Rodenbough, Philip P.; Vanti, William B.; Chan, Siu-Wai
Introductory materials science and engineering courses universally include the study of crystal structure and unit cells, which are by their nature highly visual 3D concepts. Traditionally, such topics are explored with 2D drawings or perhaps a limited set of difficult-to-construct 3D models. The rise of 3D printing, coupled with the wealth of…
Based on a review of the articles about methodological principles, and some research classifications, in this work an overview of the nature and status of science in Requirements Engineering is done...
Del Sol, Antonio; Thiesen, Hans J; Imitola, Jaime; Carazo Salas, Rafael E
Achieving the promises of stem cell science to generate precise disease models and designer cell samples for personalized therapeutics will require harnessing pheno-genotypic cell-level data quantitatively and predictively in the lab and clinic. Those requirements could be met by developing a Big-Data-driven stem cell science strategy and community. Copyright © 2017 Elsevier Inc. All rights reserved.
The background for the book is a quest for a thorough analysis of engineering, engineering science, and engineering education. Focusing on the concepts of engineering science, skills, and Bildung, the book investigates the real challenges that are confronting engineering today, and discusses how...
This book offers readers cutting-edge research at the interface of polymer science and engineering, biomedical engineering, materials science, and biology. State-of-the-art developments in microscale technologies for cell engineering applications are covered, including technologies relevant to both pluripotent and adult stem cells, the immune system, and somatic cells of the animal and human origin. This book bridges the gap in the understanding of engineering biology at multiple length scale, including microenvironmental control, bioprocessing, and tissue engineering in the areas of cardiac, cartilage, skeletal, and vascular tissues, among others. This book also discusses unique, emerging areas of micropatterning and three-dimensional printing models of cellular engineering, and contributes to the better understanding of the role of biophysical factors in determining the cell fate. Microscale Technologies for Cell Engineering is valuable for bioengineers, biomaterial scientists, tissue engineers, clinicians,...
During FY-96, work within the Materials Science and Engineering Thrust Area was focused on material modeling. Our motivation for this work is to develop the capability to study the structural response of materials as well as material processing. These capabilities have been applied to a broad range of problems, in support of many programs at Lawrence Livermore National Laboratory. These studies are described in (1) Strength and Fracture Toughness of Material Interfaces; (2) Damage Evolution in Fiber Composite Materials; (3) Flashlamp Envelope Optical Properties and Failure Analysis; (4) Synthesis and Processing of Nanocrystalline Hydroxyapatite; and (5) Room Temperature Creep Compliance of Bulk Kel-E.
National Science Foundation, 2016
"Science and Engineering Indicators" (SEI) is first and foremost a volume of record comprising high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI includes an overview and seven chapters that follow a generally consistent pattern. The chapter titles are as follows: (1) Elementary and…
Abstract. This paper is written with the intention of simulating discussion on teaching materials science and engineering in the universities. The article illustrates the tasks, priorities, goals and means lying ahead in the teaching of materials science and engineering for a sustainable future.
National Science Foundation, Washington, DC. National Science Board.
This volume is the ninth in the biennial "Science Indicators" series initiated by the National Science Board. The series provides a broad base of quantitative information about the structure and function of United States science and technology and comparisons with other advanced industrial countries. An overview of science and technology…
White, Susan; Arnold, James O. (Technical Monitor)
Trends in American society are changing the role of women in science and engineering, but all the elements in our society change at different rates. Women, like men, must choose during their teenage years to continue their training in math or science, or they close the door that can lead them to futures in the interesting and satisfying fields of science and engineering. The key is to keep girls involved in the hard sciences through the adolescent crisis. Many mentoring and outreach programs exist to help young women cross this threshold. These programs include hands-on science experiences, mentoring or putting young women in contact with women scientists and engineers, and internships, Viewpoints and histories of contemporary women engineers are discussed.
Block, David L. [Florida Solar Energy Center, Cocoa, FL (United States); Sleiti, Ahmad [Univ. of North Carolina, Charlotte, NC (United States)
The Hydrogen and Fuel Cell Technology education project has addressed DOE goals by supplying readily available, objective, technical, and accurate information that is available to students, industry and the public. In addition, the program has supplied educated trainers and training opportunities for the next generation workforce needed for research, development, and demonstration activities in government, industry, and academia. The project has successfully developed courses and associated laboratories, taught the new courses and labs and integrated the HFCT option into the accredited engineering technology and mechanical engineering programs at the University of North Carolina at Charlotte (UNCC). The project has also established ongoing collaborations with the UNCC energy related centers of the Energy Production & Infrastructure Center (EPIC), the NC Motorsports and Automotive Research Center (NCMARC) and the Infrastructure, Design, Environment and Sustainability Center (IDEAS). The results of the project activities are presented as two major areas – (1) course and laboratory development, offerings and delivery, and (2) program recruitment, promotions and collaborations. Over the project period, the primary activity has been the development and offering of 11 HFCT courses and accompanying laboratories. This process has taken three years with the courses first being developed and then offered each year over the timeframe.
This book draws together the most interesting recent results to emerge in mechanical engineering in Russia, providing a fascinating overview of the state of the art in the field in that country which will be of interest to a wide readership. A broad range of topics and issues in modern engineering are discussed, including dynamics of machines, materials engineering, structural strength and tribological behavior, transport technologies, machinery quality and innovations. The book comprises selected papers presented at the conference "Modern Engineering: Science and Education", held at the Saint Petersburg State Polytechnic University in 2014 with the support of the Russian Engineering Union. The authors are experts in various fields of engineering, and all of the papers have been carefully reviewed. The book will be of interest to mechanical engineers, lecturers in engineering disciplines and engineering graduates.
Lust, R.; Reinhard, R.
The engineering aspects of space probe development are examined. The study of the formation and evolution of the solar system is reviewed, focusing on additional information which could be gained from space probes. Consideration is given to the engineering requirements of space probe power supply, telemetry, tracking, command, attitude and orbit control, data-handling, and temperature control subsystems. An overview is given of the major space probe missions to Mercury, Venus, Mars, Jupiter, Saturn, Uranus, and comets.
The Journal of Applied Science, Engineering and Technology covers research activities and development in the field of Applied Sciences and Technology as it relates to Agricultural Engineering, Biotechnology, Computer Science and Engineering Computations, Civil Engineering, Food Science and Technology, Electrical ...
con- tributions; Vellamo Lahti, SRS, provided secretarial support; and Martha James provided administrative assistance. Overall editing of the report...NO COO N LO COOCC (0 0 0LO 0NC C C O 0 qm 0) N i-N.-q NN (0(’t CO CO. m CO. CONC NO M) - CO (0( C0 a)( -00) F, LA~ ~~~ LAmA mOC0 0 NLLA 0NOiL N . A- N...Foundation Martha A. Krebs, Department of Energy Lawrence Burton, National Science Foundation Carlos Kruytbosch, National Science Foundation Ronald E
The science-based stockpile stewardship program emphasizes a better understanding of how complex components function through advanced computer calculations. Many of the problem areas are in the behavior of materials making up the equipment. The Los Alamos Neutron Science Center (LANSCE) can contribute to solving these problems by providing diagnostic tools to examine parts noninvasively and by providing the experimental tools to understand material behavior in terms of both the atomic structure and the microstructure. Advanced computer codes need experimental information on material behavior in response to stress, temperature, and pressure as input, and they need benchmarking experiments to test the model predictions for the finished part.
Davy, Anne Mathilde; Kildegaard, Helene Faustrup; Andersen, Mikael Rørdam
focused on individual strategies or cell types, but collectively they fall under the broad umbrella of a growing field known as cell factory engineering. Here we condense >130 reviews and key studies in the art into a meta-review of cell factory engineering. We identified 33 generic strategies......-review provides general strategy guides for the broad range of applications of rational engineering of cell factories....
Regtien, Paulus P.L.; van der Heijden, Ferdinand; Korsten, Maarten J.; Olthuis, Wouter
This volume, from an international authority on the subject, deals with the physical and instrumentation aspects of measurement science, the availability of major measurement tools, and how to use them. This book not only lays out basic concepts of electronic measurement systems, but also provides
Structures cannot be created without engineering theory, and design rules have existed from the earliest times for building Greek temples, Roman aqueducts and Gothic cathedrals - and later, for steel skyscrapers and the frames for aircraft. This book is, however, not concerned with the description of historical feats, but with the way the structural engineer sets about his business. Galileo, in the seventeenth century, was the first to introduce recognizably modern science into the calculation of structures; he determined the breaking strength of beams. In the eighteenth century engineers move
“Cell and Tissue Engineering” introduces the principles and new approaches in cell and tissue engineering. It includes both the fundamentals and the current trends in cell and tissue engineering, in a way useful both to a novice and an expert in the field. The book is composed of 13 chapters all of which are written by the leading experts. It is organized to gradually assemble an insight in cell and tissue function starting form a molecular nano-level, extending to a cellular micro-level and finishing at the tissue macro-level. In specific, biological, physiological, biophysical, biochemical, medical, and engineering aspects are covered from the standpoint of the development of functional substitutes of biological tissues for potential clinical use. Topics in the area of cell engineering include cell membrane biophysics, structure and function of the cytoskeleton, cell-extracellular matrix interactions, and mechanotransduction. In the area of tissue engineering the focus is on the in vitro cultivation of ...
Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...
Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...
This paper is concerned with scientific reasoning in the engineering sciences. Engineering sciences aim at explaining, predicting and describing physical phenomena occurring in technological devices. The focus of this paper is on mathematical description. These mathematical descriptions are
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Nystrom, Lynn A.
Ishwar K. Puri, professor of mechanical engineering and executive associate dean of engineering at the University of Illinois at Chicago, will become the head of Virginia Tech•À_ó»s Department of Engineering Science and Mechanics Aug. 1.
This article presents a single case study of an experienced physical science teacher (Janet) integrating engineering practices into her urban science classroom over a two-year time frame. The article traces how Janet's understanding of the role engineering in her teaching expanded beyond engineering as an application of science and mathematics to…
In the historiography of the relationship between technology and theoretical science, electrical communication plays an important role. It was by means of mathematical reasoning based on the new theory of electromagnetism that it was first understood how to extend the range of telephony by insert......In the historiography of the relationship between technology and theoretical science, electrical communication plays an important role. It was by means of mathematical reasoning based on the new theory of electromagnetism that it was first understood how to extend the range of telephony...... by inserting self-inductance in the line. This paper surveys developments from around 1880 to 1910, at a time when 'pupinization' had become a reality and mathematical physics an accepted part of the research strategy of a few advanced companies in the electrical industry. It presents the confrontation of two...... different styles of engineering science, on the one hand there was the empirical approach and on the other an approach more mathematical in nature. This paper offers some reflections on the nature of 'counterintuitive technologies' and the general relationship between science, engineering and technology....
Journal of Applied Science Engineering and Technology accepts and publishes articles on Engineering, Physical Sciences and all fields of Technology and ... Geology, Industrial, Production & Manufacturing Engineering, Mechanical Engineering, Petroleum Engineering, Physics and other related Applied Sciences and ...
"Innovations in Computing Sciences and Software Engineering" includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Software Engineering, Computer Engineering, and Systems Engineering and Sciences. The topics covered include: Image and Pattern Recognition: Compression, Image processing, Signal Processing Architectures, Signal Processing for Communication, Signal Processing Implementation, Speech Compression, and Video Coding Architectures; Languages and Systems: Algorithms, Databases,
The aim of this paper is to clarify the identity of food engineering in sciences of food. A short historical description of the evolution of the branch in the Anglo Saxon and the Continental educational systems is given. Furthermore, the distinction of basic definitions such as food science, food science and technology, food technology, and food engineering is made. Finally, the objectives of food engineering within the branch of sciences of food are described.
Full Text Available The aim of this paper is to clarify the identity of food engineering in sciences of food. A short historical description of the evolution of the branch in the Anglo Saxon and the Continental educational systems is given. Furthermore, the distinction of basic definitions such as food science, food science and technology, food technology, and food engineering is made. Finally, the objectives of food engineering within the branch of sciences of food are described.
Maki, Justin N.; Thiessen, David L.; Pourangi, Ali M.; Kobzeff, Peter A.; Lee, Steven W.; Dingizian, Arsham; Schwochert, Mark A.
NASA's Mars Science Laboratory (MSL) Rover, which launched to Mars in 2011, is equipped with a set of 12 engineering cameras. These cameras are build-to-print copies of the Mars Exploration Rover (MER) cameras, which were sent to Mars in 2003. The engineering cameras weigh less than 300 grams each and use less than 3 W of power. Images returned from the engineering cameras are used to navigate the rover on the Martian surface, deploy the rover robotic arm, and ingest samples into the rover sample processing system. The navigation cameras (Navcams) are mounted to a pan/tilt mast and have a 45-degree square field of view (FOV) with a pixel scale of 0.82 mrad/pixel. The hazard avoidance cameras (Haz - cams) are body-mounted to the rover chassis in the front and rear of the vehicle and have a 124-degree square FOV with a pixel scale of 2.1 mrad/pixel. All of the cameras utilize a frame-transfer CCD (charge-coupled device) with a 1024x1024 imaging region and red/near IR bandpass filters centered at 650 nm. The MSL engineering cameras are grouped into two sets of six: one set of cameras is connected to rover computer A and the other set is connected to rover computer B. The MSL rover carries 8 Hazcams and 4 Navcams.
Lynggaard, Hans Jørgen Birk; Alting, Leo
The engineering process of creating cell control systems is described, and a Cell Control Engineering (CCE) concept is defined. The purpose is to assist people, representing different disciplines in the organisation, to implement cell controllers by addressing the complexity of having many systems...... in physically and logically different and changing manufacturing environments. The defined CCE concept combines state-of-the-art of commercially available enabling technologies for automation system software development, generic cell control models and guidelines for the complete engineering process....... It facilitates the understanding of the task and structure of cell controllers and uses this knowledge directly in the implementation of the system. By applying generic models CCE facilitates reuse of software components and maintenance of applications. In many enterprises, software makes up an increasing part...
Second International Conference on Advances in Computer Science and Engineering (CES 2012)
This book includes the proceedings of the second International Conference on Advances in Computer Science and Engineering (CES 2012), which was held during January 13-14, 2012 in Sanya, China. The papers in these proceedings of CES 2012 focus on the researchers’ advanced works in their fields of Computer Science and Engineering mainly organized in four topics, (1) Software Engineering, (2) Intelligent Computing, (3) Computer Networks, and (4) Artificial Intelligence Software.
I use the 1993 and 2003 National Surveys of College Graduates to examine the higher exit rate of women compared to men from science and engineering relative to other fields. I find that the higher relative exit rate is driven by engineering rather than science, and show that 60\\% of the gap can be explained by the relatively greater exit rate from engineering of women dissatisfied with pay and promotion opportunities. Contrary to the existing literature, I find that family--related constraint...
Hahn, Heidi A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
The purpose of this report is to promote the three key elements of engineering capabilities, staff and engagement in coordination with an R&D investment cycle; and establish an Engineering Steering Council to own and guide this leadership plan.
In recent years, the life sciences have embraced simulation as an important tool in biomedical research. Engineers are also using simulation as a powerful step in the design process. In both arenas, Matlab has become the gold standard. It is easy to learn, flexible, and has a large and growing userbase. MATLAB for Engineering and the Life Sciences is a self-guided tour of the basic functionality of MATLAB along with the functions that are most commonly used in biomedical engineering and other life sciences. Although the text is written for undergraduates, graduate students and academics, those
This book draws together the most interesting recent results to emerge in mechanical engineering in Russia, providing a fascinating overview of the state of the art in the field in that country which will be of interest to a wide readership. A broad range of topics and issues in modern engineering are discussed, including dynamics of machines, materials engineering, structural strength and tribological behavior, transport technologies, machinery quality and innovations. The book comprises selected papers presented at the conference "Modern Engineering: Science and Education", held at the Saint Petersburg State Polytechnic University in 2016 with the support of the Russian Engineering Union. The authors are experts in various fields of engineering, and all of the papers have been carefully reviewed. The book will be of interest to mechanical engineers, lecturers in engineering disciplines and engineering graduates.
Hacioglu, Yasemin; Yamak, Havva; Kavak, Nusret
The aim of this study is to reveal pre-service science teachers' cognitive structures regarding Science, Technology, Engineering, Mathematics (STEM) and science education. The study group of the study consisted of 192 pre-service science teachers. A Free Word Association Test (WAT) consisting of science, technology, engineering, mathematics and…
Cell-free synthetic biology emerges as a powerful and flexible enabling technology that can engineer biological parts and systems for life science applications without using living cells. It provides simpler and faster engineering solutions with an unprecedented freedom of design in an open environment than cell system. This review focuses on recent developments of cell-free synthetic biology on biological engineering fields at molecular and cellular levels, including protein engineering, met...
Learn how to use Mathcad in the context of engineering, science, and math applications. Appropriate for first time users and for experienced users who want to use Mathcad to organize their larger projects
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Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part II: from genes to networks: tissue engineering from the viewpoint of systems biology and network science.
Lenas, Petros; Moos, Malcolm; Luyten, Frank P
The field of tissue engineering is moving toward a new concept of "in vitro biomimetics of in vivo tissue development." In Part I of this series, we proposed a theoretical framework integrating the concepts of developmental biology with those of process design to provide the rules for the design of biomimetic processes. We named this methodology "developmental engineering" to emphasize that it is not the tissue but the process of in vitro tissue development that has to be engineered. To formulate the process design rules in a rigorous way that will allow a computational design, we should refer to mathematical methods to model the biological process taking place in vitro. Tissue functions cannot be attributed to individual molecules but rather to complex interactions between the numerous components of a cell and interactions between cells in a tissue that form a network. For tissue engineering to advance to the level of a technologically driven discipline amenable to well-established principles of process engineering, a scientifically rigorous formulation is needed of the general design rules so that the behavior of networks of genes, proteins, or cells that govern the unfolding of developmental processes could be related to the design parameters. Now that sufficient experimental data exist to construct plausible mathematical models of many biological control circuits, explicit hypotheses can be evaluated using computational approaches to facilitate process design. Recent progress in systems biology has shown that the empirical concepts of developmental biology that we used in Part I to extract the rules of biomimetic process design can be expressed in rigorous mathematical terms. This allows the accurate characterization of manufacturing processes in tissue engineering as well as the properties of the artificial tissues themselves. In addition, network science has recently shown that the behavior of biological networks strongly depends on their topology and has
Cell-free synthetic biology emerges as a powerful and flexible enabling technology that can engineer biological parts and systems for life science applications without using living cells. It provides simpler and faster engineering solutions with an unprecedented freedom of design in an open environment than cell system. This review focuses on recent developments of cell-free synthetic biology on biological engineering fields at molecular and cellular levels, including protein engineering, metabolic engineering, and artificial cell engineering. In cell-free protein engineering, the direct control of reaction conditions in cell-free system allows for easy synthesis of complex proteins, toxic proteins, membrane proteins, and novel proteins with unnatural amino acids. Cell-free systems offer the ability to design metabolic pathways towards the production of desired products. Buildup of artificial cells based on cell-free systems will improve our understanding of life and use them for environmental and biomedical applications.
Full Text Available Cell-free synthetic biology emerges as a powerful and flexible enabling technology that can engineer biological parts and systems for life science applications without using living cells. It provides simpler and faster engineering solutions with an unprecedented freedom of design in an open environment than cell system. This review focuses on recent developments of cell-free synthetic biology on biological engineering fields at molecular and cellular levels, including protein engineering, metabolic engineering, and artificial cell engineering. In cell-free protein engineering, the direct control of reaction conditions in cell-free system allows for easy synthesis of complex proteins, toxic proteins, membrane proteins, and novel proteins with unnatural amino acids. Cell-free systems offer the ability to design metabolic pathways towards the production of desired products. Buildup of artificial cells based on cell-free systems will improve our understanding of life and use them for environmental and biomedical applications.
Amouzegar, Mahyar; Ao, Sio-long
This volume contains thirty-nine revised and extended research articles, written by prominent researchers participating in the World Congress on Engineering and Computer Science 2014, held in San Francisco, October 22-24 2014. Topics covered include engineering mathematics, electrical engineering, circuit design, communications systems, computer science, chemical engineering, systems engineering, and applications of engineering science in industry. This book describes some significant advances in engineering technologies, and also serves as an excellent source of reference for researchers and graduate students.
Fuzzy logic is a relatively new concept in science applications. Hitherto, fuzzy logic has been a conceptual process applied in the field of risk management. Its potential applicability is much wider than that, however, and its particular suitability for expanding our understanding of processes and information in science and engineering in our post-modern world is only just beginning to be appreciated. Written as a companion text to the author's earlier volume "An Introduction to Fuzzy Logic Applications", the book is aimed at professional engineers and students and those with an interest in exploring the potential of fuzzy logic as an information processing kit with a wide variety of practical applications in the field of engineering science and develops themes and topics introduced in the author's earlier text.
How to integrate simulation-based engineering and science (SBES) into the science curriculum smoothly is a challenging question. For the importance of SBES to be appreciated, the core value of simulations-that they help people understand natural phenomena and solve engineering problems-must be taught. A strategy to achieve this goal is to introduce computational experiments to the science curriculum to replace or supplement textbook illustrations and exercises and to complement or frame hands-on or wet lab experiments. In this way, students will have an opportunity to learn about SBES without compromising other learning goals required by the standards and teachers will welcome these tools as they strengthen what they are already teaching. This paper demonstrates this idea using a number of examples in physics, chemistry, and engineering. These exemplary computational experiments show that it is possible to create a curriculum that is both deeper and wider.
Steels and computer-based modelling are fast growing fields in materials science as well as structural engineering, demonstrated by the large amount of recent literature. Steels: From Materials Science to Structural Engineering combines steels research and model development, including the application of modelling techniques in steels. The latest research includes structural engineering modelling, and novel, prototype alloy steels such as heat-resistant steel, nitride-strengthened ferritic/martensitic steel and low nickel maraging steel. Researchers studying steels will find the topics vital to their work. Materials experts will be able to learn about steels used in structural engineering as well as modelling and apply this increasingly important technique in their steel materials research and development.
An enormous array of problems encountered by scientists and engineers are based on the design of mathematical models using many different types of ordinary differential, partial differential, integral, and integro-differential equations. Accordingly, the solutions of these equations are of great interest to practitioners and to science in general. Presenting a wealth of cutting-edge research by a diverse group of experts in the field, Integral Methods in Science and Engineering: Computational and Analytic Aspects gives a vivid picture of both the development of theoretical integral techniques
Full Text Available The development of biological and biomaterial sciences profiled tissue engineering as a new and powerful tool for biological replacement of organs. The combination of stem cells and suitable scaffolds is widely used in experiments today, in order to achieve partial or whole organ regeneration. This review focuses on the use of tissue engineering strategies in tooth regeneration, using stem cells and stem cells/scaffold constructs. Although whole tooth regeneration is still not possible, there are promising results. However, to achieve this goal, it is important to understand and further explore the mechanisms underlying tooth development. Only then will we be able to mimic the natural processes with the use of stem cells and tissue engineering techniques.
Gwyther, J L; Williams, G
0.1 Mechanical Engineering Science covers various fundamental concepts that are essential in the practice of mechanical engineering. The title is comprised of 19 chapters that detail various topics, including chemical and physical laws. The coverage of the book includes Newtonian laws, mechanical energy, friction, stress, and gravity. The text also discusses the chemical aspects of mechanical engineering, which include gas laws, states of matter, and fuel combustion. The last chapter tackles concerns in laboratory experiments. The book will be of great use to students of mechanical eng
Kofoed, Lise B.; S. Stachowicz, Marian
creating new knowledge. We will address the challenges by defining the term interdisciplinary in connection with education, and using the Problem Based Learning educational approach and experience from the engineering and science educational areas to find the obstacles. Two cases based on interdisciplinary...
Mathematical models, along with scientific theory and practical experiments, are a crucial part of modern engineering and science. The author takes a look at the role mathematical models play in topics ranging from vascular simulation to weather forecasting to designing America's Cup sailboats.
Batcheller, Archer L.
Software has an important role in supporting scientific work. This dissertation studies teams that build scientific software, focusing on the way that they determine what the software should do. These requirements engineering processes are investigated through three case studies of climate science software projects. The Earth System Modeling…
Mitchell, Michael J; Jain, Rakesh K; Langer, Robert
The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: the physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas.
Luna, Bernadette; Kliss, Mark (Technical Monitor)
The presentation will focus on topics of interest to young women pursuing an engineering or scientific career, such as intrinsic personality traits of most engineers, average salaries for the various types of engineers, appropriate preparation classes at the high school and undergraduate levels, gaining experience through internships, summer jobs and graduate school, skills necessary but not always included in engineering curricula (i.e., multimedia, computer skills, communication skills), the work environment, balancing family and career, and sexual harassment. Specific examples from the speaker's own experience in NASA's Space Life Sciences Program will be used to illustrate the above topics. In particular, projects from Extravehicular Activity and Protective Systems research and Regenerative Life Support research will be used as examples of real world problem-solving to enable human exploration of the solar system.
Hamilton, Robert V.
This dissertation analyzes the nearly 100,000 foreign students who attained science and engineering (S&E) doctorates in the five fields of physical sciences, life sciences, engineering, mathematics and computer sciences, and social and behavioral sciences at American universities from 1994 to 2005. Two models are presented. In the first model…
It is always stressed that hydrological modelling is very important, to prevent floods, to mitigate droughts, to ensure food production or nature conservation. All very true, but I believe that focussing so much on the application of our knowledge (which I call `the engineering approach'), does not stimulate thorough system understanding (which I call `the scientific approach'). In many studies, science and engineering approaches are mixed, which results in large uncertainty e.g. due to a lack of system understanding. To what extent engineering and science approached are mixed depends on the Philosophy of Science of the researcher; verificationism seems to be closer related to engineering, than falsificationism or Bayesianism. In order to grow our scientific knowledge, which means increasing our understanding of the system, we need to be more critical towards the models that we use, but also recognize all the processes that influence the hydrological cycle. In an era called 'The Anthropocene' the influence of humans on the water system can no longer be neglected, and if we choose a scientific approach we have to account for human-induced processes. Summarizing, I believe that we have to account for human impact on the hydrological system, but we have to resist the temptation to directly quantify the hydrological impact on the human system.
Lesieutre, George A.; Stewart, Susan W.; Bridgen, Marc
Broadly, this project involved the development and delivery of a new curriculum in wind energy engineering at the Pennsylvania State University; this includes enhancement of the Renewable Energy program at the Pennsylvania College of Technology. The new curricula at Penn State includes addition of wind energy-focused material in more than five existing courses in aerospace engineering, mechanical engineering, engineering science and mechanics and energy engineering, as well as three new online graduate courses. The online graduate courses represent a stand-alone Graduate Certificate in Wind Energy, and provide the core of a Wind Energy Option in an online intercollege professional Masters degree in Renewable Energy and Sustainability Systems. The Pennsylvania College of Technology erected a 10 kilowatt Xzeres wind turbine that is dedicated to educating the renewable energy workforce. The entire construction process was incorporated into the Renewable Energy A.A.S. degree program, the Building Science and Sustainable Design B.S. program, and other construction-related coursework throughout the School of Construction and Design Technologies. Follow-on outcomes include additional non-credit opportunities as well as secondary school career readiness events, community outreach activities, and public awareness postings.
Stahl, H. Philip; Arnold, William; Bevan, Ryan M.; Smith, W. Scott; Kirk, Charles S.; Postman, Marc
Advanced Mirror Technology Development (AMTD) is a multi-year effort to systematically mature to TRL-6 the critical technologies needed to produce 4-m or larger flight-qualified UVOIR mirrors by 2018 so that a viable mission can be considered by the 2020 Decadal Review. This technology must enable missions capable of both general astrophysics & ultra-high contrast observations of exoplanets. To accomplish our objective, we use a science-driven systems engineering approach. We mature technologies required to enable the highest priority science AND result in a high-performance low-cost low-risk system.
Dr. Wynn Volkert; Dr. Arvind Kumar; Dr. Bryan Becker; Dr. Victor Schwinke; Dr. Angel Gonzalez; Dr. DOuglas McGregor
The objective of the Midwest Nuclear Science and Engineering Consortium (MNSEC) is to enhance the scope, quality and integration of educational and research capabilities of nuclear sciences and engineering (NS/E) programs at partner schools in support of the U.S. nuclear industry (including DOE laboratories). With INIE support, MNSEC had a productive seven years and made impressive progress in achieving these goals. Since the past three years have been no-cost-extension periods, limited -- but notable -- progress has been made in FY10. Existing programs continue to be strengthened and broadened at Consortium partner institutions. The enthusiasm generated by the academic, state, federal, and industrial communities for the MNSEC activities is reflected in the significant leveraging that has occurred for our programs.
Kim, Haeng; Amouzegar, Mahyar
This proceedings volume contains selected revised and extended research articles written by researchers who participated in the World Congress on Engineering and Computer Science 2015, held in San Francisco, USA, 21-23 October 2015. Topics covered include engineering mathematics, electrical engineering, circuits, communications systems, computer science, chemical engineering, systems engineering, manufacturing engineering, and industrial applications. The book offers the reader an overview of the state of the art in engineering technologies, computer science, systems engineering and applications, and will serve as an excellent reference work for researchers and graduate students working in these fields.
Knowledge is the most precious ingredient facilitating aerospace engineering research and product development activities. Currently, the most common knowledge retention methods are paper-based documents, such as reports, books and journals. However, those media have innate weaknesses. For example, four generations of flying wing aircraft (Horten, Northrop XB-35/YB-49, Boeing BWB and many others) were mostly developed in isolation. The subsequent engineers were not aware of the previous developments, because these projects were documented such which prevented the next generation of engineers to benefit from the previous lessons learned. In this manner, inefficient knowledge retention methods have become a primary obstacle for knowledge transfer from the experienced to the next generation of engineers. In addition, the quality of knowledge itself is a vital criterion; thus, an accurate measure of the quality of 'knowledge' is required. Although qualitative knowledge evaluation criteria have been researched in other disciplines, such as the AAA criterion by Ernest Sosa stemming from the field of philosophy, a quantitative knowledge evaluation criterion needs to be developed which is capable to numerically determine the qualities of knowledge for aerospace engineering research and product development activities. To provide engineers with a high-quality knowledge management tool, the engineering science discipline Knowledge Engineering has been formalized to systematically address knowledge retention issues. This research undertaking formalizes Knowledge Engineering as follows: 1. Categorize knowledge according to its formats and representations for the first time, which serves as the foundation for the subsequent knowledge management function development. 2. Develop an efficiency evaluation criterion for knowledge management by analyzing the characteristics of both knowledge and the parties involved in the knowledge management processes. 3. Propose and develop an
Lowndes, D. H.; Alivisatos, A. P.; Alper, M.; Averback, R. S.; Jacob Barhen, J.; Eastman, J. A.; Imre, D.; Lowndes, D. H.; McNulty, I.; Michalske, T. A.; Ho, K-M; Nozik, A. J.; Russell, T. P.; Valentin, R. A.; Welch, D. O.; Barhen, J.; Agnew, S. R.; Bellon, P.; Blair, J.; Boatner, L. A.; Braiman, Y.; Budai, J. D.; Crabtree, G. W.; Feldman, L. C.; Flynn, C. P.; Geohegan, D. B.; George, E. P.; Greenbaum, E.; Grigoropoulos, C.; Haynes, T. E.; Heberlein, J.; Hichman, J.; Holland, O. W.; Honda, S.; Horton, J. A.; Hu, M. Z.-C.; Jesson, D. E.; Joy, D. C.; Krauss, A.; Kwok, W.-K.; Larson, B. C.; Larson, D. J.; Likharev, K.; Liu, C. T.; Majumdar, A.; Maziasz, P. J.; Meldrum, A.; Miller, J. C.; Modine, F. A.; Pennycook, S. J.; Pharr, G. M.; Phillpot, S.; Price, D. L.; Protopopescu, V.; Poker, D. B.; Pui, D.; Ramsey, J. M.; Rao, N.; Reichl, L.; Roberto, J.; Saboungi, M-L; Simpson, M.; Strieffer, S.; Thundat, T.; Wambsganss, M.; Wendleken, J.; White, C. W.; Wilemski, G.; Withrow, S. P.; Wolf, D.; Zhu, J. H.; Zuhr, R. A.; Zunger, A.; Lowe, S.
This report describes important future research directions in nanoscale science, engineering and technology. It was prepared in connection with an anticipated national research initiative on nanotechnology for the twenty-first century. The research directions described are not expected to be inclusive but illustrate the wide range of research opportunities and challenges that could be undertaken through the national laboratories and their major national scientific user facilities with the support of universities and industry.
Zhou, M; Weijnen, M
This volume provides a comprehensive overview of all important areas in systems science and engineering and poses the issues and challenges in these areas in order to deal with ever-increasingly complex systems and newly emergent applications. The topics range from discrete event systems, distributed intelligent systems, grey systems, and enterprise information systems to conflict resolution, robotics and intelligent sensing, smart grids, and system of systems approaches. Individual chapters are written by leading experts in the field.
Van Brussel, Hendrik Van Brussel; Lindberg, Bengt; Cederwall, Klas
This report presents the conclusions of Panel 1: Construction engineering, Production and Operation. The Research Council of Norway (NFR) appointed three expert panels to evaluate Research in Engineering Science in Norway .......This report presents the conclusions of Panel 1: Construction engineering, Production and Operation. The Research Council of Norway (NFR) appointed three expert panels to evaluate Research in Engineering Science in Norway ....
Bell, Peter M.
The overall number of job offers this spring to college graduates at the bachelor's degree level dropped by more than 11,000—from 62,835 last year to 51,200—according to data just compiled by the College Placement Council in its Salog Survey report. This is the first decrease in 6 years. Despite the fact that the number of offers was down in many categories, the actual starting salaries did not suffer, and science and engineering graduates commanded the highest figures of all categories. At the bachelor's level, petroleum engineering majors drew the highest annual salary at $30,468.00. This salary was increased over last year's average for petroleum engineers by about 14.3%.
Rappaz, Michel; Deville, Michel
This book introduces the concepts and methodologies related to the modelling of the complex phenomena occurring in materials processing. After a short reminder of conservation laws and constitutive relationships, the authors introduce the main numerical methods: finite differences, finite volumes and finite elements. These techniques are developed in three main chapters of the book that tackle more specific problems: phase transformation, solid mechanics and fluid flow. The two last chapters treat inverse methods to obtain the boundary conditions or the material properties and stochastic methods for microstructural simulation. This book is intended for undergraduate and graduate students in materials science and engineering, mechanical engineering and physics and for engineering professionals or researchers who want to get acquainted with numerical simulation to model and compute materials processing.
The Second SIAM Conference on Computational Science and Engineering was held in San Diego from February 10-12, 2003. Total conference attendance was 553. This is a 23% increase in attendance over the first conference. The focus of this conference was to draw attention to the tremendous range of major computational efforts on large problems in science and engineering, to promote the interdisciplinary culture required to meet these large-scale challenges, and to encourage the training of the next generation of computational scientists. Computational Science & Engineering (CS&E) is now widely accepted, along with theory and experiment, as a crucial third mode of scientific investigation and engineering design. Aerospace, automotive, biological, chemical, semiconductor, and other industrial sectors now rely on simulation for technical decision support. For federal agencies also, CS&E has become an essential support for decisions on resources, transportation, and defense. CS&E is, by nature, interdisciplinary. It grows out of physical applications and it depends on computer architecture, but at its heart are powerful numerical algorithms and sophisticated computer science techniques. From an applied mathematics perspective, much of CS&E has involved analysis, but the future surely includes optimization and design, especially in the presence of uncertainty. Another mathematical frontier is the assimilation of very large data sets through such techniques as adaptive multi-resolution, automated feature search, and low-dimensional parameterization. The themes of the 2003 conference included, but were not limited to: Advanced Discretization Methods; Computational Biology and Bioinformatics; Computational Chemistry and Chemical Engineering; Computational Earth and Atmospheric Sciences; Computational Electromagnetics; Computational Fluid Dynamics; Computational Medicine and Bioengineering; Computational Physics and Astrophysics; Computational Solid Mechanics and Materials; CS
Chudler, Eric H.; Bergsman, Kristen Clapper
Neural engineering is an emerging field of high relevance to students, teachers, and the general public. This feature presents online resources that educators and scientists can use to introduce students to neural engineering and to integrate core ideas from the life sciences, physical sciences, social sciences, computer science, and engineering…
Ma, Ming-San; Boddeke, Erik; Copray, Sjef
Tissue engineering of Schwann cells (SCs) can serve a number of purposes, such as in vitro SC-related disease modeling, treatment of peripheral nerve diseases or peripheral nerve injury, and, potentially, treatment of CNS diseases. SCs can be generated from autologous stem cells in vitro by
Support made scholarships available to minority and women students interested in engineering and science and significantly increased : the number of minority and female students that Missouri S&T can recruit to its science and engineering programs. R...
Support will make scholarships available to minority and women students interested in engineering and science and will increase : significantly the number of minority and female students that Missouri S&T can recruit to its science and engineering pr...
Ao, Sio-Iong; Amouzegar, Mahyar
This volume contains fifty-six revised and extended research articles, written by prominent researchers participating in the congress. Topics covered include electrical engineering, chemical engineering, circuits, computer science, communications systems, engineering mathematics, systems engineering, manufacture engineering, and industrial applications. This book offers theoretical advances in engineering technologies, and presents state of the art applications. It also serves as an excellent source of reference for researchers and graduate students working with/on engineering technologies.
Peterman, Karen; Daugherty, Jenny L.; Custer, Rodney L.; Ross, Julia M.
Science teachers are being called on to incorporate engineering practices into their classrooms. This study explores whether the Engineering-Infused Lesson Rubric, a new rubric designed to target best practices in engineering education, could be used to evaluate the extent to which engineering is infused into online science lessons. Eighty lessons…
Wang, Qun; Cheng, Hao; Peng, Haisheng; Zhou, Hao; Li, Peter Y; Langer, Robert
Cell-based therapy is a promising modality to address many unmet medical needs. In addition to genetic engineering, material-based, biochemical, and physical science-based approaches have emerged as novel approaches to modify cells. Non-genetic engineering of cells has been applied in delivering therapeutics to tissues, homing of cells to the bone marrow or inflammatory tissues, cancer imaging, immunotherapy, and remotely controlling cellular functions. This new strategy has unique advantages in disease therapy and is complementary to existing gene-based cell engineering approaches. A better understanding of cellular systems and different engineering methods will allow us to better exploit engineered cells in biomedicine. Here, we review non-genetic cell engineering techniques and applications of engineered cells, discuss the pros and cons of different methods, and provide our perspectives on future research directions. Copyright © 2014 Elsevier B.V. All rights reserved.
