitates identification of specific binding molecules to a target enabling the rapid generation and selection of high affinity, fully human, or mouse antibody product candidates essentially directed towards disease target appropriate for antibody therapy. In this study, a recombinant single-chain Fv antibody fragment (scFv A11 was isolated from immune spleen cells obtained from mice immunized with inactivated rabies virus (Pasteur strain using standard methodology and was characterized for its specificity towards the rabies virus glycoprotein. Epitope mapping using peptide libraries and truncated glycoprotein polypeptides suggested that A11 bound to the antigenic site II of rabies glycoprotein against which a majority of rabies virus neutralizing antibodies are directed. The use of the above technology could, therefore, allow development of scFvs with different specificities against the rabies glycoprotein as an alternative to the more cumbersome protocols used for the development of monoclonal antibodies.

  13. mini Style 松下直板手机SC3评测

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    松下2005年最拉风的产品莫过于6系列和7系列的折叠机.屏幕清晰靓丽.可谓出尽风头。同时.松下还发布了两款低端直板手机.使得产品线更趋丰富,A210和SC3造型小巧到极至.一规矩方正一可爱圆润.是非常不错的学生机。尽管上市有些时日.仍得到用户关注.其中SC3更是得到师哥靓妹的青睐。

  14. Investigation of the microstructure and properties of a friction stir welded Al-Mg-Sc alloy

    Energy Technology Data Exchange (ETDEWEB)

    Lapasset, G.; Boivin, D. [ONERA, Chatillon (France); Girard, Y.; Campagnac, M.H. [EADS-CRC, Suresnes (France)

    2003-07-01

    The objective of this study is to provide a better knowledge of the relationships between microstructural evolution and both mechanical and corrosion properties of a friction stir welded Al-Mg-Sc alloy. Microstructures were studied by optical microscopy, transmission electron microscopy, electron backscattered diffraction and microhardness measurements. Tensile testing was carried out in order to determine the global behaviour of the joint as well as the local behaviour of the main zones of the joint. The weld nugget appears to be the softest zone of the weld. Its undermatching is analyzed with reference to the various hardening contributions of relevance in Al-Mg-Sc alloys. It is tentatively concluded that recrystallization which occurred in the nugget at the expense of the fine unrecrystallized structure of the base metal is primarily responsible for the loss of strength of the joint. Accelerated corrosion tests did not show any evidence of susceptibility to intergranular attack. (orig.)

  15. Supercritical CO2 direct cycle Gas Fast Reactor (SC-GFR) concept.

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Steven Alan; Parma, Edward J., Jr.; Suo-Anttila, Ahti Jorma (Computational Engineering Analysis, Albuquerque, NM); Al Rashdan, Ahmad (Texas A& M University, College Station, TX); Tsvetkov, Pavel Valeryevich (Texas A& M University, College Station, TX); Vernon, Milton E.; Fleming, Darryn D.; Rochau, Gary Eugene

    2011-05-01

    This report describes the supercritical carbon dioxide (S-CO{sub 2}) direct cycle gas fast reactor (SC-GFR) concept. The SC-GFR reactor concept was developed to determine the feasibility of a right size reactor (RSR) type concept using S-CO{sub 2} as the working fluid in a direct cycle fast reactor. Scoping analyses were performed for a 200 to 400 MWth reactor and an S-CO{sub 2} Brayton cycle. Although a significant amount of work is still required, this type of reactor concept maintains some potentially significant advantages over ideal gas-cooled systems and liquid metal-cooled systems. The analyses presented in this report show that a relatively small long-life reactor core could be developed that maintains decay heat removal by natural circulation. The concept is based largely on the Advanced Gas Reactor (AGR) commercial power plants operated in the United Kingdom and other GFR concepts.

  16. Influence of heat treatment on corrosion behaviour of Al-Zn-Mg-Cu-Zr-Sc alloy

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Y.P.; Liu, X.Y.; He, Y.B. [School of Materials Science and Engineering, Central South University, Changsha 410083 (China); Pan, Q.L. [School of Materials Science and Engineering, Central South University, Changsha 410083 (China); Key Laboratory of Nonferrous Materials Science and Engineering, Ministry of Education, Changsha 410083 (China); Li, W.B. [School of Materials Science and Engineering, Central South University, Changsha 410083 (China); School of Civil Engineering, Hunan City University, Yiyang 413000 (China)

    2012-05-15

    Corrosion behaviour of different tempers (namely NA, UA, PA and OA) of Al-Zn-Mg-Cu-Zr-Sc alloy was studied by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), optical microscopy (OM) and transmission electron microscopy (TEM). Over aged (OA) can decrease the susceptibility to exfoliation due to the discontinuous distribution of the {eta} precipitates at the grain boundaries, cause a negative shift of the corrosion potential (E{sub corr}), and lead to the prolonging of the time of the appearance of two time constants in impedance diagrams. In addition, Al-Zn-Mg-Cu-Zr-Sc alloy with over aged treatment has an enhanced resistance to exfoliation corrosion. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. Which Is The Best Sandwich Compound? Hexaphenylbenzene Substituted By Sandwich Compounds Bearing Sc, Cr, and Fe.

    Science.gov (United States)

    Ramos, Estrella; Martínez, Ana; Rios, Citlalli; Salcedo, Roberto

    2015-11-25

    The electronic properties of nine different hexaarylbenzene molecules substituted by sandwich compounds have been studied by applying density functional theory. Different structures and the particular electron donor power of these systems have been considered in order to analyze their oxidant capacity, using bis(ciclopentadienyl) scandium, ferrocene, and bis(benzene)chromium as sandwich compounds. Both monometallic and bimetallic combinations are investigated. According to the ionization energies and electron affinities, compounds with Cr are nucleophiles and represent the best electron donors, whereas compounds with Sc are electrophiles and represent the best electron acceptors. The worse electron donor or acceptor is hexakis(4-ferrocenyl phenyl) benzene. This is very significant, as it implies that the very well-known electronic properties of hexakis(4-ferrocenyl phenyl) benzene can be improved by substituting with other metals, such as Sc and Cr. This suggests several possible applications for these compounds. PMID:26528582

  18. Influencing Factors of Preparation of Al-Mg-Sc Master Alloy

    Institute of Scientific and Technical Information of China (English)

    Zhang Jun; Zhang Zonghua; Zhang Guifang

    2007-01-01

    Through the experiment, the reduced temperature, the containing scandium quantity of the fused salt, the agitated intensity and the restoring time that influence the rate of receives of scandium, and determined the technological conditions which uses the method of hot Al-Mg restoring anhydrous the chloride of scandium to prepare the Al-Mg-Sc master alloy. The best experimental technological conditions are that the master alloy can contains 8.0% of scandium while the restoring temperature is at 900℃, the restoring time is 20min and the agitated time is a half minute. When the method of the fused salt covered with bell, agitated and pressed the argon is used in the expansion tests, the agitated number is 4 times and the average receives rate of Sc is 90.0%.

  19. : Les mises en scène audiovisuelles des fusillades dans les écoles

    OpenAIRE

    Paton, Nathalie; Figeac, Julien

    2015-01-01

    International audience Le présent article décrit la façon dont les auteurs de fusillades dans les écoles ont pu diffuser des vidéos, avant de passer à l'acte, grâce aux ressources des médias participatifs. Ces personnes tentent de « préméditer » leur tuerie en proposant aux entreprises de presse des scénarisations audiovisuelles de leur identité et de leur projet meurtrier. L'analyse détaillée de ces scénarisations révèle comment elles exploitent les ressorts performatifs de slogans ou de ...

  20. Improving SC-FDMA performance by Turbo Equalization in UTRA LTE Uplink

    DEFF Research Database (Denmark)

    Berardinelli, Gilberto; Priyanto, Basuki Endah; Sørensen, Troels Bundgaard;

    2008-01-01

    Turbo equalization is known as an advanced iterative equalization and decoding technique that allows to enhance the performance of the data transmission over a frequency selective fading channel. The turbo equalizer will result in extra receiver complexity, but isolated to the base-station, which...... does not have stringent power constraints. In this paper, a turbo equalization technique to improve Single Carrier Frequency Division Multiple Access (SC-FDMA) performance is proposed. A new adaptive coefficients solution for frequency domain equalization is considered. The work is in the context...... that the turbo equalizer can improve the BLER performance around 1 dB with only a few iterations, and improve the SC-FDMA performance over OFDM, especially at high coding rate....

  1. Atomic physics modeling of transmission spectra of Sc-doped aerogel foams to support OMEGA experiments

    Science.gov (United States)

    Johns, H. M.; Lanier, N. E.; Kline, J. L.; Fontes, C. J.; Perry, T. S.; Fryer, C. L.; Brown, C. R. D.; Morton, J. W.; Hager, J. D.; Sherrill, M. E.

    2016-11-01

    We present synthetic transmission spectra generated with PrismSPECT utilizing both the ATBASE model and the Los Alamos opacity library (OPLIB) to evaluate whether an alternative choice in atomic data will impact modeling of experimental data from radiation transport experiments using Sc-doped aerogel foams (ScSi6O12 at 75 mg/cm3 density). We have determined that in the 50-200 eV Te range there is a significant difference in the 1s-3p spectra, especially below 100 eV, and for Te = 200 eV above 5000 eV in photon energy. Examining synthetic spectra generated using OPLIB with 300 resolving power reveals spectral sensitivity to Te changes of ˜3 eV.

  2. Validation of the ATHLET-SC code by trans-critical transient data

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiaojing; Cheng, Xu [Shanghai Jiao Tong Univ. (China). School of Nuclear Science and Engineering

    2016-05-15

    For the safety analysis of Supercritical Water-Cooled Reactor (SCWR), one of the challenge tasks is to predict the trans-critical behavior of the reactor system during some accidents. The current safety codes have some shortcomings when the pressure decreases from the supercritical condition to the subcritical state due to the void fraction discontinuity across the critical point. Another challenge is the validation of the system code, which needs the transient experimental data. To overcome the above-mentioned challenges, this paper validates the modified code ATHLET-SC, which is developed based on the pseudo two-phase method. The trans-critical transient data from SWAMUP test facility in Shanghai Jiao Tong University (SJTU) are adopted to compare with the simulation results. The results obtained so far shows that the ATHLET-SC code has good feasibility to the trans-critical simulation of SCWR, and it can be used for transient analysis of SCWR in the future.

  3. The Surface Properties of PAVAc Prepared by Dispersion Polymerization in ScCO2

    Institute of Scientific and Technical Information of China (English)

    YANG Ya-jun; WANG Zi; HU Chun-pu; DONG Qing-zhi

    2008-01-01

    Dispersion copolymerization of acrylonitrile-vinyl acetate (AN-VAc) has been successfully performed in supercritical carbon dioxide (ScCO2) with a series of lipophilic/CO2-philic diblock copolymers, such as poly (styrener-acrylonitrile)-b-poly (1, 1, 2, 2-tetrahydroperfluorooctyl methacrylate) (PSAN-b-PFOMA), as steric stabilizers. The structure and the particle morphology of the product were characterised by FT-IR and SEM. In addition, the effects of the stabilizer on the surface properties of the products were investigated in detail. Results indicate that the surface free energy of the poly (AN-r-VAc) (PAVAc) film decreases dramatically because of the existence of the stabilizer. And, when the initial concentration of the monomer was 10% (the mass (g) of monomer to the volume (mL) of ScCO2) the optimal concentration of the stabilizer is about 5% (w/w% to monomers).

  4. Structural characterization and ytterbium spectroscopy in Sc{sub 2}O{sub 3} nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Galceran, M. [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain); Pujol, M.C., E-mail: mariacinta.pujol@urv.ca [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain); Carvajal, J.J.; Mateos, X. [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain); Zaldo, C. [Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientificas (CSIC), c/ Sor Juana Ines de la Cruz 3, E-28049 Madrid (Spain); Aguilo, M.; Diaz, F. [Fisica i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA), Universitat Rovira i Virgili (URV), Campus Sescelades, c/ Marcel. li Domingo, s/n, E-43007 Tarragona (Spain)

    2010-08-15

    Ytterbium-doped scandium oxide nanocrystals measuring less than 25 nm with compositions of Sc{sub 2-x}Yb{sub x}O{sub 3} (x=0.001-1) were prepared using the modified Pechini method. The Yb:Sc{sub 2}O{sub 3} nanocrystals were obtained by calcination at low temperature such as 1073 K for 2 h. X-ray powder diffraction (XRD) and transmission electronic microscopy (TEM) were used to perform the structural characterization of nanocrystals; these studies indicated that the nanocrystals have high crystalline quality with cubic structure and Ia3-bar space group. The morphology and particle size were studied using electron microscopy. A detailed study of the effect of the nanodimension and the ytterbium concentration on the spectroscopic characteristics of Yb{sup 3+} as an active ion was carried out in terms of optical absorption, optical emission and fluorescence decay time at room and low temperature.

  5. Electronic structure and binding energy relaxation of ScZr atomic alloying

    Science.gov (United States)

    Bo, Maolin; Guo, Yongling; Yang, Xuexian; He, Junjie; Liu, Yonghui; Peng, Cheng; Huang, Yongli; Sun, Chang Q.

    2016-07-01

    We examined the combined effect of atomic under- and hetero-coordination on the bond relaxation and electronic binding energy of Sc, Zr, and ScZr alloying using a combination of the bond-order-length-strength (BOLS) correlation and density functional theory (DFT) calculations. Observations strongly emphasize the relevance of core-level shifts as reliable X-ray photoelectron spectroscopy experimental descriptors of core-shell catalysis reactivity, along with under-coordinated atoms in bimetallic transition metal systems. The BOLS-DFT method provides enhanced catalysis reactivity and detects surface and alloy configurations, opening up the possibility to investigate more complex systems with irregularly under- and hetero-coordinated atoms.

  6. Theoretical Calculations of Transition Probabilities and Oscillator Strengths for Sc(Ⅲ) and Y(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    Tian-yi Zhang; Neng-wu Zheng

    2009-01-01

    The Weakest Bound Electron Potential Model theory is used to calculate transition probability-values and oscillator strength-values for individual lines of Sc(Ⅲ) and Y(Ⅲ). In this method, by solving the SchrSdinger equation of the weakest bound electron, the expressions of energy eigenvalue and the radial function can be obtained. And a coupled equation is used to determine the parameters which are needed in the calculations. The ob-tained results of Sc(Ⅲ) from this work agree very well with the accepted values taken from the National Institute of Standards and Technoligy (NIST) data base, most deviations are within the accepted level. For Y(Ⅲ) there are no accepted values reported by the NIST data base. So we compared our results of Y(Ⅲ) with other theoretical results, good agreement is also obtained.

  7. Special Issue: SC13 – The International Conference for High Performance Computing, Networking, Storage and Analysis

    Directory of Open Access Journals (Sweden)

    William Gropp

    2014-01-01

    Full Text Available The technical papers program for SC13 received 449 submissions of which 90 where selected for the program giving an acceptance rate of 20%. A rigorous peer review process, including author rebuttals and a 1.5 day face-to-face program committee meeting ensured that selected papers were the very best in our field. One of the tasks at the face-to-face meeting was also to select finalists for the best paper award, from which one is selected by a committee during the conference. To further highlight their achievement of being selected as the very top tier of all the submitted papers to SC13, the authors of these finalist papers were offered the opportunity to publish extended versions of their papers in this special issue journal; all eight authors accepted.

  8. On the Perils of Hyperfine Splitting A reanalysis of Mn and Sc Abundance Trends

    CERN Document Server

    Prochaska, J X; Prochaska, Jason X.; William, Andrew Mc

    2000-01-01

    We investigate the impact of hyperfine splitting on stellar abundance analyses of Mn and Sc, and find that incorrect hfs treatment can lead to spurious abundance trends with metallicity. We estimate corrections to a recent study by Nissen et al. (2000), and find: (1) [Mn/Fe] is described by a bimodal distribution, with [Mn/Fe] ~ -0.3 for stars [Fe/H] < -0.7, and [Mn/Fe] ~ -0.05 for stars at higher metallicity, suggestive of a transition between halo/thick disk and thin disk populations. (2) The large majority of stars show nearly solar [Sc/Fe] ratios; although important deviations cannot be ruled-out.

  9. Nanotec推出SC3518步进电机

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    近来,Nanotec推出SC3518步进电机,不仅具有非常大的扭矩,还具有良好的EMC特性。SC3518系列电机是两相混合式步进电机、大小为NEMA14(35mm),具有1.8°的步距角。根据电机长度的不同,其扭矩在0.18-0.32Nm之间。步进电机通过一个集成连接器连接,可轻松适应用户应用的任何电缆。

  10. Validation of the ATHLET-SC code by trans-critical transient data

    International Nuclear Information System (INIS)

    For the safety analysis of Supercritical Water-Cooled Reactor (SCWR), one of the challenge tasks is to predict the trans-critical behavior of the reactor system during some accidents. The current safety codes have some shortcomings when the pressure decreases from the supercritical condition to the subcritical state due to the void fraction discontinuity across the critical point. Another challenge is the validation of the system code, which needs the transient experimental data. To overcome the above-mentioned challenges, this paper validates the modified code ATHLET-SC, which is developed based on the pseudo two-phase method. The trans-critical transient data from SWAMUP test facility in Shanghai Jiao Tong University (SJTU) are adopted to compare with the simulation results. The results obtained so far shows that the ATHLET-SC code has good feasibility to the trans-critical simulation of SCWR, and it can be used for transient analysis of SCWR in the future.

  11. [Human amniotic epithelium (HAE) as a possible source of stem cells (SC)].

    Science.gov (United States)

    García-López, Guadalupe; García-Castro, Irma Lydia; Avila-González, Daniela; Molina-Hernández, Anayansi; Flores-Herrera, Héctor; Merchant-Larios, Horacio; Díaz-Martínez, Fabián

    2015-01-01

    There have been major recent advances in the field of developmental biology due to the investigation on stem cells (SC). Stem cells are characterized by their capacity of auto-renewal and differentiation to different cellular phenotypes. Based on the developmental stage, they can be classified into two different types: embryonic SCs and adult SCs. It has been widely reported that several problems need to be resolved before their possible clinical applications. As a result, fetal membranes have been suggested as an alternative source of SCs. In the human amniotic epithelium, the presence of markers of pluripotent SC´s has been reported, and its capacity as a feeder layer for expansion of different SC types. Also, fetal membranes are a discarded product after delivery, and thus there are not any ethical issues related to its use. In conclusion, the human amniotic epithelium can be a strong candidate for regenerative medicine.

  12. Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease.

    Science.gov (United States)

    Squiers, John J; Edwards, Anthony G; Parra, Alberto; Hofmann, Sandra L

    2016-01-01

    A 70-year-old African American female with a past medical history significant for chronic bilateral shoulder pain and reported sickle cell trait presented with acute-onset bilateral thoracolumbar pain radiating to her left arm. Two days after admission, Hematology was consulted for severely worsening microcytic anemia and thrombocytopenia. Examination of the patient's peripheral blood smear from admission revealed no cell sickling, spherocytes, or schistocytes. Some targeting was noted. A Coombs test was negative. The patient was eventually transferred to the medical intensive care unit in respiratory distress. Hemoglobin electrophoresis confirmed a diagnosis of hemoglobin SC disease. A diagnosis of acute splenic sequestration crisis complicated by acute chest syndrome was crystallized, and red blood cell exchange transfusion was performed. Further research is necessary to fully elucidate the pathophysiology behind acute splenic sequestration crisis, and the role of splenectomy to treat hemoglobin SC disease patients should be better defined. PMID:27047980

  13. Three-phase-boundary dynamics at the Ni/ScYSZ interface

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hansen, Karin Vels; Norrman, Kion;

    2009-01-01

    Chronoamperometry using a three-electrode cell configuration was undertaken with a nickel point-electrode acting as the working electrode on a polished ScYSZ electrolyte in a hydrogen atmosphere at 750–850 °C. High anodic overpotentials resulted in the occurrence of distinct sawtooth oscillation ...... of the current oscillations. A mechanism accounting for the observed phenomena and possible implications for solid oxide fuel cell operation are presented...

  14. Molecular dynamics simulations of the hydrophobin SC3 at a hydrophobic/hydrophilic interface

    OpenAIRE

    Fan, Hao; Wang, Xiaoqin; Zhu, Jiang; Robillard, George T.; Mark, Alan E.

    2006-01-01

    Hydrophobins are small (similar to 100 aa) proteins that have an important role in the growth and development of mycelial fungi. They are surface active and, after secretion by the fungi, self-assemble into amphipathic membranes at hydrophobic/hydrophilic interfaces, reversing the hydrophobicity of the surface. In this study, molecular dynamics simulation techniques have been used to model the process by which a specific class I hydrophobin, SC3, binds to a range of hydrophobic/ hydrophilic i...

  15. Thermodynamic modeling of the RE–Pb (RE = Sc, Dy, Gd) systems

    Energy Technology Data Exchange (ETDEWEB)

    Iddaoudi, A., E-mail: iddaoudi19@gmail.com [Laboratoire de Thermodynamique et Energétique, LTE, Université Ibn-Zohr, B.P. 8106 Agadir (Morocco); Servant, C., E-mail: colette.servant@orange.fr [Laboratoire de Physicochimie de l’Etat Solide, ICMMO, Université Paris-Sud, 91405 Orsay Cedex (France); Selhaoui, N.; Kardellass, S.; Mahdouk, K.; Bouirden, L. [Laboratoire de Thermodynamique et Energétique, LTE, Université Ibn-Zohr, B.P. 8106 Agadir (Morocco)

    2014-03-15

    Highlights: • Rare earth (RE) and Pb alloys or compounds are interesting as magnetic materials. • The phase diagrams and thermodynamic properties of RE–Pb (RE = Sc, Dy, Gd) systems have been assessed. • The CALPHAD method was used with the Redlich–Kister model to optimize the solution phases. • A self-consistent set of thermodynamic parameters has been evaluated. • A good agreement was found between the calculation and experiments. -- Abstract: The phase diagrams and thermodynamic properties of RE–Pb (RE = Sc, Dy, Gd) systems have been assessed by means of the CALPHAD method. The solution phases (liquid, fcc, bcc and hcp) were described by the sublattice formalism and the excess term of the Gibbs energy with the Redlich–Kister equation. The stoichiometric intermetallic compounds (Sc{sub 5}Pb{sub 3}, Sc{sub 6}Pb{sub 5}, Dy{sub 5}Pb{sub 4}, DyPb, DyPb{sub 2}, DyPb{sub 3}, β-Gd{sub 5}Pb{sub 4}, α-Gd{sub 5}Pb{sub 4}, Gd{sub 11}Pb{sub 10}, Gd{sub 6}Pb{sub 7}, GdPb{sub 2} and GdPb{sub 2}) were modeled as line compounds. The non-stoichiometric Dy{sub 5}Pb{sub 3} and Gd{sub 5}Pb{sub 3} phases with a narrow homogeneity range were modeled using a two-sublattice model with substitution. A consistent set of the thermodynamic parameters leading to a reasonable agreement between the calculated results and literature data was obtained.

  16. Comparison of three microbial hosts for the expression of an active catalytic scFv.

    Science.gov (United States)

    Robin, Sylvain; Petrov, Kliment; Dintinger, Thierry; Kujumdzieva, Anna; Tellier, Charles; Dion, Michel

    2003-01-01

    Antibodies represent an interesting protein framework on which catalytic functions can be grafted. In previous studies, we have reported the characterization of the catalytic antibody 4B2 obtained on the basis of the "bait and switch" strategy which catalyzes two different chemical reactions: the allylic isomerization of beta,gamma-unsaturated ketones and the Kemp elimination. We have cloned the antibody 4B2 and expressed it as a single-chain Fv (scFv) fragment in different expression systems, Escherichia coli and two yeasts species, in order to elicit the most suitable system to study its catalytic activity. The scFv4B2 was secreted as an active form in the culture medium of Pichia pastoris and Kluyveromyces lactis, which led respectively to 4 and 1.3mg/l after purification. In E. coli, different strategies were investigated to increase the cytoplasmic soluble fraction, which resulted, in all cases, in the expression of a low amount of functional antibodies. By contrast, substantial amount of scFv4B2 could be purified when it was expressed as inclusion bodies (12mg/l) and submitted to an in vitro refolding process. Its catalytic activity was measured and proved to be comparable to that of the whole IgG. However, the instability of the scFv4B2 in solution prevented from an exhaustive characterization of its activity and stabilization of this protein appears to be essential before designing strategies to improve its catalytic activity. PMID:12531284

  17. Solid Waste in Drainage Network of Rio do Meio Watershed, Florianópolis/SC

    OpenAIRE

    Taiana Gava; Alexandra Rodrigues Finotti

    2012-01-01

    The urban drainage network is among the main pollution transport load factors. Researches on the identification of solid waste transported in the drainage network have been considered the allow evaluation of its impact. In this paper we analyze the main characteristics that influences the presence of solid wastes in the drainage network of the Rio do Meio basin, Florianópolis/SC. A metal net was installed in selected river section and monitored after each rain event. The results showed about ...

  18. Apparent vanishing of ferroelectricity in nanostructured BiScO3PbTiO3

    OpenAIRE

    Amorín, H.; R. Jiménez; Ricote, J.; Hungría, T; de Castro, A.; Algueró, M.

    2010-01-01

    Abstract Nanostructured ceramics of high-temperature piezoelectric 0.375BiScO 3 -0.625PbTiO 3 were prepared by spark plasma sintering of nanocrystalline powders obtained by mechanosynthesis. The macroscopic electrical properties were characterized on dense ceramics with decreasing average grain size down to 28 nm. Results indicate that the electric field is screened by the electrically insulating grain boundaries at the nanoscale, which needs to be considered when discussing size effects i...

  19. Experimental Investigation of Electrical Conductivity and Permittivity of SC-TiO 2 -EG Nanofluids.

    Science.gov (United States)

    Fal, Jacek; Barylyak, Adriana; Besaha, Khrystyna; Bobitski, Yaroslav V; Cholewa, Marian; Zawlik, Izabela; Szmuc, Kamil; Cebulski, Józef; Żyła, Gaweł

    2016-12-01

    The paper presents experimental studies of dielectric properties of nanofluids based on ethylene glycol and SC-TiO2 nanoparticles with average size of 15-40 nm with various mass concentrations. The dielectric permittivity both real part and imaginary part as a function of temperature and frequency were measured. Also, dependence ac conductivity on frequency, temperature, and mass concentration were investigated. Based on the curves of ac conductivity, dc conductivity was calculated, and 400 % enhancement in dc conductivity was exposed.

  20. First-principles investigation on the elastic stability and thermodynamic properties of Ti2SC

    Institute of Scientific and Technical Information of China (English)

    Yang Ze-Jin; Guo Yun-Dong; Linghu Rong-Feng; Cheng Xin-Lu; Yang Xiang-Dong

    2012-01-01

    Using Vanderbilt-type plane-wave ultrasoft pseudopotentials within the generalized gradient approximation(GGA)in the frame of density functional theory(DFT),we have investigated the crystal structures,elastic,and thermodynamic properties for Ti2SC under high temperature and high pressure.The calculated pressure dependence of the lattice volume is in excellent agreement with the experimental results.The calculated structural parameter of the Ti atom experienced a subtle increase with applied pressures and the increase suspended under higher pressures.The elastic constants calculations demonstrated that the crystal lattice is still stable up to 200 CPa.Investigations on the elastic properties show that the c axis is stiffer than the a axis,which is consistent with the larger longitudinal elastic constants(C3s,C11)relative to transverse ones(C44,C12,C13).Study on Poisson's ratio confirmed that the higher ionic or weaker covalent contribution in intra-atomic bonding for Ti2SC should be assumed and the nature of ionic increased with pressure.The ratio(B/G)of bulk(B)and shear(G)moduli as well as B/C44 demonstrated the brittleness of Ti2SC at ambient conditions and the brittleness decreased with pressure.Moreover,the isothermal and adiabatic bulk moduli displayed opposite temperature dependence under different pressures.Again,we observed that the Debye temperature and Griineisen parameter show weak temperature dependence relative to the thernal expansion coefficient,entropy,and heat capacity,from which the pressure effects are clearly seen.

  1. Marketing plan for a new service product - case Spain Internship SC

    OpenAIRE

    Leinonen, Annika

    2015-01-01

    This thesis was conducted for Spain Internship SC which provides global internship solutions for students and companies The purpose of the thesis was to study the marketing planning process and conduct a realistic and functioning marketing plan for the company's new service product, a study and internship program in Canada, and find the best way to promote it for Finnish students and recent graduates. The purpose was also to measure the interest of the target market towards this kind of servi...

  2. Validity Evidence of the Z-Test-SC for Use With Children

    OpenAIRE

    Anna Elisa de Villemor-Amaral; Pâmela Malio Pardini Pavan; Raquel Rossi Tavella; Lucila Moraes Cardoso; Fabiola Cristina Biasi

    2016-01-01

    Abstract In Brazil, there is a lack of tools to assess the children's affective and cognitive dynamics and investments are needed in research that seeks evidence of validity of some assessment tools for that public. The Zulliger test in the Comprehensive System (Zulliger-SC) evaluates the adequacy of reality perception, affects, self-perception, interpersonal relationship and cognitive processing and can be used with children, although there are few studies with this purpose in Brazil. Thus, ...

  3. Artemisinin content of sc-C0₂ derived extracts from Artemisia annua / Surisha Padayatchi.

    OpenAIRE

    Padayatchi, Surisha

    2004-01-01

    One of the principal research themes of the supercritical fluid research group within the Centre of Separation Science and Technology (SST) at the North-West University (Potchefstroom Campus) is botanical extraction. The group produces botanical extracts from locally cultivated plants which contain substances (essential oils, natural waxes) relevant to the food, flavour, pharmaceutical, medical and cosmetic industries while utilising the advantages of sc-C& extraction over traditi...

  4. Fatal pulmonary thromboembolism associated with hemoglobin SC disease in a 15 year-old boy

    Directory of Open Access Journals (Sweden)

    Thiago Trolez Amancio

    2011-09-01

    Full Text Available We report a case of hemoglobin SC disease complicated by fatal pulmonarythromboembolism in a 15 year-old Brazilian boy, submitted to autopsy. Thiscase shows the importance of early diagnosis and treatment of sickle celldisease, which generates systemic involvement in youth and the importanceof considering the hypercoagulability in these patients. The autopsy was veryinstructive, revealing the florid morphologic aspect of sickle cell disease andits complications.

  5. Efficacy of IGR compound Starycide 480 SC (Triflumuron) against mosquito larvae in clear and polluted water

    OpenAIRE

    C.P. Batra, P.K. Mittal, T. Adak & M.A. Ansari

    2005-01-01

    Background & objectives: An environmental friendly formulation Starycide 480 SC (Triflumuron–OMS-2015 ), a new insect growth regulator with chitin synthesis inhibitor type mode of action wasevaluated against mosquito larvae in laboratory and small-scale field trials carried out in and aroundDelhi.Methods: The formulation was tested in laboratory for its bio-efficacy against late III instar mosquitolarvae of different species using WHO bioassay procedure. In the field formulation was sprayed a...

  6. Measuring social capital through multivariate analyses for the IQ-SC

    OpenAIRE

    Campos, Ana Cristina Viana; Borges, Carolina Marques; Vargas, Andréa Maria Duarte; Gomes, Viviane Elisangela; Lucas, Simone Dutra; Ferreira e Ferreira, Efigênia

    2015-01-01

    Background Social capital can be viewed as a societal process that works toward the common good as well as toward the good of the collective based on trust, reciprocity, and solidarity. Our study aimed to present two multivariate statistical analyses to examine the formation of latent classes of social capital using the IQ-SC and to identify the most important factors in building an indicator of individual social capital. Findings A cross-sectional study was conducted in 2009 among working ad...

  7. A first-principle study on the properties of a new series of quaternary Heusler alloys CoFeScZ (Z=P, As, Sb)

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Qiang; Li, Lei; Lei, Gang; Deng, Jian-Bo; Hu, Xian-Ru, E-mail: huxianru@lzu.edu.cn

    2015-04-01

    The electronic structures and magnetic properties of a new series of quaternary Heusler alloys CoFeScZ (Z=P, As, Sb) are investigated through first-principle calculations. CoFeScP is found to have half-metallic ferromagnetism with a large half-metallic gap of 0.60 eV. The results show that both CoFeScAs and CoFeScSb are nearly half-metal under the equilibrium lattice constants. The change of the properties of CoFeScAs and CoFeScSb with pressure is investigated. - Highlights: • Investigate a new series of quaternary Heusler alloys CoFeScZ (Z=P, As, Sb). • The band gap of the half-metal CoFeScP is very large. • Study the magnetic properties and electronic structure of CoFeScP under the equilibrium lattice constant. • Investigate the influence of pressure on the magnetic properties and electronic structure of CoFeScAs and CoFeScSb.

