WorldWideScience

Sample records for cell technology standards

  1. The developments of international hydrogen and fuel cell technology standards and the response strategies in Taiwan

    International Nuclear Information System (INIS)

    Tso, C.

    2009-01-01

    The application of hydrogen and fuel cells has expanded as the technology in international markets has improved. Leading countries have focused on establishing hydrogen and fuel cell technology standards. Both the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC) continuously release new hydrogen and fuel cell related standards. Although the government of Taiwan is promoting the development of a hydrogen and fuel cell industry, it may delay the commercialized schedule if there are no hydrogen and fuel cell related standards and regulations in place. Standards and regulations must be established as quickly as possible in order to accelerate the progress of the hydrogen and fuel cell industry. This presentation reviewed the international progress in hydrogen and fuel cell development and explained Taiwan's response strategies regarding the adoption of hydrogen and fuel cell products in niche Taiwanese markets

  2. Automotive Technology Skill Standards

    Science.gov (United States)

    Garrett, Tom; Asay, Don; Evans, Richard; Barbie, Bill; Herdener, John; Teague, Todd; Allen, Scott; Benshoof, James

    2009-01-01

    The standards in this document are for Automotive Technology programs and are designed to clearly state what the student should know and be able to do upon completion of an advanced high-school automotive program. Minimally, the student will complete a three-year program to achieve all standards. Although these exit-level standards are designed…

  3. ISO standardization in nuclear technology

    Energy Technology Data Exchange (ETDEWEB)

    Brabec, D [Ustav pro Vyzkum, Vyrobu a Vyuziti Radioisotopu, Prague (Czechoslovakia); Cermak, O [Urad pro Normalizaci a Mereni, Prague (Czechoslovakia)

    1984-10-01

    The activity is described of the technical commission ISO/TC 85 which is currently divided into 4 subcommissions (SC) and 24 working groups. SC 1 ''Terminology, definitions, units, abbreviations'' has one working group. The most important document of this SC is ISO 921-1972 (Dictionary of nuclear technology). SC 2 ''Radiation protection'' has 9 working groups and has processed standards in dosimetry. SC 3 ''Technology of power reactors'' has 6 working groups and its work is related to IAEA activities within the NUSS program. SC 4 ''Technology of nuclear fuels'' has 8 working groups. SC 4 has compiled the basic standards for sealed sources and methods of testing their tightness. The results of the work of this group have been reflected into the standardization work of CMEA. A list is given of published international standards within TC 85.

  4. Importance of international standards on hydrogen technologies

    International Nuclear Information System (INIS)

    Bose, T.K.; Gingras, S.

    2001-01-01

    This presentation provided some basic information regarding standards and the International Organization for Standardization (ISO). It also explained the importance of standardization activities, particularly ISO/TC 197 which applies to hydrogen technologies. Standards are established by consensus. They define the minimum requirements that will ensure that products and services are reliable and effective. Standards contribute to the elimination of technical barriers to trade (TBT). The harmonization of standards around the world is desirable in a free trade environment. The influence of the TBT on international standardization was discussed with particular reference to the objectives of ISO/TC 197 hydrogen technologies. One of the priorities for ISO/TC 197 is a hydrogen fuel infrastructure which includes refuelling stations, fuelling connectors, and storage technologies for gaseous and liquid hydrogen. Other priorities include an agreement between the International Electrotechnical Commission (IEC) and the ISO, in particular the IEC/TC 105 and ISO/TC 197 for the development of fuel cell standards. The international standards that have been published thus far include ISO 13984:1999 for liquid hydrogen, land vehicle fuelling system interface, and ISO 14687:1999 for hydrogen fuel product specification. Standards are currently under development for: liquid hydrogen; airport hydrogen fuelling facilities; gaseous hydrogen blends; basic considerations for the safety of hydrogen systems; gaseous hydrogen and hydrogen blends; and gaseous hydrogen for land vehicle filling connectors. It was concluded that the widespread use of hydrogen is dependent on international standardization

  5. ISO standardization in nuclear technology

    Energy Technology Data Exchange (ETDEWEB)

    Brabec, D. (Ustav pro Vyzkum, Vyrobu a Vyuziti Radioisotopu, Prague (Czechoslovakia)); Cermak, O. (Urad pro Normalizaci a Mereni, Prague (Czechoslovakia))

    1984-10-01

    The activity is described of the technical commission ISO/TC 85 which is currently divided into 4 subcommissions (SC) and 24 working groups. SC 1 ''Terminology, definitions, units, abbreviations'' has one working group. The most important document of this SC is ISO 921-1972 (Dictionary of nuclear technology). SC 2 ''Radiation protection'' has 9 working groups and has processed standards in dosimetry. SC 3 ''Technology of power reactors'' has 6 working groups and its work is related to IAEA activities within the NUSS program. SC 4 ''Technology of nuclear fuels'' has 8 working groups. SC 4 has compiled the basic standards for sealed sources and methods of testing their tightness. The results of the work of this group have been reflected into the standardization work of CMEA. A list is given of published international standards within TC 85.

  6. Fulfilling a Promise: Standards for Technological Literacy.

    Science.gov (United States)

    Bybee, Rodger W.

    2003-01-01

    Discusses the place of standards in U.S. education, the development of the Standards for Technological Literacy, and the recent publication of "Advancing Excellence in Technological Literacy: Student Assessment, Professional Development, and Program Standards." (Contains 21 references.) (SK)

  7. Biofuels: policies, standards and technologies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-09-15

    Skyrocketing prices of crude oil in the middle of the first decade of the 21st century accompanied by rising prices for food focused political and public attention on the role of biofuels. On the one hand, biofuels were considered as a potential automotive fuel with a bright future, on the other hand, biofuels were accused of competing with food production for land. The truth must lie somewhere in-between and is strongly dependent on the individual circumstance in different countries and regions. As food and energy are closely interconnected and often compete with each other for other resources, such as water, the World Energy Council - following numerous requests of its Member Committees - decided to undertake an independent assessment of biofuels policies, technologies and standards.

  8. China's High-technology Standards Development

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    There are several major technology standards, including audio video coding (AVS), automotive electronics, third generation (3G) mobile phones, mobile television, wireless networks and digital terrestrial television broadcasting, that have been released or are currently under development in China. This article offers a detailed analysis of each standard and studies their impact on China's high-technology industry.

  9. LTE-Advanced Relay Technology and Standardization

    CERN Document Server

    Yuan, Yifei

    2013-01-01

    LTE-Advanced Relay Technology and Standardization provides a timely reference work for relay technology with the finalizing of LTE Release 10 specifications. LTE-Advanced is quickly becoming the global standard for 4G cellular communications. The relay technology, as one of the key features in LTE-Advanced, helps not only to improve the system coverage and capacity, but also to save the costs of laying wireline backhaul. As a leading researcher in the field of LTE-Advanced standards, the author provides an in-depth description of LTE-A relay technology, and explains in detail the standard specification and design principles.     Readers from both academic and industrial fields can find sections of interest to them: Sections 2 & 4 could benefit researchers in academia and those who are engaged in exploratory work, while Sections 3 & 4 are more useful to engineers. Dr. Yifei Yuan is the Technical Director at the Standards Department of ZTE Inc.

  10. Fuel-cell technology for vehicular applications; L`introduzione delle pile a combustibile nel settore dei trasporti: proposte, standard e normative per sistemi di bordo ed impianti

    Energy Technology Data Exchange (ETDEWEB)

    Ciancia, A.; Pede, G.; Marmigi, R. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dip. Energia

    1998-12-31

    The fuel-cell technology applied to engines for vehicular applications grants broad margins of convenience over any known alternative engine for what concerns the compliance with any present and foreseeable environmental and energy saving regulations. On the other hand, the use of hydrogen produced on board from fuels or stored as a liquid or a gas, raises new problems from the point of view of safety regulations and standards both in the design and use of vehicles and in the fuel production and distribution. The present work is aimed at pointing out the above main safety problems, describes the technical-choices together with their technical grounds, in the framework of the italian and U E standards and regulations. The report is then made up of three parts. The initial section where the on board storage of the fuel from technical-economical point of view is discussed. with particular reference to the compressed hydrogen, the second describing the regulations and standards holding in the field of on board pressure equipment and reporting the ongoing ENEA`s activities in the field. The final part is devoted to the distribution and supply of the fuels to the fuel cell powered electric vehicles. [Italiano] La tecnologia delle celle a combustibile, impiegata nella realizzazione dei propulsori dei veicoli elettrici, conferisce ad essi ampi margini di vantaggio su ogni altro tipo di motorizzazione per quanto riguarda le attuali e prevedibili future normative ambientali e di risparmio energetico. Il presente rapporto si propone di evidenziare alcuni tra questi problemi ed esporre e motivare le soluzioni tecniche previste nell`ambito degli specifici programmi dell`ENEA, in un contesto normativo di riferimento nazionale e comunitario. Il rapporto si compone pertanto di tre parti: una parte iniziale dove e` affrontato dal punto di vista tecnico-economico il problema del trasporto del combustibile a bordo con particolare riferimento all`idrogeno compresso, una seconda in cui

  11. Relations between the technological standards and technological appropriation

    Directory of Open Access Journals (Sweden)

    Carlos Alberto PRADO GUERRERO

    2010-06-01

    Full Text Available The objective of this study is to analyze the educational practices of using Blackboard in blended learning environments with students of higher education to understand the relationship between technological appropriation and standards of educational technology. To achieve that goal, the following research question was raised: ¿To what extent are the standards of education technology with the appropriation of technology in blended learning environments in higher educa­tion related? The contextual framework of this work includes the following topics: the institution, teaching, teachers and students. The design methodology that was used is of a correlation type. Correlations were carried out to determine the frequency and level in the technological standards as well as the appropriation of technology. In the comparison of the results obtained by the students, the teachers and the platform; we found that students in the school study showed a high degree of technology ownership and this was the same for the performance shown on the technological standards. It was established that teachers play a key role in developing the techno­logical appropriation of students and performance in technology standards.

  12. ISO: international standards development for nuclear technology

    International Nuclear Information System (INIS)

    Becker, K.

    1981-01-01

    The importance of internationally recognized standards for nuclear technology and safety is rapidly increasing for technical as well as economical and political reasons such as public acceptance and nuclear technology transfer to developing countries. The need for such standards is also evident because of the large number of nuclear installations sited close to international borders, and the export of nuclear installations from relatively few supplier countries to a large number of user countries. It is the purpose of this report to describe briefly the history, organizational structures and procedures, goals, accomplishments, problems, and future needs of the relevant activities of the International Organization for Standardization (ISO). ISO is composed of the partly governmental, partly non-governmental national standards bodies of 86 countries including China. The work of its Technical Committee (TC) 85 'Nuclear Energy' is mostly concerned with industrial applications, contractual aspects and international communication, for the benefit of both developed and developing countries. It works in close liaison with IAEA, which develops Codes and Guides addressed mainly to the regulatory aspects of nuclear power plants in developing countries. ISO/TC 85 has four sub-committees dealing with: (a) Terminology, Definitions, Units and Symbols (Secretariat USA, four working groups (WGs)); (b) Radiation Protection (Secretariat France, ten WGs); (c) Power Reactor Technology (Secretariat Sweden, nine WGs); (d) Nuclear Fuel Technology (Secretariat F.R. Germany, seven WGs). (author)

  13. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record #833

    National Research Council Canada - National Science Library

    Fling, Rick; McClung, Christina; Burch, William; McDonnell, Patrick

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  14. Standardized UXO Technology Demonstration Site, Woods Scoring Record Number 486

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  15. Extended Temperature Solar Cell Technology Development

    Science.gov (United States)

    Landis, Geoffrey A.; Jenkins, Phillip; Scheiman, David; Rafaelle, Ryne

    2004-01-01

    Future NASA missions will require solar cells to operate both in regimes closer to the sun, and farther from the sun, where the operating temperatures will be higher and lower than standard operational conditions. NASA Glenn is engaged in testing solar cells under extended temperature ranges, developing theoretical models of cell operation as a function of temperature, and in developing technology for improving the performance of solar cells for both high and low temperature operation.

  16. Fuel Cell and Hydrogen Technologies Program | Hydrogen and Fuel Cells |

    Science.gov (United States)

    NREL Fuel Cell and Hydrogen Technologies Program Fuel Cell and Hydrogen Technologies Program Through its Fuel Cell and Hydrogen Technologies Program, NREL researches, develops, analyzes, and validates fuel cell and hydrogen production, delivery, and storage technologies for transportation

  17. 'Standards' on the bench : Do standards for technological literacy render an adequate image of technology?

    NARCIS (Netherlands)

    Ghaemi Nia, M.M.; de Vries, M.J.

    2016-01-01

    The technological literacy of students has recently become one of the primary goals of education in countries such as the USA, England, New Zealand, Australia, and so forth. However the question here is whether these educations - their long-term policy documents as well as the standards they

  18. "Standards" on the Bench: Do Standards for Technological Literacy Render an Adequate Image of Technology?

    Science.gov (United States)

    Nia, Mahdi G.; de Vries, Marc J.

    2016-01-01

    The technological literacy of students has recently become one of the primary goals of education in countries such as the USA, England, New Zealand, Australia, and so forth. However the question here is whether these educations--their long-term policy documents as well as the standards they provide in particular--address sufficient learning about…

  19. Engineering and "Standards for Technological Literacy."

    Science.gov (United States)

    Gorham, Douglas

    2002-01-01

    Describes the relationship between engineering and technological literacy, criteria used by the Accrediting Board for Engineering and Technology, and the role of professional engineering societies in promoting technological literacy. (SK)

  20. Design for manufacturability of a VDSM standard cell library

    International Nuclear Information System (INIS)

    Zhou Chong; Zeng Jianping; Chen Lan; Yin Minghui; Zhao Jie

    2012-01-01

    This paper presents a method of designing a 65 nm DFM standard cell library. By reducing the amount of the library largely, the process of optical proximity correction (OPC) becomes more efficient and the need for large storage is reduced. This library is more manufacture-friendly as each cell has been optimized according to the DFM rule and optical simulation. The area penalty is minor compared with traditional library, and the timing, as well as power has a good performance. Furthermore, this library has passed the test from the Technology Design Department of Foundry. The result shows this DFM standard cell library has advantages that improve the yield. (semiconductor integrated circuits)

  1. Microscale technologies for cell engineering

    CERN Document Server

    Gaharwar, Akhilesh

    2016-01-01

    This book offers readers cutting-edge research at the interface of polymer science and engineering, biomedical engineering, materials science, and biology. State-of-the-art developments in microscale technologies for cell engineering applications are covered, including technologies relevant to both pluripotent and adult stem cells, the immune system, and somatic cells of the animal and human origin. This book bridges the gap in the understanding of engineering biology at multiple length scale, including microenvironmental control, bioprocessing, and tissue engineering in the areas of cardiac, cartilage, skeletal, and vascular tissues, among others. This book also discusses unique, emerging areas of micropatterning and three-dimensional printing models of cellular engineering, and contributes to the better understanding of the role of biophysical factors in determining the cell fate. Microscale Technologies for Cell Engineering is valuable for bioengineers, biomaterial scientists, tissue engineers, clinicians,...

  2. The Complete Picture: "Standards for Technological Literacy" and "Advancing Excellence in Technological Literacy."

    Science.gov (United States)

    Technology Teacher, 2003

    2003-01-01

    Provides an overview of the "Standards for Technological Literacy: Content for the Study of Technology" (STL) and "Advancing Excellence in Technological Literacy: Student Assessment, Professional Development, and Program Standards" (AETL). Shows how the documents work together to advance the technological literacy of technology educators and K-12…

  3. Bounded Rationality at Large: Technological Standards in Airwaves Auctions

    NARCIS (Netherlands)

    Bruggeman, J.P.; Visser, Hendrik Jan; Visser, H.J.; van Rossum, Wouter

    2003-01-01

    In industries characterized by several technological standards, each with positive network externalities, competition is different from industries with technologically "loosely coupled" organizations. We therefore expected that in airwaves auctions for mobile telephony in the U.S., network

  4. DICOM standard in computer-aided medical technologies

    International Nuclear Information System (INIS)

    Plotnikov, A.V.; Prilutskij, D.A.; Selishchev, S.V.

    1997-01-01

    The paper outlines one of the promising standards to transmit images in medicine, in radiology in particular. the essence of the standard DICOM is disclosed and promises of its introduction into computer-aided medical technologies

  5. Standards for Technological Literacy: Past, Present, and Future

    Science.gov (United States)

    Dugger, William E., Jr; Moye, Johnny J.

    2018-01-01

    "Standards for Technological Literacy: Content for the Study of Technology (STL)" provides the content for what every technologically literate student should know and be able to do. It "defines what the study of technology in Grades K-12 should be, but it does not lay out a curriculum" (ITEA/ITEEA, 2000/2002/2007, p. 200).…

  6. Hybrid Fuel Cell Technology Overview

    Energy Technology Data Exchange (ETDEWEB)

    None available

    2001-05-31

    For the purpose of this STI product and unless otherwise stated, hybrid fuel cell systems are power generation systems in which a high temperature fuel cell is combined with another power generating technology. The resulting system exhibits a synergism in which the combination performs with an efficiency far greater than can be provided by either system alone. Hybrid fuel cell designs under development include fuel cell with gas turbine, fuel cell with reciprocating (piston) engine, and designs that combine different fuel cell technologies. Hybrid systems have been extensively analyzed and studied over the past five years by the Department of Energy (DOE), industry, and others. These efforts have revealed that this combination is capable of providing remarkably high efficiencies. This attribute, combined with an inherent low level of pollutant emission, suggests that hybrid systems are likely to serve as the next generation of advanced power generation systems.

  7. Informatics and Standards for Nanomedicine Technology

    Science.gov (United States)

    Thomas, Dennis G.; Klaessig, Fred; Harper, Stacey L.; Fritts, Martin; Hoover, Mark D.; Gaheen, Sharon; Stokes, Todd H.; Reznik-Zellen, Rebecca; Freund, Elaine T.; Klemm, Juli D.; Paik, David S.; Baker, Nathan A.

    2011-01-01

    There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information standards. Informatics methods and standards in each of these areas are critical for enabling collaboration, data sharing, unambiguous representation and interpretation of data, semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this review, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, due to gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization protocols, etc. Progress towards resolving the issues of information management in nanomedicine using informatics methods and standards discussed in this review will be essential to the rapidly growing field of nanomedicine informatics. PMID:21721140

  8. Smart grid standards specifications, requirements, and technologies

    CERN Document Server

    Sato, Takuro; Duan, Bin; Macuha, Martin; Zhou, Zhenyu; Wu, Jun; Tariq, Muhammad; Asfaw, Solomon A

    2015-01-01

    With numerous existing Smart Grid standards, it is clear that governments and industrial organizations world-wide have understood and acknowledged the critical role they play. This timely book is a useful guide for Smart Grid professionals in easily classifying fundamental Smart Grid standards, and to quickly find the building blocks they need to analyse and implement a Smart Grid system. The standards are organized in a systematic manner that aids identification, according to grid requirements. It also covers broader Smart Grid areas including, but not limited to, the following: A fully c

  9. Fuel Cell Technology Status Analysis | Hydrogen and Fuel Cells | NREL

    Science.gov (United States)

    Technology Status Analysis Fuel Cell Technology Status Analysis Get Involved Fuel cell developers interested in collaborating with NREL on fuel cell technology status analysis should send an email to NREL's Technology Validation Team at techval@nrel.gov. NREL's analysis of fuel cell technology provides objective

  10. Outdoor Lighting Networks: Market, Technologies and Standards

    NARCIS (Netherlands)

    Cavalcanti, D.; Wang, J.; Chen, R.; Jiang , D.; Yang, Y.

    2012-01-01

    Providing the right amount of light where and when it is needed is an opportunity to transform today’s cities into smart and livable urban spaces. New technologies are being introduced, such are adaptivecontrols and outdoor lighting networks, which can deliver energy andcost savings through adaptive

  11. Simulation and Modeling Capability for Standard Modular Hydropower Technology

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pries, Jason L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burress, Timothy A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kao, Shih-Chieh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mobley, Miles H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Kyutae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Curd, Shelaine L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tsakiris, Achilleas [Univ. of Tennessee, Knoxville, TN (United States); Mooneyham, Christian [Univ. of Tennessee, Knoxville, TN (United States); Papanicolaou, Thanos [Univ. of Tennessee, Knoxville, TN (United States); Ekici, Kivanc [Univ. of Tennessee, Knoxville, TN (United States); Whisenant, Matthew J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Welch, Tim [US Department of Energy, Washington, DC (United States); Rabon, Daniel [US Department of Energy, Washington, DC (United States)

    2017-08-01

    Grounded in the stakeholder-validated framework established in Oak Ridge National Laboratory’s SMH Exemplary Design Envelope Specification, this report on Simulation and Modeling Capability for Standard Modular Hydropower (SMH) Technology provides insight into the concepts, use cases, needs, gaps, and challenges associated with modeling and simulating SMH technologies. The SMH concept envisions a network of generation, passage, and foundation modules that achieve environmentally compatible, cost-optimized hydropower using standardization and modularity. The development of standardized modeling approaches and simulation techniques for SMH (as described in this report) will pave the way for reliable, cost-effective methods for technology evaluation, optimization, and verification.

  12. Technology standards for structure, etc. concerning nuclear power generating facilities

    International Nuclear Information System (INIS)

    1977-01-01

    Based on the Ordinance for the Technology Standards concerning Nuclear Power Generating Facilities, the technology standards are established for the vessels of class 1 to 4 (including reactor pressure vessels, reactor containment vessels, etc.), the pipes of class 1 to 3, safety valves, pressure test and monitoring test specimens. Those specified are materials, nondestructive tests, structures, shapes, shells, flanges, etc. for the vessels and the pipes, and so on. (Mori, K.)

  13. Fuel cell vehicles: technological solution

    International Nuclear Information System (INIS)

    Lopez Martinez, J. M.

    2004-01-01

    Recently it takes a serious look at fuel cell vehicles, a leading candidate for next-generation vehicle propulsion systems. The green house effect and air quality are pressing to the designers of internal combustion engine vehicles, owing to the manufacturers to find out technological solutions in order to increase the efficiency and reduce emissions from the vehicles. On the other hand, energy source used by currently propulsion systems is not renewable, the well are limited and produce CO 2 as a product from the combustion process. In that situation, why fuel cell is an alternative of internal combustion engine?

  14. [THE TECHNOLOGY "CELL BLOCK" IN CYTOLOGICAL PRACTICE].

    Science.gov (United States)

    Volchenko, N N; Borisova, O V; Baranova, I B

    2015-08-01

    The article presents summary information concerning application of "cell block" technology in cytological practice. The possibilities of implementation of various modern techniques (immune cytochemnical analysis. FISH, CISH, polymerase chain reaction) with application of "cell block" method are demonstrated. The original results of study of "cell block" technology made with gelatin, AgarCyto and Shadon Cyoblock set are presented. The diagnostic effectiveness of "cell block" technology and common cytological smear and also immune cytochemical analysis on samples of "cell block" technology and fluid cytology were compared. Actually application of "cell block" technology is necessary for ensuring preservation of cell elements for subsequent immune cytochemical and molecular genetic analysis.

  15. Fuel Cell and Hydrogen Technology Validation | Hydrogen and Fuel Cells |

    Science.gov (United States)

    NREL Fuel Cell and Hydrogen Technology Validation Fuel Cell and Hydrogen Technology Validation The NREL technology validation team works on validating hydrogen fuel cell electric vehicles; hydrogen fueling infrastructure; hydrogen system components; and fuel cell use in early market applications such as

  16. Hydrogen fuel cell engines and related technologies

    Science.gov (United States)

    2001-12-01

    The manual documents the first training course developed on the use of hydrogen fuel cells in transportation. The manual contains eleven modules covering hydrogen properties, use and safety; fuel cell technology and its systems, fuel cell engine desi...

  17. Standard Modular Hydropower Technology Acceleration Workshop: Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mobley, Miles H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fernandez, Alisha R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    In support of the Department of Energy (DOE) funded Standard Modular Hydropower (SMH) Technology Acceleration project, Oak Ridge National Laboratory (ORNL) staff convened with five small hydropower technology entrepreneurs on June 14 and 15, 2017 to discuss gaps, challenges, and opportunities for small modular hydropower development. The workshop was designed to walk through SMH concepts, discuss the SMH research vision, assess how each participant’s technology aligns with SMH concepts and research, and identify future pathways for mutually beneficial collaboration that leverages ORNL expertise and entrepreneurial industry experience. The goal coming out of the workshop is to advance standardized, scalable, modular hydropower technologies and development approaches with sustained and open dialogue among diverse stakeholder groups.

  18. The Canadian Association of Radiologists national standards for technology

    International Nuclear Information System (INIS)

    Hynes, D.M.

    1997-01-01

    Unlike any other technological development before it, teleradiology is revolutionizing the diagnostic medical imaging field by enabling broad access to radiological images. Images can today be transmitted between departments or between hospitals. Doctors in remote areas can share images with specialists in larger centres for consultation. Physicians can access hospital records from their office or home computer. Teleradiology also offers valuable educational opportunities. Like other technologies, however, the implementation and continuing development of teleradiology requires careful consideration of issues related to image quality, patient care, security of patient records, and other important matters. The following standard was prepared by the CAR Expert Advisory Panel on Teleradiology Standards in collaboration with the Ontario Association of Radiologists Teleradiology Committee to provide a model for teleradiology applications. The standard is based upon U.S. standards prepared by the American College of Radiology. (author). 21 refs

  19. Patterns in Standards and Technologies for Economic Information Systems Interoperability

    Directory of Open Access Journals (Sweden)

    Vasile Irimia

    2012-06-01

    Full Text Available This paper presets results from a review of the current standards used for collaboration between economic information systems, including web services and service oriented architecture, EDI, ebXML framework, RosettaNet framework, cXML, xCBL UBL, BPMN, BPEL, WS-CDL, ASN.1, and others. Standards have a key role in promoting economic information system interoperability, and thus enable collaboration. Analyzing the current standards, technologies and applications used for economic information systems interoperability has revealed a common pattern that runs through all of them. From this pattern we construct a basic model of interoperability around which we relate and judge all standards, technologies and applications for economic information systems interoperability.

  20. Information and Communication Technology (ICT) Standards and Guidelines. Final rule.

    Science.gov (United States)

    2017-01-18

    We, the Architectural and Transportation Barriers Compliance Board (Access Board or Board), are revising and updating, in a single rulemaking, our standards for electronic and information technology developed, procured, maintained, or used by Federal agencies covered by section 508 of the Rehabilitation Act of 1973, as well as our guidelines for telecommunications equipment and customer premises equipment covered by Section 255 of the Communications Act of 1934. The revisions and updates to the section 508-based standards and section 255-based guidelines are intended to ensure that information and communication technology covered by the respective statutes is accessible to and usable by individuals with disabilities.

  1. Linear thermal expansion coefficient measurement technology in hot cell

    International Nuclear Information System (INIS)

    Park, Dae Gyu; Choo, Yong Sun; Ahn, Sang Bok; Hong, Kwon Pyo; Lee, K. S.

    1998-06-01

    To establish linear thermal expansion coefficient measurement technology in hot cell, we reviewed and evaluated various measuring technology by paper and these were compared with the data produced with pre-installed dilatometer in hot cell. Detailed contents are as follows; - The theory of test. - Review of characteristics for various measurement technology and compatibility with hot cell. - Review of standard testing regulations(ASTM). - System calibration of pre-installed dilatometer. - Performance test of pre-installed dilatometer. (author). 12 refs., 15 tabs., 8 figs

  2. New Buildings Energy Performance Improvement through Incorporation of New Proven Technologies into Standard Designs. Standard Design for TEMF

    National Research Council Canada - National Science Library

    Zhivov, Alexander M

    2004-01-01

    ISSUES: Current Army Standard Designs don't specify potential energy saving and sustainable design opportunities, available energy saving technologies, and technologies resulting in better indoor air quality...

  3. Standardized Testing Program for Solid-State Hydrogen Storage Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Michael A. [Southwest Research Institute; Page, Richard A. [Southwest Research Institute

    2012-07-30

    In the US and abroad, major research and development initiatives toward establishing a hydrogen-based transportation infrastructure have been undertaken, encompassing key technological challenges in hydrogen production and delivery, fuel cells, and hydrogen storage. However, the principal obstacle to the implementation of a safe, low-pressure hydrogen fueling system for fuel-cell powered vehicles remains storage under conditions of near-ambient temperature and moderate pressure. The choices for viable hydrogen storage systems at the present time are limited to compressed gas storage tanks, cryogenic liquid hydrogen storage tanks, chemical hydrogen storage, and hydrogen absorbed or adsorbed in a solid-state material (a.k.a. solid-state storage). Solid-state hydrogen storage may offer overriding benefits in terms of storage capacity, kinetics and, most importantly, safety.The fervor among the research community to develop novel storage materials had, in many instances, the unfortunate consequence of making erroneous, if not wild, claims on the reported storage capacities achievable in such materials, to the extent that the potential viability of emerging materials was difficult to assess. This problem led to a widespread need to establish a capability to accurately and independently assess the storage behavior of a wide array of different classes of solid-state storage materials, employing qualified methods, thus allowing development efforts to focus on those materials that showed the most promise. However, standard guidelines, dedicated facilities, or certification programs specifically aimed at testing and assessing the performance, safety, and life cycle of these emergent materials had not been established. To address the stated need, the Testing Laboratory for Solid-State Hydrogen Storage Technologies was commissioned as a national-level focal point for evaluating new materials emerging from the designated Materials Centers of Excellence (MCoE) according to

  4. Developing global health technology standards: what can other industries teach us?

    Science.gov (United States)

    Masum, Hassan; Lackman, Rebecca; Bartleson, Karen

    2013-10-17

    There is a lack of effective and affordable technologies to address health needs in the developing world. One way to address problems of innovation and affordability is to design global health technologies to follow agreed-upon standards. This Debate article argues that we can better develop standards for global health technologies if we learn lessons from other industries. The article's Background section begins by explaining why standards are needed in global health. For example, if global health technologies can be modularized into independent interfacing parts, these parts can then interact via well-defined standards in a "plug and play" fashion. This can avoid development of mutually incompatible solutions by different organizations, speed the pace of innovation, unlock health systems from single providers and approaches, and lower barriers to entry. The Background then gives a brief primer on standards and discusses incentives for health standards. The article's Discussion section begins with brief relevant cases of standards development from other industries, including electricity, container shipping, CD standards, Universal Serial Bus (USB), and the Internet. It then explores lessons from these and other industries that suggest how to develop standards for global health technologies. The remainder of the Discussion considers intellectual property and regulatory issues and standards-based global health business models, and ends with a checklist of considerations for health standards development leaders. (The associated Additional file discusses observations from standards development for cell phones and semiconductors, as well as challenges in the standards development process itself.) Throughout the article, point-of-care diagnostics are used as an illustrative example. An initiative is already underway to explore standardized diagnostics platforms. This Debate article aims to convince the reader that standards can benefit global health technologies if we

  5. Making Use of the New Student Assessment Standards To Enhance Technological Literacy.

    Science.gov (United States)

    Russell, Jill

    2003-01-01

    Describes the student assessment standards outlined in "Advancing Excellence in Technological Literacy: Student Assessment, Professional Development, and Program Standards," a companion to the "Standards for Technological Literacy." Discusses how the standards apply to everyday teaching practices. (JOW)

  6. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record Number 842

    National Research Council Canada - National Science Library

    Karwatka, Michael; Fling, Rick; McClung, Christina; Banta, Matthew; Burch, William; McDonnell, Patrick

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Michael Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

  7. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 396

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  8. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 805

    National Research Council Canada - National Science Library

    Karwatka, Michael; Fling, Rick; McClung, Christina

    2007-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Michael Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

  9. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 268

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  10. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record Number 312

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Archiable, Robert; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Scoring Committee...

  11. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record No. 898

    National Research Council Canada - National Science Library

    Burch, William; Fling, Rick; McClung, Christina; Lombardo, Leonardo; McDonnell, Patrick

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid Field. This Scoring Record was coordinated by William Burch and the Standardized UXO Technology Demonstration Site Scoring Committee...

  12. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 769

    National Research Council Canada - National Science Library

    Archiable, Robert; Fling, Rick; McClung, Christina; Teefy, Dennis; Burch, William; Packer, Bonnie; Banta, Matthew

    2006-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. Scoring Records have been coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  13. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 792

    National Research Council Canada - National Science Library

    Karwatka, Mike; Packer, Bonnie

    2006-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. Scoring Records have been coordinated by Mike Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

  14. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record No. 896

    National Research Council Canada - National Science Library

    Burch, William; Fling, Rick; McClung, Christina

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid Field. This Scoring Record was coordinated by William Burch and the Standardized UXO Technology Demonstration Site Scoring Committee...

  15. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record No. 257

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Robitaille, George; Boutin, Matthew; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  16. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 830

    National Research Council Canada - National Science Library

    Teefy, Dennis

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  17. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record Number 431

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  18. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 834

    National Research Council Canada - National Science Library

    Teefy, Dennis; Fling, Rick; McClung, Christina

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  19. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record No. 397

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Robitaille, George; Boutin, Matthew; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  20. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 252

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  1. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record Number 691

    National Research Council Canada - National Science Library

    Overbay, Jr., Larry; Watts, Kimberly; Fling, Rick; McClung, Christina; Banta, Matthew

    2006-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site blind grid. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  2. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 832

    National Research Council Canada - National Science Library

    Teefy, Dennis

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  3. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record No. 237

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Robitaille, George; Boutin, Matthew; Fling, Rick; McClung, Christina

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  4. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 906 (Sky Research, Inc.)

    National Research Council Canada - National Science Library

    McClung, J. S; Burch, William; Fling, Rick; McClung, Christina; Lombardo, Leonardo; McDonnell, Patrick

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by William Burch and the Standardized UXO Technology Demonstration Site Scoring Committee...

  5. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 764

    National Research Council Canada - National Science Library

    Overbay, Larry; Watts, Kimberly

    2006-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  6. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 831

    National Research Council Canada - National Science Library

    Teefy, Dennis

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  7. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 690

    National Research Council Canada - National Science Library

    Overbay, Larry

    2005-01-01

    ...) utilizing the YPC Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Scoring Committee...

  8. Standardized UXO Technology Demonstration Site. Open Field Scoring Record Number 154

    National Research Council Canada - National Science Library

    Overbay, Larry

    2004-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  9. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 379

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ... (UXO) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  10. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 354

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Archiable, Robert; McClung, Christina

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  11. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 311

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  12. Standardized UXO Technology Demonstration Site Open Field Scoring Recording Number 231 (Human Factors Applications, Inc.)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbuy and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  13. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 426

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Archiable, Robert; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  14. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 657

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  15. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 129

    National Research Council Canada - National Science Library

    Overbay, Larry

    2004-01-01

    ...) utilizing the APO Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  16. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 229

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  17. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 411

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  18. Standardized UXO Technology Demonstration Site, Open Field Scoring Record No. 897

    National Research Council Canada - National Science Library

    Burch, William; Fling, Rick; McClung, Christina

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by William Burch and the Standardized UXO Technology Demonstration Site Scoring Committee...

  19. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 673 (Naval Research Laboratories)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinate by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  20. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 169

    National Research Council Canada - National Science Library

    Overbay, Larry; Archiable, Robert; McClung, Christina; Robitaille, George

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  1. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 492 (Shaw Environmental, Inc.)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  2. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 442

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Boutin, Matthew; Archiable, Robert; Fling, Rick; McClung, Christina; Robitaille, George

    2005-01-01

    ...) unitizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  3. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 201

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Fling, Rick; Robitaille, George

    2004-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  4. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 668 (NAEVA Geophysics, Inc.)

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ...) utilizing they PG Standardized UXO Technology Demonstration Site Open Field. Scoring Records have been coordinate by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  5. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 165

    National Research Council Canada - National Science Library

    Overbay, Larry

    2004-01-01

    ...) utilizing the APO Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  6. Standardized UXO Technology Demonstration Site, Open Field Scoring Record Number 638

    National Research Council Canada - National Science Library

    Overbay, Larry, Jr; Robitaille, George; Boutin, Matthew; Archiable, Robert; McClung, Christina

    2005-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and the Standardized UXO Technology Demonstration Site Scoring Committee...

  7. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 857

    National Research Council Canada - National Science Library

    Fling, Rick; McClung, Christina; Banta, Matthew; Burch, William; McDonnell, Patrick

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by Dennis Teefy and the Standardized UXO Technology Demonstration Site Scoring Committee...

  8. Technology status: Batteries and fuel cells

    Science.gov (United States)

    Fordyce, J. S.

    1978-01-01

    The current status of research and development programs on batteries and fuel cells and the technology goals being pursued are discussed. Emphasis is placed upon those technologies relevant to earth orbital electric energy storage applications.

  9. IEA Energy Technology Essentials: Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-04-15

    The IEA Energy Technology Essentials series offers concise four-page updates on the different technologies for producing, transporting and using energy. Fuel cells is the topic covered in this edition.

  10. Status and promise of fuel cell technology

    Energy Technology Data Exchange (ETDEWEB)

    Williams, M.C. [National Energy Technology Lab., Pittsburgh, PA (United States). Dept. of Energy

    2001-09-01

    The niche or early entry market penetration by ONSI and its phosphoric acid fuel cell technology has proven that fuel cells are reliable and suitable for premium power and other opportunity fuel niche market applications. Now, new fuel cell technologies - solid oxide fuel cells, molten carbonate fuel cells, and polymer electrolyte fuel cells - are being developed for near-term distributed generation shortly after 2003. Some of the evolving fuel cell systems are incorporating gas turbines in hybrid configurations. The combination of the gas turbine with the fuel cell promises to lower system costs and increase efficiency to enhance market penetration. Market estimates indicate that significant early entry markets exist to sustain the initially high cost of some distributed generation technologies. However, distributed generation technologies must have low introductory first cost, low installation cost, and high system reliability to be viable options in competitive commercial and industrial markets. In the long-term, solid state fuel cell technology with stack costs under $100/kilowatt (kW) promises deeper and wider market penetration in a range of applications including a residential, auxillary power, and the mature distributed generation markets. The solid state energy conversion alliance (SECA) with its vision for fuel cells in 2010 was recently formed to commercialize solid state fuel cells and realize the full potential of the fuel cell technology. Ultimately, the SECA concept could lead to megawatt-size fuel-cell systems for commercial and industrial applications and Vision 21 fuel cell turbine hybrid energy plants in 2015. (orig.)

  11. Machine-to-machine communications architectures, technology, standards, and applications

    CERN Document Server

    Misic, Vojislav B

    2014-01-01

    With the number of machine-to-machine (M2M)-enabled devices projected to reach 20 to 50 billion by 2020, there is a critical need to understand the demands imposed by such systems. Machine-to-Machine Communications: Architectures, Technology, Standards, and Applications offers rigorous treatment of the many facets of M2M communication, including its integration with current technology.Presenting the work of a different group of international experts in each chapter, the book begins by supplying an overview of M2M technology. It considers proposed standards, cutting-edge applications, architectures, and traffic modeling and includes case studies that highlight the differences between traditional and M2M communications technology.Details a practical scheme for the forward error correction code designInvestigates the effectiveness of the IEEE 802.15.4 low data rate wireless personal area network standard for use in M2M communicationsIdentifies algorithms that will ensure functionality, performance, reliability, ...

  12. Standardization of green building technologies for environment design

    Directory of Open Access Journals (Sweden)

    Benuzh Andrey

    2016-01-01

    Full Text Available The article describes the structure and field of standardization ISO / TC 205 “Building environment design”, provides examples of green building technologies. The main purpose of the article is to show the interaction between international ISO / TC 205 “Building environment design” and created in Russia in 2016 the Technical Committee of Standardization № 366 “Green technology of the build environment and green innovative products”. Both of these technical committees promote green building technologies for environment design, thereby deal with the negative impact on the environment and the reasons of global warming. Instead of buildings that attempt to suppress and overcome nature, why not design buildings that integrate with the environment, on every possible level? The international standardization work which ISO/TC 205 “Building environment design” performs seeks, in addition to lowering trade barriers for engineering design, to promote and facilitate the design of high performance buildings: higher performing as economic assets for their owners, higher performing as buildings that provide amenable indoor environment for their occupants, and higher performing with respect to resource utilization and environmental impact.

  13. Assessment of technologies to meet a low carbon fuel standard.

    Science.gov (United States)

    Yeh, Sonia; Lutsey, Nicholas P; Parker, Nathan C

    2009-09-15

    California's low carbon fuel standard (LCFS) was designed to incentivize a diverse array of available strategies for reducing transportation greenhouse gas (GHG) emissions. It provides strong incentives for fuels with lower GHG emissions, while explicitly requiring a 10% reduction in California's transportation fuel GHG intensity by 2020. This paper investigates the potential for cost-effective GHG reductions from electrification and expanded use of biofuels. The analysis indicates that fuel providers could meetthe standard using a portfolio approach that employs both biofuels and electricity, which would reduce the risks and uncertainties associated with the progress of cellulosic and battery technologies, feedstock prices, land availability, and the sustainability of the various compliance approaches. Our analysis is based on the details of California's development of an LCFS; however, this research approach could be generalizable to a national U.S. standard and to similar programs in Europe and Canada.

  14. Limitations of Commercializing Fuel Cell Technologies

    Science.gov (United States)

    Nordin, Normayati

    2010-06-01

    Fuel cell is the technology that, nowadays, is deemed having a great potential to be used in supplying energy. Basically, fuel cells can be categorized particularly by the kind of employed electrolyte. Several fuel cells types which are currently identified having huge potential to be utilized, namely, Solid Oxide Fuel Cells (SOFC), Molten Carbonate Fuel Cells (MCFC), Alkaline Fuel Cells (AFC), Phosphoric Acid Fuel Cells (PAFC), Polymer Electron Membrane Fuel Cell (PEMFC), Direct Methanol Fuel Cells (DMFC) and Regenerative Fuel Cells (RFC). In general, each of these fuel cells types has their own characteristics and specifications which assign the capability and suitability of them to be utilized for any particular applications. Stationary power generations and transport applications are the two most significant applications currently aimed for the fuel cell market. It is generally accepted that there are lots of advantages if fuel cells can be excessively commercialized primarily in context of environmental concerns and energy security. Nevertheless, this is a demanding task to be accomplished, as there is some gap in fuel cells technology itself which needs a major enhancement. It can be concluded, from the previous study, cost, durability and performance are identified as the main limitations to be firstly overcome in enabling fuel cells technology become viable for the market.

  15. The interplay between standardization and technological change : a study on wireless technologies, technological trajectories, and essential patent claims

    NARCIS (Netherlands)

    Bekkers, R.N.A.; Martinelli, A.

    2010-01-01

    In many technology fields, standardization is the primary method of achieving alignment between actors. Especially if strong network effects and increasing returns are present, the market often ends up with a single standard that dominates the technical direction, activities and search heuristics,

  16. Challenges in amorphous silicon solar cell technology

    NARCIS (Netherlands)

    Swaaij, van R.A.C.M.M.; Zeman, M.; Korevaar, B.A.; Smit, C.; Metselaar, J.W.; Sanden, van de M.C.M.

    2000-01-01

    Hydrogenated amorphous silicon is nowadays extensively used for a range of devices, amongst others solar cells, Solar cell technology has matured over the last two decades and resulted in conversion efficiencies in excess of 15%. In this paper the operation of amorphous silicon solar cells is

  17. Investigations of Laser Pumped Gas Cell Atomic Frequency Standard

    National Research Council Canada - National Science Library

    Volk, C. H; Camparo, J. C; Frueholz, R. P

    1981-01-01

    Recently it has been suggested that the performance characteristics of a rubidium gas cell atomic frequency standard might be improved by replacing the standard rubidium discharge lamp with a single mode laser diode...

  18. Environmental aspects of battery and fuel cell technologies

    International Nuclear Information System (INIS)

    1992-10-01

    This report was commissioned by the UK Department of Trade and Industry in order to understand the policy, infrastructural and standards implications of increased use of batteries and fuel cells. In order to meet these requirements, the following areas have been examined: environmental initiatives related to power generation and transport in a pan-European context; the status of alternative technologies, specifically batteries and fuel cells; the market potential of battery and fuel cell based technologies in transport and power generation; environmental life cycle and cost benefit analyses of these technologies; the implications of the use of alternative technologies on the UK infrastructure. Each of these areas is covered briefly in the main body of the report and discussed in greater detail in six appendices. Overall there are 51 figures, 38 tables and 20 references. (UK)

  19. Development of PEM fuel cell technology at international fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, D.J.

    1996-04-01

    The PEM technology has not developed to the level of phosphoric acid fuel cells. Several factors have held the technology development back such as high membrane cost, sensitivity of PEM fuel cells to low level of carbon monoxide impurities, the requirement to maintain full humidification of the cell, and the need to pressurize the fuel cell in order to achieve the performance targets. International Fuel Cells has identified a hydrogen fueled PEM fuel cell concept that leverages recent research advances to overcome major economic and technical obstacles.

  20. Cell sheet technology and cell patterning for biofabrication

    Energy Technology Data Exchange (ETDEWEB)

    Hannachi, Imen Elloumi; Yamato, Masayuki; Okano, Teruo [Institute of Advanced Biomedical Engineering and Science, Tokyo Women' s Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo (Japan)

    2009-06-01

    We have developed cell sheet technology as a modern method for the fabrication of functional tissue-like and organ-like structures. This technology allows for a sheet of interconnected cells and cells in full contact with their natural extracellular environment to be obtained. A cell sheet can be patterned and composed according to more than one cell type. The key technology of cell sheet engineering is that a fabricated cell sheet can be harvested and transplanted utilizing temperature-responsive surfaces. In this review, we summarize different aspects of cell sheet engineering and provide a survey of the application of cell sheets as a suitable material for biofabrication and clinics. Moreover, since cell micropatterning is a key tool for cell sheet engineering, in this review we focus on the introduction of our approaches to cell micropatterning and cell co-culture to the principles of automation and how they can be subjected to easy robotics programming. Finally, efforts towards making cell sheet technology suitable for biofabrication and robotic biofabrication are also summarized. (topical review)

  1. A critical assessment of fuel cell technology

    International Nuclear Information System (INIS)

    Lindstroem, O.

    1994-01-01

    Cold combustion is a promised technology to mankind since the middle of the last century. The fuel cell may at last become the energy machine of the one to come after a long journey on a road bordered with expectations, successes and disappointments. Ten billion people will need the cell for their well-being. The progress and the state-of-art is assessed by means of figures of merit for performance, normalized to standard conditions, life and variability. State-of-art current densities for multi-kW stacks operating on atmospheric pressure air at 0.74 V cell voltage (50% efficiency, HHV) are estimated to be 150 mA/cm 2 for MCFC, 160 mA/cm 2 for AFC, 239 mA/cm 2 for PEFC and 270 mA/cm 2 for SOFC. PAFC gives 260 mA/cm 2 at 0.66 V and DMFC 100 mA/cm 2 at 0.37 V. Decay rates are about 1%/1000 h for PEFC, PAFC and SOFC compared to 2%/1000 h for AFC and 3%/1000 h for MCFC. Coefficients of variation for cell voltages amount to about 1% for all options, except for MCFC with 3-4%. Improvement of cell performance after 1975 is nil to moderate, except for SOFC with a consistent annual improvement of about 10%. There is room for further development of terrestrial AFCs towards 300-400 mA/cm 2 considering the figure 800 mA/cm 2 for oxygen AFCs. Life and cost will decide the future of the fuel cell. Prospects are not as good as they could be. The fuel cell community lacks understanding of the basics of fuel processing, as demonstrated by the widespread misbelief ('the CO 2 syndrome') that CO 2 cannot be removed cost effectively from a hydrogen feed (which is practiced in every NH 3 plant around the world). The competition, read the gas turbine, has to be taken very seriously. Emphasis has to be shifted from premature demonstrations to R and D on fundamental problems, which have been around too long. 34 refs

  2. Solar cell materials developing technologies

    CERN Document Server

    Conibeer, Gavin J

    2014-01-01

    This book presents a comparison of solar cell materials, including both new materials based on organics, nanostructures and novel inorganics and developments in more traditional photovoltaic materials. It surveys the materials and materials trends in the field including third generation solar cells (multiple energy level cells, thermal approaches and the modification of the solar spectrum) with an eye firmly on low costs, energy efficiency and the use of abundant non-toxic materials.

  3. Technologies for Single-Cell Isolation.

    Science.gov (United States)

    Gross, Andre; Schoendube, Jonas; Zimmermann, Stefan; Steeb, Maximilian; Zengerle, Roland; Koltay, Peter

    2015-07-24

    The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting) respectively Flow cytometry (33% usage), laser microdissection (17%), manual cell picking (17%), random seeding/dilution (15%), and microfluidics/lab-on-a-chip devices (12%) are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field.