Montaser, Laila M.; Fawzy, Sherin M.
Tissue engineering and regenerative medicine have been constantly developing of late due to the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Although stem cells hold great potential for the treatment of many injuries and degenerative diseases, several obstacles must be overcome before their therapeutic application can be realized. These include the development of advanced techniques to understand and control functions of micro environmental signals and novel methods to track and guide transplanted stem cells. A major complication encountered with stem cell therapies has been the failure of injected cells to engraft to target tissues. The application of nanotechnology to stem cell biology would be able to address those challenges. Combinations of stem cell therapy and nanotechnology in tissue engineering and regenerative medicine have achieved significant advances. These combinations allow nanotechnology to engineer scaffolds with various features to control stem cell fate decisions. Fabrication of Nano fiber cell scaffolds onto which stem cells can adhere and spread, forming a niche-like microenvironment which can guide stem cells to proceed to heal damaged tissues. In this paper, current and emergent approach based on stem cells in the field of liver tissue engineering is presented for specific application. The combination of stem cells and tissue engineering opens new perspectives in tissue regeneration for stem cell therapy because of the potential to control stem cell behavior with the physical and chemical characteristics of the engineered scaffold environment.
The aim of this Conference was to become a forum for discussion of both academic and industrial research in those areas of computational engineering science and mechanics which involve and enrich the rational application of computers, numerical methods, and mechanics, in modern technology. The papers presented at this Conference cover the following topics: Solid and Structural Mechanics, Constitutive Modelling, Inelastic and Finite Deformation Response, Transient Analysis, Structural Control and Optimization, Fracture Mechanics and Structural Integrity, Computational Fluid Dynamics, Compressible and Incompressible Flow, Aerodynamics, Transport Phenomena, Heat Transfer and Solidification, Electromagnetic Field, Related Soil Mechanics and MHD, Modern Variational Methods, Biomechanics, and Off-Shore-Structural Mechanics.
Sandia is a DOE multiprogram engineering and science laboratory with major facilities at Albuquerque, New Mexico, and Livermore, California, and a test range near Tonapah, Nevada. We have major research and development responsibilities for nuclear weapons, arms control, energy, the environment, economic competitiveness, and other areas of importance to the needs of the nation. Our principal mission is to support national defense policies by ensuring that the nuclear weapon stockpile meets the highest standards of safety, reliability, security, use control, and military performance. Selected unclassified technical activities and accomplishments are reported here. Topics include advanced manufacturing technologies, intelligent machines, computational simulation, sensors and instrumentation, information management, energy and environment, and weapons technology.
Singer, Christopher E.
The National Aeronautics and Space Administration (NASA) was established in 1958, and its Marshall Space Flight Center was founded in 1960, as space-related work was transferred from the Army Ballistic Missile Agency at Redstone Arsenal, where Marshall is located. With this heritage, Marshall contributes almost 50 years of systems engineering experience with human-rated launch vehicles and scientific spacecraft to fulfill NASA's mission exploration and discovery. These complex, highly specialized systems have provided vital platforms for expanding the knowledge base about Earth, the solar system, and cosmos; developing new technologies that also benefit life on Earth; and opening new frontiers for America's strategic space goals. From Mercury and Gemini, to Apollo and the Space Shuttle, Marshall's systems engineering expertise is an unsurpassed foundational competency for NASA and the nation. Current assignments comprise managing Space Shuttle Propulsion systems; developing environmental control and life support systems and coordinating science operations on the International Space Station; and a number of exploration-related responsibilities. These include managing and performing science missions, such as the Lunar Crater Observation and Sensing Satellite and the Lunar Reconnaissance Orbiter slated to launch for the Moon in April 2009, to developing the Ares I crew launch vehicle upper stage and integrating the vehicle stack in house, as well as designing the Ares V cargo launch vehicle and contributing to the development of the Altair Lunar Lander and an International Lunar Network with communications nodes and other infrastructure.
Ao, Sio-Iong; Amouzegar, Mahyar; Rieger, Burghard
IAENG Transactions on Engineering Technologies contains forty-nine revised and extended research articles, written by prominent researchers participating in the conference. Topics covered include circuits, engineering mathematics, control theory, communications systems, systems engineering, manufacture engineering, computational biology, chemical engineering, and industrial applications. This book offers the state of art of tremendous advances in engineering technologies and physical science and applications, and also serves as an excellent source of reference for researchers and graduate students working with/on engineering technologies and physical science and applications.
Nickel, Stefan; Machado, Virgilio; Hajiyev, Asaf
This is the Proceedings of the Ninth International Conference on Management Science and Engineering Management (ICMSEM) held from July 21-23, 2015 at Karlsruhe, Germany. The goals of the conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current findings. These proceedings cover various areas in management science and engineering management. It focuses on the identification of management science problems in engineering and innovatively using management theory and methods to solve engineering problems effectively. It also establishes a new management theory and methods based on experience of new management issues in engineering. Readers interested in the fields of management science and engineering management will benefit from the latest cutting-edge innovations and research advances presented in these proceedings and will find new ideas and research directions. A total number of 132 papers from 15 countries a...
Hajiyev, Asaf; Nickel, Stefan; Gen, Mitsuo
This book presents the proceedings of the Tenth International Conference on Management Science and Engineering Management (ICMSEM2016) held from August 30 to September 02, 2016 at Baku, Azerbaijan and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Ministry of Education of Azerbaijan. The aim of conference was to foster international research collaborations in management science and engineering management as well as to provide a forum to present current research findings. The presented papers were selected and reviewed by the Program Committee, made up of respected experts in the area of management science and engineering management from around the globe. The contributions focus on identifying management science problems in engineering, innovatively using management theory and methods to solve engineering problems effectively and establishing novel management theories and methods to address new engineering management issues.
Maki, J.; Thiessen, D.; Pourangi, A.; Kobzeff, P.; Litwin, T.; Scherr, L.; Elliott, S.; Dingizian, A.; Maimone, M.
NASA's Mars Science Laboratory (MSL) Rover is equipped with a set of 12 engineering cameras. These cameras are build-to-print copies of the Mars Exploration Rover cameras described in Maki et al. (J. Geophys. Res. 108(E12): 8071, 2003). Images returned from the engineering cameras will be used to navigate the rover on the Martian surface, deploy the rover robotic arm, and ingest samples into the rover sample processing system. The Navigation cameras (Navcams) are mounted to a pan/tilt mast and have a 45-degree square field of view (FOV) with a pixel scale of 0.82 mrad/pixel. The Hazard Avoidance Cameras (Hazcams) are body-mounted to the rover chassis in the front and rear of the vehicle and have a 124-degree square FOV with a pixel scale of 2.1 mrad/pixel. All of the cameras utilize a 1024×1024 pixel detector and red/near IR bandpass filters centered at 650 nm. The MSL engineering cameras are grouped into two sets of six: one set of cameras is connected to rover computer "A" and the other set is connected to rover computer "B". The Navcams and Front Hazcams each provide similar views from either computer. The Rear Hazcams provide different views from the two computers due to the different mounting locations of the "A" and "B" Rear Hazcams. This paper provides a brief description of the engineering camera properties, the locations of the cameras on the vehicle, and camera usage for surface operations.
Capobianco, Brenda M.; Yu, Ji H.; French, Brian F.
The integration of engineering concepts and practices into elementary science education has become an emerging concern for science educators and practitioners, alike. Moreover, how children, specifically preadolescents (grades 1-5), engage in engineering design-based learning activities may help science educators and researchers learn more about…
cerevisiae. Both organisms have well-known genetic tools available for gene targeting and heterologous expression. It has been the aim to create a stable expression platform with all genes integrated in the genome. This has been achieved through the use of two advanced genetic engineering systems for A...... sufficient titers. To improve the production of polyketides biological engineering principles have been applied for the development and engineering of microbial polyketide cell factories. The two biological hosts used for heterologous polyketide production were Aspergillus nidulans and Saccharomyces....... nidulans and S. cerevisiae. Both systems have been aided by USER™ cloning vectors that were developed for efficiently generating large amounts of gene targeting substrate. Upon integration the targets should lead to high expression of the polyketide synthase (PKS) as well as the activating...
Johnson, Deborah G
It is generally thought that science and engineering should never cross certain ethical lines. The idea connects ethics to science and engineering, but it frames the relationship in a misleading way. Moral notions and practices inevitably influence and are influenced by science and engineering. The important question is how such interactions should take place. Anticipatory ethics is a new approach that integrates ethics into technological development. Copyright © 2010 Elsevier Ltd. All rights reserved.
Song, Minjung; Kim, Young-Hoon; Kim, Jin-Soo; Kim, Hyongbum
Genome editing in human cells is of great value in research, medicine, and biotechnology. Programmable nucleases including zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases recognize a specific target sequence and make a double-strand break at that site, which can result in gene disruption, gene insertion, gene correction, or chromosomal rearrangements. The target sequence complexities of these programmable nucleases are higher than 3.2 mega base pairs, the size of the haploid human genome. Here, we briefly introduce the structure of the human genome and the characteristics of each programmable nuclease, and review their applications in human cells including pluripotent stem cells. In addition, we discuss various delivery methods for nucleases, programmable nickases, and enrichment of gene-edited human cells, all of which facilitate efficient and precise genome editing in human cells.
Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science during the period April 1, 1983 through September 30, 1983 is summarized.
Kânoğlu, U; Titov, V; Bernard, E; Synolakis, C
Tsunamis are high-impact, long-duration disasters that in most cases allow for only minutes of warning before impact. Since the 2004 Boxing Day tsunami, there have been significant advancements in warning methodology, pre-disaster preparedness and basic understanding of related phenomena. Yet, the trail of destruction of the 2011 Japan tsunami, broadcast live to a stunned world audience, underscored the difficulties of implementing advances in applied hazard mitigation. We describe state of the art methodologies, standards for warnings and summarize recent advances in basic understanding, and identify cross-disciplinary challenges. The stage is set to bridge science, engineering and society to help build up coastal resilience and reduce losses. © 2015 The Author(s).
Studying hematopoietic and mesenchymal stem cells for almost three decades revealed some similarities between the stem cell entity and the single-celled eukaryotes exhibiting the anaerobic/facultative aerobic metabolic features. A careful analysis of nowadays knowledge concerning the early eukaryotic evolution allowed us to reveal some analogies between stem cells in the metazoan tissues and the single-celled eukaryotes which existed during the first phase of eukaryotes evolution in mid-Proterozoic era. In fact, it is possible to trace the principle of the self-renewal back to the first eukaryotic common ancestor, the first undifferentiated nucleated cell possessing the primitive, mostly anaerobically-respiring mitochondria and a capacity to reproduction by a simple cell division "à l'identique". Similarly, the diversification of these single-cell eukaryotes and acquiring of complex life cycle allowed/conditioned by the increase of O2 in atmosphere (and consequently in the water environment) represents a prototype for the phenomenon of commitment/differentiation. This point of view allowed to predict the ex-vivo behavior of stem cells with respect to the O2 availability and metabolic profile which enabled to conceive the successful protocols of stem cell expansion and ex vivo conditioning based on "respecting" this relationship between the anaerobiosis and stemness. In this review, the basic elements of this paradigm and a possible application in cell engineering were discussed. Copyright © 2017 Elsevier Masson SAS. All rights reserved.
Capobianco, Brenda M.; Yu, Ji H.; French, Brian F.
The integration of engineering concepts and practices into elementary science education has become an emerging concern for science educators and practitioners, alike. Moreover, how children, specifically preadolescents (grades 1-5), engage in engineering design-based learning activities may help science educators and researchers learn more about children's earliest identification with engineering. The purpose of this study was to examine the extent to which engineering identity differed among preadolescents across gender and grade, when exposing students to engineering design-based science learning activities. Five hundred fifty preadolescent participants completed the Engineering Identity Development Scale (EIDS), a recently developed measure with validity evidence that characterizes children's conceptions of engineering and potential career aspirations. Data analyses of variance among four factors (i.e., gender, grade, and group) indicated that elementary school students who engaged in the engineering design-based science learning activities demonstrated greater improvements on the EIDS subscales compared to those in the comparison group. Specifically, students in the lower grade levels showed substantial increases, while students in the higher grade levels showed decreases. Girls, regardless of grade level and participation in the engineering learning activities, showed higher scores in the academic subscale compared to boys. These findings suggest that the integration of engineering practices in the science classroom as early as grade one shows potential in fostering and sustaining student interest, participation, and self-concept in engineering and science.
Ao, Sio-Iong; Rieger, Burghard; IAENG Transactions on Engineering Technologies : Special Edition of the World Congress on Engineering and Computer Science 2011
This volume contains thirty revised and extended research articles written by prominent researchers participating in an international conference in engineering technologies and physical science and applications. The conference serves as good platforms for the engineering community to meet with each other and to exchange ideas. The conference has also struck a balance between theoretical and application development. The conference is truly international meeting with a high level of participation from many countries. Topics covered include chemical engineering, circuits, communications systems, control theory, engineering mathematics, systems engineering, manufacture engineering, and industrial applications. The book offers the state of art of tremendous advances in engineering technologies and physical science and applications, and also serves as an excellent reference work for researchers and graduate students working with/on engineering technologies and physical science and applications.
Moses, John F.; Behnke, Jeanne; Durachka, Christopher D.
At Goddard, engineers and scientists with a range of experience in science data systems are needed to employ new technologies and develop advances in capabilities for supporting new Earth and Space science research. Engineers with extensive experience in science data, software engineering and computer-information architectures are needed to lead and perform these activities. The increasing types and complexity of instrument data and emerging computer technologies coupled with the current shortage of computer engineers with backgrounds in science has led the need to develop a career path for science data systems engineers and architects.The current career path, in which undergraduate students studying various disciplines such as Computer Engineering or Physical Scientist, generally begins with serving on a development team in any of the disciplines where they can work in depth on existing Goddard data systems or serve with a specific NASA science team. There they begin to understand the data, infuse technologies, and begin to know the architectures of science data systems. From here the typical career involves peermentoring, on-the-job training or graduate level studies in analytics, computational science and applied science and mathematics. At the most senior level, engineers become subject matter experts and system architect experts, leading discipline-specific data centers and large software development projects. They are recognized as a subject matter expert in a science domain, they have project management expertise, lead standards efforts and lead international projects. A long career development remains necessary not only because of the breadth of knowledge required across physical sciences and engineering disciplines, but also because of the diversity of instrument data being developed today both by NASA and international partner agencies and because multidiscipline science and practitioner communities expect to have access to all types of observational data
Moses, J. F.; Durachka, C. D.; Behnke, J.
At Goddard, engineers and scientists with a range of experience in science data systems are needed to employ new technologies and develop advances in capabilities for supporting new Earth and Space science research. Engineers with extensive experience in science data, software engineering and computer-information architectures are needed to lead and perform these activities. The increasing types and complexity of instrument data and emerging computer technologies coupled with the current shortage of computer engineers with backgrounds in science has led the need to develop a career path for science data systems engineers and architects. The current career path, in which undergraduate students studying various disciplines such as Computer Engineering or Physical Scientist, generally begins with serving on a development team in any of the disciplines where they can work in depth on existing Goddard data systems or serve with a specific NASA science team. There they begin to understand the data, infuse technologies, and begin to know the architectures of science data systems. From here the typical career involves peer mentoring, on-the-job training or graduate level studies in analytics, computational science and applied science and mathematics. At the most senior level, engineers become subject matter experts and system architect experts, leading discipline-specific data centers and large software development projects. They are recognized as a subject matter expert in a science domain, they have project management expertise, lead standards efforts and lead international projects. A long career development remains necessary not only because of the breath of knowledge required across physical sciences and engineering disciplines, but also because of the diversity of instrument data being developed today both by NASA and international partner agencies and because multi-discipline science and practitioner communities expect to have access to all types of observational
At the request of the University Materials Council, a national workshop was convened to examine 'Gender Equity Issues in Materials Science and Engineering.' The workshop considered causes of the historic underrepresentation of women in materials science and engineering (MSE), with a goal of developing strategies to increase the gender diversity of the discipline in universities and national laboratories. Specific workshop objectives were to examine efforts to level the playing field, understand implicit biases, develop methods to minimize bias in all aspects of training and employment, and create the means to implement a broadly inclusive, family-friendly work environment in MSE departments. Held May 18-20, 2008, at the Conference Center at the University of Maryland, the workshop included heads and chairs of university MSE departments and representatives of the National Science Foundation (NSF), the Office of Basic Energy Sciences of the Department of Energy (DOE-BES), and the national laboratories. The following recommendations are made based on the outcomes of the discussions at the workshop. Many or all of these apply equally well to universities and national laboratories and should be considered in context of industrial environments as well. First, there should be a follow-up process by which the University Materials Council (UMC) reviews the status of women in the field of MSE on a periodic basis and determines what additional changes should be made to accelerate progress in gender equity. Second, all departments should strengthen documentation and enforcement of departmental procedures such that hiring, promotion, compensation, and tenure decisions are more transparent, that the reasons why a candidate was not selected or promoted are clear, and that faculty are less able to apply their biases to personnel decisions. Third, all departments should strengthen mentoring of junior faculty. Fourth, all departments must raise awareness of gender biases
Burke, Kenneth A.
Fuel cell technology has been receiving more attention recently as a possible alternative to the internal combustion engine for our automobile. Improvements in fuel cell designs as well as improvements in lightweight high-pressure gas storage tank technology make fuel cell technology worth a look to see if fuel cells can play a more expanded role in space missions. This study looks at the specific weight density and specific volume density of potential fuel cell systems as an alternative to primary and secondary batteries that have traditionally been used for space missions. This preliminary study indicates that fuel cell systems have the potential for energy densities of greater than 500 W-hr/kg, greater than 500W/kg and greater than 400 W-hr/liter, greater than 200 W/liter. This level of performance makes fuel cells attractive as high-power density, high-energy density sources for space science probes, planetary rovers and other payloads. The power requirements for these space missions are, in general, much lower than the power levels where fuel cells have been used in the past. Adaptation of fuel cells for space science missions will require down-sizing the fuel cell stack and making the fuel cell operate without significant amounts of ancillary equipment.
National Research Council Staff; Board on Science Education; Division of Behavioral and Social Sciences and Education; National Research Council; National Academy of Sciences
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Geil, Philip H.; Carr, Stephen H.
Reviews and lists introductory- to advanced-level modules (units of written materials to support a one-hour lecture on a specific topic) for materials science and engineering. Modules are available with free photocopy reproduction rights through the "Journal of Education Modules in Materials Science and Engineering." (JN)
Bernstein, Michael J; Reifschneider, Kiera; Bennett, Ira; Wetmore, Jameson M
Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. "Science Outside the Lab" is a program designed to help early-career scientists and engineers understand the complexities of science and engineering policy. Assessment of the program entailed a pre-, post-, and 1 year follow up survey to gauge student perspectives on relationships between science and society, as well as a pre-post concept map exercise to elicit student conceptualizations of science policy. Students leave Science Outside the Lab with greater humility about the role of scientific expertise in science and engineering policy; greater skepticism toward linear notions of scientific advances benefiting society; a deeper, more nuanced understanding of the actors involved in shaping science policy; and a continued appreciation of the contributions of science and engineering to society. The study presents an efficacious program that helps scientists and engineers make inroads into macroethical debates, reframe the ways in which they think about values of science and engineering in society, and more thoughtfully engage with critical mediators of science and society relationships: policy makers and policy processes.
Emerging Trends in Computing, Informatics, Systems Sciences, and Engineering includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Industrial Electronics, Technology & Automation, Telecommunications and Networking, Systems, Computing Sciences and Software Engineering, Engineering Education, Instructional Technology, Assessment, and E-learning. This book includes the proceedings of the International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering (CISSE 2010). The proceedings are a set of rigorously reviewed world-class manuscripts presenting the state of international practice in Innovative Algorithms and Techniques in Automation, Industrial Electronics and Telecommunications.
Innovations and Advances in Computer, Information, Systems Sciences, and Engineering includes the proceedings of the International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering (CISSE 2011). The contents of this book are a set of rigorously reviewed, world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Industrial Electronics, Technology and Automation, Telecommunications and Networking, Systems, Computing Sciences and Software Engineering, Engineering Education, Instructional Technology, Assessment, and E-learning.
Reviews the literature on the use of Web search engines in information science research, including: ways users interact with Web search engines; social aspects of searching; structure and dynamic nature of the Web; link analysis; other bibliometric applications; characterizing information on the Web; search engine evaluation and improvement; and…
Samara, George A.; Simmons, Jerry A.
This report presents an Executive Summary of the various elements of the Materials Sciences and Engineering Program which is funded by the Division of Materials Sciences and Engineering, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico. A general programmatic overview is also presented.
Antink-Meyer, Allison; Meyer, Daniel Z.
The aim of this exploratory study was to learn about the misconceptions that may arise for elementary and high school science teachers in their reflections on science and engineering practice. Using readings and videos of real science and engineering work, teachers' reflections were used to uncover the underpinnings of their understandings. This knowledge ultimately provides information about supporting professional development (PD) for science teachers' knowledge of engineering. Six science teachers (two elementary and four high school teachers) participated in the study as part of an online PD experience. Cunningham and Carlsen's (Journal of Science Teacher Education 25:197-210, 2014) relative emphases of science and engineering practices were used to frame the design of PD activities and the analyses of teachers' views. Analyses suggest misconceptions within the eight practices of science and engineering from the US Next Generation Science Standards in four areas. These are that: (1) the nature of the practices in both science and engineering research is determined by the long-term implications of the research regardless of the nature of the immediate work, (2) engineering and science are hierarchical, (3) creativity is inappropriate, and (4) research outcomes cannot be processes. We discuss the nature of these understandings among participants and the implications for engineering education PD for science teachers.
Lynggaard, Hans Jørgen Birk; Alting, Leo
control and monitor-ing systems for production cells. The project participants are The Danish Academy of Technical Sciences, the Institute of Manufacturing Engineering at the Technical University of Denmark and ODENSE STEEL SHIPYARD Ltd.The manufacturing environment and the current practice...... SHIPYARD.It is concluded that cell control technology provides for increased performance in production systems, and that the Cell Control Engineering concept reduces the effort for providing and operating high quality and high functionality cell control solutions for the industry....
Nunes, A. C., Jr.
This Technical Memorandum provides sample problems illustrating ways in which basic engineering science has been applied to the discipline of welding. Perhaps inferences may be drawn regarding optimal approaches to particular welding problems, as well as for the optimal education for welding engineers. Perhaps also some readers may be attracted to the science(s) of welding and may make worthwhile contributions to the discipline.
Caroline, B; Jayanthi, J
The present book is based on the research papers presented in the International Conference on Emerging Trends in Science, Engineering and Technology 2012, held at Tiruchirapalli, India. The papers presented bridges the gap between science, engineering and technology. This book covers a variety of topics, including mechanical, production, aeronautical, material science, energy, civil and environmental energy, scientific management, etc. The prime objective of the book is to fully integrate the scientific contributions from academicians, industrialists and research scholars.
Esch, Maria; Chen, Jinbo; Colmsee, Christian; Klapperstück, Matthias; Grafahrend-Belau, Eva; Scholz, Uwe; Lange, Matthias
With the number of sequenced plant genomes growing, the number of predicted genes and functional annotations is also increasing. The association between genes and phenotypic traits is currently of great interest. Unfortunately, the information available today is widely scattered over a number of different databases. Information retrieval (IR) has become an all-encompassing bioinformatics methodology for extracting knowledge from complex, heterogeneous and distributed databases, and therefore can be a useful tool for obtaining a comprehensive view of plant genomics, from genes to traits. Here we describe LAILAPS (http://lailaps.ipk-gatersleben.de), an IR system designed to link plant genomic data in the context of phenotypic attributes for a detailed forward genetic research. LAILAPS comprises around 65 million indexed documents, encompassing >13 major life science databases with around 80 million links to plant genomic resources. The LAILAPS search engine allows fuzzy querying for candidate genes linked to specific traits over a loosely integrated system of indexed and interlinked genome databases. Query assistance and an evidence-based annotation system enable time-efficient and comprehensive information retrieval. An artificial neural network incorporating user feedback and behavior tracking allows relevance sorting of results. We fully describe LAILAPS's functionality and capabilities by comparing this system's performance with other widely used systems and by reporting both a validation in maize and a knowledge discovery use-case focusing on candidate genes in barley. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists.
Science and engineering are built on trust. C.P. Snow's famous quote, "the only ethical principle which has made science possible is that the truth shall be told all the time" underscores the importance of honesty in science. Environmental scientists must do work that is useful...
Hill, Catherine; Corbett, Christianne; St. Rose, Andresse
The number of women in science and engineering is growing, yet men continue to outnumber women, especially at the upper levels of these professions. In elementary, middle, and high school, girls and boys take math and science courses in roughly equal numbers, and about as many girls as boys leave high school prepared to pursue science and…
Taylor, Travis S
What Are Rockets? The History of RocketsRockets of the Modern EraRocket Anatomy and NomenclatureWhy Are Rockets Needed? Missions and PayloadsTrajectoriesOrbitsOrbit Changes and ManeuversBallistic Missile TrajectoriesHow Do Rockets Work? ThrustSpecific ImpulseWeight Flow RateTsiolkovsky's Rocket EquationStagingRocket Dynamics, Guidance, and ControlHow Do Rocket Engines Work? The Basic Rocket EngineThermodynamic Expansion and the Rocket NozzleExit VelocityRocket Engine Area Ratio and LengthsRocket Engine Design ExampleAre All Rockets the Same? Solid Rocket EnginesLiquid Propellant Rocket Engines
G. P. Litvintseva
Full Text Available Introduction. Achievements in various fields of modern science have an impact not only on the development of science itself, but also on the formation of human capital, including training of technical personnel needed for the transition to an information society.The aim of the article is to show interinfluence of different sciences of engineering staff training and specific aspects of their training in modern conditions.Methodology and research methods. The research is based on the system-based approach, experimental knowledge generalization, comparative analysis and economics methodology. We used analysis of national and foreign literature, official documents and statistic data of the Russian Federation, Global Competitiveness Index. Also, information processing was carried out using graphic methods.Results. The influence of natural sciences on economic knowledge development as well as on perfection of engineering and engineering education is shown. Decrease in researcher numbers as well as lack of young people in engineering sciences is revealed. In particular, the following disturbing facts are established and emphasized: engineers are a fifth part among graduates and this share has been nearly constant during the last 10 years. However, the number of engineering specialists going abroad for work continues to grow.Scientific novelty. The conclusions on the influence of natural sciences on economic theory development as well applied economics on engineering development are made. Special aspects of modern engineers training as knowledge integrator are highlighted.Practical significance. Based on the analysis of official statistics, data the trend of engineering specialists decrease in Russia is shown. In connection with engineering staff aging and low number of engineering companies, the necessity for new engineering model implementation and new type of engineers training is emphasized.
Mercer-smith, Janet A [Los Alamos National Laboratory; Wallace, Terry C [Los Alamos National Laboratory
The Laboratory provides science solution to the mission areas of nuclear deterrence, global security, and energy security. The capabilities support the Laboratory's vision as the premier national security science laboratory. The strength of LANL's science is at the core of the Laboratory. The Laboratory addresses important science questions for stockpile stewardship, emerging threats, and energy. The underpinning science vitality to support mission areas is supported through the Post Doc program, the fundamental science program in LDRD, collaborations fostered through the Institutes, and the LANL user facilities. LANL fosters the strategy of Science that Matters through investments, people, and facilities.
Bulucea, Aida; Tsekouras, George
This book provides readers with modern computational techniques for solving variety of problems from electrical, mechanical, civil and chemical engineering. Mathematical methods are presented in a unified manner, so they can be applied consistently to problems in applied electromagnetics, strength of materials, fluid mechanics, heat and mass transfer, environmental engineering, biomedical engineering, signal processing, automatic control and more.
... science, technology, engineering, or mathematics (STEM) fields; or applications that develop articulation... in science, technology, engineering and mathematics. D. For cooperative projects grants, eligible... the fields of engineering or physical or biological sciences, compared to the average minority...
Min, Tae-Sun; Han, Jin; Kim, Seong-Yong; Rhee, Byoung-Doo; Kim, Myung-Suk
This study examined ways of promoting research in the medical sciences by evaluating trends in research funding, and the present status of research funding by the Korea Science and Engineering Foundation (KOSEF...
This book draws together the most interesting recent results to emerge in mechanical engineering in Russia, providing a fascinating overview of the state of the art in the field in that country which will be of interest to a wide readership. A broad range of topics and issues in modern engineering are discussed, including dynamics of machines, materials engineering, structural strength and tribological behavior, transport technologies, machinery quality and innovations. The book comprises selected papers presented at the conference "Modern Engineering: Science and Education", held at the Saint Petersburg State Polytechnic University in 2013 with the support of the Russian Engineering Union. The authors are experts in various fields of engineering, and all of the papers have been carefully reviewed. The book will be of interest to mechanical engineers, lecturers in engineering disciplines, and engineering graduates.
Lucking, Robert A.; Christmann, Edwin P.; Wighting, Mervyn J.
Although in some schools cell phones have to be turned off or perhaps kept in lockers to avoid misuse, the authors hope to demonstrate in this article how they can be used under supervision to assist learning. This ubiquitous device can be a powerful classroom tool. (Contains 2 figures.)
... Advisory Committee for Computer and Information; Science and Engineering; Notice of Meeting In accordance... announces the following meeting: ] Name: Advisory Committee for Computer and Information Science and..., Directorate for Computer and Information, Science and Engineering, National Science Foundation, 4201 Wilson...
... FOUNDATION Advisory Committee for Computer and Information Science And Engineering; Notice of Meeting In... Foundation announces the following meeting: Name: Advisory Committee for Computer and Information Science and...: Carmen Whitson, Directorate for Computer and Information Science and Engineering, National Science...
Fry, John; Lev, Benjamin; Hajiyev, Asaf; Vol.I Focused on Electrical and Information Technology; Vol.II Focused on Electrical and Information Technology
This book presents the proceedings of the Seventh International Conference on Management Science and Engineering Management (ICMSEM2013) held from November 7 to 9, 2013 at Drexel University, Philadelphia, Pennsylvania, USA and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Drexel University (Philadelphia, Pennsylvania, USA). The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research findings. The selected papers cover various areas in management science and engineering management, such as Decision Support Systems, Multi-Objective Decisions, Uncertain Decisions, Computational Mathematics, Information Systems, Logistics and Supply Chain Management, Relationship Management, Scheduling and Control, Data Warehousing and Data Mining, Electronic Commerce, Neural Networks, Stochastic Models and Simulation, F...
Panel on Communicating National Science Foundation Science and Engineering Information to Data Users; National Research Council
...) communicates its science and engineering (S&E) information to data users in a very fluid environment that is undergoing modernization at a pace at which data producer dissemination practices, protocols, and technologies, on one hand, and user...
Cruz-Machado, Virgílio; Lev, Benjamin; Nickel, Stefan
This is the Proceedings of the Eighth International Conference on Management Science and Engineering Management (ICMSEM) held from July 25 to 27, 2014 at Universidade Nova de Lisboa, Lisbon, Portugal and organized by International Society of Management Science and Engineering Management (ISMSEM), Sichuan University (Chengdu, China) and Universidade Nova de Lisboa (Lisbon, Portugal). The goals of the conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current findings. A total number of 138 papers from 14 countries are selected for the proceedings by the conference scientific committee through rigorous referee review. The selected papers in the second volume are focused on Computing and Engineering Management covering areas of Computing Methodology, Project Management, Industrial Engineering and Information Technology.
Narayanan, Karthikeyan; Mishra, Sachin; Singh, Satnam; Pei, Ming; Gulyas, Balazs; Padmanabhan, Parasuraman
The field of regenerative medicine integrates advancements made in stem cells, molecular biology, engineering, and clinical methodologies. Stem cells serve as a fundamental ingredient for therapeutic application in regenerative medicine. Apart from stem cells, engineering concepts have equally contributed to the success of stem cell based applications in improving human health. The purpose of various engineering methodologies is to develop regenerative and preventive medicine to combat various diseases and deformities. Explosion of stem cell discoveries and their implementation in clinical setting warrants new engineering concepts and new biomaterials. Biomaterials, microfluidics, and nanotechnology are the major engineering concepts used for the implementation of stem cells in regenerative medicine. Many of these engineering technologies target the specific niche of the cell for better functional capability. Controlling the niche is the key for various developmental activities leading to organogenesis and tissue homeostasis. Biomimetic understanding not only helped to improve the design of the matrices or scaffolds by incorporating suitable biological and physical components, but also ultimately aided adoption of designs that helped these materials/devices have better function. Adoption of engineering concepts in stem cell research improved overall achievement, however, several important issues such as long-term effects with respect to systems biology needs to be addressed. Here, in this review the authors will highlight some interesting breakthroughs in stem cell biology that use engineering methodologies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Wu, Chia-Yung; Rupp, Levi J; Roybal, Kole T; Lim, Wendell A
There is rapidly growing interest in learning how to engineer immune cells, such as T lymphocytes, because of the potential of these engineered cells to be used for therapeutic applications such as the recognition and killing of cancer cells. At the same time, our knowhow and capability to logically engineer cellular behavior is growing rapidly with the development of synthetic biology. Here we describe how synthetic biology approaches are being used to rationally alter the behavior of T cells to optimize them for therapeutic functions. We also describe future developments that will be important in order to construct safe and precise T cell therapeutics. Copyright © 2015 Elsevier Ltd. All rights reserved.
Ivey, Elizabeth S.
The number of women faculty members in engineering correlates directly with the number of women who pursue careers in this field. Proposed are ways to break the cycle of too few role models producing another generation of too few women engineers. (CW)
Batcheller, Archer L.
Software has an important role in supporting scientific work. This dissertation studies teams that build scientific software, focusing on the way that they determine what the software should do. These requirements engineering processes are investigated through three case studies of climate science software projects. The Earth System Modeling Framework assists modeling applications, the Earth System Grid distributes data via a web portal, and the NCAR (National Center for Atmospheric Research) Command Language is used to convert, analyze and visualize data. Document analysis, observation, and interviews were used to investigate the requirements-related work. The first research question is about how and why stakeholders engage in a project, and what they do for the project. Two key findings arise. First, user counts are a vital measure of project success, which makes adoption important and makes counting tricky and political. Second, despite the importance of quantities of users, a few particular "power users" develop a relationship with the software developers and play a special role in providing feedback to the software team and integrating the system into user practice. The second research question focuses on how project objectives are articulated and how they are put into practice. The team seeks to both build a software system according to product requirements but also to conduct their work according to process requirements such as user support. Support provides essential communication between users and developers that assists with refining and identifying requirements for the software. It also helps users to learn and apply the software to their real needs. User support is a vital activity for scientific software teams aspiring to create infrastructure. The third research question is about how change in scientific practice and knowledge leads to changes in the software, and vice versa. The "thickness" of a layer of software infrastructure impacts whether the
Constanda, C; Rollins, D
Presents a series of analytic and numerical methods of solution constructed for important problems arising in science and engineering, based on the powerful operation of integration. This volume is meant for researchers and practitioners in applied mathematics, physics, and mechanical and electrical engineering, as well as graduate students.
People have different learning styles that are reflected in different academic strengths, weaknesses, skills, and interests. Given the almost unlimited variety of job descriptions within food science and engineering, it is safe to say that students with every possible learning style have the potential to succeed as food scientists and engineers.…
Turner, Ken L., Jr.; Hoffman, Adam R.
Engineering design is an ideal perspective for engaging students in college science classes. An engineering design problem-solving framework was used to create a general chemistry lab activity focused on an important environmental issue--dead zones. Dead zones impact over 400 locations around the world and are a result of nutrient pollution, one…
Akashi, Misturu; Matsusaki, Michiya
This book is the first to summarize new technologies for engineered cell manipulation. The contents focus on control of cellular functions by nanomaterials and control of three-dimensional cell-cell interactions. Control of cellular functions is important for cell differentiation, maturation, and activation, which generally are controlled by the addition of soluble cytokines or growth factors into cell culture dishes. Target antigen molecules can be efficiently delivered to the cytosol of the dendritic cells using the nanoparticle technique described here, and cellular functions such as dendritic cell maturation can be controlled easily and with precision. This book describes basic preparation of the nanoparticles, activation control of dendritic cells, immune function control, and in vivo application for various vaccination systems. The second type of control,that of cell-cell interaction, is important for tissue engineering in order to develop three-dimensional cellular constructs. To achieve in vitro engin...
Zizka, Jan; Nagamalai, Dhinaharan
The International conference series on Computer Science, Engineering & Applications (ICCSEA) aims to bring together researchers and practitioners from academia and industry to focus on understanding computer science, engineering and applications and to establish new collaborations in these areas. The Second International Conference on Computer Science, Engineering & Applications (ICCSEA-2012), held in Delhi, India, during May 25-27, 2012 attracted many local and international delegates, presenting a balanced mixture of intellect and research both from the East and from the West. Upon a strenuous peer-review process the best submissions were selected leading to an exciting, rich and a high quality technical conference program, which featured high-impact presentations in the latest developments of various areas of computer science, engineering and applications research.
Zizka, Jan; Nagamalai, Dhinaharan
The International conference series on Computer Science, Engineering & Applications (ICCSEA) aims to bring together researchers and practitioners from academia and industry to focus on understanding computer science, engineering and applications and to establish new collaborations in these areas. The Second International Conference on Computer Science, Engineering & Applications (ICCSEA-2012), held in Delhi, India, during May 25-27, 2012 attracted many local and international delegates, presenting a balanced mixture of intellect and research both from the East and from the West. Upon a strenuous peer-review process the best submissions were selected leading to an exciting, rich and a high quality technical conference program, which featured high-impact presentations in the latest developments of various areas of computer science, engineering and applications research.
Glasgow, Larry A
Prepare students for success in using applied mathematics for engineering practice and post-graduate studies moves from one mathematical method to the next sustaining reader interest and easing the application of the techniques Uses different examples from chemical, civil, mechanical and various other engineering fields Based on a decade's worth of the authors lecture notes detailing the topic of applied mathematics for scientists and engineers Concisely writing with numerous examples provided including historical perspectives as well as a solutions manual for academic adopters
Rosser, Sue V.