  8. (Cyclopentadienylamine)scandium(2,3-dimethyl-1,3-butadiene) : A 1,3-diene complex of scandium with Sc(I)- and Sc(III)-like reactivity

    NARCIS (Netherlands)

    Beetstra, D.J.; Meetsma, A.; Hessen, B.; Teuben, J.H

    2003-01-01

    The scandium 2,3-dimethyl-1,3-butadiene complex [eta(5),eta(1)-C5H4(CH2)(2)NMe2]Sc(C6H10) (2) reacts with PhCN via initial nitrile insertion into the Sc-diene bond to give a dimeric mu(2)-imido species, but with a 2,2'-bipyridine via the elimination of the free diene. The latter shows that 2 can be

  9. Selection of affinity-improved neutralizing human scFv against HBV PreS1 from CDR3 VH/VL mutant library.

    Science.gov (United States)

    Chen, YanMin; Bai, Yin; Guo, XiaoChen; Wang, WenFei; Zheng, Qi; Wang, FuXiang; Sun, Dejun; Li, DeShan; Ren, GuiPing; Yin, JieChao

    2016-07-01

    A CDR3 mutant library was constructed from a previously isolated anti-HBV neutralizing Homo sapiens scFv-31 template by random mutant primers PCR. Then the library was displayed on the inner membrane surface in Escherichia coli periplasmic space. Seven scFv clones were isolated from the mutant library through three rounds of screening by flow cytometry. Competition ELISA assay indicates that isolated scFv fragments show more efficient binding ability to HBV PreS1 compared with parental scFv-31. HBV neutralization assay indicated that two clones (scFv-3 and 59) show higher neutralizing activity by blocking the HBV infection to Chang liver cells. Our method provides a new strategy for rapid screening of mutant antibody library for affinity-enhanced scFv clones and the neutralizing scFvs obtained from this study provide a potential alternative of Hepatitis B immune globulin.

  10. Selection of affinity-improved neutralizing human scFv against HBV PreS1 from CDR3 VH/VL mutant library.

    Science.gov (United States)

    Chen, YanMin; Bai, Yin; Guo, XiaoChen; Wang, WenFei; Zheng, Qi; Wang, FuXiang; Sun, Dejun; Li, DeShan; Ren, GuiPing; Yin, JieChao

    2016-07-01

    A CDR3 mutant library was constructed from a previously isolated anti-HBV neutralizing Homo sapiens scFv-31 template by random mutant primers PCR. Then the library was displayed on the inner membrane surface in Escherichia coli periplasmic space. Seven scFv clones were isolated from the mutant library through three rounds of screening by flow cytometry. Competition ELISA assay indicates that isolated scFv fragments show more efficient binding ability to HBV PreS1 compared with parental scFv-31. HBV neutralization assay indicated that two clones (scFv-3 and 59) show higher neutralizing activity by blocking the HBV infection to Chang liver cells. Our method provides a new strategy for rapid screening of mutant antibody library for affinity-enhanced scFv clones and the neutralizing scFvs obtained from this study provide a potential alternative of Hepatitis B immune globulin. PMID:27255707

  11. Mechanical, electronic, optical, thermodynamic properties and superconductivity of ScGa{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Parvin, F. [Department of Physics, Rajshahi University, Rajshahi (Bangladesh); Hossain, M.A. [Department of Physics, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902 (Bangladesh); Ali, M.S. [Department of Physics, Rajshahi University, Rajshahi (Bangladesh); Islam, A.K.M.A., E-mail: azi46@ru.ac.bd [International Islamic University Chittagong, 154/A College Road, Chittagong 4203 (Bangladesh)

    2015-01-15

    The rare occurrence of type-I superconductivity in binary system ScGa{sub 3} has experimentally been shown recently. In the present paper we study the electronic, optical, thermodynamic properties and some aspects of superconductivity of this compound using first-principles calculations. The mechanical properties like elastic constants, bulk modulus, shear modulus, Pugh's ductility index, Young's modulus, Poisson's ratio, elastic anisotropy factor, Peierls stress are calculated for the first time. The material is anisotropic and brittle. Electronic band structure, density of states, Fermi surfaces and bonding nature have also been studied. The optical functions are estimated and discussed for the first time. The high reflectivity is found in the ultraviolet regions up to ∼13 eV and thus ScGa{sub 3} can serve as a possible shielding material for ultraviolet radiation. Thermal effects on some macroscopic properties of ScGa{sub 3} are predicted using the quasi-harmonic Debye model and phonon approximation in the temperature and hydrostatic pressure in the ranges of 0–1000 K and 0–40 GPa, respectively. The calculated electron–phonon coupling constant λ=0.52 yields T{sub c}=2.6 K, which is in very good agreement with the experimentally observed value. The value of the coupling constant and the Ginzburg–Landau parameter (κ=0.09) indicate that the compound is a weak-coupled type-I rare binary BCS superconductor.

  12. Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease

    Directory of Open Access Journals (Sweden)

    J. H. Gillis

    2015-01-01

    Full Text Available Acute sickle hepatic crisis (ASHC has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease.

  13. Spectroscopic characterization of Yb:Sc2O3 transparent ceramics

    Institute of Scientific and Technical Information of China (English)

    Lu Shen-Zhou; Yang Qiu-Hong

    2012-01-01

    Yb:Sc2O3 transparent ceramics are fabricated by a conventional ceramic process and sintering in H2 atmosphere.The room-temperature spectroscopic properties are investigated,and the Raman spectrum shows an obvious vibration characteristic band centred at 415 cm-1. There are three broad absorption bands around 891,937,and 971 nm,respectively.The strongest emission peak is centred at 1.04 μm with a broad bandwidth (11 nm) and an emission cross-section of 1.8× 10-20 cm2.The gain coefficient implies a possible laser ability in a range from 990 nm to 1425 nm.The energy-level structure shows that Yb:Sc2O3 ceramics have large Stark splitting at the ground state level due to their strong crystal field.All the results show that Yb:Sc2Oa transparent ceramics are a promising material for short pulse lasers.

  14. Cloning, expression, purification, and characterization of LC-1 ScFv with GFP tag

    Institute of Scientific and Technical Information of China (English)

    LU Min; GONG Xing-guo; YU Hong; LI Jian-yong

    2005-01-01

    Total RNA was isolated from the hybridoma cell line (LC-1), which secretes anti-lung adenocarcinoma monoclonal antibody, and was transferred into cDNA. Based on the FR1 (framework region 1) and FR4 conserved regions of LC-I gene, the variable regions of heavy chain (Vh) and light chain (Vl) were amplified, and the Vh and modified Vl were connected to single chain Fv (ScFv) by SOE-PCR (splice overlap extension PCR). The modified ScFv was fused with green fluorescent protein (GFP)and introduced into E. coli JMi09. The fusion protein induced by IPTG (Isopropylthiogalactoside) was about 57000 on a 10%SDS-PAGE gel (10% Sds Polyacrylamide Gel Electrophoresis), and primarily manifested as inclusion bodies. The renatured protein purified by Ni-NTA Superflow resins showed ability to bind to antigen on SPC-A-1 lung adenocarcinoma. In addition, the induced host cells fluoresced bright green under 395 nm wavelength, which indicated that the expected protein with dual activity was expressed in the prokaryotic system. The ScFv with GFP tag used in this research can be applied as a new reagent to detect immunological dye, and provide a feasible way to detect adenocarcinoma in a clinical setting.

  15. Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies.

    Science.gov (United States)

    Stöger, E; Vaquero, C; Torres, E; Sack, M; Nicholson, L; Drossard, J; Williams, S; Keen, D; Perrin, Y; Christou, P; Fischer, R

    2000-03-01

    This report describes the stable expression of a medically important antibody in the staple cereal crops rice and wheat. We successfully expressed a single-chain Fv antibody (ScFvT84.66) against carcinoembryonic antigen (CEA), a well characterized tumor-associated marker antigen. scFv constructs were engineered for recombinant antibody targeting to the plant cell apoplast and ER. Up to 30 microg/g of functional recombinant antibody was detected in the leaves and seeds of wheat and rice. We confirmed that transgenic dry seeds could be stored for at least five months at room temperature, without significant loss of the amount or activity of scFvT84.66. Our results represent the first transition from model plant expression systems, such as tobacco and Arabidopsis, to widely cultivated cereal crops, such as rice and wheat, for expression of an antibody molecule that has already shown efficacy in clinical applications. Thus, we have established that molecular pharming in cereals can be a viable production system for such high-value pharmaceutical macromolecules. Our findings provide a strong foundation for exploiting alternative uses of cereal crops both in industrialized and developing countries.

  16. EMP Attachment 3 DOE-SC PNNL Site Dose Assessment Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F.

    2011-12-21

    This Dose Assessment Guidance (DAG) describes methods to use to determine the Maximally-Exposed Individual (MEI) location and to estimate dose impact to that individual under the U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Site Environmental Monitoring Plan (EMP). This guidance applies to public dose from radioactive material releases to the air from PNNL Site operations. This document is an attachment to the Pacific Northwest National Laboratory (PNNL) Environmental Monitoring Plan (EMP) and describes dose assessment guidance for radiological air emissions. The impact of radiological air emissions from the U.S. Department of Energy Office of Science (DOE-SC) PNNL Site is indicated by dose estimates to a maximally exposed member of the public, referred to as the maximally exposed individual (MEI). Reporting requirements associated with dose to members of the public from radiological air emissions are in 40 CFR Part 61.94, WAC 246-247-080, and DOE Order 458.1. The DOE Order and state standards for dose from radioactive air emissions are consistent with U.S. Environmental Protection Agency (EPA) dose standards in 40 CFR 61.92 (i.e., 10 mrem/yr to a MEI). Despite the fact that the current Contract Requirements Document (CRD) for the DOE-SC PNNL Site operations does not include the requirement to meet DOE CRD 458.1, paragraph 2.b, public dose limits, the DOE dose limits would be met when EPA limits are met.

  17. Doping of BiScO3-PbTiO3 Ceramics for Enhanced Properties

    Science.gov (United States)

    Sehirlioglu, Alp; Sayir, Ali; Dynys, Fred

    2008-01-01

    High-temperature piezoelectrics are a key technology for aeronautics and aerospace applications such as fuel modulation to increase the engine efficiency and decrease emissions. The principal challenge for the insertion of piezoelectric materials is the limitation on upper use temperature which is due to low Curie-Temperature (T(sub c) and increasing electrical conductivity. BiScO3 -PbTiO3 (BS-PT) system is a promising candidate for improving the operating temperature for piezoelectric actuators due to its high TC (>400 C). Effects of Zr and Mn doping of the BS-PT ceramics have been studied and all electrical and electromechanical properties for Sc-deficient and Ti-deficient BS- PT ceramics are reported as a function of electrical field and temperature. Donor doping with Zr and Mn (in Sc deficient compositions) increased the DC-resistivity and decreased tan at all temperatures. Resulting ceramics exhibited saturated hysteresis loops with low losses and showed no dependence on the applied field (above twice the coercive field) and measurement frequency.

  18. Mechanical, electronic, optical, thermodynamic properties and superconductivity of ScGa3

    Science.gov (United States)

    Parvin, F.; Hossain, M. A.; Ali, M. S.; Islam, A. K. M. A.

    2015-01-01

    The rare occurrence of type-I superconductivity in binary system ScGa3 has experimentally been shown recently. In the present paper we study the electronic, optical, thermodynamic properties and some aspects of superconductivity of this compound using first-principles calculations. The mechanical properties like elastic constants, bulk modulus, shear modulus, Pugh's ductility index, Young's modulus, Poisson's ratio, elastic anisotropy factor, Peierls stress are calculated for the first time. The material is anisotropic and brittle. Electronic band structure, density of states, Fermi surfaces and bonding nature have also been studied. The optical functions are estimated and discussed for the first time. The high reflectivity is found in the ultraviolet regions up to ~13 eV and thus ScGa3 can serve as a possible shielding material for ultraviolet radiation. Thermal effects on some macroscopic properties of ScGa3 are predicted using the quasi-harmonic Debye model and phonon approximation in the temperature and hydrostatic pressure in the ranges of 0-1000 K and 0-40 GPa, respectively. The calculated electron-phonon coupling constant λ=0.52 yields Tc=2.6 K, which is in very good agreement with the experimentally observed value. The value of the coupling constant and the Ginzburg-Landau parameter (κ=0.09) indicate that the compound is a weak-coupled type-I rare binary BCS superconductor.

  19. Direct laser fabrication of three dimensional components using SC420 stainless steel

    International Nuclear Information System (INIS)

    Highlights: ► The feasibility of direct laser fabrication of SC402 alloy was studied. ► Three-dimensional (3D) components with varying thicknesses can be built using DLF to near net-shape. ► The build size and orientation affects the mechanical properties. ► Hot isostatic pressing can be used to homogenise the mechanical properties. - Abstract: Direct Laser Fabrication (DLF) has been used in the fabrication of three-dimensional (3D) near net-shape metallic parts using stainless steel SC420 powder. The mechanical properties and microstructure of the as-deposited SC420 and of hot isostatically pressed DLF builds were investigated as a function of deposition direction and sample size using tensile testing, scanning electron microscopy and X-ray diffraction. The influence of the build geometry and orientation on the microstructure and the mechanical properties was also assessed. From this work, it was evident that the DLF process can produce three dimensional parts with good mechanical properties (yield strength > 1000 MPa, tensile strength > 1400 MPa, elongation > 5%), which approach the properties of wrought products

  20. Effects of substituting ytterbium for scandium on the microstructure and age-hardening behaviour of Al–Sc alloy

    Energy Technology Data Exchange (ETDEWEB)

    Tuan, N.Q., E-mail: quoctuan1884@gmail.com [CT2M – Centre for Mechanical and Materials Technologies, University of Minho, Azurém, 4800-058 Guimarães (Portugal); Pinto, A.M.P.; Puga, H. [CT2M – Centre for Mechanical and Materials Technologies, University of Minho, Azurém, 4800-058 Guimarães (Portugal); Rocha, L.A. [CT2M – Centre for Mechanical and Materials Technologies, University of Minho, Azurém, 4800-058 Guimarães (Portugal); Universidade Estadual Paulista (Unesp), Faculdade de Ciências de Bauru, SP 17033-360 (Brazil); Barbosa, J. [CT2M – Centre for Mechanical and Materials Technologies, University of Minho, Azurém, 4800-058 Guimarães (Portugal)

    2014-04-01

    In order to reduce the cost of Al–Sc alloys and maintain their mechanical properties, the microstructure and mechanical properties of Al–0.24 wt% Sc–0.07 wt% Yb in comparison with Al–0.28 wt% Sc alloys were studied. The aging behaviour, precipitate morphologies, precipitate coarsening and precipitation hardening of both alloys were investigated. The average diameter and the size distribution of nanoscale Al{sub 3}Sc and Al{sub 3}(Sc,Yb) precipitates at various aging conditions were measured. Transmission electron microscopy (TEM) and high-resolution TEM were used to deeply understand the precipitate evolution. A maximum hardness around 73 (HV{sub 30}) was obtained with a precipitate diameter from 4.3 to 5.6 nm for both alloys.

  1. Effect of Sc and Zr on the in-plane anisotropy of Al-Mg-Mn alloy sheets

    Institute of Scientific and Technical Information of China (English)

    PENG Yongyi; YIN Zhimin; YANG Jin; DU Yuxuan

    2005-01-01

    The Al-Mg-Mn alloy sheets with and without trace Sc and Zr were investigated by means of tensile test, X-ray diffraction, optical microscope, and transmission electron microscope. The indexes of in-plane anisotropy (IIPA) of their tensile mechanical properties were calculated and their inverse pole figures were obtained by Harris method. The two alloy sheets have the same law of in-plane anisotropy and remarkable in-plane anisotropy of mechanical properties, and the IIPA of the alloy sheet with Sc and Zr is bigger than that of the alloy sheet without Sc and Zr. The relationships of the in-plane anisotropy and the anisotropy of the crystallographic texture were analyzed based on the model of monocrystal. It is the common action of the anisotropy of crystallography and microstructures that causes the in-plane anisotropy of their mechanical sotropy of the alloy sheet containing trace Sc and Zr.

  2. Near-barrier neutron transfer in reactions 3,6He + 45Sc and 3,6He + 197Au

    Science.gov (United States)

    Samarin, V. V.; Naumenko, M. A.; Penionzhkevich, Yu E.; Skobelev, N. K.; Kroha, V.; Mrazek, J.

    2016-06-01

    Experimental cross sections for formation of 196,198Au isotopes in reactions 3,6He + 197Au and cross sections for formation of 44,46Sc isotopes in reactions 3,6He + 45Sc have been analyzed. To calculate neutron transfer probabilities and cross sections the time- dependent Schrödinger equation for external neutrons of 3He, 6He, 45Sc and 197Au nuclei has been solved numerically. It is shown that the contribution of fusion and subsequent evaporation is significant in the case of reactions 3,6He + 45Sc, whereas in the case of reactions 3,6He + 197Au, it is negligible. Fusion-evaporation was taken into account using NRV evaporation code. Results of calculations demonstrate overall satisfactory agreement with experimental data.

  3. A 21-cm line study of NGC 5963, an SC galaxy with a low-surface brightness disk

    Science.gov (United States)

    Bosma, A.; Athanassoula, E.; van der Hulst, J. M.

    1988-06-01

    Results are presented from a detailed 21-cm line study of the Sc galaxy NGC 5963. The extent of the H I emission is found to be roughly coincident with the optical image, the latter being of much lower surface brightness than normal for Sc galaxies. The velocity field shows little deviation from axial symmetry, and the derived rotation curve is typical for Sc galaxies about twice as bright as NGC 5963. A composite mass model is presented using the observed light distribution to calculate a rotation curve for the luminous part of the galaxy (assuming a constant M/L-ratio with radius); this calculated rotation curve is compared to the observed one to derive a rotation law for a dark halo. Comparison with Sc galaxies having normal disk surface brightnesses suggests that the halo in NGC 5963 is more concentrated than in normal Scs with similar rotation curves. The origin of the low surface brightness of the disk is discussed.

  4. Hyperfine fields and magnetic momente in Laves intermetallic compounds AFe2(A=Zr, Y, Sc and Gd)

    International Nuclear Information System (INIS)

    Hyperfine fields (HFF) on impurity nuclei 27Al and 45Sc in the Laves cubic compounds ZrFe2, YFe2, ScFe2 and GdFe2 are measured by the method of pulsed nuclear magnetic resonance at 4.2 K. Using the data on 57Fe ad 27Al HFF the contributions to 57Fe HFF from local magnetic momentum of iron atoms μ0(Fe) are singled out, the values μ0(Fe) amd μ(A) are estimated. It is shown that HFF on 45Sc nuclei contain both contributions from local magnetic momentum of scandium atoms and from magnetic momenta of atoms in the nearest spheres. The contributions are evaluated for ZrFe2 and ScFe2

  5. Over-Expression of ScMnSOD, a SOD Gene Derived from Jojoba, Improve Drought Tolerance in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-fei; ZHANG Gen-fa; SUN Wei-min; LI Ze-qin; BAI Rui-xue; LI Jing-xiao; SHI Zi-han; GENG Hong-wei; ZHENG Ying; ZHANG Jun

    2013-01-01

    Jojoba (Simmondsia chinensis) is mainly distributed in desert, and the molecular mechanisms of jojoba in response to abiotic stress still remain elusive. In this paper, we cloned and characterized a SOD gene from jojoba named as ScMnSOD, and introduced into Arabidopsis to investigate its functions of responding to drought stress. The transgenic Arabidopsis showed an improvement in drought tolerance. Moreover, under a water deifcit condition, the accumulation of reactive oxygen species (ROS) was remarkably decreased in the transgenic lines compared to the WT. Furthermore, the ScMnSOD promoter was cloned to the 5´-upstream of GUS coding region in a binary vector, and introduced into Arabidopsis. And results showed that ScMnSOD expression can be induced by drought, salt, ABA, and low temperature. In conclusion, ScMnSOD plays an important role in drought tolerance which is, at least partially, attributed to its role in ROS detoxiifcation.

  6. Comparison of renal allograft (AG) biopsy diagnosis and temporal quantitation of Tc-99m sulfur colloid (SC) in clinically suspected AG rejection

    Energy Technology Data Exchange (ETDEWEB)

    George, E.A.; Brown, W.N.; Carney, K.; Naidu, R.G.; Palmer, D.C.

    1984-01-01

    The purpose of this study was to evaluate the diagnostic efficacy of temporal quantitation of SC compared to tissue diagnosis of AG needle biopsy (Bx). The principal clinical criteria for patient selection were sequential or persistent reduction (at least 40-50%) of AG function as determined by serial serum creatinine levels. Thirty-four AG recipients were examined with SC and subsequent AG Bx in 37 instances. %SC AG accumulation and bone marrow extraction were interpreted in view of the significant sequential of persistent reduction of Ag function. Each AG Bx was collected from multiple needle aspirates and processed for light microscopy and immunoflorescent staining. Bx and SC exam were evaluated for acute rejection (AR), chronic rejection (CR) or other, non-rejection pathology. Acute tissue changes superimposed on chronic were regarded as AR. Acute tissue changes and % SC AG accumulation in the rejection range were graded as mild, moderate and marked. In AR there was 28/28 agreement of Bx and SC diagnosis; of which 7/28 were superimposed on CR. In Cr Bx and SC agreed in 3/7 instances, in 3/7 SC Dx was AR and in 1/7 SC exam was normal. Sensitivity and specificity of the SC diagnosis in this series was 100% and 63% for AR, 43% and 100% for CR and 97% and 100% in all instances of rejection. Bx and SC grading of AR agreed in 64%. In conclusion, temporal quantitation of SC demonstrated overall good correlation with AG Bx diagnosis in this series. The poor sensitivity of 43% of SC in Cr and only 64% correlation in grading AR may be due to inherent Bx sampling and SC data analysis error.

  7. Effects of Sc and Y substitution on the structure and thermoelectric properties of Yb14MnSb11

    Science.gov (United States)

    Grebenkemper, Jason H.; Klemenz, Sebastian; Albert, Barbara; Bux, Sabah K.; Kauzlarich, Susan M.

    2016-10-01

    Yb14MnSb11 is the most efficient bulk p-type thermoelectric material for high temperature applications. Materials with Y and Sc substitutions in Yb14MnSb11 were made both in Sn-flux and by ball milling. These small 3+ rare earth (RE) cations were introduced with the goal of providing chemical pressure on the structure. The RE3+ cation is smaller than Yb2+ and also donates one additional electron to this p-type semiconductor. In Yb14-xRExMnSb11 (RE = Sc, Y) the maximum x was about 0.5. X-ray diffraction experiments on the single crystals obtained from Sn-flux showed that Sc preferentially substitutes for Yb(1) and Yb(3), and decreases the size of the unit cell by about 0.3%. Y substitutes on all Yb sites and increases the size of the unit cell by about 0.2%. Samples with Yb14-xRExMnSb11 (x~0.3) were prepared via powder metallurgy and spark plasma sintering for transport and thermal conductivity measurements. Electron microprobe of the Sc-substituted sample showed small regions (≤1 μ m) containing greater amounts of Sc, and X-ray powder diffraction of the ball milled Sc sample could be fitted as phase pure Yb14-xScxMnSb11. Y-substituted samples showed larger regions of excess Y in electron microprobe, and small amounts of Yb4Sb3 in X-ray powder diffraction. The Sc sample has slightly reduced carrier concentration over optimized Yb14MnSb11, while the Y samples have even lower carrier concentrations. These carrier concentrations lead to comparable resistivity to Yb14MnSb11 in the Sc-substituted material, and higher resistivities in the Y-substituted material. All materials had similar Seebeck coefficients that slightly exceed Yb14MnSb11 at high temperatures, with the Sc-substituted sample having the highest despite having a higher carrier concentration. Sc-substituted samples also had a slightly higher thermal conductivity over the Y-substituted samples, which had comparable thermal conductivity to Yb14MnSb11. The zT values of the Sc and Y substituted samples are

  8. Bullying prevention in schools by targeting cognitions, emotions, and behavior: Evaluating the effectiveness of the REBE-ViSC program.

    Science.gov (United States)

    Trip, Simona; Bora, Carmen; Sipos-Gug, Sebastian; Tocai, Ioana; Gradinger, Petra; Yanagida, Takuya; Strohmeier, Dagmar

    2015-10-01

    The effectiveness of a class-based antibullying prevention program on cognitions, emotions, and behaviors was investigated. The program consists of a cognitive-behavioral (Rational Emotive Behavioral Education; REBE) and a behavioral (Viennese Social Competence; ViSC) component. The REBE program is based on rational emotive behavioral theory and contains 9 student lessons. The ViSC program is based on social learning theory and comprises 10 student lessons. The order of the programs was experimentally manipulated. The REBE-ViSC program was implemented in 5 schools (14 classes), the ViSC-REBE program was implemented in 3 schools (9 classes), and 3 schools (11 classes) served as an untreated control group. Data were collected during 1 school year at pretest, midpoint, and posttest. Emotions (overt and internalizing anger), cognitions (learning and entitlement), and behaviors (bullying perpetration and bullying victimization) were measured with self-assessments. To examine the effectiveness of the REBE-ViSC/ViSC-REBE program, multilevel growth models were applied (time points at Level 1, individuals at Level 2, and classes at Level 3). The analyses revealed that the program effects differed depending on the order of the programs. The REBE-ViSC condition was more effective in changing negative emotions than the ViSC-REBE condition; both experimental conditions were effective in reducing dysfunctional cognitions, whereas no behavioral change was found in the 2 experimental groups when compared with the control group. To improve program effectiveness regarding behavioral changes, a multilevel whole-school approach including a teacher component is recommended.

  9. Moments Of Microdiversity EGC Receivers And Macrodiversity SC Receiver Output Signal Over Gamma Shadowed Nakagami-m Multipath Fading Channel

    Science.gov (United States)

    Djordjević, Nebojša; Jaksić, Branimir S.; Matović, Ana; Matović, Marija; Smilić, Marko

    2015-11-01

    A system with macrodiversity selection combining (SC) receiver and for microdiversity equal gain combining (EGC) receivers is considered. Received signal is subjected, simultaneously to multipath fading and shadowing, resulting in signal envelope and signal power variation. Closed form expressions for moments of macrodiversity SC receiver output signal envelope are calculated. Numerical expressions are plotted to present the influences of Gamma shadowing severity and Nakagami-m severity on moments of proposed system output signal.

  10. K2SC: flexible systematics correction and detrending of K2 light curves using Gaussian process regression

    Science.gov (United States)

    Aigrain, S.; Parviainen, H.; Pope, B. J. S.

    2016-07-01

    We present K2SC (K2 Systematics Correction), a PYTHON pipeline to model instrumental systematics and astrophysical variability in light curves from the K2 mission. K2SC uses Gaussian Process regression to model position-dependent systematics and time-dependent variability simultaneously, enabling the user to remove both (e.g. for transit searches) or to remove systematics while preserving variability (for variability studies). For periodic variables, K2SC automatically computes estimates of the period, amplitude and evolution time-scale of the variability. We apply K2SC to publicly available K2 data from Campaigns 3-5 showing that we obtain photometric precision approaching that of the original Kepler mission. We compare our results to other publicly available K2 pipelines, showing that we obtain similar or better results, on average. We use transit injection and recovery tests to evaluate the impact of K2SC on planetary transit searches in K2 Pre-search Data Conditioning data, for planet-to-star radius ratios down to Rp/R* = 0.01 and periods up to P = 40 d, and show that K2SC significantly improves the ability to distinguish between true and false detections, particularly for small planets. K2SC can be run automatically on many light curves, or manually tailored for specific objects such as pulsating stars or large amplitude eclipsing binaries. It can be run on ASCII and FITS light-curve files, regardless of their origin. Both the code and the processed light curves are publicly available, and we provide instructions for downloading and using them. The methodology used by K2SC will be applicable to future transit search missions such as TESS and PLATO.

  11. The denitrification characteristics of Pseudomonas stutzeri SC221-M and its application to water quality control in grass carp aquaculture.

    Directory of Open Access Journals (Sweden)

    Bin Deng

    Full Text Available To reduce ammonium and nitrite in aquaculture water, an isolate of the denitrifying bacterium Pseudomonas stutzeri, SC221-M, was obtained. The effects of various nitrogen and carbon sources, the ratio of carbon to nitrogen and temperature on bacterial growth, denitrification rates and the expression levels of nirS and nosZ in SC221-M were studied. The following conditions were determined to be optimal for growth and denitrification in SC221-M: NaNO2 as the nitrogen source, sodium citrate as the carbon source, a carbon to nitrogen ratio range of 4-8, and a temperature range of 20-35°C. Subsequently, SC221-M and the Bacillus cereus BSC24 strain were selected to generate microbial preparations. The results showed that addition of the microbial preparations decreased various hydrochemical parameters, including total dissolved solids, ammonium, nitrite, total nitrogen and the chemical oxygen demand. Nitrogen removal rates were highest on day 9; the removal rates of BSC24, SC221-M, a mixed preparation and a 3× mixed preparation were 24.5%, 26.6%, 53.9% and 53.4%, respectively. The mixed preparation (SC221-M+BSC24 was more effective at removing nitrogen than either the SC221-M or BSC24 preparation. Roche 454 pyrosequencing and subsequent analysis indicated that the control and other groups formed separate clusters, and the microbial community structure in the water changed significantly after the addition of microbial preparations. These results indicate that the addition of microbial preparations can improve both the water quality and microbial community structure in an experimental aquaculture system. P. stutzeri strain SC221-M and its related microbial preparations are potential candidates for the regulation of water quality in commercial aquaculture systems.

  12. Bullying prevention in schools by targeting cognitions, emotions, and behavior: Evaluating the effectiveness of the REBE-ViSC program.

    Science.gov (United States)

    Trip, Simona; Bora, Carmen; Sipos-Gug, Sebastian; Tocai, Ioana; Gradinger, Petra; Yanagida, Takuya; Strohmeier, Dagmar

    2015-10-01

    The effectiveness of a class-based antibullying prevention program on cognitions, emotions, and behaviors was investigated. The program consists of a cognitive-behavioral (Rational Emotive Behavioral Education; REBE) and a behavioral (Viennese Social Competence; ViSC) component. The REBE program is based on rational emotive behavioral theory and contains 9 student lessons. The ViSC program is based on social learning theory and comprises 10 student lessons. The order of the programs was experimentally manipulated. The REBE-ViSC program was implemented in 5 schools (14 classes), the ViSC-REBE program was implemented in 3 schools (9 classes), and 3 schools (11 classes) served as an untreated control group. Data were collected during 1 school year at pretest, midpoint, and posttest. Emotions (overt and internalizing anger), cognitions (learning and entitlement), and behaviors (bullying perpetration and bullying victimization) were measured with self-assessments. To examine the effectiveness of the REBE-ViSC/ViSC-REBE program, multilevel growth models were applied (time points at Level 1, individuals at Level 2, and classes at Level 3). The analyses revealed that the program effects differed depending on the order of the programs. The REBE-ViSC condition was more effective in changing negative emotions than the ViSC-REBE condition; both experimental conditions were effective in reducing dysfunctional cognitions, whereas no behavioral change was found in the 2 experimental groups when compared with the control group. To improve program effectiveness regarding behavioral changes, a multilevel whole-school approach including a teacher component is recommended. PMID:26376177

  13. Mechanical Properties and Strengthening Mechanisms of Al-15 Pct B4C Composites with Sc and Zr at Elevated Temperatures

    Science.gov (United States)

    Qin, Jian; Zhang, Zhan; Chen, X.-Grant

    2016-09-01

    The mechanical properties at ambient and elevated temperatures of two Al-15 vol pct B4C composites, S40 with 0.4 wt pct Sc and SZ40 with 0.4 wt pct Sc and 0.24 wt pct Zr, are investigated during long-term thermal annealing. The presence of large B4C particles in the microscale has a moderate but stable strengthening effect on Al-B4C composites at ambient and elevated temperatures, while the precipitation of nanoscale Al3Sc and Al3(Sc, Zr) in the composite matrix provides a predominate contribution to the composite strength, which is varied by tested temperatures. The Al3Sc precipitates in S40 remain coarsening resistant at 523 K (250 °C), whereas the Al3(Sc, Zr) precipitates in SZ40 are thermally stable at 573 K (300 °C) over 2000 hours of annealing. At higher annealing temperatures (573 K (300 °C) for S40 and 623 K (350 °C) for SZ40), both Al3Sc and Al3(Sc, Zr) precipitates become coarsening with prolonged annealing time. The yield strength of S40 and SZ40 at ambient temperature decreases with the increasing precipitate size, which can be explained by the classical precipitate shearing and Orowan bypass mechanisms. At elevated temperatures [523 K to 623 K (250 °C to 350 °C)], considerably lower yield stresses are observed compared to those at ambient temperature, which invokes a dislocation climb mechanism. The predicted yield strengths at elevated temperatures by the combination of dislocation climb and Orowan models are in good agreement with the experimental data.