  4. Technologies for Single-Cell Isolation

    Science.gov (United States)

    Gross, Andre; Schoendube, Jonas; Zimmermann, Stefan; Steeb, Maximilian; Zengerle, Roland; Koltay, Peter

    2015-01-01

    The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting) respectively Flow cytometry (33% usage), laser microdissection (17%), manual cell picking (17%), random seeding/dilution (15%), and microfluidics/lab-on-a-chip devices (12%) are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field. PMID:26213926

  5. Technologies for Single-Cell Isolation

    Directory of Open Access Journals (Sweden)

    Andre Gross

    2015-07-01

    Full Text Available The handling of single cells is of great importance in applications such as cell line development or single-cell analysis, e.g., for cancer research or for emerging diagnostic methods. This review provides an overview of technologies that are currently used or in development to isolate single cells for subsequent single-cell analysis. Data from a dedicated online market survey conducted to identify the most relevant technologies, presented here for the first time, shows that FACS (fluorescence activated cell sorting respectively Flow cytometry (33% usage, laser microdissection (17%, manual cell picking (17%, random seeding/dilution (15%, and microfluidics/lab-on-a-chip devices (12% are currently the most frequently used technologies. These most prominent technologies are described in detail and key performance factors are discussed. The survey data indicates a further increasing interest in single-cell isolation tools for the coming years. Additionally, a worldwide patent search was performed to screen for emerging technologies that might become relevant in the future. In total 179 patents were found, out of which 25 were evaluated by screening the title and abstract to be relevant to the field.

  6. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 740

    National Research Council Canada - National Science Library

    Overbay, Jr., Larry; Fling, Rick; McClug, Christina; Watts, Kimberly; Banta, Matthew

    2006-01-01

    The objective in the Standardized UXO Technology Demonstration Site Program is to evaluate the detection and discrimination capabilities of a given technology under various field and soil conditions...

  7. Alkaline fuel cell technology in the lead

    International Nuclear Information System (INIS)

    Nor, J.K.

    2004-01-01

    The Alkaline Fuel Cell (AFC) was the first fuel cell successfully put into practice, a century after William Grove patented his 'hydrogen battery' in 1839. The space program provided the necessary momentum, and alkaline fuel cells became the power source for both the U.S. and Russian manned space flight. Astris Energi's mission has been to bring this technology down to earth as inexpensive, rugged fuel cells for everyday applications. The early cells, LABCELL 50 and LABCELL 200 were aimed at deployment in research labs, colleges and universities. They served well in technology demonstration projects such as the 1998 Mini Jeep, 2001 Golf Car and a series of portable and stationary fuel cell generators. The present third generation POWERSTACK MC250 poised for commercialization is being offered to AFC system integrators as a building block of fuel cell systems in numerous portable, stationary and transportation applications. It is also used in Astris' own E7 and E8 alkaline fuel cell generators. Astris alkaline technology leads the way toward economical, plentiful fuel cells. The paper highlights the progress achieved at Astris, improvements of performance, durability and simplicity of use, as well as the current and future thrust in technology development and commercialization. (author)

  8. Emerging Solar Technologies: Perovskite Solar Cell

    Indian Academy of Sciences (India)

    energy technologies and ... cost-effective and feasible non-silicon solar cell technologies. ..... storing in the air for long periods, and the stability reached up to .... [12] Y Liu, L A Renna, M Bag, Z A Page, P Kim, J Choi, T Emrick, D Venkatara-.

  9. Exploring Hydrogen Fuel Cell Technology

    Science.gov (United States)

    Brus, David; Hotek, Doug

    2010-01-01

    One of the most significant technological issues of the 21st Century is finding a way to fulfill the energy demands without destroying the environment through global warming and climate change. Worldwide human population is on the rise, and with it, the demand for more energy in pursuit of a higher quality of life. In the meantime, as people use…

  10. Practical silicon Light emitting devices fabricated by standard IC technology

    International Nuclear Information System (INIS)

    Aharoni, H.; Monuko du Plessis; Snyman, L.W.

    2004-01-01

    Full Text:Research activities are described with regard to the development of a comprehensive approach for the practical realization of single crystal Silicon Light Emitting Devices (Si-LEDs). Several interesting suggestions for the fabrication of such devices were made in the literature but they were not adopted by the semiconductor industry because they involve non-standard fabrication schemes, requiring special production lines. Our work presents an alternative approach, proposed and realized in practice by us, permitting the fabrication of Si-LEDs using the standard conventional fully industrialized IC technology ''as is'' without any adaptation. It enables their fabrication in the same production lines of the presently existing IC industry. This means that Si-LEDs can now be fabricated simultaneously with other components, such as transistors, on the same silicon chip, using the same masks and processing procedures. The result is that the yield, reliability, and price of the above Si-LEDs are the same as the other Si devices integrated on the same chip. In this work some structural details of several practical Si-LED's designed by us, as well as experimental results describing their performance are presented. These Si-LED's were fabricated to our specifications utilizing standard CMOS/BiCMOS technology, a fact which comprises an achievement by itself. The structure of the Si-LED's, is designed according to specifications such as the required operating voltage, overall light output intensity, its dependence(linear, or non-linear) on the input signal (voltage or current), light generations location (bulk, or near-surface), the emission pattern and uniformity. Such structural design present a problem since the designer can not use any structural parameters (such as doping levels and junction depths for example) but only those which already exist in the production lines. Since the fabrication procedures in these lines are originally designed for processing of

  11. Standardized UXO Technology Demonstration Site, Blind Grid Scoring Record No. 671

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ... (UXO) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Deomostration Site Scoring Committee...

  12. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 213

    National Research Council Canada - National Science Library

    Overbay, Larry; Archiable, Robert; McClung, Christina; Robitaille, George

    2005-01-01

    ... (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Blind Grid. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Site Scoring Committee...

  13. Standardized UXO Technology Demonstration Site Open Field Scoring Record No. 901 (Sky Research, Inc.)

    National Research Council Canada - National Science Library

    McClung, J. S; Fling, Rick; McClung, Christina; Burch, William; Lombardo, Leonardo; McDonnell, Patrick

    2008-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. This Scoring Record was coordinated by Stephen McClung and the Standardized UXO Technology Demonstration Site Scoring Committee...

  14. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 245

    National Research Council Canada - National Science Library

    Overbay, Larry

    2005-01-01

    ... (UXO) utilizing the YPG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  15. Standardized UXO Technology Demonstration Site Open Field Scoring Record Number 675

    National Research Council Canada - National Science Library

    Overbay, Larry; Robitaille, George

    2005-01-01

    ... (UXO) utilizing the APG Standardized UXO Technology Demonstration Site Open Field. The scoring record was coordinated by Larry Overbay and by the Standardized UXO Technology Demonstration Site Scoring Committee...

  16. Hybrid fuel cells technologies for electrical microgrids

    Energy Technology Data Exchange (ETDEWEB)

    San Martin, Jose Ignacio; Zamora, Inmaculada; San Martin, Jose Javier; Aperribay, Victor; Eguia, Pablo [Department of Electrical Engineering, University of the Basque Country, Alda. de Urquijo, s/n, 48013 Bilbao (Spain)

    2010-09-15

    Hybrid systems are characterized by containing two or more electrical generation technologies, in order to optimize the global efficiency of the processes involved. These systems can present different operating modes. Besides, they take into account aspects that not only concern the electrical and thermal efficiencies, but also the reduction of pollutant emissions. There is a wide range of possible configurations to form hybrid systems, including hydrogen, renewable energies, gas cycles, vapour cycles or both. Nowadays, these technologies are mainly used for energy production in electrical microgrids. Some examples of these technologies are: hybridization processes of fuel cells with wind turbines and photovoltaic plants, cogeneration and trigeneration processes that can be configured with fuel cell technologies, etc. This paper reviews and analyses the main characteristics of electrical microgrids and the systems based on fuel cells for polygeneration and hybridization processes. (author)

  17. Technology of mammalian cell encapsulation

    NARCIS (Netherlands)

    Uludag, H; De Vos, P; Tresco, PA

    2000-01-01

    Entrapment of mammalian cells in physical membranes has been practiced since the early 1950s when it was originally introduced as a basic research tool. The method has since been developed based on the promise of its therapeutic usefulness in tissue transplantation. Encapsulation physically isolates

  18. Technology advancement for integrative stem cell analyses.

    Science.gov (United States)

    Jeong, Yoon; Choi, Jonghoon; Lee, Kwan Hyi

    2014-12-01

    Scientists have endeavored to use stem cells for a variety of applications ranging from basic science research to translational medicine. Population-based characterization of such stem cells, while providing an important foundation to further development, often disregard the heterogeneity inherent among individual constituents within a given population. The population-based analysis and characterization of stem cells and the problems associated with such a blanket approach only underscore the need for the development of new analytical technology. In this article, we review current stem cell analytical technologies, along with the advantages and disadvantages of each, followed by applications of these technologies in the field of stem cells. Furthermore, while recent advances in micro/nano technology have led to a growth in the stem cell analytical field, underlying architectural concepts allow only for a vertical analytical approach, in which different desirable parameters are obtained from multiple individual experiments and there are many technical challenges that limit vertically integrated analytical tools. Therefore, we propose--by introducing a concept of vertical and horizontal approach--that there is the need of adequate methods to the integration of information, such that multiple descriptive parameters from a stem cell can be obtained from a single experiment.

  19. Education Technology Standards Self-Efficacy (ETSSE) Scale: A Validity and Reliability Study

    Science.gov (United States)

    Simsek, Omer; Yazar, Taha

    2016-01-01

    Problem Statement: The educational technology standards for teachers set by the International Society for Technology in Education (the ISTE Standards-T) represent an important framework for using technology effectively in teaching and learning processes. These standards are widely used by universities, educational institutions, and schools. The…

  20. 75 FR 62686 - Health Information Technology: Revisions to Initial Set of Standards, Implementation...

    Science.gov (United States)

    2010-10-13

    ... Health Information Technology: Revisions to Initial Set of Standards, Implementation Specifications, and... Health Information Technology (ONC), Department of Health and Human Services. ACTION: Interim final rule... Coordinator for Health Information Technology, Attention: Steven Posnack, Hubert H. Humphrey Building, Suite...

  1. 75 FR 32472 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-06-08

    ... Coordinator for Health Information Technology AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of committee recommendations and invitation for public input... Coordinator for Health Information Technology (ONC). Name of Committee: HIT Standards Committee. General...

  2. 77 FR 54163 - Health Information Technology: Standards, Implementation Specifications, and Certification...

    Science.gov (United States)

    2012-09-04

    ... Health Information Technology: Standards, Implementation Specifications, and Certification Criteria for... Health Information Technology AGENCY: Office of the National Coordinator for Health Information... information technology, including changing the program's name to the ONC HIT Certification Program. DATES...

  3. Seventy Years of Radio Science, Technology, Standards, and Measurement at the National Bureau of Standards

    Science.gov (United States)

    Gillmor, C. Stewart

    This large volume describes all the forms of radio research done at the National Bureau of Standards (now, National Institute of Standards and Technology) from its founding in 1901 until about 1980. The volume truly reflects its subtitle; it describes in great detail research in radio propagation and all its connections with geophysics and geospace, but also radio as instrument for discovery and application in meteorology, navigation, and in standards of measurement and testing in electronics.The book is a bit unwieldy and some of its chapters will be of most interest to former NBS employees. For example, there is a lengthy chapter on the transfer of radio research work from Washington, D.C, to Boulder, Colo., in the early 1950s, complete with photostat of the quit claim deed to NBS from the Boulder Chamber of Commerce. On the other hand, radio research developed and flourished in this country in the early days at industrial (Bell Telephone, General Electric, Westinghouse) and government (NBS, Naval Research Laboratory) labs more than in academia, and it is very interesting to learn how the labs interacted and to read details of the organizational structure. I can attest personally to the great difficulties in locating materials concerning radio history. While we have numerous volumes devoted to certain popular radio heroes, little is available concerning government radio pioneers such as L. W. Austin, who directed the U.S. Navy's radio research for many years while situated physically at the Bureau of Standards, or J. H. Dellinger, long-time chief of the Radio Section and head spokesman on radio for the U.S. government until the 1930s.

  4. Keeping up with Our Students: The Evolution of Technology and Standards in Art Education

    Science.gov (United States)

    Patton, Ryan M.; Buffington, Melanie L.

    2016-01-01

    This article addresses the standards of technology in the visual arts, arguing the standards function as de facto policy, the guidelines that shape what teachers teach. In this study, we investigate how art education standards approach technology as a teaching tool and artmaking medium, analyzing the current National Visual Arts Standards, the…

  5. HTGR technology development in Japan advances so much. Leading world technology to global standards

    International Nuclear Information System (INIS)

    Ogawa, Masuro; Hino, Ryutaro; Kunitomi, Kazuhiko; Onuki, Kaoru; Inagaki, Yoshiyuki; Takeda, Tetsuaki; Sawa, Kazuhiro

    2007-01-01

    The JAEA has conducted research and development of HTGR for hydrogen production since 1969 and attained the operation of 950degC at reactor coolant outlet of the HTTR in 2004. This article describes present status and future plan of R and D in the area of HTGR technology and high temperature heat utilization and also introduces the design of the commercial HTGR cogeneration system based on R and D results leading to world standards. (T. Tanaka)

  6. An Overview of Stationary Fuel Cell Technology

    Energy Technology Data Exchange (ETDEWEB)

    DR Brown; R Jones

    1999-03-23

    Technology developments occurring in the past few years have resulted in the initial commercialization of phosphoric acid (PA) fuel cells. Ongoing research and development (R and D) promises further improvement in PA fuel cell technology, as well as the development of proton exchange membrane (PEM), molten carbonate (MC), and solid oxide (SO) fuel cell technologies. In the long run, this collection of fuel cell options will be able to serve a wide range of electric power and cogeneration applications. A fuel cell converts the chemical energy of a fuel into electrical energy without the use of a thermal cycle or rotating equipment. In contrast, most electrical generating devices (e.g., steam and gas turbine cycles, reciprocating engines) first convert chemical energy into thermal energy and then mechanical energy before finally generating electricity. Like a battery, a fuel cell is an electrochemical device, but there are important differences. Batteries store chemical energy and convert it into electrical energy on demand, until the chemical energy has been depleted. Depleted secondary batteries may be recharged by applying an external power source, while depleted primary batteries must be replaced. Fuel cells, on the other hand, will operate continuously, as long as they are externally supplied with a fuel and an oxidant.

  7. 2008 Fuel Cell Technologies Market Report

    Energy Technology Data Exchange (ETDEWEB)

    DOE

    2010-06-01

    Fuel cells are electrochemical devices that combine hydrogen and oxygen to produce electricity, water, and heat. Unlike batteries, fuel cells continuously generate electricity, as long as a source of fuel is supplied. Moreover, fuel cells do not burn fuel, making the process quiet, pollution-free and two to three times more efficient than combustion. Fuel cell systems can be a truly zero-emission source of electricity, if the hydrogen is produced from non-polluting sources. Global concerns about climate change, energy security, and air pollution are driving demand for fuel cell technology. More than 630 companies and laboratories in the United States are investing $1 billion a year in fuel cells or fuel cell component technologies. This report provides an overview of trends in the fuel cell industry and markets, including product shipments, market development, and corporate performance. It also provides snapshots of select fuel cell companies, including general business strategy and market focus, as well as, financial information for select publicly-traded companies.

  8. 2008 Fuel Cell Technologies Market Report

    Energy Technology Data Exchange (ETDEWEB)

    Vincent, B. [Breakthrough Technologies Inst., Washington, DC (United States)

    2010-06-30

    Fuel cells are electrochemical devices that combine hydrogen and oxygen to produce electricity, water, and heat. Unlike batteries, fuel cells continuously generate electricity, as long as a source of fuel is supplied. Moreover, fuel cells do not burn fuel, making the process quiet, pollution-free and two to three times more efficient than combustion. Fuel cell systems can be a truly zero-emission source of electricity, if the hydrogen is produced from non-polluting sources. Global concerns about climate change, energy security, and air pollution are driving demand for fuel cell technology. More than 630 companies and laboratories in the United States are investing $1 billion a year in fuel cells or fuel cell component technologies. This report provides an overview of trends in the fuel cell industry and markets, including product shipments, market development, and corporate performance. It also provides snapshots of select fuel cell companies, including general business strategy and market focus, as well as, financial information for select publicly-traded companies.

  9. Acceleration of cell factories engineering using CRISPR-based technologies

    DEFF Research Database (Denmark)

    Ronda, Carlotta

    potentially be standardized in an automatable platform and, in the future be integrated with metabolic modeling tools. In particularly it describes the technologies developed in the three widely used organisms: E. coli, S. cerevisiae and CHO mammalian cells using the recent breakthrough CRISPR/ Cas9 system....... These include CRMAGE, a MAGE improved recombineering platform using CRISPR negative selection, CrEdit, a system for multi-loci marker-free simultaneous gene and pathway integrations and CRISPy a platform to accelerate genome editing in CHO cells....

  10. Single-cell technologies in environmental omics

    KAUST Repository

    Kodzius, Rimantas; Gojobori, Takashi

    2015-01-01

    Environmental studies are primarily done by culturing isolated microorganisms or by amplifying and sequencing conserved genes. Difficulties understanding the complexity of large numbers of various microorganisms in an environment led to the development of techniques to enrich specific microorganisms for upstream analysis, ultimately leading to single-cell isolation and analyses. We discuss the significance of single-cell technologies in omics studies with focus on metagenomics and metatranscriptomics. We propose that by reducing sample heterogeneity using single-cell genomics, metaomic studies can be simplified.

  11. Single-cell technologies in environmental omics

    KAUST Repository

    Kodzius, Rimantas

    2015-10-22

    Environmental studies are primarily done by culturing isolated microorganisms or by amplifying and sequencing conserved genes. Difficulties understanding the complexity of large numbers of various microorganisms in an environment led to the development of techniques to enrich specific microorganisms for upstream analysis, ultimately leading to single-cell isolation and analyses. We discuss the significance of single-cell technologies in omics studies with focus on metagenomics and metatranscriptomics. We propose that by reducing sample heterogeneity using single-cell genomics, metaomic studies can be simplified.

  12. Development of solid oxide fuel cell technology

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Dae Kab; Kim, Sun Jae; Jung, Choong Hwan; Kim, Kyung Hoh; Park, Ji Yun; Oh, Suk Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-01-01

    Solid Oxide Fuel Cell (SOFC) technologies that use zirconium oxide as the electrolyte material were studied in this present report. SOFC exhibits a very high power generation efficiency of over 50 %, and does not discharge pollution materials such as dusts, sulfur dioxide, and nitrogen oxide. Zirconia, Ni/YSZ (yttria stabilized zirconia), and La-Sr-Mn-Oxide materials were developed for the electrolyte material, for the anode, and for the cathode, respectively. After making thin zirconia plate using tape casting process, anode and cathode powders were screen printed on the zirconia plate for fabricating unit cells. A test system composed of a vertical tube furnace, digital multimeter, DC current supplier, and measuring circuit was constructed for testing the unit cell performance. This system was controlled by a home-made computer program. Founded on this unit cell technology and system, a multi-stack SOFC system was studied. This system was composed of 10 unit cells each of them had an electrode area of 40 x 40 mm. Based on this system design, large and thin zirconia plates of 70 x 70 mm in area was fabricated for the electrolyte. Different from in the unit cell system, interconnectors are needed in the multi-stack system for connecting unit cells electrically. For this interconnectors, Inconel 750 alloy was selected, sliced into wafers, machined, surface finished, and then Pt-plated. 55 figs, 8 tabs, 51 refs. (Author).

  13. Development of solid oxide fuel cell technology

    International Nuclear Information System (INIS)

    Kang, Dae Kab; Kim, Sun Jae; Jung, Choong Hwan; Kim, Kyung Hoh; Park, Ji Yun; Oh, Suk Jin

    1995-01-01

    Solid Oxide Fuel Cell (SOFC) technologies that use zirconium oxide as the electrolyte material were studied in this present report. SOFC exhibits a very high power generation efficiency of over 50 %, and does not discharge pollution materials such as dusts, sulfur dioxide, and nitrogen oxide. Zirconia, Ni/YSZ (yttria stabilized zirconia), and La-Sr-Mn-Oxide materials were developed for the electrolyte material, for the anode, and for the cathode, respectively. After making thin zirconia plate using tape casting process, anode and cathode powders were screen printed on the zirconia plate for fabricating unit cells. A test system composed of a vertical tube furnace, digital multimeter, DC current supplier, and measuring circuit was constructed for testing the unit cell performance. This system was controlled by a home-made computer program. Founded on this unit cell technology and system, a multi-stack SOFC system was studied. This system was composed of 10 unit cells each of them had an electrode area of 40 x 40 mm. Based on this system design, large and thin zirconia plates of 70 x 70 mm in area was fabricated for the electrolyte. Different from in the unit cell system, interconnectors are needed in the multi-stack system for connecting unit cells electrically. For this interconnectors, Inconel 750 alloy was selected, sliced into wafers, machined, surface finished, and then Pt-plated. 55 figs, 8 tabs, 51 refs. (Author)

  14. Photovoltaic-cell technologies joust for position

    Science.gov (United States)

    Fischetti, M. A.

    1984-03-01

    The three most promising photovoltaic cell technologies, single-crystal-silicon cells, polycrystalline thin films, and amorphous silicon thin films, are reviewed and discussed in terms of present levels of applicability and the prospects for domination of PV markets in the future. A U.S. DOE research plan running from 1984 to 1988 which aims to produce PV modules that will generate electricity at $.20/kWh by 1988 is outlined, and R & D efforts in Japan and Europe are considered. Although GaAs cells have reached efficiencies to 20 percent in the laboratory, the most successful commercial products have been single-crystal-silicon cells with efficiencies between 11 and 12 percent. It is suggested that the immiment rise of amorphous silicon in the late 1980s may thwart polycrystalline-cell development before it has a chance to flourish.

  15. Chapter 6. Operation of electrolytic cell in standard operating practices

    International Nuclear Information System (INIS)

    Yanko, E.A.; Kabirov, Sh.O.; Safiev, Kh.; Azizov, B.S.; Mirpochaev, Kh.A.

    2011-01-01

    This chapter is devoted to operation of electrolytic cell in standard operating practices. Therefore, the electrolyte temperature, the composition of electrolyte, including the level of metals was considered. The regulation of electrolyte composition by liquidus temperature and electrolyte overheating was studied. Damping of anode effects was studied as well. Maintenance of electrolytic cells was described. Heat and energy balances of aluminium electrolytic cells were considered.

  16. 76 FR 1432 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2011-01-10

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of Meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  17. 75 FR 8954 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-02-26

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  18. 75 FR 70923 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-11-19

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  19. 75 FR 29761 - Office of the National Coordinator for Health Information Technology: HIT Standards Committee...

    Science.gov (United States)

    2010-05-27

    ... Technology: HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  20. 76 FR 4354 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2011-01-25

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards...

  1. 45 CFR 170.210 - Standards for health information technology to protect electronic health information created...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Standards for health information technology to... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION... FOR HEALTH INFORMATION TECHNOLOGY Standards and Implementation Specifications for Health Information...

  2. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 810 (FEREX Fluxgate Gradient Magnetometer/Sling)

    National Research Council Canada - National Science Library

    Fling, Rick; McClung, Christina; Banta, Matthew; Burch, William; Karwatka, Michael; McDonnell, Patrick

    2007-01-01

    ...) utilizing the APG Standardized UXO Technology Demonstration Site Blind Grid. This Scoring Record was coordinated by Michael Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

  3. Standardized UXO Technology Demonstration Site, Open Field Scoring Record No. 770. Magnetometer FEREX DLG GPS/Sling

    National Research Council Canada - National Science Library

    Karwatka, Mike; Packer, Bonnie

    2006-01-01

    ...) utilizing the YPG Standardized UXO Technology Demonstration Site open field. Scoring Records have been coordinated by Mike Karwatka and the Standardized UXO Technology Demonstration Site Scoring Committee...

  4. The Economics of Standards and Standardization in Information and Communication Technologies

    DEFF Research Database (Denmark)

    Pedersen, Mogens Kuhn; Fomin, Vladislav V.

    2006-01-01

    processes in the field of ICT taking place? How and why do open standards differ from other types of standards? How may open standards influence ICT government policy and the reverse: How will government need to take action in the face of the international trend toward open standards in ICT?...

  5. Modern standardization case studies at the crossroads of technology, economics, and politics

    CERN Document Server

    Schneiderman, R

    2015-01-01

    Modern Standardization -- Case Studies at the Crossroads of Technology, Economics, and Politics covers the development of new technical standards, how these standards are typically triggered, and how they are submitted to standards development organizations (SDOs) for review and evaluation. It fills the gap in the shortage of reference material in the development of real-world standards. The increasing pace of innovation in technology has accelerated the competitive nature of standardization, particularly in emerging markets. Modern Standardization addresses these and other issues through a series of case studies in a format designed for academics and their engineering, business, and law school students.

  6. Medical Device Plug-and-Play Interoperability Standards and Technology Leadership

    Science.gov (United States)

    2017-10-01

    Award Number: W81XWH-09-1-0705 TITLE: “Medical Device Plug-and-Play Interoperability Standards and Technology Leadership” PRINCIPAL INVESTIGATOR...Sept 2016 – 20 Sept 2017 4. TITLE AND SUBTITLE “Medical Device Plug-and-Play Interoperability 5a. CONTRACT NUMBER Standards and Technology ...efficiency through interoperable medical technologies . We played a leadership role on interoperability safety standards (AAMI, AAMI/UL Joint

  7. DOD Information Technology Standard Guidance (ITSG) Version 3.1

    Science.gov (United States)

    1997-04-07

    Survey USL Unix Systems Labs USMTF United States Message Text Format USS Uniform Symbology Specification UUCP Unix-to-Unix Copy Protocol VDI Virtual...h. VDI (Virtual Device Interface) 3.5.6.3.3 Standards deficiencies. The COM standards have limited capabilities for handling 3-D geometries...not expected to be included in the proposed standard. Project 1158-D also allows for three sector sizes, 512, 1024, and 2048 bytes per sector. f. ANSI

  8. Standards application and development plan for solar thermal technologies

    Science.gov (United States)

    Cobb, H. R. W.

    1981-07-01

    Functional and standards matrices, developed from input from ST users and from the industry that will be continually reviewed and updated as commercial aspects develop are presented. The matrices highlight codes, standards, test methods, functions and definitions that need to be developed. They will be submitted through ANSI for development by national consensus bodies. A contingency action is proposed for standards development if specific input is lacking at the committee level or if early development of a standard would hasten commercialization or gain needed jurisdictional acceptance.

  9. Benefits of on-wafer calibration standards fabricated in membrane technology

    Science.gov (United States)

    Rohland, M.; Arz, U.; Büttgenbach, S.

    2011-07-01

    In this work we compare on-wafer calibration standards fabricated in membrane technology with standards built in conventional thin-film technology. We perform this comparison by investigating the propagation of uncertainties in the geometry and material properties to the broadband electrical properties of the standards. For coplanar waveguides used as line standards the analysis based on Monte Carlo simulations demonstrates an up to tenfold reduction in uncertainty depending on the electromagnetic waveguide property we look at.

  10. Standardized and Repeatable Technology Evaluation for Cybersecurity Acquisition

    Science.gov (United States)

    2017-02-01

    financial benefit for adopting a cybersecurity technology. 2.2 TECHNOLOGY SELECTION Often organizations will adopt frameworks (e.g., NIST, ISO - 27000 , or...security managers. Many organizations use the NIST1, ISO -270002, or COBIT frameworks3, but for smaller organizations, these frameworks can be overly

  11. Creating transient cell membrane pores using a standard inkjet printer.

    Science.gov (United States)

    Owczarczak, Alexander B; Shuford, Stephen O; Wood, Scott T; Deitch, Sandra; Dean, Delphine

    2012-03-16

    Bioprinting has a wide range of applications and significance, including tissue engineering, direct cell application therapies, and biosensor microfabrication. Recently, thermal inkjet printing has also been used for gene transfection. The thermal inkjet printing process was shown to temporarily disrupt the cell membranes without affecting cell viability. The transient pores in the membrane can be used to introduce molecules, which would otherwise be too large to pass through the membrane, into the cell cytoplasm. The application being demonstrated here is the use of thermal inkjet printing for the incorporation of fluorescently labeled g-actin monomers into cells. The advantage of using thermal ink-jet printing to inject molecules into cells is that the technique is relatively benign to cells. Cell viability after printing has been shown to be similar to standard cell plating methods. In addition, inkjet printing can process thousands of cells in minutes, which is much faster than manual microinjection. The pores created by printing have been shown to close within about two hours. However, there is a limit to the size of the pore created (~10 nm) with this printing technique, which limits the technique to injecting cells with small proteins and/or particles. A standard HP DeskJet 500 printer was modified to allow for cell printing. The cover of the printer was removed and the paper feed mechanism was bypassed using a mechanical lever. A stage was created to allow for placement of microscope slides and coverslips directly under the print head. Ink cartridges were opened, the ink was removed and they were cleaned prior to use with cells. The printing pattern was created using standard drawing software, which then controlled the printer through a simple print command. 3T3 fibroblasts were grown to confluence, trypsinized, and then resuspended into phosphate buffered saline with soluble fluorescently labeled g-actin monomers. The cell suspension was pipetted into the

  12. Thin film solar cell technology in Germany

    International Nuclear Information System (INIS)

    Diehl, W.; Sittinger, V.; Szyszka, B.

    2005-01-01

    Within the scope of limited nonrenewable energy resources and the limited capacity of the ecosystem for greenhouse gases and nuclear waste, sustainability is one important target in the future. Different energy scenarios showed the huge potential for photovoltaics (PV) to solve this energy problem. Nevertheless, in the last decade, PV had an average growth rate of over 20% per year. In 2002, the solar industry delivered more than 500 MWp/year of photovoltaic generators [A. Jaeger-Waldau, A European Roadmap for PV R and D, E-MRS Spring Meeting, (2003)]. More than 85% of the current production involves crystalline silicon technologies. These technologies still have a high cost reduction potential, but this will be limited by the silicon feedstock. On the other hand the so-called second generation thin film solar cells based on a-Si, Cu(In,Ga)(Se,S 2 (CIGS) or CdTe have material thicknesses of a few microns as a result of their direct band gap. Also, the possibility of circuit integration offers an additional cost reduction potential. Especially in Germany, there are a few companies who focus on thin film solar cells. Today, there are two manufacturers with production lines: the Phototronics (PST) division of RWE-Schott Solar with a-Si thin film technology and the former Antec Solar GmbH (now Antec Solar Energy GmbH) featuring the CdTe technology. A pilot line based on CIGS technology is run by Wuerth Solar GmbH. There is also a variety of research activity at other companies, namely, at Shell Solar, Sulfurcell Solartechnik GmbH, Solarion GmbH and the CIS-Solartechnik GmbH. We will give an overview on research activity on various thin film technologies, as well as different manufacturing and production processes in the companies mentioned above. (Author)

  13. Standard practice for cell sorting in a BSL-3 facility.

    Science.gov (United States)

    Perfetto, Stephen P; Ambrozak, David R; Nguyen, Richard; Roederer, Mario; Koup, Richard A; Holmes, Kevin L

    2011-01-01

    Over the past decade, there has been a rapid growth in the number of BSL-3 and BSL-4 laboratories in the USA and an increase in demand for infectious cell sorting in BSL-3 laboratories. In 2007, the International Society for Advancement of Cytometry (ISAC) Biosafety Committee published standards for the sorting of unfixed cells and is an important resource for biosafety procedures when performing infectious cell sorting. Following a careful risk assessment, if it is determined that a cell sorter must be located within a BSL-3 laboratory, there are a variety of factors to be considered prior to the establishment of the laboratory. This chapter outlines procedures for infectious cell sorting in a BSL-3 environment to facilitate the establishment and safe operation of a BSL-3 cell sorting laboratory. Subjects covered include containment verification, remote operation, disinfection, personal protective equipment (PPE), and instrument-specific modifications for enhanced aerosol evacuation.

  14. 78 FR 23574 - Public Workshop on Marine Technology and Standards

    Science.gov (United States)

    2013-04-19

    ... Procedure for Marine Tubular Grooved Pipe Joints in Shipboard Applications Compressed Natural Gas (CNG... Dynamic Positioning Software Testing and Validation Development of Autonomous Underwater Platforms for... opportunity for classification societies, industry groups, standards development organizations, government...

  15. Comparison of current practices of cardiopulmonary perfusion technology in Iran with American Society of Extracorporeal Technology's standards.

    Science.gov (United States)

    Faravan, Amir; Mohammadi, Nooredin; Alizadeh Ghavidel, Alireza; Toutounchi, Mohammad Zia; Ghanbari, Ameneh; Mazloomi, Mehran

    2016-01-01

    Standards have a significant role in showing the minimum level of optimal optimum and the expected performance. Since the perfusion technology staffs play an the leading role in providing the quality services to the patients undergoing open heart surgery with cardiopulmonary bypass machine, this study aimed to assess the standards on how Iranian perfusion technology staffs evaluate and manage the patients during the cardiopulmonary bypass process and compare their practice with the recommended standards by American Society of Extracorporeal Technology. In this descriptive study, data was collected from 48 Iranian public hospitals and educational health centers through a researcher-created questionnaire. The data collection questionnaire assessed the standards which are recommended by American Society of Extracorporeal Technology. Findings showed that appropriate measurements were carried out by the perfusion technology staffs to prevent the hemodilution and avoid the blood transfusion and unnecessary blood products, determine the initial dose of heparin based on one of the proposed methods, monitor the anticoagulants based on ACT measurement, and determine the additional doses of heparin during the cardiopulmonary bypass based on ACT or protamine titration. It was done only in 4.2% of hospitals and health centers. Current practices of cardiopulmonary perfusion technology in Iran are inappropriate based on the standards of American Society of Cardiovascular Perfusion. This represents the necessity of authorities' attention to the validation programs and development of the caring standards on one hand and continuous assessment of using these standards on the other hand.

  16. 75 FR 65636 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-10-26

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  17. 75 FR 57027 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-09-17

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  18. 75 FR 42090 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-07-20

    ... Technology; HIT Standards Committee Advisory Meeting; Notice of Meeting AGENCY: Office of the National... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Strategic Plan, and in accordance with policies developed by the HIT Policy Committee. Date and Time: The...

  19. 40 CFR 450.24 - New source performance standards reflecting the best available demonstrated control technology...

    Science.gov (United States)

    2010-07-01

    ... performance standards reflecting the best available demonstrated control technology (NSPS). Any new source... 40 Protection of Environment 29 2010-07-01 2010-07-01 false New source performance standards reflecting the best available demonstrated control technology (NSPS). 450.24 Section 450.24 Protection of...

  20. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-08-01

    This report identifies the commercial and near-commercial (emerging) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies Program in the Office of Energy Efficiency and Renewable Energy.

  1. Reviews on Solid Oxide Fuel Cell Technology

    Directory of Open Access Journals (Sweden)

    Apinan Soottitantawat

    2009-02-01

    Full Text Available Solid Oxide Fuel Cell (SOFC is one type of high temperature fuel cell that appears to be one of the most promising technology to provide the efficient and clean energy production for wide range of applications (from small units to large scale power plants. This paper reviews the current status and related researches on SOFC technologies. In details, the research trend for the development of SOFC components(i.e. anode, electrolyte, cathode, and interconnect are presented. Later, the current important designs of SOFC (i.e. Seal-less Tubular Design, Segmented Cell in Series Design, Monolithic Design and Flat Plate Design are exampled. In addition, the possible operations of SOFC (i.e. external reforming, indirect internal reforming, and direct internal reforming are discussed. Lastly, the research studies on applications of SOFCs with co-generation (i.e. SOFC with Combined Heat and Power (SOFC-CHP, SOFC with Gas Turbine (SOFC-GT and SOFC with chemical production are given.

  2. 77 FR 55482 - Public Workshop on Marine Technology and Standards

    Science.gov (United States)

    2012-09-10

    ... controls Human Element Human factors engineering Safety management systems Human and controls interface... professional exchange of information on topics ranging from technological impacts on the marine industry..., 2012. See SUPPLEMENTARY INFORMATION below for other dates related to submission of abstracts, draft...

  3. 75 FR 8099 - Public Workshop on Marine Technology and Standards

    Science.gov (United States)

    2010-02-23

    ... Ship/Emerging Technology Maintenance and Inservice Inspection Regulatory/Classification/Governmental... this notice is available for inspection or copying at the Docket Management Facility (M-30), U.S... construction of ships and shipboard equipment, including hull structure, stability, electrical & mechanical...

  4. Technology standards and increasing returns: Microsoft versus Nokia and Linux

    NARCIS (Netherlands)

    Millar-Schijf, Carla C.J.M.; Millar, P.H.; Choi, C.J.

    2010-01-01

    The purpose of this article is to advance theory on the concept of increasing returns by reviewing different strands of literature (Arthur, 1994; Liebowitz and Margolis, 1990; 1994; David, 1990) and to develop the concept of a 'critical mass' strategy which incorporates both technological effects

  5. Strategic technology policy as a supplement to renewable energy standards

    NARCIS (Netherlands)

    Fischer, Carolyn; Greaker, Mads; Rosendahl, Knut Einar

    2018-01-01

    In many regions, renewable energy targets are a primary decarbonization policy. Most of the same jurisdictions also subsidize the manufacturing and/or deployment of renewable energy technologies, some being sufficiently aggressive as to engender WTO disputes. We consider a downstream energy-using

  6. 75 FR 51818 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-08-23

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  7. 75 FR 65486 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-10-25

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  8. 75 FR 57025 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-09-17

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  9. 75 FR 8079 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-02-23

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  10. 76 FR 4353 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2011-01-25

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  11. 75 FR 12753 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-03-17

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  12. 75 FR 36657 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-06-28

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  13. 76 FR 1433 - Office of the National Coordinator for Health Information Technology HIT Standards Committee's...

    Science.gov (United States)

    2011-01-10

    ... Technology HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  14. 75 FR 70925 - Office of the National Coordinator for Health Information Technology; HIT; Standards Committee's...

    Science.gov (United States)

    2010-11-19

    ... Technology; HIT; Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  15. 75 FR 29761 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-05-27

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  16. 75 FR 368 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-01-05

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  17. 75 FR 3905 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee's...

    Science.gov (United States)

    2010-01-25

    ... Technology; HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice of meetings. This notice announces... for Health Information Technology (ONC). The meetings will be open to the public via dial-in access...

  18. 78 FR 76627 - Health Information Technology Standards Committee Advisory Meeting: Notice of Meeting

    Science.gov (United States)

    2013-12-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Information Technology Standards Committee Advisory Meeting: Notice of Meeting AGENCY: Office of the National Coordinator for Health Information Technology... committee of the Office of the National Coordinator for Health Information Technology (ONC). These meeting...

  19. 75 FR 16126 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-03-31

    ... Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... and Coordination, Office of the National Coordinator for Health Information Technology. [FR Doc. 2010...

  20. 75 FR 44589 - Health Information Technology: Initial Set of Standards, Implementation Specifications, and...

    Science.gov (United States)

    2010-07-28

    ... Part III Department of Health and Human Services 45 CFR Part 170 Health Information Technology... Secretary 45 CFR Part 170 RIN 0991-AB58 Health Information Technology: Initial Set of Standards... of the National Coordinator for Health Information Technology (ONC), Department of Health and Human...

  1. 25 CFR 542.16 - What are the minimum internal control standards for information technology?

    Science.gov (United States)

    2010-04-01

    ... information technology? 542.16 Section 542.16 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE... standards for information technology? Link to an amendment published at 73 FR 60498, Oct. 10, 2008. This... adequately segregated and monitored to prevent error in general information technology procedures to go...

  2. 75 FR 151 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-01-04

    ... Coordinator for Health Information Technology, HHS. ACTION: Notice of meeting. This notice announces a... Information Technology (ONC). The meeting will be open to the public. Name of Committee: HIT Standards... Programs and Coordination Office of the National Coordinator for Health Information Technology. [FR Doc. E9...

  3. Acceptance Factors Influencing Adoption of National Institute of Standards and Technology Information Security Standards: A Quantitative Study

    Science.gov (United States)

    Kiriakou, Charles M.

    2012-01-01

    Adoption of a comprehensive information security governance model and security controls is the best option organizations may have to protect their information assets and comply with regulatory requirements. Understanding acceptance factors of the National Institute of Standards and Technology (NIST) Risk Management Framework (RMF) comprehensive…

  4. CANDIED PUMPKIN; TECHNOLOGY FOR ITS PREPARATION AND STANDARD FOR ORGANIZATION

    OpenAIRE

    L. V. Pavlov; N. A. Golubkina; L. M. Shilo; E. V. Baranova; G. A. Khimich

    2017-01-01

    Standard for organization for candied pumpkin has been developed. Industrial raw material. The following ‘Technical Specifications’ included: definitions, terms, abbreviations, technical requirements, orders of reception, trial methods, transportation and storage, labor protection, fire security and reference list. The product is pumpkin pulp cut to pieces of different shapes and sizes boiled in sugar syrup, dried and coated with granulated sugar. Fruits of pumpkin that need for production ar...

  5. Sliver Solar Cells: High-Efficiency, Low-Cost PV Technology

    Directory of Open Access Journals (Sweden)

    Evan Franklin

    2007-01-01

    Full Text Available Sliver cells are thin, single-crystal silicon solar cells fabricated using standard fabrication technology. Sliver modules, composed of several thousand individual Sliver cells, can be efficient, low-cost, bifacial, transparent, flexible, shadow tolerant, and lightweight. Compared with current PV technology, mature Sliver technology will need 10% of the pure silicon and fewer than 5% of the wafer starts per MW of factory output. This paper deals with two distinct challenges related to Sliver cell and Sliver module production: providing a mature and robust Sliver cell fabrication method which produces a high yield of highly efficient Sliver cells, and which is suitable for transfer to industry; and, handling, electrically interconnecting, and encapsulating billions of sliver cells at low cost. Sliver cells with efficiencies of 20% have been fabricated at ANU using a reliable, optimised processing sequence, while low-cost encapsulation methods have been demonstrated using a submodule technique.

  6. RE/H2 Production Micro-System Based on Standard Alkaline Electrolytic Technology

    International Nuclear Information System (INIS)

    Moschetto, A.; Tina, G.M.; Ferraro, M.; Briguglio, N.; Antonucci, V.

    2006-01-01

    This paper presents the first task of a more comprehensive research project focused on the development of micro-scale (1-20 kW) Renewable Hydrogen (RE/H 2 ) production systems oriented to carry on a wide campaign of educational and demonstration projects. The paper proposes to rely on low-cost and rugged 'standard' alkaline electrolytic technology, well suited for decentralized hydrogen production, but requiring a certain R and D effort to get technical competitiveness. An electrolyser test facility has been designed and carried out. Then performance assessment of a commercial electrolyser and its sub-systems has been accomplished. First experimental results stated that the unit under test gets an average production efficiency of 51%, versus a stack (cell) efficiency of about 62%, while the aged AC/DC power converter, to be removed or replaced to adapt the unit to DC link with renewables, requires more than 16% of the incoming power. (authors)

  7. RE/H{sub 2} Production Micro-System Based on Standard Alkaline Electrolytic Technology

    Energy Technology Data Exchange (ETDEWEB)

    Moschetto, A.; Tina, G.M. [UNICT DIEES University of Catania - Electric, Electronic and Systemcs Department, Viale A. Doria, 5 - 95125 Catania, (Italy); Ferraro, M.; Briguglio, N.; Antonucci, V. [CNR ITAE, National Council of Research - Advanced Energy Technology Institute, Via Salita S. Lucia, 5 - 98128 Messina, (Italy)

    2006-07-01

    This paper presents the first task of a more comprehensive research project focused on the development of micro-scale (1-20 kW) Renewable Hydrogen (RE/H{sub 2}) production systems oriented to carry on a wide campaign of educational and demonstration projects. The paper proposes to rely on low-cost and rugged 'standard' alkaline electrolytic technology, well suited for decentralized hydrogen production, but requiring a certain R and D effort to get technical competitiveness. An electrolyser test facility has been designed and carried out. Then performance assessment of a commercial electrolyser and its sub-systems has been accomplished. First experimental results stated that the unit under test gets an average production efficiency of 51%, versus a stack (cell) efficiency of about 62%, while the aged AC/DC power converter, to be removed or replaced to adapt the unit to DC link with renewables, requires more than 16% of the incoming power. (authors)

  8. Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity

    Directory of Open Access Journals (Sweden)

    Alessandra M. Welker

    2016-02-01

    Full Text Available Glioblastoma (GBM is a deadly brain cancer, for which few effective drug treatments are available. Several studies have used zebrafish models to study GBM, but a standardized approach to modeling GBM in zebrafish was lacking to date, preventing comparison of data across studies. Here, we describe a new, standardized orthotopic xenotransplant model of GBM in zebrafish. Dose-response survival assays were used to define the optimal number of cells for tumor formation. Techniques to measure tumor burden and cell spread within the brain over real time were optimized using mouse neural stem cells as control transplants. Applying this standardized approach, we transplanted two patient-derived GBM cell lines, serum-grown adherent cells and neurospheres, into the midbrain region of embryonic zebrafish and analyzed transplanted larvae over time. Progressive brain tumor growth and premature larval death were observed using both cell lines; however, fewer transplanted neurosphere cells were needed for tumor growth and lethality. Tumors were heterogeneous, containing both cells expressing stem cell markers and cells expressing markers of differentiation. A small proportion of transplanted neurosphere cells expressed glial fibrillary acidic protein (GFAP or vimentin, markers of more differentiated cells, but this number increased significantly during tumor growth, indicating that these cells undergo differentiation in vivo. By contrast, most serum-grown adherent cells expressed GFAP and vimentin at the earliest times examined post-transplant. Both cell types produced brain tumors that contained Sox2+ cells, indicative of tumor stem cells. Transplanted larvae were treated with currently used GBM therapeutics, temozolomide or bortezomib, and this resulted in a reduction in tumor volume in vivo and an increase in survival. The standardized model reported here facilitates robust and reproducible analysis of glioblastoma tumor cells in real time and provides a

  9. Electronic Document Delivery: Converging Standards and Technologies. UDT Series on Data Communication Technologies and Standards for Libraries, Report #2.

    Science.gov (United States)

    Cleveland, Gary

    The development of information technologies such as public access catalogs and online databases has greatly enhanced access to information. The lack of automation in the area of document delivery, however, has created a large disparity between the speed with which citations are found and the provision of primary documents. This imbalance can…

  10. Aspiring School Administrators' Perceived Ability to Meet Technology Standards and Technological Needs for Professional Development

    Science.gov (United States)

    Yu, Chien; Prince, Debra Lindsey

    2016-01-01

    The merits of technology in general and of educational technology specifically are well documented. The use of educational technology has been shown to improve teaching and learning and the overall educational quality of schools. However, the successful integration of educational technology in schools hinges on school administrators' technology…

  11. Control technology standards as foundation for production monitoring systems; Steuerungstechnische Standards als Fundament fuer die Leittechnik

    Energy Technology Data Exchange (ETDEWEB)

    Hirzle, Anton [Daimler AG, Mercedes-Benz Cars, Werk Sindelfingen (DE). Automatisierungstechnologie und Simulation (PWT/VAS); Alosnso Garcia, Alexander [Daimler AG, Mercedes-Benz Cars, Werk Sindelfingen (Germany). PWT/VAS, Technologiesteuerungen und Robotik; Burkhardt, Andreas [Daimler AG, Mercedes-Benz Cars, Werk Sindelfingen (Germany). PWT/VAS, Steuerungstechnik

    2008-07-01

    Due to increasing demands on functionality, capacity and flexibility of manufacturing facilities, the complexity in automation technology grows continuously. Daimler AG faces this development with a consistent standardisation of automation- and control technology for assembly plants. Here the standardisation strategy is composed of three consecutive phases. Main point on aimed development and standardisation of a kit out of hard- and software components is in phase 1. Phase 2 contains the standardisation on system- and application level for whole plants like body in white, paint shop and assembly. Finally the standardisation of engineering processes is the third phase. (orig.)

  12. Co-culture of human embryos with autologous cumulus cell clusters and its beneficial impact of secreted growth factors on preimplantation development as compared to standard embryo culture in assisted reproductive technologies (ART

    Directory of Open Access Journals (Sweden)

    Alexandros Vithoulkas

    2017-12-01

    Conclusion(s: The investigated factors, among other substances, may be causally connected to the beneficial effect observed on embryo development. Our findings suggest that co-culture with autologous cumulus cell clusters improves the outcome of embryo culture in IVF programs.

  13. Advanced passive technology: A global standard for nuclear plant requirements

    International Nuclear Information System (INIS)

    Novak, V.