Fiscal year 2001 marked an important milestone in policies to attract and retain women in science and engineering. That year, the National Science Foundation (NSF) initiated an awards program called ADVANCE at a funding level of $19 million. The program supports efforts by institutions and individuals to empower women to participate fully in…
Lin, Kuen-Yi; Williams, P. John
This study applies the theory of planned behavior as a basis for exploring the impact of knowledge, values, subjective norms, perceived behavioral controls, and attitudes on the behavioral intention toward science, technology, engineering, and mathematics (STEM) education among Taiwanese preservice science teachers. Questionnaires (N = 139)…
Yin, Perry T.; Han, Edward
Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recently, efforts have focused on engineering stem cells in order to further enhance their innate abilities as well as to confer them with new functionalities, which can then be used in various biomedical applications. These engineered stem cells can take on a number of forms. For instance, engineered stem cells encompass the genetic modification of stem cells as well as the use of stem cells for gene delivery, nanoparticle loading and delivery, and even small molecule drug delivery. The present Review gives an in-depth account of the current status of engineered stem cells, including potential cell sources, the most common methods used to engineer stem cells, and the utilization of engineered stem cells in various biomedical applications, with a particular focus on tissue regeneration, the treatment of immunodeficiency diseases, and cancer. PMID:25772134
Usman, Juliana; Mohktar, Mas; Ahmad, Mohd
This volumes presents the proceedings of ICIBEL 2015, organized by the Centre for Innovation in Medical Engineering (CIME) under Innovative Technology Research Cluster, University of Malaya. It was held in Kuala Lumpur, Malaysia, from 6-8 December 2015. The ICIBEL 2015 conference promotes the latest researches and developments related to the integration of the Engineering technology in medical fields and life sciences. This includes the latest innovations, research trends and concerns, challenges and adopted solution in the field of medical engineering and life sciences. .
Full Text Available In this work are collected years of experience and the work of systems engineering, and debates centered in the industry leadership, of engineer and instructors around the world. A recurrent issue in this experiences and discussions is that community used a lot of terms and titles more diffused with the aim of achieve an agreement toward a common comprehension of this area of knowledge. Besides, it does not matter how are divided the functions and responsibilities among teams, the obligatoriness is ensure that this be clears and are run as a functional whole. The goal is provide a wide definition of systems engineer, described the characteristics of behave of highly effective engineered, and make explicit the expectations of the same.
National Aeronautics and Space Administration — This data set is composed of data produced during the descent to Titan on January 14 2005 from the ACP instrument (Engineering data) and also from the GCMS...
Minai, Ali A; Bar-Yam, Yaneer
Every time that we take money out of an ATM, surf the internet or simply turn on a light switch, we enjoy the benefits of complex engineered systems. Systems like power grids and global communication networks are so ubiquitous in our daily lives that we usually take them for granted, only noticing them when they break down. But how do such amazing technologies and infrastructures come to be what they are? How are these systems designed? How do distributed networks work? How are they made to respond rapidly in 'real time'? And as the demands that we place on these systems become increasingly complex, are traditional systems-engineering practices still relevant? This volume examines the difficulties that arise in creating highly complex engineered systems and new approaches that are being adopted. Topics addressed range from the formal representation and classification of distributed networked systems to revolutionary engineering practices inspired by biological evolution. By bringing together the latest resear...
Schnittka, Christine G.
The purpose of this research was to investigate the impact of engineering design classroom activities on conceptual change in science, and on attitudes toward and knowledge about engineering. Students were given a situated learning context and a rationale for learning science in an active, inquiry-based method, and worked in small collaborative groups. One eighth-grade physical science teacher and her students participated in a unit on heat transfer and thermal energy. One class served as the control while two others received variations of an engineering design treatment. Data were gathered from teacher and student entrance and exit interviews, audio recordings of student dialog during group work, video recordings and observations of all classes, pre- and posttests on science content and engineering attitudes, and artifacts and all assignments completed by students. Qualitative and quantitative data were collected concurrently, but analysis took place in two phases. Qualitative data were analyzed in an ongoing manner so that the researcher could explore emerging theories and trends as the study progressed. These results were compared to and combined with the results of the quantitative data analysis. Analysis of the data was carried out in the interpretive framework of analytic induction. Findings indicated that students overwhelmingly possessed alternative conceptions about heat transfer, thermal energy, and engineering prior to the interventions. While all three classes made statistically significant gains in their knowledge about heat and energy, students in the engineering design class with the targeted demonstrations made the most significant gains over the other two other classes. Engineering attitudes changed significantly in the two classes that received the engineering design intervention. Implications from this study can inform teachers' use of engineering design activities in science classrooms. These implications are: (1) Alternative conceptions will
Xiao, Su; Shiloach, Joseph; Betenbaugh, Michael J
Cellular engineering of bacteria, fungi, insect cells and mammalian cells is a promising methodology to improve recombinant protein production for structural, biochemical, and commercial applications. Increased understanding of the host organism biology has suggested engineering strategies targeting bottlenecks in transcription, translation, protein processing and secretory pathways, as well as cell growth and survival. A combination of metabolic engineering and synthetic biology has been used to improve the properties of cells for protein production, which has resulted in enhanced yields of multiple protein classes. Copyright © 2014 Elsevier Ltd. All rights reserved.
Cruz-Machado, Virgílio; Lev, Benjamin; Nickel, Stefan
This is the Proceedings of the Eighth International Conference on Management Science and Engineering Management (ICMSEM) held from July 25 to 27, 2014 at Universidade Nova de Lisboa, Lisbon, Portugal and organized by International Society of Management Science and Engineering Management (ISMSEM), Sichuan University (Chengdu, China) and Universidade Nova de Lisboa (Lisbon, Portugal). The goals of the conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current findings. A total number of 138 papers from 14 countries are selected for the proceedings by the conference scientific committee through rigorous referee review. The selected papers in the first volume are focused on Intelligent System and Management Science covering areas of Intelligent Systems, Decision Support Systems, Manufacturing and Supply Chain Management.
Stieb, James A
Authors such as Krishnasamy Selvan argue that "all human endeavors including engineering and science" have a single primary objective: "bettering humanity." They favor discussing "the history of science and measurement uncertainty." This paper respectfully disagrees and argues that "human endeavors including engineering and science" should not pursue "bettering humanity" as their primary objective. Instead these efforts should first pursue individual betterment. One cannot better humanity without knowing what that means. However, there is no one unified theory of what is to the betterment of humanity. Simultaneously, there is no one field (neither science, nor engineering, nor philosophy) entitled to rule univocally. Perhaps if theorists tended their own gardens, the common weal would be tended thereby.
Lesko, Kevin T; Alonso, Jose; Bauer, Paul; Chan, Yuen-Dat; Chinowsky, William; Dangermond, Steve; Detwiler, Jason A; De Vries, Syd; DiGennaro, Richard; Exter, Elizabeth; Fernandez, Felix B; Freer, Elizabeth L; Gilchriese, Murdock G D; Goldschmidt, Azriel; Grammann, Ben; Griffing, William; Harlan, Bill; Haxton, Wick C; Headley, Michael; Heise, Jaret; Hladysz, Zbigniew; Jacobs, Dianna; Johnson, Michael; Kadel, Richard; Kaufman, Robert; King, Greg; Lanou, Robert; Lemut, Alberto; Ligeti, Zoltan; Marks, Steve; Martin, Ryan D; Matthesen, John; Matthew, Brendan; Matthews, Warren; McConnell, Randall; McElroy, William; Meyer, Deborah; Norris, Margaret; Plate, David; Robinson, Kem E; Roggenthen, William; Salve, Rohit; Sayler, Ben; Scheetz, John; Tarpinian, Jim; Taylor, David; Vardiman, David; Wheeler, Ron; Willhite, Joshua; Yeck, James
The DUSEL Project has produced the Preliminary Design of the Deep Underground Science and Engineering Laboratory (DUSEL) at the rehabilitated former Homestake mine in South Dakota. The Facility design calls for, on the surface, two new buildings - one a visitor and education center, the other an experiment assembly hall - and multiple repurposed existing buildings. To support underground research activities, the design includes two laboratory modules and additional spaces at a level 4,850 feet underground for physics, biology, engineering, and Earth science experiments. On the same level, the design includes a Department of Energy-shepherded Large Cavity supporting the Long Baseline Neutrino Experiment. At the 7,400-feet level, the design incorporates one laboratory module and additional spaces for physics and Earth science efforts. With input from some 25 science and engineering collaborations, the Project has designed critical experimental space and infrastructure needs, including space for a suite of multi...
National Science Foundation, Arlington, VA.
This report is based on a study conducted by the National Science Board (NSB) and informs the national dialogue on the current state and future direction of the science and engineering (S&E) infrastructure. It highlights the role of the National Science Foundation (NSF) as well as the larger resource and management strategies of interest to…
Jansma, P. A.
There has been much discussion of late in the NASA systems engineering community about the fact that systems engineering cannot be just about process and technical disciplines. The belief is that there is both an art and science to systems engineering, and that both aspects are necessary for designing and implementing a successful system or mission. How does one go about differentiating between and characterizing these two aspects? Some say that the art of systems engineering is about designing systems that not only function well, but that are also elegant, beautiful and engaging. What does that mean? How can you tell when a system has been designed with that holistic "art" component? This paper attempts to answer these questions by exploring various ways of looking at the Art and Science of Systems Engineering.
Full Text Available The product of the engineering thinking and creation, using spatial imagination, spatial situations analysis and synthesis, combines the engineering “art” with an own “language” of communication. This language, “the graphic language” is a universal one and existed from ancient times. Engineering education is based on this language of communication, that’s why GRAPHIC SCIENCE is the most important subject of the first year in superior technical studies. The idea and rules of “Bologna” system affected very much the equilibrium of different subjects in engineering education.
to prove that piston- engine construction was in its decline and gas turbines would be the engines of the future. Probably at a time when unspoken...the long known. The main thing is to know how to formulate the problem." 94 "Well, Yuriy Sergeyevich, how do you intend to overcome Archimedes ’ law...support. It exists in and of itself. It stood in a wind of 40 m/s, and there have been no storms that have carried it away. The home’s system is
Catherine M Koehler; Elias Faraclas; David Giblin; David M Moss; Kazem Kazerounian
This study explores how engineering concepts are represented in secondary science standards across the nation by examining how engineering and technical concepts are infused into these frameworks...
Seong, Jeong Min [Department of Preventive and Social Dentistry and Institute of Oral Biology, College of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Kim, Byung-Chul; Park, Jae-Hong; Kwon, Il Keun; Hwang, Yu-Shik [Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, College of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Mantalaris, Anathathios, E-mail: email@example.com [Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ (United Kingdom)
Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cells (MDSCs) and dental pulp stem cells (DPSCs) have received extensive attention in the field of bone tissue engineering due to their distinct biological capability to differentiate into osteogenic lineages. The application of these stem cells to bone tissue engineering requires inducing in vitro differentiation of these cells into bone forming cells, osteoblasts. For this purpose, efficient in vitro differentiation towards osteogenic lineage requires the development of well-defined and proficient protocols. This would reduce the likelihood of spontaneous differentiation into divergent lineages and increase the available cell source for application to bone tissue engineering therapies. This review provides a critical examination of the various experimental strategies that could be used to direct the differentiation of ESC, BM-MSC, UCB-MSC, ADSC, MDSC and DPSC towards osteogenic lineages and their potential applications in tissue engineering, particularly in the regeneration of bone. (topical review)
Elvina Santoso, Shelvy; Hardianto, Ekky
Preface: International Conference of Applied Science and Technology for Infrastructure Engineering (ICASIE) 2017. The International Conference of Applied Science and Technology for Infrastructure Engineering (ICASIE) 2017 has been scheduled and successfully taken place at Swiss-Bell Inn Hotel, Surabaya, Indonesia, on August 5th 2017 organized by Department of Civil Infrastructure Engineering, Faculty of Vocation, Institut Teknologi Sepuluh Nopember (ITS). This annual event aims to create synergies between government, private sectors; employers; practitioners; and academics. This conference has different theme each year and “MATERIAL FOR INFRASTUCTURE ENGINEERING” will be taken for this year’s main theme. In addition, we also provide a platform for various other sub-theme topic including but not limited to Geopolymer Concrete and Materials Technology, Structural Dynamics, Engineering, and Sustainability, Seismic Design and Control of Structural Vibrations, Innovative and Green Buildings, Project Management, Transportation and Highway Engineering, Geotechnical Engineering, Water Engineering and Resources Management, Surveying and Geospatial Engineering, Coastal Engineering, Geophysics, Energy, Electronic and Mechatronic, Industrial Process, and Data Mining. List of Organizers, Journal Editors, Steering Committee, International Scientific Committee, Chairman, Keynote Speakers are available in this pdf.
Reactions and Reaction Engineering (eds R A Mashelkar, R Kumar) ... eighteen portraits of some major frontiers of research in CRE by a Micro-Who's Who of contemporary CRE researchers... good mix of theory and experiment that will provide many a good read for the specialist as well as the generalist researcher.
Brandon, N P; Brett, D J
Porous materials play an important role in fuel cell engineering. For example, they are used to support delicate electrolyte membranes, where mechanical integrity and effective diffusivity to fuel gases is critical; they are used as gas diffusion layers, where electronic conductivity and permeability to both gas and water is critical; and they are used to construct fuel cell electrodes, where an optimum combination of ionic conductivity, electronic conductivity, porosity and catalyst distribution is critical. The paper will discuss these characteristics, and introduce the materials and processing methods used to engineer porous materials within two of the leading fuel cell variants, the solid oxide fuel cell and the polymer electrolyte membrane fuel cell.
Loring, Jeanne; McDevitt, Todd; Palecek, Sean; Schaffer, David; Zandstra, Peter
This book describes a global assessment of stem cell engineering research, achieved through site visits by a panel of experts to leading institutes, followed by dedicated workshops. The assessment made clear that engineers and the engineering approach with its quantitative, system-based thinking can contribute much to the progress of stem cell research and development. The increased need for complex computational models and new, innovative technologies, such as high-throughput screening techniques, organ-on-a-chip models and in vitro tumor models require an increasing involvement of engineers and physical scientists. Additionally, this book will show that although the US is still in a leadership position in stem cell engineering, Asian countries such as Japan, China and Korea, as well as European countries like the UK, Germany, Sweden and the Netherlands are rapidly expanding their investments in the field. Strategic partnerships between countries could lead to major advances of the field and scalable expansi...
Gathering 20 chapters contributed by respected experts, this book reports on the latest advances in and applications of sliding mode control in science and engineering. The respective chapters address applications of sliding mode control in the broad areas of chaos theory, robotics, electrical engineering, physics, chemical engineering, memristors, mechanical engineering, environmental engineering, finance, and biology. Special emphasis has been given to papers that offer practical solutions, and which examine design and modeling involving new types of sliding mode control such as higher order sliding mode control, terminal sliding mode control, super-twisting sliding mode control, and integral sliding mode control. This book serves as a unique reference guide to sliding mode control and its recent applications for graduate students and researchers with a basic knowledge of electrical and control systems engineering.
Solar energy is available all over the world in different intensities. Theoretically, the solar energy available on the surface of the earth is enough to support the energy requirements of the entire planet. However, in reality, progress and development of solar science and technology depends to a large extent on human desires and needs. This is due to the various barriers to overcome and to deal with the economics of practical utilization of solar energy.This book will introduce the rapid development and progress in the field of solar energy applications for science and technology: the advanc
These programs, partly funded by Mexico's Consejo Nacional de Ciencia y Tecnologia (CONACYT) (National council of science and technology), have considerably improved the participation of indigenous people in the country's education system. However, there continue to be important challenges in advancement ...
Michel, George F
Forty years ago, Lehrman (1971) identified 2 orientations to the study of animal behavior. The natural history orientation conducted field and lab research designed to reveal how animals cope with the circumstances of their natural environment. Such research reveals the diversity among different types of animals and differences between the world of animals and the world of humans (i.e., "poetry"). In contrast, the anthropocentric orientation studies animals either to generate animal-derived general laws applicable to humans or to provide experimental information that, for ethical and practical reasons, cannot be acquired from human research. The primary motivation for the anthropocentric orientation is to provide workable models for investigating specifically human problems (i.e., "engineering"). Evidence is presented from the study of bird song that demonstrates the contribution that the "poetic" approach can make to anthropocentric ("engineering") concerns. 2010 APA, all rights reserved
In this book, Sanjoy Mahajan shows us that the way to master complexity is through insight rather than precision. Precision can overwhelm us with information, whereas insight connects seemingly disparate pieces of information into a simple picture. Unlike computers, humans depend on insight. Based on the author's fifteen years of teaching at MIT, Cambridge University, and Olin College, The Art of Insight in Science and Engineering shows us how to build insight and find understanding, giving readers tools to help them solve any problem in science and engineering. To master complexity, we can organize it or discard it. The Art of Insight in Science and Engineering first teaches the tools for organizing complexity, then distinguishes the two paths for discarding complexity: with and without loss of information. Questions and problems throughout the text help readers master and apply these groups of tools. Armed with this three-part toolchest, and without complicated mathematics, readers can estimate the flight ...
Falconer, Etta Z.; Guy, Lori Ann
The Women in Science and Engineering Scholars Program provides scientifically talented women students, including those from groups underrepresented in the scientific and technical work force, with the opportunity to pursue undergraduate studies in science and engineering in the highly motivating and supportive environment of Spelman College. It also exposes students to research training at NASA Centers during the summer. The program provides an opportunity for students to increase their knowledge of career opportunities at NASA and to strengthen their motivation through exposure to NASA women scientists and engineers as role models. An extensive counseling and academic support component to maximize academic performance supplements the instructional and research components. The program is designed to increase the number of women scientists and engineers with graduate degrees, particularly those with an interest in a career with NASA.
Camp, W.J.; Plimpton, S.J.
MIMD massively parallel computers promise unique power and flexibility for engineering and scientific simulations. In this paper we review the development of a number of software methods and algorithms for scientific and engineering problems which are helping to realize that promise. We discuss new domain decomposition, load balancing, data layout and communications methods applicable to simulations in a broad range of technical field including signal processing, multi-dimensional structural and fluid mechanics, materials science, and chemical and biological systems.
Vijaya, M S
Piezoelectric Materials and Devices: Applications in Engineering and Medical Sciences provides a complete overview of piezoelectric materials, covering all aspects of the materials starting from fundamental concepts. The treatment includes physics of piezoelectric materials, their characteristics and applications. The author uses simple language to explain the theory of piezoelectricity and introduce readers to the properties and design of different types of piezoelectric materials, such as those used in engineering and medical device applications.This book: Introduces various types of dielect
Rosenkrantz, Walter A
Data Analysis Orientation The Role and Scope of Statistics in Science and Engineering Types of Data: Examples from Engineering, Public Health, and Finance The Frequency Distribution of a Variable Defined on a Population Quantiles of a Distribution Measures of Location (Central Value) and Variability Covariance, Correlation, and Regression: Computing a Stock's Beta Mathematical Details and Derivations Large Data Sets Probability Theory Orientation Sample Space, Events, Axioms of Probability Theory Mathematical Models of Random Sampling Conditional Probability and Baye
Robert W. Lingard
To be successful in today's workplace, engineering and computer science students must possess high levels of teamwork skills. Unfortunately, most engineering programs provide little or no specific instruction in this area. This paper outlines an assessment-driven approach toward teaching teamwork skills. Working with the Industrial Advisory Board for the College, a set of performance criteria for teamwork was developed. This set of criteria was used to build an assessment instrument to measur...
This report contains extended abstracts that summarize presentations made at the Workshop on Applications of Synchrotron Radiation to Chemical Engineering Science held at Argonne National Laboratory (ANL), Argonne, IL, on April 22--23, 1991. The talks emphasized the application of techniques involving absorption fluorescence, diffraction, and reflection of synchrotron x-rays, with a focus on problems in applied chemistry and chemical engineering, as well as on the use of x-rays in topographic, tomographic, and lithographic procedures. The attendees at the workshop included experts in the field of synchrotron science, scientists and engineers from ANL, other national laboratories, industry, and universities; and graduate and undergraduate students who were enrolled in ANL educational programs at the time of the workshop. Talks in the Plenary and Overview Session described the status of and special capabilities to be offered by the Advanced Photon Source (APS), as well as strategies and opportunities for utilization of synchrotron radiation to solve science and engineering problems. Invited talks given in subsequent sessions covered the use of intense infrared, ultraviolet, and x-ray photon beams (as provided by synchrotrons) in traditional and nontraditional areas of chemical engineering research related to electrochemical and corrosion science, catalyst development and characterization, lithography and imaging techniques, and microanalysis.
The Lawrence Livermore National Laboratory and four major Historically Black Colleges and Universities with strong research and development capabilities in science, engineering and computer technology have formed the Science and Engineering Alliance. Located in California, Alabama, Mississippi, Louisiana and Texas, each brings to the Alliance a tradition of research and development and educational excellence. This unique consortium is now available to perform research development and training to meet the needs of the public and private sectors. The Alliance was formed to help assure an adequate supply of top-quality minority scientists in the next century, while simultaneously meeting the research and development needs of the public and private sectors.
Gonzalez, Teofilo; Tucker, Allen
Overview of Computer Science Structure and Organization of Computing Peter J. DenningComputational Thinking Valerie BarrAlgorithms and Complexity Data Structures Mark WeissBasic Techniques for Design and Analysis of Algorithms Edward ReingoldGraph and Network Algorithms Samir Khuller and Balaji RaghavachariComputational Geometry Marc van KreveldComplexity Theory Eric Allender, Michael Loui, and Kenneth ReganFormal Models and Computability Tao Jiang, Ming Li, and Bala
Stem cells are the building blocks for all other cells in an organism. The human body has about 200 different types of cells and any of those cells can be produced by a stem cell. This fact emphasizes the significance of stem cells in transplantational medicine, regenerative therapy and bioengineering. Whether embryonic or adult, these cells can be used for the successful treatment of a wide range of diseases that were not treatable before, such as osteogenesis imperfecta in children, different forms of leukemias, acute myocardial infarction, some neural damages and diseases, etc. Bioengineering, e.g. successful manipulation of these cells with multipotential capacity of differentiation toward appropriate patterns and precise quantity, are the prerequisites for successful outcome and treatment. By combining in vivo and in vitro techniques, it is now possible to manage the wide spectrum of tissue damages and organ diseases. Although the stem-cell therapy is not a response to all the questions, it provides more...
Kerativitayanan, Punyavee; Carrow, James K; Gaharwar, Akhilesh K
Recent progress in nanotechnology has stimulated the development of multifunctional biomaterials for tissue engineering applications. Synergistic interactions between nanomaterials and stem cell engineering offer numerous possibilities to address some of the daunting challenges in regenerative medicine, such as controlling trigger differentiation, immune reactions, limited supply of stem cells, and engineering complex tissue structures. Specifically, the interactions between stem cells and their microenvironment play key roles in controlling stem cell fate, which underlines therapeutic success. However, the interactions between nanomaterials and stem cells are not well understood, and the effects of the nanomaterials shape, surface morphology, and chemical functionality on cellular processes need critical evaluation. In this Review, focus is put on recent development in nanomaterial-stem cell interactions, with specific emphasis on their application in regenerative medicine. Further, the emerging technologies based on nanomaterials developed over the past decade for stem cell engineering are reviewed, as well as the potential applications of these nanomaterials in tissue regeneration, stem cell isolation, and drug/gene delivery. It is anticipated that the enhanced understanding of nanomaterial-stem cell interactions will facilitate improved biomaterial design for a range of biomedical and biotechnological applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Coyle, Robert; Jia, Jia; Mei, Ying
Stem cells hold remarkable promise for applications in tissue engineering and disease modeling. During the past decade, significant progress has been made in developing soluble factors (e.g., small molecules and growth factors) to direct stem cells into a desired phenotype. However, the current lack of suitable synthetic materials to regulate stem cell activity has limited the realization of the enormous potential of stem cells. This can be attributed to a large number of materials properties (e.g., chemical structures and physical properties of materials) that can affect stem cell fate. This makes it challenging to design biomaterials to direct stem cell behavior. To address this, polymer microarray technology has been developed to rapidly identify materials for a variety of stem cell applications. In this article, we summarize recent developments in polymer array technology and their applications in stem cell engineering. Stem cells hold remarkable promise for applications in tissue engineering and disease modeling. In the last decade, significant progress has been made in developing chemically defined media to direct stem cells into a desired phenotype. However, the current lack of the suitable synthetic materials to regulate stem cell activities has been limiting the realization of the potential of stem cells. This can be attributed to the number of variables in material properties (e.g., chemical structures and physical properties) that can affect stem cells. Polymer microarray technology has shown to be a powerful tool to rapidly identify materials for a variety of stem cell applications. Here we summarize recent developments in polymer array technology and their applications in stem cell engineering. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Kong, Xiaoqing; Dabney, Katherine P.; Tai, Robert H.
This study addresses the association between middle-school students' reported participation in science summer programmes and their reported expectation of a career in science and engineering. Data were collected on 1,580 students from eight middle schools in five states, applying an accelerated longitudinal design. Two consecutive cohorts were…
: as a means to operationalize the link between exhibit features and visitor activities; and as a template to transform scientists’ practices in the research context into visitors’ activities in the exhibit context. The resulting model of science exhibit engineering is presented and exemplified, and its......Recently, science museums have begun to review their educational purposes and redesign their pedagogies. At the most basic level, this entails accounting for the performance of individual exhibits, and indeed, in some cases, research indicates shortcomings in exhibit design: While often successful...... implications for science exhibit design are discussed at three levels: the design product, the design process, and the design methodology....
Zavrel, Erik A.
High school science teachers, of course, want to motivate their students to consider studying science and engineering (S&E) in college. However, many high school students are not familiar with what science and engineering actually entail. They may know science as little more than "systematic discovery" and engineering as nothing but…
West, Andrew B.; Sickel, Aaron J.; Cribbs, Jennifer D.
The Next Generation Science Standards call for the integration of science and engineering. Often, the introduction of engineering activities occurs after instruction in the science content. That is, engineering is used as a way for students to elaborate on science ideas that have already been explored. However, using only this sequence of…
material science, mechanics, physics, and chemistry to model and characterize the processing and performance of multifunctional materials and microsystems...Aerospace Material……………………………………..………………………………..12 4.2.1.Task A: Structure and chemistry across γ/γʹ interfaces in nickel -based superalloys………12 4.2.2. Task...B: Three-dimensional characterization of nanoscale γʹ precipitates in nickel -based superalloys……………………………..………………………………………………...15 4.2.3. Task C
Johnson, Dawn R.
Scholars have theorized and examined women's underrepresentation in science, technology, engineering and mathematics (STEM) fields for well over thirty years. However, much of this research has paid little attention to issues of racial and ethnic diversity among women, suggesting that all women have the same experiences in STEM. Women of color…
Brockopp, Dorothy; Isaacs, Mindy; Bischoff, Pam; Millerd, Kimberly
The purpose of this project was to assess the perceived efficacy of university-based activities designed to improve the recruitment and retention of women in academic science and engineering (S&E). Numerous approaches to recruitment and retention have been described and implemented but little change occurs. An evaluation of suggested activities by…
130 Foreign Affairs 633 Physical Therapist 1222 Patent Attorney 131 International Relations 644 Medical Technologist 1301 General Physical Science...132 Intelligence 662 Optometrist 1306 Health Physics 150 Geography 665 Speech Pathology and Audiology 1310 Physics 170 History 680 Dental Officer...Pharmacology 807 Landscape Architect 1360 Oceanography 408 Ecology 808 Architecture 1370 Cartography 410 Zoology 810 Civil Engineering 1372 Geodesy 413
Investigates students' persistence regarding career aspirations in science and engineering (SE) professional careers as a function of race and sex. In a sample of 8th graders, men were more likely to persist in SE career aspirations. Academic proficiency and math self-efficacy were 2 of the strongest predictors of persistence in SE careers.…
Top, J.L.; Wigham, M.; Rijgersberg, H.; Cheptov, A; Mavromoustakis, C
Tabular data are common in science and engineering. Datasets found in practice are often not very well specified, and are therefore hard to understand and use. Semantic standards are available to express the meaning and context of the data. However, present standards have their limitations in
Nakajima, Mitsutoshi; Wang, Zheng; Chaudhry, Qasim; Park, Hyun Jin; Juneja, Lekh R
Nanoscale Science, Engineering and Technology are applied to Food and Nutrition. Various delivery systems include nanoemulsions, microemulsions, solid lipid nanoparticles, micelles, and liposomes. The nanoscale systems have advantages, such as higher bioavailabitity, and other physicochemical properties. The symposium will provide an overview of the formulation, characterization, and utilization of nanotechnology-based food and nutrition.
The current buzz surrounding science, technology, engineering and math (STEM) disciplines and their economic importance is certainly justified. Unfortunately, when educators push to improve a specific discipline, it often has negative effects on everything else. While the STEM disciplines are important, focus on them is taking away from other…
Full Text Available The article is devoted to the problem of compliance with terms and definitions in medical science and engineering to the actual essence. One of the components of successful development of these trends is adequate linguistic support of the process of development and operation, basic level of determination and terms which indicated certain principles, approaches, processes and so on.
Christiansen, Thomas Lundin; Dahl, Kristian Vinter; Jellesen, Morten Stendahl
at the surface. Current research and innovation activities are used to exemplify thermochemical surface engineering and the interplay of science and innovation. The examples given encompass aspects of the synthesis of extremely porous materials, low temperature surface hardening of stainless steel, surface...
Computational science and engineering (CSE) software is written by experts of certain area(s). Due to the specialization,existing CSE software may need to integrate other CSE software systems developed by different groups of experts. Thecoupling problem is one of the challenges f...
Hundley, Jacqueline Holliday
Although the two-year curriculum guide includes coverage of all eight software engineering core topics, the computer science courses taught in Alabama community colleges limit student exposure to the programming, or coding, phase of the software development lifecycle and offer little experience in requirements analysis, design, testing, and…
This paper analysed the research output of academics in the science and engineering faculties of Federal Government-owned universities in Nigeria. It explored their level of research output during 1997-2006 in terms of the publication of journal articles and linked research and publication trends with place of publication ...
Cahan, Patrick; Li, Hu; Morris, Samantha A; Lummertz da Rocha, Edroaldo; Daley, George Q; Collins, James J
Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent powerful approaches to engineer cells for research and regenerative medicine. We have developed CellNet, a network biology platform that more accurately assesses the fidelity of cellular engineering than existing methodologies and generates hypotheses for improving cell derivations. Analyzing expression data from 56 published reports, we found that cells derived via directed differentiation more closely resemble their in vivo counterparts than products of direct conversion, as reflected by the establishment of target cell-type gene regulatory networks (GRNs). Furthermore, we discovered that directly converted cells fail to adequately silence expression programs of the starting population and that the establishment of unintended GRNs is common to virtually every cellular engineering paradigm. CellNet provides a platform for quantifying how closely engineered cell populations resemble their target cell type and a rational strategy to guide enhanced cellular engineering. Copyright © 2014 Elsevier Inc. All rights reserved.
Nguyen, Tien K; Ueno, Takafumi
Recent achievements in development of protein assembles within cells have extended biosupramolecular composites into a new era with versatile applications in the fields of biomaterial and biotechnology. Using methods with biological and physicochemical routes has made this era of research more interesting and challenging. Further advances in protein engineering have facilitated efficient fabrication of supramolecular complexes within living cells. Here, we provide a review of recent efforts to engineer protein assemblies within cells and describe the promising properties of these assemblies. Copyright © 2017 Elsevier Ltd. All rights reserved.
Singh, Chandralekha; Schunn, Christian
Recruiting and retaining highly qualified physics and physical science teachers is critical for maintaining America's global competitiveness. Unfortunately, only one third of the high school teachers in physics have a degree in physics and an even smaller number of physical science teachers in middle school have a good grasp of the scientific content they teach. Moreover, teachers often lack adequate pedagogical content knowledge to teach science effectively. Here, we discuss the development, implementation, and assessment of a course for science and engineering undergraduates designed to increase awareness and help them develop an interest and a deeper appreciation of the intellectual demands of physics teaching. The course focused on increasing student enthusiasm and confidence in teaching by providing well supported teaching opportunities and exposure to physics education research. The course assessment methods include 1) pre/post-test measures of attitude and expectations about science teaching, 2) self a...
Khan, Naeem Ullah
This study investigated the difference in the short-term memory span of students of three major groups, namely Social Sciences, Science and Engineering, and Business. This study was designed to answer the following two questions: (1) Is there a difference between short-term memory span, measured by digit span, among the students in or intended for Social Sciences, Science and Engineering, and Business majors? (2) Is there a difference of short-term memory span, measured by word span, among students in or intended for Social Sciences, Science and Engineering, and Business majors? For answering these two questions, inferential and descriptive statistics were used. Analysis of Variance (ANOVA) was used to compare the means of the scores of digit span and word span among the three major groups. The means of digit span and word span among the three groups were compared to find out if a statistically significant difference existed among them or not. The observations were recorded at the level of significance at alpha = .05, and highly significant at alpha = .01. The answer to the first question is yes. The results of this study showed a statistically significant difference in the means of the digit span of the three major groups of students in or intended for Social Sciences, Science and Engineering, and Business. The mean scaled score for digit span was 12.88 for Social Sciences, 14.27 for Science and Engineering, and 15.33 for Business majors, respectively. The means of the free recalls word span of the three groups was 7.23 for Social Sciences, 7.89 for Science and Engineering, and 7.12 for Business majors, respectively. No significant difference was observed in the means of the word span of the three groups. In general observations, it is noted that students want to stay in the subjects or majors in which they can perform well or feel comfortable. In addition to this, students are screened in the school system due to levels of performance or selection pressure
Ortiz Monica E
Full Text Available Abstract Background Evolution has selected for organisms that benefit from genetically encoded cell-cell communication. Engineers have begun to repurpose elements of natural communication systems to realize programmed pattern formation and coordinate other population-level behaviors. However, existing engineered systems rely on system-specific small molecules to send molecular messages among cells. Thus, the information transmission capacity of current engineered biological communication systems is physically limited by specific biomolecules that are capable of sending only a single message, typically “regulate transcription.” Results We have engineered a cell-cell communication platform using bacteriophage M13 gene products to autonomously package and deliver heterologous DNA messages of varying lengths and encoded functions. We demonstrate the decoupling of messages from a common communication channel via the autonomous transmission of various arbitrary genetic messages. Further, we increase the range of engineered DNA messaging across semisolid media by linking message transmission or receipt to active cellular chemotaxis. Conclusions We demonstrate decoupling of a communication channel from message transmission within engineered biological systems via the autonomous targeted transduction of user-specified heterologous DNA messages. We also demonstrate that bacteriophage M13 particle production and message transduction occurs among chemotactic bacteria. We use chemotaxis to improve the range of DNA messaging, increasing both transmission distance and communication bit rates relative to existing small molecule-based communication systems. We postulate that integration of different engineered cell-cell communication platforms will allow for more complex spatial programming of dynamic cellular consortia.
The Global Conference on Applied Computing in Science and Engineering is organized by academics and researchers belonging to different scientific areas of the C3i/Polytechnic Institute of Portalegre (Portugal) and the University of Extremadura (Spain) with the technical support of ScienceKnow Conferences. The event has the objective of creating an international forum for academics, researchers and scientists from worldwide to discuss worldwide results and proposals regarding to the soundest issues related to Applied Computing in Science and Engineering. This event will include the participation of renowned keynote speakers, oral presentations, posters sessions and technical conferences related to the topics dealt with in the Scientific Program as well as an attractive social and cultural program. The papers will be published in the Proceedings e-books. The proceedings of the conference will be sent to possible indexing on Thomson Reuters (selective by Thomson Reuters, not all-inclusive) and Google Scholar...
Gong, Zhiwei; Nielsen, Jens; Zhou, Yongjin J
Metabolic engineering and synthetic biology offer great prospects in developing microbial cell factories capable of converting renewable feedstocks into fuels, chemicals, food ingredients, and pharmaceuticals. However, prohibitively low production rate and mass concentration remain the major hurdles in industrial processes even though the biosynthetic pathways are comprehensively optimized. These limitations are caused by a variety of factors unamenable for host cell survival, such as harsh industrial conditions, fermentation inhibitors from biomass hydrolysates, and toxic compounds including metabolic intermediates and valuable target products. Therefore, engineered microbes with robust phenotypes is essential for achieving higher yield and productivity. In this review, the recent advances in engineering robustness and tolerance of cell factories is described to cope with these issues and briefly introduce novel strategies with great potential to enhance the robustness of cell factories, including metabolic pathway balancing, transporter engineering, and adaptive laboratory evolution. This review also highlights the integration of advanced systems and synthetic biology principles toward engineering the harmony of overall cell function, more than the specific pathways or enzymes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Ng, Johnathan; Bernhard, Jonathan; Vunjak-Novakovic, Gordana
Mesenchymal stem cells (MSC) are of major interest in regenerative medicine, as they are easily harvested from a variety of sources (including bone marrow and fat aspirates) and they are able to form a range of mesenchymal tissues, in vitro and in vivo. We focus here on the use of MSCs for engineering of cartilage, bone, and complex osteochondral tissue constructs, using protocols that replicate some aspects of natural mesodermal development. For engineering of human bone, we discuss some of the current advances, and highlight the use of perfusion bioreactors for supporting anatomically exact human bone grafts. For engineering of human cartilage, we discuss the limitations of current approaches, and highlight engineering of stratified, mechanically functional human cartilage interfaced with bone by mesenchymal condensation of MSCs. Taken together, current advances enable engineering of physiologically relevant bone, cartilage and osteochondral composites, and physiologically relevant studies of osteochondral development and disease.
Bhatia, Sangeeta N.; Underhill, Gregory H.; Zaret, Kenneth S.; Fox, Ira J.
Despite the tremendous hurdles presented by the complexity of the liver’s structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near and long-term prospects for such cell-based therapies and the unique challenges for clinical translation. PMID:25031271
Simon, Tiffany Monique
The purpose of this qualitative study was to identify factors that influence African Americans to pursue and complete doctoral degrees in engineering and applied science disciplines. Critical race theory (CRT), two models of doctoral student persistence, and graduate student persistence literature guided the conceptual framework of this study. In-depth and focus group interviews were conducted to learn the key factors that positively impacted the persistence of 19 African Americans who earned doctoral degrees in engineering and applied science. The following two factors were found to significantly contribute to the decision to pursue the doctorate: encouragement from others and participation in a research or internship program. Key factors impacting doctoral degree completion included: peer support, faculty adviser support, support from university administrators, and family support. In addition to identifying factors that influenced 19 African Americans to pursue and complete doctoral degrees in engineering and applied science, this study was about the importance of diversity and inclusion of multiple perspectives in education research and scholarship. To this end, the study served to promote and include the expert knowledge of African American doctoral degree recipients in engineering and applied science in the scholarly discourse on the issue of low participation rates of African Americans in engineering and applied science disciplines. Such knowledge will challenge traditional views on this issue and hopefully inspire new ways of addressing and remedying this issue. With African Americans and other minority populations growing at an exponential rate, people of color are quickly becoming the majority in key states across the nation. Therefore, it is imperative that all Americans have an opportunity to develop skills necessary to compete for professional positions in the science and engineering workforce. This mandate is required for the United States to maintain
This Ph.D. thesis studies issues in the area of construction informatics. Construction informatics is the theoretical study of formal and conceptual aspects in the domain of civil engineering and design. The thesis is a collection of papers which each treat a specific subject within domain analysis...... and conceptual modelling of civil engineering and design. Due to the interdisciplinary content, the first half of the study has been carried out at Department of Civil Engineering (BYG"DTU), The Technical University of Denmark; whereas the second half has been carried out at Informatics and Mathematical....... The issues of the thesis are treated from three angles: from computer science, from civil engineering and design theory, and from philosophy. It is characteristic for the thesis that these angles are all present in analysis and argumentation. The philosophical aspect is a natural ingredient as construction...