  14. Thermoelastic properties of ScB2, TiB2, YB4 and HoB4

    DEFF Research Database (Denmark)

    Waskowska, A.; Gerward, L.; Staun Olsen, J.;

    2011-01-01

    High-pressure X-ray diffraction in ScB2, TiB2, YB4 and HoB4 powders and single crystals has been studied using synchrotron radiation as well as conventional X-rays. The experimental results are supported by calculations using density functional theory. ScB2, YB4 and HoB4 are hard materials (bulk ...

  15. Microstructure and Strengthening Mechanisms in an Ultrafine Grained Al-Mg-Sc Alloy Produced by Powder Metallurgy

    Energy Technology Data Exchange (ETDEWEB)

    Tammy J. Harrell; Troy D. Topping; Haiming Wen; Tao Hu; JULIE M. SCHOENUNG; ENRIQUE J. LAVERNIA

    2014-12-01

    Additions of Sc to an Al-Mg matrix were investigated, paying particular attention to the influence of Al3Sc precipitates and other dispersoids, as well as grain size, on mechanical behavior. Prior studies have shown that Sc significantly increases the strength of coarse-grained Al-Mg alloys. Prompted by these findings, we hypothesized that it would be of fundamental and technological interest to study the behavior of Sc additions to an ultrafine-grained (UFG) microstructure (e.g., 100’s nm). Accordingly, we investigated the microstructural evolution and mechanical behavior of a cryomilled ultrafine grained Al-5Mg-0.4Sc (wt pct) and compared the results to those of an equivalent fine-grained material (FG) produced by powder metallurgy. Experimental materials were consolidated by hot isostatic pressing (HIP’ing) followed by extrusion or dual mode dynamic forging. Under identical processing conditions, UFG materials generate large Al3Sc precipitates with an average diameter of 154 nm and spaced approximately 1 to 3 µm apart, while precipitates in the FG materials have a diameter of 24 nm and are spaced 50 to 200 nm apart. The strengthening mechanisms are calculated for all materials and it is determined that the greatest strengthening contributions for the UFG and FG materials are Mg-O/N dispersion strengthening and precipitate strengthening, respectively.

  16. Interpretation of unexpected behavior of infrared absorption spectra of ScF3 beyond the quasiharmonic approximation

    Science.gov (United States)

    Piskunov, Sergei; Žguns, Pjotrs A.; Bocharov, Dmitry; Kuzmin, Alexei; Purans, Juris; Kalinko, Aleksandr; Evarestov, Robert A.; Ali, Shehab E.; Rocca, Francesco

    2016-06-01

    Scandium fluoride (ScF3), having cubic ReO3-type structure, has attracted much scientific attention due to its rather strong negative thermal expansion (NTE) in the broad temperature range from 10 to 1100 K. Here we use the results of diffraction and extended x-ray absorption fine-structure (EXAFS) spectroscopy to interpret the influence of NTE on the temperature dependence of infrared absorption spectra of ScF3. Original infrared absorption and EXAFS experiments in a large temperature range are presented and interpreted using ab initio lattice dynamics simulations within and beyond quasiharmonic approximations. We demonstrate that ab initio electronic structure calculations, based on the linear combination of atomic orbitals method with hybrid functionals, are able to reproduce well the experimental values of lattice parameter a0, band gap Eg, and lattice dynamics in ScF3. However, the simulations performed within quasiharmonic approximation fail to reproduce the temperature dependence of two infrared active bands due to the F-Sc-F bending (at 220 cm-1) and Sc-F stretching (at 520 cm-1) modes present in the infrared absorption spectra. To overcome this problem, an approach beyond the quasiharmonic approximation is proposed: It accounts for the negative thermal expansion of the lattice and for fluorine atom displacements due to strong F vibrational motion perpendicular to the cubic axes and allows us to explain qualitatively the temperature behavior of infrared spectra of ScF3.

  17. Imaging quality of (44)Sc in comparison with five other PET radionuclides using Derenzo phantoms and preclinical PET.

    Science.gov (United States)

    Bunka, Maruta; Müller, Cristina; Vermeulen, Christiaan; Haller, Stephanie; Türler, Andreas; Schibli, Roger; van der Meulen, Nicholas P

    2016-04-01

    PET is the favored nuclear imaging technique because of the high sensitivity and resolution it provides, as well as the possibility for quantification of accumulated radioactivity. (44)Sc (T1/2=3.97h, Eβ(+)=632keV) was recently proposed as a potentially interesting radionuclide for PET. The aim of this study was to investigate the image quality, which can be obtained with (44)Sc, and compare it with five other, frequently employed PET nuclides using Derenzo phantoms and a small-animal PET scanner. The radionuclides were produced at the medical cyclotron at CRS, ETH Zurich ((11)C, (18)F), at the Injector II research cyclotron at CRS, PSI ((64)Cu, (89)Zr, (44)Sc), as well as via a generator system ((68)Ga). Derenzo phantoms, containing solutions of each of these radionuclides, were scanned using a GE Healthcare eXplore VISTA small-animal PET scanner. The image resolution was determined for each nuclide by analysis of the intensity signal using the reconstructed PET data of a hole diameter of 1.3mm. The image quality of (44)Sc was compared to five frequently-used PET radionuclides. In agreement with the positron range, an increasing relative resolution was determined in the sequence of (68)Ga<(44)Sc<(89)Zr<(11)C<(64)Cu<(18)F. The performance of (44)Sc was in agreement with the theoretical expectations based on the energy of the emitted positrons. PMID:26774390

  18. Lanthanide-doped Na xScF 3+ x nanocrystals: Crystal structure evolution and multicolor tuning

    KAUST Repository

    Teng, Xue

    2012-05-23

    Rare-earth-based nanomaterials have recently drawn considerable attention because of their unique energy upconversion (UC) capabilities. However, studies of Sc 3+-based nanomaterials are still absent. Herein we report the synthesis and fine control of Na xScF 3+x nanocrystals by tuning of the ratio of oleic acid (OA, polar surfactant) to 1-octadecene (OD, nonpolar solvent). When the OA:OD ratio was increased from low (3:17) to high (3:7), the nanocrystals changed from pure monoclinic phase (Na 3ScF 6) to pure hexagonal phase (NaScF 4) via a transition stage at an intermediate OA:OD ratio (3:9) where a mixture of nanocrystals in monoclinic and hexagonal phases was obtained and the coexistence of the two phases inside individual nanocrystals was also observed. More significantly, because of the small radius of Sc 3+, Na xScF 3+x:Yb/Er nanocrystals show different UC emission from that of NaYF 4:Yb/Er nanocrystals, which broadens the applications of rare-earth-based nanomaterials ranging from optical communications to disease diagnosis. © 2012 American Chemical Society.

  19. Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation.

    Directory of Open Access Journals (Sweden)

    Benjamin J Tillotson

    Full Text Available The equilibrium binding affinity of receptor-ligand or antibody-antigen pairs may be modulated by protonation of histidine side-chains, and such pH-dependent mechanisms play important roles in biological systems, affecting molecular uptake and trafficking. Here, we aimed to manipulate cellular transport of single-chain antibodies (scFvs against the transferrin receptor (TfR by engineering pH-dependent antigen binding. An anti-TfR scFv was subjected to histidine saturation mutagenesis of a single CDR. By employing yeast surface display with a pH-dependent screening pressure, scFvs having markedly increased dissociation from TfR at pH 5.5 were identified. The pH-sensitivity generally resulted from a central cluster of histidine residues in CDRH1. When soluble, pH-sensitive, scFv clone M16 was dosed onto live cells, the internalized fraction was 2.6-fold greater than scFvs that lacked pH-sensitive binding and the increase was dependent on endosomal acidification. Differences in the intracellular distribution of M16 were also observed consistent with an intracellular decoupling of the scFv M16-TfR complex. Engineered pH-sensitive TfR binding could prove important for increasing the effectiveness of TfR-targeted antibodies seeking to exploit endocytosis or transcytosis for drug delivery purposes.

  20. Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation.

    Science.gov (United States)

    Tillotson, Benjamin J; Goulatis, Loukas I; Parenti, Isabelle; Duxbury, Elizabeth; Shusta, Eric V

    2015-01-01

    The equilibrium binding affinity of receptor-ligand or antibody-antigen pairs may be modulated by protonation of histidine side-chains, and such pH-dependent mechanisms play important roles in biological systems, affecting molecular uptake and trafficking. Here, we aimed to manipulate cellular transport of single-chain antibodies (scFvs) against the transferrin receptor (TfR) by engineering pH-dependent antigen binding. An anti-TfR scFv was subjected to histidine saturation mutagenesis of a single CDR. By employing yeast surface display with a pH-dependent screening pressure, scFvs having markedly increased dissociation from TfR at pH 5.5 were identified. The pH-sensitivity generally resulted from a central cluster of histidine residues in CDRH1. When soluble, pH-sensitive, scFv clone M16 was dosed onto live cells, the internalized fraction was 2.6-fold greater than scFvs that lacked pH-sensitive binding and the increase was dependent on endosomal acidification. Differences in the intracellular distribution of M16 were also observed consistent with an intracellular decoupling of the scFv M16-TfR complex. Engineered pH-sensitive TfR binding could prove important for increasing the effectiveness of TfR-targeted antibodies seeking to exploit endocytosis or transcytosis for drug delivery purposes. PMID:26713870

  1. Effects of minor Sc on the microstructure and mechanical properties of Al-Zn-Mg-Cu-Zr based alloys

    Institute of Scientific and Technical Information of China (English)

    LI Wenbin; PAN Qinglin; Zou Liang; LIANG Wenjie; HE Yunbin; LIU Junsheng

    2009-01-01

    Five kinds of Al-Zn-Mg-Cu-Zr based alloys with different Sc additions were prepared by ingot metallurgy. The effects of minor Sc on the microstructure and mechanical properties of Al-Zn-Mg-Cu-Zr based alloys were investigated using tensile tests, optical microscopy (OM), and transmission electron microscopy (TEM). The results show that the ultimate tensile strength and yield strength are improved by 94 and 110 Mpa, respectively, and the elongation to failure remains at a reasonable extent (11.1%) in the Al-Zn-Mg-Cu-Zr based alloy with 0.21 wt.% Sc addition after solution heat treatment at 475℃ for 40 min and then aged at 120℃ for 24 h. The addition of minor Sc induces the formation of Al3(Sc,Zr) particles, which are highly effective in refining the cast microstructures, retarding recrystallization, and pinning dislocations. The increment of strength is attributed mainly to fine grain strengthening, precipitation strengthening of Al3(Sc,Zr) particles, and substructure strengthening.

  2. Separation of cyclotron-produced 44Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin

    Science.gov (United States)

    Valdovinos, H.F.; Hernandez, R.; Barnhart, T.E.; Graves, S.; Cai, W.; Nickles, R.J.

    2014-01-01

    Significant interest in 44Sc as a radioactive synthon to label small molecules for positron emission tomography (PET) imaging has been recently observed. Despite the efforts of several research groups, the ideal 44Sc production and separation method remains elusive. Herein, we propose a novel separation method to obtain 44Sc from the proton irradiation of calcium targets based on extraction chromatography, which promises to greatly simplify current production methodologies. Using the commercially available Uranium and Tetravalent Actinides (UTEVA) extraction resin we were able to rapidly ( 80% of the activity generated at end of bombardment (EoB) in small ~1 M HCl fractions (400 μL). The chemical purity of the 44Sc eluates was evaluated through chelation with DOTA and DTPA, and by trace metal analysis using microwave induced plasma atomic emission spectrometry. The distribution coefficients (Kd) of Sc(III) and Ca(II) in UTEVA were determined in HCl medium in a range of concentrations from zero to 12.1 M The 44Sc obtained with our method proved to be suitable for the direct labeling of small biomolecules for PET imaging, with excellent specific activities and radiochemical purity. PMID:25464172

  3. SC125大型CNC数控车床控制系统的改造%Rebuild of control system of large module SC125 CNC vertical lathe

    Institute of Scientific and Technical Information of China (English)

    卢绍良; 刘福才

    2004-01-01

    针对罗马尼亚SC125大型数控立车主轴定位分度系统问题,提出了用西门子CNC控制交流伺服进给系统进行改造的方案,并进行了有关硬件和软件设计,完成了主轴分度定位控制的高性能数控机床的改造,使该立车具有七种工作模式,实现车削与铣削为一体的两种控制方式.通过误差补偿达到了较高定位精度.完成了电气驱动系统的改造.

  4. Single crystal CrN/ScN superlattice soft X-ray mirrors: Epitaxial growth, structure, and properties

    Energy Technology Data Exchange (ETDEWEB)

    Birch, J. [Department of Physics, IFM, Linkoeping University, SE-581 83 Linkoeping (Sweden); Joelsson, T. [Department of Physics, IFM, Linkoeping University, SE-581 83 Linkoeping (Sweden); Eriksson, F. [Department of Physics, IFM, Linkoeping University, SE-581 83 Linkoeping (Sweden)]. E-mail: freer@ifm.liu.se; Ghafoor, N. [Department of Physics, IFM, Linkoeping University, SE-581 83 Linkoeping (Sweden); Hultman, L. [Department of Physics, IFM, Linkoeping University, SE-581 83 Linkoeping (Sweden)

    2006-08-30

    Single crystal CrN/ScN superlattice films with modulation periods of 1.64 nm were grown on MgO(001) substrates. By utilizing a magnetically enhanced plasma in the vicinity of the substrate and a negative substrate bias, ion/metal nitride flux ratios of 45 and 144 were achieved during deposition of CrN and ScN, respectively. The effects of ion energies in the range [16-58 eV] and substrate temperatures in the range [535-853 deg. C] on the composition, interface width, crystal quality, and microstructure evolution were investigated using elastic recoil detection analysis, hard X-ray reflectivity, X-ray diffraction, and transmission electron microscopy (TEM). Minimal interface widths of 0.2 nm = 1/2 nitride unit cell were achieved at a growth temperature of 735 deg. C and ion energies of 24 and 28 eV for CrN and ScN, respectively. Under these conditions, also an optimum in the crystal quality was observed for near stoichiometric composition of CrN and ScN. TEM confirmed a cube-on-cube epitaxial relationship for the system with CrN(001) ScN(001) MgO(001) and CrN[100] ScN[100] MgO[100]. Also, the layers were coherently strained to each other with no misfit dislocations, threading dislocations, surface cusps, voids or gas bubbles present. Higher ion energies or lower deposition temperatures gave over-stoichiometric films with poor superlattice modulation while higher growth temperatures yielded a decreased crystal quality, due to loss of N. As-deposited superlattices with only 61 periods exhibited an absolute soft X-ray reflectance of 6.95% at an energy of 398.8 eV (Sc 2p-absorption edge) which is comparable to the performance of Cr/Sc. The compositional modulation and phase structure was stable during extended annealing at 850 deg. C, which is the highest thermal stability for an X-ray multilayer mirror. It is concluded that the ScN layers serve as effective diffusion barriers to hinder decomposition of the CrN layers and stabilize the pseudomorphic superlattice

  5. Theoretical Insight into Sc2O@C84: Interplay between Small Cluster and Large Carbon Cage.

    Science.gov (United States)

    Guo, Yi-Jun; Zhao, Xiang; Zhao, Pei; Yang, Tao

    2015-10-15

    Very recently, a series of endohedral fullerenes Sc2O@C2n (n = 35-47) were facilely produced. However, only two of them have been further characterized so far. Theoretically, we studied another discandium oxide endohedral fullerene without any characterizations, Sc2O@C84, which is the second most-abundant species in terms of relative heights of all mass spectrum peaks. Two thermodynamically stable isomers with isolated pentagon rule-obeying cages were found, namely, Sc2O@C2v(51575)-C84 and Sc2O@C1(51580)-C84. This is the first case that an endohedral fullerene containing the C2v(51575)-C84 cage acts as the lowest-energy isomer, and it is the first report of a clusterfullerene containing the C1(51580)-C84 cage. The endohedral Sc2O cluster can keep its ideal structure after encapsulation, while both C84 cages have deformed dramatically. Orbital analysis suggests that nucleophilic and oxidization reactions of both isomers should take place on the cage, while regioselectivity of Sc2O@C2v(51575)-C84 and Sc2O@C1(51580)-C84 is different due to their different characteristics of the highest occupied orbital distribution. Two-dimensional electron localization function and Laplacian of electron density maps unambiguously indicate strong electrostatic interactions exist between one scandium atom and the oxygen one. Meanwhile, overlaps of occupied metal atom orbitals and the cage ones along with Mayer bond order analysis identify that covalent interactions between a scandium atom and each C84 cage cannot be neglected. At last, (13)C NMR, UV-vis-NIR, and IR spectra of both Sc2O@C84 isomers were simulated theoretically. Because of their structural difference, all spectra between two isomers are significantly divergent. Consequently, these spectra are helpful to distinguish Sc2O@C2v(51575)-C84 and Sc2O@C1(51580)-C84 in further experimental characterizations. PMID:26390279

  6. Humoral immune responses induced by anti-idiotypic antibody fusion protein of 6B11scFv/hGM-CSF in BALB/c mice

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Background We have previously developed and characterized a monoclonal anti-idiotype antibody, designated 6B11, which mimics an ovarian carcinoma associated antigen OC166-9 and whose corresponding monoclonal antibody is COC166-9 (Ab1). In this study, we evaluate the humoral immune responses induced by the fusion protein 6B11 single-chain variable fragment (scFv)/human granulocyte macrophage colony-stimulating factor (hGM-CSF) and 6B11scFv in BALB/c mice. Methods The fusion protein 6B11scFv/hGM-CSF was constructed by fusing a recombinant single-chain variable fragment of 6B11scFv to GM-CSF. BALB/c mice were administrated by 6B11scFv/hGM-CSF and 6B11scFv, respectively. Results The fusion protein 6B11scFv/hGM-CSF retained binding to the anti-mouse F(ab)2' and was also biologically active as measured by proliferation of human GM-CSF dependent cell TF1 in vitro. After immunization with the 6B11scFv/hGM-CSF and 6B11ScFv, BALB/c mice showed significantly enhanced Ab3 antibody responses to 6B11scFv/hGM-CSF compared with the 6B11scFv alone. The level of Ab3 was the highest after the first week and maintained for five weeks after the last immunization. Another booster was given when the Ab3 titer descended, and it would reach to the high level in a week. Conclusion The fusion protein 6B11scFv/hGM-CSF can induce humoral immunity against ovarian carcinoma in vivo. We also provide the theoretical foundation for the application of the fusion protein 6B11scFv/hGM-CSF for active immunotherapy of ovarian cancer.

  7. Effects of trace Be and Sc addition on the thermal stability of Al–7Si–0.6Mg alloys

    Energy Technology Data Exchange (ETDEWEB)

    Tzeng, Yu-Chih [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China); Wu, Chih-Ting [Department of Vehicle Engineering, Army Academy R.O.C., Jhongli, Taiwan (China); Yang, Cheng-Hsien [Institute of Materials Science and Engineering, National Central University, Jhongli, Taiwan (China); Lee, Sheng-Long, E-mail: shenglon@cc.ncu.edu.tw [Department of Mechanical Engineering, National Central University, Jhongli, Taiwan (China)

    2014-09-22

    In the present study, the effects of trace amounts of beryllium (Be, 0.05 wt%) and scandium (Sc, 0.04 wt%) addition on the microstructures and thermal stability of Al–7Si–0.6Mg alloys were investigated. The results show that traces of Be and Sc significantly reduce the amount of the iron-bearing phase and the interdendritic shrinkage. Be transformed the acicular iron-bearing phases into the nodular Al–Fe–Si iron-bearing phase, which is less harmful to ductility. Moreover, the addition of Be increased the Mg content of the solid solution within the matrix, prompting greater precipitation of the metastable Mg{sub 2}Si phase after T6 heat treatment and effectively enhancing the mechanical properties of the alloy. However, during the following thermal exposure at 250 °C for 100 h, the metastable Mg{sub 2}Si phase grew into the coarse β-Mg{sub 2}Si equilibrium phase, resulting in a decrease in the mechanical strength of the alloy. Meanwhile, the addition of Sc had insignificant effect on the amount of metastable Mg{sub 2}Si phase that precipitated. However, here, the iron-bearing phase was a nodular Al{sub 12}Si{sub 6}Fe{sub 2}(Mg,Sc){sub 5} phase, which significantly enhanced the density of the castings. After the same thermal exposure procedure, it was remarkably found that the precipitation of fine Al{sub 3}Sc particles effectively inhibited grain growth and hindered the movement of dislocations. These factors led to the Sc-containing alloy having better mechanical properties (strength and ductility) than the alloys without Sc or with Be during the following thermal exposure at 250 °C.

  8. Cloning and sequence analysis of promoter in sugarcane ethylene receptor gene (Sc-ERS)%甘蔗乙烯受体Sc-ERS启动子的克隆与序列分析

    Institute of Scientific and Technical Information of China (English)

    黄静丽; 牛俊奇; 朱惠; 杨丽涛; 李杨瑞; 王爱勤

    2013-01-01

    [目的]克隆甘蔗乙烯受体Sc-ERS基因启动子序列,分析Sc-ERS基因启动子序列的作用元件.[方法]采用基于热不对称交错式PCR原理的染色体步移技术,从甘蔗ROC22基因组DNA中克隆Sc-ERS基因启动子序列,利用启动子预测软件PlantCARE和PLACE在线工具对Sc-ERS启动子序列的作用元件进行预测.[结果]克隆获得Sc-ERS启动子序列1410 bp,该序列与玉米ERS25、ERS14核苷酸同源性分别为82%和80%.PlantCARE在线分析结果表明,该序列具有启动子基本作用元件TATA-BOX和CAAT-BOX,还含有参与光响应元件、干旱诱导MYB结合位点、茉莉酸甲酯响应元件、水杨酸响应元件、胚乳表达顺式调控元件、热胁迫响应元件等.[结论]从甘蔗基因组DNA中克隆获得乙烯受体Sc-ERS基因上游1410 bp的启动子序列,该序列含有多个特异性调控元件,推测Sc-ERS基因的表达可能受生理周期、激素、干旱、光照等因素调控.%[Objective]The present study was conducted to clone the promoter sequence of sugarcane ethylene receptor (Sc-ERS) and analyze its acting elements.[Method]Sc-ERS promoter sequence was cloned from the genomic DNA of sugarcane cultivar ROC22 with chromosome walking technology based on thermal asymmetric interlaced PCR principle,and the acting elements of Sc-ERS were analyzed with PlantCARE and PLACE online tools.[Result]The gene promoter sequence of Sc-ERS was cloned,and it was 1410 bp in size sharing 82% and 80% homology with the sequences of ERS25 and ERS14 of corn,respectively.PlantCARE online analysis results showed that the gene promoter sequence of Sc-ERS had promoter acting elements TATA-BOX and CAAT-BOX,light-responsive elements,drought-induced MYB binding sites,methyl jasmonateresponsive element,salicylic acid response element,endosperm expression cis-regulatory elements,heat stress responsive elements and so on.[Conclusion]A 1410 bp promoter sequence of Sc-ERS was cloned from sugarcane

  9. Microstructural evolution in recrystallized and unrecrystallized Al-Mg-Sc alloys during superplastic deformation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, F.C.; Xue, P. [Shenyang National Laboratory of Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China); Ma, Z.Y., E-mail: zyma@imr.ac.cn [Shenyang National Laboratory of Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer Microstructural evolution of extruded Al-Mg-Sc was divided into three stages. Black-Right-Pointing-Pointer Subgrain rotation and coalescence occurred in early strain hardening stage. Black-Right-Pointing-Pointer Dynamic recrystallization in the middle stage resulted in strain softening. Black-Right-Pointing-Pointer Grain boundary sliding and dynamic grain growth occurred in final deformation stage. Black-Right-Pointing-Pointer Friction stir processed alloy remained a random grain distribution at various strains. - Abstract: The microstructural evolution of unrecrystallized (extruded) and recrystallized (friction stir processed, FSP) Al-Mg-Sc alloys during superplastic straining was investigated using electron backscatter diffraction (EBSD). The unrecrystallized structure gradually transformed into a recrystallized structure, characterized by equiaxed grains, random boundary misorientation distribution and a weak texture at high strains. This evolution was divided into three stages based on true stress-strain curves and EBSD maps, i.e. subgrain rotation and coalescence in the early stage, dynamic recrystallization in the middle stage, and grain boundary sliding (GBS) and dynamic grain growth in the final stage. By comparison, the recrystallized grains in the FSP Al-Mg-Sc maintained a random distribution during the whole deformation process, however the grain size increased significantly with increasing strain, indicating that the main deformation mechanism was always GBS and dynamic grain growth. A deformation model was proposed to explain the microstructural evolution during superplastic deformation. The microstructure with the random boundary misorientations reaches a dynamic balance because the transformation between high-angle grain boundaries and low-angle grain boundaries is equivalent.

  10. Spark plasma sintering of a nanocrystalline Al-Cu-Mg-Fe-Ni-Sc alloy

    Science.gov (United States)

    Zúñiga, Alejandro; Ajdelsztajn, Leonardo; Lavernia, Enrique J.

    2006-04-01

    The microstructure and aging behavior of a nanocrystalline Al-Cu-Mg-Fe-Ni-Sc alloy was studied. The nanocrystalline powders were produced by milling at liquid nitrogen temperature and then consolidated using spark plasma sintering (SPS). The microstructure after SPS consisted of a bimodal aluminum grain structure (coarse-grained and fine-grained regions), along with Al9FeNi and Al2CuMg particles dispersed throughout. The microstructure observed in the as-consolidated sample is rationalized on the basis of high current densities that are generated during sintering. Solution treatment and aging of the SPS Al-Cu-Mg-Fe-Ni-Sc sample resulted in softening instead of hardening. This observation can be explained by the reduced amount of Cu, Mg, and Si in solid solution available to form S' Al2CuMg due to the precipitation of Al7FeCu2 and Si-rich particles, and by the fact that rodlike S' Al2CuMg particles could only precipitate out in the coarse-grained regions, greatly decreasing their influence on the hardness. This lack of precipitation in the fine-grained region is argued to represent a new physical observation and is rationalized on the basis of physical and thermodynamic effects. The nanocrystalline SPS Al-Cu-Mg-Fe-Ni-Sc sample was also extremely thermally stable, retaining a fine-grained structure even after solution treatment at 530°C for 5 h. The observed thermal stability is rationalized on the basis of solute drag and Zener pinning caused by the impurities introduced during the cryomilling process.

  11. Nuclear spectroscopy of 24Na and 46Sc by thermal neutron capture

    International Nuclear Information System (INIS)

    The measurement of the intensity and the energy of γ-rays produced by capture of thermal neutrons in 45Sc is reported. Of the total primary transition strength 99% could be accounted for and 426 lines could be placed in a 46Sc level scheme containing 27 previously unobserved levels. The reaction Q-value was determined as 8760.77. Of the 158 γ-rays ascribed to the 23Na(n,γ)24Na reaction, 143 have been placed in a 24Na decay scheme accounting for 100% of the total primary strength. The reaction Q-value amounts to 6959.42. The data resulted in spin assignments for four and spin restrictions for six levels. The circular polarization of 14 γ-rays from the capture of polarized neutrons has been measured. The Jsup(π) = 2+ channel spin contribution has been determined model-independently and unambiguously for 22 primary transitions. The average Jsup(π) = 2+ channel contribution is 5.8%. Spins of final levels are in agreement with previous assignments. For three levels spin restrictions have been made. The energies of positive parity levels are in agreement with a shell model calculation in the complete sd shell. Finally, the nuclear level densities of the 24Na, 46Sc, 484950Ti, 60Co, 6465Cu and 239U nuclei recently investigated by means of thermal neutron capture are described with the Fermi gas theory. Experimentally observed pairing effects in the level density parameter for nuclei in the mass region A = 40-81 are explained theoretically. (Auth.)

  12. Molecular dynamics study of ion capture from water by a model ionophore, tetraprotonated cryptand SC24

    Science.gov (United States)

    Owenson, Brian; Macelroy, Robert D.; Pohorille, Andrew

    1988-01-01

    The molecular dynamics of chloride capture from water by the tetraprotonated cryptand SC24 has been studied for the cases of 19 distances between the criptand and the chloride. The chloride capture is found to be characterized by a rapid cooperative change in the conformation of the cryptand when the Cl(-) begins to enter the ligand and just as it encounters the energy barrier. The conformational transition is associated with a shift of three N-H bonds from the pure endo orientation, such that they point toward the chloride.

  13. Electronic structure of new mixed Ti13MC13 nanocrystallites (M = Sc, V, ..., Cu)

    International Nuclear Information System (INIS)

    The electron structure of the series of new Ti13MC13 metal-carbon molecular nanocrystallites is studied through the ab initio self-consistent discrete variation method. The third order metals (Sc, V, ..., Cu) are considered as the M-elements. The regularities of forming the electron structure, chemical bonds, charge distributions and atomic magnetic moments in the Ti13MC13 in dependence on the M-atom type and its position in the source Ti14C13 nanocrystallite are forecasted. The obtained results are compared with the electron states calculations of the 3d-admixtures in the crystalline titanium carbide

  14. The NASA/IPAC/NExScI Star and Exoplanet Database

    OpenAIRE

    Berriman, G. B.; Ali, B.; Baker, R; von Braun, K.; Chiu, N-M.; Ciardi, D. R.; Good, J.; Kane, S.R.; Kong, M.; Laity, A. C.; McElroy, D. L.; Monkewitz, S.; Payne, A N; Ramirez, S.; Schmitz, M.

    2009-01-01

    The NASA/IPAC/NExScI Star and Exoplanet Database (NStED) is a general purpose stellar archive which supports NASA planet-finding and planet-characterization goals, stellar astrophysics, and the planning of NASA and other space missions. There are two principal components of NStED: a database of 140,000 nearby stars and exoplanet-hosting stars, and an archive dedicated to high precision photometric surveys for transiting exoplanets (NStED-ETSS). We present summaries of these components. The NS...

  15. Conversion of the dual training aircraft (DC into single control advanced training aircraft (SC. Part I

    Directory of Open Access Journals (Sweden)

    Ioan ŞTEFĂNESCU

    2011-03-01

    Full Text Available Converting the DC school jet aircraft into SC advanced training aircraft - and use them forthe combat training of military pilots from the operational units, has become a necessity due to thebudget cuts for Air Force, with direct implications on reducing the number of hours of flight assignedto operating personnel for preparing and training.The purpose of adopting such a program is to reduce the number of flight hours allocated annuallyfor preparing and training in advanced stages of instruction, for every pilot, by more intensive use ofthis type of aircraft, which has the advantage of lower flight hour costs as compared to a supersoniccombat plane.

  16. The crystal structure of Sc{sub 5}Co{sub 2}In{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Tyvanchuk, Yuriy; Gulay, Nataliya; Bigun, Inna; Kalychak, Yaroslav [Ivan Franko National University of Lviv (Ukraine). Analytical Chemistry Dept.; Galadzhun, Yaroslav [Ivan Franko National University of Lviv (Ukraine). Dept. of Life Safety

    2015-07-01

    The new intermetallic compound Sc{sub 5}Co{sub 2}In{sub 4} was synthesized by arc melting of the pure metals. Its crystal structure was investigated from single-crystal X-ray data: Pbam, a = 17.3400(7), b = 7.5940(5), c = 3.3128(2) Aa, R1 = 0.0337, wR2 = 0.0620 for 1502 independent reflections with [I > 2 σ(I)]. It is the first representative of the Lu{sub 5}Ni{sub 2}In{sub 4} type with cobalt.