    1994-01-01

    Since 1984, Westinghouse has been developing AP8OO, a 800 MW, two-loop advanced passive plant, in response to an initiative established by the Electric Power Research Institute (EPRI) and the U.S. Department of Energy' (DOE). The preliminary design was cornpleved in 1989. AP6OO's Standard Safety Analysis and Probabilistic Risk analysis Reports were submitted to the U.S. Nuclear Regulatory Commission for design certification in 1992. Design simplification is the key strategy behind the AP6OO. The basic technical concept Of simplification has resulted in a simplified reactor coolant systems, simplified plant systems, a simplified plant arrangement, reduced number of components, simplified operation and maintenance

  14. Fuel cell technology; Brennstoffzellen-Technologie

    Energy Technology Data Exchange (ETDEWEB)

    Stimming, U; Friedrich, K A; Cappadonia, M; Vogel, R

    1999-12-31

    Hydrogen from fossil or renewable sources is an important fuel for low-emission power generation in fuel cells. Methanol and maybe also ethanol can also be produced by direct electrochemical processes in low-temperature fuel cells (PEMFC, PAFC). Fuel cell systems with high operating temperatures are highly flexible with regard to fuel but tend to have material problems. On the other hand, rapid developments in materials development and the possibility of production technology transfer from the electronics industry lead one to expect a breakthrough in the near future. But in spite of this, niche market applications will prevail. Since power stations have a longer life than motor vehicles and fuel cells in mobile applications, emission reductions from fuel cell applications in road vehicles are more probable on a medium-term basis than from applications in power stations. (orig.) [Deutsch] Wasserstoff, der sowohl aus fossilen wie auch aus regenerativen Quellen erschlossen werden kann, ist ein wesentlicher Brennstoff fuer die emissionsarme Elektrizitaetsproduktion in Brennstoffzellen. Methanol und eventuell Ethanol koennen auch direkt elektrochemisch in Niedertemperaturbrennstoffzellen (PEMFC, PAFC) umgesetzt werden. Brennstoffzellensysteme mit hohen Betriebstemperaturen erlauben eine hohe Flexibilitaet bezueglich der verwendeten Brennstoffe, sind aber nach wie vor durch starke Materialprobleme belastet. Die enormen Fortschritte in der Materialentwicklung einerseits sowie ein moeglicher Transfer von Fertigungstechnologien aus der Elektronikindustrie andererseits lassen eine zukuenftige grosstechnische Nutzung von Brennstoffzellen erwarten. Die technische Einfuehrung wird dennoch nur ueber Nischenmaerkte moeglich sein. Da die mittlere Lebensdauer eines Kraftwerks deutlich hoeher ist als die eines Strassenfahrzeugs, ausserdem Brennstoffzellen auch in staerkerem Masse in Fahrzeugen eingesetzt werden koennen, sind mittelfristig Emissionen eher durch

  15. Experience with local lymph node assay performance standards using standard radioactivity and nonradioactive cell count measurements.

    Science.gov (United States)

    Basketter, David; Kolle, Susanne N; Schrage, Arnhild; Honarvar, Naveed; Gamer, Armin O; van Ravenzwaay, Bennard; Landsiedel, Robert

    2012-08-01

    The local lymph node assay (LLNA) is the preferred test for identification of skin-sensitizing substances by measuring radioactive thymidine incorporation into the lymph node. To facilitate acceptance of nonradioactive variants, validation authorities have published harmonized minimum performance standards (PS) that the alternative endpoint assay must meet. In the present work, these standards were applied to a variant of the LLNA based on lymph node cell counts (LNCC) run in parallel as a control with the standard LLNA with radioactivity measurements, with threshold concentrations (EC3) being determined for the sensitizers. Of the 22 PS chemicals tested in this study, 21 yielded the same results from standard radioactivity and cell count measurements; only 2-mercaptobenzothiazole was positive by LLNA but negative by LNCC. Of the 16 PS positives, 15 were positive by LLNA and 14 by LNCC; methylmethacrylate was not identified as sensitizer by either of the measurements. Two of the six PS negatives tested negative in our study by both LLNA and LNCC. Of the four PS negatives which were positive in our study, chlorobenzene and methyl salicylate were tested at higher concentrations than the published PS, whereas the corresponding concentrations resulted in consistent negative results. Methylmethacrylate and nickel chloride tested positive within the concentration range used for the published PS. The results indicate cell counts and radioactive measurements are in good accordance within the same LLNA using the 22 PS test substances. Comparisons with the published PS results may, however, require balanced analysis rather than a simple checklist approach. Copyright © 2011 John Wiley & Sons, Ltd.

  16. States and tendencies of German standards in the field of nuclear filter technology

    International Nuclear Information System (INIS)

    Fichtner, N.; Sinhuber, D.

    1977-01-01

    The current situation in the Federal Republic of Germany with regard to standards and guidelines in the field of filter technology, as they apply to nuclear technology, is first presented. A detailed discussion follows of the results arrived at by the Nuclear Technology Standards Committee in its deliberations on the Standards' project DIN 25 414 'Ventilation equipment in nuclear power stations'. Particular attention is paid to the technical safety requirements for particulate filters, filter casings and filter housings, and methods of testing. The results so far obtained as regards filters in ventilation plant for pressurized water reactors are also dealt with

  17. ‘Standards’ on the bench: Do Standards for technological literacy render an adequate image of technology?

    Directory of Open Access Journals (Sweden)

    Mahdi G. Nia

    2016-03-01

    Full Text Available The technological literacy of students has recently become one of the primary goals of education in countries such as the USA, England, New Zealand, Australia, and so forth. However the question here is whether these educations – their long-term policy documents as well as the standards they provide in particular – address sufficient learning about the nature of technology. This seems to be an important concern that through taking advantage of the philosophy of technology (the arena which affords a bountiful ground of various reflections on the nature of technology is intended to be discussed throughout this study. In the first place, the paper presents a relevant framework based upon Mitcham’s (1994 four-aspect account of technology, i.e., technology as objects, knowledge, activities, and volition. Then it categorizes the main relevant concepts and concerns put forward by many other philosophers of technology into this framework; this will yield a concrete model (tool to analyze any intended standard such as the above mentioned ones. Afterwards, to show how this model works, the well-known case of the USA – Standards for Technological Literacy (ITEA, 2007 – will be used as an example for inspection; the results will disclose the points where the current American case needs to be modified.

  18. Exemplary Design Envelope Specification for Standard Modular Hydropower Technology

    Energy Technology Data Exchange (ETDEWEB)

    Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tsakiris, Achilleas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Papanicolaou, Thanos [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Pries, Jason L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burress, Timothy A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Kyutae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pracheil, Brenda M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McManamay, Ryan A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ekici, Kivanc [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Kutz, Benjamin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Curd, Shelaine L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bishop, Norm [Knight Piesold, Denver, CO (United States); Welch, Tim [U.S. Department of Energy (DOE), Washington, DC (United States). Office of Energy Efficiency and Renewable Energy (EERE); Rabon, Daniel [U.S. Department of Energy (DOE), Washington, DC (United States). Office of Energy Efficiency and Renewable Energy (EERE); Fernandez, Alisha [McKeown and Associates, Moberly, MO (United States)

    2017-02-01

    Hydropower is an established, affordable renewable energy generation technology supplying nearly 18% of the electricity consumed globally. A hydropower facility interacts continuously with the surrounding water resource environment, causing alterations of varying magnitude in the natural flow of water, energy, fish, sediment, and recreation upstream and downstream. A universal challenge in facility design is balancing the extraction of useful energy and power system services from a stream with the need to maintain ecosystem processes and natural environmental function. On one hand, hydroelectric power is a carbon-free, renewable, and flexible asset to the power system. On the other, the disruption of longitudinal connectivity and the artificial barrier to aquatic movement created by hydraulic structures can produce negative impacts that stress fresh water environments. The growing need for carbon-free, reliable, efficient distributed energy sources suggests there is significant potential for hydropower projects that can deploy with low installed costs, enhanced ecosystem service offerings, and minimal disruptions of the stream environment.

  19. Advanced passive technology: A global standard for nuclear plant requirements

    Energy Technology Data Exchange (ETDEWEB)

    Novak, V

    1994-12-31

    Since 1984, Westinghouse has been developing AP8OO, a 800 MW, two-loop advanced passive plant, in response to an initiative established by the Electric Power Research Institute (EPRI) and the U.S. Department of Energy` (DOE). The preliminary design was cornpleved in 1989. AP6OO`s Standard Safety Analysis and Probabilistic Risk analysis Reports were submitted to the U.S. Nuclear Regulatory Commission for design certification in 1992. Design simplification is the key strategy behind the AP6OO. The basic technical concept Of simplification has resulted in a simplified reactor coolant systems, simplified plant systems, a simplified plant arrangement, reduced number of components, simplified operation and maintenance.

  20. Technological characteristics of digital video broadcasting: Handheld standard DVB-H

    Directory of Open Access Journals (Sweden)

    Andreja B. Samčović

    2011-07-01

    Full Text Available This paper gives an overview of the Digital Video Broadcasting - Handheld standard DVB-H, as a part of the DVB Project. This standard is based on the previous standard DVB-T, which was developed for the terrestrial digital television. The ways of DVB-H signal transmission are also described. Development of advanced technology enabled the digital video broadcasting over wireless portable terminals. This paper discusses the key technological features of the DVB-H standard, such as: time slicing, forward error correction, 4K mode and in-depth interleavers.

  1. Continued SOFC cell and stack technology and improved production methods

    Energy Technology Data Exchange (ETDEWEB)

    Wandel, M.; Brodersen, K.; Phair, J. (and others)

    2009-05-15

    Within this project significant results are obtained on a number of very diverse areas ranging from development of cell production, metallic creep in interconnect to assembling and test of stacks with foot print larger than 500 cm2. Out of 38 milestones 28 have been fulfilled and 10 have been partly fulfilled. This project has focused on three main areas: 1) The continued cell development and optimization of manufacturing processes aiming at production of large foot-print cells, improving cell performance and development environmentally more benign production methods. 2) Stack technology - especially stacks with large foot print and improving the stack design with respect to flow geometry and gas leakages. 3) Development of stack components with emphasis on sealing (for 2G as well as 3G), interconnect (coat, architecture and creep) and test development. Production of cells with a foot print larger than 500 cm2 is very difficult due to the brittleness of the cells and great effort has been put into this topic. Eight cells were successfully produced making it possible to assemble and test a real stack thereby giving valuable results on the prospects of stacks with large foot print. However, the yield rate is very low and a significant development to increase this yield lies ahead. Several lessons were learned on the stack level regarding 'large foot print' stacks. Modelling studies showed that the width of the cell primarily is limited by production and handling of the cell whereas the length (in the flow direction) is limited by e.g. pressure drop and necessary manifolding. The optimal cell size in the flow direction was calculated to be between approx20 cm and < 30 cm. From an economical point of view the production yield is crucial and stacks with large foot print cell area are only feasible if the cell production yield is significantly enhanced. Co-casting has been pursued as a production technique due to the possibilities in large scale production

  2. CANDIED PUMPKIN; TECHNOLOGY FOR ITS PREPARATION AND STANDARD FOR ORGANIZATION

    Directory of Open Access Journals (Sweden)

    L. V. Pavlov

    2017-01-01

    Full Text Available Standard for organization for candied pumpkin has been developed. Industrial raw material. The following ‘Technical Specifications’ included: definitions, terms, abbreviations, technical requirements, orders of reception, trial methods, transportation and storage, labor protection, fire security and reference list. The product is pumpkin pulp cut to pieces of different shapes and sizes boiled in sugar syrup, dried and coated with granulated sugar. Fruits of pumpkin that need for production are obliged to be in the phase of biologically freshness and maturity, healthy, without soiling. The cultivars for table use with smooth peel, thick and dense, not fibrous pulp with thickness over 3 cm. and deepyellow or bright-orange color are taken. The finished products are packed according to GOST. The candied pumpkin is well preserved up to six month for retail sale and up to 12 month for further industrial processing. The candied pumpkin is stored in dried and well ventilated room with relative air humidity below 75% and temperature from 0° to 20°C.

  3. NREL Solar Cell Wins Federal Technology Transfer Prize | News | NREL

    Science.gov (United States)

    Solar Cell Wins Federal Technology Transfer Prize News Release: NREL Solar Cell Wins Federal Technology Transfer Prize May 7, 2009 A new class of ultra-light, high-efficiency solar cells developed by the U.S. Department of Energy's National Renewable Energy Laboratory has been awarded a national prize

  4. Activities of the data centers on atomic spectroscopy at the National Institute of Standards and Technology

    International Nuclear Information System (INIS)

    Wiese, W.L.

    1990-01-01

    The activities concerning Atomic Energy Levels and Wavelengths, Atomic Transition Probabilities and Spectral Line Shapes and Shifts at the National Institute of Standards and Technology (Gaithersburg, USA) are listed together with the corresponding lists of publications

  5. Guidelines on Active Content and Mobile Code: Recommendations of the National Institute of Standards and Technology

    National Research Council Canada - National Science Library

    Jansen, Wayne

    2001-01-01

    .... One such category of technologies is active content. Broadly speaking, active content refers to electronic documents that, unlike past character documents based on the American Standard Code for Information Interchange (ASCII...

  6. Evolving diesel common rail technology for future low emission standards

    Energy Technology Data Exchange (ETDEWEB)

    Schoeppe, D.; Bercher, P.; Guerrassi, N.; Spadafora, P. [Delphi Diesel Systems, Paris (France)

    2005-07-01

    The Diesel fuel injection equipment will remain a key element for Diesel engine technology evolution. Achieving emission targets at competitive prices has been and will continue to be a major technical challenge to the engine manufacturer. Delphi is continously developing its Common Rail System and its components for fulfill future stricter emission legislation while simultaneously improving performance on noise, fuel consumption and power output. The outstanding and unique injector concept combined with innovative control strategies has largely contributed to the improvement of exhaust emission and performance, consumption and NVH over the lifetime of Diesel vehicles. Recently, Euro 4 common rail applications have been introduced on several applications by adding further capability such as multiple injection, small-injected quantity control and improved atomization. This papers will describe the latest Common Rail System developments that Delphi will introduce into the market to comply with future legislative emission targets. Further, a novel common rail injector will be presented, that uses a revolutionary, direct acting operating principle, where the nozzle is directly operated by a piezo actuator, without the use of a servo-hydraulic flow circuit. The superior performance of this injector concept will be shown, especially with regard to it's near square rate injection shape, minimum quantity capability as well as multiple injection performance. The direct acting operating principle allows rapid opening and closing of the injector, without compromising pilot quantity capability. The emission benefit obtained by such opening and closing behavior will be shown. Finally, based on the findings discussed, the papers will conclude on key features of future common rail systems. (orig.)

  7. Application of single-cell technology in cancer research.

    Science.gov (United States)

    Liang, Shao-Bo; Fu, Li-Wu

    2017-07-01

    In this review, we have outlined the application of single-cell technology in cancer research. Single-cell technology has made encouraging progress in recent years and now provides the means to detect rare cancer cells such as circulating tumor cells and cancer stem cells. We reveal how this technology has advanced the analysis of intratumor heterogeneity and tumor epigenetics, and guided individualized treatment strategies. The future prospects now are to bring single-cell technology into the clinical arena. We believe that the clinical application of single-cell technology will be beneficial in cancer diagnostics and treatment, and ultimately improve survival in cancer patients. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Accomplishing PETE Learning Standards and Program Accreditation through Teacher Candidates' Technology-Based Service Learning Projects

    Science.gov (United States)

    Gibbone, Anne; Mercier, Kevin

    2014-01-01

    Teacher candidates' use of technology is a component of physical education teacher education (PETE) program learning goals and accreditation standards. The methods presented in this article can help teacher candidates to learn about and apply technology as an instructional tool prior to and during field or clinical experiences. The goal in…

  9. 75 FR 62399 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

    Science.gov (United States)

    2010-10-08

    ... Technology; HIT Standards Committee Schedule for the Assessment of HIT Policy Committee Recommendations.... SUMMARY: Section 3003(b)(3) of the American Recovery and Reinvestment Act of 2009 mandates that the HIT Standards Committee develop a schedule for the assessment of policy recommendations developed by the HIT...

  10. Study on the operation mode for indigenization and standardization of AP1000 technology

    International Nuclear Information System (INIS)

    Gao Zhihu; Cheng Huiping

    2014-01-01

    This paper describes the importance and necessity of developing standardized AP1000 technology, and analyzes the problems faced and measures to be taken. The operation mode, known as the Committee of AP1000 Standardized Design and Innovation Management, was first put forward in China. And the paper also discusses how to arouse the enthusiasm of the owners, designers, manufactures, as well as construction, installation, regulation and other parties, how to exploit the advantage of whole industry to promote the localization and standardization of AP1000 technology. (authors)

  11. Technical standardization of oil well abandonment: a review of current standards and technologies

    Energy Technology Data Exchange (ETDEWEB)

    Suzart, J. Walter P.; Pessoa, Laudemar; Paiva, Maria [Halliburton Energy Services (HES), Duncan, OK (United States)

    2008-07-01

    The objective of this study is to provide a new methodology for well abandonment. This practice is becoming more and more important because of the increasing number of production fields being abandoned. We strongly recommend a study of cement slurries properties for specific use in temporary and permanent abandonment plugs based on the estimation of the cement slurry hardened when placed in the well. By using specific additives, it is possible to achieve very stable slurries. For example, when permeability is reduced, formation fluid migration can be blocked and chemical reactions between the fluid and the slurry may be inhibited. With this objective, we present a laboratory investigation model and an example of slurry testing recommendation. During the abandonment operation, all records of the well characteristics should be maintained to include the reason for the abandonment, and location of fresh water, brine, and hydrocarbon zones that may exist. This documentation will also allow the analysis of solutions for the problems that originally caused the abandonment of the well. This data could be important for future use by environmental protection commissions to reopen or to drill an adjacent well. Given the high price of oil, it may now be economically feasible to reopen the well, if the reason for abandonment was low productivity. This way, a critical analysis of the current conditions of well and field abandonment in the country is presented. Based on this information, a review of the current standards is suggested. (author)

  12. A Multi-Year Plan for Research, Development, and Prototype Testing of Standard Modular Hydropower Technology

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Welch, Tim [U.S. Department of Energy (DOE), Washington, DC (United States).Office of Energy Efficiency and Renewable Energy (EERE); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Kyutae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burress, Timothy A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pracheil, Brenda M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pries, Jason L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); O' Connor, Patrick W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Curd, Shelaine L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ekici, Kivanc [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Papanicolaou, Thanos [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Tsakiris, Achilleas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Kutz, Benjamin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Bishop, Norm [Knight Piesold, Denver, CO (United States); McKeown, Alisha [McKeown and Associates, Moberly, MO (United States); Rabon, Daniel [U.S. Department of Energy (DOE), Washington, DC (United States).Office of Energy Efficiency and Renewable Energy (EERE); Zimmerman, Gregory P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Uria Martinez, Rocio [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McManamay, Ryan A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    The Multi-Year Plan for Research, Development, and Prototype Testing of Standard Modular Hydropower Technology (MYRP) presents a strategy for specifying, designing, testing, and demonstrating the efficacy of standard modular hydropower (SMH) as an environmentally compatible and cost-optimized renewable electricity generation technology. The MYRP provides the context, background, and vision for testing the SMH hypothesis: if standardization, modularity, and preservation of stream functionality become essential and fully realized features of hydropower technology, project design, and regulatory processes, they will enable previously unrealized levels of new project development with increased acceptance, reduced costs, increased predictability of outcomes, and increased value to stakeholders. To achieve success in this effort, the MYRP outlines a framework of stakeholder-validated criteria, models, design tools, testing facilities, and assessment protocols that will facilitate the development of next-generation hydropower technologies.

  13. A new principle for low-cost hydrogen sensors for fuel cell technology safety

    Energy Technology Data Exchange (ETDEWEB)

    Liess, Martin [Rhein Main University of Applied Sciences, Rüsselsheim, Wiesbaden (Germany)

    2014-03-24

    Hydrogen sensors are of paramount importance for the safety of hydrogen fuel cell technology as result of the high pressure necessary in fuel tanks and its low explosion limit. I present a novel sensor principle based on thermal conduction that is very sensitive to hydrogen, highly specific and can operate on low temperatures. As opposed to other thermal sensors it can be operated with low cost and low power driving electronics. On top of this, as sensor element a modified standard of-the shelf MEMS thermopile IR-sensor can be used. The sensor principle presented is thus suited for the future mass markets of hydrogen fuel cell technology.S.

  14. Definition and compositions of standard wastestreams for evaluation of Buried Waste Integrated Demonstration treatment technologies

    International Nuclear Information System (INIS)

    Bates, S.O.

    1993-06-01

    The Buried Waste Integrated Demonstration (BWID) Project was organized at the Idaho National Engineering Laboratory to support research, development, demonstration, testing, and evaluation of emerging technologies that offer promising solutions to remediation of buried waste. BWID will identify emerging technologies, screen them for applicability to the identified needs, select technologies for demonstration, and then evaluate the technologies based on prescribed performance objectives. The technical objective of the project is to establish solutions to Environmental Restoration and Waste Management's technological deficiencies and improve baseline remediation systems. This report establishes a set of standard wastestream compositions that will be used by BWID to evaluate the emerging technologies. Five wastestreams are proposed that use four types of waste and a nominal case that is a homogenized combination of the four wastes. The five wastestreams will provide data on the compositional extremes and indicate the technologies' effectiveness over the complete range of expected wastestream compositions

  15. Standardization of quantum technologies and QKD activities within ETSI (Conference Presentation)

    Science.gov (United States)

    Lenhart, Gaby

    2016-04-01

    In order to establish new ICT technologies successfully on the market it is essential to build trust within any potential users. This is especially true for technologies which are based upon paradigms that are not yet familiar to these users, such as quantum technologies. Technical standards are an excellent means to offer a certain degree of legal reliability and technical interoperability that is required by industry for commercial take up. While such standards on the one hand must be clear enough to provide strict rules for implementers, on the other hand they also must remain flexible enough to not restrict progress in further research and development on the standardized technology. Hence such standards have to be produced by a wide variety of stakeholders taking into account all their different needs. The paper will provide some insight into the general mechanisms of standardization and their relation to quantum technologies. Alongside with the relevance of standardization as an enabler for certification of quantum based technologies it will explain its potential for securing intellectual property. In its first part paper will concentrate on the advantages of standardization and discuss fears some of the stakeholders share, in detail. The second part will focus on the technical work going on in ETSI in relation to quantum technologies. In 2008 ETSI created a standards work group on Quantum Key Distribution, the ETSI ISG QKD and more recently a group on Quantum-Safe Cryptography, the ETSI ISG QSC. A significant part of the technical work of these groups has already been published and will be introduced in the following. However a big share of work is still ongoing and lot more is planned for the future, as are continuous revisions and updates of the published specifications. This standardization work covers several levels: It starts of by problem statements in the form of use cases, from which technical requirements can be derived. These requirements then form

  16. The need for a common standard for voltage levels of HVDC VSC technology

    International Nuclear Information System (INIS)

    Müller, H.K.; Torbaghan, S. Shariat; Gibescu, M.; Roggenkamp, M.M.; Meijden, M.A.M.M. van der

    2013-01-01

    The expansion of offshore wind energy as well as the increase in electricity trade between the North Sea countries leads to a growing need for additional transmission capacity. Due to the predominantly remote locations of offshore wind farms, the majority of future connections will be high-voltage direct current (HVDC) connections. In order to make the construction of offshore infrastructure more efficient, the North Sea states are currently discussing the development of a common offshore grid. Although this development still stands at the very beginning, we argue in this paper that some crucial elements should be standardized from the outset; the most important one being a common voltage level. Without such standardization, the development of a European offshore grid may be suboptimal, not cost-efficient and might even be prevented from coming into existence. We examine the technical and legal issues associated with introducing a common voltage level for the use of HVDC VSC technology, and discuss the optimal standard as well as the way in which this common standard can best be achieved. - Highlights: • We highlight the need for a common standard for HVDC VSC technology. • We outline that a standardized voltage level at ± 500 kV should be the initial focus. • We discuss the developments regarding standardization of HVDC VSC technology. • We conclude that current developments are not sufficient

  17. Stem cell technology for drug discovery and development.

    Science.gov (United States)

    Hook, Lilian A

    2012-04-01

    Stem cells have enormous potential to revolutionise the drug discovery process at all stages, from target identification through to toxicology studies. Their ability to generate physiologically relevant cells in limitless supply makes them an attractive alternative to currently used recombinant cell lines or primary cells. However, realisation of the full potential of stem cells is currently hampered by the difficulty in routinely directing stem cell differentiation to reproducibly and cost effectively generate pure populations of specific cell types. In this article we discuss how stem cells have already been used in the drug discovery process and how novel technologies, particularly in relation to stem cell differentiation, can be applied to attain widespread adoption of stem cell technology by the pharmaceutical industry. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. Studies of cell biomechanics with surface micro-/nano-technology

    International Nuclear Information System (INIS)

    Wang Dong; Zhang Wei; Jiang Xingyu

    2011-01-01

    We report the recent progress in our studies of cell biology using micro-/nano-technology. Cells have a size of several to tens of microns, which makes them easily manipulated by micro-/nano-technology. The shape of the cell influences the alignment of the actin cytoskeleton, which bears the main forces of the cell, maintains the shape,and mediates a series of biochemical reactions. We invented a stretching device and studied the real-time actin filament dynamics under stretch. We found that one stretch cycle shortened the actin filaments and promoted their reassemble process. Cell migration is a complex mechanical process. We found that cell geometry determines the cell polarity and migration direction. We fabricated three-dimensional surfaces to mimic the topography in vivo, and further built a cell culture model by integrating the three-dimensional surface, microfluidics, cell patterning,and coculturing of multiple cell types. We also investigated the neuronal guidance by surface patterning. (authors)

  19. Standard Test Method for Electrical Performance of Photovoltaic Cells Using Reference Cells Under Simulated Sunlight

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2009-01-01

    1.1 This test method covers the determination of the electrical performance of a photovoltaic cell under simulated sunlight by means of a calibrated reference cell procedure. 1.2 Electrical performance measurements are reported with respect to a select set of standard reporting conditions (SRC) (see Table 1) or to user-specified conditions. 1.2.1 The SRC or user-specified conditions include the cell temperature, the total irradiance, and the reference spectral irradiance distribution. 1.3 This test method is applicable only to photovoltaic cells with a linear response over the range of interest. 1.4 The cell parameters determined by this test method apply only at the time of test, and imply no past or future performance level. 1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this s...

  20. Avelumab: a new standard for treating metastatic Merkel cell carcinoma.

    Science.gov (United States)

    Baker, Mairead; Cordes, Lisa; Brownell, Isaac

    2018-04-01

    Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer. Although MCC is chemosensitive, responses to traditional chemotherapeutic agents are not durable. Avelumab, a novel anti-PD-L1 immune checkpoint inhibitor, recently became the first FDA-approved agent for the treatment of metastatic MCC and represents a new option to improve patient survival. Areas covered: This article presents an overview of MCC and summarizes the development of avelumab in the treatment of metastatic MCC. Preclinical studies, phase 1 and phase 2 clinical trials, and the safety profile of avelumab are reviewed. Future perspectives and ongoing studies are also discussed. Expert commentary: Avelumab demonstrated rapid and durable responses and a manageable safety profile in the treatment of metastatic MCC. Patient outcomes are favorable when compared to historical responses to standard chemotherapy. Ongoing clinical trials will continue to characterize avelumab and its optimal use in MCC therapy.

  1. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2015

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-01-08

    This FY 2015 report updates the results of an effort to identify and document the commercial and emerging (projected to be commercialized within the next 3 to 5 years) hydrogen and fuel cell technologies and products that resulted from U.S. Department of Energy support through the Fuel Cell Technologies Office in the Office of Energy Efficiency and Renewable Energy.

  2. From the primordial soup to self-driving cars: standards and their role in natural and technological innovation.

    Science.gov (United States)

    Wagner, Andreas; Ortman, Scott; Maxfield, Robert

    2016-02-01

    Standards are specifications to which the elements of a technology must conform. Here, we apply this notion to the biochemical 'technologies' of nature, where objects like DNA and proteins, as well as processes like the regulation of gene activity are highly standardized. We introduce the concept of standards with multiple examples, ranging from the ancient genetic material RNA, to Palaeolithic stone axes, and digital electronics, and we discuss common ways in which standards emerge in nature and technology. We then focus on the question of how standards can facilitate technological and biological innovation. Innovation-enhancing standards include those of proteins and digital electronics. They share common features, such as that few standardized building blocks can be combined through standard interfaces to create myriad useful objects or processes. We argue that such features will also characterize the most innovation-enhancing standards of future technologies. © 2016 The Author(s).

  3. Understanding the build-up of a technological innovation system around hydrogen and fuel cell technologies

    NARCIS (Netherlands)

    Suurs, R.A.A.; Hekkert, M.P.; Smits, R.E.H.M.

    2009-01-01

    This study provides insight into the development of hydrogen and fuel cell technologies in the Netherlands (1980-2007). This is done by applying a Technological Innovation System (TIS) approach. This approach takes the perspective that a technology is shaped by a surrounding network of actors,

  4. An efficient auto TPT stitch guidance generation for optimized standard cell design

    Science.gov (United States)

    Samboju, Nagaraj C.; Choi, Soo-Han; Arikati, Srini; Cilingir, Erdem

    2015-03-01

    As the technology continues to shrink below 14nm, triple patterning lithography (TPT) is a worthwhile lithography methodology for printing dense layers such as Metal1. However, this increases the complexity of standard cell design, as it is very difficult to develop a TPT compliant layout without compromising on the area. Hence, this emphasizes the importance to have an accurate stitch generation methodology to meet the standard cell area requirement as defined by the technology shrink factor. In this paper, we present an efficient auto TPT stitch guidance generation technique for optimized standard cell design. The basic idea here is to first identify the conflicting polygons based on the Fix Guidance [1] solution developed by Synopsys. Fix Guidance is a reduced sub-graph containing minimum set of edges along with the connecting polygons; by eliminating these edges in a design 3-color conflicts can be resolved. Once the conflicting polygons are identified using this method, they are categorized into four types [2] - (Type 1 to 4). The categorization is based on number of interactions a polygon has with the coloring links and the triangle loops of fix guidance. For each type a certain criteria for keep-out region is defined, based on which the final stitch guidance locations are generated. This technique provides various possible stitch locations to the user and helps the user to select the best stitch location considering both design flexibility (max. pin access/small area) and process-preferences. Based on this technique, a standard cell library for place and route (P and R) can be developed with colorless data and a stitch marker defined by designer using our proposed method. After P and R, the full chip (block) would contain the colorless data and standard cell stitch markers only. These stitch markers are considered as "must be stitch" candidates. Hence during full chip decomposition it is not required to generate and select the stitch markers again for the

  5. Standard guide for hot cell specialized support equipment and tools

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 Intent: 1.1.1 This guide presents practices and guidelines for the design and implementation of equipment and tools to assist assembly, disassembly, alignment, fastening, maintenance, or general handling of equipment in a hot cell. Operating in a remote hot cell environment significantly increases the difficulty and time required to perform a task compared to completing a similar task directly by hand. Successful specialized support equipment and tools minimize the required effort, reduce risks, and increase operating efficiencies. 1.2 Applicability: 1.2.1 This guide may apply to the design of specialized support equipment and tools anywhere it is remotely operated, maintained, and viewed through shielding windows or by other remote viewing systems. 1.2.2 Consideration should be given to the need for specialized support equipment and tools early in the design process. 1.2.3 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conv...

  6. NextGen Technologies on the FAA's Standard Terminal Automation Replacement System

    Science.gov (United States)

    Witzberger, Kevin; Swenson, Harry; Martin, Lynne; Lin, Melody; Cheng, Jinn-Hwei

    2014-01-01

    This paper describes the integration, evaluation, and results from a high-fidelity human-in-the-loop (HITL) simulation of key NASA Air Traffic Management Technology Demonstration - 1 (ATD- 1) technologies implemented in an enhanced version of the FAA's Standard Terminal Automation Replacement System (STARS) platform. These ATD-1 technologies include: (1) a NASA enhanced version of the FAA's Time-Based Flow Management, (2) a NASA ground-based automation technology known as controller-managed spacing (CMS), and (3) a NASA advanced avionics airborne technology known as flight-deck interval management (FIM). These ATD-1 technologies have been extensively tested in large-scale HITL simulations using general-purpose workstations to study air transportation technologies. These general purpose workstations perform multiple functions and are collectively referred to as the Multi-Aircraft Control System (MACS). Researchers at NASA Ames Research Center and Raytheon collaborated to augment the STARS platform by including CMS and FIM advisory tools to validate the feasibility of integrating these automation enhancements into the current FAA automation infrastructure. NASA Ames acquired three STARS terminal controller workstations, and then integrated the ATD-1 technologies. HITL simulations were conducted to evaluate the ATD-1 technologies when using the STARS platform. These results were compared with the results obtained when the ATD-1 technologies were tested in the MACS environment. Results collected from the numerical data show acceptably minor differences, and, together with the subjective controller questionnaires showing a trend towards preferring STARS, validate the ATD-1/STARS integration.

  7. Review on thin-film transistor technology, its applications, and possible new applications to biological cells

    Science.gov (United States)

    Tixier-Mita, Agnès; Ihida, Satoshi; Ségard, Bertrand-David; Cathcart, Grant A.; Takahashi, Takuya; Fujita, Hiroyuki; Toshiyoshi, Hiroshi

    2016-04-01

    This paper presents a review on state-of-the-art of thin-film transistor (TFT) technology and its wide range of applications, not only in liquid crystal displays (TFT-LCDs), but also in sensing devices. The history of the evolution of the technology is first given. Then the standard applications of TFT-LCDs, and X-ray detectors, followed by state-of-the-art applications in the field of chemical and biochemical sensing are presented. TFT technology allows the fabrication of dense arrays of independent and transparent microelectrodes on large glass substrates. The potential of these devices as electrical substrates for biological cell applications is then described. The possibility of using TFT array substrates as new tools for electrical experiments on biological cells has been investigated for the first time by our group. Dielectrophoresis experiments and impedance measurements on yeast cells are presented here. Their promising results open the door towards new applications of TFT technology.

  8. Micro/nano-fabrication technologies for cell biology.

    Science.gov (United States)

    Qian, Tongcheng; Wang, Yingxiao

    2010-10-01

    Micro/nano-fabrication techniques, such as soft lithography and electrospinning, have been well-developed and widely applied in many research fields in the past decade. Due to the low costs and simple procedures, these techniques have become important and popular for biological studies. In this review, we focus on the studies integrating micro/nano-fabrication work to elucidate the molecular mechanism of signaling transduction in cell biology. We first describe different micro/nano-fabrication technologies, including techniques generating three-dimensional scaffolds for tissue engineering. We then introduce the application of these technologies in manipulating the physical or chemical micro/nano-environment to regulate the cellular behavior and response, such as cell life and death, differentiation, proliferation, and cell migration. Recent advancement in integrating the micro/nano-technologies and live cell imaging are also discussed. Finally, potential schemes in cell biology involving micro/nano-fabrication technologies are proposed to provide perspectives on the future research activities.

  9. Proceedings -- US Russian workshop on fuel cell technologies

    Energy Technology Data Exchange (ETDEWEB)

    Baker, B.; Sylwester, A. [comps.

    1996-04-01

    On September 26--28, 1995, Sandia National Laboratories sponsored the first Joint US/Russian Workshop on Fuel Cell Technology at the Marriott Hotel in Albuquerque, New Mexico. This workshop brought together the US and Russian fuel cell communities as represented by users, producers, R and D establishments and government agencies. Customer needs and potential markets in both countries were discussed to establish a customer focus for the workshop. Parallel technical sessions defined research needs and opportunities for collaboration to advance fuel cell technology. A desired outcome of the workshop was the formation of a Russian/American Fuel Cell Consortium to advance fuel cell technology for application in emerging markets in both countries. This consortium is envisioned to involve industry and national labs in both countries. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  10. Micro and Nano-Scale Technologies for Cell Mechanics

    Directory of Open Access Journals (Sweden)

    Mustafa Unal

    2014-10-01

    Full Text Available Cell mechanics is a multidisciplinary field that bridges cell biology, fundamental mechanics, and micro and nanotechnology, which synergize to help us better understand the intricacies and the complex nature of cells in their native environment. With recent advances in nanotechnology, microfabrication methods and micro-electro-mechanical-systems (MEMS, we are now well situated to tap into the complex micro world of cells. The field that brings biology and MEMS together is known as Biological MEMS (BioMEMS. BioMEMS take advantage of systematic design and fabrication methods to create platforms that allow us to study cells like never before. These new technologies have been rapidly advancing the study of cell mechanics. This review article provides a succinct overview of cell mechanics and comprehensively surveys micro and nano-scale technologies that have been specifically developed for and are relevant to the mechanics of cells. Here we focus on micro and nano-scale technologies, and their applications in biology and medicine, including imaging, single cell analysis, cancer cell mechanics, organ-on-a-chip systems, pathogen detection, implantable devices, neuroscience and neurophysiology. We also provide a perspective on the future directions and challenges of technologies that relate to the mechanics of cells.

  11. Towards the Development of a Model for Hardware Standards in Information Technology Procurement: Factors for Consideration

    Science.gov (United States)

    Ryan, David L.

    2010-01-01

    While research in academic and professional information technology (IT) journals address the need for strategic alignment and defined IT processes, there is little research about what factors should be considered when implementing specific IT hardware standards in an organization. The purpose of this study was to develop a set of factors for…

  12. Physical and electrical bandwidths of integrated photodiodes in standard CMOS technology

    NARCIS (Netherlands)

    Radovanovic, S.; Annema, Anne J.; Nauta, Bram

    2003-01-01

    The influence of different geometries (layouts) and structures of high-speed photodiodes in fully standard 0.18 μm CMOS technology on their intrinsic (physical) and electrical bandwidths is analyzed. Three photodiode structures are studied: nwell/p-substrate, p+/nwell/p-substrate and p+/nwell. The

  13. Nanotechnology Laboratory Continues Partnership with FDA and National Institute of Standards and Technology | Poster

    Science.gov (United States)

    The NCI-funded Nanotechnology Characterization Laboratory (NCL)—a leader in evaluating promising nanomedicines to fight cancer—recently renewed its collaboration with the U.S. Food and Drug Administration (FDA) and the National Institute of Standards and Technology (NIST) to continue its groundbreaking work on characterizing nanomedicines and moving them toward the clinic. In

  14. Standards, Firewalls, and General Classroom Mayhem: Implementing Student-Centered Technology Projects in the Elementary Classroom

    Science.gov (United States)

    Hofer, Mark; Swan, Kathleen Owings

    2006-01-01

    Educators are simultaneously bombarded with both calls to integrate technology in meaningful ways into their teaching and to promote more student-centered activities which combine both content learning and higher-order thinking. This is no small task given the range of student abilities and interests, the increasing emphasis on state standards and…

  15. 78 FR 66107 - National Emissions Standards for Hazardous Air Pollutants Residual Risk and Technology Review for...

    Science.gov (United States)

    2013-11-04

    ... estimate VCS voluntary consensus standards WWW world wide web Organization of this Document. The... oxidizer RTR residual risk and technology review SAB Science Advisory Board SBA Small Business... acceptable in the world in which we live'' (Risk Report at 178, quoting NRDC v. EPA, 824 F.2d 1146, 1165 (D.C...

  16. National Educators' Workshop: Update 1988. Standard Experiments in Engineering Materials Science and Technology

    Science.gov (United States)

    Gardner, James E. (Compiler); Jacobs, James A. (Compiler)

    1990-01-01

    Presented here is a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 88, held May 10 to 12, 1988 at the National Institute of Standards and Technology (NIST), Gaithersberg, Maryland. The experiments related to the nature and properties of engineering materials and provided information to assist in teaching about materials in the education community.

  17. Taiwanese Science and Life Technology Curriculum Standards and Earth Systems Education

    Science.gov (United States)

    Chang, Chun-Yen

    2005-01-01

    In the past several years, curriculum reform has received increasing attention from educators in many countries around the world. Recently, Taiwan has developed new Science and Life Technology Curriculum Standards (SaLTS) for grades 1-9. SaLTS features a systematic way for developing students' understanding and appreciation of…

  18. Single-cell technologies to study the immune system.

    Science.gov (United States)

    Proserpio, Valentina; Mahata, Bidesh

    2016-02-01

    The immune system is composed of a variety of cells that act in a coordinated fashion to protect the organism against a multitude of different pathogens. The great variability of existing pathogens corresponds to a similar high heterogeneity of the immune cells. The study of individual immune cells, the fundamental unit of immunity, has recently transformed from a qualitative microscopic imaging to a nearly complete quantitative transcriptomic analysis. This shift has been driven by the rapid development of multiple single-cell technologies. These new advances are expected to boost the detection of less frequent cell types and transient or intermediate cell states. They will highlight the individuality of each single cell and greatly expand the resolution of current available classifications and differentiation trajectories. In this review we discuss the recent advancement and application of single-cell technologies, their limitations and future applications to study the immune system. © 2015 The Authors. Immunology Published by John Wiley & Sons Ltd.

  19. New Advanced Technologies in Stem Cell Therapy

    Science.gov (United States)

    2014-11-01

    James, J. N. Zara , M. Corselli et al., “An abundant perivascular source of stem cells for bone tissue engineering,” Stem Cells Translational Medicine...vol. 1, no. 9, pp. 673–684, 2012. [89] A.W. James, J. N. Zara , X. Zhang et al., “Perivascular stem cells: a prospectively purified mesenchymal stem...1, pp. 54–63, 2009. [176] A. Askarinam, A. W. James, J. N. Zara et al., “Human perivas- cular stem cells show enhanced osteogenesis and

  20. ADEpedia: a scalable and standardized knowledge base of Adverse Drug Events using semantic web technology.

    Science.gov (United States)

    Jiang, Guoqian; Solbrig, Harold R; Chute, Christopher G

    2011-01-01

    A source of semantically coded Adverse Drug Event (ADE) data can be useful for identifying common phenotypes related to ADEs. We proposed a comprehensive framework for building a standardized ADE knowledge base (called ADEpedia) through combining ontology-based approach with semantic web technology. The framework comprises four primary modules: 1) an XML2RDF transformation module; 2) a data normalization module based on NCBO Open Biomedical Annotator; 3) a RDF store based persistence module; and 4) a front-end module based on a Semantic Wiki for the review and curation. A prototype is successfully implemented to demonstrate the capability of the system to integrate multiple drug data and ontology resources and open web services for the ADE data standardization. A preliminary evaluation is performed to demonstrate the usefulness of the system, including the performance of the NCBO annotator. In conclusion, the semantic web technology provides a highly scalable framework for ADE data source integration and standard query service.

  1. New progress in wastewater treatment technology for standard-reaching discharge in sour gas fields

    Directory of Open Access Journals (Sweden)

    Jie Yang

    2018-02-01

    Full Text Available Gas field water is generally characterized by complex contaminant components and high salinity. Its proper treatment has always been the great concern in the field of environmental protection of oil & gas fields. In this paper, the wastewater from a gas field in the Sichuan Basin with high salinity and more contaminants (e.g. sulfides was treated as a case study for the standard-reaching discharge. Lab experiments were carried out to analyze the adaptability and effectiveness of coagulation–desulfurization composite treatment technology, chemical oxidation based ammonia nitrogen removal technology and cryogenic multi-efficacy distillation technology in the treatment of wastewater in this field. The results show that the removal rate of sulfides and oils is over 90% if polymeric ferric sulfate (PFS is taken as the coagulant combined with TS-1 desulfurization agent. Besides, the removal rate of ammonia nitrogen is over 96% if CA-1 is taken as the oxidant. Finally, after the gas field water is treated by means of cryogenic three-efficacy distillation technology, chloride concentration of distilled water is below 150 mg/L and CODcr concentration is less than 60 mg/L. It is concluded that after the whole process treatment, the main contaminant indicators of wastewater in this case study can satisfy the grade one standard specified in the Integrated Wastewater Discharge Standard (GB 8978–1996 and the chloride concentration can meet the requirement of the Standards for Irrigation Water Quality (GB 5084–2005. To sum up, the above mentioned composite technologies are efficient to the wastewater treatment in sour gas fields. Keywords: Sulfide-bearing gas field water, Coagulation, Desulfurization, Chemical oxidation, Standard discharge, Ammonia nitrogen, Chloride, Cryogenic multi-efficacy distillation, Sichuan Basin

  2. Technology Validation: Fuel Cell Bus Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, Leslie [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-01-02

    This presentation describing the FY 2016 accomplishments for the National Renewable Energy Laboratory's Fuel Cell Bus Evaluations project was presented at the U.S. Department of Energy Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting, June 7, 2016.

  3. Advances in solar cell welding technology

    Energy Technology Data Exchange (ETDEWEB)

    Chidester, L.G.; Lott, D.R.

    1982-09-01

    In addition to developing the rigid substrate welded conventional cell panels for an earlier U.S. flight program, LMSC recently demonstrated a welded lightweight array system using both 2 x 4 and 5.9 x 5.9 cm wraparound solar cells. This weld system uses infrared sensing of weld joint temperature at the cell contact metalization interface to precisely control weld energy on each joint. Modules fabricated using this weld control system survived lowearth-orbit simulated 5-year tests (over 30,000 cycles) without joint failure. The data from these specifically configured modules, printed circuit substrate with copper interconnect and dielectric wraparound solar cells, can be used as a basis for developing weld schedules for additional cell array panel types.

  4. Mechanical Design of the LHC Standard Half-Cell

    Science.gov (United States)

    Poncet, A.; Brunet, J. C.; Cruikshank, P.; Genet, M.; Parma, V.; Rohmig, P.; Saban, R.; Tavian, L.; Veness, R.; Vlogaert, J.; Williams, L. R.

    1997-05-01

    The LHC Conceptual Design Report issued on 20th October 1995 (CERN/AC/95-05 (LHC) - nicknamed "Yellow Book") introduced significant changes to some fundamental features of the LHC standard half-cell, composed of one quadrupole, 3 dipoles and a set of corrector magnets. A separate cryogenic distribution line was introduced, which was previously inside the main cryostat. The dipole length has been increased from 10 to 15 m and independent powering of the focusing and defocusing quadrupole magnets was chosen. Individual quench protection diodes were introduced in magnets interconnects and many auxiliary bus bars were added to feed in series the various families of correcting superconducting magnets. The various highly intricate basic systems such as: cryostats and cryogenics feeders, superconducting magnets and their electrical feeding and protection, vacuum beam screen and its cooling, support and alignment devices have been redesigned, taking into account the very tight space available. These space constraints are given by the necessity to have maximum integral bending field strength for maximum LHC energy, and the existing LHC tunnel. Finally, cryogenic and vacuum sectorisation have been introduced to reduce downtimes and facilitate commissioning.

  5. Influence of modulation frequency in rubidium cell frequency standards

    Science.gov (United States)

    Audoin, C.; Viennet, J.; Cyr, N.; Vanier, J.

    1983-01-01

    The error signal which is used to control the frequency of the quartz crystal oscillator of a passive rubidium cell frequency standard is considered. The value of the slope of this signal, for an interrogation frequency close to the atomic transition frequency is calculated and measured for various phase (or frequency) modulation waveforms, and for several values of the modulation frequency. A theoretical analysis is made using a model which applies to a system in which the optical pumping rate, the relaxation rates and the RF field are homogeneous. Results are given for sine-wave phase modulation, square-wave frequency modulation and square-wave phase modulation. The influence of the modulation frequency on the slope of the error signal is specified. It is shown that the modulation frequency can be chosen as large as twice the non-saturated full-width at half-maximum without a drastic loss of the sensitivity to an offset of the interrogation frequency from center line, provided that the power saturation factor and the amplitude of modulation are properly adjusted.

  6. Next Generation Fuel Cell Technology for Passenger Cars and Buses

    OpenAIRE

    Mohrdieck, Dr.

    2009-01-01

    Daimler is presenting its latest fuel cell vehicle, the Mercedes-Benz B-Class F-CELL in 2009. Being one of the first series-produced fuel cell vehicles so far, the B-Class F-CELL will be a milestone on the road to commercialization of hydrogen-powered fuel cell vehicles. Equipped with advanced fuel cell technology it is suited for everyday operation and designed to fully meet customers´ expectations. From 2010 onwards, this zero emission vehicle is going to be operated by selected customers i...

  7. An Examination of Secondary School Teachers' Technology Integration Recommended by ISTE's National Educational Technology Standards for Teachers and School Principal Support for Teacher Technology Efforts

    Science.gov (United States)

    Esposito, Maria

    2013-01-01

    The National Educational Technology Standards for teachers (NETS-T) was adopted by New York State, and was critical to the development of students entering a global society. This study examines teachers' use of digital tools to promote student learning and reflection, promote digital citizenship, communicate and collaborate with parents and…

  8. Genome editing: a robust technology for human stem cells.

    Science.gov (United States)

    Chandrasekaran, Arun Pandian; Song, Minjung; Ramakrishna, Suresh

    2017-09-01

    Human pluripotent stem cells comprise induced pluripotent and embryonic stem cells, which have tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. Genome editing of stem cells is possible with the help of synthetic nucleases that facilitate site-specific modification of a gene of interest. Recent advances in genome editing techniques have improved the efficiency and speed of the development of stem cells for human disease models. Zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system are powerful tools for editing DNA at specific loci. Here, we discuss recent technological advances in genome editing with site-specific nucleases in human stem cells.