Titorencu, Irina; Albu, Madalina Georgiana; Nemecz, Miruna; Jinga, Victor V
The major goal of bone tissue engineering is to develop bioconstructs which substitute the functionality of damaged natural bone structures as much as possible if critical-sized defects occur. Scaffolds that mimic the structure and composition of bone tissue and cells play a pivotal role in bone tissue engineering applications. First, composition, properties and in vivo synthesis of bone tissue are presented for the understanding of bone formation. Second, potential sources of osteoprogenitor cells have been investigated for their capacity to induce bone repair and regeneration. Third, taking into account that the main property to qualify one scaffold as a future bioconstruct for bone tissue engineering is the biocompatibility, the assessments which prove it are reviewed in this paper. Forth, various types of natural polymer- based scaffolds consisting in proteins, polysaccharides, minerals, growth factors etc, are discussed, and interaction between scaffolds and cells which proved bone tissue engineering concept are highlighted. Finally, the future perspectives of natural polymer-based scaffolds for bone tissue engineering are considered. Copyright© Bentham Science Publishers; For any queries, please email at firstname.lastname@example.org.
Clarke, Katie C.
A new Science, Engineering and Technology (SET) approach was designed for youth who participated in the Minnesota State Fair Livestock interview process. The project and evaluation were designed to determine if the new SET approach increased content knowledge and science process skills in participants. Results revealed that youth participants not…
Full Text Available Article deals with ways in which social sciences and humanities have been integrated from the 1980s to the present day into curriculum of Faculty of Mechanical Engineering and Naval Architecture at University of Zagreb, Croatia. After a brief review and summary of selected research and theoretical contributions to the subject theme, a specific research setting is indicated and contextualized. Elements of socio-historical approach are established primarily through analysis of corresponding documents: curriculums from the 1980s, 1990s and 2000s and from key documents on strategic development of the Faculty. It is stressed that social sciences and humanities topics are continually represented in mechanical engineering study program as legitimate, but separate unit, poorly integrated in the main engineering courses. Together with more or less expressed orientation toward micro-social and micro-economical issues in industry and business, it points to the main features in continuity of establishing the field of social sciences and humanities. Finally, it is shown that chances to widen and enrich aforementioned field are in close relation to the character of engineering and its social contextualization expressed in a key Faculty’s strategic documents.
Lange, Matthias; Spies, Karl; Bargsten, Joachim; Haberhauer, Gregor; Klapperstück, Matthias; Leps, Michael; Weinel, Christian; Wünschiers, Röbbe; Weissbach, Mandy; Stein, Jens; Scholz, Uwe
Search engines and retrieval systems are popular tools at a life science desktop. The manual inspection of hundreds of database entries, that reflect a life science concept or fact, is a time intensive daily work. Hereby, not the number of query results matters, but the relevance does. In this paper, we present the LAILAPS search engine for life science databases. The concept is to combine a novel feature model for relevance ranking, a machine learning approach to model user relevance profiles, ranking improvement by user feedback tracking and an intuitive and slim web user interface, that estimates relevance rank by tracking user interactions. Queries are formulated as simple keyword lists and will be expanded by synonyms. Supporting a flexible text index and a simple data import format, LAILAPS can easily be used both as search engine for comprehensive integrated life science databases and for small in-house project databases. With a set of features, extracted from each database hit in combination with user relevance preferences, a neural network predicts user specific relevance scores. Using expert knowledge as training data for a predefined neural network or using users own relevance training sets, a reliable relevance ranking of database hits has been implemented. In this paper, we present the LAILAPS system, the concepts, benchmarks and use cases. LAILAPS is public available for SWISSPROT data at http://lailaps.ipk-gatersleben.de.
Research opportunities in corrosion science and engineering: Committee on Research Opportunities in Corrosion Science and Engineering, National Materials Advisory Board, Division on Engineering and Physical Sciences, National Research Council of the National Academies
"[This book] identifies grand challenges for the corrosion research community, highlights research opportunities in corrosion science and engineering, and posits a national strategy for corrosion research...
The Hydrogen Fuel Cell Engines and Related Technologies report documents the first training course ever developed and made available to the transportation community and general public on the use hydrogen fuel cells in transportation. The course is designed to train a new generation of technicians in gaining a more complete understanding of the concepts, procedures, and technologies involved with hydrogen fuel cell use in transportation purposes. The manual contains 11 modules (chapters). The first eight modules cover (1) hydrogen properties, use and safety; and (2) fuel cell technology and its systems, fuel cell engine design and safety, and design and maintenance of a heavy duty fuel cell bus engine. The different types of fuel cells and hybrid electric vehicles are presented, however, the system descriptions and maintenance procedures focus on proton-exchange-membrane (PEM) fuel cells with respect to heavy duty transit applications. Modules 9 and 10 are intended to provide a better understanding of the acts, codes, regulations and guidelines concerning the use of hydrogen, as well as the safety guidelines for both hydrogen maintenance and fueling facilities. Module 11 presents a glossary and conversions.
Xie, Mingqi; Fussenegger, Martin
Biotechnology is a widely interdisciplinary field focusing on the use of living cells or organisms to solve established problems in medicine, food production and agriculture. Synthetic biology, the science of engineering complex biological systems that do not exist in nature, continues to provide the biotechnology industry with tools, technologies and intellectual property leading to improved cellular performance. One key aspect of synthetic biology is the engineering of deliberately reprogrammed designer cells whose behavior can be controlled over time and space. This review discusses the most commonly used techniques to engineer mammalian designer cells; while control elements acting on the transcriptional and translational levels of target gene expression determine the kinetic and dynamic profiles, coupling them to a variety of extracellular stimuli permits their remote control with user-defined trigger signals. Designer mammalian cells with novel or improved biological functions not only directly improve the production efficiency during biopharmaceutical manufacturing but also open the door for cell-based treatment strategies in molecular and translational medicine. In the future, the rational combination of multiple sets of designer cells could permit the construction and regulation of higher-order systems with increased complexity, thereby enabling the molecular reprogramming of tissues, organisms or even populations with highest precision. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Vick, Matthew E.; Garvey, Michael P.
The Boy Scouts of America's Environmental Science and Engineering merit badges are two of their over 120 merit badges offered as a part of a non-formal educational program to U.S. boys. The Scientific and Engineering Practices of the U.S. Next Generation Science Standards provide a vision of science education that includes integrating eight…
For a wide variety of scientific and engineering problems the desired solution corresponds to an optimal set of objective function parameters, where the objective function measures a solution's quality. The main goal of the LDRD ''Global Optimization for Engineering Science Problems'' was the development of new robust and efficient optimization algorithms that can be used to find globally optimal solutions to complex optimization problems. This SAND report summarizes the technical accomplishments of this LDRD, discusses lessons learned and describes open research issues.
Humphrey, Jay D
Scientists and engineers seek to discover and disseminate knowledge so that it can be used to improve the human condition. Style and Ethics of Communication in Science and Engineering serves as a valuable aid in this pursuit-it can be used as a textbook for undergraduate or graduate courses on technical communication and ethics, a reference book for senior design courses, or a handbook for young investigators and beginning faculty members. In addition to presenting methods for writing clearly and concisely and improving oral presentations, this compact book provides practical guidelines for pr
DuBose, Ronald Arthur
A stream conditioning system for a fuel cell gas management system or fuel cell engine. The stream conditioning system manages species potential in at least one fuel cell reactant stream. A species transfer device is located in the path of at least one reactant stream of a fuel cell's inlet or outlet, which transfer device conditions that stream to improve the efficiency of the fuel cell. The species transfer device incorporates an exchange media and a sorbent. The fuel cell gas management system can include a cathode loop with the stream conditioning system transferring latent and sensible heat from an exhaust stream to the cathode inlet stream of the fuel cell; an anode humidity retention system for maintaining the total enthalpy of the anode stream exiting the fuel cell related to the total enthalpy of the anode inlet stream; and a cooling water management system having segregated deionized water and cooling water loops interconnected by means of a brazed plate heat exchanger.
Li, Yuan-Sheng; Harn, Horng-Jyh; Hsieh, Dean-Kuo; Wen, Tung-Chou; Subeq, Yi-Maun; Sun, Li-Yi; Lin, Shinn-Zong; Chiou, Tzyy-Wen
Liver transplantation is currently the most efficacious treatment for end-stage liver diseases. However, one main problem with liver transplantation is the limited number of donor organs that are available. Therefore, liver tissue engineering based on cell transplantation that combines materials to mimic the liver is under investigation with the goal of restoring normal liver functions. Tissue engineering aims to mimic the interactions among cells with a scaffold. Particular materials or a matrix serve as a scaffold and provide a three-dimensional environment for cell proliferation and interaction. Moreover, the scaffold plays a role in regulating cell maturation and function via these interactions. In cultures of hepatic lineage cells, regulation of cell proliferation and specific function using biocompatible synthetic, biodegradable bioderived matrices, protein-coated materials, surface-modified nanofibers, and decellularized biomatrix has been demonstrated. Furthermore, beneficial effects of addition of growth factor cocktails to a flow bioreactor or coculture system on cell viability and function have been observed. In addition, a system for growing stem cells, liver progenitor cells, and primary hepatocytes for transplantation into animal models was developed, which produces hepatic lineage cells that are functional and that show long-term proliferation following transplantation. The major limitation of cells proliferated with matrix-based transplantation systems is the high initial cell loss and dysfunction, which may be due to the absence of blood flow and the changes in nutrients. Thus, the development of vascular-like scaffold structures, the formation of functional bile ducts, and the maintenance of complex metabolic functions remain as major problems in hepatic tissue engineering and will need to be addressed to enable further advances toward clinical applications.
Photo 01: Dr Pierre Perrolle, Director, Office of International Science and Engineering, National Science Foundation, USA (second from right) in the ATLAS assembly hall with from left to right Randi Ruchti, Peter Jenni and Robert Eisenstein, Senior Science Advisor, National Science Foundation, USA. Photo 02: Dr Pierre Perrolle, Director, Office of International Science and Engineering, National Science Foundation, USA (second from right) in the ATLAS assembly hall with from left to right Randi Ruchti, Robert Eisenstein, Senior Science Advisor, National Science Foundation, USA and Peter Jenni. Photo 03: Dr Pierre Perrolle, Director, Office of International Science and Engineering, National Science Foundation, USA (second from right) in front of the ATLAS End-Cap Toroid vacuum vessel in the ATLAS assembly hall with from left to right Peter Jenni, Robert Eisenstein, Senior Science Advisor, National Science Foundation, USA and Randi Ruchti ________________________________
The National Aeronautics and Space Administration's Science and Engineering Apprentice Program for high school students is one of NASA's many efforts toward a goal of scientific literacy. It embraces science, mathematics, and technology as keys to purposeful and sustained progress and security for our nation and its people. It serves as a model for helping reform education by striving to address mechanisms to influence the knowledge, skills, and attitudes of our students. It focuses on what to do today to meet the challenges of tomorrow.
Myers, Raymond H; Vining, G Geoffrey; Robinson, Timothy J
Praise for the First Edition "The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities."-Technometrics Generalized Linear Models: With Applications in Engineering and the Sciences, Second Edition continues to provide a clear introduction to the theoretical foundations and key applications of generalized linear models (GLMs). Ma
Wang, Xiaoping; Zheng, Zhenrong; Wang, Kaiwei; Zheng, Xiaodong; Ye, Song; Zhu, Yuhui
The optimized curriculum of College of Optical Science and Engineering is accomplished at Zhejiang University, based on new trends from both research and industry. The curriculum includes general courses, foundation courses such as mathematics and physics, major core courses, laboratory courses and several module courses. Module courses include optical system designing, optical telecommunication, imaging and vision, electronics and computer science, optoelectronic sensing and metrology, optical mechanics and materials, basics and extension. These curricula reflect the direction of latest researches and relates closely with optoelectronics. Therefore, students may combine flexibly compulsory courses with elective courses, and establish the personalized curriculum of "optoelectronics + X", according to their individual strengths and preferences.
Tandon, Nina; Marolt, Darja; Cimetta, Elisa; Vunjak-Novakovic, Gordana
Stem cells hold promise to revolutionize modern medicine by development of new therapies, disease models and drug screening systems. Standard cell culture systems have limited biological relevance because they do not recapitulate the complex 3-dimensional interactions and biophysical cues that characterize the in vivo environment. In this review, we discuss the current advances in engineering stem cell environments using novel biomaterials and bioreactor technologies. We also reflect on the challenges the field is currently facing with regard to translation of stem cell based therapies into the clinic. PMID:23531529
Kröner, Dietmar; Resch, Michael
This book presents the state-of-the-art in supercomputer simulation. It includes the latest findings from leading researchers using systems from the High Performance Computing Center Stuttgart (HLRS). The reports cover all fields of computational science and engineering ranging from CFD to computational physics and from chemistry to computer science with a special emphasis on industrially relevant applications. Presenting findings of one of Europe’s leading systems, this volume covers a wide variety of applications that deliver a high level of sustained performance. The book covers the main methods in high-performance computing. Its outstanding results in achieving the best performance for production codes are of particular interest for both scientists and engineers. The book comes with a wealth of color illustrations and tables of results.
Full Text Available The "four essential factors" of materials science and engineering,including composition (component and structure, synthesis and process, property and service behavior, were explained. The proposal of "four essential factors" ends the chaotic state of materials research and bridges the gulf between the theory and industry. Based on these, reliable materials with ultimate congenital properties are obtained, and advanced materials can be developed rapidly. Moreover, author raised the concept of "two whole processes", namely the whole process of materials development and the whole process of materials application research. The implementation of the two whole processes on a high level can ensure the acquisition of reliable and useful materials with ultimate congenital and ultimate service properties, which will lead "materials science and engineering" into a new era and enable China to be a powerful country in the field of materials.
Hwang, Jangsun; Jeong, Yoon; Park, Jeong Min; Lee, Kwan Hong; Hong, Jong Wook; Choi, Jonghoon
Biomimetics is the study of nature and natural phenomena to understand the principles of underlying mechanisms, to obtain ideas from nature, and to apply concepts that may benefit science, engineering, and medicine. Examples of biomimetic studies include fluid-drag reduction swimsuits inspired by the structure of shark's skin, velcro fasteners modeled on burrs, shape of airplanes developed from the look of birds, and stable building structures copied from the backbone of turban shells. In this article, we focus on the current research topics in biomimetics and discuss the potential of biomimetics in science, engineering, and medicine. Our report proposes to become a blueprint for accomplishments that can stem from biomimetics in the next 5 years as well as providing insight into their unseen limitations.
CSIE2012 is an integrated conference concentrating its focus on Computer Science and Information Engineering . In the proceeding, you can learn much more knowledge about Computer Science and Information Engineering of researchers from all around the world. The main role of the proceeding is to be used as an exchange pillar for researchers who are working in the mentioned fields. In order to meet the high quality of Springer, AISC series, the organization committee has made their efforts to do the following things. Firstly, poor quality paper has been refused after reviewing course by anonymous referee experts. Secondly, periodically review meetings have been held around the reviewers about five times for exchanging reviewing suggestions. Finally, the conference organizers had several preliminary sessions before the conference. Through efforts of different people and departments, the conference will be successful and fruitful.
CSIE2012 is an integrated conference concentrating its focus on Computer Science and Information Engineering . In the proceeding, you can learn much more knowledge about Computer Science and Information Engineering of researchers from all around the world. The main role of the proceeding is to be used as an exchange pillar for researchers who are working in the mentioned fields. In order to meet the high quality of Springer, AISC series, the organization committee has made their efforts to do the following things. Firstly, poor quality paper has been refused after reviewing course by anonymous referee experts. Secondly, periodically review meetings have been held around the reviewers about five times for exchanging reviewing suggestions. Finally, the conference organizers had several preliminary sessions before the conference. Through efforts of different people and departments, the conference will be successful and fruitful.
Learning how to write clearly and concisely is an integral part of furthering your research career; however, doing so is not always easy. In this second edition, fully updated and revised, Dr. Silyn-Roberts explains in plain English the steps to writing abstracts, theses, journal papers, funding bids, literature reviews, and more. The book also examines preparing seminar and conference presentations. Written in a practical and easy to follow style specifically for postgraduate students in Engineering and Sciences, this book is essential in learning how to create powerful documents. Writing for Science and Engineering will prove invaluable in all areas of research and writing due its clear, concise style. The practical advice contained within the pages alongside numerous examples to aid learning will make the preparation of documentation much easier for all students.
..., Women, Minorities and Persons with Disabilities in Science and Engineering: 2013 The 2011-2012 Biennial... Committee on Equal Opportunities in Science and Engineering; Notice of Meeting In accordance with the... the following meeting. Name: Committee on Equal Opportunities in Science and Engineering (CEOSE...
This paper investigates reasons for practices and policies that are designed to promote higher levels of enrollment by women in scientific disciplines. It challenges the assumptions and problematic arguments of a recent article questioning their legitimacy. Considering the motivations for and merits of such programs suggests a practical response to the question of whether there should be programs to attract female science and engineering students.
The "four essential factors" of materials science and engineering,including composition (component) and structure, synthesis and process, property and service behavior, were explained. The proposal of "four essential factors" ends the chaotic state of materials research and bridges the gulf between the theory and industry. Based on these, reliable materials with ultimate congenital properties are obtained, and advanced materials can be developed rapidly. Moreover, author raised the concept of...
presentation : "La Loi de la Performance Humaine et se s 9 Applications pour l’enseignement, l’ apprentissage, et la recherche," By Diola Bagayoko...were not cellular phones, Internet , genome maps, sophisticated transportation means, nano-materials, global warming, or spac e tourism, etc. It is...Globa l Climate Change Research (with possible application to other planets), Materials Science , Engineering, and Technology (MSET), Genomics and the
Fletcher, Daniel; Gerecht, Sharon; Levine, Ross; Mallick, Parag; McCarty, Owen; Munn, Lance; Reinhart-King, Cynthia
This book presents an Assessment of Physical Sciences and Engineering Advances in Life Sciences and Oncology (APHELION) by a panel of experts. It covers the status and trends of applying physical sciences and engineering principles to oncology research in leading laboratories and organizations in Europe and Asia. The book elaborates on the six topics identified by the panel that have the greatest potential to advance understanding and treatment of cancer, each covered by a chapter in the book. The study was sponsored by the National Cancer Institute (NCI) at the National Institute of Health (NIH), the National Science Foundation (NSF) and the National Institute of Biomedical Imaging and Bioengineering at the NIH in the US under a cooperative agreement with the World Technology Evaluation Center (WTEC).
A science methods instructor intentionally encouraged cell phone use for class work to discover how cell phones can be used as research tools to enhance the content and engage the students. The anecdotal evidence suggested that students who used their smartphones as research tools experienced the science content and pedagogical information…
Schroeder, J O; Pearson, E W; Thomas, J J; Brothers, J W; Campbell, W K; DeVaney, D M; Jones, D R; Littlefield, R J; Peterson, M J
This document presents the preliminary design concept for the integrated computing and information system to be included in the Environmental and Molecular Sciences Laboratory (EMSL) at the Pacific Northwest Laboratory, Richland, Washington, for the US Department of Energy (DOE). The EMSL is scheduled for completion and occupancy in 1994 or 1995 and will support the DOE environmental mission, in particular hazardous waste remediation. The focus of the report is on the Computing and Information Sciences engineering task of providing a fully integrated state-of-the-art computing environment for simulation, experimentation and analysis in support of molecular research. The EMSL will house two major research organizations, the Molecular Sciences Research Center (MSRC) and part of the Environmental Sciences Research Center (ESRC). Included in the report is a preliminary description of the computing and information system to be included. The proposed system architecture is based on a preliminary understanding of the EMSL users' needs for computational resources. As users understand more about the scientific challenges they face, the definition of the functional requirements will change. At the same time, the engineering team will be gaining experience with new computing technologies. Accordingly, the design architecture must evolve to reflect this new understanding of functional requirements and enabling technologies. 3 figs., 2 tabs.
Radisic, Milica; Christman, Karen L
Heart failure after a myocardial infarction continues to be a leading killer in the Western world. Currently, there are no therapies that effectively prevent or reverse the cardiac damage and negative left ventricular remodeling process that follows a myocardial infarction. Because the heart has limited regenerative capacity, there has been considerable effort to develop new therapies that could repair and regenerate the myocardium. Although cell transplantation alone was initially studied, more recently, tissue engineering strategies using biomaterial scaffolds have been explored. In this review, we cover the different approaches to engineering the myocardium, including cardiac patches, which are in vitro-engineered constructs of functional myocardium, and injectable scaffolds, which can either encourage endogenous repair and regeneration or act as vehicles to support the delivery of cells and other therapeutics. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
Read this book before you write your thesis or journal paper! Communicating Science is a textbook and reference on scientific writing oriented primarily at researchers in the physical sciences and engineering. It is written from the perspective of an experienced researcher. It draws on the authors' experience of teaching and working with both native English speakers and English as a Second Language (ESL) writers. For the range of topics covered, this book is relatively short and tersely written, in order to appeal to busy researchers.Communicating Science offers comprehensive guidance on: Graduate students and early career researchers will be guided through the researcher's basic communication tasks: writing theses, journal papers, and internal reports, presenting lectures and posters, and preparing research proposals. Extensive best practice examples and analyses of common problems are presented. Advanced researchers who aim to commercialize their research results will be introduced to business plans and pat...
Zhang, Ling; Morgan, Richard A
In the past two decades, human gene transfer research has been translated from a laboratory technology to clinical evaluation. The success of adoptive transfer of tumor-reactive lymphocytes to treat the patients with metastatic melanoma has led to new strategies to redirect normal T cells to recognize tumor antigens by genetic engineering with tumor antigen-specific T cell receptor (TCR) genes. This new strategy can generate large numbers of defined antigen-specific cells for therapeutic application. Much progress has been made to TCR gene transfer systems by optimizing gene expression and gene transfer protocols. Vector and protein modifications have enabled excellent expression of introduced TCR chains in human lymphocytes with reduced mis-pairing between the introduced and endogenous TCR chains. Initial clinical studies have demonstrated that TCR gene-engineered T cells could mediate tumor regression in vivo. In this review, we discuss the progress and prospects of TCR gene-engineered T cells as a therapeutic strategy for treating patients with melanoma and other cancers. Published by Elsevier B.V.
Aldrich, Michele, Comp.; Leach, Alicia, Comp.
Provided is a list of associations and committees of or for women in science, engineering, mathematics, and medicine. The list is organized by discipline, with cross-referencing to cognate specialties. The disciplines include: anthropology; astronomy; atmospheric sciences; biology; chemistry; computer sciences; earth sciences; energy; engineering;…
... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the Minority Science and... ENGINEERING IMPROVEMENT PROGRAM General § 637.4 What definitions apply to the Minority Science and Engineering..., physical, behavorial and social sciences, and the history and philosophy of science; also included are...
... TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National Science and Technology Council; Notice of Public Meeting AGENCY: Executive Office of the President, Office of Science and Technology Policy. ACTION: Notice of Public Meeting. SUMMARY: The National...
... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Advisory Committee for Computer and Information Science and Engineering Notice of Meeting In accordance... announces the following meeting: NAME: Advisory Committee for Computer and Information Science and...
Brazziel, William E.; Brazziel, Marian E.
This analysis looked at doctorate completion in science and engineering (S&E) by underrepresented minorities: blacks, Hispanics and Indian Americans. These are the groups we must increasingly depend upon to make up for shortfalls in science and engineering doctorate production among American citizens. These shortfalls derive from truncated birth rates among white people, for the most part. The analysis answered several questions officials will need to know the answers to if we are to plan effectively to develop the talents of these individuals. Specifically, the National Science Foundation asked us to look at the feasibility of involving nontraditional minority science and engineering graduates (baccalaureates at 25+) as doctoral starts, along with minority S&E graduates who had taken jobs with corporations to pay off student loans and military personnel involved in S&E study and S&E work (see NSF report of research under grant SED-9107756). We found that nontraditional minority S&E doctorate recipients matched their traditional counterparts in elapsed time to degree and similar indicators. They had less in the way of support for doctoral study, however. We found that minority S&E graduates who took jobs in corporations were keenly interested in returning to campus to complete degrees. We also found that many bright minority youngsters are studying S&E subjects in the Community College of the Air Force and in U.S. Army SOC colleges. Some have enrolled in baccalaureate programs on university campuses and plan to continue on to the PhD. We concluded that money is important in tapping these talent pools to make up for the demographically driven shortfalls discussed above.
Mohtar, R. H.; Whittaker, A.; Amar, N.; Burgess, W.
Food, Environment, Engineering and Life Sciences Program Nadia Amar, Wiella Burgess, Rabi H. Mohtar, and Dale Whitaker Purdue University Correspondence: email@example.com FEELS, the Food, Environment, Engineering and Life Sciences Program is a grant of the National Science Foundation for the College of Agriculture at Purdue University. FEELS’ mission is to recruit, retain, and prepare high-achieving students with financial difficulties to pursue STEM (Science, Technology, Engineering, and Mathematics) careers. FEELS achieves its goals offering a scholarship of up to 10,000 per student each year, academic, research and industrial mentors, seminars, study tables, social and cultural activities, study abroad and community service projects. In year one, nine low-income, first generation and/or ethnic minority students joined the FEELS program. All 9 FEELS fellows were retained in Purdue’s College of Agriculture (100%) with 7 of 9 (77.7%) continuing to pursue STEM majors. FEELS fellows achieved an average GPA in their first year of 3.05, compared to the average GPA of 2.54 for low-income non- FEELS students in the College of Agriculture. A new cohort of 10 students joined the program in August 2009. FEELS fellows received total scholarships of nearly 50,000 for the 2008-2009 academic year. These scholarships were combined with a holistic program that included the following key elements: FEELS Freshman Seminars I and II, 2 study tables per week, integration activities and frequent meetings with FEELS academic mentors and directors. Formative assessments of all FEELS activities were used to enhance the first year curriculum for the second cohort. Cohort 1 will continue into their second year where the focus will be on undergraduate research. More on FEELS programs and activities: www.purdue.edu/feels.
Samuel, Rekha; Duda, Dan G; Fukumura, Dai; Jain, Rakesh K
The discovery of human induced pluripotent stem cells (hiPSCs) might pave the way toward a long-sought solution for obtaining sufficient numbers of autologous cells for tissue engineering. Several methods exist for generating endothelial cells or perivascular cells from hiPSCs in vitro for use in the building of vascular tissue. We discuss current developments in the generation of vascular progenitor cells from hiPSCs and the assessment of their functional capacity in vivo, opportunities and challenges for the clinical translation of engineered vascular tissue, and modeling of vascular diseases using hiPSC-derived vascular progenitor cells. Copyright © 2015, American Association for the Advancement of Science.
This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April l, 1988 through September 30, 1988.
Boice, Daniel C.; Asbell, E.; Reiff, P. H.
Young Engineers and Scientists (YES) is a community partnership between Southwest Research Institute (SwRI), and local high schools in San Antonio, Texas (USA) during the past 16 years. The YES program provides talented high school juniors and seniors a bridge between classroom instruction and real world, research experiences in physical sciences (including space science) and engineering. YES consists of two parts: 1) an intensive three-week summer workshop held at SwRI where students experience the research environment first-hand; develop skills and acquire tools for solving scientific problems, attend mini-courses and seminars on electronics, computers and the Internet, careers, science ethics, and other topics; and select individual research projects to be completed during the academic year; and 2) a collegial mentorship where students complete individual research projects under the guidance of their mentors during the academic year and earn honors credit. At the end of the school year, students publicly present and display their work, acknowledging their accomplishments and spreading career awareness to other students and teachers. During these years, YES has developed a website for topics in space science from the perspective of high school students, including NASA's Magnetospheric Multiscale Mission (MMS) (http://yesserver.space.swri.edu). High school science teachers participate in the workshop and develop space-related lessons for classroom presentation in the academic year. Student evaluations indicate the effectiveness of YES on their academic preparation and choice of college majors. Over the past 16 years, all YES graduates have entered college, several have worked for SwRI, one business has started, and three scientific publications have resulted. Acknowledgements. We acknowledge funding and support from the NASA MMS Mission, Texas Space Grant Consortium, Northside Independent School District, SwRI, and several local charitable foundations.
Hynes, Morgan; Swenson, Jessica
Mathematics and science knowledge/skills are most commonly associated with engineering's pre-requisite knowledge. Our goals in this paper are to argue for a more systematic inclusion of social science and humanities knowledge in the introduction of engineering to K-12 students. As part of this argument, we present a construct for framing the…
Pulkkinen, A.; Bernabeu, E.; Thomson, A.; Viljanen, A.; Pirjola, R.; Boteler, D.; Eichner, J.; Cilliers, P. J.; Welling, D.; Savani, N. P.; Weigel, R. S.; Love, J. J.; Balch, C.; Ngwira, C. M.; Crowley, G.; Schultz, A.; Kataoka, R.; Anderson, B.; Fugate, D.; Simpson, J. J.; MacAlester, M.
This paper is the primary deliverable of the very first NASA Living With a Star Institute Working Group, Geomagnetically Induced Currents (GIC) Working Group. The paper provides a broad overview of the current status and future challenges pertaining to the science, engineering, and applications of the GIC problem. Science is understood here as the basic space and Earth sciences research that allows improved understanding and physics-based modeling of the physical processes behind GIC. Engineering, in turn, is understood here as the "impact" aspect of GIC. Applications are understood as the models, tools, and activities that can provide actionable information to entities such as power systems operators for mitigating the effects of GIC and government agencies for managing any potential consequences from GIC impact to critical infrastructure. Applications can be considered the ultimate goal of our GIC work. In assessing the status of the field, we quantify the readiness of various applications in the mitigation context. We use the Applications Readiness Level (ARL) concept to carry out the quantification.
Kendall, E. A.; Valentic, T. A.; Stehle, R. H.
Under an Arctic Research Support and Logistics contract from NSF (GEO/PLR), SRI International, as part of the CH2M HILL Polar Services (CPS) program, forms partnerships with Arctic research teams to provide data transfer, remote operations, and safety/operations communications. This teamwork is integral to the success of real-time science results and often allows for unmanned operations which are both cost-effective and safer. The CPS program utilizes a variety of communications networks, services and technologies to support researchers and instruments throughout the Arctic, including Iridium, VSAT, Inmarsat BGAN, HughesNet, TeleGreenland, radios, and personal locator beacons. Program-wide IT and communications limitations are due to the broad categories of bandwidth, availability, and power. At these sites it is essential to conserve bandwidth and power through using efficient software, coding and scheduling techniques. There are interesting new products and services on the horizon that the program may be able to take advantage of in the future such as Iridium NEXT, Inmarsat Xpress, and Omnispace mobile satellite services. Additionally, there are engineering and computer software opportunities to develop more efficient products. We will present an overview of science/engineering partnerships formed by the CPS program, discuss current limitations and identify future technological possibilities that could further advance Arctic science goals.
Ismail, Shariman; Sulaiman, Norasrudin
The proceeding is a collection of research papers presented at the International Colloquium on Sports Science, Exercise, Engineering and Technology (ICoSSEET2014), a conference dedicated to address the challenges in the areas of sports science, exercise, sports engineering and technology including other areas of sports, thereby presenting a consolidated view to the interested researchers in the aforesaid fields. The goal of this conference was to bring together researchers and practitioners from academia and industry to focus on the scope of the conference and establishing new collaborations in these areas. The topics of interest are as follows but are not limited to:1. Sports and Exercise Science • Sports Nutrition • Sports Biomechanics • Strength and Conditioning • Motor Learning and Control • Sports Psychology • Sports Coaching • Sports and Exercise Physiology • Sports Medicine and Athletic Trainer • Fitness and Wellness • Exercise Rehabilitation • Adapted Physical Activity...
Pulkkinen, Antti; Bernabeu, E.; Thomson, A.; Viljanen, A.; Pirjola, R.; Boteler, D.; Eichner, J.; Cilliers, P.J.; Welling, D.; Savani, N.P.; Weigel, R.S.; Love, Jeffrey J.; Balch, Christopher; Ngwira, C.M.; Crowley, G.; Schultz, Adam; Kataoka, R.; Anderson, B.; Fugate, D.; Simpson, J.J.; MacAlester, M.
This paper is the primary deliverable of the very first NASA Living With a Star Institute Working Group, Geomagnetically Induced Currents (GIC) Working Group. The paper provides a broad overview of the current status and future challenges pertaining to the science, engineering, and applications of the GIC problem. Science is understood here as the basic space and Earth sciences research that allows improved understanding and physics-based modeling of the physical processes behind GIC. Engineering, in turn, is understood here as the “impact” aspect of GIC. Applications are understood as the models, tools, and activities that can provide actionable information to entities such as power systems operators for mitigating the effects of GIC and government agencies for managing any potential consequences from GIC impact to critical infrastructure. Applications can be considered the ultimate goal of our GIC work. In assessing the status of the field, we quantify the readiness of various applications in the mitigation context. We use the Applications Readiness Level (ARL) concept to carry out the quantification.
Stem cells carry the promise to cure a broad range of diseases and injuries, from diabetes, heart and muscular diseases, to neurological diseases, disorders and injuries. Significant progresses have been made in stem cell research over the past decade; the derivation of embryonic stem cells (ESCs) from human tissues, the development of cloning technology by somatic cell nuclear transfer (SCNT) and the confirmation that neurogenesis occurs in the adult mammalian brain and that neural stem cells (NSCs) reside in the adult central nervous system (CNS), including that of humans. Despite these advances, there may be decades before stem cell research will translate into therapy. Stem cell research is also subject to ethical and political debates, controversies and legislation, which slow its progress. Cell engineering has proven successful in bringing genetic research to therapy. In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy.
Stem cells carry the promise to cure a broad range of diseases and injuries, from diabetes, heart and muscular diseases, to neurological diseases, disorders and injuries. Significant progresses have been made in stem cell research over the past decade; the derivation of embryonic stem cells (ESCs) from human tissues, the development of cloning technology by somatic cell nuclear transfer (SCNT) and the confirmation that neurogenesis occurs in the adult mammalian brain and that neural stem cells (NSCs) reside in the adult central nervous system (CNS), including that of humans. Despite these advances, there may be decades before stem cell research will translate into therapy. Stem cell research is also subject to ethical and political debates, controversies and legislation, which slow its progress. Cell engineering has proven successful in bringing genetic research to therapy. In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy.
Pace, Diana; Witucki, Laurie; Blumreich, Kathleen
This paper describes the rationale and the step by step process for setting up a WISE (Women in Science and Engineering) learning community at one institution. Background information on challenges for women in science and engineering and the benefits of a learning community for female students in these major areas are described. Authors discuss…
Findeisen, Rolf; Flockerzi, Dietrich; Reichl, Udo; Sundmacher, Kai
This edited volume provides insights into and tools for the modeling, analysis, optimization, and control of large-scale networks in the life sciences and in engineering. Large-scale systems are often the result of networked interactions between a large number of subsystems, and their analysis and control are becoming increasingly important. The chapters of this book present the basic concepts and theoretical foundations of network theory and discuss its applications in different scientific areas such as biochemical reactions, chemical production processes, systems biology, electrical circuits, and mobile agents. The aim is to identify common concepts, to understand the underlying mathematical ideas, and to inspire discussions across the borders of the various disciplines. The book originates from the interdisciplinary summer school “Large Scale Networks in Engineering and Life Sciences” hosted by the International Max Planck Research School Magdeburg, September 26-30, 2011, and will therefore be of int...
Hagstrom, S B
In the last decade of this century and millennium, the computer and communication revolution has shown its power to transform the society. In this talk I will reflect on my personal experience of witnessing this revolution from an observation post in Silicon Valley. In particular, I will emphasize the role of physics and the interplay between science and engineering in this development. Information technology is often viewed as based on some physics discoveries and inventions such as the transistor and the semiconductor laser. Much of the subsequent development, the integrated circuit being a good example, has been an engineering feat. With shrinking dimensions of the circuits we are approaching the quantum limitations, requiring new types of computer architectures based on fundamental physics concepts. In this context we may ask if we should include the basic concepts of information and information handling as part of physics. Finally I will include some remarks on the views of physics as seen in the eyes of...
Robert W. Lingard
Full Text Available To be successful in today's workplace, engineering and computer science students must possess high levels of teamwork skills. Unfortunately, most engineering programs provide little or no specific instruction in this area. This paper outlines an assessment-driven approach toward teaching teamwork skills. Working with the Industrial Advisory Board for the College, a set of performance criteria for teamwork was developed. This set of criteria was used to build an assessment instrument to measure the extent to which students are able to achieve the necessary skills. This set of criteria provides a clear basis for the development of an approach toward teaching teamwork skills. Furthermore, the results from the assessment can be used to adjust the teaching techniques to address the particular skills where students show some weaknesses. Although this effort is in the early stages, the approach seems promising and will be improved over time.
This expansive volume presents the essential topics related to construction materials composition and their practical application in structures and civil installations. The book's diverse slate of expert authors assemble invaluable case examples and performance data on the most important groups of materials used in construction, highlighting aspects such as nomenclature, the properties, the manufacturing processes, the selection criteria, the products/applications, the life cycle and recyclability, and the normalization. Civil Engineering Materials: Science, Processing, and Design is ideal for practicing architects; civil, construction, and structural engineers, and serves as a comprehensive reference for students of these disciplines. This book also: · Provides a substantial and detailed overview of traditional materials used in structures and civil infrastructure · Discusses properties of natural and synthetic materials in construction and materials' manufacturing processes · �...
Kvam, Paul H
A thorough and definitive book that fully addresses traditional and modern-day topics of nonparametric statistics This book presents a practical approach to nonparametric statistical analysis and provides comprehensive coverage of both established and newly developed methods. With the use of MATLAB, the authors present information on theorems and rank tests in an applied fashion, with an emphasis on modern methods in regression and curve fitting, bootstrap confidence intervals, splines, wavelets, empirical likelihood, and goodness-of-fit testing. Nonparametric Statistics with Applications to Science and Engineering begins with succinct coverage of basic results for order statistics, methods of categorical data analysis, nonparametric regression, and curve fitting methods. The authors then focus on nonparametric procedures that are becoming more relevant to engineering researchers and practitioners. The important fundamental materials needed to effectively learn and apply the discussed methods are also provide...