  17. Flashlamp pumped lasing performance of Cr/sup 3+/:GdScGa-Garnet

    International Nuclear Information System (INIS)

    Chromium doped GdScGa-Garnet (Cr:GSGG) exhibits broadband fluorescence in the 700-900 nm region. Growth of this material and lasing at 790 nm with laser pumping was previously reported. Another work subsequently reported flashlamp pumped lasing of a 3.9 mm by 40 m Cr:GSGG rod. In this paper, the authors report on lasing performance of a flashlamp pumped Cr:GSGG laser rod and its lasting threshold for different operating temperatures. Evidence is presented that points to excited state absorption as a limiting factor in this material's performance

  18. Optical and Electronic Properties of Double Perovskite Ba2ScSbO6

    OpenAIRE

    Ray, Rajyavardhan; Himanshu, A. K.; Kumar, Uday; Sen, Pintu; Lahiri, J.; Bandyopadhyay, S K; Sinha, T. P.

    2015-01-01

    Ba2ScSbO6 (BSS) has been synthesized in polycrystalline form by solid state reaction. Structural characterization of the compound was done through X-ray diffraction (XRD) followed by Riedvelt analysis of the XRD pattern. The crystal structure is cubic, space group Fm-3m (No. 225. Optical band-gap of the present system has been calculated using the UV-Vis Spectroscopy to be 4.2eV. A detailed study of the electronic properties has also been carried out using the Full-Potential Linear Augmented ...

  19. ESR evidence of octahedral site occupation in ScH/sub x/:Er

    International Nuclear Information System (INIS)

    The Er3+ electron spin resonance spectrum at low temperatures in powdered Sc 9988Er 0012H191 contains a GAMMA7 doublet and associated hyperfine components with cubic site symmetry plus four additinal resonances arising from two distinct transitions with axial site symmetry. The axial lines are attributed to octahedral site occupation by protons in the vicinity of some Er3+ impurities. The two axial transitions may be associated with two different types of distortions of the GAMMA7 wave functions or possibly a GAMMA81 quartet state

  20. A humanized anti-M2 scFv shows protective in vitro activity against influenza

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M [Los Alamos National Laboratory; Velappan, Nileena [Los Alamos National Laboratory; Schmidt, Jurgen G [Los Alamos National Laboratory

    2008-01-01

    M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.

  1. In vitro deletions in the partition locus of plasmid pSC101.

    OpenAIRE

    Kalla, S R; Gustafsson, P

    1984-01-01

    Deletion mutants in the 375-base-pair EcoRI-AvaI fragment carrying the partition locus of plasmid pSC101 were formed by the combined action of exonuclease III and nuclease S1. Six deletion mutants were isolated, and the endpoints of the deletions were sequenced. One of the deletions extended 69 base pairs from the EcoRI site without impairing plasmid stability. The other five deletions caused the plasmid to be unstable and extended 199 to 251 base pairs from the EcoRI site.

  2. Unnatural-parity states in {sup 44}{sub 21}Sc{sub 23}

    Energy Technology Data Exchange (ETDEWEB)

    Lach, M.; Styczen, J.; Meczynski, W.; Grebosz, J.; Maj, A.; Zieblinski, M. [Polish Academy of Sciences, Henryk Niewodniczanski Institute of Nuclear Physics, Krakow (Poland); Bednarczyk, P. [Polish Academy of Sciences, Henryk Niewodniczanski Institute of Nuclear Physics, Krakow (Poland); Gesellschaft fuer Schwerionen, Darmstadt (Germany); Bracco, A. [Universita degli Studi di Milano and INFN, Milano (Italy); Merdinger, J.C.; Schulz, N. [Institut de Recherches Subatomiques, Strasbourg (France); Smith, M.B.; Spohr, K.M. [University of Paisley, Paisley, Scotland (United Kingdom)

    2005-07-01

    High-spin states of the {sup 44}Sc nucleus, populated in the 68 MeV {sup 18}O+{sup 30}Si reaction, have been studied in a {gamma}-{gamma}-recoil coincidence experiment. The detailed decay pattern, with various paths and cross-transitions, has been extended up to 9.1 MeV. High-quality DCO and polarization information assign spins and parities for the majority of the observed levels. The negative-parity states are discussed and compared with rotational bands in neighbouring f{sub 7/2}-shell nuclei. (orig.)

  3. Outline and schedule for the HTGR-SC/C licensing plan

    International Nuclear Information System (INIS)

    The Licensing Plan is based on licensing a HTGR-SC/C lead plant in the near term. The plan also provides reference safety material and a basis (requirements, criteria, etc.) for licensing commercial follow-on plants. The plan is structured in two parts: program management and project management, and covers three sequences of licensing activities: pre-application, construction permit application, and operating licensing application. Major activities and a schedule of events are outlined in these three phases indicating the approach, the objective and the documentation involved. The Licensing Plan will be further developed in detail in FY 1982 as part of a Project Decision Package

  4. Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction

    Science.gov (United States)

    Fehl, Charlie; Hirt, Erin E.; Li, Sze-Wan; Aubé, Jeffrey

    2015-01-01

    The intramolecular Schmidt reaction of ketones and tethered azides is an efficient method for the generation of amides and lactams. This reaction is catalyzed by Lewis acids, which tightly bind the strongly basic amide product and result in product inhibition. We report herein conditions to achieve a catalytic Schmidt reaction using substoichiometric amounts of the heat-stable Lewis acid Sc(OTf)3. This species was shown to effectively release products of the Schmidt reaction in a temperature-dependent fashion. Thus, heat was able to promote catalyst turnover. A brief substrate scope was conducted using these conditions. PMID:26085693

  5. Pesquisa de clima organizacional em empresas de desenvolvimento de software de Blumenau – SC

    OpenAIRE

    Aléssio, Simone Cristina; Dalfovo, Oscar; Dalfovo, Michael Samir; Fialho, Francisco Antonio Pereira

    2009-01-01

    O objetivo deste trabalho é estudar a influência das variáveis que compõem o Clima Organizacional em ambientes de desenvolvimento de software do município de Blumenau, SC, com o propósito de analisar as relações existentes nestes ambientes de trabalho. Parte-se do pressuposto de que as pessoas são as figuras mais importantes em uma organização, e o modo como se sente é fundamental para o equilíbrio de todos. Por isso, enfoca-se bastante a questão da cultura organizacional, que influencia dire...

  6. Pesquisa de clima organizacional em empresas de desenvolvimento de software de Blumenau – SC

    OpenAIRE

    Simone Cristina Aléssio; Oscar Dalfovo; Michael Samir Dalfovo; Francisco Antonio Pereira Fialho

    2010-01-01

    O objetivo deste trabalho é estudar a influência das variáveis que compõem o Clima Organizacional em ambientes de desenvolvimento de software do município de Blumenau, SC, com o propósito de analisar as relações existentes nestes ambientes de trabalho. Parte-se do pressuposto de que as pessoas são as figuras mais importantes em uma organização, e o modo como se sente é fundamental para o equilíbrio de to...

  7. SC-FDE for MMF short reach optical interconnects using directly modulated 850 nm VCSELs

    DEFF Research Database (Denmark)

    Teichmann, Victor S. C.; Barreto, Andre N.; Pham, Tien Thang;

    2012-01-01

    We propose the use of single-carrier frequency-domain equalization (SC-FDE) for the compensation of modal dispersion in short distance optical links using multimode fibers and 850 nm VCSELs. By post-processing of experimental data, we demonstrate, at 7.9% overhead, the error-free transmission (ov...... a 4 Mbit sequence) of OOK-modulated 5 Gbps over 2443 meters of OM3 fiber (with a nominal 3300 MHz×km bandwidth). The proposed solution may be applied as a low cost alternative for data center and supercomputer interconnects....

  8. Production of monoclonal anti-GP Ⅱ b/Ⅲa scFv antibodies from scFv phage libraries%从scFv噬菌体抗体库中筛选抗GPⅡ b/Ⅲa单链抗体

    Institute of Scientific and Technical Information of China (English)

    夏红利; 谭最; 陈德杰; 乔建国; 邱仁峰

    2011-01-01

    目的 从scFv噬菌体库中获取人源化特异性Anti-GPⅡb/Ⅲa单克隆scFv抗体.方法 对Tomlinson I+J scFv文库进行3次淘洗,富集特异性的抗GPⅡb/Ⅲa抗体.通过酶联免疫吸附试验(ELISA)和双脱氧终止法基因测序及同源性对比,检测出人源化的抗GPⅡb/Ⅲa单克隆抗体.结果 在3次淘洗后,得到了抗GPⅡb/Ⅲa单克隆噬菌体抗体,阳性克隆的获取率在95.6%以上;ELISA和基因测序筛选出25种不同的全长抗GPⅡb/Ⅲa噬菌体抗体,这些基因序列与人免疫球蛋白可变区基因同源性达到89%以上;分泌性抗体ELISA检测提示这些抗体顺利表达了蛋白并特异性结合GPⅡb/Ⅲa,其中15种scFv对GPⅡb/Ⅲa有更强的阳性反应.结论 人源化的特异性抗-GPⅡb/Ⅲa scFv能通过噬菌体展示技术快速有效地获得.%Objective To screen monoclonal anti-GP Ⅱ b/Ⅲ a antibodies from scFv phage libraries and obtain specific monoclonal anti-GP Ⅱ b/Ⅲ a scFv. Methods Specific anti-GP Ⅱ b/Ⅲ a scFv antibodies were enriched by three rounds of selection from Tomlinson Ⅰ + J libraries. By using polyclonal and monoclonal phage enzyme linked immunosorbent assay ( ELISA) and gene sequencing by bideoxy chain termination, full-length specific monoclonal anti-GP Ⅱ b/Ⅲ a antibodies were picked out and their gene sequences were obtained. Results Twenty-five different full-length monoclonal scFv phage fragments were obtained after three rounds of panning and their gene sequences were identified, and positive rate of monoclones was above 95.6%; homology comparison with variable regions of human immunoglobulin gene showed the similarity was above 89%; the result of soluble scFv ELISA showed that these specific scFv could be expressed smoothly, and 15 full-length monoclonal scFv antibodies were stronger positive than the other in these scFv. Conclusion Antibody phage display was a rapid and effective method to obtain Anti-GP Ⅱ b/Ⅲ a scFv fragements.

  9. Carbon Dioxide Activation by Scandium Atoms and Scandium Monoxide Molecules: Formation and Spectroscopic Characterization of ScCO3 and OCScCO3 in Solid Neon.

    Science.gov (United States)

    Zhang, Qingnan; Qu, Hui; Chen, Mohua; Zhou, Mingfei

    2016-01-28

    The reactions of carbon dioxide with scandium monoxide molecules and scandium atoms are investigated using matrix isolation infrared spectroscopy in solid neon. The species formed are identified by the effects of isotopic substitution on their infrared spectra as well as density functional calculations. The results show that the ground state ScO molecule reacts with carbon dioxide to form the carbonate complex ScCO3 spontaneously on annealing. The ground state Sc atom reacts with two carbon dioxide molecules to give the carbonate carbonyl complex OCScCO3 via the previously reported OScCO insertion intermediate on annealing. The observation of these spontaneous reactions is consistent with theoretical predictions that both the Sc + 2CO2 → OCScCO3 and ScO + CO2 → ScCO3 reactions are thermodynamically exothermic and are kinetically facile, requiring little or no activation energy.

  10. Zero lattice mismatch and twin-free single crystalline ScN buffer layers for GaN growth on silicon

    Energy Technology Data Exchange (ETDEWEB)

    Lupina, L.; Zoellner, M. H.; Dietrich, B.; Capellini, G. [IHP, Im Technologiepark 25, 15236 Frankfurt, Oder (Germany); Niermann, T.; Lehmann, M. [Technische Universität Berlin, Institut für Optik und Atomare Physik, Straße des 17. Juni 135, 10623 Berlin (Germany); Thapa, S. B.; Haeberlen, M.; Storck, P. [SILTRONIC AG, Hanns-Seidel-Platz 4, 81737 München (Germany); Schroeder, T. [IHP, Im Technologiepark 25, 15236 Frankfurt, Oder (Germany); BTU Cottbus, Konrad-Zuse-Str. 1, 03046 Cottbus (Germany)

    2015-11-16

    We report the growth of thin ScN layers deposited by plasma-assisted molecular beam epitaxy on Sc{sub 2}O{sub 3}/Y{sub 2}O{sub 3}/Si(111) substrates. Using x-ray diffraction, Raman spectroscopy, and transmission electron microscopy, we find that ScN films grown at 600 °C are single crystalline, twin-free with rock-salt crystal structure, and exhibit a direct optical band gap of 2.2 eV. A high degree of crystalline perfection and a very good lattice matching between ScN and GaN (misfit < 0.1%) makes the ScN/Sc{sub 2}O{sub 3}/Y{sub 2}O{sub 3} buffer system a very promising template for the growth of high quality GaN layers on silicon.

  11. Carbon Dioxide Activation by Scandium Atoms and Scandium Monoxide Molecules: Formation and Spectroscopic Characterization of ScCO3 and OCScCO3 in Solid Neon.

    Science.gov (United States)

    Zhang, Qingnan; Qu, Hui; Chen, Mohua; Zhou, Mingfei

    2016-01-28

    The reactions of carbon dioxide with scandium monoxide molecules and scandium atoms are investigated using matrix isolation infrared spectroscopy in solid neon. The species formed are identified by the effects of isotopic substitution on their infrared spectra as well as density functional calculations. The results show that the ground state ScO molecule reacts with carbon dioxide to form the carbonate complex ScCO3 spontaneously on annealing. The ground state Sc atom reacts with two carbon dioxide molecules to give the carbonate carbonyl complex OCScCO3 via the previously reported OScCO insertion intermediate on annealing. The observation of these spontaneous reactions is consistent with theoretical predictions that both the Sc + 2CO2 → OCScCO3 and ScO + CO2 → ScCO3 reactions are thermodynamically exothermic and are kinetically facile, requiring little or no activation energy. PMID:26738558

  12. A distorted tetrahedral metal oxide cluster inside an icosahedral carbon cage. Synthesis, isolation, and structural characterization of Sc4(mu3-O)2@Ih-C80.

    Science.gov (United States)

    Stevenson, Steven; Mackey, Mary A; Stuart, Melissa A; Phillips, J Paige; Easterling, Michael L; Chancellor, Christopher J; Olmstead, Marilyn M; Balch, Alan L

    2008-09-10

    The remarkably large cluster Sc4(mu3-O)2 has been obtained trapped inside an Ih-C80 cage by conducting the vaporization of graphite rods doped with copper(II) nitrate and scandium(III) oxide in an electric arc under a low pressure helium atmosphere with an added flow of air. The product has been isolated by chromatography and identified by high-resolution mass spectrometry. The structure of Sc4(mu3-O)2@Ih-C80 has been determined by X-ray crystallography on a crystal of Sc4(mu3-O)2@Ih-C80.NiII(OEP).2(C6H6). The Sc4(mu3-O)2 unit consists of a distorted tetrahedron of scandium atoms with oxygen atoms bridging two of its faces. The Sc-Sc distances range from 2.946(7) to 3.379(7) A. PMID:18702488

  13. Zero lattice mismatch and twin-free single crystalline ScN buffer layers for GaN growth on silicon

    International Nuclear Information System (INIS)

    We report the growth of thin ScN layers deposited by plasma-assisted molecular beam epitaxy on Sc2O3/Y2O3/Si(111) substrates. Using x-ray diffraction, Raman spectroscopy, and transmission electron microscopy, we find that ScN films grown at 600 °C are single crystalline, twin-free with rock-salt crystal structure, and exhibit a direct optical band gap of 2.2 eV. A high degree of crystalline perfection and a very good lattice matching between ScN and GaN (misfit < 0.1%) makes the ScN/Sc2O3/Y2O3 buffer system a very promising template for the growth of high quality GaN layers on silicon

  14. The Influence of Sc and Zr Additions on the Microstructure and Mechanical Behavior of Ultrafine Grained Al-Mg Alloys Processed by Powder Metallurgy

    Science.gov (United States)

    Harrell, Tammy Jeanne

    Additions of Sc and Zr to an Al-Mg matrix were investigated, paying particular attention to the influence of Al3Sc precipitates and other dispersoids, as well as grain size, on mechanical behavior. Prior studies have shown that Sc and Zr significantly increase the strength of coarse-grained Al-Mg alloys. Prompted by these findings, we hypothesized that it would be of fundamental and technological interest to study the behavior of Sc additions to an ultra-fine-grained (UFG) microstructure (e.g., 100's nm). Accordingly, we investigate the microstructural evolution and mechanical behavior of four powder metallurgy UFG Al-Mg-Sc-(Zr) compositions and compared the results to those of equivalent fine-grained (FG) compositions - Al-5Mg-0.1Sc, Al-3Mg-0.5Sc, Al-5Mg-0.4Sc and Al-5Mg-0.2Sc-0.2Zr (wt.%). Experimental materials were consolidated by hot isostatic pressing (HIP'ing) followed by extrusion or dual mode dynamic (DMD) forging. Under identical processing conditions, UFG ternary Al-5Mg-0.4Sc materials generate large Al3Sc precipitates with an average diameter of 154 nm and spaced approximately 1 - 3 μm apart, while precipitates in the FG materials have an average diameter of 24 nm and are spaced 50 - 200 nm apart. The strengthening mechanisms are quantitatively evaluated for all materials and it is determined that the greatest strengthening contributions for the UFG and FG materials are dispersion strengthening due to the presence of Mg-rich oxides/nitrides and precipitate strengthening, respectively. Preliminary results suggest that replacing 0.2 wt% Sc with Zr results in higher strength, lower ductility and a change in precipitate distribution.

  15. Intramuscular scAAV9-SMN Injection Mediates Widespread Gene Delivery to the Spinal Cord and Decreases Disease Severity in SMA Mice

    OpenAIRE

    Benkhelifa-Ziyyat, Sofia; Besse, Aurore; Roda, Marianne; Duque, Sandra; Astord, Stéphanie; Carcenac, Romain; Marais, Thibaut; Barkats, Martine

    2013-01-01

    We have recently demonstrated the remarkable efficiency of self-complementary (sc) AAV9 vectors for central nervous system (CNS) gene transfer following intravenous delivery in mice and larger animals. Here, we investigated whether gene delivery to motor neurons (MNs) could also be achieved via intramuscular (i.m.) scAAV9 injection and subsequent retrograde transport along the MNs axons. Unexpectedly, we found that a single injection of scAAV9 into the adult mouse gastrocnemius (GA) mediated ...

  16. Effect of Sc{sub 2}O{sub 3} particles on the microstructure and properties of tungsten alloy prepared by spark plasma sintering

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hong-Yu [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); Luo, Lai-Ma, E-mail: luolaima@126.com [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China); Chen, Jing-Bo [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); Li, Ping [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China); Luo, Guang-Nan [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Cheng, Ji-Gui [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China); Wu, Yu-Cheng, E-mail: ycwu@hfut.edu.cn [School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 (China); National–Local Joint Engineering Research Centre of Nonferrous Metals and Processing Technology, Hefei 230009 (China)

    2015-07-15

    Highlights: • Effect of Sc{sub 2}O{sub 3} on microstructure and properties of tungsten alloy were studied. • Sc{sub 2}O{sub 3} significantly refined the grain size and increased the density of tungsten alloy. • The tensile strength values of the W–2 vol%Sc{sub 2}O{sub 3} samples were higher than the others. - Abstract: W–Sc{sub 2}O{sub 3} composite powders (W, W–0.5 vol%Sc{sub 2}O{sub 3}, and W–2 vol%Sc{sub 2}O{sub 3}) doped with highly uniform Sc{sub 2}O{sub 3} particles were successfully synthesized by mechanical alloying followed by hydrogen reduction with Sc{sub 2}O{sub 3} and WO{sub 3} powders. The reduced powders were then consolidated by spark plasma sintering at 1700 °C to suppress grain growth during sintering. Field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and high-resolution transmission electron microscopy analyses, as well as tensile tests and thermal conductivity measurements, were used to characterize the samples. The results showed that the Sc{sub 2}O{sub 3} particles were uniformly distributed in the tungsten grains and grain boundaries. The W–2vol%Sc{sub 2}O{sub 3} composite possess the best relative density and Vickers micro-hardness up to 98.6% and 683.2 Hv, respectively. The Sc{sub 2}O{sub 3} particles significantly refine the grain size and increase the density of tungsten alloy. With increased Sc{sub 2}O{sub 3} content, the thermal conductivity decreased while tensile strength of the samples respectively increased at 700 and 800 °C.

  17. Crystal structure of the Sc{sub 2}PbX{sub 4} (X = S and Se) compounds

    Energy Technology Data Exchange (ETDEWEB)

    Shemet, V.Ya. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave. 13, 43009 Lutsk (Ukraine); Gulay, L.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave. 13, 43009 Lutsk (Ukraine)]. E-mail: gulay@lab.univ.lutsk.ua; Stepien-Damm, J. [W. Trzebiatowski Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wroclaw (Poland); Pietraszko, A. [W. Trzebiatowski Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950 Wroclaw (Poland); Olekseyuk, I.D. [Department of General and Inorganic Chemistry, Volyn State University, Voli Ave. 13, 43009 Lutsk (Ukraine)

    2006-01-05

    The crystal structure of the Sc{sub 2}PbX{sub 4} (X = S and Se) compounds (space group Pnma, Pearson symbol oP28) were determined by means of X-ray single crystal diffraction (a = 1.1642(4) nm, b = 0.3757(1) nm, c = 1.3711(4) nm, R {sub 1} = 0.0420 (Sc{sub 2}PbS{sub 4})) and X-ray powder diffraction (a = 1.22029(5) nm, b 0.39061(2) nm, c = 1.42801(6) nm, R {sub Bragg} = 0.0954 (Sc{sub 2}PbSe{sub 4})). Both compounds crystallize in the CaFe{sub 2}O{sub 4} structure type. The Sc-centered octahedra and Pb-centered trigonal prisms with two additional atoms form columns along the Y-axis in the structure of the Sc{sub 2}PbX{sub 4} (X = S and Se) compounds.

  18. The pyrochlore-type molybdate Pr2Mo1.73Sc0.27O7

    Directory of Open Access Journals (Sweden)

    Philippe Gall

    2012-12-01

    Full Text Available Dipraseodymium molybdenum scandium heptaoxide, Pr2Mo1.73Sc0.27O7, crystallizes in the cubic pyrochlore-type structure. In the crystal, (Mo,ScO6 octahedra are linked together by common corners, forming a three-dimensional [(Mo,Sc2O6] framework. The Pr atom and another O atom atom are located in the voids of this framework. The Mo and the Sc atom are distributed statistically over the same 16d crystallographic position, with site-occupancy factors of 0.867 (3 and 0.133 (3, respectively. The Pr3+ ions are surrounded by six O atoms from the MoO6 octahedra and by two other O atoms, forming a ditrigonal scalenohedron. All atoms lie on special positions. The Pr and the statistically distributed (Mo,Sc sites are in the 16c and 16d positions with .-3m symmetry, and two O atoms are in 48f and 8a positions with 2.mm and -43m site symmetry, respectively.

  19. K2SC: Flexible systematics correction and detrending of K2 light curves using Gaussian Process regression

    CERN Document Server

    Aigrain, Suzanne; Pope, Benjamin

    2016-01-01

    We present K2SC (K2 Systematics Correction), a Python pipeline to model instrumental systematics and astrophysical variability in light curves from the K2 mission. K2SC uses Gaussian process regression to model position-dependent systematics and time-dependent variability simultaneously, enabling the user to remove both (e.g., for transit searches) or to remove systematics while preserving variability (for variability studies). For periodic variables, K2SC automatically computes estimates of the period, amplitude and evolution timescale of the variability. We apply K2SC to publicly available K2 data from campaigns 3--5, showing that we obtain photometric precision approaching that of the original Kepler mission. We compare our results to other publicly available K2 pipelines, showing that we obtain similar or better results, on average. We use transit injection and recovery tests to evaluate the impact of K2SC on planetary transit searches in K2 PDC (Pre-search Data Conditioning) data, for planet-to-star radi...

  20. Selection of scFvs specific for the HepG2 cell line using ribosome display

    Indian Academy of Sciences (India)

    Lei Zhou; Wei-Ping Mao; Juan Fen; Hong-Yun Liu; Chuan-Jing Wei; Wen-Xiu Li; Feng-Yun Zhou

    2009-06-01

    The aim of this study was to construct a ribosome display library of single chain variable fragments (scFvs) associated with hepatocarcinoma and screen such a library for hepatocarcinoma-binding scFvs. mRNA was isolated from the spleens of mice immunized with hepatocellular carcinoma cell line HepG2. Heavy and k chain genes (VH and k) were amplified separately by RT-PCR, and an anti-HepG2 VH/k chain ribosome display library was constructed by assembling VH and k into the VH/k chain with a specially constructed linker by SOE-PCR. The VH/k chain library was transcribed and translated in vitro using a rabbit reticulocyte lysate system. In order to isolate specific scFvs, recognizing HepG2 negative selection on a normal hepatocyte line WRL-68 was carried out before three rounds of positive selection on HepG2. After three rounds of panning, cell enzyme-linked immunosorbent assay (ELISA) showed that one of the scFvs had high affinity for the HepG2 cell and lower affinity for the WRL-68 cell. In this study, we successfully constructed a native ribosome display library. Such a library would prove useful for direct intact cell panning using ribosome display technology. The selected scFv had a potential value for hepatocarcinoma treatment.

  1. Cell Penetrable Human scFv Specific to Middle Domain of Matrix Protein-1 Protects Mice from Lethal Influenza

    Directory of Open Access Journals (Sweden)

    Fonthip Dong-din-on

    2015-01-01

    Full Text Available A new anti-influenza remedy that can tolerate the virus antigenic variation is needed. Influenza virus matrix protein-1 (M1 is highly conserved and pivotal for the virus replication cycle: virus uncoating, assembly and budding. An agent that blocks the M1 functions should be an effective anti-influenza agent. In this study, human scFv that bound to recombinant M1 middle domain (MD and native M1 of A/H5N1 was produced. Phage mimotope search and computerized molecular docking revealed that the scFv bound to the MD conformational epitope formed by juxtaposed helices 7 and 9 of the M1. The scFv was linked molecularly to a cell penetrable peptide, penetratin (PEN. The PEN-scFv (transbody, when used to treat the cells pre-infected with the heterologous clade/subclade A/H5N1 reduced the viral mRNA intracellularly and in the cell culture fluids. The transbody mitigated symptom severity and lung histopathology of the H5N1 infected mice and caused reduction of virus antigen in the tissues as well as extricated the animals from the lethal challenge in a dose dependent manner. The transbody specific to the M1 MD, either alone or in combination with the cognate human scFvs specific to other influenza virus proteins, should be an effective, safe and mutation tolerable anti-influenza agent.

  2. Process boundaries of irreversible scCO2 -assisted phase separation in biphasic whole-cell biocatalysis.

    Science.gov (United States)

    Brandenbusch, Christoph; Glonke, Sebastian; Collins, Jonathan; Hoffrogge, Raimund; Grunwald, Klaudia; Bühler, Bruno; Schmid, Andreas; Sadowski, Gabriele

    2015-11-01

    The formation of stable emulsions in biphasic biotransformations catalyzed by microbial cells turned out to be a major hurdle for industrial implementation. Recently, a cost-effective and efficient downstream processing approach, using supercritical carbon dioxide (scCO2 ) for both irreversible emulsion destabilization (enabling complete phase separation within minutes of emulsion treatment) and product purification via extraction has been proposed by Brandenbusch et al. (2010). One of the key factors for a further development and scale-up of the approach is the understanding of the mechanism underlying scCO2 -assisted phase separation. A systematic approach was applied within this work to investigate the various factors influencing phase separation during scCO2 treatment (that is pressure, exposure of the cells to CO2 , and changes of cell surface properties). It was shown that cell toxification and cell disrupture are not responsible for emulsion destabilization. Proteins from the aqueous phase partially adsorb to cells present at the aqueous-organic interface, causing hydrophobic cell surface characteristics, and thus contribute to emulsion stabilization. By investigating the change in cell-surface hydrophobicity of these cells during CO2 treatment, it was found that a combination of catastrophic phase inversion and desorption of proteins from the cell surface is responsible for irreversible scCO2 mediated phase separation. These findings are essential for the definition of process windows for scCO2 -assisted phase separation in biphasic whole-cell biocatalysis. PMID:26012371

  3. A crystalline anionic complex of scandium nitride endometallofullerene: experimental observation of single-bonded (Sc3N@Ih-C80(-))2 dimers.

    Science.gov (United States)

    Konarev, Dmitri V; Zorina, Leokadiya V; Khasanov, Salavat S; Popov, Alexey A; Otsuka, Akihiro; Yamochi, Hideki; Saito, Gunzi; Lyubovskaya, Rimma N

    2016-09-14

    Reduction of scandium nitride clusterfullerene, Sc3N@Ih-C80, by sodium fluorenone ketyl in the presence of cryptand[2,2,2] allows the crystallization of the {cryptand[2,2,2](Na(+))}2(Sc3N@Ih-C80(-))2·2.5C6H4Cl2 (1) salt. The Sc3N@Ih-C80˙(-) radical anions are dimerized to form single-bonded (Sc3N@Ih-C80(-))2 dimers. PMID:27511304

  4. SC2IT: a cloud computing interface that makes computational science available to non-specialists

    Science.gov (United States)

    Jorissen, Kevin; Vila, Fernando; Rehr, John

    2012-10-01

    Computational work is a vital part of much scientific research. In materials science research in particular, theoretical models are usually needed to understand measurements. There is currently a double barrier that keeps a broad class of researchers from using state-of-the-art materials science (MS) codes: the software typically lacks user-friendliness, and the hardware requirements can demand a significant investment, e.g. the purchase of a Beowulf cluster. Scientific Cloud Computing (SCC) has the potential to breach this barrier and make computational science accessible to a wide class of non-specialists scientists. We present a platform, SC2IT, that enables seamless control of virtual compute clusters in the Amazon EC2 cloud and is designed to be embedded in user-friendly Java GUIs. Thus users can create powerful High-Performance Computing systems with preconfigured MS codes in the cloud with a single mouse click. We present applications of our SCC platform to the materials science codes FEFF9, WIEN2k, and MEEP-mpi. SC2IT and the paradigm described here are applicable to other fields of research beyond materials science, although the computational performance of Cloud Computing may vary with the characteristics of the calculations.

  5. Theoretical Study on the Mechanism of the Gas-phase Reaction of Sc+ with Propargyl Alcohol

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yi-Ping; CHEN Hong-Yan; CHENG Wei-Xian; FENG Yu; YANG Li-Jun

    2008-01-01

    In order to elucidate the reaction mechanisms of reaction Sc+ with propargyl alcohol(PPA),the triplet potential energy surface for the reactions has been theoretically investigated using a DFT method.The geometries for the reactants,intermediates,transition states and products were completely optimized at B3LYP/DZVP level.The single point energy of each stationary point was calculated at MP4/(6-311+G** for C,H,O and Lanl2dz for Sc+)level.All the transition states were verified by the vibrational analysis and the internal reaction coordinate(IRC)calculations.The present results show that the reaction takes an insertion-elimination mechanism both along the O-H and C-O bond activation branches,but the C-O bond activation is much more favorable in energy than the O-H bond activation.All theoretical results not only support the existing conclusions inferred from early experiment,but also complement the pathway and mechanism for this reaction.

  6. Origins of non-stoichiometry in compounds: vacancy-ordering in ScS

    Science.gov (United States)

    Hart, Gus L. W.; Zunger, Alex

    2001-03-01

    While most stable compounds have fixed Daltonian ratios of their constituents (e.g., 1:1 ratio in ZnS, NaCl, GaAs), some materials exhibit significant nonstoichiometry even at low temperatures. Examples include some NaCl-structure transition-metal monochalcogenides such as HfS, ZrSe, and YS. The prototype system ScS exhibits this peculiar property of preferring the presence of vacancies (up to 30%) over a purely stoichiometric structure. Moreover, these vacancies order spatially in unusual structures. We consider Sc_1-xBox _xS as a binary alloy (where Box denotes a vacancy) and express the energy E_MBCE(σ) of any of the 2^N configurations σ in a ``mixed-basis cluster expansion'' (MBCE) obtained from ab initio calculations of ~ 30 ordered structures. A ground state search of all possible configurations reveals that indeed an ordered array of vacancies has the lowest energy. We show systematic features in the electronic structure that help explain the preference for vacancies.