  9. Radball Technology Testing For Hot Cell Characterization

    International Nuclear Information System (INIS)

    Farfan, E.; Jannik, T.

    2010-01-01

    Operations at various U.S. Department of Energy sites have resulted in substantial radiological contamination of tools, equipment, and facilities. It is essential to use remote technologies for characterization and decommissioning to keep worker exposures as low as reasonably achievable in these highly contaminated environments. A significant initial step in planning and implementing D and D of contaminated facilities involves the development of an accurate assessment of the radiological, chemical, and structural conditions inside of the facilities. Collected information describing facility conditions using remote technologies could reduce the conservatism associated with planning initial worker entry (and associated cost).

  10. Microbial fuel cell: A green technology

    International Nuclear Information System (INIS)

    Jong Bor Chyan; Liew Pauline Woan Ying; Muhamad Lebai Juri; Ahmad Zainuri Mohd Dzomir; Leo Kwee Wah; Mat Rasol Awang

    2010-01-01

    Microbial Fuel Cell (MFC) was developed which was able to generate bio energy continuously while consuming wastewater containing organic matters. Even though the bio energy generated is not as high as hydrogen fuel cell, the MFC demonstrated great potential in bio-treating wastewater while using it as fuel source. Thus far, the dual-ability of the MFC to generate bio energy and bio-treating organic wastewater has been examined successfully using synthetic acetate and POME wastewaters. (author)

  11. Environmental aspects of battery and fuel cell technologies

    Energy Technology Data Exchange (ETDEWEB)

    1992-10-01

    The PA Consulting Group was commissioned by the Longer Term Studies Unit, Research and Technology Policy Division and Information and Manufacturing Technologies Division, Dept. of Trade and Industry to investigate possible environmental initiatives which might be driven by the European Commission and which could promote interest in alternative energy sources, particularly batteries and fuel cells. Findings confirmed that there is a role for fuel cells in power generation, the most commercially advanced technology being the phosphoric acid fuel cell (PAFC). Development of other systems such as Proton Exchange Membrane technology (PEMFC) and solid oxide fuel cells (SOFC) should also continue. Emissions from fuel cells are lower than those of gas turbines, their main competitors for power generation applications below 100 MW. The study concluded that there is a role for both batteries or fuel cells in powering electric vehicles. Battery powered retrofitted vehicles have an environmental impact comparable to that of internal combustion engine powered vehicles and they could become commercially viable in the context of a carbon tax scenario. Purpose built electric vehicles would be even more attractive. From an environmental viewpoint, fuels cells based on proton membrane membrane technology seemed the best option for powering vehicles if the technical targets could be met.

  12. Leveraging electronic healthcare record standards and semantic web technologies for the identification of patient cohorts.

    Science.gov (United States)

    Fernández-Breis, Jesualdo Tomás; Maldonado, José Alberto; Marcos, Mar; Legaz-García, María del Carmen; Moner, David; Torres-Sospedra, Joaquín; Esteban-Gil, Angel; Martínez-Salvador, Begoña; Robles, Montserrat

    2013-12-01

    The secondary use of electronic healthcare records (EHRs) often requires the identification of patient cohorts. In this context, an important problem is the heterogeneity of clinical data sources, which can be overcome with the combined use of standardized information models, virtual health records, and semantic technologies, since each of them contributes to solving aspects related to the semantic interoperability of EHR data. To develop methods allowing for a direct use of EHR data for the identification of patient cohorts leveraging current EHR standards and semantic web technologies. We propose to take advantage of the best features of working with EHR standards and ontologies. Our proposal is based on our previous results and experience working with both technological infrastructures. Our main principle is to perform each activity at the abstraction level with the most appropriate technology available. This means that part of the processing will be performed using archetypes (ie, data level) and the rest using ontologies (ie, knowledge level). Our approach will start working with EHR data in proprietary format, which will be first normalized and elaborated using EHR standards and then transformed into a semantic representation, which will be exploited by automated reasoning. We have applied our approach to protocols for colorectal cancer screening. The results comprise the archetypes, ontologies, and datasets developed for the standardization and semantic analysis of EHR data. Anonymized real data have been used and the patients have been successfully classified by the risk of developing colorectal cancer. This work provides new insights in how archetypes and ontologies can be effectively combined for EHR-driven phenotyping. The methodological approach can be applied to other problems provided that suitable archetypes, ontologies, and classification rules can be designed.

  13. Leveraging electronic healthcare record standards and semantic web technologies for the identification of patient cohorts

    Science.gov (United States)

    Fernández-Breis, Jesualdo Tomás; Maldonado, José Alberto; Marcos, Mar; Legaz-García, María del Carmen; Moner, David; Torres-Sospedra, Joaquín; Esteban-Gil, Angel; Martínez-Salvador, Begoña; Robles, Montserrat

    2013-01-01

    Background The secondary use of electronic healthcare records (EHRs) often requires the identification of patient cohorts. In this context, an important problem is the heterogeneity of clinical data sources, which can be overcome with the combined use of standardized information models, virtual health records, and semantic technologies, since each of them contributes to solving aspects related to the semantic interoperability of EHR data. Objective To develop methods allowing for a direct use of EHR data for the identification of patient cohorts leveraging current EHR standards and semantic web technologies. Materials and methods We propose to take advantage of the best features of working with EHR standards and ontologies. Our proposal is based on our previous results and experience working with both technological infrastructures. Our main principle is to perform each activity at the abstraction level with the most appropriate technology available. This means that part of the processing will be performed using archetypes (ie, data level) and the rest using ontologies (ie, knowledge level). Our approach will start working with EHR data in proprietary format, which will be first normalized and elaborated using EHR standards and then transformed into a semantic representation, which will be exploited by automated reasoning. Results We have applied our approach to protocols for colorectal cancer screening. The results comprise the archetypes, ontologies, and datasets developed for the standardization and semantic analysis of EHR data. Anonymized real data have been used and the patients have been successfully classified by the risk of developing colorectal cancer. Conclusions This work provides new insights in how archetypes and ontologies can be effectively combined for EHR-driven phenotyping. The methodological approach can be applied to other problems provided that suitable archetypes, ontologies, and classification rules can be designed. PMID:23934950

  14. Information technology-based standardized patient education in psychiatric inpatient care.

    Science.gov (United States)

    Anttila, Minna; Koivunen, Marita; Välimäki, Maritta

    2008-10-01

    This paper is a report of a study to describe nurses' experiences of information technology-based standardized patient education in inpatient psychiatric care. Serious mental health problems are an increasing global concern. Emerging evidence supports the implementation of practices that are conducive to patient self-management and improved patient outcomes among chronically ill patients with mental health problems. In contrast, the attitude of staff towards information technology has been reported to be contradictory in mental health care. After 1 year of using an Internet-based portal (Mieli.Net) developed for patients with schizophrenia spectrum psychosis, all 89 participating nurses were asked to complete questionnaires about their experiences. The data were collected in 2006. Fifty-six participants (63%) returned completed questionnaires and the data were analysed using content analysis. Nurses' experiences of the information technology-based standardized patient education were categorized into two major categories describing the advantages and obstacles in using information technology. Nurses thought that it brought the patients and nurses closer to each other and helped nurses to provide individual support for their patients. However, the education was time-consuming. Systematic patient education using information technology is a promising method of patient-centred care which supports nurses in their daily work. However, it must fit in with clinical activities, and nurses need some guidance in understanding its benefits. The study data can be used in policy-making when developing methods to improve the transparency of information provision in psychiatric nursing.

  15. Development of New Technologies for Stem Cell Research

    Directory of Open Access Journals (Sweden)

    Xibo Ma

    2012-01-01

    Full Text Available Since the 1960s, the stem cells have been extensively studied including embryonic stem cells, neural stem cells, bone marrow hematopoietic stem cells, and mesenchymal stem cells. In the recent years, several stem cells have been initially used in the treatment of diseases, such as in bone marrow transplant. At the same time, isolation and culture experimental technologies for stem cell research have been widely developed in recent years. In addition, molecular imaging technologies including optical molecular imaging, positron emission tomography, single-photon emission computed tomography, and computed tomography have been developed rapidly in recent the 10 years and have also been used in the research on disease mechanism and evaluation of treatment of disease related with stem cells. This paper will focus on recent typical isolation, culture, and observation techniques of stem cells followed by a concise introduction. Finally, the current challenges and the future applications of the new technologies in stem cells are given according to the understanding of the authors, and the paper is then concluded.

  16. Strategies for fuel cell product development. Developing fuel cell products in the technology supply chain

    International Nuclear Information System (INIS)

    Hellman, H.L.

    2004-01-01

    Due to the high cost of research and development and the broad spectrum of knowledge and competences required to develop fuel cell products, many product-developing firms outsource fuel cell technology, either partly or completely. This article addresses the inter-firm process of fuel cell product development from an Industrial Design Engineering perspective. The fuel cell product development can currently be characterised by a high degree of economic and technical uncertainty. Regarding the technology uncertainty: product-developing firms are more often then not unfamiliar with fuel cell technology technology. Yet there is a high interface complexity between the technology supplied and the product in which it is to be incorporated. In this paper the information exchange in three current fuel cell product development projects is analysed to determine the information required by a product designer to develop a fuel cell product. Technology transfer literature suggests that transfer effectiveness is greatest when the type of technology (technology uncertainty) and the type of relationship between the technology supplier and the recipient are carefully matched. In this line of thinking this paper proposes that the information required by a designer, determined by the design strategy and product/system volume, should be met by an appropriate level of communication interactivity with a technology specialist. (author)

  17. Demonstration of Passive Fuel Cell Thermal Management Technology

    Science.gov (United States)

    Burke, Kenneth A.; Jakupca, Ian; Colozza, Anthony; Wynne, Robert; Miller, Michael; Meyer, Al; Smith, William

    2012-01-01

    The NASA Glenn Research Center is developing advanced passive thermal management technology to reduce the mass and improve the reliability of space fuel cell systems for the NASA Exploration program. The passive thermal management system relies on heat conduction within highly thermally conductive cooling plates to move the heat from the central portion of the cell stack out to the edges of the fuel cell stack. Using the passive approach eliminates the need for a coolant pump and other cooling loop components within the fuel cell system which reduces mass and improves overall system reliability. Previous development demonstrated the performance of suitable highly thermally conductive cooling plates and integrated heat exchanger technology to collect the heat from the cooling plates (Ref. 1). The next step in the development of this passive thermal approach was the demonstration of the control of the heat removal process and the demonstration of the passive thermal control technology in actual fuel cell stacks. Tests were run with a simulated fuel cell stack passive thermal management system outfitted with passive cooling plates, an integrated heat exchanger and two types of cooling flow control valves. The tests were run to demonstrate the controllability of the passive thermal control approach. Finally, successful demonstrations of passive thermal control technology were conducted with fuel cell stacks from two fuel cell stack vendors.

  18. Plant cell technologies in space: Background, strategies and prospects

    Science.gov (United States)

    Kirkorian, A. D.; Scheld, H. W.

    1987-01-01

    An attempt is made to summarize work in plant cell technologies in space. The evolution of concepts and the general principles of plant tissue culture are discussed. The potential for production of high value secondary products by plant cells and differentiated tissue in automated, precisely controlled bioreactors is discussed. The general course of the development of the literature on plant tissue culture is highlighted.

  19. Effect of Induced Pluripotent Stem Cell Technology in Blood Banking

    Science.gov (United States)

    Focosi, Daniele

    2016-01-01

    Summary Population aging has imposed cost-effective alternatives to blood donations. Artificial blood is still at the preliminary stages of development, and the need for viable cells seems unsurmountable. Because large numbers of viable cells must be promptly available for clinical use, stem cell technologies, expansion, and banking represent ideal tools to ensure a regular supply. Provided key donors can be identified, induced pluripotent stem cell (iPSC) technology could pave the way to a new era in transfusion medicine, just as it is already doing in many other fields of medicine. The present review summarizes the current state of research on iPSC technology in the field of blood banking, highlighting hurdles, and promises. Significance The aging population in Western countries is causing a progressive reduction of blood donors and a constant increase of blood recipients. Because blood is the main therapeutic option to treat acute hemorrhage, cost-effective alternatives to blood donations are being actively investigated. The enormous replication capability of induced pluripotent stem cells and their promising results in many other fields of medicine could be an apt solution to produce the large numbers of viable cells required in transfusion and usher in a new era in transfusion medicine. The present report describes the potentiality, technological hurdles, and promises of induced pluripotent stem cells to generate red blood cells by redifferentiation. PMID:26819256

  20. Evaluation of technological and economic standard of the mining industry. [USSR

    Energy Technology Data Exchange (ETDEWEB)

    Evdokimov, F.I.; Nekhaev, S.A.; Laptev, I.V.

    1983-02-01

    In order to assure constant growth in coal production, as stipulated in the five-year plan, an evaluation scheme has been devised. The technological and economic standard is judged by indicators such as productivity, self sufficiency, capital write-off and investment, as well as factors such as working conditions, financial incentives, health services, and absenteeism. The method of canonical analysis yields expressions for technological and economic factors, and a coefficient for the utilization of resources. Relationship of these coefficients and factors is demonstrated graphically.

  1. Review and evaluation of technology, equipment, codes and standards for digitization of industrial radiographic film

    International Nuclear Information System (INIS)

    1992-05-01

    This reports contains a review and evaluation of the technology, equipment, and codes and standards related to the digitization of industrial radiographic film. The report presents recommendations and equipment-performance specifications that will allow the digitization of radiographic film from nuclear power plant components in order to produce faithful reproductions of flaw images of interest on the films. Justification for the specifications selected are provided. Performance demonstration tests for the digitization process are required and criteria for such tests is presented. Also several comments related to implementation of the technology are presented and discussed

  2. Hybrid tooling technologies and standardization for the manufacturing of inserts for micro injection molding

    DEFF Research Database (Denmark)

    Tosello, Guido; Fillon, Bertrand; Azcarate, Sabino

    2007-01-01

    This paper is based on the European Platform’s activities within the 4M Network of Excellence “Multi-Material Micro Manufacturing”. To overpass limitations of the current existing micro tooling capabilities, a new generation of micro hybrid tooling technologies for micro replication was developed....... A metrological approach was applied to standardize the employed tooling processes (micro milling, µEDM, laser micromachining, electrochemical µ-milling). The micro tools were then tested with different polymers (PP, PP + nano fillers, PC, COC). The paper provides a comparison of these technologies concerning...

  3. Selection and Evaluation of Priority Domains in Global Energy Internet Standard Development Based on Technology Foresight

    Science.gov (United States)

    Jin, Yang; Ciwei, Gao; Jing, Zhang; Min, Sun; Jie, Yu

    2017-05-01

    The selection and evaluation of priority domains in Global Energy Internet standard development will help to break through limits of national investment, thus priority will be given to standardizing technical areas with highest urgency and feasibility. Therefore, in this paper, the process of Delphi survey based on technology foresight is put forward, the evaluation index system of priority domains is established, and the index calculation method is determined. Afterwards, statistical method is used to evaluate the alternative domains. Finally the top four priority domains are determined as follows: Interconnected Network Planning and Simulation Analysis, Interconnected Network Safety Control and Protection, Intelligent Power Transmission and Transformation, and Internet of Things.

  4. Recommendation of standardized health learning contents using archetypes and semantic web technologies.

    Science.gov (United States)

    Legaz-García, María del Carmen; Martínez-Costa, Catalina; Menárguez-Tortosa, Marcos; Fernández-Breis, Jesualdo Tomás

    2012-01-01

    Linking Electronic Healthcare Records (EHR) content to educational materials has been considered a key international recommendation to enable clinical engagement and to promote patient safety. This would suggest citizens to access reliable information available on the web and to guide them properly. In this paper, we describe an approach in that direction, based on the use of dual model EHR standards and standardized educational contents. The recommendation method will be based on the semantic coverage of the learning content repository for a particular archetype, which will be calculated by applying semantic web technologies like ontologies and semantic annotations.

  5. Cell-based therapy technology classifications and translational challenges

    Science.gov (United States)

    Mount, Natalie M.; Ward, Stephen J.; Kefalas, Panos; Hyllner, Johan

    2015-01-01

    Cell therapies offer the promise of treating and altering the course of diseases which cannot be addressed adequately by existing pharmaceuticals. Cell therapies are a diverse group across cell types and therapeutic indications and have been an active area of research for many years but are now strongly emerging through translation and towards successful commercial development and patient access. In this article, we present a description of a classification of cell therapies on the basis of their underlying technologies rather than the more commonly used classification by cell type because the regulatory path and manufacturing solutions are often similar within a technology area due to the nature of the methods used. We analyse the progress of new cell therapies towards clinical translation, examine how they are addressing the clinical, regulatory, manufacturing and reimbursement requirements, describe some of the remaining challenges and provide perspectives on how the field may progress for the future. PMID:26416686

  6. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-09-01

    This FY 2011 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  7. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2013

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-04-30

    This FY 2013 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Office and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  8. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2014

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-02-01

    This FY 2014 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Office and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  9. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program - 2012

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-09-01

    This FY 2012 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  10. Advances in polymer concrete technology for cell house components

    International Nuclear Information System (INIS)

    Lynch, P.

    2000-01-01

    The cell house environment is very challenging with regard to protection of the concrete structure and components against the corrosive effects of acid. Coating technology using Epoxy, Vinyl Ester and Polyurethane Polymers is available, to provide the necessary chemical and heat resistance. However, producing suitable POLYMER CONCRETE technology for pre-cast components, especially tanks and cells requires not only the correct POLYMER selection, but also significant know-how in mineral aggregate technology to achieve the desired performance properties. Furthermore, the POLYMER CONCRETE technology must enable the pre-caster to manufacture the components in a simple one-step procedure. This paper outlines the important aspects in formulating POLYMER CONCRETE, the performance properties that can be achieved and the practical issues relating to the cost effective pre-casting of tanks and cells in particular. (author)

  11. Applications of Laser Precisely Processing Technology in Solar Cells

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to the design method of laser resonator cavity, we optimized the primary parameters of resonator and utilized LD arrays symmetrically pumping manner to implementing output of the high-brightness laser in our laser cutter, then which was applied to precisely cutting the conductive film of CuInSe2 solar cells, the buried contact silicon solar cells' electrode groove, and perforating in wafer which is used to the emitter wrap through silicon solar cells. Laser processing precision was less than 40μm, the results have met solar cell's fabrication technology, and made finally the buried cells' conversion efficiency be improved from 18% to 21% .

  12. Ensuring safety of fuel cell applications and hydrogen refuelling. Legislation and standards; Polttokennosovellusten ja vetytankkauksen turvallisuuden varmistaminen. Saeaedoeksiae ja standardeja

    Energy Technology Data Exchange (ETDEWEB)

    Nissila, M.; Sarsama, J.

    2013-09-15

    Fuel cell technology is considered a promising alternative in terms of viable energy systems. The advantages of fuel cell systems include a good efficiency rate and the lack of harmful environmental emissions. Factors which may slow down the commercialisation of fuel cell technology, e.g. fuel cell vehicles, include the high price of hydrogen and the insufficiency of the infrastructure required for the distribution of hydrogen. A large proportion of major car manufacturers are committed to introducing fuel cell cars to the market by 2014-2016. In order to ensure a successful market introduction of fuel cell vehicles, this has to be aligned with the development of the necessary hydrogen infrastructure. In the early commercialisation stages of a new technology, it is important to give the public correct, justified and understandable information on the safety of the fuel cell applications, and also on the measures taken to ensure the safety of applications. A lack of necessary information, inaccurate perceptions and prejudices can have an adverse effect on the public acceptance of fuel cell applications. Hazards and potential accidents related to fuel cell systems are mainly associated with the flammable substances (e.g. hydrogen, methane) used as fuel, the high pressure of hydrogen, electrical hazards, and dangers concerning technical systems in general. The fuel cell applications reviewed in this publication are transport applications and stationary applications and the refuelling system of gaseous hydrogen. The publication concentrates on fuel cells using hydrogen as fuel. The publication gives an overview of how EU-legislation (mainly various directives) and Finnish legislation applies to fuel cell systems and applications, and what kind of safety requirements the legislation sets. In addition, a brief overview of safety standards concerning fuel cell systems and hydrogen refuelling is presented. (orig.)

  13. Capillary Electrophoretic Technologies for Single Cell Metabolomics

    Science.gov (United States)

    Lapainis, Theodore E.

    2009-01-01

    Understanding the functioning of the brain is hindered by a lack of knowledge of the full complement of neurotransmitters and neuromodulatory compounds. Single cell measurements aid in the discovery of neurotransmitters used by small subsets of neurons that would be diluted below detection limits or masked by ubiquitous compounds when working with…

  14. Models and standards for production systems integration: Technological process and documents

    Directory of Open Access Journals (Sweden)

    Lečić Danica

    2005-01-01

    Full Text Available Electronic business demands from production companies to collaborate with customers, suppliers and end users and start electronic manufacturing. To achieve this goal companies have to integrate their subsystems (Application to Application-A2A and they have to collaborate with their business partners (Business to Business - B2B. For this purpose models and unique standards for integration are necessary. In this paper, ebXML and OAGI specifications have been used to present metamodel process by UML class diagram and standardized model of document Working Order for technological process in the form of OAGI BOD XML document. Based on it, from an example, model of technological process is presented by activity diagram (DA in XML form and an appearance of document Working Order. Just as well, rules of transformation DA to XML are presented.

  15. Development of semiconductor ΔE-E detector chip using standard bipolar IC technology

    International Nuclear Information System (INIS)

    Mishra, Vijay; Kataria, S.K.

    2005-01-01

    A proposal has been made for developing silicon based AE-E detector chip which can be used as particle identifiers in nuclear physics experiments and also in several applications in nuclear industry scenario. The proposed development work employs standard bipolar IC fabrication technology of Bharat Electronics Ltd. and the deliverable products that emerge out will be very cost effective. The present paper discusses the concept, feasibility studies and systematic plan for fabrication, characterization and packaging of the proposed detectors. (author)

  16. SEU testing of a novel hardened register implemented using standard CMOS technology

    International Nuclear Information System (INIS)

    Monnier, T.; Roche, F.M.; Cosculluela, J.; Velazco, R.

    1999-01-01

    A novel memory structure, designed to tolerate SEU perturbations, has been implemented in registers and tested. The design was completed using a standard submicron nonradiation hardened CMOS technology. This paper presents the results of heavy ions tests which evidence the noticeable improvement of the SEU-robustness with an increased LET threshold and reduced cross-section, without significant impact to die real estate, write time, or power consumption

  17. Critical parameters affecting the design of high frequency transmission lines in standard CMOS technology

    KAUST Repository

    Al Attar, Talal

    2017-05-13

    Different structures of transmission lines were designed and fabricated in standard CMOS technology to estimate some critical parameters including the RMS value of the surface roughness and the loss tangent. The input impedances for frequencies up to 50 GHz were modeled and compared with measurements. The results demonstrated a strong correlation between the used model with the proposed coefficients and the measured results, attesting the robustness of the model and the reliability of the incorporated coefficients values.

  18. Critical parameters affecting the design of high frequency transmission lines in standard CMOS technology

    KAUST Repository

    Al Attar, Talal; Alshehri, Abdullah; Almansouri, Abdullah Saud Mohammed; Al-Turki, Abdullah Turki

    2017-01-01

    Different structures of transmission lines were designed and fabricated in standard CMOS technology to estimate some critical parameters including the RMS value of the surface roughness and the loss tangent. The input impedances for frequencies up to 50 GHz were modeled and compared with measurements. The results demonstrated a strong correlation between the used model with the proposed coefficients and the measured results, attesting the robustness of the model and the reliability of the incorporated coefficients values.

  19. Embedded Web Technology: Applying World Wide Web Standards to Embedded Systems

    Science.gov (United States)

    Ponyik, Joseph G.; York, David W.

    2002-01-01

    Embedded Systems have traditionally been developed in a highly customized manner. The user interface hardware and software along with the interface to the embedded system are typically unique to the system for which they are built, resulting in extra cost to the system in terms of development time and maintenance effort. World Wide Web standards have been developed in the passed ten years with the goal of allowing servers and clients to intemperate seamlessly. The client and server systems can consist of differing hardware and software platforms but the World Wide Web standards allow them to interface without knowing about the details of system at the other end of the interface. Embedded Web Technology is the merging of Embedded Systems with the World Wide Web. Embedded Web Technology decreases the cost of developing and maintaining the user interface by allowing the user to interface to the embedded system through a web browser running on a standard personal computer. Embedded Web Technology can also be used to simplify an Embedded System's internal network.

  20. California Diploma Project Technical Report II: Alignment Study--Alignment Study of the Health Sciences and Medical Technology Draft Standards and California's Exit Level Common Core State Standards

    Science.gov (United States)

    McGaughy, Charis; de Gonzalez, Alicia

    2012-01-01

    The California Department of Education is in the process of revising the Career and Technical Education (CTE) Model Curriculum Standards. The Educational Policy Improvement Center (EPIC) conducted an investigation of the draft version of the Health Sciences and Medical Technology Standards (Health Science). The purpose of the study is to…

  1. Stem cells technology: a powerful tool behind new brain treatments.

    Science.gov (United States)

    Duru, Lucienne N; Quan, Zhenzhen; Qazi, Talal Jamil; Qing, Hong

    2018-06-18

    Stem cell research has recently become a hot research topic in biomedical research due to the foreseen unlimited potential of stem cells in tissue engineering and regenerative medicine. For many years, medicine has been facing intense challenges, such as an insufficient number of organ donations that is preventing clinicians to fulfill the increasing needs. To try and overcome this regrettable matter, research has been aiming at developing strategies to facilitate the in vitro culture and study of stem cells as a tool for tissue regeneration. Meanwhile, new developments in the microfluidics technology brought forward emerging cell culture applications that are currently allowing for a better chemical and physical control of cellular microenvironment. This review presents the latest developments in stem cell research that brought new therapies to the clinics and how the convergence of the microfluidics technology with stem cell research can have positive outcomes on the fields of regenerative medicine and high-throughput screening. These advances will bring new translational solutions for drug discovery and will upgrade in vitro cell culture to a new level of accuracy and performance. We hope this review will provide new insights into the understanding of new brain treatments from the perspective of stem cell technology especially regarding regenerative medicine and tissue engineering.

  2. A development of solid oxide fuel cell technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Hee Chun; Lee, Chang Woo [Korea Electric Power Corp. (KEPCO), Taejon (Korea, Republic of). Research Center; Kim, Kwy Youl; Yoon, Moon Soo; Kim, Ho Ki; Kim, Young Sik; Mun, Sung In; Eom, Sung Wuk [Korea Electrotechnology Research Inst., Changwon (Korea, Republic of)

    1995-12-31

    Solid oxide fuel cell which was consisted of ceramics has high power density and is very simple in shape. The project named A development of SOFC(Solid Oxide Fuel Cell) technology is to develop the unit cell fabrication processing and to evaluate the unit cell of solid oxide full cell. In this project, a manufacturing process of cathode by citrate method and polymeric precursor methods were established. By using tape casting method, high density thin electrolyte was manufactured and has high performance. Unit cell composed with La{sub 17}Sr{sub 13}Mn{sub 3} as cathode, 8YSZ electrolyte and 50% NiYSZ anode had a performance of O.85 W/cm{sup 2} and recorded 510 hours operation time. On the basis of these results. 100 cm{sup 2} class unit cell will be fabricated and tests in next program (author). 59 refs., 120 figs.

  3. A development of solid oxide fuel cell technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Hee Chun; Lee, Chang Woo [Korea Electric Power Corp. (KEPCO), Taejon (Korea, Republic of). Research Center; Kim, Kwy Youl; Yoon, Moon Soo; Kim, Ho Ki; Kim, Young Sik; Mun, Sung In; Eom, Sung Wuk [Korea Electrotechnology Research Inst., Changwon (Korea, Republic of)

    1996-12-31

    Solid oxide fuel cell which was consisted of ceramics has high power density and is very simple in shape. The project named A development of SOFC(Solid Oxide Fuel Cell) technology is to develop the unit cell fabrication processing and to evaluate the unit cell of solid oxide full cell. In this project, a manufacturing process of cathode by citrate method and polymeric precursor methods were established. By using tape casting method, high density thin electrolyte was manufactured and has high performance. Unit cell composed with La{sub 17}Sr{sub 13}Mn{sub 3} as cathode, 8YSZ electrolyte and 50% NiYSZ anode had a performance of O.85 W/cm{sup 2} and recorded 510 hours operation time. On the basis of these results. 100 cm{sup 2} class unit cell will be fabricated and tests in next program (author). 59 refs., 120 figs.

  4. Recent progress in Si thin film technology for solar cells

    Science.gov (United States)

    Kuwano, Yukinori; Nakano, Shoichi; Tsuda, Shinya

    1991-11-01

    Progress in Si thin film technology 'specifically amorphous Si (a-Si) and polycrystalline Si (poly-Si) thin film' for solar cells is summarized here from fabrication method, material, and structural viewpoints. In addition to a-Si, primary results on poly-Si thin film research are discussed. Various applications for a-Si solar cells are mentioned, and consumer applications and a-Si solar cell photovoltaic systems are introduced. New product developments include see-through solar cells, solar cell roofing tiles, and ultra-light flexible solar cells. As for new systems, air conditioning equipment powered by solar cells is described. Looking to the future, the proposed GENESIS project is discussed.

  5. Red Blood Cell Count Automation Using Microscopic Hyperspectral Imaging Technology.

    Science.gov (United States)

    Li, Qingli; Zhou, Mei; Liu, Hongying; Wang, Yiting; Guo, Fangmin

    2015-12-01

    Red blood cell counts have been proven to be one of the most frequently performed blood tests and are valuable for early diagnosis of some diseases. This paper describes an automated red blood cell counting method based on microscopic hyperspectral imaging technology. Unlike the light microscopy-based red blood count methods, a combined spatial and spectral algorithm is proposed to identify red blood cells by integrating active contour models and automated two-dimensional k-means with spectral angle mapper algorithm. Experimental results show that the proposed algorithm has better performance than spatial based algorithm because the new algorithm can jointly use the spatial and spectral information of blood cells.

  6. Microbial electrolysis cells as innovative technology for hydrogen production

    International Nuclear Information System (INIS)

    Chorbadzhiyska, Elitsa; Hristov, Georgi; Mitov, Mario; Hubenova, Yolina

    2011-01-01

    Hydrogen production is becoming increasingly important in view of using hydrogen in fuel cells. However, most of the production of hydrogen so far comes from the combustion of fossil fuels and water electrolysis. Microbial Electrolysis Cell (MEC), also known as Bioelectrochemically Assisted Microbial Reactor, is an ecologically clean, renewable and innovative technology for hydrogen production. Microbial electrolysis cells produce hydrogen mainly from waste biomass assisted by various bacteria strains. The principle of MECs and their constructional elements are reviewed and discussed. Keywords: microbial Electrolysis Cells, hydrogen production, waste biomass purification

  7. Standard-Cell, Open-Architecture Power Conversion Systems

    National Research Council Canada - National Science Library

    Boroyevich, D; Wang, F; Lee, F. C; Odendaal, W. G; Edwards, S

    2005-01-01

    ...). This project was purposefully aimed to develop a standardized hierarchical design and analysis methodology for modular power electronics conversion systems using as basis the ISO/OSI seven-layer reference model...

  8. Technological development and prospect of alkaline fuel cells

    International Nuclear Information System (INIS)

    Meng Ni; Michael KH Leung; Dennis YC Leung

    2006-01-01

    This paper reviewed the technological development of alkaline fuel cell (AFC). Although the technology was popular in 1970's and 1980's, there has been a decline in AFC research over the past decade, mainly due to the poisoning of CO 2 . Continuous efforts have demonstrated that CO 2 concentration could be reduced to an acceptable level by a number of viable methods such as absorption, adsorption, electrochemical process, electrolyte circulation, use of liquid hydrogen, and use of solid anionic exchange membranes. Literature survey showed that AFC lifetime could achieve up to 5000 hours. In addition, the use of ammonia as a fuel for AFC was identified as a promising technology. Comparison between AFC and proton exchange membrane fuel cell (PEMFC) was presented to evaluate the AFC technology and its economics. The present review and assessment showed the promise of AFC for the coming hydrogen economy and sustainable development. (authors)

  9. Induced pluripotent stem cell technology: a decade of progress.

    Science.gov (United States)

    Shi, Yanhong; Inoue, Haruhisa; Wu, Joseph C; Yamanaka, Shinya

    2017-02-01

    Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC screens are in the pipeline and the first clinical trial using human iPSC-derived products has been initiated. In particular, the combination of human iPSC technology with recent developments in gene editing and 3D organoids makes iPSC-based platforms even more powerful in each area of their application, including precision medicine. In this Review, we discuss the progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, and consider the remaining challenges and the emerging opportunities in the field.

  10. Printing technologies for biomolecule and cell-based applications.

    Science.gov (United States)

    Ihalainen, Petri; Määttänen, Anni; Sandler, Niklas

    2015-10-30

    Biomolecules, such as enzymes, proteins and other biomacromolecules (polynucleotides, polypeptides, polysaccharides and DNA) that are immobilized on solid surfaces are relevant to many areas of science and technology. These functionalized surfaces have applications in biosensors, chromatography, diagnostic immunoassays, cell culturing, DNA microarrays and other analytical techniques. Printing technologies offer opportunities in this context. The main interests in printing biomolecules are in immobilizing them on surfaces for sensors and catalysts or for controlled delivery of protein-based drugs. Recently, there have been significant developments in the use of inkjet printing for dispensing of proteins, biomacromolecules and cells. This review discusses the use of roll-to-roll and inkjet printing technologies in manufacturing of biomolecule and cell-based applications. Copyright © 2015. Published by Elsevier B.V.

  11. Vehicle Technologies and Fuel Cell Technologies Program: Prospective Benefits Assessment Report for Fiscal Year 2016

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, T. S. [Argonne National Lab. (ANL), Argonne, IL (United States); Taylor, C. H. [TA Engineering, Inc., Catonsville, MD (United States); Moore, J. S. [TA Engineering, Inc., Catonsville, MD (United States); Ward, J. [United States Department of Energy, Washington, DC (United States). Office of Energy Efficiency and Renewable Energy

    2016-02-23

    Under a diverse set of programs, the Vehicle Technologies and Fuel Cell Technologies offices of DOE’s Office of Energy Efficiency and Renewable Energy invest in research, development, demonstration, and deployment of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies. This report estimates the benefits of successfully developing and deploying these technologies (a “Program Success” case) relative to a base case (the “No Program” case). The Program Success case represents the future with completely successful deployment of Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) technologies. The No Program case represents a future in which there is no contribution after FY 2016 by the VTO or FCTO to these technologies. The benefits of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies were estimated on the basis of differences in fuel use, primary energy use, and greenhouse gas (GHG) emissions from light-, medium- and heavy-duty vehicles, including energy and emissions from fuel production, between the base case and the Program Success case. Improvements in fuel economy of various vehicle types, growth in the stock of fuel cell vehicles and other advanced technology vehicles, and decreased GHG intensity of hydrogen production and delivery in the Program Success case over the No Program case were projected to result in savings in petroleum use and GHG emissions. Benefits were disaggregated by individual program technology areas, which included the FCTO program and the VTO subprograms of batteries and electric drives; advanced combustion engines; fuels and lubricants; materials (for reduction in vehicle mass, or “lightweighting”); and, for medium- and heavy-duty vehicles, reduction in rolling and aerodynamic resistance. Projections for the Program Success case indicate that by 2035, the average fuel economy of on-road, light-duty vehicle stock could be 47% to 76

  12. Advances in tubular solid oxide fuel cell technology

    Energy Technology Data Exchange (ETDEWEB)

    Singhal, S.C. [Westinghouse Electric Corp., Pittsburgh, PA (United States)

    1996-12-31

    The design, materials and fabrication processes for the earlier technology Westinghouse tubular geometry cell have been described in detail previously. In that design, the active cell components were deposited in the form of thin layers on a ceramic porous support tube (PST). The tubular design of these cells and the materials used therein have been validated by successful electrical testing for over 65,000 h (>7 years). In these early technology PST cells, the support tube, although sufficiently porous, presented an inherent impedance to air flow toward air electrode. In order to reduce such impedance to air flow, the wall thickness of the PST was first decreased from the original 2 mm (the thick-wall PST) to 1.2 mm (the thin-wall PST). The calcia-stabilized zirconia support tube has now been completely eliminated and replaced by a doped lanthanum manganite tube in state-of-the-art SOFCs. This doped lanthanum manganite tube is extruded and sintered to about 30 to 35 percent porosity, and serves as the air electrode onto which the other cell components are fabricated in thin layer form. These latest technology cells are designated as air electrode supported (AES) cells.

  13. 76 FR 13851 - National Emission Standards for Hazardous Air Pollutants: Mercury Emissions From Mercury Cell...

    Science.gov (United States)

    2011-03-14

    ... National Emission Standards for Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali...-5] RIN 2060-AN99 National Emission Standards for Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali Plants AGENCY: Environmental Protection Agency (EPA). ACTION: Supplemental...

  14. Engineered Nanostructured MEA Technology for Low Temperature Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Yimin

    2009-07-16

    The objective of this project is to develop a novel catalyst support technology based on unique engineered nanostructures for low temperature fuel cells which: (1) Achieves high catalyst activity and performance; (2) Improves catalyst durability over current technologies; and (3) Reduces catalyst cost. This project is directed at the development of durable catalysts supported by novel support that improves the catalyst utilization and hence reduce the catalyst loading. This project will develop a solid fundamental knowledge base necessary for the synthetic effort while at the same time demonstrating the catalyst advantages in Direct Methanol Fuel Cells (DMFCs).

  15. Safety standards, legislation and codes of practice for fuel cell manufacture and operation

    Energy Technology Data Exchange (ETDEWEB)

    Wilcox, C.P.

    1999-07-01

    This report examines safety standards, legislation and codes of practice for fuel cell manufacture and operation in the UK, Europe and internationally. Management of health and safety in the UK is discussed, and the characteristics of phosphoric acid (PAFC), proton exchange membrane (PEM), molten carbonate (MCFC), solid oxide (SOFC) fuel cells are described. Fuel cell power plant standards and manufacture in the UK, design and operational considerations, end of life disposal, automotive fuel cell system, and fuelling and vehicular concerns are explored, and standards, legislation and codes of practice are explained in the appendix.

  16. Development of exosome surface display technology in living human cells

    Energy Technology Data Exchange (ETDEWEB)

    Stickney, Zachary, E-mail: zstickney@scu.edu; Losacco, Joseph, E-mail: jlosacco@scu.edu; McDevitt, Sophie, E-mail: smmcdevitt@scu.edu; Zhang, Zhiwen, E-mail: zzhang@scu.edu; Lu, Biao, E-mail: blu2@scu.edu

    2016-03-25

    Surface display technology is an emerging key player in presenting functional proteins for targeted drug delivery and therapy. Although a number of technologies exist, a desirable mammalian surface display system is lacking. Exosomes are extracellular vesicles that facilitate cell–cell communication and can be engineered as nano-shuttles for cell-specific delivery. In this study, we report the development of a novel exosome surface display technology by exploiting mammalian cell secreted nano-vesicles and their trans-membrane protein tetraspanins. By constructing a set of fluorescent reporters for both the inner and outer surface display on exosomes at two selected sites of tetraspanins, we demonstrated the successful exosomal display via gene transfection and monitoring fluorescence in vivo. We subsequently validated our system by demonstrating the expected intracellular partitioning of reporter protein into sub-cellular compartments and secretion of exosomes from human HEK293 cells. Lastly, we established the stable engineered cells to harness the ability of this robust system for continuous production, secretion, and uptake of displayed exosomes with minimal impact on human cell biology. In sum, our work paved the way for potential applications of exosome, including exosome tracking and imaging, targeted drug delivery, as well as exosome-mediated vaccine and therapy.

  17. Development of exosome surface display technology in living human cells

    International Nuclear Information System (INIS)

    Stickney, Zachary; Losacco, Joseph; McDevitt, Sophie; Zhang, Zhiwen; Lu, Biao

    2016-01-01

    Surface display technology is an emerging key player in presenting functional proteins for targeted drug delivery and therapy. Although a number of technologies exist, a desirable mammalian surface display system is lacking. Exosomes are extracellular vesicles that facilitate cell–cell communication and can be engineered as nano-shuttles for cell-specific delivery. In this study, we report the development of a novel exosome surface display technology by exploiting mammalian cell secreted nano-vesicles and their trans-membrane protein tetraspanins. By constructing a set of fluorescent reporters for both the inner and outer surface display on exosomes at two selected sites of tetraspanins, we demonstrated the successful exosomal display via gene transfection and monitoring fluorescence in vivo. We subsequently validated our system by demonstrating the expected intracellular partitioning of reporter protein into sub-cellular compartments and secretion of exosomes from human HEK293 cells. Lastly, we established the stable engineered cells to harness the ability of this robust system for continuous production, secretion, and uptake of displayed exosomes with minimal impact on human cell biology. In sum, our work paved the way for potential applications of exosome, including exosome tracking and imaging, targeted drug delivery, as well as exosome-mediated vaccine and therapy.

  18. University energy management improvement on basis of standards and digital technologies

    Directory of Open Access Journals (Sweden)

    Novikova Olga

    2018-01-01

    Full Text Available Nowadays to implement the energy management system it is important to fulfill not only the legal requirements but also to follow the set of recommendations prepared by international and national management standards. The purpose of this article is to prepare the concept and methodology for the optimization and improvement of the energy management system (EMS for Universities with implementation of legal requirements and recommendations from international and national management standards with the help of digital technologies. During the research the systematic analysis, complex approach, logical sampling and analogy were used. It is shown that this process should be done with the help of the process-based approach, in accordance with ISO 9001, and energy management ISO 50001. The authors developed the structure of the basic standard of energy management: "Guidelines for the energy management system". It is proved that the involvement of the technical senior students in the project of EMS improvement allows to expand their competencies for new technics and technologies. Cloud service Bitrix24 was chosen for IT-support of the project. During the study, a list of characteristics was used as a basis for creating a query to the technology department of the university. DBMS Microsoft Access was chosen for its creation. In addition, the possible results of initiating a single database containing all the information needed for accounting and control of energy supply were listed. Moreover, the possibility of automated energy management system implementation and its results were considered. The required actions described in this research can be implemented in any University, that will extend energy management to any University worldwide.

  19. ISO 19157 standard application in technological process of the production of digital topographic maps

    Directory of Open Access Journals (Sweden)

    Drobnjak Siniša M.

    2014-01-01

    Full Text Available Standardization in the field of geographical information related to the definition of the system of collection, preparation, storage, maintenance, presentation and sharing of geographic information. Quality information of available spatial data are vital in the process of selecting a dataset where data value is directly related to its quality. Users of spatial data can choose data from multiple datasets. Therefore. It is necessary to compare the quality of datasets and determine which best meet customer requirements. Digital topographic maps for its visuality, brevity and easy of use have a big advantage over other spatial datasets and is therefore fully justified request for the development of the system of determining, evaluating and impart their quality. The main objective of this paper is to describe the possibilities of application of ISO 19157 'Geographic information - Data quality' standard in technological process of the production of digital topographic maps.

  20. A scheme for the audit of scientific and technological standards in clinical nuclear medicine

    International Nuclear Information System (INIS)

    Perkins, A.C.; Jarritt, P.H.

    2002-01-01

    Aim: Audit is the process whereby the quality of a service is monitored and optimised. It forms an essential component of the quality assurance process, whether by self-assessment or by external peer review. In the UK the British Nuclear Medicine Society (BNMS) has undertaken external organisational audit of departments providing clinical nuclear medicine services. This work aimed to develop a more thorough and service specific process for the audit of scientific and technological standards in nuclear medicine. Materials and Methods: The audit process has been implemented using written audit documents to facilitate the audit procedure. A questionnaire forms part of the formal documentation for audit of the scientific and technical standards of a clinical service. Scientific and technical standards were derived from a number of sources including legal requirements, regulatory obligations, notes for guidance, peer reviewed publications and accepted good clinical practice (GCP). Results: The audit process graded the standards of an individual department according to legal or safety requirements (Grade A), good practice (Grade B) and desirable aspects of service delivery (Grade C). The standards have been allocated into eight main categories. These are: Instrumentation; Software and data protection; Electrical Safety; Mechanical Safety; Workstation Safety; The Control of Substances Hazardous to Health (COSHH); Radiation Protection; Scientific and Technical staffing levels. During the audit visit a detailed inspection of clinical and laboratory areas and department written documentation is also necessary to validate the data obtained. Conclusion: The printed scheme now provides a means for external audit or self-assessment. There should be evidence of a well-organised and safe environment for both patients and staff. Health and Safety legislation requires written local rules and these records should be available to demonstrate the standard of service provision. Other

  1. Technology Innovations to Improve Biomass Cookstoves to Meet Tier 4 Standards

    Energy Technology Data Exchange (ETDEWEB)

    Still, Dean K [Aprovecho Research Center, Cottage Grove, OR (United States); Hatfield, Micheal S [Aprovecho Research Center, Cottage Grove, OR (United States)

    2015-12-15

    Technology Innovations to Improve Biomass Cookstoves to Meet Tier 4 Standards. Protecting public health has become a major motivation for investigating how improved cook stoves might function as a viable intervention. Currently, the great majority of cookstoves for sale in the developing world were not designed for this purpose but instead success was based on criteria such as reduced fuel use, affordability, and ease of use. With DOE funding Aprovecho Research Center spent three years creating stoves using an iterative development and modeling approach resulting in four stoves that in lab tests met the World Health Organization (2014) intermediate rate vented targets for PM2.5 and for CO.

  2. Nuclear reactors' construction costs: The role of lead-time, standardization and technological progress

    International Nuclear Information System (INIS)

    Berthélemy, Michel; Escobar Rangel, Lina

    2015-01-01

    This paper provides an econometric analysis of nuclear reactor construction costs in France and the United States based on overnight costs data. We build a simultaneous system of equations for overnight costs and construction time (lead-time) to control for endogeneity, using change in expected electricity demand as instrument. We argue that the construction of nuclear reactors can benefit from standardization gains through two channels. First, short term coordination benefits can arise when the diversity of nuclear reactors' designs under construction is low. Second, long term benefits can occur due to learning spillovers from past constructions of similar reactors. We find that construction costs benefit directly from learning spillovers but that these spillovers are only significant for nuclear models built by the same Architect–Engineer. In addition, we show that the standardization of nuclear reactors under construction has an indirect and positive effect on construction costs through a reduction in lead-time, the latter being one of the main drivers of construction costs. Conversely, we also explore the possibility of learning by searching and find that, contrary to other energy technologies, innovation leads to construction costs increases. -- Highlights: •This paper analyses the determinants of nuclear reactors construction costs and lead-time. •We study short term (coordination gains) and long term (learning by doing) benefits of standardization in France and the US. •Results show that standardization of nuclear programs is a key factor for reducing construction costs. •We also suggest that technological progress has contributed to construction costs escalation

  3. RADISH SEED PRODUCTION (TRANSPLANTATION CULTURE; STANDARD OF ORGANISATION FOR MODEL TECHNOLOGICAL PROCESS

    Directory of Open Access Journals (Sweden)

    L. V. Pavlov

    2016-01-01

    Full Text Available The standard of organization for model technological process of seed production waselaborated at VNIISSOK. Requirements established are for implementation of technological operation at radish seed production as transplantation culture as followed: seed plant growing in polyhouses to produce elite seeds, seedlings planting out, plant nursing, harvesting and postharvest processing. The standard is aimed to provide the qualified work in radish seed production through transplantation culture. Radish seed plants for elite seed production are grown on warmed soil beds in winter greenhouses with use of plastic roofing or in plastic houses supplied with heating system. Seeds with germination not less than 85 % according to GOST 32592-2013 are taken for seed production aims. Hand sowing under marker ensures the identical all-around nutrition for plants that is particularly important when growing and selecting the seed plants (1 hectare - 55-60 thousand seed plant roots. Approbation of seed plants is carried out just before harvesting. The terms of seed plant planting are the earliest. Scheme of planting is 70 x 15 - 20 (cm, 60 x 30 (cm or 90 x 15 (cm. To protect the seed production plantation of radish against weeds, diseases and pests, the pesticides are allowed to apply in accordance with State Catalogue of Pesticides and Agrochemicals, permitted to use in the territory of Russian Federation. Postharvest desiccation of seed plants enables to yield radish by means of direct combining. Radish seeds after processing on sowing qualities have to meet all sowing requirements according to the acting standard. The standard of organization is agreed and affirmed in 2016 CTO45727225-52-16.