Conejo, Antonio J; Minguez, Roberto; Garcia-Bertrand, Raquel
Optimization plainly dominates the design, planning, operation, and c- trol of engineering systems. This is a book on optimization that considers particular cases of optimization problems, those with a decomposable str- ture that can be advantageously exploited. Those decomposable optimization problems are ubiquitous in engineering and science applications. The book considers problems with both complicating constraints and complicating va- ables, and analyzes linear and nonlinear problems, with and without in- ger variables. The decomposition techniques analyzed include Dantzig-Wolfe, Benders, Lagrangian relaxation, Augmented Lagrangian decomposition, and others. Heuristic techniques are also considered. Additionally, a comprehensive sensitivity analysis for characterizing the solution of optimization problems is carried out. This material is particularly novel and of high practical interest. This book is built based on many clarifying, illustrative, and compu- tional examples, which facilitate the learning p...
Abdullah, M.A; Rahmah, Anisa ur; Sinskey, A.J; Rha, C.K
Biopharmaceuticals are often produced by recombinant E. coli or mammalian cell lines. This is usually achieved by the introduction of a gene or cDNA coding for the protein of interest into a well-characterized strain of producer cells. Naturally, each recombinant production system has its own unique advantages and disadvantages. This paper examines the current practices, developments, and future trends in the production of biopharmaceuticals. Platform technologies for rapid screening and analyses of biosystems are reviewed. Strategies to improve productivity via metabolic and integrated engineering are also highlighted. PMID:19662143
Stefanoiu, Dan; Popescu, Dumitru; Filip, Florin Gheorghe; El Kamel, Abdelkader
The purpose of this book is to present the main metaheuristics and approximate and stochastic methods for optimization of complex systems in Engineering Sciences. It has been written within the framework of the European Union project ERRIC (Empowering Romanian Research on Intelligent Information Technologies), which is funded by the EU's FP7 Research Potential program and has been developed in co-operation between French and Romanian teaching researchers. Through the principles of various proposed algorithms (with additional references) this book allows the reader to explore various methods o
Alt, Franz L
Electronic Digital Computers: Their Use in Science and Engineering describes the principles underlying computer design and operation. This book describes the various applications of computers, the stages involved in using them, and their limitations. The machine is composed of the hardware which is run by a program. This text describes the use of magnetic drum for storage of data and some computing. The functions and components of the computer include automatic control, memory, input of instructions by using punched cards, and output from resulting information. Computers operate by using numbe
Ruan, Ning; Xing, Wenxun; WCGO-III; Advances in Global Optimization
This proceedings volume addresses advances in global optimization—a multidisciplinary research field that deals with the analysis, characterization, and computation of global minima and/or maxima of nonlinear, non-convex, and nonsmooth functions in continuous or discrete forms. The volume contains selected papers from the third biannual World Congress on Global Optimization in Engineering & Science (WCGO), held in the Yellow Mountains, Anhui, China on July 8-12, 2013. The papers fall into eight topical sections: mathematical programming; combinatorial optimization; duality theory; topology optimization; variational inequalities and complementarity problems; numerical optimization; stochastic models and simulation; and complex simulation and supply chain analysis.
Hofmann, D.; Dittrich, P.-G.; Duentsch, E.
Smartphones have an enormous conceptual and structural influence on measurement science & education, instrumentation & training. Smartphones are matured. They became convenient, reliable and affordable. In 2009 worldwide 174 million Smartphones has been delivered. Measurement with Smartphones is ready for the future. In only 10 years the German vision industry tripled its global sales volume to one Billion Euro/Year. Machine vision is used for mobile object identification, contactless industrial quality control, personalized health care, remote facility and transport management, safety critical surveillance and all tasks which are too complex for the human eye or too monotonous for the human brain. Aim of the paper is to describe selected success stories for the application of Smartphones for measurement engineering in science and education, instrumentation and training.
The number of American students entering science and engineering careers and their ranking in comparison with other countries is on the decline. This decline has alarmed Congress which, in 1987, established a Task Force on Women, Minorities, and the Handicapped in Science and Technology to define the problem and find solutions. If left unchanged, the task force has warned that the prospects for maintaining an advanced industrial society will diminish. NASA is supportive of the six goals outlined by the task force, which are paraphrase herein, and is carefully assessing its education programs to identify those offering the greatest potential for achieving the task force objectives with a reasonable range of resources. A major initiative is under way on behalf of NASA at its Marshall Space Flight Center, where highly effective features of several NASA education programs along with innovations are being integrated into a comprehensive pilot program. This program, dubbed Project LASER, is discussed.
Ackerman, T. P.
Climate engineering (or geoengineering) has emerged as a possible component of a strategy to mitigate global warming. This emergence has produced a novel intersection of atmospheric science, environmental ethics and global governance. The scientific questions of climate engineering, while difficult to answer in their own right, are compounded by ethical considerations regarding whether these questions should be addressed and governance questions of how research and deployment could be managed. In an effort to address this intersection of ideas and provide our students with a rich interdisciplinary experience, we (T. Ackerman and S. Gardiner, both senior professors at the University of Washington) taught a cross-listed course in the Atmospheric Sciences and Philosophy departments. The course attracted 12 students (mostly graduate students but with two upper level undergraduates), with roughly equal representation from environmental sciences, ethics, and public policy disciplines, as well as two post-docs. Our primary goal for the course was to develop a functioning research community to address the core issues at the intersection of science and ethics. In this presentation, we discuss the course structure, identify strategies that were successful (or less so), and describe outcomes. We consider this course to be primarily pedagogical in nature, but we also recognize that many of the students in the class, perhaps even a majority, are intending to pursue careers outside academia in areas of public policy, environmental consulting, etc., which added an extra dimension to our class. Here, we also discuss the possibility of developing and teaching such courses in an academic environment that is stressed financially and increasingly dependent on metrics related to class size and student credit hours.
Lesko, Kevin T.
The National Science Foundation and the international underground science community are well into establishing a world-class, multidisciplinary Deep Underground Science and Engineering Laboratory (DUSEL) at the former Homestake mine in Lead South Dakota. The NSF's review committee, following the first two NSF solicitations, selected the Homestake Proposal and site as the prime location to be developed into an international research facility. Homestake DUSEL will provide much needed underground research space to help relieve the worldwide shortage, particularly at great depth, and will develop research campuses at several different depths to satisfy the research requirements for the coming decades. The State of South Dakota has demonstrated remarkable support for the project and has secured the site with the transfer from the Homestake Mining Corp. The State, through its Science and Technology Authority with state funds and those of a philanthropic donor has initiated rehabilitation of the surface and underground infrastructure including the Ross and Yates hoists accessing the 4850 Level (feet below ground, 4100 to 4200 mwe). The scientific case for DUSEL and the progress in establishing the preliminary design of the facility and the associated suite of experiments to be funded along with the facility by the NSF are presented.
Soto, Delia A; Ross, Pablo J
The unlimited proliferative ability and capacity to contribute to germline chimeras make pluripotent embryonic stem cells (ESCs) perfect candidates for complex genetic engineering. The utility of ESCs is best exemplified by the numerous genetic models that have been developed in mice, for which such cells are readily available. However, the traditional systems for mouse genetic engineering may not be practical for livestock species, as it requires several generations of mating and selection in order to establish homozygous founders. Nevertheless, the self-renewal and pluripotent characteristics of ESCs could provide advantages for livestock genetic engineering such as ease of genetic manipulation and improved efficiency of cloning by nuclear transplantation. These advantages have resulted in many attempts to isolate livestock ESCs, yet it has been generally concluded that the culture conditions tested so far are not supportive of livestock ESCs self-renewal and proliferation. In contrast, there are numerous reports of derivation of livestock induced pluripotent stem cells (iPSCs), with demonstrated capacity for long term proliferation and in vivo pluripotency, as indicated by teratoma formation assay. However, to what extent these iPSCs represent fully reprogrammed PSCs remains controversial, as most livestock iPSCs depend on continuous expression of reprogramming factors. Moreover, germline chimerism has not been robustly demonstrated, with only one successful report with very low efficiency. Therefore, even 34 years after derivation of mouse ESCs and their extensive use in the generation of genetic models, the livestock genetic engineering field can stand to gain enormously from continued investigations into the derivation and application of ESCs and iPSCs.
Waltman, L.R.; Van, Raan A.F.J.; Smart, S.
We investigate the extent to which advances in the health and life sciences (HLS) are dependent on research in the engineering and physical sciences (EPS), particularly physics, chemistry, mathematics, and engineering. The analysis combines two different bibliometric approaches. The first approach
Full Text Available Trehalose is a naturally occurring disaccharide which is associated with extraordinary stress-tolerance capacity in certain species of unicellular and multicellular organisms. In mammalian cells, presence of intra- and extracellular trehalose has been shown to confer improved tolerance against freezing and desiccation. Since mammalian cells do not synthesize nor import trehalose, the development of novel methods for efficient intracellular delivery of trehalose has been an ongoing investigation. Herein, we studied the membrane permeability of engineered lipophilic derivatives of trehalose. Trehalose conjugated with 6 acetyl groups (trehalose hexaacetate or 6-O-Ac-Tre demonstrated superior permeability in rat hepatocytes compared with regular trehalose, trehalose diacetate (2-O-Ac-Tre and trehalose tetraacetate (4-O-Ac-Tre. Once in the cell, intracellular esterases hydrolyzed the 6-O-Ac-Tre molecules, releasing free trehalose into the cytoplasm. The total concentration of intracellular trehalose (plus acetylated variants reached as high as 10 fold the extracellular concentration of 6-O-Ac-Tre, attaining concentrations suitable for applications in biopreservation. To describe this accumulation phenomenon, a diffusion-reaction model was proposed and the permeability and reaction kinetics of 6-O-Ac-Tre were determined by fitting to experimental data. Further studies suggested that the impact of the loading and the presence of intracellular trehalose on cellular viability and function were negligible. Engineering of trehalose chemical structure rather than manipulating the cell, is an innocuous, cell-friendly method for trehalose delivery, with demonstrated potential for trehalose loading in different types of cells and cell lines, and can facilitate the wide-spread application of trehalose as an intracellular protective agent in biopreservation studies.
Class, Holger; Kissinger, Alexander; Knopf, Stefan; Konrad, Wilfried; Noack, Vera; Scheer, Dirk
The modeling of flow and transport processes in the context of engineering in the subsurface often takes place within a field of conflict from different interests, where societal issues are touched or involved. Carbon Capture and Storage, Fracking, or nuclear waste disposal are just a few prominent examples, where engineering (or: natural sciences) and social sciences have a common field of research. It is only consequent for both disciplines to explore methods and tools to achieve best possible mutual benefits. Participatory modeling (PM) is such an idea, where so-called stakeholders can be involved during different phases of the modeling process. This can be accomplished by very different methods of participation and for different reasons (public acceptance, public awareness, transparency, improved understanding through collective learning, etc). Therefore, PM is a generic approach, open for different methods to be used in order to facilitate early expert and stakeholder integration in science development. We have used PM recently in two examples, both in the context of Carbon Capture and Storage. The first one addressed the development and evaluation (by stakeholders) of a screening criterion for site selection. The second one deals with a regional-scale brine migration scenario where stakeholders have been involved in evaluating the general importance of brine migration, the design of a representative geological model for a case study and in the definition of scenarios to be simulated. This contribution aims at summarizing our experiences and share it with the modeling community. References: A Kissinger, V Noack, S Knopf, D Scheer, W Konrad, H Class Characterization of reservoir conditions for CO2 storage using a dimensionless gravitational number applied to the North German Basin, Sustainable Energy Technologies and Assessments 7, 209-220, 2014 D Scheer, W Konrad, H Class, A Kissinger, S Knopf, V Noack Expert involvement in science development: (re
The American Indian Science and Engineering Society (AISES) has been funded under a U.S. Department of Energy (DOE) grant (Grant Award No. DE-SC0004058) to host an Intertribal Middle-School Science and Math Bowl (IMSSMB) comprised of teams made up of a majority of American Indian students from Bureau of Indian Education-funded schools and public schools. The intent of the AISES middle school science and math bowl is to increase participation of American Indian students at the DOE-sponsored National Science Bowl. Although national in its recruitment scope, the AISES Intertribal Science and Math Bowl is considered a “regional” science bowl, equivalent to the other 50 regional science bowls which are geographically limited to states. Most regional bowls do not have American Indian student teams competing, hence the AISES bowl is meant to encourage American Indian student teams to increase their science knowledge in order to participate at the national level. The AISES competition brings together teams from various American Indian communities across the nation. Each team is provided with funds for travel to and from the event, as well as for lodging and meals. In 2011 and 2012, there were 10 teams participating; in 2013, the number of teams participating doubled to 20. Each Science and Math Bowl team is comprised of four middle school — grades 6 through 8 — students, one alternate, and a teacher who serves as advisor and coach — although in at least two cases, the coach was not a teacher, but was the Indian Education Coordinator. Each team member must have at least a 3.0 GPA. Furthermore, the majority of students in each team must be comprised of American Indian, Alaska Native or Native Hawaiian students. Under the current DOE grant, AISES sponsored three annual middle school science bowl competitions over the years 2011, 2012 and 2013. The science and math bowls have been held in late March concurrently with the National American Indian Science and
... TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee of the Committee on Technology, National Science and Technology Council Workshop ACTION: Notice of public meeting. SUMMARY: The National Nanotechnology Coordination Office (NNCO), on behalf of the Nanoscale Science, Engineering, and Technology (NSET...
In order to deal with the complexity of biological systems and attempts to generate applicable results, current biomedical sciences are adopting concepts and methods from the engineering sciences. Philosophers of science have interpreted this as the emergence of an engineering paradigm, in
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This Proceedings Volume includes the technical papers that were presented during the Fifteenth Symposium on Energy Engineering Sciences on May 14-15, 1997, at Argonne National Laboratory, Argonne, Illinois. The Symposium was organized into eight technical sessions, which included 32 individual presentations followed by discussion and interaction with the audience. The topics of the eight sessions are: multiphase flows 1; multiphase flows 2; mostly optics; fluid mechanics; nonlinear fields; welding and cracks; materials; and controls. The DOE Office of Basic Energy Sciences, of which Engineering Research is a component program, is responsible for the long-term mission-oriented research in the Department. It has the prime responsibility for establishing the basic scientific foundation upon which the Nation`s future energy options will have to be identified, developed, and built. It is committed to the generation of new knowledge necessary for the solution of present and future problems of energy exploration, production, conversion, and utilization, consistent with respect for the environment. Separate abstracts have been indexed into the energy database for contributions to this Symposium.
Choi, Angie Nim
Two waves of data from the 2006 and 2008 Survey of Earned Doctorates and Survey of Doctorate Recipients were used in this study to investigate time to doctorate (TTD) and time to career (TTC) for science and engineering PhDs. Three-way factorial ANOVAs were conducted, and TTD results indicated main effects for gender, US citizenship, and Biglan classification, and interaction effects for gender and US citizenship. US citizen PhDs progressed to their career approximately one mean year faster than foreign PhDs. For TTC, PhDs who held postdocs progressed to their careers in 14 and 15 years for females and males respectively compared to 19 years for those without postdoctoral appointments. PhDs working in academe also had shorter TTC rates than those working in industry or government settings. TTC rates were lowest for PhDs from engineering fields and highest for those from health sciences. A multiple linear regression based upon the 2006 data was also used to determine the best predictors of TTC based upon individual, academic, and employer characteristics, and the model was cross-validated with an independent sample from the 2008 data. The regression solution was significant, F (20, 11000) = 97.06, p effect size (R2 = .14), and the cross-validated model had a slightly higher effect (R2 = .28).
Srivastava, Shivani; Riddell, Stanley R
Despite being empirically designed based on a simple understanding of TCR signaling, T cells engineered with chimeric antigen receptors (CARs) have been remarkably successful in treating patients with advanced refractory B cell malignancies. However, many challenges remain in improving the safety and efficacy of this therapy and extending it toward the treatment of epithelial cancers. Other aspects of TCR signaling beyond those directly provided by CD3ζ and CD28 phosphorylation strongly influence a T cell's ability to differentiate and acquire full effector functions. Here, we discuss how the principles of TCR recognition, including spatial constraints, Kon/Koff rates, and synapse formation, along with in-depth analysis of CAR signaling might be applied to develop safer and more effective synthetic tumor targeting receptors. Copyright © 2015 Elsevier Ltd. All rights reserved.
Ma, Quanquan; Liao, Jinfeng; Cai, Xiaoxiao
The articular cartilage is unique in that it contains only a single type of cell and shows poor ability for spontaneous healing. Currently, approaches for treating cartilage defects include surgical and nonsurgical approaches, as well as cartilage tissue engineering. For standard cartilage tissue engineering, three elements are required, i.e., a scaffold, growth factors, and seed cells. With advancements in in stem cell research, the main sources of cells for cartilage tissue engineering are embryonic and mesenchymal stem cells, which have been shown to be promising alternatives in recent years. In this review, we focus on applications of various stem cells in cartilage tissue engineering. Under certain conditions, several types of stem cells, including embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, and cartilage progenitor cells, showed potential for applications in chondrogenic differentiation. Stem cells can be developed as important cell sources for cartilage tissue engineering if appropriate microenvironments and bioactive factors are supplied. However, further studies are needed to determine the ideal cell type for cartilage repair, particularly using in vivo and clinical studies. Copyright© Bentham Science Publishers; For any queries, please email at firstname.lastname@example.org.
Boice, D. C.; Asbell, H. E.; Reiff, P. H.
Young Engineers and Scientists (YES) is a community partnership between Southwest Research Institute (SwRI), and local high schools in San Antonio, Texas (USA). YES has been highly successful during the past 15 years and YES 2K7 continued this trend. The YES program provides talented high school juniors and seniors a bridge between classroom instruction and real world, research experiences in physical sciences (including space science and astronomy) and engineering. YES consists of two parts: 1) an intensive three-week summer workshop held at SwRI where students experience the research environment first-hand; develop skills and acquire tools for solving scientific problems, attend mini-courses and seminars on electronics, computers and the Internet, careers, science ethics, and other topics; and select individual research projects to be completed during the academic year; and 2) a collegial mentorship where students complete individual research projects under the guidance of their mentors during the academic year and earn honors credit. At the end of the school year, students publicly present and display their work, acknowledging their accomplishments and spreading career awareness to other students and teachers. YES 2K7 developed a website for the Magnetospheric Multiscale Mission (MMS) from the perspective of 20 high school students (yesserver.space.swri.edu). Over the past 15 years, all YES graduates have entered college, several have worked for SwRI, and three scientific publications have resulted. Student evaluations indicate the effectiveness of YES on their academic preparation and choice of college majors. Acknowledgements: We acknowledge funding and support from the NASA MMS Mission, SwRI, Northside Independent School District, and local charitable foundations.
This book includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Informatics, and Systems Sciences, and Engineering. It includes selected papers form the conference proceedings of the Ninth International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering (CISSE 2013). Coverage includes topics in: Industrial Electronics, Technology & Automation, Telecommunications and Networking, Systems, Computing Sciences and Software Engineering, Engineering Education, Instructional Technology, Assessment, and E-learning. • Provides the latest in a series of books growing out of the International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering; • Includes chapters in the most advanced areas of Computing, Informatics, Systems Sciences, and Engineering; • Accessible to a wide range of readership, including professors, researchers, practitioners and...
Innovations and Advances in Computing, Informatics, Systems Sciences, Networking and Engineering This book includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Informatics, and Systems Sciences, and Engineering. It includes selected papers from the conference proceedings of the Eighth and some selected papers of the Ninth International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering (CISSE 2012 & CISSE 2013). Coverage includes topics in: Industrial Electronics, Technology & Automation, Telecommunications and Networking, Systems, Computing Sciences and Software Engineering, Engineering Education, Instructional Technology, Assessment, and E-learning. · Provides the latest in a series of books growing out of the International Joint Conferences on Computer, Information, and Systems Sciences, and Engineering; · Includes chapters in the most a...
Ludo Waltman; van Raan, Anthony F. J.; Sue Smart
We investigate the extent to which advances in the health and life sciences (HLS) are dependent on research in the engineering and physical sciences (EPS), particularly physics, chemistry, mathematics, and engineering. The analysis combines two different bibliometric approaches. The first approach to analyze the 'EPS-HLS interface' is based on term map visualizations of HLS research fields. We consider 16 clinical fields and five life science fields. On the basis of expert judgment, EPS resea...
Mackay, Steven D.
Yang Cao, an assistant professor in the computer science department at Virginia Tech's College of Engineering, has won a $550,000 National Science Foundation Faculty Early Career Development (CAREER) award to develop computer simulation methods that will better understand the complex, discrete, and stochastic cell cycle model.
Ferguson, Andrew L.
In many branches of materials science it is now routine to generate data sets of such large size and dimensionality that conventional methods of analysis fail. Paradigms and tools from data science and machine learning can provide scalable approaches to identify and extract trends and patterns within voluminous data sets, perform guided traversals of high-dimensional phase spaces, and furnish data-driven strategies for inverse materials design. This topical review provides an accessible introduction to machine learning tools in the context of soft and biological materials by ‘de-jargonizing’ data science terminology, presenting a taxonomy of machine learning techniques, and surveying the mathematical underpinnings and software implementations of popular tools, including principal component analysis, independent component analysis, diffusion maps, support vector machines, and relative entropy. We present illustrative examples of machine learning applications in soft matter, including inverse design of self-assembling materials, nonlinear learning of protein folding landscapes, high-throughput antimicrobial peptide design, and data-driven materials design engines. We close with an outlook on the challenges and opportunities for the field.
In many branches of materials science it is now routine to generate data sets of such large size and dimensionality that conventional methods of analysis fail. Paradigms and tools from data science and machine learning can provide scalable approaches to identify and extract trends and patterns within voluminous data sets, perform guided traversals of high-dimensional phase spaces, and furnish data-driven strategies for inverse materials design. This topical review provides an accessible introduction to machine learning tools in the context of soft and biological materials by ``de-jargonizing'' data science terminology, presenting a taxonomy of machine learning techniques, and surveying the mathematical underpinnings and software implementations of popular tools, including principal component analysis, independent component analysis, diffusion maps, support vector machines, and relative entropy. We present illustrative examples of machine learning applications in soft matter, including inverse design of self-assembling materials, nonlinear learning of protein folding landscapes, high-throughput antimicrobial peptide design, and data-driven materials design engines. We close with an outlook on the challenges and opportunities for the field. © 2017 IOP Publishing Ltd.
Dudley, Quentin M; Karim, Ashty S; Jewett, Michael C
Industrial biotechnology and microbial metabolic engineering are poised to help meet the growing demand for sustainable, low-cost commodity chemicals and natural products, yet the fraction of biochemicals amenable to commercial production remains limited. Common problems afflicting the current state-of-the-art include low volumetric productivities, build-up of toxic intermediates or products, and byproduct losses via competing pathways. To overcome these limitations, cell-free metabolic engineering (CFME) is expanding the scope of the traditional bioengineering model by using in vitro ensembles of catalytic proteins prepared from purified enzymes or crude lysates of cells for the production of target products. In recent years, the unprecedented level of control and freedom of design, relative to in vivo systems, has inspired the development of engineering foundations for cell-free systems. These efforts have led to activation of long enzymatic pathways (>8 enzymes), near theoretical conversion yields, productivities greater than 100 mg L(-1) h(-1) , reaction scales of >100 L, and new directions in protein purification, spatial organization, and enzyme stability. In the coming years, CFME will offer exciting opportunities to: (i) debug and optimize biosynthetic pathways; (ii) carry out design-build-test iterations without re-engineering organisms; and (iii) perform molecular transformations when bioconversion yields, productivities, or cellular toxicity limit commercial feasibility. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
This book describes a revolution in software engineering - the Nonlinear Software Engineering paradigm, which complies with the essential principles of complexity science and can help double productivity, halve costs and reduce defects in software products.
Babuska, Ivo; Oden, Tinsley
Computational engineering and science, the discipline concerned with the use of computational methods and devices to simulate physical events and engineering systems, is being heralded by many as one...
Vanderoost, Jef; Van Soom, Carolien; Langie, Greet; Van den Bossche, Johan; Callens, Riet; Vandewalle, Joos; De Laet, Tinne
A new battery of positioning tests for Science and Engineering was broadly implemented in Flanders in the summer of 2013. The goal of the non-mandatory and non-binding positioning test is to allow future students, with a clear choice for engineering or science, to position themselves with respect to the required prior knowledge and skills and to stimulate students to participate in a remediation program if necessary. For each engineering or science bachelor under study, a specific position...
Ing, Marsha; Aschbacher, Pamela R; Tsai, Sherry M
This longitudinal study analyzes survey responses in seventh, eighth, and ninth grade from diverse public school students (n = 482) to explore gender differences in engineering and science career preferences. Females were far more likely to express interest in a science career (31%) than an engineering career (13%), while the reverse was true for males (58% in engineering, 39% in science). After controlling for student and school demographic characteristics, females were as consistent as male...
Laurencin, Cato T; Freeman, Joseph W
The anterior cruciate ligament (ACL) is important for knee stabilization. Unfortunately, it is also the most commonly injured intra-articular ligament. Due to poor vascularization, the ACL has inferior healing capability and is usually replaced after significant damage has occurred. Currently available replacements have a host of limitations, this has prompted the search for tissue-engineered solutions for ACL repair. Presently investigated scaffolds range from twisted fiber architectures composed of silk fibers to complex three-dimensional braided structures composed of poly (L-lactic acid) fibers. The purpose of these tissue-engineered constructs is to apply approaches such as the use of porous scaffolds, use of cells, and the application of growth factors to promote ligament tissue regeneration while providing mechanical properties similar to natural ligament.
The National Research Council developed and published the "Framework for K-12 Science Education," a new set of concepts that many states were planning on adopting. Part of this new endeavor included a set of science and engineering crosscutting concepts to be incorporated into science materials and activities, a first in science…
Committee on Women in Science, Engineering, and Medicine; Policy and Global Affairs; Committee on National Statistics; Division of Behavioral and Social Sciences and Education; National Research Council; National Research Council
"Gender Differences at Critical Transitions in the Careers of Science, Engineering, and Mathematics Faculty presents new and surprising findings about career differences between female and male full...
This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, fluid mechanics, and computer science during the period 1 Oct. 1996 - 31 Mar. 1997.
Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April 1, 1985 through October 2, 1985 is summarized.
This report summarizes research conducted at the Institute for Computer Applications Science and Engineering in applied mathematics, numerical analysis, and computer science during the period October 2, 1987 through March 31, 1988.
This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April 1, 1987 through October 1, 1987.
Bi, Xiaobao; Yin, Juan; Chen Guanbang, Ashley; Liu, Chuan-Fa
Cell surface serves important functions such as the regulation of cell-cell and cell-environment interactions. The understanding and manipulation of the cell surface is important for a wide range of fundamental studies of cellular behavior and for biotechnological and medical applications. With the rapid advance of biology, chemistry and materials science, many strategies have been developed for the functionalization of bacterial and mammalian cell surfaces. Here, we review the recent development of chemical and enzymatic approaches to cell surface engineering with particular emphasis on discussing the advantages and limitations of each of these strategies. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Rondoni, Lamberto; Mitra, Mala
Chaos and nonlinear dynamics initially developed as a new emergent field with its foundation in physics and applied mathematics. The highly generic, interdisciplinary quality of the insights gained in the last few decades has spawned myriad applications in almost all branches of science and technology—and even well beyond. Wherever the quantitative modeling and analysis of complex, nonlinear phenomena are required, chaos theory and its methods can play a key role. This second volume concentrates on reviewing further relevant, contemporary applications of chaotic nonlinear systems as they apply to the various cutting-edge branches of engineering. This encompasses, but is not limited to, topics such as the spread of epidemics; electronic circuits; chaos control in mechanical devices; secure communication; and digital watermarking. Featuring contributions from active and leading research groups, this collection is ideal both as a reference work and as a ‘recipe book’ full of tried and tested, successf...
Berger, Paul D; Celli, Giovana B
This text introduces and provides instruction on the design and analysis of experiments for a broad audience. Formed by decades of teaching, consulting, and industrial experience in the Design of Experiments field, this new edition contains updated examples, exercises, and situations covering the science and engineering practice. This text minimizes the amount of mathematical detail, while still doing full justice to the mathematical rigor of the presentation and the precision of statements, making the text accessible for those who have little experience with design of experiments and who need some practical advice on using such designs to solve day-to-day problems. Additionally, an intuitive understanding of the principles is always emphasized, with helpful hints throughout.
Renk, Karl F
This textbook provides an introductory presentation of all types of lasers. It contains a general description of the laser, a theoretical treatment and a characterization of its operation as it deals with gas, solid state, free-electron and semiconductor lasers. This expanded and updated second edition of the book presents a description of the dynamics of free-electron laser oscillation using a model introduced in the first edition that allows a reader to understand basic properties of a free-electron laser and makes the difference to “conventional” lasers. The discussions and the treatment of equations are presented in a way that a reader can immediately follow. The book addresses graduate and undergraduate students in science and engineering, featuring problems with solutions and over 400 illustrations.
Amos O. Olagunju
Full Text Available Ask the graduates and the employers of graduates of computing information sciences and engineering (CISE one area in which more formal training would have been beneficial while still in college. It is not surprising that both the employers and the graduates often agree that students require more training in discipline-specific soft skills (DSSS in CISE. Yet, the requirements for undergraduate DSSS in CISE remain an open subject for debate. Should all undergraduate core courses be revised to incorporate DSSS requirements? Should DSSS be designed for infusion into the technical core courses for undergraduates in CISE? How should student learning outcomes (SLOs for DSSS be defined and assessed? This paper discusses these and further questions.
Kleinman, Sharon S.
This article explores the constructs of online community and online social support and discusses a naturalistic case study of a public, unmoderated, online discussion group dedicated to issues of interest to women in science and engineering. The benefits of affiliation with OURNET (a pseudonym) were explored through participant observation over a 4-year period, telephone interviews with 21 subscribers, and content analysis of e-mail messages posted to the discussion group during a 125-day period. The case study findings indicated that through affiliation with the online discussion group, women in traditionally male-dominated fields expanded their professional networks, increased their knowledge, constituted and validated positive social identities, bolstered their self-confidence, obtained social support and information from people with a wide range of experiences and areas of expertise, and, most significantly, found community.
... Doc No: 2012-22676] OFFICE OF SCIENCE AND TECHNOLOGY POLICY Nanoscale Science, Engineering, and Technology Subcommittee; Committee on Technology, National Science and Technology Council; Public Engagement Through Nano.gov Webinar AGENCY: Executive Office of the President, Office of Science and Technology...
Mihelcic, James R; Crittenden, John C; Small, Mitchell J; Shonnard, David R; Hokanson, David R; Zhang, Qiong; Chen, Hui; Sorby, Sheryl A; James, Valentine U; Sutherland, John W; Schnoor, Jerald L
A case is made for growth of a new metadiscipline of sustainability science and engineering. This new field integrates industrial, social, and environmental processes in a global context. The skills required for this higher level discipline represent a metadisciplinary endeavor, combining information and insights across multiple disciplines and perspectives with the common goal of achieving a desired balance among economic, environmental, and societal objectives. Skills and capabilities that are required to support the new metadiscipline are summarized. Examples of integrative projects are discussed in the areas of sustainability metrics and integration of industrial, societal, and environmental impacts. It is clear that a focus on green engineering that employs pollution prevention and industrial ecology alone are not sufficient to achieve sustainability, because even systems with efficient material and energy use can overwhelm the carrying capacity of a region or lead to other socially unacceptable outcomes. To meet the educational and human resource needs required for this new discipline, the technological and environmental awareness of society must be elevated and a sufficient and diverse pool of human talent must be attracted to this discipline.
Weatherwax, A. T.; Fitzsimmons, Z.; Czajkowski, J.; Breimer, E.; Hellman, S. B.; Hunter, S.; Dematteo, J.; Savery, T.; Melsert, K.; Sneeringer, J.
The increased popularity of mobile phone apps provide scientists with a new avenue for sharing and distributing data and knowledge with colleagues, while also providing meaningful education and outreach products for consumption by the general public. Our initial development of iPhone and Android apps centered on the distribution of exciting auroral images taken at the South Pole for education and outreach purposes. These portable platforms, with limited resources when compared to computers, presented a unique set of design and implementation challenges that we will discuss in this presentation. For example, the design must account for limited memory; screen size; processing power; battery life; and potentially high data transport costs. Some of these unique requirements created an environment that enabled undergraduate and high-school students to participate in the creation of these apps. Additionally, during development it became apparent that these apps could also serve as data analysis and engineering tools. Our presentation will further discuss our plans to use apps not only for Education and Public Outreach, but for teaching, science and engineering.
Baxter, Kathleen B.
As a result of the underrepresentation of women in science and engineering programs, the culture is male-dominated and perpetuates an unsupportive and biased climate that discourages undergraduate women from connecting to their gender. Using a social identity framework, this study addresses how gender influences undergraduate women's perception of themselves, their role in the engineering community and their decision to persist. By capturing the experiences of 16 undergraduate women who are enrolled at two elite technical universities in Southern California, this qualitative study utilizes focus groups and individual interviews to provide key insight and perspective on the role of gender in their experience. Through the data, we learn perception has a significant impact on women, that women are willing to acclimate to a masculine culture as a means to both prove legitimacy and feel a sense of belonging and lastly, women manage their gender in two primary ways, one by integrating within the culture through adopting more masculine tendencies and second, by adapting to the environment as needed and persevering in spite of the masculine undercurrent. The implications at the conclusion of this study are two-fold. One focus is helping undergraduate women understand gendered experiences and bringing gender to the forefront of their experience and the second is studying the overall structure of this culture in an effort to move from a masculine, gender-neutral philosophy to one that is gender-sensitive and gender-inclusive.
Li, Jinghai; Wang, Wei; Yang, Ning; Liu, Xinhua; Wang, Limin; He, Xianfeng; Wang, Xiaowei; Wang, Junwu; Kwauk, Mooson
Multiscale modeling is becoming essential for accurate, rapid simulation in science and engineering. This book presents the results of three decades of research on multiscale modeling in process engineering from principles to application, and its generalization for different fields. This book considers the universality of meso-scale phenomena for the first time, and provides insight into the emerging discipline that unifies them, meso-science, as well as new perspectives for virtual process engineering. Multiscale modeling is applied in areas including: multiphase flow and fluid dynamics chemical, biochemical and process engineering mineral processing and metallurgical engineering energy and resources materials science and engineering Jinghai Li is Vice-President of the Chinese Academy of Sciences (CAS), a professor at the Institute of Process Engineering, CAS, and leader of the EMMS (Energy-minimization multiscale) Group. Wei Ge, Wei Wang, Ning Yang and Junwu Wang are professors at the EMMS Group, part of th...
Wilson, John Tanner
Islet transplantation has emerged as a promising cell-based therapy for the treatment of diabetes, but its clinical efficacy remains limited by deleterious host responses that underlie islet destruction. In this dissertation, we describe the assembly of ultrathin conformal coatings that confer molecular-level control over the composition and biophysicochemical properties of the islet surface with implications for improving islet engraftment. Significantly, this work provides novel biomolecular strategies for cell surface engineering with broad biomedical and biotechnological applications in cell-based therapeutics and beyond. Encapsulation of cells and tissue offers a rational approach for attenuating deleterious host responses towards transplanted cells, but a need exists to develop cell encapsulation strategies that minimize transplant volume. Towards this end, we endeavored to generate nanothin films of diverse architecture with tunable properties on the extracellular surface of individual pancreatic islets through a process of layer-by-layer (LbL) self assembly. We first describe the formation of poly(ethylene glycol) (PEG)-rich conformal coatings on islets via LbL self assembly of poly(L-lysine)-g-PEG(biotin) and streptavidin. Multilayer thin films conformed to the geometrically and chemically heterogeneous islet surface, and could be assembled without loss of islet viability or function. Significantly, coated islets performed comparably to untreated controls in a murine model of allogenic intraportal islet transplantation, and, to our knowledge, this is the first study to report in vivo survival and function of nanoencapsulated cells or cell aggregates. Based on these findings, we next postulated that structurally similar PLL-g-PEG copolymers comprised of shorter PEG grafts might be used to initiate and propagate the assembly of polyelectrolyte multilayer (PEM) films on pancreatic islets, while simultaneously preserving islet viability. Through control of PLL
Tang, Wendy; Westgate, Charles; Liu, Pao-Lo; Gouzman, Michael
The Online Bachelor of Science in Electrical Engineering is a collaborative effort among three University Centers at SUNY (State University of New York), namely Stony Brook, Binghamton, and Buffalo. The program delivers the complete electrical engineering curriculum at the bachelor level to students online and asynchronously. Students, however,…
Xu, Can; Hu, Shuo; Chen, Xiaoyuan
Artificial cells have attracted much attention as substitutes for natural cells. There are many different forms of artificial cells with many different definitions. They can be integral biological cell imitators with cell-like structures and exhibit some of the key characteristics of living cells. Alternatively, they can be engineered materials that only mimic some of the properties of cells, such as surface characteristics, shapes, morphology, or a few specific functions. These artificial cells can have applications in many fields from medicine to environment, and may be useful in constructing the theory of the origin of life. However, even the simplest unicellular organisms are extremely complex and synthesis of living artificial cells from inanimate components seems very daunting. Nevertheless, recent progress in the formulation of artificial cells ranging from simple protocells and synthetic cells to cell-mimic particles, suggests that the construction of living life is now not an unrealistic goal. This review aims to provide a comprehensive summary of the latest developments in the construction and application of artificial cells, as well as highlight the current problems, limitations, challenges and opportunities in this field.
Naderi, Hojjat; Matin, Maryam M; Bahrami, Ahmad Reza
Tissue engineering is a newly emerging biomedical technology, which aids and increases the repair and regeneration of deficient and injured tissues. It employs the principles from the fields of materials science, cell biology, transplantation, and engineering in an effort to treat or replace damaged tissues. Tissue engineering and development of complex tissues or organs, such as heart, muscle, kidney, liver, and lung, are still a distant milestone in twenty-first century. Generally, there are four main challenges in tissue engineering which need optimization. These include biomaterials, cell sources, vascularization of engineered tissues, and design of drug delivery systems. Biomaterials and cell sources should be specific for the engineering of each tissue or organ. On the other hand, angiogenesis is required not only for the treatment of a variety of ischemic conditions, but it is also a critical component of virtually all tissue-engineering strategies. Therefore, controlling the dose, location, and duration of releasing angiogenic factors via polymeric delivery systems, in order to ultimately better mimic the stem cell niche through scaffolds, will dictate the utility of a variety of biomaterials in tissue regeneration. This review focuses on the use of polymeric vehicles that are made of synthetic and/or natural biomaterials as scaffolds for three-dimensional cell cultures and for locally delivering the inductive growth factors in various formats to provide a method of controlled, localized delivery for the desired time frame and for vascularized tissue-engineering therapies.