  7. First-principles predicted low-energy structures of NaSc(BH4)4

    Science.gov (United States)

    Tran, Huan Doan; Amsler, Maximilian; Botti, Silvana; Marques, Miguel A. L.; Goedecker, Stefan

    2014-03-01

    According to previous interpretations of experimental data, sodium-scandium double-cation borohydride NaSc(BH4)4 crystallizes in the crystallographic space group Cmcm where each sodium (scandium) atom is surrounded by six scandium (sodium) atoms. A careful investigation of this phase based on ab initio calculations indicates that the structure is dynamically unstable and gives rise to an energetically and dynamically more favorable phase with C2221 symmetry and nearly identical x-ray diffraction pattern. By additionally performing extensive structural searches with the minima-hopping method we discover a class of new low-energy structures exhibiting a novel structural motif in which each sodium (scandium) atom is surrounded by four scandium (sodium) atoms arranged at the corners of either a rectangle with nearly equal sides or a tetrahedron. These new phases are all predicted to be insulators with band gaps of 7.9-8.2 eV. Finally, we estimate the influence of these structures on the hydrogen-storage performance of NaSc(BH4)4.

  8. Compton X-Ray Generation at the KAERI SC RF LINAC

    CERN Document Server

    Park, S H; Jeong, Y U; Lee, B C; Lee, K

    2005-01-01

    The KAERI SC RF linac with one 352 MHz cryomodule is routinely operating at 10 MeV. The maximum accelerating gradient achieved so far is about 7.7 MV/m and is expected to increase up to 9 MV/m, if thermal loss and/or vibration instability is sufficiently suppressed. As a next step, we plan to generate Compton X-rays using external lasers at the straight section, just after the SC linac. This beamline will be relocated to downstream next to undulator beamline for a FEL, when the recirculating beamline is built. In this presentation, we estimate the parameters of Compton X-rays at a given system and suggest the new scheme to increase the flux, or to generate fs X-ray pulses using electron beams with a few tens ps pulse duration, using an intense ultra-short laser. We discussed a coherent condition for Relativistic Nonlinear Thomson Scattered (RNTS) radiation (or Nonlinear Compton Scattered radiation).

  9. Synthetically Control of a Hybrid PV/FC/SC Power System for Stand-Alone Applications

    Directory of Open Access Journals (Sweden)

    Dakang Zhu

    2013-02-01

    Full Text Available In this study, a simple and practical control scheme for power assignment and load-following of a Hybrid Power System (HPS is proposed. The system consists of Photovoltaic (PV, Fuel Cell (FC, Super-Capacitor (SC, dc load, ac load and different kinds of converters. PV is chosen as a prior source, which normally operates in Maximum Power Point Tracking (MPPT mode. In order to achieve 24 h power supply under various natural conditions, FC is used as a backup source to provide the power deficit between solar generation and load demand. Taking the slow FC system dynamics into account, FC power slope has been limited to protect FC from fuel starvation, whereas SC is chosen to satisfy the requirement of the sudden load and solar radiation changes. Besides, a V/f controller is designed to meet ac load demand, while keeping the voltage and frequency within an acceptable range. All the details of this study, including system structure, control diagrams and MATLAB simulation results, are presented.

  10. A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity.

    Directory of Open Access Journals (Sweden)

    Xuelian Bai

    Full Text Available The present work describes the construction and validation of a human scFv library with a novel design approach to synthetic complementarity determining region (CDR diversification. The advantage of synthetic antibody libraries includes the possibility of exerting fine control over factors like framework sequences, amino acid and codon usage, and CDR diversity. However, random combinatorial synthesis of oligonucleotides for CDR sequence diversity also produces many clones with unnatural sequences and/or undesirable modification motifs. To alleviate these issues, we designed and constructed a novel semi-synthetic human scFv library with non-combinatorial, pre-designed CDR diversity and a single native human framework each for heavy, kappa, and lambda chain variable domains. Next-generation sequencing analysis indicated that the library consists of antibody clones with highly nature-like CDR sequences and the occurrence of the post-translational modification motifs is minimized. Multiple unique clones with nanomolar affinity could be isolated from the library against a number of target antigens, validating the library design strategy. The results demonstrate that it is possible to construct a functional antibody library using low, non-combinatorial synthetic CDR diversity, and provides a new strategy for the design of antibody libraries suitable for demanding applications.

  11. Virtual microscopy in medical research: Open European Nephrology Science Center (OpEN.SC)

    Science.gov (United States)

    Schrader, Thomas; Beil, Michael; Schmidt, Danilo; Dietel, Manfred; Lindemann, Gabriela

    2007-03-01

    The amount and heterogeneity of data in biomedical research, notably in transnational research, requires new methods for the collection, presentation and analysis of information. Important data from laboratory experiments as well as patient trials are available as images. Thus, the integration and processing of image data represent a crucial component of information systems in biomedical research. The Charité Medical School in Berlin has established a new information service center for kidney diseases and transplantation (Open European Nephrology Science Centre - OpEN.SC) together with the German Research Agency (DFG). The aims of this project are (i) to improve the availability of raw data, (ii) to establish an infrastructure for clinical trials, (iii) to monitor the occurrence of rare disease patterns and (iv) to establish a quality assurance system. Major diagnostic procedures in medicine are based on the processing and analysis of image data. In diagnostic pathology, the availability of automated slide scanners provide the opportunity to digitize entire microscopic slides. The processing, presentation and analysis of these image data are called virtual microscopy. The integration of this new technology into the OpEN.SC system and the link to other heterogeneous data of individual patients represent a major technological challenge. Thus, new ways in communication between clinical and scientific partners have to be established and will be promoted by the project. The technological basis of the repository are web services for a scalable and adaptable system. HL7 and DICOM are considered the main medical standards of communication.

  12. Characterization of semi-solid processing of aluminium alloy 7075 with Sc and Zr additions

    Energy Technology Data Exchange (ETDEWEB)

    Rogal, Ł., E-mail: l.rogal@imim.pl [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Dutkiewicz, J. [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Atkinson, H.V. [The University of Leicester, Department of Engineering University Road, Leicester, LE1 7RH (United Kingdom); Lityńska-Dobrzyńska, L.; Czeppe, T. [Institute of Metallurgy and Materials Science of the Polish Academy of Sciences, 25 Reymonta St., 30-059 Krakow (Poland); Modigell, M. [RWTH Aachen—Department of Mechanical Process Engineering, 55 Templergraben St., Aachen (Germany)

    2013-09-15

    For thixoforming (semi-solid processing) it is necessary to have a fine globular microstructure in a semi-solid range. Here this has been obtained for 7075 aluminium alloy by addition of modifying agents: 0.5 weight % of scandium and zirconium. The thixoforming process was carried out at 632 °C which gave about 23 volume % of liquid phase. The microstructure of the thixo-formed part (a rotor) consisted of globular grains surrounded by precipitates of secondary phase. The average hardness of thixo-formed parts was 105 HV{sub 5} and the tensile strength 300 MPa. T6 heat treatments were performed with solutionisation at 450 °C for 30 min and 10 h. In both cases the ageing time was set as 18 h at 120 °C. The heat treatments led to an increase in average tensile strength up to 495 MPa. Transmission Electron Microscopy (TEM) analysis enabled the identification of precipitates of the metastable dispersoids of L1{sub 2}–Al{sub 3} (Zr, Sc) and η′ (MgZn{sub 2}) phases in the alloy after the thixoforming and T6 treatment. The measurements of rheological properties of 7075Al alloy with Sc and Zr additions in the semi-solid range indicated an increase of particle size and spheroidization leading to an observable decrease of viscosity during isothermal shearing. A shear rate jump experiment showed that with increasing shear rate the viscosity rapidly falls.

  13. Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intake.

    Science.gov (United States)

    Dess, Nancy K; Chapman, Clinton D; Monroe, Derek

    2009-03-01

    Mammals' affinity for sweet tastes exists alongside dramatic variation among species and individuals in responses to sweeteners. The present paper focused on consumption by Occidental High- (HiS) and Low-Saccharin (LoS)-consuming rats in 23-h 2-bottle tests of 2 sweeteners for which few data from rats are available: SC45647 and sucralose. Every HiS and LoS rat preferred SC45647 to water at every concentration, with HiS rats consuming it more avidly. Most HiS rats preferred sucralose to water at one or more concentrations; some HiS rats and most LoS rats avoided sucralose at every concentration. However, both HiS and LoS rats preferred a sucralose-maltodextrin mixture (Splenda) to water; thus, Splenda's "bulking" ingredient maltodextrin transforms highly variable responses to sucralose into a relatively homogeneous preference for the product. Implications for the study of variation in sweet taste are discussed. PMID:19129238

  14. The elemental composition of the Sun II. The iron group elements Sc to Ni

    CERN Document Server

    Scott, Pat; Grevesse, Nicolas; Bergemann, Maria; Sauval, A Jacques

    2014-01-01

    We redetermine the abundances of all iron group nuclei in the Sun, based on neutral and singly-ionised lines of Sc, Ti, V, Mn, Fe, Co and Ni in the solar spectrum. We employ a realistic 3D hydrodynamic model solar atmosphere, corrections for departures from local thermodynamic equilibrium (NLTE), stringent line selection procedures and high quality observational data. We have scoured the literature for the best quality oscillator strengths, hyperfine constants and isotopic separations available for our chosen lines. We find $\\log \\epsilon_\\mathrm{Sc}=3.16\\pm0.04$, $\\log \\epsilon_\\mathrm{Ti}=4.90\\pm0.04$, $\\log \\epsilon_\\mathrm{V}=3.89\\pm0.08$, $\\log \\epsilon_\\mathrm{Cr}=5.62\\pm0.04$, $\\log \\epsilon_\\mathrm{Mn}=5.42\\pm0.04$, $\\log \\epsilon_\\mathrm{Fe}=7.47\\pm0.04$, $\\log \\epsilon_\\mathrm{Co}=4.93\\pm0.05$ and $\\log \\epsilon_\\mathrm{Ni}=6.20\\pm0.04$. Our uncertainties factor in both statistical and systematic errors (the latter estimated for possible errors in the model atmospheres and NLTE line formation). The ...

  15. Radiation-induced frequency transients in AT, BT, and SC cut quartz resonators

    International Nuclear Information System (INIS)

    Earlier studies of transient frequency changes in high-purity swept AT quartz resonators led to the conclusion that impurity-induced effects were small, while the observed changes were qualitatively and quantitatively well characterized in terms of the time changing temperature of the vibrating quartz and its effect on frequency. 5 MHz, AT cut fifth overtone, and BT and SC cut third overtone resonators were prepared from a single stone of Sawyer swept Premium-Q quartz. The resonators were operated in precision ovenized oscillators at or near their turnover temperatures. Pulsed irradiation, at dose levels of the order of 104 rads (Si) per pulse, was accomplished at Sandia. The experimental data display negative frequency transients for the AT cut resonators, positive frequency transients for the BT cut resonators, and very small transient effects for the SC cut resonators. From these experimental results, it is concluded that no measurable impurity-induced frequency changes are observed in this high-purity swept-quartz and that the frequency transients are accurately modelled in terms of transient temperature effects stemming from the thermal characteristics of the resonator structure

  16. Stellar neutron capture cross sections of 41K and 45Sc

    Science.gov (United States)

    Heil, M.; Plag, R.; Uberseder, E.; Bisterzo, S.; Käppeler, F.; Mengoni, A.; Pignatari, M.

    2016-05-01

    The neutron capture cross sections of light nuclei (A neutron poisons. We report on measurements of the neutron capture cross sections of 41K and 45Sc, which were performed at the Karlsruhe 3.7 MV Van de Graaff accelerator via the activation method in a quasistellar neutron spectrum corresponding to a thermal energy of k T =25 keV. Systematic effects were controlled by repeated irradiations, resulting in overall uncertainties of less than 3%. The measured spectrum-averaged data have been used to normalize the energy-dependent (n ,γ ) cross sections from the main data libraries JEFF-3.2, JENDL-4.0, and ENDF/B-VII.1, and a set of Maxwellian averaged cross sections was calculated for improving the s -process nucleosynthesis yields in AGB stars and in massive stars. At k T =30 keV, the new Maxwellian averaged cross sections of 41K and 45Sc are 19.2 ±0.6 mb and 61.3 ±1.8 mb, respectively. Both values are 20% lower than previously recommended. The effect of neutron poisons is discussed for nuclei with A <56 in general and for the investigated isotopes in particular.

  17. Al-Mg-Mn-Sc-Zr合金的断裂韧性%Fracture toughness of Al-Mg-Mn-Sc-Zr alloy

    Institute of Scientific and Technical Information of China (English)

    张飞鹏; 黄晓亚; 徐开东; 房慧; 王新练; 刘雅妹; 张坤书

    2013-01-01

    Plane strain fracture toughness KIC of Al-4.9Mg-0.6Mn-0.2Sc-0.1Zr alloy hot-rolled plate was measured by three points bending samples in L-T and T-L directions.Fracture morphology of the alloy was analyzed by SEM and TEM .The results show that the values of KIC in L-T and T-L directions are 32.66 MPa· m1/2 and 32.03 MPa· m1/2 respectively, which have a discrepancy of 2%, so the plane strain fracture toughness KIC of the alloy hot-rolled plate has weak anisotropy .The facture surfaces in L-T and T-L directions are composed by dimples and tear ridges .Dimple-type plastic fracture mode shows relatively high toughness of the alloy .Crack growth direction in T-L direction parallels to the rolling direction , and crack growths along fracture channel is formed by second-phase particles , so dimples arrangement on the fracture surface has obvious directionality .Crack growth direction in L-T direction is perpendicular to the rolling direction, so directionality of dimples arrangement in L-T direction is weak.Coarse Al6Mn as crack origins is detrimental for the fracture toughness.Micro-meter Al6Mn particles can cause micro-cracks as well.Nano-meter Al3Sc particles stabilize sub-structures by pinning dislocations and grain boundaries and reduce the dislocation density in front of the sub -grain boundaries , so the fracture toughness of the alloy hot-rolled plate is improved .%采用标准三点弯曲试样测试了Al-4.9Mg-0.6Mn-0.2Sc-0.1Zr合金热轧板L-T和T-L取向平面应变断裂韧度KIC ,并对试样断口进行SEM和TEM分析。结果表明,Al-4.9Mg-0.6Mn-0.2Sc-0.1Zr合金热轧板L-T和T-L取向KIC值分别为32.66 MPa· m1/2和32.03 MPa· m1/2,两者相差2%,表明试验合金平面应变断裂韧性各向异性差别较小。 L-T和T-L取向的断口表面主要由韧窝和撕裂棱组成,属于韧窝型塑性断裂,说明试验合金韧性比较高。 T-L取向断面裂纹的扩展方向与轧制方向一致,裂纹沿着

  18. Study of Microbiologically Induced Corrosion Action on Al-6Mg-Zr and Al-6Mg-Zr-Sc

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The corrosion behaviors of Al-6Mg-Zr and Al-6Mg-Zr-Sc in the sulfate-reducing bacteria (SRB) solution in anaerobic environment were studied using electrochemical, microbiological, and surface analysis methods. It was found that the oxide film was more compact owing to the addition of Sc resulting in the open circuit potential shifting by about 100mV positively. On the other hand, it was seen that the pitting sensitivity of Al-6Mg-Zr-Sc alloy in SRB solution decreased and its microbiologically influenced corrosion resistance was improved. Pitting corrosion occurring on the surface of the two alloys under the comprehensive action of the metabolism of SRB was observed by SEM. It was obtained by EDS that the corrosion degree increased with time and corrosion was furthered by deposition of the product.

  19. High strength aluminum cast alloy: A Sc modification of a standard Al–Si–Mg cast alloy

    Energy Technology Data Exchange (ETDEWEB)

    Muhammad, Arfan, E-mail: engr.arfan@gmail.com [Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education, School of Material Science and Engineering, Beihang University, Beijing 100191 (China); Xu, Cong; Xuejiao, Wang [Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education, School of Material Science and Engineering, Beihang University, Beijing 100191 (China); Hanada, Shuji [Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan); Yamagata, Hiroshi [Center for Advanced Die Engineering and Technology, Gifu University, 1-1 Yanagido, Gifu City, Gifu 501-1193 (Japan); Hao, LiRong [Hebei Sitong New Metal Material Co., Ltd., Baoding 071105 (China); Chaoli, Ma [Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education, School of Material Science and Engineering, Beihang University, Beijing 100191 (China)

    2014-05-01

    A standard Aluminum–Silicon–Magnesium cast alloy (A357 foundry alloy without Beryllium) modified with different weight percentages of Scandium (Sc), has been studied to evaluate the effects of Sc contents on microstructure and strength. Study has been conducted under optimized parameters of melting, casting and heat treatment. Characterization techniques like optical microscopy, SEM, TEM and tensile testing were employed to analyze the microstructure and mechanical properties. Results obtained in this research indicate that with the increase of Sc contents up to 0.4 wt%, grain size is decreased by 80% while ultimate tensile strength and hardness are increased by 28% and 19% respectively. Moreover along with the increase in strength, elongation to failure is also increased up to 165%. This is quite interesting behavior because usually strength and ductility have inverse relationship.

  20. Magnetism in Sc-doped ZnO with zinc vacancies: A hybrid density functional and GGA + U approaches

    KAUST Repository

    Kanoun, Mohammed

    2012-04-01

    We investigate the zinc vacancy effects on the electronic structures and magnetic properties of Sc-doped ZnO, by performing first-principles calculations within both GGA + U and Heyd-Scuseria-Ernzerhof hybrid functional methods. We find that Sc impurities stabilize considerably Zn vacancies. The electronic and magnetic analysis shows a half metallic ferromagnetic character with a total magnetic moment of 2.01 μ B. The magnetism mainly stems from the O 2p states around the Zn vacancies. Calculations with the hybrid density functional agree with the GGA + U results but give an accurate description of the electronic structure for pure ZnO and Sc-doped ZnO with Zn vacancies. © 2012 Elsevier B.V. All rights reserved.

  1. Nd 3+—Cr 3+ pairs in Gd 3Sc 2Ga 3O 12 garnet crystals

    Science.gov (United States)

    Han, T. P. J.; Scott, M. A.; Jaqué, F.; Gallagher, H. G.; Henderson, B.

    1993-06-01

    Several crystals of Gd 3Sc 2Ga 3O 12 (GSGG) with different concentrations of Nd 3+ and Cr 3+ ions have been grown using the Czochralski technique. Optical absorption and site-selective luminescence spectra have been measured in the wavelength range 350-900 nm at low temperatures (15-77 K). These spectral reveal the presence of Nd 3+ ions in two different crystal field sites. Some Nd 3+ ions substitute for Gd 3+ ions in unit cells in which the central octahedral site is occupied by Sc 3+ ions. However, in a significant fraction of unit cells containing Nd 3+ the central octahedral site is occupied by Cr 3+ ions. These centres are labelled Nd 3+ (Sc 3+ and Nd 3+ (Cr 3+), respectively. The spectroscopic characteristics of these perturbed Nd 3+ centres are reported and their relevance to the enhanced Nd 3+ laser efficiency of Cr 3+:Nd 3+:GSGG relative to Nd 3+:GSGG is discussed.

  2. High strength aluminum cast alloy: A Sc modification of a standard Al–Si–Mg cast alloy

    International Nuclear Information System (INIS)

    A standard Aluminum–Silicon–Magnesium cast alloy (A357 foundry alloy without Beryllium) modified with different weight percentages of Scandium (Sc), has been studied to evaluate the effects of Sc contents on microstructure and strength. Study has been conducted under optimized parameters of melting, casting and heat treatment. Characterization techniques like optical microscopy, SEM, TEM and tensile testing were employed to analyze the microstructure and mechanical properties. Results obtained in this research indicate that with the increase of Sc contents up to 0.4 wt%, grain size is decreased by 80% while ultimate tensile strength and hardness are increased by 28% and 19% respectively. Moreover along with the increase in strength, elongation to failure is also increased up to 165%. This is quite interesting behavior because usually strength and ductility have inverse relationship

  3. SYNTHESIS AND CHARACTERIZATION OF NOVEL CHIRAL SMECTIC C(Sc*) PHASE SHISH-KEBAB TYPE LIQUID CRYSTALLINE BLOCK COPOLYMERS

    Institute of Scientific and Technical Information of China (English)

    Shi-jun Zheng; Zi-fa Li; Shu-yuan Zhang; Shao-kui Cao; Ming-sheng Tang; Qiu-jun Fen; Qi-feng Zhou

    1999-01-01

    A new series of chiral shish-kebab type liquid crystal block copolymers that form the smectic C(Sc*) phase was synthesized by solution polycondensation. The copolymers were characterized by GPC,DSC, TG, POM, X-ray diffraction and polarimeter. The copolymers 7 entered into liquid crystal phase when they were heated to their melting temperatures (Tm) and the copolymers 8 were in liquid crystal phase at room temperature with low viscosities. The smectic sanded texture or focal-conic texture were observed on POM.All the chiral block copolymers showed high optical activity. No racemization has happened. Temperaturevariable X-ray diffraction study together with POM and polarimetric analysis realized that they are chiral smectic C(Sc*) phase. Thus we offer in this report the first example of shish-kebab type liquid crystal block copolymers that form a chiral smectic C(Sc*) phase. The variation of melting and isotropization temperatures with molecular structure was also discussed.

  4. Charge Transfer for Reactions of Sc3+ with N2 and H2 at Electron-volt Energy

    Institute of Scientific and Technical Information of China (English)

    CAO Li; JIANG Yu-Rong; NIE Zong-Xiu; LI Jiao-Mei; GAO Ke-Lin

    2001-01-01

    The charge transfer rate coefficients for reactions of Sc3+ with N2 and H2 have been measured at the meancollision energy of 4.2 Ev. The rate coefficients are derived from the decay rate ofion signals by using ion storagein a radio frequency ion trap. The rate coefficients are 8.18(0.18) × 10-10cm3.s-1 at Tequiv ≈ 1.26 × 104K forSc3+ with N2 and 1.44(0.39) × 10-9 cm3.s-1 at Tequiv ≈ 1.67 × 103 K for Sc3+ with H2, respectively. Both resultsare comparablewith the Langevin rate coefficients.

  5. MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.

    Directory of Open Access Journals (Sweden)

    Marin IONICĂ

    2012-12-01

    Full Text Available Through this scientific research report “MANAGEMENT ASPECTS IN THE PERSONNEL REMUNERATION AND STIMULATION ACTIVITIES AT S.C. TASMANIA S.R.L.” we plan to investigate the remuneration and stimulation method from the human resources department within S.C. Tasmania. Studying in detail the personnel’s remuneration and stimulation we have tried to present the main policy aspects at S.C. Tasmania in human resources domain: integration of the human resource management in the overall management of the company, creating a favorable climate for conducting the activities,professional development, evaluation and motivation, employee involvement in the decision making process.We conclude that the development of management theory and practice in personnel remuneration and stimulation in an open field for performance and professionalism of the managerial team of Tasmania S.R.L.

  6. Thermoelectric properties of epitaxial ScN films deposited by reactive magnetron sputtering onto MgO(001) substrates

    Energy Technology Data Exchange (ETDEWEB)

    Burmistrova, Polina V.; Rui Koh, Yee; Lundstrom, Mark S. [School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); Maassen, Jesse; Salamat, Shuaib [School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Favaloro, Tela [School of Engineering, University of California Santa Cruz, Santa Cruz, California 95064 (United States); Saha, Bivas [Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Shakouri, Ali [School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); School of Engineering, University of California Santa Cruz, Santa Cruz, California 95064 (United States); Sands, Timothy D. [School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 (United States); Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States); School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907 (United States)

    2013-04-21

    Epitaxial ScN(001) thin films were grown on MgO(001) substrates by dc reactive magnetron sputtering. The deposition was performed in an Ar/N{sub 2} atmosphere at 2 Multiplication-Sign 10{sup -3} Torr at a substrate temperature of 850 Degree-Sign C in a high vacuum chamber with a base pressure of 10{sup -8} Torr. In spite of oxygen contamination of 1.6 {+-} 1 at. %, the electrical resistivity, electron mobility, and carrier concentration obtained from a typical film grown under these conditions by room temperature Hall measurements are 0.22 m{Omega} cm, 106 cm{sup 2} V{sup -1} s{sup -1}, and 2.5 Multiplication-Sign 10{sup 20} cm{sup -3}, respectively. These films exhibit remarkable thermoelectric power factors of 3.3-3.5 Multiplication-Sign 10{sup -3} W/mK{sup 2} in the temperature range of 600 K to 840 K. The cross-plane thermal conductivity is 8.3 W/mK at 800 K yielding an estimated ZT of 0.3. Theoretical modeling of the thermoelectric properties of ScN calculated using a mean-free-path of 23 nm at 300 K is in very good agreement with the experiment. These results also demonstrate that further optimization of the power factor of ScN is possible. First-principles density functional theory combined with the site occupancy disorder technique was used to investigate the effect of oxygen contamination on the electronic structure and thermoelectric properties of ScN. The computational results suggest that oxygen atoms in ScN mix uniformly on the N site forming a homogeneous solid solution alloy. Behaving as an n-type donor, oxygen causes a shift of the Fermi level in ScN into the conduction band without altering the band structure and the density of states.

  7. Scandium Selenophosphates: Structure and Properties of K4Sc2(PSe4)2(P2Se6).

    Science.gov (United States)

    Syrigos, Jonathan C; Kanatzidis, Mercouri G

    2016-05-01

    The new compound K4Sc2P4Se14 was synthesized via the polychalcogenide flux method. It crystallizes in the space group C2/c, and the structure is composed of (1)/∞[Sc2P4Se14(4-)] chains that are separated by K(+) cations. The structural motif features two [PSe4](3-) units and one [P2Se6](4-) unit bridging the Sc centers and has not been reported for any other compound. The (1)/∞[Sc2P4Se14(4-)] chains pack in a crosshatched pattern perpendicular to the c axis of the crystal, forming channels for half of the K(+) atoms while the other half occupy empty space between the chains. The orange-yellow crystals of K4Sc2P4Se14 are air-sensitive and gradually turn red over the course of a couple hours. The band gap of the phase is 2.25(2) eV, and Raman spectroscopy shows the symmetric stretches of the selenophosphate groups to be at 231 and 216 cm(-1) for the [PSe4](3-) and [P2Se6](4-) units, respectively. Solid-state (31)P MAS NMR of K4Sc2P4Se14 shows two prominent peaks at 11.31 and -23.07 ppm and one minor peak at -106.36 ppm, most likely due to degradation of the product or an unknown second phase. PMID:27078201

  8. Selection of anti-sulfadimidine specific ScFvs from a hybridoma cell by eukaryotic ribosome display.

    Directory of Open Access Journals (Sweden)

    Yonghua Qi

    Full Text Available BACKGROUND: Ribosome display technology has provided an alternative platform technology for the development of novel low-cost antibody based on evaluating antibiotics derived residues in food matrixes. METHODOLOGY/PRINCIPAL FINDINGS: In our current studies, the single chain variable fragments (scFvs were selected from hybridoma cell lines against sulfadimidine (SM(2 by using a ribosome library technology. A DNA library of scFv antibody fragments was constructed for ribosome display, and then mRNA-ribosome-antibody (MRA complexes were produced by a rabbit reticulocyte lysate system. The synthetic sulfadimidine-ovalbumin (SM(2-OVA was used as an antigen to pan MRA complexes and putative scFv-encoding genes were recovered by RT-PCR in situ following each panning. After four rounds of ribosome display, the expression vector pCANTAB5E containing the selected specific scFv DNA was constructed and transformed into Escherichia coli HB2151. Three positive clones (SAS14, SAS68 and SAS71 were screened from 100 clones and had higher antibody activity and specificity to SM(2 by indirect ELISA. The three specific soluble scFvs were identified to be the same molecular weight (approximately 30 kDa by Western-blotting analysis using anti-E tag antibodies, but they had different amino acids sequence by sequence analysis. CONCLUSIONS/SIGNIFICANCE: The selection of anti-SM(2 specific scFv by in vitro ribosome display technology will have an important significance for the development of novel immunodetection strategies for residual veterinary drugs.

  9. The first principle study of Ni{sub 2}ScGa and Ni{sub 2}TiGa

    Energy Technology Data Exchange (ETDEWEB)

    Özduran, Mustafa [Ahi Evran Üniversitesi Fen Edebiyat Fakültesi Fizik Bölümü, Kırşehir (Turkey); Turgut, Kemal [Yüksek Lisans Öğrencisi, Kırşehir (Turkey); Arikan, Nihat [Ahi Evran Üniversitesi Eğitim Fakültesi İlköğretim Bölümü, Kırşehir (Turkey); İyigör, Ahmet; Candan, Abdullah [Ahi Evran Üniversitesi Merkezi Araştırma Laboratuvarı, Kırşehir (Turkey)

    2014-10-06

    We computed the electronic structure, elastic moduli, vibrational properties, and Ni{sub 2}TiGa and Ni{sub 2}ScGa alloys in the cubic L2{sub 1} structure. The obtained equilibrium lattice constants of these alloys are in good agreement with available data. In cubic systems, there are three independent elastic constants, namely C{sub 11}, C{sub 12} and C{sub 44}. We calculated elastic constants in L2{sub 1} structure for Ni{sub 2}TiGa and Ni{sub 2}ScGa using the energy-strain method. The electronic band structure, total and partial density of states for these alloys were investigated within density functional theory using the plane-wave pseudopotential method implemented in Quantum-Espresso program package. From band structure, total and projected density of states, we observed metallic characters of these compounds. The electronic calculation indicate that the predominant contributions of the density of states at Fermi level come from the Ni 3d states and Sc 3d states for Ni{sub 2}TiGa, Ni 3d states and Sc 3d states for Ni{sub 2}ScGa. The computed density of states at Fermi energy are 2.22 states/eV Cell for Ni{sub 2}TiGa, 0.76 states/eV Cell for Ni{sub 2}ScGa. The vibrational properties were obtained using a linear response in the framework at the density functional perturbation theory. For the alloys, the results show that the L2{sub 1} phase is unstable since the phonon calculations have imagine modes.

  10. Effects of zirconium element on the microstructure and deuterium retention of W-Zr/Sc2O3 composites.

    Science.gov (United States)

    Chen, Hongyu; Luo, Laima; Chen, Jingbo; Zan, Xiang; Zhu, Xiaoyong; Xu, Qiu; Luo, Guangnan; Chen, Junling; Wu, Yucheng

    2016-01-01

    Dense W and W-Zr composites reinforced with Sc2O3 particles were produced through powder metallurgy and subsequent spark plasma sintering (SPS) at 1700 °C and 58 MPa. Results showed that the W-1vol.%Zr/2vol.%Sc2O3 composites exhibited optimal performance with the best relative density of up to 98.93% and high Vickers microhardness of approximately 583 Hv. The thermal conductivity of W-Zr/Sc2O3 composites decreased initially and then increased as the Zr content increased. The moderate Zr alloying element could combine well with Sc2O3 particles and W grains and form a solid solution. However, excess Zr element leads to agglomeration in the grain boundaries. W-1vol.%Zr/2vol.%Sc2O3 composite had a good deuterium irradiation resistance very closing to pure tungsten compared with the other Zr element contents of composites. Under 500 K, D2 retention and release of them were similar to those of commercial tungsten, even lower between 400 K to 450 K. Pre-irradiation with 5 keV-He(+) ions to a fluence of 1 × 10(21) He(+)/m(2) resulted in an increase in deuterium retention (deuterium was implanted after He(+) irradiation), thereby shifting the desorption peak to a high temperature from 550 K to 650 K for the W-1vol.%Zr/2vol.%Sc2O3 composite. PMID:27597314

  11. Genome Sequence of the Fish Pathogen Yersinia ruckeri SC09 Provides Insights into Niche Adaptation and Pathogenic Mechanism.