  4. Use of Open Standards and Technologies at the Lunar Mapping and Modeling Project

    Science.gov (United States)

    Law, E.; Malhotra, S.; Bui, B.; Chang, G.; Goodale, C. E.; Ramirez, P.; Kim, R. M.; Sadaqathulla, S.; Rodriguez, L.

    2011-12-01

    The Lunar Mapping and Modeling Project (LMMP), led by the Marshall Space Flight center (MSFC), is tasked by NASA. The project is responsible for the development of an information system to support lunar exploration activities. It provides lunar explorers a set of tools and lunar map and model products that are predominantly derived from present lunar missions (e.g., the Lunar Reconnaissance Orbiter (LRO)) and from historical missions (e.g., Apollo). At Jet Propulsion Laboratory (JPL), we have built the LMMP interoperable geospatial information system's underlying infrastructure and a single point of entry - the LMMP Portal by employing a number of open standards and technologies. The Portal exposes a set of services to users to allow search, visualization, subset, and download of lunar data managed by the system. Users also have access to a set of tools that visualize, analyze and annotate the data. The infrastructure and Portal are based on web service oriented architecture. We designed the system to support solar system bodies in general including asteroids, earth and planets. We employed a combination of custom software, commercial and open-source components, off-the-shelf hardware and pay-by-use cloud computing services. The use of open standards and web service interfaces facilitate platform and application independent access to the services and data, offering for instances, iPad and Android mobile applications and large screen multi-touch with 3-D terrain viewing functions, for a rich browsing and analysis experience from a variety of platforms. The web services made use of open standards including: Representational State Transfer (REST); and Open Geospatial Consortium (OGC)'s Web Map Service (WMS), Web Coverage Service (WCS), Web Feature Service (WFS). Its data management services have been built on top of a set of open technologies including: Object Oriented Data Technology (OODT) - open source data catalog, archive, file management, data grid framework

  5. Efficiency Enhancement of Silicon Solar Cells by Porous Silicon Technology

    Directory of Open Access Journals (Sweden)

    Eugenijus SHATKOVSKIS

    2012-09-01

    Full Text Available Silicon solar cells produced by a usual technology in p-type, crystalline silicon wafer were investigated. The manufactured solar cells were of total thickness 450 mm, the junction depth was of 0.5 mm – 0.7 mm. Porous silicon technologies were adapted to enhance cell efficiency. The production of porous silicon layer was carried out in HF: ethanol = 1 : 2 volume ratio electrolytes, illuminating by 50 W halogen lamps at the time of processing. The etching current was computer-controlled in the limits of (6 ÷ 14 mA/cm2, etching time was set in the interval of (10 ÷ 20 s. The characteristics and performance of the solar cells samples was carried out illuminating by Xenon 5000 K lamp light. Current-voltage characteristic studies have shown that porous silicon structures produced affect the extent of dark and lighting parameters of the samples. Exactly it affects current-voltage characteristic and serial resistance of the cells. It has shown, the formation of porous silicon structure causes an increase in the electric power created of solar cell. Conversion efficiency increases also respectively to the initial efficiency of cell. Increase of solar cell maximum power in 15 or even more percent is found. The highest increase in power have been observed in the spectral range of Dl @ (450 ÷ 850 nm, where ~ 60 % of the A1.5 spectra solar energy is located. It has been demonstrated that porous silicon technology is effective tool to improve the silicon solar cells performance.DOI: http://dx.doi.org/10.5755/j01.ms.18.3.2428

  6. Legal status of minister's notices and technology standards of 'Korea institute of nuclear safety'(KINS) to regulate nuclear safety

    International Nuclear Information System (INIS)

    Jung, S. K.; Jung, M. M.; Kim, S. W.; Jang, K. H.; Oh, B. J.

    2003-01-01

    Concerning nuclear safety or technology standards, each of 'notices' issued by minister of science and technology(MOST) empowered by law of its regulation is obviously forceful as a law, if not all. But the standards made by the chief of Korea institute of nuclear safety(KINS) to meet the tasks entrusted to KINS by MOST is only conditionally forceful as a law, that is, on the condition that law or regulation empowered the chief of KINS to make nuclear safety and/or technology standards

  7. Technology channel fuel cells; Reseau technologique piles a combustible

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This document presents the PACo channel, its research and development program and the calendar of the first year. The PACo channel aims at stimulate the technology innovation in the domain of the fuel cells and organize collaborations between enterprises and research laboratories. (A.L.B.)

  8. Thin Cell Layer technology in ornamental plant micropropagation ...

    African Journals Online (AJOL)

    Thin cell layer (TCL) technology originated almost 30 years ago with the controlled development of flowers, roots, shoots and somatic embryos on tobacco pedicel longitudinal TCLs. Since then TCLs have been successfully used in the micropropagation of many ornamental plant species whose previous in vitro ...

  9. Assessing the quality of decision support technologies using the International Patient Decision Aid Standards instrument (IPDASi.

    Directory of Open Access Journals (Sweden)

    Glyn Elwyn

    Full Text Available To describe the development, validation and inter-rater reliability of an instrument to measure the quality of patient decision support technologies (decision aids.Scale development study, involving construct, item and scale development, validation and reliability testing.There has been increasing use of decision support technologies--adjuncts to the discussions clinicians have with patients about difficult decisions. A global interest in developing these interventions exists among both for-profit and not-for-profit organisations. It is therefore essential to have internationally accepted standards to assess the quality of their development, process, content, potential bias and method of field testing and evaluation.Scale development study, involving construct, item and scale development, validation and reliability testing.Twenty-five researcher-members of the International Patient Decision Aid Standards Collaboration worked together to develop the instrument (IPDASi. In the fourth Stage (reliability study, eight raters assessed thirty randomly selected decision support technologies.IPDASi measures quality in 10 dimensions, using 47 items, and provides an overall quality score (scaled from 0 to 100 for each intervention. Overall IPDASi scores ranged from 33 to 82 across the decision support technologies sampled (n = 30, enabling discrimination. The inter-rater intraclass correlation for the overall quality score was 0.80. Correlations of dimension scores with the overall score were all positive (0.31 to 0.68. Cronbach's alpha values for the 8 raters ranged from 0.72 to 0.93. Cronbach's alphas based on the dimension means ranged from 0.50 to 0.81, indicating that the dimensions, although well correlated, measure different aspects of decision support technology quality. A short version (19 items was also developed that had very similar mean scores to IPDASi and high correlation between short score and overall score 0.87 (CI 0.79 to 0.92.This work

  10. A parallel row-based algorithm for standard cell placement with integrated error control

    Science.gov (United States)

    Sargent, Jeff S.; Banerjee, Prith

    1989-01-01

    A new row-based parallel algorithm for standard-cell placement targeted for execution on a hypercube multiprocessor is presented. Key features of this implementation include a dynamic simulated-annealing schedule, row-partitioning of the VLSI chip image, and two novel approaches to control error in parallel cell-placement algorithms: (1) Heuristic Cell-Coloring; (2) Adaptive Sequence Length Control.

  11. Field Performance versus Standard Test Condition Efficiency of Tandem Solar Cells and the Specific Case of Perovskites/Silicon Devices

    KAUST Repository

    Dupre, Olivier

    2018-01-05

    Multijunction cells may offer a cost-effective route to boost the efficiency of industrial photovoltaics. For any technology to be deployed in the field, its performance under actual operating conditions is extremely important. In this perspective, we evaluate the impact of spectrum, light intensity, and module temperature variations on the efficiency of tandem devices with crystalline silicon bottom cells with a particular focus on perovskite top cells. We consider devices with different efficiencies and calculate their energy yields using field data from Denver. We find that annual losses due to differences between operating conditions and standard test conditions are similar for single-junction and four-terminal tandem devices. The additional loss for the two-terminal tandem configuration caused by current mismatch reduces its performance ratio by only 1.7% when an optimal top cell bandgap is used. Additionally, the unusual bandgap temperature dependence of perovskites is shown to have a positive, compensating effect on current mismatch.

  12. Manufacturing technologies for direct methanol fuel cells (DMFCs)

    Energy Technology Data Exchange (ETDEWEB)

    Gluesen, Andreas; Mueller, Martin; Kimiaie, Nicola; Konradi, Irene; Mergel, Juergen; Stolten, Detlef [Forschungszentrum Juelich (Germany). Inst. of Energy Research - IEF-3: Fuel Cells

    2010-07-01

    Fuel cell research is focussing on increasing power density and lifetime and reducing costs of the whole fuel cell system. In order to reach these aims, it is necessary to develop appropriately designed components outgoing from high quality materials, a suitable manufacturing process and a well balanced system. To make use of the advantages that can be obtained by developing production technology, we are mainly improving the coating and assembling techniques for polymer electrolyte fuel cells, especially Direct Methanol Fuel Cells (DMFCs). Coating is used for making fuel cell electrodes as well as highly conductive contacts. Assembling is used to join larger components like membrane electrode assemblies (MEAs) and bipolar units consisting of flow fields and the separator plate, as well as entire stacks. On the one hand a reproducible manufacturing process is required to study fine differences in fuel cell performance affected by new materials or new designs. On the other hand a change in each parameter of the manufacturing process itself can change product properties and therefore affect fuel cell performance. As a result, gas diffusion electrodes (GDEs) are now produced automatically in square-meter batches, the hot-pressing of MEAs is a fully automated process and by pre-assembling the number of parts that have to be assembled in a stack was reduced by a factor of 10. These achievements make DMFC manufacturing more reproducible and less error-prone. All these and further developments of manufacturing technology are necessary to make DMFCs ready for the market. (orig.)

  13. Proceedings of the 1999 Review Conference on Fuel Cell Technology

    Energy Technology Data Exchange (ETDEWEB)

    None Available

    2000-06-05

    The 1999 Review Conference on Fuel Cell Technology was jointly sponsored by the U.S. Department of Energy, Federal Energy Technology Center (FETC), the Gas Research Institute (GRI), and the Electric Power Research Institute (EPRI). It was held August 3 to 5 in Chicago, Illinois. The goal of this conference was to provide a forum for reviewing fuel cell research and development (R&D) programs, assist in strategic R&D planning, promote awareness of sponsor activities, and enhance interactions between manufacturers, researchers, and stakeholders. This conference was attended by over 250 representatives from industry, academia, national laboratories, gas and electric utilities, DOE, and other Government agencies. The conference agenda included a keynote session, five presentation sessions, a poster presentation reception, and three breakout sessions. The presentation session topics were DOD Fuel Cell Applications, Low-Temperature Fuel Cell Manufacturers, Low-Temperature Component Research, High-Temperature Fuel Cell Manufacturers, and High-Temperature Component Research; the breakout session topics were Future R&D Directions for Low-Temperature Fuel Cells, Future R&D Directions for High-Temperature Fuel Cells, and a plenary summary session. All sessions were well attended.

  14. AlliedSignal solid oxide fuel cell technology

    Energy Technology Data Exchange (ETDEWEB)

    Minh, N.; Barr, K.; Kelly, P.; Montgomery, K. [AlliedSignal Aerospace Equipment Systems, Torrance, CA (United States)

    1996-12-31

    AlliedSignal has been developing high-performance, lightweight solid oxide fuel cell (SOFC) technology for a broad spectrum of electric power generation applications. This technology is well suited for use in a variety of power systems, ranging from commercial cogeneration to military mobile power sources. The AlliedSignal SOFC is based on stacking high-performance thin-electrolyte cells with lightweight metallic interconnect assemblies to form a compact structure. The fuel cell can be operated at reduced temperatures (600{degrees} to 800{degrees}C). SOFC stacks based on this design has the potential of producing 1 kW/kg and 1 ML. This paper summarizes the technical status of the design, manufacture, and operation of AlliedSignal SOFCs.

  15. Recent Advances in Microbial Single Cell Genomics Technology and Applications

    Science.gov (United States)

    Stepanauskas, R.

    2016-02-01

    Single cell genomics is increasingly utilized as a powerful tool to decipher the metabolic potential, evolutionary histories and in situ interactions of environmental microorganisms. This transformative technology recovers extensive information from cultivation-unbiased samples of individual, unicellular organisms. Thus, it does not require data binning into arbitrary phylogenetic or functional groups and therefore is highly compatible with agent-based modeling approaches. I will present several technological advances in this field, which significantly improve genomic data recovery from individual cells and provide direct linkages between cell's genomic and phenotypic properties. I will also demonstrate how these new technical capabilities help understanding the metabolic potential and viral infections of the "microbial dark matter" inhabiting aquatic and subsurface environments.

  16. Nuclear reactors' construction costs: The role of lead-time, standardization and technological progress

    International Nuclear Information System (INIS)

    Berthelemy, Michel; Escobar Rangel, Lina

    2013-01-01

    This paper provides the first comparative analysis of nuclear reactor construction costs in France and the United States. Studying the cost of nuclear power has often been a challenge, owing to the lack of reliable data sources and heterogeneity between countries, as well as the long time horizon which requires controlling for input prices and structural changes. We build a simultaneous system of equations for overnight costs and construction time (lead-time) to control for endogeneity, using expected demand variation as an instrument. We argue that benefits from nuclear reactor program standardization can arise through short term coordination gains, when the diversity of nuclear reactors' technologies under construction is low, or through long term benefits from learning spillovers from past reactor construction experience, if those spillovers are limited to similar reactors. We find that overnight construction costs benefit directly from learning spillovers but that these spillovers are only significant for nuclear models built by the same Architect-Engineer (A- E). In addition, we show that the standardization of nuclear reactors under construction has an indirect and positive effect on construction costs through a reduction in lead-time, the latter being one of the main drivers of construction costs. Conversely, we also explore the possibility of learning by searching and find that, contrary to other energy technologies, innovation leads to construction costs increases. (authors)

  17. Technology transfer through a network of standard methods and recommended practices - The case of petrochemicals

    Science.gov (United States)

    Batzias, Dimitris F.; Karvounis, Sotirios

    2012-12-01

    Technology transfer may take place in parallel with cooperative action between companies participating in the same organizational scheme or using one another as subcontractor (outsourcing). In this case, cooperation should be realized by means of Standard Methods and Recommended Practices (SRPs) to achieve (i) quality of intermediate/final products according to specifications and (ii) industrial process control as required to guarantee such quality with minimum deviation (corresponding to maximum reliability) from preset mean values of representative quality parameters. This work deals with the design of the network of SRPs needed in each case for successful cooperation, implying also the corresponding technology transfer, effectuated through a methodological framework developed in the form of an algorithmic procedure with 20 activity stages and 8 decision nodes. The functionality of this methodology is proved by presenting the path leading from (and relating) a standard test method for toluene, as petrochemical feedstock in the toluene diisocyanate production, to the (6 generations distance upstream) performance evaluation of industrial process control systems (ie., from ASTM D5606 to BS EN 61003-1:2004 in the SRPs network).

  18. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A.; Brown, Scott A.

    2011-09-29

    The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). To do this, Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify hydrogen- and fuel-cell-related patents that are associated with FCT-funded projects (or projects conducted by DOE-EERE predecessor programs) and to ascertain the patents current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of hydrogen- and fuel-cell-related grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs, and within the FCT portfolio.

  19. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A.

    2012-09-28

    The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify patents related to hydrogen and fuel cells that are associated with FCT-funded projects (or projects conducted by DOE-EERE predecessor programs) and to ascertain the patents’ current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs that are related to hydrogen and fuel cells.

  20. The European ITER test blanket modules: Progress in development of fabrication technologies towards standardization

    Energy Technology Data Exchange (ETDEWEB)

    Zmitko, Milan, E-mail: milan.zmitko@f4e.europa.eu [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain); Thomas, Noël [ATMOSTAT, F-94815 Villejuif (France); LiPuma, Antonella; Forest, Laurent [CEA-Saclay, DEN, DM2S, SEMT, F-91191 Gif-sur-Yvette (France); Cogneau, Laurence [CEA-DRT, 38000 Grenoble (France); Rey, Jörg; Neuberger, Heiko [Karlsruhe Institute of Technology (KIT), Postfach 3640, Karlsruhe (Germany); Poitevin, Yves [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain)

    2016-11-01

    Highlights: • Significant progress on the development of welding procedures for European TBM achieved. • Fabrication processes feasibility based on diffusion and fusion welding demonstrated. • An optimized welding scenario/sequence for TBM box assembly identified. • Future qualification of pF/WPS proposed through realization of a number of QMUs. - Abstract: The paper reviews progress achieved in development of fabrication technologies and procedures applied for manufacturing of the TBM sub-components, like, HCLL and HCPB cooling plates, HCLL/HCPB stiffening plates, and HCLL/HCPB first wall and side caps. The used technologies are based on fusion and diffusion welding techniques taking into account specificities of the EUROFER97 steel. Development of a standardized procedure complying with professional codes and standards (RCC-MRx), a preliminary fabrication/welding procedure specification (pF/WPS), is described based on fabrication and non-destructive and destructive characterization of feasibility mock-ups (FMU) aimed at assessing the suitability of a fabrication process for fulfilling the design and fabrication specifications. The main FMUs characterization results are reported (e.g. pressure resistance and helium leak tightness tests, mechanical properties and microstructure at the weld joints, geometrical characteristics of the sub-components and internal cooling channels) and the key pF/WPS steps and parameters are outlined. Also, fabrication procedures for the TBM box assembly are presently under development for the establishment of an optimized assembly sequence/scenario and development of standardized welding procedure specifications. In conclusions, further steps towards the pF/WPS qualification are briefly discussed.

  1. Forward Technology Solar Cell Experiment First On-Orbit Data

    Science.gov (United States)

    Walters, R. J.; Garner, J. C.; Lam, S. N.; Vazquez, J. A.; Braun, W. R.; Ruth, R. E.; Warner, J. H.; Lorentzen, J. R.; Messenger, S. R.; Bruninga, R.; hide

    2007-01-01

    This paper presents first on orbit measured data from the Forward Technology Solar Cell Experiment (FTSCE). FTSCE is a space experiment housed within the 5th Materials on the International Space Station Experiment (MISSE-5). MISSE-5 was launched aboard the Shuttle return to flight mission (STS-114) on July 26, 2005 and deployed on the exterior of the International Space Station (ISS). The experiment will remain in orbit for nominally one year, after which it will be returned to Earth for post-flight testing and analysis. While on orbit, the experiment is designed to measure a 36 point current vs. voltage (IV) curve on each of the experimental solar cells, and the data is continuously telemetered to Earth. The experiment also measures the solar cell temperature and the orientation of the solar cells to the sun. A range of solar cell technologies are included in the experiment including state-of-the-art triple junction InGaP/GaAs/Ge solar cells from several vendors, thin film amorphous Si and CuIn(Ga)Se2 cells, and next-generation technologies like single-junction GaAs cells grown on Si wafers and metamorphic InGaP/InGaAs/Ge triple-junction cells. In addition to FTSCE, MISSE-5 also contains a Thin-Film Materials experiment. This is a passive experiment that will provide data on the effect of the space environment on more than 200 different materials. FTSCE was initially conceived in response to various on-orbit and ground test anomalies associated with space power systems. The Department of Defense (DoD) required a method of rapidly obtaining on orbit validation data for new space solar cell technologies, and NRL was tasked to devise an experiment to meet this requirement. Rapid access to space was provided by the MISSE Program which is a NASA Langley Research Center program. MISSE-5 is a completely self-contained experiment system with its own power generation and storage system and communications system. The communications system, referred to as PCSat, transmits

  2. A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells.

    Science.gov (United States)

    Kurtz, Andreas; Seltmann, Stefanie; Bairoch, Amos; Bittner, Marie-Sophie; Bruce, Kevin; Capes-Davis, Amanda; Clarke, Laura; Crook, Jeremy M; Daheron, Laurence; Dewender, Johannes; Faulconbridge, Adam; Fujibuchi, Wataru; Gutteridge, Alexander; Hei, Derek J; Kim, Yong-Ou; Kim, Jung-Hyun; Kokocinski, Anja Kolb-; Lekschas, Fritz; Lomax, Geoffrey P; Loring, Jeanne F; Ludwig, Tenneille; Mah, Nancy; Matsui, Tohru; Müller, Robert; Parkinson, Helen; Sheldon, Michael; Smith, Kelly; Stachelscheid, Harald; Stacey, Glyn; Streeter, Ian; Veiga, Anna; Xu, Ren-He

    2018-01-09

    Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC) lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. We discuss the needs and requirements for such a unique identifier and implement a standard nomenclature for hPSCs, which can be automatically generated and registered by the human pluripotent stem cell registry (hPSCreg). To avoid ambiguities in PSC-line referencing, we strongly urge publishers to demand registration and use of the standard name when publishing research based on hPSC lines. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  3. A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Andreas Kurtz

    2018-01-01

    Full Text Available Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. We discuss the needs and requirements for such a unique identifier and implement a standard nomenclature for hPSCs, which can be automatically generated and registered by the human pluripotent stem cell registry (hPSCreg. To avoid ambiguities in PSC-line referencing, we strongly urge publishers to demand registration and use of the standard name when publishing research based on hPSC lines.

  4. The strategic use of standardized information exchange technology in a university health system.

    Science.gov (United States)

    Cheng, Po-Hsun; Chen, Heng-Shuen; Lai, Feipei; Lai, Jin-Shin

    2010-04-01

    This article illustrates a Web-based health information system that is comprised of specific information exchange standards related to health information for healthcare services in National Taiwan University Health System. Through multidisciplinary teamwork, medical and informatics experts collaborated and studied on system scope definition, standard selection challenges, system implementation barriers, system management outcomes, and further expandability of other systems. After user requirement analysis and prototyping, from 2005 to 2008, an online clinical decision support system with multiple functions of reminding and information push was implemented. It was to replace its original legacy systems and serve among the main hospital and three branches of 180-200 clinics and 7,500-8,000 patient visits per day. To evaluate the effectiveness of this system, user surveys were performed, which revealed that the average score of user satisfaction increased from 2.80 to 3.18 on a 4-point scale. Among the items, especially e-learning for training service, courtesy communications for system requests, and courtesy communications for system operations showed statistically significant improvement. From this study, the authors concluded that standardized information exchange technologies can be used to create a brand new enterprise value and steadily obtain more competitive advantages for a prestige healthcare system.

  5. Commercialization of proton exchange membrane (PEM) fuel cell technology

    International Nuclear Information System (INIS)

    Goel, N.; Pant, A.; Sera, G.

    1995-01-01

    The MCTTC performed a market assessment for PEM Fuel Cells for terrestrial applications for the Center for Space Power (CSP). The purpose of the market assessment was to gauge the market and commercial potential for PEM fuel cell technology. Further, the market assessment was divided into subsections of technical and market overview, competitive environment, political environment, barriers to market entry, and keys to market entry. The market assessment conducted by the MCTTC involved both secondary and primary research. The primary target markets for PEM fuel cells were transportation and utilities in the power range of 10 kW to 100 kW. The fuel cell vehicle market size was estimated under a pessimistic scenario and an optimistic scenario. The estimated size of the fuel cell vehicle market in dollar terms for the year 2005 is $17.3 billion for the pessimistic scenario and $34.7 billion for the optimistic scenario. The fundamental and applied research funded and conducted by the National Aeronautics and Space Administration (NASA) and DOE in the area of fuel cells presents an excellent opportunity to commercialize dual-use technology and enhance U.S. business competitiveness. copyright 1995 American Institute of Physics

  6. Immobilized cell technology in beer brewing: Current experience and results

    Directory of Open Access Journals (Sweden)

    Leskošek-Čukalov Ida J.

    2005-01-01

    Full Text Available Immobilized cell technology (ICT has been attracting continual attention in the brewing industry over the past 30 years. Some of the reasons are: faster fermentation rates and increased volumetric productivity, compared to those of traditional beer production based on freely suspended cells, as well as the possibility of continuous operation. Nowadays, ICT technology is well established in secondary fermentation and alcohol- free and low-alcohol beer production. In main fermentation, the situation is more complex and this process is still under scrutiny on both the lab and pilot levels. The paper outlines the most important ICT processes developed for beer brewing and provides an overview of carrier materials, bioreactor design and examples of their industrial applications, as well as some recent results obtained by our research group. We investigated the possible applications of polyvinyl alcohol in the form of LentiKats®, as a potential porous matrices carrier for beer fermentation. Given are the results of growth studies of immobilized brewer's yeast Saccharomyces uvarum and the kinetic parameters obtained by using alginate microbeads with immobilized yeast cells and suspension of yeast cells as controls. The results indicate that the immobilization procedure in LentiKat® carriers has a negligible effect on cell viability and growth. The apparent specific growth rate of cells released in medium was comparable to that of freely suspended cells, implying preserved cell vitality. A series of batch fermentations performed in shaken flasks and an air-lift bioreactor indicated that the immobilized cells retained high fermentation activity. The full attenuation in green beer was reached after 48 hours in shaken flasks and less than 24 hours of fermentation in gas-lift bioreactors.

  7. An overview to development of fuel cell technology in Iran

    International Nuclear Information System (INIS)

    Amirinejad, M.; Rowshanzamir, S.; Eikani, M.H.

    2005-01-01

    The fuel cell has been known as a modern technology for conversion of chemical energy into electrical energy in the worldwide. Some factors of adaptation to environment targets and high efficiency production of energy are two main reasons that motivated several governments to be active in supporting developments of the fuel cells sector through integrated strategies. The rapid population growth in Iran in recent years is a significant agent of consuming more energy that is satisfied with the fossil resources resulting in environmental problems. The demand for environmental quality and balance in fuel consumption are two main drivers behind the development of fuel cell vehicle in Iran. In order to have sustainable economy and independent on the oil revenue, it is required to make use of oil and natural gas resources in a better manner. Fuel cells are the best candidates to fulfill this requirement. Iran's potential application for this technology in different sectors, design and construction it and fuel system based on natural gas is high. In this paper, current status, potential application, and future research and development of this technology in Iran are investigated

  8. Multijunction Solar Cell Technology for Mars Surface Applications

    Science.gov (United States)

    Stella, Paul M.; Mardesich, Nick; Ewell, Richard C.; Mueller, Robert L.; Endicter, Scott; Aiken, Daniel; Edmondson, Kenneth; Fetze, Chris

    2006-01-01

    Solar cells used for Mars surface applications have been commercial space qualified AM0 optimized devices. Due to the Martian atmosphere, these cells are not optimized for the Mars surface and as a result operate at a reduced efficiency. A multi-year program, MOST (Mars Optimized Solar Cell Technology), managed by JPL and funded by NASA Code S, was initiated in 2004, to develop tools to modify commercial AM0 cells for the Mars surface solar spectrum and to fabricate Mars optimized devices for verification. This effort required defining the surface incident spectrum, developing an appropriate laboratory solar simulator measurement capability, and to develop and test commercial cells modified for the Mars surface spectrum. This paper discusses the program, including results for the initial modified cells. Simulated Mars surface measurements of MER cells and Phoenix Lander cells (2007 launch) are provided to characterize the performance loss for those missions. In addition, the performance of the MER rover solar arrays is updated to reflect their more than two (2) year operation.

  9. Human embryonic stem cell technologies and drug discovery.

    Science.gov (United States)

    Jensen, Janne; Hyllner, Johan; Björquist, Petter

    2009-06-01

    Development of new drugs is costly and takes huge resources into consideration. The big pharmaceutical companies are currently facing increasing developmental costs and a lower success-rate of bringing new compounds to the market. Therefore, it is now of outmost importance that the drug-hunting companies minimize late attritions due to sub-optimal pharmacokinetic properties or unexpected toxicity when entering the clinical programs. To achieve this, a strong need to test new candidate drugs in assays of high human relevance in vitro as early as possible has been identified. The traditionally used cell systems are however remarkably limited in this sense, and new improved technologies are of greatest importance. The human embryonic stem cells (hESC) is one of the most powerful cell types known. They have not only the possibility to divide indefinitely; these cells can also differentiate into all mature cell types of the human body. This makes them potentially very valuable for pharmaceutical development, spanning from use as tools in early target studies, DMPK or safety assessment, as screening models to find new chemical entities modulating adult stem cell fate, or as the direct use in cell therapies. This review illustrates the use of hESC in the drug discovery process, today, as well as in a future perspective. This will specifically be exemplified with the most important cell type for pharmaceutical development-the hepatocyte. We discuss how hESC-derived hepatocyte-like cells could improve this process, and how these cells should be cultured if optimized functionality and usefulness should be achieved. J. Cell. Physiol. 219: 513-519, 2009. (c) 2009 Wiley-Liss, Inc.

  10. The Research on Polymer Microcapsulation for Cell Technology

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhi-bin; LI Min; SONG Hong; FANG Yi; HUA Hui; CHEN Li-guo; ZHOU Wei; WANG Zheng-rong

    2004-01-01

    ).The applications of polymer microcapsules in cell technologyThe "artificial cell" is the biological active microcapsule used in biological and medical fields.The applications of cells (including transgenic cells, the same as artificial cells) technology include several aspects as follows:3.1. Microcapsulation of artificial red cell3.2. Microcapsule of artificial cell of biological enzyme3.3. Microcapsule of artificial cell of magnetic material3.4. Microcapsule of artificial cell of active carbon3.5. Microcapsule of active biological cell

  11. Rapid isolation of bone marrow mesenchymal stromal cells using integrated centrifuge-based technology.

    Science.gov (United States)

    Meppelink, Amanda M; Wang, Xing-Hua; Bradica, Gino; Barron, Kathryn; Hiltz, Kathleen; Liu, Xiang-Hong; Goldman, Scott M; Vacanti, Joseph P; Keating, Armand; Hoganson, David M

    2016-06-01

    The use of bone marrow-derived mesenchymal stromal cells (MSCs) in cell-based therapies is currently being developed for a number of diseases. Thus far, the clinical results have been inconclusive and variable, in part because of the variety of cell isolation procedures and culture conditions used in each study. A new isolation technique that streamlines the method of concentration and demands less time and attention could provide clinical and economic advantages compared with current methodologies. In this study, we evaluated the concentrating capability of an integrated centrifuge-based technology compared with standard Ficoll isolation. MSCs were concentrated from bone marrow aspirate using the new device and the Ficoll method. The isolation capabilities of the device and the growth characteristics, secretome production, and differentiation capacity of the derived cells were determined. The new MSC isolation device concentrated the bone marrow in 90 seconds and resulted in a mononuclear cell yield 10-fold higher and with a twofold increase in cell retention compared with Ficoll. The cells isolated using the device were shown to exhibit similar morphology and functional activity as assessed by growth curves and secretome production compared to the Ficoll-isolated cells. The surface marker and trilineage differentiation profile of the device-isolated cells was consistent with the known profile of MSCs. The faster time to isolation and greater cell yield of the integrated centrifuge-based technology may make this an improved approach for MSC isolation from bone marrow aspirates. Copyright © 2016 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  12. Negotiating sustainable innovation? Hydrogen and fuel cell technologies in Germany

    Directory of Open Access Journals (Sweden)

    Weert Canzler

    2013-06-01

    Full Text Available Recently, the German Federal Government made the consequential decision to change its energy program. This not only as a result of the decision to shut down the existing nuclear power plants within the next few years, but also due to vital challenges like climate change and security of energy supply. The shift in the energy-technology paradigm from fossil fuel technologies to regenerative energies might appear as a merely technical process at first glance. Yet, the road to environmental sustainability is paved with economic and social stumbling blocks. The concept of sustainable development is not a blueprint for technical progress but requires deliberations on questions about innovations and governance: How do we want to live and how do we want to get there? This paper traces the negotiations of sustainable innovation on the example of hydrogen and fuel cell technologies in Germany. The institutional set up in this field is analyzed and the new organizational actors are identified. These actors attempt to inform and persuade others of the benefits of hydrogen and fuel cells in order to establish a common view that is to guide the further development. However, while they succeeded in mobilizing enough actors to launch the largest Public Private Partnership in this sector in the EU, they could not attain the leadership in the public discourse on these technologies. It seems that an attractive guiding vision of a sustainable, post-fossil energy future and a broad acceptance in daily use would have been major prerequisites for such leadership.

  13. Bioelectricity Production from Microalgae-Microbial Fuel Cell Technology (MMFC

    Directory of Open Access Journals (Sweden)

    da Costa Carlito

    2018-01-01

    Full Text Available Microbial fuel cell is an ecological innovative technology producing bioelectricity by utilizing microbes activity. Substituent energy is produced by changing the chemical energy to electrical energy through the catalytic reaction of microorganism. The research aims to find out the potency of bioelectricity produced by microalgae microbial fuel cell technology by utilizing the combination of tapioca wastewater and microalgae cultivation. This research is conducted through the ingredients preparation stage – microalgae culture, wastewater characterization, membrane and graphite activation, and the providing of other supporting equipment. The next stage is the MMFC arrangement, while the last one is bioelectricity measurement. The result of optimal bioelectricity production on the comparison of electrode 2 : 2, the power density is 44,33 mW/m2 on day 6, meanwhile, on that of 1 : 1, 20,18 mW/m2 power density on day 1 is obtained. It shows that bioelectricity can be produced from the combination of tapioca wastewater and microalgae culture through the microalgae-microbial fuel cell (MMFC technology.This research is expected to be a reference for the next research particularly the one that observes the utilizing of microalgae as the part of new and renewable energy sources.

  14. Leading research on cell proliferation regulation technology; Saibo zoshoku seigyo gijutsu no sendo kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    For developing intelligent material, animal test alternative model, bio-cell analysis equipment, self-controlling bio-reactor and medical material, development of functional cells was studied by cell proliferation regulation technology. In fiscal 1996, the expression analysis and separation technology of specific gene for cell proliferation, and the intracellular regulation technology were surveyed from the viewpoint of intracellular regulation. The cell proliferation regulation technology by specific regulating material of cells, extracellular matrix, coculture system and embryonic cell was surveyed from the viewpoint of extracellular regulation. In addition, based on these survey results, new cell culture/analysis technology, new bio-material, artificial organ system, energy saving bio-reactor, environment purification microorganism, and animal test alternative model were surveyed as applications to industrial basic technologies from a long-term viewpoint. The approach to cell proliferation regulation requires preparation of a concrete proliferation regulation technology system of cells, and concrete application targets. 268 refs., 43 figs., 4 tabs.

  15. Technology and Curriculum Standards: How Well Do Internet-Based Learning Games Support Common Core Standards for Mathematics?

    Science.gov (United States)

    Bingham, Teri; Ray, Jan

    2013-01-01

    In an effort to keep up with the new generation of digital learners, educators are integrating multiple forms of technology into their teaching, including online learning game applications. The purpose of this study was to determine the degree to which internet-based learning game applications selected by preservice teachers were aligned with the…

  16. Surveying wearable human assistive technology for life and safety critical applications: standards, challenges and opportunities.

    Science.gov (United States)

    Alam, Muhammad Mahtab; Ben Hamida, Elyes

    2014-05-23

    In this survey a new application paradigm life and safety for critical operations and missions using wearable Wireless Body Area Networks (WBANs) technology is introduced. This paradigm has a vast scope of applications, including disaster management, worker safety in harsh environments such as roadside and building workers, mobile health monitoring, ambient assisted living and many more. It is often the case that during the critical operations and the target conditions, the existing infrastructure is either absent, damaged or overcrowded. In this context, it is envisioned that WBANs will enable the quick deployment of ad-hoc/on-the-fly communication networks to help save many lives and ensuring people's safety. However, to understand the applications more deeply and their specific characteristics and requirements, this survey presents a comprehensive study on the applications scenarios, their context and specific requirements. It explores details of the key enabling standards, existing state-of-the-art research studies, and projects to understand their limitations before realizing aforementioned applications. Application-specific challenges and issues are discussed comprehensively from various perspectives and future research and development directions are highlighted as an inspiration for new innovative solutions. To conclude, this survey opens up a good opportunity for companies and research centers to investigate old but still new problems, in the realm of wearable technologies, which are increasingly evolving and getting more and more attention recently.

  17. Allogeneic cell therapy bioprocess economics and optimization: single-use cell expansion technologies.

    Science.gov (United States)

    Simaria, Ana S; Hassan, Sally; Varadaraju, Hemanthram; Rowley, Jon; Warren, Kim; Vanek, Philip; Farid, Suzanne S

    2014-01-01

    For allogeneic cell therapies to reach their therapeutic potential, challenges related to achieving scalable and robust manufacturing processes will need to be addressed. A particular challenge is producing lot-sizes capable of meeting commercial demands of up to 10(9) cells/dose for large patient numbers due to the current limitations of expansion technologies. This article describes the application of a decisional tool to identify the most cost-effective expansion technologies for different scales of production as well as current gaps in the technology capabilities for allogeneic cell therapy manufacture. The tool integrates bioprocess economics with optimization to assess the economic competitiveness of planar and microcarrier-based cell expansion technologies. Visualization methods were used to identify the production scales where planar technologies will cease to be cost-effective and where microcarrier-based bioreactors become the only option. The tool outputs also predict that for the industry to be sustainable for high demand scenarios, significant increases will likely be needed in the performance capabilities of microcarrier-based systems. These data are presented using a technology S-curve as well as windows of operation to identify the combination of cell productivities and scale of single-use bioreactors required to meet future lot sizes. The modeling insights can be used to identify where future R&D investment should be focused to improve the performance of the most promising technologies so that they become a robust and scalable option that enables the cell therapy industry reach commercially relevant lot sizes. The tool outputs can facilitate decision-making very early on in development and be used to predict, and better manage, the risk of process changes needed as products proceed through the development pathway. © 2013 Wiley Periodicals, Inc.

  18. Physical Principles of Development of the State Standard of Biological Cell Polarizability

    Science.gov (United States)

    Shuvalov, G. V.; Generalov, K. V.; Generalov, V. M.; Kruchinina, M. V.; Koptev, E. S.; Minin, O. V.; Minin, I. V.

    2018-03-01

    A new state standard of biological cell polarizability based on micron-size latex particles has been developed. As a standard material, it is suggested to use polystyrene. Values of the polarizability calculated for erythrocytes and values of the polarizability of micron-size spherical latex particles measured with measuring-computing complexes agree within the limits of satisfactory relative error. The Standard allows one the unit of polarizability measurements [m3] to be assigned to cells and erythrocytes for the needs of medicine.

  19. Standard house with integrated solar cell system. Technical final report; Typehus med integreret solcelleanlaeg. Faglig slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The interest in solar cell technology among Danish house owners is increasing, but there are many considerations to be made before the house owner choose to install solar cells on the house. Major barriers are the solar cell systems' price and appearance. This interdisciplinary development project will show that both aesthetic and economic advantages can be derived from integrating solar cells already when the first sketches of the house are being made. In order to promote utilization of solar cells in Denmark the solutions must be attractive, both economically and aesthetically. Therefore the solar cell solutions in this project are developed in preparation for marketing both as an aesthetic expression and a high-technological, green and prestigious element. (BA)

  20. A reliable parameter to standardize the scoring of stem cell spheres.

    Directory of Open Access Journals (Sweden)

    Xiaochen Zhou

    Full Text Available Sphere formation assay is widely used in selection and enrichment of normal stem cells or cancer stem cells (CSCs, also known as tumor initiating cells (TICs, based on their ability to grow in serum-free suspension culture for clonal proliferation. However, there is no standardized parameter to accurately score the spheres, which should be reflected by both the number and size of the spheres. Here we define a novel parameter, designated as Standardized Sphere Score (SSS, which is expressed by the total volume of selected spheres divided by the number of cells initially plated. SSS was validated in quantification of both tumor spheres from cancer cell lines and embryonic bodies (EB from mouse embryonic stem cells with high sensitivity and reproducibility.

  1. Controlled alpha-sexithiophene nanostructure formation in standard and inverted configuration organic solar cells

    DEFF Research Database (Denmark)

    Radziwon, Michal Jędrzej; Goszczak, Arkadiusz Jaroslaw; Fernandes Cauduro, André Luis

    -type domains in the active organic layer. The molecular packing in these is of same importance, as it strongly affects the carrier transport in the cells. In this work, we present the study of alpha-sexithiophene (α 6T) temperature dependent growth for standard, on gold anodes, and inverted, on electron...... accepting C60 layers, solar cell configurations. Furthermore, a comparative study of the correlation between the α-6T morphology and device performance parameters for standard and inverted solar cell configurations is presented. The morphology of the α 6T layer is controlled by means of the substrate...

  2. Stem Cell Technology for (Epi)genetic Brain Disorders.

    Science.gov (United States)

    Riemens, Renzo J M; Soares, Edilene S; Esteller, Manel; Delgado-Morales, Raul

    2017-01-01

    Despite the enormous efforts of the scientific community over the years, effective therapeutics for many (epi)genetic brain disorders remain unidentified. The common and persistent failures to translate preclinical findings into clinical success are partially attributed to the limited efficiency of current disease models. Although animal and cellular models have substantially improved our knowledge of the pathological processes involved in these disorders, human brain research has generally been hampered by a lack of satisfactory humanized model systems. This, together with our incomplete knowledge of the multifactorial causes in the majority of these disorders, as well as a thorough understanding of associated (epi)genetic alterations, has been impeding progress in gaining more mechanistic insights from translational studies. Over the last years, however, stem cell technology has been offering an alternative approach to study and treat human brain disorders. Owing to this technology, we are now able to obtain a theoretically inexhaustible source of human neural cells and precursors in vitro that offer a platform for disease modeling and the establishment of therapeutic interventions. In addition to the potential to increase our general understanding of how (epi)genetic alterations contribute to the pathology of brain disorders, stem cells and derivatives allow for high-throughput drugs and toxicity testing, and provide a cell source for transplant therapies in regenerative medicine. In the current chapter, we will demonstrate the validity of human stem cell-based models and address the utility of other stem cell-based applications for several human brain disorders with multifactorial and (epi)genetic bases, including Parkinson's disease (PD), Alzheimer's disease (AD), fragile X syndrome (FXS), Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Rett syndrome (RTT).

  3. [Three dimensional bioprinting technology of human dental pulp cells mixtures].

    Science.gov (United States)

    Xue, Shi-hua; Lv, Pei-jun; Wang, Yong; Zhao, Yu; Zhang, Ting

    2013-02-18

    To explore the three dimensional(3D)bioprinting technology, using human dental pulp cells (hDPCs) mixture as bioink and to lay initial foundations for the application of the 3D bioprinting technology in tooth regeneration. Imageware 11.0 computer software was used to aid the design of the 3D biological printing blueprint. Sodium alginate-gelatin hydrosol was prepared and mixed with in vitro isolated hDPCs. The mixture contained 20 g/L sodium alginate and 80 g/L gelatin with cell density of 1×10(6)/mL. The bioprinting of hDPCs mixture was carried out according to certain parameters; the 3D constructs obtained by printing were examined; the viability of hDPCs after printing by staining the constructs with calcein-AM and propidium iodide dye and scanning of laser scanning confocal microscope was evaluated. The in vitro constructs obtained by the bioprinting were cultured, and the proliferation of hDPCs in the constructs detected. By using Imageware 11.0 software, the 3D constructs with the grid structure composed of the accumulation of staggered cylindrical microfilament layers were obtained. According to certain parameters, the hDPCs-sodium alginate-gelatin blends were printed by the 3D bioprinting technology. The self-defined shape and dimension of 3D constructs with the cell survival rate of 87%± 2% were constructed. The hDPCs could proliferate in 3D constructs after printing. In this study, the 3D bioprinting of hDPCs mixtures was realized, thus laying initial foundations for the application of the 3D bioprinting technology in tooth regeneration.

  4. Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

    Science.gov (United States)

    Che, James; Yu, Victor; Dhar, Manjima; Renier, Corinne; Matsumoto, Melissa; Heirich, Kyra; Garon, Edward B.; Goldman, Jonathan; Rao, Jianyu; Sledge, George W.; Pegram, Mark D.; Sheth, Shruti; Jeffrey, Stefanie S.; Kulkarni, Rajan P.; Sollier, Elodie; Di Carlo, Dino

    2016-01-01

    Circulating tumor cells (CTCs) are emerging as rare but clinically significant non-invasive cellular biomarkers for cancer patient prognosis, treatment selection, and treatment monitoring. Current CTC isolation approaches, such as immunoaffinity, filtration, or size-based techniques, are often limited by throughput, purity, large output volumes, or inability to obtain viable cells for downstream analysis. For all technologies, traditional immunofluorescent staining alone has been employed to distinguish and confirm the presence of isolated CTCs among contaminating blood cells, although cells isolated by size may express vastly different phenotypes. Consequently, CTC definitions have been non-trivial, researcher-dependent, and evolving. Here we describe a complete set of objective criteria, leveraging well-established cytomorphological features of malignancy, by which we identify large CTCs. We apply the criteria to CTCs enriched from stage IV lung and breast cancer patient blood samples using the High Throughput Vortex Chip (Vortex HT), an improved microfluidic technology for the label-free, size-based enrichment and concentration of rare cells. We achieve improved capture efficiency (up to 83%), high speed of processing (8 mL/min of 10x diluted blood, or 800 μL/min of whole blood), and high purity (avg. background of 28.8±23.6 white blood cells per mL of whole blood). We show markedly improved performance of CTC capture (84% positive test rate) in comparison to previous Vortex designs and the current FDA-approved gold standard CellSearch assay. The results demonstrate the ability to quickly collect viable and pure populations of abnormal large circulating cells unbiased by molecular characteristics, which helps uncover further heterogeneity in these cells. PMID:26863573

  5. EarthServer: a Summary of Achievements in Technology, Services, and Standards

    Science.gov (United States)

    Baumann, Peter

    2015-04-01

    based on OGC and W3C standards, in particular the Web Coverage Processing Service (WCPS) which defines a high-level coverage query language. Reviewers have attested EarthServer that "With no doubt the project has been shaping the Big Earth Data landscape through the standardization activities within OGC, ISO and beyond". We present the project approach, its outcomes and impact on standardization and Big Data technology, and vistas for the future.

  6. Leveraging Open Standards and Technologies to Enhance Community Access to Earth Science Lidar Data

    Science.gov (United States)

    Crosby, C. J.; Nandigam, V.; Krishnan, S.; Cowart, C.; Baru, C.; Arrowsmith, R.

    2011-12-01

    Lidar (Light Detection and Ranging) data, collected from space, airborne and terrestrial platforms, have emerged as an invaluable tool for a variety of Earth science applications ranging from ice sheet monitoring to modeling of earth surface processes. However, lidar present a unique suite of challenges from the perspective of building cyberinfrastructure systems that enable the scientific community to access these valuable research datasets. Lidar data are typically characterized by millions to billions of individual measurements of x,y,z position plus attributes; these "raw" data are also often accompanied by derived raster products and are frequently terabytes in size. As a relatively new and rapidly evolving data collection technology, relevant open data standards and software projects are immature compared to those for other remote sensing platforms. The NSF-funded OpenTopography Facility project has developed an online lidar data access and processing system that co-locates data with on-demand processing tools to enable users to access both raw point cloud data as well as custom derived products and visualizations. OpenTopography is built on a Service Oriented Architecture (SOA) in which applications and data resources are deployed as standards compliant (XML and SOAP) Web services with the open source Opal Toolkit. To develop the underlying applications for data access, filtering and conversion, and various processing tasks, OpenTopography has heavily leveraged existing open source software efforts for both lidar and raster data. Operating on the de facto LAS binary point cloud format (maintained by ASPRS), open source libLAS and LASlib libraries provide OpenTopography data ingestion, query and translation capabilities. Similarly, raster data manipulation is performed through a suite of services built on the Geospatial Data Abstraction Library (GDAL). OpenTopography has also developed our own algorithm for high-performance gridding of lidar point cloud data

  7. Smooth muscle-like tissue constructs with circumferentially oriented cells formed by the cell fiber technology.

    Science.gov (United States)

    Hsiao, Amy Y; Okitsu, Teru; Onoe, Hiroaki; Kiyosawa, Mahiro; Teramae, Hiroki; Iwanaga, Shintaroh; Kazama, Tomohiko; Matsumoto, Taro; Takeuchi, Shoji

    2015-01-01

    The proper functioning of many organs and tissues containing smooth muscles greatly depends on the intricate organization of the smooth muscle cells oriented in appropriate directions. Consequently controlling the cellular orientation in three-dimensional (3D) cellular constructs is an important issue in engineering tissues of smooth muscles. However, the ability to precisely control the cellular orientation at the microscale cannot be achieved by various commonly used 3D tissue engineering building blocks such as spheroids. This paper presents the formation of coiled spring-shaped 3D cellular constructs containing circumferentially oriented smooth muscle-like cells differentiated from dedifferentiated fat (DFAT) cells. By using the cell fiber technology, DFAT cells suspended in a mixture of extracellular proteins possessing an optimized stiffness were encapsulated in the core region of alginate shell microfibers and uniformly aligned to the longitudinal direction. Upon differentiation induction to the smooth muscle lineage, DFAT cell fibers self-assembled to coiled spring structures where the cells became circumferentially oriented. By changing the initial core-shell microfiber diameter, we demonstrated that the spring pitch and diameter could be controlled. 21 days after differentiation induction, the cell fibers contained high percentages of ASMA-positive and calponin-positive cells. Our technology to create these smooth muscle-like spring constructs enabled precise control of cellular alignment and orientation in 3D. These constructs can further serve as tissue engineering building blocks for larger organs and cellular implants used in clinical treatments.