Convergence of the life sciences with fields including physical, chemical, mathematical, computational, engineering, and social sciences is a key strategy to tackle complex challenges and achieve new and innovative solutions. However, institutions face a lack of guidance on how to establish effective programs, what challenges they are likely to encounter, and what strategies other organizations have used to address the issues that arise. This advice is needed to harness the excitement generated by the concept of convergence and channel it into the policies, structures, and networks that will enable it to realize its goals. Convergence investigates examples of organizations that have established mechanisms to support convergent research. This report discusses details of current programs, how organizations have chosen to measure success, and what has worked and not worked in varied settings. The report summarizes the lessons learned and provides organizations with strategies to tackle practical needs and imple...
Hamilton, Robert V.
This dissertation analyzes the nearly 100,000 foreign students who attained science and engineering (S&E) doctorates in the five fields of physical sciences, life sciences, engineering, mathematics and computer sciences, and social and behavioral sciences at American universities from 1994 to 2005. Two models are presented. In the first model controlling for population, multivariate regression results testing for whether foreign students from higher or lower income nations (181 nations) tended to attain S&E doctorates showed that certain S&E fields tended to be represented by students from higher income nations early in the time period (e.g. 1994 to 1999) but the national income variable explaining foreign S&E doctoral attainment was not statistically significant in four of the fields after the year 2000. Four nations, China, India, South Korea and Taiwan stand out due to their large S&E doctoral student presence at American universities, but virtually all growth in foreign doctoral attainment in four of the S&E fields from 1994 to 2005 came from Chinese students, and this growth was most pronounced after the year 2001. In short, whereas the foreign student populations from South Korea and Taiwan were the outliers in 1994 and as such skewed testing results, they had largely been displaced in 2005 by the increased presence of Chinese students. From the US public policy perspective, to the extent that growth in foreign S&E doctoral attainment is an issue to include its related costs and benefits, the appropriate policy focus should shift more specifically towards the growth in Chinese S&E doctoral attainment. Further, with the exception of China and India, foreign doctoral students from the lowest income nations of the world in all five S&E fields were greatly under represented on American campuses from 1994 to 2005. Testing results from the second model complement the findings in the first model. Whereas the first model tested for the effects of national income on
Lucena, Juan C.
This is a cultural history of the creation of women and minorities in science and engineering as a statistical category in the United States. The main thesis is that narratives about the nation, its problems, and its solutions, shape policies and programs for the education and training of scientists and engineers, as well as the meaning of the category women and minorities in science and engineering. This cultural relationship among nation, policy, and statistical categories has been evident in the development of programs for education and human resources at the National Science Foundation (NSF). Power struggles and social negotiations surrounding NSF programs define national solutions in terms of scientists and engineers, and create the category women and minorities in science and engineering. During the last 3 decades different groups have used a variety of strategies in their attempts to participate in the policy-making processes that determine both their access to science and engineering education and their acceptance as scientists and engineers. This is a brief history, from the 1970s to the present, of how these struggles resulted in programs at the NSF to recruit, educate, and retain women and minorities in science and engineering in appropriate ways, where what is appropriate changes over time. This cultural and historical process is called making women and minorities in science and engineering for national purposes.
Conrad, Sarah; Canetto, Silvia Sara; MacPhee, David; Farro, Samantha
Socioeconomically disadvantaged (SED) students are less likely to major in physical sciences or engineering. To guide recruitment and retention of a diversity of talent, this study examined what attracts high-achieving SED students to these fields. Participants were 50 undergraduates majoring in physical sciences or engineering enrolled in the…
Dare, Emily A.; Ellis, Joshua A.; Roehrig, Gillian H.
It is difficult to ignore the increased use of technological innovations in today's world, which has led to various calls for the integration of engineering into K-12 science standards. The need to understand how engineering is currently being brought to science classrooms is apparent and necessary in order to address these calls for integration.…
National Science Foundation, Arlington, VA. Div. of Science Resources Statistics.
This report is the 11th in a series of biennial reports on the status of women and minorities in science and engineering. The reports are mandated by the Science and Engineering Equal Opportunities Act (Public Law 96-5 16) which was amended in 1998 to include persons with disabilities. The primary purpose of this report is to serve as an…
White, Jeffry L.; Massiha, G. H.
Women make up 47% of the total U.S. workforce, but are less represented in engineering, computer sciences, and the physical sciences. In addition, race and ethnicity are salient factors and minority women comprise fewer than 1 in 10 scientist or engineer. In this paper, a review of the literature is under taken that explores the many challenges…
National Academies Press, 2006
Although more women than men participate in higher education in the United States, the same is not true when it comes to pursuing careers in science and engineering. To Recruit and Advance: Women Students and Faculty in Science and Engineering identifies and discusses better practices for recruitment, retention, and promotion for women scientists…
Neumann, Idell; Abrahams, Norman M.
This project was the result of the Navy's increasing manpower needs for high quality officers with engineering and science training and the desire to have larger numbers of midshipmen elect engineering and science majors at the Naval Academy. In order to accomplish this, a Strong Vocational Interest Blank (SVIB) was created to aid in selecting…
Berland, Leema K.; Steingut, Rebecca
Previous research suggests that in classes that take an integrated approach to science, technology, engineering, and math (STEM) education, students tend to engage in fulfilling goals of their engineering design challenges, but only inconsistently engage with the related math and science content. The present research examines these inconsistencies…
Charlton, Patricia; Avramides, Katerina
This paper focuses on a design based research study about STEM (Science, Technology, Engineering and Maths) learning by making through collaboration and production. This study examines learning by making by students to explore STEM using a constructionist approach with a particular focus on computer science and engineering. The use of IoT as a…
Ing, Marsha; Aschbacher, Pamela R.; Tsai, Sherry M.
This longitudinal study analyzes survey responses in seventh, eighth, and ninth grade from diverse public school students (n = 482) to explore gender differences in engineering and science career preferences. Females were far more likely to express interest in a science career (31%) than an engineering career (13%), while the reverse was true for…
This paper is a case study of first-year science and engineering students' understandings of plagiarism. Students were surveyed for their views on scenarios illustrating instances of plagiarism in the context of the academic work and assessment of science and engineering students. The aim was to explore their understandings of plagiarism and their…
Tucci, Valerie K.
This study, the first phase of a multi-phase effort, was undertaken to assess and provide for the information needs of the Faculty of the Schools of Science and Engineering at The College of New Jersey (TCNJ) in the digital age. The objectives of this phase were to: 1) gain an in-depth understanding of how computer science and engineering faculty…
What factors might be causing the low participation of women Science, Technology, Engineering and Mathematics (STEM) fields? What can be done to attract more girls and women into STEM in Asia and beyond? The report, "A Complex Formula. Girls and Women in Science, Technology, Engineering and Mathematics in Asia", answers three fundamental…
I use the 1993 and 2003 National Surveys of College Graduates to examine the higher exit rate of women compared to men from science and engineering relative to other fields. I find that the higher relative exit rate is driven by engineering rather than science, and show that 60% of the gap can be explained by the relatively greater exit rate from…
Olund, Jeanine K.
Although the number of women entering science, technology, engineering, and mathematics (STEM) disciplines has increased in recent years, overall there are still more men than women completing four-year degrees in these fields, especially in physics, engineering, and computer science. At higher levels of education and within the workplace, the…
As more international doctoral students flow into science and engineering departments in American research universities, a marked shift on the demographic composition of doctoral student bodies has been witnessed. Using a dataset combining a survey of science and engineering department chairs with the latest department evaluation information, this…
Full Text Available The QR factorization is one of the most important operations in dense linear algebra, offering a numerically stable method for solving linear systems of equations including overdetermined and underdetermined systems. Modern implementations of the QR factorization, such as the one in the LAPACK library, suffer from performance limitations due to the use of matrix–vector type operations in the phase of panel factorization. These limitations can be remedied by using the idea of updating of QR factorization, rendering an algorithm, which is much more scalable and much more suitable for implementation on a multi-core processor. It is demonstrated how the potential of the cell broadband engine can be utilized to the fullest by employing the new algorithmic approach and successfully exploiting the capabilities of the chip in terms of single instruction multiple data parallelism, instruction level parallelism and thread-level parallelism.
Barthes, Julien; Özçelik, Hayriye; Hindié, Mathilde; Ndreu-Halili, Albana; Hasan, Anwarul; Vrana, Nihal Engin
In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells' behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional tissue engineering scaffolds spatially and temporally. In this review, we will focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities. The effect of these parameters on the cellular behaviour within tissue engineering context is discussed and how these parameters are used to develop engineered tissues is elaborated. Also, recent techniques developed for the monitoring of the cell microenvironment in vitro and in vivo are reviewed, together with recent tissue engineering applications where the control of cell microenvironment has been exploited. Cell microenvironment engineering and monitoring are crucial parts of tissue engineering efforts and systems which utilize different components of the cell microenvironment simultaneously can provide more functional engineered tissues in the near future.
Crabtree, George [Argonne National Lab. (ANL), Argonne, IL (United States); Glotzer, Sharon [University of Michigan; McCurdy, Bill [University of California Davis; Roberto, Jim [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
abating, has enabled the development of computer simulations and models of unprecedented fidelity. We are at the threshold of a new era where the integrated synthesis, characterization, and modeling of complex materials and chemical processes will transform our ability to understand and design new materials and chemistries with predictive power. In turn, this predictive capability will transform technological innovation by accelerating the development and deployment of new materials and processes in products and manufacturing. Harnessing the potential of computational science and engineering for the discovery and development of materials and chemical processes is essential to maintaining leadership in these foundational fields that underpin energy technologies and industrial competitiveness. Capitalizing on the opportunities presented by simulation-based engineering and science in materials and chemistry will require an integration of experimental capabilities with theoretical and computational modeling; the development of a robust and sustainable infrastructure to support the development and deployment of advanced computational models; and the assembly of a community of scientists and engineers to implement this integration and infrastructure. This community must extend to industry, where incorporating predictive materials science and chemistry into design tools can accelerate the product development cycle and drive economic competitiveness. The confluence of new theories, new materials synthesis capabilities, and new computer platforms has created an unprecedented opportunity to implement a "materials-by-design" paradigm with wide-ranging benefits in technological innovation and scientific discovery. The Workshop on Computational Materials Science and Chemistry for Innovation was convened in Bethesda, Maryland, on July 26-27, 2010. Sponsored by the Department of Energy (DOE) Offices of Advanced Scientific Computing Research and Basic Energy Sciences, the workshop
Ikeguchi, Tohru; Tokuda, Isao
Synchronization is a ubiquitous phenomenon of coupled nonlinear oscillators, commonly found in physics, engineering, biology, and other diverse disciplines. It has a long research history back to Christiaan Huygens, who discovered synchronized motion of two pendulum clocks in 1673. It is very easy to observe synchronization in our daily life: e.g., metronomes, candle fires, pet-bottle oscillators, saltwater oscillators, and so on(See, for example, experimental movies at http://www.youtube.com/user/IkeguchiLab?feature=watch). For the last few decades, significant development has been made from both theories and experiments on synchronization of coupled limit cycle oscillators as well as coupled chaotic oscillators. Applications have been also developed to communication technologies, controlling techniques, and data analysis. Combined with the idea from complex network theory, neuroscience, and systems biology, the research speed of synchronization has been even accelerated. This Special Section of NOLTA is primarily dedicated to the recent advanced development of basics and applications of synchronization in science and engineering. A number of qualified works is included, ranging from experimental study on synchronization of Huygens' system, analog circuits, and singing voice to applied study of synchronization in communication networks. One invited paper is devoted to comprehensive reviews on generalized synchronization of chaotic oscillators. On behalf of the editorial committee of the special section, the guest editors would like to express their sincere thanks to all the authors for their excellent contributions. In particular, they are grateful to Prof. Dr. Ulrich Parlitz for contributing his distinguished review article. They would also like to thank the reviewers and the members of the guest editorial committee, especially Prof. Hiroo Sekiya of Chiba University and the editorial staffs of the NOLTA journal, for their supports on publishing this Special
Applications Center ASC academic specialty code BA/BS bachelor of science/bachelor of art CAD critical accession degree CE civil engineering CFM career...0XXX Inter-area specialization 1XXX Administration management, military science 2XXX Arts , humanities, and education 3XXX Biological and...Services 12XXXX Personal and Culinary Services 13XXXX Education 14XXXX Engineering 15XXXX Engineering Technologies/Technicians 16XXXX Foreign
Full Text Available In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional tissue engineering scaffolds spatially and temporally. In this review, we will focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities. The effect of these parameters on the cellular behaviour within tissue engineering context is discussed and how these parameters are used to develop engineered tissues is elaborated. Also, recent techniques developed for the monitoring of the cell microenvironment in vitro and in vivo are reviewed, together with recent tissue engineering applications where the control of cell microenvironment has been exploited. Cell microenvironment engineering and monitoring are crucial parts of tissue engineering efforts and systems which utilize different components of the cell microenvironment simultaneously can provide more functional engineered tissues in the near future.
Shao, Jiawei; Xue, Shuai; Yu, Guiling; Yu, Yuanhuan; Yang, Xueping; Bai, Yu; Zhu, Sucheng; Yang, Linfeng; Yin, Jianli; Wang, Yidan; Liao, Shuyong; Guo, Sanwei; Xie, Mingqi; Fussenegger, Martin; Ye, Haifeng
With the increasingly dominant role of smartphones in our lives, mobile health care systems integrating advanced point-of-care technologies to manage chronic diseases are gaining attention. Using a multidisciplinary design principle coupling electrical engineering, software development, and synthetic biology, we have engineered a technological infrastructure enabling the smartphone-assisted semiautomatic treatment of diabetes in mice. A custom-designed home server SmartController was programmed to process wireless signals, enabling a smartphone to regulate hormone production by optically engineered cells implanted in diabetic mice via a far-red light (FRL)-responsive optogenetic interface. To develop this wireless controller network, we designed and implanted hydrogel capsules carrying both engineered cells and wirelessly powered FRL LEDs (light-emitting diodes). In vivo production of a short variant of human glucagon-like peptide 1 (shGLP-1) or mouse insulin by the engineered cells in the hydrogel could be remotely controlled by smartphone programs or a custom-engineered Bluetooth-active glucometer in a semiautomatic, glucose-dependent manner. By combining electronic device-generated digital signals with optogenetically engineered cells, this study provides a step toward translating cell-based therapies into the clinic. Copyright © 2017, American Association for the Advancement of Science.
Roggenthen, W.; Wang, J.
The Homestake Mine in South Dakota ceased gold production in 2002 and was sealed for entry in 2003. The announcement of mine closure triggered the revival of a national initiative to establish a deep underground facility, currently known as the Deep Underground Science and Engineering Laboratory (DUSEL). The National Science Foundation announced that solicitations were to be issued in 2004 and 2005, with the first one (known as S-1) issued in June, 2004. The focus of S-1 is on site non-specific technical requirements to define the scientific program at DUSEL. Earth scientists and physicists participated in an S-1 workshop at Berkeley in August, 2004. This abstract presents the prospects of the Homestake Mine to accommodate the earth science scientific programs defined at the S-1 workshop. The Homestake Mine has hundreds of kilometers of drifts over fifty levels accessible (upon mine reopening) for water evaluation, seepage quantification, seismic monitoring, geophysical imaging, geological mapping, mineral sampling, ecology and geo-microbiology. The extensive network of drifts, ramps, and vertical shafts allows installation of 10-kilometer-scale seismograph and electromagnetic networks. Ramps connecting different levels, typically separated by 150 ft, could be instrumented for flow and transport studies, prior to implementation of coupled thermal-hydro-chemical-mechanical-biological processes testing. Numerous large rooms are available for ecological and introduced-material evaluations. Ideas for installing instruments in cubic kilometers of rock mass can be realized over multiple levels. Environmental assessment, petroleum recovery, carbon sequestration were among the applications discussed in the S-1 workshop. If the Homestake Mine can be expediently reopened, earth scientists are ready to perform important tests with a phased approach. The drifts and ramps directly below the large open pit could be the first area for shallow testing. The 4,850 ft level is the
Ferreira, Maria M.
This study examined the impact of an after-school science program that incorporated cooperative learning, hands-on activities, mentoring, and role models on a group of minority female students' attitudes toward science, engineering, and mathematics. Eighteen African American middle school students participated in the study. Seven female engineers…
National Science Foundation, Washington, DC. Div. of Science Resources Studies.
Doctorate holders who received their degrees in science or other fields between 1930 and 1972 and who held jobs in the sciences and engineering (S/E) were surveyed. Findings include the following: employment of doctorates in S/E activities continued to grow between 1979 and 1981 at the same rate since 1975, about 5 percent per year, reaching a…
Chao, Jie; Xie, Charles; Nourian, Saeid; Chen, Guanhua; Bailey, Siobhan; Goldstein, Molly H.; Purzer, Senay; Adams, Robin S.; Tutwiler, M. Shane
Many pedagogical innovations aim to integrate engineering design and science learning. However, students frequently show little attempt or have difficulties in connecting their design projects with the underlying science. Drawing upon the Cultural-Historical Activity Theory, we argue that the design tools available in a learning environment…
Schmidt, Shelly J.; Bohn, Dawn M.; Rasmussen, Aaron J.; Sutherland, Elizabeth A.
The overarching goal of the Science, Technology, Engineering, and Mathematics (STEM) Education Initiative is to foster effective STEM teaching and learning throughout the educational system at the local, state, and national levels, thereby producing science literate citizens and a capable STEM workforce. To contribute to achieving this goal, we…
Many people hold this truth to be self-evident that universities should enroll more female students in science and engineering; the main question then being how. Typical arguments include possible benefits to women, possible benefits to the economy, and the unfairness of the current female under-representation. However, when clearly stated and scrutinized these arguments in fact lead to the conclusion that there should be more women in scientific disciplines in higher education in the sense that we should expect more women (which various kinds of discrimination may prevent), not that we should actively enroll more women. Outreach programs towards high school students may therefore be logically incompatible with the arguments supposed to justify them. They should purport to allow women to graduate in a field congruent with her abilities and desires, rather than try to draw as many of them to scientific disciplines as possible: one cannot try to 'recruit' as many female students as possible while claiming to help them choose more freely.
Anthony S. Clare
Full Text Available The oceans cover approximately 71% of the Earth’s surface and contain more than 97% of the planet’s water, representing over 100 times more liveable volume than the terrestrial habitat. Approximately fifty percent of the species on the planet occupy this ocean biome, much of which remains unexplored. The health and sustainability of the oceans are threatened by a combination of pressures associated with climate change and the ever-increasing demands we place on them for food, recreation, trade, energy and minerals. The biggest threat, however, is the pace of change to the oceans, e.g., ocean acidification, which is unprecedented in human history. Consequently, there has never been a greater need for the rapid and widespread dissemination of the outcomes of research aimed at improving our understanding of how the oceans work and solutions to their sustainable use. It is our hope that this new online, open-access Journal of Marine Science and Engineering will go some way to fulfilling this need. [...
Renk, Karl F
Basics of Laser Physics provides an introductory presentation of the field of all types of lasers. It contains a general description of the laser, a theoretical treatment and a characterization of its operation as it deals with gas, solid state, free-electron and semiconductor lasers and, furthermore, with a few laser related topics. The different subjects are connected to each other by the central principle of the laser, namely, that it is a self-oscillating system. Special emphasis is put on a uniform treatment of gas and solid-state lasers, on the one hand, and semiconductor lasers, on the other hand. The discussions and the treatment of equations are presented in a way that a reader can immediately follow. The book addresses undergraduate and graduate students of science and engineering. Not only should it enable instructors to prepare their lectures, but it can be helpful to students for preparing for an examination.
Carlton, Matthew A
This updated and revised first-course textbook in applied probability provides a contemporary and lively post-calculus introduction to the subject of probability. The exposition reflects a desirable balance between fundamental theory and many applications involving a broad range of real problem scenarios. It is intended to appeal to a wide audience, including mathematics and statistics majors, prospective engineers and scientists, and those business and social science majors interested in the quantitative aspects of their disciplines. The textbook contains enough material for a year-long course, though many instructors will use it for a single term (one semester or one quarter). As such, three course syllabi with expanded course outlines are now available for download on the book’s page on the Springer website. A one-term course would cover material in the core chapters (1-4), supplemented by selections from one or more of the remaining chapters on statistical inference (Ch. 5), Markov chains (Ch. 6), stoch...
The goal of this book is to present a unified mathematical treatment of diverse problems in mathematics, physics, computer science, and engineer ing using geometric algebra. Geometric algebra was invented by William Kingdon Clifford in 1878 as a unification and generalization of the works of Grassmann and Hamilton, which came more than a quarter of a century before. Whereas the algebras of Clifford and Grassmann are well known in advanced mathematics and physics, they have never made an impact in elementary textbooks where the vector algebra of Gibbs-Heaviside still predominates. The approach to Clifford algebra adopted in most of the ar ticles here was pioneered in the 1960s by David Hestenes. Later, together with Garret Sobczyk, he developed it into a unified language for math ematics and physics. Sobczyk first learned about the power of geometric algebra in classes in electrodynamics and relativity taught by Hestenes at Arizona State University from 1966 to 1967. He still vividly remembers a feeling ...
McDonald, Harry E.
The United States ranking among the world in science, technology, engineering, and mathematics (STEM) education is decreasing. To counteract this problem NASA has made it part of its mission to promote STEM education among the nation s youth. Mockups can serve as a great tool when promoting STEM education in America. The Orion Cockpit Working Group has created a new program called Students Shaping America s Next Space Craft (SSANS) to outfit the Medium Fidelity Orion Mockup. SSANS will challenge the students to come up with unique designs to represent the flight design hardware. There are two main types of project packages created by SSANS, those for high school students and those for university students. The high school projects will challenge wood shop, metal shop and pre-engineering classes. The university projects are created mainly for senior design projects and will require the students to perform finite element analysis. These projects will also challenge the undergraduate students in material selection and safety requirements. The SSANS program will help NASA in its mission to promote STEM education, and will help to shape our nations youth into the next generation of STEM leaders.
Fairhurst, C.; Onstott, T. C.; Tiedje, J. M.; McPherson, B.; Pfiffner, S. M.; Wang, J. S.
A summary of efforts to create one or more Deep Underground Science and Engineering Laboratories (DUSEL) in the United States is presented. A workshop in Berkeley, August 11-14, 2004, explored the technical requirements of DUSEL for research in basic and applied geological and microbiological sciences, together with elementary particle physics and integrated education and public outreach. The workshop was organized by Bernard Sadoulet, an astrophysicist and the principal investigator (PI) of a community-wide DUSEL program evolving in coordination with the National Science Foundation. The PI team has three physicists (in nuclear science, high-energy physics, and astrophysics) and three earth scientists (in geoscience, biology and engineering). Presentations, working group reports, links to previous workshop/meeting talks, and information about DUSEL candidate sites, are presented in http://neutrino.lbl.gov/DUSELS-1. The Berkeley workshop is a continuation of decades of efforts, the most recent including the 2001 Underground Science Conference's earth science and geomicrobiology workshops, the 2002 International Workshop on Neutrino and Subterranean Science, and the 2003 EarthLab Report. This perspective (from three earth science co-PIs, the lead author of EarthLab report, the lead scientist of education/outreach, and the local earth science organizer) is to inform the community on the status of this national initiative, and to invite their active support. Having a dedicated facility with decades-long, extensive three-dimensional underground access was recognized as the most important single attribute of DUSEL. Many research initiatives were identified and more are expected as the broader community becomes aware of DUSEL. Working groups were organized to evaluate hydrology and coupled processes; geochemistry; rock mechanics/seismology; applications (e.g., homeland security, environment assessment, petroleum recovery, and carbon sequestration); geomicrobiology and
... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Advisory Committee for Computer and Information Science and Engineering; Cancellation of Meeting SUMMARY: As a result of the impact of the recent government shutdown, the National Science Foundation is...
Gándara, Fernanda; Silva, Monica
This study seeks to develop a better understanding of the underrepresentation of women in science and engineering by analyzing the gender gaps (a) in the interest in pursuing a science degree and (b) on science achievement. We use national-level college admissions data to examine gender differences and to explore the association between these…
Septiani, A.; Rustaman, N. Y.
A descriptive study about the implementation of performance assessment in STEM based instruction was carried out to investigate the tenth grade of Vocational school students’ science process skills during the teaching learning processes. A number of tenth grade agriculture students was involved as research subjects selected through cluster random sampling technique (n=35). Performance assessment was planned on skills during the teaching learning process through observation and on product resulted from their engineering practice design. The procedure conducted in this study included thinking phase (identifying problem and sharing idea), designing phase, construction phase, and evaluation phase. Data was collected through the use of science process skills (SPS) test, observation sheet on student activity, as well as tasks and rubrics for performance assessment during the instruction. Research findings show that the implementation of performance assessment in STEM education in planting media could detect students science process skills better from the observation individually compared through SPS test. It was also found that the result of performance assessment was diverse when it was correlated to each indicator of SPS (strong and positive; weak and positive).
Mercado, Janet; Sengupta-Irving, Tesha
.... Recent science education reforms integrate science and engineering throughout K12 education, making it imperative to explore the conceptions teachers hold of engineering as a discipline, and as an approach to teaching...
Qi, Bin; Guo, Linli; Zhang, Zhixian
Space life science and life support engineering are prominent problems in manned deep space exploration mission. Some typical problems are discussed in this paper, including long-term life support problem, physiological effect and defense of varying extraterrestrial environment. The causes of these problems are developed for these problems. To solve these problems, research on space life science and space medical-engineering should be conducted. In the aspect of space life science, the study of space gravity biology should focus on character of physiological effect in long term zero gravity, co-regulation of physiological systems, impact on stem cells in space, etc. The study of space radiation biology should focus on target effect and non-target effect of radiation, carcinogenicity of radiation, spread of radiation damage in life system, etc. The study of basic biology of space life support system should focus on theoretical basis and simulating mode of constructing the life support system, filtration and combination of species, regulation and optimization method of life support system, etc. In the aspect of space medical-engineering, the study of bio-regenerative life support technology should focus on plants cultivation technology, animal-protein production technology, waste treatment technology, etc. The study of varying gravity defense technology should focus on biological and medical measures to defend varying gravity effect, generation and evaluation of artificial gravity, etc. The study of extraterrestrial environment defense technology should focus on risk evaluation of radiation, monitoring and defending of radiation, compound prevention and removal technology of dust, etc. At last, a case of manned lunar base is analyzed, in which the effective schemes of life support system, defense of varying gravity, defense of extraterrestrial environment are advanced respectively. The points in this paper can be used as references for intensive study on key
Kroposki, Benjamin [National Renewable Energy Lab. (NREL), Golden, CO (United States)
This report highlights journal articles published in 2016 by researchers in the Power Systems Engineering Center. NREL's Power Systems Engineering Center published 47 journal and magazine articles in the past year, highlighting recent research in grid modernization.
... standards, product safety tests and test methods, performance criteria, design specifications, and quality control standards for consumer products, based on engineering and scientific methods. It conducts... and Commission staff as requested; and provides engineering technical support to other Commission...
Liu, Zun Chang; Chang, Thomas Ming Swi
Adult stem cells, especially isolated from bone marrow, have been extensively investigated in recent years. Studies focus on their multiple plasticity oftransdifferentiating into various cell lineages and on their potential in cellular therapy in regenerative medicine. In many cases, there is the need for tissue engineering manipulation. Among the different approaches of stem cells tissue engineering, microencapsulation can immobilize stem cells to provide a favorable microenvironment for stem cells survival and functioning. Furthermore, microencapsulated stem cells are immunoisolated after transplantation. We show that one intraperitoneal injection of microencapsulated bone marrow stem cells can prolong the survival of liver failure rat models with 90% of the liver removed surgically. In addition to transdifferentiation, bone marrow stem cells can act as feeder cells. For example, when coencapsulated with hepatocytes, stem cells can increase the viability and function of the hepatocytes in vitro and in vivo.
Liu, Zun Chang; Chang, Thomas Ming Swi
Adult stem cells, especially isolated from bone marrow, have been extensively investigated in recent years. Studies focus on their multiple plasticity of transdifferentiating into various cell lineages and on their potential in cellular therapy in regenerative medicine. In many cases, there is the need for tissue engineering manipulation. Among the different approaches of stem cells tissue engineering, microencapsulation can immobilize stem cells to provide a favorable microenvironment for stem cells survival and functioning. Furthermore, microencapsulated stem cells are immunoisolated after transplantation. We show that one intraperitoneal injection of microencapsulated bone marrow stem cells can prolong the survival of liver failure rat models with 90% of the liver removed surgically. In addition to transdifferentiation, bone marrow stem cells can act as feeder cells. For example, when coencapsulated with hepatocytes, stem cells can increase the viability and function of the hepatocytes in vitro and in vivo. PMID:20384219
Full Text Available Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replace injured ones in patients. Therefore, cell-based strategies for meniscus tissue engineering play a fundamental role in meniscal regeneration. According to current studies, the main cell-based strategies for meniscus tissue engineering are single cell type strategies; cell coculture strategies also were applied to meniscus tissue engineering. Likewise, on the one side, the zonal recapitulation strategies based on mimicking meniscal differing cells and internal architectures have received wide attentions. On the other side, cell self-assembling strategies without any scaffolds may be a better way to build a bionic meniscus. In this review, we primarily discuss cell seeds for meniscus tissue engineering and their application strategies. We also discuss recent advances and achievements in meniscus repair experiments that further improve our understanding of meniscus tissue engineering.
Selcen Guzey, S.; Harwell, Michael; Moreno, Mario; Peralta, Yadira; Moore, Tamara J.
The new science education reform documents call for integration of engineering into K-12 science classes. Engineering design and practices are new to most science teachers, meaning that implementing effective engineering instruction is likely to be challenging. This quasi-experimental study explored the influence of teacher-developed, engineering…
Includes papers in the following fields: Aerospace Engineering, Agricultural Engineering, Chemical Engineering, Civil Engineering, Electrical Engineering, Environmental Engineering, Industrial Engineering, Materials Engineering, Mechanical...
The International Conference on Bio-Medical Instrumentation and related Engineering and Physical Sciences (BIOMEP 2015) took place in the Technological Educational Institute (TEI) of Athens, Greece on June 18-20, 2015 and was organized by the Department of Biomedical Engineering. The scope of the conference was to provide a forum on the latest developments in Biomedical Instrumentation and related principles of Physical and Engineering sciences. Scientists and engineers from academic, industrial and health disciplines were invited to participate in the Conference and to contribute both in the promotion and dissemination of the scientific knowledge.
The New York Hall of Science, in response to the national crisis in education and employment in science and engineering, is developing and pilot testing a unique, interactive, video-based, hypermedia series on energy-related and other science and engineering careers for middle and junior high school students. Working in collaboration with the Consortium for Mathematics and its Applications (COMAP) and the Educational Film Center (EFC), this pilot-demonstration phase will last 14 months, during which time the basic design, production, and testing of eight science and engineering career modules (video and software) will be completed and installed as an interactive educational exhibit at the New York Hall of Science. This career education package will then be distributed to other science technology centers nationwide.
Freeman, Scott; Eddy, Sarah L; McDonough, Miles; Smith, Michelle K; Okoroafor, Nnadozie; Jordt, Hannah; Wenderoth, Mary Pat
To test the hypothesis that lecturing maximizes learning and course performance, we metaanalyzed 225 studies that reported data on examination scores or failure rates when comparing student performance in undergraduate science, technology, engineering, and mathematics (STEM) courses under traditional lecturing versus active learning. The effect sizes indicate that on average, student performance on examinations and concept inventories increased by 0.47 SDs under active learning (n = 158 studies), and that the odds ratio for failing was 1.95 under traditional lecturing (n = 67 studies). These results indicate that average examination scores improved by about 6% in active learning sections, and that students in classes with traditional lecturing were 1.5 times more likely to fail than were students in classes with active learning. Heterogeneity analyses indicated that both results hold across the STEM disciplines, that active learning increases scores on concept inventories more than on course examinations, and that active learning appears effective across all class sizes--although the greatest effects are in small (n ≤ 50) classes. Trim and fill analyses and fail-safe n calculations suggest that the results are not due to publication bias. The results also appear robust to variation in the methodological rigor of the included studies, based on the quality of controls over student quality and instructor identity. This is the largest and most comprehensive metaanalysis of undergraduate STEM education published to date. The results raise questions about the continued use of traditional lecturing as a control in research studies, and support active learning as the preferred, empirically validated teaching practice in regular classrooms.
Jones, Keith Wayne
The purpose of this study was to determine if there is adequate documentation of an historical role of African and African American involvement in science, engineering, and technology. Through the use of history of science and technology research methodology, along with an examination of the sociological and economic impacts of adequately accredited innovations and inventions contributed by Africans and African Americans, the researcher investigated their contributions to the following areas of science and technology: life science, physical sciences and chemistry, engineering, and science education. In regard to the timeframe for this study, the researcher specifically investigated African and African American involvement in science and technology that includes periods prior to black enslavement, scientific racism and colonialism, as well as during and after those periods. This research study reveals that there are adequate historical data regarding African and African American contributions to science, engineering, and technology. The data reveals that for many millennia African peoples have been continually involved in science and world science histories. The data further show that the numbers of African Americans acquiring BS, MS, Ph.D., Doctor of Science and Doctor of Engineering degrees in science and engineering disciplines are increasing. That these increases are not happening at a rate representative of the present or future African American percentages of the population. Consequently, because of future changes in our nation's demographics, increasing the numbers of people from under-represented groups who pursue scientific and engineering professions has become a matter of national security at the highest levels of government. Moreover, African Americans, Hispanics, and Native Americans are not pursuing careers or taking courses in science and engineering at a rate high enough to fulfill the prospective needs for the United States' industries, government
The Committee on Women in Science and Engineering (CWSE), a continuing committee established within the National Research Council (NRC) in January 1991, has a four-pronged mandate to: (1) collect and disseminate current data about the participation of women in science and engineering to broad constituencies in academe, government, industry, and professional societies; (2) monitor the progress of efforts to increase the participation of women in scientific and engineering careers; (3) conduct symposia, workshops, and other meetings of experts to explore the policy environment, to stimulate and encourage initiatives in program development for women in science and engineering, and to evaluate their effectiveness on a regular basis; and (4) propose research and conduct special studies on issues particularly relevant to women scientists and engineers in order to develop reports that will document evidence and articulate NRC recommendations for action. CWSE activities will focus on the participation of women in science and engineering at the postsecondary level of education and in various employment sectors. This report is the culmination of an initial examination by CWSE of the status of women scientists and engineers in the United States. In addition to providing statistics on the participation of women in the education/employment pipeline, it summarizes the Committee's deliberations relating to its role in increasing the participation and improving the status of women in science and engineering.
The following master's thesis is composed of two manuscripts describing STEM teachers' orientations to science teaching through engineering within the context of the Science Learning through Engineering Design (SLED) partnership. The framework guiding both studies was science teaching orientations, a component of pedagogical content knowledge. Data were collected via semi-structured interviews, multi-day classroom observations, pre- and post-observation interviews, implementation plans, and written reflections. Data sources were analyzed to generate two orientations to science teaching through engineering design for each participant. The first manuscript illustrates a single case study conducted with a sixth grade STEM teacher. Results of this study revealed a detailed picture of the teacher's goals, practices, assessments, and general views when teaching science through engineering design. Common themes across the teacher's instruction were used to characterize her orientations to science teaching through engineering design. Overall, the teacher's orientations showed a shift in her practice from didactic to student-centered methods of teaching as a result of integrating engineering design-based curriculum. The second manuscript describes a comparative case study of two sixth grade SLED participants. Results of this study revealed more complex and diverse relationships between the teachers' orientations to teaching science through engineering design and their instruction. Participants' orientations served as filters for instruction, guided by their divergent purposes for science teaching. Furthermore, their orientations and resulting implementation were developed from knowledge gained in teacher education, implying that teacher educators and researchers can use this framework to learn more about how teachers' knowledge is used to integrate engineering and science practices in the K-12 classroom.
de Jong, Anthonius J.M.; Linn, Marcia C.; Zacharia, Zacharias C.
The world needs young people who are skillful in and enthusiastic about science and who view science as their future career field. Ensuring that we will have such young people requires initiatives that engage students in interesting and motivating science experiences. Today, students can investigate
Mulvey, Kelly Lynn; Miller, Bridget; Rizzardi, Victoria
To investigate gender stereotypes, demonstrated engineering aptitude, and attitudes, children (N=105) solved an engineering problem using either pastel-colored or primary-colored materials. Participants also evaluated the acceptability of denial of access to engineering materials based on gender and counter-stereotypic preferences (i.e., a boy who prefers pastel-colored materials). Whereas material color was not related to differences in female participants' performance, younger boys assigned to pastel materials demonstrated lower engineering aptitude than did other participants. In addition, results documented age- and gender-related differences; younger participants, and sometimes boys, exhibited less flexibility regarding gender stereotypes than did older and female participants. The findings suggest that attempts to enhance STEM (science, technology, engineering, and math) engagement or performance through the color of STEM materials may have unintended consequences. Copyright © 2017 Elsevier Inc. All rights reserved.
Zygielbaum, Arthur I.
An external review of the Integrated Technology Plan for the Civil Space Program is presented. This review is specifically concerned with the Software Engineering Program. The goals of the Software Engineering Program are as follows: (1) improve NASA's ability to manage development, operation, and maintenance of complex software systems; (2) decrease NASA's cost and risk in engineering complex software systems; and (3) provide technology to assure safety and reliability of software in mission critical applications.
The principal aim of this thesis was to advance the development of tissue engineered posterolateral spinal fusion by investigating the potential of calcium phosphate ceramic materials to support cell based tissue engineered bone formation. This was accomplished by developing several novel model
Spelt, Elsbeth; Luning, Pieternelleke Arianne; Boekel, van Tiny; Mulder, Martin
Preparing science and engineering students to work in interdisciplinary teams necessitates research on teaching and learning of interdisciplinary thinking. A multidimensional approach was taken to examine student interdisciplinary learning in a master course on food quality management. The
Matthews, Christine M
The increased presence of foreign students in graduate science and engineering programs and in the scientific workforce has been and continues to be of concern to some in the scientific community. Enrollment of U.S...