    Science.gov (United States)

    Liu, Tao; Wang, Kai-Yu; Wang, Jun; Chen, De-Fang; Huang, Xiao-Li; Ouyang, Ping; Geng, Yi; He, Yang; Zhou, Yi; Min, Jie

    2016-01-01

    Yersinia ruckeri is the etiologic agent of enteric red mouth disease (ERM), a severe fish disease prevailing in worldwide aquaculture industries. Here we report for the first time the complete genome of Y. ruckeri (Yersinia ruckeri) SC09, a highly virulent strain isolated from Ictalurus punctatus with severe septicemia. SC09 possesses a single chromosome of 3,923,491 base pairs, which contains 3651 predicted protein coding sequences (CDS), 19 rRNA genes, and 79 tRNA genes. Among the CDS, we have identified a Ysa locus containing genes encoding all the components of a type III secretion system (T3SS). Comparative analysis suggest that SC09-Ysa share extensive similarity in sequence, gene content, and gene arrangement with Salmonella enterica pathogenicity island 1 (SPI1) and chromosome-encoded T3SS from Yersinia enterocolitica biotype 1B. Furthermore, phylogenetic analysis shown that SC09-Ysa and SPI1-T3SS belong on the same branch of the phylogenetic tree. These results suggest that SC09-Ysa and SPI1-T3SS appear to mediate biological function to adapt to specific hosts with a similar niche, and both of them are likely to facilitate the development of an intracellular niche. In addition, our analysis also indicated that a substantial part of the SC09 genome might contribute to adaption in the intestinal microenvironment, including a number of proteins associated with aerobic or anaerobic respiration, signal transduction, and various stress reactions. Genomic analysis of the bacterium offered insights into the pathogenic mechanism associated with intracellular infection and intestinal survivability, which constitutes an important first step in understanding the pathogenesis of Y. ruckeri. PMID:27089334

  12. Estudio sobre el uso del sistema de comunicación aumentativo y alternativo SC@UT

    OpenAIRE

    Espejo Cárdenas, Silvia; Carrillo Morales, Aurelia; Fernández López, Álvaro; Rodríguez Fórtiz, María José

    2009-01-01

    Se ha estudiado el uso del SCAA Sc@ut en aulas, y talleres de dos asociaciones, ASPROGRADES de Granada y APROMPSI de Linares, Jaén. Se han planteado dos hipótesis: (1) El uso de Sc@ut en adultos deficientes y en alumnos en edad escolar con todo tipo de patologías, mejora la comunicación, el desarrollo del lenguaje y por tanto el aprendizaje, (2) La mejora de la comunicación lleva consigo la disminución de las conductas disruptivas y desafiantes. Han participado 67 s...

  13. Moments of Macrodiversity SC Receiver with Two Microdiversity EGC Receivers over Gamma Shadowed Rician Multipath Fading Channel

    Directory of Open Access Journals (Sweden)

    Ilija Temelkovski

    2015-08-01

    Full Text Available SC macrodiversity system with dual EGC microdiversity receivers operating over shadowed multipath fading environment is considered. Received signal experiences correlated Gamma long term fading and Rician short term fading. SC macrodiversity receiver reduces Gamma large scale fading effects, while EGC microdiversity receivers mitigate short term fading effects on system performance. Closed form expressions for arbitrary order output moments of macrodiversity structure output signal is evaluated. Numerical results, obtained for arbitrary order output moments are presented graphically to show Gamma long term fading severity effect, correlation coefficient effects and Rician factor effect.

  14. The pseudogap and anisotropic thermal expansion in RMn(4)Al(8) (R = La,Y,Lu and Sc).

    Science.gov (United States)

    Muro, Y; Nakamura, H; Kohara, T

    2006-04-26

    The temperature dependence of the magnetic susceptibility shows a broad maximum at ∼550 and 630 K for LuMn(4)Al(8) and ScMn(4)Al(8), respectively, which can be interpreted as due to the presence of a pseudogap in the effective bands as in LaMn(4)Al(8) and YMn(4)Al(8). The anisotropic thermal expansion observed for RMn(4)Al(8) (R = La, Y, Lu and Sc) and the sensitive volume dependence of the gap width throughout the RMn(4)Al(8) system suggest dominant magnetic coupling in Mn spin chains along the c axis.

  15. Impact of Reduction Parameters on the Initial Performance and Stability of Ni/(Sc)YSZ Cermet Anodes for SOFCs

    DEFF Research Database (Denmark)

    Ebbehøj, Søren Lyng; Ramos, Tania; Mogensen, Mogens Bjerg

    2012-01-01

    temperatures of 850 °C and 1000 °C was evaluated for tape-cast, thin electrolyte, Nickel/8 mol% Yttria-Stabilized Zirconia (Ni/8YSZ) or (Ni/10Sc1YSZ) symmetric cells. High temperature activation produced the lower Ohmic and polarization resistances related to Triple Phase Boundary (TPB) charge transfer...... processes for Ni/10Sc1YSZ cells. The Ni/8YSZ cells behaved oppositely with respect to reduction temperature. A hypothesis is proposed relating performance to variations in Ni microstructure, Ni/ceramic contacting and extent of TPB resulting from differences in reduction parameters. Further, the performance...

  16. Crystal Growth and Properties of Co2+ doped Y3Sc2Ga3O12 Single Crystal

    Institute of Scientific and Technical Information of China (English)

    Guo Shiyi; Yuan Duorong; Shi Xuzhong; Cheng Xiufeng; Zhang Xiqing; Yu Fapeng

    2007-01-01

    Single crystal of cobalt (Co)-doped Y3Sc2Ga3O12 (YSGG) with the dimensions up to φ20×40mm3 and undoped YSGG crystal with the dimensions up to φ28×60mm3 have been grown using the Czochralski technique. The structure of the crystal was characterized by the X-ray powder diffraction (XRPD) method. The absorbance spectra of the crystal shows that it has strong absorption bands at 606 and 1540nm. The results indicate that the crystal Y3Sc2Ga3O12 may be a kind of good Q-switch material.

  17. Production and Evaluation of Immunoreactivity of Poly Lysine-Tagged Single Chain Fragment Variable (ScFv) Lym-1 Antibody for Direct Conjugation to Fluorescence Dye

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jae Ho; Choi, Tae Hyun; Woo, Kwang Sun; Chung, Wee Sup; Kang, Joo Hyun; Jeong, Su Young; Choi, Chang Woon; Lim, Sang Moo; Cheon, Gi Jeong [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2009-10-15

    Small size of recombinant scFv antibody has many advantages such as rapid blood clearances and improved targeting antibodies to tumor region. On the other hand owing to small size, number of amino group is insufficient in conjugation with chelator and fluorescence labeling. This study is to introduce poly lysine tag to the C-terminal end of scFv lym-1 sequence for fluorescence chelator conjugation. Poly lysine scFv lym-1 gene, cloned into pET-22b (+) vector, was expressed in E. coli BL21 (DE3) strain. Antibody purification was performed with Ni-NTA column and then size exclusion column chromatography. Expression and purification levels of poly lysine tagged scFv lym-1 antibody were confirmed by western blot analysis. I-124, I-125, I-131 and Tc-99m were used for radiolabeling of purified poly lysine scFv lym-1. Flow cytometry analysis of FITC conjugated poly lysine scFv lym-1 was performed for confirmation of immunoreactivity of human Burkitt's lymphoma cells. Poly lysine scFv lym-1 antibody was purified through two steps and identified as molecular weight of 48 KDa. Radiolabeling yields of I-124, I-125, I-131 and Tc-99m into poly lysine scFv lym-1 were >99%, >99%, >95% and >99%, respectively. Flow cytometry analysis of poly lysine scFv and scFv lym-1 was showed similar immunoreactivity to human Burkitt's lymphoma cells. Poly lysine tag was useful for the sufficient number of amino groups to scFv lym-1 antibody for chelator conjugation with minimizing loss of immunoreactivity

  18. Production and Evaluation of Immunoreactivity of Poly Lysine-Tagged Single Chain Fragment Variable (ScFv) Lym-1 Antibody for Direct Conjugation to Fluorescence Dye

    International Nuclear Information System (INIS)

    Small size of recombinant scFv antibody has many advantages such as rapid blood clearances and improved targeting antibodies to tumor region. On the other hand owing to small size, number of amino group is insufficient in conjugation with chelator and fluorescence labeling. This study is to introduce poly lysine tag to the C-terminal end of scFv lym-1 sequence for fluorescence chelator conjugation. Poly lysine scFv lym-1 gene, cloned into pET-22b (+) vector, was expressed in E. coli BL21 (DE3) strain. Antibody purification was performed with Ni-NTA column and then size exclusion column chromatography. Expression and purification levels of poly lysine tagged scFv lym-1 antibody were confirmed by western blot analysis. I-124, I-125, I-131 and Tc-99m were used for radiolabeling of purified poly lysine scFv lym-1. Flow cytometry analysis of FITC conjugated poly lysine scFv lym-1 was performed for confirmation of immunoreactivity of human Burkitt's lymphoma cells. Poly lysine scFv lym-1 antibody was purified through two steps and identified as molecular weight of 48 KDa. Radiolabeling yields of I-124, I-125, I-131 and Tc-99m into poly lysine scFv lym-1 were >99%, >99%, >95% and >99%, respectively. Flow cytometry analysis of poly lysine scFv and scFv lym-1 was showed similar immunoreactivity to human Burkitt's lymphoma cells. Poly lysine tag was useful for the sufficient number of amino groups to scFv lym-1 antibody for chelator conjugation with minimizing loss of immunoreactivity

  19. ALERTES-SC3 Early Warning System prototype for South Iberian Peninsula: on-site approach.

    Science.gov (United States)

    Pazos, Antonio; Lopez de Mesa, Mireya; Gallego Carrasco, Javier; Martín Davila, José; Rioja del Rio, Carlos; Morgado, Arturo; Vera, Angel; Ciberia, Angel; Cabieces, Roberto; Strollo, Angelo; Hanka, Winfried; Carranza, Marta

    2016-04-01

    In recent years several Earthquake Early Warning Systems (EEWS) have been developed for different parts of the world. The area between SW Cape St. Vicente and the Strait of Gibraltar is one of the most seismically active zones in the Ibero-Maghrebian region, with predominantly moderate and superficial seismicity, but also big events with associated tsunamis are well documented in the area, like the 1755 Lisbon earthquake. In the frame of the ALERT-ES (2011-2013) and ALERTES-RIM (2014-2016) Spanish projects, the ALERTES-SC3 EEWS, regional approach, prototype has been developed at the Royal Spanish Navy Observatory (ROA) and is being tested in near real time for south Iberia. This prototype, based on the SeisComP3 software package, is largely based on algorithms derived from the analysis of the first seconds of the P wave records. Calculation of several parameters are carried out, mainly the characteristic period (τc) and the displacement peak (Pd), but also the velocity peak (Pv), the maximum period (τPmáx), among others. In order to warm the areas closest to the hypocentre, places located inside the "blind zone", a on-site EEWS has also been developed by ROA and integrated in the ALERTES-SC3 prototype. From the on-site approach, a warm level is declared from one station as a function of the estimated characteristic period (τc) and the displacement Peak (Pd), although the earthquake location and therefore the lead time available remains unknown. This on-site EEWS is being tested in several Western Mediterranean net (WM) stations as ARNO (Arenosillo, Huelva,Spain) or CHAS (Chafarinas island, North Africa, Spain). Also an on-site low cost station is being developed based in low cost accelerometers. In this work the current state of the on-site EEWS developed, its integration in the ALERTES-SC3 EEWS system and the low cost seismic stations are shown.

  20. l2b78sc.m77t - MGD77 data file for Geophysical data from field activity L-2B-78-SC in Southern California from 05/25/1978 to 05/29/1978

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry and magnetics data along with DGPS navigation data was collected as part of field activity L-2B-78-SC in Southern California from 05/25/1978...

  1. f184sc.m77t - MGD77 data file for Geophysical data from field activity F-1-84-SC in Southern California from 04/26/1984 to 05/21/1984

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry and magnetic data along with DGPS navigation data was collected as part of field activity F-1-84-SC in Southern California from 04/26/1984 to...

  2. Anti-ABCG2 scFv antibody of lung adenocarcinoma increases chemosensitivity and induces apoptosis through the activation of mitochondrial pathway.

    Science.gov (United States)

    Zhao, Wen-Si; Luo, Yi; Li, Bo-Yi; Zhou, Han-Jing; Zhang, Tao

    2016-01-01

    ABCG2 is a multidrug resistance efflux pump expressed in many diverse tumors. The overexpression of ABCG2 is associated with resistance to a wide variety of anticancer agents, providing a noticeable setback to successful cancer therapy. Therapies targeting ABCG2 may therefore be a promising candidate for reversal of chemoresistance. The anti-ABCG2 single-chain variable fragment (scFv) antibody was constructed by phage display peptide library technology. Immunoblotting, ELISA and immunocytochemistry were used to evaluate the soluble expression and immunoreactivity of the scFv. The effects of scFv on cell function and chemosensitization were confirmed by colony formation, cell migration and CCK-8 assays. Flow cytometry was used to analyse the cell cycle and apoptosis. Radioimmunoimaging and nude mouse tumorigenicity assays were taken to determine the biodistribution and antitumor capacity of the scFv antibody. We have successfully screened out the candidate scFv antibody with an apparent molecular weight of 34 kDa. The scFv demonstrated favourable binding ability to lung adenocarcinoma cells and ABCG2 antigen, and the radioactivity was specifically aggregated at the tumor location. Furthermore, the internalized scFv resulted in antibody-mediated downregulation of ABCG2, proliferation inhibition, apoptosis and cisplatin (DDP) sensitivity. The anti-ABCG2 scFv antibody possesses good tumoraffin and antitumor activity and may therefore be an effective therapeutic agent for lung adenocarcinoma that is dependent on ABCG2 for drug resistance and survival. PMID:27293996

  3. Mechanical Properties Evaluation of Zr Addition in L12-Al3(Sc1- x Zr x ) Using First-Principles Calculation

    Science.gov (United States)

    Qian, Yi; Xue, Jilai; Wang, Zengjie; Yang, Zhenhai; Qian, Ping

    2016-05-01

    L12-Al3(Sc1- x Zr x ) can be used as a grain refiner and recrystallization inhibitor in forming and heat-treatment of wrought aluminum alloy. In this work, the mechanical properties of L12-Al3(Sc1- x Zr x ) (0 process optimization for Al alloys in forming and heat treatment.

  4. New Insights into the Negative Thermal Expansion: Direct Experimental Evidence for the "Guitar-String" Effect in Cubic ScF3.

    Science.gov (United States)

    Hu, Lei; Chen, Jun; Sanson, Andrea; Wu, Hui; Guglieri Rodriguez, Clara; Olivi, Luca; Ren, Yang; Fan, Longlong; Deng, Jinxia; Xing, Xianran

    2016-07-13

    The understanding of the negative thermal expansion (NTE) mechanism remains challenging but critical for the development of NTE materials. This study sheds light on NTE of ScF3, one of the most outstanding materials with NTE. The local dynamics of ScF3 has been investigated by a combined analysis of synchrotron-based X-ray total scattering, extended X-ray absorption fine structure, and neutron powder diffraction. Very interestingly, we observe that (i) the Sc-F nearest-neighbor distance strongly expands with increasing temperature, while the Sc-Sc next-nearest-neighbor distance contracts, (ii) the thermal ellipsoids of relative vibrations between Sc-F nearest-neighbors are highly elongated in the direction perpendicular to the Sc-F bond, indicating that the Sc-F bond is much softer to bend than to stretch, and (iii) there is mainly dynamically transverse motion of fluorine atoms, rather than static shifts. These results are direct experimental evidence for the NTE mechanism, in which the rigid unit is not necessary for the occurrence of NTE, and the key role is played by the transverse thermal vibrations of fluorine atoms through the "guitar-string" effect. PMID:27336200

  5. 41 CFR 102-38.365 - Is a holding agency required to report property in “scrap” condition to its selected SC?

    Science.gov (United States)

    2010-07-01

    ... Sales Program § 102-38.365 Is a holding agency required to report property in “scrap” condition to its selected SC? No. Property which has no value except for its basic material content (scrap material) may be... agency should consult the SC(s) selected by the holding agency as to the feasibility of selling the...

  6. Complete Genome Sequence of Paenibacillus polymyxa SC2, a Strain of Plant Growth-Promoting Rhizobacterium with Broad-Spectrum Antimicrobial Activity ▿

    OpenAIRE

    Ma, Mingchao; Wang, Cuicui; Ding, Yanqin; Li, Li; Shen, Delong; Jiang, Xin; Guan, Dawei; Cao, Fengming; Chen, Huijun; Feng, Ruihua; Wang, Xuan; Ge, Yifan; Yao, Liangtong; Bing, Xiaohui; Yang, Xiaohong

    2010-01-01

    Paenibacillus polymyxa SC2 is an important plant growth-promoting rhizobacterium (PGPR). Here, we report the complete genome sequence of P. polymyxa SC2. Multiple sets of functional genes have been found in the genome. As far as we know, this is the first complete genome sequence of Paenibacillus polymyxa.

  7. The UNAM M. Sc. program in Medical Physics enters its teen years

    Science.gov (United States)

    Brandan, María-Ester

    2010-12-01

    The M.Sc. (Medical Physics) program at the National Autonomous University of Mexico UNAM, created in 1997, has graduated a substantial number of medical physicists who constitute today about 30% of the medical physics clinical workforce in the country. Up to present date (May 2010) more than 60 students have graduated, 60% of them hold clinical jobs, 20% have completed or study a Ph.D., and 15% perform activities related to this specialization. In addition to strengthening the clinical practice of medical physics, the program has served as an incentive for medical physics research in UNAM and other centers. We report the circumstances of the program origin, the evolution of its curriculum, the main achievements, and the next challenges.

  8. Effect of deformation structure on fatigue behavior of an Al-Mg-Sc alloy

    Science.gov (United States)

    Zhemchuzhnikova, Daria; Kaibyshev, Rustam

    2014-08-01

    Effect of initial grain size on fatigue behavior of an Al-6%Mg-0.35%Mn-0.2%Sc- 0.08%Zr-0.07%Cr alloy was examined. The initial CG microstructure with an average grain size of ~ 22 μm was manufactured by casting followed by solution treatment at 360 °C for 12 h. To produce the UFG condition, the alloy was subjected to equal-channel angular pressing (ECAP) at 320 °C up to a total strain of ~ 14. Extensive grain refinement provided the formation of fully recrystallized structure with an average grain size of 700 nm. It was shown that the formation of UFG structure provided +60% increases in yield stress and +25% increases in fatigue strength. Fundamentals of this effect of microstructure on the static strength, fatigue resistance and fracture modes are discussed.

  9. Proton and oxide ion conductivity of doped LaScO3

    DEFF Research Database (Denmark)

    Lybye, D.; Bonanos, N.

    1999-01-01

    . At temperatures below 800 degrees C and low partial pressure of oxygen, proton conduction was dominant. Above this temperature, the ionic conductivity is dominated by oxide ion transport. The protonic transport number was estimated from the conductivities measured in dry and in water-moisturised gas. An isotope......The conductivity of La0.9Sr0.1Sc0.9Mg0.1O3 has been studied by impedance spectroscopy in controlled atmospheres. The material was found to be a mixed conductor with p-type conduction at high oxygen partial pressures and a combined proton and oxide ion conductor at low oxygen partial pressures...... effect was observed using D-2/D2O in place of H-2/H2O. The oxygen transport number was estimated from this effect and from measurements in a two-chamber electrochemical cell. (C) 1999 Elsevier Science B.V. All rights reserved....

  10. A theoretical study of the elastic and thermal properties of ScRu compound under pressure

    Science.gov (United States)

    Huang, Shuo; Li, Rui-Zi; Qi, San-Tao; Chen, Bao; Shen, Jiang

    2014-06-01

    The elastic and thermal properties of ScRu under pressure are studied using a first-principles pseudopotential method within the generalized gradient approximation. The calculated lattice parameter and formation enthalpy are in good agreement with the previous experimental and theoretical results. From the static finite strain technique, we obtained three independent elastic constants (C 11, C 12 and C 44) and various secondary elasticity parameters such as shear modulus, Young’s modulus and elastic anisotropy, as functions of pressure. This study also provided the pressure and temperature variations of the bulk modulus, Debye temperature, thermal expansion coefficient and heat capacity in wide pressure (0-60 GPa) and temperature (0-1800 K) ranges.

  11. Thermodynamic assessments of the Fe-Y and Ni-Sc systems

    Directory of Open Access Journals (Sweden)

    Kardellass S.

    2013-07-01

    Full Text Available The present study concerns the optimization of the Fe-Y and Ni-Sc systems by the help of the CALPHAD (CALculation of Phase Diagram method, taking into account the available experimental results about phase equilibria and thermodynamic properties. The excess terms of the Gibbs energy of the solution phases (liquid, b.c.c., f.c.c. and h.c.p. were assessed with the recent exponential temperature dependence of the interaction energies by Kaptay and compared with the linear dependence by Redlich-Kister. Furthermore, the computer program Thermo-Calc allows to obtain estimated data for experimentally undetermined thermodynamic properties and to compare the computed phase diagrams with those already published.

  12. Redesigning Introductory Science Courses to Teach Sustainability: Introducing the L(SC)2 Paradigm

    Science.gov (United States)

    Myers, J. D.; Campbell-Stone, E.; Massey, G.

    2008-12-01

    Modern societies consume vast quantities of Earth resources at unsustainable levels; at the same time, resource extraction, processing, production, use and disposal have resulted in environmental damage severe enough to threaten the life-support systems of our planet. These threats are produced by multiple, integrative and cumulative environmental stresses, i.e. syndromes, which result from human physical, ecological and social interactions with the environment in specific geographic places. In recent decades, recognition of this growing threat has lead to the concept of sustainability. The science needed to provide the knowledge and know-how for a successful sustainability transition differs markedly from the science that built our modern world. Sustainability science must balanced basic and applied research, promote integrative research focused on specific problems and devise a means of merging fundamental, general scientific principles with understanding of specific places. At the same time, it must use a variety of knowledge areas, i.e. biological systems, Earth systems, technological systems and social systems, to devise solutions to the many complex and difficult problems humankind faces. Clearly, sustainability science is far removed from the discipline-based science taught in most U.S. colleges. Many introductory science courses focus on content, lack context and do not integrate scientific disciplines. To prepare the citizens who will confront future sustainability issues as well as the scientists needed to devise future sustainability strategies, educators and scientists must redesign the typical college science course. A new course paradigm, Literacies and Scientific Content in Social Context (L(SC)2), is ideally suited to teach sustainability science. It offers an alternative approach to liberal science education by redefining and expanding the concept of the interdisciplinary course and merging it with the integrated science course. In addition to

  13. A Compton X-ray source based on a SC linac at KAERI

    Science.gov (United States)

    Bondarenko, A. V.; Han, Y. H.; Jeong, Y. U.; Lee, B. C.; Miginsky, S. V.; Park, S. H.

    2007-05-01

    A quasi-monochromatic X-ray source based on a KAERI SC linac system has been designed and is being manufactured now. 10 MeV 10 mA electron beam together with 20 W 1.06 μm laser beam will be used for 1.8 keV Compton X-ray generation with a few percentage of energy spread and 10 7 photons /s flux. A simple straight beamline was designed to deliver the electron beam with no degradation of its emittance and energy spread and to focus it to a proper size to produce the desired X-rays. We expect the first demonstration of 1.8 keV Compton X-ray generation in autumn 2006.

  14. The spatial specificities of SC and ST population in Kolkata city: approaches, techniques and analysis

    Directory of Open Access Journals (Sweden)

    Mishra, Swasti Vardhan

    2012-06-01

    Full Text Available The paper aims at achieving two objectives, firstly, to acquaint the researchers in the field of spatial demography with the techniques of residential segregation; pattern of population distribution based on the concept of spatial statistics and secondly, the practical evaluation of the techniques through real life data. The study queries about any residential segregation and pattern of location of the scheduled caste (SC and the scheduled tribe (ST population in Kolkata city by concentrating on the measures of Entropy Index (EI, Atkinson’s Index, Absolute Centralization Index (ACE and the Global and Local Spatial Autocorrelation (SA measures of Moran’s I and LISA. The outcome of the study clarifies the fact that caste and race based segregation is being diluted in the wake of Indian urbanization and the spatial clustering tendency of the Concerned Social Group (CSG is as mild.

  15. Three New .β-Resorcylic Acid Lactones from Paecflomyces sp. SC0924

    Institute of Scientific and Technical Information of China (English)

    徐良雄; 薛琮花; 邹永; 何树杰; 魏孝义

    2012-01-01

    Three new β-resorcylic acid lactones (RALs), paecilomycins G-I (1--3), and eight known compounds, aigia- lomycins B--D (4--6), 1',2'-epoxy aigialomycin D (7), zearalenone (8), 7'-dehydrozearalenone (9), and trans-7',8'-dehydrozearalenol (10), antibiotic LL-Z1640-1 (11), were isolated from the mycelial solid culture of Paecilomyces sp. SC0924. Their structures were established by spectroscopic methods and chemical means. In an assessment of antifungal activity by the well plate diffusion method, five known RALs, 4-7 and 11 showed weak activities against Peronophythora litchii.

  16. Optical and electronic properties of double perovskite Ba2ScSbO6

    Science.gov (United States)

    Ray, Rajyavardhan; Himanshu, A. K.; Lahiri, J.; Kumar, Uday; Sen, Pintu; Bandyopadhyay, S. K.; Sinha, T. P.

    2016-05-01

    The ordered double perovskite Ba2ScSbO6 (BSS) has been synthesized in polycrystalline form by solid state reaction at 1400 C for 72 Hrs. Structural characterization of the compound was done through X-ray diffraction (XRD) followed by Rietveld analysis. The crystal structure is cubic, with space group Fm-3m (No. 225) and lattice parameter, a = 8.20 Ǻ. Optical band-gap has been calculated using UV-Vis Spectroscopy and Kubelka-Munk (KM) function, yielding 4.23 eV. A detailed Ab-initio Density Functional Theory (DFT) study of the electronic properties has been carried out using the Full-Potential Linear Augmented Plane Wave (FP-LAPW) as implemented in WIEN2k. BSS is found to be a large band-gap insulator with potential technological applications.

  17. Density functional calculations on 13-atom Pd12M (M=Sc-Ni) bimetallic clusters

    Institute of Scientific and Technical Information of China (English)

    Tang Chun-Mei; Chen Sheng-Wei; Zhu Wei-Hua; Tao Cheng-Jun; Zhang Ai-Mei; Gong Jiang-Feng; Zou Hua; Liu Ming-Yi; Zhu Feng

    2012-01-01

    The geometric structures,electronic and magnetic properties of the 3d transition metal doped clusters Pd12M (M =Sc Ni) are studied using the semi-core pseudopots density functional theory.The groundstate geometric structure of the Pd12M cluster is probably of pseudoicosahedron.The Ih-Pd12M cluster has the most thermodynamic stability in five different symmetric isomers.The energy gap shows that Pd12M cluster is partly metallic.Both the absolutely predominant metal bond and very weak covalent bond might exist in the Pd12M cluster.The magnetic moment of Pd12M varies from 0 to 5 μB' implying that it has a potential application in new nanomaterials with tunable magnetic properties.

  18. Effect of Grain Refinement on Jerky Flow in an Al-Mg-Sc Alloy

    Science.gov (United States)

    Mogucheva, Anna; Yuzbekova, Diana; Kaibyshev, Rustam; Lebedkina, Tatiana; Lebyodkin, Mikhail

    2016-05-01

    The influence of microstructure on the manifestations of the Portevin-Le Chatelier (PLC) effect was studied in an Al-Mg-Sc alloy with unrecrystallized, partially recrystallized, and fully recrystallized grain structures. It was found that the extensive grain refinement promotes plastic instability: the temperature-strain rate domain of the PLC effect becomes wider and the critical strain for the onset of serrations decreases. Besides, the amplitude of regular stress serrations observed at room temperature and an intermediate strain rate increases several times, indicating a strong increase of the contribution of solute solution hardening to the overall strength. Moreover, the grain refinement affects the usual sequence of the characteristic types of stress serrations, which characterize the dynamical mechanisms governing a highly heterogeneous unstable plastic flow. Finally, it reduces the strain localization and surface roughness and diminishes the difference between the surface markings detected in the necked area and in the region of uniform elongation.

  19. Multiuser subcarriers and bit allocation combining adaptive mapping for SC-FDMA system

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yu-mei; XIN Yu; YANG Da-cheng

    2008-01-01

    In this article, a multiuser single carrier frequency division multiple access (SC-FDMA) system is considered, based on which an adaptive subcarrier and bit allocation algorithm is investigated. The algorithm has been used to achieve a subcarrier mapping mode in this system, which combines the advantages of single- and multi-carrier transmissions, such as, low peak to average power ratio, orthogonality of signals of different users, and low complexity. Simulation results show that it has a similar performance as that of the adaptive allocation algorithm in the orthogonal frequency division multiple (OFDM) system and the proposed mapping mode has a performance gain over the two existing mapping modes at the link level.

  20. Christophe Apprill, Tango. Le couple, le bal et la scène

    OpenAIRE

    Célérier, Laure

    2011-01-01

    « On chuchote qu'il se danse les yeux dans les yeux, qu'il est né dans les bas-fonds et les bordels de Buenos Aires, » on murmure que « le tango est une danse de macho, qu'il est un désir horizontal exprimé à la verticale », écrit Christophe Apprill, sociologue autant que danseur, dans l'introduction de son ouvrage Tango - le couple, le bal et la scène, paru aux Editions Autrement en 2008. L'aura mystérieuse entourant la danse argentine du tango suscite d'innombrables légendes et mythologies....

  1. MAPEAMENTO DA SUSCEPTIBILIDADE A DESLIZAMENTOS NA BACIA HIDROGRÁFICA DO CAETÉ, ALFREDO WAGNER/SC

    Directory of Open Access Journals (Sweden)

    Leandro Redin Vestena

    2010-01-01

    Full Text Available Este artículo tiene como objetivo identifi car y mapear la susceptibilidad de deslizamientos de tierra en la cuenca hidrográfi ca del municipio de Caeté Alfredo Wagner/SC, región montañosa del Estado de Santa Catarina. Se utilizó el modelo SINMAP (Stability Index Mapping para determinar el indice de estabilidad de taludes por medio de la combinación de un modelo hidrológico con un de estabilidad de taludes. Los resultados obtenidos mostran la presencia de zonas con elevado grado de inestabilidad de las laderas y con grado de estabilidad intermedia, que pueden ser fácilmente alteradas por actividades humanas, principalmente por la eliminación de la cubertura vegetal. El conocimiento previo de las zonas susceptibles a deslizamientos y resbalos subvencionan acciones de prevención y mitigación.

  2. AB INITIO CALCULATION OF THE ELASTIC AND OPTICAL PROPERTIES OF AL3SC COMPOUND

    Institute of Scientific and Technical Information of China (English)

    M. Song; D.H. Xiao

    2007-01-01

    The ab initio method has been performed to explore the elastic and optical properties of Al3Sccompound, based on a plane wave pseudopotential method. It can be seen that the calculatedequilibrium lattice parameter and elastic constants are in reasonable agreement with the previousexperimental data. The elastic constants satisfy the requirement for mechanical stability in the cubicstructure of the Al3Sc compound. The optical property calculations show that a strong absorptivepeak exists from 0-15eV and a relative small absorptive peak exists around 30eV. The form iscaused by the optical transitions between high s, p, and d bands, and the latter results from theoptical transitions from high s, p, and d bands to the low 2p band.

  3. Chevaliers de la scène à l’écran

    Directory of Open Access Journals (Sweden)

    Sandra Gorgievski

    2012-08-01

    Full Text Available Le metteur en scène et acteur français Denis Llorca a dirigé le Centre dramatique national de Franche-Comté (1982-1991, avec lequel il a monté d’audacieux spectacles au texte dense, à la durée inhabituelle pour le spectateur moderne : Kings (1978 d’après Shakespeare [dix heures] ; Eux, les possédés (1982 d’après Dostoïevski [huit heures], ou encore Quatre Saisons pour les Chevaliers de la Table Ronde (1989 d’après la légende arthurienne [12 heures]. Avec sa propre compagnie, il a ensuite porté à la scène un projet de sept spectacles s’inspirant des mystères médiévaux, avec des textes empruntés à la Torah, aux Évangiles et au Coran, où le sublime se mêle au grotesque. Dans cet entretien, le réalisateur revient sur ses multiples visions du Moyen Âge dans sa recréation du mythe arthurien au théâtre, mais aussi à l’écran, dans le film qu’il a tiré de la pièce: Les Chevaliers de la Table Ronde (1990 avec Maria Casarès, Alain Cuny et Michel Vitold.