  8. Pathways to Commercial Success: Technologies and Innovations Enabled by the U.S. Department of Energy Fuel Cell Technologies Office

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-10-11

    This report published in October 2017 updates the results of an effort to identify and document the commercial and emerging (projected to be commercialized within the next 3 to 5 years) hydrogen and fuel cell technologies and products that resulted from U.S. Department of Energy support through the Fuel Cell Technologies Office in the Office of Energy Efficiency and Renewable Energy.

  9. COMPENDIUM: SURVEYS EVALUATING KNOWLEDGE AND OPINIONS CONCERNING HYDROGEN AND FUEL CELL TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    Truett, Lorena Faith [ORNL; Cooper, Christy [U.S. Department of Energy; Schmoyer, Richard L [ORNL

    2008-10-01

    This compendium updates a 2003 literature review of surveys of knowledge and opinions of hydrogen and fuel cell technologies. Its purpose is to ensure that results of comparable surveys are considered in surveys conducted by the U.S. Department of Energy (DOE). Over twice as many studies related to the DOE survey have been published since 2003 than prior to that date. The fact that there have been significantly more studies implies that there have been further demonstration projects and/or increased interest in hydrogen and fuel cell technologies. The primary findings of these 15 new surveys, all of which were conducted in Europe (E) or North America (NA), to the DOE surveys are as follows: 1.Respondents who are more educated are more accepting of hydrogen technologies (NA). 2.Respondents who are more knowledgeable about hydrogen and/or fuel cells are more accepting of hydrogen technologies (E, NA). 3.When asked about issues of trust, respondents generally expressed distrust of the government or political parties but trusted scientists and environmental protection organizations (E). 4.Technical knowledge about hydrogen and fuel cell technologies is low (E, NA). 5.Respondents may express opinions about a technology even when they are lacking in knowledge of that technology (E). 6.Women and men have different priorities when deciding on an automobile purchase (E). 7.Public acceptance to hydrogen is vulnerable to perceptions of decreased safety (E, NA). 8.Public acceptance to hydrogen is vulnerable to perceptions of increased cost (E, NA). The DOE surveys are similar to surveys that examine technical knowledge of hydrogen and fuel cell technologies, although the technical questions are certainly different. The DOE surveys are also similar to the opinion surveys in that they address many of the same issues, such as safety, sources of energy information, or trust. There are many differences between the surveys reviewed in this compendium and the DOE surveys. The

  10. Nuclear technology transfer via standards: the OMB Circular A-119 in action

    International Nuclear Information System (INIS)

    Zapp, F.C.

    1986-01-01

    The Performance Assurance Project Office (PAPO) has 23 nuclear energy (NE) standards in some phase of conversion to the national consensus standards, and identified three new NE standards for possible conversion. The author describes the methods of developing a consensus for standards through the use of working groups and ballots and the process of adopting a standard. Voluntary NE standards categories cover operation, instrumentation and controls, equipment, programs and procedures, materials, electrical, and structures and building. 4 references, 2 tables

  11. Technology of solar cells of CuInSe-2

    International Nuclear Information System (INIS)

    Gordillo, Gerardo; Rodriguez, Jairo A

    1993-01-01

    The energetic problem in the World is at the present time one of the topics of more interest; for that reason the study of the transformation of the solar energy in electric power, using photovoltaic devices, it is a field of great priority in the investigation. The direct conversion of the solar energy in electric power, using solar cells, it represents an interesting alternative to replace a fraction of the energy deficit that will present as consequence of the limited reservations of hydrocarbons. At the present time they are had in experimentation plants lots of megawatts based on cells of silicon mono-crystalline. The solar cell technologically more developed it is that of silicon mono-crystalline; however their production cost is too high and difficultly it could compete economically with the traditional forms of generating energy; for this reason they are becoming big efforts and economic investments to develop solar cells of high efficiency and stability with base in thin movies whose production costs are much lower compared with those of cells of crystalline silicon

  12. Surface etching technologies for monocrystalline silicon wafer solar cells

    Science.gov (United States)

    Tang, Muzhi

    With more than 200 GW of accumulated installations in 2015, photovoltaics (PV) has become an important green energy harvesting method. The PV market is dominated by solar cells made from crystalline silicon wafers. The engineering of the wafer surfaces is critical to the solar cell cost reduction and performance enhancement. Therefore, this thesis focuses on the development of surface etching technologies for monocrystalline silicon wafer solar cells. It aims to develop a more efficient alkaline texturing method and more effective surface cleaning processes. Firstly, a rapid, isopropanol alcohol free texturing method is successfully demonstrated to shorten the process time and reduce the consumption of chemicals. This method utilizes the special chemical properties of triethylamine, which can form Si-N bonds with wafer surface atoms. Secondly, a room-temperature anisotropic emitter etch-back process is developed to improve the n+ emitter passivation. Using this method, 19.0% efficient screen-printed aluminium back surface field solar cells are developed that show an efficiency gain of 0.15% (absolute) compared with conventionally made solar cells. Finally, state-of-the-art silicon surface passivation results are achieved using hydrogen plasma etching as a dry alternative to the classical hydrofluoric acid wet-chemical process. The effective native oxide removal and the hydrogenation of the silicon surface are shown to be the reasons for the excellent level of surface passivation achieved with this novel method.

  13. Neurorestorative clinical application standards for the culture and quality control of olfactory ensheathing cells

    Directory of Open Access Journals (Sweden)

    Xiao J

    2017-09-01

    Full Text Available Juan Xiao,1,2 Lin Chen,3 Gengsheng Mao,1 Wenyong Gao,1,2 Ming Lu,4 Xijing He,5 Hongyun Huang1,2 On behalf of the Neurorestoratology Professional Committee of Chinese Medical Doctors Association (Chinese Association of Neurorestoratology 1Institute of Neurorestoratology, The General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China; 2Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Beijing, People’s Republic of China; 3Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, People’s Republic of China; 4Department of Neurosurgery, 163 Hospital of PLA (Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, People’s Republic of China; 5Department of Orthopedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xian, Shanxi Provine, People’s Republic of China Abstract: Olfactory ensheathing cells (OECs are a novel type of glial cell that can perform and promote many neurorestorative processes in vivo after transplant. To date, dozens of preclinical and clinical studies have confirmed that OECs have unique restoring effects in animal models and human subjects with neurological degeneration or damage, such as spinal cord injury, stroke, cerebral palsy, traumatic brain injury, and motor neuron disease (amyotrophic lateral sclerosis. To ensure the safety and effectiveness of clinical applications utilizing this type of cell, it is important to standardize cell-culture and quality-control processes. Based on a comprehensive review of published clinical studies, as well as existing methods of OEC culture and quality control currently utilized by hospitals and biomedical enterprises, the Chinese Association of Neurorestoratology has developed a set of standards for the culture and quality control of olfactory ensheathing cells for use in clinical applications. These guidelines include standardized training and management procedures for

  14. Dry technologies for the production of crystalline silicon solar cells; Trockentechnologien zur Herstellung von kristallinen Siliziumsolarzellen

    Energy Technology Data Exchange (ETDEWEB)

    Rentsch, J.

    2005-04-15

    Within this work, dynamic plasma etching technologies for the industrial production of crystalline silicon solar cells has been investigated. The research activity can be separated into three major steps: the characterisation of the etching behaviour of a newly developed dynamic plasma etching system, the development and analysis of dry etching processes for solar cell production and the determination of the ecological and economical impacts of such a new technology compared to standard up to date technologies. The characterisation of the etching behaviour has been carried out for two different etching sources, a low frequency (110 kHz) and a microwave (2.45 GHz) plasma source. The parameter of interest was the delivered ion energy of each source mainly determining the reachable etch rate. The etch rate turned out to be the main most critical parameter concerning the reachable wafer throughput per hour. Other points of interest in characterisation of the etching system were the material of the transport carriers, the silicon load as well as the process temperatures. The development of different dry etching processes targets the design of a complete dry production process for crystalline silicon solar cells. Therefore etching processes for saw damage removal, texturing, edge isolation as well as etching of dielectric layers have been developed and optimised. The major benefits of a complete dry production process would be the reduction of handling steps in between process steps and therefore offers a large cost reduction potential. For multicrystalline silicon solar cells a cost reduction potential of 5 % compared to a standard wet chemical based reference process could be realized only including the dry etching of a phosphorus silicate glass layer after diffusion. Further reduction potential offers the implementation of a dry texturing process due to a significant efficiency increase. (orig.)

  15. Endovascular treatment outcomes using the Stroke Triage Education, Procedure Standardization, and Technology (STEPS-T) program.

    Science.gov (United States)

    Hassan, Ameer E; Sanchez, Christina; Johnson, Angela N

    2018-02-01

    Background "Door to treatment" time affects outcomes of acute ischemic stroke (AIS) patients undergoing endovascular treatment (EVT). However, the correlation between staff education and accessible technology with stroke outcomes has not been demonstrated. Objective The objective of this paper is to demonstrate the five-year impact of the Stroke Triage Education, Procedure Standardization, and Technology (STEPS-T) program on time-to-treat and clinical outcomes. Methods The study analyzed a prospectively maintained database of AIS patients who benefited from EVT through implementation of STEPS-T. Demographics, clinical characteristics, and modified Rankin Score at three months were analyzed. Thrombolysis in Cerebral Infarction (TICI) scale was used to grade pre- and post-procedure angiographic recanalization. Using electronic hemodynamic recording, stepwise workflow times were collected for door time (T D ), entering angiography suite (T A ), groin puncture (T G ), first DSA (T DSA ), microcatheter placement (T M ), and final recanalization (T R ). Median intervention time (T A to T R ) and recanalization time (T G to T R ) were compared through Year 1 to Year 5. Results A total of 230 individuals (age 74 ± 12, between 30 to 95) were enrolled. Median intervention and recanalization times were significantly reduced, from 121 minutes to 52 minutes and from 83 minutes to 36 minutes respectively from Year 1 to Year 5, ( p < 0.001). Across the study period, annual recruitment went up from 12 to 66 patients, and modified Rankin Score between 0 and 2 increased from 36% to 59% ( p = 0.024). Conclusions STEPS-T improved time-to-treat in patients undergoing mechanical thrombectomy for AIS. During the observation period, clinical outcomes significantly improved.

  16. A new approach to standardize multicenter studies: mobile lab technology for the German Environmental Specimen Bank.

    Directory of Open Access Journals (Sweden)

    Dominik Lermen

    Full Text Available Technical progress has simplified tasks in lab diagnosis and improved quality of test results. Errors occurring during the pre-analytical phase have more negative impact on the quality of test results than errors encountered during the total analytical process. Different infrastructures of sampling sites can highly influence the quality of samples and therewith of analytical results. Annually the German Environmental Specimen Bank (ESB collects, characterizes, and stores blood, plasma, and urine samples of 120-150 volunteers each on four different sampling sites in Germany. Overarching goal is to investigate the exposure to environmental pollutants of non-occupational exposed young adults combining human biomonitoring with questionnaire data. We investigated the requirements of the study and the possibility to realize a highly standardized sampling procedure on a mobile platform in order to increase the required quality of the pre-analytical phase. The results lead to the development of a mobile epidemiologic laboratory (epiLab in the project "Labor der Zukunft" (future's lab technology. This laboratory includes a 14.7 m(2 reception area to record medical history and exposure-relevant behavior, a 21.1 m(2 examination room to record dental fillings and for blood withdrawal, a 15.5 m(2 biological safety level 2 laboratory to process and analyze samples on site including a 2.8 m(2 personnel lock and a 3.6 m2 cryofacility to immediately freeze samples. Frozen samples can be transferred to their final destination within the vehicle without breaking the cold chain. To our knowledge, we herewith describe for the first time the implementation of a biological safety laboratory (BSL 2 lab and an epidemiologic unit on a single mobile platform. Since 2013 we have been collecting up to 15.000 individual human samples annually under highly standardized conditions using the mobile laboratory. Characterized and free of alterations they are kept ready for

  17. A new approach to standardize multicenter studies: mobile lab technology for the German Environmental Specimen Bank.

    Science.gov (United States)

    Lermen, Dominik; Schmitt, Daniel; Bartel-Steinbach, Martina; Schröter-Kermani, Christa; Kolossa-Gehring, Marike; von Briesen, Hagen; Zimmermann, Heiko

    2014-01-01

    Technical progress has simplified tasks in lab diagnosis and improved quality of test results. Errors occurring during the pre-analytical phase have more negative impact on the quality of test results than errors encountered during the total analytical process. Different infrastructures of sampling sites can highly influence the quality of samples and therewith of analytical results. Annually the German Environmental Specimen Bank (ESB) collects, characterizes, and stores blood, plasma, and urine samples of 120-150 volunteers each on four different sampling sites in Germany. Overarching goal is to investigate the exposure to environmental pollutants of non-occupational exposed young adults combining human biomonitoring with questionnaire data. We investigated the requirements of the study and the possibility to realize a highly standardized sampling procedure on a mobile platform in order to increase the required quality of the pre-analytical phase. The results lead to the development of a mobile epidemiologic laboratory (epiLab) in the project "Labor der Zukunft" (future's lab technology). This laboratory includes a 14.7 m(2) reception area to record medical history and exposure-relevant behavior, a 21.1 m(2) examination room to record dental fillings and for blood withdrawal, a 15.5 m(2) biological safety level 2 laboratory to process and analyze samples on site including a 2.8 m(2) personnel lock and a 3.6 m2 cryofacility to immediately freeze samples. Frozen samples can be transferred to their final destination within the vehicle without breaking the cold chain. To our knowledge, we herewith describe for the first time the implementation of a biological safety laboratory (BSL) 2 lab and an epidemiologic unit on a single mobile platform. Since 2013 we have been collecting up to 15.000 individual human samples annually under highly standardized conditions using the mobile laboratory. Characterized and free of alterations they are kept ready for retrospective

  18. Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes.

    Science.gov (United States)

    Kondrashina, Alina V; Papkovsky, Dmitri B; Dmitriev, Ruslan I

    2013-09-07

    Measurement of cell oxygenation and oxygen consumption is useful for studies of cell bioenergetics, metabolism, mitochondrial function, drug toxicity and common pathophysiological conditions. Here we present a new platform for such applications which uses commercial multichannel biochips (μ-slides, Ibidi) and phosphorescent O2 sensitive probes. This platform was evaluated with both extracellular and intracellular O2 probes, several different cell types and treatments including mitochondrial uncoupling and inhibition, depletion of extracellular Ca(2+) and inhibition of V-ATPase and histone deacetylases. The results show that compared to the standard microwell plates currently used, the μ-slide platform provides facile O2 measurements with both suspension and adherent cells, higher sensitivity and reproducibility, and faster measurement time. It also allows re-perfusion and multiple treatments of cells and multi-parametric analyses in conjunction with other probes. Optical measurements are conducted on standard fluorescence readers and microscopes.

  19. Status and prospects of fuel cell technology in Europe

    International Nuclear Information System (INIS)

    Van Dijkum

    1998-01-01

    Fuel Cells attract a lot of press attention today and an some example of a recent press heading is: ''Orders for Onsi's fuel cells hit $111 million''. The principle of fuel cell technology is explained and examples of realized applications given. In short: fuel cells can be used everywhere where power (and heat) is needed. Regarding the status of fuel cells, Europe is way behind Japan and the US. The 15 PAFC-200 kWe units in operation in Europe (worldwide > 90 units) produced 46,796 MWhe during 296,704 cumulative operating hours with an availability % over 70.00. The world record on continuous operation is held by Japan with 9,478 hours reached at 14th September 1996 and two PAFC-units passed their 40,000 hours of cumulative operation (US and Japan). In Japan, market enabling support is continued with subsidies of one third of the costs for 7 PAFC-units. In the Netherlands, Energy Distribution Companies test their tubular 100 kWe SOFC-unit. During 1,335 hours of continuous operation, the unit produced 165 MWhe in total at 3rd March. EnergieNed, CLC/Ansaldo and Gastec evaluated changes for co-generation and small power production with packaged fuel cell power plants in EU and EFTA countries. In general the authors concluded that implementation of fuel cell power plants in all EU and EFTA countries will be probably possible with today' s technical regulations. On might wonder: What has fuel cell technology to offer in one of the most efficient and low-priced gas economies in Europe, the Netherlands. An example of efficient energy use are greenhouses with artificial lighting and CO 2 -fertilization and energy (heat) storage device. Applying relatively favorable depreciation periods and (utility) interest rate, a PAFC 200 kWe generates just a positive return (IRR = 1.7 % after taxes and subsidies) when part of a gas-engine capacity is replaced

  20. Reverse engineering human neurodegenerative disease using pluripotent stem cell technology.

    Science.gov (United States)

    Liu, Ying; Deng, Wenbin

    2016-05-01

    With the technology of reprogramming somatic cells by introducing defined transcription factors that enables the generation of "induced pluripotent stem cells (iPSCs)" with pluripotency comparable to that of embryonic stem cells (ESCs), it has become possible to use this technology to produce various cells and tissues that have been difficult to obtain from living bodies. This advancement is bringing forth rapid progress in iPSC-based disease modeling, drug screening, and regenerative medicine. More and more studies have demonstrated that phenotypes of adult-onset neurodegenerative disorders could be rather faithfully recapitulated in iPSC-derived neural cell cultures. Moreover, despite the adult-onset nature of the diseases, pathogenic phenotypes and cellular abnormalities often exist in early developmental stages, providing new "windows of opportunity" for understanding mechanisms underlying neurodegenerative disorders and for discovering new medicines. The cell reprogramming technology enables a reverse engineering approach for modeling the cellular degenerative phenotypes of a wide range of human disorders. An excellent example is the study of the human neurodegenerative disease amyotrophic lateral sclerosis (ALS) using iPSCs. ALS is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs), culminating in muscle wasting and death from respiratory failure. The iPSC approach provides innovative cell culture platforms to serve as ALS patient-derived model systems. Researchers have converted iPSCs derived from ALS patients into MNs and various types of glial cells, all of which are involved in ALS, to study the disease. The iPSC technology could be used to determine the role of specific genetic factors to track down what's wrong in the neurodegenerative disease process in the "disease-in-a-dish" model. Meanwhile, parallel experiments of targeting the same specific genes in human ESCs could also be performed to control

  1. Single-cell technologies in molecular marine studies

    KAUST Repository

    Kodzius, Rimantas

    2015-01-24

    Middle Eastern countries are experiencing a renaissance, with heavy investment in both in infrastructure and science. King Abdullah University of Science and Technology (KAUST) is a new and modern university in Saudi Arabia. At the Computational Bioscience Research Center (CBRC) we are working on exploring the Red Sea and beyond, collaborating with Japanese and other research centers. We are using the environment to collect and analyze the microorganisms present. The platform being established at CBRC allows to process samples in a pipeline. The pipeline components consist of sample collection, processing and sequencing, following the in silico analysis, determining the gene functions, identifying the organisms. The genomes of microorganisms of interest are targeted modified by genome editing technology such as CRISPR and desired properties are selected by single cell instrumentation. The final output is to identify valuable microorganisms with production of bio-energy, nutrients, the food and fine chemicals.

  2. Science and Math Lesson Plans to Meet the Ohio Revised Science Standards and the Next Generation of Standards for Today; Technology (Excel

    Directory of Open Access Journals (Sweden)

    Suzanne Lunsford

    2015-02-01

    Full Text Available Pre-service teachers (K-12 developed and taught lesson plans that met the state and national science and technology standards by integrating Excel and PowerPoint into their lesson. A sample of 74 pre-service teachers in our science education program were required to integrate technology (Excel as they developed science and math lesson plans with graphing as a requirement. These students took pre-test and post-test (n=74 to determine their understanding of Excel in relation to the need of current technology for todays' science classroom. The test results showed that students obtained content gains in Excel graphing in all the inquiry-based lab experiments. They also gained experience in developing math skills, inquiry-based science lesson plans, and communication and presentation skills.

  3. Hydrogen and fuel cells emerging technologies and applications

    CERN Document Server

    Sorensen (Sorensen), Bent

    2011-01-01

    A hydrogen economy, in which this one gas provides the source of all energy needs, is often touted as the long-term solution to the environmental and security problems associated with fossil fuels. However, before hydrogen can be used as fuel on a global scale we must establish cost effective means of producing, storing, and distributing the gas, develop cost efficient technologies for converting hydrogen to electricity (e.g. fuel cells), and creating the infrastructure to support all this. Sorensen is the only text available that provides up to date coverage of all these issues at a level

  4. Progress in N-type Si Solar Cell and Module Technology for High Efficiency and Low Cost

    Energy Technology Data Exchange (ETDEWEB)

    Song, Dengyuan; Xiong, Jingfeng; Hu, Zhiyan; Li, Gaofei; Wang, Hongfang; An, Haijiao; Yu, Bo; Grenko, Brian; Borden, Kevin; Sauer, Kenneth; Cui, Jianhua; Wang, Haitao [Yingli Green Energy Holding Co., LTD, 071051 Boading (China); Roessler, T. [Yingli Green Energy Europe GmbH, Heimeranstr. 37, 80339 Munich (Germany); Bultman, J. [ECN Solar Energy, P.O. Box 1, NL-1755 ZG Petten (Netherlands); Vlooswijk, A.H.G.; Venema, P.R. [Tempress Systems BV, Radeweg 31, 8171 Vaassen (Netherlands)

    2012-06-15

    A novel high efficiency solar cell and module technology, named PANDA, using crystalline n-type CZ Si wafers has moved into large-scale production at Yingli. The first commercial sales of the PANDA modules commenced in mid 2010. Up to 600MW of mass production capacity from crystal-Si growth, wafer slicing, cell processing and module assembly have been implemented by the end of 2011. The PANDA technology was developed specifically for high efficiency and low cost. In contrast to the existing n-type Si solar cell manufacturing methods in mass production, this new technology is largely compatible with a traditional p-type Si solar cell production line by conventional diffusion, SiNx coating and screen-printing technology. With optimizing all technologies, Yingli's PANDA solar cells on semi-square 6-inch n-type CZ wafers (cell size 239cm{sup 2}) have been improved to currently have an average efficiency on commercial production lines exceeding 19.0% and up to 20.0% in pilot production. The PANDA modules have been produced and were certified according to UL1703, IEC 61215 and IEC 61730 standards. Nearly two years of full production on scale-up lines show that the PANDA modules have a high efficiency and power density, superior high temperature performance, near zero initial light induced degradation, and excellent efficiency at low irradiance.

  5. TDT in Argentine and Chile: dynamics of power in the process of adoption of the technological standard ISDB-TB

    Directory of Open Access Journals (Sweden)

    Carla RODRÍGUEZ MIRANDA

    2012-02-01

    Full Text Available The article analyses the media policymaking process about the adoption of the technological standard for the digital terrestrial television in Argentine and Chile. The explorative and descriptive study inquires about the tensions, articulations and dynamics of the national and supranational parties (State, broadcasters, lobbies of technical standards and civil society that played in the politic process from the late 90s when the issue of digital television inserted into public agenda until August/September on 2009 when both countries adopted the Japanese- Brazilian technology system.

  6. European hydrogen and fuel cell technology platform. Strategic overview

    Energy Technology Data Exchange (ETDEWEB)

    Alleau, Th

    2005-07-01

    In January 2004, following the recommendation of the High Level Group, the European Commission set up the European Hydrogen and Fuel Cell Technology Platform (HFP) a partnership of over 300 stakeholders. Its brief? To prepare and direct an effective strategy for bringing hydrogen and fuel cells to market in order to exploit their outstanding environmental and economic potential. An Advisory Council of 35 representatives from a broad range of industry, EC, public authority, academic and NGO stakeholders was set up to guide the activity, together with a number of subsidiary bodies. Two steering panels were then charged with defining a Strategic Research Agenda (SRA) and Deployment Strategy (DS) respectively in order to drive the transition forward. This report gives a work in progress strategic overview, with further details provided in the Executive Summaries of the Strategic Research Agenda and Deployment Strategy foundation documents. (authors)

  7. European hydrogen and fuel cell technology platform. Strategic overview

    International Nuclear Information System (INIS)

    Alleau, Th.

    2005-01-01

    In January 2004, following the recommendation of the High Level Group, the European Commission set up the European Hydrogen and Fuel Cell Technology Platform (HFP) a partnership of over 300 stakeholders. Its brief? To prepare and direct an effective strategy for bringing hydrogen and fuel cells to market in order to exploit their outstanding environmental and economic potential. An Advisory Council of 35 representatives from a broad range of industry, EC, public authority, academic and NGO stakeholders was set up to guide the activity, together with a number of subsidiary bodies. Two steering panels were then charged with defining a Strategic Research Agenda (SRA) and Deployment Strategy (DS) respectively in order to drive the transition forward. This report gives a work in progress strategic overview, with further details provided in the Executive Summaries of the Strategic Research Agenda and Deployment Strategy foundation documents. (authors)

  8. Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise.

    Science.gov (United States)

    Duelen, Robin; Sampaolesi, Maurilio

    2017-02-01

    Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment, survival and differentiation of the injected adult stem cells. The crucial challenge is identification and selection of the most suitable stem cell type for cardiac regenerative medicine. Human pluripotent stem cells (PSCs) have emerged as attractive cell source to obtain cardiomyocytes (CMs), with potential applications, including drug discovery and toxicity screening, disease modelling and innovative cell therapies. Lessons from embryology offered important insights into the development of stem cell-derived CMs. However, the generation of a CM population, uniform in cardiac subtype, adult maturation and functional properties, is highly recommended. Moreover, hurdles regarding tumorigenesis, graft cell death, immune rejection and arrhythmogenesis need to be overcome in clinical practice. Here we highlight the recent progression in PSC technologies for the regeneration of injured heart. We review novel strategies that might overcome current obstacles in heart regenerative medicine, aiming at improving cell survival and functional integration after cell transplantation. Copyright © 2017. Published by Elsevier B.V.

  9. Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise

    Directory of Open Access Journals (Sweden)

    Robin Duelen

    2017-02-01

    Full Text Available Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment, survival and differentiation of the injected adult stem cells. The crucial challenge is identification and selection of the most suitable stem cell type for cardiac regenerative medicine. Human pluripotent stem cells (PSCs have emerged as attractive cell source to obtain cardiomyocytes (CMs, with potential applications, including drug discovery and toxicity screening, disease modelling and innovative cell therapies. Lessons from embryology offered important insights into the development of stem cell-derived CMs. However, the generation of a CM population, uniform in cardiac subtype, adult maturation and functional properties, is highly recommended. Moreover, hurdles regarding tumorigenesis, graft cell death, immune rejection and arrhythmogenesis need to be overcome in clinical practice. Here we highlight the recent progression in PSC technologies for the regeneration of injured heart. We review novel strategies that might overcome current obstacles in heart regenerative medicine, aiming at improving cell survival and functional integration after cell transplantation.

  10. Silicon solar cell technology state of the art and a proposed double sided cell

    International Nuclear Information System (INIS)

    Seddik, M.M.

    1987-08-01

    A review of the silicon technology state of the art is given. It had been found that single crystal silicon efficiency was limitd to ≥ 20%. The reason was identified to be due to the recombination current loss mechanisms. However, use of new technologies such as back-surface field, surface passivation, double anti-reflection coatings and back-surface illumination demonstrated to achieve higher efficiencies. Experiments were carried out to evaluate the effect of back surfaces illumination on the cell efficiency enhancement. It was found that for single cell, back-surface illumination contribute a 12% increase in efficiency whereas for double cell illumination (back-to-back cells) the improvement was 59% increase in efficiency. A V-shaped flat mirror reflector with optimum angle of 45 deg. to the plane of the cell from both sides achieved the ultimate efficiency performance. Finally, a proposed high current - high efficiency solar cell called ''Double Drift'' - Double Sided Illumination Cell'' was presented. The new structures were in the form of n + pn + or p + np + double junctions. The expected efficiency ranges 50-60% with proper material design, double anti-reflection coatings and V-shaped irregular plane mirror reflector illumination. (author). 43 refs, 4 figs, 7 tabs

  11. International Society for the Advancement of Cytometry cell sorter biosafety standards.

    Science.gov (United States)

    Holmes, Kevin L; Fontes, Benjamin; Hogarth, Philip; Konz, Richard; Monard, Simon; Pletcher, Charles H; Wadley, Robert B; Schmid, Ingrid; Perfetto, Stephen P

    2014-05-01

    Flow cytometric cell sorting of biological specimens has become prevalent in basic and clinical research laboratories. These specimens may contain known or unknown infectious agents, necessitating precautions to protect instrument operators and the environment from biohazards arising from the use of sorters. To this end the International Society of Analytical Cytology (ISAC) was proactive in establishing biosafety guidelines in 1997 (Schmid et al., Cytometry 1997;28:99-117) and subsequently published revised biosafety standards for cell sorting of unfixed samples in 2007 (Schmid et al., Cytometry Part A J Int Soc Anal Cytol 2007;71A:414-437). Since their publication, these documents have become recognized worldwide as the standard of practice and safety precautions for laboratories performing cell sorting experiments. However, the field of cytometry has progressed since 2007, and the document requires an update. The new Standards provides guidance: (1) for laboratory design for cell sorter laboratories; (2) for the creation of laboratory or instrument specific Standard Operating Procedures (SOP); and (3) on procedures for the safe operation of cell sorters, including personal protective equipment (PPE) and validation of aerosol containment. Published © 2014 Wiley Periodicals Inc.

  12. "The good into the pot, the bad into the crop!"--a new technology to free stem cells from feeder cells.

    Directory of Open Access Journals (Sweden)

    Annette Schneider

    Full Text Available A variety of embryonic and adult stem cell lines require an initial co-culturing with feeder cells for non-differentiated growth, self renewal and maintenance of pluripotency. However for many downstream ES cell applications the feeder cells have to be considered contaminations that might interfere not just with the analysis of experimental data but also with clinical application and tissue engineering approaches. Here we introduce a novel technique that allows for the selection of pure feeder-freed stem cells, following stem cell proliferation on feeder cell layers. Complete and reproducible separation of feeder and embryonic stem cells was accomplished by adaptation of an automated cell selection system that resulted in the aspiration of distinct cell colonies or fraction of colonies according to predefined physical parameters. Analyzing neuronal differentiation we demonstrated feeder-freed stem cells to exhibit differentiation potentials comparable to embryonic stem cells differentiated under standard conditions. However, embryoid body growth as well as differentiation of stem cells into cardiomyocytes was significantly enhanced in feeder-freed cells, indicating a feeder cell dependent modulation of lineage differentiation during early embryoid body development. These findings underline the necessity to separate stem and feeder cells before the initiation of in vitro differentiation. The complete separation of stem and feeder cells by this new technology results in pure stem cell populations for translational approaches. Furthermore, a more detailed analysis of the effect of feeder cells on stem cell differentiation is now possible, that might facilitate the identification and development of new optimized human or genetically modified feeder cell lines.

  13. Application of cell sheet technology to bone marrow stromal cell transplantation for rat brain infarct.

    Science.gov (United States)

    Ito, Masaki; Shichinohe, Hideo; Houkin, Kiyohiro; Kuroda, Satoshi

    2017-02-01

    Bone marrow stromal cells (BMSC) transplantation enhances functional recovery after cerebral infarct, but the optimal delivery route is undetermined. This study was aimed to assess whether a novel cell-sheet technology non-invasively serves therapeutic benefits to ischemic stroke. First, the monolayered cell sheet was engineered by culturing rat BMSCs on a temperature-responsive dish. The cell sheet was analysed histologically and then transplanted onto the ipsilateral neocortex of rats subjected to permanent middle cerebral artery occlusion at 7 days after the insult. Their behaviours and histology were compared with those in the animals treated with direct injection of BMSCs or vehicle over 4 weeks post-transplantation. The cell sheet was 27.9 ± 8.0 μm thick and was composed of 9.8 ± 2.4 × 10 5 cells. Cell sheet transplantation significantly improved motor function when compared with the vehicle-injected animals. Histological analysis revealed that the BMSCs were densely distributed to the neocortex adjacent to the cerebral infarct and expressed neuronal phenotype in the cell sheet-transplanted animals. These findings were almost equal to those for the animals treated with direct BMSC injection. The attachment of the BMSC sheet to the brain surface did not induce reactive astrocytes in the adjacent neocortex, although direct injection of BMSCs profoundly induced reactive astrocytes around the injection site. These findings suggest that the BMSCs in cell sheets preserve their biological capacity of migration and neural differentiation. Cell-sheet technology may enhance functional recovery after ischaemic stroke, using a less invasive method. Copyright © 2014 John Wiley & Sons, Ltd. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Questioning Faculty Use of Information Technology by Context of NETS-T Standards in Bologna Process

    Science.gov (United States)

    Elmas, Muzaffer

    2013-01-01

    Using technology in and out of class has been becoming more and more important recently. University settings also become more dependent to technology. Bologna process requires university and faculty diffuse and

  15. 75 FR 76397 - Effectiveness of Federal Agency Participation in Standardization in Select Technology Sectors for...

    Science.gov (United States)

    2010-12-08

    .... Cyber Security. 4. Emergency Communications Interoperability. 5. Radioactivity Detectors and Radiation... development. State and local governments, standards-setting organizations, industry, consumers, manufacturers... agencies work with standards-setting organizations, industry, State and local governments, and consumers to...

  16. EU Outer Borders and Radiation - An Urgent Need for Standardization, New Detector Technologies and Education Harmonization

    International Nuclear Information System (INIS)

    Prlic, Ivica; Suric Mihic, Marija; Kosmina, Domagoj; Shaw, Peter; Hajdinjak, Mladen; Cerovac, Zdravko; Bozina, Zeljko

    2014-01-01

    It appears that new IAEA transport regulations are s tarting to bite - as now there is a definite requirement for assessments of all relevant radio-nuclides in n on-equilibrium mixes': It is heard that several shipments that were either delayed significantly or rejected all together in ports in the EU. Things like synthetic rutile, zirconia, copper concentrates, and so on... Devise a NORM Passport for NORM shipments : including a text description of the material and photographs, radionuclide content plus some radiological data (dose rates, gamma spectrum and maybe also something on trigger levels for border monitoring alarms). Produce a guidance booklet for border control authorities. The two suggestions are connected, and Ii is suggested that they form a single project of how to equip the EU border contort facilities. Denial of shipment due to border alarms is an issue that affects industry- that is why it is hoped that they would be interested in being involved. Clearly it is needed to address world-wide transport (i.e. because that's where most of the NORM comes from). The whole EU outer border customs protocol is th be added to above mentioned monitoring of NORM. The new radiation technologies are used to fulfill the security issues (like stowaways, smuggling, ilicit trafficking etc..). All above mentioned forces us to standardize the customs protocols, to upgrade the education of involved workers and fo harmonize the issue throughout the EU. Croatia is a front point in the moment because of the very long and 'soft' outer EU border. (authors)

  17. A Governance Examination of Idaho's Technological Literacy Policy and Standards for Teachers: Past, Present, and Future

    Science.gov (United States)

    Moore, Terah R.

    2010-01-01

    Schools, colleges, and departments of education across America currently are investigating how preservice teachers are being prepared to use technology in the classroom. Technologies available in education have evolved but technological literacy for teachers has not always kept pace. Research suggested the need for continued development and study…

  18. Technology Strategies to Address Grade-Level Outcomes: National Standards 1 and 2

    Science.gov (United States)

    Baert, Helena

    2015-01-01

    The need to prepare students to thrive in the digital world and the benefit of using instructional technology have both been widely recognized in education. As new technology becomes available, its use by both students and teachers must be carefully evaluated. Technology can help enhance learning and facilitate the teaching process, if and when it…

  19. Academic Standards for Developing, Implementing, Evaluating, and Improving Information Science and Technology Baccalaureate Degrees

    Science.gov (United States)

    Shields-Bryant, Elayne

    2006-01-01

    The unprecedented growth, development and implementation of information technology (IT) driven by e-commerce and other technological advances have resulted in an increased demand of technology skilled workers (Reichgelt, Zhang, & Price, 2002; United States Department of Labor Bureau of Labor Statistics, 2005). In response to degree-dependent…

  20. 6. Seminar of the IIE-ININ-IMP on technological specialties. Topic 11: standards and quality assurance

    International Nuclear Information System (INIS)

    1992-01-01

    The document includes 8 papers presented at the 6. Seminar of the IIE-ININ-IMP (Mexico) on technological specialties in the field of standards and quality assurance. (Topic 11). From these, 2 papers were in INIS subject scope and a separate abstract was prepared for each of them

  1. The National Teacher Training Institute for Math, Science and Technology: Exemplary Practice in a Climate of Higher Standards.

    Science.gov (United States)

    Donlevy, James G., Ed.; Donlevy, Tia Rice, Ed.

    1999-01-01

    Reviews the NTTI (National Teacher Training Institute) for Math, Science and Technology model that trains teachers to use video and Internet resources to enhance math and science instruction. Discusses multimedia methodology; standards-based training; program impact in schools; and lesson plans available on the NTTI Web site. (Author/LRW)

  2. E-learning as a technological tool to meet the requirements of occupational standards in training of it specialists

    Science.gov (United States)

    Tokareva, N. A.; Tyatyushkina, O. Y.; Cheremisina, E. N.

    2016-09-01

    We discuss issues of updating educational programs to meet requirements of the labor market and occupational standards of IT industry. We suggest the technology of e-learning that utilizes an open educational resource to provide the employers' participation in the development of educational content and the intensification of practical training.

  3. The Making of a History Standards Wiki: "Covering", "Uncovering", and "Discovering" Curriculum Frameworks Using a Highly Interactive Technology

    Science.gov (United States)

    Maloy, Robert W.; Poirier, Michelle; Smith, Hilary K.; Edwards, Sharon A.

    2010-01-01

    This article explores using a wiki, one of the newest forms of interactive computer-based technology, as a resource for teaching the Massachusetts K-12 History and Social Science Curriculum Framework, a set of state-mandated learning standards. Wikis are web pages that can be easily edited by multiple authors. They invite active involvement by…

  4. A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells

    Science.gov (United States)

    Magness, Scott T.; Puthoff, Brent J.; Crissey, Mary Ann; Dunn, James; Henning, Susan J.; Houchen, Courtney; Kaddis, John S.; Kuo, Calvin J.; Li, Linheng; Lynch, John; Martin, Martin G.; May, Randal; Niland, Joyce C.; Olack, Barbara; Qian, Dajun; Stelzner, Matthias; Swain, John R.; Wang, Fengchao; Wang, Jiafang; Wang, Xinwei; Yan, Kelley; Yu, Jian

    2013-01-01

    Fluorescence-activated cell sorting (FACS) is an essential tool for studies requiring isolation of distinct intestinal epithelial cell populations. Inconsistent or lack of reporting of the critical parameters associated with FACS methodologies has complicated interpretation, comparison, and reproduction of important findings. To address this problem a comprehensive multicenter study was designed to develop guidelines that limit experimental and data reporting variability and provide a foundation for accurate comparison of data between studies. Common methodologies and data reporting protocols for tissue dissociation, cell yield, cell viability, FACS, and postsort purity were established. Seven centers tested the standardized methods by FACS-isolating a specific crypt-based epithelial population (EpCAM+/CD44+) from murine small intestine. Genetic biomarkers for stem/progenitor (Lgr5 and Atoh 1) and differentiated cell lineages (lysozyme, mucin2, chromogranin A, and sucrase isomaltase) were interrogated in target and control populations to assess intra- and intercenter variability. Wilcoxon's rank sum test on gene expression levels showed limited intracenter variability between biological replicates. Principal component analysis demonstrated significant intercenter reproducibility among four centers. Analysis of data collected by standardized cell isolation methods and data reporting requirements readily identified methodological problems, indicating that standard reporting parameters facilitate post hoc error identification. These results indicate that the complexity of FACS isolation of target intestinal epithelial populations can be highly reproducible between biological replicates and different institutions by adherence to common cell isolation methods and FACS gating strategies. This study can be considered a foundation for continued method development and a starting point for investigators that are developing cell isolation expertise to study physiology and

  5. Development of molten-carbonate fuel-cell technology. Final report, February-December 1980

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    The objective of the work was to focus on the basic technology for producing molten carbonate fuel cell (MCFC) components. This included the development and fabrication of stable anode structures, preparation of lithiated nickel oxide cathodes, synthesis and characterization of a high surface area (gamma-lithium-aluminate) electrolyte support, pressurized cell testing and modeling of the overall electrolyte distribution within a cell to aid performance optimization of the different cell components. The electrode development program is highlighted by two successful 5000 hour bench-scale tests using stabilized anode structures. One of these provided better performance than in any previous state-of-the-art, bench-scale cell (865 mV at 115 mA/cm/sup 2/ under standard conditions). Pressurized testing at 10 atmosphere of a similar stabilized, high surface area, Ni/Co anode structure in a 300 cm/sup 2/ cell showed that the 160 mA/cm/sup 2/ performance goal of 850 mV on low Btu fuel (80% conversion) can be readily met. A study of the H/sub 2/S-effects on molten carbonate fuel cells showed that ERC's Ni/Co anode provided better tolerance than a Ni/Cr anode. Prelithiated nickel oxide plaques were prepared from materials made by a low temperature and a high temperature powder-production process. The methods for fabricating handleable cathodes of various thicknesses were also investigated. In electrolyte matrix development, accelerated out-of-cell and in-cell tests have confirmed the superior stability of ..gamma..-LiAlO/sub 2/.

  6. Comparative Analysis of Dynamic Cell Viability, Migration and Invasion Assessments by Novel Real-Time Technology and Classic Endpoint Assays

    Science.gov (United States)

    Limame, Ridha; Wouters, An; Pauwels, Bea; Fransen, Erik; Peeters, Marc; Lardon, Filip; De Wever, Olivier; Pauwels, Patrick

    2012-01-01

    Background Cell viability and motility comprise ubiquitous mechanisms involved in a variety of (patho)biological processes including cancer. We report a technical comparative analysis of the novel impedance-based xCELLigence Real-Time Cell Analysis detection platform, with conventional label-based endpoint methods, hereby indicating performance characteristics and correlating dynamic observations of cell proliferation, cytotoxicity, migration and invasion on cancer cells in highly standardized experimental conditions. Methodology/Principal Findings Dynamic high-resolution assessments of proliferation, cytotoxicity and migration were performed using xCELLigence technology on the MDA-MB-231 (breast cancer) and A549 (lung cancer) cell lines. Proliferation kinetics were compared with the Sulforhodamine B (SRB) assay in a series of four cell concentrations, yielding fair to good correlations (Spearman's Rho 0.688 to 0.964). Cytotoxic action by paclitaxel (0–100 nM) correlated well with SRB (Rho>0.95) with similar IC50 values. Reference cell migration experiments were performed using Transwell plates and correlated by pixel area calculation of crystal violet-stained membranes (Rho 0.90) and optical density (OD) measurement of extracted dye (Rho>0.95). Invasion was observed on MDA-MB-231 cells alone using Matrigel-coated Transwells as standard reference method and correlated by OD reading for two Matrigel densities (Rho>0.95). Variance component analysis revealed increased variances associated with impedance-based detection of migration and invasion, potentially caused by the sensitive nature of this method. Conclusions/Significance The xCELLigence RTCA technology provides an accurate platform for non-invasive detection of cell viability and motility. The strong correlations with conventional methods imply a similar observation of cell behavior and interchangeability with other systems, illustrated by the highly correlating kinetic invasion profiles on different

  7. Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays.

    Directory of Open Access Journals (Sweden)

    Ridha Limame

    Full Text Available BACKGROUND: Cell viability and motility comprise ubiquitous mechanisms involved in a variety of (pathobiological processes including cancer. We report a technical comparative analysis of the novel impedance-based xCELLigence Real-Time Cell Analysis detection platform, with conventional label-based endpoint methods, hereby indicating performance characteristics and correlating dynamic observations of cell proliferation, cytotoxicity, migration and invasion on cancer cells in highly standardized experimental conditions. METHODOLOGY/PRINCIPAL FINDINGS: Dynamic high-resolution assessments of proliferation, cytotoxicity and migration were performed using xCELLigence technology on the MDA-MB-231 (breast cancer and A549 (lung cancer cell lines. Proliferation kinetics were compared with the Sulforhodamine B (SRB assay in a series of four cell concentrations, yielding fair to good correlations (Spearman's Rho 0.688 to 0.964. Cytotoxic action by paclitaxel (0-100 nM correlated well with SRB (Rho>0.95 with similar IC(50 values. Reference cell migration experiments were performed using Transwell plates and correlated by pixel area calculation of crystal violet-stained membranes (Rho 0.90 and optical density (OD measurement of extracted dye (Rho>0.95. Invasion was observed on MDA-MB-231 cells alone using Matrigel-coated Transwells as standard reference method and correlated by OD reading for two Matrigel densities (Rho>0.95. Variance component analysis revealed increased variances associated with impedance-based detection of migration and invasion, potentially caused by the sensitive nature of this method. CONCLUSIONS/SIGNIFICANCE: The xCELLigence RTCA technology provides an accurate platform for non-invasive detection of cell viability and motility. The strong correlations with conventional methods imply a similar observation of cell behavior and interchangeability with other systems, illustrated by the highly correlating kinetic invasion profiles on

  8. Performance assessment of select covers and disposal cell compliance with EPA [Environmental Protection Agency] groundwater standards

    International Nuclear Information System (INIS)

    1989-06-01

    This document describes the technical approach to the assessment of the performance of a full component topslope cover, three sideslope covers, and hence the way in which a Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cell complies with the US Environmental Protection Agency (EPA) groundwater protection standards. 4 refs

  9. Development of a Standard Test to Assess the Resistance of Staphylococcus aureus Biofilm Cells to Disinfectants

    NARCIS (Netherlands)

    Luppens, S.B.I.; Reij, M.W.; Heijden, van der R.W.; Rombouts, F.M.; Abee, T.

    2002-01-01

    A standardized disinfectant test for Staphylococcus aureus cells in biofilms was developed. Two disinfectants, the membrane-active compound benzalkonium chloride (BAC) and the oxidizing agent sodium hypochlorite, were used to evaluate the biofilm test. S. aureus formed biofilms on glass, stainless

  10. A standard methodology for cost-effectiveness analysis of new environmental technologies

    International Nuclear Information System (INIS)

    Booth, S.R.; Trocki, L.K.; Bowling, L.

    1994-01-01

    This paper outlines a methodology that is being applied to assess the cost-effectiveness of new environmental technologies under development by EM-50, DOE. Performance, total system effects, and life-cycle costs are all considered in the methodology to compare new technologies with existing or base-line technologies. An example of performance characterization is given in the paper. Sources of data for cost estimates and technology characterizations also appear in the paper. The Department of Energy (DOE) is facing a massive clean up effort of waste sites that contain hazardous, radioactive, or mixed materials. DOE has recognized that improvements in environmental restoration and waste management methods can potentially save the taxpayers billions of dollars as older, less-effective technologies are displaced. Consequently, DOE has targeted significant funding to search for new technologies and to test and demonstrate them in rapid and cost-effective manner with the goal of applying them quickly to address environmental problems

  11. 76 FR 3877 - Effectiveness of Federal Agency Participation in Standardization in Select Technology Sectors for...

    Science.gov (United States)

    2011-01-21

    .... Health Information Technology. 3. Cyber Security. 4. Emergency Communications Interoperability. 5... and Business Affairs at [email protected] or 301-975-NIST (6478). SUPPLEMENTARY INFORMATION: On...

  12. Assessment of the competing technologies to fuel cells in the stationary power and CHP markets

    Energy Technology Data Exchange (ETDEWEB)

    Pears, T.J.

    1999-07-01

    This report summarises the results of a study assessing the commercial technologies that are likely to compete with fuel cells in the fields of stationary power and cogeneration markets. The competing technologies examined include clean coal technologies, reciprocating engines, gas turbines, microturbines, and stirling engines. Energy and environmental legislation, and the ranking of the competing technologies are discussed. (UK)

  13. Pathways to Commercial Success: Technologies and Products Supported by the Hydrogen, Fuel Cells and Infrastructure Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-08-01

    This report documents the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Hydrogen, Fuel Cells and Infrastructure Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  14. Photovoltaic cell and array technology development for future unique NASA missions

    Science.gov (United States)

    Bailey, S.; Curtis, H.; Piszczor, M.; Surampudi, R.; Hamilton, T.; Rapp, D.; Stella, P.; Mardesich, N.; Mondt, J.; Bunker, R.; hide

    2002-01-01

    A technology review committee from NASA, the U.S. Department of Energy (DOE), and the Air Force Research Lab, was formed to assess solar cell and array technologies required for future NASA science missions.