Spelt, Elsbeth; Luning, Pieternelleke Arianne; Boekel, van Tiny; Mulder, Martin
Preparing science and engineering students to work in interdisciplinary teams necessitates research on teaching and learning of interdisciplinary thinking. A multidimensional approach was taken to examine student interdisciplinary learning in a master course on food quality management. The
Committee on Maximizing the Potential of Women in Academic Science and Engineering; National Academy of Sciences; National Academy of Engineering
.... Women make up an increasing proportion of science and engineering majors at all institutions, including top programs such as those at the Massachusetts Institute of Technology where women make up 51...
Networking and Information Technology Research and Development, Executive Office of the President — This report details the challenges and opportunities discussed at the NITRD sponsored multi-agency workshop on Computational Science and Engineering Software...
Reviews the commitment of the National Science Foundation (NSF) to employing minority women scientists and engineers and the progress made in the decades since the equal opportunity plan was established in 1969. (WRM)
Kuenzi, Jeffrey J; Matthews, Christine M; Mangan, Bonnie F
There is growing concern that the United States is not preparing a sufficient number of students, teachers, and practitioners in the areas of science, technology, engineering, and mathematics (STEM...
The year 1996-97 represented our fifteenth successful DoD Science and Engineering Apprenticeship Program for High School Students at Florida State University, sponsored by the Office of Naval Research...
de Jong, Ton; Linn, Marcia C; Zacharia, Zacharias C
The world needs young people who are skillful in and enthusiastic about science and who view science as their future career field. Ensuring that we will have such young people requires initiatives that engage students in interesting and motivating science experiences. Today, students can investigate scientific phenomena using the tools, data collection techniques, models, and theories of science in physical laboratories that support interactions with the material world or in virtual laboratories that take advantage of simulations. Here, we review a selection of the literature to contrast the value of physical and virtual investigations and to offer recommendations for combining the two to strengthen science learning.
We are in the problematic world created by the modern science and technology. The general public are increasingly concerned about the risks rather than the benefits of technologies. Nevertheless, to cast a critical eye upon technological endeavor of industries is not popular in the engineering field. Engineering education tends to only emphasize the bright side of science and technology and does not necessarily aim to educate engineers who want be responsible for the real needs of the society. This paper first reviews the problems of present engineering education from the viewpoint of fundamental concepts of engineers developed by Henry Dyer who initiated Japan's engineering education in the Meiji era. Then expectations of the society for modern engineers are noticed. Lastly, experiences of an experimental new class which encourages engineering students to look on the dark side of science and technology and to think of a new role of engineers in the technological world are summarized. Results show that engineering students are greatly interested in the new role.
Zhou, Chunfang; Valero, Paola
Different pedagogical strategies influence the development of creativity in project groups in science and engineering education. This study is a comparison between two cases: Problem-Based Learning (PBL) in Denmark and Project-Organized Learning (POL) in China.......Different pedagogical strategies influence the development of creativity in project groups in science and engineering education. This study is a comparison between two cases: Problem-Based Learning (PBL) in Denmark and Project-Organized Learning (POL) in China....
Field, Richard V., Jr.
Mathematical models are developed and used to study the properties of complex systems and/or modify these systems to satisfy some performance requirements in just about every area of applied science and engineering. A particular reason for developing a model, e.g., performance assessment or design, is referred to as the model use. Our objective is the development of a methodology for selecting a model that is sufficiently accurate for an intended use. Information on the system being modeled is, in general, incomplete, so that there may be two or more models consistent with the available information. The collection of these models is called the class of candidate models. Methods are developed for selecting the optimal member from a class of candidate models for the system. The optimal model depends on the available information, the selected class of candidate models, and the model use. Classical methods for model selection, including the method of maximum likelihood and Bayesian methods, as well as a method employing a decision-theoretic approach, are formulated to select the optimal model for numerous applications. There is no requirement that the candidate models be random. Classical methods for model selection ignore model use and require data to be available. Examples are used to show that these methods can be unreliable when data is limited. The decision-theoretic approach to model selection does not have these limitations, and model use is included through an appropriate utility function. This is especially important when modeling high risk systems, where the consequences of using an inappropriate model for the system can be disastrous. The decision-theoretic method for model selection is developed and applied for a series of complex and diverse applications. These include the selection of the: (1) optimal order of the polynomial chaos approximation for non-Gaussian random variables and stationary stochastic processes, (2) optimal pressure load model to be
Koch, Amanda Joy
A national shortage of workers in Science, Technology, Engineering, and Math (STEM) occupations has led to efforts to identify why people leave these fields. Lower persistence rates in STEM for females than for males have also led to examinations of features that cause females to leave STEM fields. The current study examines individual- and school-level features that influence undergraduate students' decisions to leave STEM majors, focusing on potential explanations for why females are more likely than males to leave. Persistence in STEM was examined in three samples: (a) persistence through the second year of college in a sample of high school seniors interested in STEM majors; (b) persistence through the fourth year of college in a sample of second year undergraduate STEM majors; and (c) persistence through the second, third, and fourth years of college in a sample of high school seniors interested in STEM majors. Differences between persistence in male-dominated and non-male-dominated STEM majors were also examined. In all samples, gender differences were found for most individual-level predictors, with males tending to score higher than females on measures such as SAT-Math, self-rated STEM ability, and high school extracurricular activities and awards in STEM. On the other hand, females earned better high school grades and had stronger relative non-STEM ability and achievement than males. Bivariate analyses indicated that those who persisted in STEM majors typically had higher scores than those who did not persist for SAT-Math, high school achievement, STEM course taking, undergraduate STEM grades, self-rated STEM ability, interest in STEM, extracurricular activities and awards in STEM, degree goals, and socioeconomic status. Multivariate analyses identified SAT-Math as one of the best predictors of persistence in high school samples, and undergraduate STEM GPA was one of the best predictors in the samples of second year undergraduates. In several samples, a
Duke, Steve R.; Davis, Virginia A.
In the Samuel Ginn College of Engineering at Auburn University, we have integrated a semester long design project based on a toy fuel cell car into our freshman "Introduction to Chemical Engineering Class." The project provides the students a basic foundation in chemical reactions, energy, and dimensional analysis that facilitates…
Cannell, Nori; Zavaleta, Dan
At Desert Vista High School, near Phoenix, Arizona, Perkins Innovation Grant funding is being used to fund a program that is helping to prepare students for careers in engineering by giving them hands-on experience in areas like hydrogen generation and fuel cell utilization. As one enters Dan Zavaleta's automotive and engineering classroom and lab…
Silver, Anne; Rushton, Brian S.
The attitudes of Year 5 primary-school children towards science, engineering and technology (SET) were examined prior to studying the effects of the Horsham Greenpower Goblin Challenge (HGGC), a hands-on SET project. The data collection centred on pupil, parent and teacher questionnaires using Likert scales and picture/word images of scientists…
This highly multidisciplinary volume contains contributions from leading researchers in STEAM-H disciplines (Science, Technology, Engineering, Agriculture, Mathematics and Health). The volume explores new frontiers in multidisciplinary research, including: the mathematics of cardiac arrhythmia; brain research on working memory; penalized ordinal regression to classify melanoma skin samples; forecasting of time series data; dynamics of niche models; analysis of chemical moieties as anticancer agents; study of gene locus control regions; qualitative mathematical modelling; convex quadrics and group circle systems; remanufacturing planning and control; complexity reduction of functional differential equations; computation of viscous interfacial motion; and differentiation in human pluripotent stem cells. An extension of a seminar series at Virginia State University, the collection is intended to foster student interest and participation in interdisciplinary research, and to stimulate new research. The content wi...
Devendra Amatya; Wayne Skaggs; Carl Trettin
For more than a century, agricultural and biological engineers have provided major advances in science, engineering, and technology to increase food and fiber production to meet the demands of a rapidly growing global population. The land base for these technological advances has originated largely from forested lands, which have experienced dramatic declines over the...
This study connects to gender issues within the field of science and technology. Women who had started strongly male-dominated engineering educations at Karlstad University were interviewed to find out why they had chosen these programs. A very clear picture emerged about the professions of the women's fathers. Almost all fathers were engineers or…
Rosser, Sue V., Ed.
This book presents pioneering work in teaching by scientists, mathematicians, and engineers to attract and retain women in these areas. The physical sciences, mathematics, and engineering persist as the professional areas where women have not yet broken the gender barrier. A severe shortage of scientists beginning in the mid-1990s is predicted and…
Hossain, Md. Mokter; G. Robinson, Michael
STEM (science, technology, engineering and mathematics) has been a powerful engine of prosperity in the US since World War II. Currently, American students' performances and enthusiasm in STEM education are inadequate for the US to maintain its leadership in STEM professions unless the government takes more actions to motivate a new generation of…
Snead, Malcolm L; Slavkin, Harold C
The biological, chemical, behavioral and physical sciences provide the fuel for innovation, discovery and technology that continuously improves the quality of the human condition. Computer power derived from the dramatic breakthroughs of the digital revolution has made extraordinary computational capacity available for diagnostic imaging, bioinformatics (the science of information) and numerous aspects of how we practice dentistry in the 21st century. The biological revolution was initiated by the identification of the structure for DNA in 1953, a discovery that continues to catalyze improvements in patient care through new and better diagnostics, treatments and biomaterials. Humanity's most basic and recognizable characteristics--including the face--are now better understood through the elucidation of our genome and proteome, the genes and proteins they encode. Health care providers are beginning to use personalized medicine that is based on a person's genetic makeup and predispositions to disease development. Advances in the fields of genetics, developmental and stem cell biology, and many other disciplines continue to fuel innovative research findings that form the basis for new diagnostic tests, therapeutic interventions and procedures that improve the quality of life for patients. Scientists are on the threshold of applying knowledge in stem cell biology to regenerative medicine and dentistry, heralding an era when clinicians can consider using biological engineering to replace tissues and organs lost to disease or trauma.
DeChenne, Sue Ellen; Koziol, Natalie; Needham, Mark; Enochs, Larry
Graduate teaching assistants (GTAs) in science, technology, engineering, and mathematics (STEM) have a large impact on undergraduate instruction but are often poorly prepared to teach. Teaching self-efficacy, an instructor's belief in his or her ability to teach specific student populations a specific subject, is an important predictor of teaching skill and student achievement. A model of sources of teaching self-efficacy is developed from the GTA literature. This model indicates that teaching experience, departmental teaching climate (including peer and supervisor relationships), and GTA professional development (PD) can act as sources of teaching self-efficacy. The model is pilot tested with 128 GTAs from nine different STEM departments at a midsized research university. Structural equation modeling reveals that K-12 teaching experience, hours and perceived quality of GTA PD, and perception of the departmental facilitating environment are significant factors that explain 32% of the variance in the teaching self-efficacy of STEM GTAs. This model highlights the important contributions of the departmental environment and GTA PD in the development of teaching self-efficacy for STEM GTAs. © 2015 S. E. DeChenne et al. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
Thaysa Fedalto Lopes; Agnes Levandowski; Sabrina Cunha da Fonseca; João Cesar Zielak; Moira Pedroso Leão
...: The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. Literature review...
Galler, Kerstin M; Widbiller, Matthias
Sufficient proof is available today to demonstrate that dental pulp tissue engineering is possible. The body of evidence was generated mainly on cell transplantation; however, because of several severe problems afflicted with this approach, it might not be feasible for a clinical setting in the near future. More recently, cell homing has been proposed as a viable alternative. We suggest a modification of the tissue engineering paradigm, where resident cells are attracted by endogenous, dentin-derived growth factors that further induce cell proliferation and differentiation and a bioactive scaffold material laden with these growth factors that serves as a template for tissue formation. This article highlights the latest developments regarding scaffold materials, stem cells, and dentin-derived growth factors specifically for a cell-homing approach to engineer dental pulp and summarizes new ideas. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Yu, Yinxian; Sun, Binbin; Yi, Chengqing; Mo, Xiumei
Tissue engineering focuses on repairing tissue and restoring tissue functions by employing three elements: scaffolds, cells and biochemical signals. In tissue engineering, bioactive material scaffolds have been used to cure tissue and organ defects with stem cell-based therapies being one of the best documented approaches. In the review, different biomaterials which are used in several methods to fabricate tissue engineering scaffolds were explained and show good properties (biocompatibility, biodegradability, and mechanical properties etc.) for cell migration and infiltration. Stem cell homing is a recruitment process for inducing the migration of the systemically transplanted cells, or host cells, to defect sites. The mechanisms and modes of stem cell homing-based tissue engineering can be divided into two types depending on the source of the stem cells: endogenous and exogenous. Exogenous stem cell-based bioactive scaffolds have the challenge of long-term culturing in vitro and for endogenous stem cells the biochemical signal homing recruitment mechanism is not clear yet. Although the stem cell homing-based bioactive scaffolds are attractive candidates for tissue defect therapies, based on in vitro studies and animal tests, there is still a long way before clinical application.
Fifteen students from Turtle Mountain Community College were selected to participate in activities of the RISE project last summer. Eight students successfully completed project activities and received stipends for their participation. These eight students are (1) Jamie Gable, (2) John Morin, (3) Patrick Belgarde, (4) Jason Laducer, (5) Alex Johnson, (6) Eric Houle, (7) Gary Renault, and (8) Kenny DeCoteau. In the fall of 1998, Jamie Gable and Gary Renault went to North Dakota State University to pursue their undergraduate degrees in mechanical engineering, and John Morin and Alex Johnson joined the University of North Dakota's electrical engineering and industrial technology programs, respectively. Remaining four students will continue to participate in the RISE activities this year and transfer to the universities next year. Seven students who failed to complete the RISE project activities during the current award period are encouraged to participate again this fall. The RISE students were enrolled in a special course called "Introduction to Engineering Materials." The project director, Dr. Kamawat, taught the course on Saturdays and Sundays. Theoretical and mathematical background on engineering materials and careers in various engineering professions were discussed in this course. The students attended guest lectures given by engineers and professors and visited local industries. In addition, the students went to North Dakota State University (NDSU) at Fargo, ND, and the University of Minnesota (UMN) at Minneapolis, MN, to tour their engineering departments. At NDSU, they conducted laboratory tests on various engineering materials, such as concrete, steel, wood, plastics, and carbon composites. The students investigated the mechanical behavior of these materials under various loading conditions, collected data, interpreted data, identified possible errors, determined the mechanical properties, and wrote reports on their findings. The students created posters
Remolina-Millán, Aduljay; Hernández-Arroyo, Emil
The organizing committee of The International Congress of Mechanical Engineering and Agricultural Sciences - CIIMCA 2013 - are pleased to present CIIMCA-2013: the first international conference focused on subjects of materials science, mechanical engineering and renewable energy organized by Mechanical Engineering Faculty of the ''Universidad Pontificia Bolivariana'' in Bucaramanga, Colombia. This conference aims to be a place to produce discussions on whole topics of the congress, between the scientists of Colombia and the world. We strongly believe that knowledge is fundamental to the development of our countries. For that reason this multidisciplinary conference is looking forward to integrate engineering, agricultural science and nanoscience and nanotechnology to produce a synergy of this area of knowledge and to achieve scientific and technological developments. Agriculture is a very important topic for our conference; in Colombia, agricultural science needs more attention from the scientific community and the government. In the Faculty of Mechanical Engineering we are beginning to work on these issues to produce knowledge and improve the conditions in our country. The CIIMCA conference is a great opportunity to create interpersonal relationships and networks between scientists around the world. The interaction between scientists is very important in the process of the construction of knowledge. The general chairman encourages and invites you to make friends, relationships and participate strongly in the symposia and all program activities. PhD Aduljay Remolina-Millán Principal Chairman, International Mechanical Engineering and Agricultural Sciences Congress - CIIMCA Msc Emil Hernández-Arroyo Principal Chairman, International Mechanical Engineering and Agricultural Sciences Congress - CIIMCA Conference photograph Conference photograph 'Universidad Pontificia Bolivariana seccional Bucaramanga' host of the first International Mechanical Engineering and
Fox, Derek B; Warnock, Jennifer J
Avascular meniscal injuries are largely incapable of healing; the most common treatment remains partial meniscectomy despite the risk of subsequent osteoarthritis. Meniscal responses to injury are partially mediated through synovial activity and strategies have been investigated to encourage healing through stimulating or transplanting adjacent synovial lining. However, with their potential for chondrogenesis, synovial fibroblast-like stem cells hold promise for meniscal cartilage tissue engineering. Thus, specific purposes of this review were to (1) examine how the synovial intima and synoviomeniscal junction affect current meniscal treatment modalities; and (2) examine the components of tissue engineering (cells, scaffolds, bioactive agents, and bioreactors) in the specific context of how cells of synovial origin may be used for meniscal healing or regeneration. An online bibliographic search through PubMed was performed in March 2010. Studies were subjectively evaluated and reviewed if they addressed the question posed. Fifty-four resources were initially retrieved, which offered information on the chondrogenic potential of synovial-based cells that could prove valuable for meniscal fibrocartilage engineering. Based on the positive effects of adjoining synovium on meniscal healing as used in some current treatment modalities, the chondrogenic potential of fibroblast-like stem cells of synovial origin make this cell source a promising candidate for cell-based tissue engineering strategies. The abundance of autologous synovial lining, its ability to regenerate, and the potential of synovial-derived stem cells to produce a wide spectrum of chondral matrix components make it an ideal candidate for future meniscal engineering investigations.
Hitt, S. J.; Bright, K.
Many educators in the fields of science and engineering assure their students that writing is an important and necessary part of their work. According to David Lindsay, in Scientific Writing=Thinking in Words, 99% of scientists agree that writing is an integral part of their jobs. However, only 5% of those same scientists have ever had formal instruction in scientific writing, and those who are also educators may then feel unconfident in teaching this skill to their students (2). Additionally, making time for writing instruction in courses that are already full of technical content can cause it to be hastily and/or peremptorily included. These situations may be some of the contributing factors to the prevailing attitude of frustration that pervades the conversation about writing in science and engineering classrooms. This presentation provides a summary of past, present, and ongoing Writing Center research on effective writing tutoring in order to give science and engineering educators integrated approaches for working with student writers in their disciplines. From creating assignments, providing instruction, guiding revisions, facilitating peer review, and using assessments, we offer a comprehensive approach to getting your students motivated to improve their writing. Our new research study focuses on developing student writing resources and support in science and engineering institutions, with the goal of utilizing cross-disciplinary knowledge that can be used by the various constituencies responsible for improving the effectiveness of writing among student engineers and scientists. We will will draw upon recent findings in the study of the rhetoric and compositional pedagogy and apply them to the specific needs of the science and engineering classroom. The fields of communication, journalism, social sciences, rhetoric, technical writing, and philosophy of science have begun to integrate these findings into classroom practice, and we will show how these can also
Wendell, Kristen Bethke; Lee, Hee-Sun
Materials science, which entails the practices of selecting, testing, and characterizing materials, is an important discipline within the study of matter. This paper examines how third grade students' materials science performance changes over the course of instruction based on an engineering design challenge. We conducted a case study of nine…
Executive Office of the President, 2016
As called for in the America COMPETES Reauthorization Act of 2010, the National Science and Technology Council's (NSTC) Committee on STEM Education (CoSTEM) released, in May of 2013, the Federal Science, Technology, Engineering, and Mathematics (STEM) Education 5- Year Strategic Plan (Strategic Plan). As required by the Act, this report includes…
O'Brien, James; Rueckert, Franz; Sirokman, Greg
Undergraduate research has become more and more integral to the functioning of higher educational institutions. At many institutions undergraduate research is conducted as capstone projects in the pure sciences, however, science faculty at some schools (including that of the authors) face the challenge of not having science majors. Even at these institutions, a select population of high achieving engineering students will often express a keen interest in conducting pure science research. Since a foray into science research provides the student the full exposure to the scientific method and scientific collaboration, the experience can be quite rewarding and beneficial to the development of the student as a professional. To this end, the authors have been working to find new contexts in which to offer research experiences to non- science majors, including a new undergraduate research class conducted by physics and chemistry faculty. An added benefit is that these courses are inherently interdisciplinary. Students in the engineering and computer science fields step into physics and chemistry labs to solve science problems, often invoking their own relevant expertise. In this paper we start by discussing the common themes and outcomes of the course. We then discuss three particular projects that were conducted with engineering students and focus on how the undergraduate research experience enhanced their already rigorous engineering curriculum.
This research investigates how eight undergraduate African American women in science, math, and engineering (SME) majors accessed cultural capital and informal science learning opportunities from preschool to college. It uses the multiple case study methodological approach and cultural capital as frameworks to better understand the participants'…
A grant was made to install and pilot-test the Science, Engineering and Technology (SET) Career Library Corner at the New York Hall of Science. The SET Career Library Corner is located in a multi-media library setting where visitors can explore careers in a quiet, uninterrupted environment, in contrast to the original installation designed as a museum floor exhibit.
Llego, Jordan Hiso
This study aimed to determine the relationship of emotional intelligence of science STE teachers' with their classroom management. This study used descriptive-correlational using survey questionnaire with total population sampling who are offering Science, Technology and Engineering curriculum in Region 1, Philippines with 113 respondents.…
Regtien, Paulus P.L.; Frollo, I.
At many universities and training institutes education in metrology or measurement science is in strong competition with upcoming disciplines. Its importance for science and engineering remains, however, evident. Advanced instruments make measuring almost a routine activity, but it is shown that a
Carignan, Anastasia; Hussain, Mahjabeen
In this practical arts-integrated science and engineering lesson, an inquiry-based approach was adopted to teach a class of fourth graders in a Midwest elementary school about the scientific concepts of plate tectonics and earthquakes. Lessons were prepared following the 5 E instructional model. Next Generation Science Standards (4-ESS3-2) and the…
Karahan, Engin; Canbazoglu Bilici, Sedef; Unal, Aycin
Problem Statement: Science, technology, engineering and mathematics (STEM) education aims at improving students' knowledge and skills in science and math, and thus their attitudes and career choices in these areas. The ultimate goal in STEM education is to create scientifically literate individuals who can survive in the global economy. The…
Fox, Mary Frank; Sonnert, Gerhard; Nikiforova, Irina
This article focuses upon programs for undergraduate women in science and engineering, which are a strategic research site in the study of gender, science, and higher education. The design involves both quantitative and qualitative approaches, linking theory, method, questions, and analyses in ways not undertaken previously. Using a comprehensive,…
Zoreda, Margaret Lee; Zoreda, Juan Jose
Describes an English-language reading course for science and engineering students at a Mexican university. The course used science and cyberpunk fiction to address moral and ethical issues concerning technological advancement. Synthesizes students' commentaries and includes lists of reading materials, films, and discussion questions. (MJP)
Full Text Available The Cell Broadband Engine architecture is a revolutionary processor architecture well suited for many scientific codes. This paper reports on an effort to implement several traditional high-performance scientific computing applications on the Cell Broadband Engine processor, including molecular dynamics, quantum chromodynamics and quantum chemistry codes. The paper discusses data and code restructuring strategies necessary to adapt the applications to the intrinsic properties of the Cell processor and demonstrates performance improvements achieved on the Cell architecture. It concludes with the lessons learned and provides practical recommendations on optimization techniques that are believed to be most appropriate.
Tadmor, Brigitta; Tidor, Bruce
Progress in the life sciences, including genome sequencing and high-throughput experimentation, offers an opportunity for understanding biology and medicine from a systems perspective. This 'new view', which complements the more traditional component-based approach, involves the integration of biological research with approaches from engineering disciplines and computer science. The result is more than a new set of technologies. Rather, it promises a fundamental reconceptualization of the life sciences based on the development of quantitative and predictive models to describe crucial processes. To achieve this change, learning communities are being formed at the interface of the life sciences, engineering and computer science. Through these communities, research and education will be integrated across disciplines and the challenges associated with multidisciplinary team-based science will be addressed.
Covering the Ancient Greek era, the Middle Ages, the Renaissance, the Enlightenment, the 19th and 20th C., this paper explores the visions of the abilities of women, their access to education, and their roles in these epochs. Recent data on the participation rate of women in science and engineering, the culture in these fields, and strategies to increase their presence are discussed. The paper ends with a discussion on how science and engineering could benefit from integrating and valuing a blend of masculine and feminine perspectives. Biomedical engineering as a field frequently chosen by women is mentioned.
Ozaktas, Haldun M
The course Science, Technology, and Society is taken by about 500 engineering students each year at Bilkent University, Ankara. Aiming to complement the highly technical engineering programs, it deals with the ethical, social, cultural, political, economic, legal, environment and sustainability, health and safety, reliability dimensions of science, technology, and engineering in a multidisciplinary fashion. The teaching philosophy and experiences of the instructor are reviewed. Community research projects have been an important feature of the course. Analysis of teaching style based on a multi-dimensional model is given. Results of outcome measurements performed for ABET assessment are provided. Challenges and solutions related to teaching a large class are discussed.
Moore, John W.; Moore, Elizabeth A., Eds.
Reviews the benefits and hazards of genetic engineering, or "recombinant-DNA" research. Recent federal safety rules issued by NIH which ease the strict prohibitions on recombinant-DNA research are explained. (CS)
Shoureshi, Rahmat A
Engineering has traditionally focused on the external extensions of organisms, such as transportation systems, high-rise buildings, and entertainment systems. In contrast, bioengineering is concerned with inward processes of biologic organisms. Utilization of engineering principles and techniques in the analysis and solution of problems in medicine and biology is the basis for bioengineering. This article discusses subspecialties in bioengineering and presents examples of projects in this discipline.
developments, and maybe even humanity’s grand challenges [ NAE , 2008]) and allows scientists, technologists, engineers, and project managers the opportunity...application (in which case the process is usually executed at the TD level), or cross- and multi-discipline technology solutions (executed at the enterprise...E. Director, United States Air Force Center for Systems Engineering, Wright-Patterson AFB OH. Personal Interview. 21 July 2008. [ NAE , 2008
Taguchi, Tetsushi, E-mail: email@example.com [Biofunctional Materials Unit, Nano-Bio Field, Materials Nanoarchitectonics (MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)
The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissues in vitro and in vivo. Cartilage, bone and skin have been successfully regenerated in vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organs in vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration. (topical review)
The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissues in vitro and in vivo. Cartilage, bone and skin have been successfully regenerated in vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organs in vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration.
Smith, Mason R.; Khera, Eshita; Wen, Fei
Biocatalysts, especially enzymes, have the ability to catalyze reactions with high product selectivity, utilize a broad range of substrates, and maintain activity at low temperature and pressure. Therefore, they represent a renewable, environmentally friendly alternative to conventional catalysts. Most current industrial-scale chemical production processes using biocatalysts employ soluble enzymes or whole cells expressing intracellular enzymes. Cell surface display systems differ by presenting heterologous enzymes extracellularly, overcoming some of the limitations associated with enzyme purification and substrate transport. Additionally, coupled with directed evolution, cell surface display is a powerful platform for engineering enzymes with enhanced properties. In this review, we will introduce the molecular and cellular principles of cell surface display and discuss how it has been applied to engineer enzymes with improved properties as well as to develop surface-engineered microbes as whole-cell biocatalysts. PMID:29056821
Zandvoort, Henk; Bird, Stephanie J.; Børsen, Tom
very limited and seemingly insufficient in view of the enormous ethical and social problems that are associated with current science and technology. Although many social, political and professional organisations have expressed the need for the provision of teaching for social responsibility, important....... If the social responsibility of scientists and engineers implies a duty to safeguard or promote a peaceful, just and sustainable world society, then science and engineering education should empower students to fulfil this responsibility. The contributions to this special issue present European examples...... of teaching social responsibility to students in science and engineering, and provide examples and discussion of how this teaching can be promoted, and of obstacles that are encountered. Speaking generally, education aimed at preparing future scientists and engineers for social responsibility is presently...
Jørgensen, Ulrik; Brodersen, Søsser
Despite contextual knowledge is considered very important for engineers in performing their profession, experiences from decades in Europe and the USA have shown that teaching such topics in engineering education is challenging and often unsuccessful. One of the dilemmas is that social science...... based reflections related to the use and uptake of technology in society often conflicts with engineering students’ self-understanding and identity. Another dilemma is related to the specificity and modeling reductionism in engineering science compared to the complexity of problems in engineering...... practice. Consequently courses added into engineering curricula emphasizing contextual issues stay in stark contrast to the dominant instrumental disciplines of mathematics and techno-science content of core engineering courses. Based on several years of teaching and experimenting with Theory of Science...
The issue of economic globalization and JABEE (Japan Accreditation Board for Engineering Education) mean that education on engineering ethics has now become increasingly important for science-engineering students who will become the next generation of engineers. This is clearly indicated when engineers are made professionally responsible for various unfortunate accidents that happen during daily life in society. Learning hybrid engineering ethics is an essential part of the education of the humanities and sciences. This paper treats the contents for the subject of “Science and Ethics” drawing on several years of practice and the fruits of studying science and engineering ethics at the faculty of science-engineering in university. This paper can be considered to be a practical strategy to the formation of morality.
Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 11. Science Academies' Refresher Course on Cell and Molecular Biology Techniques. Information and Announcements Volume 16 Issue 11 November 2011 pp 1101-1101 ...
Maeng, Jennifer L.; Whitworth, Brooke A.; Gonczi, Amanda L.; Navy, Shannon L.; Wheeler, Lindsay B.
This randomised controlled trial used a mixed-methods approach to investigate the frequency and how elementary teachers integrated engineering design (ED) principles into their science instruction following professional development (PD). The ED components of the PD were aligned with Cunningham and Carlsen's [(2014). "Teaching engineering…
Wu, Shinyi; Duan, Naihua; Wisdom, Jennifer P; Kravitz, Richard L; Owen, Richard R; Sullivan, J Greer; Wu, Albert W; Di Capua, Paul; Hoagwood, Kimberly Eaton
Integrating two distinct and complementary paradigms, science and engineering, may produce more effective outcomes for the implementation of evidence-based practices in health care settings. Science formalizes and tests innovations, whereas engineering customizes and optimizes how the innovation is applied tailoring to accommodate local conditions. Together they may accelerate the creation of an evidence-based healthcare system that works effectively in specific health care settings. We give examples of applying engineering methods for better quality, more efficient, and safer implementation of clinical practices, medical devices, and health services systems. A specific example was applying systems engineering design that orchestrated people, process, data, decision-making, and communication through a technology application to implement evidence-based depression care among low-income patients with diabetes. We recommend that leading journals recognize the fundamental role of engineering in implementation research, to improve understanding of design elements that create a better fit between program elements and local context.
Mathematical models of pancreatic beta cells suggest design principles that can be applied to engineering cells to sense glucose and secrete insulin. Engineering cells can potentially both contribute to future diabetes therapies and generate new insights into beta-cell function. The focus is on ion channels, Ca(2+)handling, and elements of metabolism that combine to produce the varied oscillatory patterns exhibited by beta cells. Copyright 2010. Published by Elsevier Inc.
The American Indian Higher Education Consortium, composed of 35 American Indian tribally-controlled Colleges and Universities in the U.S. and Canada, is leading a comprehensive effort to improve American Indian student achievement in STEM. A key component of this effort is the synthesis of indigenous ways of knowing and western education systems. This presentation will provide an overview of culturally responsive, place-based teaching, learning, and research and will discuss potential opportunities and strategies for helping to ensure that education systems and research programs reflect our diversity and respect our cultures. One example to be discussed is the NSF-funded "Tribal College Rural Systemic Initiative." Founded on the belief that all students can learn and should be given the opportunity to reach their full potential, Tribal Colleges are leading this effort to achieve successful and sustainable improvement of science, math, and technology education at the K-14 level in rural, economically disadvantaged, geographically challenged areas. Working with parents, tribal governments, schools and the private sector, the colleges are helping to implement math and science standards-based curriculum for students and standards-based assessment for schools; provide math and science standards-based professional development for teachers, administrators, and community leaders; and integrate local Native culture into math and science standards-based curriculum. The close working relationship between the Tribal Colleges and K-12 is paying off. According to the National Science Foundation, successful systemic reform has resulted in enhanced student achievement and participation in science and math; reductions in the achievement disparities among students that can be attributed to socioeconomic status, race, ethnicity, gender, or learning styles; implementation of a comprehensive, standards-based curriculum aligned with instructions and assessment; development of a coherent
Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period October 1, 1988 through March 31, 1989 is summarized.
Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science during the period October 1, 1983 through March 31, 1984 is summarized.
Brownstein, Erica M.; Horvath, Larry
Science teacher educators in the United States are currently preparing future science teachers to effectively implement the "Next Generation Science Standards" (NGSS) and, in thirteen states, to successfully pass a content-specific high stakes teacher performance assessment, the edTPA. Science education and teacher performance assessment…
Harry, John Ernest
Written by a university lecturer with more than forty years experience in plasma technology, this book adopts a didactic approach in its coverage of the theory, engineering and applications of technological plasmas. The theory is developed in a unified way to enable brevity and clarity, providing readers with the necessary background to assess the factors that affect the behavior of plasmas under different operating conditions. The major part of the book is devoted to the applications of plasma technology and their accompanying engineering aspects, classified by the various pressure and densit
Larsen, Morten Nørgaard; Skovhede, Kenneth; Vinter, Brian
in and out of non-coherent local storage blocks for each special processor element. In this paper we present a software library, namely the Distributed Shared Memory for the Cell Broadband Engine (DSMCBE). By using techniques known from distributed shared memory DSMCBE allows programmers to program the CELL...
Full Text Available The concept of bandgap science of organic semiconductor films for use in photovoltaic cells, namely, high-purification, pn-control by doping, and design of the built-in potential based on precisely-evaluated doping parameters, is summarized. The principle characteristics of organic solar cells, namely, the exciton, donor (D/acceptor (A sensitization, and p-i-n cells containing co-deposited and D/A molecular blended i-interlayers, are explained. ‘Seven-nines’ (7N purification, together with phase-separation/cystallization induced by co-evaporant 3rd molecules allowed us to fabricate 5.3% efficient cells based on 1 µm-thick fullerene:phthalocyanine (C60:H2Pc co-deposited films. pn-control techniques enabled by impurity doping for both single and co-deposited films were established. The carrier concentrations created by doping were determined by the Kelvin band mapping technique. The relatively high ionization efficiency of 10% for doped organic semiconductors can be explained by the formation of charge transfer (CT-complexes between the dopants and the organic semiconductor molecules. A series of fundamental junctions, such as Schottky junctions, pn-homojunctions, p+, n+-organic/metal ohmic junctions, and n+-organic/ p+-organic ohmic homojunctions, were fabricated in both single and co-deposited organic semiconductor films by impurity doping alone. A tandem cell showing 2.4% efficiency was fabricated in which the built-in electric field was designed by manipulating the doping.
Oman, H.; Gregory, D. L.
A solar power satellite is the energy-converting element of a system that can deliver some 10 GW of power to utilities on the earth's surface. We evaluated heat engines and solar cells for converting sunshine to electric power at the satellite. A potassium Rankine cycle was the best of the heat engines, and 50 microns thick single-crystal silicon cells were the best of the photovoltaic converters. Neither solar cells nor heat engines had a clear advantage when all factors were considered. The potassium-turbine power plant, however, was more difficult to assemble and required a more expensive orbital assembly base. We therefore based our cost analyses on solar-cell energy conversion, concluding that satellite-generated power could be delivered to utilities for around 4 to 5 cents a kWh.
Wang, Baojun; Barahona, Mauricio; Buck, Martin; Schumacher, Jörg
Bacterial cells continuously sense and respond to their environment using their inherent signalling and gene regulatory networks. Cells are equipped with parallel signalling pathways, which can specifically cope with individual input signals, while interconnectivities between pathways lead to an enhanced complexity of regulatory responses that enable sophisticated adaptation. In principle, any cell signalling pathway may be rewired to respond to non-cognate signals by exchanging and recombining their underlying cognate signalling components. In the present article, we review the engineering strategies and use of chimaeric regulatory proteins in cell signalling pathways, especially the TCS (two-component signalling) system in bacteria, to achieve novel customized signalling or regulatory functions. We envisage that engineered chimaeric regulatory proteins can play an important role to aid both forward and reverse engineering of biological systems for many desired applications.
Moore, Simon J; MacDonald, James T; Freemont, Paul S
Cell-free transcription-translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical test kits for on-site identification of viruses (Zika and Ebola), while gene circuit cascades can be tested, debugged and re-designed within rapid turnover times. Coupled with mathematical modelling, this discipline lends itself towards the precision engineering of new synthetic life. The next stages of cell-free look set to unlock new microbial hosts that remain slow to engineer and unsuited to rapid iterative design cycles. It is hoped that the development of such systems will provide new tools to aid the transition from cell-free prototype designs to functioning synthetic genetic circuits and engineered natural product pathways in living cells. © 2017 The Author(s).
Brown, Susan Wightman
National statistics clearly demonstrate an underrepresentation of minorities in the fields of science and engineering. Blacks, Hispanics, American Indians, and Asians do not typically choose science or engineering as their college major; therefore, there is a very small representation of these minorities in the science and engineering labor force. The decision not to major in science and engineering may begin as soon as the child can begin to recognize role models in the media. News stories, magazine articles, television programs, teachers, parents, administrators, and other agencies have painted the picture of a scientist or engineer as being dominantly a White male. Schools have continued society's portrayal by using curriculum, textbooks, role models, instructional strategies, and counseling that continues to encourage the White male to succeed in science and engineering, but discourages the minority students, male and female, from succeeding in these fields. In this qualitative study, 22 Hispanic students, 12 female and 10 male, who are majoring in science or engineering, were interviewed using Seidman's in-depth interviewing technique. These students were shadowed in their college science or engineering classes; their high school and college transcripts were analyzed; and, a focus group was brought together at the end of the interviewing process in order to allow interaction between the participants. The goal was to explore the educational journeys of the 22 Hispanic students. What made a difference in the journeys of these 22 students so that they could succeed in majors that have historically discouraged minority students? Seven themes emerged: family support, honors program, challenging and interactive curriculum, college preparation in high school courses, caring and kind teachers, small class size, and small communities. Gender comparison of the educational journeys documents these differences between the females and males: college preparation, mentoring
Zhang, Zhang; Qiu, Shunfang; Zhang, Xiaopeng; Chen, Wei
Effective gene-delivery systems for primary human T cell engineering are useful tools for both basic research and clinical immunotherapy applications. Pseudovirus-based systems and electro-transfection are the most popular strategies for genetic material transduction. Compared with viral-particle-mediated approaches, electro-transfection is theoretically safer, because it does not promote transgene integration into the host genome. Additionally, the simplicity and speed of the procedure increases the attractiveness of electroporation. Here, we developed and optimized an electro-transfection method for the production of engineered chimeric antigen receptor (CAR)-T cells. Stimulation of T cells had the greatest effect on their transfection, with stimulation of cells for up to 3 days substantially improving transfection efficiency. Additionally, the strength of the external electric field, input cell number, and the initial amount of DNA significantly affected transfection performance. The voltage applied during electroporation affected plasmid permeation and was negatively correlated with the number of viable cells after electroporation. Moreover, higher plasmid concentration increased the proportion of positively transfected cells, but decreased cell viability, and for single-activated cells, higher cell density enhanced their viability. We evaluated the effects of two clinically relevant factors, serum supplementation in the culture medium and cryopreservation immediately after the isolation of peripheral blood lymphocytes. Our findings showed that our protocol performed well using xeno-free cultured, fresh T cells, with application resulting in a lower but acceptable transfection efficiency of cells cultured with fetal bovine serum or thawed cells. Furthermore, we described an optimized procedure to generate CAR-T cells within 6 days and that exhibited cytotoxicity toward targeted cells. Our investigation of DNA electro-transfection for the use in human primary
Effect of injection timing and injection pressure on the performance of biodiesel ester of hongeoil fuelled common rail direct injection (CRDI) engine · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. M.R. Indudhar, N.R. Banapurmath, K Govinda Rajulu, S.V. Khandal ...