  4. Fabrication and characterization of a new high density Sc/Si multilayer sliced grating

    Energy Technology Data Exchange (ETDEWEB)

    Advanced Light Source; Voronov, Dmitriy L.; Cambie, Rossana; Gullikson, Eric; Yashchuk, Valeriy; Padmore, Howard; Pershin, Yuri; Ponomarenko, Alexander; Kondratenko, Valeriy

    2008-07-21

    State of the art soft x-ray spectroscopy techniques like Resonant Inelastic X-ray Scattering (RIXS) require diffraction gratings which can provide extremely high spectral resolution of 105-106. This problem may be addressed with a sliced multilayer grating with an ultra-high groove density (up to 50,000 mm-1) proposed in the recent publication [Voronov, D. L., Cambie, R., Feshchenko, R. M., Gullikson, E., Padmore, H. A., Vinogradov, A. V., Yashchuk, V. V., Proc. SPIE 6705, 67050E (2007)]. It has been suggested to fabricate such a grating by deposition of a soft x-ray multilayer on a substrate which is a blazed saw-tooth grating (echellette) with low groove density. Subsequent polishing applied to the coated grating removes part of the coating and forms an oblique-cut multiline structure that is a sliced multilayer grating. The resulting grating has a short-scale periodicity of lines (bilayers), which is defined by the multilayer period and the oblique-cut angle. We fabricated and tested a Sc/Si multilayer sliced grating suitable for EUV applications, which is a first prototype based on the suggested technique. In order to fabricate an echellette substrate, we used anisotropic KOH etching of a Si wafer. The etching regime was optimized to obtain smooth and flat echellette facets. A Sc/Si multilayer was deposited by dc-magnetron sputtering, and after that it was mechanically polished using a number of diamond pastes. The resulting sliced grating prototype with ~;;270 nm line period has demonstrated a dispersive ability in the 41-49 nm photon wavelength range with a diffraction efficiency of ~;;7percent for the optimized 38th order assigned to the echellette grating of 10 mu m period.

  5. Relationship Between Net Photosynthetic Rate of Cassava SC205 and Its Physio-ecological Factors

    Institute of Scientific and Technical Information of China (English)

    Yong SONG; Xuan LIN; Jinhui YANG; Yuping DENG; Xingyao XIONG

    2014-01-01

    [Objective]The aim was to measure photosynthetic characters of SC 205, a cassava cultivar, and explore the relationships of the net photosynthetic rate (Pn) with physiological and ecological factors. [Method] The diurnal variations of photosyn-thesis in leaves of SC205 were studied by LICOR-6400 portable photosynthesis system, and the relationships of the net photosynthetic rate (Pn) with physiological and ecological factors were studied by simple correlation analysis and path analysis. [Result] The curve of diurnal variation of Pn showed single peak at 10:00 am at 24.07 μ mol CO2 m2/s, without showing midday depression; the diurnal changes of stomatal conductance (Gs), transpiration rate (Tr), leaf temperature (Tl), air tempera-ture (Ta) and photosynthetic active radiation (PAR) al showed single peak curves, and there were positive relationships of Pn with Gs, Tr, Tl, Ta and PAR. The diur-nal variations of intercellular CO2 concentration (Ci), atmospheric CO2 concentration (Ca), relative humidity (RH) showed in a U-shape curve. There were highly signifi-cant positive correlation of Pn with Gs and PAR; the diurnal variation of Pn had highly significant negative correlations with Ci and Ca. The direct impact of physio-logical factors on Pn was as fol ows: Ci>Gs>Tl>Tr, and the direct impact of ecologi-cal factors was RH>PAR>Ca>Ta. [Conclusion] The research showed that Ci, Gs and Tr play very important roles in the changes of Pn among the physiological fac-tors, and PAR and Ca affect the changes of Pn among the ecological factors.

  6. The use of scFv-displaying yeast in mammalian cell surface selections.

    Science.gov (United States)

    Wang, Xin Xiang; Shusta, Eric V

    2005-09-01

    Yeast surface display has proven to be a powerful tool for the directed evolution of immunological proteins when soluble ligands are available (Cho, B.K., Kieke, M.C., Boder, E.T., Wittrup, K.D., Kranz, D.M., 1998. A yeast surface display system for the discovery of ligands that trigger cell activation. J. Immunol. Methods 220, 179; Boder, E.T., Midelfort, K.S., Wittrup, K.D., 2000. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity. Proc. Natl. Acad. Sci. U. S. A. 97, 10701; Shusta, E.V., Holler, P.D., Kieke, M.C., Kranz, D.M., Wittrup, K.D., 2000. Directed evolution of a stable scaffold for T-cell receptor engineering. Nat. Biotechnol. 18, 754; Esteban, O., Zhao, H., 2004. Directed evolution of soluble single-chain human class II MHC molecules. J. Mol. Biol. 340, 81). This investigation extends the utility of this display platform by demonstrating its capacity for use in cell panning selections. This was accomplished by employing a model single-chain antibody (scFv)-hapten system that allowed for detailed investigation of the factors governing panning success. Yeast displaying anti-fluorescein scFv (4-4-20) exhibited specific interactions with the fluoresceinated endothelial cells and could be recovered from large backgrounds of irrelevant yeast in just three rounds. Successful selections required as few as 1700 fluorescein ligands per cell, and a three-round enrichment ratio of 10(6) was possible. These results indicate that yeast surface display is a viable option for use in cell or tissue-based selections.

  7. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains

    Directory of Open Access Journals (Sweden)

    Lynch Christopher R

    2007-02-01

    Full Text Available Abstract Background Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While much recent attention has focused on smaller RNA species, larger noncoding transcripts are also thought to be highly abundant in mammalian cells. To search for large noncoding RNAs that might control gene expression or mRNA metabolism, we used Affymetrix expression arrays to identify polyadenylated RNA transcripts displaying nuclear enrichment. Results This screen identified no more than three transcripts; XIST, and two unique noncoding nuclear enriched abundant transcripts (NEAT RNAs strikingly located less than 70 kb apart on human chromosome 11: NEAT1, a noncoding RNA from the locus encoding for TncRNA, and NEAT2 (also known as MALAT-1. While the two NEAT transcripts share no significant homology with each other, each is conserved within the mammalian lineage, suggesting significant function for these noncoding RNAs. NEAT2 is extraordinarily well conserved for a noncoding RNA, more so than even XIST. Bioinformatic analyses of publicly available mouse transcriptome data support our findings from human cells as they confirm that the murine homologs of these noncoding RNAs are also nuclear enriched. RNA FISH analyses suggest that these noncoding RNAs function in mRNA metabolism as they demonstrate an intimate association of these RNA species with SC35 nuclear speckles in both human and mouse cells. These studies show that one of these transcripts, NEAT1 localizes to the periphery of such domains, whereas the neighboring transcript, NEAT2, is part of the long-sought polyadenylated component of nuclear speckles. Conclusion Our genome-wide screens in two mammalian species reveal no more than three abundant large non-coding polyadenylated RNAs in the nucleus; the canonical large noncoding RNA XIST and NEAT1 and NEAT2. The function of these noncoding RNAs in mRNA metabolism is suggested by their high levels of conservation and their intimate

  8. Human scFv antibodies (Afribumabs) against Africanized bee venom: Advances in melittin recognition.

    Science.gov (United States)

    Pessenda, Gabriela; Silva, Luciano C; Campos, Lucas B; Pacello, Elenice M; Pucca, Manuela B; Martinez, Edson Z; Barbosa, José E

    2016-03-15

    Africanized Apis mellifera bees, also known as killer bees, have an exceptional defensive instinct, characterized by mass attacks that may cause envenomation or death. From the years 2000-2013, 77,066 bee accidents occurred in Brazil. Bee venom comprises several substances, including melittin and phospholipase A2 (PLA2). Due to the lack of antivenom for bee envenomation, this study aimed to produce human monoclonal antibody fragments (single chain fragment variable; scFv), by using phage display technology. These fragments targeted melittin and PLA2, the two major components of bee venom, to minimize their toxic effects in cases of mass envenomation. Two phage antibody selections were performed using purified melittin. As the commercial melittin is contaminated with PLA2, phages specific to PLA2 were also obtained during one of the selections. Specific clones for melittin and PLA2 were selected for the production of soluble scFvs, named here Afribumabs: prefix: afrib- (from Africanized bee); stem/suffix: -umab (fully human antibody). Afribumabs 1 and 2 were tested in in vitro and in vivo assays to assess their ability to inhibit the toxic actions of purified melittin, PLA2, and crude bee venom. Afribumabs reduced hemolysis caused by purified melittin and PLA2 and by crude venom in vitro and reduced edema formation in the paws of mice and prolonged the survival of venom-injected animals in vivo. These results demonstrate that Afribumabs may contribute to the production of the first non-heterologous antivenom treatment against bee envenomation. Such a treatment may overcome some of the difficulties associated with conventional immunotherapy techniques. PMID:26829652

  9. Construction of bifunctional molecules specific to antigen and antibody’s Fc-fragment by fusion of scFv-antibodies with staphylococcal protein A

    Directory of Open Access Journals (Sweden)

    Kolibo D. V.

    2009-06-01

    Full Text Available Aim. To develop approach for detection of scFv and their complexes with antigens. Methods. The fusion proteins, which include sequences of scFv and staphylococcal protein A, were constructed and the obtained bifunctional molecules were immunochemically analysed. Results. It was shown, that scFv fused with protein A and their complexes with antigens are effectively recognized by labelled immunoglobulins with unrestricted antigenic specificity. Conclusions. The fusion of scFv with protein A fragment is a perspective approach to increase the efficiency of application in ELISA. The obtained scFv, fused with protein A, could be used for development of test-systems for the detection of diphtheria toxin.

  10. The magnesium intermetallics RE{sub 2}RuMg (RE = Sc, Y, Er, Tm, Lu). i2 superstructures of the CuAu type

    Energy Technology Data Exchange (ETDEWEB)

    Kersting, Marcel; Rodewald, Ute C.; Poettgen, Rainer [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie

    2015-06-01

    The magnesium intermetallics RE{sub 2}RuMg (RE = Sc, Y, Er, Tm, Lu) were synthesized by melting of the elements in sealed niobium ampoules followed by different annealing sequences in muffle furnaces. The samples were characterized by powder X-ray diffraction. The structure of Sc{sub 2}RuMg (Pt{sub 2}ZnCd type, P4/mmm, a = 326.07(6), c = 760.9(2) pm, wR2 = 0.0749, 138 F{sup 2} values, 9 variables) was refined from single crystal diffractometer data. Sc{sub 2}RuMg is an i2 superstructure of the CuAu type with alternating and tetragonally distorted Ru rate at Sc{sub 8} and Mg rate at Sc{sub 8} cubes.

  11. Local minima conformations of the Sc3N @C80 endohedral complex: Ab initio quantum chemical study and suggestions for experimental verification

    Science.gov (United States)

    Yanov, Ilya; Kholod, Yana; Simeon, Tomekia; Kaczmarek, Anna; Leszczynski, Jerzy

    The results of an ab initio quantum chemical study of the Sc3N@C80 endohedral complex are reported. The Hartree-Fock (HF) and B3LYP levels of theory were employed in conjunction with STO-3G and 6-31G(d) basis sets to determine the geometry and properties of the local minima conformations of Sc3N cluster inside the C80 cage. Weak bonding between the Sc3N and C80 molecule and a number of very close geometry and nearly identical by energy local minima structures can explain the large mobility of the endohedral cluster, but complicate determination of the global minimum structure. The effect of the endohedral cluster on the vibrational spectrum of Sc3N@C80 is revealed. Based on the theoretical infrared (IR) spectra, the experimental method to distinguish local minima structures of Sc3N@C80 is proposed.

  12. Structural and bonding properties of ScSi-n(n=2~6)clusters:photoelectron spectroscopy and density functional calculations

    Institute of Scientific and Technical Information of China (English)

    Xu Hong-Guang; Wu Miao-Miao; Zhang Zeng-Guang; Sun Qiang; Zheng Wei-Jun

    2011-01-01

    Anion ion photoelectron spectroscopy and density functional theory(DFT)are used to investigate the electronicand structural properties of ScSi-n(n=2~6)clusters and their neutrals. We find that the structures of ScSin are similar to those of Si-n+1. The most stable isomers of ScSin cluster anions and their neutrals are similar for n=2, 3and 5 but different for n=4 and 6, indicating that the charge effect on geometry is size dependent for small scandiumsilicon clusters. The low electron binding energy(EBE)tails observed in the spectra of ScSi-4,6 can be explained by the existence of less stable isomers. A comparison between ScSi-n and VSi-n clusters shows the effects of metal size and electron configuration on cluster geometries.

  13. Piezoelectric non-linearity in PbSc0.5Ta0.5O3 thin films

    NARCIS (Netherlands)

    Chopra, A.; Kim, Y.; Alexe, M.; Hesse, D.

    2014-01-01

    Epitaxial (001)-oriented PbSc0.5Ta0.5O3 (PST) thin films were deposited by pulsed laser deposition. Local piezoelectric investigations performed by piezoelectric force microscopy show a dual slope for the piezoelectric coefficient. A piezoelectric coefficient of 3 pm/V was observed at voltages up to

  14. Microstructural and high temperature deformation characterization of Ti-45Al-3Nb-(Cr, Mn, Mo, Sc) alloy

    International Nuclear Information System (INIS)

    Research highlights: → Complex microalloying increased remarkably the high temperature strength of Ti-45Al-3Nb alloy. → Strength increase was attributed to microstructural refinement, dispersive and solution strengthening effects. → The ductility of Ti45Al3Nb was remarkably enhanced owing to improvement of inhomogeneous distribution of electron cloud. - Abstract: The effect of complex microalloying by combinative additions of Nb, Sc, Mn, Cr and Mo to the directionally solidified Ti-45Al alloys on microstructures and mechanical properties has been examined in the present study. It is shown that a respective microstructure of fully lamellar for Ti-45Al-3Nb and Ti-45Al-3Nb-0.5Sc and basket weave type for Ti-45Al-3Nb-2Cr-2Mo-1Mn-0.5Sc were observed. The high temperature strength of Ti-45Al-3Nb alloy is improved via dispersive strengthening effect of fine Ti3(Al,Sc) dispersoids and solution strengthening effect from the other alloying elements. Enhanced ductility of Ti-45Al-3Nb alloy was achieved by Cr, Mn and Mo combinative additions.

  15. 75 FR 30372 - Foreign-Trade Zone 38-Spartanburg County, SC; Application for Reorganization/Expansion under...

    Science.gov (United States)

    2010-06-01

    ... Hill Rd., Greer, and Gateway International Business Center, Brookshire Rd. and SC Hwy. 101, Greer; Site.../Expansion under Alternative Site Framework An application has been submitted to the Foreign-Trade Zones (FTZ... FR 1170, 01/12/09; correction 74 FR 3987, 01/22/09). The ASF is an option for grantees for...

  16. Effects of trace elements at the Ni/ScYSZ interface in a model solid oxide fuel cell anode

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hansen, Karin Vels; Norrman, Kion;

    2008-01-01

    Two ScYSZ electrolytes with different impurity levels were evaluated by electrochemical impedance spectroscopy using a nickel point electrode setup. The nickel electrodes showed lower electrode polarization resistances on the pure electrolyte than on the impure electrolyte. Time-of-flight seconda...

  17. A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells.

    Directory of Open Access Journals (Sweden)

    Elena Bausch

    Full Text Available Microtubule inhibitors are invaluable tools in cancer chemotherapy: taxanes and vinca alkaloids have been successfully used in the clinic over the past thirty years against a broad range of tumors. However, two factors have limited the effectiveness of microtubule inhibitors: toxicity and resistance. In particular, the latter is highly unpredictable, variable from patient to patient and is believed to be the cause of treatment failure in most cases of metastatic cancers. For these reasons, there is an increasing demand for new microtubule inhibitors that can overcome resistance mechanisms and that, at the same time, have reduced side effects. Here we present a novel microtubule inhibitor, 4SC-207, which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. In summary, our results suggest that 4SC-207 may be a potential anti-cancer agent.

  18. Sc- and Si-associated ULF and HF-doppler oscillations during the great magnetic storm of february 1986

    International Nuclear Information System (INIS)

    Sc- and si-associated ionospheric Doppler velocity oscillations and geomagnetic pulsations observed during the great geomagnetic storm of February 1986 can be explained by the 'dynamo-motor' mechanism of ionospheric electric fields and by global compressional oscillations in the magnetosphere and ionosphere, respectively. (author)

  19. Sc- and Si-associated ULF and HF-doppler oscillations during the great magnetic storm of february 1986

    Energy Technology Data Exchange (ETDEWEB)

    Yumoto, K.; Watanabe, T. (Nagoya Univ., Toyokawa, Aichi (Japan). Research Inst. of Atmospherics); Takahashi, K.; Ogawa, T.

    1989-10-01

    Sc- and si-associated ionospheric Doppler velocity oscillations and geomagnetic pulsations observed during the great geomagnetic storm of February 1986 can be explained by the 'dynamo-motor' mechanism of ionospheric electric fields and by global compressional oscillations in the magnetosphere and ionosphere, respectively. (author).

  20. Pt Skin Versus Pt Skeleton Structures of Pt3Sc as Electrocatalysts for Oxygen Reduction

    DEFF Research Database (Denmark)

    Johansson, Tobias Peter; Ulrikkeholm, Elisabeth Therese; Hernandez-Fernandez, Patricia;

    2014-01-01

    . The development of new materials for this reaction is essential in order to increase the overall effeciency of the fuel cell. Herein, we study the effect of ultra high vacuum annealing on the structure and activity of polycrystalline Pt3Sc. Upon annealing in ultra high vacuum a Pt overlayer is formed...

  1. 75 FR 55613 - Dupont Teijin Films Including On-Site Leased Workers From Schenkers Logistics, Inc., Florence, SC...

    Science.gov (United States)

    2010-09-13

    ... Schenkers Logistics, Inc., Florence, South Carolina (subject firm). The Department's notice was published in the Federal Register on November 17, 2009 (74 FR 59255). Workers are engaged in employment related to... Logistics, Inc., Florence, SC; Amended Certification Regarding Eligibility To Apply for Worker...

  2. Interface interaction and wetting of Sc2O3 exposed to Cu-Al and Cu-Ti melts

    International Nuclear Information System (INIS)

    Scandia is a thermodynamically stable oxide and could be used as a structural material for a crucible in order to avoid a melt contamination. In the present study wetting experiments of Cu-Al and Cu-Ti melts on Scandia substrate were preformed at 1423 K by a sessile drop method. It was established that Al and Ti additions lead to the improved wetting and that the final contact angle decreases with increasing the additives concentration. For Al containing melts, the contact angle changes gradually with time, and a relatively thick interaction layer, which consists of Al2O3, Sc2O3, and metallic channels, was formed at the Sc2O3/Cu-Al interface. For Ti containing melts, the final contact angle is achieved already during heating, and an extremely thin layer based on a Ti-Sc-O compound was detected by AES at the Sc2O3/Cu-Ti interface. The results of a thermodynamic analysis, which takes into account the formation free energy of the oxides, involved in the systems, and the thermodynamic properties of the liquid solutions are in a good agreement with the experimental observations. (orig.)

  3. M.Sc. in Civil and Structural Engineering:3rd Semester and Master’s Thesis Ideas 2014

    OpenAIRE

    2014-01-01

    The following pages contain a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short master projects as well as regular 3rd semester projects at the M.Sc. programme in Civil and Structural Engineering.

  4. M.Sc. in Civil and Structural Engineering:3rd Semester and Master’s Thesis Ideas 2011

    OpenAIRE

    2011-01-01

    This catalogue contains a list of project ideas proposed by the scientific staff at the Department of Civil Engineering, Aalborg University, and a number of companies. Most of the project ideas in this catalogue may form the basis for long and short candidate projects as well as regular 3rd semester projects at the M.Sc. programme in Civil and Structural Engineering.

  5. Genome analysis coupled with physiological studies reveals a diverse nitrogen metabolism in Methylocystis sp. strain SC2.

    Directory of Open Access Journals (Sweden)

    Bomba Dam

    Full Text Available BACKGROUND: Methylocystis sp. strain SC2 can adapt to a wide range of methane concentrations. This is due to the presence of two isozymes of particulate methane monooxygenase exhibiting different methane oxidation kinetics. To gain insight into the underlying genetic information, its genome was sequenced and found to comprise a 3.77 Mb chromosome and two large plasmids. PRINCIPAL FINDINGS: We report important features of the strain SC2 genome. Its sequence is compared with those of seven other methanotroph genomes, comprising members of the Alphaproteobacteria, Gammaproteobacteria, and Verrucomicrobia. While the pan-genome of all eight methanotroph genomes totals 19,358 CDS, only 154 CDS are shared. The number of core genes increased with phylogenetic relatedness: 328 CDS for proteobacterial methanotrophs and 1,853 CDS for the three alphaproteobacterial Methylocystaceae members, Methylocystis sp. strain SC2 and strain Rockwell, and Methylosinus trichosporium OB3b. The comparative study was coupled with physiological experiments to verify that strain SC2 has diverse nitrogen metabolism capabilities. In correspondence to a full complement of 34 genes involved in N2 fixation, strain SC2 was found to grow with atmospheric N2 as the sole nitrogen source, preferably at low oxygen concentrations. Denitrification-mediated accumulation of 0.7 nmol (30N2/hr/mg dry weight of cells under anoxic conditions was detected by tracer analysis. N2 production is related to the activities of plasmid-borne nitric oxide and nitrous oxide reductases. CONCLUSIONS/PERSPECTIVES: Presence of a complete denitrification pathway in strain SC2, including the plasmid-encoded nosRZDFYX operon, is unique among known methanotrophs. However, the exact ecophysiological role of this pathway still needs to be elucidated. Detoxification of toxic nitrogen compounds and energy conservation under oxygen-limiting conditions are among the possible roles. Relevant features that may stimulate

  6. Low-temperature, high-stability, flexible thin-film transistors with a novel Sc x In1‑x O3 semiconductor

    Science.gov (United States)

    Song, Wei; Lan, Linfeng; Xiao, Peng; Lin, Zhenguo; Sun, Sheng; Li, Yuzhi; Song, Erlong; Gao, Peixiong; Zhang, Peng; Xu, Hua; Luo, Dongxiang; Xu, Miao; Peng, Junbiao

    2016-06-01

    Low-temperature scandium (Sc) incorporating In2O3 (Sc x In1‑x O3) thin films as oxide semiconductors were developed and investigated. And flexible thin-film transistors (TFTs) based on Sc x In1‑x O3 channel layers were fabricated on polyethylene naphthalate substrate with the highest process temperature of only 150 °C. The Sc x In1‑x O3 TFT displayed high on/off ratio of 107 with a turn-on voltage (V on) of only  ‑0.1 V, a subthreshold swing of 0.21 V dec‑1, and a mobility of 17.5 cm2 V‑1 s‑1. Furthermore, the flexible Sc x In1‑x O3 TFTs exhibit high stability under both positive bias stability and negative bias stability, which was ascribed to little change of the lattice parameter of In2O3 after incorporation with Sc (since the radius of Sc3+ is similar to that of In3+). More interestingly, the flexible Sc x In1‑x O3 TFTs exhibited relatively good stability under negative bias illumination stability compared to those of IGZO TFTs, which was ascribed to fewer oxygen vacancies due to the strong bonding strength of Sc-O. Finally, the transfer curves of the Sc x In1‑x O3 TFTs showed only a few changes under a curvature radius of larger than 20 mm.

  7. Purification and refolding of anti-T-antigen single chain antibodies (scFvs) expressed in Escherichia coli as inclusion bodies.

    Science.gov (United States)

    Yuasa, Noriyuki; Koyama, Tsubasa; Fujita-Yamaguchi, Yoko

    2014-02-01

    T-antigen (Galβ1-3GalNAcα-1-Ser/Thr) is an oncofetal antigen that is commonly expressed as a carbohydrate determinant in many adenocarcinomas. Since it is associated with tumor progression and metastasis, production of recombinant antibodies specific for T-antigen could lead to the development of cancer diagnostics and therapeutics. Previously, we isolated and characterized 11 anti-T-antigen phage clones from a phage library displaying human single-chain antibodies (scFvs) and purified one scFv protein, 1G11. More recently, we purified and characterized 1E8 scFv protein using a Drosophila S2 expression system. In the current study, four anti-T-antigen scFv genes belonging to Groups 1-4 were purified from inclusion bodies expressed in Escherichia coli cells. Inclusion bodies isolated from E. coli cells were denatured in 3.5 M Gdn-HCl. Solubilized His-tagged scFv proteins were purified using Ni(2+)-Sepharose column chromatography in the presence of 3.5 M Gdn-HCl. Purified scFv proteins were refolded according to a previously published method of step-wise dialysis. Two anti-T-antigen scFv proteins, 1E6 and 1E8 that belong to Groups 1 and 2, respectively, were produced in sufficient amounts, thus allowing further characterization of their binding activity with T-antigen. Specificity and affinity constants determined using enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR), respectively, provided evidence that both 1E8 and 1E6 scFv proteins are T-antigen specific and suggested that 1E8 scFv protein has a higher affinity for T-antigen than 1E6 scFv protein.

  8. Cross-plane thermal conductivity of (Ti,W)N/(Al,Sc)N metal/semiconductor superlattices

    Science.gov (United States)

    Saha, Bivas; Koh, Yee Rui; Comparan, Jonathan; Sadasivam, Sridhar; Schroeder, Jeremy L.; Garbrecht, Magnus; Mohammed, Amr; Birch, Jens; Fisher, Timothy; Shakouri, Ali; Sands, Timothy D.

    2016-01-01

    Reduction of cross-plane thermal conductivity and understanding of the mechanisms of heat transport in nanostructured metal/semiconductor superlattices are crucial for their potential applications in thermoelectric and thermionic energy conversion devices, thermal management systems, and thermal barrier coatings. We have developed epitaxial (Ti,W)N/(Al,Sc)N metal/semiconductor superlattices with periodicity ranging from 1 nm to 240 nm that show significantly lower thermal conductivity compared to the parent TiN/(Al,Sc)N superlattice system. The (Ti,W)N/(Al,Sc)N superlattices grow with [001] orientation on the MgO(001) substrates with well-defined coherent layers and are nominally single crystalline with low densities of extended defects. Cross-plane thermal conductivity (measured by time-domain thermoreflectance) decreases with an increase in the superlattice interface density in a manner that is consistent with incoherent phonon boundary scattering. Thermal conductivity values saturate at 1.7 W m-1K-1 for short superlattice periods possibly due to a delicate balance between long-wavelength coherent phonon modes and incoherent phonon scattering from heavy tungsten atomic sites and superlattice interfaces. First-principles density functional perturbation theory based calculations are performed to model the vibrational spectrum of the individual component materials, and transport models are used to explain the interface thermal conductance across the (Ti,W)N/(Al,Sc)N interfaces as a function of periodicity. The long-wavelength coherent phonon modes are expected to play a dominant role in the thermal transport properties of the short-period superlattices. Our analysis of the thermal transport properties of (Ti,W)N/(Al,Sc)N metal/semiconductor superlattices addresses fundamental questions about heat transport in multilayer materials.

  9. Gas-phase chemistry of Sc(CH{sub 3}){sub 2}{sup +} with alkenes: Activation of allylic C-H bonds by a d{sup 0} system and the migratory insertion of C=C bonds into Sc{sup +}-CH{sub 3} bonds

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Yongqing; Hill, Y.D.; Freiser, B.S. [Purdue Univ., West Lafayette, IN (United States)] [and others

    1992-11-04

    The gas-phase chemistry of Sc(CH{sub 3}){sub 2}{sup +} with alkenes was studied by Fourier transform mass spectrometry. The metal center on Sc(CH{sub 3}){sub 2}{sup +} is d{sup 0}, providing an opportunity to study alternative mechanisms of C-C or C-H activation other than the most common one involving oxidative addition. The elimination of H{sub 2} is observed in the reaction of Sc(CH{sub 3}){sub 2}{sup +} with ethylene, and the product ScC{sub 4}H{sub 8}{sup +} and ScC{sub 6}H{sub 10}{sup +} ions have a metal(methyl)(allyl) and metal-bisallyl structure, respectively, consistent with a proposed reaction mechanism involving the consecutive migratory insertion of ethylenes into the scandium-methyl bonds. In addition, theoretical calculations indicate that the metal(methyl)(allyl) structure is between 10 and 20 kcal/mol more stable than the metal(1-butene) isomer. Sc(CH{sub 3}){sub 2}{sup +} reacts with propene to form predominantly ScC{sub 4}H{sub 8}{sup +} by loss of CH{sub 4}, with minor amounts of ScC{sub 3}H{sub 4}{sup +} and ScC{sub 4}H{sub 6}{sup +} also observed. ScC{sub 4}H{sub 6}{sup +} is formed as either the exclusive or the predominant product ion in the reactions of Sc(CH{sub 3}){sub 2}{sup +} with butenes. Sc(CH{sub 3}){sub 2} reacts with cyclopentene to form predominantly ScC{sub 6}H{sub 8}{sup +} by losing CH{sub 4} and H{sub 2}. Isotope labeling studies with Sc(CD{sub 3}){sub 2}{sup +} and other structure studies indicate that all of the alkenes studied, with the exception of ethylene, react with Sc(CH{sub 3}){sub 2}{sup +} via a multicentered {sigma}-bond metathesis mechanism to activate allylic C-H bonds. Finally, the dehydrogenation reactions of Sc{sup +} with n-butane and neopentane were revisited, and a new mechanism is proposed for such chemistry in light of the new results from this study. 34 refs., 5 figs., 2 tabs.

  10. o199sc.m77t and o199sc.h77t: MGD77T data and header file for single-beam bathymetry for field activity O-1-99-SC in Southern California from 06/05/1999 to 06/17/1999

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise O-1-99-SC. The cruise was conducted in...

  11. o100sc.m77t and o100sc.h77t: MGD77T data and header file for single-beam bathymetry for field activity O-1-00-SC in San Pedro Bay, Santa Monica, California from 04/09/2000 to 04/14/2000

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise O-1-00-SC. The cruise was conducted in San...

  12. a298sc.m77t and a298sc.h77t: MGD77T data and header file for single-beam bathymetry for field activity A-2-98-SC in Santa Monica Bay from 08/23/1998 to 08/31/1998

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise A-2-98-SC. The cruise was conducted in Santa...

  13. p192sc.m77t and p192sc.h77t: MGD77T data and header files for single-beam bathymetry data for field activity P-1-92-SC in Santa Monica Basin, Southern California from 01/30/1992 to 02/04/1992

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with Loran-C and GPS navigation data was collected as part of the U.S. Geological Survey cruise P-1-92-SC. The cruise was...

  14. f389sc.m77t and f389sc.h77t: MGD77T data and header files for single-beam bathymetry data for field activity F-3-89-SC in Monterey Bay, California from 02/02/1989 to 02/15/1989

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with Loran-C RHO-RHO and GPS navigation data was collected as part of the U.S. Geological Survey cruise F-3-89-SC. The cruise was...

  15. f392sc.m77t and f392sc.h77t: MGD77T data and header files for single-beam bathymetry data for field activity F-3-92-SC in in Southern California from 04/22/1992 to 05/15/1992

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise F-3-92-SC. The cruise was conducted in...

  16. f690sc.m77t and f690sc.h77t: MGD77T data and header files for single-beam bathymetry data for field activity F-6-90-SC in Southern California, Monterey Canyon from 06/19/1990 to 07/12/1990

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with Loran-C RHO-RHO and GPS navigation data was collected as part of the U.S. Geological Survey cruise F-6-90-SC. The cruise was...

  17. a100sc.m77t and a100sc.h77t: MGD77T data and header files for single-beam bathymetry data for field activity A-1-00-SC in Southern California from Port Hueneme to Mexican Border from 06/05/2000 to 06/29/2000

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise A-1-00-SC. The cruise was conducted from Port...

  18. Adjuvant and immunostimulatory effects of a D-galactose-binding lectin from Synadenium carinatum latex (ScLL in the mouse model of vaccination against neosporosis

    Directory of Open Access Journals (Sweden)

    Cardoso Mariana R D

    2012-10-01

    Full Text Available Abstract Vaccination is an important control measure for neosporosis that is caused by a coccidian parasite, Neospora caninum, leading to abortion and reproductive disorders in cattle and serious economic impacts worldwide. A D-galactose-binding lectin from Synadenium carinatum latex (ScLL was recently described by our group with potential immunostimulatory and adjuvant effects in the leishmaniasis model. In this study, we evaluated the adjuvant effect of ScLL in immunization of mice against neosporosis. First, we investigated in vitro cytokine production by dendritic cells stimulated with Neospora lysate antigen (NLA, ScLL or both. Each treatment induced TNF-α, IL-6, IL-10 and IL-12 production in a dose-dependent manner, with synergistic effect of NLA plus ScLL. Next, four groups of C57BL/6 mice were immunized with NLA + ScLL, NLA, ScLL or PBS. The kinetics of antibody response showed a predominance of IgG and IgG1 for NLA + ScLL group, whereas IgG2a response was similar between NLA + ScLL and NLA groups. Ex vivo cytokine production by mouse spleen cells showed the highest IFN-γ/IL-10 ratio in the presence of NLA stimulation for mice immunized with NLA + ScLL and the lowest for those immunized with ScLL alone. After parasite challenge, mice immunized with NLA + ScLL or ScLL alone presented higher survival rates (70-80% and lower brain parasite burden as compared to PBS group, but with no significant changes in morbidity and inflammation scores. In conclusion, ScLL combined with NLA was able to change the cytokine profile induced by the antigen or lectin alone for a Th1-biased immune response, resulting in high protection of mice challenged with the parasite, but with low degree of inflammation. Both features may be important to prevent congenital neosporosis, since protection and low inflammatory response are necessary events to guide towards a successful pregnancy.