  15. 3D Technology Selection for a Virtual Learning Environment by Blending ISO 9126 Standard and AHP

    Science.gov (United States)

    Cetin, Aydin; Guler, Inan

    2011-01-01

    Web3D presents many opportunities for learners in a virtual world or virtual environment over the web. This is a great opportunity for open-distance education institutions to benefit from web3d technologies to create courses with interactive 3d materials. There are many open source and commercial products offering 3d technologies over the web…

  16. Standardized 3D Bioprinting of Soft Tissue Models with Human Primary Cells.

    Science.gov (United States)

    Rimann, Markus; Bono, Epifania; Annaheim, Helene; Bleisch, Matthias; Graf-Hausner, Ursula

    2016-08-01

    Cells grown in 3D are more physiologically relevant than cells cultured in 2D. To use 3D models in substance testing and regenerative medicine, reproducibility and standardization are important. Bioprinting offers not only automated standardizable processes but also the production of complex tissue-like structures in an additive manner. We developed an all-in-one bioprinting solution to produce soft tissue models. The holistic approach included (1) a bioprinter in a sterile environment, (2) a light-induced bioink polymerization unit, (3) a user-friendly software, (4) the capability to print in standard labware for high-throughput screening, (5) cell-compatible inkjet-based printheads, (6) a cell-compatible ready-to-use BioInk, and (7) standard operating procedures. In a proof-of-concept study, skin as a reference soft tissue model was printed. To produce dermal equivalents, primary human dermal fibroblasts were printed in alternating layers with BioInk and cultured for up to 7 weeks. During long-term cultures, the models were remodeled and fully populated with viable and spreaded fibroblasts. Primary human dermal keratinocytes were seeded on top of dermal equivalents, and epidermis-like structures were formed as verified with hematoxylin and eosin staining and immunostaining. However, a fully stratified epidermis was not achieved. Nevertheless, this is one of the first reports of an integrative bioprinting strategy for industrial routine application. © 2015 Society for Laboratory Automation and Screening.

  17. Information technology Governance standards on mobile applications for fishing zone based onCobIT 5 Framework in Majene

    Science.gov (United States)

    Palalloi, Irfan Andi; Anwar, Azwar; Syarifuddin

    2018-05-01

    Most of the activities of Majene regency society dominant as a fisherman, by and large, they work based on the hereditary experiences of their ancestors. This is proven by fishery industry statistic that highest from other industry with 18,30 % in the distribution of the gross regional domestic product. In each specific case, utilization of technology becomes a necessity that plays a key role. Adoption of technology for fishermen groups in use of GPSequipment has frequently committed by the government also non-profit organization go through training and mentoring. Nowadays there are some modern mobile applications has been developed by government agency assist the group of fishermen handy on managing their fishing activity. Such us ZPPI data row from Lapan Satelite, nelpinwas also known as smart fisheries, infrastructure development for space oceanography (indeso). However, all of them carry out of the risk and problems on the user side. One of them related toaccuracy and reliability. In this research, we elaborate technical factor, governance, through Cobit framework and analyze the best practice standardfor implementing the technology. All in all, the result presented of the governance standard on control and implementing technology under customer dimension in information technology governance on the standard process to ensure benefit delivery for implementing mobile application fishery in DKP Majene regency.

  18. Image sensor pixel with on-chip high extinction ratio polarizer based on 65-nm standard CMOS technology.

    Science.gov (United States)

    Sasagawa, Kiyotaka; Shishido, Sanshiro; Ando, Keisuke; Matsuoka, Hitoshi; Noda, Toshihiko; Tokuda, Takashi; Kakiuchi, Kiyomi; Ohta, Jun

    2013-05-06

    In this study, we demonstrate a polarization sensitive pixel for a complementary metal-oxide-semiconductor (CMOS) image sensor based on 65-nm standard CMOS technology. Using such a deep-submicron CMOS technology, it is possible to design fine metal patterns smaller than the wavelengths of visible light by using a metal wire layer. We designed and fabricated a metal wire grid polarizer on a 20 × 20 μm(2) pixel for image sensor. An extinction ratio of 19.7 dB was observed at a wavelength 750 nm.

  19. Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy

    DEFF Research Database (Denmark)

    Hansen, Morten; Hjortø, Gertrud Malene; Donia, Marco

    2013-01-01

    induction of type 1 effector T cells. Standard matured clinical grade DCs “sDCs” were compared with DCs matured with either of two type 1 polarizing maturation cocktails; the alpha-type-1 DCs “αDC1s” (TNF-α, IL-1β, IFN-γ, IFN-α, Poly(I:C)) and “mDCs” (monophosphoryl lipid A (MPL), IFN-γ) or a mixed cocktail...... – “mpDCs”, containing MPL, IFN-γ and PGE2. αDC1s and mDCs secreted IL-12 directly and following re-stimulation with CD40L-expressing cells and they mainly secreted the T effector cell attracting chemokines CXCL10 and CCL5 as opposed to sDCs that mainly secreted CCL22, known to attract regulatory T cells...

  20. Fundamentals of automotive and engine technology standard drives, hybrid drives, brakes, safety systems

    CERN Document Server

    2014-01-01

    Hybrid drives and the operation of hybrid vehicles are characteristic of contemporary automotive technology. Together with the electronic driver assistant systems, hybrid technology is of the greatest importance and both cannot be ignored by today’s car drivers. This technical reference book provides the reader with a firsthand comprehensive description of significant components of automotive technology. All texts are complemented by numerous detailed illustrations. Contents History of the automobile.- History of the Diesel engine.- Areas of use for Diesel engines.- Basic principles of the Diesel engine.- Basic principles of Diesel fuel-injection.- Basic principles of the gasoline engine.- Inductive ignition system.- Transmissions for motor vehicles.- Motor vehicle safety.- Basic principles of vehicle dynamics.- Car braking systems.- Vehicle electrical systems.- Overview of electrical and electronic systems in the vehicle.- Control of gasoline engines.- Control of Diesel engines.- Lighting technology.- Elec...

  1. National Institute of Standards and Technology (NIST) cybersecurity risk management framework applied to modern vehicles

    Science.gov (United States)

    2014-10-01

    The primary objective of the work described in this report is to review the National Institute of Science and Technology (NIST) guidelines and foundational publications from an automotive : cybersecurity risk management stand-point. The NIST approach...

  2. A brain-computer interface as input channel for a standard assistive technology software.

    Science.gov (United States)

    Zickler, Claudia; Riccio, Angela; Leotta, Francesco; Hillian-Tress, Sandra; Halder, Sebastian; Holz, Elisa; Staiger-Sälzer, Pit; Hoogerwerf, Evert-Jan; Desideri, Lorenzo; Mattia, Donatella; Kübler, Andrea

    2011-10-01

    Recently brain-computer interface (BCI) control was integrated into the commercial assistive technology product QualiWORLD (QualiLife Inc., Paradiso-Lugano, CH). Usability of the first prototype was evaluated in terms of effectiveness (accuracy), efficiency (information transfer rate and subjective workload/NASA Task Load Index) and user satisfaction (Quebec User Evaluation of Satisfaction with assistive Technology, QUEST 2.0) by four end-users with severe disabilities. Three assistive technology experts evaluated the device from a third person perspective. The results revealed high performance levels in communication and internet tasks. Users and assistive technology experts were quite satisfied with the device. However, none could imagine using the device in daily life without improvements. Main obstacles were the EEG-cap and low speed.

  3. Wright meets Markowitz: How standard portfolio theory changes when assets are technologies following experience curves

    OpenAIRE

    Way, Rupert; Lafond, François; Farmer, J. Doyne; Lillo, Fabrizio; Panchenko, Valentyn

    2017-01-01

    This paper considers how to optimally allocate investments in a portfolio of competing technologies. We introduce a simple model representing the underlying trade-off - between investing enough effort in any one project to spur rapid progress, and diversifying effort over many projects simultaneously to hedge against failure. We use stochastic experience curves to model the idea that investing more in a technology reduces its unit costs, and we use a mean-variance objective function to unders...

  4. 77 FR 13831 - Health Information Technology: Standards, Implementation Specifications, and Certification...

    Science.gov (United States)

    2012-03-07

    ..., including potentially greater standardization and automation.'' The HITPC also recommended that this... Statement for Secure Health Transport) and Sec. 170.202(a)(2) (XDR and XDM for Direct Messaging); and Sec...

  5. Standard cell-based implementation of a digital optoelectronic neural-network hardware.

    Science.gov (United States)

    Maier, K D; Beckstein, C; Blickhan, R; Erhard, W

    2001-03-10

    A standard cell-based implementation of a digital optoelectronic neural-network architecture is presented. The overall structure of the multilayer perceptron network that was used, the optoelectronic interconnection system between the layers, and all components required in each layer are defined. The design process from VHDL-based modeling from synthesis and partly automatic placing and routing to the final editing of one layer of the circuit of the multilayer perceptrons are described. A suitable approach for the standard cell-based design of optoelectronic systems is presented, and shortcomings of the design tool that was used are pointed out. The layout for the microelectronic circuit of one layer in a multilayer perceptron neural network with a performance potential 1 magnitude higher than neural networks that are purely electronic based has been successfully designed.

  6. Using technology to promote mobile learning: engaging students with cell phones in the classroom.

    Science.gov (United States)

    Robb, Meigan; Shellenbarger, Teresa

    2012-01-01

    Advancements in cell phone technology have impacted every aspect of society. Individuals have instant access to social networks, Web sites, and applications. Faculty need to consider using these mobile devices to enrich the classroom. The authors discuss how they successfully designed and incorporated cell phone learning activities into their classrooms. Teaching-learning strategies using cell phone technology and recommendations for overcoming challenges associated with cell phone use in the classroom are discussed.

  7. Standard Specification for Physical Characteristics of Nonconcentrator Terrestrial Photovoltaic Reference Cells

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 This specification describes the physical requirements for primary and secondary terrestrial nonconcentrator photovoltaic reference cells. A reference cell is defined as a device that meets the requirements of this specification and is calibrated in accordance with Test Method E1125 or Test Method E1362. 1.2 Reference cells are used in the determination of the electrical performance of photovoltaic devices, as stated in Test Methods E948 and E1036. 1.3 Two reference cell physical specifications are described: 1.3.1 Small-Cell Package Design—A small, durable package with a low thermal mass, wide optical field-of-view, and standardized dimensions intended for photovoltaic devices up to 20 by 20 mm, and 1.3.2 Module-Package Design—A package intended to simulate the optical and thermal properties of a photovoltaic module design, but electric connections are made to only one photovoltaic cell in order to eliminate problems with calibrating series and parallel connections of cells. Physical dimensions ...

  8. Current Standards of Care and Long Term Outcomes for Thalassemia and Sickle Cell Disease.

    Science.gov (United States)

    Chonat, Satheesh; Quinn, Charles T

    2017-01-01

    Thalassemia and sickle cell disease (SCD) are disorders of hemoglobin that affect millions of people worldwide. The carrier states for these diseases arose as common, balanced polymorphisms during human history because they afforded protection against severe forms of malaria. These complex, multisystem diseases are reviewed here with a focus on current standards of clinical management and recent research findings. The importance of a comprehensive, multidisciplinary and lifelong system of care is also emphasized.

  9. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

    Directory of Open Access Journals (Sweden)

    Anke Fuchs

    2018-01-01

    Full Text Available Cellular therapies with CD4+ T regulatory cells (Tregs hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG. It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.

  10. Utilizing GIS to Examine the Relationship Between State Renewable Portfolio Standards and the Adoption of Renewable Energy Technologies

    Directory of Open Access Journals (Sweden)

    Chelsea Schelly

    2013-12-01

    Full Text Available In the United States, there is no comprehensive energy policy at the federal level. To address issues as diverse as climate change, energy security, and economic development, individual states have increasingly implemented Renewable Portfolio Standards (RPSs, which mandate that utility providers include a specified amount of electricity from renewable energy sources in their total energy portfolios. Some states have included incentives for individual energy technologies in their RPS, such as solar electric (also called photovoltaic or PV technology. Here, we use GIS to visualize adoption of RPSs and electricity generation from renewable energy sources in the US and examine changes in renewable electricity and solar electric generation over time with the goal of informing future policies aimed at promoting the adoption of renewable energy technologies.

  11. DARPA Antibody Technology Program. Standardized Test Bed for Antibody Characterization: Characterization of an MS2 ScFv Antibody Produced by Illumina

    Science.gov (United States)

    2016-08-01

    ECBC-TR-1395 DARPA ANTIBODY TECHNOLOGY PROGRAM STANDARDIZED TEST BED FOR... ANTIBODY CHARACTERIZATION: CHARACTERIZATION OF AN MS2 SCFV ANTIBODY PRODUCED BY ILLUMINA Patricia E. Buckley Alena M. Calm Heather Welsh Roy...4. TITLE AND SUBTITLE DARPA Antibody Technology Program Standardized Test Bed for Antibody Characterization: Characterization of an MS2 ScFv

  12. Preliminary study of steep pulse irreversible electroporation technology in human large cell lung cancer cell lines L9981

    Directory of Open Access Journals (Sweden)

    Song Zuoqing

    2013-01-01

    Full Text Available Our aim was to validate the effectiveness of steep pulse irreversible electroporation technology in human large cell lung cancer cells and to screen the optimal treatment of parameters for human large cell lung cancer cells. Three different sets of steep pulse therapy parameters were applied on the lung cancer cell line L9981. The cell line L9981 inhibition rate and proliferation capacity were detected by Vi-Cell vitality analysis and MTT. Steep pulsed irreversible electroporation technology for large cell lung cancer L9981 presents killing effects with various therapy parameters. The optimal treatment parameters are at a voltage amplitude of 2000V/cm, pulse width of 100μs, pulse frequency of 1 Hz, pulse number 10. With this group of parameters, steep pulse could have the best tumor cell-killing effects.

  13. Cornell Fuel Cell Institute: Materials Discovery to Enable Fuel Cell Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Abruna, H.D.; DiSalvo, Francis J.

    2012-06-29

    The discovery and understanding of new, improved materials to advance fuel cell technology are the objectives of the Cornell Fuel Cell Institute (CFCI) research program. CFCI was initially formed in 2003. This report highlights the accomplishments from 2006-2009. Many of the grand challenges in energy science and technology are based on the need for materials with greatly improved or even revolutionary properties and performance. This is certainly true for fuel cells, which have the promise of being highly efficient in the conversion of chemical energy to electrical energy. Fuel cells offer the possibility of efficiencies perhaps up to 90 % based on the free energy of reaction. Here, the challenges are clearly in the materials used to construct the heart of the fuel cell: the membrane electrode assembly (MEA). The MEA consists of two electrodes separated by an ionically conducting membrane. Each electrode is a nanocomposite of electronically conducting catalyst support, ionic conductor and open porosity, that together form three percolation networks that must connect to each catalyst nanoparticle; otherwise the catalyst is inactive. This report highlights the findings of the three years completing the CFCI funding, and incudes developments in materials for electrocatalyts, catalyst supports, materials with structured and functional porosity for electrodes, and novel electrolyte membranes. The report also discusses developments at understanding electrocatalytic mechanisms, especially on novel catalyst surfaces, plus in situ characterization techniques and contributions from theory. Much of the research of the CFCI continues within the Energy Materials Center at Cornell (emc2), a DOE funded, Office of Science Energy Frontier Research Center (EFRC).

  14. Results of the PEP`93 intercomparison of reference cell calibrations and newer technology performance measurements

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R.; Emery, K. [National Renewable Energy Lab., Golden, CO (United States); Anevsky, S. [All-Union Research Inst. for Optophysical Measurements, Moscow (Russian Federation)] [and others

    1996-05-01

    This paper presents the results of an international intercomparison of photovoltaic (PV) performance measurements and calibrations. The intercomparison, which was organized and operated by a group of experts representing national laboratories from across the globe (i.e., the authors of this paper), was accomplished by circulating two sample sets. One set consisted of twenty silicon reference cells that would, hopefully, form the basis of an international PV reference scale. A qualification procedure applied to the calibration results gave average calibration numbers with an overall standard deviation of less than 2% for the entire set. The second set was assembled from a wide range of newer technologies that present unique problems for PV measurements. As might be expected, these results showed much larger differences among laboratories. Methods were then identified that should be used to measure such devices, along with problems to avoid.

  15. Cell Surface and Membrane Engineering: Emerging Technologies and Applications

    Directory of Open Access Journals (Sweden)

    Christopher T. Saeui

    2015-06-01

    Full Text Available Membranes constitute the interface between the basic unit of life—a single cell—and the outside environment and thus in many ways comprise the ultimate “functional biomaterial”. To perform the many and often conflicting functions required in this role, for example to partition intracellular contents from the outside environment while maintaining rapid intake of nutrients and efflux of waste products, biological membranes have evolved tremendous complexity and versatility. This article describes how membranes, mainly in the context of living cells, are increasingly being manipulated for practical purposes with drug discovery, biofuels, and biosensors providing specific, illustrative examples. Attention is also given to biology-inspired, but completely synthetic, membrane-based technologies that are being enabled by emerging methods such as bio-3D printers. The diverse set of applications covered in this article are intended to illustrate how these versatile technologies—as they rapidly mature—hold tremendous promise to benefit human health in numerous ways ranging from the development of new medicines to sensitive and cost-effective environmental monitoring for pathogens and pollutants to replacing hydrocarbon-based fossil fuels.

  16. Cell Surface and Membrane Engineering: Emerging Technologies and Applications

    Science.gov (United States)

    Saeui, Christopher T.; Mathew, Mohit P.; Liu, Lingshui; Urias, Esteban; Yarema, Kevin J.

    2015-01-01

    Membranes constitute the interface between the basic unit of life—a single cell—and the outside environment and thus in many ways comprise the ultimate “functional biomaterial”. To perform the many and often conflicting functions required in this role, for example to partition intracellular contents from the outside environment while maintaining rapid intake of nutrients and efflux of waste products, biological membranes have evolved tremendous complexity and versatility. This article describes how membranes, mainly in the context of living cells, are increasingly being manipulated for practical purposes with drug discovery, biofuels, and biosensors providing specific, illustrative examples. Attention is also given to biology-inspired, but completely synthetic, membrane-based technologies that are being enabled by emerging methods such as bio-3D printers. The diverse set of applications covered in this article are intended to illustrate how these versatile technologies—as they rapidly mature—hold tremendous promise to benefit human health in numerous ways ranging from the development of new medicines to sensitive and cost-effective environmental monitoring for pathogens and pollutants to replacing hydrocarbon-based fossil fuels. PMID:26096148

  17. Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line.

    Science.gov (United States)

    Vaseghi, Golnaz; Taki, Mohamad Javad; Javanmard, Shaghayegh Haghjooy

    2017-10-01

    Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardized Cannabis sativa extract on cell migration and Tau and Stathmin gene expression in the melanoma cell line. In the treatment group, melanoma (B1617) was treated 48 hr with various concentrations of standardized C. sativa extract. Cells with no treatment were considered as the control group, then study was followed by Quantitative RT-Real Time PCR assay. Relative gene expression was calculated by the ΔΔct method. Migration assay was used to evaluate cancer metastasis. Tau and stathmin gene expression was significantly decreased compared to the control group. Cell migration was also significantly reduced compared to controls. C. sativa decreased tau and stathmin gene expression and cancer metastasis. The results may have some clinical relevance for the use of cannabis-based medicines in patients with metastatic melanoma.

  18. Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line

    Directory of Open Access Journals (Sweden)

    Golnaz Vaseghi

    2017-10-01

    Full Text Available Objective(s: Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardized Cannabis sativa extract on cell migration and Tau and Stathmin gene expression in the melanoma cell line. Materials and Methods: In the treatment group, melanoma (B1617 was treated 48 hr with various concentrations of standardized C. sativa extract. Cells with no treatment were considered as the control group, then study was followed by Quantitative RT-Real Time PCR assay. Relative gene expression was calculated by the ΔΔct method. Migration assay was used to evaluate cancer metastasis. Results: Tau and stathmin gene expression was significantly decreased compared to the control group. Cell migration was also significantly reduced compared to controls.  Conclusion: C. sativa decreased tau and stathmin gene expression and cancer metastasis.  The results may have some clinical relevance for the use of cannabis-based medicines in patients with metastatic melanoma.

  19. Biological effects of tritium on fish cells in the concentration range of international drinking water standards.

    Science.gov (United States)

    Stuart, Marilyne; Festarini, Amy; Schleicher, Krista; Tan, Elizabeth; Kim, Sang Bog; Wen, Kendall; Gawlik, Jilian; Ulsh, Brant

    2016-10-01

    To evaluate whether the current Canadian tritium drinking water limit is protective of aquatic biota, an in vitro study was designed to assess the biological effects of low concentrations of tritium, similar to what would typically be found near a Canadian nuclear power station, and higher concentrations spanning the range of international tritium drinking water standards. Channel catfish peripheral blood B-lymphoblast and fathead minnow testis cells were exposed to 10-100,000 Bq l(-1) of tritium, after which eight molecular and cellular endpoints were assessed. Increased numbers of DNA strand breaks were observed and ATP levels were increased. There were no increases in γH2AX-mediated DNA repair. No differences in cell growth were noted. Exposure to the lowest concentrations of tritium were associated with a modest increase in the viability of fathead minnow testicular cells. Using the micronucleus assay, an adaptive response was observed in catfish B-lymphoblasts. Using molecular endpoints, biological responses to tritium in the range of Canadian and international drinking water standards were observed. At the cellular level, no detrimental effects were noted on growth or cycling, and protective effects were observed as an increase in cell viability and an induced resistance to a large challenge dose.

  20. Radiation-based quantitative bioimaging at the national institute of standards and technology

    Directory of Open Access Journals (Sweden)

    Karam Lisa

    2009-01-01

    Full Text Available Building on a long history of providing physical measurements and standards for medical x rays and nuclear medicine radionuclides, the laboratory has expanded its focus to better support the extensive use of medical physics in the United States today, providing confidence in key results needed for drug and device development and marketing, therapy planning and efficacy and disease screening. In particular, to support more quantitative medical imaging, this laboratory has implemented a program to provide key measurement infrastructure to support radiation-based imaging through developing standard, benchmark phantoms, which contain radioactive sources calibrated to national measurement standards, to allow more quantitative imaging through traceable instrument calibration for clinical trials or patient management. Working closely with colleagues at the National Institutes of Health, Rensselaer Polytechnic Institute, the Food and Drug Administration and Cornell University, this laboratory has taken the initial steps in developing phantoms, and the protocols to use them, for more accurate calibration of positron emission tomography (PET or single-photon emission computed tomography (SPECT cameras, including recently standardizing 68 Ge. X-ray measurements of the laboratory′s recently developed small, resilient and inexpensive length standard phantom have shown the potential usefulness of such a "pocket" phantom for patient-based calibration of computed tomography (alone or with PET systems. The ability to calibrate diagnostic imaging tools in a way that is traceable to national standards will lead to a more quantitative approach; both physician and patient benefit from increased accuracy in treatment planning, as well as increased safety for the patient.

  1. Process engineering and economic evaluations of diaphragm and membrane chlorine cell technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The chlor-alkali manufacturing technologies of (1), diaphragm cells (2), current technology membrane cells (3), catalytic cathode membrane cells (4), oxygen-cathode membrane cells and to a lesser extent several other related emerging processes are studied. Comparisons have been made on the two bases of (1) conventional industrial economics, and (2) energy consumption. The current diaphragm cell may have a small economic advantage over the other technologies at the plant size of 544 metric T/D (600 T/D). The three membrane cells all consume less energy, with the oxygen-cathode cell being the lowest. The oxygen-cathode cell appears promising as a low energy chlor-alkali cell where there is no chemical market for hydrogen. Federal funding of the oxygen-cathode cell has been beneficial to the development of the technology, to electrochemical cell research, and may help maintain the US's position in the international chlor-alkali technology marketplace. Tax law changes inducing the installation of additional cells in existing plants would produce the quickest reduction in power consumption by the chlor-alkali industry. Alternative technologies such as the solid polymer electrolyte cell, the coupling of diaphragm cells with fuel cells and the dynamic gel diaphragm have a strong potential for reducing chloralkali industry power consumption. Adding up all the recent and expected improvements that have become cost-effective, the electrical energy required to produce a unit of chlorine by 1990 should be only 50% to 60% of that used in 1970. In the United States the majority of the market does not demand salt-free caustic. About 75% of the electrolytic caustic is produced in diaphragm cells and only a small part of that is purified. This study indicates that unless membrane cell costs are greatly reduced or a stronger demand develops for salt-free caustic, the diaphragm cells will remain competitive. (WHK)

  2. Experimental design and reporting standards for metabolomics studies of mammalian cell lines.

    Science.gov (United States)

    Hayton, Sarah; Maker, Garth L; Mullaney, Ian; Trengove, Robert D

    2017-12-01

    Metabolomics is an analytical technique that investigates the small biochemical molecules present within a biological sample isolated from a plant, animal, or cultured cells. It can be an extremely powerful tool in elucidating the specific metabolic changes within a biological system in response to an environmental challenge such as disease, infection, drugs, or toxins. A historically difficult step in the metabolomics pipeline is in data interpretation to a meaningful biological context, for such high-variability biological samples and in untargeted metabolomics studies that are hypothesis-generating by design. One way to achieve stronger biological context of metabolomic data is via the use of cultured cell models, particularly for mammalian biological systems. The benefits of in vitro metabolomics include a much greater control of external variables and no ethical concerns. The current concerns are with inconsistencies in experimental procedures and level of reporting standards between different studies. This review discusses some of these discrepancies between recent studies, such as metabolite extraction and data normalisation. The aim of this review is to highlight the importance of a standardised experimental approach to any cultured cell metabolomics study and suggests an example procedure fully inclusive of information that should be disclosed in regard to the cell type/s used and their culture conditions. Metabolomics of cultured cells has the potential to uncover previously unknown information about cell biology, functions and response mechanisms, and so the accurate biological interpretation of the data produced and its ability to be compared to other studies should be considered vitally important.

  3. A comparative analysis of Science-Technology-Society standards in elementary, middle and high school state science curriculum frameworks

    Science.gov (United States)

    Tobias, Karen Marie

    An analysis of curriculum frameworks from the fifty states to ascertain the compliance with the National Science Education Standards for integrating Science-Technology-Society (STS) themes is reported within this dissertation. Science standards for all fifty states were analyzed to determine if the STS criteria were integrated at the elementary, middle, and high school levels of education. The analysis determined the compliance level for each state, then compared each educational level to see if the compliance was similar across the levels. Compliance is important because research shows that using STS themes in the science classroom increases the student's understanding of the concepts, increases the student's problem solving skills, increases the student's self-efficacy with respect to science, and students instructed using STS themes score well on science high stakes tests. The two hypotheses for this study are: (1) There is no significant difference in the degree of compliance to Science-Technology-Society themes (derived from National Science Education Standards) between the elementary, middle, and high school levels. (2) There is no significant difference in the degree of compliance to Science-Technology-Society themes (derived from National Science Education Standards) between the elementary, middle, and high school level when examined individually. The Analysis of Variance F ratio was used to determine the variance between and within the three educational levels. This analysis addressed hypothesis one. The Analysis of Variance results refused to reject the null hypothesis, meaning there is significant difference in the compliance to STS themes between the elementary, middle and high school educational levels. The Chi-Square test was the statistical analysis used to compare the educational levels for each individual criterion. This analysis addressed hypothesis two. The Chi-Squared results showed that none of the states were equally compliant with each

  4. Standards for Technological Literacy and STEM Education Delivery through Career and Technical Education Programs

    Science.gov (United States)

    Asunda, Paul A.

    2012-01-01

    At a minimum, employers rely on career and technical education (CTE) and workforce training systems to supply workers able to perform in their jobs. In CTE classes that seek to integrate science, technology, engineering, and mathematics (STEM) concepts, it falls to the instructors to design and sequence the learning experiences that will promote…

  5. High speed photodiodes in standard nanometer scale CMOS technology: a comparative study.

    Science.gov (United States)

    Nakhkoob, Behrooz; Ray, Sagar; Hella, Mona M

    2012-05-07

    This paper compares various techniques for improving the frequency response of silicon photodiodes fabricated in mainstream CMOS technology for fully integrated optical receivers. The three presented photodiodes, Spatially Modulated Light detectors, Double, and Interrupted P-Finger photodiodes, aim at reducing the low speed diffusive component of the photo generated current. For the first photodiode, Spatially Modulated Light (SML) detectors, the low speed current component is canceled out by converting it to a common mode current driving a differential transimpedance amplifier. The Double Photodiode (DP) uses two depletion regions to increase the fast drift component, while the Interrupted-P Finger Photodiode (IPFPD) redirects the low speed component towards a different contact from the main fast terminal of the photodiode. Extensive device simulations using 130 nm CMOS technology-parameters are presented to compare their performance using the same technological platform. Finally a new type of photodiode that uses triple well CMOS technology is introduced that can achieve a bandwidth of roughly 10 GHz without any process modification or high reverse bias voltages that would jeopardize the photodetector and subsequent transimpedance amplifier reliability.

  6. 77 FR 36485 - Alternative Personnel Management System (APMS) at the National Institute of Standards and Technology

    Science.gov (United States)

    2012-06-19

    ... also identify waiver language needed to retain the original system feature of an extended probationary... comments to Amy K. Cubert, Supervisory Human Resources Specialist, National Institute of Standards and... period, a feature of the original demonstration project and subsequent Alternative Personnel Management...

  7. Application of Stem Cell Technology in Dental Regenerative Medicine.

    Science.gov (United States)

    Feng, Ruoxue; Lengner, Chistopher

    2013-07-01

    In this review, we summarize the current literature regarding the isolation and characterization of dental tissue-derived stem cells and address the potential of these cell types for use in regenerative cell transplantation therapy. Looking forward, platforms for the delivery of stem cells via scaffolds and the use of growth factors and cytokines for enhancing dental stem cell self-renewal and differentiation are discussed. We aim to understand the developmental origins of dental tissues in an effort to elucidate the molecular pathways governing the genesis of somatic dental stem cells. The advantages and disadvantages of several dental stem cells are discussed, including the developmental stage and specific locations from which these cells can be purified. In particular, stem cells from human exfoliated deciduous teeth may act as a very practical and easily accessibly reservoir for autologous stem cells and hold the most value in stem cell therapy. Dental pulp stem cells and periodontal ligament stem cells should also be considered for their triple lineage differentiation ability and relative ease of isolation. Further, we address the potentials and limitations of induced pluripotent stem cells as a cell source in dental regenerative. From an economical and a practical standpoint, dental stem cell therapy would be most easily applied in the prevention of periodontal ligament detachment and bone atrophy, as well as in the regeneration of dentin-pulp complex. In contrast, cell-based tooth replacement due to decay or other oral pathology seems, at the current time, an untenable approach.

  8. Secondary Organic Aerosol Production from Gasoline Vehicle Exhaust: Effects of Engine Technology, Cold Start, and Emission Certification Standard.

    Science.gov (United States)

    Zhao, Yunliang; Lambe, Andrew T; Saleh, Rawad; Saliba, Georges; Robinson, Allen L

    2018-02-06

    Secondary organic aerosol (SOA) formation from dilute exhaust from 16 gasoline vehicles was investigated using a potential aerosol mass (PAM) oxidation flow reactor during chassis dynamometer testing using the cold-start unified cycle (UC). Ten vehicles were equipped with gasoline direct injection engines (GDI vehicles) and six with port fuel injection engines (PFI vehicles) certified to a wide range of emissions standards. We measured similar SOA production from GDI and PFI vehicles certified to the same emissions standard; less SOA production from vehicles certified to stricter emissions standards; and, after accounting for differences in gas-particle partitioning, similar effective SOA yields across different engine technologies and certification standards. Therefore the ongoing, dramatic shift from PFI to GDI vehicles in the United States should not alter the contribution of gasoline vehicles to ambient SOA and the natural replacement of older vehicles with newer ones certified to stricter emissions standards should reduce atmospheric SOA levels. Compared to hot operations, cold-start exhaust had lower effective SOA yields, but still contributed more SOA overall because of substantially higher organic gas emissions. We demonstrate that the PAM reactor can be used as a screening tool for vehicle SOA production by carefully accounting for the effects of the large variations in emission rates.

  9. Fiscal 1997 report on the results of the international standardization R and D. R and D of the standardization of a method to test acceleration life of phosphorous acid fuel cells; 1997 nendo seika hokokusho kokusai hyojun soseigata kenkyu kaihatsu. Rinsangata nenryo denchi no kasoku jumyo shiken hoho no hyojunka ni kansuru kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    As for fuel cells, which are expected as a new clean energy, the R and D are being proceeded with in various fields of the world, but the standardization has not been made both in Japan and abroad. In Japan, the situation is that the information on technical terms, indication method, performance test method, and environment/safety test methods of the phosphorous acid fuel cell power generation is publicly spread. In relation to the international promotion of fuel cells to be predicted, it is necessary to internationally standardize cells themselves which are a key component of fuel cell power generation facilities. Phosphorous acid fuel cells are expected of the earliest commercialization of all, but the common test method to evaluate life characteristics of the cell stack has not been established yet. In the R and D, for the purpose of internationally standardizing test methods to evaluate life characteristics of the cell stack, a study on the acceleration life test method of phosphoric acid fuel cells was conducted in terms of the technical trend, data, standard, etc. A plan was prepared on general rules of the method to test acceleration life at the cell reaction part of the small cell, and activities also were started for setting up a technical committee for the fuel cell power system in President`s Advisory Committee on Future Technology. 29 figs., 20 tabs.

  10. Review of Fuel Cell Technologies for Military Land Vehicles

    Science.gov (United States)

    2014-09-01

    2 3. FUELLING FUEL CELLS ...OEM Original Equipment Manufacturer PEM Proton Exchange Membrane PEMFC Proton Exchange Membrane Fuel Cell SOFC Solid Oxide Fuel Cell TRL Technical...UNCLASSIFIED DSTO-TN-1360 UNCLASSIFIED 4 3. Fuelling Fuel Cells 3.1 Hydrogen Hydrogen, either in its pure form or as reformate from another fuel is

  11. OneGeology Web Services and Portal as a global geological SDI - latest standards and technology

    Science.gov (United States)

    Duffy, Tim; Tellez-Arenas, Agnes

    2014-05-01

    The global coverage of OneGeology Web Services (www.onegeology.org and portal.onegeology.org) achieved since 2007 from the 120 participating geological surveys will be reviewed and issues arising discussed. Recent enhancements to the OneGeology Web Services capabilities will be covered including new up to 5 star service accreditation scheme utilising the ISO/OGC Web Mapping Service standard version 1.3, core ISO 19115 metadata additions and Version 2.0 Web Feature Services (WFS) serving the new IUGS-CGI GeoSciML V3.2 geological web data exchange language standard (http://www.geosciml.org/) with its associated 30+ IUGS-CGI available vocabularies (http://resource.geosciml.org/ and http://srvgeosciml.brgm.fr/eXist2010/brgm/client.html). Use of the CGI simpelithology and timescale dictionaries now allow those who wish to do so to offer data harmonisation to query their GeoSciML 3.2 based Web Feature Services and their GeoSciML_Portrayal V2.0.1 (http://www.geosciml.org/) Web Map Services in the OneGeology portal (http://portal.onegeology.org). Contributing to OneGeology involves offering to serve ideally 1:1000,000 scale geological data (in practice any scale now is warmly welcomed) as an OGC (Open Geospatial Consortium) standard based WMS (Web Mapping Service) service from an available WWW server. This may either be hosted within the Geological Survey or a neighbouring, regional or elsewhere institution that offers to serve that data for them i.e. offers to help technically by providing the web serving IT infrastructure as a 'buddy'. OneGeology is a standards focussed Spatial Data Infrastructure (SDI) and works to ensure that these standards work together and it is now possible for European Geological Surveys to register their INSPIRE web services within the OneGeology SDI (e.g. see http://www.geosciml.org/geosciml/3.2/documentation/cookbook/INSPIRE_GeoSciML_Cookbook%20_1.0.pdf). The Onegeology portal (http://portal.onegeology.org) is the first port of call for anyone

  12. Single-cell manipulation and DNA delivery technology using atomic force microscopy and nanoneedle.

    Science.gov (United States)

    Han, Sung-Woong; Nakamura, Chikashi; Miyake, Jun; Chang, Sang-Mok; Adachi, Taiji

    2014-01-01

    The recent single-cell manipulation technology using atomic force microscopy (AFM) not only allows high-resolution visualization and probing of biomolecules and cells but also provides spatial and temporal access to the interior of living cells via the nanoneedle technology. Here we review the development and application of single-cell manipulations and the DNA delivery technology using a nanoneedle. We briefly describe various DNA delivery methods and discuss their advantages and disadvantages. Fabrication of the nanoneedle, visualization of nanoneedle insertion into living cells, DNA modification on the nanoneedle surface, and the invasiveness of nanoneedle insertion into living cells are described. Different methods of DNA delivery into a living cell, such as lipofection, microinjection, and nanoneedles, are then compared. Finally, single-cell diagnostics using the nanoneedle and the perspectives of the nanoneedle technology are outlined. The nanoneedle-based DNA delivery technology provides new opportunities for efficient and specific introduction of DNA and other biomolecules into precious living cells with a high spatial resolution within a desired time frame. This technology has the potential to be applied for many basic cellular studies and for clinical studies such as single-cell diagnostics.

  13. Fabrication of advanced targets for laser driven nuclear fusion reactions through standard microelectronics technology approaches.

    Czech Academy of Sciences Publication Activity Database

    Picciotto, A.; Crivellari, M.; Bellutti, P.; Barozzi, M.; Kucharik, M.; Krása, Josef; Swidlovsky, A.; Malinowska, A.; Velyhan, Andriy; Ullschmied, Jiří; Margarone, Daniele

    2017-01-01

    Roč. 12, October (2017), č. článku P10001. ISSN 1748-0221 Grant - others:OP VK 2 LaserGen(XE) CZ.1.07/2.3.00/20.0087; LaserZdroj (OP VK 3)(XE) CZ.1.07/2.3.00/20.0279 Institutional support: RVO:61389021 ; RVO:68378271 Keywords : Nuclear instruments and methods for hot plasma diagnostics * Plasma generation (laserproduced, RF, x ray-produced) * Plasma diagnostics - charged-particle spectroscopy Subject RIV: BL - Plasma and Gas Discharge Physics; BL - Plasma and Gas Discharge Physics (FZU-D) OBOR OECD: 2.11 Other engineering and technologies; 2.11 Other engineering and technologies (FZU-D) Impact factor: 1.220, year: 2016 http://iopscience.iop.org/article/10.1088/1748-0221/12/10/P10001/meta

  14. NREL Topic 1 Final Report: Cohesive Application of Standards-Based Connected Devices to Enable Clean Energy Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Hudgins, Andrew P. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sparn, Bethany F. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jin, Xin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Seal, Brian [Electric Power Research Inst. (EPRI), Palo Alto, CA (United States)

    2018-02-21

    This document is the final report of a two-year development, test, and demonstration project entitled 'Cohesive Application of Standards-Based Connected Devices to Enable Clean Energy Technologies.' The project was part of the National Renewable Energy Laboratory's (NREL) Integrated Network Test-bed for Energy Grid Research and Technology (INTEGRATE) initiative. The Electric Power Research Institute (EPRI) and a team of partners were selected by NREL to carry out a project to develop and test how smart, connected consumer devices can act to enable the use of more clean energy technologies on the electric power grid. The project team includes a set of leading companies that produce key products in relation to achieving this vision: thermostats, water heaters, pool pumps, solar inverters, electric vehicle supply equipment, and battery storage systems. A key requirement of the project was open access at the device level - a feature seen as foundational to achieving a future of widespread distributed generation and storage. The internal intelligence, standard functionality and communication interfaces utilized in this project result in the ability to integrate devices at any level, to work collectively at the level of the home/business, microgrid, community, distribution circuit or other. Collectively, the set of products serve as a platform on which a wide range of control strategies may be developed and deployed.

  15. Standardized UXO Technology Demonstration Site Blind Grid Scoring Record No. 764

    Science.gov (United States)

    2006-04-01

    Attainable accuracy of depth (z) ± 0.3 meter Detection performance for ferrous and nonferrous metals : will detect ammunition components 20-mm...ASSOCIATES, INC. 6832 OLD DOMINION DRIVE MCLEAN, VA 22101 TECHNOLOGY TYPE/PLATFORM: MULTI CHANNEL DETECTOR SYSTEM (AMOS)/TOWED PREPARED BY: U.S...Multi Channel Detector System (AMOS)/Towed, MEC 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON a. REPORT Unclassified b. ABSTRACT

  16. Use and clinical efficacy of standard and health information technology fall risk assessment tools.

    Science.gov (United States)

    Teh, Ruth C; Wilson, Anne; Ranasinghe, Damith; Visvanathan, Renuka

    2017-12-01

    To evaluate the health information technology (HIT) compared to Fall Risk for Older Persons (FROP) tool in fall risk screening. A HIT tool trial was conducted on the geriatric evaluation and management (GEM, n = 111) and acute medical units (AMU, n = 424). Health information technology and FROP scores were higher on GEM versus AMU, with no differences between people who fell and people who did not fall. Both score completion rates were similar, and their values correlated marginally (Spearman's correlation coefficient 0.33, P falls. Hospital fall rates trended towards reduction on AMU (4.20 vs 6.96, P = 0.15) and increase on GEM (10.98 vs 6.52, P = 0.54) with HIT tool implementation. Health information technology tool acceptability and scoring were comparable to FROP screening, with mixed effects on fall rate with HIT tool implementation. Clinician partnership remains key to effective tool development. © 2017 AJA Inc.

  17. Medical Device Plug-and-Play Interoperability Standards and Technology Leadership

    Science.gov (United States)

    2016-10-01

    death,” The Boston Globe, April 3 2010. 27. Arney D, Pajic M, Goldman JM, Lee I, Mangharam R, Sokolsky O, “Toward Patient Safety in Closed - Loop Medical ...becoming increasingly clear. We have been providing medical device interoperability domain expertise to assist the Veterans Administration in a...15. Wallroth C, Goldman J, Manigel J, Osborn D, Roellike T, Weininger S, Westenskow D, “Development of a Standard for Physiologic Closed Loop

  18. Medical Device Plug-and-Play Interoperability Standards and Technology Leadership

    Science.gov (United States)

    2014-10-01

    Kaiser Permanente, Johns Hopkins Medicine, the VA, FDA, NIST, TATRC, computer and information science groups at University of Pennsylvania...for sharing the findings from our TATRC work and from our NIH Quantum work relative to the gaps in existing standards and recommendations on how they...challenges facing the industry in areas such as interoperability, cybersecurity , data stewardship, and system reliability, and policies needed to accelerate

  19. International Society for Analytical Cytology biosafety standard for sorting of unfixed cells.

    Science.gov (United States)

    Schmid, Ingrid; Lambert, Claude; Ambrozak, David; Marti, Gerald E; Moss, Delynn M; Perfetto, Stephen P

    2007-06-01

    Cell sorting of viable biological specimens has become very prevalent in laboratories involved in basic and clinical research. As these samples can contain infectious agents, precautions to protect instrument operators and the environment from hazards arising from the use of sorters are paramount. To this end the International Society of Analytical Cytology (ISAC) took a lead in establishing biosafety guidelines for sorting of unfixed cells (Schmid et al., Cytometry 1997;28:99-117). During the time period these recommendations have been available, they have become recognized worldwide as the standard practices and safety precautions for laboratories performing viable cell sorting experiments. However, the field of cytometry has progressed since 1997, and the document requires an update. Initially, suggestions about the document format and content were discussed among members of the ISAC Biosafety Committee and were incorporated into a draft version that was sent to all committee members for review. Comments were collected, carefully considered, and incorporated as appropriate into a draft document that was posted on the ISAC web site to invite comments from the flow cytometry community at large. The revised document was then submitted to ISAC Council for review. Simultaneously, further comments were sought from newly-appointed ISAC Biosafety committee members. This safety standard for performing viable cell sorting experiments was recently generated. The document contains background information on the biohazard potential of sorting and the hazard classification of infectious agents as well as recommendations on (1) sample handling, (2) operator training and personal protection, (3) laboratory design, (4) cell sorter set-up, maintenance, and decontamination, and (5) testing the instrument for the efficiency of aerosol containment. This standard constitutes an updated and expanded revision of the 1997 biosafety guideline document. It is intended to provide

  20. p-Type MWT. Integrated cell and module technology

    Energy Technology Data Exchange (ETDEWEB)

    Tool, C.J.J.; Kossen, E.J.; Bennett, I.J.

    2013-10-15

    A major issue of concern in MWT solar cells is the increased leakage current at reversed bias voltage through the vias compared. At ECN we have been working on reducing this leakage current to levels comparable to H-pattern cells. In this study we present the results of this work. We further show the benefit of a combined cell and module design for MWT solar cells. At the cell level, MWT production costs per wafer are comparable with H-pattern while the cell output increases. At the module level this design results in a further increase of the power output.

  1. p-type MWT. Integrated Cell and Module Technology

    Energy Technology Data Exchange (ETDEWEB)

    Tool, C.J.J.; Kossen, E.J.; Bennett, I.J. [ECN Solar Energy, Petten (Netherlands)

    2013-03-15

    A major issue of concern in MWT (metal wrap-through) solar cells is the increased leakage current at reversed bias voltage through the vias compared. At ECN we have been working on reducing this leakage current to levels comparable to H-pattern cells. In this study we present the results of this work. We further show the benefit of a combined cell and module design for MWT solar cells. At the cell level, MWT production costs per wafer are comparable with H-pattern while the cell output increases. At the module level this design results in a further increase of the power output.

  2. Evaluation of a standardized procedure for [corrected] microscopic cell counts [corrected] in body fluids.

    Science.gov (United States)

    Emerson, Jane F; Emerson, Scott S

    2005-01-01

    A standardized urinalysis and manual microscopic cell counting system was evaluated for its potential to reduce intra- and interoperator variability in urine and cerebrospinal fluid (CSF) cell counts. Replicate aliquots of pooled specimens were submitted blindly to technologists who were instructed to use either the Kova system with the disposable Glasstic slide (Hycor Biomedical, Inc., Garden Grove, CA) or the standard operating procedure of the University of California-Irvine (UCI), which uses plain glass slides for urine sediments and hemacytometers for CSF. The Hycor system provides a mechanical means of obtaining a fixed volume of fluid in which to resuspend the sediment, and fixes the volume of specimen to be microscopically examined by using capillary filling of a chamber containing in-plane counting grids. Ninety aliquots of pooled specimens of each type of body fluid were used to assess the inter- and intraoperator reproducibility of the measurements. The variability of replicate Hycor measurements made on a single specimen by the same or different observers was compared with that predicted by a Poisson distribution. The Hycor methods generally resulted in test statistics that were slightly lower than those obtained with the laboratory standard methods, indicating a trend toward decreasing the effects of various sources of variability. For 15 paired aliquots of each body fluid, tests for systematically higher or lower measurements with the Hycor methods were performed using the Wilcoxon signed-rank test. Also examined was the average difference between the Hycor and current laboratory standard measurements, along with a 95% confidence interval (CI) for the true average difference. Without increasing labor or the requirement for attention to detail, the Hycor method provides slightly better interrater comparisons than the current method used at UCI. Copyright 2005 Wiley-Liss, Inc.

  3. Restructuring an EHR system and the Medical Markup Language (MML) standard to improve interoperability by archetype technology.

    Science.gov (United States)

    Kobayashi, Shinji; Kume, Naoto; Yoshihara, Hiroyuki

    2015-01-01

    In 2001, we developed an EHR system for regional healthcare information inter-exchange and to provide individual patient data to patients. This system was adopted in three regions in Japan. We also developed a Medical Markup Language (MML) standard for inter- and intra-hospital communications. The system was built on a legacy platform, however, and had not been appropriately maintained or updated to meet clinical requirements. To improve future maintenance costs, we reconstructed the EHR system using archetype technology on the Ruby on Rails platform, and generated MML equivalent forms from archetypes. The system was deployed as a cloud-based system for preliminary use as a regional EHR. The system now has the capability to catch up with new requirements, maintaining semantic interoperability with archetype technology. It is also more flexible than the legacy EHR system.

  4. The Effective Use of System and Software Architecture Standards for Software Technology Readiness Assessments

    Science.gov (United States)

    2011-05-01

    icons, mouse- control and network paradigms. Successfully directed engineering and quality process development on all levels of the enterprise. As...Actual system proven through successful mission operations A t l t l t d d lifi d th h t t d TRL 9 TRL 8 c ua sys em comp e e an qua e roug es an...A Software Technology Example • Net Centricity – a typical, new mission requirement – Network Centric Warfare (NCW) • NCW is a state-of-the art war

  5. The method of using current regulations and standards in designing management and technologies of construction

    Directory of Open Access Journals (Sweden)

    Sinenko Sergey

    2017-01-01

    Full Text Available Economic efficiency of using funds in construction of buildings and structures begins from an effective, proper design, which is based on modern, cutting-edge, advanced equipment, streamlined organization and process solutions of construction operations. In the light of this it is considered application of “Self-Organization and Technology of Building” multifunctional software package capable of solving various engineering tasks on designing management of construction operations in accordance with the applicable rules and regulations in view of using software for automatic generation of workflow. Implementing this software in the construction management processes may help to solve management tasks at the construction site.