Aharoni, A.; Jongsma, M.A.; Bouwmeester, H.J.
Terpenoids are important for plant survival and also possess biological properties that are beneficial to humans. Here, we describe the state of the art in terpenoid metabolic engineering, showing that significant progress has been made over the past few years. Subcellular targeting of enzymes has
all solution – Engineering skills/judgment still need to be used – Avoid a checklist mentality 20 Future Steady State • Programs utilizing MRLs...1 Corps Prep 22 CTC Spt 2 Div + 1 Corps MRXs 144 DSE Tool Kits 148K CD Images 13K DVD Images 225 Cable Shop WO 1821 Cables Produced 335 Units
Smith, Karianne; Hughes, William
In the fall of 2011, Park Forest Middle School (PFMS) students approached the STEM faculty with numerous questions regarding the popular television show Myth Busters, which detailed Greek mathematician, physicist, engineer, and inventor, Archimedes. Two episodes featured attempts to test historical accounts that Archimedes developed a death ray…
Fast predictive control for air-fuel ratio of SI engines using a nonlinear internal model · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. YJ Zhai, DL Yu, R Tafreshi, Y Al-Hamidi, 1-17. http://dx.doi.org/10.4314/ijest.v3i6.1S ...
Selcen Guzey, S.; Harwell, Michael; Moreno, Mario; Peralta, Yadira; Moore, Tamara J.
The new science education reform documents call for integration of engineering into K-12 science classes. Engineering design and practices are new to most science teachers, meaning that implementing effective engineering instruction is likely to be challenging. This quasi-experimental study explored the influence of teacher-developed, engineering design-based science curriculum units on learning and achievement among grade 4-8 students of different races, gender, special education status, and limited English proficiency (LEP) status. Treatment and control students ( n = 4450) completed pretest and posttest assessments in science, engineering, and mathematics as well as a state-mandated mathematics test. Single-level regression results for science outcomes favored the treatment for one science assessment (physical science, heat transfer), but multilevel analyses showed no significant treatment effect. We also found that engineering integration had different effects across race and gender and that teacher gender can reduce or exacerbate the gap in engineering achievement for student subgroups depending on the outcome. Other teacher factors such as the quality of engineering-focused science units and engineering instruction were predictive of student achievement in engineering. Implications for practice are discussed.
Burke, M. P.; Linn, F.
Partnerships between science professionals in the community and professional educators can help facilitate the adoption of the Next Generation Science Standards (NGSS). Classroom teachers have been trained in content areas but may be less familiar with the new required Science and Engineering component of the NGSS. This presentation will offer a successful model for building classroom and community partnerships and highlight the particulars of a collaborative lesson taught to Rapid City High School students. Local environmental issues provided a framework for learning activities that encompassed several Crosscutting Concepts and Science and Engineering Practices for a lesson focused on Life Science Ecosystems: Interactions, Energy, and Dynamics. Specifically, students studied local water quality impairments, collected and measured stream samples, and analyzed their data. A visiting hydrologist supplied additional water quality data from ongoing studies to extend the students' datasets both temporally and spatially, helping students to identify patterns and draw conclusions based on their findings. Context was provided through discussions of how science professionals collect and analyze data and communicate results to the public, using an example of a recent bacterial contamination of a local stream. Working with Rapid City High School students added additional challenges due to their high truancy and poverty rates. Creating a relevant classroom experience was especially critical for engaging these at-risk youth and demonstrating that science is a viable career path for them. Connecting science in the community with the problem-solving nature of engineering is a critical component of NGSS, and this presentation will elucidate strategies to help prospective partners maneuver through the challenges that we've encountered. We recognize that the successful implementation of the NGSS is a challenge that requires the support of the scientific community. This partnership
Kasper, Cornelia [Hannover Univ. (Germany). Inst. fuer Technische Chemie; Griensven, Martijn van [Ludwig Boltzmann Institut fuer Klinische und Experimentelle Traumatologie, Wien (Austria); Poertner, Ralf (eds.) [Technische Univ. Hamburg-Harburg (Germany). Inst. Biotechnologie und Verfahrenstechnik
Alternative Sources of Adult Stem Cells: Human Amniotic Membrane, by S. Wolbank, M. van Griensven, R. Grillari-Voglauer, and A. Peterbauer-Scherb; - Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications, by P. Moretti, T. Hatlapatka, D. Marten, A. Lavrentieva, I. Majore, R. Hass and C. Kasper; - Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells, by J. W. Kuhbier, B. Weyand, C. Radtke, P. M. Vogt, C. Kasper and K. Reimers; - Induced Pluripotent Stem Cells: Characteristics and Perspectives, by T. Cantz and U. Martin; - Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology, by D. Pei, J. Xu, Q. Zhuang, H.-F. Tse and M. A. Esteban; - Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells, by C. Weber, S. Pohl, R. Poertner, P. Pino-Grace, D. Freimark, C. Wallrapp, P. Geigle and P. Czermak; - Cartilage Engineering from Mesenchymal Stem Cells, by C. Goepfert, A. Slobodianski, A.F. Schilling, P. Adamietz and R. Poertner; - Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine, by S. Fuchs, E. Dohle, M. Kolbe, C. J. Kirkpatrick; - Basic Science and Clinical Application of Stem Cells in Veterinary Medicine, by I. Ribitsch, J. Burk, U. Delling, C. Geissler, C. Gittel, H. Juelke, W. Brehm; - Bone Marrow Stem Cells in Clinical Application: Harnessing Paracrine Roles and Niche Mechanisms, by R. M. El Backly, R. Cancedda; - Clinical Application of Stem Cells in the Cardiovascular System, C. Stamm, K. Klose, Y.-H. Choi. (orig.)
What do Remotely Operated Vehicles (ROVs), Ocean Science, Engineering and Technology have in common with science education in today's classroom? They all meet the growing demand for science, technology, engineering, and mathematics (STEM) professionals in tomorrow's U.S. workforce. Engaging students in real world science experiences will help them develop skills such as critical thinking, problem solving, collaboration, communication, innovation, and creativity. These skills are crucial to building a strong, competitive workforce in an integrated global economy. Fifth grade students from St. Andrew's School of Math and Science in Charleston, SC, USA science classes were introduced to engineering and robotics by using a combination of two underwater ROVs programs from the Office of Naval Research (SeaPerch) and Marine Advanced Technology Education (MATE). Students were grouped in teams as "real scientists" to design and construct a ROV. Students selected their role from a list of engineering positions, and researched how to construct the best ROV. Students created blueprints and models of their ROV design. Scientists/engineers from various local agencies were scheduled to come and share their expertise with the students. On World Ocean Day, a presentation was planned for fifth grade students to work closely with kindergarten through fourth grade students. The purpose of the day was two-fold; it provided students the opportunity to peer teach and the opportunity to present their experiences to a wide audience. All students presented their designs and demonstrated their ROV's movement capabilities in child size pools. They also modeled how submersible pilots communicate with scientists and other researchers while operating their newly designed ROV. As a culminating event, students visited a local marine science high school class with similar ROVs and evaluated their engineering designs in a fresh water pond.
Langville, Amy N
Why doesn't your home page appear on the first page of search results, even when you query your own name? How do other Web pages always appear at the top? What creates these powerful rankings? And how? The first book ever about the science of Web page rankings, Google's PageRank and Beyond supplies the answers to these and other questions and more. The book serves two very different audiences: the curious science reader and the technical computational reader. The chapters build in mathematical sophistication, so that the first five are accessible to the general academic reader. While other cha
Pan, Yuelong; Zheng, Shu
The microencapsulated genetic cells may be a new platform instead of genetic engineering drugs, as they can overcome the genetic engineering drugs' shortages such as short half-life in vivo, low activity, and incomplete elimination of organic solvent. This article reviews and summarizes the advantages, possible problems and solution and the feasibility of using microencapsulated genetic engineering cells in the treatment of cancer.
This Proceedings Volume includes the technical papers that were presented during the Sixteenth Symposium on Energy Engineering Sciences on May 13--15, 1998, at Argonne National Laboratory, Argonne, Illinois. The Symposium was structured into eight technical sessions, which included 30 individual presentations followed by discussion and interaction with the audience. A list of participants is appended to this volume. The DOE Office of Basic Energy Sciences (BES), of which Engineering Research is a component program, is responsible for the long-term, mission-oriented research in the Department. The Office has prime responsibility for establishing the basic scientific foundation upon which the Nation's future energy options will be identified, developed, and built. BES is committed to the generation of new knowledge necessary to solve present and future problems regarding energy exploration, production, conversion, and utilization, while maintaining respect for the environment. Consistent with the DOE/BES mission, the Engineering Research Program is charged with the identification, initiation, and management of fundamental research on broad, generic topics addressing energy-related engineering problems. Its stated goals are to improve and extend the body of knowledge underlying current engineering practice so as to create new options for enhancing energy savings and production, prolonging the useful life of energy-related structures and equipment, and developing advanced manufacturing technologies and materials processing. The program emphasis is on reducing costs through improved industrial production and performance and expanding the nation's store of fundamental knowledge for solving anticipated and unforeseen engineering problems in energy technologies. To achieve these goals, the Engineering Research Program supports approximately 130 research projects covering a broad spectrum of topics that cut across traditional engineering disciplines. The program
Olds, S. E.; Mooney, M. E.; Dahlman, L. E.
Recreational drones, also known as unmanned aerial vehicles (UAVs), provide an ideal platform for engaging students in science, technology, engineering, and math (STEM) investigations for science fair projects, after-school clubs, and in-class activities. UAVs are very popular (estimate of >1 million received as gifts this past year), relatively inexpensive (drones to facilitate experiments, students also participate in engineering design: they may choose off-the-shelf sensors or build DIY sensors to carry on their UAVs. Leveraging the learning potential of UAVs, the Federation of Earth Science Information Partners (ESIP) Education Committee has been developing an e-book of learning activities and investigation suggestions for secondary education students. The freely available download incorporates UAV civility and safety through a pre-flight checklist and flying guidelines, suggests science and flight team roles, and advocates robust data and metadata-collection practices. The ESIP team also worked with an engineer to build a 33-gram prototype environmental logger called SABEL (Shelley (Olds) and Bob's Environmental Logger). SABEL collects temperature, humidity, and GPS position assembled on an Arduino board. This presentation will elaborate upon the year-long process of working with educators via webinars and a 1-day workshop at the 2016 ESIP summer meeting and beyond. It will also provide examples of student-led investigations, instructions for building the SABEL sensor package, insights gleaned from workshop feedback - and - the status of the new e-book compilation of student-focused activities using recreational drones to pursue STEM investigations!
Leung, Dennis YC
Fuel cells are clean and efficient energy conversion devices expected to be the next generation power source. During more than 17 decades of research and development, various types of fuel cells have been developed with a view to meet the different energy demands and application requirements. Scientists have devoted a great deal of time and effort to the development and commercialization of fuel cells important for our daily lives. However, abundant issues, ranging from mechanistic study to system integration, still need to be figured out before massive applications can be used. Miniaturizatio
Cersonsky, Rose K.; Foster, Leanna L.; Ahn, Taeyong; Hall, Ryan J.; van der Laan, Harry L.; Scott, Timothy F.
Despite the prevalence of polymers in modern everyday life, there is little introduction to the topic in science education throughout primary or secondary schooling in the United States. Of the few states that do include polymer education, this is only found at the high school level, primarily in biology or chemistry. Over the past year, we have…
On an improved method for solving evolution equations of higher order importantly in science and technology · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. A Huber, 1-12. http://dx.doi.org/10.4314/ijest.v2i5.60090 ...
Ehrlinger, Joyce; Plant, E Ashby; Hartwig, Marissa K; Vossen, Jordan J; Columb, Corey J; Brewer, Lauren E
Women are vastly underrepresented in the fields of computer science and engineering (CS&E). We examined whether women might view the intellectual characteristics of prototypical individuals in CS&E in more stereotype-consistent ways than men might and, consequently, show less interest in CS&E. We asked 269 U.S. college students (187, 69.5% women) to describe the prototypical computer scientist (Study 1) or engineer (Study 2) through open-ended descriptions as well as through a set of trait ratings. Participants also rated themselves on the same set of traits and rated their similarity to the prototype. Finally, participants in both studies were asked to describe their likelihood of pursuing future college courses and careers in computer science (Study 1) or engineering (Study 2). Across both studies, we found that women offered more stereotype-consistent ratings than did men of the intellectual characteristics of prototypes in CS (Study 1) and engineering (Study 2). Women also perceived themselves as less similar to the prototype than men did. Further, the observed gender differences in prototype perceptions mediated the tendency for women to report lower interest in CS&E fields relative to men. Our work highlights the importance of prototype perceptions for understanding the gender gap in CS&E and suggests avenues for interventions that may increase women's representation in these vital fields.
Cells are open complex thermodynamic systems. Energy transformations, thermo-electro-chemical processes and transports occur across the cells membranes. Different thermo-electro-biochemical behaviours occur between health and disease states. Moreover, living systems waste heat, the result of the internal irreversibility. This heat is dissipated into the environment. But, this wasted heat represent a sort of information, which outflows from the cell toward its environment, completely accessibl...
We will discuss the connectivity of educational systems in the College of Arts and Sciences and the Faculty of Engineering in the University of Tokyo. Students entering the University of Tokyo are enrolled for the first two years in the College of Arts and Sciences, since specialized instruction should be erected on top of broad knowledge and understanding. The University is offering several new types of lecture such as Global Focus on Knowledge (Lecture series where leading scholars in several fields overview sciences mainly for freshmen) in order to lead freshmen into the broad and systematic “structuring of knowledge” . The Faculty of Engineering also tries several new series of (teaching) courses, for example, Knowledge Structuring, Engineering Minimum Lecture Series, MONOZUKURI Experiment, English Language Lessons etc., together with Electrical Syllabi System with MIMASearch.
Sulaiman, Norasrudin; Adnan, Rahmat
The proceeding is a collection of research papers presented at the 2nd International Colloquium on Sports Science, Exercise, Engineering and Technology (ICoSSEET2015), a conference dedicated to address the challenges in the areas of sports science, exercise, sports engineering and technology including other areas of sports, thereby presenting a consolidated view to the interested researchers in the aforesaid fields. The goal of this conference was to bring together researchers and practitioners from academia and industry to focus on the scope of the conference and establishing new collaborations in these areas. The topics of interest are in mainly (1) Sports and Exercise Science (2) Sports Engineering and Technology Application (3) Sports Industry and Management.
This essay develops a new conceptual framework of science and engineering ethics education based on virtue ethics and positive psychology. Virtue ethicists and positive psychologists have argued that current rule-based moral philosophy, psychology, and education cannot effectively promote students' moral motivation for actual moral behavior and may even lead to negative outcomes, such as moral schizophrenia. They have suggested that their own theoretical framework of virtue ethics and positive psychology can contribute to the effective promotion of motivation for self-improvement by connecting the notion of morality and eudaimonic happiness. Thus this essay attempts to apply virtue ethics and positive psychology to science and engineering ethics education and to develop a new conceptual framework for more effective education. In addition to the conceptual-level work, this essay suggests two possible educational methods: moral modeling and involvement in actual moral activity in science and engineering ethics classes, based on the conceptual framework.
Full Text Available We have fabricated new types of polymer hydrogels and polymer nanocomposites, i.e., nanocomposite gels (NC gels and soft, polymer nanocomposites (M-NCs: solid, with novel organic/inorganic network structures. Both NC gels and M-NCs were synthesized by in-situ free-radical polymerization in the presence of exfoliated clay platelets in aqueous systems and were obtained in various forms such as film, sheet, tube, coating, etc. and sizes with a wide range of clay contents. Here, disk-like inorganic clay nanoparticles act as multi-functional crosslinkers to form new types of network systems. Both NC gels and M-NCs have extraordinary optical and mechanical properties including ultra-high reversible extensibility, as well as a number of new characteristics relating to optical anisotropy, polymer/clay morphology, biocompatibility, stimuli-sensitive surfaces, micro-patterning, etc. For examples, the biological testing of medical devices, comprised of a sensitization test, an irritation test, an intracutaneous test and an in vitro cytotoxicity test,was carried out for NC gels and M-NCs. The safety of NC gels and M-NCs was confirmed in all tests. Also, the interaction of living tissue with NC gel was investigated in vivo by implantation in live goats; neither inflammation nor concrescence occurred around the NC gels. Furthermore, it was found that both N-NC gels consisting of poly(N-isopropylacrylamide(PNIPA/clay network and M-NCs consisting of poly(2-methoxyethyacrylate(PMEA/clay network show characteristic cell culture and subsequent cell detachment on their surfaces, although it was almost impossible to culture cells on conventional, chemically-crosslinked PNIPA hydrogels and chemically crossslinked PMEA, regardless of their crosslinker concentration. Various kinds of cells, such ashumanhepatoma cells (HepG2, normal human dermal fibroblast (NHDF, and human umbilical vein endothelial cells (HUVEC, could be cultured to be confluent on the surfaces of N
Chan, Xin Yi; Elliott, Morgan B; Macklin, Bria; Gerecht, Sharon
Development of pluripotent stem cells (PSCs) is a remarkable scientific advancement that allows scientists to harness the power of regenerative medicine for potential treatment of disease using unaffected cells. PSCs provide a unique opportunity to study and combat cardiovascular diseases, which continue to claim the lives of thousands each day. Here, we discuss the differentiation of PSCs into vascular cells, investigation of the functional capabilities of the derived cells, and their utilization to engineer microvascular beds or vascular grafts for clinical application. Graphical Abstract Human iPSCs generated from patients are differentiated toward ECs and perivascular cells for use in disease modeling, microvascular bed development, or vascular graft fabrication.
Lakshmikantham, Vangipuram; Chui, Charles K; Chui, Charles K
The book "Computational Error and Complexity in Science and Engineering pervades all the science and engineering disciplines where computation occurs. Scientific and engineering computation happens to be the interface between the mathematical model/problem and the real world application. One needs to obtain good quality numerical values for any real-world implementation. Just mathematical quantities symbols are of no use to engineers/technologists. Computational complexity of the numerical method to solve the mathematical model, also computed along with the solution, on the other hand, will tell us how much computation/computational effort has been spent to achieve that quality of result. Anyone who wants the specified physical problem to be solved has every right to know the quality of the solution as well as the resources spent for the solution. The computed error as well as the complexity provide the scientific convincing answer to these questions. Specifically some of the disciplines in which the book w...
Lymperi, S; Ligoudistianou, C; Taraslia, V; Kontakiotis, E; Anastasiadou, E
Tooth loss or absence is a common condition that can be caused by various pathological circumstances. The replacement of the missing tooth is important for medical and aesthetic reasons. Recently, scientists focus on tooth tissue engineering, as a potential treatment, beyond the existing prosthetic methods. Tooth engineering is a promising new therapeutic approach that seeks to replace the missing tooth with a bioengineered one or to restore the damaged dental tissue. Its main tool is the stem cells that are seeded on the surface of biomaterials (scaffolds), in order to create a biocomplex. Several populations of mesenchymal stem cells are found in the tooth. These different cell types are categorized according to their location in the tooth and they demonstrate slightly different features. It appears that the dental stem cells isolated from the dental pulp and the periodontal ligament are the most powerful cells for tooth engineering. Additional research needs to be performed in order to address the problem of finding a suitable source of epithelial stem cells, which are important for the regeneration of the enamel. Nevertheless, the results of the existing studies are encouraging and strongly support the belief that tooth engineering can offer hope to people suffering from dental problems or tooth loss.
This book provides a multifaceted look into the world of stem cells and explains the similarities and differences between plant and human stem cells. It explores the intersection between animals and plants and explains their cooperative role in bioengineering studies. The book treats both theoretical and practical aspects of stem cell research. It covers the advantages and limitations of many common applications related to stem cells: their sources, categories, engineering of these cells, reprogramming of their functions, and their role as novel cellular therapeutic approach. Written by experts in the field, the book focuses on aspects of stem cells ranging from expansion-propagation to metabolic reprogramming. It introduces the emergence of cancer stem cells and different modalities in targeted cancer stem cell therapies. It is a valuable source of fresh information for academics and researchers, examining molecular mechanisms of animal and plant stem cell regulation and their usage for therapeutic applicati...
Shen, Xun; Wijk, Roeland Van
... in living cells and living organisms. Fluorescence, scattering and penetrating light are frequently used to detect and image the biological systems at molecular, cellular and organismic levels. The light generated by metabolic processes in living organisms also provides a good optical means to reflect the structure and function of the living cells a...
Huang, Guoyou; Wang, Lin; Wang, Shuqi; Han, Yulong; Wu, Jinhui; Zhang, Qiancheng; Xu, Feng; Lu, Tian Jian
Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as spreading, migration, proliferation and differentiation. However, most studies on cell response to mechanical stimulation are based on two-dimensional (2D) planar substrates, which cannot mimic native three-dimensional (3D) CMM. Accumulating evidence has shown that there is a significant difference in cell behavior in 2D and 3D microenvironments. Among the materials used for engineering 3D CMM, hydrogels have gained increasing attention due to their tunable properties (e.g. chemical and mechanical properties). In this paper, we provide an overview of recent advances in engineering hydrogel-based 3D CMM. Effects of mechanical cues (e.g. hydrogel stiffness and externally induced stress/strain in hydrogels) on cell behaviors are described. A variety of approaches to load mechanical stimuli in 3D hydrogel-based constructs are also discussed.
Esensten, Jonathan H; Bluestone, Jeffrey A; Lim, Wendell A
Engineered T cells are currently in clinical trials to treat patients with cancer, solid organ transplants, and autoimmune diseases. However, the field is still in its infancy. The design, and manufacturing, of T cell therapies is not standardized and is performed mostly in academic settings by competing groups. Reliable methods to define dose and pharmacokinetics of T cell therapies need to be developed. As of mid-2016, there are no US Food and Drug Administration (FDA)-approved T cell therapeutics on the market, and FDA regulations are only slowly adapting to the new technologies. Further development of engineered T cell therapies requires advances in immunology, synthetic biology, manufacturing processes, and government regulation. In this review, we outline some of these challenges and discuss the contributions that pathologists can make to this emerging field.
University Foundation courses in Engineering were run for the first time in the 1988-9 academic year. The Science and the Engineering faculties at Loughborough University of Technology instigated a Foundation Programme in Science and Engineering at the start of the 1991-2 academic year. Of the 100 or so students on the programme four on average go on to continue their studies in physics. This year sees the first two graduates in the physics department to have come via the Foundation route. One studied PE, Sports Science and Physics and the other Engineering Physics. Both of them achieved lower second class honours degrees. There is an extremely heterogeneous intake into the Foundation Programme and a multitude of exit routes, currently up to 30 different science or engineering degrees. These two factors provide interesting challenges to the course planners in terms of both the choice of course content and the teaching styles adopted. The lecturer responsible for the physics input to the programme believes that the use of Resource- Based Learning materials may be a partial solution to the problems faced by students with non-standard entry qualifications. Such materials are being produced by the FLAP (Flexible Learning Approach to Physics) team, of which she has been a member since 1989. The Foundation Programme continues to evolve and is being redesigned to fit the University's plans for semesterization, which will be put into effect from October 1995.
Kolmos, Anette; Holgaard, Jette Egelund
At the Faculty of Engineering and Science at Aalborg University, Denmark, process skills are an integrated part of the curriculum objectives. During the first year programme, a special course in Collaboration, Learning and Project Management (CLP) is given to develop those skills. In order to dev...... and more importantly enhance critical thinking on the actions taken.......At the Faculty of Engineering and Science at Aalborg University, Denmark, process skills are an integrated part of the curriculum objectives. During the first year programme, a special course in Collaboration, Learning and Project Management (CLP) is given to develop those skills. In order...
Sayal, Rishi; Rawat, Sandeep
The book is a collection of high-quality peer-reviewed research papers presented at the third International Conference on Innovations in Computer Science and Engineering (ICICSE 2015) held at Guru Nanak Institutions, Hyderabad, India during 7 – 8 August 2015. The book discusses a wide variety of industrial, engineering and scientific applications of the emerging techniques. Researchers from academic and industry present their original work and exchange ideas, information, techniques and applications in the field of Communication, Computing, and Data Science and Analytics.
Kumar, Ashok; Annamalai, Annamalai
This book is the proceedings of Third International Conference on Computational Science, Engineering and Information Technology (CCSEIT-2013) that was held in Konya, Turkey, on June 7-9. CCSEIT-2013 provided an excellent international forum for sharing knowledge and results in theory, methodology and applications of computational science, engineering and information technology. This book contains research results, projects, survey work and industrial experiences representing significant advances in the field. The different contributions collected in this book cover five main areas: algorithms, data structures and applications; wireless and mobile networks; computer networks and communications; natural language processing and information theory; cryptography and information security.
Richard B. Freeman; Emily Jin; Chia-Yu Shen
This study shows that the demographic and institutional origins of new US trained science and engineering PhDs changed markedly between the late 1960s-1970s to the 1990s-early 2000s. In 1966, 71% of science and engineering PhD graduates were US-born males, 6% were US-born females, and 23% were foreign born. In 2000, 36% of the graduates were US-born males, 25% were US-born females, and 39% were foreign born. Between 1970 and 2000 most of the growth in PhDs was in less prestigious smaller doct...
Sayal, Rishi; Rawat, Sandeep
The book is a collection of high-quality peer-reviewed research papers presented at the Fourth International Conference on Innovations in Computer Science and Engineering (ICICSE 2016) held at Guru Nanak Institutions, Hyderabad, India during 22 – 23 July 2016. The book discusses a wide variety of industrial, engineering and scientific applications of the emerging techniques. Researchers from academic and industry present their original work and exchange ideas, information, techniques and applications in the field of data science and analytics, artificial intelligence and expert systems, mobility, cloud computing, network security, and emerging technologies.
Alicki, Robert; Gelbwaser-Klimovsky, David; Szczygielski, Krzysztof
Solar cells are engines converting energy supplied by the photon flux into work. All known types of macroscopic engines and turbines are also self-oscillating systems which yield a periodic motion at the expense of a usually non-periodic source of energy. The very definition of work in the formalism of quantum open systems suggests the hypothesis that the oscillating ‘piston’ is a necessary ingredient of the work extraction process. This aspect of solar cell operation is absent in the existing descriptions and the main goal of this paper is to show that plasma oscillations provide the physical implementation of a piston.
Wang, Fangyuan; Qi, Lei S
Recent advances in genome engineering are starting a revolution in biological research and translational applications. The clustered regularly interspaced short palindromic repeats (CRISPR)-associated RNA-guided endonuclease CRISPR associated protein 9 (Cas9) and its variants enable diverse manipulations of genome function. In this review, we describe the development of Cas9 tools for a variety of applications in cell biology research, including the study of functional genomics, the creation of transgenic animal models, and genomic imaging. Novel genome engineering methods offer a new avenue to understand the causality between the genome and phenotype, thus promising a fuller understanding of cell biology. Copyright © 2016 Elsevier Ltd. All rights reserved.
Pomazan, Valentina; Mihalaşcu, Doina; Petcu, Lucian C.; Gîrtu, Mihai A.
We report the results of the student responses to a survey aiming to determine the factors influencing the young generation in choosing a career in science and technology. The goal of the study is twofold: to identify the motives that determine students to enroll in university programs in science and technology and to engage in applied science and engineering careers and to discover the barriers that manifest at different age levels, preventing students from making such choices. The study was conducted at the Ovidius University and the "Energetic" Technical High School, both in Constanta, Romania, with samples of 257 and 106 students respectively, based on a 38 item online questionnaire. The samples selected from the student population allow for a wide range of analyses with respect to gender, family and educational background, field of study, etc. We discuss the role of the raw models, parents, educators, and we comment on ways to increase student enrollment in science and engineering.
Stahl, H. Philip; Postman, Marc; Mosier, Gary; Smith, W. Scott; Blaurock, Carl; Ha, Kong; Stark, Christopher C.
The Advance Mirror Technology Development (AMTD) project is in Phase 2 of a multiyear effort, initiated in FY12, to mature by at least a half TRL step six critical technologies required to enable 4 meter or larger UVOIR space telescope primary mirror assemblies for both general astrophysics and ultra-high contrast observations of exoplanets. AMTD uses a science-driven systems engineering approach. We mature technologies required to enable the highest priority science AND provide a high-performance low-cost low-risk system. To give the science community options, we are pursuing multiple technology paths. A key task is deriving engineering specifications for advanced normal-incidence monolithic and segmented mirror systems needed to enable both general astrophysics and ultra-high contrast observations of exoplanets missions as a function of potential launch vehicles and their mass and volume constraints. A key finding of this effort is that the science requires an 8 meter or larger aperture telescope
In order to compete in the global economy, the United States needs to adequately train an increasing number of students in the STEM (Science, Technology, Engineering, and Mathematics) fields. Recent studies show that the U.S. is lagging behind other countries in international science and mathematics assessments, and that the motivation of students to enter into and stay in the STEM fields of study is low. Businesses and government alike are pushing for increased instruction in science and math for K-12 students as a means for producing larger numbers of STEM ready students. New approaches to adding more engineering instruction into the curriculum are being applied but current research into the effectiveness of such approaches is mixed. This study sought to gauge the effectiveness that integrating engineering design projects into the traditional physical science classroom has on students understanding of the applied scientific concepts as opposed to traditional instruction. The results indicate that integration of engineering design projects has a positive effect on student's science concept knowledge as well as their motivation in the classroom.
Hart, George W
This book deals with the mathematical properties of dimensioned quantities, such as length, mass, voltage, and viscosity. Beginning with a careful examination of how one expresses the numerical results of a measurement and uses these results in subsequent manipulations, the author rigorously constructs the notion of dimensioned numbers and discusses their algebraic structure. The result is a unification of linear algebra and traditional dimensional analysis that can be extended from the scalars to which the traditional analysis is perforce restricted to multidimensional vectors of the sort frequently encountered in engineering, systems theory, economics, and other applications.
Platzhoff, A. [Hochschule Wismar, Fachbereich Maschinenbau, Verfahrens- und Umwelttechnik (Germany); Reitz, J. [Initiativkreis Druckzellenmotor e.V., Heilbronn (Germany); Windisch, H. [Fachhochschule Heilbronn (Germany); Mueller, H.
Can the growing demand for inexpensive mobile or steady state traction units still be met in 50 years? Limited resources of crude oil and changes of the earth climate by an increasing greenhouse gas pollution are calling the established stroke piston engine more and more into question. Now an evolutionary method of resolution was made out of characteristics from the Otto-, the Diesel-, the Wankel engine and the gas turbine. The new ''Druckzellen-Motor DZM'' (Pressure Cell Engine) is a thermodynamical engine, working after the basic Otto-engine rules, but significantly enhancing efficiency by functionally separating the single working processes into dedicated function units. The compression ratio and the expansion ratio are independently variable from each other. The continous isochorous combustion in a thermal accumulator only requires a low quality in fuel conditioning. Starting the engine from zero r.p.m. can be achieved by the charged thermal accumulator at maximum torque similar to a steam engine or a DC motor. (orig.)
Balters, Stephanie; Steinert, Martin
This paper presents the theoretical and practical fundamentals of using physiology sensors to capture human emotion reactivity in a products or systems engineering context. We aim to underline the complexity of regulating (internal and external) effects on the human body and highly individual physiological (emotion) responses and provide a starting point for engineering researchers entering the field. Although great advances have been made in scenarios involving human-machine interactions, th...
McPhail, Stephen; Furlong, Maaten; Huvenne, Veerle; Stevenson, Peter
In September 2007 on RRS Discovery, the Autosub6000 Autonomous Underwater Vehicle (AUV) completed its first deep water engineering trials, and less than a year later, fitted with a multibeam bathymetric mapping sonar, carried out its first science missions, as part of a geology and geophysics science cruise onboard the RRS James Cook to investigate potential geo-hazards (such as tsunami generating landslides) on the European and North African margin. In the spirit of true AUV a...
The Division of Natural Sciences and Mathematics at Claflin College consists of the Departments of Biology, Chemistry, Computer Science, Physics, Engineering and Mathematics. It offers a variety of major and minor academic programs designed to meet the mission and objectives of the college. The division`s pursuit to achieve excellence in science education is adversely impacted by the poor academic preparation of entering students and the lack of equipment, facilities and research participation, required to impart adequate academic training and laboratory skills to the students. Funds were received from the US Department of Energy to improve the divisional facilities and laboratory equipment and establish mechanism at pre-college and college levels to increase (1) the pool of high school students who will enroll in Science and Mathematics courses (2) the pool of well qualified college freshmen who will seek careers in Science, Engineering and Mathematics (3) the graduation rate in Science,engineering and Mathematics at the undergraduate level and (4) the pool of well-qualified students who can successfully compete to enter the graduate schools of their choice in the fields of science, engineering, and mathematics. The strategies that were used to achieve the mentioned objectives include: (1) Improved Mentoring and Advisement, (2) Summer Science Camp for 7th and 8th graders, (3) Summer Research Internships for Claflin SEM Seniors, (4) Summer Internships for Rising High School Seniors, (5) Development of Mathematical Skills at Pre-college/Post-secondary Levels, (6) Expansion of Undergraduate Seminars, (7) Exposure of Undergraduates to Guest Speakers/Roll Models, (8) Visitations by Undergraduate Students to Graduate Schools, and (9) Expanded Academic Program in Environmental Chemistry.
Full Text Available Mohammad T Alrefai,1–3 Divya Murali,4 Arghya Paul,4 Khalid M Ridwan,1,2 John M Connell,1,2 Dominique Shum-Tim1,2 1Division of Cardiac Surgery, 2Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada; 3King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 4Department of Chemical and Petroleum Engineering, School of Engineering, University of Kansas, Lawrence, KS, USA Abstract: Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing with the irreversible damage caused by the occlusion or stenosis of the supplying vessels. The applications of these new technologies are not yet fully established as part of the management of cardiac diseases but will become so in the near future. The discussion presented here reviews some of the pioneering works at this new frontier. Key results of allogeneic and autologous stem cell trials are presented, including the use of embryonic, bone marrow-derived, adipose-derived, and resident cardiac stem cells. Keywords: stem cells, cardiomyocytes, cardiac surgery, heart failure, myocardial ischemia, heart, scaffolds, organoids, cell sheet and tissue engineering
Yasinzai, Masoom; Lev, Benjamin
Welcome to the proceedings of the Sixth International Conference on Management Science and Engineering Management (ICMSEM2012) held from November 11 to 14, 2012 at Quaid-i-Azam University, Islamabad, Pakistan and supported by Sichuan University (Chengdu, China), Quaid-i-Azam University (Islamabad, Pakistan) and The National Natural Science Foundation of China. The International Conference on Management Science and Engineering Management is the annual conference organized by the International Society of Management Science and Engineering Management. The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research results. The papers are classified into 8 sections: Computer and Networks, Information Technology, Decision Support System, Industrial Engineering, Supply Chain Management, Project Management, Manufacturing and Ecological Engineering. The key issues of the sixth ICMSEM cover variou...
Manzoli, Vita; Colter, David C; Dhanaraj, Sridevi; Fornoni, Alessia; Ricordi, Camillo; Pileggi, Antonello; Tomei, Alice A
Cellular transplantation may treat several human diseases by replacing damaged cells and/or providing a local source of trophic factors promoting regeneration. We utilized human renal epithelial cells (hRECs) isolated from cadaveric donors as a cell model. For efficacious implementation of hRECs for treatment of kidney diseases, we evaluated a novel encapsulation strategy for immunoisolation of hRECs and lentiviral transduction of the Green Fluorescent Protein (GFP) as model gene for genetic engineering of hRECs to secrete desired trophic factors. In specific, we determined whether encapsulation through conformal coating and/or GFP transduction of hRECs allowed preservation of cell viability and of their trophic factor secretion. To that end, we optimized cultures of hRECs and showed that aggregation in three-dimensional spheroids significantly preserved cell viability, proliferation, and trophic factor secretion. We also showed that both wild type and GFP-engineered hRECs could be efficiently encapsulated within conformal hydrogel coatings through our fluid dynamic platform and that this resulted in further improvement of cell viability and trophic factors secretion. Our findings may lay the groundwork for future therapeutics based on transplantation of genetically engineered human primary cells for treatment of diseases affecting kidneys and potentially other tissues. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Liu, Feng; Lee, Dong-Hoon; Lagoa, Ricardo; Kumar, Sandeep
The International Conference on Biomedical Engineering and Biotechnology (ICBEB) is an international meeting held once a year. This, the fourth International Conference on Biomedical Engineering and Biotechnology (ICBEB2015), will be held in Shanghai, China, during August 18th-21st, 2015. This annual conference intends to provide an opportunity for researchers and practitioners at home and abroad to present the most recent frontiers and future challenges in the fields of biomedical science, biomedical engineering, biomaterials, bioinformatics and computational biology, biomedical imaging and signal processing, biomechanical engineering and biotechnology, etc. The papers published in this issue are selected from this Conference, which witness the advances in biomedical engineering and biotechnology during 2014-2015.
Full Text Available This article describes the design of an interactive learning environment to increase student achievement in middle schools by addressing students' preconceptions, and promoting purposeful social collaboration, distributed cognition, and contextual learning. The paper presents the framework that guided our design efforts to immerse all students in a progression of guided-inquiry hands-on activities. Students find compelling reasons to learn by responding to authentic science-based challenges, both in simulations and hands-on activities, based on specific instructional objectives from the national standards.