  19. ALERTES-SC3: an EEWS prototype for south Iberia peninsula.

    Science.gov (United States)

    Pazos, Antonio; Lopez de Mesa, Mireya; Martín Davila, José; Gallego Carrasco, Javier; Rioja del Rio, Carlos; Morgado, Arturo; Hanka, Winfried; Strollo, Angelo; Cibeira, Angel; Cabieces, Roberto; Carranza, Marta

    2016-04-01

    Since several decades Earthquake Early Warning Systems (EEWS) have been developed for different parts of the world based on the hypothesis of the earthquake characteristics can be derived from the analysis of the low energy P-wave prior to the arrival of more energetic S-waves and later phases. Thereby a time ("lead time") is available to evaluate a warning and perform automatic or semi -automatic actions on certain systems and deliver and alert to the authorities involved in emergency. The South Iberia peninsula area, between SW San Vicente Cape to the East of the Alboran sea, is one of the most seismically active zones in the Ibero-Maghrebian region, with predominantly moderate and superficial seismicity, but also big events with associated tsunamis are well documented in the area, like the 1755 Lisbon earthquake. The main goal of the ALERT-ES (2011-2013) and ALERTES-RIM (2014-2016) Spanish projects has been to develop an EEWS for South Iberia region (ALERTES-SC3 EEWS) from a regional and also an on-site approach, and the study of the scaling laws for this area to estimate the moment magnitude (Mw) and predict the expected PGV (peak ground velocity) and Pd (peak displacement) among other parameters. The ALERTES-SC3 EEWS, regional approach, prototype has been developed at the Royal Spanish Navy Observatory (ROA) and is being tested in near real time for South Iberia area. This prototype, based on the SeisComP3 software package, is largely based on algorithms derived from the analysis of the first seconds of the P wave records. Calculation of several parameters are carried out, mainly the characteristic period (τc), Peak displacement and velocity (Pd, Pv) and maximum period (τPmáx), among others, from which correlations with corresponding earthquake magnitude, peak ground velocities , etc. are derived. Decision tables have been developed in order to deliver warnings (Buforn et al, 2012). The algorithms have been implemented by ROA in the seismic data system Seis

  20. Genetic and physical fine-mapping of the Sc locus conferring indica-japonica hybrid sterility in rice (Oryza sativa L.)

    Institute of Scientific and Technical Information of China (English)

    YANG Cunyi; CHEN Zhongzheng; ZHUANG Chuxiong; MEI Mantong; LIU Yaoguang

    2004-01-01

    Hybrid sterility is a major hindrance to utilizing the heterosis in indica-japonica hybrids. To isolate a gene Sc conferring the hybrid sterility, the locus was mapped using molecular markers and an F2 population derived from a cross between near isogenic lines. A primary linkage analysis showed that Sc was linked closely with 4 markers on chromosome 3, on which the genetic distance between a marker RG227 and Sc was 0.07 cM. Chromosome walking with a rice TAC genomic library was carried out using RG227 as a starting probe, and a contig of ca. 320 kb covering the Sc locus was constructed. Two TAC clones, M45E14 and M90J01 that might cover the Sc locus, were partially sequenced. By searching the rice sequence databases with sequences of the TACs and RG227 a japonica rice BAC sequence, OSJNBb0078P24 was identified. By comparing the TAC and BAC sequences, six new PCR-based markers were developed. With these markers the Sc locus was further mapped to a region of 46 kb. The results suggest that the BAC OSJNBb0078P24 and TAC M45E14 contain the Sc gene. Six ORFs were predicted in the focused 46-kb region.

  1. Generation and Characterization of C305, a Murine Neutralizing scFv Antibody That Can Inhibit BLyS Binding to Its Receptor BCMA

    Institute of Scientific and Technical Information of China (English)

    Mei-Yun LIU; Wei HAN; Yan-Li DING; Tian-Hong ZHOU; Rui-Yang TIAN; Sheng-Li YANG; Hui LIU; Yi GONG

    2005-01-01

    B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) family and a key regulator of B cell response. Neutralizing single-chain fragment variable (scFv) antibody against BLyS binding to its receptor BCMA has the potential to play a prominent role in autoimmune disease therapy. A phage display scFv library constructed on pIII protein of M13 filamentous phage was screened using BLyS.After five rounds of panning, their binding activity was characterized by phage-ELISA. Nucleotide sequencing revealed that at least two different scFv gene fragments (C305 and D416) were obtained. The two different scFv gene fragments were expressed to obtain the soluble scFv antibodies, then the soluble scFv antibodies were characterized by means of competitive ELISA and in vitro neutralization assay. The results indicated that C305 is the neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA.

  2. DESIGN OF ANTI-CD3 ScFv-B7.1 FUSION MOLECULE AND PREDICTION OF ITS BIOLOGICAL CHARACTERISTICS

    Institute of Scientific and Technical Information of China (English)

    杨章民; 司履生; 王一理; 来宝长

    2002-01-01

    Objective To design and construct the eukaryotic expression vector which expresses Anti-CD3 ScFv-B7.1 fusion molecules and predict the biological characteristics, the rationality and feasibility of the spacer. Methods To analyze the flexibility, Hoop & Woods hydrophilicity and the epitope of Anti-CD3 ScFv-B7.1 fusion molecule at secondary structure level by computer simulation utilizing the GoldKey software. Results By comparing with Anti-CD3 ScFv and B7.1 respectively, it shows that Anti-CD3 ScFv-B7.1 fusion molecules can form correct secondary structure with the linking of the spacer, the fusion does not change the original hydrophilicity and epitopes of both Anti-CD3 ScFv and B7.1, no new epitopes emerge; The spacer is flexible and shows low antigenicity. Conclusion The design of Anti-CD3 ScFv-B7.1 fusion molecule are rational and feasible, the expressed fusion protein could retain the maximum biological activity and the function of both Anti-CD3 ScFv and B7.1.

  3. Protease-sensitive prion species in neoplastic spleens of prion-infected mice with uncoupling of PrP(Sc) and prion infectivity.

    Science.gov (United States)

    Krasemann, Susanne; Neumann, Melanie; Szalay, Beata; Stocking, Carol; Glatzel, Markus

    2013-02-01

    Prion diseases are fatal neurodegenerative disorders. An important step in disease pathophysiology is the conversion of cellular prion protein (PrP(C)) to disease-associated misfolded conformers (PrP(Sc)). These misfolded PrP variants are a common component of prion infectivity and are detectable in diseased brain and lymphoreticular organs such as spleen. In the latter, PrP(Sc) is thought to replicate mainly in follicular dendritic cells within spleen follicles. Although the presence of PrP(Sc) is a hallmark for prion disease and serves as a main diagnostic criterion, in certain instances the amount of PrP(Sc) does not correlate well with neurotoxicity or prion infectivity. Therefore, it has been proposed that prions might be a mixture of different conformers and aggregates with differing properties. This study investigated the impact of disruption of spleen architecture by neoplasia on the abundance of different PrP species in spleens of prion-infected mice. Although follicular integrity was completely disturbed, titres of prion infectivity in neoplastic spleens were not significantly altered, yet no protease-resistant PrP(Sc) was detectable. Instead, unique protease-sensitive prion species could be detected in neoplastic spleens. These results indicate the dissociation of PrP(Sc) and prion infectivity and showed the presence of non-PrP(Sc) PrP species in spleen with divergent biochemical properties that become apparent after tissue architecture disruption. PMID:23136363

  4. Steel-plate composite (SC) walls for safety related nuclear facilities: Design for in-plane forces and out-of-plane moments

    Energy Technology Data Exchange (ETDEWEB)

    Varma, Amit H., E-mail: ahvarma@purdue.edu [Bowen Laboratory, School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Malushte, Sanjeev R., E-mail: smalusht@bechtel.com [Bechtel Power Corporation, Frederick, MD (United States); Sener, Kadir C., E-mail: ksener@purdue.edu [Bowen Laboratory, School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Lai, Zhichao, E-mail: laiz@purdue.edu [Bowen Laboratory, School of Civil Engineering, Purdue University, West Lafayette, IN (United States)

    2014-04-01

    Steel-concrete (SC) composite walls being considered and used as an alternative to conventional reinforced concrete (RC) walls in safety-related nuclear facilities due to their construction economy and structural efficiency. However, there is a lack of standardized codes for SC structures, and design guidelines and approaches are still being developed. This paper presents the development and verification of: (a) mechanics based model, and (b) detailed nonlinear finite element model for predicting the behavior and failure of SC wall panels subjected to combinations of in-plane forces. The models are verified using existing test results, and the verified models are used to explore the behavior of SC walls subjected to combinations of in-plane forces and moments. The results from these investigations are used to develop an interaction surface in principle force (S{sub p1}–S{sub p2}) space that can be used to design or check the adequacy of SC wall panels. The interaction surface is easy to develop since it consists of straight line segments connecting anchor points defined by the SC wall section strengths in axial tension, in-plane shear, and compression. Both models and the interaction surface (for design) developed in this paper are recommended for future work. However, in order to use these approaches, the SC wall section should be detailed with adequate shear connector and tie bar strength and spacing to prevent non-ductile failure modes.

  5. Cloning of scFv from hybridomas using a rational strategy: Application as a receptor to sensitive detection microcystin-LR in water.

    Science.gov (United States)

    Zhang, Xiuyuan; He, Kuo; Zhao, Ruiping; Wang, Lixia; Jin, Yandan

    2016-10-01

    Single chain variable fragment (scFv), containing of heavy and light chains (VH and VL) joined by a short peptide linker, has been used widely for immunodetection. Nevertheless, cloning functional variable genes is still a bottle neck for the scFv generation technology. Here, a rational strategy for cloning and selecting variable region genes from an anti-microcystin-LR hybridoma was devised, then the functional VH and VL genes were recloned and assembled to scFv using splicing overlap extension PCR. The resulting scFv gene was recombinantly expressed as a soluble scFv-alkaline phosphatase fusion protein (scFv-AP) by vector PLIP6/GN. Then an indirect competitive chemiluminescent enzyme immunoassay (ic-CLEIA) for detection of microcystin-LR was developed. The half-maximum inhibition concentrations (IC50) and limits of detection (LODs, IC15) were 0.81 ± 0.04 μgL(-1) and 0.13 ± 0.03 μgL(-1), respectively. With the mean coefficient of variation lowing 8%, the mean recovery in intra-assay and inter-assay were 100.06% and 96.46%, The proposed strategy should be useful for generation scFv in a rapid and simple way. PMID:27380224

  6. SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies

    International Nuclear Information System (INIS)

    Introduction: Amyloid deposits are associated with a broad spectrum of disorders including monoclonal gammopathies, chronic inflammation, and Alzheimer's disease. In all cases, the amyloid pathology contains, in addition to protein fibrils, a plethora of associated molecules, including high concentrations of heparan sulfate proteoglycans (HSPGs). Methods: We have evaluated radioiodinated scFvs that bind HS for their ability to image amyloid deposits in vivo. scFv's with different binding characteristics were isolated by phage display using HS extracted from bovine kidney or mouse and human skeletal muscle glycosaminoglycans (GAGs). Following purification and radioiodination, the biodistribution of 125I-scFv's was assessed in mice with inflammation-associated AA amyloidosis or in amyloid-free mice by using SPECT imaging, biodistribution measurements and tissue autoradiography. Results: Four different scFv's all showed binding in vivo to amyloid in the spleen, liver and kidney of diseased mice; however, three of the scFv's also bound to sites within these organs in disease free mice. One scFv specific for hypersulfated HSPGs preferentially bound amyloid and did not accumulate in healthy tissues. Conclusions: These data indicate that HS expressed in amyloid deposits has unique qualities that can be distinguished from HS in normal tissues. A scFv specific for rare hypersulfated HS was used to selectively image AA amyloid in mice with minimal retention in normal tissue.

  7. Effect of Sc/Zr ratio on the microstructure and mechanical properties of new type of Al–Zn–Mg–Sc–Zr alloys

    Energy Technology Data Exchange (ETDEWEB)

    Li, Gen [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Zhao, Naiqin, E-mail: nqzhao@tju.edu.cn [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300072 (China); Liu, Tao [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Li, Jiajun; He, Chunnian; Shi, Chunsheng; Liu, Enzuo [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China); Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300072 (China); Sha, Junwei [School of Materials Science and Engineering, Tianjin University, Tianjin 300072 (China)

    2014-11-03

    The rare earth scandium (Sc) as a microalloying element has attracted an increasing interest in aluminum alloys for achieving excellent mechanical properties. Combining with zirconium, high strength and low price Al–Sc alloys are expected. The effects of Sc and Zr on the grain refinement, recrystallization resistance and precipitation hardening were investigated in new type of Al–Zn–Mg–Sc–Zr alloys by rolling, annealing and aging processes. Scandium addition into the Al–Zn–Mg alloys can efficiently refine the grain size and increase recrystallization resistance, especially together with zirconium addition. The maximum value of the yield-to-tensile strength (627 MPa/667 MPa) was obtained with 0.2Sc/0.4Zr ratio of the alloy after solution-aging treatment. The additional strengthening of the alloys is attributed to the grain refinement and the precipitation-strengthening effect of Al{sub 3}Sc, Al{sub 3}Zr or Al{sub 3}(Sc, Zr) in the proper ratio of Sc/Zr during aging.

  8. Cloning of scFv from hybridomas using a rational strategy: Application as a receptor to sensitive detection microcystin-LR in water.

    Science.gov (United States)

    Zhang, Xiuyuan; He, Kuo; Zhao, Ruiping; Wang, Lixia; Jin, Yandan

    2016-10-01

    Single chain variable fragment (scFv), containing of heavy and light chains (VH and VL) joined by a short peptide linker, has been used widely for immunodetection. Nevertheless, cloning functional variable genes is still a bottle neck for the scFv generation technology. Here, a rational strategy for cloning and selecting variable region genes from an anti-microcystin-LR hybridoma was devised, then the functional VH and VL genes were recloned and assembled to scFv using splicing overlap extension PCR. The resulting scFv gene was recombinantly expressed as a soluble scFv-alkaline phosphatase fusion protein (scFv-AP) by vector PLIP6/GN. Then an indirect competitive chemiluminescent enzyme immunoassay (ic-CLEIA) for detection of microcystin-LR was developed. The half-maximum inhibition concentrations (IC50) and limits of detection (LODs, IC15) were 0.81 ± 0.04 μgL(-1) and 0.13 ± 0.03 μgL(-1), respectively. With the mean coefficient of variation lowing 8%, the mean recovery in intra-assay and inter-assay were 100.06% and 96.46%, The proposed strategy should be useful for generation scFv in a rapid and simple way.

  9. Wavelengths, energy levels and hyperfine structure of Mn II and Sc II.

    Science.gov (United States)

    Nave, Gillian; Pickering, Juliet C.; Townley-Smith, Keeley I. M.; Hala, .

    2015-08-01

    For many decades, the Atomic Spectroscopy Groups at the National Institute of Standards and Technology (NIST) and Imperial College London (ICL) have measured atomic data of astronomical interest. Our spectrometers include Fourier transform (FT) spectrometers at NIST and ICL covering the region 1350 Å to 5.5 μm and a 10.7-m grating spectrometer at NIST covering wavelengths from 300 - 5000 Å. Sources for these spectra include high-current continuous and pulsed hollow cathode (HCL) lamps, Penning discharges, and sliding spark discharges. Recent work has focused on the measurement and analysis of wavelengths, energy levels, and hyperfine structure (HFS) constants for iron-group elements. The analysis of FT spectra of Cr I, Mn I, and Mn II is being led by ICL and is described in a companion poster [1]. Current work being led by NIST includes the analysis of HFS in Mn II, analysis of Mn II in the vacuum ultraviolet, and a comprehensive analysis of Sc II.Comprehensive HFS constants for Mn II are needed for the interpretation of stellar spectra and incorrect abundances may be obtained when HFS is omitted. Holt et al. [2] have measured HFS constants for 59 levels of Mn II using laser spectroscopy. We used FT spectra of Mn/Ni and Mn/Cu HCLs covering wavelength ranges from 1350 Å to 5.4 μm to confirm 26 of the A constants of Holt et al. and obtain values for roughly 40 additional levels. We aim to obtain HFS constants for the majority of lines showing significant HFS that are observed in chemically-peculiar stars.Spectra of Sc HCLs have been recorded from 1800 - 6700 Å using a vacuum ultraviolet FT spectrometer at NIST. Additional measurements to cover wavelengths above 6700 Å and below 1800 Å are in progress. The spectra are being analyzed by NIST and Alighar Muslim University, India in order to derive improved wavelengths, energy levels, and hyperfine structure parameters.This work was partially supported by NASA, the STFC and PPARC (UK), the Royal Society of the UK

  10. Cloning approach and functional analysis of anti-intimin single-chain variable fragment (scFv

    Directory of Open Access Journals (Sweden)

    Elias Waldir P

    2011-02-01

    Full Text Available Abstract Background Intimin is an important virulence factor involved in the pathogenesis of enteropathogenic Escherichia coli (EPEC and enterohemorrhagic Escherichia coli (EHEC. Both pathogens are still important causes of diarrhea in children and adults in many developing and industrialized countries. Considering the fact that antibodies are important tools in the detection of various pathogens, an anti-intimin IgG2b monoclonal antibody was previously raised in immunized mice with the conserved sequence of the intimin molecule (int388-667. In immunoblotting assays, this monoclonal antibody showed excellent specificity. Despite good performance, the monoclonal antibody failed to detect some EPEC and EHEC isolates harboring variant amino acids within the 338-667 regions of intimin molecules. Consequently, motivated by its use for diagnosis purposes, in this study we aimed to the cloning and expression of the single-chain variable fragment from this monoclonal antibody (scFv. Findings Anti-intimin hybridoma mRNA was extracted and reversely transcripted to cDNA, and the light and heavy chains of the variable fragment of the antibody were amplified using commercial primers. The amplified chains were cloned into pGEM-T Easy vector. Specific primers were designed and used in an amplification and chain linkage strategy, obtaining the scFv, which in turn was cloned into pAE vector. E. coli BL21(DE3pLys strain was transformed with pAE scFv-intimin plasmid and subjected to induction of protein expression. Anti-intimin scFv, expressed as inclusion bodies (insoluble fraction, was denatured, purified and submitted to refolding. The protein yield was 1 mg protein per 100 mL of bacterial culture. To test the functionality of the scFv, ELISA and immunofluorescence assays were performed, showing that 275 ng of scFv reacted with 2 mg of purified intimin, resulting in an absorbance of 0.75 at 492 nm. The immunofluorescence assay showed a strong reactivity with

  11. Structural, electronic, optical and thermodynamic properties of cubic REGa{sub 3} (RE = Sc or Lu) compounds: Ab initio study

    Energy Technology Data Exchange (ETDEWEB)

    Murtaza, G., E-mail: murtaza@icp.edu.pk [Materials Modeling Laboratory, Department of Physics, Islamia College Peshawar (Pakistan); Gupta, S.K. [Department of Physics, Michigan Technological University, Houghton, MI 49931 (United States); Seddik, T. [Laboratoire de Physique Quantique et de Modélisation Mathématique, Université de Mascara, 29000 Mascara (Algeria); Khenata, R., E-mail: khenata_rabah@yahoo.fr [Laboratoire de Physique Quantique et de Modélisation Mathématique, Université de Mascara, 29000 Mascara (Algeria); Alahmed, Z.A. [Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia); Ahmed, R. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, UTM Skudai, 81310 Johor (Malaysia); Khachai, H. [Physics Department, Djillali Liabes University of Sidi Bel-Abbes (Algeria); Jha, P.K. [Department of Physics, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364001 (India); Bin Omran, S. [Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia)

    2014-06-01

    Highlights: • REGa{sub 3} (RE = Sc or Lu) compounds are mechanical stabile. • Both ScGa{sub 3} and LuGa{sub 3} exhibit metallic behavior just like other REGa{sub 3} compounds. • Melting temperature T{sub m} (K) for ScGa{sub 3} and LuGa{sub 3} are 1244.2 and 1143.8. • High absorption observed in the visible energy region. • The present study would be helpful for future experimental/theoretical explorations. - Abstract: Structural, elastic, optoelectronic and thermodynamic properties of REGa{sub 3} (RE = Sc and Lu) compounds have been studied self consistently by employing state of the art full potential (FP) linearized (L) approach of augmented plane wave (APW) plus local orbitals method. Calculations were executed at the level of Perdew–Burke and Ernzerhof (PBE) parameterized generalized gradient approximation (GGA) for exchange correlation functional in addition to modified Becke–Johnson (mBJ) potential. Our obtained results of lattice parameters show reasonable agreement to the previously reported experimental and other theoretical studies. Analysis of the calculated band structure of ScGa{sub 3} and LuGa{sub 3} compounds demonstrates their metallic character. Moreover, a positive value of calculated Cauchy pressure, in addition to reflecting their ductile nature, endorses their metallic character as well. To understand optical behavior calculations related to the important optical parameters; real and imaginary parts of the dielectric function, reflectivity R(ω), refractive index n(ω) and electron energy-loss function L(ω) have also been performed. In the present work, thermodynamically properties are also investigated by employing lattice vibrations integrated in quasi harmonic Debye model. Obtained results of volume, heat capacity and Debye temperature as a function of temperature for both compounds, at different values of pressure, are found to be consistent. The calculated value of melting temperature for both compounds (ScGa{sub 3} and Lu

  12. Anomalous ionic conductivity of Sc sub 2 (WO sub 4) sub 3 mediated by structural changes at high pressures and temperatures

    CERN Document Server

    Secco, R A; Imanaka, N; Adachi, G

    2002-01-01

    The ionic conductivity of Sc sub 2 (WO sub 4) sub 3 at 400 deg. C shows a normal decrease with increase in pressure up to 2.9 GPa but then increases anomalously at pressures up to 4.3 GPa. Synchrotron in situ x-ray diffraction results show that Sc sub 2 (WO sub 4) sub 3 undergoes pressure-induced amorphization at pressures coincident with the reversal in conductivity behaviour. The loss of crystal structure at high pressure may be associated with the property of negative thermal expansion in Sc sub 2 (WO sub 4) sub 3.

  13. Structure and Physical properties of New layered oxypnictides $Sr_4Sc_2O_6M_2As_2$ (M=Fe and Co)

    OpenAIRE

    Xie, Y. L.; Liu, R. H.; Wu, T; G Wu; Song, Y. A.; Tan, D; Wang, X F; Chen, H.; Ying, J. J.; Y. J. Yan; Li, Q. J.; Chen, X. H.

    2009-01-01

    We have successfully prepared the new layered oxypnictides $Sr_4Sc_2O_6M_2As_2$ (M=Fe and Co). They adopt the tetragonal structure, being the same as that of $Sr_4Sc_2O_6Fe_2P_2$. The lattice constants are a=0.4045 nm and c= 0.5802 nm for M=Fe, and a=0.4045 nm and c=1.5695 nm for M=Co, respectively. Their transport and magnetic properties have been systematically studied. The temperature dependence of Hall coefficient and thermoelectric powder for $Sr_4Sc_2O_6Fe_2As_2$ compound show complicat...

  14. Direct mass measurements of neutron-rich $^{86}$Kr projectile fragments and the persistence of neutron magic number $N$ = 32 in Sc isotopes

    OpenAIRE

    Xu, Xing; Wang, Meng; Zhang, Yu-Hu; Xu, Hu-Shan; Shuai, Peng; Tu, Xiao-Lin; Litvinov, Yuri A.; Zhou, Xiao-Hong; Sun, Bao-hua; Yuan, You-Jin; Xia, Jia-wen; Yang, Jian-Cheng; Blaum, Klaus; Chen, Rui-jiu; Chen, Xiang-cheng

    2016-01-01

    In this paper, we present direct mass measurements of neutron-rich $^{86}$Kr projectile fragments conducted at the HIRFL-CSR facility in Lanzhou by employing the Isochronous Mass Spectrometry (IMS) method. The new mass excesses of $^{52-54}$Sc nuclides are determined to be -40492(82), -38928(114), -34654(540) keV, which show a significant increase of binding energy compared to the reported ones in the Atomic Mass Evaluation 2012 (AME12). In particular, $^{53}$Sc and $^{54}$Sc are more bound b...

  15. 化学杀雄剂SC2053对瓜叶菊杀雄效果的初步研究%The Chemical Male Sterile Effect of SC2053 on Cineraria (Senecio cruentus DC.)

    Institute of Scientific and Technical Information of China (English)

    孙兆法; 翟晓灵; 王瑞英; 丁世民; 陈莉

    2005-01-01

    瓜叶菊(Senecio eruentus DC.)为头状花序,小花聚生,生产杂交种子时人工去雄难度很大。化学杀雄剂SC2053对多种作物有效,但是对瓜叶菊的杀雄效果如何尚未见报道。

  16. Prevalência de hiperidrose em uma amostra populacional de Blumenau - SC, Brasil Prevalence of hyperhidrosis in the adult population of Blumenau-SC, Brazil

    Directory of Open Access Journals (Sweden)

    Romero Felini

    2009-08-01

    Full Text Available FUNDAMENTOS: A hiperidrose é um distúrbio pouco conhecido, caracterizado pela produção excessiva de suor. Manifesta-se sob várias formas, afetando áreas como axilas, mãos, pés e face. Seus sintomas trazem prejuízos para o paciente, desde limitações no trabalho até constrangimento social e transtornos psicológicos. OBJETIVOS: O objetivo deste trabalho é estimar a prevalência de hiperidrose na cidade de Blumenau. MÉTODOS: A pesquisa foi realizada entre 21 de agosto e 1o de setembro de 2006, nos terminais urbanos de Blumenau: SC, entrevistando-se 500 pessoas abordadas de forma aleatória. RESULTADOS: Dentre os entrevistados, 45 deles, que correspondem a 9% do total, preencheram os requisitos mínimos para serem classificados como portadores de hiperidrose. A faixa etária mais acometida foi entre 18 e 30 anos (11,8%. O número de portadores de hiperidrose do sexo masculino foi maior em números tanto absolutos quanto relativos. A característica mais prevalente foi frequência de hiperidrose ao menos uma vez por semana, encontrada em 91,11% dos afetados; a menos prevalente foi cessação de suor durante o sono, presente em 37,77%. CONCLUSÕES: Observa-se que a prevalência de hiperidrose em Blumenau é maior que a encontrada em outras pesquisas semelhantes, não evidenciando raridade na presente amostra.BACKGROUND: Hyperhidrosis is a little known disorder, characterized by excessive production of sweat. Hyperhidrosis may occur under several circumstances and appears in body parts like armpits, hands, feet, and face, consequently causing problems to the patient like job limitation, social embarrassment, and psychological damage. OBJECTIVES: Using these theoretical views as a starting point, the study aimed to evaluate the prevalence of hyperhidrosis in Blumenau. METHODOLOGY: Utilizing interviews, the research was conducted with 500 subjects randomly approached, in the period ranging from August 21 to September 1st, 2006. RESULTS: 45

  17. Electronic structure and bonding in garnet crystals Gd3Sc2Ga3O12, Gd3Sc2Al3O12, and Gd3Ga3O12 compared to Y3Al3O12

    Science.gov (United States)

    Xu, Yong-Nian; Ching, W. Y.; Brickeen, B. K.

    2000-01-01

    The electronic structure and bonding of Gd3Sc2Ga3O12 (GSGG), Gd3Sc2Al3O12 (GSAG), and Gd3Ga5O12 (GGG) crystals with a garnet structure are studied by means of first-principles local-density calculations. The results are compared with a similar calculation on yttrium aluminum garnet [Y3Al5O12 (YAG)]. The calculated equilibrium volumes of the three crystals are close to the measured volumes with a slight overestimation for GGG. GGG also has a smaller bulk modulus than the other three crystals. The calculated density of states and their atomic and orbital decompositions are presented and contrasted. All four crystals show very similar band structures and interatomic bonding. However, it is found that in GSGG and GSAG crystals, the Sc atom at the octahedral site shows a higher covalent character and an increased bond order in comparison to Ga or Al at the same site. This result may provide some insight into the significant difference in the radiation hardness of Cr3+:Nd3+:GSGG as compared to Nd3+:YAG.

  18. Electronic structure and bonding in garnet crystals Gd3Sc2Ga3O12, Gd3Sc2Al3O12, and Gd3Ga3O12 compared to Y3Al3O12

    International Nuclear Information System (INIS)

    The electronic structure and bonding of Gd3Sc2Ga3O12 (GSGG), Gd3Sc2Al3O12 (GSAG), and Gd3Ga5O12 (GGG) crystals with a garnet structure are studied by means of first-principles local-density calculations. The results are compared with a similar calculation on yttrium aluminum garnet [Y3Al5O12 (YAG)]. The calculated equilibrium volumes of the three crystals are close to the measured volumes with a slight overestimation for GGG. GGG also has a smaller bulk modulus than the other three crystals. The calculated density of states and their atomic and orbital decompositions are presented and contrasted. All four crystals show very similar band structures and interatomic bonding. However, it is found that in GSGG and GSAG crystals, the Sc atom at the octahedral site shows a higher covalent character and an increased bond order in comparison to Ga or Al at the same site. This result may provide some insight into the significant difference in the radiation hardness of Cr3+:Nd3+:GSGG as compared to Nd3+:YAG. (c) 2000 The American Physical Society

  19. Phase separation in Al-Zr-Sc alloys: from atomic jumps to ordered precipitates growth; Separation de phase dans les alliages Al-Zr-Sc: du saut des atomes a la croissance de precipites ordonnes

    Energy Technology Data Exchange (ETDEWEB)

    Clouet, E

    2004-07-01

    Zirconium and scandium addition to aluminium alloys leads to the formation of ordered precipitates. This study aims to a better understanding of precipitation kinetics thanks to an approach combining atomic and mesoscopic models. An experimental work has been undertaken too so as to characterize by transmission electron microscopy Al{sub 3}Zr kinetics of precipitation. We mainly focus on the nucleation stage and, in this purpose, an atomic model lying on a rigid lattice has been built for Al-Zr-Sc system allowing us to study precipitation with kinetic Monte Carlo simulations. While keeping the vacancy exchange mechanism for diffusion, we introduce multi-site interactions going thus beyond a simple pair interaction model, and test the influence of these interactions on kinetics of precipitation. The comparison between Monte Carlo simulations and classical nucleation theory shows that mesoscopic models can lead to a good description of the nucleation stage of Al{sub 3}Zr and Al{sub 3}Sc as long as the order tendency of the system has been taken into account to calculate input parameters of these models. For the ternary Al-Zr-Sc system, atomic simulations allow a better understanding of the precipitation kinetic path. It is then possible to extend the field of classical nucleation theory so as to model nucleation in a ternary alloy where the stoichiometry of the precipitates is unknown. (author)

  20. Leadership in nursing: An experience of hospital nurses in the south of Santa Catarina/SC.

    Directory of Open Access Journals (Sweden)

    Dalila Felipe Bitencourt

    2013-01-01

    Full Text Available Qualitative research using the case study, it’s order to understand the vision of nurses in a hospital in the southern of Santa Catarina/SC about their experience as leaders of nursing team. Participants were ten nurses working in this role. Data collection was performed in the hospital, between the months of May and June 2012, using the technique of semi-structured interview, based on the guiding question of the study. The analysis of data was performed qualitative and comprised the organization, classification and final analysis. The results show that most nurses do not feel prepared to exercise a leading role, which derives, in most cases, the lack of academic preparation, institutional issues and the reasons inherent in early stage, especially insecurity. The professionals working in other categories of nursing at the same institution need to learn to position themselves against the new post, especially in dealing with colleagues who are now under his leadership. While most have expressed difficulties in the process of transition between academia and professional life were identified that professionals are clear about the roles, skills and abilities necessary for leadership. It is also noted that nurses feel that in some situations they cannot exercise their leadership in the way they consider most appropriate.