  6. Technical Standards for Command and Control Information Systems (CCISs) and Information Technology

    Science.gov (United States)

    1994-02-01

    7.2.2.3 Computer Graphics Interface (CGI) ISO and ANSI have drafted the CGI standard, formerly the Computer Graphics Virtual Device Interface (CG- VDI ), to...provided a bit stream service (64- 2048 kbit/s) without any special protocol enhancements. The choice of protocol, protocol options, and variables is...with VDI Virtual Device bh oe Big Ad•rm VDM-SL Viemia Development Method-Specificuk 7WG Technical Workog Group Language 7x XA•pen Transport Interface

  7. How to develop a Standard Operating Procedure for sorting unfixed cells

    Science.gov (United States)

    Schmid, Ingrid

    2012-01-01

    Written Standard Operating Procedures (SOPs) are an important tool to assure that recurring tasks in a laboratory are performed in a consistent manner. When the procedure covered in the SOP involves a high-risk activity such as sorting unfixed cells using a jet-in-air sorter, safety elements are critical components of the document. The details on sort sample handling, sorter set-up, validation, operation, troubleshooting, and maintenance, personal protective equipment (PPE), and operator training, outlined in the SOP are to be based on careful risk assessment of the procedure. This review provides background information on the hazards associated with sorting of unfixed cells and the process used to arrive at the appropriate combination of facility design, instrument placement, safety equipment, and practices to be followed. PMID:22381383

  8. How to develop a standard operating procedure for sorting unfixed cells.

    Science.gov (United States)

    Schmid, Ingrid

    2012-07-01

    Written standard operating procedures (SOPs) are an important tool to assure that recurring tasks in a laboratory are performed in a consistent manner. When the procedure covered in the SOP involves a high-risk activity such as sorting unfixed cells using a jet-in-air sorter, safety elements are critical components of the document. The details on sort sample handling, sorter set-up, validation, operation, troubleshooting, and maintenance, personal protective equipment (PPE), and operator training, outlined in the SOP are to be based on careful risk assessment of the procedure. This review provides background information on the hazards associated with sorting of unfixed cells and the process used to arrive at the appropriate combination of facility design, instrument placement, safety equipment, and practices to be followed. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Novel Technology for Cloning Prostate Cancer Cell Markers

    National Research Council Canada - National Science Library

    Bancroft, F

    2002-01-01

    The purpose of the project is to employ probes isolated from the LNCaP series of human prostate cancer cells, to probe human cDNA microarrays, so as to investigate genes differentially expressed among these cell lines...

  10. 2010 Fuel Cell Technologies Market Report, June 2011

    Energy Technology Data Exchange (ETDEWEB)

    2011-06-01

    This report summarizes 2010 data on fuel cells, including market penetration and industry trends. It also covers cost, price, and performance trends, along with policy and market drivers and the future outlook for fuel cells.

  11. Transportable GPU (General Processor Units) chip set technology for standard computer architectures

    Science.gov (United States)

    Fosdick, R. E.; Denison, H. C.

    1982-11-01

    The USAFR-developed GPU Chip Set has been utilized by Tracor to implement both USAF and Navy Standard 16-Bit Airborne Computer Architectures. Both configurations are currently being delivered into DOD full-scale development programs. Leadless Hermetic Chip Carrier packaging has facilitated implementation of both architectures on single 41/2 x 5 substrates. The CMOS and CMOS/SOS implementations of the GPU Chip Set have allowed both CPU implementations to use less than 3 watts of power each. Recent efforts by Tracor for USAF have included the definition of a next-generation GPU Chip Set that will retain the application-proven architecture of the current chip set while offering the added cost advantages of transportability across ISO-CMOS and CMOS/SOS processes and across numerous semiconductor manufacturers using a newly-defined set of common design rules. The Enhanced GPU Chip Set will increase speed by an approximate factor of 3 while significantly reducing chip counts and costs of standard CPU implementations.

  12. Test and Approval Center for Fuel Cell and Hydrogen Technologies: Phase I. Initiation

    DEFF Research Database (Denmark)

    already spent on these technologies also lead to commercial success. The project ‘Test and Approval Center for Fuel Cell and Hydrogen Technologies: Phase I. Initiation’ was aiming at starting with the Establishment of such a center. The following report documents the achievements within the project...... of the fluctuating wind energy. As the fuel cell and hydrogen technologies come closer to commercialization, development of testing methodology, qualified testing and demonstration become increasingly important. Danish industrial players have expressed a strong need for support in the process to push fuel cell...... and hydrogen technologies from the research and development stage into the commercial domain. A Center to support industry with test, development, analysis, approval, certification, consultation, and training in the areas of fuel cell and hydrogen technologies was needed. Denmark has demonstrated leading...

  13. Bilateral Comparison of Mercury and Gallium Fixed-Point Cells Using Standard Platinum Resistance Thermometer

    Science.gov (United States)

    Bojkovski, J.; Veliki, T.; Zvizdić, D.; Drnovšek, J.

    2011-08-01

    The objective of project EURAMET 1127 (Bilateral comparison of triple point of mercury and melting point of gallium) in the field of thermometry is to compare realization of a triple point of mercury (-38.8344 °C) and melting point of gallium (29.7646 °C) between the Slovenian national laboratory MIRS/UL-FE/LMK and the Croatian national laboratory HMI/FSB-LPM using a long-stem 25 Ω standard platinum resistance thermometer (SPRT). MIRS/UL/FE-LMK participated in a number of intercomparisons on the level of EURAMET. On the other hand, the HMI/LPM-FSB laboratory recently acquired new fixed-point cells which had to be evaluated in the process of intercomparisons. A quartz-sheathed SPRT has been selected and calibrated at HMI/LPM-FSB at the triple point of mercury, the melting point of gallium, and the water triple point. A second set of measurements was made at MIRS/UL/FE-LMK. After its return, the SPRT was again recalibrated at HMI/LPM-FSB. In the comparison, the W value of the SPRT has been used. Results of the bilateral intercomparison confirmed that the new gallium cell of the HMI/LPM-FSB has a value that is within uncertainty limits of both laboratories that participated in the exercise, while the mercury cell experienced problems. After further research, a small leakage in the mercury fixed-point cell has been found.

  14. Analysis of multiple types of human cells subsequent to bioprinting with electrospraying technology.

    Science.gov (United States)

    Xin, Yu; Chai, Gang; Zhang, Ting; Wang, Xiangsheng; Qu, Miao; Tan, Andy; Bogari, Melia; Zhu, Ming; Lin, Li; Hu, Qingxi; Liu, Yuanyuan; Zhang, Yan

    2016-12-01

    The aim of the present study was to investigate bioprinting with electrospraying technology using multiple types of human cell suspensions as bio-ink, in order to lay the initial foundations for the application of the bioprinting technology in tissue engineering. In the current study, six types of human cells were selected and cultured, including human fibroblasts, human adipose-derived stem cells (hADSCs), human periodontal ligament cells (HPDLCs), adult human retinal pigment epithelial cells (ARPE-19), human umbilical vascular endothelial cells (HUVECs) and human gastric epithelial cell line (GES-1). Each cell type was divided into two groups, the experimental and control group. All the experimental group cells were electrosprayed using an electrospraying printer (voltage, 15 kV; flow rate, 150 µl/min) and collected in a petri dish placed 15 cm away from the needle (needle diameter, 0.5 mm). Subsequently, cell viability was detected by flow cytometry with a Live/Dead Viability kit. In addition, the cell morphological characteristics were observed with a phase-contrast microscope after 6 h of culturing in order to obtain adherent cells, while cell proliferation was analyzed using a Cell Counting Kit-8 assay. The control groups, without printing, were subjected to the same procedures as the experimental groups. The results of the cell viability and proliferation assays indicated a statistically significant difference after printing between the experiments and control groups only for the hADSCs (P0.05). In addition, there were no observable differences between all experimental and the control groups at any examined time point in the terms of cell morphological characteristics. In conclusion, bioprinting based on electrospraying technology demonstrated no distinct negative effect on cell vitality, proliferation and morphology in the present study, and thus the application of this novel technology to cell printing may provide a promising method in tissue engineering.

  15. Development of Inorganic Solar Cells by Nano-technology

    Institute of Scientific and Technical Information of China (English)

    Yafei Zhang; HueyLiang Hwang; Huijuan Geng; Zhihua Zhou; Jiang Wu; Zhiming Wang; Yaozhong Zhang; Zhongli Li; Liying Zhang; Zhi Yang

    2012-01-01

    Inorganic solar cells, as durable photovoltaic devices for harvesting electric energy from sun light, have received tremendous attention due to the fear of exhausting the earth’s energy resources and damaging the living environment due to greenhouse gases. Some recent developments in nanotechnology have opened up new avenues for more relevant inorganic solar cells produced by new photovoltaic conversion concepts and effective solar energy harvesting nanostructures. In this review, the multiple exciton generation effect solar cells, hot carrier solar cells, one dimensional material constructed asymmetrical schottky barrier arrays, noble nanoparticle induced plasmonic enhancement, and light trapping nanostructured semiconductor solar cells are highlighted.

  16. A review of performance standards to monitor, evaluate and assess the impact of technology transfer offices

    Directory of Open Access Journals (Sweden)

    Sibongile Gumbi

    2010-07-01

    Full Text Available The conversion of scientific discoveries to new products and processes and their launch onto the market can be a lengthy process. Similarly, it takes many years before the impact of scientific research on society and the economy is realised and a further length of time before its performance can be measured. Higher education and research institutions, and their governments, often make significant investments into intellectual property management and technology transfer activities through legislative and policy development, human resource development, financial allocation and infrastructure improvement. Since returns on such investments are not immediately apparent, it is important to establish a means by which the impact of their efforts can be determined. In this paper, I examined the measures and indicators that could be developed by institutions and their stakeholders in order to monitor, evaluate and determine the impact of research output and outcomes on the market.

  17. Transformation of standardized clinical models based on OWL technologies: from CEM to OpenEHR archetypes.

    Science.gov (United States)

    Legaz-García, María del Carmen; Menárguez-Tortosa, Marcos; Fernández-Breis, Jesualdo Tomás; Chute, Christopher G; Tao, Cui

    2015-05-01

    The semantic interoperability of electronic healthcare records (EHRs) systems is a major challenge in the medical informatics area. International initiatives pursue the use of semantically interoperable clinical models, and ontologies have frequently been used in semantic interoperability efforts. The objective of this paper is to propose a generic, ontology-based, flexible approach for supporting the automatic transformation of clinical models, which is illustrated for the transformation of Clinical Element Models (CEMs) into openEHR archetypes. Our transformation method exploits the fact that the information models of the most relevant EHR specifications are available in the Web Ontology Language (OWL). The transformation approach is based on defining mappings between those ontological structures. We propose a way in which CEM entities can be transformed into openEHR by using transformation templates and OWL as common representation formalism. The transformation architecture exploits the reasoning and inferencing capabilities of OWL technologies. We have devised a generic, flexible approach for the transformation of clinical models, implemented for the unidirectional transformation from CEM to openEHR, a series of reusable transformation templates, a proof-of-concept implementation, and a set of openEHR archetypes that validate the methodological approach. We have been able to transform CEM into archetypes in an automatic, flexible, reusable transformation approach that could be extended to other clinical model specifications. We exploit the potential of OWL technologies for supporting the transformation process. We believe that our approach could be useful for international efforts in the area of semantic interoperability of EHR systems. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. [Research and implementation of the TLS network transport security technology based on DICOM standard].

    Science.gov (United States)

    Lu, Xiaoqi; Wang, Lei; Zhao, Jianfeng

    2012-02-01

    With the development of medical information, Picture Archiving and Communications System (PACS), Hospital Information System/Radiology Information System(HIS/RIS) and other medical information management system become popular and developed, and interoperability between these systems becomes more frequent. So, these enclosed systems will be open and regionalized by means of network, and this is inevitable. If the trend becomes true, the security of information transmission may be the first problem to be solved. Based on the need for network security, we investigated the Digital Imaging and Communications in Medicine (DICOM) Standard and Transport Layer Security (TLS) Protocol, and implemented the TLS transmission of the DICOM medical information with OpenSSL toolkit and DCMTK toolkit.

  19. Recent technological updates and clinical applications of induced pluripotent stem cells.

    Science.gov (United States)

    Diecke, Sebastian; Jung, Seung Min; Lee, Jaecheol; Ju, Ji Hyeon

    2014-09-01

    Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged as a promising cell source for clinical applications. The rapid progression in iPSC technology is still ongoing and directed toward increasing the efficacy of iPSC production and reducing the immunogenic and tumorigenic potential of these cells. Enormous efforts have been made to apply iPSC-based technology in the clinic, for drug screening approaches and cell replacement therapy. Moreover, disease modeling using patient-specific iPSCs continues to expand our knowledge regarding the pathophysiology and prospective treatment of rare disorders. Furthermore, autologous stem cell therapy with patient-specific iPSCs shows great propensity for the minimization of immune reactions and the provision of a limitless supply of cells for transplantation. In this review, we discuss the recent updates in iPSC technology and the use of iPSCs in disease modeling and regenerative medicine.

  20. Vehicle Technologies and Fuel Cell Technologies Office Research and Development Programs: Prospective Benefits Assessment Report for Fiscal Year 2018

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, T. S. [Argonne National Lab. (ANL), Argonne, IL (United States); Birky, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Gohlke, David [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-11-01

    Under a diverse set of programs, the Vehicle Technologies and Fuel Cell Technologies Offices of the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy invest in early-stage research of advanced batteries and electrification, engines and fuels, materials, and energy-efficient mobility systems; hydrogen production, delivery, and storage; and fuel cell technologies. This report documents the estimated benefits of successful development and implementation of advanced vehicle technologies. It presents a comparison of a scenario with completely successful implementation of Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) technologies (the Program Success case) to a future in which there is no contribution after Fiscal Year 2017 by the VTO or FCTO to these technologies (the No Program case). Benefits were attributed to individual program technology areas, which included FCTO research and development and the VTO programs of electrification, advanced combustion engines and fuels, and materials technology. Projections for the Program Success case indicate that by 2035, the average fuel economy of on-road, light-duty vehicle stock could be 24% to 30% higher than in the No Program case, while fuel economy for on-road medium- and heavy-duty vehicle stock could be as much as 13% higher. The resulting petroleum savings in 2035 were estimated to be as high as 1.9 million barrels of oil per day, and reductions in greenhouse gas emissions were estimated to be as high as 320 million metric tons of carbon dioxide equivalent per year. Projections of light-duty vehicle adoption indicate that although advanced-technology vehicles may be somewhat more expensive to purchase, the fuel savings result in a net reduction of consumer cost. In 2035, reductions in annual fuel expenditures for vehicles (both light- and heavy-duty) are projected to range from $86 billion to $109 billion (2015$), while the projected increase in new vehicle

  1. Standards for the culture and quality control of umbilical cord mesenchymal stromal cells for neurorestorative clinical application (2017

    Directory of Open Access Journals (Sweden)

    Ao Q

    2017-12-01

    Full Text Available Qiang Ao,1,* Juan Xiao,2,3,* Yanqiu Yu,4 Gengsheng Mao,2 Qingyan Zou,5 Wenyong Gao,2,3 Hongyun Huang2,3 On behalf of Neurorestoratology Professional Committee of Chinese Medical Doctor Association (Chinese Association of Neurorestoratology 1Department of Tissue Engineering, China Medical University, Shen Yang, 2Institute of Neurorestoratology, General Hospital of Armed Police Forces, Beijing, 3Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Beijing, 4Department of Pathophysiology, China Medical University, Shen Yang, 5Guangdong 999 Brain Hospital, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Formulating common standards for the culture and quality control of umbilical cord mesenchymal stromal cells (MSCs is crucial for the standardization of clinical neurorestorative therapy. But to date, there have been no standardized guidelines for the culture and quality control of MSCs in neurorestorative clinical application. Based on a relatively comprehensive review of published clinical studies as well as the existing methods of MSC culture and quality control, the Chinese Association of Neurorestoratology has developed standards for the culture and quality control of umbilical cord MSCs which possess the potential in neurorestorative clinical application. These guidelines include standardized training and management procedures for laboratory operators; standardized use and management of materials and equipment; standardized collection, culture and proliferation of umbilical cord MSCs; standardized management for cell preservation, transport and related safeguard measures; as well as standardization of a clean environment, routine maintenance and related tests and examinations and so on. These guidelines represent the minimum required standards for the culture and quality control of umbilical cord MSCs for potential use in current neurorestorative clinical therapy, and will be further

  2. The benefits of integrating Internet technology with standard communications for telemedicine in extreme environments.

    Science.gov (United States)

    Harnett, B M; Satava, R; Angood, P; Merriam, N R; Doarn, C R; Merrell, R C

    2001-12-01

    The ability to continuously monitor the vital signs of a person can be beneficial especially if the environment is hazardous or a person simply has general health concerns. We wanted to ascertain if, by integrating the Internet, ubiquitous switching technologies and off-the-shelf tools, this "suite of services" could provide a topology to enable remote monitoring in extreme and remote locations. An evaluation of this approach was conducted at the base camp of Mount Everest in the spring of 1999. Three climbers were outfitted with wireless, wearable sensors and transmitters for 24 h as they ascended through the Khumbu Icefall toward Camp One. The physiologic data was forwarded to the receiving station at Base Camp where it was forwarded to the U.S. mainland. Two of the three devices delivered physiologic data 95%-100% of the time while the third unit operated at only 78%. According to the climbers, the devices were unobtrusive, however, any additional weight while climbing Everest must provide advantage.

  3. Implementing new technologies for public safety communication: competing frequency demands and standardization issues

    Science.gov (United States)

    Stevens, Kathryn J.

    1997-01-01

    Attempting to incorporate new technology into an existing environment is often very difficult. The problems are lengthy to resolve, wrought with confusion and seldom turn out like anyone expected. This document represents an overview of one such attempt. It outlines the general areas of concern which could be affected by a transition, and potential problems that may be encountered as a result of the effort. Over the past several decades, many local, state and federal agencies are pressing for more efficient use of frequency spectrums. The urgency of this issue has grown due to the demands of several groups wanting access to these channels for commercial use. Pager systems, cellular telephones, radio systems for private businesses all demand more space. Public safety agencies are starting to fear their needs will diminish in importance as the available channel spectrums are consumed by commercial ventures. How to share these channels, purchase appropriate equipment to meet your needs, and stay within a reasonable budget are not easy tasks. Public safety agencies who rely on communication networks in the performance of their jobs also know why encryption is important. Protecting the rights of citizens as police exchange information over the air, maintaining the integrity of an investigation and officer safety are all concerns police must address each time they use a radio.

  4. Assessing the accuracy of forecasting: applying standard diagnostic assessment tools to a health technology early warning system.

    Science.gov (United States)

    Simpson, Sue; Hyde, Chris; Cook, Alison; Packer, Claire; Stevens, Andrew

    2004-01-01

    Early warning systems are an integral part of many health technology assessment programs. Despite this finding, to date, there have been no quantitative evaluations of the accuracy of predictions made by these systems. We report a study evaluating the accuracy of predictions made by the main United Kingdom early warning system. As prediction of impact is analogous to diagnosis, a method normally applied to determine the accuracy of diagnostic tests was used. The sensitivity, specificity, and predictive values of the National Horizon Scanning Centre's prediction methods were estimated with reference to an (imperfect) gold standard, that is, expert opinion of impact 3 to 5 years after prediction. The sensitivity of predictions was 71 percent (95 percent confidence interval [CI], 0.36-0.92), and the specificity was 73 percent (95 percent CI, 0.64-0.8). The negative predictive value was 98 percent (95 percent CI, 0.92-0.99), and the positive predictive value was 14 percent (95 percent CI, 0.06-0.3). Forecasting is difficult, but the results suggest that this early warning system's predictions have an acceptable level of accuracy. However, there are caveats. The first is that early warning systems may themselves reduce the impact of a technology, as helping to control adoption and diffusion is their main purpose. The second is that the use of an imperfect gold standard may bias the results. As early warning systems are viewed as an increasingly important component of health technology assessment and decision making, their outcomes must be evaluated. The method used here should be investigated further and the accuracy of other early warning systems explored.

  5. The 3rd ATLAS Domestic Standard Problem for Improvement of Safety Analysis Technology

    International Nuclear Information System (INIS)

    Choi, Ki-Yong; Kang, Kyoung-Ho; Park, Yusun; Kim, Jongrok; Bae, Byoung-Uhn; Choi, Nam-Hyun

    2014-01-01

    The third ATLAS DSP (domestic standard problem exercise) was launched at the end of 2012 in response to the strong need for continuation of the ATLAS DSP. A guillotine break of a main steam line without LOOP at a zero power condition was selected as a target scenario, and it was successfully completed in the beginning of 2014. In the 3 rd ATLAS DSP, comprehensive utilization of the integral effect test data was made by dividing analysis with three topics; 1. scale-up where extrapolation of ATLAS IET data was investigated 2. 3D analysis where how much improvement can be obtained by 3D modeling was studied 3. 1D sensitivity analysis where the key phenomena affecting the SLB simulation were identified and the best modeling guideline was achieved. Through such DSP exercises, it has been possible to effectively utilize high-quality ATLAS experimental data of to enhance thermal-hydraulic understanding and to validate the safety analysis codes. A strong human network and technical expertise sharing among the various nuclear experts are also important outcomes from this program

  6. Technology development for evaluation of operational quantities and measurement standard in radiation protection

    International Nuclear Information System (INIS)

    Chang, Si Young; Lee, T. Y.; Kim, J. L.; Kim, B. H.; Chung, K. K.; Lee, J. I.; Park, T. S.; Ha, S. H.; Oh, P. J.; Jun, K. J.

    1999-03-01

    A study on the fabrication of a new personal thermo-luminescence dosimeter, which can evaluate the personal dose equivalent H p (d), has been performed. Optimum conditions for fabrications of a LiF:Mg, Cu, Na, Si TL phosphor powder has been determined and a disc type TL pellet has been fabricated from this TL powder. Another type of CaSO 4 :Dy, Mo TL material has been also fabricated. These two TL materials have shown greater TL sensitivity than the foreign-made commercial TL materials. Mono-energetic florescence X-rays from 8.6 response have been constructed and evaluated for the performance of the purity, air kerma, beam uniformity and distribution,and scattered fraction of X-rays. A free-air ionization chamber for the absolute measurement of air kerma in medium X-ray has been designed and constructed. Experimental results showed that the homemade chamber leaves nothing to be desired, compared with the national standard chambers in other advanced countries. Gas proportional counting system has been designed and constructed for absolute activity measurements of gaseous radionuclides. Unattached fractions of radon progeny were evaluated in the characteristic study on the detection of radon progeny

  7. Technology development for evaluation of operational quantities and measurement standard in radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Si Young; Lee, T. Y.; Kim, J. L.; Kim, B. H.; Chung, K. K.; Lee, J. I.; Park, T. S.; Ha, S. H.; Oh, P. J.; Jun, K. J

    1999-03-01

    A study on the fabrication of a new personal thermo-luminescence dosimeter, which can evaluate the personal dose equivalent H{sub p}(d), has been performed. Optimum conditions for fabrications of a LiF:Mg, Cu, Na, Si TL phosphor powder has been determined and a disc type TL pellet has been fabricated from this TL powder. Another type of CaSO{sub 4}:Dy, Mo TL material has been also fabricated. These two TL materials have shown greater TL sensitivity than the foreign-made commercial TL materials. Mono-energetic florescence X-rays from 8.6 response have been constructed and evaluated for the performance of the purity, air kerma, beam uniformity and distribution,and scattered fraction of X-rays.A free-air ionization chamber for the absolute measurement of air kerma in medium X-ray has been designed and constructed. Experimental results showed that the homemade chamber leaves nothing to be desired, compared with the national standard chambers in other advanced countries. Gas proportional counting system has been designed and constructed for absolute activity measurements of gaseous radionuclides. Unattached fractions of radon progeny were evaluated in the characteristic study on the detection of radon progeny.

  8. Status of molten carbonate fuel cell technology development

    Science.gov (United States)

    Parsons, E. L., Jr.; Williams, M. C.; George, T. J.

    The MCFC technology has been identified by the DOE as a promising product for commercialization. Development of the MCFC technology supports the National Energy Strategy. Review of the status of the MCFC technology indicates that the MCFC technology developers are making rapid and significant progress. Manufacturing facility development and extensive testing is occurring. Improvements in performance (power density), lower costs, improved packaging, and scale up to full height are planned. MCFC developers need to continue to be responsive to end-users in potential markets. It will be market demands for the correct product definition which will ultimately determine the character of MCFC power plants. There is a need for continued MCFC product improvement and multiple product development tests.

  9. Impact of New Camera Technologies on Discoveries in Cell Biology.

    Science.gov (United States)

    Stuurman, Nico; Vale, Ronald D

    2016-08-01

    New technologies can make previously invisible phenomena visible. Nowhere is this more obvious than in the field of light microscopy. Beginning with the observation of "animalcules" by Antonie van Leeuwenhoek, when he figured out how to achieve high magnification by shaping lenses, microscopy has advanced to this day by a continued march of discoveries driven by technical innovations. Recent advances in single-molecule-based technologies have achieved unprecedented resolution, and were the basis of the Nobel prize in Chemistry in 2014. In this article, we focus on developments in camera technologies and associated image processing that have been a major driver of technical innovations in light microscopy. We describe five types of developments in camera technology: video-based analog contrast enhancement, charge-coupled devices (CCDs), intensified sensors, electron multiplying gain, and scientific complementary metal-oxide-semiconductor cameras, which, together, have had major impacts in light microscopy. © 2016 Marine Biological Laboratory.

  10. Advanced cell culture technology for generation of in vivo-like tissue models

    OpenAIRE

    Przyborski, Stefan

    2017-01-01

    Human tissues are mostly composed of different cell types, that are often highly organised in relation to each other. Often cells are arranged in distinct layers that enable signalling and cell-to-cell interactions. Here we describe the application of scaffold-based technology, that can be used to create advanced organotypic 3D models of various tissue types that more closely resemble in vivo-like conditions (Knight et al., 2011). The scaffold comprises a highly porous polystyrene material, e...

  11. Prognostic value of tumor-to-blood standardized uptake ratio in patients with resectable non-small-cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Seung Hyeon; Pak, Kyoung June; Kim, In Joo [Dept. of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan(Korea, Republic of); Kim, Bum Soo; Kim, Seong Jang [Dept. of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan (Korea, Republic of)

    2017-09-15

    Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUVmax). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery.

  12. Prognostic value of tumor-to-blood standardized uptake ratio in patients with resectable non-small-cell lung cancer

    International Nuclear Information System (INIS)

    Shin, Seung Hyeon; Pak, Kyoung June; Kim, In Joo; Kim, Bum Soo; Kim, Seong Jang

    2017-01-01

    Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUVmax). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery

  13. Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards.

    Science.gov (United States)

    Jiang, Guoqian; Evans, Julie; Endle, Cory M; Solbrig, Harold R; Chute, Christopher G

    2016-01-01

    The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development. We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates. A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6). Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.

  14. Cell-printing and transfer technology applications for bone defects in mice.

    Science.gov (United States)

    Tsugawa, Junichi; Komaki, Motohiro; Yoshida, Tomoko; Nakahama, Ken-ichi; Amagasa, Teruo; Morita, Ikuo

    2011-10-01

    Bone regeneration therapy based on the delivery of osteogenic factors and/or cells has received a lot of attention in recent years since the discovery of pluripotent stem cells. We reported previously that the implantation of capillary networks engineered ex vivo by the use of cell-printing technology could improve blood perfusion. Here, we developed a new substrate prepared by coating glass with polyethylene glycol (PEG) to create a non-adhesive surface and subsequent photo-lithography to finely tune the adhesive property for efficient cell transfer. We examined the cell-transfer efficiency onto amniotic membrane and bone regenerative efficiency in murine calvarial bone defect. Cell transfer of KUSA-A1 cells (murine osteoblasts) to amniotic membrane was performed for 1 h using the substrates. Cell transfer using the substrate facilitated cell engraftment onto the amniotic membrane compared to that by direct cell inoculation. KUSA-A1 cells transferred onto the amniotic membrane were applied to critical-sized calvarial bone defects in mice. Micro-computed tomography (micro-CT) analysis showed rapid and effective bone formation by the cell-equipped amniotic membrane. These results indicate that the cell-printing and transfer technology used to create the cell-equipped amniotic membrane was beneficial for the cell delivery system. Our findings support the development of a biologically stable and effective bone regeneration therapy. Copyright © 2011 John Wiley & Sons, Ltd.

  15. Perspectives for induced pluripotent stem cell technology: new insights into human physiology involved in somatic mosaicism.

    Science.gov (United States)

    Nagata, Naoki; Yamanaka, Shinya

    2014-01-31

    Induced pluripotent stem cell technology makes in vitro reprogramming of somatic cells from individuals with various genetic backgrounds possible. By applying this technology, it is possible to produce pluripotent stem cells from biopsy samples of arbitrarily selected individuals with various genetic backgrounds and to subsequently maintain, expand, and stock these cells. From these induced pluripotent stem cells, target cells and tissues can be generated after certain differentiation processes. These target cells/tissues are expected to be useful in regenerative medicine, disease modeling, drug screening, toxicology testing, and proof-of-concept studies in drug development. Therefore, the number of publications concerning induced pluripotent stem cells has recently been increasing rapidly, demonstrating that this technology has begun to infiltrate many aspects of stem cell biology and medical applications. In this review, we discuss the perspectives of induced pluripotent stem cell technology for modeling human diseases. In particular, we focus on the cloning event occurring through the reprogramming process and its ability to let us analyze the development of complex disease-harboring somatic mosaicism.

  16. Stem Cell Tracking Technologies for Neurological Regenerative Medicine Purposes

    Directory of Open Access Journals (Sweden)

    Yongtao Zheng

    2017-01-01

    Full Text Available The growing field of stem cell therapy is moving toward clinical trials in a variety of applications, particularly for neurological diseases. However, this translation of cell therapies into humans has prompted a need to create innovative and breakthrough methods for stem cell tracing, to explore the migration routes and its reciprocity with microenvironment targets in the body, to monitor and track the outcome after stem cell transplantation therapy, and to track the distribution and cell viability of transplanted cells noninvasively and longitudinally. Recently, a larger number of cell tracking methods in vivo were developed and applied in animals and humans, including magnetic resonance imaging, nuclear medicine imaging, and optical imaging. This review has been intended to summarize the current use of those imaging tools in tracking stem cells, detailing their main features and drawbacks, including image resolution, tissue penetrating depth, and biosafety aspects. Finally, we address that multimodality imaging method will be a more potential tracking tool in the future clinical application.

  17. Phenothiazine-Based Dyes in Solar Cell Technology

    Directory of Open Access Journals (Sweden)

    Andrei Bejan

    2017-12-01

    Full Text Available Phenothiazine is a fused heterocyclic ring with strong electron-donating character which makes it an important building block for designing organic materials for solar cells applications. The present paper reviews the most recent achievements of phenothiazine-based compounds as dyes in solar cells, with special emphasis on the structure – performance relationship.

  18. Maintenance of electrolytic cells with failure technologic mode

    International Nuclear Information System (INIS)

    Galushkin, N.V.

    1995-01-01

    This chapter of monograph is devoted to failures in regular operation of electrolytic cell and ways of their neutralization. Thus, the main failures in regular operation of electrolytic cell, including hot driving, cold driving of tank, carbides formation were studied. The emergency cases in operation of tanks and ways of their neutralization were described.

  19. Solar Cell and Array Technology Development for NASA Solar Electric Propulsion Missions

    Science.gov (United States)

    Piszczor, Michael; McNatt, Jeremiah; Mercer, Carolyn; Kerslake, Tom; Pappa, Richard

    2012-01-01

    NASA is currently developing advanced solar cell and solar array technologies to support future exploration activities. These advanced photovoltaic technology development efforts are needed to enable very large (multi-hundred kilowatt) power systems that must be compatible with solar electric propulsion (SEP) missions. The technology being developed must address a wide variety of requirements and cover the necessary advances in solar cell, blanket integration, and large solar array structures that are needed for this class of missions. Th is paper will summarize NASA's plans for high power SEP missions, initi al mission studies and power system requirements, plans for advanced photovoltaic technology development, and the status of specific cell and array technology development and testing that have already been conducted.

  20. Cell Phones, Tablets, and Other Mobile Technology for Users with Visual Impairments

    Science.gov (United States)

    ... research. Share: Email Print Like (218 Likes) Cell Phones, Tablets, and Other Mobile Technology Touchscreen Smartphone Accessibility for People with Visual Impairments and Blindness The Benefits of Accessible Touchscreen Mobile Devices for People with ...

  1. Slit-scanning technique using standard cell sorter instruments for analyzing and sorting nonacrocentric human chromosomes, including small ones

    NARCIS (Netherlands)

    Rens, W.; van Oven, C. H.; Stap, J.; Jakobs, M. E.; Aten, J. A.

    1994-01-01

    We have investigated the performance of two types of standard flow cell sorter instruments, a System 50 Cytofluorograph and a FACSTar PLUS cell sorter, for the on-line centromeric index (CI) analysis of human chromosomes. To optimize the results, we improved the detection efficiency for centromeres

  2. A Standardized Method for In Vivo Mouse Pancreas Imaging and Semiquantitative β Cell Mass Measurement by Dual Isotope SPECT

    NARCIS (Netherlands)

    Mathijs, I.; Xavier, C.; Peleman, C.; Caveliers, V.; Brom, M.; Gotthardt, M.; Herrera, P.L.; Lahoutte, T.; Bouwens, L.

    2015-01-01

    In order to evaluate future β cell tracers in vivo, we aimed to develop a standardized in vivo method allowing semiquantitative measurement of a prospective β cell tracer within the pancreas.2-[(123)I]Iodo-L-phenylalanine ([(123)I]IPA) and [Lys(40)([(111)In]DTPA)]exendin-3 ([(111)In]Ex3) pancreatic

  3. A standardized method for in vivo mouse pancreas imaging and semiquantitative beta cell mass measurement by dual isotope SPECT

    NARCIS (Netherlands)

    Mathijs, I.; Xavier, C.; Peleman, C.; Caveliers, V.; Brom, M.; Gotthardt, M.; Herrera, P.L.; Lahoutte, T.; Bouwens, L.

    2015-01-01

    PURPOSE: In order to evaluate future beta cell tracers in vivo, we aimed to develop a standardized in vivo method allowing semiquantitative measurement of a prospective beta cell tracer within the pancreas. PROCEDURES: 2-[(123)I]Iodo-L-phenylalanine ([(123)I]IPA) and

  4. Development of materials for fuel cell application by radiation technology

    International Nuclear Information System (INIS)

    Rhee, Chang Kyu; Lee, Min Ku; Park, Junju; Lee, Gyoungja; Lee, Byung Cheol; Shin, Junhwa; Nho, Youngchang; Kang, Philhyun; Sohn, Joon Yong; Rang, Uhm Young

    2012-06-01

    The development of the single cell of SOFC with low operation temperature at and below 650 .deg. C(above 400 mW/cm 2 ) Ο The development of fabrication method for the single cell of solid oxide fuel cell (SOFC) by dip-coating of nanoparticles such as NiO, YSZ, Ag, and Ag/C, etc. Ο The optimization of the preparation and performance of SOFC by using nanoparticles. Ο The preparation of samples for SOFC with large dimension. The development of fluoropolymer-based fuel cell membranes with crosslinked structure by radiation grafting technique Ο The development of fuel cell membranes with low methanol permeability via the introduction of novel monomers (e. g. vinylbenzyl chloride and vinylether chloride) by radiation grafting technique Ο The development of hydrocarbon fuel cell membrane by radiation crosslinking technique Ο The structure analysis and the evaluations of the property, performance, and radiation effect of the prepared membranes Ο The optimization of the preparation and performance of DMFC fuel cell membrane via the structure-property analysis (power: above 130 mW/cm 2 /50 cm 2 at 5M methanol) Ο The preparation of samples for MEA stack assembly

  5. Proton exchange membrane fuel cell technology for transportation applications

    Energy Technology Data Exchange (ETDEWEB)

    Swathirajan, S. [General Motors R& D Center, Warren, MI (United States)

    1996-04-01

    Proton Exchange Membrane (PEM) fuel cells are extremely promising as future power plants in the transportation sector to achieve an increase in energy efficiency and eliminate environmental pollution due to vehicles. GM is currently involved in a multiphase program with the US Department of Energy for developing a proof-of-concept hybrid vehicle based on a PEM fuel cell power plant and a methanol fuel processor. Other participants in the program are Los Alamos National Labs, Dow Chemical Co., Ballard Power Systems and DuPont Co., In the just completed phase 1 of the program, a 10 kW PEM fuel cell power plant was built and tested to demonstrate the feasibility of integrating a methanol fuel processor with a PEM fuel cell stack. However, the fuel cell power plant must overcome stiff technical and economic challenges before it can be commercialized for light duty vehicle applications. Progress achieved in phase I on the use of monolithic catalyst reactors in the fuel processor, managing CO impurity in the fuel cell stack, low-cost electrode-membrane assembles, and on the integration of the fuel processor with a Ballard PEM fuel cell stack will be presented.

  6. Overview of micro- and nano-technology tools for stem cell applications: micropatterned and microelectronic devices.

    Science.gov (United States)

    Cagnin, Stefano; Cimetta, Elisa; Guiducci, Carlotta; Martini, Paolo; Lanfranchi, Gerolamo

    2012-11-19

    In the past few decades the scientific community has been recognizing the paramount role of the cell microenvironment in determining cell behavior. In parallel, the study of human stem cells for their potential therapeutic applications has been progressing constantly. The use of advanced technologies, enabling one to mimic the in vivo stem cell microenviroment and to study stem cell physiology and physio-pathology, in settings that better predict human cell biology, is becoming the object of much research effort. In this review we will detail the most relevant and recent advances in the field of biosensors and micro- and nano-technologies in general, highlighting advantages and disadvantages. Particular attention will be devoted to those applications employing stem cells as a sensing element.

  7. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: Fourth Results Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2013-01-01

    SunLine Transit Agency, which provides public transit services to the Coachella Valley area of California, has demonstrated hydrogen and fuel cell bus technologies for more than 10 years. In May 2010, SunLine began demonstrating the advanced technology (AT) fuel cell bus with a hybrid electric propulsion system, fuel cell power system, and lithium-based hybrid batteries. This report describes operations at SunLine for the AT fuel cell bus and five compressed natural gas buses. The U.S. Department of Energy's National Renewable Energy Laboratory (NREL) is working with SunLine to evaluate the bus in real-world service to document the results and help determine the progress toward technology readiness. NREL has previously published three reports documenting the operation of the fuel cell bus in service. This report provides a summary of the results with a focus on the bus operation from February 2012 through November 2012.

  8. Opinions of Art Teachers on the Standards of the International Society for Technology in Education: the Case of Western Mediterranean Region, Turkey

    Science.gov (United States)

    Konak, Armagan

    2018-01-01

    The purpose of this study, which is based on qualitative data, is to reveal the opinions of art teachers on the teacher standards set by the International Society for Technology in Education. It has been observed that the majority of participants of a study group are not aware of these standards, use social networks but do not use mobile…

  9. Essential Conditions for Technology-Supported, Student-Centered Learning: An Analysis of Student Experiences with Math Out Loud Using the ISTE Standards for Students

    Science.gov (United States)

    Dondlinger, Mary Jo; McLeod, Julie; Vasinda, Sheri

    2016-01-01

    This article explores links between student experiences with technology-rich mathematics instruction and the ISTE Standards for Students. Research methods applied constructivist grounded theory to analyze data from student interviews against the ISTE Standards for Students to identify which elements of the design of this learning environment…

  10. The Times They Are A-Changing: The Influence of Railroad Technology on the Adoption of Standard Time Zones in 1883.

    Science.gov (United States)

    Allen, Nathaniel

    2000-01-01

    Presents the story of the role railroad technology had in the adoption of Standard Time Zones in 1883 and also considers the influence of astronomers at the time. Includes the map of the standard railway time used by W. F. Allen and an annotated bibliography with primary and secondary sources. (CMK)

  11. Advanced technologies for plant cell wall evolution and diversity

    DEFF Research Database (Denmark)

    Fangel, Jonatan Ulrik

    Plant cell walls consist of polysaccharides, glycoproteins and phenolic polymers interlinked together in a highly complex network. The detailed analysis of cell walls is challenging because of their inherent complexity and heterogeneity. Also, complex carbohydrates, unlike proteins and nucleotides...... cannot really be synthesised or sequenced. The work described in this thesis is focused to a large extent on the development of a microarray-based high-throughput method for cell wall analysis known as Comprehensive microarray polymer profiling or CoMPP. The procedure uses highly specific molecular...... probes (monoclonal antibodies mAbs and carbohydrate binding modules, CBMs) to rapidly profile polysaccharides across a sample set. During my PhD I have further developed the CoMPP technique and used it for cell wall analysis within the context of a variety of applied and fundamental projects. The data...

  12. Future technology fuel cells; Zukunftstechnologie Brennstoffzelle. Themen 1999/2000

    Energy Technology Data Exchange (ETDEWEB)

    Hertlein, H.P. (comp.)

    2000-02-01

    The proceedings volume contains 14 papers and presents a survey of the state of the art of fuel cell developments. [German] Dieser Band gibt in 14 Beitraegen einen Ueberblick ueber den Stand der Entwicklung der Brennstoffzellen.

  13. Reconstruction of Ligament and Tendon Defects Using Cell Technologies.

    Science.gov (United States)

    Chailakhyan, R K; Shekhter, A B; Ivannikov, S V; Tel'pukhov, V I; Suslin, D S; Gerasimov, Yu V; Tonenkov, A M; Grosheva, A G; Panyushkin, P V; Moskvina, I L; Vorob'eva, N N; Bagratashvili, V N

    2017-02-01

    We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.

  14. The emergence of new technology-based industries: the case of fuel cells and its technological relatedness to regional knowledge bases

    DEFF Research Database (Denmark)

    Tanner, Anne Nygaard

    2016-01-01

    to emerging radical technologies that create the foundation for new industries. The article develops a new measure for technological relatedness between the knowledge base of a region and that of a radical technology based on patent classes. It demonstrates that emerging fuel cell technology develops where...... the regional knowledge base is technologically related to that of fuel cells and consequently confirms the evolutionary thesis.......Evolutionary economic geographers propose that regional diversification is a path-dependent process whereby industries grow out of pre-existing industrial structures through technologically related localised knowledge spillovers and learning. This article examines whether this also applies...

  15. Future of health technology assessment studies in gene and cell ...

    African Journals Online (AJOL)

    However, as should be noted, health care decisions need to be based on Health Technology Assessments (HTA) that should be based on objective criteria as efficacy, effectiveness, quality, safety, psychological, social, ethical, organisational and professional implications as well as cost effectiveness and further macro ...

  16. End-user satisfaction analysis on library management system unnes using technology acceptance model towards national standard of integrated library

    Science.gov (United States)

    Hardyanto, W.; Purwinarko, A.; Adhi, M. A.

    2018-03-01

    The library which is the gate of the University should be supported by the existence of an adequate information system, to provide excellent service and optimal to every user. Library management system that has been in existence since 2009 needs to be re-evaluated so that the system can meet the needs of both operator and Unnes user in particular, and users from outside Unnes in general. This study aims to evaluate and improve the existing library management system to produce a system that is accountable and able to meet the needs of end users, as well as produce a library management system that is integrated Unnes. Research is directed to produce evaluation report with Technology Acceptance Model (TAM) approach and library management system integrated with the national standard.

  17. Standard guide for mechanical drive systems for remote operation in hot cell facilities

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 Intent: 1.1.1 The intent of this standard is to provide general guidelines for the design, selection, quality assurance, installation, operation, and maintenance of mechanical drive systems used in remote hot cell environments. The term mechanical drive systems used herein, encompasses all individual components used for imparting motion to equipment systems, subsystems, assemblies, and other components. It also includes complete positioning systems and individual units that provide motive power and any position indicators necessary to monitor the motion. 1.2 Applicability: 1.2.1 This standard is intended to be applicable to equipment used under one or more of the following conditions: 1.2.1.1 The materials handled or processed constitute a significant radiation hazard to man or to the environment. 1.2.1.2 The equipment will generally be used over a long-term life cycle (for example, in excess of two years), but equipment intended for use over a shorter life cycle is not excluded. 1.2.1.3 The ...

  18. Microencapsulation Technology: A Powerful Tool for Integrating Expansion and Cryopreservation of Human Embryonic Stem Cells

    Science.gov (United States)

    Malpique, Rita; Brito, Catarina; Jensen, Janne; Bjorquist, Petter; Carrondo, Manuel J. T.; Alves, Paula M.

    2011-01-01

    The successful implementation of human embryonic stem cells (hESCs)-based technologies requires the production of relevant numbers of well-characterized cells and their efficient long-term storage. In this study, cells were microencapsulated in alginate to develop an integrated bioprocess for expansion and cryopreservation of pluripotent hESCs. Different three-dimensional (3D) culture strategies were evaluated and compared, specifically, microencapsulation of hESCs as: i) single cells, ii) aggregates and iii) immobilized on microcarriers. In order to establish a scalable bioprocess, hESC-microcapsules were cultured in stirred tank bioreactors. The combination of microencapsulation and microcarrier technology resulted in a highly efficient protocol for the production and storage of pluripotent hESCs. This strategy ensured high expansion ratios (an approximately twenty-fold increase in cell concentration) and high cell recovery yields (>70%) after cryopreservation. When compared with non-encapsulated cells, cell survival post-thawing demonstrated a three-fold improvement without compromising hESC characteristics. Microencapsulation also improved the culture of hESC aggregates by protecting cells from hydrodynamic shear stress, controlling aggregate size and maintaining cell pluripotency for two weeks. This work establishes that microencapsulation technology may prove a powerful tool for integrating the expansion and cryopreservation of pluripotent hESCs. The 3D culture strategy developed herein represents a significant breakthrough towards the implementation of hESCs in clinical and industrial applications. PMID:21850261

  19. STEM CELL TRANSPLANTATION AS A POSSIBLE STRATEGY FOR TREATING STANDARD THERAPY-RESISTANT ANKYLOSING SPONDYLITIS

    Directory of Open Access Journals (Sweden)

    I. Z. Gaidukova

    2016-01-01

    Full Text Available The authors have analyzed the literature dealing with studies of the efficiency and safety of stem cell transplantation (SCT in patients with ankylosing spondylitis (AS through the electronic resources Pubmed and Medline by using the keywords «bone marrow transplantation», «hematopoietic stem cell transplantation», «ankylosing spondylitis», «autoimmune diseases», and «sacroiliac joint biopsy». The paper describes four cases of SCT in AS patients, including transplantation that was carried out in one patient with lymphoma concurrent with AS, in two AS patients without blood cancers, and in one patient with AS concurrent with myeloid leukemia. Drug-free remission was achieved in 3 cases: lymphoma concurrent with AS (n=1, AS concurrent with myeloid leukemia (n=1, and AS without comorbidities (n=1. In addition to an improvement in the course of AS, there were also two cases with clinical presentations of AS after SCT. The given cases show that SCT can be basically used to induce drug-free remission in patients with severe forms of standard therapy-resistant AS. However, the introduction of SCT in clinical practice needs to adjust the technique to the specific features of AS patients. 

  20. solving the cell formation problem in group technology

    Directory of Open Access Journals (Sweden)

    Prafulla Joglekar

    2001-01-01

    Full Text Available Over the last three decades, numerous algorithms have been proposed to solve the work-cell formation problem. For practicing manufacturing managers it would be nice to know as to which algorithm would be most effective and efficient for their specific situation. While several studies have attempted to fulfill this need, most have not resulted in any definitive recommendations and a better methodology of evaluation of cell formation algorithms is urgently needed. Prima facie, the methodology underlying Miltenburg and Zhang's (M&Z (1991 evaluation of nine well-known cell formation algorithms seems very promising. The primary performance measure proposed by M&Z effectively captures the objectives of a good solution to a cell formation problem and is worthy of use in future studies. Unfortunately, a critical review of M&Z's methodology also reveals certain important flaws in M&Z's methodology. For example, M&Z may not have duplicated each algorithm precisely as the developer(s of that algorithm intended. Second, M&Z's misrepresent Chandrasekharan and Rajagopalan's [C&R's] (1986 grouping efficiency measure. Third, M&Z's secondary performance measures lead them to unnecessarily ambivalent results. Fourth, several of M&Z's empirical conclusions can be theoretically deduced. It is hoped that future evaluations of cell formation algorithms will benefit from both the strengths and weaknesses of M&Z's work.